Search of human proteins with 21618342

Search of human proteins with 21618342

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21618342 signal transducer and activator of transcription 5A
[Homo sapiens]
         (794 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21618342 signal transducer and activator of transcription 5A ...  1600   0.0  
gi|21618344 signal transducer and activator of transcription 5B ...  1465   0.0  
gi|23397678 signal transducer and activator of transcription 6 [...   453   e-127
gi|47458820 signal transducer and activator of transcription 3 i...   313   5e-85
gi|21618338 signal transducer and activator of transcription 3 i...   313   5e-85
gi|21618340 signal transducer and activator of transcription 3 i...   313   5e-85
gi|4507255 signal transducer and activator of transcription 4 [H...   291   2e-78
gi|6274552 signal transducer and activator of transcription 1 is...   286   7e-77
gi|21536301 signal transducer and activator of transcription 1 i...   286   7e-77
gi|4885615 signal transducer and activator of transcription 2 [H...   214   3e-55
gi|221139761 zinc finger protein 853 [Homo sapiens]                    56   1e-07
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    49   2e-05
gi|38044112 restin isoform b [Homo sapiens]                            44   4e-04
gi|4506751 restin isoform a [Homo sapiens]                             44   4e-04
gi|34878777 ring finger protein 20 [Homo sapiens]                      44   8e-04
gi|87298937 centrosomal protein 110kDa [Homo sapiens]                  42   0.002
gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo sap...    42   0.003
gi|17017963 forkhead box P2 isoform I [Homo sapiens]                   42   0.003
gi|22538413 forkhead box P2 isoform III [Homo sapiens]                 42   0.003
gi|149999352 forkhead box P2 isoform II [Homo sapiens]                 42   0.003
gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C...    42   0.003
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     42   0.003
gi|55770834 centromere protein F [Homo sapiens]                        42   0.003
gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo sapi...    42   0.003
gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo sapi...    42   0.003
gi|38348729 hypothetical protein LOC203238 [Homo sapiens]              42   0.003
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    41   0.004
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    41   0.004
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    41   0.004
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    41   0.004

>gi|21618342 signal transducer and activator of transcription 5A
           [Homo sapiens]
          Length = 794

 Score = 1600 bits (4143), Expect = 0.0
 Identities = 794/794 (100%), Positives = 794/794 (100%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL
Sbjct: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
           LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV
Sbjct: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120

Query: 121 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL 180
           REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
Sbjct: 121 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL 180

Query: 181 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL 240
           RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
Sbjct: 181 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL 240

Query: 241 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC 300
           RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
Sbjct: 241 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC 300

Query: 301 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL 360
           QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
Sbjct: 301 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL 360

Query: 361 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS 420
           NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS
Sbjct: 361 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS 420

Query: 421 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA 480
           LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA
Sbjct: 421 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA 480

Query: 481 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN 540
           TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
Sbjct: 481 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN 540

Query: 541 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK 600
           SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK
Sbjct: 541 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK 600

Query: 601 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL 660
           QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL
Sbjct: 601 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL 660

Query: 661 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY 720
           GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY
Sbjct: 661 GDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATY 720

Query: 721 MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS 780
           MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS
Sbjct: 721 MDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLS 780

Query: 781 PPAGLFTSARGSLS 794
           PPAGLFTSARGSLS
Sbjct: 781 PPAGLFTSARGSLS 794


>gi|21618344 signal transducer and activator of transcription 5B
           [Homo sapiens]
          Length = 787

 Score = 1465 bits (3792), Expect = 0.0
 Identities = 731/779 (93%), Positives = 747/779 (95%), Gaps = 5/779 (0%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           MA WIQAQQLQG+AL QMQ LYGQHFPIEVRHYL+QWIESQ WD++DLDNPQ+  +ATQL
Sbjct: 1   MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQL 60

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
           LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQ TYDRCP+ELVRCIRHILYNEQRLV
Sbjct: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120

Query: 121 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL 180
           REANN SSPAG L DAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL
Sbjct: 121 REANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL 180

Query: 181 RIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL 240
           RIQAQF  LAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL
Sbjct: 181 RIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLL 240

Query: 241 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC 300
           RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC
Sbjct: 241 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC 300

Query: 301 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL 360
           QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL
Sbjct: 301 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL 360

Query: 361 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS 420
           NVHMNPPQVKATIISEQQAKSLLKNENTRN+ SGEILNNCCVMEYHQATGTLSAHFRNMS
Sbjct: 361 NVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMS 420

Query: 421 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA 480
           LKRIKR+DRRGAESVTEEKFT+LFESQFSVG NELVFQVKTLSLPVVVIVHGSQD+NATA
Sbjct: 421 LKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATA 480

Query: 481 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN 540
           TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN
Sbjct: 481 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNN 540

Query: 541 SSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK 600
           SSSHLEDYSGLSVSWSQFNRENLPG NYTFWQWFDGVMEVLKKH KPHWNDGAILGFVNK
Sbjct: 541 SSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNK 600

Query: 601 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRL 660
           QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDS ER  WNL PFTTRDFSIRSLADRL
Sbjct: 601 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRL 660

Query: 661 GDLSYLIYVFPDRPKDEVFSKYYTPV-----LAKAVDGYVKPQIKQVVPEFVNASADAGG 715
           GDL+YLIYVFPDRPKDEV+SKYYTPV      AKAVDGYVKPQIKQVVPEFVNASADAGG
Sbjct: 661 GDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGG 720

Query: 716 SSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDS 774
            SATYMDQAPSPAVCPQA YNMYPQNPD VLD DG+FDL++TMDVAR VEELL RPMDS
Sbjct: 721 GSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDS 779


>gi|23397678 signal transducer and activator of transcription 6
           [Homo sapiens]
          Length = 847

 Score =  453 bits (1166), Expect = e-127
 Identities = 301/786 (38%), Positives = 436/786 (55%), Gaps = 86/786 (10%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           M+ W    ++  + ++++ V + QH    +RH L  W+ESQPW+ +   +      A+ L
Sbjct: 1   MSLWGLVSKMPPEKVQRLYVDFPQH----LRHLLGDWLESQPWEFLVGSDAFCCNLASAL 56

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
           L   VQ LQ     Q GE   +L+    H +T L+  Y R PL+LV   R IL  E++ V
Sbjct: 57  LSDTVQHLQASVGEQ-GEGSTILQ----HIST-LESIYQRDPLKLVATFRQILQGEKKAV 110

Query: 121 REANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESL 180
            E                         F  L +     + ELK            ++  L
Sbjct: 111 MEQ------------------------FRHLPMPFHWKQEELK------------FKTGL 134

Query: 181 R-IQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQL 239
           R +Q +  ++  L    R + +   +  QVSL + ++  A         LA   Q+T   
Sbjct: 135 RRLQHRVGEIHLL----REALQKGAEAGQVSLHSLIETPANGTGPSEA-LAMLLQETTGE 189

Query: 240 LRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHL 299
           L   + ++L    I WKR+QQLAGNG P E SL  LQ  CE L +I  Q +Q++  A   
Sbjct: 190 LEAAKALVLKRIQI-WKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAG-- 246

Query: 300 CQQLPIPGPVE-EMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGG 358
                  G +E +  A +   + +++  LVTS F++EKQPPQVLKTQTKF A VR L+G 
Sbjct: 247 -------GELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGL 299

Query: 359 K-LNVHMNPPQVKATIISEQQAKSLL--KNENTRNECSGEILNNCCVMEYHQATGTLSAH 415
           + L     PP V+A +++E+QA+ L   +      E +GEI+NN   +E        SA 
Sbjct: 300 RFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSAL 359

Query: 416 FRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQD 475
           F+N+ LK+IKR +R+G ESVTEEK  VLF + F++G  +L  Q++ LSLP+VVIVHG+QD
Sbjct: 360 FKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQD 419

Query: 476 HNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQ 535
           +NA AT+LWDNAF+E  RVPF V ++V W ++CE LN+KF AEV +NRGL  E+ +FLAQ
Sbjct: 420 NNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQ 479

Query: 536 KLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAIL 595
           K+FN++S  +E +   SVSWSQFN+E L G  +TFWQWFDGV+++ K+  + +W+D  I+
Sbjct: 480 KIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLII 539

Query: 596 GFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERN--LWNLKPFTTRDFSI 653
           GF++KQ    LL+N+PDGTFLLRFSDSEIGGITIA      + +  + N++PF+ +D SI
Sbjct: 540 GFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSI 599

Query: 654 RSLADRLGDLSYLIYVFPDRPKDEVFSKYYTP-VLAKAVDGYVKPQIKQVV--------P 704
           RSL DR+ DL+ L  ++P +PKDE F  +Y P  + K   GYV   IK  V        P
Sbjct: 600 RSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTP 659

Query: 705 EF----VNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDV 760
           E     +  S D G +  + M     P + PQ    +YP +   +    G    +E+++V
Sbjct: 660 ELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQ----VYPPHSHSIPPYQG-LSPEESVNV 714

Query: 761 ARHVEE 766
               +E
Sbjct: 715 LSAFQE 720


>gi|47458820 signal transducer and activator of transcription 3
           isoform 3 [Homo sapiens]
          Length = 722

 Score =  313 bits (801), Expect = 5e-85
 Identities = 226/720 (31%), Positives = 362/720 (50%), Gaps = 66/720 (9%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           MA W Q QQL    L Q+  LY   FP+E+R +LA WIESQ W           + AT +
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYA----ASKESHATLV 56

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
              L+ E+ ++    + E   L +  L      LQ  Y   P+E+ R +   L+ E RL+
Sbjct: 57  FHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLL 116

Query: 121 REANNCSSPAGIL----VDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQY 176
           + A   +   G         +++K   + Q  +++R   QD E ++K ++  Q+ F   Y
Sbjct: 117 QTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176

Query: 177 QESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKT 236
           + +L+ Q     L         + ++  +QK   LE  L      L Q R  +  +    
Sbjct: 177 K-TLKSQGDMQDLNG-------NNQSVTRQKMQQLEQMLT----ALDQMRRSIVSELAGL 224

Query: 237 LQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRA 296
           L  +   Q  + D+EL  WKRRQQ+A  GGPP   LD L++W   LAE   Q RQQI++ 
Sbjct: 225 LSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL 284

Query: 297 EHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTK 347
           E L Q++   G P+ +    +   I ++   L+ S F++E+QP        P V+KT  +
Sbjct: 285 EELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ 344

Query: 348 FAATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYH 406
           F   VRLLV   +LN  +   ++K  I  +    + L+     N        N  VM   
Sbjct: 345 FTTKVRLLVKFPELNYQL---KIKVCIDKDSGDVAALRGSRKFNILG----TNTKVMNME 397

Query: 407 QAT-GTLSAHFRNMSLKRIK-----RADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK 460
           ++  G+LSA F++++L+  +     RA+   +  VTEE   + FE++  V    L   ++
Sbjct: 398 ESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETE--VYHQGLKIDLE 455

Query: 461 TLSLPVVVIVHGSQDHNATATVLWDNAFAE-PGRVPFAVPDKV-LWPQLCEALNMKFKAE 518
           T SLPVVVI +  Q  NA A++LW N     P  V F     +  W Q+ E L+ +F + 
Sbjct: 456 THSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST 515

Query: 519 VQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVM 578
            +  RGL+ E L  LA+KL     +    YSG  ++W++F +EN+ G  ++FW W D ++
Sbjct: 516 TK--RGLSIEQLTTLAEKLLGPGVN----YSGCQITWAKFCKENMAGKGFSFWVWLDNII 569

Query: 579 EVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAW--KFDS 635
           +++KK+    WN+G I+GF++K++   +L  KP GTFLLRFS+ S+ GG+T  W  K  S
Sbjct: 570 DLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDIS 629

Query: 636 PERNLWNLKPFTTRDFSIRSLAD-----RLGD-----LSYLIYVFPDRPKDEVFSKYYTP 685
            +  + +++P+T +  +  S A+     ++ D     +S L+Y++PD PK+E F KY  P
Sbjct: 630 GKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRP 689


>gi|21618338 signal transducer and activator of transcription 3
           isoform 2 [Homo sapiens]
          Length = 769

 Score =  313 bits (801), Expect = 5e-85
 Identities = 226/720 (31%), Positives = 362/720 (50%), Gaps = 66/720 (9%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           MA W Q QQL    L Q+  LY   FP+E+R +LA WIESQ W           + AT +
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYA----ASKESHATLV 56

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
              L+ E+ ++    + E   L +  L      LQ  Y   P+E+ R +   L+ E RL+
Sbjct: 57  FHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLL 116

Query: 121 REANNCSSPAGIL----VDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQY 176
           + A   +   G         +++K   + Q  +++R   QD E ++K ++  Q+ F   Y
Sbjct: 117 QTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176

Query: 177 QESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKT 236
           + +L+ Q     L         + ++  +QK   LE  L      L Q R  +  +    
Sbjct: 177 K-TLKSQGDMQDLNG-------NNQSVTRQKMQQLEQMLT----ALDQMRRSIVSELAGL 224

Query: 237 LQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRA 296
           L  +   Q  + D+EL  WKRRQQ+A  GGPP   LD L++W   LAE   Q RQQI++ 
Sbjct: 225 LSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL 284

Query: 297 EHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTK 347
           E L Q++   G P+ +    +   I ++   L+ S F++E+QP        P V+KT  +
Sbjct: 285 EELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ 344

Query: 348 FAATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYH 406
           F   VRLLV   +LN  +   ++K  I  +    + L+     N        N  VM   
Sbjct: 345 FTTKVRLLVKFPELNYQL---KIKVCIDKDSGDVAALRGSRKFNILG----TNTKVMNME 397

Query: 407 QAT-GTLSAHFRNMSLKRIK-----RADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK 460
           ++  G+LSA F++++L+  +     RA+   +  VTEE   + FE++  V    L   ++
Sbjct: 398 ESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETE--VYHQGLKIDLE 455

Query: 461 TLSLPVVVIVHGSQDHNATATVLWDNAFAE-PGRVPFAVPDKV-LWPQLCEALNMKFKAE 518
           T SLPVVVI +  Q  NA A++LW N     P  V F     +  W Q+ E L+ +F + 
Sbjct: 456 THSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST 515

Query: 519 VQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVM 578
            +  RGL+ E L  LA+KL     +    YSG  ++W++F +EN+ G  ++FW W D ++
Sbjct: 516 TK--RGLSIEQLTTLAEKLLGPGVN----YSGCQITWAKFCKENMAGKGFSFWVWLDNII 569

Query: 579 EVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAW--KFDS 635
           +++KK+    WN+G I+GF++K++   +L  KP GTFLLRFS+ S+ GG+T  W  K  S
Sbjct: 570 DLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDIS 629

Query: 636 PERNLWNLKPFTTRDFSIRSLAD-----RLGD-----LSYLIYVFPDRPKDEVFSKYYTP 685
            +  + +++P+T +  +  S A+     ++ D     +S L+Y++PD PK+E F KY  P
Sbjct: 630 GKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRP 689


>gi|21618340 signal transducer and activator of transcription 3
           isoform 1 [Homo sapiens]
          Length = 770

 Score =  313 bits (801), Expect = 5e-85
 Identities = 226/720 (31%), Positives = 362/720 (50%), Gaps = 66/720 (9%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           MA W Q QQL    L Q+  LY   FP+E+R +LA WIESQ W           + AT +
Sbjct: 1   MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYA----ASKESHATLV 56

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
              L+ E+ ++    + E   L +  L      LQ  Y   P+E+ R +   L+ E RL+
Sbjct: 57  FHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLL 116

Query: 121 REANNCSSPAGIL----VDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQY 176
           + A   +   G         +++K   + Q  +++R   QD E ++K ++  Q+ F   Y
Sbjct: 117 QTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNY 176

Query: 177 QESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKT 236
           + +L+ Q     L         + ++  +QK   LE  L      L Q R  +  +    
Sbjct: 177 K-TLKSQGDMQDLNG-------NNQSVTRQKMQQLEQMLT----ALDQMRRSIVSELAGL 224

Query: 237 LQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRA 296
           L  +   Q  + D+EL  WKRRQQ+A  GGPP   LD L++W   LAE   Q RQQI++ 
Sbjct: 225 LSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKL 284

Query: 297 EHLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTK 347
           E L Q++   G P+ +    +   I ++   L+ S F++E+QP        P V+KT  +
Sbjct: 285 EELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQ 344

Query: 348 FAATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYH 406
           F   VRLLV   +LN  +   ++K  I  +    + L+     N        N  VM   
Sbjct: 345 FTTKVRLLVKFPELNYQL---KIKVCIDKDSGDVAALRGSRKFNILG----TNTKVMNME 397

Query: 407 QAT-GTLSAHFRNMSLKRIK-----RADRRGAESVTEEKFTVLFESQFSVGSNELVFQVK 460
           ++  G+LSA F++++L+  +     RA+   +  VTEE   + FE++  V    L   ++
Sbjct: 398 ESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETE--VYHQGLKIDLE 455

Query: 461 TLSLPVVVIVHGSQDHNATATVLWDNAFAE-PGRVPFAVPDKV-LWPQLCEALNMKFKAE 518
           T SLPVVVI +  Q  NA A++LW N     P  V F     +  W Q+ E L+ +F + 
Sbjct: 456 THSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSST 515

Query: 519 VQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVM 578
            +  RGL+ E L  LA+KL     +    YSG  ++W++F +EN+ G  ++FW W D ++
Sbjct: 516 TK--RGLSIEQLTTLAEKLLGPGVN----YSGCQITWAKFCKENMAGKGFSFWVWLDNII 569

Query: 579 EVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAW--KFDS 635
           +++KK+    WN+G I+GF++K++   +L  KP GTFLLRFS+ S+ GG+T  W  K  S
Sbjct: 570 DLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDIS 629

Query: 636 PERNLWNLKPFTTRDFSIRSLAD-----RLGD-----LSYLIYVFPDRPKDEVFSKYYTP 685
            +  + +++P+T +  +  S A+     ++ D     +S L+Y++PD PK+E F KY  P
Sbjct: 630 GKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRP 689


>gi|4507255 signal transducer and activator of transcription 4 [Homo
           sapiens]
          Length = 748

 Score =  291 bits (744), Expect = 2e-78
 Identities = 218/714 (30%), Positives = 350/714 (49%), Gaps = 68/714 (9%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           M+ W Q QQL+   L Q+   Y  +FP+E+RH LAQWIE+Q W+A       +   AT L
Sbjct: 1   MSQWNQVQQLEIKFLEQVDQFYDDNFPMEIRHLLAQWIENQDWEAAS----NNETMATIL 56

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
           L+ L+ +L ++      E   LL   L      LQ  +   P+ +   I + L  E+R++
Sbjct: 57  LQNLLIQLDEQLGRVSKEKNLLLIHNLKRIRKVLQGKFHGNPMHVAVVISNCLREERRIL 116

Query: 121 REANN-CSSPA--GILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQ 177
             AN     P    +   ++S++   +      ++   Q TE + K L+  Q+ F  +Y+
Sbjct: 117 AAANMPVQGPLEKSLQSSSVSERQRNVEHKVAAIKNSVQMTEQDTKYLEDLQDEFDYRYK 176

Query: 178 ESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTL 237
                         +   ++  + +A+  ++V     LQ    +L   R E   K  + +
Sbjct: 177 T-------------IQTMDQSDKNSAMVNQEVLT---LQEMLNSLDFKRKEALSKMTQII 220

Query: 238 QLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAE 297
                    +L +EL  WKRRQQ+A  GGP    LD LQ+    LAE ++Q R+Q+ + E
Sbjct: 221 HETDLLMNTMLIEELQDWKRRQQIACIGGPLHNGLDQLQNCFTLLAESLFQLRRQLEKLE 280

Query: 298 HLCQQLPIPG-PVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKF 348
               ++   G P+      +   +T +I  L  ++F++E+QP        P VLKT  +F
Sbjct: 281 EQSTKMTYEGDPIPMQRTHMLERVTFLIYNLFKNSFVVERQPCMPTHPQRPLVLKTLIQF 340

Query: 349 AATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQA 408
              +RLL+  KL       +VKA+I      K++    N R    G  +    + E   +
Sbjct: 341 TVKLRLLI--KLPELNYQVKVKASI-----DKNVSTLSNRRFVLCGTNVKAMSIEE--SS 391

Query: 409 TGTLSAHFRNMSLKRIKRA----DRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSL 464
            G+LS  FR++  K +K +       G   VTEE  ++ FE+Q  +    L   ++T SL
Sbjct: 392 NGSLSVEFRHLQPKEMKSSAGGKGNEGCHMVTEELHSITFETQICLYG--LTIDLETSSL 449

Query: 465 PVVVIVHGSQDHNATATVLWDNAFAEPGR--VPFAVPDKVLWPQLCEALNMKFKAEVQSN 522
           PVV+I + SQ  NA A+++W N      +  V F  P      QL E ++ +F + V   
Sbjct: 450 PVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPPATLSQLLEVMSWQFSSYV--G 507

Query: 523 RGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLK 582
           RGL  + L  LA+KL   SS     YS   ++W++F +E+LPG ++TFW W + +++++K
Sbjct: 508 RGLNSDQLHMLAEKLTVQSS-----YSDGHLTWAKFCKEHLPGKSFTFWTWLEAILDLIK 562

Query: 583 KHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAW--KFDSPERNL 640
           KH  P W DG ++GFV+K++   LL +K  GTFLLRFS+S +GGIT  W    +S E   
Sbjct: 563 KHILPLWIDGYVMGFVSKEKERLLLKDKMPGTFLLRFSESHLGGITFTWVDHSESGEVRF 622

Query: 641 WNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRPKDEVFSKYYT 684
            +++P+     S    AD L D   ++          Y++PD PKD+ F K+Y+
Sbjct: 623 HSVEPYNKGRLSALPFADILRDYKVIMAENIPENPLKYLYPDIPKDKAFGKHYS 676


>gi|6274552 signal transducer and activator of transcription 1
           isoform alpha [Homo sapiens]
          Length = 750

 Score =  286 bits (731), Expect = 7e-77
 Identities = 221/721 (30%), Positives = 351/721 (48%), Gaps = 76/721 (10%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           M+ W + QQL    L Q+  LY   FP+E+R YLAQW+E Q W+        D + AT  
Sbjct: 1   MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHA----ANDVSFATIR 56

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
              L+ +L  +      E+ FLL+  +      LQ  +   P+++   I   L  E++++
Sbjct: 57  FHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKIL 116

Query: 121 REAN--NCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQE 178
             A   N +    I    M  K  +++     ++      E+E+K L+  Q+ +      
Sbjct: 117 ENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEY------ 170

Query: 179 SLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQ 238
                  F      + +   +      QKQ  L   L++    L   R E+  K  + L 
Sbjct: 171 ------DFKCKTLQNREHETNGVAKSDQKQEQL--LLKKMYLMLDNKRKEVVHKIIELLN 222

Query: 239 LLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEH 298
           +    Q  +++DEL++WKRRQQ A  GGPP   LD LQ+W   +AE + Q RQQ+++ E 
Sbjct: 223 VTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEE 282

Query: 299 LCQQLPIP-GPVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFA 349
           L Q+      P+ +    +      +   L+ S+F++E+QP        P VLKT  +F 
Sbjct: 283 LEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFT 342

Query: 350 ATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSG----EILN-NCCVM 403
             +RLLV   +LN ++     K  ++ +       K+ N RN   G     IL  +  VM
Sbjct: 343 VKLRLLVKLQELNYNL-----KVKVLFD-------KDVNERNTVKGFRKFNILGTHTKVM 390

Query: 404 EYHQAT-GTLSAHFRNMSLKRIKRADRRGAES---VTEEKFTVLFESQFSVGSNELVFQV 459
              ++T G+L+A FR++ LK  K A  R  E    VTEE  ++ FE+Q       LV  +
Sbjct: 391 NMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPG--LVIDL 448

Query: 460 KTLSLPVVVIVHGSQDHNATATVLWDNAF-AEPGRVPFAV-PDKVLWPQLCEALNMKFKA 517
           +T SLPVVVI + SQ  +  A++LW N   AEP  + F + P    W QL E L+ +F +
Sbjct: 449 ETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSS 508

Query: 518 EVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGV 577
             +  RGL  + L  L +KL   ++S      GL + W++F +EN+   N+ FW W + +
Sbjct: 509 VTK--RGLNVDQLNMLGEKLLGPNASP----DGL-IPWTRFCKENINDKNFPFWLWIESI 561

Query: 578 MEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAW---KF 633
           +E++KKH  P WNDG I+GF++K++   LL ++  GTFLLRFS+ S  G IT  W     
Sbjct: 562 LELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQ 621

Query: 634 DSPERNLWNLKPFTTRDFSIRSLADRLGDLSY----------LIYVFPDRPKDEVFSKYY 683
           +  E +   ++P+T ++ S  +  D + +             L Y++P+  KD  F KYY
Sbjct: 622 NGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYY 681

Query: 684 T 684
           +
Sbjct: 682 S 682


>gi|21536301 signal transducer and activator of transcription 1
           isoform beta [Homo sapiens]
          Length = 712

 Score =  286 bits (731), Expect = 7e-77
 Identities = 221/721 (30%), Positives = 351/721 (48%), Gaps = 76/721 (10%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQL 60
           M+ W + QQL    L Q+  LY   FP+E+R YLAQW+E Q W+        D + AT  
Sbjct: 1   MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHA----ANDVSFATIR 56

Query: 61  LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLV 120
              L+ +L  +      E+ FLL+  +      LQ  +   P+++   I   L  E++++
Sbjct: 57  FHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKIL 116

Query: 121 REAN--NCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQE 178
             A   N +    I    M  K  +++     ++      E+E+K L+  Q+ +      
Sbjct: 117 ENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEY------ 170

Query: 179 SLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQ 238
                  F      + +   +      QKQ  L   L++    L   R E+  K  + L 
Sbjct: 171 ------DFKCKTLQNREHETNGVAKSDQKQEQL--LLKKMYLMLDNKRKEVVHKIIELLN 222

Query: 239 LLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEH 298
           +    Q  +++DEL++WKRRQQ A  GGPP   LD LQ+W   +AE + Q RQQ+++ E 
Sbjct: 223 VTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEE 282

Query: 299 LCQQLPIP-GPVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQVLKTQTKFA 349
           L Q+      P+ +    +      +   L+ S+F++E+QP        P VLKT  +F 
Sbjct: 283 LEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFT 342

Query: 350 ATVRLLVG-GKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSG----EILN-NCCVM 403
             +RLLV   +LN ++     K  ++ +       K+ N RN   G     IL  +  VM
Sbjct: 343 VKLRLLVKLQELNYNL-----KVKVLFD-------KDVNERNTVKGFRKFNILGTHTKVM 390

Query: 404 EYHQAT-GTLSAHFRNMSLKRIKRADRRGAES---VTEEKFTVLFESQFSVGSNELVFQV 459
              ++T G+L+A FR++ LK  K A  R  E    VTEE  ++ FE+Q       LV  +
Sbjct: 391 NMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPG--LVIDL 448

Query: 460 KTLSLPVVVIVHGSQDHNATATVLWDNAF-AEPGRVPFAV-PDKVLWPQLCEALNMKFKA 517
           +T SLPVVVI + SQ  +  A++LW N   AEP  + F + P    W QL E L+ +F +
Sbjct: 449 ETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSS 508

Query: 518 EVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGV 577
             +  RGL  + L  L +KL   ++S      GL + W++F +EN+   N+ FW W + +
Sbjct: 509 VTK--RGLNVDQLNMLGEKLLGPNASP----DGL-IPWTRFCKENINDKNFPFWLWIESI 561

Query: 578 MEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSD-SEIGGITIAW---KF 633
           +E++KKH  P WNDG I+GF++K++   LL ++  GTFLLRFS+ S  G IT  W     
Sbjct: 562 LELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQ 621

Query: 634 DSPERNLWNLKPFTTRDFSIRSLADRLGDLSY----------LIYVFPDRPKDEVFSKYY 683
           +  E +   ++P+T ++ S  +  D + +             L Y++P+  KD  F KYY
Sbjct: 622 NGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYY 681

Query: 684 T 684
           +
Sbjct: 682 S 682


>gi|4885615 signal transducer and activator of transcription 2 [Homo
           sapiens]
          Length = 851

 Score =  214 bits (544), Expect = 3e-55
 Identities = 192/729 (26%), Positives = 326/729 (44%), Gaps = 97/729 (13%)

Query: 1   MAGWIQAQQLQGDALRQMQVLYGQHF-PIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQ 59
           MA W   Q L      Q+  LY     P+++R YLA WIE Q W    L +  D ++AT 
Sbjct: 1   MAQWEMLQNLDSPFQDQLHQLYSHSLLPVDIRQYLAVWIEDQNWQEAALGS--DDSKATM 58

Query: 60  LLEGLVQELQKKAEH-QVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQR 118
           L    + +L  +        +  LL+  L  +   +Q  + + P +L   I ++L  E+R
Sbjct: 59  LFFHFLDQLNYECGRCSQDPESLLLQHNLRKFCRDIQP-FSQDPTQLAEMIFNLLLEEKR 117

Query: 119 LVREANNCSSPAG--ILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQY 176
           ++ +A       G  +L   +  +  +I     +LR + +     + +L+  Q+ F  +Y
Sbjct: 118 ILIQAQRAQLEQGEPVLETPVESQQHEIESRILDLRAMMEKLVKSISQLKDQQDVFCFRY 177

Query: 177 QESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKT 236
               +IQA+                     K  SL+    +E + LQ+   EL ++ ++ 
Sbjct: 178 ----KIQAK--------------------GKTPSLDPHQTKEQKILQETLNELDKRRKEV 213

Query: 237 LQ----LLRKQQTII--LDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNR 290
           L     LL +  T+I  L  +L +WK +QQ A    P +  L+ L++W    A++++  R
Sbjct: 214 LDASKALLGRLTTLIELLLPKLEEWKAQQQKACIRAPIDHGLEQLETWFTAGAKLLFHLR 273

Query: 291 QQIRRAEHL-CQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQP--------PQV 341
           Q ++  + L C       P+ + +   NA +T+++  L+   F++E QP        P +
Sbjct: 274 QLLKELKGLSCLVSYQDDPLTKGVDLRNAQVTELLQRLLHRAFVVETQPCMPQTPHRPLI 333

Query: 342 LKTQTKFAATVRLLVG---------GKLNVHMNPPQVKATIISEQQAKSLLKNENT---- 388
           LKT +KF    RLLV           ++++  NPPQ++      ++   L  N+ T    
Sbjct: 334 LKTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPPQLQGF----RKFNILTSNQKTLTPE 389

Query: 389 RNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQF 448
           + +  G I +   +    Q +G               +   +G   VTEE   + F  ++
Sbjct: 390 KGQSQGLIWDFGYLTLVEQRSGGSG------------KGSNKGPLGVTEELHIISFTVKY 437

Query: 449 SVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAE--PGRVPFAVPDKVLWPQ 506
           +     L  ++KT +LPVV+I + +Q   A A+VLW N  +     +  F+ P K  W  
Sbjct: 438 TYQG--LKQELKTDTLPVVIISNMNQLSIAWASVLWFNLLSPNLQNQQFFSNPPKAPWSL 495

Query: 507 LCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGW 566
           L  AL+ +F + V   RGL  + L  L  KLF  +    +      +SW+ F +   P  
Sbjct: 496 LGPALSWQFSSYV--GRGLNSDQLSMLRNKLFGQNCRTEDPL----LSWADFTKRESPPG 549

Query: 567 NYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGG 626
              FW W D ++E++  H K  WNDG I+GFV++ Q   LL     GTFLLRFS+S  GG
Sbjct: 550 KLPFWTWLDKILELVHDHLKDLWNDGRIMGFVSRSQERRLLKKTMSGTFLLRFSESSEGG 609

Query: 627 ITIAW--KFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLI----------YVFPDRP 674
           IT +W    D  +  +++++P+T        L + +     L           +++P  P
Sbjct: 610 ITCSWVEHQDDDKVLIYSVQPYTKEVLQSLPLTEIIRHYQLLTEENIPENPLRFLYPRIP 669

Query: 675 KDEVFSKYY 683
           +DE F  YY
Sbjct: 670 RDEAFGCYY 678


>gi|221139761 zinc finger protein 853 [Homo sapiens]
          Length = 659

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 48/174 (27%), Positives = 84/174 (48%), Gaps = 18/174 (10%)

Query: 139 QKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERL 198
           Q+ LQ  Q  E+ RL  Q    E  + QQ QE  ++Q QE L+ Q Q  QL Q   ++  
Sbjct: 156 QQQLQPQQVQEQQRLQQQQ---EQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQ 212

Query: 199 SRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRR 258
            ++   QQ+Q+  + + Q++ Q  QQ ++ L ++  +  Q L +QQ   L  +L++ ++ 
Sbjct: 213 QQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQA 272

Query: 259 QQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQI--RRAEHLCQQLPIPGPVE 310
           Q                Q   ++  ++  Q +QQ+  ++ E L QQ   P P+E
Sbjct: 273 QLQQ-------------QLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLE 313



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 36/123 (29%), Positives = 64/123 (52%), Gaps = 12/123 (9%)

Query: 139 QKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFA-QLAQLSPQER 197
           Q HL++ Q  +      QD + +L +LQQ +   +  + + L+ + Q   Q  QL PQ+ 
Sbjct: 113 QPHLELQQQPQ------QDGQQQLSQLQQEKHQSV--HHQELKPELQLMHQQQQLQPQQ- 163

Query: 198 LSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKR 257
           +  +  LQQ+Q  L+    +E Q LQQ   E  ++  +  QLL++QQ  +   +L+Q + 
Sbjct: 164 VQEQQRLQQQQEQLQTQQAQEQQVLQQQ--EQLQQQVQEQQLLQQQQEQLQQQQLLQQQE 221

Query: 258 RQQ 260
           + Q
Sbjct: 222 QLQ 224



 Score = 37.4 bits (85), Expect = 0.055
 Identities = 68/279 (24%), Positives = 113/279 (40%), Gaps = 46/279 (16%)

Query: 6   QAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLV 65
           Q +QLQ    ++ QVL  Q         L Q ++ Q      L   Q++ Q  QLL+   
Sbjct: 173 QQEQLQTQQAQEQQVLQQQE-------QLQQQVQEQQL----LQQQQEQLQQQQLLQQQE 221

Query: 66  Q----ELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVR 121
           Q    + Q++ E    +   LL  + G    QL +       + +   +     +Q L++
Sbjct: 222 QLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQ 281

Query: 122 EANNCSSPAGILVDAMSQKHLQINQTFE-----------ELRLVTQDTENELKKLQQTQE 170
           +           +    Q+ LQ  Q              EL L+  D  +E +  QQ QE
Sbjct: 282 QQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQE 341

Query: 171 YFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELA 230
              ++ Q+ L  Q +  QL QL  QE L +          LE  L+++ Q L+Q  V+L 
Sbjct: 342 ---LERQQELERQQEQRQL-QLKLQEELQQ----------LEQQLEQQQQQLEQQEVQL- 386

Query: 231 EKHQKTLQLLRKQQTIILDDELIQWKRRQQL---AGNGG 266
                 ++L  +QQ + L+   +Q + + +L   AG GG
Sbjct: 387 --ELTPVELGAQQQEVQLELTPVQPELQLELVPAAGGGG 423



 Score = 31.6 bits (70), Expect = 3.0
 Identities = 34/128 (26%), Positives = 55/128 (42%), Gaps = 16/128 (12%)

Query: 183 QAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKT------ 236
           + Q  QL Q    ++  +   LQQ Q  LE   Q +    QQ      EKHQ        
Sbjct: 88  ELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELK 147

Query: 237 --LQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIR 294
             LQL+ +QQ   L  + +Q ++R Q        +  L   Q+  +++ +   Q +QQ++
Sbjct: 148 PELQLMHQQQQ--LQPQQVQEQQRLQ------QQQEQLQTQQAQEQQVLQQQEQLQQQVQ 199

Query: 295 RAEHLCQQ 302
             + L QQ
Sbjct: 200 EQQLLQQQ 207


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 93/442 (21%), Positives = 177/442 (40%), Gaps = 53/442 (11%)

Query: 52   QDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRH 111
            +D     Q     +  LQ + +H   E     K + G   +  Q +     ++ ++    
Sbjct: 2825 EDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMS 2884

Query: 112  ILYNEQ-RLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQE 170
             L N++ RL++E  N           + Q++LQINQ   EL  +    + +L++ Q   +
Sbjct: 2885 SLQNDRDRLLKELKN-----------LQQQYLQINQEITELHPL----KAQLQEYQDKTK 2929

Query: 171  YFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELA 230
             F I  QE LR             QE LS +  L Q ++   +W   E +  +QY + ++
Sbjct: 2930 AFQIM-QEELR-------------QENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAIS 2975

Query: 231  EKHQK---TLQLLRKQQTIILDDELIQWK-RRQQLAGNGGPPEGSLDVLQSWCEKLAEII 286
            +K Q+      L+R+ ++     + ++ + +RQ        P+GS +++    E L   +
Sbjct: 2976 DKDQQLSHLQNLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYE-TELLRTQL 3034

Query: 287  WQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQP--PQVLKT 344
              + ++I + E   QQL       ++L E N   T  I    TS  + E Q     +L  
Sbjct: 3035 NDSLKEIHQKELRIQQL--NSNFSQLLEEKN---TLSIQLCDTSQSLRENQQHYGDLLNH 3089

Query: 345  QTKFAATVRLLVGGKLNVHMNP--PQVKATIISEQQAKSLLKNENTRNECSGEILNNCCV 402
                   V+ L  G LN+ + P  PQ K  +  +   + L + + + +E   ++ N    
Sbjct: 3090 CAVLEKQVQELQAGPLNIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNT--- 3146

Query: 403  MEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTL 462
                Q    L    + +  +R +R     A SV EE+   L  S++      ++    T 
Sbjct: 3147 ---RQEVNELR---KLLEEERDQRVAAENALSVAEEQIRRLEHSEWDSSRTPIIGSCGTQ 3200

Query: 463  SLPVVVIVHGSQDHNATATVLW 484
               +++ +  +      + V W
Sbjct: 3201 EQALLIDLTSNSCRRTRSGVGW 3222



 Score = 30.0 bits (66), Expect = 8.8
 Identities = 26/95 (27%), Positives = 47/95 (49%), Gaps = 2/95 (2%)

Query: 135 DAMSQKHLQINQTFEELRLVTQ-DTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLS 193
           DA  +  +++++  E L+LVTQ D E E+++  +  +  + +++ESL  +AQ   L Q  
Sbjct: 223 DARFETQVRLHED-ELLQLVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQE 281

Query: 194 PQERLSRETALQQKQVSLEAWLQREAQTLQQYRVE 228
                 R   L Q+   +EA       T++  R E
Sbjct: 282 LTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREE 316



 Score = 30.0 bits (66), Expect = 8.8
 Identities = 22/121 (18%), Positives = 61/121 (50%), Gaps = 4/121 (3%)

Query: 115  NEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFII 174
            ++++LV+E  +  S          +KH ++ + +E L    ++  NE +++Q   E  + 
Sbjct: 1582 DKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVE-AVR 1640

Query: 175  QYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQ 234
            Q ++ L  + +  +  +   +++L      +Q+   ++  +++ A++ QQ  +EL E++ 
Sbjct: 1641 QEKQELYGKLRSTEANKKETEKQLQE---AEQEMEEMKEKMRKFAKSKQQKILELEEEND 1697

Query: 235  K 235
            +
Sbjct: 1698 R 1698


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 59/256 (23%), Positives = 104/256 (40%), Gaps = 23/256 (8%)

Query: 59   QLLEGLVQELQKKAEHQVGEDGFLLK------IKLGHYATQLQKTYDRCPLELVRCIRHI 112
            +L E  V+ELQ K         FL K      +K      +  K ++    EL R +  +
Sbjct: 906  RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 965

Query: 113  LYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYF 172
               E+++    N C         A S+   +  +  + L+    DTE++LK  ++ +   
Sbjct: 966  ---EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE-ENSG 1021

Query: 173  IIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSL---------EAWLQREAQTLQ 223
            ++Q  E LR QA  A+ AQ +       E   ++K  +L          A LQ E  TL+
Sbjct: 1022 LLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1081

Query: 224  QYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLA 283
            +  ++  E+  K+ +LL  +   + +      K  + L          L  LQ    KLA
Sbjct: 1082 ENNLKNVEELNKSKELLTVENQKMEEFR----KEIETLKQAAAQKSQQLSALQEENVKLA 1137

Query: 284  EIIWQNRQQIRRAEHL 299
            E + ++R ++   + L
Sbjct: 1138 EELGRSRDEVTSHQKL 1153



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 33/145 (22%), Positives = 63/145 (43%), Gaps = 14/145 (9%)

Query: 116  EQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQE--YFI 173
            E++L++      +    ++        Q+ +  +ELRL  +D E    KL +  E   F+
Sbjct: 870  EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL 929

Query: 174  IQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRV------ 227
             +  E + ++A+ +Q       E   +E  L++K   LE  ++      Q+ +       
Sbjct: 930  QKSIEDMTVKAEQSQQEAAKKHEEEKKE--LERKLSDLEKKMETSHNQCQELKARYERAT 987

Query: 228  -ELAEKHQKTLQLLRKQQTIILDDE 251
             E   KH++ LQ L+K    +LD E
Sbjct: 988  SETKTKHEEILQNLQK---TLLDTE 1009



 Score = 30.0 bits (66), Expect = 8.8
 Identities = 35/155 (22%), Positives = 69/155 (44%), Gaps = 12/155 (7%)

Query: 149 EELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQ 208
           + LR  + + ++E+KKL+Q  E    Q +       +  + A+ S    ++RE  LQ ++
Sbjct: 731 DALRKASSEGKSEMKKLRQQLEAAEKQIKH-----LEIEKNAESSKASSITRE--LQGRE 783

Query: 209 VSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPP 268
           + L   LQ     + Q +  L    +K LQ+L+++     ++ +   +  Q+        
Sbjct: 784 LKLTN-LQENLSEVSQVKETL----EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 838

Query: 269 EGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQL 303
           E   ++L S  EKL E +     + R  +   +QL
Sbjct: 839 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL 873


>gi|4506751 restin isoform a [Homo sapiens]
          Length = 1427

 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 59/256 (23%), Positives = 104/256 (40%), Gaps = 23/256 (8%)

Query: 59   QLLEGLVQELQKKAEHQVGEDGFLLK------IKLGHYATQLQKTYDRCPLELVRCIRHI 112
            +L E  V+ELQ K         FL K      +K      +  K ++    EL R +  +
Sbjct: 941  RLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLSDL 1000

Query: 113  LYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYF 172
               E+++    N C         A S+   +  +  + L+    DTE++LK  ++ +   
Sbjct: 1001 ---EKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDKLKGARE-ENSG 1056

Query: 173  IIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSL---------EAWLQREAQTLQ 223
            ++Q  E LR QA  A+ AQ +       E   ++K  +L          A LQ E  TL+
Sbjct: 1057 LLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1116

Query: 224  QYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLA 283
            +  ++  E+  K+ +LL  +   + +      K  + L          L  LQ    KLA
Sbjct: 1117 ENNLKNVEELNKSKELLTVENQKMEEFR----KEIETLKQAAAQKSQQLSALQEENVKLA 1172

Query: 284  EIIWQNRQQIRRAEHL 299
            E + ++R ++   + L
Sbjct: 1173 EELGRSRDEVTSHQKL 1188



 Score = 34.7 bits (78), Expect = 0.36
 Identities = 33/145 (22%), Positives = 63/145 (43%), Gaps = 14/145 (9%)

Query: 116  EQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQE--YFI 173
            E++L++      +    ++        Q+ +  +ELRL  +D E    KL +  E   F+
Sbjct: 905  EEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFL 964

Query: 174  IQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRV------ 227
             +  E + ++A+ +Q       E   +E  L++K   LE  ++      Q+ +       
Sbjct: 965  QKSIEDMTVKAEQSQQEAAKKHEEEKKE--LERKLSDLEKKMETSHNQCQELKARYERAT 1022

Query: 228  -ELAEKHQKTLQLLRKQQTIILDDE 251
             E   KH++ LQ L+K    +LD E
Sbjct: 1023 SETKTKHEEILQNLQK---TLLDTE 1044



 Score = 30.0 bits (66), Expect = 8.8
 Identities = 35/155 (22%), Positives = 69/155 (44%), Gaps = 12/155 (7%)

Query: 149 EELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQ 208
           + LR  + + ++E+KKL+Q  E    Q +       +  + A+ S    ++RE  LQ ++
Sbjct: 766 DALRKASSEGKSEMKKLRQQLEAAEKQIKH-----LEIEKNAESSKASSITRE--LQGRE 818

Query: 209 VSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPP 268
           + L   LQ     + Q +  L    +K LQ+L+++     ++ +   +  Q+        
Sbjct: 819 LKLTN-LQENLSEVSQVKETL----EKELQILKEKFAEASEEAVSVQRSMQETVNKLHQK 873

Query: 269 EGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQL 303
           E   ++L S  EKL E +     + R  +   +QL
Sbjct: 874 EEQFNMLSSDLEKLRENLADMEAKFREKDEREEQL 908


>gi|34878777 ring finger protein 20 [Homo sapiens]
          Length = 975

 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 41/146 (28%), Positives = 77/146 (52%), Gaps = 13/146 (8%)

Query: 127 SSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQF 186
           SS  G  +   ++K  ++N   EE + + Q+   EL+KL+Q  E    Q  E L+++ + 
Sbjct: 311 SSLYGGTITINARKFEEMNAELEENKELAQNRLCELEKLRQDFEEVTTQ-NEKLKVELRS 369

Query: 187 A--QLAQLSPQERL--SRETALQQKQVSLEAWLQREAQTL-------QQYRVELAEKHQK 235
           A  Q+ + +P+ R   S+ + L  + + L+A L  EA+TL        Q++VEL E+ + 
Sbjct: 370 AVEQVVKETPEYRCMQSQFSVLYNESLQLKAHLD-EARTLLHGTRGTHQHQVELIERDEV 428

Query: 236 TLQLLRKQQTIILDDELIQWKRRQQL 261
           +L    + + I L+D L Q ++  ++
Sbjct: 429 SLHKKLRTEVIQLEDTLAQVRKEYEM 454


>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
          Length = 2325

 Score = 42.0 bits (97), Expect = 0.002
 Identities = 56/290 (19%), Positives = 114/290 (39%), Gaps = 28/290 (9%)

Query: 109  IRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQT 168
            +R +     +L R+  +  +    +   + +K   +N   EEL  V        + L  T
Sbjct: 1831 VRKLQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHT 1890

Query: 169  QEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRV- 227
             ++  +   E  R+Q   ++ A      +   ET  QQ QV      + + + +QQ  + 
Sbjct: 1891 TKHQDVLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMF 1950

Query: 228  -------ELAEKHQKTLQLLRKQQTIILDDELIQWKRR-QQLAGNGGPPEGSLDVLQS-- 277
                   E  E   +T ++  K+Q   L+ EL   K +  Q+       E  +  LQ   
Sbjct: 1951 QRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEE 2010

Query: 278  -WCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEK 336
             WCE L + + Q ++Q+   E   Q +   G +  +  E ++   D   +L+ + F+ E+
Sbjct: 2011 RWCESLEKTLSQTKRQLSEREQ--QLVEKSGELLALQKEADSMRADF--SLLRNQFLTER 2066

Query: 337  QPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNE 386
            +  +      K A  ++              Q++  ++ ++Q  S ++ E
Sbjct: 2067 KKAEKQVASLKEALKIQ------------RSQLEKNLLEQKQENSCIQKE 2104



 Score = 33.9 bits (76), Expect = 0.61
 Identities = 35/142 (24%), Positives = 68/142 (47%), Gaps = 24/142 (16%)

Query: 135 DAMSQKHLQINQTFEELRLVTQDTENELKKL-----------------QQTQ-EYFIIQY 176
           + + Q+  ++ Q  ++L +V  D EN  K+L                 QQTQ +    + 
Sbjct: 647 ETLLQRLTEVEQERDQLEIVAMDAENMRKELAELESALQEQHEVNASLQQTQGDLSAYEA 706

Query: 177 QESLRIQAQFAQLAQLSPQ-ERLSRETALQQKQVSLEAWLQREAQTLQQYRVEL---AEK 232
           +   R+  + A+  QL  + E+++R T L+Q   +L+A L++E Q L+    +     EK
Sbjct: 707 ELEARLNLRDAEANQLKEELEKVTRLTQLEQS--ALQAELEKERQALKNALGKAQFSEEK 764

Query: 233 HQKTLQLLRKQQTIILDDELIQ 254
            Q+  +L  K + +  D+ L++
Sbjct: 765 EQENSELHAKLKHLQDDNNLLK 786



 Score = 30.0 bits (66), Expect = 8.8
 Identities = 43/219 (19%), Positives = 91/219 (41%), Gaps = 26/219 (11%)

Query: 50   NPQDRAQATQLLEGLVQELQKKAEHQVGEDGFL---LKIKLGHYATQLQKTYDRCPLELV 106
            N  D  Q  + LE  V+EL +  + +  +  F+   ++  +     +    +    ++ +
Sbjct: 1362 NIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEI 1421

Query: 107  RCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKL- 165
             CI   L   +  +REA+   + A   +    +K     + F + +     TE++ ++L 
Sbjct: 1422 ECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELE 1481

Query: 166  ---QQTQEYFIIQYQESLRIQAQFAQLAQLS-PQERLSRE------------TALQQKQV 209
               Q+T    +   Q+   +QA    L Q    QE + +E              L +K+ 
Sbjct: 1482 RRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKE 1541

Query: 210  SLEAWLQREAQTLQQYRVELAEKHQ-KTLQLLRKQQTII 247
             L   LQ+      Q  +E+AE+++   LQ+L++ + ++
Sbjct: 1542 KLTEELQK-----LQKDIEMAERNEDHHLQVLKESEVLL 1575


>gi|223634475 golgi autoantigen, golgin subfamily a, 6D [Homo
           sapiens]
          Length = 693

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 53/219 (24%), Positives = 99/219 (45%), Gaps = 20/219 (9%)

Query: 55  AQATQLLEGLVQ---ELQKKAEHQVGEDGFLLKI--KLGHYATQLQKTYDRCPLELVRCI 109
           A  TQ+ E L Q   E  + A+H  GE     +   K+   A  L++       E  R I
Sbjct: 213 AHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKE-------EKKRDI 265

Query: 110 RHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELK-KLQQT 168
             I   E+ L    N  + P  +   A++    Q+    + LR   +  E +L+ +++  
Sbjct: 266 HRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENN 325

Query: 169 QEYFIIQYQESLRIQAQFAQLAQ-----LSPQERLSRETA-LQQKQVSLEAWLQREAQTL 222
           Q   ++  ++  R+Q Q   L +     +  QERL  +   L+++Q +L+   +R  +  
Sbjct: 326 QALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQE 385

Query: 223 QQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQL 261
           Q+ R +  E+ +K  + L+KQ+  + D E   WK+ ++L
Sbjct: 386 QRLRKQ-EERLRKEEERLQKQEKRLWDQEERLWKKEERL 423


>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
          Length = 715

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 4/115 (3%)

Query: 149 EELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQ 208
           ++L+ + Q  +  + + QQ QE++  Q QE L +Q    Q  Q   Q++  ++   QQ+Q
Sbjct: 116 QQLQALLQQQQAVMLQQQQLQEFYKKQ-QEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQ 174

Query: 209 VSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQ---QTIILDDELIQWKRRQQ 260
              +   Q++ Q  QQ       K Q+  Q  ++Q   Q ++   +L+Q ++ QQ
Sbjct: 175 QQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQ 229



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 24/96 (25%), Positives = 46/96 (47%)

Query: 165 LQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQ 224
           L   Q   ++Q Q+++ +Q Q  Q      QE+L  +   QQ+Q   +   Q++ Q  QQ
Sbjct: 113 LSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQ 172

Query: 225 YRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQ 260
            + +  ++ Q+  Q  ++Q       E  Q +++QQ
Sbjct: 173 QQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQ 208



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 34/138 (24%), Positives = 62/138 (44%), Gaps = 10/138 (7%)

Query: 166 QQTQEYFIIQYQESLRIQAQFAQL-AQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQ 224
           QQ Q+    Q     ++QA   Q  A +  Q++L      QQ+Q+ L+   Q++ Q  QQ
Sbjct: 102 QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQ 161

Query: 225 YRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAE 284
            + +  ++ Q+  Q  ++QQ         Q +++QQ   + G         Q   ++LA 
Sbjct: 162 QQQQQQQQQQQQQQQQQQQQ---------QQQQQQQQQQHPGKQAKEQQQQQQQQQQLAA 212

Query: 285 IIWQNRQQIRRAEHLCQQ 302
                +QQ+ + + L QQ
Sbjct: 213 QQLVFQQQLLQMQQLQQQ 230



 Score = 30.0 bits (66), Expect = 8.8
 Identities = 38/137 (27%), Positives = 67/137 (48%), Gaps = 19/137 (13%)

Query: 134 VDAMSQKHLQINQTFEELR-LVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQ- 191
           V  +   HLQ  Q  +  R L+ Q   + LK  + + +      Q  L++    A +   
Sbjct: 44  VSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDK------QRPLQVPVSVAMMTPQ 97

Query: 192 -LSPQERLSRETALQQKQVS---LEAWLQRE-AQTLQQYRVELAEKHQKT---LQLLRKQ 243
            ++PQ+    +  LQQ+ +S   L+A LQ++ A  LQQ +++   K Q+    LQLL++Q
Sbjct: 98  VITPQQM---QQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQ 154

Query: 244 QTIILDDELIQWKRRQQ 260
           Q      +  Q +++QQ
Sbjct: 155 QQQQQQQQQQQQQQQQQ 171


>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
          Length = 623

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 4/115 (3%)

Query: 149 EELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQ 208
           ++L+ + Q  +  + + QQ QE++  Q QE L +Q    Q  Q   Q++  ++   QQ+Q
Sbjct: 24  QQLQALLQQQQAVMLQQQQLQEFYKKQ-QEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQ 82

Query: 209 VSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQ---QTIILDDELIQWKRRQQ 260
              +   Q++ Q  QQ       K Q+  Q  ++Q   Q ++   +L+Q ++ QQ
Sbjct: 83  QQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQ 137



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 24/96 (25%), Positives = 46/96 (47%)

Query: 165 LQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQ 224
           L   Q   ++Q Q+++ +Q Q  Q      QE+L  +   QQ+Q   +   Q++ Q  QQ
Sbjct: 21  LSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQ 80

Query: 225 YRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQ 260
            + +  ++ Q+  Q  ++Q       E  Q +++QQ
Sbjct: 81  QQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQ 116



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 34/138 (24%), Positives = 62/138 (44%), Gaps = 10/138 (7%)

Query: 166 QQTQEYFIIQYQESLRIQAQFAQL-AQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQ 224
           QQ Q+    Q     ++QA   Q  A +  Q++L      QQ+Q+ L+   Q++ Q  QQ
Sbjct: 10  QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQ 69

Query: 225 YRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAE 284
            + +  ++ Q+  Q  ++QQ         Q +++QQ   + G         Q   ++LA 
Sbjct: 70  QQQQQQQQQQQQQQQQQQQQ---------QQQQQQQQQQHPGKQAKEQQQQQQQQQQLAA 120

Query: 285 IIWQNRQQIRRAEHLCQQ 302
                +QQ+ + + L QQ
Sbjct: 121 QQLVFQQQLLQMQQLQQQ 138


>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
          Length = 740

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/115 (26%), Positives = 57/115 (49%), Gaps = 4/115 (3%)

Query: 149 EELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQ 208
           ++L+ + Q  +  + + QQ QE++  Q QE L +Q    Q  Q   Q++  ++   QQ+Q
Sbjct: 141 QQLQALLQQQQAVMLQQQQLQEFYKKQ-QEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQ 199

Query: 209 VSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQ---QTIILDDELIQWKRRQQ 260
              +   Q++ Q  QQ       K Q+  Q  ++Q   Q ++   +L+Q ++ QQ
Sbjct: 200 QQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQ 254



 Score = 32.3 bits (72), Expect = 1.8
 Identities = 24/96 (25%), Positives = 46/96 (47%)

Query: 165 LQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQ 224
           L   Q   ++Q Q+++ +Q Q  Q      QE+L  +   QQ+Q   +   Q++ Q  QQ
Sbjct: 138 LSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQ 197

Query: 225 YRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQ 260
            + +  ++ Q+  Q  ++Q       E  Q +++QQ
Sbjct: 198 QQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQ 233



 Score = 32.0 bits (71), Expect = 2.3
 Identities = 34/138 (24%), Positives = 62/138 (44%), Gaps = 10/138 (7%)

Query: 166 QQTQEYFIIQYQESLRIQAQFAQL-AQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQ 224
           QQ Q+    Q     ++QA   Q  A +  Q++L      QQ+Q+ L+   Q++ Q  QQ
Sbjct: 127 QQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQ 186

Query: 225 YRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAE 284
            + +  ++ Q+  Q  ++QQ         Q +++QQ   + G         Q   ++LA 
Sbjct: 187 QQQQQQQQQQQQQQQQQQQQ---------QQQQQQQQQQHPGKQAKEQQQQQQQQQQLAA 237

Query: 285 IIWQNRQQIRRAEHLCQQ 302
                +QQ+ + + L QQ
Sbjct: 238 QQLVFQQQLLQMQQLQQQ 255


>gi|51472437 PREDICTED: golgi autoantigen, golgin subfamily a, 6C
           isoform 1 [Homo sapiens]
          Length = 693

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 53/219 (24%), Positives = 99/219 (45%), Gaps = 20/219 (9%)

Query: 55  AQATQLLEGLVQ---ELQKKAEHQVGEDGFLLKI--KLGHYATQLQKTYDRCPLELVRCI 109
           A  TQ+ E L Q   E  + A+H  GE     +   K+   A  L++       E  R I
Sbjct: 213 AHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKE-------EKKRDI 265

Query: 110 RHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELK-KLQQT 168
             I   E+ L    N  + P  +   A++    Q+    + LR   +  E +L+ +++  
Sbjct: 266 HRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENN 325

Query: 169 QEYFIIQYQESLRIQAQFAQLAQ-----LSPQERLSRETA-LQQKQVSLEAWLQREAQTL 222
           Q   ++  ++  R+Q Q   L +     +  QERL  +   L+++Q +L+   +R  +  
Sbjct: 326 QALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQE 385

Query: 223 QQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQL 261
           Q+ R +  E+ +K  + L+KQ+  + D E   WK+ ++L
Sbjct: 386 QRLRKQ-EERLRKEEERLQKQEKRLWDQEERLWKKEERL 423


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 48/191 (25%), Positives = 88/191 (46%), Gaps = 27/191 (14%)

Query: 149  EELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRE--TALQQ 206
            ++LR++ ++ + EL+ L++  +    + +E ++ + +  +L   S  ++L RE  T L Q
Sbjct: 1951 KDLRMLRKEHQQELEILKKEYDQ---EREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQ 2007

Query: 207  KQVSLEAWLQREAQTLQQYRVELAEKHQ-KTLQLLRKQQTIILDDELIQWKRRQQLAGNG 265
            K+  LE  ++      Q+   EL E HQ +T QLL+K      DD+L +  +R +   + 
Sbjct: 2008 KEQELEMTIKETINKAQEVEAELLESHQEETNQLLKK--IAEKDDDLKRTAKRYEEILDA 2065

Query: 266  GPPEGSLDV--LQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDI 323
               E +  V  LQ+  E+L +   Q  +Q                 EE     N TI ++
Sbjct: 2066 REEEMTAKVRDLQTQLEELQKKYQQKLEQ-----------------EENPGNDNVTIMEL 2108

Query: 324  ISALVTSTFII 334
             + L   T +I
Sbjct: 2109 QTQLAQKTTLI 2119



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 66/348 (18%), Positives = 138/348 (39%), Gaps = 59/348 (16%)

Query: 46  IDLDNPQDRAQATQLLEGLVQE----LQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRC 101
           I+  + ++R    Q L  + QE    ++K +E Q+ +   L + +L     +L K     
Sbjct: 444 IEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTR 503

Query: 102 PLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENE 161
             E         + EQ  V    + S    I  +   Q+ L + +   + + +  ++EN+
Sbjct: 504 ERE---------FQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554

Query: 162 LKKLQQTQEYF---IIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQRE 218
           L+ LQQ  E +   I++ + SL               E+  +E   Q K +++   L+ E
Sbjct: 555 LRDLQQEAETYRTRILELESSL---------------EKSLQENKNQSKDLAVH--LEAE 597

Query: 219 AQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSW 278
                +    + EKH+  L+ L+ QQ  +  ++L   K++ Q           ++ L+  
Sbjct: 598 KNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQT---------EMEKLREK 648

Query: 279 CEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQP 338
           CE+  E + ++++ I +A                + E+N    + +    T    +  + 
Sbjct: 649 CEQEKETLLKDKEIIFQAH---------------IEEMNEKTLEKLDVKQTELESLSSEL 693

Query: 339 PQVLKTQTKFAATVRLLVG--GKLNVHMNPPQVKATIISEQQAKSLLK 384
            +VLK + K    + +L     K+   +     +     +QQ  S++K
Sbjct: 694 SEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIK 741


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 63/228 (27%), Positives = 98/228 (42%), Gaps = 44/228 (19%)

Query: 124 NNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELK----KLQQTQ------EYFI 173
           +N SSP   L+D +  ++ ++     EL L  Q  E E+K    K Q+ Q      +  +
Sbjct: 272 DNSSSPH--LLDQLKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVEL 329

Query: 174 IQYQ--------ESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQY 225
           I+ +        E +R  AQ+ Q +        ++ TAL+QK   L   L  + Q  +  
Sbjct: 330 IEKEKVLNKCRDELVRTTAQYDQAS--------TKYTALEQKLKKLTEDLSCQRQNAESA 381

Query: 226 RVELAEK---HQKTLQ--LLRKQQTI-ILDDELIQWKRR-----QQLAGNGGPPEGSLDV 274
           R  L +K    +K  Q  L R+Q++   LD E IQ K R     QQ        +  LD 
Sbjct: 382 RCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDK 441

Query: 275 LQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIP-----GPVEEMLAEVN 317
           L S  ++L   + + +Q++ RAE   Q   I        +EEM  E N
Sbjct: 442 LTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENN 489



 Score = 39.7 bits (91), Expect = 0.011
 Identities = 50/233 (21%), Positives = 106/233 (45%), Gaps = 24/233 (10%)

Query: 34   LAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQ 93
            L Q +E+      DL+   D++    + + + +      E  +  +  L +I+    + +
Sbjct: 1856 LLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIE 1915

Query: 94   LQKTYDRCPLELVR----CIRHILYNEQRLV----REANNCSSPAGIL---VDAMSQKHL 142
             +  Y    LE+V+    C+     N+Q+++     E +  +S    L   +D MS+K  
Sbjct: 1916 HEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTT 1975

Query: 143  QINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQES-LRIQAQFAQLAQLSPQERLSRE 201
             ++Q  E+++  TQ+ E+      Q++    IQ  E+ ++ + +  Q       E L  +
Sbjct: 1976 ALDQLSEKMKEKTQELESH-----QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDK 2030

Query: 202  TALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQ 254
            T LQ+K  SLE    +++Q L   + EL     +  QL ++++ ++ + E +Q
Sbjct: 2031 THLQEKLQSLE----KDSQALSLTKCEL---ENQIAQLNKEKELLVKESESLQ 2076


>gi|94538359 golgi autoantigen, golgin subfamily a, 6B [Homo
           sapiens]
          Length = 693

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 53/219 (24%), Positives = 99/219 (45%), Gaps = 20/219 (9%)

Query: 55  AQATQLLEGLVQ---ELQKKAEHQVGEDGFLLKI--KLGHYATQLQKTYDRCPLELVRCI 109
           A  TQ+ E L Q   E  + A+H  GE     +   K+   A  L++       E  R I
Sbjct: 213 AHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKE-------EKKRDI 265

Query: 110 RHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELK-KLQQT 168
             I   E+ L    N  + P  +   A++    Q+    + LR   +  E +L+ +++  
Sbjct: 266 HRIQELERSLSELKNQMAKPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENN 325

Query: 169 QEYFIIQYQESLRIQAQFAQLAQ-----LSPQERLSRETA-LQQKQVSLEAWLQREAQTL 222
           Q   ++  ++  R+Q Q   L +     +  QERL  +   L+++Q +L+   +R  +  
Sbjct: 326 QALSLLSKEQKQRLQEQEEMLREQEVQRVREQERLCEQNERLREQQKTLQEQGERLRKQE 385

Query: 223 QQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQL 261
           Q+ R +  E+ +K  + L+KQ+  + D E   WK+ ++L
Sbjct: 386 QRLRKQ-EERLRKEEERLQKQEKRLWDQEERLWKKEERL 423


>gi|146133848 golgi autoantigen, golgin subfamily a, 6 [Homo
           sapiens]
          Length = 693

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 53/219 (24%), Positives = 99/219 (45%), Gaps = 20/219 (9%)

Query: 55  AQATQLLEGLVQ---ELQKKAEHQVGEDGFLLKI--KLGHYATQLQKTYDRCPLELVRCI 109
           A  TQ+ E L Q   E  + A+H  GE     +   K+   A  L++       E  R I
Sbjct: 213 AHVTQVTESLKQVQLERDEYAKHIKGERARWQERMWKMSVEARTLKE-------EKKRDI 265

Query: 110 RHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELK-KLQQT 168
             I   E+ L    N  + P  +   A++    Q+    + LR   +  E +L+ +++  
Sbjct: 266 HRIQELERSLSELKNQMAEPPSLAPPAVTSVVEQLQDEAKHLRQEVEGLEGKLQSQVENN 325

Query: 169 QEYFIIQYQESLRIQAQFAQLAQ-----LSPQERLSRETA-LQQKQVSLEAWLQREAQTL 222
           Q   ++  ++  R+Q Q   L +     +  QERL  +   L+++Q +L+   +R  +  
Sbjct: 326 QALSLLSKEQKQRLQEQEEMLREQEAQRVREQERLCEQNERLREQQKTLQEQGERLRKQE 385

Query: 223 QQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQL 261
           Q+ R +  E+ +K  + L+KQ+  + D E   WK+ ++L
Sbjct: 386 QRLRKQ-EERLRKEEERLQKQEKRLWDQEERLWKKEERL 423


>gi|38348729 hypothetical protein LOC203238 [Homo sapiens]
          Length = 1326

 Score = 41.6 bits (96), Expect = 0.003
 Identities = 35/134 (26%), Positives = 68/134 (50%), Gaps = 19/134 (14%)

Query: 134 VDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLS 193
           VDA+     + N+    L  + ++  + +++LQQTQE    +  E ++        AQ S
Sbjct: 607 VDALIADLNRANEKIRHLEYICKNKSDTMRELQQTQEDTFTKVAEQIK--------AQES 658

Query: 194 PQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRK-QQTIILDD-- 250
              R  +E  LQ  ++ LE  +Q+ AQ  Q    E+AEK+ + L  + K  + ++L++  
Sbjct: 659 CWHRQKKELELQYSELFLE--VQKRAQKFQ----EIAEKNMEKLNHIEKSHEQLVLENSH 712

Query: 251 --ELIQWKRRQQLA 262
             +L+   +R+Q++
Sbjct: 713 FKKLLSQTQREQMS 726


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 12/130 (9%)

Query: 140 KHLQINQTFEELRLVTQDTENELKK---LQQTQEYFIIQYQESLRIQAQFAQLAQLSPQE 196
           K  ++ Q   E  +  +  E E K+   L++ QE  + + QE  R + +  +LA+   +E
Sbjct: 727 KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEE 786

Query: 197 RLSR----ETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDEL 252
            L R    E AL++++   E   Q EA    + R    E+ +K  +LLRKQ     ++E 
Sbjct: 787 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ-----EEEA 841

Query: 253 IQWKRRQQLA 262
            +W R ++ A
Sbjct: 842 AKWAREEEEA 851


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 12/130 (9%)

Query: 140 KHLQINQTFEELRLVTQDTENELKK---LQQTQEYFIIQYQESLRIQAQFAQLAQLSPQE 196
           K  ++ Q   E  +  +  E E K+   L++ QE  + + QE  R + +  +LA+   +E
Sbjct: 754 KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEE 813

Query: 197 RLSR----ETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDEL 252
            L R    E AL++++   E   Q EA    + R    E+ +K  +LLRKQ     ++E 
Sbjct: 814 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ-----EEEA 868

Query: 253 IQWKRRQQLA 262
            +W R ++ A
Sbjct: 869 AKWAREEEEA 878


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 12/130 (9%)

Query: 140 KHLQINQTFEELRLVTQDTENELKK---LQQTQEYFIIQYQESLRIQAQFAQLAQLSPQE 196
           K  ++ Q   E  +  +  E E K+   L++ QE  + + QE  R + +  +LA+   +E
Sbjct: 733 KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEE 792

Query: 197 RLSR----ETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDEL 252
            L R    E AL++++   E   Q EA    + R    E+ +K  +LLRKQ     ++E 
Sbjct: 793 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ-----EEEA 847

Query: 253 IQWKRRQQLA 262
            +W R ++ A
Sbjct: 848 AKWAREEEEA 857


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/130 (27%), Positives = 63/130 (48%), Gaps = 12/130 (9%)

Query: 140 KHLQINQTFEELRLVTQDTENELKK---LQQTQEYFIIQYQESLRIQAQFAQLAQLSPQE 196
           K  ++ Q   E  +  +  E E K+   L++ QE  + + QE  R + +  +LA+   +E
Sbjct: 733 KAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEE 792

Query: 197 RLSR----ETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDEL 252
            L R    E AL++++   E   Q EA    + R    E+ +K  +LLRKQ     ++E 
Sbjct: 793 ALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQ-----EEEA 847

Query: 253 IQWKRRQQLA 262
            +W R ++ A
Sbjct: 848 AKWAREEEEA 857


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.133    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 29,847,049
Number of Sequences: 37866
Number of extensions: 1314403
Number of successful extensions: 5098
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 240
Number of HSP's that attempted gapping in prelim test: 4426
Number of HSP's gapped (non-prelim): 655
length of query: 794
length of database: 18,247,518
effective HSP length: 110
effective length of query: 684
effective length of database: 14,082,258
effective search space: 9632264472
effective search space used: 9632264472
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.