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Search of human proteins with 21450842
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
(508 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 1034 0.0
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 983 0.0
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 946 0.0
gi|187475373 c-src tyrosine kinase [Homo sapiens] 483 e-136
gi|4758078 c-src tyrosine kinase [Homo sapiens] 483 e-136
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 282 6e-76
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 282 6e-76
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 273 4e-73
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 273 4e-73
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 271 8e-73
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 268 7e-72
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 264 2e-70
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens] 264 2e-70
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 263 2e-70
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 263 2e-70
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 261 1e-69
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 261 1e-69
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 261 1e-69
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 261 1e-69
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 261 1e-69
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens] 261 1e-69
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 259 4e-69
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 259 4e-69
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 259 5e-69
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 259 5e-69
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 259 5e-69
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 258 1e-68
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 255 6e-68
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 255 8e-68
gi|4503787 fyn-related kinase [Homo sapiens] 245 6e-65
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 1034 bits (2674), Expect = 0.0
Identities = 508/508 (100%), Positives = 508/508 (100%)
Query: 1 MQGHFPAERREGRPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEH 60
MQGHFPAERREGRPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEH
Sbjct: 1 MQGHFPAERREGRPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEH 60
Query: 61 TRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSL 120
TRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSL
Sbjct: 61 TRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSL 120
Query: 121 MPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLT 180
MPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLT
Sbjct: 121 MPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLT 180
Query: 181 IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGA 240
IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGA
Sbjct: 181 IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGA 240
Query: 241 QIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG 300
QIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG
Sbjct: 241 QIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG 300
Query: 301 LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL 360
LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL
Sbjct: 301 LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL 360
Query: 361 VSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS 420
VSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS
Sbjct: 361 VSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS 420
Query: 421 YGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLA 480
YGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLA
Sbjct: 421 YGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLA 480
Query: 481 RELRSAGAPASVSGQDADGSTSPRSQEP 508
RELRSAGAPASVSGQDADGSTSPRSQEP
Sbjct: 481 RELRSAGAPASVSGQDADGSTSPRSQEP 508
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 983 bits (2540), Expect = 0.0
Identities = 483/483 (100%), Positives = 483/483 (100%)
Query: 26 VSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENK 85
VSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENK
Sbjct: 25 VSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENK 84
Query: 86 SWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLF 145
SWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLF
Sbjct: 85 SWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLF 144
Query: 146 LVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAIC 205
LVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAIC
Sbjct: 145 LVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAIC 204
Query: 206 TKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI 265
TKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI
Sbjct: 205 TKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI 264
Query: 266 KCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALV 325
KCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALV
Sbjct: 265 KCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALV 324
Query: 326 NTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS 385
NTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS
Sbjct: 325 NTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS 384
Query: 386 RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRME 445
RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRME
Sbjct: 385 RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRME 444
Query: 446 PPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRS 505
PPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRS
Sbjct: 445 PPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRS 504
Query: 506 QEP 508
QEP
Sbjct: 505 QEP 507
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 946 bits (2444), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 43 MPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLA 102
MPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLA
Sbjct: 1 MPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLA 60
Query: 103 AGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVS 162
AGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVS
Sbjct: 61 AGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVS 120
Query: 163 FGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEE 222
FGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEE
Sbjct: 121 FGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEE 180
Query: 223 ELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMT 282
ELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMT
Sbjct: 181 ELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMT 240
Query: 283 KMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 342
KMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME
Sbjct: 241 KMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 300
Query: 343 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKF 402
YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKF
Sbjct: 301 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKF 360
Query: 403 TSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCW 462
TSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCW
Sbjct: 361 TSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCW 420
Query: 463 EAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP 508
EAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
Sbjct: 421 EAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP 466
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 483 bits (1242), Expect = e-136
Identities = 235/434 (54%), Positives = 316/434 (72%), Gaps = 3/434 (0%)
Query: 48 WAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR 107
W GT+CI K +L F KGDV+TI+ ++ +WY+ K+ G+EG++ A ++
Sbjct: 8 WPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQ 66
Query: 108 EREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDV 167
+RE + A KLSLMPWFHGKI+ ++A + L PPE GLFLVRES +PGDY LCVS V
Sbjct: 67 KREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKV 126
Query: 168 IHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA 227
HYR+++ L+IDE V+F NLM +VEHY+ D +CT+L++PK GT +A++E R+
Sbjct: 127 EHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186
Query: 228 GWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHE 287
GW LN++ L L IG+GEFG V+ G+Y G KVAVK IK D TAQAFL E +VMT+++H
Sbjct: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHS 246
Query: 288 NLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE 345
NLV+LLGVI+ + GLYIV E+++KG+LV++LR+RGR+++ LL+FSL V E MEYLE
Sbjct: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306
Query: 346 SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSK 405
VHRDLAARN+LVSED VAKVSDFGL K D+ +LPVKWTAPEAL+ KF++K
Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366
Query: 406 SDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAE 465
SDVWSFG+LLWE++S+GR PYP++ LK+V VEKGY+M+ P+GCP V+ +M +CW +
Sbjct: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 426
Query: 466 PARRPPFRKLAEKL 479
A RP F +L E+L
Sbjct: 427 AAMRPSFLQLREQL 440
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 483 bits (1242), Expect = e-136
Identities = 235/434 (54%), Positives = 316/434 (72%), Gaps = 3/434 (0%)
Query: 48 WAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR 107
W GT+CI K +L F KGDV+TI+ ++ +WY+ K+ G+EG++ A ++
Sbjct: 8 WPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQ 66
Query: 108 EREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDV 167
+RE + A KLSLMPWFHGKI+ ++A + L PPE GLFLVRES +PGDY LCVS V
Sbjct: 67 KREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKV 126
Query: 168 IHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA 227
HYR+++ L+IDE V+F NLM +VEHY+ D +CT+L++PK GT +A++E R+
Sbjct: 127 EHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186
Query: 228 GWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHE 287
GW LN++ L L IG+GEFG V+ G+Y G KVAVK IK D TAQAFL E +VMT+++H
Sbjct: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHS 246
Query: 288 NLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE 345
NLV+LLGVI+ + GLYIV E+++KG+LV++LR+RGR+++ LL+FSL V E MEYLE
Sbjct: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306
Query: 346 SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSK 405
VHRDLAARN+LVSED VAKVSDFGL K D+ +LPVKWTAPEAL+ KF++K
Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366
Query: 406 SDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAE 465
SDVWSFG+LLWE++S+GR PYP++ LK+V VEKGY+M+ P+GCP V+ +M +CW +
Sbjct: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 426
Query: 466 PARRPPFRKLAEKL 479
A RP F +L E+L
Sbjct: 427 AAMRPSFLQLREQL 440
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 282 bits (721), Expect = 6e-76
Identities = 161/428 (37%), Positives = 248/428 (57%), Gaps = 25/428 (5%)
Query: 66 GELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFH 125
G+L F KG+ + ILE ++ W++ + T+GQEG + + + +L +P WF
Sbjct: 78 GDLGFEKGEQLRILE--QSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP------WFF 129
Query: 126 GKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-G 177
+S ++A +QL P + G FL+RES G + L V + G V HY++ + D G
Sbjct: 130 KNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNG 189
Query: 178 HLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLT 237
I + F L ++V HY+ +CT+L RP + T+ ++ W + + L
Sbjct: 190 GFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ---TQKPQKPWWEDEWEVPRETLK 246
Query: 238 LGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKC-DVTAQAFLDETAVMTKMQHENLVRLLGV 295
L ++G G+FG V G Y G KVAVK++K ++ AFL E +M ++QH+ LVRL V
Sbjct: 247 LVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAV 306
Query: 296 ILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355
+ + +YI+ E++ G+LV+FL+T + +LL + +AEGM ++E + +HRDL
Sbjct: 307 VTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLR 366
Query: 356 ARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSF 411
A NILVS+ L K++DFGLA+ E + ++ P+KWTAPEA+ +G FT KSDVWSF
Sbjct: 367 AANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSF 426
Query: 412 GVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPP 471
G+LL E+ ++GR PYP M+ EV + +E+GYRM P+ CP ++ LM CW+ P RP
Sbjct: 427 GILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPT 486
Query: 472 FRKLAEKL 479
F L L
Sbjct: 487 FDYLRSVL 494
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 282 bits (721), Expect = 6e-76
Identities = 161/428 (37%), Positives = 248/428 (57%), Gaps = 25/428 (5%)
Query: 66 GELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFH 125
G+L F KG+ + ILE ++ W++ + T+GQEG + + + +L +P WF
Sbjct: 78 GDLGFEKGEQLRILE--QSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP------WFF 129
Query: 126 GKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-G 177
+S ++A +QL P + G FL+RES G + L V + G V HY++ + D G
Sbjct: 130 KNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNG 189
Query: 178 HLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLT 237
I + F L ++V HY+ +CT+L RP + T+ ++ W + + L
Sbjct: 190 GFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ---TQKPQKPWWEDEWEVPRETLK 246
Query: 238 LGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKC-DVTAQAFLDETAVMTKMQHENLVRLLGV 295
L ++G G+FG V G Y G KVAVK++K ++ AFL E +M ++QH+ LVRL V
Sbjct: 247 LVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAV 306
Query: 296 ILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355
+ + +YI+ E++ G+LV+FL+T + +LL + +AEGM ++E + +HRDL
Sbjct: 307 VTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLR 366
Query: 356 ARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSF 411
A NILVS+ L K++DFGLA+ E + ++ P+KWTAPEA+ +G FT KSDVWSF
Sbjct: 367 AANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSF 426
Query: 412 GVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPP 471
G+LL E+ ++GR PYP M+ EV + +E+GYRM P+ CP ++ LM CW+ P RP
Sbjct: 427 GILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPT 486
Query: 472 FRKLAEKL 479
F L L
Sbjct: 487 FDYLRSVL 494
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 273 bits (697), Expect = 4e-73
Identities = 166/425 (39%), Positives = 242/425 (56%), Gaps = 27/425 (6%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L+F+KG+ + I+ E W+ ++GQ G + + + +++ A+ W+ G
Sbjct: 102 DLSFKKGERLQIVNNTEG-DWWLAHSLSTGQTGYIPSNYVAPSDSIQAEE------WYFG 154
Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
KI+ +E+ + L E+ G FLVRES G Y L VS G +V HY++ D G
Sbjct: 155 KITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGG 214
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKL--VRPKRKHGTKSAEEELARAGWLLNLQHL 236
I F +L +V +YSK +C +L V P K T+ LA+ W + + L
Sbjct: 215 FYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG----LAKDAWEIPRESL 270
Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
L ++G+G FG V G + G +VA+K +K ++ +AFL E VM K++HE LV+L
Sbjct: 271 RLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330
Query: 295 VILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL 354
V+ + +YIV E++SKG+L++FL+ + QL+ + +A GM Y+E VHRDL
Sbjct: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390
Query: 355 AARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWS 410
A NILV E+LV KV+DFGLA+ E ++ P+KWTAPEA +G+FT KSDVWS
Sbjct: 391 RAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 450
Query: 411 FGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470
FG+LL E+ + GR PYP M +EV + VE+GYRM P CP +H LM CW EP RP
Sbjct: 451 FGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP 510
Query: 471 PFRKL 475
F L
Sbjct: 511 TFEYL 515
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 273 bits (697), Expect = 4e-73
Identities = 166/425 (39%), Positives = 242/425 (56%), Gaps = 27/425 (6%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L+F+KG+ + I+ E W+ ++GQ G + + + +++ A+ W+ G
Sbjct: 102 DLSFKKGERLQIVNNTEG-DWWLAHSLSTGQTGYIPSNYVAPSDSIQAEE------WYFG 154
Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
KI+ +E+ + L E+ G FLVRES G Y L VS G +V HY++ D G
Sbjct: 155 KITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGG 214
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKL--VRPKRKHGTKSAEEELARAGWLLNLQHL 236
I F +L +V +YSK +C +L V P K T+ LA+ W + + L
Sbjct: 215 FYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG----LAKDAWEIPRESL 270
Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
L ++G+G FG V G + G +VA+K +K ++ +AFL E VM K++HE LV+L
Sbjct: 271 RLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330
Query: 295 VILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL 354
V+ + +YIV E++SKG+L++FL+ + QL+ + +A GM Y+E VHRDL
Sbjct: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390
Query: 355 AARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWS 410
A NILV E+LV KV+DFGLA+ E ++ P+KWTAPEA +G+FT KSDVWS
Sbjct: 391 RAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 450
Query: 411 FGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470
FG+LL E+ + GR PYP M +EV + VE+GYRM P CP +H LM CW EP RP
Sbjct: 451 FGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP 510
Query: 471 PFRKL 475
F L
Sbjct: 511 TFEYL 515
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 271 bits (694), Expect = 8e-73
Identities = 159/427 (37%), Positives = 240/427 (56%), Gaps = 25/427 (5%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L+F+KGD + +LE E+ W++ + + +EG + + + ++L + WF
Sbjct: 96 DLSFQKGDQMVVLE--ESGEWWKARSLATRKEGYIPSNYVARVDSLETEE------WFFK 147
Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
IS ++A +QL P + G F++R+S G Y L V G V HY++ D G
Sbjct: 148 GISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGG 207
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
I F L ++V+HY K +C KL P + E+ A W + + L L
Sbjct: 208 FYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDA---WEIPRESLKL 264
Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKC-DVTAQAFLDETAVMTKMQHENLVRLLGVI 296
++G G+FG V Y KVAVK +K ++ +AFL E VM +QH+ LV+L V+
Sbjct: 265 EKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVV 324
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
+ +YI+ E ++KG+L++FL++ + +L+ FS +AEGM ++E + +HRDL A
Sbjct: 325 TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRA 384
Query: 357 RNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFG 412
NILVS LV K++DFGLA+ E + ++ P+KWTAPEA+ G FT KSDVWSFG
Sbjct: 385 ANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFG 444
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
+LL E+ +YGR PYP MS EV A+E+GYRM PE CP ++ +M CW+ P RP F
Sbjct: 445 ILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTF 504
Query: 473 RKLAEKL 479
+ L
Sbjct: 505 EYIQSVL 511
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 268 bits (686), Expect = 7e-72
Identities = 158/422 (37%), Positives = 240/422 (56%), Gaps = 27/422 (6%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L+F+KG+ I+ E W+ + +G+ G + + + +++ A+ W+ G
Sbjct: 109 DLSFKKGERFQIINNTEG-DWWEARSIATGKNGYIPSNYVAPADSIQAEE------WYFG 161
Query: 127 KISGQEAVQQLQPP--EDGLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
K+ ++A + L P + G+FLVRES G Y L + G +V HY++ D G
Sbjct: 162 KMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGG 221
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKL--VRPKRKHGTKSAEEELARAGWLLNLQHL 236
I F L +V+HY++ +C KL V P K T+ LA+ W + + L
Sbjct: 222 YYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQG----LAKDAWEIPRESL 277
Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
L ++G+G FG V G + G KVA+K +K + +AFL E +M K++H+ LV L
Sbjct: 278 RLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYA 337
Query: 295 VILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL 354
V+ + +YIV E +SKG+L++FL+ + QL+ + +A+GM Y+E +HRDL
Sbjct: 338 VVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDL 397
Query: 355 AARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWS 410
A NILV E+LV K++DFGLA+ E ++ P+KWTAPEA +G+FT KSDVWS
Sbjct: 398 RAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 457
Query: 411 FGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470
FG+L E+ + GR PYP M +EV E VE+GYRM P+GCP +H LM+ CW+ +P RP
Sbjct: 458 FGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERP 517
Query: 471 PF 472
F
Sbjct: 518 TF 519
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 264 bits (674), Expect = 2e-70
Identities = 156/425 (36%), Positives = 242/425 (56%), Gaps = 24/425 (5%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L+F KG+ IL + E W+ + T+G+ G + + + +++ A+ W+ G
Sbjct: 100 DLSFHKGEKFQILNSSEG-DWWEARSLTTGETGYIPSNYVAPVDSIQAEE------WYFG 152
Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
K+ ++A +QL + G FL+RES G Y L + G V HY++ D G
Sbjct: 153 KLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGG 212
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEEL-ARAGWLLNLQHLT 237
I F L +V+HYS+ +C +LV P K + + + + W + + L
Sbjct: 213 YYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQ 272
Query: 238 LGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGV 295
L ++G G+FG V G + G KVA+K +K ++ ++FL+E +M K++H+ LV+L V
Sbjct: 273 LIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAV 332
Query: 296 ILHQGLYIVMEHVSKGNLVNFLRT-RGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL 354
+ + +YIV E+++KG+L++FL+ GRAL L+ + VA GM Y+E +HRDL
Sbjct: 333 VSEEPIYIVTEYMNKGSLLDFLKDGEGRAL-KLPNLVDMAAQVAAGMAYIERMNYIHRDL 391
Query: 355 AARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWS 410
+ NILV L+ K++DFGLA+ E ++ P+KWTAPEA +G+FT KSDVWS
Sbjct: 392 RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 451
Query: 411 FGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470
FG+LL E+ + GR PYP M+ +EV E VE+GYRM P+ CP +H LM CW+ +P RP
Sbjct: 452 FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERP 511
Query: 471 PFRKL 475
F L
Sbjct: 512 TFEYL 516
>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
Length = 822
Score = 264 bits (674), Expect = 2e-70
Identities = 162/418 (38%), Positives = 239/418 (57%), Gaps = 26/418 (6%)
Query: 76 VTILEACENKSWYR-VKHHTSG----QEGLLAAGALREREALSADPKLSLMPWFHGKISG 130
VT +E E S + ++H +G + L + AL + ++S P L+ W+HG I
Sbjct: 409 VTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKP-LAEQDWYHGAIPR 467
Query: 131 QEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNL 190
EA + L+ + G FLVRES PG+YVL V H+ + + D E F N+
Sbjct: 468 IEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRF-EGTGFSNI 524
Query: 191 MDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAV 250
+++H+ K I +K G W+L+ + + LG +G+G FG V
Sbjct: 525 PQLIDHHYTTKQVIT-------KKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEV 577
Query: 251 LQGEYLGQ-KVAVKNIKCDVTAQA---FLDETAVMTKMQHENLVRLLGVILH-QGLYIVM 305
+G + VAVK K D+ + FL E ++ + H N+V+L+GV Q +YI+M
Sbjct: 578 YKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIM 637
Query: 306 EHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDL 365
E VS G+ + FLR R + + QL++FSL A GM YLESK +HRDLAARN LV E+
Sbjct: 638 ELVSGGDFLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENN 696
Query: 366 VAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY 421
V K+SDFG+++ E G+ SS ++P+KWTAPEAL +G+++S+SDVWSFG+LLWE FS
Sbjct: 697 VLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSL 756
Query: 422 GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 479
G PYP M+ ++ E VE+GYRM P+ CP + +M CW+ +P RP F +L ++L
Sbjct: 757 GVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL 814
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 263 bits (673), Expect = 2e-70
Identities = 152/430 (35%), Positives = 244/430 (56%), Gaps = 26/430 (6%)
Query: 65 PGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWF 124
P +L+F+KG+ + +LE E+ W++ K + +EG + + + + L + WF
Sbjct: 58 PDDLSFKKGEKMKVLE--EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE------WF 109
Query: 125 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVS-----FGRDVIHYRVLHRD- 176
I+ ++A +QL P + G FL+RES G + L V G + HY++ D
Sbjct: 110 FKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDN 169
Query: 177 GHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHL 236
G I + F + DM++HY K +C +L ++ + ++ + W + + +
Sbjct: 170 GGYYISPRITFPCISDMIKHYQKQADGLCRRL---EKACISPKPQKPWDKDAWEIPRESI 226
Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
L ++G G+FG V G Y KVAVK +K ++ QAFL+E +M +QH+ LVRL
Sbjct: 227 KLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYA 286
Query: 295 VILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRD 353
V+ + +YI+ E+++KG+L++FL++ V +L+ FS +AEGM Y+E K +HRD
Sbjct: 287 VVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRD 346
Query: 354 LAARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVW 409
L A N+LVSE L+ K++DFGLA+ E + ++ P+KWTAPEA+ G FT KSDVW
Sbjct: 347 LRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVW 406
Query: 410 SFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARR 469
SFG+LL+E+ +YG+ PYP + +V A+ +GYRM E CP ++ +M CW+ + R
Sbjct: 407 SFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEER 466
Query: 470 PPFRKLAEKL 479
P F L L
Sbjct: 467 PTFDYLQSVL 476
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 263 bits (673), Expect = 2e-70
Identities = 152/430 (35%), Positives = 244/430 (56%), Gaps = 26/430 (6%)
Query: 65 PGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWF 124
P +L+F+KG+ + +LE E+ W++ K + +EG + + + + L + WF
Sbjct: 79 PDDLSFKKGEKMKVLE--EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE------WF 130
Query: 125 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVS-----FGRDVIHYRVLHRD- 176
I+ ++A +QL P + G FL+RES G + L V G + HY++ D
Sbjct: 131 FKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDN 190
Query: 177 GHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHL 236
G I + F + DM++HY K +C +L ++ + ++ + W + + +
Sbjct: 191 GGYYISPRITFPCISDMIKHYQKQADGLCRRL---EKACISPKPQKPWDKDAWEIPRESI 247
Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
L ++G G+FG V G Y KVAVK +K ++ QAFL+E +M +QH+ LVRL
Sbjct: 248 KLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYA 307
Query: 295 VILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRD 353
V+ + +YI+ E+++KG+L++FL++ V +L+ FS +AEGM Y+E K +HRD
Sbjct: 308 VVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRD 367
Query: 354 LAARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVW 409
L A N+LVSE L+ K++DFGLA+ E + ++ P+KWTAPEA+ G FT KSDVW
Sbjct: 368 LRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVW 427
Query: 410 SFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARR 469
SFG+LL+E+ +YG+ PYP + +V A+ +GYRM E CP ++ +M CW+ + R
Sbjct: 428 SFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEER 487
Query: 470 PPFRKLAEKL 479
P F L L
Sbjct: 488 PTFDYLQSVL 497
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 261 bits (667), Expect = 1e-69
Identities = 162/453 (35%), Positives = 243/453 (53%), Gaps = 41/453 (9%)
Query: 68 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
L+ KG+ + +L +N W V+ + +G + + + +L W+HG
Sbjct: 111 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 162
Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
+S A L +G FLVRES PG + + + V HYR+ DG + +
Sbjct: 163 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 222
Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
F L ++V H+S + T L P K +G ++ W + +T+
Sbjct: 223 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 277
Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
++G G++G V G + VAVK +K D + + FL E AVM +++H NLV+LLGV
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
L YIV E++ GNL+++LR R V LL + ++ MEYLE K +HRDLAA
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397
Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
RN LV E+ V KV+DFGL++ ++ + P+KWTAPE+L + F+ KSDVW+FG
Sbjct: 398 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP V+ LM +CW+ PA RP F
Sbjct: 458 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517
Query: 473 RK-------------LAEKLARELRSAGAPASV 492
+ ++E++A EL A + +SV
Sbjct: 518 AETHQAFETMFHDSSISEEVAEELGRAASSSSV 550
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 261 bits (667), Expect = 1e-69
Identities = 162/453 (35%), Positives = 243/453 (53%), Gaps = 41/453 (9%)
Query: 68 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
L+ KG+ + +L +N W V+ + +G + + + +L W+HG
Sbjct: 126 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 177
Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
+S A L +G FLVRES PG + + + V HYR+ DG + +
Sbjct: 178 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 237
Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
F L ++V H+S + T L P K +G ++ W + +T+
Sbjct: 238 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 292
Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
++G G++G V G + VAVK +K D + + FL E AVM +++H NLV+LLGV
Sbjct: 293 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 352
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
L YIV E++ GNL+++LR R V LL + ++ MEYLE K +HRDLAA
Sbjct: 353 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412
Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
RN LV E+ V KV+DFGL++ ++ + P+KWTAPE+L + F+ KSDVW+FG
Sbjct: 413 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 472
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP V+ LM +CW+ PA RP F
Sbjct: 473 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532
Query: 473 RK-------------LAEKLARELRSAGAPASV 492
+ ++E++A EL A + +SV
Sbjct: 533 AETHQAFETMFHDSSISEEVAEELGRAASSSSV 565
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 261 bits (667), Expect = 1e-69
Identities = 162/453 (35%), Positives = 243/453 (53%), Gaps = 41/453 (9%)
Query: 68 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
L+ KG+ + +L +N W V+ + +G + + + +L W+HG
Sbjct: 111 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 162
Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
+S A L +G FLVRES PG + + + V HYR+ DG + +
Sbjct: 163 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 222
Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
F L ++V H+S + T L P K +G ++ W + +T+
Sbjct: 223 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 277
Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
++G G++G V G + VAVK +K D + + FL E AVM +++H NLV+LLGV
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
L YIV E++ GNL+++LR R V LL + ++ MEYLE K +HRDLAA
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397
Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
RN LV E+ V KV+DFGL++ ++ + P+KWTAPE+L + F+ KSDVW+FG
Sbjct: 398 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP V+ LM +CW+ PA RP F
Sbjct: 458 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517
Query: 473 RK-------------LAEKLARELRSAGAPASV 492
+ ++E++A EL A + +SV
Sbjct: 518 AETHQAFETMFHDSSISEEVAEELGRAASSSSV 550
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 261 bits (667), Expect = 1e-69
Identities = 162/453 (35%), Positives = 243/453 (53%), Gaps = 41/453 (9%)
Query: 68 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
L+ KG+ + +L +N W V+ + +G + + + +L W+HG
Sbjct: 90 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 141
Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
+S A L +G FLVRES PG + + + V HYR+ DG + +
Sbjct: 142 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 201
Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
F L ++V H+S + T L P K +G ++ W + +T+
Sbjct: 202 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 256
Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
++G G++G V G + VAVK +K D + + FL E AVM +++H NLV+LLGV
Sbjct: 257 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 316
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
L YIV E++ GNL+++LR R V LL + ++ MEYLE K +HRDLAA
Sbjct: 317 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 376
Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
RN LV E+ V KV+DFGL++ ++ + P+KWTAPE+L + F+ KSDVW+FG
Sbjct: 377 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 436
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP V+ LM +CW+ PA RP F
Sbjct: 437 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 496
Query: 473 RK-------------LAEKLARELRSAGAPASV 492
+ ++E++A EL A + +SV
Sbjct: 497 AETHQAFETMFHDSSISEEVAEELGRAASSSSV 529
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 261 bits (666), Expect = 1e-69
Identities = 159/434 (36%), Positives = 244/434 (56%), Gaps = 24/434 (5%)
Query: 59 EHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKL 118
++T +L KG+ + +L+ + W+ + +G+EG + + + E+L +
Sbjct: 68 DYTAMNDRDLQMLKGEKLQVLKGTGD--WWLARSLVTGREGYVPSNFVARVESLEMER-- 123
Query: 119 SLMPWFHGKISGQEAVQQLQPP--EDGLFLVRESARHPGDYVLCV----SFGRDVIHYRV 172
WF +EA +QL P + G FL+RES + G + L V + G + HY++
Sbjct: 124 ----WFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKI 179
Query: 173 LHRD-GHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLL 231
D G I + F +L +V+HYSK +C +L P + + + A+ W +
Sbjct: 180 RCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVR---PAPQNPWAQDEWEI 236
Query: 232 NLQHLTLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIK-CDVTAQAFLDETAVMTKMQHENL 289
Q L L ++G G+FG V G Y KVA+K +K ++ +AFL E VM +QHE L
Sbjct: 237 PRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERL 296
Query: 290 VRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKL 349
VRL V+ + +YIV E++++G L++FL+T + ++ +L+ S +AEGM Y+E
Sbjct: 297 VRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNS 356
Query: 350 VHRDLAARNILVSEDLVAKVSDFGLAK---AERKGLDSSRLPVKWTAPEALKHGKFTSKS 406
+HRDL A NILVSE L K++DFGLA+ +E + ++ P+KWTAPEA+ G FT K+
Sbjct: 357 IHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKA 416
Query: 407 DVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVH-VLMSSCWEAE 465
DVWSFGVLL EV +YGR PYP MS EV +E+GYRM P+ CP ++ +++ CW +
Sbjct: 417 DVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSR 476
Query: 466 PARRPPFRKLAEKL 479
P RP F L L
Sbjct: 477 PEERPTFEFLQSVL 490
>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
Length = 451
Score = 261 bits (666), Expect = 1e-69
Identities = 164/426 (38%), Positives = 240/426 (56%), Gaps = 21/426 (4%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQ--EGLLAAGALREREALSADPKLSLMPWF 124
EL+FR GDV + E W + G +G + L ERE + ++P WF
Sbjct: 26 ELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEP------WF 79
Query: 125 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSFGRDVIHYRVLHR-DGHLTI 181
G IS EAV++LQ + G FL+R S + DYVL V + V HY++ R G L +
Sbjct: 80 FGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHL 139
Query: 182 DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ 241
+EAV F +L ++V ++ + +L P RKH + W + TL +
Sbjct: 140 NEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHW---DDWERPREEFTLCRK 196
Query: 242 IGEGEFGAVLQGEYLGQ-KVAVKNIKCD--VTAQAFLDETAVMTKMQHENLVRLLGVI-L 297
+G G FG V +G + + +VA+K I D + Q E M K++H++++ L V+ +
Sbjct: 197 LGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSV 256
Query: 298 HQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAAR 357
+YI+ E ++KG+L+ LR ++ ++LL + VAEGM YLES+ +HRDLAAR
Sbjct: 257 GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAAR 316
Query: 358 NILVSEDLVAKVSDFGLAKAERKGLDSSR---LPVKWTAPEALKHGKFTSKSDVWSFGVL 414
NILV E+ + KV DFGLA+ ++ + S +P KWTAPEAL G +++KSDVWSFG+L
Sbjct: 317 NILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGIL 376
Query: 415 LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK 474
L E+FS G+ PYP MS E V+ GYRM P CP VH LM +CW +P +RP F+
Sbjct: 377 LHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKA 436
Query: 475 LAEKLA 480
L E+L+
Sbjct: 437 LRERLS 442
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 259 bits (662), Expect = 4e-69
Identities = 158/449 (35%), Positives = 239/449 (53%), Gaps = 31/449 (6%)
Query: 68 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
L+ KG+ + +L N W + T +G + + + +L W+HG
Sbjct: 80 LSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSLEKHS------WYHGP 131
Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
+S A L +G FLVRES PG + + + V HYR+ DG L +
Sbjct: 132 VSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESR 191
Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAG-WLLNLQHLTLGAQIGEG 245
F L ++V H+S + T L P K + W + +T+ ++G G
Sbjct: 192 FNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGG 251
Query: 246 EFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVILHQG-L 301
++G V +G + VAVK +K D + + FL E AVM +++H NLV+LLGV +
Sbjct: 252 QYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF 311
Query: 302 YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV 361
YI+ E ++ GNL+++LR R VN LL + ++ MEYLE K +HRDLAARN LV
Sbjct: 312 YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 371
Query: 362 SEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWE 417
E+ + KV+DFGL++ ++ + P+KWTAPE+L + KF+ KSDVW+FGVLLWE
Sbjct: 372 GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWE 431
Query: 418 VFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK--- 474
+ +YG +PYP + L +V E +EK YRME PEGCP V+ LM +CW+ P+ RP F +
Sbjct: 432 IATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 491
Query: 475 ----------LAEKLARELRSAGAPASVS 493
+++++ +EL G +VS
Sbjct: 492 AFETMFQESSISDEVEKELGKQGVRGAVS 520
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 259 bits (662), Expect = 4e-69
Identities = 158/449 (35%), Positives = 239/449 (53%), Gaps = 31/449 (6%)
Query: 68 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
L+ KG+ + +L N W + T +G + + + +L W+HG
Sbjct: 99 LSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSLEKHS------WYHGP 150
Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
+S A L +G FLVRES PG + + + V HYR+ DG L +
Sbjct: 151 VSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESR 210
Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAG-WLLNLQHLTLGAQIGEG 245
F L ++V H+S + T L P K + W + +T+ ++G G
Sbjct: 211 FNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGG 270
Query: 246 EFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVILHQG-L 301
++G V +G + VAVK +K D + + FL E AVM +++H NLV+LLGV +
Sbjct: 271 QYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF 330
Query: 302 YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV 361
YI+ E ++ GNL+++LR R VN LL + ++ MEYLE K +HRDLAARN LV
Sbjct: 331 YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 390
Query: 362 SEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWE 417
E+ + KV+DFGL++ ++ + P+KWTAPE+L + KF+ KSDVW+FGVLLWE
Sbjct: 391 GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWE 450
Query: 418 VFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK--- 474
+ +YG +PYP + L +V E +EK YRME PEGCP V+ LM +CW+ P+ RP F +
Sbjct: 451 IATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 510
Query: 475 ----------LAEKLARELRSAGAPASVS 493
+++++ +EL G +VS
Sbjct: 511 AFETMFQESSISDEVEKELGKQGVRGAVS 539
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 259 bits (661), Expect = 5e-69
Identities = 160/434 (36%), Positives = 235/434 (54%), Gaps = 23/434 (5%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L F KG+ IL E W+ + +SG+ G + + + +++ A+ W+ G
Sbjct: 95 DLTFTKGEKFHILNNTEG-DWWEARSLSSGKTGCIPSNYVAPVDSIQAEE------WYFG 147
Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-GH 178
KI ++A +QL P + G FL+RES G Y L + + G V HY++ D G
Sbjct: 148 KIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGG 207
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
I V F ++ ++V+HY + +C L+ P K LA+ W ++ +TL
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTI--MKPQTLGLAKDAWEISRSSITL 265
Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI 296
++G G FG V G + G KVAVK +K ++ +AFL+E VM ++H+ LV+L V+
Sbjct: 266 ERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV 325
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
+ +YIV E + G+L++FL+ + QL+ + VAEGM Y+E +HRDL A
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385
Query: 357 RNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFG 412
NILV E L K++DFGLA+ E S+ P+KWTAPEA G+FT KSDVWSFG
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFG 445
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
+LL E+ + GR PYP M+ +EV E VE+GY M P GCP ++ M W +P RP F
Sbjct: 446 ILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTF 505
Query: 473 RKLAEKLARELRSA 486
L L SA
Sbjct: 506 EYLQSFLEDYFTSA 519
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 259 bits (661), Expect = 5e-69
Identities = 160/434 (36%), Positives = 235/434 (54%), Gaps = 23/434 (5%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L F KG+ IL E W+ + +SG+ G + + + +++ A+ W+ G
Sbjct: 95 DLTFTKGEKFHILNNTEG-DWWEARSLSSGKTGCIPSNYVAPVDSIQAEE------WYFG 147
Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-GH 178
KI ++A +QL P + G FL+RES G Y L + + G V HY++ D G
Sbjct: 148 KIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGG 207
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
I V F ++ ++V+HY + +C L+ P K LA+ W ++ +TL
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTI--MKPQTLGLAKDAWEISRSSITL 265
Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI 296
++G G FG V G + G KVAVK +K ++ +AFL+E VM ++H+ LV+L V+
Sbjct: 266 ERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV 325
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
+ +YIV E + G+L++FL+ + QL+ + VAEGM Y+E +HRDL A
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385
Query: 357 RNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFG 412
NILV E L K++DFGLA+ E S+ P+KWTAPEA G+FT KSDVWSFG
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFG 445
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
+LL E+ + GR PYP M+ +EV E VE+GY M P GCP ++ M W +P RP F
Sbjct: 446 ILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTF 505
Query: 473 RKLAEKLARELRSA 486
L L SA
Sbjct: 506 EYLQSFLEDYFTSA 519
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 259 bits (661), Expect = 5e-69
Identities = 160/434 (36%), Positives = 235/434 (54%), Gaps = 23/434 (5%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L F KG+ IL E W+ + +SG+ G + + + +++ A+ W+ G
Sbjct: 95 DLTFTKGEKFHILNNTEG-DWWEARSLSSGKTGCIPSNYVAPVDSIQAEE------WYFG 147
Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-GH 178
KI ++A +QL P + G FL+RES G Y L + + G V HY++ D G
Sbjct: 148 KIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGG 207
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
I V F ++ ++V+HY + +C L+ P K LA+ W ++ +TL
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTI--MKPQTLGLAKDAWEISRSSITL 265
Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI 296
++G G FG V G + G KVAVK +K ++ +AFL+E VM ++H+ LV+L V+
Sbjct: 266 ERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV 325
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
+ +YIV E + G+L++FL+ + QL+ + VAEGM Y+E +HRDL A
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385
Query: 357 RNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFG 412
NILV E L K++DFGLA+ E S+ P+KWTAPEA G+FT KSDVWSFG
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFG 445
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
+LL E+ + GR PYP M+ +EV E VE+GY M P GCP ++ M W +P RP F
Sbjct: 446 ILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTF 505
Query: 473 RKLAEKLARELRSA 486
L L SA
Sbjct: 506 EYLQSFLEDYFTSA 519
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 258 bits (658), Expect = 1e-68
Identities = 155/420 (36%), Positives = 229/420 (54%), Gaps = 28/420 (6%)
Query: 68 LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
L+ KG+ + +L +N W V+ + +G + + + +L W+HG
Sbjct: 105 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 156
Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
+S A L +G FLVRES PG + + + V HYR+ DG + +
Sbjct: 157 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 216
Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
F L ++V H+S + T L P K +G ++ W + +T+
Sbjct: 217 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 271
Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
++G G++G V G + VAVK +K D + + FL E AVM +++H NLV+LLGV
Sbjct: 272 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 331
Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
L YIV E++ GNL+++LR R V LL + ++ MEYLE K +HRDLAA
Sbjct: 332 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 391
Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
RN LV E+ V KV+DFGL++ ++ + P+KWTAPE+L + F+ KSDVW+FG
Sbjct: 392 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 451
Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP V+ LM +CW+ PA RP F
Sbjct: 452 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 511
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 255 bits (652), Expect = 6e-68
Identities = 154/424 (36%), Positives = 239/424 (56%), Gaps = 25/424 (5%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
+L+F KG+ IL + E W+ + T+G+ G + + + +++ A+ W+ G
Sbjct: 100 DLSFHKGEKFQILNSSEG-DWWEARSLTTGETGYIPSNYVAPVDSIQAEE------WYFG 152
Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
K+ ++A +QL + G FL+RES G Y L + G V HY++ D G
Sbjct: 153 KLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGG 212
Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
I F L +V+HYS+ +C L +++ LA+ W + + L L
Sbjct: 213 YYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSG--LAKDAWEVARRSLCL 270
Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI 296
++G+G F V G + G KVA+K +K ++ ++FL+E +M K++H+ LV+L V+
Sbjct: 271 EKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVV 330
Query: 297 LHQGLYIVMEHVSKGNLVNFLRT-RGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355
+ +YIV E+++KG+L++FL+ GRAL L+ + VA GM Y+E +HRDL
Sbjct: 331 SEEPIYIVTEYMNKGSLLDFLKDGEGRAL-KLPNLVDMAAQVAAGMAYIERMNYIHRDLR 389
Query: 356 ARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSF 411
+ NILV L+ K++DFGLA+ E ++ P+KWTAPEA +G+FT KSDVWSF
Sbjct: 390 SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 449
Query: 412 GVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPP 471
G+LL E+ + GR PYP M+ +EV E VE+GYRM P+ CP +H LM CW+ +P RP
Sbjct: 450 GILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPT 509
Query: 472 FRKL 475
F L
Sbjct: 510 FEYL 513
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 255 bits (651), Expect = 8e-68
Identities = 171/426 (40%), Positives = 232/426 (54%), Gaps = 25/426 (5%)
Query: 66 GELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPK-LSLMPWF 124
GEL+ R+GD + LE Y SGQ +AG + A P+ LS PW+
Sbjct: 68 GELSVRRGDRLCALE---EGGGYIFARRLSGQP---SAGLVPITHVAKASPETLSDQPWY 121
Query: 125 HGKISGQEAVQQLQPP--EDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTI 181
+S +A Q L P E G FL+R S G Y L V V HYRV + DG L +
Sbjct: 122 FSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYL 181
Query: 182 DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ 241
+ F L +++ +Y + I L++P K+ +++ W LG +
Sbjct: 182 QKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQ--KAPRQDV----WERPHSEFALGRK 235
Query: 242 IGEGEFGAVLQGEYLGQ-KVAVKNIK-CDVTAQAFLDETAVMTKMQHENLVRLLGVILH- 298
+GEG FG V +G +LG VA+K IK ++ E + ++HE L+RL V
Sbjct: 236 LGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGG 295
Query: 299 QGLYIVMEHVSKGNLVNFLRT-RGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAAR 357
+ +YIV E + KGNL FL T GRAL LL F+ VAEGM YLE +++VHRDLAAR
Sbjct: 296 EPVYIVTELMRKGNLQAFLGTPEGRAL-RLPPLLGFACQVAEGMSYLEEQRVVHRDLAAR 354
Query: 358 NILVSEDLVAKVSDFGLAKAERKGL----DSSRLPVKWTAPEALKHGKFTSKSDVWSFGV 413
N+LV + L KV+DFGLA+ + + SS++PVKWTAPEA + F+ KSDVWSFGV
Sbjct: 355 NVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGV 414
Query: 414 LLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFR 473
LL EVF+YG+ PY M+ E + + +GYR+ P CP V+VLM CW + P RP F
Sbjct: 415 LLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFA 474
Query: 474 KLAEKL 479
L EKL
Sbjct: 475 TLREKL 480
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 245 bits (626), Expect = 6e-65
Identities = 152/431 (35%), Positives = 233/431 (54%), Gaps = 21/431 (4%)
Query: 67 ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR---EREALSADPKLSLMPW 123
+L+FR GD + +L+ ++ W+ +H ++G ++ L+ ++ D L PW
Sbjct: 60 DLSFRAGDKLQVLDTL-HEGWWFARHLEKRRDG--SSQQLQGYIPSNYVAEDRSLQAEPW 116
Query: 124 FHGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRD-GHLT 180
F G I +A +QL E+ G FL+RES G++ L V G V HYR+ D G
Sbjct: 117 FFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFF 176
Query: 181 IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA--GWLLNLQHLTL 238
+ F L + V HY+K +C KL +P K + + + W ++ + L
Sbjct: 177 LTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQL 236
Query: 239 GAQIGEGEFGAVLQGEYLGQK-VAVKNIKC-DVTAQAFLDETAVMTKMQHENLVRLLGVI 296
++G G+FG V +G + VAVK +K + FL E +M ++H L++L V
Sbjct: 237 LKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVC 296
Query: 297 -LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355
L +YI+ E + G+L +L+ + ++ Q + + VA GM YLES+ +HRDLA
Sbjct: 297 TLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLA 356
Query: 356 ARNILVSEDLVAKVSDFGLA---KAERKGLDSSR----LPVKWTAPEALKHGKFTSKSDV 408
ARN+LV E + KV+DFGLA K + + + SR LPVKWTAPEA++ KF+ KSDV
Sbjct: 357 ARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDV 416
Query: 409 WSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPAR 468
WSFG+LL+E+ +YG+ PY M+ +V + + + YR+ P CP + +M CW AEP
Sbjct: 417 WSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKE 476
Query: 469 RPPFRKLAEKL 479
RP F L KL
Sbjct: 477 RPTFETLRWKL 487
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,310,293
Number of Sequences: 37866
Number of extensions: 1035329
Number of successful extensions: 4868
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 650
Number of HSP's successfully gapped in prelim test: 306
Number of HSP's that attempted gapping in prelim test: 2763
Number of HSP's gapped (non-prelim): 1153
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.