Guide to the Human Genome
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Search of human proteins with 21493029

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
         (2813 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]      5563   0.0  
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]      5520   0.0  
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]      2061   0.0  
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo...   597   e-170
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor...   597   e-170
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]    588   e-167
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor...   585   e-166
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor...   585   e-166
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor...   574   e-163
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [...   189   3e-47
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [...   189   3e-47
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [...   189   3e-47
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof...   178   8e-44
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo...   178   8e-44
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo...   169   5e-41
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ...    82   1e-14
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ...    82   1e-14
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H...    82   1e-14
gi|38373682 pleckstrin homology domain containing family G membe...    79   8e-14
gi|111154084 pleckstrin homology domain containing family G memb...    79   8e-14
gi|111154088 pleckstrin homology domain containing family G memb...    79   8e-14
gi|111154080 pleckstrin homology domain containing family G memb...    79   8e-14
gi|111154078 pleckstrin homology domain containing family G memb...    79   8e-14
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ...    78   1e-13
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [...    78   1e-13
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]    77   3e-13
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                76   5e-13
gi|194294523 intersectin 2 isoform 3 [Homo sapiens]                    75   1e-12
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    75   1e-12
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    72   1e-11

>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
          Length = 2813

 Score = 5563 bits (14430), Expect = 0.0
 Identities = 2813/2813 (100%), Positives = 2813/2813 (100%)

Query: 1    MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
            MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP
Sbjct: 1    MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60

Query: 61   GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
            GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD
Sbjct: 61   GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120

Query: 121  QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
            QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
Sbjct: 121  QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180

Query: 181  WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
            WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG
Sbjct: 181  WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240

Query: 241  DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL 300
            DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL
Sbjct: 241  DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL 300

Query: 301  MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV 360
            MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
Sbjct: 301  MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV 360

Query: 361  EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN 420
            EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN
Sbjct: 361  EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN 420

Query: 421  RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG 480
            RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG
Sbjct: 421  RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG 480

Query: 481  EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA 540
            EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
Sbjct: 481  EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA 540

Query: 541  SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG 600
            SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG
Sbjct: 541  SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG 600

Query: 601  LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK 660
            LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK
Sbjct: 601  LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK 660

Query: 661  LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD 720
            LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
Sbjct: 661  LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD 720

Query: 721  PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI 780
            PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI
Sbjct: 721  PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI 780

Query: 781  SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL 840
            SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL
Sbjct: 781  SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL 840

Query: 841  EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA 900
            EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
Sbjct: 841  EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA 900

Query: 901  TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT 960
            TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT
Sbjct: 901  TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT 960

Query: 961  QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP 1020
            QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP
Sbjct: 961  QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP 1020

Query: 1021 GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA 1080
            GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
Sbjct: 1021 GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA 1080

Query: 1081 CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA 1140
            CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA
Sbjct: 1081 CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA 1140

Query: 1141 VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME 1200
            VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME
Sbjct: 1141 VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME 1200

Query: 1201 LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI 1260
            LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
Sbjct: 1201 LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI 1260

Query: 1261 EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG 1320
            EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG
Sbjct: 1261 EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG 1320

Query: 1321 SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK 1380
            SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK
Sbjct: 1321 SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK 1380

Query: 1381 QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD 1440
            QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD
Sbjct: 1381 QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD 1440

Query: 1441 SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN 1500
            SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN
Sbjct: 1441 SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN 1500

Query: 1501 RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP 1560
            RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP
Sbjct: 1501 RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP 1560

Query: 1561 FRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKPSSSL 1620
            FRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKPSSSL
Sbjct: 1561 FRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKPSSSL 1620

Query: 1621 EVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSA 1680
            EVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSA
Sbjct: 1621 EVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSA 1680

Query: 1681 ISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWK 1740
            ISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWK
Sbjct: 1681 ISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWK 1740

Query: 1741 SGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVV 1800
            SGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVV
Sbjct: 1741 SGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVV 1800

Query: 1801 GPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPT 1860
            GPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPT
Sbjct: 1801 GPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPT 1860

Query: 1861 VIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMS 1920
            VIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMS
Sbjct: 1861 VIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMS 1920

Query: 1921 NTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRII 1980
            NTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRII
Sbjct: 1921 NTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRII 1980

Query: 1981 DSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFP 2040
            DSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFP
Sbjct: 1981 DSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFP 2040

Query: 2041 CLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKF 2100
            CLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKF
Sbjct: 2041 CLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKF 2100

Query: 2101 CGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRI 2160
            CGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRI
Sbjct: 2101 CGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRI 2160

Query: 2161 LQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQ 2220
            LQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQ
Sbjct: 2161 LQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQ 2220

Query: 2221 MFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTV 2280
            MFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTV
Sbjct: 2221 MFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTV 2280

Query: 2281 ISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDED 2340
            ISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDED
Sbjct: 2281 ISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDED 2340

Query: 2341 EGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPT 2400
            EGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPT
Sbjct: 2341 EGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPT 2400

Query: 2401 HSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVS 2460
            HSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVS
Sbjct: 2401 HSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVS 2460

Query: 2461 LPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQ 2520
            LPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQ
Sbjct: 2461 LPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQ 2520

Query: 2521 VVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQ 2580
            VVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQ
Sbjct: 2521 VVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQ 2580

Query: 2581 RQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREEL 2640
            RQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREEL
Sbjct: 2581 RQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREEL 2640

Query: 2641 QQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSF 2700
            QQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSF
Sbjct: 2641 QQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSF 2700

Query: 2701 FPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQ 2760
            FPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQ
Sbjct: 2701 FPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQ 2760

Query: 2761 SQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2813
            SQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 2761 SQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2813


>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
          Length = 2817

 Score = 5520 bits (14319), Expect = 0.0
 Identities = 2798/2817 (99%), Positives = 2800/2817 (99%), Gaps = 4/2817 (0%)

Query: 1    MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
            MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP
Sbjct: 1    MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60

Query: 61   GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
            GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD
Sbjct: 61   GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120

Query: 121  QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
            QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT
Sbjct: 121  QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180

Query: 181  WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
            WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG
Sbjct: 181  WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240

Query: 241  DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL 300
            DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL
Sbjct: 241  DCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPL 300

Query: 301  MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV 360
            MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV
Sbjct: 301  MMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIV 360

Query: 361  EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN 420
            EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN
Sbjct: 361  EEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGN 420

Query: 421  RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG 480
            RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG
Sbjct: 421  RNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAG 480

Query: 481  EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA 540
            EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA
Sbjct: 481  EMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAA 540

Query: 541  SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG 600
            SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG
Sbjct: 541  SSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDG 600

Query: 601  LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK 660
            LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK
Sbjct: 601  LEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDK 660

Query: 661  LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD 720
            LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD
Sbjct: 661  LCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSD 720

Query: 721  PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI 780
            PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI
Sbjct: 721  PVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVI 780

Query: 781  SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL 840
            SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL
Sbjct: 781  SDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPL 840

Query: 841  EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA 900
            EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA
Sbjct: 841  EDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKA 900

Query: 901  TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT 960
            TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT
Sbjct: 901  TLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDT 960

Query: 961  QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP 1020
            QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP
Sbjct: 961  QQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPP 1020

Query: 1021 GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA 1080
            GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA
Sbjct: 1021 GASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSA 1080

Query: 1081 CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA 1140
            CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA
Sbjct: 1081 CEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKA 1140

Query: 1141 VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME 1200
            VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME
Sbjct: 1141 VTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDME 1200

Query: 1201 LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI 1260
            LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI
Sbjct: 1201 LSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVI 1260

Query: 1261 EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG 1320
            EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG
Sbjct: 1261 EQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATG 1320

Query: 1321 SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK 1380
            SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK
Sbjct: 1321 SLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMK 1380

Query: 1381 QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD 1440
            QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD
Sbjct: 1381 QGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSD 1440

Query: 1441 SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN 1500
            SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN
Sbjct: 1441 SDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPN 1500

Query: 1501 RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP 1560
            RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP
Sbjct: 1501 RSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSP 1560

Query: 1561 FRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPI----HRRSFSLEGLTGGAGVGNKP 1616
            FRRHSWGPGKNAASDAEMNHRS       V     +    + RSFSLEGLTGGAGVGNKP
Sbjct: 1561 FRRHSWGPGKNAASDAEMNHRSMSWCPSGVQYSAGLSADFNYRSFSLEGLTGGAGVGNKP 1620

Query: 1617 SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY 1676
            SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY
Sbjct: 1621 SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY 1680

Query: 1677 CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD 1736
            CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD
Sbjct: 1681 CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD 1740

Query: 1737 SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS 1796
            SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS
Sbjct: 1741 SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSS 1800

Query: 1797 IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS 1856
            IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS
Sbjct: 1801 IPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTS 1860

Query: 1857 SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND 1916
            SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND
Sbjct: 1861 SLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGND 1920

Query: 1917 ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW 1976
            ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW
Sbjct: 1921 ENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESW 1980

Query: 1977 SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE 2036
            SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE
Sbjct: 1981 SRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVE 2040

Query: 2037 KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT 2096
            KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT
Sbjct: 2041 KLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKT 2100

Query: 2097 YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL 2156
            YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL
Sbjct: 2101 YGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVL 2160

Query: 2157 FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM 2216
            FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM
Sbjct: 2161 FQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRM 2220

Query: 2217 KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ 2276
            KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ
Sbjct: 2221 KSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQ 2280

Query: 2277 KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN 2336
            KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN
Sbjct: 2281 KSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLN 2340

Query: 2337 RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED 2396
            RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED
Sbjct: 2341 RDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED 2400

Query: 2397 CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV 2456
            CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV
Sbjct: 2401 CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVV 2460

Query: 2457 GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR 2516
            GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR
Sbjct: 2461 GPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKR 2520

Query: 2517 NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS 2576
            NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS
Sbjct: 2521 NSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRS 2580

Query: 2577 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2636
            LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE
Sbjct: 2581 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2640

Query: 2637 REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR 2696
            REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR
Sbjct: 2641 REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMR 2700

Query: 2697 IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG 2756
            IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG
Sbjct: 2701 IPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKG 2760

Query: 2757 PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2813
            PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 2761 PEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2817


>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
          Length = 1058

 Score = 2061 bits (5339), Expect = 0.0
 Identities = 1058/1058 (100%), Positives = 1058/1058 (100%)

Query: 1756 MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 1815
            MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK
Sbjct: 1    MSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNK 60

Query: 1816 DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 1875
            DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR
Sbjct: 61   DAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPR 120

Query: 1876 SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 1935
            SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK
Sbjct: 121  SAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNK 180

Query: 1936 ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 1995
            ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR
Sbjct: 181  ISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKR 240

Query: 1996 QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 2055
            QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR
Sbjct: 241  QEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQR 300

Query: 2056 ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 2115
            ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY
Sbjct: 301  ILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLY 360

Query: 2116 AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 2175
            AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA
Sbjct: 361  AKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLA 420

Query: 2176 QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 2235
            QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD
Sbjct: 421  QSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRD 480

Query: 2236 GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 2295
            GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE
Sbjct: 481  GSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEE 540

Query: 2296 KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 2355
            KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD
Sbjct: 541  KGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLD 600

Query: 2356 TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 2415
            TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL
Sbjct: 601  TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEAL 660

Query: 2416 KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 2475
            KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ
Sbjct: 661  KGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQ 720

Query: 2476 MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 2535
            MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL
Sbjct: 721  MNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSAL 780

Query: 2536 QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 2595
            QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL
Sbjct: 781  QGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYL 840

Query: 2596 EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 2655
            EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR
Sbjct: 841  EEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLR 900

Query: 2656 AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 2715
            AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI
Sbjct: 901  AAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSI 960

Query: 2716 AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 2775
            AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG
Sbjct: 961  AKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFG 1020

Query: 2776 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 2813
            LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
Sbjct: 1021 LTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC 1058


>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
            [Homo sapiens]
          Length = 1173

 Score =  597 bits (1540), Expect = e-170
 Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)

Query: 1916 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 1975
            DE  S   KF   + DSL   S  + +TES+  E    D     L  + E +  + EAES
Sbjct: 188  DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 240

Query: 1976 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 2035
            WS  +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM  VYS+ +  +L F  + +
Sbjct: 241  WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300

Query: 2036 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 2095
             +LFPC D+L+  HS F  R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 301  GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360

Query: 2096 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 2155
             YG FC  HN++V+++K L  ++K+FQ  +KK  + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 361  KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420

Query: 2156 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 2215
            L +RI+Q T+    + EDL Q+L+L+KD+I  VD+KV+  EK  RL EI  K D KS  +
Sbjct: 421  LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480

Query: 2216 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 2275
            +K+G  F KED+ +++L  +G +  K  +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 481  LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540

Query: 2276 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335
             K  VISL+KLIVREVA+EEK +FLIS  +  PEM E++ SSKE+RN+W+  IQ  + + 
Sbjct: 541  SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600

Query: 2336 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 2390
              DE+EG  S  EEE+K+++   TR R+ +E+L  KDQ I   L EK+ I+ +MAE    
Sbjct: 601  -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 659

Query: 2391 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 2449
              LP+       PR LFR  +  E L+G  ++KSA++E+E +Q L+   LG   G     
Sbjct: 660  EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 709

Query: 2450 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 2496
               +D       PRRAETF G+D        G  K++               +  DL+ +
Sbjct: 710  ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 766

Query: 2497 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 2547
            +SD       +  +V      S+         ++VQ +  L +LL  LQ V+  QDSY+E
Sbjct: 767  DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 826

Query: 2548 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 2605
             Q+  + ER     L  +R + L+EQE+QR+ EKQR++ A L+K Q+Q   E++R ERE 
Sbjct: 827  TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 886

Query: 2606 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 2665
            + + +EL    A L +RE E +Q ++ LE+ER EL++++  YQ+DLERLR AQ+ +ERE+
Sbjct: 887  QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 946

Query: 2666 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 2711
            E+L     RL ++ T           +    SHP   + + +  P  S  PS   P    
Sbjct: 947  ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 1005

Query: 2712 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 2771
             P +A+  S  +E          +R  K   P  +LS+T+Q  +    Q Q P   +AST
Sbjct: 1006 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 1055

Query: 2772 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 2802
                      K  K K  K+  SQ  +  AS
Sbjct: 1056 ----------KGGKDKGGKSRGSQRWESSAS 1076


>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
            [Homo sapiens]
          Length = 1015

 Score =  597 bits (1540), Expect = e-170
 Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)

Query: 1916 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 1975
            DE  S   KF   + DSL   S  + +TES+  E    D     L  + E +  + EAES
Sbjct: 30   DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 82

Query: 1976 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 2035
            WS  +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM  VYS+ +  +L F  + +
Sbjct: 83   WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 142

Query: 2036 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 2095
             +LFPC D+L+  HS F  R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 143  GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 202

Query: 2096 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 2155
             YG FC  HN++V+++K L  ++K+FQ  +KK  + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 203  KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 262

Query: 2156 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 2215
            L +RI+Q T+    + EDL Q+L+L+KD+I  VD+KV+  EK  RL EI  K D KS  +
Sbjct: 263  LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 322

Query: 2216 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 2275
            +K+G  F KED+ +++L  +G +  K  +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 323  LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 382

Query: 2276 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335
             K  VISL+KLIVREVA+EEK +FLIS  +  PEM E++ SSKE+RN+W+  IQ  + + 
Sbjct: 383  SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 442

Query: 2336 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 2390
              DE+EG  S  EEE+K+++   TR R+ +E+L  KDQ I   L EK+ I+ +MAE    
Sbjct: 443  -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 501

Query: 2391 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 2449
              LP+       PR LFR  +  E L+G  ++KSA++E+E +Q L+   LG   G     
Sbjct: 502  EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 551

Query: 2450 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 2496
               +D       PRRAETF G+D        G  K++               +  DL+ +
Sbjct: 552  ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 608

Query: 2497 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 2547
            +SD       +  +V      S+         ++VQ +  L +LL  LQ V+  QDSY+E
Sbjct: 609  DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 668

Query: 2548 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 2605
             Q+  + ER     L  +R + L+EQE+QR+ EKQR++ A L+K Q+Q   E++R ERE 
Sbjct: 669  TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 728

Query: 2606 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 2665
            + + +EL    A L +RE E +Q ++ LE+ER EL++++  YQ+DLERLR AQ+ +ERE+
Sbjct: 729  QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 788

Query: 2666 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 2711
            E+L     RL ++ T           +    SHP   + + +  P  S  PS   P    
Sbjct: 789  ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 847

Query: 2712 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 2771
             P +A+  S  +E          +R  K   P  +LS+T+Q  +    Q Q P   +AST
Sbjct: 848  RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 897

Query: 2772 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 2802
                      K  K K  K+  SQ  +  AS
Sbjct: 898  ----------KGGKDKGGKSRGSQRWESSAS 918


>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
          Length = 1651

 Score =  588 bits (1517), Expect = e-167
 Identities = 390/1120 (34%), Positives = 610/1120 (54%), Gaps = 103/1120 (9%)

Query: 1596 IHRRSFSLEGLTGGA-GVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESD 1654
            + +RS SL+ L   + G G+   S +  +  +    R      + +DS  + +E D    
Sbjct: 472  LKKRSSSLDALDADSEGEGHSEPSHICYTPGSQSSSRTGIPSGDELDSFETNTEPDFNIS 531

Query: 1655 QREHRMFDQQICHRS------KQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHST 1708
            + E       +  +       + + ++  +  IS   T+ +  +T+      +S      
Sbjct: 532  RAESLPLSSNLQSKESLLSGVRSRSYSCSSPKISLGKTRLVRELTVC-----SSSEEQRA 586

Query: 1709 FHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKE 1768
            +  +       I EE ++     P+K +SE     KVSRTFS++ N+M+S +        
Sbjct: 587  YSLSEPPRENRIQEEEWDKYI-IPAKSESE---KYKVSRTFSFLMNRMTSPR-------- 634

Query: 1769 KDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVH 1828
             +K K K KD+KDKEK    +N H F+     G + C  C K    K++  C+NC+A VH
Sbjct: 635  -NKSKTKSKDAKDKEK----LNRHQFAPGTFSGVLQCLVCDKTLLGKESLQCSNCNANVH 689

Query: 1829 KGCRESLASCAKVKMKQ------------------PKGSLQAHDTSSLPTVIMRNKPSQP 1870
            KGC+++  +C K   ++                  P+  L  H +SS+P  +    P+  
Sbjct: 690  KGCKDAAPACTKKFQEKYNKNKPQTILGNSSFRDIPQPGLSLHPSSSVPVGL----PTGR 745

Query: 1871 KERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHST 1930
            +E       L      T + + RRS  S+                 E+  N+ +  SHS 
Sbjct: 746  RETVGQVHPLSRSVPGTTLESFRRSATSLE---------------SESDHNSCRSRSHSD 790

Query: 1931 DSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKK 1990
            + L  +   + STES   E    D+ +  L  D   ++++ EAESWS ++D  F  +Q+K
Sbjct: 791  ELLQSMGS-SPSTESFIME----DVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEK 845

Query: 1991 DVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHS 2050
            DV+KRQ+VI+ELMQTE HH++TL IMS ++ +GM  +L  +   V+K+FPCLDEL+ IH 
Sbjct: 846  DVIKRQDVIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHR 905

Query: 2051 QFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNY 2110
             FF  + ER++ES    S++NF+I RIGD+LV QFS ENA ++KK YG+FC  H ++VN 
Sbjct: 906  HFFYSMKERRQESCAG-SDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNL 964

Query: 2111 FKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVE 2170
            FK+L  ++K+FQ F+K + S+ + RR GIPECILLVTQRITKYPVL +RILQ TK+   E
Sbjct: 965  FKELQ-QNKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEE 1023

Query: 2171 QEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDL--K 2228
             +DL ++L L+KD+I  VD KV  YEK  +  EI  K ++K+  ++K+G +F K+ L  +
Sbjct: 1024 HKDLRKALCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSE 1083

Query: 2229 RKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIV 2288
             + L+ DG V+ K A GR K++ A+LLTD+L+FLQEKDQKYIFA++DQK +VISL+KLI 
Sbjct: 1084 ERTLLYDGLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIA 1143

Query: 2289 REVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENE 2348
            REVA+EE+G+FLIS     PEM E+H +SKEERN+W++ IQ  + +   +E  G  SE++
Sbjct: 1144 REVANEERGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESC-PEEKGGRTSESD 1202

Query: 2349 EEKKMLDTRA---RELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTH-SPR 2404
            E+K+  + R    ++ +E L  +DQ+I   LEEK  I+ ++ E S          H  P 
Sbjct: 1203 EDKRKAEARVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELS-----GFEDVHLEPH 1257

Query: 2405 VLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRR 2464
            +L + +  E  +   L+ +A+ E E LQ  V  +  G +  +        V+        
Sbjct: 1258 LLIKPDPGEPPQAASLLAAALKEAESLQVAVKASQMGAVSQSCEDSCGDSVL-------- 1309

Query: 2465 AETFGGFD---SHQMNASKGGEKEEG--DDGQDLRRTESDSGLKKGGNANLVFMLKRNSE 2519
            A+T    D   S   +   GG +  G  D    ++   +D  +   G          +S+
Sbjct: 1310 ADTLSSHDVPGSPTASLVTGGREGRGCSDVDPGIQGVVTDLAVSDAGEKVECRNFPGSSQ 1369

Query: 2520 -QVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER---ALTRSLSRPSSLIEQEKQR 2575
             +++Q++ +L  LL +LQ  +  QDS+IE  +LVL ++   +L  S+ R   L + +K R
Sbjct: 1370 SEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPL-QDQKSR 1428

Query: 2576 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 2635
              ++Q ++LAN+ + Q Q  +E+RR  R  E ++R    RE+ L +RE E Q  ++ L +
Sbjct: 1429 DADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLLR 1488

Query: 2636 EREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERL 2675
             R EL  +   YQ+ LERLR  Q+ +EREQ ++R +   L
Sbjct: 1489 SRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLL 1528



 Score =  141 bits (356), Expect = 8e-33
 Identities = 87/263 (33%), Positives = 133/263 (50%), Gaps = 4/263 (1%)

Query: 1   MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAP 60
           M+L+  +APLYG  ++     +     +D  FY  + GS  RH     ++  + L++  P
Sbjct: 1   MELSCSEAPLYGQMMIYAKFDKNVYLPEDAEFYFTYDGSHQRHVMIAERIEDNVLQSSVP 60

Query: 61  GHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLD 120
           GH   ETV V +C   EG     +      +V + A   A+ L T A    A +    L 
Sbjct: 61  GHGLQETVTVSVCLCSEGYSPVTMGSGSVTYVDNMACRLARLLVTQANRLTACSHQTLLT 120

Query: 121 QSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLT 180
                +G + +LD++LVLA  HL+LP EW VLG+  SL  +  RE+L+H A+R GL +L+
Sbjct: 121 PFALTAGALPALDEELVLALTHLELPLEWTVLGS-SSLEVSSHRESLLHLAMRWGLAKLS 179

Query: 181 WFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYG 240
            F L  PGG  AL++ N+EGATP+ LAL  G+ KL + +T        S+S +       
Sbjct: 180 QFFLCLPGGVQALALPNEEGATPLDLALREGHSKLVEDVTNFQGRWSPSFSRVQLS---E 236

Query: 241 DCSVRHHRELDIYTLTSESDSHH 263
           + S+ +    +  TLT    + H
Sbjct: 237 EASLHYIHSSETLTLTLNHTAEH 259


>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
            [Homo sapiens]
          Length = 986

 Score =  585 bits (1508), Expect = e-166
 Identities = 371/908 (40%), Positives = 550/908 (60%), Gaps = 58/908 (6%)

Query: 1745 VSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPIS 1804
            +SR  S  + ++  S++   K +EK+K+KE         KD +  NGH F++I V G   
Sbjct: 1    MSRIESLTRARIDRSRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTM 52

Query: 1805 CSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMR 1864
            C  C K  T K+A  C  C+  +H  C+++LA+C KVK KQ K +L  ++T+ L +V +R
Sbjct: 53   CYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLR 111

Query: 1865 NKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK 1924
            +K +  +ERP SA+   D    + +  +RR + S+SL+KSVS  NI G  NDE+     +
Sbjct: 112  SKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRR 169

Query: 1925 FLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKF 1984
             LS STDSLN  ++   S ESL DE    ++   +L+ DFE++ K   A+SWS  +DS F
Sbjct: 170  ILSQSTDSLNMRNRTL-SVESLIDEA---EVIYSELMSDFEMDEKDFAADSWSLAVDSSF 225

Query: 1985 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2044
            L+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++  GM+ +L  E  +V+ LFPC+DE
Sbjct: 226  LQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDE 285

Query: 2045 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2104
            L  IH++F  ++LER++++L   S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H
Sbjct: 286  LSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRH 345

Query: 2105 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2164
            ++++  +K+LYA+DKRFQ F++K    +V++R G+ ECILLVTQRITKYP+L  RILQ +
Sbjct: 346  SKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHS 405

Query: 2165 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK 2224
               E E++DL  +L LVK+++  VD  +   EK  RL EIY + D ++   +     F +
Sbjct: 406  HGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGR 465

Query: 2225 EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLK 2284
            E+L R+KL+ DG +  K A GR K+V  +L+TD+LVFLQEKDQKYIF +LD K +V+SL+
Sbjct: 466  EELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQ 524

Query: 2285 KLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIP 2344
             LIVR++A++EKG+FLIS     PEM EVH +S+++R++WI++IQ ++ T    ED  + 
Sbjct: 525  NLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL- 581

Query: 2345 SENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSP 2399
             E E+E  +     R +K +L QKD+ ++ LL EK  +F +M        ED       P
Sbjct: 582  IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALP 634

Query: 2400 THSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPV 2459
            T  PR LFRS + E+ +G  L++ AI EVE L+ L+ G  G  L  T   P         
Sbjct: 635  T-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP--------- 683

Query: 2460 SLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNS 2518
            +LP   ++ GG  S  + A+  GE    +   +L R +SDS  + + GN      L+   
Sbjct: 684  ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQ 735

Query: 2519 EQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQR 2575
            E+ +Q +V+LY LL  LQ  V QQD+ +E +     ER   L R+ SR            
Sbjct: 736  EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPV 795

Query: 2576 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 2635
            + EKQ  +LA LQ+Q A   EE RR  R  E R  E    EA    R  E +Q +  LE+
Sbjct: 796  APEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLER 851

Query: 2636 EREELQQK 2643
            E EE +++
Sbjct: 852  EAEEARRQ 859


>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
            [Homo sapiens]
          Length = 985

 Score =  585 bits (1507), Expect = e-166
 Identities = 371/908 (40%), Positives = 550/908 (60%), Gaps = 59/908 (6%)

Query: 1745 VSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPIS 1804
            +SR  S  + ++  S++   K +EK+K+KE         KD +  NGH F++I V G   
Sbjct: 1    MSRIESLTRARIDRSRELASKTREKEKMKEA--------KDARYTNGHLFTTISVSGMTM 52

Query: 1805 CSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMR 1864
            C  C K  T K+A  C  C+  +H  C+++LA+C KVK KQ K +L  ++T+ L +V +R
Sbjct: 53   CYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQKQQKAALLKNNTA-LQSVSLR 111

Query: 1865 NKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWK 1924
            +K +  +ERP SA+   D    + +  +RR + S+SL+KSVS  NI G  NDE+     +
Sbjct: 112  SKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAKSVSTTNIAGHFNDESPLGLRR 169

Query: 1925 FLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKF 1984
             LS STDSLN  ++   S ESL DE    ++   +L+ DFE++ K   A+SWS  +DS F
Sbjct: 170  ILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSDFEMDEKDFAADSWSLAVDSSF 224

Query: 1985 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2044
            L+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++  GM+ +L  E  +V+ LFPC+DE
Sbjct: 225  LQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVVQGLFPCVDE 284

Query: 2045 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2104
            L  IH++F  ++LER++++L   S +NF+I R+GD+L++QFSG +AE++ KTY +FC +H
Sbjct: 285  LSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCKTYSEFCSRH 344

Query: 2105 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2164
            ++++  +K+LYA+DKRFQ F++K    +V++R G+ ECILLVTQRITKYP+L  RILQ +
Sbjct: 345  SKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPLLISRILQHS 404

Query: 2165 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAK 2224
               E E++DL  +L LVK+++  VD  +   EK  RL EIY + D ++   +     F +
Sbjct: 405  HGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTPVPGKGPFGR 464

Query: 2225 EDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLK 2284
            E+L R+KL+ DG +  K A GR K+V  +L+TD+LVFLQEKDQKYIF +LD K +V+SL+
Sbjct: 465  EELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD-KPSVVSLQ 523

Query: 2285 KLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIP 2344
             LIVR++A++EKG+FLIS     PEM EVH +S+++R++WI++IQ ++ T    ED  + 
Sbjct: 524  NLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRSTWIRVIQQSVRTCPSREDFPL- 580

Query: 2345 SENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPED-----CSP 2399
             E E+E  +     R +K +L QKD+ ++ LL EK  +F +M        ED       P
Sbjct: 581  IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLFAEMTHFQA--EEDGGSGMALP 633

Query: 2400 THSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPV 2459
            T  PR LFRS + E+ +G  L++ AI EVE L+ L+ G  G  L  T   P         
Sbjct: 634  T-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP-GVELLLTPREP--------- 682

Query: 2460 SLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLK-KGGNANLVFMLKRNS 2518
            +LP   ++ GG  S  + A+  GE    +   +L R +SDS  + + GN      L+   
Sbjct: 683  ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADSDSSQRDRNGN-----QLRSPQ 734

Query: 2519 EQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER--ALTRSLSRPSSLIEQ-EKQR 2575
            E+ +Q +V+LY LL  LQ  V QQD+ +E +     ER   L R+ SR            
Sbjct: 735  EEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERREKLCRANSRDGEAGRAGAAPV 794

Query: 2576 SLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEK 2635
            + EKQ  +LA LQ+Q A   EE RR  R  E R  E    EA    R  E +Q +  LE+
Sbjct: 795  APEKQATELALLQRQHALLQEELRRCRRLGEERATEAGSLEA----RLRESEQARALLER 850

Query: 2636 EREELQQK 2643
            E EE +++
Sbjct: 851  EAEEARRQ 858


>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
            [Homo sapiens]
          Length = 958

 Score =  574 bits (1479), Expect = e-163
 Identities = 361/869 (41%), Positives = 531/869 (61%), Gaps = 51/869 (5%)

Query: 1784 KDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKM 1843
            KD +  NGH F++I V G   C  C K  T K+A  C  C+  +H  C+++LA+C KVK 
Sbjct: 5    KDARYTNGHLFTTISVSGMTMCYACNKSITAKEALICPTCNVTIHNRCKDTLANCTKVKQ 64

Query: 1844 KQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSK 1903
            KQ K +L  ++T+ L +V +R+K +  +ERP SA+   D    + +  +RR + S+SL+K
Sbjct: 65   KQQKAALLKNNTA-LQSVSLRSKTTI-RERPSSAIYPSDSFRQS-LLGSRRGRSSLSLAK 121

Query: 1904 SVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGD 1963
            SVS  NI G  NDE+     + LS STDSLN  ++   S ESL DE    ++   +L+ D
Sbjct: 122  SVSTTNIAGHFNDESPLGLRRILSQSTDSLNMRNRTL-SVESLIDE----EVIYSELMSD 176

Query: 1964 FEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQG 2023
            FE++ K   A+SWS  +DS FL+Q KK+V+K+Q+VIYEL+QTE HHVRTLKIM+ ++  G
Sbjct: 177  FEMDEKDFAADSWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTG 236

Query: 2024 MMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN 2083
            M+ +L  E  +V+ LFPC+DEL  IH++F  ++LER++++L   S +NF+I R+GD+L++
Sbjct: 237  MLEELHLEPGVVQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLIS 296

Query: 2084 QFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECI 2143
            QFSG +AE++ KTY +FC +H++++  +K+LYA+DKRFQ F++K    +V++R G+ ECI
Sbjct: 297  QFSGPSAEQMCKTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECI 356

Query: 2144 LLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNE 2203
            LLVTQRITKYP+L  RILQ +   E E++DL  +L LVK+++  VD  +   EK  RL E
Sbjct: 357  LLVTQRITKYPLLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQE 416

Query: 2204 IYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ 2263
            IY + D ++   +     F +E+L R+KL+ DG +  K A GR K+V  +L+TD+LVFLQ
Sbjct: 417  IYNRMDPRAQTPVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQ 476

Query: 2264 EKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNS 2323
            EKDQKYIF +LD K +V+SL+ LIVR++A++EKG+FLIS     PEM EVH +S+++R++
Sbjct: 477  EKDQKYIFPTLD-KPSVVSLQNLIVRDIANQEKGMFLIS--AAPPEMYEVHTASRDDRST 533

Query: 2324 WIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIF 2383
            WI++IQ ++ T    ED  +  E E+E  +     R +K +L QKD+ ++ LL EK  +F
Sbjct: 534  WIRVIQQSVRTCPSREDFPL-IETEDEAYL-----RRIKMELQQKDRALVELLREKVGLF 587

Query: 2384 RDMAECSTPLPED-----CSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGN 2438
             +M        ED       PT  PR LFRS + E+ +G  L++ AI EVE L+ L+ G 
Sbjct: 588  AEMTHFQA--EEDGGSGMALPT-LPRGLFRSESLESPRGERLLQDAIREVEGLKDLLVGP 644

Query: 2439 LGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTES 2498
             G  L  T   P         +LP   ++ GG  S  + A+  GE    +   +L R +S
Sbjct: 645  -GVELLLTPREP---------ALPLEPDS-GGNTSPGVTAN--GEARTFNGSIELCRADS 691

Query: 2499 DSGLK-KGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSER- 2556
            DS  + + GN      L+   E+ +Q +V+LY LL  LQ  V QQD+ +E +     ER 
Sbjct: 692  DSSQRDRNGN-----QLRSPQEEALQRLVNLYGLLHGLQAAVAQQDTLMEARFPEGPERR 746

Query: 2557 -ALTRSLSRPSSLIEQ-EKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELRE 2614
              L R+ SR            + EKQ  +LA LQ+Q A   EE RR  R  E R  E   
Sbjct: 747  EKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRRLGEERATEAGS 806

Query: 2615 REALLAQREEEVQQGQQDLEKEREELQQK 2643
             EA    R  E +Q +  LE+E EE +++
Sbjct: 807  LEA----RLRESEQARALLEREAEEARRQ 831


>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
            sapiens]
          Length = 927

 Score =  189 bits (480), Expect = 3e-47
 Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)

Query: 1947 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2003
            TDEG  T+  E    G+      +LE E    W  ++    L    K  VKRQEVI EL+
Sbjct: 381  TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 440

Query: 2004 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2063
             TE  HVR L+++  ++ Q M   L F  + ++ +FP LDELI +HS F  R+++R++ES
Sbjct: 441  VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 500

Query: 2064 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2123
                    +LI+ IGDVL+ +F G      +K   +FC + + ++   K    KD RF A
Sbjct: 501  -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 553

Query: 2124 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2183
            FV++  S    RRL + + I    QR+TKYP+L Q I Q T++   E+E +  +    ++
Sbjct: 554  FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 612

Query: 2184 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2240
            ++  V+  V   E  +RL +   + D  S +R  S  M   F   D+ +KKLV +G +  
Sbjct: 613  ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 671

Query: 2241 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2289
            +    +  EV  +LL D+L+ LQ +D++ +  S  +  T           V+ L   + R
Sbjct: 672  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 731

Query: 2290 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335
            EVA + K  +++     + ++ E+ A +  ER +W  +I +T  +L
Sbjct: 732  EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 777


>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
            sapiens]
          Length = 879

 Score =  189 bits (480), Expect = 3e-47
 Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)

Query: 1947 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2003
            TDEG  T+  E    G+      +LE E    W  ++    L    K  VKRQEVI EL+
Sbjct: 333  TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 392

Query: 2004 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2063
             TE  HVR L+++  ++ Q M   L F  + ++ +FP LDELI +HS F  R+++R++ES
Sbjct: 393  VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 452

Query: 2064 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2123
                    +LI+ IGDVL+ +F G      +K   +FC + + ++   K    KD RF A
Sbjct: 453  -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 505

Query: 2124 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2183
            FV++  S    RRL + + I    QR+TKYP+L Q I Q T++   E+E +  +    ++
Sbjct: 506  FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 564

Query: 2184 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2240
            ++  V+  V   E  +RL +   + D  S +R  S  M   F   D+ +KKLV +G +  
Sbjct: 565  ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 623

Query: 2241 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2289
            +    +  EV  +LL D+L+ LQ +D++ +  S  +  T           V+ L   + R
Sbjct: 624  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 683

Query: 2290 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335
            EVA + K  +++     + ++ E+ A +  ER +W  +I +T  +L
Sbjct: 684  EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 729


>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
            sapiens]
          Length = 912

 Score =  189 bits (480), Expect = 3e-47
 Identities = 127/406 (31%), Positives = 207/406 (50%), Gaps = 26/406 (6%)

Query: 1947 TDEGVGTDMNEGQLLGDFEIESKQLEAES---WSRIIDSKFLKQQKKDVVKRQEVIYELM 2003
            TDEG  T+  E    G+      +LE E    W  ++    L    K  VKRQEVI EL+
Sbjct: 366  TDEGAETESPEPGDEGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELL 425

Query: 2004 QTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2063
             TE  HVR L+++  ++ Q M   L F  + ++ +FP LDELI +HS F  R+++R++ES
Sbjct: 426  VTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQES 485

Query: 2064 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2123
                    +LI+ IGDVL+ +F G      +K   +FC + + ++   K    KD RF A
Sbjct: 486  -------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQLKAKQRKDPRFCA 538

Query: 2124 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2183
            FV++  S    RRL + + I    QR+TKYP+L Q I Q T++   E+E +  +    ++
Sbjct: 539  FVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEE-PTEREKVELAAECCRE 597

Query: 2184 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQM---FAKEDLKRKKLVRDGSVFL 2240
            ++  V+  V   E  +RL +   + D  S +R  S  M   F   D+ +KKLV +G +  
Sbjct: 598  ILHHVNQAVRDMEDLLRLKDYQRRLD-LSHLRQSSDPMLSEFKNLDITKKKLVHEGPLTW 656

Query: 2241 KNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKST-----------VISLKKLIVR 2289
            +    +  EV  +LL D+L+ LQ +D++ +  S  +  T           V+ L   + R
Sbjct: 657  RVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTR 716

Query: 2290 EVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335
            EVA + K  +++     + ++ E+ A +  ER +W  +I +T  +L
Sbjct: 717  EVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSL 762


>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
            [Homo sapiens]
          Length = 1562

 Score =  178 bits (451), Expect = 8e-44
 Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)

Query: 1759 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 1814
            +KKS   +KEKD +++K+++   K   K   +  +   IP+    V P +    ++ F N
Sbjct: 555  TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 614

Query: 1815 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 1868
               Y           +    +   ES +S +++++ + + SL+  +       + R++ +
Sbjct: 615  NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 667

Query: 1869 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 1928
            +   R RS V + D  A     A R  Q + S + S+S +++     +     T K    
Sbjct: 668  ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 718

Query: 1929 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 1988
            S +S      +   T++L    +  D+ +   L D E E    +A++W   +    +   
Sbjct: 719  SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 768

Query: 1989 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 2048
             +  + RQEVI EL  TE  H+RTL+++  ++ Q M  + L  ++ + +LFP L ELI I
Sbjct: 769  TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 828

Query: 2049 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 2108
            H+ + + + + ++E  +        IK I D+++ +F G   E L++   +FC   + ++
Sbjct: 829  HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 880

Query: 2109 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 2168
               K    K+ RFQ F+++  S    RRL + + I+   QR+TKYP+L + I++ T+   
Sbjct: 881  ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 940

Query: 2169 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 2226
             E E L ++    ++++  V+  V   E + RL     + D+ ++ R  +     F   D
Sbjct: 941  SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 1000

Query: 2227 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 2278
            L  +K++ +G +  + +  +  ++  +LL D+LV LQ++D+K +          S D K 
Sbjct: 1001 LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1060

Query: 2279 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 2334
            T   V+ L  +++R VA +++  F+I +  +  P++ E+ A +  ++N+W++++++ +  
Sbjct: 1061 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1120

Query: 2335 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 2363
              R                               D+ +    E E E+    T +++  +
Sbjct: 1121 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1180

Query: 2364 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 2422
              HQ    +LL   E+E    +      P P       +  +  R+    A  G   M+ 
Sbjct: 1181 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1236

Query: 2423 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 2465
               SA+ +VE L+ L+  +L  G T+    +   E D+    S+            P +A
Sbjct: 1237 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1296

Query: 2466 ETFGGFDSHQMNASKGGEKEEGDDG 2490
               G  D+ Q+   +G   E+ D G
Sbjct: 1297 PPGGEGDNTQLAGLEGERPEQEDMG 1321


>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
            [Homo sapiens]
          Length = 1522

 Score =  178 bits (451), Expect = 8e-44
 Identities = 183/805 (22%), Positives = 359/805 (44%), Gaps = 111/805 (13%)

Query: 1759 SKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPV----VGPISCSQCMKPFTN 1814
            +KKS   +KEKD +++K+++   K   K   +  +   IP+    V P +    ++ F N
Sbjct: 515  TKKSSNSKKEKDALEDKKRNPILKYIGKPKSSSQSTFHIPLSPVEVKPGNVRNIIQHFEN 574

Query: 1815 KDAYTCAN------CSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPS 1868
               Y           +    +   ES +S +++++ + + SL+  +       + R++ +
Sbjct: 575  NQQYDAPEPGTQRLSTGSFPEDLLESDSSRSEIRLGRSE-SLKGREE------MKRSRKA 627

Query: 1869 QPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSH 1928
            +   R RS V + D  A     A R  Q + S + S+S +++     +     T K    
Sbjct: 628  ENVPRSRSDVDM-DAAAE----ATRLHQSASSSTSSLSTRSL----ENPTPPFTPKMGRR 678

Query: 1929 STDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQ 1988
            S +S      +   T++L    +  D+ +   L D E E    +A++W   +    +   
Sbjct: 679  SIES----PSLGFCTDTLLPHLLEDDLGQ---LSDLEPEP---DAQNWQHTVGKDVVAGL 728

Query: 1989 KKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISI 2048
             +  + RQEVI EL  TE  H+RTL+++  ++ Q M  + L  ++ + +LFP L ELI I
Sbjct: 729  TQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEI 788

Query: 2049 HSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSV 2108
            H+ + + + + ++E  +        IK I D+++ +F G   E L++   +FC   + ++
Sbjct: 789  HNSWCEAMKKLREEGPI--------IKEISDLMLARFDGPAREELQQVAAQFCSYQSIAL 840

Query: 2109 NYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNE 2168
               K    K+ RFQ F+++  S    RRL + + I+   QR+TKYP+L + I++ T+   
Sbjct: 841  ELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGT 900

Query: 2169 VEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKS--GQMFAKED 2226
             E E L ++    ++++  V+  V   E + RL     + D+ ++ R  +     F   D
Sbjct: 901  SEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLD 960

Query: 2227 LKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIF--------ASLDQKS 2278
            L  +K++ +G +  + +  +  ++  +LL D+LV LQ++D+K +          S D K 
Sbjct: 961  LTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSKQ 1020

Query: 2279 T---VISLKKLIVREVAHEEKGLFLI-SMGMTDPEMVEVHASSKEERNSWIQIIQDTINT 2334
            T   V+ L  +++R VA +++  F+I +  +  P++ E+ A +  ++N+W++++++ +  
Sbjct: 1021 TFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEAVRN 1080

Query: 2335 LNR-------------------------------DEDEGIPSENEEEKKMLDTRARELKE 2363
              R                               D+ +    E E E+    T +++  +
Sbjct: 1081 ATRHPGAAPMPVHPPPPGPREPAQQGPTPSRVELDDSDVFHGEPEPEELPGGTGSQQRVQ 1140

Query: 2364 QLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMK- 2422
              HQ    +LL   E+E    +      P P       +  +  R+    A  G   M+ 
Sbjct: 1141 GKHQ----VLLEDPEQEGSAEEEELGVLPCPSTSLDGENRGIRTRNPIHLAFPGPLFMEG 1196

Query: 2423 ---SAINEVEILQGLVSGNL--GGTLGPTVSSPIEQDVVGPVSL------------PRRA 2465
               SA+ +VE L+ L+  +L  G T+    +   E D+    S+            P +A
Sbjct: 1197 LADSALEDVENLRHLILWSLLPGHTMETQAAQEPEDDLTPTPSVISVTSHPWDPGSPGQA 1256

Query: 2466 ETFGGFDSHQMNASKGGEKEEGDDG 2490
               G  D+ Q+   +G   E+ D G
Sbjct: 1257 PPGGEGDNTQLAGLEGERPEQEDMG 1281


>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
            sapiens]
          Length = 1544

 Score =  169 bits (427), Expect = 5e-41
 Identities = 124/463 (26%), Positives = 221/463 (47%), Gaps = 42/463 (9%)

Query: 1933 LNKISKVNESTESLTDEGVGTDMN--EGQLLGDFEIESKQLEAE------SWSRIIDSKF 1984
            L+++ +     E +T+ G        +    G+ + E +Q E +      +W +++  + 
Sbjct: 718  LDQVQEEECEVERVTEHGTPKPFRKFDSVAFGESQSEDEQFENDLETDPPNWQQLVSREV 777

Query: 1985 LKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDE 2044
            L   K   +KRQEVI EL  TE  HVRTLK++  V+ Q +  + +     + K+F  L++
Sbjct: 778  LLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPSELRKIFSNLED 837

Query: 2045 LISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQH 2104
            ++ +H    +++        V K  +  +I +IG+ L+  FSG   E+LK     FC   
Sbjct: 838  ILQLHIGLNEQM------KAVRKRNETSVIDQIGEDLLTWFSGPGEEKLKHAAATFCSNQ 891

Query: 2105 NQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCT 2164
              ++   K    KD RFQ FV+   S+ + RRL + + I    QR+TKYP+L   I + T
Sbjct: 892  PFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKYPLLLDNIAKYT 951

Query: 2165 KDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKS--IMRMKSGQMF 2222
             +   E+E + ++    + ++  V+  V   E K RL +   + D+ S  +    + +  
Sbjct: 952  -EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSLKLSEYPNVEEL 1010

Query: 2223 AKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKD--------QKYIFASL 2274
               DL ++K++ +G +  K    +  ++  +LL DILV LQ++D         K + ++ 
Sbjct: 1011 RNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTA 1070

Query: 2275 DQKST---VISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDT 2331
            D K T   VI L  ++VR+VA + K LF+ISM     ++ E+ A +  E+  W  +I   
Sbjct: 1071 DSKHTFSPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRM 1130

Query: 2332 INTLNRDEDEGIP--------SENEEEKKMLDTRARELKEQLH 2366
              ++     + IP         +N+EE         +LKE+ H
Sbjct: 1131 AASVKEQSTKPIPLPQSTPGEGDNDEED------PSKLKEEQH 1167


>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
            sapiens]
          Length = 532

 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)

Query: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027
            +K+ +++ WS   D    +      +KRQE I+EL Q E   +  LK+    Y   M+  
Sbjct: 102  TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 161

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087
             +  +Q + ++F  LD LI +H +   ++ + +K    D S ++     +G +LV     
Sbjct: 162  SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 212

Query: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147
                    +Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 213  -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 266

Query: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2206
             R+ KYP+L + IL+ T ++  +Q+ L +++++++ ++  +++K    E +  +   +Y 
Sbjct: 267  SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 326

Query: 2207 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2234
            +   K  +   S  +    +LK  + V+
Sbjct: 327  EEGQKDSLIDSSRVLCCHGELKNNRGVK 354


>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
            sapiens]
          Length = 558

 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)

Query: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027
            +K+ +++ WS   D    +      +KRQE I+EL Q E   +  LK+    Y   M+  
Sbjct: 128  TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 187

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087
             +  +Q + ++F  LD LI +H +   ++ + +K    D S ++     +G +LV     
Sbjct: 188  SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 238

Query: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147
                    +Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 239  -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 292

Query: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2206
             R+ KYP+L + IL+ T ++  +Q+ L +++++++ ++  +++K    E +  +   +Y 
Sbjct: 293  SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 352

Query: 2207 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2234
            +   K  +   S  +    +LK  + V+
Sbjct: 353  EEGQKDSLIDSSRVLCCHGELKNNRGVK 380


>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
            sapiens]
          Length = 526

 Score = 81.6 bits (200), Expect = 1e-14
 Identities = 58/268 (21%), Positives = 126/268 (47%), Gaps = 16/268 (5%)

Query: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027
            +K+ +++ WS   D    +      +KRQE I+EL Q E   +  LK+    Y   M+  
Sbjct: 96   TKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKL 155

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087
             +  +Q + ++F  LD LI +H +   ++ + +K    D S ++     +G +LV     
Sbjct: 156  SIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKP---DGSTEH-----VGPILVGWLP- 206

Query: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147
                    +Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 207  -----CLSSYDSYC-SNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPR 260

Query: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYE-KKVRLNEIYT 2206
             R+ KYP+L + IL+ T ++  +Q+ L +++++++ ++  +++K    E +  +   +Y 
Sbjct: 261  SRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYL 320

Query: 2207 KTDSKSIMRMKSGQMFAKEDLKRKKLVR 2234
            +   K  +   S  +    +LK  + V+
Sbjct: 321  EEGQKDSLIDSSRVLCCHGELKNNRGVK 348


>gi|38373682 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score = 78.6 bits (192), Expect = 8e-14
 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)

Query: 1974 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2027
            +SW  +ID   K  ++Q      +QE ++EL+ TE  ++R L+++  ++   ++    + 
Sbjct: 318  DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2086
            LL E +  E+LF  + E+  +H + +  ++      +++K+ +   + + GD L   +  
Sbjct: 374  LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428

Query: 2087 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2146
            G     L K Y ++C +    + Y + L   +  F+A++         +RL + + +   
Sbjct: 429  GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484

Query: 2147 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2206
             QR+TKYP+L + +L+ T++   ++  +A  +  V+  I  V++ +   +++ RL  + +
Sbjct: 485  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543

Query: 2207 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2250
            + D+  ++   S ++      F   DL          + ++L+ +GS+ +K       +V
Sbjct: 544  RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603

Query: 2251 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2308
               L TD+L+  +   +        +++ VI    L+ + V  E  + G FL+       
Sbjct: 604  YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656

Query: 2309 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2347
              V  +   AS +     W+  I                  Q  + +L  +EDE    E 
Sbjct: 657  SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716

Query: 2348 EEEKK 2352
            EEE++
Sbjct: 717  EEEEE 721


>gi|111154084 pleckstrin homology domain containing family G member 5
            isoform b [Homo sapiens]
          Length = 1083

 Score = 78.6 bits (192), Expect = 8e-14
 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)

Query: 1974 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2027
            +SW  +ID   K  ++Q      +QE ++EL+ TE  ++R L+++  ++   ++    + 
Sbjct: 395  DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 450

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2086
            LL E +  E+LF  + E+  +H + +  ++      +++K+ +   + + GD L   +  
Sbjct: 451  LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 505

Query: 2087 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2146
            G     L K Y ++C +    + Y + L   +  F+A++         +RL + + +   
Sbjct: 506  GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 561

Query: 2147 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2206
             QR+TKYP+L + +L+ T++   ++  +A  +  V+  I  V++ +   +++ RL  + +
Sbjct: 562  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 620

Query: 2207 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2250
            + D+  ++   S ++      F   DL          + ++L+ +GS+ +K       +V
Sbjct: 621  RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 680

Query: 2251 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2308
               L TD+L+  +   +        +++ VI    L+ + V  E  + G FL+       
Sbjct: 681  YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 733

Query: 2309 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2347
              V  +   AS +     W+  I                  Q  + +L  +EDE    E 
Sbjct: 734  SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 793

Query: 2348 EEEKK 2352
            EEE++
Sbjct: 794  EEEEE 798


>gi|111154088 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score = 78.6 bits (192), Expect = 8e-14
 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)

Query: 1974 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2027
            +SW  +ID   K  ++Q      +QE ++EL+ TE  ++R L+++  ++   ++    + 
Sbjct: 318  DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2086
            LL E +  E+LF  + E+  +H + +  ++      +++K+ +   + + GD L   +  
Sbjct: 374  LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428

Query: 2087 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2146
            G     L K Y ++C +    + Y + L   +  F+A++         +RL + + +   
Sbjct: 429  GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484

Query: 2147 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2206
             QR+TKYP+L + +L+ T++   ++  +A  +  V+  I  V++ +   +++ RL  + +
Sbjct: 485  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543

Query: 2207 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2250
            + D+  ++   S ++      F   DL          + ++L+ +GS+ +K       +V
Sbjct: 544  RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603

Query: 2251 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2308
               L TD+L+  +   +        +++ VI    L+ + V  E  + G FL+       
Sbjct: 604  YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656

Query: 2309 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2347
              V  +   AS +     W+  I                  Q  + +L  +EDE    E 
Sbjct: 657  SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716

Query: 2348 EEEKK 2352
            EEE++
Sbjct: 717  EEEEE 721


>gi|111154080 pleckstrin homology domain containing family G member 5
            isoform a [Homo sapiens]
          Length = 1006

 Score = 78.6 bits (192), Expect = 8e-14
 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)

Query: 1974 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2027
            +SW  +ID   K  ++Q      +QE ++EL+ TE  ++R L+++  ++   ++    + 
Sbjct: 318  DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 373

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2086
            LL E +  E+LF  + E+  +H + +  ++      +++K+ +   + + GD L   +  
Sbjct: 374  LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 428

Query: 2087 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2146
            G     L K Y ++C +    + Y + L   +  F+A++         +RL + + +   
Sbjct: 429  GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 484

Query: 2147 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2206
             QR+TKYP+L + +L+ T++   ++  +A  +  V+  I  V++ +   +++ RL  + +
Sbjct: 485  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 543

Query: 2207 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2250
            + D+  ++   S ++      F   DL          + ++L+ +GS+ +K       +V
Sbjct: 544  RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 603

Query: 2251 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2308
               L TD+L+  +   +        +++ VI    L+ + V  E  + G FL+       
Sbjct: 604  YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 656

Query: 2309 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2347
              V  +   AS +     W+  I                  Q  + +L  +EDE    E 
Sbjct: 657  SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 716

Query: 2348 EEEKK 2352
            EEE++
Sbjct: 717  EEEEE 721


>gi|111154078 pleckstrin homology domain containing family G member 5
            isoform c [Homo sapiens]
          Length = 1062

 Score = 78.6 bits (192), Expect = 8e-14
 Identities = 88/425 (20%), Positives = 189/425 (44%), Gaps = 67/425 (15%)

Query: 1974 ESWSRIIDS--KFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMM----AD 2027
            +SW  +ID   K  ++Q      +QE ++EL+ TE  ++R L+++  ++   ++    + 
Sbjct: 374  DSWRELIDGHEKLTRRQ----CHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQESG 429

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVN-QFS 2086
            LL E +  E+LF  + E+  +H + +  ++      +++K+ +   + + GD L   +  
Sbjct: 430  LLCEVE-AERLFSNIPEIAQLHRRLWASVMA----PVLEKARRTRALLQPGDFLKGFKMF 484

Query: 2087 GENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLV 2146
            G     L K Y ++C +    + Y + L   +  F+A++         +RL + + +   
Sbjct: 485  GS----LFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540

Query: 2147 TQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYT 2206
             QR+TKYP+L + +L+ T++   ++  +A  +  V+  I  V++ +   +++ RL  + +
Sbjct: 541  HQRLTKYPLLLKSVLRKTEEPRAKEAVVAM-IGSVERFIHHVNACMRQRQERQRLAAVVS 599

Query: 2207 KTDSKSIMRMKSGQM------FAKEDL----------KRKKLVRDGSVFLKNAAGRLKEV 2250
            + D+  ++   S ++      F   DL          + ++L+ +GS+ +K       +V
Sbjct: 600  RIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDV 659

Query: 2251 QAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHE--EKGLFLISMGMTDP 2308
               L TD+L+  +   +        +++ VI    L+ + V  E  + G FL+       
Sbjct: 660  YCFLFTDLLLVTKAVKKA-------ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFH 712

Query: 2309 EMVEVH---ASSKEERNSWIQII------------------QDTINTLNRDEDEGIPSEN 2347
              V  +   AS +     W+  I                  Q  + +L  +EDE    E 
Sbjct: 713  SAVGAYTFQASGQALCRGWVDTIYNAQNQLQQLRAQEPPGSQQPLQSLEEEEDEQEEEEE 772

Query: 2348 EEEKK 2352
            EEE++
Sbjct: 773  EEEEE 777


>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 [Homo
            sapiens]
          Length = 596

 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)

Query: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027
            +K+  +  WS ++D    +      ++RQE IYE+ + E   +  LK+    Y   M+  
Sbjct: 148  AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 207

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087
             +  ++ +  +F  LD  I +H     RI E  K         +  +++IG +LV+    
Sbjct: 208  SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 259

Query: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147
             NA      Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 260  LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 312

Query: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 2207
             R+ KYP+L + IL+ T     + + L  ++ +++ V+  ++ K    E +  ++++   
Sbjct: 313  SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 372

Query: 2208 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 2265
             + +   R+++           K L+  G   L++ +G   ++   L  DILV  +   +
Sbjct: 373  DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 418

Query: 2266 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 2310
            ++++ +    Q    I +++L++ ++               ++ EK   +  +   DP  
Sbjct: 419  NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 475

Query: 2311 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 2363
             + H   A+    +  W   I+  I    +  +  E +G+P E  EE +     AR+L  
Sbjct: 476  AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 534

Query: 2364 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 2418
            Q        +  +E  E  +R      MAE S  L      TH  +   R   ++AL GG
Sbjct: 535  QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 589


>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [Homo
            sapiens]
          Length = 542

 Score = 77.8 bits (190), Expect = 1e-13
 Identities = 100/480 (20%), Positives = 201/480 (41%), Gaps = 67/480 (13%)

Query: 1968 SKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMAD 2027
            +K+  +  WS ++D    +      ++RQE IYE+ + E   +  LK+    Y   M+  
Sbjct: 94   AKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKL 153

Query: 2028 LLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSG 2087
             +  ++ +  +F  LD  I +H     RI E  K         +  +++IG +LV+    
Sbjct: 154  SIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATK--------PDGTVEQIGHILVSWLPR 205

Query: 2088 ENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVT 2147
             NA      Y  +C  +  +     D   +D R Q F+++ + S   R+L +   + +  
Sbjct: 206  LNA------YRGYC-SNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPR 258

Query: 2148 QRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTK 2207
             R+ KYP+L + IL+ T     + + L  ++ +++ V+  ++ K    E +  ++++   
Sbjct: 259  SRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYL 318

Query: 2208 TDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQ--EK 2265
             + +   R+++           K L+  G   L++ +G   ++   L  DILV  +   +
Sbjct: 319  DEKQRDPRIEAS----------KVLLCHGE--LRSKSGH--KLYIFLFQDILVLTRPVTR 364

Query: 2266 DQKYIFASLDQKSTVISLKKLIVREV---------------AHEEKGLFLISMGMTDPEM 2310
            ++++ +    Q    I +++L++ ++               ++ EK   +  +   DP  
Sbjct: 365  NERHSYQVYRQP---IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSP 421

Query: 2311 VEVH---ASSKEERNSWIQIIQDTI----NTLNRDEDEGIPSENEEEKKMLDTRARELKE 2363
             + H   A+    +  W   I+  I    +  +  E +G+P E  EE +     AR+L  
Sbjct: 422  AQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLP-ELHEECEGNHPSARKLTA 480

Query: 2364 QLHQKDQKILLLLEEKEMIFR-----DMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGG 2418
            Q        +  +E  E  +R      MAE S  L      TH  +   R   ++AL GG
Sbjct: 481  QRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSL-----KTHQTQPGIRRARDKALSGG 535


>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 76.6 bits (187), Expect = 3e-13
 Identities = 99/460 (21%), Positives = 198/460 (43%), Gaps = 57/460 (12%)

Query: 1896 QQSVSLSKSVSIQNI-----TGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEG 1950
            +++ +LS   SIQ       T + N E         S +TDS +     N S  S    G
Sbjct: 105  EKAATLSSDTSIQASEPLLDTHIVNGERDETATAPASPTTDSCDG----NASDSSYRTPG 160

Query: 1951 VGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQ----QKKDVVKRQEVIYELMQTE 2006
            +G  +   +     E E+K  E E+    ++ + L Q    ++ +  K  ++  EL+ TE
Sbjct: 161  IGPVLPLEER--GAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTE 218

Query: 2007 FHHVRTLKIMSGVYSQGMMADL---LFEQQMVEKLFPCLDELISIHSQFFQRILERKKES 2063
              +V  L ++  V+   ++ +     F  +MV K+F  +  + + HS+F    LE++ + 
Sbjct: 219  RAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQE 278

Query: 2064 LVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQA 2123
                        RIGD+L      +      K YG++    + ++   K++  +  +F++
Sbjct: 279  WETTP-------RIGDIL------QKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKS 325

Query: 2124 FVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKD 2183
             V++     +   L +   +L   QRI +Y +L +  L+    + ++  D  +SL ++  
Sbjct: 326  VVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIIST 385

Query: 2184 VIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNA 2243
                 +S +   E   +L EIY     +  +   S +           L+++G + LK A
Sbjct: 386  AASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNE-----------LIKEGQI-LKLA 433

Query: 2244 AGRL--KEVQAVLLTDILVFLQEKDQKYIFASLDQKSTV---ISLKKLIVREVAHEE-KG 2297
            A     +E    L  ++L++   K     F+ +  K TV   + +  + + E  +EE   
Sbjct: 434  ARNTSAQERYLFLFNNMLLYCVPK-----FSLVGSKFTVRTRVGIDGMKIVETQNEEYPH 488

Query: 2298 LFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNR 2337
             F +S        +E+ ASS +++  WI+ +Q+TI+  ++
Sbjct: 489  TFQVS---GKERTLELQASSAQDKEEWIKALQETIDAFHQ 525


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 75.9 bits (185), Expect = 5e-13
 Identities = 78/347 (22%), Positives = 145/347 (41%), Gaps = 27/347 (7%)

Query: 1994 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 2053
            KRQ  I+EL+ TE ++V  L++++ ++ + +M   L  ++ V  +F    ELI  + +  
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296

Query: 2054 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 2113
            + +  RKK      S +   +K IGD+L  Q          + Y +FC +        + 
Sbjct: 1297 KALRVRKK-----MSGEKMPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQQ 1345

Query: 2114 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 2173
               +   F+ FVK+       + + +   IL   QR+T+YP++ + IL+ T +N  +   
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405

Query: 2174 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 2233
            L  +L   +++   V+  V   E   RL  I      + +             L  +K +
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNS-VTNCLGPRKFL 1464

Query: 2234 RDGSVFLKNAAGRLKEVQAVLLTDILVFLQ------EKDQKYIF---ASLDQK--STVIS 2282
              G ++    A   KE+   L  D L+  Q            +F   ++L  K   T I 
Sbjct: 1465 HSGKLY---KAKSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIF 1521

Query: 2283 LKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQ 2329
            L +++V+          +  +   D  +  + A S  ER +W+Q I+
Sbjct: 1522 LNEVLVKLPTDPSGDEPIFHISHID-RVYTLRAESINERTAWVQKIK 1567



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 43/147 (29%), Positives = 87/147 (59%), Gaps = 12/147 (8%)

Query: 2540 LQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKR 2599
            L ++  +ED++  L ++       +     E+     LEK+RQ L   Q+++ + L +  
Sbjct: 329  LPEEPVLEDEQQQLEKKLPVTFEDKKRENFERGNLE-LEKRRQALLEQQRKEQERLAQLE 387

Query: 2600 RREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQK 2659
            R E+E + RER+ +ER+  L + E+++++ Q++LE++REE ++K      ++ER  AA++
Sbjct: 388  RAEQERKERERQEQERKRQL-ELEKQLEK-QRELERQREEERRK------EIERREAAKR 439

Query: 2660 QLEREQE---QLRREAERLSQRQTERD 2683
            +LER+++   +  R  E L+QR  E++
Sbjct: 440  ELERQRQLEWERNRRQELLNQRNKEQE 466



 Score = 53.9 bits (128), Expect = 2e-06
 Identities = 52/178 (29%), Positives = 87/178 (48%), Gaps = 23/178 (12%)

Query: 2530 ELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQK 2589
            EL    Q ++ QQ    E ++L   ERA      R     EQE++R LE ++Q    L+K
Sbjct: 364  ELEKRRQALLEQQRK--EQERLAQLERAEQERKERERQ--EQERKRQLELEKQ----LEK 415

Query: 2590 QQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDL----EKEREE---LQQ 2642
            Q+   LE +R  ER  E   RE  +RE    ++ E  +  +Q+L     KE+E+   L+ 
Sbjct: 416  QRE--LERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKA 473

Query: 2643 KKGTYQYDLERLRAAQKQLEREQEQLR------REAERLSQRQTERDLCQVSHPHTKL 2694
            KK T +++LE L   + QLE + + +R      R+    + +  E  + +++H   +L
Sbjct: 474  KKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQL 531



 Score = 48.5 bits (114), Expect = 9e-05
 Identities = 46/237 (19%), Positives = 109/237 (45%), Gaps = 18/237 (7%)

Query: 2491 QDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQK 2550
            Q++  T     L+     +L   L+ + + + + +     L   L+ V  QQ+S   D  
Sbjct: 508  QEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQV--QQNSLHRDSL 565

Query: 2551 LVLSERALTRSLSRP---SSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRR--REREW 2605
            + L      + L+R      L E EK+   + Q  D+ N Q ++ + +  K++  +++  
Sbjct: 566  VTLKRALEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSM 625

Query: 2606 EARERELREREALLAQREEEVQQGQQDL-EKEREELQQKKGTYQYDLERLRAAQKQLERE 2664
            EA   + +E+E  + + E++ ++ Q+   E++++ L+  +   ++   R    +++L+RE
Sbjct: 626  EAERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKRE 685

Query: 2665 QEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSL 2721
            +   +++ E   +++ +  L ++ H H +          P +P   +  S A+ G L
Sbjct: 686  ESVKKKDGEEKGKQEAQDKLGRLFHQHQE----------PAKPAVQAPWSTAEKGPL 732



 Score = 35.8 bits (81), Expect = 0.61
 Identities = 30/137 (21%), Positives = 67/137 (48%), Gaps = 9/137 (6%)

Query: 2540 LQQDSYIEDQKLVLSERALTRSLS---RPSSLIEQEKQRSLE---KQRQDLANLQKQQAQ 2593
            L+ +  +E Q+ +  +R   R      R ++  E E+QR LE    +RQ+L N + ++ +
Sbjct: 407  LELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQE 466

Query: 2594 YLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLER 2653
             +   + +++  E     L +++    Q E ++Q  +  L  +R+E++    + +  +  
Sbjct: 467  DIVVLKAKKKTLEFELEALNDKK---HQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAE 523

Query: 2654 LRAAQKQLEREQEQLRR 2670
            +   Q+QL+  Q+ L R
Sbjct: 524  ITHLQQQLQESQQMLGR 540


>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
          Length = 1670

 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 79/379 (20%), Positives = 155/379 (40%), Gaps = 35/379 (9%)

Query: 1994 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 2053
            KRQ  I+EL+QTE  ++  L+++  V+ + M       +  +  +F    ELI  +++  
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1241

Query: 2054 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 2113
            + +  RKK        +   ++ IGD+L  + S   A      Y +FC          + 
Sbjct: 1242 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1290

Query: 2114 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 2173
               +D  F+ F+KK  S    + + +   +L   QRIT+YP+L + IL+ T ++  +   
Sbjct: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350

Query: 2174 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 2233
            L  +L   +++   V+  V   E   RL  I      + +             L  +KL+
Sbjct: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT-NCLGPRKLL 1409

Query: 2234 RDGSVFLKNAAGRLKEVQAVLLTDILV-------FLQEKDQKYIFAS-----LDQKSTVI 2281
              G ++   +    KE+   L  D L+       F      + +F+S          T I
Sbjct: 1410 HSGKLYKTKSN---KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPI 1466

Query: 2282 SLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDE 2341
             L +++V+          +  +   D  +  +   +  ER +W+Q I+          ++
Sbjct: 1467 FLNEVLVKLPTDPSSDEPVFHISHID-RVYTLRTDNINERTAWVQKIKAA-------SEQ 1518

Query: 2342 GIPSENEEEKKMLDTRARE 2360
             I +E ++ +K    R+++
Sbjct: 1519 YIDTEKKKREKAYQARSQK 1537



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 40/111 (36%), Positives = 72/111 (64%), Gaps = 13/111 (11%)

Query: 2577 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2636
            LEK+RQ L   Q+++A+   + ++ + EWE ++REL+E+E       E+  + Q++LE++
Sbjct: 378  LEKRRQALMEQQQREAE--RKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQ 435

Query: 2637 REELQQKKGTYQYDLERLRAAQKQLER----EQEQLRREAERLSQRQTERD 2683
            REE ++K      D+ER  AA+++LER    E E++RR+ E L+Q+  E++
Sbjct: 436  REEERRK------DIERREAAKQELERQRRLEWERIRRQ-ELLNQKNREQE 479



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 39/148 (26%), Positives = 76/148 (51%), Gaps = 19/148 (12%)

Query: 2547 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 2606
            ED++    ER       R  +L+EQ+++ +  K +++    +++Q +  E++ +++ E E
Sbjct: 364  EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELE 423

Query: 2607 ARERELREREALLAQREEEVQQ-------GQQDLEKER---------EELQQKKGTYQYD 2650
             R  + RE E    QREEE ++        +Q+LE++R         +EL  +K   Q +
Sbjct: 424  KRLEKQRELER---QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480

Query: 2651 LERLRAAQKQLEREQEQLRREAERLSQR 2678
            + RL + +K L  E E L  + +++S R
Sbjct: 481  IVRLNSKKKNLHLELEALNGKHQQISGR 508



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 32/102 (31%), Positives = 60/102 (58%), Gaps = 8/102 (7%)

Query: 2588 QKQQAQYLEEKRRREREWEARERELREREALLAQREEEV----QQGQQDLEKEREELQQK 2643
            QK+     E+KR+   E    E E R R+AL+ Q++ E     Q+ +++ E+++ ELQ++
Sbjct: 356  QKKLPVTFEDKRKANYERGNMELEKR-RQALMEQQQREAERKAQKEKEEWERKQRELQEQ 414

Query: 2644 KGTYQYDLERLRAAQKQLEREQEQLRR---EAERLSQRQTER 2682
            +   Q +LE+    Q++LER++E+ RR   E    ++++ ER
Sbjct: 415  EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456



 Score = 44.7 bits (104), Expect = 0.001
 Identities = 48/226 (21%), Positives = 100/226 (44%), Gaps = 42/226 (18%)

Query: 2499 DSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERAL 2558
            D  LKK      + +L +  +  +  +  L + L   Q  ++    Y+  +K +L+ER  
Sbjct: 511  DVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLI----YLVPEKQLLNERIK 566

Query: 2559 TRSLSR-PSSLIEQEKQRSLEKQ------RQDLANLQKQQAQYLEE-------------- 2597
                S  P S +    ++SLEK+      ++ L  L+K+ A  L E              
Sbjct: 567  NMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKELRET 626

Query: 2598 --------------KRRREREWEARERELREREALLAQREEEVQQGQQDLEKE--REELQ 2641
                          KR + +E E +  EL +++ L  +   + +QG+++L KE  R+E +
Sbjct: 627  YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEE 686

Query: 2642 QKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQV 2687
            +K+   Q +  + +  +++ + E++Q R++ + L   + +R+   V
Sbjct: 687  EKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRETASV 731



 Score = 42.4 bits (98), Expect = 0.007
 Identities = 54/254 (21%), Positives = 116/254 (45%), Gaps = 21/254 (8%)

Query: 2572 EKQRSLEKQRQD--LANLQKQQAQYLEEKRRREREWE-ARERELREREALLAQREEEVQQ 2628
            EKQR LE+QR++    ++++++A   E +R+R  EWE  R +EL  ++    +    +  
Sbjct: 427  EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNS 486

Query: 2629 GQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREA--ERLSQRQTERDLCQ 2686
             +++L  E E L  K       L+ +R  ++  + E E L ++   E +  +Q +++L +
Sbjct: 487  KKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQE 546

Query: 2687 VSH------PHTKLM--RIPS--FFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISR 2736
              +      P  +L+  RI +  F  +P+     S  S+    SL+ E      +  +  
Sbjct: 547  YQNKLIYLVPEKQLLNERIKNMQFSNTPD-----SGVSLLHKKSLEKEELCQRLKEQLDA 601

Query: 2737 THKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQP 2796
              K+     +    S  N+  E +        A  +L+ + + K K+ ++K+ +  + + 
Sbjct: 602  LEKETAS-KLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK 660

Query: 2797 GDGPASEVSAEGEE 2810
             +  A+  + +G+E
Sbjct: 661  LEDEAARKAKQGKE 674


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 74.7 bits (182), Expect = 1e-12
 Identities = 79/379 (20%), Positives = 155/379 (40%), Gaps = 35/379 (9%)

Query: 1994 KRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFF 2053
            KRQ  I+EL+QTE  ++  L+++  V+ + M       +  +  +F    ELI  +++  
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1268

Query: 2054 QRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKD 2113
            + +  RKK        +   ++ IGD+L  + S   A      Y +FC          + 
Sbjct: 1269 KALRVRKKTG-----GEKMPVQMIGDILAAELSHMQA------YIRFCSCQLNGAALLQQ 1317

Query: 2114 LYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQED 2173
               +D  F+ F+KK  S    + + +   +L   QRIT+YP+L + IL+ T ++  +   
Sbjct: 1318 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1377

Query: 2174 LAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLV 2233
            L  +L   +++   V+  V   E   RL  I      + +             L  +KL+
Sbjct: 1378 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT-NCLGPRKLL 1436

Query: 2234 RDGSVFLKNAAGRLKEVQAVLLTDILV-------FLQEKDQKYIFAS-----LDQKSTVI 2281
              G ++   +    KE+   L  D L+       F      + +F+S          T I
Sbjct: 1437 HSGKLYKTKSN---KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPI 1493

Query: 2282 SLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDE 2341
             L +++V+          +  +   D  +  +   +  ER +W+Q I+          ++
Sbjct: 1494 FLNEVLVKLPTDPSSDEPVFHISHID-RVYTLRTDNINERTAWVQKIKAA-------SEQ 1545

Query: 2342 GIPSENEEEKKMLDTRARE 2360
             I +E ++ +K    R+++
Sbjct: 1546 YIDTEKKKREKAYQARSQK 1564



 Score = 62.8 bits (151), Expect = 5e-09
 Identities = 41/111 (36%), Positives = 71/111 (63%), Gaps = 13/111 (11%)

Query: 2577 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2636
            LEK+RQ L   Q+++A+   +K + E  WE ++REL+E+E       E+  + Q++LE++
Sbjct: 378  LEKRRQALMEQQQREAERKAQKEKEE--WERKQRELQEQEWKKQLELEKRLEKQRELERQ 435

Query: 2637 REELQQKKGTYQYDLERLRAAQKQLER----EQEQLRREAERLSQRQTERD 2683
            REE ++K      D+ER  AA+++LER    E E++RR+ E L+Q+  E++
Sbjct: 436  REEERRK------DIERREAAKQELERQRRLEWERIRRQ-ELLNQKNREQE 479



 Score = 51.2 bits (121), Expect = 1e-05
 Identities = 39/148 (26%), Positives = 76/148 (51%), Gaps = 19/148 (12%)

Query: 2547 EDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWE 2606
            ED++    ER       R  +L+EQ+++ +  K +++    +++Q +  E++ +++ E E
Sbjct: 364  EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELE 423

Query: 2607 ARERELREREALLAQREEEVQQ-------GQQDLEKER---------EELQQKKGTYQYD 2650
             R  + RE E    QREEE ++        +Q+LE++R         +EL  +K   Q +
Sbjct: 424  KRLEKQRELER---QREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480

Query: 2651 LERLRAAQKQLEREQEQLRREAERLSQR 2678
            + RL + +K L  E E L  + +++S R
Sbjct: 481  IVRLNSKKKNLHLELEALNGKHQQISGR 508



 Score = 48.1 bits (113), Expect = 1e-04
 Identities = 32/102 (31%), Positives = 60/102 (58%), Gaps = 8/102 (7%)

Query: 2588 QKQQAQYLEEKRRREREWEARERELREREALLAQREEEV----QQGQQDLEKEREELQQK 2643
            QK+     E+KR+   E    E E R R+AL+ Q++ E     Q+ +++ E+++ ELQ++
Sbjct: 356  QKKLPVTFEDKRKANYERGNMELEKR-RQALMEQQQREAERKAQKEKEEWERKQRELQEQ 414

Query: 2644 KGTYQYDLERLRAAQKQLEREQEQLRR---EAERLSQRQTER 2682
            +   Q +LE+    Q++LER++E+ RR   E    ++++ ER
Sbjct: 415  EWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456



 Score = 40.8 bits (94), Expect = 0.019
 Identities = 29/100 (29%), Positives = 49/100 (49%), Gaps = 15/100 (15%)

Query: 2572 EKQRSLEKQRQD--LANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQG 2629
            EKQR LE+QR++    ++++++A   E +R+R  EWE        R+ LL Q+  E    
Sbjct: 427  EKQRELERQREEERRKDIERREAAKQELERQRRLEWER-----IRRQELLNQKNRE---- 477

Query: 2630 QQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLR 2669
                ++E   L  KK     +LE L    +Q+    + +R
Sbjct: 478  ----QEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVR 513



 Score = 38.5 bits (88), Expect = 0.095
 Identities = 26/113 (23%), Positives = 61/113 (53%), Gaps = 3/113 (2%)

Query: 2577 LEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKE 2636
            L++ R+     Q    Q  + KR + +E E +  EL +++ L  +   + +QG+++L KE
Sbjct: 647  LKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKE 706

Query: 2637 --REELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQV 2687
              R+E ++K+   Q +  + +  +++ + E++Q R++ + L   + +R+   V
Sbjct: 707  NLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-RKDKDTLKAEEKKRETASV 758



 Score = 37.4 bits (85), Expect = 0.21
 Identities = 26/95 (27%), Positives = 53/95 (55%), Gaps = 8/95 (8%)

Query: 2569 IEQEKQRSLEKQRQDLANLQKQQAQYLEE-KRRREREWEARERELREREALLAQREEEVQ 2627
            I+++K + +E++R +L   +K + +   + K+ +E  W+   R+  E E     +EE+ Q
Sbjct: 667  IKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRK-EEEEKQKRLQEEKTQ 725

Query: 2628 QGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLE 2662
            +  Q+ E++ EE Q+K      D + L+A +K+ E
Sbjct: 726  EKIQEEERKAEEKQRK------DKDTLKAEEKKRE 754


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 71.6 bits (174), Expect = 1e-11
 Identities = 127/714 (17%), Positives = 264/714 (36%), Gaps = 68/714 (9%)

Query: 376  VERKGEEVEPAPIVD-SGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPT 434
            +E  G++ EP   V  S T SD +S      D   K  +G     + +E  G   +   +
Sbjct: 423  IEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQG-DDPNSSDESNGNDDANSES 481

Query: 435  DQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGI-STTNVSTPDTAGEMEHGLMNPDATV 493
            D  S S GDA    D   + G    S G E     ST++ +  D+ G   +G  + D + 
Sbjct: 482  DNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKS- 540

Query: 494  WKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAASSLDGNKPAESSL 553
                   G+   +  ++ +  ++ +SD   +S      S  +    +S  D +  ++S  
Sbjct: 541  -----DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDS 595

Query: 554  AFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGE 613
            + S+  + +  ++++  S    +S+D+  D +     ++  D  SD  +      +   +
Sbjct: 596  SDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSD------SNSSD 649

Query: 614  AMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVT 673
            +   SD              +S++++S   S    SS            +DS+   ++  
Sbjct: 650  SSDNSD--------------SSDSSNSSNSSDSSDSSD----------SSDSSSSSDSSN 685

Query: 674  SSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQERADFCP 733
            SS    +    N    S+S+ +    S D  D+S+     + +  S    D+   +D   
Sbjct: 686  SSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSD 745

Query: 734  FKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGS 793
                 N     D              S+        +     D +  SDS  S  +S  S
Sbjct: 746  SSDSSNSSDSSDSSDS----------SNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795

Query: 794  ESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDG--NSNEPDTRPLEDRAVGL-STS 850
            +S    D+ +   S     ++  +   ++D  +  D   +SN  D+    D + G  S S
Sbjct: 796  DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855

Query: 851  STAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKATLALDSVLTE 910
            S  ++  +   ++  +      +        E+ N   ++DSS  S   ++ + +S  + 
Sbjct: 856  SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915

Query: 911  EGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISA 970
            +      S SS + E       + SS   N+  S    +   +     D+    + S S+
Sbjct: 916  DS-----SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS----SDSSNSSDSSNSS 966

Query: 971  DCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQ 1030
            D +   +   S+S  +S +   +++  + + +   +      ++ S     +S ++ S  
Sbjct: 967  DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSD 1026

Query: 1031 EALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSACEVS 1084
             +  ++ + S+       D SD SD+ + S  S       ++ S   + + + S
Sbjct: 1027 SSNSSDSSDSS-------DSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 1073



 Score = 60.8 bits (146), Expect = 2e-08
 Identities = 122/747 (16%), Positives = 276/747 (36%), Gaps = 49/747 (6%)

Query: 304  AQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIVEEE 363
            + D  S+  ++      + + +D    S S +++S      S  + ++S  D S     +
Sbjct: 590  SSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSD 649

Query: 364  NTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQ----DSCLQSLPDCGVKGTEGLSSCG 419
            ++D S    +       +  + +   DS + SD     DS   S      + ++   S  
Sbjct: 650  SSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709

Query: 420  NRNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDT- 478
            + + ++   S+   +D +S +S D+    +      ++  S+  +    S ++ S+  + 
Sbjct: 710  SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769

Query: 479  ---AGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPN 535
               + +      + D+    N     +S+     +++  ++ +SD    S   D  +  +
Sbjct: 770  SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSD----SSDSDSSNSSD 825

Query: 536  CAPAASSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKD 595
             + ++ S D +  ++SS +  + + S   ++    S +  +S+D+    NS     +   
Sbjct: 826  SSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS-----SDSS 880

Query: 596  KISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICST 655
              SD  E      +      S SD +      D     NS  +S  + S    +S   S 
Sbjct: 881  DSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSN 940

Query: 656  TGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAH 715
            + D    +DS+   ++  SS    +    +  S   S ++    S D  D+S   D    
Sbjct: 941  SSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDS 1000

Query: 716  TVTSDPVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVP 775
            + +SD   D+ + +D              D       +N  +            +     
Sbjct: 1001 SNSSDS-SDSSDSSD---------SSNSSDSSNSSDSSNSSD----------SSDSSDSS 1040

Query: 776  DQAVISDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEP 835
            D +  SDS+ S  +S  S+S    D+     S     + + +   +++  D  D +SN  
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDS-----SDSSDSSDSSDSSDSSESSDSSD-SSNSS 1094

Query: 836  DTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQ 895
            D+    D     S SS +++      ++  +      +        ++ N   ++DSS  
Sbjct: 1095 DSSDSSDS----SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES 1150

Query: 896  S-VGKATLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTP 954
            S    ++ + DS  + +      S  S+      D + +  S   +  S  +   +    
Sbjct: 1151 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1210

Query: 955  PPGQDTQQFHEKSISADCA-KDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGA 1013
                D+    + S S+D +  +++   S+S  +S +   +++  + + +   S       
Sbjct: 1211 SDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESD 1270

Query: 1014 AQSLVPPGASLATESRQEALGAEHNSS 1040
            +QS    G +  ++S  ++ G++ N S
Sbjct: 1271 SQSKSGNGNNNGSDSDSDSEGSDSNHS 1297



 Score = 43.9 bits (102), Expect = 0.002
 Identities = 73/383 (19%), Positives = 127/383 (33%), Gaps = 13/383 (3%)

Query: 1401 DAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFHSPSDDMDSIIFPKPE 1460
            D+++   S  S +  N  D     + ++          SDS    + SD  DS       
Sbjct: 736  DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795

Query: 1461 EEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQIL--KPNRSRDRQSLDGFYSHGMGA 1518
            +   + D + SS S+D + S D  SS+ SD S S       N S    S D        +
Sbjct: 796  DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855

Query: 1519 EGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEM 1578
              R   S  +D  D  +    S +   ++ +   +S  S             + +SD++ 
Sbjct: 856  SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDS----------SDSSNSSDSDS 905

Query: 1579 NHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKPSSSLEVSSANAEELRHPFSGEE 1638
            +  S+     D          S S +  +  +   N   SS    S+N+ +  +      
Sbjct: 906  SDSSNSSDSSDSSNSSDSSESSNSSDN-SNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSN 964

Query: 1639 RVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLMTISHPG 1698
              DS  S S +  +S               S     +  + +  S  +   S  + S   
Sbjct: 965  SSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024

Query: 1699 LDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSS 1758
             D+S    S+  + S++ ++S    + +   +S    DS   S +  S   S   +   S
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084

Query: 1759 SKKSKEKEKEKDKIKEKEKDSKD 1781
            S  S               DS D
Sbjct: 1085 SDSSDSSNSSDSSDSSDSSDSSD 1107



 Score = 40.0 bits (92), Expect = 0.032
 Identities = 112/572 (19%), Positives = 188/572 (32%), Gaps = 32/572 (5%)

Query: 1427 TSKQGVLKRESGSDSDLFHSPS--------DDMDSIIFPKPEEEHLACDITGSSSSTDDT 1478
            +  +G    +S S SD  +S S        DD D     K + +    D + SS+S+D +
Sbjct: 505  SDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSS 564

Query: 1479 ASLDRHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEM 1538
             S D  SS  +  S S     + S    S     S+   +      S+ +D  D  + + 
Sbjct: 565  DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624

Query: 1539 DSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHR 1598
            DS      +     S  +S S     S     + +SD+  +  SS               
Sbjct: 625  DSSKSESDSSD---SDSKSDSSDSNSSDSSDNSDSSDSSNSSNSS------------DSS 669

Query: 1599 RSFSLEGLTGGAGVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREH 1658
             S      +  +   N   SS    S+N+ E        +   S  S S     SD    
Sbjct: 670  DSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSS 729

Query: 1659 RMFDQQICHRS-----KQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTS 1713
               D      S          N   S+ SS  + S S  + S    D+S   +S+  N S
Sbjct: 730  NSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNS-SDSSDSSDSSDSSDSSNSSDSNDS 788

Query: 1714 ANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTF-SYIKNKMSSSKKSKEKEKEKDKI 1772
            +N ++S    N +   +S    DS   S +  S +  S   +  S S  S +     D  
Sbjct: 789  SNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS 848

Query: 1773 KEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTN-KDAYTCANCSAFVHKGC 1831
               + DS ++     + +    S        S S      +N  D+   +N S       
Sbjct: 849  DGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDS 908

Query: 1832 RESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFA 1891
              S  S           S  + D S+       +  S   +   S+       ++    +
Sbjct: 909  SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDS 968

Query: 1892 NRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTES-LTDEG 1950
            +  +    S S + S  + +   +D + S+     S S+DS +     N S  S  +D  
Sbjct: 969  SDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028

Query: 1951 VGTDMNEGQLLGDFEIESKQLEAESWSRIIDS 1982
              +D ++     D    S   ++   S   DS
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1060



 Score = 37.7 bits (86), Expect = 0.16
 Identities = 64/345 (18%), Positives = 112/345 (32%)

Query: 1437 SGSDSDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQI 1496
            S SDS    + SD  DS       E   + D + SS S++ + S D   S  S  S +  
Sbjct: 901  SDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSS 960

Query: 1497 LKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMR 1556
               N S    S     S    +      S+ +D  D  +    S +   ++ S   +S  
Sbjct: 961  DSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSD 1020

Query: 1557 SLSPFRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKP 1616
            S +     +     +++  ++ +  S      D          S S +         +  
Sbjct: 1021 SSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1080

Query: 1617 SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY 1676
            SS    SS ++       S +    S  S S +  +S    +          S     + 
Sbjct: 1081 SSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN 1140

Query: 1677 CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD 1736
             + +  S  +   S  + S    D+S    S+  + S+N ++S    + +    S    D
Sbjct: 1141 SSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSD 1200

Query: 1737 SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKD 1781
            S   S +  S   S   +   SS  S   +  +        DS D
Sbjct: 1201 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSD 1245



 Score = 34.3 bits (77), Expect = 1.8
 Identities = 64/345 (18%), Positives = 108/345 (31%), Gaps = 1/345 (0%)

Query: 1437 SGSDSDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQI 1496
            + SDS      S+  DS       E   + D + SS+S+D  +S   +SS  SD S S  
Sbjct: 863  NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSD 922

Query: 1497 LKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMR 1556
               + +    S     S+   +      S  +D  +   +  +S     +N S    S  
Sbjct: 923  SSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSN-SSDSSNSSDSSDSNSSDSSDSSN 981

Query: 1557 SLSPFRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKP 1616
            S             +++  +  +  S      D          S S           +  
Sbjct: 982  SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSD 1041

Query: 1617 SSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNY 1676
            SS    SS +++      S +    S  S S +  +S             + S     + 
Sbjct: 1042 SSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSD 1101

Query: 1677 CTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKD 1736
             + +  S  +   S  + S    D+S    S+  + S+N ++S      +    S    D
Sbjct: 1102 SSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSD 1161

Query: 1737 SEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKD 1781
            S   S +  S   S   N   SS  S   +           DS D
Sbjct: 1162 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1206



 Score = 33.5 bits (75), Expect = 3.0
 Identities = 69/390 (17%), Positives = 119/390 (30%), Gaps = 5/390 (1%)

Query: 1408 SKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEEEHLACD 1467
            SK      N  D     + +           SDS      S   DS       +   + +
Sbjct: 638  SKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697

Query: 1468 ITGSSSSTDDTASLDRHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGMGAEGRESESEP 1527
             + SS S+D + S    SS  S+ + S     N S    S +   S         S+S  
Sbjct: 698  SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD 757

Query: 1528 ADPGDVEEEEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEMNHRSSMRVL 1587
            +       +  DS     ++ S   S     S     S     + +S++  +  SS    
Sbjct: 758  SSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSD 817

Query: 1588 GDVVRRPPIHRRSFSLEGLTGGAGVGNKPSS-SLEVSSANAEELRHPFSGEERVDSLVSL 1646
             D          S S +         +  SS   +  S+N  +  +     +  DS  S 
Sbjct: 818  SDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSS 877

Query: 1647 SEEDLESDQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFH 1706
               D           D      S     +  +++  S  + + S  + S    DNS    
Sbjct: 878  DSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSD 937

Query: 1707 STFHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKE 1766
            S+  + S++ ++S    + +    S +  DS   + +  S +     N   SS  S   +
Sbjct: 938  SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDS----SNSSDSSDSSDSSD 993

Query: 1767 KEKDKIKEKEKDSKDKEKDKKTVNGHTFSS 1796
                       DS D      + N    S+
Sbjct: 994  SSDSSDSSNSSDSSDSSDSSDSSNSSDSSN 1023



 Score = 32.7 bits (73), Expect = 5.2
 Identities = 41/187 (21%), Positives = 64/187 (34%), Gaps = 5/187 (2%)

Query: 1401 DAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFHSPSDDMDSIIFPKPE 1460
            D++    S  S +  N  D     + +           SDS      SD  DS       
Sbjct: 1107 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSS 1166

Query: 1461 EEHLACDITGSSSSTDDTASLD----RHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGM 1516
            +   + D + SS+S+D + S D      SS  SD S S     +      S     S   
Sbjct: 1167 DSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1226

Query: 1517 GAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDA 1576
             +      S+ +D  D  +    S +   ++ S   S     S  +  S G G N  SD+
Sbjct: 1227 DSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS-GNGNNNGSDS 1285

Query: 1577 EMNHRSS 1583
            + +   S
Sbjct: 1286 DSDSEGS 1292


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.127    0.355 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 113,381,572
Number of Sequences: 37866
Number of extensions: 5705585
Number of successful extensions: 53091
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 598
Number of HSP's successfully gapped in prelim test: 1164
Number of HSP's that attempted gapping in prelim test: 25335
Number of HSP's gapped (non-prelim): 16442
length of query: 2813
length of database: 18,247,518
effective HSP length: 120
effective length of query: 2693
effective length of database: 13,703,598
effective search space: 36903789414
effective search space used: 36903789414
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 71 (32.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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