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Search of human proteins with 21361633
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
(602 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 1170 0.0
gi|238908508 leucine-rich repeat and death domain-containing pro... 183 5e-46
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 180 3e-45
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 152 9e-37
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 149 7e-36
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 149 9e-36
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 149 9e-36
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 139 1e-32
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 139 1e-32
gi|45827729 scribble isoform b [Homo sapiens] 138 2e-32
gi|45827731 scribble isoform a [Homo sapiens] 138 2e-32
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 131 2e-30
gi|37221175 PH domain and leucine rich repeat protein phosphatas... 128 1e-29
gi|4503743 flightless I homolog [Homo sapiens] 117 4e-26
gi|225579152 insulin-like growth factor binding protein, acid la... 112 1e-24
gi|4826772 insulin-like growth factor binding protein, acid labi... 112 1e-24
gi|193788651 leucine rich repeat containing 69 [Homo sapiens] 112 1e-24
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 109 6e-24
gi|61742786 leucine rich repeat and death domain containing prot... 108 1e-23
gi|61742784 leucine rich repeat and death domain containing prot... 108 1e-23
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 108 1e-23
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 108 2e-23
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 106 5e-23
gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens] 105 1e-22
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 103 6e-22
gi|62241040 leucine rich repeat containing 8 family, member A [H... 102 8e-22
gi|187829877 leucine rich repeat containing 8 family, member A [... 102 8e-22
gi|187829871 leucine rich repeat containing 8 family, member A [... 102 8e-22
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 102 1e-21
gi|197333692 leucine rich repeat containing 8 family, member B [... 100 3e-21
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 1170 bits (3026), Expect = 0.0
Identities = 602/602 (100%), Positives = 602/602 (100%)
Query: 1 MSRLKRIAGQDLRAGFKAGGRDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINV 60
MSRLKRIAGQDLRAGFKAGGRDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINV
Sbjct: 1 MSRLKRIAGQDLRAGFKAGGRDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINV 60
Query: 61 DIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSL 120
DIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSL
Sbjct: 61 DIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSL 120
Query: 121 PSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLD 180
PSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLD
Sbjct: 121 PSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLD 180
Query: 181 LSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELA 240
LSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELA
Sbjct: 181 LSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELA 240
Query: 241 GMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNK 300
GMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNK
Sbjct: 241 GMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNK 300
Query: 301 LKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQE 360
LKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQE
Sbjct: 301 LKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQE 360
Query: 361 VLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFD 420
VLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFD
Sbjct: 361 VLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFD 420
Query: 421 AVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLR 480
AVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLR
Sbjct: 421 AVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLR 480
Query: 481 NNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKM 540
NNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKM
Sbjct: 481 NNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKM 540
Query: 541 MENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRI 600
MENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRI
Sbjct: 541 MENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRI 600
Query: 601 PT 602
PT
Sbjct: 601 PT 602
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 183 bits (464), Expect = 5e-46
Identities = 150/503 (29%), Positives = 245/503 (48%), Gaps = 46/503 (9%)
Query: 104 LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL 163
L L +L + +N L+SLPS I+ L NL+ LNVSHN + +P+EI+ L N++ L+ +N +
Sbjct: 187 LLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYI 246
Query: 164 TCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLK 223
E L NLE L L N L +P + SL +L LNL N+L + P + + +L
Sbjct: 247 ENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLI 306
Query: 224 HLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIEMLEA 282
LD NL+ ++P E+ +++LE L + NKL FL E +KEL + +N++E++ +
Sbjct: 307 SLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVI-S 365
Query: 283 EHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP---YSLGNL----- 334
+++ + +L L N LK++P++I LE L LS+N ++ LP + L NL
Sbjct: 366 HKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHV 425
Query: 335 -------------HLK---FLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSE 378
HL L GN + + EI K Q+++K S K
Sbjct: 426 NRNNMVKITDCISHLNNICSLEFSGNIITDVPIEI--KNCQKIIKIELSYNKIMYFPLGL 483
Query: 379 SATETAMTLP------SESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINF 432
A ++ L SE V+I L L+ S+ + + + + + ++
Sbjct: 484 CALDSLYYLSVNGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLIN---LKYLDL 540
Query: 433 SKNQLCEIP---KRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPE 489
KNQ+ +IP M+ L ++ L NK ELC L+ L LDL N L +
Sbjct: 541 GKNQIKKIPASISNMISLHVLI----LCCNKFETFPRELCTLENLQVLDLSENQLQKISS 596
Query: 490 EMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVD--PQKMKMMENLTTL 547
++ +L +Q +N S N+F P L ++ +LE + IS + + P ++ M L L
Sbjct: 597 DICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKEL 656
Query: 548 DLQNNDLLQIPPELGNCVNLRTL 570
D+ NN + +IP +G NL +L
Sbjct: 657 DISNNAIREIPRNIGELRNLVSL 679
Score = 166 bits (420), Expect = 6e-41
Identities = 153/631 (24%), Positives = 282/631 (44%), Gaps = 97/631 (15%)
Query: 41 LNLSGRNLSEVPQCVWRINVD--IPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLT 98
+NL + L E P+ + +I + + NQ +F + + L L + N L SL
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSG-DLLGLEILSLQENGLSSLP 204
Query: 99 DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKL-----------------------NV 135
+++LL L +L++ N ++ +P I +L N+++L ++
Sbjct: 205 SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSL 264
Query: 136 SHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSS 195
NKL+ +P+ + +L+ L+ L L++N+LT + L L LDL+ N ++++P
Sbjct: 265 GKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRE 324
Query: 196 LSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKL 255
L +L L + N+L L EI ++ ++K L N LE I ++ L +L L +N L
Sbjct: 325 LKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLL 384
Query: 256 RFLPEFPSC------------------------SLLKELHVGENQIEMLEAEHLKHLNSI 291
+ +PE SC + L++LHV N + + + + HLN+I
Sbjct: 385 KNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKI-TDCISHLNNI 443
Query: 292 LVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIR 350
L+ N + VP EI + + +++LS N I P L L L +L++ GN + I
Sbjct: 444 CSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIP 503
Query: 351 REIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQ 410
+I + L +L +E + + SE + ++I LK LD Q
Sbjct: 504 VDI---SFSKQLLHL-------------ELSENKLLIFSE---HFCSLINLKYLDLGKNQ 544
Query: 411 ATLIPDEVFDAVKSNI--------------------VTSINFSKNQLCEIPKRMVELKEM 450
IP + + + ++ + ++ S+NQL +I + LK
Sbjct: 545 IKKIPASISNMISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKG- 603
Query: 451 VSDVDLSFNKLSFISLELCVLQKLTFLD---LRNNFLNSLPEEMESLVRLQTINLSFNRF 507
+ ++ S N+ +ELC LQ L L+ ++ L LP E+ ++ +L+ +++S N
Sbjct: 604 IQKLNFSSNQFIHFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAI 663
Query: 508 KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNL 567
+ +P + + L ++ NNQ+ + P + + +L L+L N+L +P + N +L
Sbjct: 664 REIPRNIGELRNLVSLHAYNNQISYLPPSLLS-LNDLQQLNLSGNNLTALPSAIYNIFSL 722
Query: 568 RTLLLDGNPFRVPRAAILM-KGTAAILEYLR 597
+ + D NP P I K I YL+
Sbjct: 723 KEINFDDNPLLRPPVEICKGKQLYTIARYLQ 753
Score = 32.3 bits (72), Expect = 1.3
Identities = 20/77 (25%), Positives = 35/77 (45%)
Query: 499 TINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIP 558
T+NL + P+ + +I ++ + + NQ+ + + L L LQ N L +P
Sbjct: 145 TVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLP 204
Query: 559 PELGNCVNLRTLLLDGN 575
E+ NLR L + N
Sbjct: 205 SEIQLLHNLRILNVSHN 221
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 180 bits (457), Expect = 3e-45
Identities = 144/491 (29%), Positives = 233/491 (47%), Gaps = 66/491 (13%)
Query: 86 KLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145
+L +S + L ++ L LT L ++ N+L SLP+ + L NL L +S N L LP+
Sbjct: 104 RLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
Query: 146 EITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLS 205
+ NL+ L+ L L+HN+L I +L +L L L N +TTV +LS L L++
Sbjct: 164 SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
Query: 206 SNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCS 265
N++K LPAEI + L LD N LE +P E+ + L L+ N+L LP
Sbjct: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP------ 277
Query: 266 LLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDIS 325
+ + +L+S+ L LR N+L ++P + +LE L+L NN+IS
Sbjct: 278 -----------------DTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIS 320
Query: 326 SLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAM 385
+LP SL + +K +L T+ R GPSQ
Sbjct: 321 TLPESLLSSLVKLNSL------TLARNCF------------QLYPVGGPSQ--------- 353
Query: 386 TLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMV 445
T+ L+ + IP +F K +++ +N NQL +P
Sbjct: 354 ------------FSTIYSLNMEHNRINKIPFGIFSRAK--VLSKLNMKDNQLTSLPLDFG 399
Query: 446 ELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFN 505
MV +++L+ N+L+ I ++ L L L L NN L LP + +L +L+ ++L N
Sbjct: 400 TWTSMV-ELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEEN 458
Query: 506 RFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCV 565
+ + LP + + L+ ++++NNQ+ ++ P+ + + NLT L L N L +P E+G
Sbjct: 459 KLESLPNEIAYLKDLQKLVLTNNQLTTL-PRGIGHLTNLTHLGLGENLLTHLPEEIGTLE 517
Query: 566 NLRTLLLDGNP 576
NL L L+ NP
Sbjct: 518 NLEELYLNDNP 528
Score = 158 bits (399), Expect = 2e-38
Identities = 128/469 (27%), Positives = 227/469 (48%), Gaps = 30/469 (6%)
Query: 110 LDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEG 169
LD+ + LPS+I+EL L +L + NKL+ LP E+ L NL L L N LT + +
Sbjct: 105 LDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDS 164
Query: 170 FEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNS 229
+ L L LDL +N L +P+ L SL L L N + ++ +I + +L L
Sbjct: 165 LDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRE 224
Query: 230 NLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIEMLEAEHLKHL 288
N ++ +P E+ + +L L + N+L LP E +C+ + L + N++ L + + +L
Sbjct: 225 NKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLP-DTIGNL 283
Query: 289 NSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALE------ 342
+S+ L LR N+L ++P + +LE L+L NN+IS+LP SL + +K +L
Sbjct: 284 SSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCF 343
Query: 343 -----GNPLRTIRREIISKGTQEVLK-----YLRSKIKDDGPSQSESATETAMTLPSESR 392
G P + ++ + K + R+K+ + T +LP
Sbjct: 344 QLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLT----SLP---- 395
Query: 393 VNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVS 452
++ ++ L+ + Q T IP++V V ++ S N L ++P + L+++
Sbjct: 396 LDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLI---LSNNLLKKLPHGLGNLRKL-R 451
Query: 453 DVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPE 512
++DL NKL + E+ L+ L L L NN L +LP + L L + L N LPE
Sbjct: 452 ELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPE 511
Query: 513 VLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPEL 561
+ + LE + +++N P ++ + L+ + ++N L +PP++
Sbjct: 512 EIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQI 560
Score = 102 bits (255), Expect = 8e-22
Identities = 100/385 (25%), Positives = 173/385 (44%), Gaps = 74/385 (19%)
Query: 218 RMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSL-LKELHVGENQ 276
R + LD + + +P + + L LYL NKL+ LP C + L L + EN
Sbjct: 98 REENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENS 157
Query: 277 IEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHL 336
+ L + L +L + +LDLR NKL+ +P + RLD SL L+L
Sbjct: 158 LTSL-PDSLDNLKKLRMLDLRHNKLREIPSVVY------RLD-----------SLTTLYL 199
Query: 337 KFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIH 396
+F N + T+ ++I + +L +KIK LP+E I
Sbjct: 200 RF-----NRITTVEKDIKNLSKLSMLSIRENKIKQ---------------LPAE----IG 235
Query: 397 AIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDL 456
+ L LD + Q +P E+ + + +T+++ N+L ++P + L + S + L
Sbjct: 236 ELCNLITLDVAHNQLEHLPKEIGNCTQ---ITNLDLQHNELLDLPDTIGNLSSL-SRLGL 291
Query: 457 SFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEE-MESLVRLQTINLSFNRFKMLP---- 511
+N+LS I L L L+L NN +++LPE + SLV+L ++ L+ N F++ P
Sbjct: 292 RYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGP 351
Query: 512 -----------------EVLYRIFTLETIL----ISNNQVGSVDPQKMKMMENLTTLDLQ 550
++ + IF+ +L + +NQ+ S+ P ++ L+L
Sbjct: 352 SQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSL-PLDFGTWTSMVELNLA 410
Query: 551 NNDLLQIPPELGNCVNLRTLLLDGN 575
N L +IP ++ V+L L+L N
Sbjct: 411 TNQLTKIPEDVSGLVSLEVLILSNN 435
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/110 (29%), Positives = 55/110 (50%), Gaps = 1/110 (0%)
Query: 466 LELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILI 525
L C + LDL ++ LP ++ L +L + L N+ + LP + + L T+ +
Sbjct: 94 LNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLAL 153
Query: 526 SNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
S N + S+ P + ++ L LDL++N L +IP + +L TL L N
Sbjct: 154 SENSLTSL-PDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN 202
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 152 bits (384), Expect = 9e-37
Identities = 138/530 (26%), Positives = 236/530 (44%), Gaps = 52/530 (9%)
Query: 86 KLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145
K + + K+ D + +D + LT++P I L+++++ +N+++ +P+
Sbjct: 6 KSVEHSPKIHQRNDPQHVNDRTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQ 65
Query: 146 EITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHL---TTVPASFSSLSSLVRL 202
EI L+N++ LYL N L + LS+LE LDLS N + + V SF L +L L
Sbjct: 66 EIQRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPIFSSSLVVVSF--LHALREL 123
Query: 203 NLSSNELKSLPAEINRMKRLKHLD---CNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
L +LK +P I K L HL+ N L+ +P E+ L +YL+RN+ P
Sbjct: 124 RLYQTDLKEIPVVI--FKNLHHLELLGLTGNHLKCLPKEIVNQTKLREIYLKRNQFEVFP 181
Query: 260 EFPSCSL--LKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERL 317
+ C L L+ + + EN+I + E + HL + + N L +P + L L
Sbjct: 182 Q-ELCVLYTLEIIDLDENKIGAI-PEEIGHLTGLQKFYMASNNLPVLPASLCQCSQLSVL 239
Query: 318 DLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQ 376
DLS+N + S+P S L + + L GN L + R +I + T L YL +
Sbjct: 240 DLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPR-LICRWTSLHLLYLGNTGLHRLRGS 298
Query: 377 SESATETAMTLPSESRVN-----IHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSIN 431
S++ ++ I A+ L++L D + +P E+ K I +
Sbjct: 299 FRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKI---LG 355
Query: 432 FSKNQLCEIPKR---MVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLP 488
+ N+ P+ + L+++ D F KL+++ + LQ L L + NN L LP
Sbjct: 356 LTGNEFLSFPEEVLSLASLEKLYIGQDQGF-KLTYVPEHIRKLQSLKELYIENNHLEYLP 414
Query: 489 EEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLD 548
+ S+ L+ ++ N K LP+ + + + L L
Sbjct: 415 VSLGSMPNLEVLDCRHNLLKQLPDAICQ------------------------AQALKELR 450
Query: 549 LQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRD 598
L++N L +P L + VNL+ L L NP P + +G AI +YL++
Sbjct: 451 LEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKE 500
Score = 150 bits (380), Expect = 2e-36
Identities = 99/290 (34%), Positives = 156/290 (53%), Gaps = 6/290 (2%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
T L K +++N L L L L+VLD+ N L S+P + EL + ++ +S N+L+
Sbjct: 211 TGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLE 270
Query: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
+P I +L LYL + L + F L NL LDLS NHL P +L +L
Sbjct: 271 KVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEV 330
Query: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRN---KLRFL 258
L L N++ LP+E+ + +LK L N + P E+ + SLE LY+ ++ KL ++
Sbjct: 331 LGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYV 390
Query: 259 PE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERL 317
PE LKEL++ N +E L L + ++ VLD R N LK +PD I ++L+ L
Sbjct: 391 PEHIRKLQSLKELYIENNHLEYLPVS-LGSMPNLEVLDCRHNLLKQLPDAICQAQALKEL 449
Query: 318 DLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLR 366
L +N ++ LP +L +L +LK L L NP+ +E+ ++G + + KYL+
Sbjct: 450 RLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLK 499
Score = 131 bits (329), Expect = 2e-30
Identities = 126/478 (26%), Positives = 208/478 (43%), Gaps = 50/478 (10%)
Query: 40 QLNLSGRNLSEVPQCVWRI-NVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKL-QSL 97
+++L + E+PQ + R+ N+ + NL + L L +S N + S
Sbjct: 52 EVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLR-SLCPALGLLSSLESLDLSYNPIFSSS 110
Query: 98 TDDLRLLPALTVLDIHDNQLTSLPSAI-RELENLQKLNVSHNKLKILPEEITNLRNLKCL 156
+ L AL L ++ L +P I + L +L+ L ++ N LK LP+EI N L+ +
Sbjct: 111 LVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTKLREI 170
Query: 157 YLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEI 216
YL+ N+ + L LE +DL N + +P L+ L + ++SN L LPA +
Sbjct: 171 YLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASL 230
Query: 217 NRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGEN 275
+ +L LD + NLL +IP A + + + L N+L +P + L L++G
Sbjct: 231 CQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNT 290
Query: 276 QIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL- 334
+ L + L ++ LDL N L P +I L++LE L L +N I LP LG+L
Sbjct: 291 GLHRLRGS-FRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLS 349
Query: 335 HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVN 394
LK L L GN + E++S + E L Y+ +D G
Sbjct: 350 KLKILGLTGNEFLSFPEEVLSLASLEKL-YIG---QDQG--------------------- 384
Query: 395 IHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDV 454
+ T +P+ + K + + N L +P + + + +
Sbjct: 385 --------------FKLTYVPEHI---RKLQSLKELYIENNHLEYLPVSLGSMPNL-EVL 426
Query: 455 DLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPE 512
D N L + +C Q L L L +N L LPE ++SLV L+ + L N + P+
Sbjct: 427 DCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPK 484
Score = 107 bits (267), Expect = 3e-23
Identities = 87/283 (30%), Positives = 128/283 (45%), Gaps = 28/283 (9%)
Query: 26 SVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLT 85
S+P+ + RK ++ LSG L +VP+ + RW T L
Sbjct: 248 SIPKSFAEL-RKMTEIGLSGNRLEKVPRLIC--------------------RW---TSLH 283
Query: 86 KLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145
L + N L L R L L LD+ N L P I L+NL+ L + NK+ LP
Sbjct: 284 LLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPS 343
Query: 146 EITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNH---LTTVPASFSSLSSLVRL 202
E+ +L LK L L NE E L++LE L + + LT VP L SL L
Sbjct: 344 ELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKLQSLKEL 403
Query: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-F 261
+ +N L+ LP + M L+ LDC NLL+ +P + ++L+ L L N L LPE
Sbjct: 404 YIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLTHLPENL 463
Query: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
S LK L + +N +E E N + L++N+ +++
Sbjct: 464 DSLVNLKVLTLMDNPMEEPPKEVCAEGNEAIWKYLKENRNRNI 506
Score = 100 bits (250), Expect = 3e-21
Identities = 78/270 (28%), Positives = 137/270 (50%), Gaps = 5/270 (1%)
Query: 43 LSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLR 102
++ NL +P + + + + + NL + + E +T++ +S N+L+ + +
Sbjct: 218 MASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLIC 277
Query: 103 LLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNE 162
+L +L + + L L + R L NL+ L++S N L P +I L+NL+ L L N+
Sbjct: 278 RWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNK 337
Query: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNE---LKSLPAEINRM 219
+ + LS L+ L L+ N + P SL+SL +L + ++ L +P I ++
Sbjct: 338 IGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSLASLEKLYIGQDQGFKLTYVPEHIRKL 397
Query: 220 KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIE 278
+ LK L +N LE +P L M +LE+L R N L+ LP+ LKEL + +N +
Sbjct: 398 QSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHNLLKQLPDAICQAQALKELRLEDNLLT 457
Query: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEI 308
L E+L L ++ VL L DN ++ P E+
Sbjct: 458 HL-PENLDSLVNLKVLTLMDNPMEEPPKEV 486
Score = 47.4 bits (111), Expect = 4e-05
Identities = 40/171 (23%), Positives = 72/171 (42%), Gaps = 24/171 (14%)
Query: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEV 513
+D S L+ I LE+ +L + L NN + +P+E++ L ++ + L N + L
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 514 LYRIFTLETILISNNQVGS------------------------VDPQKMKMMENLTTLDL 549
L + +LE++ +S N + S + K + +L L L
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 550 QNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRI 600
N L +P E+ N LR + L N F V + + T I++ ++I
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKI 200
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 149 bits (376), Expect = 7e-36
Identities = 108/333 (32%), Positives = 165/333 (49%), Gaps = 11/333 (3%)
Query: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQT---- 82
VP+ + + AR +L L L E+P+ +++ + LS +R +
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQL----VKLRKLGLSDNEIQRLPPEIANFM 82
Query: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
L +L +S N++ + + + AL V D N LT LP + EL+NL L+V+ L+
Sbjct: 83 QLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQS 142
Query: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
LPE I NL NL L L+ N LT + + QL LE+LDL NN + +P S +L L L
Sbjct: 143 LPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDL 202
Query: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-F 261
L N+L LP EI +K L LD + N LE +P E++G+ SL L + +N L +P+
Sbjct: 203 WLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGI 262
Query: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSN 321
L L V +N++ L E + S+ L L +N+L ++P I L+ L L+
Sbjct: 263 GKLKKLSILKVDQNRLTQL-PEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADR 321
Query: 322 NDISSLPYSLGN-LHLKFLALEGNPLRTIRREI 353
N + SLP +G L + N L I E+
Sbjct: 322 NKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEV 354
Score = 139 bits (350), Expect = 7e-33
Identities = 122/428 (28%), Positives = 203/428 (47%), Gaps = 52/428 (12%)
Query: 151 RNLKCLYLQHNELTCISEG-FEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNEL 209
R+++ + +H L + E + +LE+L L N L +P F L L +L LS NE+
Sbjct: 12 RHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEI 71
Query: 210 KSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLK 268
+ LP EI +L LD + N + IP ++ ++L++ N L LPE FP L
Sbjct: 72 QRLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
Query: 269 ELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLP 328
L V + ++ L E++ +L ++ L+LR+N L +PD + LR LE LDL NN+I +LP
Sbjct: 132 CLSVNDISLQSLP-ENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLP 190
Query: 329 YSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTL 387
S+G L HLK L L+GN L + +EI +K+
Sbjct: 191 ESIGALLHLKDLWLDGNQLSELPQEI-------------GNLKN---------------- 221
Query: 388 PSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVEL 447
L LD S+ + +P+E+ +T + S+N L IP + +L
Sbjct: 222 -------------LLCLDVSENRLERLPEEISGLTS---LTDLVISQNLLETIPDGIGKL 265
Query: 448 KEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRF 507
K++ S + + N+L+ + + + LT L L N L +LP+ + L +L +N N+
Sbjct: 266 KKL-SILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKL 324
Query: 508 KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNL 567
LP+ + +L + +N++ + P ++ L LD+ N LL +P L + L
Sbjct: 325 VSLPKEIGGCCSLTVFCVRDNRLTRI-PAEVSQATELHVLDVAGNRLLHLPLSL-TALKL 382
Query: 568 RTLLLDGN 575
+ L L N
Sbjct: 383 KALWLSDN 390
Score = 101 bits (252), Expect = 2e-21
Identities = 91/365 (24%), Positives = 176/365 (48%), Gaps = 29/365 (7%)
Query: 220 KRLKHLDCNSNLLETIPPELAGM-ESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQI 277
+ ++ +D L +P E+ SLE L L N+LR LPE F L++L + +N+I
Sbjct: 12 RHVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEI 71
Query: 278 EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HL 336
+ L E + + ++ LD+ N++ +P+ I ++L+ D S N ++ LP S L +L
Sbjct: 72 QRLPPE-IANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNL 130
Query: 337 KFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIH 396
L++ L+++ I G L L + E +T +S +
Sbjct: 131 TCLSVNDISLQSLPENI---GNLYNLASLELR-------------ENLLTYLPDSLTQLR 174
Query: 397 AIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDL 456
L+ LD + + +P+ + + + + NQL E+P+ + LK ++ +D+
Sbjct: 175 R---LEELDLGNNEIYNLPESIGALLH---LKDLWLDGNQLSELPQEIGNLKNLLC-LDV 227
Query: 457 SFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYR 516
S N+L + E+ L LT L + N L ++P+ + L +L + + NR LPE +
Sbjct: 228 SENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGE 287
Query: 517 IFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLL-DGN 575
+L ++++ NQ+ ++ P+ + ++ L+ L+ N L+ +P E+G C +L + D
Sbjct: 288 CESLTELVLTENQLLTL-PKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNR 346
Query: 576 PFRVP 580
R+P
Sbjct: 347 LTRIP 351
Score = 99.4 bits (246), Expect = 9e-21
Identities = 66/197 (33%), Positives = 96/197 (48%)
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
L L + N+L L ++ L L LD+ +N+L LP I L +L L +S N L+ +
Sbjct: 199 LKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETI 258
Query: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
P+ I L+ L L + N LT + E + +L +L L+ N L T+P S L L LN
Sbjct: 259 PDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLN 318
Query: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPS 263
N+L SLP EI L N L IP E++ L +L + N+L LP +
Sbjct: 319 ADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLT 378
Query: 264 CSLLKELHVGENQIEML 280
LK L + +NQ + L
Sbjct: 379 ALKLKALWLSDNQSQPL 395
Score = 89.7 bits (221), Expect = 7e-18
Identities = 59/188 (31%), Positives = 97/188 (51%), Gaps = 1/188 (0%)
Query: 43 LSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLR 102
L G LSE+PQ + + + + ++N E T LT L+IS N L+++ D +
Sbjct: 204 LDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIG 263
Query: 103 LLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNE 162
L L++L + N+LT LP A+ E E+L +L ++ N+L LP+ I L+ L L N+
Sbjct: 264 KLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNK 323
Query: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
L + + +L + +N LT +PA S + L L+++ N L LP + +K L
Sbjct: 324 LVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALK-L 382
Query: 223 KHLDCNSN 230
K L + N
Sbjct: 383 KALWLSDN 390
Score = 55.1 bits (131), Expect = 2e-07
Identities = 48/172 (27%), Positives = 76/172 (44%), Gaps = 24/172 (13%)
Query: 41 LNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDD 100
L +S L +P + ++ + +QN E E LT+L+++
Sbjct: 248 LVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLT---------- 297
Query: 101 LRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQH 160
+NQL +LP +I +L+ L LN NKL LP+EI +L ++
Sbjct: 298 -------------ENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRD 344
Query: 161 NELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSL 212
N LT I Q + L LD++ N L +P S ++L L L LS N+ + L
Sbjct: 345 NRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQSQPL 395
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 149 bits (375), Expect = 9e-36
Identities = 118/377 (31%), Positives = 187/377 (49%), Gaps = 46/377 (12%)
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
L +L + N+++ L L +L L + DN LT+LP++I L NL++L+VS N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
PE I N + L + N ++ + +GF QL NL L L++ L +PA+F L+ L L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF-P 262
L N+LK LP +NR+ +L+ LD SN +P L + L+ ++ N+L F+P F
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227
Query: 263 SCSLLKELHVGENQIEMLE----------------------AEHLKHLNSILVLDLRDNK 300
S L L V +N IEM+E E + L +I L + +N+
Sbjct: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
Query: 301 LKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQ 359
L +PD I L S+E LD S N++ +LP S+G L +L+ A + N L+ + EI S
Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347
Query: 360 EVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVF 419
VL +K++ TLP E + + LK+++ SD + +P F
Sbjct: 348 TVLFLHSNKLE---------------TLPEE----MGDMQKLKVINLSDNRLKNLP---F 385
Query: 420 DAVKSNIVTSINFSKNQ 436
K +T++ S NQ
Sbjct: 386 SFTKLQQLTAMWLSDNQ 402
Score = 132 bits (332), Expect = 9e-31
Identities = 122/442 (27%), Positives = 208/442 (47%), Gaps = 39/442 (8%)
Query: 126 ELENLQKLNVSHNKLKILPEEI-TNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184
E E + L+ SH L+ +P+EI T + L+ LYL N++ + + +L L L +N
Sbjct: 20 EEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDN 79
Query: 185 HLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMES 244
LTT+PAS ++L +L L++S N ++ P I K L ++ + N + +P + + +
Sbjct: 80 DLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLN 139
Query: 245 LELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
L LYL L FLP + L + +L+LR+N+LK +
Sbjct: 140 LTQLYLNDAFLEFLPA-----------------------NFGRLTKLQILELRENQLKML 176
Query: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363
P + L LERLDL +N+ + +P L L LK ++ N L I I S L
Sbjct: 177 PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLD 236
Query: 364 YLRSKIK--DDGPSQSESATETAMTLPS-----ESRVNIHAIITLKILDYSDKQATLIPD 416
++ I+ ++G S E+ + ++ S E+ ++ I TLKI + Q +PD
Sbjct: 237 VSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKI---DENQLMYLPD 293
Query: 417 EVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTF 476
+ + V ++ S N++ +P + +L + + N L + E+ + +T
Sbjct: 294 SIGGLIS---VEELDCSFNEVEALPSSIGQLTNLRTFA-ADHNYLQQLPPEIGSWKNITV 349
Query: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQ 536
L L +N L +LPEEM + +L+ INLS NR K LP ++ L + +S+NQ + P
Sbjct: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409
Query: 537 KMKMMENLTTLDLQNNDLLQIP 558
+ + + L N Q P
Sbjct: 410 QKETDSETQKMVLTNYMFPQQP 431
Score = 112 bits (280), Expect = 1e-24
Identities = 74/246 (30%), Positives = 123/246 (50%), Gaps = 23/246 (9%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
T L +L + +N+ + + L L L + N+LT +P I L+ L L+VS N ++
Sbjct: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243
Query: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
++ E I+ NL+ L L N L + E L N+ L + N L +P S L S+
Sbjct: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
Query: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF 261
L+ S NE+++LP+ I ++ L+ + N L+ +PPE+ +++ +L+L NKL LPE
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE- 362
Query: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSN 321
EM + + LK V++L DN+LK++P L+ L + LS+
Sbjct: 363 ----------------EMGDMQKLK------VINLSDNRLKNLPFSFTKLQQLTAMWLSD 400
Query: 322 NDISSL 327
N L
Sbjct: 401 NQSKPL 406
Score = 98.2 bits (243), Expect = 2e-20
Identities = 94/381 (24%), Positives = 170/381 (44%), Gaps = 51/381 (13%)
Query: 198 SLVRLNLSSNELKSLPAEINRM-KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 256
++ L+ S L+ +P EI K L+ L ++N +E +P +L +SL L L N L
Sbjct: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
Query: 257 FLP-EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLE 315
LP + L+EL V +N I+ E++K+ + +++ N + +PD L +L
Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
Query: 316 RLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGP 374
+L L++ + LP + G L L+ L L N L+ + +
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPK----------------------- 178
Query: 375 SQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK 434
++ + L+ LD + T +P EV + + +
Sbjct: 179 -------------------TMNRLTQLERLDLGSNEFTEVP-EVLEQLSG--LKEFWMDA 216
Query: 435 NQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESL 494
N+L IP + LK++ +D+S N + + + + L L L +N L LPE + SL
Sbjct: 217 NRLTFIPGFIGSLKQLTY-LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSL 275
Query: 495 VRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL 554
+ T+ + N+ LP+ + + ++E + S N+V ++ P + + NL T +N L
Sbjct: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEAL-PSSIGQLTNLRTFAADHNYL 334
Query: 555 LQIPPELGNCVNLRTLLLDGN 575
Q+PPE+G+ N+ L L N
Sbjct: 335 QQLPPEIGSWKNITVLFLHSN 355
Score = 84.7 bits (208), Expect = 2e-16
Identities = 49/155 (31%), Positives = 82/155 (52%)
Query: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
+L L++S+N LQ L + + L +T L I +NQL LP +I L ++++L+ S N+++
Sbjct: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEA 313
Query: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
LP I L NL+ HN L + N+ L L +N L T+P + L +
Sbjct: 314 LPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVI 373
Query: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP 237
NLS N LK+LP ++++L + + N + + P
Sbjct: 374 NLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP 408
Score = 41.2 bits (95), Expect = 0.003
Identities = 26/106 (24%), Positives = 54/106 (50%), Gaps = 2/106 (1%)
Query: 472 QKLTFLDLRNNFLNSLPEEMESLVR-LQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530
+ +T LD + L +P+E+ + + L+ + L N+ + LP+ L+ +L + + +N +
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
Query: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNP 576
++ P + + NL LD+ N + + P + NC L + NP
Sbjct: 82 TTL-PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNP 126
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 149 bits (375), Expect = 9e-36
Identities = 118/377 (31%), Positives = 187/377 (49%), Gaps = 46/377 (12%)
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
L +L + N+++ L L +L L + DN LT+LP++I L NL++L+VS N ++
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
PE I N + L + N ++ + +GF QL NL L L++ L +PA+F L+ L L
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF-P 262
L N+LK LP +NR+ +L+ LD SN +P L + L+ ++ N+L F+P F
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIG 227
Query: 263 SCSLLKELHVGENQIEMLE----------------------AEHLKHLNSILVLDLRDNK 300
S L L V +N IEM+E E + L +I L + +N+
Sbjct: 228 SLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQ 287
Query: 301 LKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQ 359
L +PD I L S+E LD S N++ +LP S+G L +L+ A + N L+ + EI S
Sbjct: 288 LMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNI 347
Query: 360 EVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVF 419
VL +K++ TLP E + + LK+++ SD + +P F
Sbjct: 348 TVLFLHSNKLE---------------TLPEE----MGDMQKLKVINLSDNRLKNLP---F 385
Query: 420 DAVKSNIVTSINFSKNQ 436
K +T++ S NQ
Sbjct: 386 SFTKLQQLTAMWLSDNQ 402
Score = 132 bits (332), Expect = 9e-31
Identities = 122/442 (27%), Positives = 208/442 (47%), Gaps = 39/442 (8%)
Query: 126 ELENLQKLNVSHNKLKILPEEI-TNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184
E E + L+ SH L+ +P+EI T + L+ LYL N++ + + +L L L +N
Sbjct: 20 EEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDN 79
Query: 185 HLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMES 244
LTT+PAS ++L +L L++S N ++ P I K L ++ + N + +P + + +
Sbjct: 80 DLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLN 139
Query: 245 LELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
L LYL L FLP + L + +L+LR+N+LK +
Sbjct: 140 LTQLYLNDAFLEFLPA-----------------------NFGRLTKLQILELRENQLKML 176
Query: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363
P + L LERLDL +N+ + +P L L LK ++ N L I I S L
Sbjct: 177 PKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLD 236
Query: 364 YLRSKIK--DDGPSQSESATETAMTLPS-----ESRVNIHAIITLKILDYSDKQATLIPD 416
++ I+ ++G S E+ + ++ S E+ ++ I TLKI + Q +PD
Sbjct: 237 VSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKI---DENQLMYLPD 293
Query: 417 EVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTF 476
+ + V ++ S N++ +P + +L + + N L + E+ + +T
Sbjct: 294 SIGGLIS---VEELDCSFNEVEALPSSIGQLTNLRTFA-ADHNYLQQLPPEIGSWKNITV 349
Query: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQ 536
L L +N L +LPEEM + +L+ INLS NR K LP ++ L + +S+NQ + P
Sbjct: 350 LFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIPL 409
Query: 537 KMKMMENLTTLDLQNNDLLQIP 558
+ + + L N Q P
Sbjct: 410 QKETDSETQKMVLTNYMFPQQP 431
Score = 112 bits (280), Expect = 1e-24
Identities = 74/246 (30%), Positives = 123/246 (50%), Gaps = 23/246 (9%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
T L +L + +N+ + + L L L + N+LT +P I L+ L L+VS N ++
Sbjct: 184 TQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIE 243
Query: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
++ E I+ NL+ L L N L + E L N+ L + N L +P S L S+
Sbjct: 244 MVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEE 303
Query: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEF 261
L+ S NE+++LP+ I ++ L+ + N L+ +PPE+ +++ +L+L NKL LPE
Sbjct: 304 LDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPE- 362
Query: 262 PSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSN 321
EM + + LK V++L DN+LK++P L+ L + LS+
Sbjct: 363 ----------------EMGDMQKLK------VINLSDNRLKNLPFSFTKLQQLTAMWLSD 400
Query: 322 NDISSL 327
N L
Sbjct: 401 NQSKPL 406
Score = 98.2 bits (243), Expect = 2e-20
Identities = 94/381 (24%), Positives = 170/381 (44%), Gaps = 51/381 (13%)
Query: 198 SLVRLNLSSNELKSLPAEINRM-KRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLR 256
++ L+ S L+ +P EI K L+ L ++N +E +P +L +SL L L N L
Sbjct: 23 TVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLT 82
Query: 257 FLP-EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLE 315
LP + L+EL V +N I+ E++K+ + +++ N + +PD L +L
Sbjct: 83 TLPASIANLINLRELDVSKNGIQEFP-ENIKNCKVLTIVEASVNPISKLPDGFSQLLNLT 141
Query: 316 RLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGP 374
+L L++ + LP + G L L+ L L N L+ + +
Sbjct: 142 QLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPK----------------------- 178
Query: 375 SQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSK 434
++ + L+ LD + T +P EV + + +
Sbjct: 179 -------------------TMNRLTQLERLDLGSNEFTEVP-EVLEQLSG--LKEFWMDA 216
Query: 435 NQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESL 494
N+L IP + LK++ +D+S N + + + + L L L +N L LPE + SL
Sbjct: 217 NRLTFIPGFIGSLKQLTY-LDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSL 275
Query: 495 VRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL 554
+ T+ + N+ LP+ + + ++E + S N+V ++ P + + NL T +N L
Sbjct: 276 KNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEAL-PSSIGQLTNLRTFAADHNYL 334
Query: 555 LQIPPELGNCVNLRTLLLDGN 575
Q+PPE+G+ N+ L L N
Sbjct: 335 QQLPPEIGSWKNITVLFLHSN 355
Score = 84.7 bits (208), Expect = 2e-16
Identities = 49/155 (31%), Positives = 82/155 (52%)
Query: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
+L L++S+N LQ L + + L +T L I +NQL LP +I L ++++L+ S N+++
Sbjct: 254 NLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEA 313
Query: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
LP I L NL+ HN L + N+ L L +N L T+P + L +
Sbjct: 314 LPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKLKVI 373
Query: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP 237
NLS N LK+LP ++++L + + N + + P
Sbjct: 374 NLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLIP 408
Score = 41.2 bits (95), Expect = 0.003
Identities = 26/106 (24%), Positives = 54/106 (50%), Gaps = 2/106 (1%)
Query: 472 QKLTFLDLRNNFLNSLPEEMESLVR-LQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530
+ +T LD + L +P+E+ + + L+ + L N+ + LP+ L+ +L + + +N +
Sbjct: 22 ETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEELPKQLFNCQSLHKLSLPDNDL 81
Query: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNP 576
++ P + + NL LD+ N + + P + NC L + NP
Sbjct: 82 TTL-PASIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNP 126
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 139 bits (349), Expect = 1e-32
Identities = 87/228 (38%), Positives = 134/228 (58%), Gaps = 2/228 (0%)
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
L +L +S N+L L D L L L LD+ NQLT+ P + +L L++L+VS N+L+ L
Sbjct: 160 LEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGL 219
Query: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
PE+I+ LR LK L+L EL + GF +L++LE L L NN L +PA FS L L LN
Sbjct: 220 PEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLN 279
Query: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FP 262
LSSN + PA + + L+ L + N L ++P ++G+ L L+L N++R+LP+
Sbjct: 280 LSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIV 339
Query: 263 SCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL 310
+ L+EL + NQI +L +H L+ + + ++DN L P E+ +
Sbjct: 340 ELTGLEELVLQGNQIAVL-PDHFGQLSRVGLWKIKDNPLIQPPYEVCM 386
Score = 137 bits (346), Expect = 2e-32
Identities = 109/342 (31%), Positives = 162/342 (47%), Gaps = 28/342 (8%)
Query: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPE---EANQNLSFGATERWWEQTD 83
VP+GL A L L + +P V + + E N+ + GA E +
Sbjct: 78 VPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGA-EVVSALRE 136
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
L KL +S+N+L +L L L L LD+ N+L LP ++ L L+ L+V HN+L
Sbjct: 137 LRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAF 196
Query: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
P ++ L L+ L + N L + E L L+ L LS L T+PA F L+SL L
Sbjct: 197 PRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLM 256
Query: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPS 263
L +N L++LPA+ + ++RLK L+ +SNL E P L + LE LYL RN+L +P
Sbjct: 257 LDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSL-- 314
Query: 264 CSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNND 323
+ L +L L L +N+++ +PD I+ L LE L L N
Sbjct: 315 ---------------------ISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ 353
Query: 324 ISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKY 364
I+ LP G L + ++ NPL E+ KG + Y
Sbjct: 354 IAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAY 395
Score = 93.6 bits (231), Expect = 5e-19
Identities = 102/371 (27%), Positives = 158/371 (42%), Gaps = 75/371 (20%)
Query: 212 LPAEINRMKRLKHLDCNSNLLETIPPEL-AGMESLELLYLRRNKLRFLPEFPSCSLLKEL 270
LPA + ++ L + +N LE +P L + + SL +L LRRN+ LP
Sbjct: 58 LPANLGDIEAL---NLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPP---------- 104
Query: 271 HVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEII-LLRSLERLDLSNNDISSLPY 329
AE HL LD+ N+L ++ E++ LR L +L+LS+N + +LP
Sbjct: 105 ---------AVAELGHHLTE---LDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPA 152
Query: 330 SLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLP 388
LG L HL+ L + N L LP
Sbjct: 153 QLGALAHLEELDVSFNRLAH--------------------------------------LP 174
Query: 389 SESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELK 448
++ + L+ LD Q T P ++ V + ++ S N+L +P+ + L+
Sbjct: 175 D----SLSCLSRLRTLDVDHNQLTAFPRQLLQLVA---LEELDVSSNRLRGLPEDISALR 227
Query: 449 EMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFK 508
+ + LS +L + C L L L L NN L +LP + L RL+ +NLS N F+
Sbjct: 228 AL-KILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFE 286
Query: 509 MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLR 568
P L + LE + +S NQ+ SV P + + L TL L NN + +P + L
Sbjct: 287 EFPAALLPLAGLEELYLSRNQLTSV-PSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLE 345
Query: 569 TLLLDGNPFRV 579
L+L GN V
Sbjct: 346 ELVLQGNQIAV 356
Score = 82.0 bits (201), Expect = 1e-15
Identities = 72/275 (26%), Positives = 127/275 (46%), Gaps = 43/275 (15%)
Query: 311 LRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIK 370
L +E L+L NN + +P LG+ + G+ VL R++
Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGS---------------------ALGSLRVLVLRRNRF- 99
Query: 371 DDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSI 430
A P+ + + H L LD S + T + EV A++ + +
Sbjct: 100 -------------ARLPPAVAELGHH----LTELDVSHNRLTALGAEVVSALRE--LRKL 140
Query: 431 NFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEE 490
N S NQL +P ++ L + ++D+SFN+L+ + L L +L LD+ +N L + P +
Sbjct: 141 NLSHNQLPALPAQLGALAHL-EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQ 199
Query: 491 MESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQ 550
+ LV L+ +++S NR + LPE + + L+ + +S ++G++ P + +L +L L
Sbjct: 200 LLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTL-PAGFCELASLESLMLD 258
Query: 551 NNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAIL 585
NN L +P + L+ L L N F AA+L
Sbjct: 259 NNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293
Score = 80.9 bits (198), Expect = 3e-15
Identities = 95/345 (27%), Positives = 153/345 (44%), Gaps = 52/345 (15%)
Query: 173 LSNLEDLDLSNNHLTTVPASF-SSLSSLVRLNLSSNELKSLPAEINRM-KRLKHLDCNSN 230
L ++E L+L NN L VP S+L SL L L N LP + + L LD + N
Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
Query: 231 LLETIPPEL-AGMESLELLYLRRNKLRFLP-EFPSCSLLKELHVGENQIEMLEAEHLKHL 288
L + E+ + + L L L N+L LP + + + L+EL V N++ L + L L
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP-DSLSCL 180
Query: 289 NSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLR 347
+ + LD+ N+L + P +++ L +LE LD+S+N + LP + L LK L L G L
Sbjct: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240
Query: 348 TIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYS 407
T+ L L S + D+ Q+ LP++ + LK+L
Sbjct: 241 TLPAGFCE------LASLESLMLDNNGLQA---------LPAQ----FSCLQRLKML--- 278
Query: 408 DKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLE 467
N S N E P ++ L + ++ LS N+L+ +
Sbjct: 279 -----------------------NLSSNLFEEFPAALLPLAGL-EELYLSRNQLTSVPSL 314
Query: 468 LCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPE 512
+ L +L L L NN + LP+ + L L+ + L N+ +LP+
Sbjct: 315 ISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPD 359
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 139 bits (349), Expect = 1e-32
Identities = 117/415 (28%), Positives = 192/415 (46%), Gaps = 54/415 (13%)
Query: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQ----CVWRINVDIPEEANQNLSFGATERWWEQT 82
VP+ + R +L L + E+P+ C + IP+ NL
Sbjct: 37 VPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASL----V 92
Query: 83 DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
+L +L IS N +Q ++++ LT+++ N ++ LP +L NL +L ++ L+
Sbjct: 93 NLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEF 152
Query: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
LP L L+ L L+ N L + + +L+ LE LDL NN +P + +L L
Sbjct: 153 LPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLREL 212
Query: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFP 262
+ +N L+ LP I ++K L +LD + N +ET+ +++G E+LE L L N L+ LP+
Sbjct: 213 WMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPD-- 270
Query: 263 SCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNN 322
S LLK+L L + DN+L +P+ I L LE D S N
Sbjct: 271 SIGLLKKL---------------------TTLKVDDNQLTMLPNTIGNLSLLEEFDCSCN 309
Query: 323 DISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESAT 381
++ SLP ++G LH L+ LA++ N L + REI S V+ +K++
Sbjct: 310 ELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLE----------- 358
Query: 382 ETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQ 436
LP E I + L++L+ SD + +P F K + ++ S NQ
Sbjct: 359 ----FLPEE----IGQMQKLRVLNLSDNRLKNLP---FSFTKLKELAALWLSDNQ 402
Score = 130 bits (327), Expect = 3e-30
Identities = 113/419 (26%), Positives = 199/419 (47%), Gaps = 39/419 (9%)
Query: 126 ELENLQKLNVSHNKLKILPEEITNL-RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNN 184
E E + L+ SH L+ +P+E+ N R L+ LYL N++ + + L L + +N
Sbjct: 20 EEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDN 79
Query: 185 HLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMES 244
L+ +P + +SL +L L++S N ++ P I K L ++ + N + +P + +
Sbjct: 80 DLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLN 139
Query: 245 LELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
L LYL L FLP + L + +L+LR+N LK++
Sbjct: 140 LTQLYLNDAFLEFLPA-----------------------NFGRLVKLRILELRENHLKTL 176
Query: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLK 363
P + L LERLDL NN+ LP L + +L+ L ++ N L+ + I G ++L
Sbjct: 177 PKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSI---GKLKMLV 233
Query: 364 YL-RSKIKDDGPSQSESATETAMTLPSESRV------NIHAIITLKILDYSDKQATLIPD 416
YL SK + + S E L S + +I + L L D Q T++P+
Sbjct: 234 YLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPN 293
Query: 417 EVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTF 476
+ + +++ + S N+L +P + L + + + + N L + E+ + +T
Sbjct: 294 TIGNL---SLLEEFDCSCNELESLPSTIGYLHSLRT-LAVDENFLPELPREIGSCKNVTV 349
Query: 477 LDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDP 535
+ LR+N L LPEE+ + +L+ +NLS NR K LP ++ L + +S+NQ ++ P
Sbjct: 350 MSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIP 408
Score = 101 bits (251), Expect = 2e-21
Identities = 99/395 (25%), Positives = 186/395 (47%), Gaps = 29/395 (7%)
Query: 202 LNLSSNELKSLPAEINRMKR-LKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE 260
L+ S L+ +P E+ +R L+ L ++N +E +P +L ++L L + N L LP
Sbjct: 27 LDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPT 86
Query: 261 -FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDL 319
S LKEL + +N ++ E++K + +++ N + +PD L +L +L L
Sbjct: 87 TIASLVNLKELDISKNGVQEFP-ENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYL 145
Query: 320 SNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSE 378
++ + LP + G L L+ L L N L+T+ + + E L D G ++
Sbjct: 146 NDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERL--------DLGNNEFG 197
Query: 379 SATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLC 438
E + I L+ L + ++P + K ++ ++ SKN++
Sbjct: 198 ELPEV-----------LDQIQNLRELWMDNNALQVLPGSIG---KLKMLVYLDMSKNRI- 242
Query: 439 EIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQ 498
E + E + D+ LS N L + + +L+KLT L + +N L LP + +L L+
Sbjct: 243 ETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLE 302
Query: 499 TINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIP 558
+ S N + LP + + +L T+ + N + + P+++ +N+T + L++N L +P
Sbjct: 303 EFDCSCNELESLPSTIGYLHSLRTLAVDENFLPEL-PREIGSCKNVTVMSLRSNKLEFLP 361
Query: 559 PELGNCVNLRTLLLDGNPFR-VPRAAILMKGTAAI 592
E+G LR L L N + +P + +K AA+
Sbjct: 362 EEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAAL 396
Score = 101 bits (251), Expect = 2e-21
Identities = 72/214 (33%), Positives = 107/214 (50%), Gaps = 2/214 (0%)
Query: 69 NLSFGATERWWEQT-DLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIREL 127
N FG +Q +L +L + NN LQ L + L L LD+ N++ ++ I
Sbjct: 193 NNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGC 252
Query: 128 ENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLT 187
E L+ L +S N L+ LP+ I L+ L L + N+LT + LS LE+ D S N L
Sbjct: 253 EALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELE 312
Query: 188 TVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLEL 247
++P++ L SL L + N L LP EI K + + SN LE +P E+ M+ L +
Sbjct: 313 SLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRV 372
Query: 248 LYLRRNKLRFLP-EFPSCSLLKELHVGENQIEML 280
L L N+L+ LP F L L + +NQ + L
Sbjct: 373 LNLSDNRLKNLPFSFTKLKELAALWLSDNQSKAL 406
Score = 89.7 bits (221), Expect = 7e-18
Identities = 54/154 (35%), Positives = 80/154 (51%)
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
L L++S+N LQ L D + LL LT L + DNQLT LP+ I L L++ + S N+L+ L
Sbjct: 255 LEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESL 314
Query: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
P I L +L+ L + N L + N+ + L +N L +P + L LN
Sbjct: 315 PSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLN 374
Query: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP 237
LS N LK+LP ++K L L + N + + P
Sbjct: 375 LSDNRLKNLPFSFTKLKELAALWLSDNQSKALIP 408
Score = 63.5 bits (153), Expect = 5e-10
Identities = 56/225 (24%), Positives = 96/225 (42%), Gaps = 27/225 (12%)
Query: 401 LKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNK 460
+ +LDYS +P EVF+ ++ + + NQ+ E+PK++ + + + + N
Sbjct: 24 ISVLDYSHCSLQQVPKEVFNFERT--LEELYLDANQIEELPKQLFNCQAL-RKLSIPDND 80
Query: 461 LSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPE-------- 512
LS + + L L LD+ N + PE ++ L I S N LP+
Sbjct: 81 LSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNL 140
Query: 513 -VLY--------------RIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQI 557
LY R+ L + + N + ++ P+ M + L LDL NN+ ++
Sbjct: 141 TQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEFGEL 199
Query: 558 PPELGNCVNLRTLLLDGNPFRVPRAAILMKGTAAILEYLRDRIPT 602
P L NLR L +D N +V +I L+ ++RI T
Sbjct: 200 PEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIET 244
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 138 bits (347), Expect = 2e-32
Identities = 114/381 (29%), Positives = 194/381 (50%), Gaps = 12/381 (3%)
Query: 40 QLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLT 98
+L++S ++ E+P+ + ++I + + LS + + + L L +++ LQ+L
Sbjct: 86 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLS-RLPDGFTQLRSLAHLALNDVSLQALP 144
Query: 99 DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYL 158
D+ L L L++ +N L SLP+++ L L++L++ N L++LP+ + L NL+ L+L
Sbjct: 145 GDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204
Query: 159 QHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINR 218
N+L+ + L L LD+S N L +PA L L L LS N L+ LP I +
Sbjct: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
Query: 219 MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQI 277
+K+L L + N L + + E+L L L N L LP + L L+V N +
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Query: 278 EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLK 337
E L E + ++ VL LRDN+L +P E+ L LD++ N + SLP++L +L+LK
Sbjct: 325 EALPPE-IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLK 383
Query: 338 FLALEGN---PLRTIRREIISKGTQEVLK-YL---RSKIKDDGPSQSESATETAMTLPSE 390
L L N P+ + E ++ ++VL YL + + + Q S +ET P
Sbjct: 384 ALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAP-P 442
Query: 391 SRVNIHAIITLKILDYSDKQA 411
SRV++ + I D ++A
Sbjct: 443 SRVSVIQFLEAPIGDEDAEEA 463
Score = 127 bits (320), Expect = 2e-29
Identities = 112/397 (28%), Positives = 197/397 (49%), Gaps = 28/397 (7%)
Query: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLS-NLEDLDLSNNHLTTVPASFSSLSS 198
LK +P N R+++ + +H L + E + S +LE+L L N L +P F L +
Sbjct: 2 LKCIPLWRCN-RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
Query: 199 LVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFL 258
L +L LS NE++ LP E+ +L LD + N + IP + ++LE+ N L L
Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
Query: 259 PE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERL 317
P+ F L L + + ++ L + + +L +++ L+LR+N LKS+P + L LE+L
Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGD-VGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
Query: 318 DLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQ 376
DL ND+ LP +LG L +L+ L L+ N L + E+ + L +++++
Sbjct: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE----- 234
Query: 377 SESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQ 436
LP+E + ++ L L S +PD + + +I + +N+
Sbjct: 235 ----------LPAE----LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSI---LKVDQNR 277
Query: 437 LCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496
LCE+ + + + E +S++ L+ N L + L L KLT L++ N L +LP E+ V
Sbjct: 278 LCEVTEAIGDC-ENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336
Query: 497 LQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSV 533
L ++L NR +LP L L + ++ N++ S+
Sbjct: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
Score = 103 bits (256), Expect = 6e-22
Identities = 95/363 (26%), Positives = 171/363 (47%), Gaps = 28/363 (7%)
Query: 220 KRLKHLDCNSNLLETIPPELAGME-SLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQI 277
+ ++ +D L+ +P E+ SLE L L N+LR LP+ F L++L + +N+I
Sbjct: 12 RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEI 71
Query: 278 EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-L 336
+ L E + + ++ LD+ N + +P+ I ++LE D S N +S LP L L
Sbjct: 72 QRLPPE-VANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSL 130
Query: 337 KFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIH 396
LAL L+ + ++ + L+ + +K +LP+ ++
Sbjct: 131 AHLALNDVSLQALPGDVGNLANLVTLELRENLLK---------------SLPA----SLS 171
Query: 397 AIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDL 456
++ L+ LD ++PD + N+ + +NQL +P + L+ +V +D+
Sbjct: 172 FLVKLEQLDLGGNDLEVLPDTL--GALPNL-RELWLDRNQLSALPPELGNLRRLVC-LDV 227
Query: 457 SFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYR 516
S N+L + EL L LT L L N L LP+ + L +L + + NR + E +
Sbjct: 228 SENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Query: 517 IFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNP 576
L ++++ N + ++ P+ + + LT L++ N L +PPE+G CV L L L N
Sbjct: 288 CENLSELILTENLLMAL-PRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNR 346
Query: 577 FRV 579
V
Sbjct: 347 LAV 349
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 138 bits (347), Expect = 2e-32
Identities = 114/381 (29%), Positives = 194/381 (50%), Gaps = 12/381 (3%)
Query: 40 QLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLT 98
+L++S ++ E+P+ + ++I + + LS + + + L L +++ LQ+L
Sbjct: 86 ELDVSRNDIPEIPESIKFCKALEIADFSGNPLS-RLPDGFTQLRSLAHLALNDVSLQALP 144
Query: 99 DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYL 158
D+ L L L++ +N L SLP+++ L L++L++ N L++LP+ + L NL+ L+L
Sbjct: 145 GDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWL 204
Query: 159 QHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINR 218
N+L+ + L L LD+S N L +PA L L L LS N L+ LP I +
Sbjct: 205 DRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQ 264
Query: 219 MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQI 277
+K+L L + N L + + E+L L L N L LP + L L+V N +
Sbjct: 265 LKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHL 324
Query: 278 EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLK 337
E L E + ++ VL LRDN+L +P E+ L LD++ N + SLP++L +L+LK
Sbjct: 325 EALPPE-IGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLK 383
Query: 338 FLALEGN---PLRTIRREIISKGTQEVLK-YL---RSKIKDDGPSQSESATETAMTLPSE 390
L L N P+ + E ++ ++VL YL + + + Q S +ET P
Sbjct: 384 ALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAP-P 442
Query: 391 SRVNIHAIITLKILDYSDKQA 411
SRV++ + I D ++A
Sbjct: 443 SRVSVIQFLEAPIGDEDAEEA 463
Score = 127 bits (320), Expect = 2e-29
Identities = 112/397 (28%), Positives = 197/397 (49%), Gaps = 28/397 (7%)
Query: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLS-NLEDLDLSNNHLTTVPASFSSLSS 198
LK +P N R+++ + +H L + E + S +LE+L L N L +P F L +
Sbjct: 2 LKCIPLWRCN-RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLN 60
Query: 199 LVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFL 258
L +L LS NE++ LP E+ +L LD + N + IP + ++LE+ N L L
Sbjct: 61 LRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRL 120
Query: 259 PE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERL 317
P+ F L L + + ++ L + + +L +++ L+LR+N LKS+P + L LE+L
Sbjct: 121 PDGFTQLRSLAHLALNDVSLQALPGD-VGNLANLVTLELRENLLKSLPASLSFLVKLEQL 179
Query: 318 DLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQ 376
DL ND+ LP +LG L +L+ L L+ N L + E+ + L +++++
Sbjct: 180 DLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEE----- 234
Query: 377 SESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQ 436
LP+E + ++ L L S +PD + + +I + +N+
Sbjct: 235 ----------LPAE----LGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSI---LKVDQNR 277
Query: 437 LCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496
LCE+ + + + E +S++ L+ N L + L L KLT L++ N L +LP E+ V
Sbjct: 278 LCEVTEAIGDC-ENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVA 336
Query: 497 LQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSV 533
L ++L NR +LP L L + ++ N++ S+
Sbjct: 337 LSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
Score = 103 bits (256), Expect = 6e-22
Identities = 95/363 (26%), Positives = 171/363 (47%), Gaps = 28/363 (7%)
Query: 220 KRLKHLDCNSNLLETIPPELAGME-SLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQI 277
+ ++ +D L+ +P E+ SLE L L N+LR LP+ F L++L + +N+I
Sbjct: 12 RHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEI 71
Query: 278 EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-L 336
+ L E + + ++ LD+ N + +P+ I ++LE D S N +S LP L L
Sbjct: 72 QRLPPE-VANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSL 130
Query: 337 KFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIH 396
LAL L+ + ++ + L+ + +K +LP+ ++
Sbjct: 131 AHLALNDVSLQALPGDVGNLANLVTLELRENLLK---------------SLPA----SLS 171
Query: 397 AIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDL 456
++ L+ LD ++PD + N+ + +NQL +P + L+ +V +D+
Sbjct: 172 FLVKLEQLDLGGNDLEVLPDTL--GALPNL-RELWLDRNQLSALPPELGNLRRLVC-LDV 227
Query: 457 SFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYR 516
S N+L + EL L LT L L N L LP+ + L +L + + NR + E +
Sbjct: 228 SENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGD 287
Query: 517 IFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNP 576
L ++++ N + ++ P+ + + LT L++ N L +PPE+G CV L L L N
Sbjct: 288 CENLSELILTENLLMAL-PRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNR 346
Query: 577 FRV 579
V
Sbjct: 347 LAV 349
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 131 bits (330), Expect = 2e-30
Identities = 146/529 (27%), Positives = 237/529 (44%), Gaps = 77/529 (14%)
Query: 76 ERWWEQTDLTKLIISNNKLQ----SLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQ 131
E + D+T L + +N +Q D L L L++ N+L P + E+ L
Sbjct: 266 EHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSHNKLGLFPILLCEISTLT 325
Query: 132 KLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPA 191
+LN+S N LP +I NL NL+ L L N LT + E L L L +S N+ + +P
Sbjct: 326 ELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGISFNNFSQIPE 385
Query: 192 SFSSLSSLVRLNLSSNELKSLP-AEINRMKRLKHLDCNSNLLETIPPE-LAGMESLELLY 249
+ L+ L R+ ++ N L+ L +NRM +KH+D N L+T+ E L G + + +
Sbjct: 386 VYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLKTMVIENLEGNKHITHVD 445
Query: 250 LRRNKLRFLPEFPSCSLLKELHVGENQI-----------------EMLEAEHLKHLNSIL 292
LR N+L L CS L++LH G NQ+ L A ++ + S+L
Sbjct: 446 LRDNRLTDLDLSSLCS-LEQLHCGRNQLRELTLSGFSLRTLYASSNRLTAVNVYPVPSLL 504
Query: 293 V-LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYS-LGNLHLKFLALEGNPLRTIR 350
LDL N L+ VPD + +E LD+S N ++ +P L +L L+ L L N ++ +
Sbjct: 505 TFLDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNL- 563
Query: 351 REIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQ 410
P+ E I L++LD
Sbjct: 564 -----------------------PTLVEH-------------------IPLEVLDLQHNA 581
Query: 411 ATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMV--ELKEMVSDVDLSFNKLSFISLEL 468
T +PD +F K+ + +N S N L +P E M+ + L+ N L+ + +
Sbjct: 582 LTRLPDTLFS--KALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTDQCIPV 639
Query: 469 CVLQ-KLTFLDLRNNFLNSLP-EEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILIS 526
V L L L NN L + P ++ L +L+ +NLS N+ K +P + L T++
Sbjct: 640 LVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAH 699
Query: 527 NNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
+N + S+ P+ +++ + + +DL NDL +I L+ L L GN
Sbjct: 700 SNNI-SIFPEILQLPQ-IQFVDLSCNDLTEILIPEALPATLQDLDLTGN 746
Score = 119 bits (298), Expect = 8e-27
Identities = 129/493 (26%), Positives = 213/493 (43%), Gaps = 85/493 (17%)
Query: 128 ENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEG----FEQLSNLEDLDLSN 183
+ + +++S L+ +PE + +++ L L+HN + G + S L+ L+LS+
Sbjct: 249 QRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNLSH 308
Query: 184 NHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME 243
N L P +S+L LNLS N LP++I + L+ L + N L T+P EL ++
Sbjct: 309 NKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQ 368
Query: 244 SLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLK 302
L L + N +PE + ++L + + N +E+L L +N I +DLR N LK
Sbjct: 369 QLSSLGISFNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNRMNHIKHVDLRMNHLK 428
Query: 303 S-VPDEIILLRSLERLDLSNN-----DISSLPYSLGNLH-----LKFLALEGNPLRTIRR 351
+ V + + + + +DL +N D+SSL SL LH L+ L L G LRT+
Sbjct: 429 TMVIENLEGNKHITHVDLRDNRLTDLDLSSL-CSLEQLHCGRNQLRELTLSGFSLRTLY- 486
Query: 352 EIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITL-KILDYSDKQ 410
A+ +T VN++ + +L LD S
Sbjct: 487 ----------------------------ASSNRLTA-----VNVYPVPSLLTFLDLSRNL 513
Query: 411 ATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCV 470
+PD +A K + ++ S N L E+P R++ + + L N + + L
Sbjct: 514 LECVPDWACEAKKIEV---LDVSYNLLTEVPVRILSSLSL-RKLMLGHNHVQNLPT-LVE 568
Query: 471 LQKLTFLDLRNNFLNSLPEEMES-LVRLQTINLSFNRFKMLPE----------------- 512
L LDL++N L LP+ + S + L+ +N S N + LP
Sbjct: 569 HIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLT 628
Query: 513 ----------VLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELG 562
VL L + ++NNQ+ + K+ +E L L+L N L IP +
Sbjct: 629 NNLLTDQCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIA 688
Query: 563 NCVNLRTLLLDGN 575
NC L TL+ N
Sbjct: 689 NCKRLHTLVAHSN 701
Score = 62.4 bits (150), Expect = 1e-09
Identities = 45/135 (33%), Positives = 72/135 (53%), Gaps = 5/135 (3%)
Query: 447 LKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLN-SLPEEMESLVR---LQTINL 502
+ + +S VDLS L + L Q +T+L+LR+NF+ P +++L + L+ +NL
Sbjct: 247 VSQRISTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKFSQLKGLNL 306
Query: 503 SFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELG 562
S N+ + P +L I TL + +S N + P ++ + NL TL L N L +P ELG
Sbjct: 307 SHNKLGLFPILLCEISTLTELNLSCNGFHDL-PSQIGNLLNLQTLCLDGNFLTTLPEELG 365
Query: 563 NCVNLRTLLLDGNPF 577
N L +L + N F
Sbjct: 366 NLQQLSSLGISFNNF 380
>gi|37221175 PH domain and leucine rich repeat protein phosphatase
[Homo sapiens]
Length = 1205
Score = 128 bits (322), Expect = 1e-29
Identities = 133/484 (27%), Positives = 227/484 (46%), Gaps = 55/484 (11%)
Query: 128 ENLQKLNVSHNKLKILP------EEITNLRNLKCLYLQHNELTCISEGFEQL---SNLED 178
+ + +++S L+ LP +++T+L NLK +L+ N + G +L + L+
Sbjct: 125 QRISSVDLSCCSLEHLPANLFYSQDLTHL-NLKQNFLRQNPSLPAARGLNELQRFTKLKS 183
Query: 179 LDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPE 238
L+LSNNHL P + S+ +L LN+S N L+S+PA + M L+ + N L+++P E
Sbjct: 184 LNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQSLPAE 243
Query: 239 LAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLR 297
L M+ L L L N+ +PE + + +L + N +E L + L+ + I +DLR
Sbjct: 244 LENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIKHVDLR 303
Query: 298 DNKL-KSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTI------- 349
N + K + DE+ L+ + +LDL +N + L + N +++ L E N L T+
Sbjct: 304 LNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMIFN-NIEVLHCERNQLVTLDICGYFL 362
Query: 350 ------RREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKI 403
E++ V YL D ++ E+ E ESR L++
Sbjct: 363 KALYASSNELVQLDVYPVPNYL--SYMDVSRNRLENVPEWV----CESR-------KLEV 409
Query: 404 LDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSF 463
LD Q +P +F ++ + + NQL +P+R+ + V +D+ N+L
Sbjct: 410 LDIGHNQICELPARLF---CNSSLRKLLAGHNQLARLPERLE--RTSVEVLDVQHNQLLE 464
Query: 464 ISLELCV-LQKLTFLDLRNNFLNSLP-----EEMESLVRLQTINLSFNRF--KMLPEVLY 515
+ L + L FL+ N L SLP EE S+ LQ + L+ N K +P +L
Sbjct: 465 LPPNLLMKADSLRFLNASANKLESLPPATLSEETNSI--LQELYLTNNSLTDKCVP-LLT 521
Query: 516 RIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
L+ + ++ N++ S KM +E L +DL N L IP + NC + T++ N
Sbjct: 522 GHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRRMHTVIAHSN 581
Query: 576 PFRV 579
V
Sbjct: 582 CIEV 585
Score = 122 bits (307), Expect = 7e-28
Identities = 119/479 (24%), Positives = 228/479 (47%), Gaps = 33/479 (6%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
T L L +SNN L + +P L L++ N L S+P+A+ + NLQ + N L+
Sbjct: 179 TKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLDGNFLQ 238
Query: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVP-ASFSSLSSLV 200
LP E+ N++ L L L NE T I E E+L+ ++ L +S N + T+ + + +
Sbjct: 239 SLPAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALRKMPHIK 298
Query: 201 RLNLSSNELKSLPA-EINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
++L N ++ L A E++ ++ + LD N L + + ++E+L+ RN+L L
Sbjct: 299 HVDLRLNVIRKLIADEVDFLQHVTQLDLRDNKLGDLDAMI--FNNIEVLHCERNQLVTL- 355
Query: 260 EFPSCS-LLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLD 318
C LK L+ N++ L+ + N + +D+ N+L++VP+ + R LE LD
Sbjct: 356 --DICGYFLKALYASSNELVQLDVYPVP--NYLSYMDVSRNRLENVPEWVCESRKLEVLD 411
Query: 319 LSNNDISSLPYSL-GNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQS 377
+ +N I LP L N L+ L N L + E + + + EVL +++ + P+
Sbjct: 412 IGHNQICELPARLFCNSSLRKLLAGHNQLARL-PERLERTSVEVLDVQHNQLLELPPNLL 470
Query: 378 ESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQL 437
A +L+ L+ S + +P ++I+ + + N L
Sbjct: 471 MKAD------------------SLRFLNASANKLESLPPATLSEETNSILQELYLTNNSL 512
Query: 438 CEIPKRMVELKEMVSDVDLSFNKL-SFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496
+ ++ + + +++N+L SF + ++ L++L +DL N L ++P + + R
Sbjct: 513 TDKCVPLLTGHPHLKILHMAYNRLQSFPASKMAKLEELEEIDLSGNKLKAIPTTIMNCRR 572
Query: 497 LQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLL 555
+ T+ N ++ PEV+ ++ ++ + +S N++ V + + L LDL N L
Sbjct: 573 MHTVIAHSNCIEVFPEVM-QLPEIKCVDLSCNELSEVTLPE-NLPPKLQELDLTGNPRL 629
Score = 50.8 bits (120), Expect = 3e-06
Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 1/121 (0%)
Query: 467 ELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILIS 526
EL KL L+L NN L P + S+ L +N+S N + +P + + L+T L+
Sbjct: 174 ELQRFTKLKSLNLSNNHLGDFPLAVCSIPTLAELNVSCNALRSVPAAVGVMHNLQTFLLD 233
Query: 527 NNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRVPRAAILM 586
N + S+ P +++ M+ L+ L L N+ IP L + L + GN R L
Sbjct: 234 GNFLQSL-PAELENMKQLSYLGLSFNEFTDIPEVLEKLTAVDKLCMSGNCVETLRLQALR 292
Query: 587 K 587
K
Sbjct: 293 K 293
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 117 bits (292), Expect = 4e-26
Identities = 105/391 (26%), Positives = 187/391 (47%), Gaps = 31/391 (7%)
Query: 179 LDLSNNHLTT--VPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIP 236
+DLS N P + +++SL L L+ L LP E+ +++L+HL + N L T+
Sbjct: 13 VDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLH 72
Query: 237 PELAGMESLELLYLRRNKLR---FLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
EL+ + SL + R N L+ + L L + NQ+ E L++ ++LV
Sbjct: 73 GELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRE-LENAKNMLV 131
Query: 294 LDLRDNKLKSVPDEIIL-LRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRR 351
L+L N + ++P+++ + L L LDLS N + SLP + L HL+ L L GNPL +
Sbjct: 132 LNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQL 191
Query: 352 EIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQA 411
+ T +LRS T LP+ ++ + L +D S
Sbjct: 192 RQLPAMTALQTLHLRS------------TQRTQSNLPT----SLEGLSNLADVDLSCNDL 235
Query: 412 TLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVL 471
T +P+ ++ + +N S NQ+ E+ ++ V ++LS N+L+ + +C L
Sbjct: 236 TRVPECLYTLPS---LRRLNLSSNQITEL-SLCIDQWVHVETLNLSRNQLTSLPSAICKL 291
Query: 472 QKLTFLDLRNNFLN--SLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQ 529
KL L L +N L+ LP + L L+ + N +++PE L R L ++++ N
Sbjct: 292 SKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNH 351
Query: 530 VGSVDPQKMKMMENLTTLDLQNNDLLQIPPE 560
+ ++ P+ + + + LD++ N L +PP+
Sbjct: 352 LVTL-PEAIHFLTEIEVLDVRENPNLVMPPK 381
Score = 115 bits (288), Expect = 1e-25
Identities = 96/359 (26%), Positives = 178/359 (49%), Gaps = 27/359 (7%)
Query: 99 DDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYL 158
++++ + +L L ++ L LP + L+ L+ L+VSHN L L E+++L +L+ +
Sbjct: 27 ENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVA 86
Query: 159 QHNEL--TCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEI 216
+ N L + + + +L +L LDLS+N LT P + +++ LNLS N + ++P ++
Sbjct: 87 RANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 146
Query: 217 -NRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRF--LPEFPSCSLLKELHVG 273
+ L +LD + N LE++PP++ + L+ L L N L L + P+ + L+ LH+
Sbjct: 147 FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLR 206
Query: 274 ENQ-IEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLG 332
Q + L+ L+++ +DL N L VP+ + L SL RL+LS+N I+ L +
Sbjct: 207 STQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCID 266
Query: 333 N-LHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSES 391
+H++ L L N L ++ I + L +K+ DG LPS
Sbjct: 267 QWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDG-------------LPS-- 311
Query: 392 RVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEM 450
I + L+ ++ L+P+ + K + + +KN L +P+ + L E+
Sbjct: 312 --GIGKLTNLEEFMAANNNLELVPESLCRCPK---LRKLVLNKNHLVTLPEAIHFLTEI 365
Score = 104 bits (259), Expect = 3e-22
Identities = 82/249 (32%), Positives = 131/249 (52%), Gaps = 8/249 (3%)
Query: 87 LIISNNKLQSLTDDLRL-LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILP- 144
L +S+N + ++ + L + L L LD+ +N+L SLP +R L +LQ L ++ N L
Sbjct: 132 LNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQL 191
Query: 145 EEITNLRNLKCLYLQHNELTC--ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
++ + L+ L+L+ + T + E LSNL D+DLS N LT VP +L SL RL
Sbjct: 192 RQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRL 251
Query: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRF--LPE 260
NLSSN++ L I++ ++ L+ + N L ++P + + L+ LYL NKL F LP
Sbjct: 252 NLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPS 311
Query: 261 -FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDL 319
+ L+E N +E++ E L + L L N L ++P+ I L +E LD+
Sbjct: 312 GIGKLTNLEEFMAANNNLELV-PESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDV 370
Query: 320 SNNDISSLP 328
N +P
Sbjct: 371 RENPNLVMP 379
Score = 101 bits (251), Expect = 2e-21
Identities = 85/264 (32%), Positives = 135/264 (51%), Gaps = 18/264 (6%)
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQL--TSLPSAIRELENLQKLNVSHNKLK 141
L L +S+N L +L +L LP+L + N L + +P I +L++L L++SHN+L
Sbjct: 58 LEHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLT 117
Query: 142 ILPEEITNLRNLKCLYLQHNELTCI-SEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
P E+ N +N+ L L HN + I ++ F L++L LDLS N L ++P L L
Sbjct: 118 ECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQ 177
Query: 201 RLNLSSN-----ELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKL 255
L L+ N +L+ LPA + ++ L HL +P L G+ +L + L N L
Sbjct: 178 TLVLNGNPLLHAQLRQLPA-MTALQTL-HLRSTQRTQSNLPTSLEGLSNLADVDLSCNDL 235
Query: 256 RFLPE-FPSCSLLKELHVGENQIEMLE--AEHLKHLNSILVLDLRDNKLKSVPDEIILLR 312
+PE + L+ L++ NQI L + H+ + L+L N+L S+P I L
Sbjct: 236 TRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVET---LNLSRNQLTSLPSAICKLS 292
Query: 313 SLERLDLSNN--DISSLPYSLGNL 334
L++L L++N D LP +G L
Sbjct: 293 KLKKLYLNSNKLDFDGLPSGIGKL 316
Score = 86.7 bits (213), Expect = 6e-17
Identities = 60/186 (32%), Positives = 97/186 (52%), Gaps = 4/186 (2%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
++L + +S N L + + L LP+L L++ NQ+T L I + +++ LN+S N+L
Sbjct: 223 SNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLT 282
Query: 142 ILPEEITNLRNLKCLYLQHNELTC--ISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199
LP I L LK LYL N+L + G +L+NLE+ +NN+L VP S L
Sbjct: 283 SLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKL 342
Query: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELA--GMESLELLYLRRNKLRF 257
+L L+ N L +LP I+ + ++ LD N +PP+ A E + + +N+LR
Sbjct: 343 RKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPPKPADRAAEWYNIDFSLQNQLRL 402
Query: 258 LPEFPS 263
P+
Sbjct: 403 AGASPA 408
Score = 67.0 bits (162), Expect = 5e-11
Identities = 41/149 (27%), Positives = 79/149 (53%), Gaps = 3/149 (2%)
Query: 430 INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS--L 487
+ ++ LC +P+ + L+++ + +S N L+ + EL L L + R N L + +
Sbjct: 38 LKLNRTGLCYLPEELAALQKL-EHLSVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGV 96
Query: 488 PEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTL 547
P+++ L L ++LS N+ P L + + +S+N + ++ Q + +L L
Sbjct: 97 PDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYL 156
Query: 548 DLQNNDLLQIPPELGNCVNLRTLLLDGNP 576
DL N L +PP++ V+L+TL+L+GNP
Sbjct: 157 DLSENRLESLPPQMRRLVHLQTLVLNGNP 185
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 112 bits (279), Expect = 1e-24
Identities = 138/477 (28%), Positives = 211/477 (44%), Gaps = 48/477 (10%)
Query: 43 LSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQT-----DLTKLIISNNKLQSL 97
L G NLS VP ++ ++ NL G Q +L L + N+L+SL
Sbjct: 119 LDGNNLSSVPPAAFQ---NLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSL 175
Query: 98 T-DDLRLLPALTVLDIHDNQLTSLPSAIRE-LENLQKLNVSHNKLKILPEE-ITNLRNLK 154
PAL L + +N+L+ L + E L +L LN+ N L +LP+ L +L+
Sbjct: 176 ALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLR 235
Query: 155 CLYLQHNELTCISEG-FEQLSNLEDLDLSNNHLTTVPAS-FSSLSSLVRLNLSSNELKSL 212
L L N L + F L+ L +LDLS N L + A+ F L L +L L N + ++
Sbjct: 236 ELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAV 295
Query: 213 -PAEINRMKRLKHLDCNSN----LLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSL 266
P +K L+ LD + N LLE P L G+ L L + LR P F
Sbjct: 296 APGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR--PRTFKDLHF 353
Query: 267 LKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL-LRSLERLDLSNNDIS 325
L+EL +G N+I L + L + VL L N+L+ V L L ++ ++LS N +
Sbjct: 354 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR 413
Query: 326 SLP----YSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESAT 381
+LP LG LH L LEG+ L IR + + R +KD+G
Sbjct: 414 NLPEQVFRGLGKLH--SLHLEGSCLGRIRPHTFT----GLSGLRRLFLKDNG-------- 459
Query: 382 ETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIP 441
L ++ + L LD + Q T +P +F + + + S+N+L E+P
Sbjct: 460 -----LVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK--LEYLLLSRNRLAELP 512
Query: 442 KRMVELKEMVSDVDLSFNKLSFISLELCV-LQKLTFLDLRNNFLNSLPEEMESLVRL 497
+ + +D+S N+L + L L +L +L LRNN L + + L RL
Sbjct: 513 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERL 569
Score = 98.6 bits (244), Expect = 1e-20
Identities = 144/517 (27%), Positives = 229/517 (44%), Gaps = 48/517 (9%)
Query: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALT-VLDIHDNQLTSLP-SAIRELENLQKLNVSH 137
+ D + S+ L L D + P T L + N L+S+P +A + L +L LN+
Sbjct: 89 DDADELSVFCSSRNLTRLPDGV---PGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQG 145
Query: 138 NKLKIL-PEEITNLRNLKCLYLQHNELTCISEG-FEQLSNLEDLDLSNNHLTTVPAS-FS 194
+L L P+ + L NL L+L+ N+L ++ G F L L LSNN L+ + F
Sbjct: 146 GQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFE 205
Query: 195 SLSSLVRLNLSSNELKSLP-AEINRMKRLKHLDCNSNLLETIPPEL-AGMESLELLYLRR 252
L SL LNL N L LP A + L+ L N L + P L +G+ L L L R
Sbjct: 206 GLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSR 265
Query: 253 NKLRFLPE--FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL 310
N LR + F L++L++ N I + L ++ LDL N++ + ++
Sbjct: 266 NALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFP 325
Query: 311 -LRSLERLDLSNNDISSL-PYSLGNLH-LKFLALEGNPLRTI-RREIISKGTQEVLKYLR 366
L L L LS+N I+SL P + +LH L+ L L N +R + R G EVL
Sbjct: 326 GLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDH 385
Query: 367 SKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNI 426
+++++ T A +++ S +P++VF +
Sbjct: 386 NQLQEVKAGAFLGLTNVA------------------VMNLSGNCLRNLPEQVFRGLGK-- 425
Query: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLE-LCVLQKLTFLDLRNNFLN 485
+ S++ + L I + + L N L I + L L +L LDL +N L
Sbjct: 426 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 485
Query: 486 SLPEEM-ESLVRLQTINLSFNRFKMLPE----VLYRIFTLETILISNNQVGSVDPQKMKM 540
LP + + L +L+ + LS NR LP L R F L+ +S+N++ ++ +
Sbjct: 486 HLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLD---VSHNRLEALPNSLLAP 542
Query: 541 MENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPF 577
+ L L L+NN L P+ L L L+GNP+
Sbjct: 543 LGRLRYLSLRNNSLRTFTPQ---PPGLERLWLEGNPW 576
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 112 bits (279), Expect = 1e-24
Identities = 138/477 (28%), Positives = 211/477 (44%), Gaps = 48/477 (10%)
Query: 43 LSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQT-----DLTKLIISNNKLQSL 97
L G NLS VP ++ ++ NL G Q +L L + N+L+SL
Sbjct: 81 LDGNNLSSVPPAAFQ---NLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSL 137
Query: 98 T-DDLRLLPALTVLDIHDNQLTSLPSAIRE-LENLQKLNVSHNKLKILPEE-ITNLRNLK 154
PAL L + +N+L+ L + E L +L LN+ N L +LP+ L +L+
Sbjct: 138 ALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLR 197
Query: 155 CLYLQHNELTCISEG-FEQLSNLEDLDLSNNHLTTVPAS-FSSLSSLVRLNLSSNELKSL 212
L L N L + F L+ L +LDLS N L + A+ F L L +L L N + ++
Sbjct: 198 ELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAV 257
Query: 213 -PAEINRMKRLKHLDCNSN----LLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSL 266
P +K L+ LD + N LLE P L G+ L L + LR P F
Sbjct: 258 APGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR--PRTFKDLHF 315
Query: 267 LKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL-LRSLERLDLSNNDIS 325
L+EL +G N+I L + L + VL L N+L+ V L L ++ ++LS N +
Sbjct: 316 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR 375
Query: 326 SLP----YSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESAT 381
+LP LG LH L LEG+ L IR + + R +KD+G
Sbjct: 376 NLPEQVFRGLGKLH--SLHLEGSCLGRIRPHTFT----GLSGLRRLFLKDNG-------- 421
Query: 382 ETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIP 441
L ++ + L LD + Q T +P +F + + + S+N+L E+P
Sbjct: 422 -----LVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK--LEYLLLSRNRLAELP 474
Query: 442 KRMVELKEMVSDVDLSFNKLSFISLELCV-LQKLTFLDLRNNFLNSLPEEMESLVRL 497
+ + +D+S N+L + L L +L +L LRNN L + + L RL
Sbjct: 475 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERL 531
Score = 98.6 bits (244), Expect = 1e-20
Identities = 144/517 (27%), Positives = 229/517 (44%), Gaps = 48/517 (9%)
Query: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALT-VLDIHDNQLTSLP-SAIRELENLQKLNVSH 137
+ D + S+ L L D + P T L + N L+S+P +A + L +L LN+
Sbjct: 51 DDADELSVFCSSRNLTRLPDGV---PGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQG 107
Query: 138 NKLKIL-PEEITNLRNLKCLYLQHNELTCISEG-FEQLSNLEDLDLSNNHLTTVPAS-FS 194
+L L P+ + L NL L+L+ N+L ++ G F L L LSNN L+ + F
Sbjct: 108 GQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFE 167
Query: 195 SLSSLVRLNLSSNELKSLP-AEINRMKRLKHLDCNSNLLETIPPEL-AGMESLELLYLRR 252
L SL LNL N L LP A + L+ L N L + P L +G+ L L L R
Sbjct: 168 GLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSR 227
Query: 253 NKLRFLPE--FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL 310
N LR + F L++L++ N I + L ++ LDL N++ + ++
Sbjct: 228 NALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFP 287
Query: 311 -LRSLERLDLSNNDISSL-PYSLGNLH-LKFLALEGNPLRTI-RREIISKGTQEVLKYLR 366
L L L LS+N I+SL P + +LH L+ L L N +R + R G EVL
Sbjct: 288 GLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDH 347
Query: 367 SKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNI 426
+++++ T A +++ S +P++VF +
Sbjct: 348 NQLQEVKAGAFLGLTNVA------------------VMNLSGNCLRNLPEQVFRGLGK-- 387
Query: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLE-LCVLQKLTFLDLRNNFLN 485
+ S++ + L I + + L N L I + L L +L LDL +N L
Sbjct: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447
Query: 486 SLPEEM-ESLVRLQTINLSFNRFKMLPE----VLYRIFTLETILISNNQVGSVDPQKMKM 540
LP + + L +L+ + LS NR LP L R F L+ +S+N++ ++ +
Sbjct: 448 HLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLD---VSHNRLEALPNSLLAP 504
Query: 541 MENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPF 577
+ L L L+NN L P+ L L L+GNP+
Sbjct: 505 LGRLRYLSLRNNSLRTFTPQ---PPGLERLWLEGNPW 538
>gi|193788651 leucine rich repeat containing 69 [Homo sapiens]
Length = 347
Score = 112 bits (279), Expect = 1e-24
Identities = 78/254 (30%), Positives = 132/254 (51%), Gaps = 25/254 (9%)
Query: 109 VLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISE 168
++ ++ ++T +PSA+ +L L+ L + +N + + E+ NL L L L +N L + E
Sbjct: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
Query: 169 GFEQLSNLEDLDLSNNHLTT-VPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDC 227
+ L++L++L LS N + P + L +L+ LNL++N L LP E++R+K L ++
Sbjct: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137
Query: 228 NSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKH 287
N N L +IP EL +E+L L L N+L +PE E + LK
Sbjct: 138 NYNQLASIPRELCFLENLVELQLNYNQLICIPE--------------------EIKFLKK 177
Query: 288 LNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLR 347
L +L L N + +P+E+ L+ L LD++ N I P +L L+ EGNPL
Sbjct: 178 LQKLL---LARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLREFYCEGNPL- 233
Query: 348 TIRREIISKGTQEV 361
+++ +IS + V
Sbjct: 234 FLQQPVISTQQENV 247
Score = 92.4 bits (228), Expect = 1e-18
Identities = 59/217 (27%), Positives = 111/217 (51%), Gaps = 4/217 (1%)
Query: 32 LKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDLTKLIISN 91
L + + + L+G+ ++++P + ++ NL T LT L + N
Sbjct: 10 LSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGN 69
Query: 92 NKLQSLTDDLRLLPALTVLDIHDNQLTSL-PSAIRELENLQKLNVSHNKLKILPEEITNL 150
N L+ + ++++ L +L L + N++ P A L+NL LN+++N L LP+E++ L
Sbjct: 70 NLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRL 129
Query: 151 RNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELK 210
++L + + +N+L I L NL +L L+ N L +P L L +L L+ N +
Sbjct: 130 KSLTYMSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARNNIG 189
Query: 211 SLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLEL 247
LP E+ +K+L+ LD N+++ P +G + L+L
Sbjct: 190 VLPEELCDLKKLRILDIAGNIIQIFP---SGFQDLKL 223
Score = 89.4 bits (220), Expect = 9e-18
Identities = 55/195 (28%), Positives = 102/195 (52%), Gaps = 1/195 (0%)
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKL-KI 142
L L++ NN + + +L L LT L++ +N L +P ++ L +L+ L++S N++ +
Sbjct: 39 LKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRF 98
Query: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
P L+NL L L +N LT + + +L +L + ++ N L ++P L +LV L
Sbjct: 99 APGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSINYNQLASIPRELCFLENLVEL 158
Query: 203 NLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFP 262
L+ N+L +P EI +K+L+ L N + +P EL ++ L +L + N ++ P
Sbjct: 159 QLNYNQLICIPEEIKFLKKLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGF 218
Query: 263 SCSLLKELHVGENQI 277
L+E + N +
Sbjct: 219 QDLKLREFYCEGNPL 233
Score = 85.1 bits (209), Expect = 2e-16
Identities = 63/207 (30%), Positives = 107/207 (51%), Gaps = 4/207 (1%)
Query: 141 KILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
++L + ++ +N K + L ++T + +L L+ L L NN + V +L+ L
Sbjct: 4 RLLIKALSGGKNTKIITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLT 63
Query: 201 RLNLSSNELKSLPAEINRMKRLKHLDCNSN-LLETIPPELAGMESLELLYLRRNKLRFLP 259
LNL +N L+ +P E+ + LK+L + N + P G+++L LL L N L LP
Sbjct: 64 TLNLGNNLLEEVPEEMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLP 123
Query: 260 -EFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLD 318
E L + + NQ+ + E L L +++ L L N+L +P+EI L+ L++L
Sbjct: 124 QEVSRLKSLTYMSINYNQLASIPRE-LCFLENLVELQLNYNQLICIPEEIKFLKKLQKLL 182
Query: 319 LSNNDISSLPYSLGNL-HLKFLALEGN 344
L+ N+I LP L +L L+ L + GN
Sbjct: 183 LARNNIGVLPEELCDLKKLRILDIAGN 209
Score = 65.5 bits (158), Expect = 1e-10
Identities = 51/170 (30%), Positives = 84/170 (49%), Gaps = 26/170 (15%)
Query: 430 INFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPE 489
I + ++ ++P + +L + + V L N + + ELC L +LT L+L NN L +PE
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLV-LQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPE 77
Query: 490 EMESLVRLQTINLSFNRF------------------------KMLPEVLYRIFTLETILI 525
EM+ L L+ ++LS NR LP+ + R+ +L + I
Sbjct: 78 EMKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSI 137
Query: 526 SNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
+ NQ+ S+ P+++ +ENL L L N L+ IP E+ L+ LLL N
Sbjct: 138 NYNQLASI-PRELCFLENLVELQLNYNQLICIPEEIKFLKKLQKLLLARN 186
Score = 63.5 bits (153), Expect = 5e-10
Identities = 59/229 (25%), Positives = 109/229 (47%), Gaps = 25/229 (10%)
Query: 317 LDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPS 375
+ L+ ++ +P +LG L LK L L+ N + + E+ + TQ L + + ++ P
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNL-TQLTTLNLGNNLLEEVPE 77
Query: 376 QSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKN 435
+ + T +LK L S + D +++ I+ +N + N
Sbjct: 78 EMKYLT------------------SLKNLHLSGNRICRFAPGACDGLQNLIL--LNLNNN 117
Query: 436 QLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLV 495
L ++P+ + LK + + +++N+L+ I ELC L+ L L L N L +PEE++ L
Sbjct: 118 HLTQLPQEVSRLKSLTY-MSINYNQLASIPRELCFLENLVELQLNYNQLICIPEEIKFLK 176
Query: 496 RLQTINLSFNRFKMLPEVLYRIFTLETILISNN--QVGSVDPQKMKMME 542
+LQ + L+ N +LPE L + L + I+ N Q+ Q +K+ E
Sbjct: 177 KLQKLLLARNNIGVLPEELCDLKKLRILDIAGNIIQIFPSGFQDLKLRE 225
Score = 55.8 bits (133), Expect = 1e-07
Identities = 36/129 (27%), Positives = 68/129 (52%), Gaps = 1/129 (0%)
Query: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEV 513
+ L+ K++ + L L L L L+NN + + E+ +L +L T+NL N + +PE
Sbjct: 19 ITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNNLLEEVPEE 78
Query: 514 LYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLD 573
+ + +L+ + +S N++ P ++NL L+L NN L Q+P E+ +L + ++
Sbjct: 79 MKYLTSLKNLHLSGNRICRFAPGACDGLQNLILLNLNNNHLTQLPQEVSRLKSLTYMSIN 138
Query: 574 GNPF-RVPR 581
N +PR
Sbjct: 139 YNQLASIPR 147
Score = 31.2 bits (69), Expect = 2.9
Identities = 19/53 (35%), Positives = 27/53 (50%)
Query: 523 ILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
I+ N + + P + + L TL LQNN + ++ PEL N L TL L N
Sbjct: 18 IITLNGKKMTKMPSALGKLPGLKTLVLQNNLIPKVCPELCNLTQLTTLNLGNN 70
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 109 bits (273), Expect = 6e-24
Identities = 119/457 (26%), Positives = 208/457 (45%), Gaps = 59/457 (12%)
Query: 110 LDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEG 169
+D D L+ LPS + + L+++ N ++LP + +LR L+ L L N LT I +G
Sbjct: 50 VDCSDLGLSELPSNLSVFTSYLDLSMN-NISQLLPNPLPSLRFLEELRLAGNALTYIPKG 108
Query: 170 -FEQLSNLEDLDLSNNHLTTVPA-SFSSLSSLVRLNLSSNELKSLPAE-INRMKRLKHLD 226
F L +L+ L L NN L VP + +L SL L L +N + +P + + L+HL
Sbjct: 109 AFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLW 168
Query: 227 CNSNLLETIPPE-LAGMESLELLYLRRNKLRFLPE--FPSCSLLKELHVGENQIEMLEAE 283
+ N L IP + + +L+ + L NK+ +P+ F + S L LH+ N+I L +
Sbjct: 169 LDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKK 228
Query: 284 HLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYS--LGNLHLKFLAL 341
L+S+ LDL N L P I L +L+ L +N+I S+P +GN L +
Sbjct: 229 CFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHF 288
Query: 342 EGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITL 401
NP+ + + + + L LR+ +TL S++
Sbjct: 289 YDNPI-----QFVGRSAFQHLPELRT-----------------LTLNGASQIT------- 319
Query: 402 KILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKL 461
E D + + S+ + Q+ +P+ + + +DLS+N L
Sbjct: 320 ---------------EFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLL 364
Query: 462 SFISLELCVLQKLTFLDLRNNFLNSLP-EEMESLVRLQTINLSFNRFKML-PEVLYRIFT 519
+ V QKL +DLR+N + + + + L+ L+++NL++N+ ++ P + +
Sbjct: 365 EDLP-SFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPS 423
Query: 520 LETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQ 556
L + +S+N + S + + LT L L N LQ
Sbjct: 424 LIKLDLSSNLLSSF---PITGLHGLTHLKLTGNHALQ 457
Score = 86.7 bits (213), Expect = 6e-17
Identities = 83/289 (28%), Positives = 133/289 (46%), Gaps = 42/289 (14%)
Query: 62 IPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDD-LRLLPALTVLDIHDNQLTSL 120
IP+ A NLS L L + NN++ SL L +L LD++ N L
Sbjct: 201 IPDYAFGNLS-----------SLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
Query: 121 PSAIRELENLQKLNVSHNKLKILPEE-ITNLRNLKCLYLQHNELTCIS-EGFEQLSNLED 178
P+AIR L NL++L N ++ +PE+ +L ++ N + + F+ L L
Sbjct: 250 PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 179 LDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEI-NRMKRLKHLDCNSNLLETIPP 237
L L+ T + ++L L L+ ++ SLP + N++ L+ LD + NLLE
Sbjct: 310 LTLNGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLED--- 366
Query: 238 ELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLR 297
LP F C L+++ + N+I ++ + + L S+ L+L
Sbjct: 367 --------------------LPSFSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLA 406
Query: 298 DNKLKSV-PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGN 344
NK+ + P+ L SL +LDLS+N +SS P + LH L L L GN
Sbjct: 407 WNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFP--ITGLHGLTHLKLTGN 453
Score = 55.1 bits (131), Expect = 2e-07
Identities = 48/189 (25%), Positives = 85/189 (44%), Gaps = 6/189 (3%)
Query: 401 LKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNK 460
L+ L + T IP F + S V + NQL +P ++ + + L N
Sbjct: 92 LEELRLAGNALTYIPKGAFTGLYSLKVLMLQ--NNQLRHVPTEALQNLRSLQSLRLDANH 149
Query: 461 LSFISLE-LCVLQKLTFLDLRNNFLNSLP-EEMESLVRLQTINLSFNRFKMLPEVLY-RI 517
+S++ L L L L +N L +P + SL LQ + L+ N+ +P+ + +
Sbjct: 150 ISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNL 209
Query: 518 FTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPF 577
+L + + NN++ S+ + + +L TLDL N+L + P + NL+ L N
Sbjct: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNI 269
Query: 578 R-VPRAAIL 585
R +P A +
Sbjct: 270 RSIPEKAFV 278
Score = 48.9 bits (115), Expect = 1e-05
Identities = 38/129 (29%), Positives = 66/129 (51%), Gaps = 5/129 (3%)
Query: 450 MVSDVDLSFNKLSFISLELCVLQKLTFLDLR-NNFLNSLPEEMESLVRLQTINLSFNRFK 508
M+ VD S LS + L V ++LDL NN LP + SL L+ + L+ N
Sbjct: 46 MLLRVDCSDLGLSELPSNLSVFT--SYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALT 103
Query: 509 MLPEVLYR-IFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPE-LGNCVN 566
+P+ + +++L+ +++ NNQ+ V + ++ + +L +L L N + +PP +
Sbjct: 104 YIPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHS 163
Query: 567 LRTLLLDGN 575
LR L LD N
Sbjct: 164 LRHLWLDDN 172
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 108 bits (270), Expect = 1e-23
Identities = 68/166 (40%), Positives = 94/166 (56%)
Query: 94 LQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNL 153
L +L L L L LD+ N L +LP+ + ++ L L +SHN L LPE + L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 154 KCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLP 213
L + HN L + LS L+ LDLS N L T+P L SL+ LNL+SN L+SLP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 214 AEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
A + ++ L+ L +SNLL ++P +LA + L L LR N+LR LP
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 87.0 bits (214), Expect = 4e-17
Identities = 65/197 (32%), Positives = 103/197 (52%), Gaps = 3/197 (1%)
Query: 186 LTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245
LT +PA S L+ L L+LS N L++LPA + +M+ L L + N L +P L + +L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 246 ELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
L + N+L+ LP + S L+ L + +N ++ L E + L S+L L+L N+L+S+
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQSL 232
Query: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363
P + LRSL L L +N ++S+P L L L L L N LR + E++ +
Sbjct: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQG 292
Query: 364 YLRSKIKDDGPSQSESA 380
+ D PS +A
Sbjct: 293 NPLGEASPDAPSSPVAA 309
Score = 78.2 bits (191), Expect = 2e-14
Identities = 70/195 (35%), Positives = 98/195 (50%), Gaps = 12/195 (6%)
Query: 170 FEQLSNLEDLDLSNNHLTTVPASFSSLSSLV------RLNLSS---NELKSLPAEINRMK 220
F +LS ED L L +P S S L SLV R L + L +LPA ++ +
Sbjct: 66 FLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLA 125
Query: 221 RLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEM 279
L HLD + N LET+P + M L L L N L LPE + L L V N+++
Sbjct: 126 HLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT 185
Query: 280 LEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKF 338
L L L+++ LDL N L ++P EI L SL L+L++N + SLP SL L L+
Sbjct: 186 LPPA-LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
Query: 339 LALEGNPLRTIRREI 353
L L N L ++ ++
Sbjct: 245 LVLHSNLLASVPADL 259
Score = 69.7 bits (169), Expect = 7e-12
Identities = 49/144 (34%), Positives = 78/144 (54%), Gaps = 5/144 (3%)
Query: 433 SKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEME 492
S N L E+P+ + L + + ++ N+L + L L L LDL N L++LP E+
Sbjct: 156 SHNCLSELPEALGALPALTF-LTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 214
Query: 493 SLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNN 552
L L +NL+ NR + LP L + +L +++ +N + SV P + + LT LDL++N
Sbjct: 215 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASV-PADLARLPLLTRLDLRDN 273
Query: 553 DLLQIPPELGNCVNLRTLLLDGNP 576
L +PPEL + +R L GNP
Sbjct: 274 QLRDLPPELLDAPFVR---LQGNP 294
Score = 60.8 bits (146), Expect = 3e-09
Identities = 43/127 (33%), Positives = 71/127 (55%), Gaps = 5/127 (3%)
Query: 451 VSDVDLSFNKLSFISLELCVLQK--LTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFK 508
++ +DLSFN L +L CVLQ L L L +N L+ LPE + +L L + ++ NR +
Sbjct: 127 LAHLDLSFNSLE--TLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 509 MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLR 568
LP L + TL+ + +S N + ++ P+ + + +L L+L +N L +P L +LR
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 569 TLLLDGN 575
L+L N
Sbjct: 244 LLVLHSN 250
Score = 47.0 bits (110), Expect = 5e-05
Identities = 29/92 (31%), Positives = 49/92 (53%), Gaps = 1/92 (1%)
Query: 484 LNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMEN 543
L +LP + L L ++LSFN + LP + ++ L +L+S+N + + P+ + +
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSEL-PEALGALPA 172
Query: 544 LTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
LT L + +N L +PP LG L+ L L N
Sbjct: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQN 204
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/105 (32%), Positives = 52/105 (49%), Gaps = 1/105 (0%)
Query: 471 LQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530
L L LDL N L +LP + + L + LS N LPE L + L + +++N++
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
++ P + + L LDL N L +PPE+G +L L L N
Sbjct: 184 QTL-PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
>gi|61742784 leucine rich repeat and death domain containing protein
isoform 1 [Homo sapiens]
Length = 910
Score = 108 bits (270), Expect = 1e-23
Identities = 68/166 (40%), Positives = 94/166 (56%)
Query: 94 LQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNL 153
L +L L L L LD+ N L +LP+ + ++ L L +SHN L LPE + L L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 154 KCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLP 213
L + HN L + LS L+ LDLS N L T+P L SL+ LNL+SN L+SLP
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 214 AEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
A + ++ L+ L +SNLL ++P +LA + L L LR N+LR LP
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLP 279
Score = 87.0 bits (214), Expect = 4e-17
Identities = 65/197 (32%), Positives = 103/197 (52%), Gaps = 3/197 (1%)
Query: 186 LTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESL 245
LT +PA S L+ L L+LS N L++LPA + +M+ L L + N L +P L + +L
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 246 ELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSV 304
L + N+L+ LP + S L+ L + +N ++ L E + L S+L L+L N+L+S+
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQSL 232
Query: 305 PDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQEVLK 363
P + LRSL L L +N ++S+P L L L L L N LR + E++ +
Sbjct: 233 PASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVRLQG 292
Query: 364 YLRSKIKDDGPSQSESA 380
+ D PS +A
Sbjct: 293 NPLGEASPDAPSSPVAA 309
Score = 78.2 bits (191), Expect = 2e-14
Identities = 70/195 (35%), Positives = 98/195 (50%), Gaps = 12/195 (6%)
Query: 170 FEQLSNLEDLDLSNNHLTTVPASFSSLSSLV------RLNLSS---NELKSLPAEINRMK 220
F +LS ED L L +P S S L SLV R L + L +LPA ++ +
Sbjct: 66 FLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLA 125
Query: 221 RLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKELHVGENQIEM 279
L HLD + N LET+P + M L L L N L LPE + L L V N+++
Sbjct: 126 HLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQT 185
Query: 280 LEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKF 338
L L L+++ LDL N L ++P EI L SL L+L++N + SLP SL L L+
Sbjct: 186 LPPA-LGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRL 244
Query: 339 LALEGNPLRTIRREI 353
L L N L ++ ++
Sbjct: 245 LVLHSNLLASVPADL 259
Score = 69.7 bits (169), Expect = 7e-12
Identities = 49/144 (34%), Positives = 78/144 (54%), Gaps = 5/144 (3%)
Query: 433 SKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEME 492
S N L E+P+ + L + + ++ N+L + L L L LDL N L++LP E+
Sbjct: 156 SHNCLSELPEALGALPALTF-LTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIG 214
Query: 493 SLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNN 552
L L +NL+ NR + LP L + +L +++ +N + SV P + + LT LDL++N
Sbjct: 215 GLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASV-PADLARLPLLTRLDLRDN 273
Query: 553 DLLQIPPELGNCVNLRTLLLDGNP 576
L +PPEL + +R L GNP
Sbjct: 274 QLRDLPPELLDAPFVR---LQGNP 294
Score = 60.8 bits (146), Expect = 3e-09
Identities = 43/127 (33%), Positives = 71/127 (55%), Gaps = 5/127 (3%)
Query: 451 VSDVDLSFNKLSFISLELCVLQK--LTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFK 508
++ +DLSFN L +L CVLQ L L L +N L+ LPE + +L L + ++ NR +
Sbjct: 127 LAHLDLSFNSLE--TLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQ 184
Query: 509 MLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLR 568
LP L + TL+ + +S N + ++ P+ + + +L L+L +N L +P L +LR
Sbjct: 185 TLPPALGALSTLQRLDLSQNLLDTLPPE-IGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 569 TLLLDGN 575
L+L N
Sbjct: 244 LLVLHSN 250
Score = 47.0 bits (110), Expect = 5e-05
Identities = 29/92 (31%), Positives = 49/92 (53%), Gaps = 1/92 (1%)
Query: 484 LNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMEN 543
L +LP + L L ++LSFN + LP + ++ L +L+S+N + + P+ + +
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSEL-PEALGALPA 172
Query: 544 LTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
LT L + +N L +PP LG L+ L L N
Sbjct: 173 LTFLTVTHNRLQTLPPALGALSTLQRLDLSQN 204
Score = 47.0 bits (110), Expect = 5e-05
Identities = 34/105 (32%), Positives = 52/105 (49%), Gaps = 1/105 (0%)
Query: 471 LQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQV 530
L L LDL N L +LP + + L + LS N LPE L + L + +++N++
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 531 GSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
++ P + + L LDL N L +PPE+G +L L L N
Sbjct: 184 QTL-PPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASN 227
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 108 bits (270), Expect = 1e-23
Identities = 72/207 (34%), Positives = 112/207 (54%), Gaps = 8/207 (3%)
Query: 169 GFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCN 228
G LS++ L LS+N LT VP + + L +L LN +N+++ LP +I+ +++LKHL+
Sbjct: 35 GLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLG 94
Query: 229 SNLLETIPPELAGMESLELLYLRRNKL--RFLP-EFPSCSLLKELHVGENQIEMLEAEHL 285
N L T+P + +LE+L L N L LP F + L+ L++ +N E+L + +
Sbjct: 95 MNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPD-I 153
Query: 286 KHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHL----KFLAL 341
L + +L LRDN L S+P EI L L+ L + N ++ LP LGNL L +
Sbjct: 154 GKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKA 213
Query: 342 EGNPLRTIRREIISKGTQEVLKYLRSK 368
E NP T + G V +Y+RS+
Sbjct: 214 ENNPWVTPIADQFQLGVSHVFEYIRSE 240
Score = 98.6 bits (244), Expect = 1e-20
Identities = 58/158 (36%), Positives = 97/158 (61%), Gaps = 2/158 (1%)
Query: 104 LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNEL 163
L +T L + N+LT +P I EL+NL+ LN +N+++ LP +I++L+ LK L L N L
Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRL 98
Query: 164 TCISEGFEQLSNLEDLDLSNNHLT--TVPASFSSLSSLVRLNLSSNELKSLPAEINRMKR 221
+ GF L LE LDL+ N+L+ ++P +F L++L L LS N+ + LP +I ++ +
Sbjct: 99 NTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK 158
Query: 222 LKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
L+ L N L ++P E+ + L+ L+++ N+L LP
Sbjct: 159 LQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLP 196
Score = 96.3 bits (238), Expect = 7e-20
Identities = 57/162 (35%), Positives = 89/162 (54%), Gaps = 2/162 (1%)
Query: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
+T+L++S+NKL + ++ L L VL+ +NQ+ LP+ I L+ L+ LN+ N+L L
Sbjct: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
Query: 144 PEEITNLRNLKCLYLQHNELT--CISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
P +L L+ L L +N L+ + F L+ L L LS+N +P L+ L
Sbjct: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQI 161
Query: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME 243
L+L N+L SLP EI + +LK L N L +PPEL ++
Sbjct: 162 LSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGNLD 203
Score = 63.5 bits (153), Expect = 5e-10
Identities = 44/154 (28%), Positives = 73/154 (47%), Gaps = 26/154 (16%)
Query: 451 VSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKML 510
++ + LS NKL+ + + L+ L L+ NN + LP ++ SL +L+ +NL NR L
Sbjct: 42 ITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTL 101
Query: 511 P---------EVL----------------YRIFTLETILISNNQVGSVDPQKMKMMENLT 545
P EVL + + TL + +S+N + P K+ + L
Sbjct: 102 PRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTK-LQ 160
Query: 546 TLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 579
L L++NDL+ +P E+G L+ L + GN V
Sbjct: 161 ILSLRDNDLISLPKEIGELTQLKELHIQGNRLTV 194
Score = 62.0 bits (149), Expect = 2e-09
Identities = 61/219 (27%), Positives = 98/219 (44%), Gaps = 26/219 (11%)
Query: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LK 337
ML+ L L+ I L L NKL VP I L++LE L+ NN I LP + +L LK
Sbjct: 30 MLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLK 89
Query: 338 FLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHA 397
L L N L T+ R S EVL + + ++ +LP N
Sbjct: 90 HLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEN-------------SLPG----NFFY 132
Query: 398 IITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLS 457
+ TL+ L SD ++P ++ K I ++ N L +PK + EL ++ ++ +
Sbjct: 133 LTTLRALYLSDNDFEILPPDIGKLTKLQI---LSLRDNDLISLPKEIGELTQL-KELHIQ 188
Query: 458 FNKLSFISLELCVL----QKLTFLDLRNNFLNSLPEEME 492
N+L+ + EL L QK F N ++ + ++ +
Sbjct: 189 GNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQ 227
Score = 57.0 bits (136), Expect = 5e-08
Identities = 37/121 (30%), Positives = 64/121 (52%), Gaps = 2/121 (1%)
Query: 32 LKAARKSGQLNLSGRNLSEVPQCVWRIN-VDIPEEANQNLSFGATE-RWWEQTDLTKLII 89
+ + +K LNL L+ +P+ + +++ + NLS + ++ T L L +
Sbjct: 82 ISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYL 141
Query: 90 SNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPEEITN 149
S+N + L D+ L L +L + DN L SLP I EL L++L++ N+L +LP E+ N
Sbjct: 142 SDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPELGN 201
Query: 150 L 150
L
Sbjct: 202 L 202
Score = 55.1 bits (131), Expect = 2e-07
Identities = 53/209 (25%), Positives = 89/209 (42%), Gaps = 33/209 (15%)
Query: 394 NIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSD 453
NI + L++L++ + Q +P ++ K + +N N+L +P+ L +
Sbjct: 58 NIAELKNLEVLNFFNNQIEELPTQISSLQK---LKHLNLGMNRLNTLPRGFGSLPAL-EV 113
Query: 454 VDLSFNKLSFISL--ELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLP 511
+DL++N LS SL L L L L +N LP ++ L +LQ ++L N LP
Sbjct: 114 LDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLP 173
Query: 512 EVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGN---CVNLR 568
+ ++G + L L +Q N L +PPELGN +
Sbjct: 174 K----------------EIGE--------LTQLKELHIQGNRLTVLPPELGNLDLTGQKQ 209
Query: 569 TLLLDGNPFRVPRAAILMKGTAAILEYLR 597
+ NP+ P A G + + EY+R
Sbjct: 210 VFKAENNPWVTPIADQFQLGVSHVFEYIR 238
Score = 47.4 bits (111), Expect = 4e-05
Identities = 37/98 (37%), Positives = 49/98 (50%), Gaps = 6/98 (6%)
Query: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139
E DLT +S N SL + L L L + DN LP I +L LQ L++ N
Sbjct: 112 EVLDLTYNNLSEN---SLPGNFFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDND 168
Query: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLE 177
L LP+EI L LK L++Q N LT + +L NL+
Sbjct: 169 LISLPKEIGELTQLKELHIQGNRLTVLP---PELGNLD 203
Score = 33.5 bits (75), Expect = 0.58
Identities = 23/83 (27%), Positives = 40/83 (48%), Gaps = 1/83 (1%)
Query: 493 SLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNN 552
+L + + LS N+ M+P + + LE + NNQ+ + P ++ ++ L L+L N
Sbjct: 38 TLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL-PTQISSLQKLKHLNLGMN 96
Query: 553 DLLQIPPELGNCVNLRTLLLDGN 575
L +P G+ L L L N
Sbjct: 97 RLNTLPRGFGSLPALEVLDLTYN 119
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 108 bits (269), Expect = 2e-23
Identities = 83/243 (34%), Positives = 118/243 (48%), Gaps = 41/243 (16%)
Query: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
+T I + LS ++ L+LS+N L +P L+ +V LNL N LKSLP E++ ++ L
Sbjct: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
Query: 223 KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP--------------------EFP 262
K L N N L +P EL+ LE+L L N L LP P
Sbjct: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
Query: 263 SCSL-LKEL---HVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLD 318
C LKEL HVG N++E + AE ++HL S+ + N + S P + L+ SLE L+
Sbjct: 180 MCVFSLKELIFLHVGSNRLENI-AESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLN 238
Query: 319 LSNNDISSLPYSLGNLHL-------------KFLALEGNPLRTIRREIISKGTQEVLKYL 365
L+NNDI +LP LHL K L + NPL E++ G + + YL
Sbjct: 239 LNNNDIQTLP---SELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYL 295
Query: 366 RSK 368
+ K
Sbjct: 296 KDK 298
Score = 101 bits (252), Expect = 2e-21
Identities = 82/291 (28%), Positives = 135/291 (46%), Gaps = 38/291 (13%)
Query: 20 GRDCGTSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWW 79
GRD P+ LLK +L R ++++P +W ++
Sbjct: 37 GRD-----PRSLLKRGMHHVSFSLVTRGMTDIPDFLWGLS-------------------- 71
Query: 80 EQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNK 139
++ KL +S+N+L+ L ++ L + VL++ N+L SLP + L+ L+ L V+ N
Sbjct: 72 ---EVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCLKVLFVNMNC 128
Query: 140 LKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSL 199
L +P E++ R L+ L L HN L+ + F LS L L+LSNN +P SL L
Sbjct: 129 LTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKEL 188
Query: 200 VRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP 259
+ L++ SN L+++ I + L+ N + + P L + SLELL L N ++ LP
Sbjct: 189 IFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNLNNNDIQTLP 248
Query: 260 E--FPSCSLL--------KELHVGENQIEMLEAEHLKHLNSILVLDLRDNK 300
C L+ K LH+ N + E ++ +L L+D K
Sbjct: 249 SELHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDKK 299
Score = 65.1 bits (157), Expect = 2e-10
Identities = 57/228 (25%), Positives = 100/228 (43%), Gaps = 37/228 (16%)
Query: 404 LDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSF 463
L+ S Q ++P EV + + +N N+L +P R V L + + + ++ N L+
Sbjct: 76 LNLSHNQLRVLPPEVGKLTR---IVVLNLCGNRLKSLP-REVSLLQCLKVLFVNMNCLTE 131
Query: 464 ISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLP------------ 511
+ EL + +KL L L +N L+ LP L RL+ +NLS N F +P
Sbjct: 132 VPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIPMCVFSLKELIFL 191
Query: 512 -----------EVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPE 560
E + + +L+ + N + S P+ + ++ +L L+L NND+ +P E
Sbjct: 192 HVGSNRLENIAESIQHLASLQIFIAEGNNIHSF-PRSLCLVTSLELLNLNNNDIQTLPSE 250
Query: 561 LGNCVNL---------RTLLLDGNPFRVPRAAILMKGTAAILEYLRDR 599
L L + L + NP P ++ G + YL+D+
Sbjct: 251 LHLLCRLVRIAWNPMDKGLHISHNPLSKPLPELVEGGLEMLFGYLKDK 298
Score = 45.8 bits (107), Expect = 1e-04
Identities = 36/122 (29%), Positives = 60/122 (49%), Gaps = 2/122 (1%)
Query: 437 LCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496
+ +IP + L E V ++LS N+L + E+ L ++ L+L N L SLP E+ L
Sbjct: 60 MTDIPDFLWGLSE-VQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQC 118
Query: 497 LQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQ 556
L+ + ++ N +P L LE + +S+N + + P + L L+L NN
Sbjct: 119 LKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQL-PACFADLSRLRKLNLSNNFFAH 177
Query: 557 IP 558
IP
Sbjct: 178 IP 179
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 106 bits (265), Expect = 5e-23
Identities = 86/306 (28%), Positives = 147/306 (48%), Gaps = 37/306 (12%)
Query: 57 RINVDIPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQ 116
++N D+ E + W E+ LTKL + + +D R+ +L I +
Sbjct: 24 KLNEDLKRE--KEFQHKLVRIWEERVSLTKL-----REKVTREDGRV-----ILKIEKEE 71
Query: 117 LTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNL 176
+LPS++ +L LQ+ + L +PE I +NL L L N ++ I G L+ L
Sbjct: 72 WKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRL 131
Query: 177 EDLDLSNNHLTTVPASFSSLSSLVRLNLSSN-ELKSLPAEINRMKRLKHLDCNSNLLETI 235
++L LS N + TVP S+ +SL +L L+ N ++ LP E++ + +L HLD + N TI
Sbjct: 132 QELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTI 191
Query: 236 PPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLD 295
P + M +LE L + NKL LP + ++ + ++ L
Sbjct: 192 PLAVLNMPALEWLDMGSNKLEQLP-----------------------DTIERMQNLHTLW 228
Query: 296 LRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREII 354
L+ N++ +P I +++L L LSNN + +P + + +L+F+ NPL+
Sbjct: 229 LQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPLKLKVSLPP 288
Query: 355 SKGTQE 360
S+GT E
Sbjct: 289 SEGTDE 294
Score = 82.0 bits (201), Expect = 1e-15
Identities = 61/194 (31%), Positives = 96/194 (49%), Gaps = 10/194 (5%)
Query: 30 GLLKAARKSGQ------LNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTD 83
GLLK G+ L+LS +SE+P + + + N +
Sbjct: 94 GLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQELILSYNKIKTVPKELSNCAS 153
Query: 84 LTKLIISNNK-LQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI 142
L KL ++ N+ + L +L L LT LD+ N T++P A+ + L+ L++ NKL+
Sbjct: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
Query: 143 LPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRL 202
LP+ I ++NL L+LQ NE+TC+ + + NL L LSNN L +P +++L +
Sbjct: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFV 273
Query: 203 NLSSNELK---SLP 213
N N LK SLP
Sbjct: 274 NFRDNPLKLKVSLP 287
Score = 73.9 bits (180), Expect = 4e-13
Identities = 63/223 (28%), Positives = 108/223 (48%), Gaps = 25/223 (11%)
Query: 362 LKYLRSKI-KDDGPSQSESATETAMTLPSE-------SRVNIHAIITLKILDYSDKQATL 413
L LR K+ ++DG + E TLPS +H LKI ++ + L
Sbjct: 49 LTKLREKVTREDGRVILKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNL 108
Query: 414 IPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQK 473
I ++ S+N + EIP + L + ++ LS+NK+ + EL
Sbjct: 109 IV--------------LDLSRNTISEIPPG-IGLLTRLQELILSYNKIKTVPKELSNCAS 153
Query: 474 LTFLDLR-NNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532
L L+L N + LP+E+ +L++L ++LS N F +P + + LE + + +N++
Sbjct: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
Query: 533 VDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
+ P ++ M+NL TL LQ N++ +P + N NL TL+L N
Sbjct: 214 L-PDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNN 255
Score = 65.1 bits (157), Expect = 2e-10
Identities = 47/178 (26%), Positives = 91/178 (51%), Gaps = 9/178 (5%)
Query: 389 SESRVNIHAIITLKILDYSDKQATLIPDEVFDAVK-SNIVTSINFSKNQLCEIPKRMVEL 447
SE I + L+ L S + +P E+ + + ++N +C++P+ + L
Sbjct: 119 SEIPPGIGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVN---RDICDLPQELSNL 175
Query: 448 KEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRF 507
++ + +DLS N + I L + + L +LD+ +N L LP+ +E + L T+ L N
Sbjct: 176 LKL-THLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEI 234
Query: 508 KMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL---LQIPPELG 562
LP+ + + L T+++SNN++ + P M+ M NL ++ ++N L + +PP G
Sbjct: 235 TCLPQTISNMKNLGTLVLSNNKLQDI-PVCMEEMANLRFVNFRDNPLKLKVSLPPSEG 291
>gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens]
Length = 2015
Score = 105 bits (262), Expect = 1e-22
Identities = 108/364 (29%), Positives = 164/364 (45%), Gaps = 49/364 (13%)
Query: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQ--------CVWRINVDIPEEANQNLSFGATERW 78
+P GL+ + LNLS +L E+P C + +DI +L G +
Sbjct: 297 IPWGLINLRK----LNLSDNHLGELPGVQSSDEIICSRLLEIDISSNKLSHLPPG----F 348
Query: 79 WEQTDLTKLIISNNKLQSLTDDLRL-----LPALTVLDIHDNQLTSLPSA-IRELENLQK 132
+ L KL S N L+ L ++ L L LDI DN+LT LP+ + ++L
Sbjct: 349 LHLSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPALFLHSFKSLNS 408
Query: 133 LNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQL--SNLEDLDLSNNHLTTVP 190
LNVS N LK+ P+ LKC N L C+ + ++L+D+D S N L VP
Sbjct: 409 LNVSRNNLKVFPDPWAC--PLKCCKASRNALECLPDKMAVFWKNHLKDVDFSENALKEVP 466
Query: 191 ASFSSLSSLVRLNLSSNELKSLPAEIN-RMKRLKHLDCNSNLLETIPPELAGMESLEL-L 248
L +L+ L L N+L +LP + ++LK LD + N L G+++ +
Sbjct: 467 LGLFQLDALMFLRLQGNQLAALPPQEKWTCRQLKTLDLSRNQL---GKNEDGLKTKRIAF 523
Query: 249 YLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEI 308
+ R + R G +LE S+ VL L DN L +VP +
Sbjct: 524 FTTRGRQR---------------SGTEAASVLEFPAFLS-ESLEVLCLNDNHLDTVPPSV 567
Query: 309 ILLRSLERLDLSNN-DISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLR 366
LL+SL L L NN + LP LG L +L L E + + EI +G + +L YLR
Sbjct: 568 CLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLR 627
Query: 367 SKIK 370
++++
Sbjct: 628 AQLR 631
Score = 72.8 bits (177), Expect = 9e-13
Identities = 102/374 (27%), Positives = 163/374 (43%), Gaps = 56/374 (14%)
Query: 263 SCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVP-----DEIILLRSLERL 317
SC + EL + N + L + L ++ L+L DN L +P DEII R LE +
Sbjct: 277 SCQIT-ELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLE-I 334
Query: 318 DLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQS 377
D+S+N +S LP G LHL L ++ SK E L + G +
Sbjct: 335 DISSNKLSHLPP--GFLHLSKL----------QKLTASKNCLEKLFEEENATNWIGLRKL 382
Query: 378 ESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQL 437
+ + L + +H+ +L L+ S + PD +K S+N L
Sbjct: 383 QELDISDNKLTELPALFLHSFKSLNSLNVSRNNLKVFPDPWACPLKC-----CKASRNAL 437
Query: 438 CEIPKRM-VELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLP-EEMESLV 495
+P +M V K + DVD S N L + L L L L FL L+ N L +LP +E +
Sbjct: 438 ECLPDKMAVFWKNHLKDVDFSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCR 497
Query: 496 RLQTINLSFNRF----------------------------KMLPEVLYRIFTLETILISN 527
+L+T++LS N+ +L + +LE + +++
Sbjct: 498 QLKTLDLSRNQLGKNEDGLKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSESLEVLCLND 557
Query: 528 NQVGSVDPQKMKMMENLTTLDLQNND-LLQIPPELGNCVNLRTLLLDGNPFRVPRAAILM 586
N + +V P + ++++L+ L L NN L ++PPELG NL L + A I
Sbjct: 558 NHLDTVPPS-VCLLKSLSELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQK 616
Query: 587 KGTAAILEYLRDRI 600
+G A+L YLR ++
Sbjct: 617 EGPKAMLSYLRAQL 630
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 103 bits (256), Expect = 6e-22
Identities = 113/400 (28%), Positives = 172/400 (43%), Gaps = 49/400 (12%)
Query: 110 LDIHDNQLTSLPS-AIRELENLQKLNVSHNKLKIL-PEEITNLRNLKCLYLQHNELTCI- 166
LDI N +T LP A + L++L ++ N L + P+ ++ L+ LK L LQ+N+L +
Sbjct: 62 LDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVP 121
Query: 167 SEGFEQLSNLEDLDLSNNHLTTVPA-SFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHL 225
SE LS L+ L L NH+T+VP SF L L L L N L +P
Sbjct: 122 SEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVH---------- 171
Query: 226 DCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSL--LKELHVGENQIEMLEAE 283
L+ + +L+ L L NK+ +P+F +L L LH+ N+I L
Sbjct: 172 ------------PLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQH 219
Query: 284 HLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSL--GNLHLKFLAL 341
L+++ LDL N L P I L SL+ L +N IS +P GN L+ + L
Sbjct: 220 CFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHL 279
Query: 342 EGNPLRTI----------RREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSES 391
NPL + ++ +G V ++ G ES T T + S
Sbjct: 280 YDNPLSFVGNSAFHNLSDLHSLVIRGASMVQQFPNL----TGTVHLESLTLTGTKISSIP 335
Query: 392 RVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMV 451
L+ LD S +P F+ + + I+ +NQ+ +I + + +
Sbjct: 336 NNLCQEQKMLRTLDLSYNNIRDLPS--FNG--CHALEEISLQRNQIYQIKEGTFQGLISL 391
Query: 452 SDVDLSFNKLSFI-SLELCVLQKLTFLDLRNNFLNSLPEE 490
+DLS N + I S L +T LD+ N L S P E
Sbjct: 392 RILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTE 431
Score = 99.0 bits (245), Expect = 1e-20
Identities = 121/488 (24%), Positives = 217/488 (44%), Gaps = 78/488 (15%)
Query: 25 TSVPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPEEANQNLSFGATERWWEQTDL 84
T+VP+GL + L++S N+++ +PE+A +N F L
Sbjct: 49 TAVPEGLSAFTQA---LDISMNNITQ-----------LPEDAFKNFPF-----------L 83
Query: 85 TKLIISNNKLQSLTDD-LRLLPALTVLDIHDNQLTSLPS-AIRELENLQKLNVSHNKLKI 142
+L ++ N L + L L L VL + +NQL ++PS AIR L LQ L + N +
Sbjct: 84 EELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITS 143
Query: 143 LPEE-ITNLRNLKCLYLQHNELTCIS-EGFEQLSNLEDLDLSNNHLTTVP-ASFSSLSSL 199
+PE+ L L+ L+L N LT + L L+ L L+ N ++++P +F++LSSL
Sbjct: 144 VPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSL 203
Query: 200 VRLNLSSNELKSLPAE-INRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFL 258
V L+L +N+++SL + + L+ LD N N L P + + SL+ L N + +
Sbjct: 204 VVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVI 263
Query: 259 PE--FPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLER 316
P+ F LL+ +H+ +N + + +L+ + L +R +
Sbjct: 264 PDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASM--------------- 308
Query: 317 LDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQ 376
+ P G +HL+ L L G + +I + + Q++L+ L
Sbjct: 309 -------VQQFPNLTGTVHLESLTLTGTKISSIPNNLCQE--QKMLRTL----------- 348
Query: 377 SESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQ 436
+ + LPS + HA L+ + Q I + F + S + ++ S+N
Sbjct: 349 -DLSYNNIRDLPSFN--GCHA---LEEISLQRNQIYQIKEGTFQGLIS--LRILDLSRNL 400
Query: 437 LCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVR 496
+ EI R ++++D+SFN+L+ E L L L L NF + V
Sbjct: 401 IHEIHSRAFATLGPITNLDVSFNELTSFPTE--GLNGLNQLKLVGNFKLKEALAAKDFVN 458
Query: 497 LQTINLSF 504
L+++++ +
Sbjct: 459 LRSLSVPY 466
Score = 89.7 bits (221), Expect = 7e-18
Identities = 114/444 (25%), Positives = 186/444 (41%), Gaps = 78/444 (17%)
Query: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPA-SFSSLSSLVRLNLSSNELKSL-PAEINRMK 220
LT + EG + + LD+S N++T +P +F + L L L+ N+L + P ++ +K
Sbjct: 48 LTAVPEGLSAFT--QALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLK 105
Query: 221 RLKHLDCNSNLLETIPPE-LAGMESLELLYLRRNKLRFLPE--FPSCSLLKELHVGENQI 277
LK L +N L+T+P E + G+ +L+ L L N + +PE F L+ L + +N +
Sbjct: 106 ELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSL 165
Query: 278 EMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL-LRSLERLDLSNNDISSLPYSL--GNL 334
+ L +L ++ L L NK+ S+PD L SL L L NN I SL G
Sbjct: 166 TEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLD 225
Query: 335 HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVN 394
+L+ L L N L E
Sbjct: 226 NLETLDLNYNNL------------------------------------------GEFPQA 243
Query: 395 IHAIITLKILDYSDKQATLIPDEVFDA--------VKSNIVTSI-NFSKNQLCEIPKRMV 445
I A+ +LK L + ++IPD FD + N ++ + N + + L ++ ++
Sbjct: 244 IKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVI 303
Query: 446 ELKEMVSD------------VDLSFNKLSFISLELCVLQK-LTFLDLRNNFLNSLPEEME 492
MV + L+ K+S I LC QK L LDL N + LP
Sbjct: 304 RGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDLPS-FN 362
Query: 493 SLVRLQTINLSFNRFKMLPEVLYR-IFTLETILISNNQVGSVDPQKMKMMENLTTLDLQN 551
L+ I+L N+ + E ++ + +L + +S N + + + + +T LD+
Sbjct: 363 GCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSF 422
Query: 552 NDLLQIPPELGNCVNLRTLLLDGN 575
N+L P E N L L L GN
Sbjct: 423 NELTSFPTEGLN--GLNQLKLVGN 444
Score = 49.3 bits (116), Expect = 1e-05
Identities = 48/227 (21%), Positives = 92/227 (40%), Gaps = 56/227 (24%)
Query: 404 LDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSF 463
+D S K T +P+ + S +++ S N + ++P+ + + ++ L+ N LSF
Sbjct: 41 VDCSGKGLTAVPEGL-----SAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSF 95
Query: 464 ISLE-LCVLQKLTFLDLRNNFLNSLPEE-------------------------------- 490
I + L L++L L L+NN L ++P E
Sbjct: 96 IHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQL 155
Query: 491 -----------------MESLVRLQTINLSFNRFKMLPEVLY-RIFTLETILISNNQVGS 532
+ +L LQ + L+ N+ +P+ + + +L + + NN++ S
Sbjct: 156 RHLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRS 215
Query: 533 VDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGNPFRV 579
+ ++NL TLDL N+L + P + +L+ L N V
Sbjct: 216 LSQHCFDGLDNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISV 262
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 102 bits (255), Expect = 8e-22
Identities = 68/227 (29%), Positives = 120/227 (52%), Gaps = 5/227 (2%)
Query: 47 NLSEVPQCVWRINVDIPEEA--NQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLL 104
NLS++PQ V + V + + + N+ + +LT+L + L+ + + L
Sbjct: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL 613
Query: 105 PALTVLDIHDNQLTSLPSAI--RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNE 162
L +D+ DN L ++ I + L L L + +N + +P +I NL NL+ LYL N+
Sbjct: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673
Query: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
+ I L LDLS+N+LT +PA L +L L +++N +++LP E+ + ++L
Sbjct: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKL 733
Query: 223 KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLK 268
+ L +N+L+++P + + +L + LR N+L LP E C LLK
Sbjct: 734 RALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 83.6 bits (205), Expect = 5e-16
Identities = 116/442 (26%), Positives = 199/442 (45%), Gaps = 66/442 (14%)
Query: 135 VSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLED-LDLSNNHLTTVPASF 193
VS NKL+ L NL N L LT N +D L+L L+ +P +
Sbjct: 397 VSENKLRQL-----NLNNEWTLDKLRQRLT---------KNAQDKLELHLFMLSGIPDTV 442
Query: 194 SSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGM-ESLELLYLRR 252
L L L L ++P I ++ LK L + P LA + E+L L+++
Sbjct: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKF 502
Query: 253 NKLRFLPEFP-SCSLLKELHVGENQIEMLEAEHLKHLNSILVLD-LRDNKLKSVPDEIIL 310
++ +P + S L+ELH+ N L AE+ N +V+D LR+
Sbjct: 503 TDIKEIPLWIYSLKTLEELHLTGN----LSAEN----NRYIVIDGLRE------------ 542
Query: 311 LRSLERLDLSNNDISSLPYSLGNL--HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 368
L+ L+ L L +N +S LP + ++ HL+ L++ + I VL L+
Sbjct: 543 LKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLI-----------VLNSLK-- 588
Query: 369 IKDDGPSQSESATETAMTLPSESRV--NIHAIITLKILDYSDKQATLIPDEVFDAVKSNI 426
+ + TE + R+ +I ++ L+ +D D I +E+ +
Sbjct: 589 -------KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI-EEIISFQHLHR 640
Query: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486
+T + N + IP ++ L + + L+ NK+ I +L +KL +LDL +N L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNL-ERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699
Query: 487 LPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTT 546
LP ++ L LQ + ++ NR + LP L++ L + + NN + S+ P ++ + NLT
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSL-PSRVGELTNLTQ 758
Query: 547 LDLQNNDLLQIPPELGNCVNLR 568
++L+ N L +P ELG C L+
Sbjct: 759 IELRGNRLECLPVELGECPLLK 780
Score = 76.3 bits (186), Expect = 8e-14
Identities = 48/160 (30%), Positives = 78/160 (48%), Gaps = 25/160 (15%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
T+L +L ++ NK++ + L L LD+ N LT LP+ I L+NLQ L ++ N+++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
Query: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
LP E+ R L+ L+ L NN L ++P+ L++L +
Sbjct: 722 TLPPELFQCRKLRALH-----------------------LGNNVLQSLPSRVGELTNLTQ 758
Query: 202 LNLSSNELKSLPAEINRMKRLKH--LDCNSNLLETIPPEL 239
+ L N L+ LP E+ LK L +L T+PPE+
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 67.4 bits (163), Expect = 4e-11
Identities = 93/404 (23%), Positives = 164/404 (40%), Gaps = 64/404 (15%)
Query: 174 SNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233
+ L L+L+N + ++ +L L L +P + + L+ L
Sbjct: 400 NKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
Query: 234 TIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
TIPP +A + L+ L+L + E P+ + L+E L A H+K +
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKI--EAPALAFLRE---------NLRALHIKFTD---- 504
Query: 294 LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREI 353
+K +P I L++LE L L+ N L+ E N R I
Sbjct: 505 -------IKEIPLWIYSLKTLEELHLTGN----------------LSAENN------RYI 535
Query: 354 ISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATL 413
+ G +E+ + ++K + + T+ + L S N L +L+ K A L
Sbjct: 536 VIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGT--KLIVLNSLKKMANL 593
Query: 414 IPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFIS--LELCVL 471
T + + L IP + L + ++DL N L I + L
Sbjct: 594 --------------TELELIRCDLERIPHSIFSLHNL-QEIDLKDNNLKTIEEIISFQHL 638
Query: 472 QKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVG 531
+LT L L N + +P ++ +L L+ + L+ N+ + +P L+ L + +S+N +
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 532 SVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
+ P + +++NL L + N + +PPEL C LR L L N
Sbjct: 699 FL-PADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 102 bits (255), Expect = 8e-22
Identities = 68/227 (29%), Positives = 120/227 (52%), Gaps = 5/227 (2%)
Query: 47 NLSEVPQCVWRINVDIPEEA--NQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLL 104
NLS++PQ V + V + + + N+ + +LT+L + L+ + + L
Sbjct: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL 613
Query: 105 PALTVLDIHDNQLTSLPSAI--RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNE 162
L +D+ DN L ++ I + L L L + +N + +P +I NL NL+ LYL N+
Sbjct: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673
Query: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
+ I L LDLS+N+LT +PA L +L L +++N +++LP E+ + ++L
Sbjct: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKL 733
Query: 223 KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLK 268
+ L +N+L+++P + + +L + LR N+L LP E C LLK
Sbjct: 734 RALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 83.6 bits (205), Expect = 5e-16
Identities = 116/442 (26%), Positives = 199/442 (45%), Gaps = 66/442 (14%)
Query: 135 VSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLED-LDLSNNHLTTVPASF 193
VS NKL+ L NL N L LT N +D L+L L+ +P +
Sbjct: 397 VSENKLRQL-----NLNNEWTLDKLRQRLT---------KNAQDKLELHLFMLSGIPDTV 442
Query: 194 SSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGM-ESLELLYLRR 252
L L L L ++P I ++ LK L + P LA + E+L L+++
Sbjct: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKF 502
Query: 253 NKLRFLPEFP-SCSLLKELHVGENQIEMLEAEHLKHLNSILVLD-LRDNKLKSVPDEIIL 310
++ +P + S L+ELH+ N L AE+ N +V+D LR+
Sbjct: 503 TDIKEIPLWIYSLKTLEELHLTGN----LSAEN----NRYIVIDGLRE------------ 542
Query: 311 LRSLERLDLSNNDISSLPYSLGNL--HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 368
L+ L+ L L +N +S LP + ++ HL+ L++ + I VL L+
Sbjct: 543 LKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLI-----------VLNSLK-- 588
Query: 369 IKDDGPSQSESATETAMTLPSESRV--NIHAIITLKILDYSDKQATLIPDEVFDAVKSNI 426
+ + TE + R+ +I ++ L+ +D D I +E+ +
Sbjct: 589 -------KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI-EEIISFQHLHR 640
Query: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486
+T + N + IP ++ L + + L+ NK+ I +L +KL +LDL +N L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNL-ERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699
Query: 487 LPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTT 546
LP ++ L LQ + ++ NR + LP L++ L + + NN + S+ P ++ + NLT
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSL-PSRVGELTNLTQ 758
Query: 547 LDLQNNDLLQIPPELGNCVNLR 568
++L+ N L +P ELG C L+
Sbjct: 759 IELRGNRLECLPVELGECPLLK 780
Score = 76.3 bits (186), Expect = 8e-14
Identities = 48/160 (30%), Positives = 78/160 (48%), Gaps = 25/160 (15%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
T+L +L ++ NK++ + L L LD+ N LT LP+ I L+NLQ L ++ N+++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
Query: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
LP E+ R L+ L+ L NN L ++P+ L++L +
Sbjct: 722 TLPPELFQCRKLRALH-----------------------LGNNVLQSLPSRVGELTNLTQ 758
Query: 202 LNLSSNELKSLPAEINRMKRLKH--LDCNSNLLETIPPEL 239
+ L N L+ LP E+ LK L +L T+PPE+
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 67.4 bits (163), Expect = 4e-11
Identities = 93/404 (23%), Positives = 164/404 (40%), Gaps = 64/404 (15%)
Query: 174 SNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233
+ L L+L+N + ++ +L L L +P + + L+ L
Sbjct: 400 NKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
Query: 234 TIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
TIPP +A + L+ L+L + E P+ + L+E L A H+K +
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKI--EAPALAFLRE---------NLRALHIKFTD---- 504
Query: 294 LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREI 353
+K +P I L++LE L L+ N L+ E N R I
Sbjct: 505 -------IKEIPLWIYSLKTLEELHLTGN----------------LSAENN------RYI 535
Query: 354 ISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATL 413
+ G +E+ + ++K + + T+ + L S N L +L+ K A L
Sbjct: 536 VIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGT--KLIVLNSLKKMANL 593
Query: 414 IPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFIS--LELCVL 471
T + + L IP + L + ++DL N L I + L
Sbjct: 594 --------------TELELIRCDLERIPHSIFSLHNL-QEIDLKDNNLKTIEEIISFQHL 638
Query: 472 QKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVG 531
+LT L L N + +P ++ +L L+ + L+ N+ + +P L+ L + +S+N +
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 532 SVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
+ P + +++NL L + N + +PPEL C LR L L N
Sbjct: 699 FL-PADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 102 bits (255), Expect = 8e-22
Identities = 68/227 (29%), Positives = 120/227 (52%), Gaps = 5/227 (2%)
Query: 47 NLSEVPQCVWRINVDIPEEA--NQNLSFGATERWWEQTDLTKLIISNNKLQSLTDDLRLL 104
NLS++PQ V + V + + + N+ + +LT+L + L+ + + L
Sbjct: 554 NLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSL 613
Query: 105 PALTVLDIHDNQLTSLPSAI--RELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNE 162
L +D+ DN L ++ I + L L L + +N + +P +I NL NL+ LYL N+
Sbjct: 614 HNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNK 673
Query: 163 LTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRL 222
+ I L LDLS+N+LT +PA L +L L +++N +++LP E+ + ++L
Sbjct: 674 IEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKL 733
Query: 223 KHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLP-EFPSCSLLK 268
+ L +N+L+++P + + +L + LR N+L LP E C LLK
Sbjct: 734 RALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLK 780
Score = 83.6 bits (205), Expect = 5e-16
Identities = 116/442 (26%), Positives = 199/442 (45%), Gaps = 66/442 (14%)
Query: 135 VSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLED-LDLSNNHLTTVPASF 193
VS NKL+ L NL N L LT N +D L+L L+ +P +
Sbjct: 397 VSENKLRQL-----NLNNEWTLDKLRQRLT---------KNAQDKLELHLFMLSGIPDTV 442
Query: 194 SSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGM-ESLELLYLRR 252
L L L L ++P I ++ LK L + P LA + E+L L+++
Sbjct: 443 FDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKF 502
Query: 253 NKLRFLPEFP-SCSLLKELHVGENQIEMLEAEHLKHLNSILVLD-LRDNKLKSVPDEIIL 310
++ +P + S L+ELH+ N L AE+ N +V+D LR+
Sbjct: 503 TDIKEIPLWIYSLKTLEELHLTGN----LSAEN----NRYIVIDGLRE------------ 542
Query: 311 LRSLERLDLSNNDISSLPYSLGNL--HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSK 368
L+ L+ L L +N +S LP + ++ HL+ L++ + I VL L+
Sbjct: 543 LKRLKVLRLKSN-LSKLPQVVTDVGVHLQKLSINNEGTKLI-----------VLNSLK-- 588
Query: 369 IKDDGPSQSESATETAMTLPSESRV--NIHAIITLKILDYSDKQATLIPDEVFDAVKSNI 426
+ + TE + R+ +I ++ L+ +D D I +E+ +
Sbjct: 589 -------KMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTI-EEIISFQHLHR 640
Query: 427 VTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNS 486
+T + N + IP ++ L + + L+ NK+ I +L +KL +LDL +N L
Sbjct: 641 LTCLKLWYNHIAYIPIQIGNLTNL-ERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTF 699
Query: 487 LPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTT 546
LP ++ L LQ + ++ NR + LP L++ L + + NN + S+ P ++ + NLT
Sbjct: 700 LPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSL-PSRVGELTNLTQ 758
Query: 547 LDLQNNDLLQIPPELGNCVNLR 568
++L+ N L +P ELG C L+
Sbjct: 759 IELRGNRLECLPVELGECPLLK 780
Score = 76.3 bits (186), Expect = 8e-14
Identities = 48/160 (30%), Positives = 78/160 (48%), Gaps = 25/160 (15%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
T+L +L ++ NK++ + L L LD+ N LT LP+ I L+NLQ L ++ N+++
Sbjct: 662 TNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIE 721
Query: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
LP E+ R L+ L+ L NN L ++P+ L++L +
Sbjct: 722 TLPPELFQCRKLRALH-----------------------LGNNVLQSLPSRVGELTNLTQ 758
Query: 202 LNLSSNELKSLPAEINRMKRLKH--LDCNSNLLETIPPEL 239
+ L N L+ LP E+ LK L +L T+PPE+
Sbjct: 759 IELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEV 798
Score = 67.4 bits (163), Expect = 4e-11
Identities = 93/404 (23%), Positives = 164/404 (40%), Gaps = 64/404 (15%)
Query: 174 SNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLE 233
+ L L+L+N + ++ +L L L +P + + L+ L
Sbjct: 400 NKLRQLNLNNEWTLDKLRQRLTKNAQDKLELHLFMLSGIPDTVFDLVELEVLKLELIPDV 459
Query: 234 TIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
TIPP +A + L+ L+L + E P+ + L+E L A H+K +
Sbjct: 460 TIPPSIAQLTGLKELWLYHTAAKI--EAPALAFLRE---------NLRALHIKFTD---- 504
Query: 294 LDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLALEGNPLRTIRREI 353
+K +P I L++LE L L+ N L+ E N R I
Sbjct: 505 -------IKEIPLWIYSLKTLEELHLTGN----------------LSAENN------RYI 535
Query: 354 ISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATL 413
+ G +E+ + ++K + + T+ + L S N L +L+ K A L
Sbjct: 536 VIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGT--KLIVLNSLKKMANL 593
Query: 414 IPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFIS--LELCVL 471
T + + L IP + L + ++DL N L I + L
Sbjct: 594 --------------TELELIRCDLERIPHSIFSLHNL-QEIDLKDNNLKTIEEIISFQHL 638
Query: 472 QKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVG 531
+LT L L N + +P ++ +L L+ + L+ N+ + +P L+ L + +S+N +
Sbjct: 639 HRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLT 698
Query: 532 SVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLDGN 575
+ P + +++NL L + N + +PPEL C LR L L N
Sbjct: 699 FL-PADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNN 741
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 102 bits (253), Expect = 1e-21
Identities = 107/403 (26%), Positives = 173/403 (42%), Gaps = 49/403 (12%)
Query: 105 PALTVLDIHDNQLTSL-PSAIRELENLQKLNVSHNKLKILP-EEITNLRNLKCLYLQHNE 162
P LD+ N LT L P L L++L +S N L +P + + L +LK L LQ+N+
Sbjct: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125
Query: 163 LTCI-SEGFEQLSNLEDLDLSNNHLTTVPA-SFSSLSSLVRLNLSSNELKSLPAEINRMK 220
L I +E +L +L+ L L N ++ VP SF LSSL L L N L +P
Sbjct: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRA---- 181
Query: 221 RLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE--FPSCSLLKELHVGENQIE 278
L + +L+ + L N++ +P+ F + + L LH+ N+I+
Sbjct: 182 ------------------LNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQ 223
Query: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYS--LGNLHL 336
L + L+++ LDL NKL+ P I L L+ L NN+I ++P +GN L
Sbjct: 224 HLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLL 283
Query: 337 KFLALEGNPLRTIRREIIS----------KGTQEVLKYLRSKIKDDGPSQSESATETAMT 386
+ + NP++ + R G ++ ++ K G + E T T
Sbjct: 284 QTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLK----GTTSLEILTLTRAG 339
Query: 387 LPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVE 446
+ + L++L+ S Q +P + + I N++ EI
Sbjct: 340 IRLLPSGMCQQLPRLRVLELSHNQIEELP----SLHRCQKLEEIGLQHNRIWEIGADTFS 395
Query: 447 LKEMVSDVDLSFNKLSFISLE-LCVLQKLTFLDLRNNFLNSLP 488
+ +DLS+N + I E L L LDL +N L +LP
Sbjct: 396 QLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLP 438
Score = 89.0 bits (219), Expect = 1e-17
Identities = 85/289 (29%), Positives = 134/289 (46%), Gaps = 42/289 (14%)
Query: 62 IPEEANQNLSFGATERWWEQTDLTKLIISNNKLQSL-TDDLRLLPALTVLDIHDNQLTSL 120
IP+ A QNL T L L + NN++Q L T L L LD++ N+L
Sbjct: 201 IPDYAFQNL-----------TSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF 249
Query: 121 PSAIRELENLQKLNVSHNKLKILPEE-ITNLRNLKCLYLQHNELTCIS-EGFEQLSNLED 178
P AIR L LQ+L +N +K +PE+ L+ ++ N + + F+ L L
Sbjct: 250 PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
Query: 179 LDLSNNHLTTVPASFSSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPE 238
L L+ +SL L L+ ++ LP S + + +P
Sbjct: 310 LSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLP---------------SGMCQQLP-- 352
Query: 239 LAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRD 298
L +L L N++ LP C L+E+ + N+I + A+ L+S+ LDL
Sbjct: 353 -----RLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSW 407
Query: 299 NKLKSV-PDEIILLRSLERLDLSNNDISSLPYS-LGNL-HLKFLALEGN 344
N ++S+ P+ L SL +LDL++N +++LP + LG L HLK L+GN
Sbjct: 408 NAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLK---LKGN 453
Score = 79.3 bits (194), Expect = 9e-15
Identities = 105/391 (26%), Positives = 164/391 (41%), Gaps = 54/391 (13%)
Query: 179 LDLSNNHLTTV-PASFSSLSSLVRLNLSSNELKSLPAE-INRMKRLKHLDCNSNLLETIP 236
LDLS N+LT + P F L L L LS N L +P + + + LK L +N L IP
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 237 PE-LAGMESLELLYLRRNKLRFLPE--FPSCSLLKELHVGENQIEMLEAEHLKHLNSILV 293
E L + SL+ L L N + +PE F S L+ L + +N + + L +L ++
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
Query: 294 LDLRDNKLKSVPDEIIL-LRSLERLDLSNNDISSL-PYSLGNLH-LKFLALEGNPLRTIR 350
+ L N++ +PD L SL L L NN I L +S LH L+ L L N L+
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Query: 351 REIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQ 410
I + G + L + + IK +P ++ + + T+ + D
Sbjct: 251 VAIRTLGRLQELGFHNNNIK---------------AIPEKAFMGNPLLQTIH---FYDNP 292
Query: 411 ATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCV 470
+ F + S+N + + + E P +LK S
Sbjct: 293 IQFVGRSAFQYLPKLHTLSLNGAMD-IQEFP----DLKGTTS------------------ 329
Query: 471 LQKLTFLDLRNNFLNSLPEEM-ESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQ 529
L L L + LP M + L RL+ + LS N+ + LP L+R LE I + +N+
Sbjct: 330 ---LEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS-LHRCQKLEEIGLQHNR 385
Query: 530 VGSVDPQKMKMMENLTTLDLQNNDLLQIPPE 560
+ + + +L LDL N + I PE
Sbjct: 386 IWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
Score = 51.6 bits (122), Expect = 2e-06
Identities = 82/318 (25%), Positives = 127/318 (39%), Gaps = 51/318 (16%)
Query: 284 HLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKFLA--- 340
H + +L D + L +VP ++ L + LDLS N+++ L L + HL+FL
Sbjct: 40 HCQEDGIMLSADCSELGLSAVPGDLDPLTAY--LDLSMNNLTELQPGLFH-HLRFLEELR 96
Query: 341 LEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIIT 400
L GN L I + S G LK L + G +E+ E LPS + + A +
Sbjct: 97 LSGNHLSHIPGQAFS-GLYS-LKILMLQNNQLGGIPAEALWE----LPSLQSLRLDANLI 150
Query: 401 LKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNK 460
+L+P+ F+ + S + + N L EIP R + + + L+ N+
Sbjct: 151 -----------SLVPERSFEGLSS--LRHLWLDDNALTEIPVRALNNLPALQAMTLALNR 197
Query: 461 LSFIS-------LELCVLQ------------------KLTFLDLRNNFLNSLPEEMESLV 495
+S I L VL L LDL N L P + +L
Sbjct: 198 ISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLG 257
Query: 496 RLQTINLSFNRFKMLPEVLYR-IFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDL 554
RLQ + N K +PE + L+TI +N + V + + L TL L
Sbjct: 258 RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMD 317
Query: 555 LQIPPELGNCVNLRTLLL 572
+Q P+L +L L L
Sbjct: 318 IQEFPDLKGTTSLEILTL 335
Score = 51.6 bits (122), Expect = 2e-06
Identities = 50/196 (25%), Positives = 85/196 (43%), Gaps = 10/196 (5%)
Query: 396 HAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVD 455
H + L+ L S + IP + F + S + + NQL IP + + +
Sbjct: 87 HHLRFLEELRLSGNHLSHIPGQAFSGLYS--LKILMLQNNQLGGIPAEALWELPSLQSLR 144
Query: 456 LSFNKLSFI---SLELCVLQKLTFLDLRNNFLNSLP-EEMESLVRLQTINLSFNRFKMLP 511
L N +S + S E L L L L +N L +P + +L LQ + L+ NR +P
Sbjct: 145 LDANLISLVPERSFE--GLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIP 202
Query: 512 EVLYRIFTLETIL-ISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTL 570
+ ++ T +L + NN++ + + + NL TLDL N L + P + L+ L
Sbjct: 203 DYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQEL 262
Query: 571 LLDGNPFR-VPRAAIL 585
N + +P A +
Sbjct: 263 GFHNNNIKAIPEKAFM 278
Score = 38.9 bits (89), Expect = 0.014
Identities = 26/93 (27%), Positives = 50/93 (53%), Gaps = 2/93 (2%)
Query: 484 LNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMEN 543
L+++P +++ L ++++ N ++ P + + + LE + +S N + + Q + +
Sbjct: 57 LSAVPGDLDPLTAYLDLSMN-NLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYS 115
Query: 544 LTTLDLQNNDLLQIPPE-LGNCVNLRTLLLDGN 575
L L LQNN L IP E L +L++L LD N
Sbjct: 116 LKILMLQNNQLGGIPAEALWELPSLQSLRLDAN 148
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 100 bits (250), Expect = 3e-21
Identities = 75/241 (31%), Positives = 136/241 (56%), Gaps = 12/241 (4%)
Query: 95 QSLTDDLRLLPALTVLDIHDNQLTSLP--SAIRELENLQKLNVSHNKLKILPEEITNLRN 152
Q +TD LLP+L L + DN+ + L + ++++ NL+ L + L+ +P I +L N
Sbjct: 554 QVVTD---LLPSLQKLSL-DNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNN 609
Query: 153 LKCLYLQHNELTCISE--GFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLSSNELK 210
L L L+ N L + E F+ L NL L L +N++ +PA +LS+L +L+L N ++
Sbjct: 610 LHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIE 669
Query: 211 SLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FPSCSLLKE 269
+LP ++ +L +LD + N L IP E+ + +L+ + N + LP+ C L+
Sbjct: 670 NLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQC 729
Query: 270 LHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLER--LDLSNNDISSL 327
L +G+N + L + H+ L+++ L+L N L+++P E+ +SL+R L + N +++L
Sbjct: 730 LLLGKNSLMNL-SPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTL 788
Query: 328 P 328
P
Sbjct: 789 P 789
Score = 93.6 bits (231), Expect = 5e-19
Identities = 58/181 (32%), Positives = 95/181 (52%), Gaps = 4/181 (2%)
Query: 83 DLTKLIISNNKLQSLTDDLRL--LPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKL 140
+L +L + N L+++ + + L L+ L + N + +P+ I L NL++L++ HN +
Sbjct: 609 NLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNI 668
Query: 141 KILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLV 200
+ LP ++ L L L +N LT I E + LSNL+ ++NN++ +P L
Sbjct: 669 ENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQ 728
Query: 201 RLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLE--LLYLRRNKLRFL 258
L L N L +L + + L HL+ N LET+PPEL G +SL+ L + N L L
Sbjct: 729 CLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTL 788
Query: 259 P 259
P
Sbjct: 789 P 789
Score = 87.8 bits (216), Expect = 3e-17
Identities = 111/446 (24%), Positives = 192/446 (43%), Gaps = 74/446 (16%)
Query: 135 VSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLED-LDLSNNHLTTVPASF 193
VS NKLK + NL +NE T + + N +D ++L L +P +
Sbjct: 391 VSENKLKQI--------NL------NNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNV 436
Query: 194 SSLSSLVRLNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGME-SLELLYLRR 252
L+ + L+L LP+ ++++ LK L + L P LA +E +L++L L+
Sbjct: 437 FELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKF 496
Query: 253 NKLRFLPEFP-SCSLLKELHVG----ENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDE 307
++ +P + LKEL++ Q+ ++ E + L ++ L L+ + L +P
Sbjct: 497 TEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS-LSRIPQV 555
Query: 308 II-LLRSLERLDLSNNDISSLPYSLGNL----HLKFLALEGNPLRTIRREIISKGTQEVL 362
+ LL SL++L L N S L NL +LK L L L I I S L
Sbjct: 556 VTDLLPSLQKLSLDNE--GSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHEL 613
Query: 363 KYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAV 422
+ +K + II+ + L
Sbjct: 614 DLRENNLK-----------------------TVEEIISFQHLQN---------------- 634
Query: 423 KSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNN 482
++ + N + IP ++ L + + L N + + L+L + KL +LDL N
Sbjct: 635 ----LSCLKLWHNNIAYIPAQIGALSNL-EQLSLDHNNIENLPLQLFLCTKLHYLDLSYN 689
Query: 483 FLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMME 542
L +PEE++ L LQ ++ N +MLP+ L++ L+ +L+ N + ++ P + +
Sbjct: 690 HLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPH-VGELS 748
Query: 543 NLTTLDLQNNDLLQIPPELGNCVNLR 568
NLT L+L N L +PPEL C +L+
Sbjct: 749 NLTHLELIGNYLETLPPELEGCQSLK 774
Score = 83.6 bits (205), Expect = 5e-16
Identities = 114/440 (25%), Positives = 178/440 (40%), Gaps = 104/440 (23%)
Query: 94 LQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKI----------- 142
L L D++ L + VL + LPSA+ +L NL++L V H+ L +
Sbjct: 429 LNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEEN 488
Query: 143 -------------LPEEITNLRNLKCLYLQHNEL-----TCISEGFEQLSNLEDLDLSNN 184
+P + +L+NLK LYL L T EGF+ L NL L L ++
Sbjct: 489 LKILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSS 548
Query: 185 HLTTVPASFSS-LSSLVRLNLSSNELKSLPA-EINRMKRLKHLDCNSNLLETIPPELAGM 242
L+ +P + L SL +L+L + K + + +M LK L+ S LE IP + +
Sbjct: 549 -LSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSL 607
Query: 243 ESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLK 302
+L L LR N L+ + E S +HL ++ L L N +
Sbjct: 608 NNLHELDLRENNLKTVEEIIS---------------------FQHLQNLSCLKLWHNNIA 646
Query: 303 SVPDEIILLRSLERLDLSNNDISSLPYSLG-NLHLKFLALEGNPLRTIRREIISKGTQEV 361
+P +I L +LE+L L +N+I +LP L L +L L N L I EI
Sbjct: 647 YIPAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEI-------- 698
Query: 362 LKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDA 421
+YL + L+ ++ ++PD +F
Sbjct: 699 -QYLSN---------------------------------LQYFAVTNNNIEMLPDGLFQC 724
Query: 422 VKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFI--SLELCVLQKLTFLDL 479
K + + KN L + + EL + + ++L N L + LE C K L +
Sbjct: 725 KK---LQCLLLGKNSLMNLSPHVGELSNL-THLELIGNYLETLPPELEGCQSLKRNCLIV 780
Query: 480 RNNFLNSLPEEMESLVRLQT 499
N LN+LP + RLQT
Sbjct: 781 EENLLNTLP--LPVTERLQT 798
Score = 78.2 bits (191), Expect = 2e-14
Identities = 47/137 (34%), Positives = 75/137 (54%), Gaps = 2/137 (1%)
Query: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
++L +L + +N +++L L L L LD+ N LT +P I+ L NLQ V++N ++
Sbjct: 656 SNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIE 715
Query: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
+LP+ + + L+CL L N L +S +LSNL L+L N+L T+P SL R
Sbjct: 716 MLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKR 775
Query: 202 --LNLSSNELKSLPAEI 216
L + N L +LP +
Sbjct: 776 NCLIVEENLLNTLPLPV 792
Score = 58.5 bits (140), Expect = 2e-08
Identities = 91/364 (25%), Positives = 161/364 (44%), Gaps = 43/364 (11%)
Query: 248 LYLRRNKLRFLPEFPSCSLLKELHVG-ENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPD 306
LY +R + FL E S + LK++++ E +E L+++ +K+ + L L L +PD
Sbjct: 379 LYSKRFSI-FLSEV-SENKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLF--MLNGLPD 434
Query: 307 EIILLRSLERLDLSNNDISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYL 365
+ L +E L L LP ++ L +LK L + + L + +E LK L
Sbjct: 435 NVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAF--LEENLKIL 492
Query: 366 RSKIKDDGP--------SQSESATETAMTLPSE-SRVNIHAIITLKILD--YSDKQATLI 414
R K + G + + LP + S + + LK L Y + I
Sbjct: 493 RLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRI 552
Query: 415 PDEVFDAVKSNIVTSINFSKNQLCEIP--KRMVELK--EMVS-----------------D 453
P V D + S S++ ++L + K+MV LK E++S +
Sbjct: 553 PQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHE 612
Query: 454 VDLSFNKLSFIS--LELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLP 511
+DL N L + + LQ L+ L L +N + +P ++ +L L+ ++L N + LP
Sbjct: 613 LDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIENLP 672
Query: 512 EVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLL 571
L+ L + +S N + + P++++ + NL + NN++ +P L C L+ LL
Sbjct: 673 LQLFLCTKLHYLDLSYNHLTFI-PEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
Query: 572 LDGN 575
L N
Sbjct: 732 LGKN 735
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.374
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,586,393
Number of Sequences: 37866
Number of extensions: 865966
Number of successful extensions: 7285
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 182
Number of HSP's successfully gapped in prelim test: 167
Number of HSP's that attempted gapping in prelim test: 2619
Number of HSP's gapped (non-prelim): 1736
length of query: 602
length of database: 18,247,518
effective HSP length: 108
effective length of query: 494
effective length of database: 14,157,990
effective search space: 6994047060
effective search space used: 6994047060
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.