Guide to the Human Genome
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Search of human proteins with 21450842

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
         (508 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [...  1034   0.0  
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [...   983   0.0  
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [...   946   0.0  
gi|187475373 c-src tyrosine kinase [Homo sapiens]                     483   e-136
gi|4758078 c-src tyrosine kinase [Homo sapiens]                       483   e-136
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs...   282   6e-76
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs...   282   6e-76
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap...   273   4e-73
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi...   273   4e-73
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]     271   8e-73
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]              268   7e-72
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]       264   2e-70
gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]     264   2e-70
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ...   263   2e-70
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is...   263   2e-70
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]             261   1e-69
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]               261   1e-69
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]             261   1e-69
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]             261   1e-69
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]                 261   1e-69
gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]              261   1e-69
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a...   259   4e-69
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b...   259   4e-69
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   259   5e-69
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa...   259   5e-69
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi...   259   5e-69
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]             258   1e-68
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]      255   6e-68
gi|18250298 src-related kinase lacking C-terminal regulatory tyr...   255   8e-68
gi|4503787 fyn-related kinase [Homo sapiens]                          245   6e-65

>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
           [Homo sapiens]
          Length = 508

 Score = 1034 bits (2674), Expect = 0.0
 Identities = 508/508 (100%), Positives = 508/508 (100%)

Query: 1   MQGHFPAERREGRPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEH 60
           MQGHFPAERREGRPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEH
Sbjct: 1   MQGHFPAERREGRPRRGTRGQQQLLVSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEH 60

Query: 61  TRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSL 120
           TRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSL
Sbjct: 61  TRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSL 120

Query: 121 MPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLT 180
           MPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLT
Sbjct: 121 MPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLT 180

Query: 181 IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGA 240
           IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGA
Sbjct: 181 IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGA 240

Query: 241 QIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG 300
           QIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG
Sbjct: 241 QIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQG 300

Query: 301 LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL 360
           LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL
Sbjct: 301 LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNIL 360

Query: 361 VSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS 420
           VSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS
Sbjct: 361 VSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFS 420

Query: 421 YGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLA 480
           YGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLA
Sbjct: 421 YGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLA 480

Query: 481 RELRSAGAPASVSGQDADGSTSPRSQEP 508
           RELRSAGAPASVSGQDADGSTSPRSQEP
Sbjct: 481 RELRSAGAPASVSGQDADGSTSPRSQEP 508


>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
           [Homo sapiens]
          Length = 507

 Score =  983 bits (2540), Expect = 0.0
 Identities = 483/483 (100%), Positives = 483/483 (100%)

Query: 26  VSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENK 85
           VSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENK
Sbjct: 25  VSPRFLRAWHPPPVSARMPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENK 84

Query: 86  SWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLF 145
           SWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLF
Sbjct: 85  SWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLF 144

Query: 146 LVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAIC 205
           LVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAIC
Sbjct: 145 LVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAIC 204

Query: 206 TKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI 265
           TKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI
Sbjct: 205 TKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNI 264

Query: 266 KCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALV 325
           KCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALV
Sbjct: 265 KCDVTAQAFLDETAVMTKMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALV 324

Query: 326 NTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS 385
           NTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS
Sbjct: 325 NTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSS 384

Query: 386 RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRME 445
           RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRME
Sbjct: 385 RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRME 444

Query: 446 PPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRS 505
           PPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRS
Sbjct: 445 PPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRS 504

Query: 506 QEP 508
           QEP
Sbjct: 505 QEP 507


>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
           [Homo sapiens]
          Length = 466

 Score =  946 bits (2444), Expect = 0.0
 Identities = 466/466 (100%), Positives = 466/466 (100%)

Query: 43  MPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLA 102
           MPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLA
Sbjct: 1   MPTRRWAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLA 60

Query: 103 AGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVS 162
           AGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVS
Sbjct: 61  AGALREREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVS 120

Query: 163 FGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEE 222
           FGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEE
Sbjct: 121 FGRDVIHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEE 180

Query: 223 ELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMT 282
           ELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMT
Sbjct: 181 ELARAGWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMT 240

Query: 283 KMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 342
           KMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME
Sbjct: 241 KMQHENLVRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGME 300

Query: 343 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKF 402
           YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKF
Sbjct: 301 YLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKF 360

Query: 403 TSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCW 462
           TSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCW
Sbjct: 361 TSKSDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCW 420

Query: 463 EAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP 508
           EAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP
Sbjct: 421 EAEPARRPPFRKLAEKLARELRSAGAPASVSGQDADGSTSPRSQEP 466


>gi|187475373 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  483 bits (1242), Expect = e-136
 Identities = 235/434 (54%), Positives = 316/434 (72%), Gaps = 3/434 (0%)

Query: 48  WAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR 107
           W  GT+CI K         +L F KGDV+TI+   ++ +WY+ K+   G+EG++ A  ++
Sbjct: 8   WPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQ 66

Query: 108 EREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDV 167
           +RE + A  KLSLMPWFHGKI+ ++A + L PPE GLFLVRES  +PGDY LCVS    V
Sbjct: 67  KREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKV 126

Query: 168 IHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA 227
            HYR+++    L+IDE V+F NLM +VEHY+ D   +CT+L++PK   GT +A++E  R+
Sbjct: 127 EHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186

Query: 228 GWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHE 287
           GW LN++ L L   IG+GEFG V+ G+Y G KVAVK IK D TAQAFL E +VMT+++H 
Sbjct: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHS 246

Query: 288 NLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE 345
           NLV+LLGVI+ +  GLYIV E+++KG+LV++LR+RGR+++    LL+FSL V E MEYLE
Sbjct: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306

Query: 346 SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSK 405
               VHRDLAARN+LVSED VAKVSDFGL K      D+ +LPVKWTAPEAL+  KF++K
Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366

Query: 406 SDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAE 465
           SDVWSFG+LLWE++S+GR PYP++ LK+V   VEKGY+M+ P+GCP  V+ +M +CW  +
Sbjct: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 426

Query: 466 PARRPPFRKLAEKL 479
            A RP F +L E+L
Sbjct: 427 AAMRPSFLQLREQL 440


>gi|4758078 c-src tyrosine kinase [Homo sapiens]
          Length = 450

 Score =  483 bits (1242), Expect = e-136
 Identities = 235/434 (54%), Positives = 316/434 (72%), Gaps = 3/434 (0%)

Query: 48  WAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR 107
           W  GT+CI K         +L F KGDV+TI+   ++ +WY+ K+   G+EG++ A  ++
Sbjct: 8   WPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQ 66

Query: 108 EREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDV 167
           +RE + A  KLSLMPWFHGKI+ ++A + L PPE GLFLVRES  +PGDY LCVS    V
Sbjct: 67  KREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKV 126

Query: 168 IHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA 227
            HYR+++    L+IDE V+F NLM +VEHY+ D   +CT+L++PK   GT +A++E  R+
Sbjct: 127 EHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186

Query: 228 GWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHE 287
           GW LN++ L L   IG+GEFG V+ G+Y G KVAVK IK D TAQAFL E +VMT+++H 
Sbjct: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHS 246

Query: 288 NLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE 345
           NLV+LLGVI+ +  GLYIV E+++KG+LV++LR+RGR+++    LL+FSL V E MEYLE
Sbjct: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306

Query: 346 SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSK 405
               VHRDLAARN+LVSED VAKVSDFGL K      D+ +LPVKWTAPEAL+  KF++K
Sbjct: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366

Query: 406 SDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAE 465
           SDVWSFG+LLWE++S+GR PYP++ LK+V   VEKGY+M+ P+GCP  V+ +M +CW  +
Sbjct: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 426

Query: 466 PARRPPFRKLAEKL 479
            A RP F +L E+L
Sbjct: 427 AAMRPSFLQLREQL 440


>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  282 bits (721), Expect = 6e-76
 Identities = 161/428 (37%), Positives = 248/428 (57%), Gaps = 25/428 (5%)

Query: 66  GELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFH 125
           G+L F KG+ + ILE  ++  W++ +  T+GQEG +    + +  +L  +P      WF 
Sbjct: 78  GDLGFEKGEQLRILE--QSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP------WFF 129

Query: 126 GKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-G 177
             +S ++A +QL  P +  G FL+RES    G + L V     + G  V HY++ + D G
Sbjct: 130 KNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNG 189

Query: 178 HLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLT 237
              I   + F  L ++V HY+     +CT+L RP +   T+  ++      W +  + L 
Sbjct: 190 GFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ---TQKPQKPWWEDEWEVPRETLK 246

Query: 238 LGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKC-DVTAQAFLDETAVMTKMQHENLVRLLGV 295
           L  ++G G+FG V  G Y G  KVAVK++K   ++  AFL E  +M ++QH+ LVRL  V
Sbjct: 247 LVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAV 306

Query: 296 ILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355
           +  + +YI+ E++  G+LV+FL+T     +   +LL  +  +AEGM ++E +  +HRDL 
Sbjct: 307 VTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLR 366

Query: 356 ARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSF 411
           A NILVS+ L  K++DFGLA+     E    + ++ P+KWTAPEA+ +G FT KSDVWSF
Sbjct: 367 AANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSF 426

Query: 412 GVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPP 471
           G+LL E+ ++GR PYP M+  EV + +E+GYRM  P+ CP  ++ LM  CW+  P  RP 
Sbjct: 427 GILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPT 486

Query: 472 FRKLAEKL 479
           F  L   L
Sbjct: 487 FDYLRSVL 494


>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
           [Homo sapiens]
          Length = 509

 Score =  282 bits (721), Expect = 6e-76
 Identities = 161/428 (37%), Positives = 248/428 (57%), Gaps = 25/428 (5%)

Query: 66  GELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFH 125
           G+L F KG+ + ILE  ++  W++ +  T+GQEG +    + +  +L  +P      WF 
Sbjct: 78  GDLGFEKGEQLRILE--QSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEP------WFF 129

Query: 126 GKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-G 177
             +S ++A +QL  P +  G FL+RES    G + L V     + G  V HY++ + D G
Sbjct: 130 KNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNG 189

Query: 178 HLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLT 237
              I   + F  L ++V HY+     +CT+L RP +   T+  ++      W +  + L 
Sbjct: 190 GFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ---TQKPQKPWWEDEWEVPRETLK 246

Query: 238 LGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKC-DVTAQAFLDETAVMTKMQHENLVRLLGV 295
           L  ++G G+FG V  G Y G  KVAVK++K   ++  AFL E  +M ++QH+ LVRL  V
Sbjct: 247 LVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAV 306

Query: 296 ILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355
           +  + +YI+ E++  G+LV+FL+T     +   +LL  +  +AEGM ++E +  +HRDL 
Sbjct: 307 VTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLR 366

Query: 356 ARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSF 411
           A NILVS+ L  K++DFGLA+     E    + ++ P+KWTAPEA+ +G FT KSDVWSF
Sbjct: 367 AANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSF 426

Query: 412 GVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPP 471
           G+LL E+ ++GR PYP M+  EV + +E+GYRM  P+ CP  ++ LM  CW+  P  RP 
Sbjct: 427 GILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPT 486

Query: 472 FRKLAEKL 479
           F  L   L
Sbjct: 487 FDYLRSVL 494


>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  273 bits (697), Expect = 4e-73
 Identities = 166/425 (39%), Positives = 242/425 (56%), Gaps = 27/425 (6%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L+F+KG+ + I+   E   W+     ++GQ G + +  +   +++ A+       W+ G
Sbjct: 102 DLSFKKGERLQIVNNTEG-DWWLAHSLSTGQTGYIPSNYVAPSDSIQAEE------WYFG 154

Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
           KI+ +E+ + L   E+  G FLVRES    G Y L VS      G +V HY++   D G 
Sbjct: 155 KITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGG 214

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKL--VRPKRKHGTKSAEEELARAGWLLNLQHL 236
             I     F +L  +V +YSK    +C +L  V P  K  T+     LA+  W +  + L
Sbjct: 215 FYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG----LAKDAWEIPRESL 270

Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
            L  ++G+G FG V  G + G  +VA+K +K   ++ +AFL E  VM K++HE LV+L  
Sbjct: 271 RLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330

Query: 295 VILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL 354
           V+  + +YIV E++SKG+L++FL+      +   QL+  +  +A GM Y+E    VHRDL
Sbjct: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390

Query: 355 AARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWS 410
            A NILV E+LV KV+DFGLA+     E      ++ P+KWTAPEA  +G+FT KSDVWS
Sbjct: 391 RAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 450

Query: 411 FGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470
           FG+LL E+ + GR PYP M  +EV + VE+GYRM  P  CP  +H LM  CW  EP  RP
Sbjct: 451 FGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP 510

Query: 471 PFRKL 475
            F  L
Sbjct: 511 TFEYL 515


>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
           sapiens]
          Length = 536

 Score =  273 bits (697), Expect = 4e-73
 Identities = 166/425 (39%), Positives = 242/425 (56%), Gaps = 27/425 (6%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L+F+KG+ + I+   E   W+     ++GQ G + +  +   +++ A+       W+ G
Sbjct: 102 DLSFKKGERLQIVNNTEG-DWWLAHSLSTGQTGYIPSNYVAPSDSIQAEE------WYFG 154

Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
           KI+ +E+ + L   E+  G FLVRES    G Y L VS      G +V HY++   D G 
Sbjct: 155 KITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGG 214

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKL--VRPKRKHGTKSAEEELARAGWLLNLQHL 236
             I     F +L  +V +YSK    +C +L  V P  K  T+     LA+  W +  + L
Sbjct: 215 FYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQG----LAKDAWEIPRESL 270

Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
            L  ++G+G FG V  G + G  +VA+K +K   ++ +AFL E  VM K++HE LV+L  
Sbjct: 271 RLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYA 330

Query: 295 VILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL 354
           V+  + +YIV E++SKG+L++FL+      +   QL+  +  +A GM Y+E    VHRDL
Sbjct: 331 VVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDL 390

Query: 355 AARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWS 410
            A NILV E+LV KV+DFGLA+     E      ++ P+KWTAPEA  +G+FT KSDVWS
Sbjct: 391 RAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 450

Query: 411 FGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470
           FG+LL E+ + GR PYP M  +EV + VE+GYRM  P  CP  +H LM  CW  EP  RP
Sbjct: 451 FGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERP 510

Query: 471 PFRKL 475
            F  L
Sbjct: 511 TFEYL 515


>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
          Length = 526

 Score =  271 bits (694), Expect = 8e-73
 Identities = 159/427 (37%), Positives = 240/427 (56%), Gaps = 25/427 (5%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L+F+KGD + +LE  E+  W++ +   + +EG + +  +   ++L  +       WF  
Sbjct: 96  DLSFQKGDQMVVLE--ESGEWWKARSLATRKEGYIPSNYVARVDSLETEE------WFFK 147

Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
            IS ++A +QL  P +  G F++R+S    G Y L V       G  V HY++   D G 
Sbjct: 148 GISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYKIRTLDNGG 207

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
             I     F  L ++V+HY K    +C KL  P      +   E+ A   W +  + L L
Sbjct: 208 FYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDA---WEIPRESLKL 264

Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKC-DVTAQAFLDETAVMTKMQHENLVRLLGVI 296
             ++G G+FG V    Y    KVAVK +K   ++ +AFL E  VM  +QH+ LV+L  V+
Sbjct: 265 EKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVV 324

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
             + +YI+ E ++KG+L++FL++   +     +L+ FS  +AEGM ++E +  +HRDL A
Sbjct: 325 TKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRA 384

Query: 357 RNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFG 412
            NILVS  LV K++DFGLA+     E    + ++ P+KWTAPEA+  G FT KSDVWSFG
Sbjct: 385 ANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFG 444

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           +LL E+ +YGR PYP MS  EV  A+E+GYRM  PE CP  ++ +M  CW+  P  RP F
Sbjct: 445 ILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKNRPEERPTF 504

Query: 473 RKLAEKL 479
             +   L
Sbjct: 505 EYIQSVL 511


>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
          Length = 543

 Score =  268 bits (686), Expect = 7e-72
 Identities = 158/422 (37%), Positives = 240/422 (56%), Gaps = 27/422 (6%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L+F+KG+   I+   E   W+  +   +G+ G + +  +   +++ A+       W+ G
Sbjct: 109 DLSFKKGERFQIINNTEG-DWWEARSIATGKNGYIPSNYVAPADSIQAEE------WYFG 161

Query: 127 KISGQEAVQQLQPP--EDGLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
           K+  ++A + L  P  + G+FLVRES    G Y L +       G +V HY++   D G 
Sbjct: 162 KMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGG 221

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKL--VRPKRKHGTKSAEEELARAGWLLNLQHL 236
             I     F  L  +V+HY++    +C KL  V P  K  T+     LA+  W +  + L
Sbjct: 222 YYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQG----LAKDAWEIPRESL 277

Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
            L  ++G+G FG V  G + G  KVA+K +K   +  +AFL E  +M K++H+ LV L  
Sbjct: 278 RLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYA 337

Query: 295 VILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL 354
           V+  + +YIV E +SKG+L++FL+      +   QL+  +  +A+GM Y+E    +HRDL
Sbjct: 338 VVSEEPIYIVTEFMSKGSLLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDL 397

Query: 355 AARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWS 410
            A NILV E+LV K++DFGLA+     E      ++ P+KWTAPEA  +G+FT KSDVWS
Sbjct: 398 RAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 457

Query: 411 FGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470
           FG+L  E+ + GR PYP M  +EV E VE+GYRM  P+GCP  +H LM+ CW+ +P  RP
Sbjct: 458 FGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERP 517

Query: 471 PF 472
            F
Sbjct: 518 TF 519


>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
          Length = 537

 Score =  264 bits (674), Expect = 2e-70
 Identities = 156/425 (36%), Positives = 242/425 (56%), Gaps = 24/425 (5%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L+F KG+   IL + E   W+  +  T+G+ G + +  +   +++ A+       W+ G
Sbjct: 100 DLSFHKGEKFQILNSSEG-DWWEARSLTTGETGYIPSNYVAPVDSIQAEE------WYFG 152

Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
           K+  ++A +QL    +  G FL+RES    G Y L +       G  V HY++   D G 
Sbjct: 153 KLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGG 212

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEEL-ARAGWLLNLQHLT 237
             I     F  L  +V+HYS+    +C +LV P  K   +  +  +  +  W +  + L 
Sbjct: 213 YYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQ 272

Query: 238 LGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGV 295
           L  ++G G+FG V  G + G  KVA+K +K   ++ ++FL+E  +M K++H+ LV+L  V
Sbjct: 273 LIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAV 332

Query: 296 ILHQGLYIVMEHVSKGNLVNFLRT-RGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDL 354
           +  + +YIV E+++KG+L++FL+   GRAL     L+  +  VA GM Y+E    +HRDL
Sbjct: 333 VSEEPIYIVTEYMNKGSLLDFLKDGEGRAL-KLPNLVDMAAQVAAGMAYIERMNYIHRDL 391

Query: 355 AARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWS 410
            + NILV   L+ K++DFGLA+     E      ++ P+KWTAPEA  +G+FT KSDVWS
Sbjct: 392 RSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWS 451

Query: 411 FGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRP 470
           FG+LL E+ + GR PYP M+ +EV E VE+GYRM  P+ CP  +H LM  CW+ +P  RP
Sbjct: 452 FGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERP 511

Query: 471 PFRKL 475
            F  L
Sbjct: 512 TFEYL 516


>gi|119964721 fer (fps/fes related) tyrosine kinase [Homo sapiens]
          Length = 822

 Score =  264 bits (674), Expect = 2e-70
 Identities = 162/418 (38%), Positives = 239/418 (57%), Gaps = 26/418 (6%)

Query: 76  VTILEACENKSWYR-VKHHTSG----QEGLLAAGALREREALSADPKLSLMPWFHGKISG 130
           VT +E  E  S +  ++H  +G     +  L + AL +  ++S  P L+   W+HG I  
Sbjct: 409 VTSMERKERLSKFESIRHSIAGIIRSPKSALGSSALSDMISISEKP-LAEQDWYHGAIPR 467

Query: 131 QEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRDGHLTIDEAVFFCNL 190
            EA + L+  + G FLVRES   PG+YVL V       H+ + + D      E   F N+
Sbjct: 468 IEAQELLK--KQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRF-EGTGFSNI 524

Query: 191 MDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQIGEGEFGAV 250
             +++H+   K  I        +K G            W+L+ + + LG  +G+G FG V
Sbjct: 525 PQLIDHHYTTKQVIT-------KKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEV 577

Query: 251 LQGEYLGQ-KVAVKNIKCDVTAQA---FLDETAVMTKMQHENLVRLLGVILH-QGLYIVM 305
            +G    +  VAVK  K D+  +    FL E  ++ +  H N+V+L+GV    Q +YI+M
Sbjct: 578 YKGTLKDKTSVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIM 637

Query: 306 EHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILVSEDL 365
           E VS G+ + FLR R +  +   QL++FSL  A GM YLESK  +HRDLAARN LV E+ 
Sbjct: 638 ELVSGGDFLTFLR-RKKDELKLKQLVKFSLDAAAGMLYLESKNCIHRDLAARNCLVGENN 696

Query: 366 VAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWEVFSY 421
           V K+SDFG+++ E  G+ SS    ++P+KWTAPEAL +G+++S+SDVWSFG+LLWE FS 
Sbjct: 697 VLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSL 756

Query: 422 GRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRKLAEKL 479
           G  PYP M+ ++  E VE+GYRM  P+ CP  +  +M  CW+ +P  RP F +L ++L
Sbjct: 757 GVCPYPGMTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKFSELQKEL 814


>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform B [Homo sapiens]
          Length = 491

 Score =  263 bits (673), Expect = 2e-70
 Identities = 152/430 (35%), Positives = 244/430 (56%), Gaps = 26/430 (6%)

Query: 65  PGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWF 124
           P +L+F+KG+ + +LE  E+  W++ K   + +EG + +  + +   L  +       WF
Sbjct: 58  PDDLSFKKGEKMKVLE--EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE------WF 109

Query: 125 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVS-----FGRDVIHYRVLHRD- 176
              I+ ++A +QL  P +  G FL+RES    G + L V       G  + HY++   D 
Sbjct: 110 FKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDN 169

Query: 177 GHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHL 236
           G   I   + F  + DM++HY K    +C +L   ++   +   ++   +  W +  + +
Sbjct: 170 GGYYISPRITFPCISDMIKHYQKQADGLCRRL---EKACISPKPQKPWDKDAWEIPRESI 226

Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
            L  ++G G+FG V  G Y    KVAVK +K   ++ QAFL+E  +M  +QH+ LVRL  
Sbjct: 227 KLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYA 286

Query: 295 VILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRD 353
           V+  +  +YI+ E+++KG+L++FL++     V   +L+ FS  +AEGM Y+E K  +HRD
Sbjct: 287 VVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRD 346

Query: 354 LAARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVW 409
           L A N+LVSE L+ K++DFGLA+     E    + ++ P+KWTAPEA+  G FT KSDVW
Sbjct: 347 LRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVW 406

Query: 410 SFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARR 469
           SFG+LL+E+ +YG+ PYP  +  +V  A+ +GYRM   E CP  ++ +M  CW+ +   R
Sbjct: 407 SFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEER 466

Query: 470 PPFRKLAEKL 479
           P F  L   L
Sbjct: 467 PTFDYLQSVL 476


>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
           isoform A [Homo sapiens]
          Length = 512

 Score =  263 bits (673), Expect = 2e-70
 Identities = 152/430 (35%), Positives = 244/430 (56%), Gaps = 26/430 (6%)

Query: 65  PGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWF 124
           P +L+F+KG+ + +LE  E+  W++ K   + +EG + +  + +   L  +       WF
Sbjct: 79  PDDLSFKKGEKMKVLE--EHGEWWKAKSLLTKKEGFIPSNYVAKLNTLETEE------WF 130

Query: 125 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVS-----FGRDVIHYRVLHRD- 176
              I+ ++A +QL  P +  G FL+RES    G + L V       G  + HY++   D 
Sbjct: 131 FKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVIKHYKIRSLDN 190

Query: 177 GHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHL 236
           G   I   + F  + DM++HY K    +C +L   ++   +   ++   +  W +  + +
Sbjct: 191 GGYYISPRITFPCISDMIKHYQKQADGLCRRL---EKACISPKPQKPWDKDAWEIPRESI 247

Query: 237 TLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLG 294
            L  ++G G+FG V  G Y    KVAVK +K   ++ QAFL+E  +M  +QH+ LVRL  
Sbjct: 248 KLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYA 307

Query: 295 VILHQG-LYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRD 353
           V+  +  +YI+ E+++KG+L++FL++     V   +L+ FS  +AEGM Y+E K  +HRD
Sbjct: 308 VVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRD 367

Query: 354 LAARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVW 409
           L A N+LVSE L+ K++DFGLA+     E    + ++ P+KWTAPEA+  G FT KSDVW
Sbjct: 368 LRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVW 427

Query: 410 SFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARR 469
           SFG+LL+E+ +YG+ PYP  +  +V  A+ +GYRM   E CP  ++ +M  CW+ +   R
Sbjct: 428 SFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKAEER 487

Query: 470 PPFRKLAEKL 479
           P F  L   L
Sbjct: 488 PTFDYLQSVL 497


>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
          Length = 1167

 Score =  261 bits (667), Expect = 1e-69
 Identities = 162/453 (35%), Positives = 243/453 (53%), Gaps = 41/453 (9%)

Query: 68  LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
           L+  KG+ + +L   +N  W  V+  +   +G + +  +    +L          W+HG 
Sbjct: 111 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 162

Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
           +S   A   L    +G FLVRES   PG   + + +   V HYR+    DG + +     
Sbjct: 163 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 222

Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
           F  L ++V H+S     + T L  P  K      +G     ++     W +    +T+  
Sbjct: 223 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 277

Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
           ++G G++G V  G +      VAVK +K D +  + FL E AVM +++H NLV+LLGV  
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
           L    YIV E++  GNL+++LR   R  V    LL  +  ++  MEYLE K  +HRDLAA
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397

Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
           RN LV E+ V KV+DFGL++       ++    + P+KWTAPE+L +  F+ KSDVW+FG
Sbjct: 398 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP  V+ LM +CW+  PA RP F
Sbjct: 458 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517

Query: 473 RK-------------LAEKLARELRSAGAPASV 492
            +             ++E++A EL  A + +SV
Sbjct: 518 AETHQAFETMFHDSSISEEVAEELGRAASSSSV 550


>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
          Length = 1182

 Score =  261 bits (667), Expect = 1e-69
 Identities = 162/453 (35%), Positives = 243/453 (53%), Gaps = 41/453 (9%)

Query: 68  LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
           L+  KG+ + +L   +N  W  V+  +   +G + +  +    +L          W+HG 
Sbjct: 126 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 177

Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
           +S   A   L    +G FLVRES   PG   + + +   V HYR+    DG + +     
Sbjct: 178 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 237

Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
           F  L ++V H+S     + T L  P  K      +G     ++     W +    +T+  
Sbjct: 238 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 292

Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
           ++G G++G V  G +      VAVK +K D +  + FL E AVM +++H NLV+LLGV  
Sbjct: 293 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 352

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
           L    YIV E++  GNL+++LR   R  V    LL  +  ++  MEYLE K  +HRDLAA
Sbjct: 353 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 412

Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
           RN LV E+ V KV+DFGL++       ++    + P+KWTAPE+L +  F+ KSDVW+FG
Sbjct: 413 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 472

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP  V+ LM +CW+  PA RP F
Sbjct: 473 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 532

Query: 473 RK-------------LAEKLARELRSAGAPASV 492
            +             ++E++A EL  A + +SV
Sbjct: 533 AETHQAFETMFHDSSISEEVAEELGRAASSSSV 565


>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
          Length = 1064

 Score =  261 bits (667), Expect = 1e-69
 Identities = 162/453 (35%), Positives = 243/453 (53%), Gaps = 41/453 (9%)

Query: 68  LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
           L+  KG+ + +L   +N  W  V+  +   +G + +  +    +L          W+HG 
Sbjct: 111 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 162

Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
           +S   A   L    +G FLVRES   PG   + + +   V HYR+    DG + +     
Sbjct: 163 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 222

Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
           F  L ++V H+S     + T L  P  K      +G     ++     W +    +T+  
Sbjct: 223 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 277

Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
           ++G G++G V  G +      VAVK +K D +  + FL E AVM +++H NLV+LLGV  
Sbjct: 278 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 337

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
           L    YIV E++  GNL+++LR   R  V    LL  +  ++  MEYLE K  +HRDLAA
Sbjct: 338 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 397

Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
           RN LV E+ V KV+DFGL++       ++    + P+KWTAPE+L +  F+ KSDVW+FG
Sbjct: 398 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 457

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP  V+ LM +CW+  PA RP F
Sbjct: 458 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 517

Query: 473 RK-------------LAEKLARELRSAGAPASV 492
            +             ++E++A EL  A + +SV
Sbjct: 518 AETHQAFETMFHDSSISEEVAEELGRAASSSSV 550


>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
          Length = 1146

 Score =  261 bits (667), Expect = 1e-69
 Identities = 162/453 (35%), Positives = 243/453 (53%), Gaps = 41/453 (9%)

Query: 68  LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
           L+  KG+ + +L   +N  W  V+  +   +G + +  +    +L          W+HG 
Sbjct: 90  LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 141

Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
           +S   A   L    +G FLVRES   PG   + + +   V HYR+    DG + +     
Sbjct: 142 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 201

Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
           F  L ++V H+S     + T L  P  K      +G     ++     W +    +T+  
Sbjct: 202 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 256

Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
           ++G G++G V  G +      VAVK +K D +  + FL E AVM +++H NLV+LLGV  
Sbjct: 257 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 316

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
           L    YIV E++  GNL+++LR   R  V    LL  +  ++  MEYLE K  +HRDLAA
Sbjct: 317 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 376

Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
           RN LV E+ V KV+DFGL++       ++    + P+KWTAPE+L +  F+ KSDVW+FG
Sbjct: 377 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 436

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP  V+ LM +CW+  PA RP F
Sbjct: 437 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 496

Query: 473 RK-------------LAEKLARELRSAGAPASV 492
            +             ++E++A EL  A + +SV
Sbjct: 497 AETHQAFETMFHDSSISEEVAEELGRAASSSSV 529


>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
          Length = 505

 Score =  261 bits (666), Expect = 1e-69
 Identities = 159/434 (36%), Positives = 244/434 (56%), Gaps = 24/434 (5%)

Query: 59  EHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKL 118
           ++T     +L   KG+ + +L+   +  W+  +   +G+EG + +  +   E+L  +   
Sbjct: 68  DYTAMNDRDLQMLKGEKLQVLKGTGD--WWLARSLVTGREGYVPSNFVARVESLEMER-- 123

Query: 119 SLMPWFHGKISGQEAVQQLQPP--EDGLFLVRESARHPGDYVLCV----SFGRDVIHYRV 172
               WF      +EA +QL  P  + G FL+RES  + G + L V    + G  + HY++
Sbjct: 124 ----WFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIKHYKI 179

Query: 173 LHRD-GHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLL 231
              D G   I   + F +L  +V+HYSK    +C +L  P  +    + +   A+  W +
Sbjct: 180 RCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVR---PAPQNPWAQDEWEI 236

Query: 232 NLQHLTLGAQIGEGEFGAVLQGEYLGQ-KVAVKNIK-CDVTAQAFLDETAVMTKMQHENL 289
             Q L L  ++G G+FG V  G Y    KVA+K +K   ++ +AFL E  VM  +QHE L
Sbjct: 237 PRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQHERL 296

Query: 290 VRLLGVILHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKL 349
           VRL  V+  + +YIV E++++G L++FL+T   + ++  +L+  S  +AEGM Y+E    
Sbjct: 297 VRLYAVVTKEPIYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAYIERMNS 356

Query: 350 VHRDLAARNILVSEDLVAKVSDFGLAK---AERKGLDSSRLPVKWTAPEALKHGKFTSKS 406
           +HRDL A NILVSE L  K++DFGLA+   +E    + ++ P+KWTAPEA+  G FT K+
Sbjct: 357 IHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFGVFTIKA 416

Query: 407 DVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVH-VLMSSCWEAE 465
           DVWSFGVLL EV +YGR PYP MS  EV   +E+GYRM  P+ CP  ++  +++ CW + 
Sbjct: 417 DVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIAECWRSR 476

Query: 466 PARRPPFRKLAEKL 479
           P  RP F  L   L
Sbjct: 477 PEERPTFEFLQSVL 490


>gi|5174647 PTK6 protein tyrosine kinase 6 [Homo sapiens]
          Length = 451

 Score =  261 bits (666), Expect = 1e-69
 Identities = 164/426 (38%), Positives = 240/426 (56%), Gaps = 21/426 (4%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQ--EGLLAAGALREREALSADPKLSLMPWF 124
           EL+FR GDV  +    E   W  +     G   +G +    L ERE + ++P      WF
Sbjct: 26  ELSFRAGDVFHVARKEEQWWWATLLDEAGGAVAQGYVPHNYLAERETVESEP------WF 79

Query: 125 HGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSFGRDVIHYRVLHR-DGHLTI 181
            G IS  EAV++LQ   +  G FL+R S +   DYVL V   + V HY++  R  G L +
Sbjct: 80  FGCISRSEAVRRLQAEGNATGAFLIRVSEKPSADYVLSVRDTQAVRHYKIWRRAGGRLHL 139

Query: 182 DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ 241
           +EAV F +L ++V ++     +   +L  P RKH  +          W    +  TL  +
Sbjct: 140 NEAVSFLSLPELVNYHRAQSLSHGLRLAAPCRKHEPEPLPHW---DDWERPREEFTLCRK 196

Query: 242 IGEGEFGAVLQGEYLGQ-KVAVKNIKCD--VTAQAFLDETAVMTKMQHENLVRLLGVI-L 297
           +G G FG V +G +  + +VA+K I  D  +  Q    E   M K++H++++ L  V+ +
Sbjct: 197 LGSGYFGEVFEGLWKDRVQVAIKVISRDNLLHQQMLQSEIQAMKKLRHKHILALYAVVSV 256

Query: 298 HQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAAR 357
              +YI+ E ++KG+L+  LR     ++  ++LL  +  VAEGM YLES+  +HRDLAAR
Sbjct: 257 GDPVYIITELMAKGSLLELLRDSDEKVLPVSELLDIAWQVAEGMCYLESQNYIHRDLAAR 316

Query: 358 NILVSEDLVAKVSDFGLAKAERKGLDSSR---LPVKWTAPEALKHGKFTSKSDVWSFGVL 414
           NILV E+ + KV DFGLA+  ++ +  S    +P KWTAPEAL  G +++KSDVWSFG+L
Sbjct: 317 NILVGENTLCKVGDFGLARLIKEDVYLSHDHNIPYKWTAPEALSRGHYSTKSDVWSFGIL 376

Query: 415 LWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK 474
           L E+FS G+ PYP MS  E    V+ GYRM  P  CP  VH LM +CW  +P +RP F+ 
Sbjct: 377 LHEMFSRGQVPYPGMSNHEAFLRVDAGYRMPCPLECPPSVHKLMLTCWCRDPEQRPCFKA 436

Query: 475 LAEKLA 480
           L E+L+
Sbjct: 437 LRERLS 442


>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
           [Homo sapiens]
          Length = 1130

 Score =  259 bits (662), Expect = 4e-69
 Identities = 158/449 (35%), Positives = 239/449 (53%), Gaps = 31/449 (6%)

Query: 68  LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
           L+  KG+ + +L    N  W   +  T   +G + +  +    +L          W+HG 
Sbjct: 80  LSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSLEKHS------WYHGP 131

Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
           +S   A   L    +G FLVRES   PG   + + +   V HYR+    DG L +     
Sbjct: 132 VSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESR 191

Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAG-WLLNLQHLTLGAQIGEG 245
           F  L ++V H+S     + T L  P  K    +          W +    +T+  ++G G
Sbjct: 192 FNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGG 251

Query: 246 EFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVILHQG-L 301
           ++G V +G +      VAVK +K D +  + FL E AVM +++H NLV+LLGV   +   
Sbjct: 252 QYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF 311

Query: 302 YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV 361
           YI+ E ++ GNL+++LR   R  VN   LL  +  ++  MEYLE K  +HRDLAARN LV
Sbjct: 312 YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 371

Query: 362 SEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWE 417
            E+ + KV+DFGL++       ++    + P+KWTAPE+L + KF+ KSDVW+FGVLLWE
Sbjct: 372 GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWE 431

Query: 418 VFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK--- 474
           + +YG +PYP + L +V E +EK YRME PEGCP  V+ LM +CW+  P+ RP F +   
Sbjct: 432 IATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 491

Query: 475 ----------LAEKLARELRSAGAPASVS 493
                     +++++ +EL   G   +VS
Sbjct: 492 AFETMFQESSISDEVEKELGKQGVRGAVS 520


>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
           [Homo sapiens]
          Length = 1149

 Score =  259 bits (662), Expect = 4e-69
 Identities = 158/449 (35%), Positives = 239/449 (53%), Gaps = 31/449 (6%)

Query: 68  LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
           L+  KG+ + +L    N  W   +  T   +G + +  +    +L          W+HG 
Sbjct: 99  LSITKGEKLRVLGYNHNGEWCEAQ--TKNGQGWVPSNYITPVNSLEKHS------WYHGP 150

Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
           +S   A   L    +G FLVRES   PG   + + +   V HYR+    DG L +     
Sbjct: 151 VSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESR 210

Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAG-WLLNLQHLTLGAQIGEG 245
           F  L ++V H+S     + T L  P  K    +          W +    +T+  ++G G
Sbjct: 211 FNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGG 270

Query: 246 EFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVILHQG-L 301
           ++G V +G +      VAVK +K D +  + FL E AVM +++H NLV+LLGV   +   
Sbjct: 271 QYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPF 330

Query: 302 YIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAARNILV 361
           YI+ E ++ GNL+++LR   R  VN   LL  +  ++  MEYLE K  +HRDLAARN LV
Sbjct: 331 YIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLV 390

Query: 362 SEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFGVLLWE 417
            E+ + KV+DFGL++       ++    + P+KWTAPE+L + KF+ KSDVW+FGVLLWE
Sbjct: 391 GENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWE 450

Query: 418 VFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFRK--- 474
           + +YG +PYP + L +V E +EK YRME PEGCP  V+ LM +CW+  P+ RP F +   
Sbjct: 451 IATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQ 510

Query: 475 ----------LAEKLARELRSAGAPASVS 493
                     +++++ +EL   G   +VS
Sbjct: 511 AFETMFQESSISDEVEKELGKQGVRGAVS 539


>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  259 bits (661), Expect = 5e-69
 Identities = 160/434 (36%), Positives = 235/434 (54%), Gaps = 23/434 (5%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L F KG+   IL   E   W+  +  +SG+ G + +  +   +++ A+       W+ G
Sbjct: 95  DLTFTKGEKFHILNNTEG-DWWEARSLSSGKTGCIPSNYVAPVDSIQAEE------WYFG 147

Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-GH 178
           KI  ++A +QL  P +  G FL+RES    G Y L +     + G  V HY++   D G 
Sbjct: 148 KIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGG 207

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
             I   V F ++ ++V+HY +    +C  L+ P      K     LA+  W ++   +TL
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTI--MKPQTLGLAKDAWEISRSSITL 265

Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI 296
             ++G G FG V  G + G  KVAVK +K   ++ +AFL+E  VM  ++H+ LV+L  V+
Sbjct: 266 ERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV 325

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
             + +YIV E +  G+L++FL+      +   QL+  +  VAEGM Y+E    +HRDL A
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385

Query: 357 RNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFG 412
            NILV E L  K++DFGLA+     E      S+ P+KWTAPEA   G+FT KSDVWSFG
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFG 445

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           +LL E+ + GR PYP M+ +EV E VE+GY M  P GCP  ++  M   W  +P  RP F
Sbjct: 446 ILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTF 505

Query: 473 RKLAEKLARELRSA 486
             L   L     SA
Sbjct: 506 EYLQSFLEDYFTSA 519


>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  259 bits (661), Expect = 5e-69
 Identities = 160/434 (36%), Positives = 235/434 (54%), Gaps = 23/434 (5%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L F KG+   IL   E   W+  +  +SG+ G + +  +   +++ A+       W+ G
Sbjct: 95  DLTFTKGEKFHILNNTEG-DWWEARSLSSGKTGCIPSNYVAPVDSIQAEE------WYFG 147

Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-GH 178
           KI  ++A +QL  P +  G FL+RES    G Y L +     + G  V HY++   D G 
Sbjct: 148 KIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGG 207

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
             I   V F ++ ++V+HY +    +C  L+ P      K     LA+  W ++   +TL
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTI--MKPQTLGLAKDAWEISRSSITL 265

Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI 296
             ++G G FG V  G + G  KVAVK +K   ++ +AFL+E  VM  ++H+ LV+L  V+
Sbjct: 266 ERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV 325

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
             + +YIV E +  G+L++FL+      +   QL+  +  VAEGM Y+E    +HRDL A
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385

Query: 357 RNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFG 412
            NILV E L  K++DFGLA+     E      S+ P+KWTAPEA   G+FT KSDVWSFG
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFG 445

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           +LL E+ + GR PYP M+ +EV E VE+GY M  P GCP  ++  M   W  +P  RP F
Sbjct: 446 ILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTF 505

Query: 473 RKLAEKLARELRSA 486
             L   L     SA
Sbjct: 506 EYLQSFLEDYFTSA 519


>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
           sapiens]
          Length = 529

 Score =  259 bits (661), Expect = 5e-69
 Identities = 160/434 (36%), Positives = 235/434 (54%), Gaps = 23/434 (5%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L F KG+   IL   E   W+  +  +SG+ G + +  +   +++ A+       W+ G
Sbjct: 95  DLTFTKGEKFHILNNTEG-DWWEARSLSSGKTGCIPSNYVAPVDSIQAEE------WYFG 147

Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCV-----SFGRDVIHYRVLHRD-GH 178
           KI  ++A +QL  P +  G FL+RES    G Y L +     + G  V HY++   D G 
Sbjct: 148 KIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVKHYKIRKLDMGG 207

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
             I   V F ++ ++V+HY +    +C  L+ P      K     LA+  W ++   +TL
Sbjct: 208 YYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTI--MKPQTLGLAKDAWEISRSSITL 265

Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI 296
             ++G G FG V  G + G  KVAVK +K   ++ +AFL+E  VM  ++H+ LV+L  V+
Sbjct: 266 ERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLLRHDKLVQLYAVV 325

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
             + +YIV E +  G+L++FL+      +   QL+  +  VAEGM Y+E    +HRDL A
Sbjct: 326 SEEPIYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMAYMERMNYIHRDLRA 385

Query: 357 RNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSFG 412
            NILV E L  K++DFGLA+     E      S+ P+KWTAPEA   G+FT KSDVWSFG
Sbjct: 386 ANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAALFGRFTIKSDVWSFG 445

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           +LL E+ + GR PYP M+ +EV E VE+GY M  P GCP  ++  M   W  +P  RP F
Sbjct: 446 ILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAMEQTWRLDPEERPTF 505

Query: 473 RKLAEKLARELRSA 486
             L   L     SA
Sbjct: 506 EYLQSFLEDYFTSA 519


>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
          Length = 542

 Score =  258 bits (658), Expect = 1e-68
 Identities = 155/420 (36%), Positives = 229/420 (54%), Gaps = 28/420 (6%)

Query: 68  LAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHGK 127
           L+  KG+ + +L   +N  W  V+  +   +G + +  +    +L          W+HG 
Sbjct: 105 LSITKGEKLRVLGYNQNGEWSEVR--SKNGQGWVPSNYITPVNSLEKHS------WYHGP 156

Query: 128 ISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTIDEAVF 186
           +S   A   L    +G FLVRES   PG   + + +   V HYR+    DG + +     
Sbjct: 157 VSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESR 216

Query: 187 FCNLMDMVEHYSKDKGAICTKLVRPKRK------HGTKSAEEELARAGWLLNLQHLTLGA 240
           F  L ++V H+S     + T L  P  K      +G     ++     W +    +T+  
Sbjct: 217 FSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-----WEMERTDITMKH 271

Query: 241 QIGEGEFGAVLQGEY--LGQKVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI- 296
           ++G G++G V  G +      VAVK +K D +  + FL E AVM +++H NLV+LLGV  
Sbjct: 272 KLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCT 331

Query: 297 LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAA 356
           L    YIV E++  GNL+++LR   R  V    LL  +  ++  MEYLE K  +HRDLAA
Sbjct: 332 LEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDLAA 391

Query: 357 RNILVSEDLVAKVSDFGLAKAERKGLDSS----RLPVKWTAPEALKHGKFTSKSDVWSFG 412
           RN LV E+ V KV+DFGL++       ++    + P+KWTAPE+L +  F+ KSDVW+FG
Sbjct: 392 RNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFG 451

Query: 413 VLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPF 472
           VLLWE+ +YG +PYP + L +V + +EKGYRME PEGCP  V+ LM +CW+  PA RP F
Sbjct: 452 VLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSF 511


>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
          Length = 534

 Score =  255 bits (652), Expect = 6e-68
 Identities = 154/424 (36%), Positives = 239/424 (56%), Gaps = 25/424 (5%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPKLSLMPWFHG 126
           +L+F KG+   IL + E   W+  +  T+G+ G + +  +   +++ A+       W+ G
Sbjct: 100 DLSFHKGEKFQILNSSEG-DWWEARSLTTGETGYIPSNYVAPVDSIQAEE------WYFG 152

Query: 127 KISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSF-----GRDVIHYRVLHRD-GH 178
           K+  ++A +QL    +  G FL+RES    G Y L +       G  V HY++   D G 
Sbjct: 153 KLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGG 212

Query: 179 LTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTL 238
             I     F  L  +V+HYS+    +C  L         +++   LA+  W +  + L L
Sbjct: 213 YYITTRAQFETLQQLVQHYSEKADGLCFNLTVIASSCTPQTSG--LAKDAWEVARRSLCL 270

Query: 239 GAQIGEGEFGAVLQGEYLGQ-KVAVKNIKCD-VTAQAFLDETAVMTKMQHENLVRLLGVI 296
             ++G+G F  V  G + G  KVA+K +K   ++ ++FL+E  +M K++H+ LV+L  V+
Sbjct: 271 EKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVV 330

Query: 297 LHQGLYIVMEHVSKGNLVNFLRT-RGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355
             + +YIV E+++KG+L++FL+   GRAL     L+  +  VA GM Y+E    +HRDL 
Sbjct: 331 SEEPIYIVTEYMNKGSLLDFLKDGEGRAL-KLPNLVDMAAQVAAGMAYIERMNYIHRDLR 389

Query: 356 ARNILVSEDLVAKVSDFGLAKA----ERKGLDSSRLPVKWTAPEALKHGKFTSKSDVWSF 411
           + NILV   L+ K++DFGLA+     E      ++ P+KWTAPEA  +G+FT KSDVWSF
Sbjct: 390 SANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSF 449

Query: 412 GVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPP 471
           G+LL E+ + GR PYP M+ +EV E VE+GYRM  P+ CP  +H LM  CW+ +P  RP 
Sbjct: 450 GILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPT 509

Query: 472 FRKL 475
           F  L
Sbjct: 510 FEYL 513


>gi|18250298 src-related kinase lacking C-terminal regulatory
           tyrosine and N-terminal myristylation sites [Homo
           sapiens]
          Length = 488

 Score =  255 bits (651), Expect = 8e-68
 Identities = 171/426 (40%), Positives = 232/426 (54%), Gaps = 25/426 (5%)

Query: 66  GELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALREREALSADPK-LSLMPWF 124
           GEL+ R+GD +  LE       Y      SGQ    +AG +       A P+ LS  PW+
Sbjct: 68  GELSVRRGDRLCALE---EGGGYIFARRLSGQP---SAGLVPITHVAKASPETLSDQPWY 121

Query: 125 HGKISGQEAVQQLQPP--EDGLFLVRESARHPGDYVLCVSFGRDVIHYRV-LHRDGHLTI 181
              +S  +A Q L  P  E G FL+R S    G Y L V     V HYRV +  DG L +
Sbjct: 122 FSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYL 181

Query: 182 DEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARAGWLLNLQHLTLGAQ 241
            +   F  L +++ +Y  +   I   L++P      K+  +++    W        LG +
Sbjct: 182 QKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQ--KAPRQDV----WERPHSEFALGRK 235

Query: 242 IGEGEFGAVLQGEYLGQ-KVAVKNIK-CDVTAQAFLDETAVMTKMQHENLVRLLGVILH- 298
           +GEG FG V +G +LG   VA+K IK  ++       E   +  ++HE L+RL  V    
Sbjct: 236 LGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGG 295

Query: 299 QGLYIVMEHVSKGNLVNFLRT-RGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLAAR 357
           + +YIV E + KGNL  FL T  GRAL     LL F+  VAEGM YLE +++VHRDLAAR
Sbjct: 296 EPVYIVTELMRKGNLQAFLGTPEGRAL-RLPPLLGFACQVAEGMSYLEEQRVVHRDLAAR 354

Query: 358 NILVSEDLVAKVSDFGLAKAERKGL----DSSRLPVKWTAPEALKHGKFTSKSDVWSFGV 413
           N+LV + L  KV+DFGLA+  +  +     SS++PVKWTAPEA  +  F+ KSDVWSFGV
Sbjct: 355 NVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGV 414

Query: 414 LLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPARRPPFR 473
           LL EVF+YG+ PY  M+  E  + + +GYR+  P  CP  V+VLM  CW + P  RP F 
Sbjct: 415 LLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFA 474

Query: 474 KLAEKL 479
            L EKL
Sbjct: 475 TLREKL 480


>gi|4503787 fyn-related kinase [Homo sapiens]
          Length = 505

 Score =  245 bits (626), Expect = 6e-65
 Identities = 152/431 (35%), Positives = 233/431 (54%), Gaps = 21/431 (4%)

Query: 67  ELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR---EREALSADPKLSLMPW 123
           +L+FR GD + +L+   ++ W+  +H    ++G  ++  L+       ++ D  L   PW
Sbjct: 60  DLSFRAGDKLQVLDTL-HEGWWFARHLEKRRDG--SSQQLQGYIPSNYVAEDRSLQAEPW 116

Query: 124 FHGKISGQEAVQQLQPPED--GLFLVRESARHPGDYVLCVSFGRDVIHYRVLHRD-GHLT 180
           F G I   +A +QL   E+  G FL+RES    G++ L V  G  V HYR+   D G   
Sbjct: 117 FFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFF 176

Query: 181 IDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA--GWLLNLQHLTL 238
           +     F  L + V HY+K    +C KL +P  K    +  +   +    W ++   + L
Sbjct: 177 LTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQL 236

Query: 239 GAQIGEGEFGAVLQGEYLGQK-VAVKNIKC-DVTAQAFLDETAVMTKMQHENLVRLLGVI 296
             ++G G+FG V +G +     VAVK +K   +    FL E  +M  ++H  L++L  V 
Sbjct: 237 LKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVC 296

Query: 297 -LHQGLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLESKKLVHRDLA 355
            L   +YI+ E +  G+L  +L+    + ++  Q +  +  VA GM YLES+  +HRDLA
Sbjct: 297 TLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLA 356

Query: 356 ARNILVSEDLVAKVSDFGLA---KAERKGLDSSR----LPVKWTAPEALKHGKFTSKSDV 408
           ARN+LV E  + KV+DFGLA   K + + +  SR    LPVKWTAPEA++  KF+ KSDV
Sbjct: 357 ARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDV 416

Query: 409 WSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAEPAR 468
           WSFG+LL+E+ +YG+ PY  M+  +V + + + YR+  P  CP   + +M  CW AEP  
Sbjct: 417 WSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKE 476

Query: 469 RPPFRKLAEKL 479
           RP F  L  KL
Sbjct: 477 RPTFETLRWKL 487


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,310,293
Number of Sequences: 37866
Number of extensions: 1035329
Number of successful extensions: 4868
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 650
Number of HSP's successfully gapped in prelim test: 306
Number of HSP's that attempted gapping in prelim test: 2763
Number of HSP's gapped (non-prelim): 1153
length of query: 508
length of database: 18,247,518
effective HSP length: 107
effective length of query: 401
effective length of database: 14,195,856
effective search space: 5692538256
effective search space used: 5692538256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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