BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|215422366 death-domain associated protein isoform b [Homo sapiens] (752 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|215422366 death-domain associated protein isoform b [Homo sap... 1492 0.0 gi|4503257 death-domain associated protein isoform a [Homo sapiens] 1457 0.0 gi|215422388 death-domain associated protein isoform a [Homo sap... 1457 0.0 gi|60498973 myelin transcription factor 1-like [Homo sapiens] 79 2e-14 gi|17975763 myelin transcription factor 1 [Homo sapiens] 75 2e-13 gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 73 8e-13 gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] 68 4e-11 gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens] 67 8e-11 gi|4505999 protein phosphatase 1G [Homo sapiens] 66 1e-10 gi|29826282 protein phosphatase 1G [Homo sapiens] 66 1e-10 gi|21735569 claspin [Homo sapiens] 64 5e-10 gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] 64 5e-10 gi|55956788 nucleolin [Homo sapiens] 63 9e-10 gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 63 1e-09 gi|58761548 tau tubulin kinase 1 [Homo sapiens] 62 1e-09 gi|218505694 potassium channel tetramerisation domain containing... 62 1e-09 gi|210032580 SET domain containing 1B [Homo sapiens] 62 1e-09 gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 62 2e-09 gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 62 2e-09 gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 62 2e-09 gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 62 2e-09 gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 62 2e-09 gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 62 2e-09 gi|115529449 upstream binding transcription factor, RNA polymera... 62 3e-09 gi|115529451 upstream binding transcription factor, RNA polymera... 62 3e-09 gi|7657671 upstream binding transcription factor, RNA polymerase... 62 3e-09 gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 61 3e-09 gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 61 3e-09 gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 61 4e-09 gi|21361639 DIPB protein [Homo sapiens] 60 6e-09 >gi|215422366 death-domain associated protein isoform b [Homo sapiens] Length = 752 Score = 1492 bits (3863), Expect = 0.0 Identities = 752/752 (100%), Positives = 752/752 (100%) Query: 1 MRGSENCGEGRLERRFLSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGAR 60 MRGSENCGEGRLERRFLSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGAR Sbjct: 1 MRGSENCGEGRLERRFLSIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGAR 60 Query: 61 GSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNI 120 GSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNI Sbjct: 61 GSSSSGGKKCYKLENEKLFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNI 120 Query: 121 LSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDP 180 LSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDP Sbjct: 121 LSRVLSRARSRPAKLYVYINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDP 180 Query: 181 TNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARL 240 TNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARL Sbjct: 181 TNAENTASQSPRTRGSRRQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARL 240 Query: 241 KRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGD 300 KRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGD Sbjct: 241 KRKLIRLFGRLCELKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGD 300 Query: 301 VLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 360 VLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV Sbjct: 301 VLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 360 Query: 361 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADT 420 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADT Sbjct: 361 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADT 420 Query: 421 PEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLE 480 PEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLE Sbjct: 421 PEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLE 480 Query: 481 QMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIV 540 QMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIV Sbjct: 481 QMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIV 540 Query: 541 SPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISS 600 SPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISS Sbjct: 541 SPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISS 600 Query: 601 SRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSY 660 SRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSY Sbjct: 601 SRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSY 660 Query: 661 VERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQ 720 VERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQ Sbjct: 661 VERQRSVHEKNGKKICTLPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQ 720 Query: 721 TPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD 752 TPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD Sbjct: 721 TPHSQPPRPGTCKTSVATQCDPEEIIVLSDSD 752 >gi|4503257 death-domain associated protein isoform a [Homo sapiens] Length = 740 Score = 1457 bits (3772), Expect = 0.0 Identities = 735/735 (100%), Positives = 735/735 (100%) Query: 18 SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK 77 SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK Sbjct: 6 SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK 65 Query: 78 LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV 137 LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV Sbjct: 66 LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV 125 Query: 138 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR 197 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR Sbjct: 126 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR 185 Query: 198 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC 257 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC Sbjct: 186 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC 245 Query: 258 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP 317 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP Sbjct: 246 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP 305 Query: 318 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR 377 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR Sbjct: 306 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR 365 Query: 378 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ 437 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ Sbjct: 366 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ 425 Query: 438 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE 497 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE Sbjct: 426 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE 485 Query: 498 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 557 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA Sbjct: 486 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 545 Query: 558 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 617 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA Sbjct: 546 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 605 Query: 618 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT 677 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT Sbjct: 606 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT 665 Query: 678 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA 737 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA Sbjct: 666 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA 725 Query: 738 TQCDPEEIIVLSDSD 752 TQCDPEEIIVLSDSD Sbjct: 726 TQCDPEEIIVLSDSD 740 >gi|215422388 death-domain associated protein isoform a [Homo sapiens] Length = 740 Score = 1457 bits (3772), Expect = 0.0 Identities = 735/735 (100%), Positives = 735/735 (100%) Query: 18 SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK 77 SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK Sbjct: 6 SIIVLDDDDEDEAAAQPGPSHPLPNAASPGAEAPSSSEPHGARGSSSSGGKKCYKLENEK 65 Query: 78 LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV 137 LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV Sbjct: 66 LFEEFLELCKMQTADHPEVVPFLYNRQQRAHSLFLASAEFCNILSRVLSRARSRPAKLYV 125 Query: 138 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR 197 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR Sbjct: 126 YINELCTVLKAHSAKKKLNLAPAATTSNEPSGNNPPTHLSLDPTNAENTASQSPRTRGSR 185 Query: 198 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC 257 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC Sbjct: 186 RQIQRLEQLLALYVAEIRRLQEKELDLSELDDPDSAYLQEARLKRKLIRLFGRLCELKDC 245 Query: 258 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP 317 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP Sbjct: 246 SSLTGRVIEQRIPYRGTRYPEVNRRIERLINKPGPDTFPDYGDVLRAVEKAAARHSLGLP 305 Query: 318 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR 377 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR Sbjct: 306 RQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENR 365 Query: 378 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ 437 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ Sbjct: 366 SLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQ 425 Query: 438 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE 497 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE Sbjct: 426 GCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEE 485 Query: 498 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 557 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA Sbjct: 486 AAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDA 545 Query: 558 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 617 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA Sbjct: 546 ESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 605 Query: 618 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT 677 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT Sbjct: 606 GMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKICT 665 Query: 678 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA 737 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA Sbjct: 666 LPSPPSPLASLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTSVA 725 Query: 738 TQCDPEEIIVLSDSD 752 TQCDPEEIIVLSDSD Sbjct: 726 TQCDPEEIIVLSDSD 740 >gi|60498973 myelin transcription factor 1-like [Homo sapiens] Length = 1184 Score = 79.0 bits (193), Expect = 2e-14 Identities = 76/295 (25%), Positives = 131/295 (44%), Gaps = 34/295 (11%) Query: 388 ISKYAMLQDKSEEGERKKRR---ARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASR 444 ++K QDK + KR+ + +S D + + D E + Sbjct: 57 LAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDE 116 Query: 445 AETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDG 504 +DE+DEE D EEEEE EEE+E+ D E+ ED+E +E +E++EEE+EEEE Sbjct: 117 PGDEDEEDEEGDREEEEEIEEEDED--DDEDGEDVEDEEEEEEEEEEEEEEEE------- 167 Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSS---IDAESNG 561 + + N + ++ ++ ++ E N +V+ SLL+ +A + ES Sbjct: 168 --NEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEM 225 Query: 562 EQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVS 621 +LE++S ++ + E L LD S V + S K +L G G+V Sbjct: 226 NSNTSNSLEDDSDKNENLGRKSE-LSLDLDSDVVRETVDSLK--------LLAQGHGVVL 276 Query: 622 STSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKKIC 676 S + N N+ DS + SR P+ N +E+ + E++ +++C Sbjct: 277 SENMN----DRNYADSMSQ-QDSRNMNYVMLGKPMNNGLMEK---MVEESDEEVC 323 >gi|17975763 myelin transcription factor 1 [Homo sapiens] Length = 1121 Score = 75.1 bits (183), Expect = 2e-13 Identities = 44/108 (40%), Positives = 63/108 (58%), Gaps = 12/108 (11%) Query: 398 SEEGER------KKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDED 451 SEEGE+ + ++ T+ S D SL+ +G S +E+ Sbjct: 207 SEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILS------HEEE 260 Query: 452 DEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499 DEE +EEEEEEEE+EEEE + EEEE+ E+ +E +E++EEE+EEEEAA Sbjct: 261 DEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAA 308 Score = 40.0 bits (92), Expect = 0.008 Identities = 38/166 (22%), Positives = 72/166 (43%), Gaps = 12/166 (7%) Query: 427 SGEGPSGMASQGCPSASRAETDDEDDEE---SDEEEEEEEEEEEEEATDSEEEEDLEQMQ 483 S EG G+ Q + E E ++ E+ EE +++ S EEED E+ + Sbjct: 207 SEEGEKGLFIQPEDAEEVVEVTTERSQDLCPQSLEDAASEESSKQKGILSHEEED-EEEE 265 Query: 484 EGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGK-------QISRSSGEQQNK 536 E +E++EE++EEEE ++ ++ + E+ E + Q S Q Sbjct: 266 EEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAAPDVIFQEDTSHTSAQKA 325 Query: 537 GRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELE 582 + P S +P ++ S+ ++ E+ T +S V+ E++ Sbjct: 326 PELRGPESPSPKPEYSVIVEVRSDDDKDED-THSRKSTVTDESEMQ 370 Score = 39.7 bits (91), Expect = 0.010 Identities = 29/135 (21%), Positives = 55/135 (40%), Gaps = 19/135 (14%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 +S E + ++ +G SH + E + E + E ++E++EE + Sbjct: 238 QSLEDAASEESSKQKGILSHEEEDEEEEEEEEEEEEDEEEEEEEEEEEEEEEEEEEEEEE 297 Query: 457 EEEEEEEEE--------EEEEATDSEEEEDLEQMQEGQ-----------EDDEEEDEEEE 497 EEEEEEEEE E+ T +++ +L + D+++DE+ Sbjct: 298 EEEEEEEEEAAPDVIFQEDTSHTSAQKAPELRGPESPSPKPEYSVIVEVRSDDDKDEDTH 357 Query: 498 AAAGKDGDKSPMSSL 512 + D+S M + Sbjct: 358 SRKSTVTDESEMQDM 372 Score = 35.8 bits (81), Expect = 0.15 Identities = 30/103 (29%), Positives = 43/103 (41%), Gaps = 10/103 (9%) Query: 396 DKSEEGERKKRRARLQGTSSHSAD---TPEASLDSGEGPSGMASQGCPSASRAETDDEDD 452 D S RK+ A +S S+ +P+AS + +S P +S+A DE D Sbjct: 670 DLSMHKHRKRENAFPSSSSCSSSPGVKSPDASQRHSSTSAPSSSMTSPQSSQASRQDEWD 729 Query: 453 EESD-------EEEEEEEEEEEEEATDSEEEEDLEQMQEGQED 488 D EEE EE E + S E +D E +E E+ Sbjct: 730 RPLDYTKPSRLREEEPEESEPAAHSFASSEADDQEVSEENFEE 772 >gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo sapiens] Length = 1130 Score = 73.2 bits (178), Expect = 8e-13 Identities = 69/240 (28%), Positives = 96/240 (40%), Gaps = 65/240 (27%) Query: 431 PSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG----- 485 P G G P A + + SDEEEEEEEEEEEEE + EEEED E+ +E Sbjct: 862 PEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYF 921 Query: 486 ---------------------QEDDEEEDEEEE-----------AAAGKDGDKS------ 507 +E++EEEDEEEE AG + ++ Sbjct: 922 EEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPT 981 Query: 508 -------PMSSLQISNEKNLEPGKQIS-RSSGEQQNKGRIVSPSLLSEEPLAPSSIDAES 559 P S ++ E EPG + G ++ +G +P+L E PS + E Sbjct: 982 LPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPE--ALPSQGEVER 1039 Query: 560 NGEQ------PEELTLEEESPVSQLFELEIE------ALPLDTPSSVETDISSSRKQSEE 607 GE P+EL EE S L E E E P +TP+ E + + + +E Sbjct: 1040 EGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQE 1099 Score = 32.7 bits (73), Expect = 1.3 Identities = 32/122 (26%), Positives = 53/122 (43%), Gaps = 9/122 (7%) Query: 393 MLQDKSEEGERKKRRARLQGTSSHSADTPEASLD-SGEGPS-GMASQGC----PSASRAE 446 +L + E G ++R A T + A + ++ GE P+ G Q PSA Sbjct: 1005 LLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTL 1064 Query: 447 TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 506 ++E ++ SD+ + E EEE E E + E +QE ++DD + D +K Sbjct: 1065 LEEETEDGSDKVQPPPETPAEEE---METETEAEALQEKEQDDTAAMLADFIDCPPDDEK 1121 Query: 507 SP 508 P Sbjct: 1122 PP 1123 >gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] Length = 709 Score = 67.8 bits (164), Expect = 4e-11 Identities = 51/177 (28%), Positives = 81/177 (45%), Gaps = 15/177 (8%) Query: 402 ERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEE 461 E +R +R +S ++ E D G SG + + + E E+D E DEE EE Sbjct: 158 EVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEE 217 Query: 462 EEEEEEEEATDSEEEEDLEQMQEGQEDDEEE----DEEEEAAAGKDGDKSPMSSLQISNE 517 + EE+EE D EEEE+ E+ +E +E++EEE DE ++ G D D +S S Sbjct: 218 DAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSES 277 Query: 518 KNLEPGKQISRSSGE-------QQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEEL 567 + G S S + ++ + R +SP + S +ES +Q +L Sbjct: 278 VSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVFDRS----GSSASESYADQTSKL 330 Score = 42.4 bits (98), Expect = 0.002 Identities = 45/207 (21%), Positives = 83/207 (40%), Gaps = 31/207 (14%) Query: 397 KSEEGERKKRRARLQG------TSSHSADT----PEASLDSGEGPSGMASQGCPS----- 441 K+EE +R +R RL +SS S + PE + P A P Sbjct: 96 KNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERI 155 Query: 442 -------ASRAETDDEDDEESDEEEEEEE------EEEEEEATDSEEE---EDLEQMQEG 485 ASR+ +++ S+E + E +E+ T++EEE ED+E+ +E Sbjct: 156 GLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEV 215 Query: 486 QEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLL 545 +ED EE++E +E ++ ++ + E+ E ++ + G + S S Sbjct: 216 EEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGS 275 Query: 546 SEEPLAPSSIDAESNGEQPEELTLEEE 572 S+ + S + +E E + Sbjct: 276 ESVSFTDGSVRSGSGTDGSDEKKKERK 302 >gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens] Length = 727 Score = 66.6 bits (161), Expect = 8e-11 Identities = 46/152 (30%), Positives = 72/152 (47%), Gaps = 11/152 (7%) Query: 402 ERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEE 461 E +R +R +S ++ E D G SG + + + E E+D E DEE EE Sbjct: 158 EVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEVEE 217 Query: 462 EEEEEEEEATDSEEEEDLEQMQEGQEDDEEE----DEEEEAAAGKDGDKSPMSSLQISNE 517 + EE+EE D EEEE+ E+ +E +E++EEE DE ++ G D D +S S Sbjct: 218 DAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGSES 277 Query: 518 KNLEPGKQISRSSGE-------QQNKGRIVSP 542 + G S S + ++ + R +SP Sbjct: 278 VSFTDGSVRSGSGTDGSDEKKKERKRARGISP 309 Score = 42.4 bits (98), Expect = 0.002 Identities = 45/207 (21%), Positives = 83/207 (40%), Gaps = 31/207 (14%) Query: 397 KSEEGERKKRRARLQG------TSSHSADT----PEASLDSGEGPSGMASQGCPS----- 441 K+EE +R +R RL +SS S + PE + P A P Sbjct: 96 KNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPTPDGSERI 155 Query: 442 -------ASRAETDDEDDEESDEEEEEEE------EEEEEEATDSEEE---EDLEQMQEG 485 ASR+ +++ S+E + E +E+ T++EEE ED+E+ +E Sbjct: 156 GLEVDRRASRSSQSSKEEVNSEEYGSDHETGSSGSSDEQGNNTENEEEGVEEDVEEDEEV 215 Query: 486 QEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLL 545 +ED EE++E +E ++ ++ + E+ E ++ + G + S S Sbjct: 216 EEDAEEDEEVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTRSEASDSGS 275 Query: 546 SEEPLAPSSIDAESNGEQPEELTLEEE 572 S+ + S + +E E + Sbjct: 276 ESVSFTDGSVRSGSGTDGSDEKKKERK 302 >gi|4505999 protein phosphatase 1G [Homo sapiens] Length = 546 Score = 65.9 bits (159), Expect = 1e-10 Identities = 49/130 (37%), Positives = 65/130 (50%), Gaps = 16/130 (12%) Query: 412 GTSSHSADTPEASLDSGEG-PSGMASQGCPSASRA-----------ETDDEDDEESDEEE 459 G SS+S EA G P+G A C SAS +++DE DE +EEE Sbjct: 213 GFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEE 272 Query: 460 EEEEEEEEEEATDSEE---EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516 + EE EEE+ SEE EED + +E +EDDE E+EEE G +G + P S + Sbjct: 273 DSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDE-EEEEEMMVPGMEGKEEPGSDSGTTA 331 Query: 517 EKNLEPGKQI 526 L GKQ+ Sbjct: 332 VVALIRGKQL 341 Score = 35.4 bits (80), Expect = 0.20 Identities = 19/81 (23%), Positives = 39/81 (48%) Query: 398 SEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDE 457 S ++ R A+ + ++ EA + + + S+ AE ++++D+ + Sbjct: 242 SSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEA 301 Query: 458 EEEEEEEEEEEEATDSEEEED 478 EE++EEEEEE E +E+ Sbjct: 302 EEDDEEEEEEMMVPGMEGKEE 322 Score = 30.4 bits (67), Expect = 6.3 Identities = 46/244 (18%), Positives = 88/244 (36%), Gaps = 7/244 (2%) Query: 320 QLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSL 379 +LQ +DAF + +L + + T+D A D V Sbjct: 89 KLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEE 148 Query: 380 AMSRLDEVISKYAMLQDK----SEEGERKKRRARLQGTSSHSA--DTPEASLDSGEGPSG 433 A ++E++++Y K S+ G QG + + D+ + GP+ Sbjct: 149 ATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTA 208 Query: 434 MASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEED 493 A G S S T+ E E + + ++ +++ +E + Sbjct: 209 KAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAE 268 Query: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPS 553 EEEE + ++ SS + NE++ E + + E++ + +V EEP + S Sbjct: 269 EEEEDSEECSEEEDGYSSEEAENEED-EDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDS 327 Query: 554 SIDA 557 A Sbjct: 328 GTTA 331 >gi|29826282 protein phosphatase 1G [Homo sapiens] Length = 546 Score = 65.9 bits (159), Expect = 1e-10 Identities = 49/130 (37%), Positives = 65/130 (50%), Gaps = 16/130 (12%) Query: 412 GTSSHSADTPEASLDSGEG-PSGMASQGCPSASRA-----------ETDDEDDEESDEEE 459 G SS+S EA G P+G A C SAS +++DE DE +EEE Sbjct: 213 GFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAEEEEE 272 Query: 460 EEEEEEEEEEATDSEE---EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516 + EE EEE+ SEE EED + +E +EDDE E+EEE G +G + P S + Sbjct: 273 DSEECSEEEDGYSSEEAENEEDEDDTEEAEEDDE-EEEEEMMVPGMEGKEEPGSDSGTTA 331 Query: 517 EKNLEPGKQI 526 L GKQ+ Sbjct: 332 VVALIRGKQL 341 Score = 35.4 bits (80), Expect = 0.20 Identities = 19/81 (23%), Positives = 39/81 (48%) Query: 398 SEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDE 457 S ++ R A+ + ++ EA + + + S+ AE ++++D+ + Sbjct: 242 SSASDKLPRVAKSKFFEDSEDESDEAEEEEEDSEECSEEEDGYSSEEAENEEDEDDTEEA 301 Query: 458 EEEEEEEEEEEEATDSEEEED 478 EE++EEEEEE E +E+ Sbjct: 302 EEDDEEEEEEMMVPGMEGKEE 322 Score = 30.4 bits (67), Expect = 6.3 Identities = 46/244 (18%), Positives = 88/244 (36%), Gaps = 7/244 (2%) Query: 320 QLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGVDPALSDPVLARRLRENRSL 379 +LQ +DAF + +L + + T+D A D V Sbjct: 89 KLQKALEDAFLAIDAKLTTEEVIKELAQIAGRPTEDEDEKEKVADEDDVDNEEAALLHEE 148 Query: 380 AMSRLDEVISKYAMLQDK----SEEGERKKRRARLQGTSSHSA--DTPEASLDSGEGPSG 433 A ++E++++Y K S+ G QG + + D+ + GP+ Sbjct: 149 ATMTIEELLTRYGQNCHKGPPHSKSGGGTGEEPGSQGLNGEAGPEDSTRETPSQENGPTA 208 Query: 434 MASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEED 493 A G S S T+ E E + + ++ +++ +E + Sbjct: 209 KAYTGFSSNSERGTEAGQVGEPGIPTGEAGPSCSSASDKLPRVAKSKFFEDSEDESDEAE 268 Query: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPS 553 EEEE + ++ SS + NE++ E + + E++ + +V EEP + S Sbjct: 269 EEEEDSEECSEEEDGYSSEEAENEED-EDDTEEAEEDDEEEEEEMMVPGMEGKEEPGSDS 327 Query: 554 SIDA 557 A Sbjct: 328 GTTA 331 >gi|21735569 claspin [Homo sapiens] Length = 1339 Score = 63.9 bits (154), Expect = 5e-10 Identities = 60/207 (28%), Positives = 96/207 (46%), Gaps = 28/207 (13%) Query: 448 DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507 D+ED E +EEEEEE +E EE D EE+ + E+ +E E++EE++EEEE ++ + Sbjct: 623 DNEDGFEEEEEEEEEMTDESEE--DGEEKVEKEEKEEELEEEEEKEEEEEEEGNQETAEF 680 Query: 508 PMSSLQISNEKNLEPGKQISRSSGE-QQNKGRIVSPSLLSEE----------------PL 550 +SS +I + E K+ + S E + G + P LS + P Sbjct: 681 LLSSEEIETKDEKEMDKENNDGSSEIGKAVGFLSVPKSLSSDSTLLLFKDSSSKMGYFPT 740 Query: 551 APSSIDAESNGEQPEEL-------TLEEESPVSQLFELEIEALPLDTPSSVETDISSSRK 603 S E++G+QP +L L +ES + FEL +P P + +T +S Sbjct: 741 EEKSETDENSGKQPSKLDEDDSCSLLTKESSHNSSFELIGSTIPSYQPCNRQTGRGTSFF 800 Query: 604 QSEEPFTTVLEN--GAGMVSSTSFNGG 628 + F + A +VSS S + G Sbjct: 801 PTAGGFRSPSPGLFRASLVSSASKSSG 827 Score = 35.8 bits (81), Expect = 0.15 Identities = 31/120 (25%), Positives = 54/120 (45%), Gaps = 9/120 (7%) Query: 414 SSHSADTPEAS-LDSGEGPSGMAS---QGCPSASRAETDDEDDEESDEEEEEEEEEEEEE 469 +S A TP +S L+ E S M + S + D+++E+ +EE + + Sbjct: 949 TSQDASTPASSELNKQEKESSMGDPMEEALALCSGSFPTDKEEEDEEEEFGDFRLVSNDN 1008 Query: 470 ATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRS 529 DS+E+E + + +D E+D+EEE +S Q+ K LE ++S S Sbjct: 1009 EFDSDEDEHSDSGNDLALEDHEDDDEEELL-----KRSEKLKRQMRLRKYLEDEAEVSGS 1063 Score = 35.0 bits (79), Expect = 0.26 Identities = 61/268 (22%), Positives = 99/268 (36%), Gaps = 39/268 (14%) Query: 445 AETDDEDDEESDEEEEEEEEEEEEEATDS--EEEEDLE------QMQEGQEDDEEEDE-- 494 AE D DE + EE +E EE+ D +E+L+ M+ +DD+ + Sbjct: 1058 AEVSGSDVGSEDEYDGEEIDEYEEDVIDEVLPSDEELQSQIKKIHMKTMLDDDKRQLRLY 1117 Query: 495 EEEAAAGKDGDKSPMSSLQISNEKNLEPGKQIS---RSSGEQQNKGRIVSPSLLSEEPLA 551 +E A D ++ KN++ Q+ R S + Q + ++ SE Sbjct: 1118 QERYLADGDLHSDGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDE----SEARWR 1173 Query: 552 PSSIDAES---NGEQPEELTLEEESPVSQ-----LFELEIEALPLDTPSSVETDISSSRK 603 I+ E + Q ++T EEE + + + ++ A L +S I S+ Sbjct: 1174 KERIEREQWLRDMAQQGKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKS 1233 Query: 604 QSEEPFTTVLENGAGMVSSTSF----------NGGVSPHNWGDSGPPCKKSRKEKKQTGS 653 PF + A V + S +S HN S P + SR T S Sbjct: 1234 LLRNPFEAIRPGSAQQVKTGSLLNQPKAVLQKLAALSDHN--PSAP--RNSRNFVFHTLS 1289 Query: 654 GPLGNSYVERQRSVHEKNGKKICTLPSP 681 + E +S +K G T PSP Sbjct: 1290 PVKAEAAKESSKSQVKKRGPSFMTSPSP 1317 Score = 33.1 bits (74), Expect = 0.97 Identities = 36/127 (28%), Positives = 57/127 (44%), Gaps = 16/127 (12%) Query: 414 SSHSADTPEASLDSGEGPS---GMASQGCPS----ASRAETDDEDDEESDEEEEEEEEEE 466 S AD+P DSG+G G S+G S+ + + ++SD E E+ Sbjct: 20 SQEEADSPS---DSGQGSYETIGPLSEGDSDEEIFVSKKLKNRKVLQDSDSETEDTNASP 76 Query: 467 EEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM--SSLQISNEKNLEPGK 524 E+ DS EEE+ E + G+ + + A D D+S M S Q + E ++P Sbjct: 77 EKTTYDSAEEENKENLYAGKNTKIKRIYKTVA----DSDESYMEKSLYQENLEAQVKPCL 132 Query: 525 QISRSSG 531 ++S SG Sbjct: 133 ELSLQSG 139 Score = 32.7 bits (73), Expect = 1.3 Identities = 47/198 (23%), Positives = 80/198 (40%), Gaps = 25/198 (12%) Query: 429 EGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEE---EATDSEEEEDLEQM-QE 484 +GP M + A D +SD+++ EE+ +E E E E+ L M Q+ Sbjct: 1130 DGPGRMRKFRWKNIDDASQMDLFHRDSDDDQTEEQLDESEARWRKERIEREQWLRDMAQQ 1189 Query: 485 GQEDDEEEDEEEE---------AAAGKDGDKSPMSSLQISNEKNL--EPGKQISRSSGEQ 533 G+ EEE+E E K K+ + I K+L P + I S +Q Sbjct: 1190 GKITAEEEEEIGEDSQFMILAKKVTAKALQKNASRPMVIQESKSLLRNPFEAIRPGSAQQ 1249 Query: 534 QNKGRIVS---------PSLLSEEPLAP-SSIDAESNGEQPEELTLEEESPVSQLFELEI 583 G +++ +L P AP +S + + P + +ES SQ+ + Sbjct: 1250 VKTGSLLNQPKAVLQKLAALSDHNPSAPRNSRNFVFHTLSPVKAEAAKESSKSQVKKRGP 1309 Query: 584 EALPLDTPSSVETDISSS 601 + +P ++TD S+S Sbjct: 1310 SFMTSPSPKHLKTDDSTS 1327 >gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] Length = 587 Score = 63.9 bits (154), Expect = 5e-10 Identities = 37/81 (45%), Positives = 46/81 (56%), Gaps = 11/81 (13%) Query: 447 TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDK 506 +DDED+EE +E EEEEEE EEEE D EEEE +EEE+EEEE G+K Sbjct: 358 SDDEDEEEEEEGEEEEEEAEEEEEEDEEEEE-----------EEEEEEEEEPQQRGQGEK 406 Query: 507 SPMSSLQISNEKNLEPGKQIS 527 S S +I + EP +S Sbjct: 407 SATPSRKILDPNTGEPAPVLS 427 Score = 31.6 bits (70), Expect = 2.8 Identities = 54/241 (22%), Positives = 92/241 (38%), Gaps = 46/241 (19%) Query: 254 LKDCSSLTGRVIEQRIPYRGTRYPEVNRRIERLINKP-------GPDTFPDYGDVLRAVE 306 L + + G + E +P G +P + + P +TF + G V A Sbjct: 200 LAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAET 259 Query: 307 KAAARH----SLG--LPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYRPGV 360 R + G L R + + DA R +L+E L+L + C + D V Sbjct: 260 LKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLKE---LNLSF---CEIKRDAALAV 313 Query: 361 DPALSDPVLARRLRENRSL----AMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSH 416 A++D +L N + +L EV+ + M + +S Sbjct: 314 AEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKV----------------LASL 357 Query: 417 SADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEE--EEEEEATDSE 474 S D E + GE A + E ++E++EE +EEEEE ++ + E+ AT S Sbjct: 358 SDDEDEEEEEEGEEEEEEAEE-----EEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSR 412 Query: 475 E 475 + Sbjct: 413 K 413 Score = 30.0 bits (66), Expect = 8.2 Identities = 40/169 (23%), Positives = 68/169 (40%), Gaps = 18/169 (10%) Query: 441 SASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAA 500 + + A D + E+ D EE E+ + E ++ ++ DDE+E+EEEE Sbjct: 312 AVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEE--- 368 Query: 501 GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESN 560 G++ + + E E ++ E Q +G+ + S + L P++ Sbjct: 369 ---GEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNT------ 419 Query: 561 GEQPEELTLEEESPVSQL--FELEIEALPLDTPSSV----ETDISSSRK 603 GE L+ + VS F + L L SSV +TD S K Sbjct: 420 GEPAPVLSSPPPADVSTFLAFPSPEKLLRLGPKSSVLIAQQTDTSDPEK 468 >gi|55956788 nucleolin [Homo sapiens] Length = 710 Score = 63.2 bits (152), Expect = 9e-10 Identities = 63/261 (24%), Positives = 109/261 (41%), Gaps = 63/261 (24%) Query: 408 ARLQGTSSHSADTPEASLDSGEGPSGMA--SQGCPSASRAETDDEDDEESDEEEEEEEEE 465 A+ T TP +L + G G A ++G + A+ +D D+EE D+ EE+EE++ Sbjct: 101 AKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDD 160 Query: 466 EEEE------------------ATDSEEEEDLEQMQEGQEDDEEEDEEEEA-----AAGK 502 E+E+ A++ E++ED ++ E +DDEE+D EEEA A GK Sbjct: 161 EDEDEDEDEIEPAAMKAAAAAPASEDEDDED-DEDDEDDDDDEEDDSEEEAMETTPAKGK 219 Query: 503 DGDK-SPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNG 561 K P+ + ++ +++ E + ++ ++ D E + Sbjct: 220 KAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDE-----------------DDDDEDDE 262 Query: 562 EQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVS 621 E+ EE EEE PV + P + +++ + E V G Sbjct: 263 EEEEE---EEEEPVK------------EAPGKRKKEMAKQKAAPEAKKQKV----EGTEP 303 Query: 622 STSFNGGVSPHNWGDSGPPCK 642 +T+FN V N+ S P K Sbjct: 304 TTAFNLFVGNLNFNKSAPELK 324 Score = 51.2 bits (121), Expect = 3e-06 Identities = 33/164 (20%), Positives = 77/164 (46%), Gaps = 28/164 (17%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 K+ + +K+ + S + + D E A+ +A+ A D++D+++ D Sbjct: 135 KNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDED 194 Query: 457 EEEEEEEEEE--EEEATDS------------------------EEEEDLEQMQEGQEDDE 490 +E+++++EE+ EEEA ++ EEE+D ++ + EDDE Sbjct: 195 DEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDE 254 Query: 491 EEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQ 534 ++D+E++ ++ ++ P+ + ++ E KQ + ++Q Sbjct: 255 DDDDEDDEEEEEEEEEEPVK--EAPGKRKKEMAKQKAAPEAKKQ 296 Score = 50.4 bits (119), Expect = 6e-06 Identities = 35/144 (24%), Positives = 60/144 (41%), Gaps = 40/144 (27%) Query: 400 EGERKKRRARLQGTSSHSADTPEASLDSGEG---------PSGMASQGCPSASRAETDDE 450 +G + + A+ + + D E + E P+ M + AS E D++ Sbjct: 132 KGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDED 191 Query: 451 D----DEESDEEEEEEE---------------------------EEEEEEATDSEEEEDL 479 D D++ DEE++ EE E+EEE+ D ++++D Sbjct: 192 DEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDE 251 Query: 480 EQMQEGQEDDEEEDEEEEAAAGKD 503 + + EDDEEE+EEEE K+ Sbjct: 252 DDEDDDDEDDEEEEEEEEEEPVKE 275 Score = 45.4 bits (106), Expect = 2e-04 Identities = 25/122 (20%), Positives = 59/122 (48%), Gaps = 3/122 (2%) Query: 419 DTPEASLDSGEGPSGMASQGCPSASRAETDDED---DEESDEEEEEEEEEEEEEATDSEE 475 D+ E ++++ A++ P ++ +DED D+E ++++++E++E++++ D EE Sbjct: 205 DSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEE 264 Query: 476 EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQN 535 EE+ E+ + + + E + A + K + + + NL G S + Sbjct: 265 EEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELK 324 Query: 536 KG 537 G Sbjct: 325 TG 326 >gi|84043963 eukaryotic translation initiation factor 5B [Homo sapiens] Length = 1220 Score = 62.8 bits (151), Expect = 1e-09 Identities = 44/120 (36%), Positives = 60/120 (50%), Gaps = 5/120 (4%) Query: 399 EEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEE 458 E+G +K DT +A LD E MAS + +E+ EE Sbjct: 477 EQGVPEKEETPPPVEPEEEEDTEDAGLDDWEA---MASDEETEKVEGNKVHIEVKENPEE 533 Query: 459 EEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDE-EEEAAAGKDGDKSPMSSLQISNE 517 EEEEEEEEEE+ +SEEEE+ E EG E DEE+++ +E +GK DK P + +E Sbjct: 534 EEEEEEEEEED-EESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSE 592 Score = 48.9 bits (115), Expect = 2e-05 Identities = 65/304 (21%), Positives = 125/304 (41%), Gaps = 55/304 (18%) Query: 361 DPALSDPVLARRLRENRSLAMSRLDEVISKYAMLQDKSE-EGERKKRRARLQGTSSHSAD 419 D + +A++ E + + DE +K L++K E E +K + + + + Sbjct: 220 DASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEE 279 Query: 420 TPEA--SLDSGEGPSGMASQGCPSASRAETDDEDDEESDE------EEEEEEEE------ 465 T ++ ++D+G P+ P+A AE D+E D++ + E+EE+E+E Sbjct: 280 TVKSKVTVDTGVIPASEEKAETPTA--AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPS 337 Query: 466 ---------------EEEEATDSEEEEDLEQMQ--EGQEDDEEEDEEEEAAAGKDGDKSP 508 EEEE EEEE +++++ E + +EE E+E+ K +K Sbjct: 338 KATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKE- 396 Query: 509 MSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSS---------IDAES 559 E+ + GK +++S E + + L ++ PS + + Sbjct: 397 ------RKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKK 450 Query: 560 NGEQPEELTLEEESPVSQLFEL--EIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGA 617 + P++L E VS+ EL +E + P ET ++ E+ L++ Sbjct: 451 RKKIPQQL---ESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWE 507 Query: 618 GMVS 621 M S Sbjct: 508 AMAS 511 Score = 47.4 bits (111), Expect = 5e-05 Identities = 48/189 (25%), Positives = 90/189 (47%), Gaps = 30/189 (15%) Query: 368 VLARRLRENRSLAMSRLD-------EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADT 420 +L + RE R+ A + L EV SK ++ + + ++K+++ Q S +++ Sbjct: 407 LLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSES 466 Query: 421 PE--ASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDS----- 473 E A+++ E + P E +D +D D+ E +EE E+ + Sbjct: 467 MELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIE 526 Query: 474 ------EEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEK------NLE 521 EEEE+ E+ +E +E +EEE+EE E + G +GD+ ++S+EK + + Sbjct: 527 VKENPEEEEEEEEEEEEDEESEEEEEEEGE-SEGSEGDE---EDEKVSDEKDSGKTLDKK 582 Query: 522 PGKQISRSS 530 P K++S S Sbjct: 583 PSKEMSSDS 591 Score = 39.3 bits (90), Expect = 0.014 Identities = 25/91 (27%), Positives = 47/91 (51%), Gaps = 13/91 (14%) Query: 446 ETDDEDDEESDEEEEE------EEEEEEEEATDSE------EEEDLEQMQEGQEDDEEED 493 E ++ED+E +EEEEE E +EE+E+ +D + +++ ++M E D ++D Sbjct: 539 EEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDD 598 Query: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGK 524 +E A D K + ++ + KN+ K Sbjct: 599 RTKEERA-YDKAKRRIEKRRLEHSKNVNTEK 628 Score = 38.1 bits (87), Expect = 0.030 Identities = 55/278 (19%), Positives = 117/278 (42%), Gaps = 46/278 (16%) Query: 447 TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLE--------------QMQEGQEDDEEE 492 T++ ++E + ++++++ ++ ++++ D + E+LE +M G +DD++ Sbjct: 84 TENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDF 143 Query: 493 DEEEEAAAGK-------------DGDKS----PMSSLQISNEKNLEPGKQISRSSGEQQN 535 ++ + A GK D D S S + S E E + + G+++N Sbjct: 144 NKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKN 203 Query: 536 KGRIVSPSLLS--EEPLAPSSID--AESNGEQPEELTLEEESPVSQLFELEIEALPLDTP 591 + P++ S E+ A I A+ E+ E + + ++L +L+ E L+T Sbjct: 204 QKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLK-EKEELETG 262 Query: 592 SSVET-DISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQ 650 ++ S RK EE + + G++ + S +P D KK + +KK+ Sbjct: 263 KKDQSKQKESQRKFEEETVKSKVTVDTGVIPA-SEEKAETPTAAEDDNEGDKKKKDKKKK 321 Query: 651 TGSGPLGNSYVERQRSVHEKNGKKICTLPSPPSPLASL 688 G + ++ +K G T+ + LA L Sbjct: 322 KGE--------KEEKEKEKKKGPSKATVKAMQEALAKL 351 Score = 36.6 bits (83), Expect = 0.088 Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 14/90 (15%) Query: 446 ETDDEDDEESDEEEEEE--------------EEEEEEEATDSEEEEDLEQMQEGQEDDEE 491 E ++E+DEES+EEEEEE +E++ +++ E + + D ++ Sbjct: 538 EEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD 597 Query: 492 EDEEEEAAAGKDGDKSPMSSLQISNEKNLE 521 + +EE A K + L+ S N E Sbjct: 598 DRTKEERAYDKAKRRIEKRRLEHSKNVNTE 627 >gi|58761548 tau tubulin kinase 1 [Homo sapiens] Length = 1321 Score = 62.4 bits (150), Expect = 1e-09 Identities = 56/206 (27%), Positives = 91/206 (44%), Gaps = 29/206 (14%) Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499 P A + + + +EEEEEE+EEEEEE +EEE+ E+ +E +E++EEE+EEEEAA Sbjct: 718 PQVPLAPVQPQANGKEEEEEEEEDEEEEEE----DEEEEEEEEEEEEEEEEEEEEEEEAA 773 Query: 500 AG---------KDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPL 550 A + G S S + P ++ E + + + L EE Sbjct: 774 AAVALGEVLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMADGDLEPEE-- 831 Query: 551 APSSIDAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFT 610 ++ S G+ + E +P + ++ L TP + S+ EP T Sbjct: 832 GSKTLVLVSPGDMKKSPVTAELAP-----DPDLGTLAALTPQHERPQPTGSQLDVSEPGT 886 Query: 611 --TVLEN-------GAGMVSSTSFNG 627 +VL++ GAG+ + T G Sbjct: 887 LSSVLKSEPKPPGPGAGLGAGTVTTG 912 Score = 33.9 bits (76), Expect = 0.57 Identities = 61/270 (22%), Positives = 102/270 (37%), Gaps = 58/270 (21%) Query: 377 RSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMAS 436 RSL R++ S+ D E ++ R L G+ S A + + P+ M S Sbjct: 447 RSLRYRRVNSPESERLSTADGRVELPERRSRMDLPGSPSRQACSSQ--------PAQMLS 498 Query: 437 QGCPSASRAETDDEDDEESDEEEE-----------EEEEEEEEEATDSEEEEDLEQMQEG 485 A R + D S E+E EEE+ + +E ++E +L+ G Sbjct: 499 VDTGHADRQASGRMDVSASVEQEALSNAFRSVPLAEEEDFDSKEWVIIDKETELKDFPPG 558 Query: 486 QE------DDEEEDE--------EEEAAAGKDGDKSPMS-SLQISNEKNLEP------GK 524 E DEE +E EE G + P S+Q E++L+ Sbjct: 559 AEPSTSGTTDEEPEELRPLPEEGEERRRLGAEPTVRPRGRSMQALAEEDLQHLPPQPLPP 618 Query: 525 QISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFEL--- 581 Q+S+ G + + +P S PL +G +P + P Q+F + Sbjct: 619 QLSQGDGRSET-SQPPTPGSPSHSPL--------HSGPRPRRRESDPTGPQRQVFSVAPP 669 Query: 582 -EIEALPLDTPSSV-----ETDISSSRKQS 605 E+ LP P S+ + D+S R+++ Sbjct: 670 FEVNGLPRAVPLSLPYQDFKRDLSDYRERA 699 >gi|218505694 potassium channel tetramerisation domain containing 1 isoform b [Homo sapiens] Length = 865 Score = 62.4 bits (150), Expect = 1e-09 Identities = 51/175 (29%), Positives = 80/175 (45%), Gaps = 11/175 (6%) Query: 412 GTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEAT 471 G++S +A E + + GEG G +G R + +EEEEEEEE+E +E Sbjct: 16 GSASAAAAAAENNGERGEGERGAGGRG-----RRHSRPHYCSAGEEEEEEEEEDEIQEVQ 70 Query: 472 DSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSG 531 + +EE+ E G E+DEEE+EEEE D P S E EP I+ Sbjct: 71 ITGDEEEEEDGGGGLEEDEEEEEEEEMGLDWDEPLEPEDS--AGEELEPEPVHMINMDQS 128 Query: 532 ---EQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPVSQLFELEI 583 E + R+++P P S +D + ++PE L E + ++ + + I Sbjct: 129 AALEPEAPPRLLAPRARGGPPGDGSELDPDVL-QRPERARLSENTRLATRYAVRI 182 >gi|210032580 SET domain containing 1B [Homo sapiens] Length = 1923 Score = 62.4 bits (150), Expect = 1e-09 Identities = 88/383 (22%), Positives = 147/383 (38%), Gaps = 67/383 (17%) Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEA-----------SLDSGEGPSGMASQGCPSA 442 + ++ EE ER++ R + P+ LDSG S S Sbjct: 987 VDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESL---SE 1043 Query: 443 SRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGK 502 + T++E++ E +EEEE++++++ ++ +SE +++ + E E DE + +EEE + Sbjct: 1044 EQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIV 1103 Query: 503 DGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNK--GRIVSPSLLSEEPLAPSSI----- 555 SS + S E + S SS E + + R EE +A S+ Sbjct: 1104 TSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGP 1163 Query: 556 -DAESNGEQP---------EELTLEEESPVSQLFELEIEAL-PLDTPSSVE--------T 596 D E +GE+ + L +EEE ++E EA+ P + PS ++ Sbjct: 1164 EDFEQDGEEAALAPGAPAVDSLGMEEE------VDIETEAVAPEERPSMLDEPPLPVGVE 1217 Query: 597 DISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWGDSGPPCKKSRKEKKQTGSGPL 656 + + SR+ EEP + + GA ++S P ++ PP R + P Sbjct: 1218 EPADSREPPEEP--GLSQEGAMLLSPE------PPAKEVEARPPLSPERAPEHDLEVEPE 1269 Query: 657 GNSYVERQRSVHEKNGKKICTLPSPPSPL-------ASLAPVADSSTRVDSPSH--GLVT 707 + + P PPSP AS V D P H GL Sbjct: 1270 PPMMLPLPLQPPLPPPRP----PRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCG 1325 Query: 708 SSLCIPSPARLSQTPHSQPPRPG 730 S S + TP +PP G Sbjct: 1326 SLAKSQSTETVPATPGGEPPLSG 1348 Score = 43.1 bits (100), Expect = 0.001 Identities = 75/352 (21%), Positives = 118/352 (33%), Gaps = 55/352 (15%) Query: 431 PSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATD------------------ 472 PS + P + + D + S +EE+EE E E D Sbjct: 960 PSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGV 1019 Query: 473 ---------------SEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNE 517 +E+E L + QE E++EE +EEEE D D + +E Sbjct: 1020 RRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEEDDDDDDSDDRDESENDDE 1079 Query: 518 KNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEESPV 575 E ++ S E++ + S + + + S + ES+ E + +EE V Sbjct: 1080 DTALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVV 1139 Query: 576 SQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLENGAGMVSSTSFNGGVSPHNWG 635 ++ E E E + S+ + +Q E L GA V S V Sbjct: 1140 AREEEEEEEEEEMVAEESMASAGPEDFEQDGE--EAALAPGAPAVDSLGMEEEVDI---- 1193 Query: 636 DSGPPCKKSRKEKKQTGSGPLGNSYVERQRSVHEKNGKK----ICTLPSPPS-------P 684 ++ + R P+G R E+ G + P PP+ P Sbjct: 1194 ETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPP 1253 Query: 685 LA-SLAPVADSSTRVDSPSHGLVTSSLCIPSPARLSQTPHSQPPRPGTCKTS 735 L+ AP D + P ++ L P P P S PP P T S Sbjct: 1254 LSPERAPEHDLEVEPEPPM--MLPLPLQPPLPPPRPPRPPSPPPEPETTDAS 1303 >gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo sapiens] Length = 1152 Score = 62.0 bits (149), Expect = 2e-09 Identities = 49/182 (26%), Positives = 78/182 (42%), Gaps = 10/182 (5%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454 + + EEGE ++ +G E + GEG +G E ++E + E Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEG------EGEEEEGEGEGEEEGEGE 894 Query: 455 SDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGD---KSPMSS 511 +EEE E E EEE E EEE + + +EG+E + E +EEE G+DG+ + Sbjct: 895 GEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE 954 Query: 512 LQISNEKNLEPGKQISRSSGEQ-QNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLE 570 + E+ G++ GE+ + +G EE + E GE+ E E Sbjct: 955 WEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGE 1014 Query: 571 EE 572 EE Sbjct: 1015 EE 1016 Score = 60.5 bits (145), Expect = 6e-09 Identities = 43/145 (29%), Positives = 64/145 (44%), Gaps = 5/145 (3%) Query: 397 KSEEGERKKR-RARLQGTSSHSADTPEASLDSGEGPSGMASQGCP----SASRAETDDED 451 + EEGERKK RA + D E + EG +G + + E+ Sbjct: 769 EKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREE 828 Query: 452 DEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511 +EE E EEEE E EEEE EEE + + +EG+E + EE+ EE G++ + Sbjct: 829 EEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGE 888 Query: 512 LQISNEKNLEPGKQISRSSGEQQNK 536 + E E G+ GE + + Sbjct: 889 EEGEGEGEEEEGEGEGEEEGEGEGE 913 Score = 57.4 bits (137), Expect = 5e-08 Identities = 49/182 (26%), Positives = 79/182 (43%), Gaps = 12/182 (6%) Query: 396 DKSEEGERKKRRARLQGTSSHSADTPEAS----LDSGEGPSGMASQGCPSASRAETDDED 451 ++ E+GE+ K R ++ + E D E QG E ++ Sbjct: 672 EEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGG 731 Query: 452 DEESDEEEEEEEEEEEEEATDSEEEEDLE-QMQEGQEDDEEEDEEEEAAAGKDGDKSPMS 510 +EE E EEEE + EEEE + E +E+ E + EG+ + EE + ++E AGK+ +K Sbjct: 732 EEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKE-EKGEEE 790 Query: 511 SLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLE 570 Q E+ G+ GE++ +G V + E + E GE+ E E Sbjct: 791 GDQGEGEEEETEGR------GEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEE 844 Query: 571 EE 572 EE Sbjct: 845 EE 846 Score = 57.0 bits (136), Expect = 6e-08 Identities = 43/150 (28%), Positives = 67/150 (44%), Gaps = 10/150 (6%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454 + + EEGE + +G E + GEG +G E ++E+ E Sbjct: 931 EGEEEEGEGEGEDG--EGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEG 988 Query: 455 SDEEEEEEEE-------EEEEEATDSEEEE-DLEQMQEGQEDDEEEDEEEEAAAGKDGDK 506 EEEE EEE EEE E EEEE ++E EG+E + E +EEE G++ +K Sbjct: 989 EGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREK 1048 Query: 507 SPMSSLQISNEKNLEPGKQISRSSGEQQNK 536 N + E + + +GE++N+ Sbjct: 1049 EGEGEENRRNREEEEEEEGKYQETGEEENE 1078 Score = 52.8 bits (125), Expect = 1e-06 Identities = 53/197 (26%), Positives = 82/197 (41%), Gaps = 29/197 (14%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454 + + EEGE K +G + E + GEG G +G E + E +EE Sbjct: 911 EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG-EGEEEEGEWEGEEEEGEGEGEEE 969 Query: 455 SDEEEEE------------EEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGK 502 + E EE E EEEE E + EEE + E+ EG+ ++EEE E E G+ Sbjct: 970 GEGEGEEGEGEGEEEEGEGEGEEEEGE-EEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 1028 Query: 503 DGDKSPMSSLQISNEKNLEPGKQISR-SSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNG 561 +G+ + E+ E G++ + GE+ + R EE E+ Sbjct: 1029 EGEG------EGEEEEGEEEGEEREKEGEGEENRRNR--------EEEEEEEGKYQETGE 1074 Query: 562 EQPEELTLEEESPVSQL 578 E+ E EE VS++ Sbjct: 1075 EENERQDGEEYKKVSKI 1091 Score = 50.8 bits (120), Expect = 5e-06 Identities = 48/186 (25%), Positives = 78/186 (41%), Gaps = 21/186 (11%) Query: 395 QDKSEEGERKKRRARL-QGTSSHSADTPEASLDSGEGP------SGMASQGCPSASRAET 447 + + EEG+R++ + +G + E + EG +G +G + E Sbjct: 737 EGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEG 796 Query: 448 DDEDDEESDEEEEEEEEEEEEEATDS-----EEEEDLEQMQEGQEDDEEEDE-EEEAAAG 501 ++E+ E EE+EE E E E + EEEE+ E +E E +EEE E EEE G Sbjct: 797 EEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEG 856 Query: 502 KDGDKSPMSSLQISNEKNLEPG-KQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESN 560 K ++ + E+ G ++ GE++ +G EE + E Sbjct: 857 KGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGE-------GEEEEGEGEGEEEGE 909 Query: 561 GEQPEE 566 GE EE Sbjct: 910 GEGEEE 915 Score = 50.1 bits (118), Expect = 8e-06 Identities = 42/163 (25%), Positives = 67/163 (41%), Gaps = 19/163 (11%) Query: 400 EGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEE 459 EGE ++ +G + E + E G + E + E+ E EEE Sbjct: 978 EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEE 1037 Query: 460 EEEEEEEEEEA----------TDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM 509 E EEE EE E + EEEE+ + + G+E++E +D EE K Sbjct: 1038 EGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSK-----IK 1092 Query: 510 SSLQISNEKNLEPGKQISRSSG---EQQNKGRIVSPSLLSEEP 549 S++ K + K ++ + G EQ++K + S LL P Sbjct: 1093 GSVKYGKHKTYQK-KSVTNTQGNGKEQRSKMPVQSKRLLKNGP 1134 Score = 48.5 bits (114), Expect = 2e-05 Identities = 40/184 (21%), Positives = 75/184 (40%), Gaps = 11/184 (5%) Query: 386 EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRA 445 EV A ++E+G + + SS + + + GE G P Sbjct: 635 EVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEK 694 Query: 446 ETDDEDD---EESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGK 502 E ++++ + +E+E++E E+ ++ + E EE E+ E++E + EEEE G+ Sbjct: 695 ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE 754 Query: 503 DGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGE 562 K ++ E+ E G++ ++ KG EE + E GE Sbjct: 755 --GKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEE------ETEGRGE 806 Query: 563 QPEE 566 + EE Sbjct: 807 EKEE 810 Score = 47.8 bits (112), Expect = 4e-05 Identities = 43/182 (23%), Positives = 74/182 (40%), Gaps = 8/182 (4%) Query: 397 KSEEGERKKRRARLQG----TSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDD 452 K +GE ++++ R QG + + E GE G + + + E + Sbjct: 703 KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGE 762 Query: 453 EESDEEEEEEEEEEEEEATDSEE--EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMS 510 E E E+EE E ++EE EE EE+ +Q + +E+ E EE+E +G + Sbjct: 763 EVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEG 822 Query: 511 SLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLE 570 + E+ G++ E++ +G EE + E GE+ E E Sbjct: 823 KGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEE--EGEEGEGEEEGEEGEGEGEE 880 Query: 571 EE 572 EE Sbjct: 881 EE 882 Score = 45.8 bits (107), Expect = 1e-04 Identities = 45/158 (28%), Positives = 70/158 (44%), Gaps = 32/158 (20%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454 + + EEGE + +G E + GEG G +G E ++E +EE Sbjct: 947 EGEEEEGEWEGEEEEGEGEGEEEG---EGEGEEGEG-EGEEEEGEGEGEEEEGEEEGEEE 1002 Query: 455 SDEEEE-----EEEEE---------EEEEATDSEEE-----EDLEQMQEGQED--DEEED 493 + EEE EEEEE EE E EEE E+ E+ EG+E+ + EE+ Sbjct: 1003 GEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEE 1062 Query: 494 EEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSG 531 EEEE + G++ + ++ E K++S+ G Sbjct: 1063 EEEEGKYQETGEEE-------NERQDGEEYKKVSKIKG 1093 Score = 36.2 bits (82), Expect = 0.11 Identities = 55/247 (22%), Positives = 94/247 (38%), Gaps = 21/247 (8%) Query: 447 TDDEDDEESDEEEEEEE--EEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDG 504 T D E+D+ +E EE E +E +A + + Q + DEE E K+G Sbjct: 533 TQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEG 592 Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSE----EPLAPSSIDAESN 560 + S E+ +E ++ + G ++ K I+S L + E A S +AE Sbjct: 593 AED--SKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDG 650 Query: 561 GEQPEELTLEEESPVSQLFELEIEAL--------PLDTPSSVETDISSS----RKQSEEP 608 E + T EE S ++ ++ E ++ P E +++ ++ EE Sbjct: 651 PEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQ 710 Query: 609 FTTVLENGAGMVSSTSFN-GGVSPHNWGDSGPPCKKSRKEKKQTGSGPLGNSYVERQRSV 667 E G + GG H G+ ++ +EK+ G VE +R Sbjct: 711 EQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREK 770 Query: 668 HEKNGKK 674 E KK Sbjct: 771 EEGERKK 777 Score = 30.8 bits (68), Expect = 4.8 Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 12/116 (10%) Query: 423 ASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQM 482 + + G+ SQG A T + +E E EE+E E+ + EE+E Sbjct: 551 SEMKEGKACKQHVSQGIFMTQPATTIEAFSDEEVEIPEEKEGAEDSKGNGIEEQE----- 605 Query: 483 QEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGR 538 E +EE G +K+ + S ++++ + GK S E +GR Sbjct: 606 -------VEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGR 654 >gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform 9 [Homo sapiens] Length = 771 Score = 62.0 bits (149), Expect = 2e-09 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 K E+ E + + LQ S T A S E SG S E ++E++EE Sbjct: 242 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 294 Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511 EEEEEEEEEEEEE + EE + +E E++ EDEE E Sbjct: 295 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 340 Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569 NE +L P + R SGE + V L +S P EL Sbjct: 341 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 396 Query: 570 E 570 E Sbjct: 397 E 397 Score = 48.9 bits (115), Expect = 2e-05 Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 26/169 (15%) Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453 LQD S+ ERK A S S E + E G S+ S E ++E++E Sbjct: 255 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 311 Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501 E+ EE E+ EE ++ E ED E+ E ++ E E+ EEE G Sbjct: 312 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 371 Query: 502 ------KDGDKSP----MSSLQISNE-KNLEPGKQISRSSGEQQNKGRI 539 +GD P +S +++ E P Q RS E Q RI Sbjct: 372 PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 420 Score = 46.2 bits (108), Expect = 1e-04 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449 +++ E RK+R AR + S+H E D + S P R E D Sbjct: 183 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 241 Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507 E EE D + ++ + E T S E E +E++EEE+EEEE + + + Sbjct: 242 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 301 Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563 + E+ ++ S S E+ ++ + E + S D +S + Sbjct: 302 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 361 Query: 564 PEELTLEEESPVS 576 E + E +P S Sbjct: 362 EAEEEVGEGTPQS 374 Score = 36.6 bits (83), Expect = 0.088 Identities = 48/230 (20%), Positives = 91/230 (39%), Gaps = 13/230 (5%) Query: 390 KYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD 449 K+A +++K E ER+KR Q + + + E + + + E Sbjct: 109 KHARVKEKEREHERRKRHREEQDKARREWERQKRR----EMAREHSRRERDRLEQLERKR 164 Query: 450 EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQE--GQEDDEEEDEEEEAAA---GKDG 504 E + + E+++E+ E++E E E ++ E +E ED ++ A + Sbjct: 165 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 224 Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQP 564 + P ++ + + +P K+ + + + +S S SS ++ S E+ Sbjct: 225 PRPPRERFELGDGR--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 282 Query: 565 EELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLE 614 EE EEE S E E E + E S+S + SE+ V E Sbjct: 283 EEEEEEEEEEGSTSEESEEE--EEEEEEEEEETGSNSEEASEQSAEEVSE 330 Score = 32.7 bits (73), Expect = 1.3 Identities = 39/182 (21%), Positives = 75/182 (41%), Gaps = 25/182 (13%) Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGE-GPSG 433 E S + LDE++ + +++ E+ E K+ + +S D+ SL+ GE Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLK------NSDDRDSKRDSLEEGELRDHC 57 Query: 434 MASQGCPSASRAETDDEDDEESDE-----------------EEEEEEEEEEEEATDSEEE 476 M S R E ED E D+ ++E+ +E++ A E+E Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKE 117 Query: 477 EDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNK 536 + E+ + +E+ ++ E E ++ + S + + LE ++ R EQQ + Sbjct: 118 REHERRKRHREEQDKARREWERQKRREMARE-HSRRERDRLEQLERKRERERKMREQQKE 176 Query: 537 GR 538 R Sbjct: 177 QR 178 Score = 30.8 bits (68), Expect = 4.8 Identities = 51/242 (21%), Positives = 89/242 (36%), Gaps = 26/242 (10%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASL-DSGEGPSGMASQGCPSASRAET----DD 449 +D EEGE + + T +S E S+ D GE +A + SR E D Sbjct: 45 RDSLEEGELRDHCMEI--TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102 Query: 450 EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPM 509 E +E +E+E E E EE+D + + + E + E A ++ + Sbjct: 103 EKRKEKKHARVKEKEREHERRKRHREEQD-----KARREWERQKRREMAREHSRRERDRL 157 Query: 510 SSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSI------DAESNGEQ 563 L+ E+ + +Q + EQ+ + R E S + S+ + Sbjct: 158 EQLERKRERERKMREQ-QKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVK 216 Query: 564 PEELTLEEESPVSQLFELEIEALPLDTPSSVE-------TDISSSRKQSEEPFTTVLENG 616 + P + FEL P+ E DIS S +++ ++ E+G Sbjct: 217 ASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 276 Query: 617 AG 618 +G Sbjct: 277 SG 278 >gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform 8 [Homo sapiens] Length = 780 Score = 62.0 bits (149), Expect = 2e-09 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 K E+ E + + LQ S T A S E SG S E ++E++EE Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 303 Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511 EEEEEEEEEEEEE + EE + +E E++ EDEE E Sbjct: 304 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 349 Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569 NE +L P + R SGE + V L +S P EL Sbjct: 350 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 405 Query: 570 E 570 E Sbjct: 406 E 406 Score = 49.3 bits (116), Expect = 1e-05 Identities = 60/268 (22%), Positives = 103/268 (38%), Gaps = 26/268 (9%) Query: 298 YGDVLRAVEKAAARHSLGLPRQQLQLMAQDAFRDVGIRLQERRHLDLIYNFGCHLTDDYR 357 + D L +E+ R +Q+ Q ++ R R +ER + + +DY Sbjct: 162 FRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYS 221 Query: 358 PGVDPALSDPVLARRLRENRSLAMSRL---DEVISKYAMLQDKSEEGERKKRRARLQGTS 414 V + R RE L R +E + + +L D + + +++ + + +S Sbjct: 222 DKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSS 281 Query: 415 SHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSE 474 + S E + E S S E ++E++EE+ EE E+ EE ++ E Sbjct: 282 AESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEE 341 Query: 475 EEEDLEQMQEG-----------QEDDEEEDEEEEAAAG-------KDGDKSP----MSSL 512 ED E+ E ++ E E+ EEE G +GD P +S + Sbjct: 342 MSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI 401 Query: 513 QISNE-KNLEPGKQISRSSGEQQNKGRI 539 ++ E P Q RS E Q RI Sbjct: 402 ELKQELPKYLPALQGCRSVEEFQCLNRI 429 Score = 40.0 bits (92), Expect = 0.008 Identities = 42/193 (21%), Positives = 74/193 (38%), Gaps = 12/193 (6%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454 +++ E RK+R AR + S+H E D + S P R E D Sbjct: 192 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 250 Query: 455 SDEEEEEEEEEEE-EEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQ 513 +E+ EE + + ++ +DSE + + + E+EEEE ++ + S + Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 310 Query: 514 ISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEP----------LAPSSIDAESNGEQ 563 E+ E + S S + VS +SE+ + S D +S + Sbjct: 311 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 370 Query: 564 PEELTLEEESPVS 576 E + E +P S Sbjct: 371 EAEEEVGEGTPQS 383 Score = 36.2 bits (82), Expect = 0.11 Identities = 50/239 (20%), Positives = 90/239 (37%), Gaps = 22/239 (9%) Query: 390 KYAMLQDKSEEGERKKR------RARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSAS 443 K+A +++K E ER+KR +AR + + G G+ C Sbjct: 109 KHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDGV----CLFRD 164 Query: 444 RAE-----TDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEA 498 R E + E ++E+ E++E E A + +E + + ED ++ Sbjct: 165 RLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKV 224 Query: 499 AA---GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSI 555 A + + P ++ + + +P K+ + + + +S S SS Sbjct: 225 KASHWSRSPPRPPRERFELGDGR--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSA 282 Query: 556 DAESNGEQPEELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLE 614 ++ S E+ EE EEE S E E E + E S+S + SE+ V E Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEESEEE--EEEEEEEEEETGSNSEEASEQSAEEVSE 339 Score = 34.7 bits (78), Expect = 0.33 Identities = 39/150 (26%), Positives = 59/150 (39%), Gaps = 13/150 (8%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASL-DSGEGPSGMASQGCPSASRAET-----D 448 +D EEGE + + T +S E S+ D GE +A + SR E D Sbjct: 45 RDSLEEGELRDHCMEI--TIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKD 102 Query: 449 DEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSP 508 ++ E+ +E+E E E EE++ + E Q+ E E G DG Sbjct: 103 EKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERGNDG---- 158 Query: 509 MSSLQISNEKNLEPGKQISRSSGEQQNKGR 538 L + LE ++ R EQQ + R Sbjct: 159 -VCLFRDRLEQLERKRERERKMREQQKEQR 187 >gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform 5 [Homo sapiens] Length = 748 Score = 62.0 bits (149), Expect = 2e-09 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 K E+ E + + LQ S T A S E SG S E ++E++EE Sbjct: 219 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 271 Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511 EEEEEEEEEEEEE + EE + +E E++ EDEE E Sbjct: 272 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 317 Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569 NE +L P + R SGE + V L +S P EL Sbjct: 318 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 373 Query: 570 E 570 E Sbjct: 374 E 374 Score = 48.9 bits (115), Expect = 2e-05 Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 26/169 (15%) Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453 LQD S+ ERK A S S E + E G S+ S E ++E++E Sbjct: 232 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 288 Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501 E+ EE E+ EE ++ E ED E+ E ++ E E+ EEE G Sbjct: 289 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 348 Query: 502 ------KDGDKSP----MSSLQISNE-KNLEPGKQISRSSGEQQNKGRI 539 +GD P +S +++ E P Q RS E Q RI Sbjct: 349 PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 397 Score = 46.2 bits (108), Expect = 1e-04 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449 +++ E RK+R AR + S+H E D + S P R E D Sbjct: 160 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 218 Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507 E EE D + ++ + E T S E E +E++EEE+EEEE + + + Sbjct: 219 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 278 Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563 + E+ ++ S S E+ ++ + E + S D +S + Sbjct: 279 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 338 Query: 564 PEELTLEEESPVS 576 E + E +P S Sbjct: 339 EAEEEVGEGTPQS 351 Score = 36.6 bits (83), Expect = 0.088 Identities = 48/230 (20%), Positives = 91/230 (39%), Gaps = 13/230 (5%) Query: 390 KYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD 449 K+A +++K E ER+KR Q + + + E + + + E Sbjct: 86 KHARVKEKEREHERRKRHREEQDKARREWERQKRR----EMAREHSRRERDRLEQLERKR 141 Query: 450 EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQE--GQEDDEEEDEEEEAAA---GKDG 504 E + + E+++E+ E++E E E ++ E +E ED ++ A + Sbjct: 142 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 201 Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQP 564 + P ++ + + +P K+ + + + +S S SS ++ S E+ Sbjct: 202 PRPPRERFELGDGR--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 259 Query: 565 EELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLE 614 EE EEE S E E E + E S+S + SE+ V E Sbjct: 260 EEEEEEEEEEGSTSEESEEE--EEEEEEEEEETGSNSEEASEQSAEEVSE 307 >gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform 4 [Homo sapiens] Length = 737 Score = 62.0 bits (149), Expect = 2e-09 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 K E+ E + + LQ S T A S E SG S E ++E++EE Sbjct: 208 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 260 Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511 EEEEEEEEEEEEE + EE + +E E++ EDEE E Sbjct: 261 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 306 Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569 NE +L P + R SGE + V L +S P EL Sbjct: 307 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 362 Query: 570 E 570 E Sbjct: 363 E 363 Score = 48.9 bits (115), Expect = 2e-05 Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 26/169 (15%) Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453 LQD S+ ERK A S S E + E G S+ S E ++E++E Sbjct: 221 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 277 Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501 E+ EE E+ EE ++ E ED E+ E ++ E E+ EEE G Sbjct: 278 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 337 Query: 502 ------KDGDKSP----MSSLQISNE-KNLEPGKQISRSSGEQQNKGRI 539 +GD P +S +++ E P Q RS E Q RI Sbjct: 338 PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 386 Score = 46.2 bits (108), Expect = 1e-04 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449 +++ E RK+R AR + S+H E D + S P R E D Sbjct: 149 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 207 Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507 E EE D + ++ + E T S E E +E++EEE+EEEE + + + Sbjct: 208 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 267 Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563 + E+ ++ S S E+ ++ + E + S D +S + Sbjct: 268 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 327 Query: 564 PEELTLEEESPVS 576 E + E +P S Sbjct: 328 EAEEEVGEGTPQS 340 Score = 34.3 bits (77), Expect = 0.44 Identities = 59/267 (22%), Positives = 101/267 (37%), Gaps = 37/267 (13%) Query: 381 MSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASL-DSGEGPSGMASQGC 439 MS+ D+ SK +D EEGE + R + T +S E S+ D GE +A + Sbjct: 1 MSQSDDRDSK----RDSLEEGELRDHRMEI--TIRNSPYRREDSMEDRGEEDDSLAIKPP 54 Query: 440 PSASRAET-----DDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDE---- 490 SR E D++ E+ +E+E E E EE++ + E Q+ E Sbjct: 55 QQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMARE 114 Query: 491 ----EEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRI------- 539 E D E+ ++ ++ M Q + E ++ E++ + + Sbjct: 115 HSRRERDRLEQLERKRERERK-MREQQKEQREQKERERRAEERRKEREARREVSAHHRTM 173 Query: 540 -------VSPSLLSEEPLAPSSIDAE-SNGEQP-EELTLEEESPVSQLFELEIEALPLDT 590 V S S P P E +G +P +E +EE +S L ++ + Sbjct: 174 REDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSS 233 Query: 591 PSSVETDISSSRKQSEEPFTTVLENGA 617 S + S ++ EE E G+ Sbjct: 234 AESSSAESGSGSEEEEEEEEEEEEEGS 260 >gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform 2 [Homo sapiens] Length = 782 Score = 62.0 bits (149), Expect = 2e-09 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 K E+ E + + LQ S T A S E SG S E ++E++EE Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 305 Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511 EEEEEEEEEEEEE + EE + +E E++ EDEE E Sbjct: 306 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 351 Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569 NE +L P + R SGE + V L +S P EL Sbjct: 352 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQ 407 Query: 570 E 570 E Sbjct: 408 E 408 Score = 48.9 bits (115), Expect = 2e-05 Identities = 48/169 (28%), Positives = 68/169 (40%), Gaps = 26/169 (15%) Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453 LQD S+ ERK A S S E + E G S+ S E ++E++E Sbjct: 266 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 322 Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501 E+ EE E+ EE ++ E ED E+ E ++ E E+ EEE G Sbjct: 323 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 382 Query: 502 ------KDGDKSP----MSSLQISNE-KNLEPGKQISRSSGEQQNKGRI 539 +GD P +S +++ E P Q RS E Q RI Sbjct: 383 PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRI 431 Score = 46.2 bits (108), Expect = 1e-04 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449 +++ E RK+R AR + S+H E D + S P R E D Sbjct: 194 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 252 Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507 E EE D + ++ + E T S E E +E++EEE+EEEE + + + Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 312 Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563 + E+ ++ S S E+ ++ + E + S D +S + Sbjct: 313 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 372 Query: 564 PEELTLEEESPVS 576 E + E +P S Sbjct: 373 EAEEEVGEGTPQS 385 Score = 36.6 bits (83), Expect = 0.088 Identities = 48/230 (20%), Positives = 91/230 (39%), Gaps = 13/230 (5%) Query: 390 KYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD 449 K+A +++K E ER+KR Q + + + E + + + E Sbjct: 120 KHARVKEKEREHERRKRHREEQDKARREWERQKRR----EMAREHSRRERDRLEQLERKR 175 Query: 450 EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQE--GQEDDEEEDEEEEAAA---GKDG 504 E + + E+++E+ E++E E E ++ E +E ED ++ A + Sbjct: 176 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 235 Query: 505 DKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQP 564 + P ++ + + +P K+ + + + +S S SS ++ S E+ Sbjct: 236 PRPPRERFELGDGR--KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 293 Query: 565 EELTLEEESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTTVLE 614 EE EEE S E E E + E S+S + SE+ V E Sbjct: 294 EEEEEEEEEEGSTSEESEEE--EEEEEEEEEETGSNSEEASEQSAEEVSE 341 >gi|115529449 upstream binding transcription factor, RNA polymerase I isoform b [Homo sapiens] Length = 727 Score = 61.6 bits (148), Expect = 3e-09 Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 8/101 (7%) Query: 424 SLDSGEGPSGMASQGC-PSASRAETDDEDDEESDEEEEEEEEEEE----EEATDSEE--- 475 S+ GP+ +S+ S S +E DDE+DE+ ++E+EEEE++E E+ DS E Sbjct: 618 SMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSS 677 Query: 476 EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516 E++ E E +EDDE+ED++E+ +D + SS S+ Sbjct: 678 EDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 718 Score = 43.5 bits (101), Expect = 7e-04 Identities = 34/130 (26%), Positives = 51/130 (39%), Gaps = 17/130 (13%) Query: 386 EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSAS-- 443 E IS K K R LQ S D E D E + S+ Sbjct: 610 EYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDG 669 Query: 444 --RAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAG 501 +E+ ED+ E +E EE++E+E D +E++D ED++ E E +++ Sbjct: 670 GDSSESSSEDESEDGDENEEDDEDE-----DDDEDDD--------EDEDNESEGSSSSSS 716 Query: 502 KDGDKSPMSS 511 GD S S Sbjct: 717 SSGDSSDSDS 726 Score = 41.6 bits (96), Expect = 0.003 Identities = 30/121 (24%), Positives = 50/121 (41%), Gaps = 20/121 (16%) Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499 P +SR + + E D+EE+E++E+E+EE +EDDE D E+ Sbjct: 627 PKSSRTTLQSKSESEEDDEEDEDDEDEDEE----------------EEDDENGDSSEDGG 670 Query: 500 AGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAES 559 + S NE++ E ++ N+ S S S + S D++S Sbjct: 671 DSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS----SGDSSDSDS 726 Query: 560 N 560 N Sbjct: 727 N 727 Score = 40.8 bits (94), Expect = 0.005 Identities = 24/99 (24%), Positives = 42/99 (42%) Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGM 434 + +S+ R S LQ KSE E + + D G S Sbjct: 615 KRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSE 674 Query: 435 ASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDS 473 +S S E +++D++E D+E+++E+E+ E E + S Sbjct: 675 SSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSS 713 Score = 31.2 bits (69), Expect = 3.7 Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 2/84 (2%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454 +D+ +E E ++ G SS D ++S S E S + + D++DDE+ Sbjct: 646 EDEDDEDEDEEEEDDENGDSSE--DGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 703 Query: 455 SDEEEEEEEEEEEEEATDSEEEED 478 D E E S+ + + Sbjct: 704 EDNESEGSSSSSSSSGDSSDSDSN 727 >gi|115529451 upstream binding transcription factor, RNA polymerase I isoform b [Homo sapiens] Length = 727 Score = 61.6 bits (148), Expect = 3e-09 Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 8/101 (7%) Query: 424 SLDSGEGPSGMASQGC-PSASRAETDDEDDEESDEEEEEEEEEEE----EEATDSEE--- 475 S+ GP+ +S+ S S +E DDE+DE+ ++E+EEEE++E E+ DS E Sbjct: 618 SMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSS 677 Query: 476 EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516 E++ E E +EDDE+ED++E+ +D + SS S+ Sbjct: 678 EDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 718 Score = 43.5 bits (101), Expect = 7e-04 Identities = 34/130 (26%), Positives = 51/130 (39%), Gaps = 17/130 (13%) Query: 386 EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSAS-- 443 E IS K K R LQ S D E D E + S+ Sbjct: 610 EYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDG 669 Query: 444 --RAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAG 501 +E+ ED+ E +E EE++E+E D +E++D ED++ E E +++ Sbjct: 670 GDSSESSSEDESEDGDENEEDDEDE-----DDDEDDD--------EDEDNESEGSSSSSS 716 Query: 502 KDGDKSPMSS 511 GD S S Sbjct: 717 SSGDSSDSDS 726 Score = 41.6 bits (96), Expect = 0.003 Identities = 30/121 (24%), Positives = 50/121 (41%), Gaps = 20/121 (16%) Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499 P +SR + + E D+EE+E++E+E+EE +EDDE D E+ Sbjct: 627 PKSSRTTLQSKSESEEDDEEDEDDEDEDEE----------------EEDDENGDSSEDGG 670 Query: 500 AGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAES 559 + S NE++ E ++ N+ S S S + S D++S Sbjct: 671 DSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS----SGDSSDSDS 726 Query: 560 N 560 N Sbjct: 727 N 727 Score = 40.8 bits (94), Expect = 0.005 Identities = 24/99 (24%), Positives = 42/99 (42%) Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGM 434 + +S+ R S LQ KSE E + + D G S Sbjct: 615 KRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSE 674 Query: 435 ASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDS 473 +S S E +++D++E D+E+++E+E+ E E + S Sbjct: 675 SSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSS 713 Score = 31.2 bits (69), Expect = 3.7 Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 2/84 (2%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454 +D+ +E E ++ G SS D ++S S E S + + D++DDE+ Sbjct: 646 EDEDDEDEDEEEEDDENGDSSE--DGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 703 Query: 455 SDEEEEEEEEEEEEEATDSEEEED 478 D E E S+ + + Sbjct: 704 EDNESEGSSSSSSSSGDSSDSDSN 727 >gi|7657671 upstream binding transcription factor, RNA polymerase I isoform a [Homo sapiens] Length = 764 Score = 61.6 bits (148), Expect = 3e-09 Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 8/101 (7%) Query: 424 SLDSGEGPSGMASQGC-PSASRAETDDEDDEESDEEEEEEEEEEE----EEATDSEE--- 475 S+ GP+ +S+ S S +E DDE+DE+ ++E+EEEE++E E+ DS E Sbjct: 655 SMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSESSS 714 Query: 476 EEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISN 516 E++ E E +EDDE+ED++E+ +D + SS S+ Sbjct: 715 EDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSSS 755 Score = 43.5 bits (101), Expect = 7e-04 Identities = 34/130 (26%), Positives = 51/130 (39%), Gaps = 17/130 (13%) Query: 386 EVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSAS-- 443 E IS K K R LQ S D E D E + S+ Sbjct: 647 EYISNKRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDG 706 Query: 444 --RAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAG 501 +E+ ED+ E +E EE++E+E D +E++D ED++ E E +++ Sbjct: 707 GDSSESSSEDESEDGDENEEDDEDE-----DDDEDDD--------EDEDNESEGSSSSSS 753 Query: 502 KDGDKSPMSS 511 GD S S Sbjct: 754 SSGDSSDSDS 763 Score = 41.6 bits (96), Expect = 0.003 Identities = 30/121 (24%), Positives = 50/121 (41%), Gaps = 20/121 (16%) Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499 P +SR + + E D+EE+E++E+E+EE +EDDE D E+ Sbjct: 664 PKSSRTTLQSKSESEEDDEEDEDDEDEDEE----------------EEDDENGDSSEDGG 707 Query: 500 AGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAES 559 + S NE++ E ++ N+ S S S + S D++S Sbjct: 708 DSSESSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSSSSSS----SGDSSDSDS 763 Query: 560 N 560 N Sbjct: 764 N 764 Score = 40.8 bits (94), Expect = 0.005 Identities = 24/99 (24%), Positives = 42/99 (42%) Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGM 434 + +S+ R S LQ KSE E + + D G S Sbjct: 652 KRKSMTKLRGPNPKSSRTTLQSKSESEEDDEEDEDDEDEDEEEEDDENGDSSEDGGDSSE 711 Query: 435 ASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDS 473 +S S E +++D++E D+E+++E+E+ E E + S Sbjct: 712 SSSEDESEDGDENEEDDEDEDDDEDDDEDEDNESEGSSS 750 Score = 31.2 bits (69), Expect = 3.7 Identities = 19/84 (22%), Positives = 34/84 (40%), Gaps = 2/84 (2%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEE 454 +D+ +E E ++ G SS D ++S S E S + + D++DDE+ Sbjct: 683 EDEDDEDEDEEEEDDENGDSSE--DGGDSSESSSEDESEDGDENEEDDEDEDDDEDDDED 740 Query: 455 SDEEEEEEEEEEEEEATDSEEEED 478 D E E S+ + + Sbjct: 741 EDNESEGSSSSSSSSGDSSDSDSN 764 >gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] Length = 770 Score = 61.2 bits (147), Expect = 3e-09 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 K E+ E + + LQ S T A S E SG S E ++E++EE Sbjct: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 293 Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511 EEEEEEEEEEEEE + EE + +E E++ EDEE E Sbjct: 294 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 339 Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569 NE +L P + R SGE + V L +S P EL Sbjct: 340 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ 395 Query: 570 E 570 E Sbjct: 396 E 396 Score = 49.3 bits (116), Expect = 1e-05 Identities = 49/169 (28%), Positives = 66/169 (39%), Gaps = 26/169 (15%) Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453 LQD S+ ERK A S S E + E G S+ S E ++E++E Sbjct: 254 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 310 Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501 E+ EE E+ EE ++ E ED E+ E ++ E E+ EEE G Sbjct: 311 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 370 Query: 502 ------KDGDKSPMSSLQISNEKNLE-----PGKQISRSSGEQQNKGRI 539 +GD P S + E E P Q RS E Q RI Sbjct: 371 PQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRI 419 Score = 46.2 bits (108), Expect = 1e-04 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449 +++ E RK+R AR + S+H E D + S P R E D Sbjct: 182 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 240 Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507 E EE D + ++ + E T S E E +E++EEE+EEEE + + + Sbjct: 241 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 300 Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563 + E+ ++ S S E+ ++ + E + S D +S + Sbjct: 301 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 360 Query: 564 PEELTLEEESPVS 576 E + E +P S Sbjct: 361 EAEEEVGEGTPQS 373 Score = 35.8 bits (81), Expect = 0.15 Identities = 57/257 (22%), Positives = 92/257 (35%), Gaps = 29/257 (11%) Query: 395 QDKSE-EGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453 QDK+ E ER+KRR + S D E E M Q + E + +E Sbjct: 129 QDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 188 Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLE----------------QMQEGQEDDEEEDEEEE 497 E E E + + ++ ++ +G++ +EE EE Sbjct: 189 RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER 248 Query: 498 AAAGKDGDKS----PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPS 553 D S SS + S+ ++ ++ E++ +G S EE Sbjct: 249 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEE 308 Query: 554 SIDAESNGEQPEELTLEE--ESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTT 611 + SN E+ E + EE E +S+ E E E L P S S +++EE Sbjct: 309 EEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE---- 364 Query: 612 VLENGAGMVSSTSFNGG 628 E G G S++ G Sbjct: 365 --EVGEGTPQSSALTEG 379 Score = 30.0 bits (66), Expect = 8.2 Identities = 36/180 (20%), Positives = 74/180 (41%), Gaps = 22/180 (12%) Query: 375 ENRSLAMSRLDEVISKYAMLQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGE-GPSG 433 E S + LDE++ + +++ E+ E K+ + +S D+ SL+ GE Sbjct: 4 EKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLK------NSDDRDSKRDSLEEGELRDHC 57 Query: 434 MASQGCPSASRAETDDEDDEESDEE------EEEEEEEEEEEATDSEEEEDLE--QMQEG 485 M S R E ED E D+ ++ +E+ D + +E + +++E Sbjct: 58 MEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKER 117 Query: 486 QEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEK-------NLEPGKQISRSSGEQQNKGR 538 + + + EE+ A ++ ++ + + + LE ++ R EQQ + R Sbjct: 118 EHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQR 177 >gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] Length = 780 Score = 61.2 bits (147), Expect = 3e-09 Identities = 54/181 (29%), Positives = 70/181 (38%), Gaps = 32/181 (17%) Query: 397 KSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESD 456 K E+ E + + LQ S T A S E SG S E ++E++EE Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG-------SEEEEEEEEEEEEEGS 303 Query: 457 -----EEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSS 511 EEEEEEEEEEEEE + EE + +E E++ EDEE E Sbjct: 304 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE-------------- 349 Query: 512 LQISNEKNL--EPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTL 569 NE +L P + R SGE + V L +S P EL Sbjct: 350 ----NENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQ 405 Query: 570 E 570 E Sbjct: 406 E 406 Score = 49.3 bits (116), Expect = 1e-05 Identities = 49/169 (28%), Positives = 66/169 (39%), Gaps = 26/169 (15%) Query: 394 LQDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453 LQD S+ ERK A S S E + E G S+ S E ++E++E Sbjct: 264 LQDISDS-ERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSE--ESEEEEEEEEEEEE 320 Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLEQMQEG-----------QEDDEEEDEEEEAAAG- 501 E+ EE E+ EE ++ E ED E+ E ++ E E+ EEE G Sbjct: 321 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGT 380 Query: 502 ------KDGDKSPMSSLQISNEKNLE-----PGKQISRSSGEQQNKGRI 539 +GD P S + E E P Q RS E Q RI Sbjct: 381 PQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRI 429 Score = 46.2 bits (108), Expect = 1e-04 Identities = 44/193 (22%), Positives = 75/193 (38%), Gaps = 12/193 (6%) Query: 395 QDKSEEGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDD----- 449 +++ E RK+R AR + S+H E D + S P R E D Sbjct: 192 RERRAEERRKEREARRE-VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 250 Query: 450 --EDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKS 507 E EE D + ++ + E T S E E +E++EEE+EEEE + + + Sbjct: 251 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEE 310 Query: 508 PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE----PLAPSSIDAESNGEQ 563 + E+ ++ S S E+ ++ + E + S D +S + Sbjct: 311 EEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESE 370 Query: 564 PEELTLEEESPVS 576 E + E +P S Sbjct: 371 EAEEEVGEGTPQS 383 Score = 35.8 bits (81), Expect = 0.15 Identities = 57/257 (22%), Positives = 92/257 (35%), Gaps = 29/257 (11%) Query: 395 QDKSE-EGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDE 453 QDK+ E ER+KRR + S D E E M Q + E + +E Sbjct: 139 QDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 198 Query: 454 ESDEEEEEEEEEEEEEATDSEEEEDLE----------------QMQEGQEDDEEEDEEEE 497 E E E + + ++ ++ +G++ +EE EE Sbjct: 199 RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER 258 Query: 498 AAAGKDGDKS----PMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPS 553 D S SS + S+ ++ ++ E++ +G S EE Sbjct: 259 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEE 318 Query: 554 SIDAESNGEQPEELTLEE--ESPVSQLFELEIEALPLDTPSSVETDISSSRKQSEEPFTT 611 + SN E+ E + EE E +S+ E E E L P S S +++EE Sbjct: 319 EEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEE---- 374 Query: 612 VLENGAGMVSSTSFNGG 628 E G G S++ G Sbjct: 375 --EVGEGTPQSSALTEG 389 >gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens] Length = 1341 Score = 60.8 bits (146), Expect = 4e-09 Identities = 78/335 (23%), Positives = 139/335 (41%), Gaps = 42/335 (12%) Query: 301 VLRAVEKAAARHSLGLPRQQL-QLMAQDAFRDVGIRLQE---RRHLDLIYNFGCHLTDDY 356 +L ++K + H+ P Q+ + M+Q++F + Q+ R+ L+ L + Sbjct: 107 MLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEAS 166 Query: 357 RPGVDPALSDPVLARRLRENRSLAMSRLDEVISKYA------MLQDKSEEGERKKRRARL 410 D + +A L + ++ R + +S+++ + ++K + + K R+ Sbjct: 167 AESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDDEKPRKGER 226 Query: 411 QGTSSHSADTPEASLDSGEGPSGMAS-QGCPSAS-------RAETDDEDDEESDEEEEEE 462 + SS A L G P+ Q PS + +T++E++EE +EEE++E Sbjct: 227 R--SSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDE 284 Query: 463 EEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEP 522 EEE ++E S E L++ +E E+ EE D+ P + Q ++ LE Sbjct: 285 EEEGDDEGQKSREAPILKEFKEEGEEIPRVKPEEMM------DERPKTRSQ--EQEVLER 336 Query: 523 GKQISRSSGE---------QQNKGRIVSPSLLSEEPLAPSSIDAESNGEQPEELTLEEES 573 G + +RS E QQ K + L EE SS + + P L E+ Sbjct: 337 GGRFTRSQEEARKSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDR 396 Query: 574 PVSQLFELEIEALPLDTPSSVETDISSSRKQSEEP 608 + L ALP T S ET K++ P Sbjct: 397 KKASLV-----ALPEQTASEEETPPPLLTKEASSP 426 Score = 43.5 bits (101), Expect = 7e-04 Identities = 30/98 (30%), Positives = 51/98 (52%), Gaps = 9/98 (9%) Query: 442 ASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAG 501 A RAE E ++ E+EEEE++E E+EA + E LE+ ++ +E E D E E Sbjct: 1239 AERAERAKEREKRRKEQEEEEQKEREKEA-ERERNRQLER-EKRREHSRERDRERERERE 1296 Query: 502 KD-GDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGR 538 +D GD+ E++ E G++ R ++ ++ R Sbjct: 1297 RDRGDRDR------DRERDRERGRERDRRDTKRHSRSR 1328 Score = 35.4 bits (80), Expect = 0.20 Identities = 37/174 (21%), Positives = 72/174 (41%), Gaps = 16/174 (9%) Query: 400 EGERKKRRARLQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEE 459 EG + R+ R +++ + P S+ + E + P A + D ++S E Sbjct: 841 EGGQPGRKRRWGASTATTQKKPSISITT-ESLKSLIPDIKPLAGQEAVVDLHADDSRISE 899 Query: 460 EEEEEEEEEEATDSEEEEDLEQMQ----EGQEDDEEEDEEEEAAAGKDGDKSPMSSLQIS 515 +E E ++ D + Q EGQE+ + E+EEEE + P S++++ Sbjct: 900 DETERNGDDGTHDKGLKICRTVTQVVPAEGQENGQREEEEEEKEPEAEPPVPPQVSVEVA 959 Query: 516 -------NEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEEPLAPSSIDAESNGE 562 K + G ++R S QQ G S+ ++P+ + + + G+ Sbjct: 960 LPPPAEHEVKKVTLGDTLTRRSISQQKSG----VSITIDDPVRTAQVPSPPRGK 1009 Score = 33.5 bits (75), Expect = 0.75 Identities = 18/67 (26%), Positives = 29/67 (43%) Query: 440 PSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAA 499 P RAE +++ ++ E E E E E T SE E D ++++EG + Sbjct: 1128 PQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSRSRDRRRKE 1187 Query: 500 AGKDGDK 506 K +K Sbjct: 1188 RAKSKEK 1194 Score = 32.0 bits (71), Expect = 2.2 Identities = 15/67 (22%), Positives = 38/67 (56%) Query: 467 EEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQI 526 ++EA +E ++ E+ ++ QE++E+++ E+EA ++ + S E++ E ++ Sbjct: 1236 QKEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERER 1295 Query: 527 SRSSGEQ 533 R G++ Sbjct: 1296 ERDRGDR 1302 >gi|21361639 DIPB protein [Homo sapiens] Length = 344 Score = 60.5 bits (145), Expect = 6e-09 Identities = 38/135 (28%), Positives = 67/135 (49%), Gaps = 6/135 (4%) Query: 422 EASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQ 481 E ++S G + + S +ET++E ++ESDEE EE+ EEE E+ +SE EED Sbjct: 88 EREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEED--- 144 Query: 482 MQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVS 541 QE+ E E E E A + + M + +++ K + G +S E + ++ Sbjct: 145 ---NQEEGESEAEGETEAESEFDPEIEMEAERVAKRKCPDHGLDLSTYCQEDRQLICVLC 201 Query: 542 PSLLSEEPLAPSSID 556 P + + + S++D Sbjct: 202 PVIGAHQGHQLSTLD 216 Score = 55.1 bits (131), Expect = 2e-07 Identities = 29/79 (36%), Positives = 46/79 (58%), Gaps = 1/79 (1%) Query: 444 RAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEE-DEEEEAAAGK 502 + E + E + E+ EE E EEE E EE +++EEE + E +E +ED EEE ++E+E+ A + Sbjct: 84 KVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEE 143 Query: 503 DGDKSPMSSLQISNEKNLE 521 D + S + E E Sbjct: 144 DNQEEGESEAEGETEAESE 162 Score = 50.8 bits (120), Expect = 5e-06 Identities = 39/109 (35%), Positives = 52/109 (47%), Gaps = 11/109 (10%) Query: 420 TPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDEEEEEE-E-----EEEEEEATDS 473 TP A GEG +G E + E EES+ EEE E E EEE E+ +D Sbjct: 68 TPPAD---GEG-AGKEEAEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDE 123 Query: 474 EEEEDL-EQMQEGQEDDEEEDEEEEAAAGKDGDKSPMSSLQISNEKNLE 521 E EED E+M++ QE + EED +EE + +G+ S E E Sbjct: 124 ESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPEIEMEAE 172 Score = 48.5 bits (114), Expect = 2e-05 Identities = 31/94 (32%), Positives = 50/94 (53%), Gaps = 12/94 (12%) Query: 442 ASRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDE-EEDEEEEAAA 500 A + E + + ++E + E E EE E EE ++SEEE + E+ E + D+E EED EEE Sbjct: 76 AGKEEAEVKVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMED 135 Query: 501 GKDGDKSPMSSLQISNEKNLEPGKQISRSSGEQQ 534 ++ + + E N E G+ S + GE + Sbjct: 136 EQESE---------AEEDNQEEGE--SEAEGETE 158 Score = 44.3 bits (103), Expect = 4e-04 Identities = 32/108 (29%), Positives = 54/108 (50%), Gaps = 6/108 (5%) Query: 399 EEGERKKRRAR-LQGTSSHSADTPEASLDSGEGPSGMASQGCPSASRAETDDEDDEESDE 457 EE E K + R ++ + +++ E S E + S+ S E++++ +EE ++ Sbjct: 79 EEAEVKVEQEREIESEAGEESESEEESESEEESETEEESE---DESDEESEEDSEEEMED 135 Query: 458 EEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGKDGD 505 E+E E EE+ +E +SE E + E E + D E E E E A K D Sbjct: 136 EQESEAEEDNQEEGESEAEGETE--AESEFDPEIEMEAERVAKRKCPD 181 Score = 41.6 bits (96), Expect = 0.003 Identities = 28/106 (26%), Positives = 49/106 (46%), Gaps = 3/106 (2%) Query: 443 SRAETDDEDDEESDEEEEEEEEEEEEEATDSEEEEDLEQMQEGQEDDEEEDEEEEAAAGK 502 S+A T D E + +EE E + E+E E E E E E + + EEE E EE + + Sbjct: 64 SQAWTPPADGEGAGKEEAEVKVEQEREI---ESEAGEESESEEESESEEESETEEESEDE 120 Query: 503 DGDKSPMSSLQISNEKNLEPGKQISRSSGEQQNKGRIVSPSLLSEE 548 ++S S + ++ ++ ++ GE + +G + S E Sbjct: 121 SDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAESEFDPE 166 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.308 0.127 0.355 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 34,297,828 Number of Sequences: 37866 Number of extensions: 1949065 Number of successful extensions: 76700 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 1223 Number of HSP's successfully gapped in prelim test: 1031 Number of HSP's that attempted gapping in prelim test: 19252 Number of HSP's gapped (non-prelim): 19298 length of query: 752 length of database: 18,247,518 effective HSP length: 110 effective length of query: 642 effective length of database: 14,082,258 effective search space: 9040809636 effective search space used: 9040809636 T: 11 A: 40 X1: 16 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.6 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.