Guide to the Human Genome
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Search of human proteins with 215422366

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|215422366 death-domain associated protein isoform b [Homo
sapiens]
         (752 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|215422366 death-domain associated protein isoform b [Homo sap...  1492   0.0  
gi|4503257 death-domain associated protein isoform a [Homo sapiens]  1457   0.0  
gi|215422388 death-domain associated protein isoform a [Homo sap...  1457   0.0  
gi|60498973 myelin transcription factor 1-like [Homo sapiens]          79   2e-14
gi|17975763 myelin transcription factor 1 [Homo sapiens]               75   2e-13
gi|155030232 proline, glutamic acid and leucine rich protein 1 [...    73   8e-13
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]           68   4e-11
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]           67   8e-11
gi|4505999 protein phosphatase 1G [Homo sapiens]                       66   1e-10
gi|29826282 protein phosphatase 1G [Homo sapiens]                      66   1e-10
gi|21735569 claspin [Homo sapiens]                                     64   5e-10
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]              64   5e-10
gi|55956788 nucleolin [Homo sapiens]                                   63   9e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    63   1e-09
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                        62   1e-09
gi|218505694 potassium channel tetramerisation domain containing...    62   1e-09
gi|210032580 SET domain containing 1B [Homo sapiens]                   62   1e-09
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    62   2e-09
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    62   2e-09
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    62   2e-09
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    62   2e-09
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    62   2e-09
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    62   2e-09
gi|115529449 upstream binding transcription factor, RNA polymera...    62   3e-09
gi|115529451 upstream binding transcription factor, RNA polymera...    62   3e-09
gi|7657671 upstream binding transcription factor, RNA polymerase...    62   3e-09
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     61   3e-09
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     61   3e-09
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi...    61   4e-09
gi|21361639 DIPB protein [Homo sapiens]                                60   6e-09

>gi|215422366 death-domain associated protein isoform b [Homo
           sapiens]
          Length = 752

 Score = 1492 bits (3863), Expect = 0.0
 Identities = 752/752 (100%), Positives = 752/752 (100%)

Query: 1   MRGSENCGEGRLERRFLSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGAR 60
           MRGSENCGEGRLERRFLSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGAR
Sbjct: 1   MRGSENCGEGRLERRFLSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGAR 60

Query: 61  GSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNI 120
           GSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNI
Sbjct: 61  GSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNI 120

Query: 121 LSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDP 180
           LSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDP
Sbjct: 121 LSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDP 180

Query: 181 TNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARL 240
           TNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARL
Sbjct: 181 TNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARL 240

Query: 241 KRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGD 300
           KRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGD
Sbjct: 241 KRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGD 300

Query: 301 VLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 360
           VLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV
Sbjct: 301 VLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 360

Query: 361 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADT 420
           DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADT
Sbjct: 361 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADT 420

Query: 421 PEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLE 480
           PEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLE
Sbjct: 421 PEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLE 480

Query: 481 QMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIV 540
           QMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIV
Sbjct: 481 QMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIV 540

Query: 541 SPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISS 600
           SPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISS
Sbjct: 541 SPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISS 600

Query: 601 SRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSY 660
           SRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSY
Sbjct: 601 SRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSY 660

Query: 661 VERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQ 720
           VERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQ
Sbjct: 661 VERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQ 720

Query: 721 TPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD 752
           TPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD
Sbjct: 721 TPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD 752


>gi|4503257 death-domain associated protein isoform a [Homo sapiens]
          Length = 740

 Score = 1457 bits (3772), Expect = 0.0
 Identities = 735/735 (100%), Positives = 735/735 (100%)

Query: 18  SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK 77
           SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK
Sbjct: 6   SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK 65

Query: 78  LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV 137
           LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV
Sbjct: 66  LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV 125

Query: 138 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR 197
           YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR
Sbjct: 126 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR 185

Query: 198 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC 257
           RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC
Sbjct: 186 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC 245

Query: 258 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP 317
           SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP
Sbjct: 246 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP 305

Query: 318 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR 377
           RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR
Sbjct: 306 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR 365

Query: 378 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ 437
           SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ
Sbjct: 366 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ 425

Query: 438 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE 497
           GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE
Sbjct: 426 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE 485

Query: 498 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 557
           AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA
Sbjct: 486 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 545

Query: 558 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 617
           ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA
Sbjct: 546 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 605

Query: 618 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT 677
           GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT
Sbjct: 606 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT 665

Query: 678 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA 737
           LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA
Sbjct: 666 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA 725

Query: 738 TQCDPEEIIVLSDSD 752
           TQCDPEEIIVLSDSD
Sbjct: 726 TQCDPEEIIVLSDSD 740


>gi|215422388 death-domain associated protein isoform a [Homo
           sapiens]
          Length = 740

 Score = 1457 bits (3772), Expect = 0.0
 Identities = 735/735 (100%), Positives = 735/735 (100%)

Query: 18  SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK 77
           SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK
Sbjct: 6   SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK 65

Query: 78  LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV 137
           LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV
Sbjct: 66  LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV 125

Query: 138 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR 197
           YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR
Sbjct: 126 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR 185

Query: 198 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC 257
           RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC
Sbjct: 186 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC 245

Query: 258 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP 317
           SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP
Sbjct: 246 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP 305

Query: 318 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR 377
           RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR
Sbjct: 306 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR 365

Query: 378 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ 437
           SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ
Sbjct: 366 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ 425

Query: 438 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE 497
           GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE
Sbjct: 426 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE 485

Query: 498 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 557
           AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA
Sbjct: 486 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 545

Query: 558 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 617
           ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA
Sbjct: 546 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 605

Query: 618 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT 677
           GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT
Sbjct: 606 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT 665

Query: 678 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA 737
           LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA
Sbjct: 666 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA 725

Query: 738 TQCDPEEIIVLSDSD 752
           TQCDPEEIIVLSDSD
Sbjct: 726 TQCDPEEIIVLSDSD 740


>gi|60498973 myelin transcription factor 1-like [Homo sapiens]
          Length = 1184

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 76/295 (25%), Positives = 131/295 (44%), Gaps = 34/295 (11%)

Query: 388 ISKYAMLQDKSEEGERKKRR---ARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASR 444
           ++K    QDK  +    KR+    +   +S    D  + + D  E       +       
Sbjct: 57  LAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDE 116

Query: 445 AETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDG 504
              +DE+DEE D EEEEE EEE+E+  D E+ ED+E  +E +E++EEE+EEEE       
Sbjct: 117 PGDEDEEDEEGDREEEEEIEEEDED--DDEDGEDVEDEEEEEEEEEEEEEEEE------- 167

Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSS---IDAESNG 561
             +    +   N + ++  ++   ++ E  N   +V+ SLL+   +A  +      ES  
Sbjct: 168 --NEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEM 225

Query: 562 EQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVS 621
                 +LE++S  ++    + E L LD  S V  +   S K        +L  G G+V 
Sbjct: 226 NSNTSNSLEDDSDKNENLGRKSE-LSLDLDSDVVRETVDSLK--------LLAQGHGVVL 276

Query: 622 STSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKIC 676
           S + N      N+ DS    + SR         P+ N  +E+   + E++ +++C
Sbjct: 277 SENMN----DRNYADSMSQ-QDSRNMNYVMLGKPMNNGLMEK---MVEESDEEVC 323


>gi|17975763 myelin transcription factor 1 [Homo sapiens]
          Length = 1121

 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 44/108 (40%), Positives = 63/108 (58%), Gaps = 12/108 (11%)

Query: 398 SEEGER------KKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDED 451
           SEEGE+      +     ++ T+  S D    SL+          +G  S       +E+
Sbjct: 207 SEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILS------HEEE 260

Query: 452 DEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499
           DEE +EEEEEEEE+EEEE  + EEEE+ E+ +E +E++EEE+EEEEAA
Sbjct: 261 DEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAA 308



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 38/166 (22%), Positives = 72/166 (43%), Gaps = 12/166 (7%)

Query: 427 SGEGPSGMASQGCPSASRAETDDEDDEE---SDEEEEEEEEEEEEEATDSEEEEDLEQMQ 483
           S EG  G+  Q   +    E   E  ++      E+   EE  +++   S EEED E+ +
Sbjct: 207 SEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEED-EEEE 265

Query: 484 EGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGK-------QISRSSGEQQNK 536
           E +E++EE++EEEE    ++ ++      +   E+  E  +       Q   S    Q  
Sbjct: 266 EEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKA 325

Query: 537 GRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELE 582
             +  P   S +P     ++  S+ ++ E+ T   +S V+   E++
Sbjct: 326 PELRGPESPSPKPEYSVIVEVRSDDDKDED-THSRKSTVTDESEMQ 370



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 29/135 (21%), Positives = 55/135 (40%), Gaps = 19/135 (14%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           +S E    +  ++ +G  SH  +  E   +  E       +        E ++E++EE +
Sbjct: 238 QSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEE 297

Query: 457 EEEEEEEEE--------EEEEATDSEEEEDLEQMQEGQ-----------EDDEEEDEEEE 497
           EEEEEEEEE        E+   T +++  +L   +                D+++DE+  
Sbjct: 298 EEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTH 357

Query: 498 AAAGKDGDKSPMSSL 512
           +      D+S M  +
Sbjct: 358 SRKSTVTDESEMQDM 372



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 30/103 (29%), Positives = 43/103 (41%), Gaps = 10/103 (9%)

Query: 396 DKSEEGERKKRRARLQGTSSHSAD---TPEASLDSGEGPSGMASQGCPSASRAETDDEDD 452
           D S    RK+  A    +S  S+    +P+AS       +  +S   P +S+A   DE D
Sbjct: 670 DLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWD 729

Query: 453 EESD-------EEEEEEEEEEEEEATDSEEEEDLEQMQEGQED 488
              D        EEE EE E    +  S E +D E  +E  E+
Sbjct: 730 RPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEE 772


>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
            sapiens]
          Length = 1130

 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 69/240 (28%), Positives = 96/240 (40%), Gaps = 65/240 (27%)

Query: 431  PSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG----- 485
            P G    G P A   +    +   SDEEEEEEEEEEEEE  + EEEED E+ +E      
Sbjct: 862  PEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYF 921

Query: 486  ---------------------QEDDEEEDEEEE-----------AAAGKDGDKS------ 507
                                 +E++EEEDEEEE             AG + ++       
Sbjct: 922  EEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPT 981

Query: 508  -------PMSSLQISNEKNLEPGKQIS-RSSGEQQNKGRIVSPSLLSEEPLAPSSIDAES 559
                   P S  ++  E   EPG  +     G ++ +G   +P+L  E    PS  + E 
Sbjct: 982  LPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPE--ALPSQGEVER 1039

Query: 560  NGEQ------PEELTLEEESPVSQLFELEIE------ALPLDTPSSVETDISSSRKQSEE 607
             GE       P+EL  EE S    L E E E        P +TP+  E +  +  +  +E
Sbjct: 1040 EGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQE 1099



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 9/122 (7%)

Query: 393  MLQDKSEEGERKKRRARLQGTSSHSADTPEASLD-SGEGPS-GMASQGC----PSASRAE 446
            +L +  E G  ++R A    T +  A   +  ++  GE P+ G   Q      PSA    
Sbjct: 1005 LLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTL 1064

Query: 447  TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 506
             ++E ++ SD+ +   E   EEE    E E + E +QE ++DD      +      D +K
Sbjct: 1065 LEEETEDGSDKVQPPPETPAEEE---METETEAEALQEKEQDDTAAMLADFIDCPPDDEK 1121

Query: 507  SP 508
             P
Sbjct: 1122 PP 1123


>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
          Length = 709

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 51/177 (28%), Positives = 81/177 (45%), Gaps = 15/177 (8%)

Query: 402 ERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEE 461
           E  +R +R   +S    ++ E   D   G SG + +   +    E   E+D E DEE EE
Sbjct: 158 EVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEE 217

Query: 462 EEEEEEEEATDSEEEEDLEQMQEGQEDDEEE----DEEEEAAAGKDGDKSPMSSLQISNE 517
           + EE+EE   D EEEE+ E+ +E +E++EEE    DE ++   G D D    +S   S  
Sbjct: 218 DAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSES 277

Query: 518 KNLEPGKQISRSSGE-------QQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEEL 567
            +   G   S S  +       ++ + R +SP +         S  +ES  +Q  +L
Sbjct: 278 VSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRS----GSSASESYADQTSKL 330



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 45/207 (21%), Positives = 83/207 (40%), Gaps = 31/207 (14%)

Query: 397 KSEEGERKKRRARLQG------TSSHSADT----PEASLDSGEGPSGMASQGCPS----- 441
           K+EE +R +R  RL        +SS S +     PE +      P   A    P      
Sbjct: 96  KNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERI 155

Query: 442 -------ASRAETDDEDDEESDEEEEEEE------EEEEEEATDSEEE---EDLEQMQEG 485
                  ASR+    +++  S+E   + E       +E+   T++EEE   ED+E+ +E 
Sbjct: 156 GLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEV 215

Query: 486 QEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLL 545
           +ED EE++E +E    ++ ++      +   E+  E  ++  +  G   +     S S  
Sbjct: 216 EEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGS 275

Query: 546 SEEPLAPSSIDAESNGEQPEELTLEEE 572
                   S+ + S  +  +E   E +
Sbjct: 276 ESVSFTDGSVRSGSGTDGSDEKKKERK 302


>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
          Length = 727

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 46/152 (30%), Positives = 72/152 (47%), Gaps = 11/152 (7%)

Query: 402 ERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEE 461
           E  +R +R   +S    ++ E   D   G SG + +   +    E   E+D E DEE EE
Sbjct: 158 EVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEE 217

Query: 462 EEEEEEEEATDSEEEEDLEQMQEGQEDDEEE----DEEEEAAAGKDGDKSPMSSLQISNE 517
           + EE+EE   D EEEE+ E+ +E +E++EEE    DE ++   G D D    +S   S  
Sbjct: 218 DAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSES 277

Query: 518 KNLEPGKQISRSSGE-------QQNKGRIVSP 542
            +   G   S S  +       ++ + R +SP
Sbjct: 278 VSFTDGSVRSGSGTDGSDEKKKERKRARGISP 309



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 45/207 (21%), Positives = 83/207 (40%), Gaps = 31/207 (14%)

Query: 397 KSEEGERKKRRARLQG------TSSHSADT----PEASLDSGEGPSGMASQGCPS----- 441
           K+EE +R +R  RL        +SS S +     PE +      P   A    P      
Sbjct: 96  KNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERI 155

Query: 442 -------ASRAETDDEDDEESDEEEEEEE------EEEEEEATDSEEE---EDLEQMQEG 485
                  ASR+    +++  S+E   + E       +E+   T++EEE   ED+E+ +E 
Sbjct: 156 GLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEV 215

Query: 486 QEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLL 545
           +ED EE++E +E    ++ ++      +   E+  E  ++  +  G   +     S S  
Sbjct: 216 EEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGS 275

Query: 546 SEEPLAPSSIDAESNGEQPEELTLEEE 572
                   S+ + S  +  +E   E +
Sbjct: 276 ESVSFTDGSVRSGSGTDGSDEKKKERK 302


>gi|4505999 protein phosphatase 1G [Homo sapiens]
          Length = 546

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 49/130 (37%), Positives = 65/130 (50%), Gaps = 16/130 (12%)

Query: 412 GTSSHSADTPEASLDSGEG-PSGMASQGCPSASRA-----------ETDDEDDEESDEEE 459
           G SS+S    EA      G P+G A   C SAS             +++DE DE  +EEE
Sbjct: 213 GFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEE 272

Query: 460 EEEEEEEEEEATDSEE---EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516
           + EE  EEE+   SEE   EED +  +E +EDDE E+EEE    G +G + P S    + 
Sbjct: 273 DSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDE-EEEEEMMVPGMEGKEEPGSDSGTTA 331

Query: 517 EKNLEPGKQI 526
              L  GKQ+
Sbjct: 332 VVALIRGKQL 341



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 19/81 (23%), Positives = 39/81 (48%)

Query: 398 SEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDE 457
           S   ++  R A+ +       ++ EA  +  +       +   S+  AE ++++D+  + 
Sbjct: 242 SSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEA 301

Query: 458 EEEEEEEEEEEEATDSEEEED 478
           EE++EEEEEE      E +E+
Sbjct: 302 EEDDEEEEEEMMVPGMEGKEE 322



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 46/244 (18%), Positives = 88/244 (36%), Gaps = 7/244 (2%)

Query: 320 QLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSL 379
           +LQ   +DAF  +  +L     +  +       T+D       A  D V           
Sbjct: 89  KLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEE 148

Query: 380 AMSRLDEVISKYAMLQDK----SEEGERKKRRARLQGTSSHSA--DTPEASLDSGEGPSG 433
           A   ++E++++Y     K    S+ G         QG +  +   D+   +     GP+ 
Sbjct: 149 ATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTA 208

Query: 434 MASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEED 493
            A  G  S S   T+     E      E        +         +  ++ +++ +E +
Sbjct: 209 KAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAE 268

Query: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPS 553
           EEEE +     ++   SS +  NE++ E   + +    E++ +  +V      EEP + S
Sbjct: 269 EEEEDSEECSEEEDGYSSEEAENEED-EDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDS 327

Query: 554 SIDA 557
              A
Sbjct: 328 GTTA 331


>gi|29826282 protein phosphatase 1G [Homo sapiens]
          Length = 546

 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 49/130 (37%), Positives = 65/130 (50%), Gaps = 16/130 (12%)

Query: 412 GTSSHSADTPEASLDSGEG-PSGMASQGCPSASRA-----------ETDDEDDEESDEEE 459
           G SS+S    EA      G P+G A   C SAS             +++DE DE  +EEE
Sbjct: 213 GFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEE 272

Query: 460 EEEEEEEEEEATDSEE---EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516
           + EE  EEE+   SEE   EED +  +E +EDDE E+EEE    G +G + P S    + 
Sbjct: 273 DSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDE-EEEEEMMVPGMEGKEEPGSDSGTTA 331

Query: 517 EKNLEPGKQI 526
              L  GKQ+
Sbjct: 332 VVALIRGKQL 341



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 19/81 (23%), Positives = 39/81 (48%)

Query: 398 SEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDE 457
           S   ++  R A+ +       ++ EA  +  +       +   S+  AE ++++D+  + 
Sbjct: 242 SSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEA 301

Query: 458 EEEEEEEEEEEEATDSEEEED 478
           EE++EEEEEE      E +E+
Sbjct: 302 EEDDEEEEEEMMVPGMEGKEE 322



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 46/244 (18%), Positives = 88/244 (36%), Gaps = 7/244 (2%)

Query: 320 QLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSL 379
           +LQ   +DAF  +  +L     +  +       T+D       A  D V           
Sbjct: 89  KLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEE 148

Query: 380 AMSRLDEVISKYAMLQDK----SEEGERKKRRARLQGTSSHSA--DTPEASLDSGEGPSG 433
           A   ++E++++Y     K    S+ G         QG +  +   D+   +     GP+ 
Sbjct: 149 ATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTA 208

Query: 434 MASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEED 493
            A  G  S S   T+     E      E        +         +  ++ +++ +E +
Sbjct: 209 KAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAE 268

Query: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPS 553
           EEEE +     ++   SS +  NE++ E   + +    E++ +  +V      EEP + S
Sbjct: 269 EEEEDSEECSEEEDGYSSEEAENEED-EDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDS 327

Query: 554 SIDA 557
              A
Sbjct: 328 GTTA 331


>gi|21735569 claspin [Homo sapiens]
          Length = 1339

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 60/207 (28%), Positives = 96/207 (46%), Gaps = 28/207 (13%)

Query: 448 DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507
           D+ED  E +EEEEEE  +E EE  D EE+ + E+ +E  E++EE++EEEE    ++  + 
Sbjct: 623 DNEDGFEEEEEEEEEMTDESEE--DGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEF 680

Query: 508 PMSSLQISNEKNLEPGKQISRSSGE-QQNKGRIVSPSLLSEE----------------PL 550
            +SS +I  +   E  K+ +  S E  +  G +  P  LS +                P 
Sbjct: 681 LLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPT 740

Query: 551 APSSIDAESNGEQPEEL-------TLEEESPVSQLFELEIEALPLDTPSSVETDISSSRK 603
              S   E++G+QP +L        L +ES  +  FEL    +P   P + +T   +S  
Sbjct: 741 EEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFF 800

Query: 604 QSEEPFTTVLEN--GAGMVSSTSFNGG 628
            +   F +       A +VSS S + G
Sbjct: 801 PTAGGFRSPSPGLFRASLVSSASKSSG 827



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 9/120 (7%)

Query: 414  SSHSADTPEAS-LDSGEGPSGMAS---QGCPSASRAETDDEDDEESDEEEEEEEEEEEEE 469
            +S  A TP +S L+  E  S M     +     S +   D+++E+ +EE  +      + 
Sbjct: 949  TSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDN 1008

Query: 470  ATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRS 529
              DS+E+E  +   +   +D E+D+EEE        +S     Q+   K LE   ++S S
Sbjct: 1009 EFDSDEDEHSDSGNDLALEDHEDDDEEELL-----KRSEKLKRQMRLRKYLEDEAEVSGS 1063



 Score = 35.0 bits (79), Expect = 0.26
 Identities = 61/268 (22%), Positives = 99/268 (36%), Gaps = 39/268 (14%)

Query: 445  AETDDEDDEESDEEEEEEEEEEEEEATDS--EEEEDLE------QMQEGQEDDEEEDE-- 494
            AE    D    DE + EE +E EE+  D     +E+L+       M+   +DD+ +    
Sbjct: 1058 AEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLY 1117

Query: 495  EEEAAAGKDGDKSPMSSLQISNEKNLEPGKQIS---RSSGEQQNKGRIVSPSLLSEEPLA 551
            +E   A  D        ++    KN++   Q+    R S + Q + ++      SE    
Sbjct: 1118 QERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDE----SEARWR 1173

Query: 552  PSSIDAES---NGEQPEELTLEEESPVSQ-----LFELEIEALPLDTPSSVETDISSSRK 603
               I+ E    +  Q  ++T EEE  + +     +   ++ A  L   +S    I  S+ 
Sbjct: 1174 KERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKS 1233

Query: 604  QSEEPFTTVLENGAGMVSSTSF----------NGGVSPHNWGDSGPPCKKSRKEKKQTGS 653
                PF  +    A  V + S              +S HN   S P  + SR     T S
Sbjct: 1234 LLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHN--PSAP--RNSRNFVFHTLS 1289

Query: 654  GPLGNSYVERQRSVHEKNGKKICTLPSP 681
                 +  E  +S  +K G    T PSP
Sbjct: 1290 PVKAEAAKESSKSQVKKRGPSFMTSPSP 1317



 Score = 33.1 bits (74), Expect = 0.97
 Identities = 36/127 (28%), Positives = 57/127 (44%), Gaps = 16/127 (12%)

Query: 414 SSHSADTPEASLDSGEGPS---GMASQGCPS----ASRAETDDEDDEESDEEEEEEEEEE 466
           S   AD+P    DSG+G     G  S+G        S+   + +  ++SD E E+     
Sbjct: 20  SQEEADSPS---DSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASP 76

Query: 467 EEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM--SSLQISNEKNLEPGK 524
           E+   DS EEE+ E +  G+    +   +  A    D D+S M  S  Q + E  ++P  
Sbjct: 77  EKTTYDSAEEENKENLYAGKNTKIKRIYKTVA----DSDESYMEKSLYQENLEAQVKPCL 132

Query: 525 QISRSSG 531
           ++S  SG
Sbjct: 133 ELSLQSG 139



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 25/198 (12%)

Query: 429  EGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEE---EATDSEEEEDLEQM-QE 484
            +GP  M      +   A   D    +SD+++ EE+ +E E        E E+ L  M Q+
Sbjct: 1130 DGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQ 1189

Query: 485  GQEDDEEEDEEEE---------AAAGKDGDKSPMSSLQISNEKNL--EPGKQISRSSGEQ 533
            G+   EEE+E  E             K   K+    + I   K+L   P + I   S +Q
Sbjct: 1190 GKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQ 1249

Query: 534  QNKGRIVS---------PSLLSEEPLAP-SSIDAESNGEQPEELTLEEESPVSQLFELEI 583
               G +++          +L    P AP +S +   +   P +    +ES  SQ+ +   
Sbjct: 1250 VKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGP 1309

Query: 584  EALPLDTPSSVETDISSS 601
              +   +P  ++TD S+S
Sbjct: 1310 SFMTSPSPKHLKTDDSTS 1327


>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
          Length = 587

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 37/81 (45%), Positives = 46/81 (56%), Gaps = 11/81 (13%)

Query: 447 TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 506
           +DDED+EE +E EEEEEE EEEE  D EEEE           +EEE+EEEE      G+K
Sbjct: 358 SDDEDEEEEEEGEEEEEEAEEEEEEDEEEEE-----------EEEEEEEEEPQQRGQGEK 406

Query: 507 SPMSSLQISNEKNLEPGKQIS 527
           S   S +I +    EP   +S
Sbjct: 407 SATPSRKILDPNTGEPAPVLS 427



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 54/241 (22%), Positives = 92/241 (38%), Gaps = 46/241 (19%)

Query: 254 LKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKP-------GPDTFPDYGDVLRAVE 306
           L +   + G + E  +P  G  +P +    +     P         +TF + G V  A  
Sbjct: 200 LAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAET 259

Query: 307 KAAARH----SLG--LPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 360
               R     + G  L R +  +   DA R    +L+E   L+L +   C +  D    V
Sbjct: 260 LKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKE---LNLSF---CEIKRDAALAV 313

Query: 361 DPALSDPVLARRLRENRSL----AMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSH 416
             A++D     +L  N +        +L EV+  + M +                  +S 
Sbjct: 314 AEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKV----------------LASL 357

Query: 417 SADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEE--EEEEEATDSE 474
           S D  E   + GE     A +        E ++E++EE +EEEEE ++  + E+ AT S 
Sbjct: 358 SDDEDEEEEEEGEEEEEEAEE-----EEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSR 412

Query: 475 E 475
           +
Sbjct: 413 K 413



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 40/169 (23%), Positives = 68/169 (40%), Gaps = 18/169 (10%)

Query: 441 SASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAA 500
           + + A  D  + E+ D       EE  E+  +  E  ++ ++     DDE+E+EEEE   
Sbjct: 312 AVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEE--- 368

Query: 501 GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESN 560
              G++    + +   E   E  ++      E Q +G+    +  S + L P++      
Sbjct: 369 ---GEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT------ 419

Query: 561 GEQPEELTLEEESPVSQL--FELEIEALPLDTPSSV----ETDISSSRK 603
           GE    L+    + VS    F    + L L   SSV    +TD S   K
Sbjct: 420 GEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEK 468


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 63/261 (24%), Positives = 109/261 (41%), Gaps = 63/261 (24%)

Query: 408 ARLQGTSSHSADTPEASLDSGEGPSGMA--SQGCPSASRAETDDEDDEESDEEEEEEEEE 465
           A+   T      TP  +L +  G  G A  ++G  +   A+ +D D+EE D+ EE+EE++
Sbjct: 101 AKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDD 160

Query: 466 EEEE------------------ATDSEEEEDLEQMQEGQEDDEEEDEEEEA-----AAGK 502
           E+E+                  A++ E++ED ++  E  +DDEE+D EEEA     A GK
Sbjct: 161 EDEDEDEDEIEPAAMKAAAAAPASEDEDDED-DEDDEDDDDDEEDDSEEEAMETTPAKGK 219

Query: 503 DGDK-SPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNG 561
              K  P+ +  ++ +++ E   +      ++ ++                   D E + 
Sbjct: 220 KAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDE-----------------DDDDEDDE 262

Query: 562 EQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVS 621
           E+ EE   EEE PV             + P   + +++  +   E     V     G   
Sbjct: 263 EEEEE---EEEEPVK------------EAPGKRKKEMAKQKAAPEAKKQKV----EGTEP 303

Query: 622 STSFNGGVSPHNWGDSGPPCK 642
           +T+FN  V   N+  S P  K
Sbjct: 304 TTAFNLFVGNLNFNKSAPELK 324



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 33/164 (20%), Positives = 77/164 (46%), Gaps = 28/164 (17%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           K+ +  +K+     +   S   +  +   D  E     A+    +A+ A  D++D+++ D
Sbjct: 135 KNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDED 194

Query: 457 EEEEEEEEEE--EEEATDS------------------------EEEEDLEQMQEGQEDDE 490
           +E+++++EE+  EEEA ++                        EEE+D ++  +  EDDE
Sbjct: 195 DEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDE 254

Query: 491 EEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQ 534
           ++D+E++    ++ ++ P+   +   ++  E  KQ +    ++Q
Sbjct: 255 DDDDEDDEEEEEEEEEEPVK--EAPGKRKKEMAKQKAAPEAKKQ 296



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 40/144 (27%)

Query: 400 EGERKKRRARLQGTSSHSADTPEASLDSGEG---------PSGMASQGCPSASRAETDDE 450
           +G +  + A+ + +     D  E   +  E          P+ M +     AS  E D++
Sbjct: 132 KGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDED 191

Query: 451 D----DEESDEEEEEEE---------------------------EEEEEEATDSEEEEDL 479
           D    D++ DEE++ EE                           E+EEE+  D ++++D 
Sbjct: 192 DEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDE 251

Query: 480 EQMQEGQEDDEEEDEEEEAAAGKD 503
           +   +  EDDEEE+EEEE    K+
Sbjct: 252 DDEDDDDEDDEEEEEEEEEEPVKE 275



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 25/122 (20%), Positives = 59/122 (48%), Gaps = 3/122 (2%)

Query: 419 DTPEASLDSGEGPSGMASQGCPSASRAETDDED---DEESDEEEEEEEEEEEEEATDSEE 475
           D+ E ++++       A++  P  ++   +DED   D+E ++++++E++E++++  D EE
Sbjct: 205 DSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEE 264

Query: 476 EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQN 535
           EE+ E+    +   + + E  +  A  +  K  +   + +   NL  G      S  +  
Sbjct: 265 EEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELK 324

Query: 536 KG 537
            G
Sbjct: 325 TG 326


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 44/120 (36%), Positives = 60/120 (50%), Gaps = 5/120 (4%)

Query: 399 EEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEE 458
           E+G  +K             DT +A LD  E    MAS              + +E+ EE
Sbjct: 477 EQGVPEKEETPPPVEPEEEEDTEDAGLDDWEA---MASDEETEKVEGNKVHIEVKENPEE 533

Query: 459 EEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDE-EEEAAAGKDGDKSPMSSLQISNE 517
           EEEEEEEEEE+  +SEEEE+ E   EG E DEE+++  +E  +GK  DK P   +   +E
Sbjct: 534 EEEEEEEEEED-EESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 65/304 (21%), Positives = 125/304 (41%), Gaps = 55/304 (18%)

Query: 361 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSE-EGERKKRRARLQGTSSHSAD 419
           D +     +A++  E +     + DE  +K   L++K E E  +K +  + +       +
Sbjct: 220 DASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEE 279

Query: 420 TPEA--SLDSGEGPSGMASQGCPSASRAETDDEDDEESDE------EEEEEEEE------ 465
           T ++  ++D+G  P+       P+A  AE D+E D++  +      E+EE+E+E      
Sbjct: 280 TVKSKVTVDTGVIPASEEKAETPTA--AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPS 337

Query: 466 ---------------EEEEATDSEEEEDLEQMQ--EGQEDDEEEDEEEEAAAGKDGDKSP 508
                          EEEE    EEEE +++++  E +  +EE  E+E+    K  +K  
Sbjct: 338 KATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKE- 396

Query: 509 MSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSS---------IDAES 559
                   E+  + GK +++S  E + +       L ++    PS           + + 
Sbjct: 397 ------RKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKK 450

Query: 560 NGEQPEELTLEEESPVSQLFEL--EIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 617
             + P++L   E   VS+  EL   +E +    P   ET      ++ E+     L++  
Sbjct: 451 RKKIPQQL---ESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWE 507

Query: 618 GMVS 621
            M S
Sbjct: 508 AMAS 511



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 48/189 (25%), Positives = 90/189 (47%), Gaps = 30/189 (15%)

Query: 368 VLARRLRENRSLAMSRLD-------EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADT 420
           +L +  RE R+ A + L        EV SK ++ + +    ++K+++   Q  S   +++
Sbjct: 407 LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466

Query: 421 PE--ASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDS----- 473
            E  A+++  E       +  P     E +D +D   D+ E    +EE E+   +     
Sbjct: 467 MELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE 526

Query: 474 ------EEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEK------NLE 521
                 EEEE+ E+ +E +E +EEE+EE E + G +GD+      ++S+EK      + +
Sbjct: 527 VKENPEEEEEEEEEEEEDEESEEEEEEEGE-SEGSEGDE---EDEKVSDEKDSGKTLDKK 582

Query: 522 PGKQISRSS 530
           P K++S  S
Sbjct: 583 PSKEMSSDS 591



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 13/91 (14%)

Query: 446 ETDDEDDEESDEEEEE------EEEEEEEEATDSE------EEEDLEQMQEGQEDDEEED 493
           E ++ED+E  +EEEEE      E +EE+E+ +D +      +++  ++M    E D ++D
Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDD 598

Query: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGK 524
             +E  A  D  K  +   ++ + KN+   K
Sbjct: 599 RTKEERA-YDKAKRRIEKRRLEHSKNVNTEK 628



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 55/278 (19%), Positives = 117/278 (42%), Gaps = 46/278 (16%)

Query: 447 TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLE--------------QMQEGQEDDEEE 492
           T++ ++E + ++++++ ++ ++++ D  + E+LE              +M  G +DD++ 
Sbjct: 84  TENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDF 143

Query: 493 DEEEEAAAGK-------------DGDKS----PMSSLQISNEKNLEPGKQISRSSGEQQN 535
           ++  + A GK             D D S      S +  S E   E  + +    G+++N
Sbjct: 144 NKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKN 203

Query: 536 KGRIVSPSLLS--EEPLAPSSID--AESNGEQPEELTLEEESPVSQLFELEIEALPLDTP 591
           +     P++ S  E+  A   I   A+   E+ E    + +   ++L +L+ E   L+T 
Sbjct: 204 QKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK-EKEELETG 262

Query: 592 SSVET-DISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQ 650
              ++    S RK  EE   + +    G++ + S     +P    D     KK + +KK+
Sbjct: 263 KKDQSKQKESQRKFEEETVKSKVTVDTGVIPA-SEEKAETPTAAEDDNEGDKKKKDKKKK 321

Query: 651 TGSGPLGNSYVERQRSVHEKNGKKICTLPSPPSPLASL 688
            G         + ++   +K G    T+ +    LA L
Sbjct: 322 KGE--------KEEKEKEKKKGPSKATVKAMQEALAKL 351



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 14/90 (15%)

Query: 446 ETDDEDDEESDEEEEEE--------------EEEEEEEATDSEEEEDLEQMQEGQEDDEE 491
           E ++E+DEES+EEEEEE                +E++     +++   E   + + D ++
Sbjct: 538 EEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597

Query: 492 EDEEEEAAAGKDGDKSPMSSLQISNEKNLE 521
           +  +EE A  K   +     L+ S   N E
Sbjct: 598 DRTKEERAYDKAKRRIEKRRLEHSKNVNTE 627


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 56/206 (27%), Positives = 91/206 (44%), Gaps = 29/206 (14%)

Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499
           P    A    + + + +EEEEEE+EEEEEE    +EEE+ E+ +E +E++EEE+EEEEAA
Sbjct: 718 PQVPLAPVQPQANGKEEEEEEEEDEEEEEE----DEEEEEEEEEEEEEEEEEEEEEEEAA 773

Query: 500 AG---------KDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPL 550
           A          + G  S  S       +   P   ++    E + +  +    L  EE  
Sbjct: 774 AAVALGEVLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEE-- 831

Query: 551 APSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFT 610
              ++   S G+  +     E +P     + ++  L   TP       + S+    EP T
Sbjct: 832 GSKTLVLVSPGDMKKSPVTAELAP-----DPDLGTLAALTPQHERPQPTGSQLDVSEPGT 886

Query: 611 --TVLEN-------GAGMVSSTSFNG 627
             +VL++       GAG+ + T   G
Sbjct: 887 LSSVLKSEPKPPGPGAGLGAGTVTTG 912



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 61/270 (22%), Positives = 102/270 (37%), Gaps = 58/270 (21%)

Query: 377 RSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMAS 436
           RSL   R++   S+     D   E   ++ R  L G+ S  A + +        P+ M S
Sbjct: 447 RSLRYRRVNSPESERLSTADGRVELPERRSRMDLPGSPSRQACSSQ--------PAQMLS 498

Query: 437 QGCPSASRAETDDEDDEESDEEEE-----------EEEEEEEEEATDSEEEEDLEQMQEG 485
                A R  +   D   S E+E            EEE+ + +E    ++E +L+    G
Sbjct: 499 VDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPG 558

Query: 486 QE------DDEEEDE--------EEEAAAGKDGDKSPMS-SLQISNEKNLEP------GK 524
            E       DEE +E        EE    G +    P   S+Q   E++L+         
Sbjct: 559 AEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSMQALAEEDLQHLPPQPLPP 618

Query: 525 QISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFEL--- 581
           Q+S+  G  +   +  +P   S  PL         +G +P     +   P  Q+F +   
Sbjct: 619 QLSQGDGRSET-SQPPTPGSPSHSPL--------HSGPRPRRRESDPTGPQRQVFSVAPP 669

Query: 582 -EIEALPLDTPSSV-----ETDISSSRKQS 605
            E+  LP   P S+     + D+S  R+++
Sbjct: 670 FEVNGLPRAVPLSLPYQDFKRDLSDYRERA 699


>gi|218505694 potassium channel tetramerisation domain containing 1
           isoform b [Homo sapiens]
          Length = 865

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 51/175 (29%), Positives = 80/175 (45%), Gaps = 11/175 (6%)

Query: 412 GTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEAT 471
           G++S +A   E + + GEG  G   +G     R  +        +EEEEEEEE+E +E  
Sbjct: 16  GSASAAAAAAENNGERGEGERGAGGRG-----RRHSRPHYCSAGEEEEEEEEEDEIQEVQ 70

Query: 472 DSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSG 531
            + +EE+ E    G E+DEEE+EEEE     D    P  S     E   EP   I+    
Sbjct: 71  ITGDEEEEEDGGGGLEEDEEEEEEEEMGLDWDEPLEPEDS--AGEELEPEPVHMINMDQS 128

Query: 532 ---EQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEI 583
              E +   R+++P      P   S +D +   ++PE   L E + ++  + + I
Sbjct: 129 AALEPEAPPRLLAPRARGGPPGDGSELDPDVL-QRPERARLSENTRLATRYAVRI 182


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 88/383 (22%), Positives = 147/383 (38%), Gaps = 67/383 (17%)

Query: 394  LQDKSEEGERKKRRARLQGTSSHSADTPEA-----------SLDSGEGPSGMASQGCPSA 442
            + ++ EE ER++ R         +   P+             LDSG       S    S 
Sbjct: 987  VDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESL---SE 1043

Query: 443  SRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGK 502
             +  T++E++ E +EEEE++++++ ++  +SE +++   + E  E DE + +EEE  +  
Sbjct: 1044 EQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIV 1103

Query: 503  DGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNK--GRIVSPSLLSEEPLAPSSI----- 555
                   SS + S     E   + S SS E + +   R        EE +A  S+     
Sbjct: 1104 TSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGP 1163

Query: 556  -DAESNGEQP---------EELTLEEESPVSQLFELEIEAL-PLDTPSSVE--------T 596
             D E +GE+          + L +EEE       ++E EA+ P + PS ++         
Sbjct: 1164 EDFEQDGEEAALAPGAPAVDSLGMEEE------VDIETEAVAPEERPSMLDEPPLPVGVE 1217

Query: 597  DISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPL 656
            + + SR+  EEP   + + GA ++S         P    ++ PP    R  +      P 
Sbjct: 1218 EPADSREPPEEP--GLSQEGAMLLSPE------PPAKEVEARPPLSPERAPEHDLEVEPE 1269

Query: 657  GNSYVERQRSVHEKNGKKICTLPSPPSPL-------ASLAPVADSSTRVDSPSH--GLVT 707
                +           +     P PPSP        AS   V       D P H  GL  
Sbjct: 1270 PPMMLPLPLQPPLPPPRP----PRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCG 1325

Query: 708  SSLCIPSPARLSQTPHSQPPRPG 730
            S     S   +  TP  +PP  G
Sbjct: 1326 SLAKSQSTETVPATPGGEPPLSG 1348



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 75/352 (21%), Positives = 118/352 (33%), Gaps = 55/352 (15%)

Query: 431  PSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATD------------------ 472
            PS    +  P  + +  D +    S   +EE+EE E E   D                  
Sbjct: 960  PSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGV 1019

Query: 473  ---------------SEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNE 517
                            +E+E L + QE  E++EE +EEEE     D D       +  +E
Sbjct: 1020 RRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDE 1079

Query: 518  KNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPV 575
                 E  ++    S E++    + S +  +    +  S + ES+ E     + +EE  V
Sbjct: 1080 DTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVV 1139

Query: 576  SQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWG 635
            ++  E E E   +    S+ +      +Q  E     L  GA  V S      V      
Sbjct: 1140 AREEEEEEEEEEMVAEESMASAGPEDFEQDGE--EAALAPGAPAVDSLGMEEEVDI---- 1193

Query: 636  DSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKK----ICTLPSPPS-------P 684
            ++     + R         P+G       R   E+ G      +   P PP+       P
Sbjct: 1194 ETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPP 1253

Query: 685  LA-SLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTS 735
            L+   AP  D     + P   ++   L  P P      P S PP P T   S
Sbjct: 1254 LSPERAPEHDLEVEPEPPM--MLPLPLQPPLPPPRPPRPPSPPPEPETTDAS 1303


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
            sapiens]
          Length = 1152

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 49/182 (26%), Positives = 78/182 (42%), Gaps = 10/182 (5%)

Query: 395  QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454
            + + EEGE ++     +G         E   + GEG      +G       E ++E + E
Sbjct: 841  EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEG------EGEEEEGEGEGEEEGEGE 894

Query: 455  SDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGD---KSPMSS 511
             +EEE E E EEE E    EEE + +  +EG+E + E +EEE    G+DG+   +     
Sbjct: 895  GEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE 954

Query: 512  LQISNEKNLEPGKQISRSSGEQ-QNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLE 570
             +   E+    G++     GE+ + +G         EE       + E  GE+  E   E
Sbjct: 955  WEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGE 1014

Query: 571  EE 572
            EE
Sbjct: 1015 EE 1016



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 43/145 (29%), Positives = 64/145 (44%), Gaps = 5/145 (3%)

Query: 397 KSEEGERKKR-RARLQGTSSHSADTPEASLDSGEGPSGMASQGCP----SASRAETDDED 451
           + EEGERKK  RA  +       D  E   +  EG      +G           + + E+
Sbjct: 769 EKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREE 828

Query: 452 DEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511
           +EE  E EEEE E EEEE    EEE + +  +EG+E + EE+ EE    G++ +      
Sbjct: 829 EEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGE 888

Query: 512 LQISNEKNLEPGKQISRSSGEQQNK 536
            +   E   E G+      GE + +
Sbjct: 889 EEGEGEGEEEEGEGEGEEEGEGEGE 913



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 49/182 (26%), Positives = 79/182 (43%), Gaps = 12/182 (6%)

Query: 396 DKSEEGERKKRRARLQGTSSHSADTPEAS----LDSGEGPSGMASQGCPSASRAETDDED 451
           ++ E+GE+ K R  ++       +  E       D  E       QG       E ++  
Sbjct: 672 EEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG 731

Query: 452 DEESDEEEEEEEEEEEEEATDSEEEEDLE-QMQEGQEDDEEEDEEEEAAAGKDGDKSPMS 510
           +EE  E EEEE + EEEE  + E +E+ E +  EG+ + EE + ++E  AGK+ +K    
Sbjct: 732 EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE-EKGEEE 790

Query: 511 SLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLE 570
             Q   E+    G+      GE++ +G  V    + E        + E  GE+ E    E
Sbjct: 791 GDQGEGEEEETEGR------GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE 844

Query: 571 EE 572
           EE
Sbjct: 845 EE 846



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 43/150 (28%), Positives = 67/150 (44%), Gaps = 10/150 (6%)

Query: 395  QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454
            + + EEGE +      +G         E   + GEG      +G       E ++E+ E 
Sbjct: 931  EGEEEEGEGEGEDG--EGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEG 988

Query: 455  SDEEEEEEEE-------EEEEEATDSEEEE-DLEQMQEGQEDDEEEDEEEEAAAGKDGDK 506
              EEEE EEE       EEE E    EEEE ++E   EG+E + E +EEE    G++ +K
Sbjct: 989  EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREK 1048

Query: 507  SPMSSLQISNEKNLEPGKQISRSSGEQQNK 536
                     N +  E  +   + +GE++N+
Sbjct: 1049 EGEGEENRRNREEEEEEEGKYQETGEEENE 1078



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 53/197 (26%), Positives = 82/197 (41%), Gaps = 29/197 (14%)

Query: 395  QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454
            + + EEGE K      +G      +  E   + GEG  G   +G       E + E +EE
Sbjct: 911  EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG-EGEEEEGEWEGEEEEGEGEGEEE 969

Query: 455  SDEEEEE------------EEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGK 502
             + E EE            E EEEE E  + EEE + E+  EG+ ++EEE E E    G+
Sbjct: 970  GEGEGEEGEGEGEEEEGEGEGEEEEGE-EEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 1028

Query: 503  DGDKSPMSSLQISNEKNLEPGKQISR-SSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNG 561
            +G+       +   E+  E G++  +   GE+  + R        EE         E+  
Sbjct: 1029 EGEG------EGEEEEGEEEGEEREKEGEGEENRRNR--------EEEEEEEGKYQETGE 1074

Query: 562  EQPEELTLEEESPVSQL 578
            E+ E    EE   VS++
Sbjct: 1075 EENERQDGEEYKKVSKI 1091



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 48/186 (25%), Positives = 78/186 (41%), Gaps = 21/186 (11%)

Query: 395 QDKSEEGERKKRRARL-QGTSSHSADTPEASLDSGEGP------SGMASQGCPSASRAET 447
           + + EEG+R++   +  +G      +  E   +  EG       +G   +G     + E 
Sbjct: 737 EGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEG 796

Query: 448 DDEDDEESDEEEEEEEEEEEEEATDS-----EEEEDLEQMQEGQEDDEEEDE-EEEAAAG 501
           ++E+ E   EE+EE  E E  E  +      EEEE+ E  +E  E +EEE E EEE   G
Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG 856

Query: 502 KDGDKSPMSSLQISNEKNLEPG-KQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESN 560
           K  ++      +   E+    G ++     GE++ +G         EE       + E  
Sbjct: 857 KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGE-------GEEEEGEGEGEEEGE 909

Query: 561 GEQPEE 566
           GE  EE
Sbjct: 910 GEGEEE 915



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 42/163 (25%), Positives = 67/163 (41%), Gaps = 19/163 (11%)

Query: 400  EGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEE 459
            EGE ++     +G      +  E   +  E   G   +        E + E+ E   EEE
Sbjct: 978  EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE 1037

Query: 460  EEEEEEEEEEA----------TDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM 509
            E EEE EE E            + EEEE+ +  + G+E++E +D EE     K       
Sbjct: 1038 EGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSK-----IK 1092

Query: 510  SSLQISNEKNLEPGKQISRSSG---EQQNKGRIVSPSLLSEEP 549
             S++    K  +  K ++ + G   EQ++K  + S  LL   P
Sbjct: 1093 GSVKYGKHKTYQK-KSVTNTQGNGKEQRSKMPVQSKRLLKNGP 1134



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 40/184 (21%), Positives = 75/184 (40%), Gaps = 11/184 (5%)

Query: 386 EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRA 445
           EV    A    ++E+G   +     +  SS +    +   + GE   G      P     
Sbjct: 635 EVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEK 694

Query: 446 ETDDEDD---EESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGK 502
           E  ++++    + +E+E++E E+  ++  + E EE  E+     E++E + EEEE   G+
Sbjct: 695 ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE 754

Query: 503 DGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGE 562
              K      ++  E+  E G++       ++ KG         EE       + E  GE
Sbjct: 755 --GKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE------ETEGRGE 806

Query: 563 QPEE 566
           + EE
Sbjct: 807 EKEE 810



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 43/182 (23%), Positives = 74/182 (40%), Gaps = 8/182 (4%)

Query: 397 KSEEGERKKRRARLQG----TSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDD 452
           K  +GE ++++ R QG     +    +  E     GE   G   +        + + E +
Sbjct: 703 KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGE 762

Query: 453 EESDEEEEEEEEEEEEEATDSEE--EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMS 510
           E   E E+EE E ++EE    EE  EE+ +Q +  +E+ E   EE+E     +G +    
Sbjct: 763 EVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEG 822

Query: 511 SLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLE 570
             +   E+    G++      E++ +G         EE       + E  GE+ E    E
Sbjct: 823 KGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE--EGEEGEGEEEGEEGEGEGEE 880

Query: 571 EE 572
           EE
Sbjct: 881 EE 882



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 45/158 (28%), Positives = 70/158 (44%), Gaps = 32/158 (20%)

Query: 395  QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454
            + + EEGE +      +G         E   + GEG  G   +G       E ++E +EE
Sbjct: 947  EGEEEEGEWEGEEEEGEGEGEEEG---EGEGEEGEG-EGEEEEGEGEGEEEEGEEEGEEE 1002

Query: 455  SDEEEE-----EEEEE---------EEEEATDSEEE-----EDLEQMQEGQED--DEEED 493
             + EEE     EEEEE         EE E    EEE     E+ E+  EG+E+  + EE+
Sbjct: 1003 GEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEE 1062

Query: 494  EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSG 531
            EEEE    + G++        +  ++ E  K++S+  G
Sbjct: 1063 EEEEGKYQETGEEE-------NERQDGEEYKKVSKIKG 1093



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 55/247 (22%), Positives = 94/247 (38%), Gaps = 21/247 (8%)

Query: 447 TDDEDDEESDEEEEEEE--EEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDG 504
           T D    E+D+ +E EE  E +E +A      + +   Q     +   DEE E    K+G
Sbjct: 533 TQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEG 592

Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSE----EPLAPSSIDAESN 560
            +   S      E+ +E  ++  +  G ++ K  I+S  L  +    E  A S  +AE  
Sbjct: 593 AED--SKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDG 650

Query: 561 GEQPEELTLEEESPVSQLFELEIEAL--------PLDTPSSVETDISSS----RKQSEEP 608
            E   + T EE S  ++ ++ E             ++ P   E +++      ++  EE 
Sbjct: 651 PEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQ 710

Query: 609 FTTVLENGAGMVSSTSFN-GGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSV 667
                E G     +     GG   H  G+     ++  +EK+  G        VE +R  
Sbjct: 711 EQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREK 770

Query: 668 HEKNGKK 674
            E   KK
Sbjct: 771 EEGERKK 777



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 12/116 (10%)

Query: 423 ASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQM 482
           + +  G+      SQG      A T +   +E  E  EE+E  E+ +    EE+E     
Sbjct: 551 SEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQE----- 605

Query: 483 QEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGR 538
                   E +EE     G   +K+ + S  ++++  +  GK  S    E   +GR
Sbjct: 606 -------VEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGR 654


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           K E+ E +   + LQ  S     T  A   S E  SG       S    E ++E++EE  
Sbjct: 242 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 294

Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511
                EEEEEEEEEEEEE   + EE   +  +E  E++  EDEE E              
Sbjct: 295 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 340

Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569
               NE +L   P  +  R SGE +     V         L       +S    P EL  
Sbjct: 341 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 396

Query: 570 E 570
           E
Sbjct: 397 E 397



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 26/169 (15%)

Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453
           LQD S+  ERK   A      S S    E   +  E   G  S+   S    E ++E++E
Sbjct: 255 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 311

Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501
           E+    EE  E+  EE ++ E  ED E+  E            ++  E E+ EEE   G 
Sbjct: 312 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 371

Query: 502 ------KDGDKSP----MSSLQISNE-KNLEPGKQISRSSGEQQNKGRI 539
                  +GD  P    +S +++  E     P  Q  RS  E Q   RI
Sbjct: 372 PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 420



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449
           +++  E  RK+R AR +  S+H     E   D  +      S   P   R E  D     
Sbjct: 183 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 241

Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507
             E  EE D   + ++  + E  T S E    E     +E++EEE+EEEE  +  +  + 
Sbjct: 242 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 301

Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563
                +   E+     ++ S  S E+ ++  +        E     +  S  D +S   +
Sbjct: 302 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 361

Query: 564 PEELTLEEESPVS 576
             E  + E +P S
Sbjct: 362 EAEEEVGEGTPQS 374



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 48/230 (20%), Positives = 91/230 (39%), Gaps = 13/230 (5%)

Query: 390 KYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD 449
           K+A +++K  E ER+KR    Q  +    +  +      E     + +      + E   
Sbjct: 109 KHARVKEKEREHERRKRHREEQDKARREWERQKRR----EMAREHSRRERDRLEQLERKR 164

Query: 450 EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQE--GQEDDEEEDEEEEAAA---GKDG 504
           E + +  E+++E+ E++E E    E  ++ E  +E         ED  ++  A    +  
Sbjct: 165 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 224

Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQP 564
            + P    ++ + +  +P K+      +  +  + +S S         SS ++ S  E+ 
Sbjct: 225 PRPPRERFELGDGR--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 282

Query: 565 EELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLE 614
           EE   EEE   S   E E E    +     E   S+S + SE+    V E
Sbjct: 283 EEEEEEEEEEGSTSEESEEE--EEEEEEEEEETGSNSEEASEQSAEEVSE 330



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 39/182 (21%), Positives = 75/182 (41%), Gaps = 25/182 (13%)

Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGE-GPSG 433
           E  S  +  LDE++ +    +++ E+ E K+ +      +S   D+   SL+ GE     
Sbjct: 4   EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLK------NSDDRDSKRDSLEEGELRDHC 57

Query: 434 MASQGCPSASRAETDDEDDEESDE-----------------EEEEEEEEEEEEATDSEEE 476
           M      S  R E   ED  E D+                   ++E+ +E++ A   E+E
Sbjct: 58  MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKE 117

Query: 477 EDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNK 536
            + E+ +  +E+ ++   E E    ++  +   S  +    + LE  ++  R   EQQ +
Sbjct: 118 REHERRKRHREEQDKARREWERQKRREMARE-HSRRERDRLEQLERKRERERKMREQQKE 176

Query: 537 GR 538
            R
Sbjct: 177 QR 178



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 51/242 (21%), Positives = 89/242 (36%), Gaps = 26/242 (10%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASL-DSGEGPSGMASQGCPSASRAET----DD 449
           +D  EEGE +     +  T  +S    E S+ D GE    +A +     SR E      D
Sbjct: 45  RDSLEEGELRDHCMEI--TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102

Query: 450 EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM 509
           E  +E      +E+E E E      EE+D     + + + E +   E A      ++  +
Sbjct: 103 EKRKEKKHARVKEKEREHERRKRHREEQD-----KARREWERQKRREMAREHSRRERDRL 157

Query: 510 SSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSI------DAESNGEQ 563
             L+   E+  +  +Q  +   EQ+ + R         E     S       +  S+  +
Sbjct: 158 EQLERKRERERKMREQ-QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 216

Query: 564 PEELTLEEESPVSQLFELEIEALPLDTPSSVE-------TDISSSRKQSEEPFTTVLENG 616
               +     P  + FEL     P+      E        DIS S +++    ++  E+G
Sbjct: 217 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 276

Query: 617 AG 618
           +G
Sbjct: 277 SG 278


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           K E+ E +   + LQ  S     T  A   S E  SG       S    E ++E++EE  
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 303

Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511
                EEEEEEEEEEEEE   + EE   +  +E  E++  EDEE E              
Sbjct: 304 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 349

Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569
               NE +L   P  +  R SGE +     V         L       +S    P EL  
Sbjct: 350 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 405

Query: 570 E 570
           E
Sbjct: 406 E 406



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 60/268 (22%), Positives = 103/268 (38%), Gaps = 26/268 (9%)

Query: 298 YGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYR 357
           + D L  +E+   R      +Q+ Q   ++  R    R +ER     +      + +DY 
Sbjct: 162 FRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS 221

Query: 358 PGVDPALSDPVLARRLRENRSLAMSRL---DEVISKYAMLQDKSEEGERKKRRARLQGTS 414
             V  +       R  RE   L   R    +E + +  +L D  +  + +++ +  + +S
Sbjct: 222 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS 281

Query: 415 SHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSE 474
           + S    E   +  E      S    S    E ++E++EE+    EE  E+  EE ++ E
Sbjct: 282 AESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEE 341

Query: 475 EEEDLEQMQEG-----------QEDDEEEDEEEEAAAG-------KDGDKSP----MSSL 512
             ED E+  E            ++  E E+ EEE   G        +GD  P    +S +
Sbjct: 342 MSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI 401

Query: 513 QISNE-KNLEPGKQISRSSGEQQNKGRI 539
           ++  E     P  Q  RS  E Q   RI
Sbjct: 402 ELKQELPKYLPALQGCRSVEEFQCLNRI 429



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 42/193 (21%), Positives = 74/193 (38%), Gaps = 12/193 (6%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454
           +++  E  RK+R AR +  S+H     E   D  +      S   P   R E  D     
Sbjct: 192 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 250

Query: 455 SDEEEEEEEEEEE-EEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQ 513
            +E+ EE +   + ++ +DSE +    +    +     E+EEEE    ++   +   S +
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 310

Query: 514 ISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEP----------LAPSSIDAESNGEQ 563
              E+  E  +  S S    +     VS   +SE+           +  S  D +S   +
Sbjct: 311 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 370

Query: 564 PEELTLEEESPVS 576
             E  + E +P S
Sbjct: 371 EAEEEVGEGTPQS 383



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 50/239 (20%), Positives = 90/239 (37%), Gaps = 22/239 (9%)

Query: 390 KYAMLQDKSEEGERKKR------RARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSAS 443
           K+A +++K  E ER+KR      +AR +       +          G  G+    C    
Sbjct: 109 KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGV----CLFRD 164

Query: 444 RAE-----TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEA 498
           R E      + E      ++E+ E++E E  A +  +E +  +          ED  ++ 
Sbjct: 165 RLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKV 224

Query: 499 AA---GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSI 555
            A    +   + P    ++ + +  +P K+      +  +  + +S S         SS 
Sbjct: 225 KASHWSRSPPRPPRERFELGDGR--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 282

Query: 556 DAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLE 614
           ++ S  E+ EE   EEE   S   E E E    +     E   S+S + SE+    V E
Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEESEEE--EEEEEEEEEETGSNSEEASEQSAEEVSE 339



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 39/150 (26%), Positives = 59/150 (39%), Gaps = 13/150 (8%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASL-DSGEGPSGMASQGCPSASRAET-----D 448
           +D  EEGE +     +  T  +S    E S+ D GE    +A +     SR E      D
Sbjct: 45  RDSLEEGELRDHCMEI--TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102

Query: 449 DEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSP 508
           ++  E+     +E+E E E      EE++   +  E Q+  E   E      G DG    
Sbjct: 103 EKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDG---- 158

Query: 509 MSSLQISNEKNLEPGKQISRSSGEQQNKGR 538
              L     + LE  ++  R   EQQ + R
Sbjct: 159 -VCLFRDRLEQLERKRERERKMREQQKEQR 187


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           K E+ E +   + LQ  S     T  A   S E  SG       S    E ++E++EE  
Sbjct: 219 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 271

Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511
                EEEEEEEEEEEEE   + EE   +  +E  E++  EDEE E              
Sbjct: 272 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 317

Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569
               NE +L   P  +  R SGE +     V         L       +S    P EL  
Sbjct: 318 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 373

Query: 570 E 570
           E
Sbjct: 374 E 374



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 26/169 (15%)

Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453
           LQD S+  ERK   A      S S    E   +  E   G  S+   S    E ++E++E
Sbjct: 232 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 288

Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501
           E+    EE  E+  EE ++ E  ED E+  E            ++  E E+ EEE   G 
Sbjct: 289 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 348

Query: 502 ------KDGDKSP----MSSLQISNE-KNLEPGKQISRSSGEQQNKGRI 539
                  +GD  P    +S +++  E     P  Q  RS  E Q   RI
Sbjct: 349 PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 397



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449
           +++  E  RK+R AR +  S+H     E   D  +      S   P   R E  D     
Sbjct: 160 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 218

Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507
             E  EE D   + ++  + E  T S E    E     +E++EEE+EEEE  +  +  + 
Sbjct: 219 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 278

Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563
                +   E+     ++ S  S E+ ++  +        E     +  S  D +S   +
Sbjct: 279 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 338

Query: 564 PEELTLEEESPVS 576
             E  + E +P S
Sbjct: 339 EAEEEVGEGTPQS 351



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 48/230 (20%), Positives = 91/230 (39%), Gaps = 13/230 (5%)

Query: 390 KYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD 449
           K+A +++K  E ER+KR    Q  +    +  +      E     + +      + E   
Sbjct: 86  KHARVKEKEREHERRKRHREEQDKARREWERQKRR----EMAREHSRRERDRLEQLERKR 141

Query: 450 EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQE--GQEDDEEEDEEEEAAA---GKDG 504
           E + +  E+++E+ E++E E    E  ++ E  +E         ED  ++  A    +  
Sbjct: 142 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 201

Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQP 564
            + P    ++ + +  +P K+      +  +  + +S S         SS ++ S  E+ 
Sbjct: 202 PRPPRERFELGDGR--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 259

Query: 565 EELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLE 614
           EE   EEE   S   E E E    +     E   S+S + SE+    V E
Sbjct: 260 EEEEEEEEEEGSTSEESEEE--EEEEEEEEEETGSNSEEASEQSAEEVSE 307


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           K E+ E +   + LQ  S     T  A   S E  SG       S    E ++E++EE  
Sbjct: 208 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 260

Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511
                EEEEEEEEEEEEE   + EE   +  +E  E++  EDEE E              
Sbjct: 261 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 306

Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569
               NE +L   P  +  R SGE +     V         L       +S    P EL  
Sbjct: 307 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 362

Query: 570 E 570
           E
Sbjct: 363 E 363



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 26/169 (15%)

Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453
           LQD S+  ERK   A      S S    E   +  E   G  S+   S    E ++E++E
Sbjct: 221 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 277

Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501
           E+    EE  E+  EE ++ E  ED E+  E            ++  E E+ EEE   G 
Sbjct: 278 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 337

Query: 502 ------KDGDKSP----MSSLQISNE-KNLEPGKQISRSSGEQQNKGRI 539
                  +GD  P    +S +++  E     P  Q  RS  E Q   RI
Sbjct: 338 PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 386



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449
           +++  E  RK+R AR +  S+H     E   D  +      S   P   R E  D     
Sbjct: 149 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 207

Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507
             E  EE D   + ++  + E  T S E    E     +E++EEE+EEEE  +  +  + 
Sbjct: 208 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 267

Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563
                +   E+     ++ S  S E+ ++  +        E     +  S  D +S   +
Sbjct: 268 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 327

Query: 564 PEELTLEEESPVS 576
             E  + E +P S
Sbjct: 328 EAEEEVGEGTPQS 340



 Score = 34.3 bits (77), Expect = 0.44
 Identities = 59/267 (22%), Positives = 101/267 (37%), Gaps = 37/267 (13%)

Query: 381 MSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASL-DSGEGPSGMASQGC 439
           MS+ D+  SK    +D  EEGE +  R  +  T  +S    E S+ D GE    +A +  
Sbjct: 1   MSQSDDRDSK----RDSLEEGELRDHRMEI--TIRNSPYRREDSMEDRGEEDDSLAIKPP 54

Query: 440 PSASRAET-----DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDE---- 490
              SR E      D++  E+     +E+E E E      EE++   +  E Q+  E    
Sbjct: 55  QQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMARE 114

Query: 491 ----EEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRI------- 539
               E D  E+    ++ ++  M   Q    +  E  ++      E++ +  +       
Sbjct: 115 HSRRERDRLEQLERKRERERK-MREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 173

Query: 540 -------VSPSLLSEEPLAPSSIDAE-SNGEQP-EELTLEEESPVSQLFELEIEALPLDT 590
                  V  S  S  P  P     E  +G +P +E  +EE   +S L ++        +
Sbjct: 174 REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS 233

Query: 591 PSSVETDISSSRKQSEEPFTTVLENGA 617
             S   +  S  ++ EE      E G+
Sbjct: 234 AESSSAESGSGSEEEEEEEEEEEEEGS 260


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           K E+ E +   + LQ  S     T  A   S E  SG       S    E ++E++EE  
Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 305

Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511
                EEEEEEEEEEEEE   + EE   +  +E  E++  EDEE E              
Sbjct: 306 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 351

Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569
               NE +L   P  +  R SGE +     V         L       +S    P EL  
Sbjct: 352 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 407

Query: 570 E 570
           E
Sbjct: 408 E 408



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 26/169 (15%)

Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453
           LQD S+  ERK   A      S S    E   +  E   G  S+   S    E ++E++E
Sbjct: 266 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 322

Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501
           E+    EE  E+  EE ++ E  ED E+  E            ++  E E+ EEE   G 
Sbjct: 323 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 382

Query: 502 ------KDGDKSP----MSSLQISNE-KNLEPGKQISRSSGEQQNKGRI 539
                  +GD  P    +S +++  E     P  Q  RS  E Q   RI
Sbjct: 383 PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 431



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449
           +++  E  RK+R AR +  S+H     E   D  +      S   P   R E  D     
Sbjct: 194 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 252

Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507
             E  EE D   + ++  + E  T S E    E     +E++EEE+EEEE  +  +  + 
Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 312

Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563
                +   E+     ++ S  S E+ ++  +        E     +  S  D +S   +
Sbjct: 313 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 372

Query: 564 PEELTLEEESPVS 576
             E  + E +P S
Sbjct: 373 EAEEEVGEGTPQS 385



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 48/230 (20%), Positives = 91/230 (39%), Gaps = 13/230 (5%)

Query: 390 KYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD 449
           K+A +++K  E ER+KR    Q  +    +  +      E     + +      + E   
Sbjct: 120 KHARVKEKEREHERRKRHREEQDKARREWERQKRR----EMAREHSRRERDRLEQLERKR 175

Query: 450 EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQE--GQEDDEEEDEEEEAAA---GKDG 504
           E + +  E+++E+ E++E E    E  ++ E  +E         ED  ++  A    +  
Sbjct: 176 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 235

Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQP 564
            + P    ++ + +  +P K+      +  +  + +S S         SS ++ S  E+ 
Sbjct: 236 PRPPRERFELGDGR--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 293

Query: 565 EELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLE 614
           EE   EEE   S   E E E    +     E   S+S + SE+    V E
Sbjct: 294 EEEEEEEEEEGSTSEESEEE--EEEEEEEEEETGSNSEEASEQSAEEVSE 341


>gi|115529449 upstream binding transcription factor, RNA polymerase
           I isoform b [Homo sapiens]
          Length = 727

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 8/101 (7%)

Query: 424 SLDSGEGPSGMASQGC-PSASRAETDDEDDEESDEEEEEEEEEEE----EEATDSEE--- 475
           S+    GP+  +S+    S S +E DDE+DE+ ++E+EEEE++E     E+  DS E   
Sbjct: 618 SMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSS 677

Query: 476 EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516
           E++ E   E +EDDE+ED++E+    +D +    SS   S+
Sbjct: 678 EDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 718



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 34/130 (26%), Positives = 51/130 (39%), Gaps = 17/130 (13%)

Query: 386 EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSAS-- 443
           E IS       K      K  R  LQ  S    D  E   D  E       +   S+   
Sbjct: 610 EYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDG 669

Query: 444 --RAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAG 501
              +E+  ED+ E  +E EE++E+E     D +E++D        ED++ E E   +++ 
Sbjct: 670 GDSSESSSEDESEDGDENEEDDEDE-----DDDEDDD--------EDEDNESEGSSSSSS 716

Query: 502 KDGDKSPMSS 511
             GD S   S
Sbjct: 717 SSGDSSDSDS 726



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/121 (24%), Positives = 50/121 (41%), Gaps = 20/121 (16%)

Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499
           P +SR     + + E D+EE+E++E+E+EE                +EDDE  D  E+  
Sbjct: 627 PKSSRTTLQSKSESEEDDEEDEDDEDEDEE----------------EEDDENGDSSEDGG 670

Query: 500 AGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAES 559
              +      S     NE++ E          ++ N+    S S  S    +  S D++S
Sbjct: 671 DSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS----SGDSSDSDS 726

Query: 560 N 560
           N
Sbjct: 727 N 727



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 24/99 (24%), Positives = 42/99 (42%)

Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGM 434
           + +S+   R     S    LQ KSE  E  +     +       D          G S  
Sbjct: 615 KRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSE 674

Query: 435 ASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDS 473
           +S    S    E +++D++E D+E+++E+E+ E E + S
Sbjct: 675 SSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSS 713



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 2/84 (2%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454
           +D+ +E E ++      G SS   D  ++S  S E  S    +        + D++DDE+
Sbjct: 646 EDEDDEDEDEEEEDDENGDSSE--DGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 703

Query: 455 SDEEEEEEEEEEEEEATDSEEEED 478
            D E E            S+ + +
Sbjct: 704 EDNESEGSSSSSSSSGDSSDSDSN 727


>gi|115529451 upstream binding transcription factor, RNA polymerase
           I isoform b [Homo sapiens]
          Length = 727

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 8/101 (7%)

Query: 424 SLDSGEGPSGMASQGC-PSASRAETDDEDDEESDEEEEEEEEEEE----EEATDSEE--- 475
           S+    GP+  +S+    S S +E DDE+DE+ ++E+EEEE++E     E+  DS E   
Sbjct: 618 SMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSS 677

Query: 476 EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516
           E++ E   E +EDDE+ED++E+    +D +    SS   S+
Sbjct: 678 EDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 718



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 34/130 (26%), Positives = 51/130 (39%), Gaps = 17/130 (13%)

Query: 386 EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSAS-- 443
           E IS       K      K  R  LQ  S    D  E   D  E       +   S+   
Sbjct: 610 EYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDG 669

Query: 444 --RAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAG 501
              +E+  ED+ E  +E EE++E+E     D +E++D        ED++ E E   +++ 
Sbjct: 670 GDSSESSSEDESEDGDENEEDDEDE-----DDDEDDD--------EDEDNESEGSSSSSS 716

Query: 502 KDGDKSPMSS 511
             GD S   S
Sbjct: 717 SSGDSSDSDS 726



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/121 (24%), Positives = 50/121 (41%), Gaps = 20/121 (16%)

Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499
           P +SR     + + E D+EE+E++E+E+EE                +EDDE  D  E+  
Sbjct: 627 PKSSRTTLQSKSESEEDDEEDEDDEDEDEE----------------EEDDENGDSSEDGG 670

Query: 500 AGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAES 559
              +      S     NE++ E          ++ N+    S S  S    +  S D++S
Sbjct: 671 DSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS----SGDSSDSDS 726

Query: 560 N 560
           N
Sbjct: 727 N 727



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 24/99 (24%), Positives = 42/99 (42%)

Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGM 434
           + +S+   R     S    LQ KSE  E  +     +       D          G S  
Sbjct: 615 KRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSE 674

Query: 435 ASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDS 473
           +S    S    E +++D++E D+E+++E+E+ E E + S
Sbjct: 675 SSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSS 713



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 2/84 (2%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454
           +D+ +E E ++      G SS   D  ++S  S E  S    +        + D++DDE+
Sbjct: 646 EDEDDEDEDEEEEDDENGDSSE--DGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 703

Query: 455 SDEEEEEEEEEEEEEATDSEEEED 478
            D E E            S+ + +
Sbjct: 704 EDNESEGSSSSSSSSGDSSDSDSN 727


>gi|7657671 upstream binding transcription factor, RNA polymerase I
           isoform a [Homo sapiens]
          Length = 764

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 8/101 (7%)

Query: 424 SLDSGEGPSGMASQGC-PSASRAETDDEDDEESDEEEEEEEEEEE----EEATDSEE--- 475
           S+    GP+  +S+    S S +E DDE+DE+ ++E+EEEE++E     E+  DS E   
Sbjct: 655 SMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSS 714

Query: 476 EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516
           E++ E   E +EDDE+ED++E+    +D +    SS   S+
Sbjct: 715 EDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 755



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 34/130 (26%), Positives = 51/130 (39%), Gaps = 17/130 (13%)

Query: 386 EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSAS-- 443
           E IS       K      K  R  LQ  S    D  E   D  E       +   S+   
Sbjct: 647 EYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDG 706

Query: 444 --RAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAG 501
              +E+  ED+ E  +E EE++E+E     D +E++D        ED++ E E   +++ 
Sbjct: 707 GDSSESSSEDESEDGDENEEDDEDE-----DDDEDDD--------EDEDNESEGSSSSSS 753

Query: 502 KDGDKSPMSS 511
             GD S   S
Sbjct: 754 SSGDSSDSDS 763



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 30/121 (24%), Positives = 50/121 (41%), Gaps = 20/121 (16%)

Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499
           P +SR     + + E D+EE+E++E+E+EE                +EDDE  D  E+  
Sbjct: 664 PKSSRTTLQSKSESEEDDEEDEDDEDEDEE----------------EEDDENGDSSEDGG 707

Query: 500 AGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAES 559
              +      S     NE++ E          ++ N+    S S  S    +  S D++S
Sbjct: 708 DSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS----SGDSSDSDS 763

Query: 560 N 560
           N
Sbjct: 764 N 764



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 24/99 (24%), Positives = 42/99 (42%)

Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGM 434
           + +S+   R     S    LQ KSE  E  +     +       D          G S  
Sbjct: 652 KRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSE 711

Query: 435 ASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDS 473
           +S    S    E +++D++E D+E+++E+E+ E E + S
Sbjct: 712 SSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSS 750



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 2/84 (2%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454
           +D+ +E E ++      G SS   D  ++S  S E  S    +        + D++DDE+
Sbjct: 683 EDEDDEDEDEEEEDDENGDSSE--DGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 740

Query: 455 SDEEEEEEEEEEEEEATDSEEEED 478
            D E E            S+ + +
Sbjct: 741 EDNESEGSSSSSSSSGDSSDSDSN 764


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           K E+ E +   + LQ  S     T  A   S E  SG       S    E ++E++EE  
Sbjct: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 293

Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511
                EEEEEEEEEEEEE   + EE   +  +E  E++  EDEE E              
Sbjct: 294 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 339

Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569
               NE +L   P  +  R SGE +     V         L       +S    P EL  
Sbjct: 340 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ 395

Query: 570 E 570
           E
Sbjct: 396 E 396



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 49/169 (28%), Positives = 66/169 (39%), Gaps = 26/169 (15%)

Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453
           LQD S+  ERK   A      S S    E   +  E   G  S+   S    E ++E++E
Sbjct: 254 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 310

Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501
           E+    EE  E+  EE ++ E  ED E+  E            ++  E E+ EEE   G 
Sbjct: 311 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 370

Query: 502 ------KDGDKSPMSSLQISNEKNLE-----PGKQISRSSGEQQNKGRI 539
                  +GD  P S   +  E   E     P  Q  RS  E Q   RI
Sbjct: 371 PQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRI 419



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449
           +++  E  RK+R AR +  S+H     E   D  +      S   P   R E  D     
Sbjct: 182 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 240

Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507
             E  EE D   + ++  + E  T S E    E     +E++EEE+EEEE  +  +  + 
Sbjct: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 300

Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563
                +   E+     ++ S  S E+ ++  +        E     +  S  D +S   +
Sbjct: 301 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 360

Query: 564 PEELTLEEESPVS 576
             E  + E +P S
Sbjct: 361 EAEEEVGEGTPQS 373



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 57/257 (22%), Positives = 92/257 (35%), Gaps = 29/257 (11%)

Query: 395 QDKSE-EGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453
           QDK+  E ER+KRR   +  S    D  E      E    M  Q      + E +   +E
Sbjct: 129 QDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 188

Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLE----------------QMQEGQEDDEEEDEEEE 497
              E E   E          +  + ++                ++ +G++  +EE  EE 
Sbjct: 189 RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER 248

Query: 498 AAAGKDGDKS----PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPS 553
                  D S      SS + S+ ++    ++      E++ +G     S   EE     
Sbjct: 249 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEE 308

Query: 554 SIDAESNGEQPEELTLEE--ESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTT 611
             +  SN E+  E + EE  E  +S+  E E E   L  P S     S   +++EE    
Sbjct: 309 EEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE---- 364

Query: 612 VLENGAGMVSSTSFNGG 628
             E G G   S++   G
Sbjct: 365 --EVGEGTPQSSALTEG 379



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 36/180 (20%), Positives = 74/180 (41%), Gaps = 22/180 (12%)

Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGE-GPSG 433
           E  S  +  LDE++ +    +++ E+ E K+ +      +S   D+   SL+ GE     
Sbjct: 4   EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLK------NSDDRDSKRDSLEEGELRDHC 57

Query: 434 MASQGCPSASRAETDDEDDEESDEE------EEEEEEEEEEEATDSEEEEDLE--QMQEG 485
           M      S  R E   ED  E D+       ++   +E+     D + +E  +  +++E 
Sbjct: 58  MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKER 117

Query: 486 QEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEK-------NLEPGKQISRSSGEQQNKGR 538
           + +  +   EE+  A ++ ++     +   + +        LE  ++  R   EQQ + R
Sbjct: 118 EHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 177


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%)

Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456
           K E+ E +   + LQ  S     T  A   S E  SG       S    E ++E++EE  
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 303

Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511
                EEEEEEEEEEEEE   + EE   +  +E  E++  EDEE E              
Sbjct: 304 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 349

Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569
               NE +L   P  +  R SGE +     V         L       +S    P EL  
Sbjct: 350 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ 405

Query: 570 E 570
           E
Sbjct: 406 E 406



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 49/169 (28%), Positives = 66/169 (39%), Gaps = 26/169 (15%)

Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453
           LQD S+  ERK   A      S S    E   +  E   G  S+   S    E ++E++E
Sbjct: 264 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 320

Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501
           E+    EE  E+  EE ++ E  ED E+  E            ++  E E+ EEE   G 
Sbjct: 321 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 380

Query: 502 ------KDGDKSPMSSLQISNEKNLE-----PGKQISRSSGEQQNKGRI 539
                  +GD  P S   +  E   E     P  Q  RS  E Q   RI
Sbjct: 381 PQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRI 429



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%)

Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449
           +++  E  RK+R AR +  S+H     E   D  +      S   P   R E  D     
Sbjct: 192 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 250

Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507
             E  EE D   + ++  + E  T S E    E     +E++EEE+EEEE  +  +  + 
Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 310

Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563
                +   E+     ++ S  S E+ ++  +        E     +  S  D +S   +
Sbjct: 311 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 370

Query: 564 PEELTLEEESPVS 576
             E  + E +P S
Sbjct: 371 EAEEEVGEGTPQS 383



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 57/257 (22%), Positives = 92/257 (35%), Gaps = 29/257 (11%)

Query: 395 QDKSE-EGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453
           QDK+  E ER+KRR   +  S    D  E      E    M  Q      + E +   +E
Sbjct: 139 QDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 198

Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLE----------------QMQEGQEDDEEEDEEEE 497
              E E   E          +  + ++                ++ +G++  +EE  EE 
Sbjct: 199 RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER 258

Query: 498 AAAGKDGDKS----PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPS 553
                  D S      SS + S+ ++    ++      E++ +G     S   EE     
Sbjct: 259 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEE 318

Query: 554 SIDAESNGEQPEELTLEE--ESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTT 611
             +  SN E+  E + EE  E  +S+  E E E   L  P S     S   +++EE    
Sbjct: 319 EEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE---- 374

Query: 612 VLENGAGMVSSTSFNGG 628
             E G G   S++   G
Sbjct: 375 --EVGEGTPQSSALTEG 389


>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo
           sapiens]
          Length = 1341

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 78/335 (23%), Positives = 139/335 (41%), Gaps = 42/335 (12%)

Query: 301 VLRAVEKAAARHSLGLPRQQL-QLMAQDAFRDVGIRLQE---RRHLDLIYNFGCHLTDDY 356
           +L  ++K +  H+   P  Q+ + M+Q++F    +  Q+   R+ L+        L +  
Sbjct: 107 MLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEAS 166

Query: 357 RPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYA------MLQDKSEEGERKKRRARL 410
               D  +    +A  L  +   ++ R +  +S+++      + ++K +  + K R+   
Sbjct: 167 AESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGER 226

Query: 411 QGTSSHSADTPEASLDSGEGPSGMAS-QGCPSAS-------RAETDDEDDEESDEEEEEE 462
           +  SS       A L  G  P+     Q  PS +         +T++E++EE +EEE++E
Sbjct: 227 R--SSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDE 284

Query: 463 EEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEP 522
           EEE ++E   S E   L++ +E  E+      EE        D+ P +  Q   ++ LE 
Sbjct: 285 EEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMM------DERPKTRSQ--EQEVLER 336

Query: 523 GKQISRSSGE---------QQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEES 573
           G + +RS  E         QQ K    +  L  EE    SS   +   + P    L E+ 
Sbjct: 337 GGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR 396

Query: 574 PVSQLFELEIEALPLDTPSSVETDISSSRKQSEEP 608
             + L      ALP  T S  ET      K++  P
Sbjct: 397 KKASLV-----ALPEQTASEEETPPPLLTKEASSP 426



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 9/98 (9%)

Query: 442  ASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAG 501
            A RAE   E ++   E+EEEE++E E+EA + E    LE+ ++ +E   E D E E    
Sbjct: 1239 AERAERAKEREKRRKEQEEEEQKEREKEA-ERERNRQLER-EKRREHSRERDRERERERE 1296

Query: 502  KD-GDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGR 538
            +D GD+          E++ E G++  R   ++ ++ R
Sbjct: 1297 RDRGDRDR------DRERDRERGRERDRRDTKRHSRSR 1328



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 37/174 (21%), Positives = 72/174 (41%), Gaps = 16/174 (9%)

Query: 400  EGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEE 459
            EG +  R+ R   +++ +   P  S+ + E    +     P A +    D   ++S   E
Sbjct: 841  EGGQPGRKRRWGASTATTQKKPSISITT-ESLKSLIPDIKPLAGQEAVVDLHADDSRISE 899

Query: 460  EEEEEEEEEEATDSEEEEDLEQMQ----EGQEDDEEEDEEEEAAAGKDGDKSPMSSLQIS 515
            +E E   ++   D   +      Q    EGQE+ + E+EEEE     +    P  S++++
Sbjct: 900  DETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVA 959

Query: 516  -------NEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGE 562
                     K +  G  ++R S  QQ  G     S+  ++P+  + + +   G+
Sbjct: 960  LPPPAEHEVKKVTLGDTLTRRSISQQKSG----VSITIDDPVRTAQVPSPPRGK 1009



 Score = 33.5 bits (75), Expect = 0.75
 Identities = 18/67 (26%), Positives = 29/67 (43%)

Query: 440  PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499
            P   RAE  +++    ++  E E E E  E T SE E D ++++EG        +     
Sbjct: 1128 PQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKE 1187

Query: 500  AGKDGDK 506
              K  +K
Sbjct: 1188 RAKSKEK 1194



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 15/67 (22%), Positives = 38/67 (56%)

Query: 467  EEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQI 526
            ++EA  +E  ++ E+ ++ QE++E+++ E+EA   ++         + S E++ E  ++ 
Sbjct: 1236 QKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERER 1295

Query: 527  SRSSGEQ 533
             R  G++
Sbjct: 1296 ERDRGDR 1302


>gi|21361639 DIPB protein [Homo sapiens]
          Length = 344

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 38/135 (28%), Positives = 67/135 (49%), Gaps = 6/135 (4%)

Query: 422 EASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQ 481
           E  ++S  G    + +   S   +ET++E ++ESDEE EE+ EEE E+  +SE EED   
Sbjct: 88  EREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEED--- 144

Query: 482 MQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVS 541
               QE+ E E E E  A  +   +  M + +++  K  + G  +S    E +    ++ 
Sbjct: 145 ---NQEEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLSTYCQEDRQLICVLC 201

Query: 542 PSLLSEEPLAPSSID 556
           P + + +    S++D
Sbjct: 202 PVIGAHQGHQLSTLD 216



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/79 (36%), Positives = 46/79 (58%), Gaps = 1/79 (1%)

Query: 444 RAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEE-DEEEEAAAGK 502
           + E + E + E+ EE E EEE E EE +++EEE + E  +E +ED EEE ++E+E+ A +
Sbjct: 84  KVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEE 143

Query: 503 DGDKSPMSSLQISNEKNLE 521
           D  +   S  +   E   E
Sbjct: 144 DNQEEGESEAEGETEAESE 162



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 39/109 (35%), Positives = 52/109 (47%), Gaps = 11/109 (10%)

Query: 420 TPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEE-E-----EEEEEEATDS 473
           TP A    GEG +G            E + E  EES+ EEE E E     EEE E+ +D 
Sbjct: 68  TPPAD---GEG-AGKEEAEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDE 123

Query: 474 EEEEDL-EQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLE 521
           E EED  E+M++ QE + EED +EE  +  +G+    S      E   E
Sbjct: 124 ESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPEIEMEAE 172



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 12/94 (12%)

Query: 442 ASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDE-EEDEEEEAAA 500
           A + E + + ++E + E E  EE E EE ++SEEE + E+  E + D+E EED EEE   
Sbjct: 76  AGKEEAEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMED 135

Query: 501 GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQ 534
            ++ +         + E N E G+  S + GE +
Sbjct: 136 EQESE---------AEEDNQEEGE--SEAEGETE 158



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 32/108 (29%), Positives = 54/108 (50%), Gaps = 6/108 (5%)

Query: 399 EEGERKKRRAR-LQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDE 457
           EE E K  + R ++  +   +++ E S    E  +   S+     S  E++++ +EE ++
Sbjct: 79  EEAEVKVEQEREIESEAGEESESEEESESEEESETEEESE---DESDEESEEDSEEEMED 135

Query: 458 EEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGD 505
           E+E E EE+ +E  +SE E + E   E + D E E E E  A  K  D
Sbjct: 136 EQESEAEEDNQEEGESEAEGETE--AESEFDPEIEMEAERVAKRKCPD 181



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 28/106 (26%), Positives = 49/106 (46%), Gaps = 3/106 (2%)

Query: 443 SRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGK 502
           S+A T   D E + +EE E + E+E E    E E   E   E + + EEE E EE +  +
Sbjct: 64  SQAWTPPADGEGAGKEEAEVKVEQEREI---ESEAGEESESEEESESEEESETEEESEDE 120

Query: 503 DGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE 548
             ++S   S +   ++     ++ ++  GE + +G   + S    E
Sbjct: 121 SDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPE 166


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.127    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,297,828
Number of Sequences: 37866
Number of extensions: 1949065
Number of successful extensions: 76700
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1223
Number of HSP's successfully gapped in prelim test: 1031
Number of HSP's that attempted gapping in prelim test: 19252
Number of HSP's gapped (non-prelim): 19298
length of query: 752
length of database: 18,247,518
effective HSP length: 110
effective length of query: 642
effective length of database: 14,082,258
effective search space: 9040809636
effective search space used: 9040809636
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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