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Search of human proteins with 11386137
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
(908 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 1825 0.0
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 1719 0.0
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 1483 0.0
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 1438 0.0
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 1409 0.0
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 725 0.0
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 705 0.0
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 623 e-178
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 622 e-178
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 615 e-176
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 614 e-175
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 611 e-175
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 611 e-174
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 609 e-174
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 593 e-169
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 586 e-167
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 362 1e-99
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 357 3e-98
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 258 1e-68
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 257 3e-68
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 257 3e-68
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 192 1e-48
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 188 2e-47
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 188 2e-47
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 188 2e-47
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 174 3e-43
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 171 4e-42
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 159 1e-38
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 157 3e-38
gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3 p... 135 2e-31
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 1825 bits (4727), Expect = 0.0
Identities = 908/908 (100%), Positives = 908/908 (100%)
Query: 1 MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA 60
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
Sbjct: 1 MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA 60
Query: 61 VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS 120
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
Sbjct: 61 VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS 120
Query: 121 ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST 180
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
Sbjct: 121 ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST 180
Query: 181 GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
Sbjct: 181 GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240
Query: 241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER 300
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
Sbjct: 241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER 300
Query: 301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM 360
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
Sbjct: 301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM 360
Query: 361 SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK 420
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
Sbjct: 361 SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK 420
Query: 421 PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI 480
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
Sbjct: 421 PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI 480
Query: 481 RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI 540
RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
Sbjct: 481 RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI 540
Query: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 600
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
Sbjct: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 600
Query: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
Sbjct: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660
Query: 661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
Sbjct: 661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720
Query: 721 NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI 780
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
Sbjct: 721 NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI 780
Query: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
Sbjct: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840
Query: 841 EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR 900
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
Sbjct: 841 EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR 900
Query: 901 LPGKETMA 908
LPGKETMA
Sbjct: 901 LPGKETMA 908
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 1719 bits (4451), Expect = 0.0
Identities = 855/856 (99%), Positives = 855/856 (99%)
Query: 1 MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA 60
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
Sbjct: 1 MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA 60
Query: 61 VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS 120
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
Sbjct: 61 VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS 120
Query: 121 ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST 180
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
Sbjct: 121 ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST 180
Query: 181 GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
Sbjct: 181 GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK 240
Query: 241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER 300
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
Sbjct: 241 QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER 300
Query: 301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM 360
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
Sbjct: 301 LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM 360
Query: 361 SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK 420
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
Sbjct: 361 SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK 420
Query: 421 PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI 480
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
Sbjct: 421 PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI 480
Query: 481 RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI 540
RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
Sbjct: 481 RLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI 540
Query: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 600
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
Sbjct: 541 LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD 600
Query: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
Sbjct: 601 VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT 660
Query: 661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
Sbjct: 661 VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS 720
Query: 721 NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI 780
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
Sbjct: 721 NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI 780
Query: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
Sbjct: 781 AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG 840
Query: 841 EFLYKSKKNAQLEKRS 856
EFLYKSKKNAQLEK S
Sbjct: 841 EFLYKSKKNAQLEKES 856
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 1483 bits (3840), Expect = 0.0
Identities = 719/894 (80%), Positives = 808/894 (90%), Gaps = 7/894 (0%)
Query: 19 LLLCLLWIGYSQGTTHVLRFGGIFEYVESGP----MGAEELAFRFAVNTINRNRTLLPNT 74
LL+C WI S+G HV+R GGIFEY + GP M AEE AFRF+ N INRNRTLLPNT
Sbjct: 19 LLVCAFWIPDSRGMPHVIRIGGIFEYAD-GPNAQVMNAEEHAFRFSANIINRNRTLLPNT 77
Query: 75 TLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW 134
TLTYD Q+I+ +DSFEA+KKACDQL+LGV AIFGPS S NAVQSICNAL VPHIQ RW
Sbjct: 78 TLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRW 137
Query: 135 KHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSR 194
KH DNKD+FYV+LYPD++SLS AILDLVQ+ KW++ TVVYDDSTGLIRLQELI APSR
Sbjct: 138 KHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSR 197
Query: 195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHY 254
YN+RLKIRQLP D+ D++PLLKEMKRG+EF +IFDCSH MAA ILKQA+AMGMMTEYYH+
Sbjct: 198 YNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHF 257
Query: 255 IFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDG 314
IFTTLDL+ALD+EPYRYSGVN+TGFRILN +N VS+I+EKWSMERLQA P+ +SGLLDG
Sbjct: 258 IFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDG 317
Query: 315 FMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGR 374
M TDAAL+YDAVH+VSV Q+ PQMTV+SLQC+RHK WRFG RFM+ IKEA WEGLTGR
Sbjct: 318 VMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGR 377
Query: 375 ITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLI 434
I FNKT+GLRTDFDLD+ISLKE+GLEK+G W PA GLN+TE KG+ N+TDSL+NRSLI
Sbjct: 378 IVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLI 437
Query: 435 VTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDA 494
VTT+LEEP+V+F+KSD+ LYGNDRFEGYCIDLL+EL+ ILGF+YEIRLVEDGKYGAQDD
Sbjct: 438 VTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDD- 496
Query: 495 NGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFS 554
GQWNGMV+ELIDHKADLAVAPL IT+VREK IDFSKPFMTLG+SILYRKPNGTNP VFS
Sbjct: 497 KGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFS 556
Query: 555 FLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWF 614
FLNPLSPDIWMY+LLAYLGVSCVLFVIARFSPYEWY+ HPCNP S+VVENNFTLLNSFWF
Sbjct: 557 FLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWF 616
Query: 615 GVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 674
G+G+LMQQGSELMPKALSTRI+GGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL
Sbjct: 617 GMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDL 676
Query: 675 AKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYA 734
AKQTKIEYGAV+DGATMTFFKKSKIST++KMWAFMSS + S LVK+NEEGIQR LT+DYA
Sbjct: 677 AKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSS-KPSALVKNNEEGIQRALTADYA 735
Query: 735 FLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMM 794
LMESTTIE+VTQRNCNLTQIGGLIDSKGYG+GTPMGSPYRDKITIAILQLQEE KLH+M
Sbjct: 736 LLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIM 795
Query: 795 KEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
KEKWWRG+GCPEEE+KEASALG+Q IGGIFIVLAAGLVLSV VAVGEF+YK +K A+ E+
Sbjct: 796 KEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQ 855
Query: 855 RSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA 908
RSFCS + +E+R SL CQRR+KHKPQ P++VKT+ VINMHTFNDRRLPGK++MA
Sbjct: 856 RSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMA 909
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 1438 bits (3722), Expect = 0.0
Identities = 705/895 (78%), Positives = 799/895 (89%), Gaps = 4/895 (0%)
Query: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
R T LL L Q VLR GGIFE VE+ P+ EELAF+FAV +INRNRTL+PN
Sbjct: 15 RDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPN 74
Query: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTR 133
TTLTYD Q+INL+DSFEAS++ACDQL+LGVAA+FGPSHSSS +AVQSICNAL VPHIQTR
Sbjct: 75 TTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTR 134
Query: 134 WKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPS 193
WKH DNKD FY++LYPD++++SRAILDLV ++ WKTVTVVY+DSTGLIRLQELIKAPS
Sbjct: 135 WKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPS 194
Query: 194 RYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
RYN+++KIRQLP+ KDAKPLLKEMK+GKEF+VIFDCSHE AA ILKQ L MGMMTEYYH
Sbjct: 195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH 254
Query: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
Y FTTLDLFALD+E YRYSGVNMTGFR+LN +N VSSIIEKWSMERLQAPP+P++GLLD
Sbjct: 255 YFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314
Query: 314 GFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG 373
G MTT+AALMYDAV++V++A + Q+TVSSLQC+RHKPWR G RFM+LIKEA W+GLTG
Sbjct: 315 GMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
Query: 374 RITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSL 433
ITFNKTNGLR DFDLD+ISLKEEG EKIG W+ SGLNMT+S K K +NITDSL+NR+L
Sbjct: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRTL 434
Query: 434 IVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDD 493
IVTTILEEPYV+++KSDKPLYGNDRFEGYC+DLL+ELS ILGF Y+++LV DGKYGAQ+D
Sbjct: 435 IVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIYDVKLVPDGKYGAQND 494
Query: 494 ANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
G+WNGMV+ELIDH+ADLAVAPL ITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF
Sbjct: 495 -KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVF 553
Query: 554 SFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
SFLNPLSPDIWMY+LLA LGVSCVLFVIARF+PYEWYNPHPCNPDSDVVENNFTLLNSFW
Sbjct: 554 SFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFW 613
Query: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD
Sbjct: 614 FGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673
Query: 674 LAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY 733
LAKQTKIEYGAV DG+TMTFFKKSKISTY+KMWAFMSSR+Q+ LV++++EGIQRVLT+DY
Sbjct: 674 LAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY 733
Query: 734 AFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHM 793
A LMEST+IE+VTQRNCNLTQIGGLIDSKGYGVGTP+GSPYRDKITIAILQLQEEGKLHM
Sbjct: 734 ALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHM 793
Query: 794 MKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLE 853
MKEKWWRGNGCPEE++KEASALGV+NIGGIFIVLAAGLVLSVFVA+GEF+YKS+KN +E
Sbjct: 794 MKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIYKSRKNNDIE 853
Query: 854 KRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA 908
+ +A++EEL +SLK Q+++K K + ++ H RR KET+A
Sbjct: 854 QCLSFNAIMEELGISLKNQKKIKKKSRTKGKSSFTSILTCH---QRRTQRKETVA 905
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 1409 bits (3647), Expect = 0.0
Identities = 690/860 (80%), Positives = 774/860 (90%), Gaps = 17/860 (1%)
Query: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
R T LL L Q VLR GGIFE VE+ P+ EELAF+FAV +INRNRTL+PN
Sbjct: 15 RDTSWALLYFLCYILPQTAPQVLRIGGIFETVENEPVNVEELAFKFAVTSINRNRTLMPN 74
Query: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTR 133
TTLTYD Q+INL+DSFEAS++ACDQL+LGVAA+FGPSHSSS +AVQSICNAL VPHIQTR
Sbjct: 75 TTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQSICNALEVPHIQTR 134
Query: 134 WKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPS 193
WKH DNKD FY++LYPD++++SRAILDLV ++ WKTVTVVY+DSTGLIRLQELIKAPS
Sbjct: 135 WKHPSVDNKDLFYINLYPDYAAISRAILDLVLYYNWKTVTVVYEDSTGLIRLQELIKAPS 194
Query: 194 RYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
RYN+++KIRQLP+ KDAKPLLKEMK+GKEF+VIFDCSHE AA ILKQ L MGMMTEYYH
Sbjct: 195 RYNIKIKIRQLPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYH 254
Query: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLD 313
Y FTTLDLFALD+E YRYSGVNMTGFR+LN +N VSSIIEKWSMERLQAPP+P++GLLD
Sbjct: 255 YFFTTLDLFALDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLD 314
Query: 314 GFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTG 373
G MTT+AALMYDAV++V++A + Q+TVSSLQC+RHKPWR G RFM+LIKEA W+GLTG
Sbjct: 315 GMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTG 374
Query: 374 RITFNKTNGLRTDFDLDVISLKEEGLEK---------------IGTWDPASGLNMTESQK 418
ITFNKTNGLR DFDLD+ISLKEEG EK IG W+ SGLNMT+S K
Sbjct: 375 HITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYKVWKKIGIWNSNSGLNMTDSNK 434
Query: 419 GKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTY 478
K +NITDSL+NR+LIVTTILEEPYV+++KSDKPLYGNDRFEGYC+DLL+ELS ILGF Y
Sbjct: 435 DKSSNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEGYCLDLLKELSNILGFIY 494
Query: 479 EIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGI 538
+++LV DGKYGAQ+D G+WNGMV+ELIDH+ADLAVAPL ITYVREKVIDFSKPFMTLGI
Sbjct: 495 DVKLVPDGKYGAQND-KGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGI 553
Query: 539 SILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPD 598
SILYRKPNGTNPGVFSFLNPLSPDIWMY+LLA LGVSCVLFVIARF+PYEWYNPHPCNPD
Sbjct: 554 SILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPD 613
Query: 599 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 658
SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF
Sbjct: 614 SDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAF 673
Query: 659 LTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLV 718
LTVERMESPIDSADDLAKQTKIEYGAV DG+TMTFFKKSKISTY+KMWAFMSSR+Q+ LV
Sbjct: 674 LTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALV 733
Query: 719 KSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKI 778
++++EGIQRVLT+DYA LMEST+IE+VTQRNCNLTQIGGLIDSKGYGVGTP+GSPYRDKI
Sbjct: 734 RNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYGVGTPIGSPYRDKI 793
Query: 779 TIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVA 838
TIAILQLQEEGKLHMMKEKWWRGNGCPEE++KEASALGV+NIGGIFIVLAAGLVLSVFVA
Sbjct: 794 TIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVA 853
Query: 839 VGEFLYKSKKNAQLEKRSFC 858
+GEF+YKS+KN +E ++FC
Sbjct: 854 IGEFIYKSRKNNDIE-QAFC 872
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 725 bits (1871), Expect = 0.0
Identities = 399/879 (45%), Positives = 552/879 (62%), Gaps = 29/879 (3%)
Query: 20 LLCLLWIGYSQGTTHVL---RFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTL 76
LL LL + ++ + VL R I + G E LA A IN + +
Sbjct: 5 LLLLLIVAFASPSCQVLSSLRMAAILDDQTVCGRG-ERLALALAREQINGIIEVPAKARV 63
Query: 77 TYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHS-SSANAVQSICNALGVPHIQTRWK 135
D ++ +E + C L GV ++ GPS S +SA+ V IC +PHI+ +
Sbjct: 64 EVDIFELQRDSQYETTDTMCQILPKGVVSVLGPSSSPASASTVSHICGEKEIPHIKVGPE 123
Query: 136 HQVSDNKDSFY-VSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSR 194
F VSLYP +S A+ +++ F + + +++ + L+RL+EL++
Sbjct: 124 ETPRLQYLRFASVSLYPSNEDVSLAVSRILKSFNYPSASLICAKAECLLRLEELVRGFLI 183
Query: 195 YNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHY 254
L +R L D++D PLLKE++ K +I D + ++ IL++A +GM + +Y Y
Sbjct: 184 SKETLSVRMLD-DSRDPTPLLKEIRDDKVSTIIIDANASISHLILRKASELGMTSAFYKY 242
Query: 255 IFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSM---ERLQAPPKPDSGL 311
I TT+D L ++ N+ GF + NT + + +M E +A L
Sbjct: 243 ILTTMDFPILHLDGIVEDSSNILGFSMFNTSHPFYPEFVRSLNMSWRENCEASTYLGPAL 302
Query: 312 LDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIKEAHW 368
AALM+DAVHVV AV++ ++ V L C W GT M+ ++ +
Sbjct: 303 -------SAALMFDAVHVVVSAVRELNRSQEIGVKPLACTSANIWPHGTSLMNYLRMVEY 355
Query: 369 EGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSL 428
+GLTGR+ FN + G RT++ L ++ +G +IG W L M + N++ +L
Sbjct: 356 DGLTGRVEFN-SKGQRTNYTLRILEKSRQGHREIGVWYSNRTLAMNATTLD--INLSQTL 412
Query: 429 SNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKY 488
+N++L+VTTILE PYV+ + + + L GN+RFEG+C+D+LREL+ +L F Y +RLVEDG Y
Sbjct: 413 ANKTLVVTTILENPYVMRRPNFQALSGNERFEGFCVDMLRELAELLRFRYRLRLVEDGLY 472
Query: 489 GAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT 548
GA + NG W GMV ELI+ KADLAVA IT REKVIDFSKPFMTLGISILYR G
Sbjct: 473 GAPEP-NGSWTGMVGELINRKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGR 531
Query: 549 NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPC-NPDSDVVENNFT 607
PG FSFL+P SP +W+++LLAYL VSCVLF+ AR SPYEWYNPHPC ++EN +T
Sbjct: 532 KPGYFSFLDPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYT 591
Query: 608 LLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESP 667
L NS WF VG MQQGSE+MP+ALSTR V G+WW FTLIIISSYTANLAAFLTV+RME P
Sbjct: 592 LGNSLWFPVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVP 651
Query: 668 IDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQR 727
++SADDLA QT IEYG + G+TMTFF+ S+ TY +MW +M S++ SV VKS EEGI R
Sbjct: 652 VESADDLADQTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIAR 711
Query: 728 VLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQE 787
VL S YAFL+EST E+ + NCNLTQIGGL+D+KGYG+G P+GSP+RD+IT+AILQLQE
Sbjct: 712 VLNSRYAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQE 771
Query: 788 EGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSK 847
+L ++K KWW G CP+EE A LG++NIGGIFIVL GL+++VFVAV EF++ ++
Sbjct: 772 NNRLEILKRKWWEGGRCPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVMEFIWSTR 831
Query: 848 KNAQLEKRSFCSAMVEELRMSLKCQR----RLKHKPQAP 882
++A+ E+ S C M++ELR ++ C++ R + +P P
Sbjct: 832 RSAESEEVSVCQEMLQELRHAVSCRKTSRSRRRRRPGGP 870
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 705 bits (1819), Expect = 0.0
Identities = 395/907 (43%), Positives = 551/907 (60%), Gaps = 32/907 (3%)
Query: 14 RRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPN 73
R + L+L W+ + H LR I + G E L+ A N INR L
Sbjct: 3 RVSAPLVLLPAWLVMVACSPHSLRIAAILDDPMECSRG-ERLSITLAKNRINRAPERLGK 61
Query: 74 TTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHS-SSANAVQSICNALGVPHIQT 132
+ D ++ +E ++ C L GV A+ GPS S +S++ + +IC VPH +
Sbjct: 62 AKVEVDIFELLRDSEYETAETMCQILPKGVVAVLGPSSSPASSSIISNICGEKEVPHFKV 121
Query: 133 RWKHQVSDNKDSFY-VSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKA 191
+ V F ++L+P + +S A+ ++ FF T ++ + L+ L++L++
Sbjct: 122 APEEFVKFQFQRFTTLNLHPSNTDISVAVAGILNFFNCTTACLICAKAECLLNLEKLLRQ 181
Query: 192 PSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEY 251
L +R L DT+D PLLKE++ K +I + M+ IL +A +GM++ Y
Sbjct: 182 FLISKDTLSVRMLD-DTRDPTPLLKEIRDDKTATIIIHANASMSHTILLKAAELGMVSAY 240
Query: 252 YHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQ----VSSIIEKWSMERLQAPPKP 307
Y YIFT L+ ++ VN+ GF I N + S+ + W E P
Sbjct: 241 YTYIFTNLEFSLQRMDSLVDDRVNILGFSIFNQSHAFFQEFAQSLNQSWQ-ENCDHVPFT 299
Query: 308 DSGLLDGFMTTDAALMYDAVHVVSVAVQQF---PQMTVSSLQCNRHKPWRFGTRFMSLIK 364
L +AL++DAV+ V AVQ+ ++ V L C + W+ GT M+ ++
Sbjct: 300 GPAL-------SSALLFDAVYAVVTAVQELNRSQEIGVKPLSCGSAQIWQHGTSLMNYLR 352
Query: 365 EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANI 424
EGLTG I FN + G R+++ L ++ G +IG W A GL+M +NI
Sbjct: 353 MVELEGLTGHIEFN-SKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYA--SNI 409
Query: 425 TDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVE 484
+D+L N +L+VTTILE PY++ K + + + GNDR+EG+C+D+L+EL+ IL F Y+IRLV
Sbjct: 410 SDTLFNTTLVVTTILENPYLMLKGNHQEMEGNDRYEGFCVDMLKELAEILRFNYKIRLVG 469
Query: 485 DGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544
DG YG + ANG W GMV ELI KADLAVA L IT REKVIDFSKPFMTLGISILYR
Sbjct: 470 DGVYGVPE-ANGTWTGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRV 528
Query: 545 PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDS-DVVE 603
G PG FSFL+P SP +W+++LLAYL VSCVLF++AR +PYEWY+PHPC +++
Sbjct: 529 HMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLV 588
Query: 604 NNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVER 663
N ++L NS WF VG MQQGS + P+ALSTR V G+WW FTLIIISSYTANLAAFLTV+R
Sbjct: 589 NQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQR 648
Query: 664 MESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEE 723
M+ PI+S DDLA QT IEYG + G++MTFF+ S+ TY +MW +M S++ SV VKS EE
Sbjct: 649 MDVPIESVDDLADQTAIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEE 708
Query: 724 GIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAIL 783
GI RVL S+YAFL+EST E+ QRNCNLTQIGGL+D+KGYG+G P+GS +RD+ +AIL
Sbjct: 709 GIARVLNSNYAFLLESTMNEYYRQRNCNLTQIGGLLDTKGYGIGMPVGSVFRDEFDLAIL 768
Query: 784 QLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843
QLQE +L ++K KWW G CP+EE A LG++NIGGIF+VL GL++++F+A+ EFL
Sbjct: 769 QLQENNRLEILKRKWWEGGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLEFL 828
Query: 844 YKSKKNAQLEKRSFCSAMVEELRMSLKCQ-------RRLKHKPQAPVIVKTEEVINMHTF 896
+ + ++++ + S C MV ELR + CQ RR P P I + T
Sbjct: 829 W-TLRHSEATEVSVCQEMVTELRSIILCQDSIHPRRRRAAVPPPRPPIPEERRPRGTATL 887
Query: 897 NDRRLPG 903
++ +L G
Sbjct: 888 SNGKLCG 894
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 623 bits (1607), Expect = e-178
Identities = 347/848 (40%), Positives = 512/848 (60%), Gaps = 54/848 (6%)
Query: 36 LRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKA 95
++ GG+F +S E AFRFA++ + LLP + +N+ DSFE + +
Sbjct: 25 IQIGGLFPNQQS----QEHAAFRFALSQLTEPPKLLPQIDI------VNISDSFEMTYRF 74
Query: 96 CDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSS 155
C Q S GV AIFG + N + S C AL V I + D + F + L P+
Sbjct: 75 CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP---VDTSNQFVLQLRPE--- 128
Query: 156 LSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDA-KPL 214
L A++ ++ +KW+ +YD GL LQ+++ + N ++ + T++ + L
Sbjct: 129 LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRML 188
Query: 215 LKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGV 274
+++++ KE V+ DC E IL Q + + YHYI L +D+ ++ SG
Sbjct: 189 FQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGA 248
Query: 275 NMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAV 334
N+TGF+++N +T + I+++W + + D +AL YD V V++ A
Sbjct: 249 NVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKR----PKYTSALTYDGVKVMAEAF 304
Query: 335 QQFPQMTVSSLQ--------CNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTD 386
Q + + + N PW G +++ +EGLTG + FN+ G RT+
Sbjct: 305 QSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNE-KGRRTN 363
Query: 387 FDLDVISLKEEGLEKIGTWD------PASGLNMTESQKGKPANITDSLSNRSLIVTTILE 440
+ L VI +K +G+ KIG W+ PA+ T++Q G S+ NR+ IVTTILE
Sbjct: 364 YTLHVIEMKHDGIRKIGYWNEDDKFVPAA----TDAQAGGD---NSSVQNRTYIVTTILE 416
Query: 441 EPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNG 500
+PYV+ KK+ GNDR+EGYC++L E++ +G++Y + +V DGKYGA+D WNG
Sbjct: 417 DPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNG 476
Query: 501 MVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLS 560
MV EL+ +AD+AVAPL IT VRE+VIDFSKPFM+LGISI+ +KP + PGVFSFL+PL+
Sbjct: 477 MVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 536
Query: 561 PDIWMYILLAYLGVSCVLFVIARFSPYEWYN---PHPCNPDSDVVENNFTLLNSFWFGVG 617
+IWM I+ AY+GVS VLF+++RFSPYEW++ + + N F + NS WF +G
Sbjct: 537 YEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLG 596
Query: 618 ALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ 677
A MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DLAKQ
Sbjct: 597 AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 656
Query: 678 TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAF 735
T+I YG +E G+T FF++SKI+ ++KMW +M S SV V++ EEG+ RV S YA+
Sbjct: 657 TEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAY 716
Query: 736 LMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMM 794
L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R + +A+L+L E+G L +
Sbjct: 717 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKL 776
Query: 795 KEKWWRGNG-CPEEES---KEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNA 850
K KWW G C ++S + SAL + N+ G+F +L GL L++ VA+ EF YKS+ +
Sbjct: 777 KSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSES 836
Query: 851 QLEKRSFC 858
+ + FC
Sbjct: 837 K-RMKGFC 843
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 622 bits (1604), Expect = e-178
Identities = 346/848 (40%), Positives = 511/848 (60%), Gaps = 54/848 (6%)
Query: 36 LRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKA 95
++ GG+F +S E AFRFA++ + LLP + +N+ DSFE + +
Sbjct: 25 IQIGGLFPNQQS----QEHAAFRFALSQLTEPPKLLPQIDI------VNISDSFEMTYRF 74
Query: 96 CDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSS 155
C Q S GV AIFG + N + S C AL V I + D + F + L P+
Sbjct: 75 CSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFP---VDTSNQFVLQLRPE--- 128
Query: 156 LSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDA-KPL 214
L A++ ++ +KW+ +YD GL LQ+++ + N ++ + T++ + L
Sbjct: 129 LQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKNWQVTAVNILTTTEEGYRML 188
Query: 215 LKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGV 274
+++++ KE V+ DC E IL Q + + YHYI L +D+ ++ SG
Sbjct: 189 FQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYILANLGFMDIDLNKFKESGA 248
Query: 275 NMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAV 334
N+TGF+++N +T + I+++W + + D +AL YD V V++ A
Sbjct: 249 NVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKR----PKYTSALTYDGVKVMAEAF 304
Query: 335 QQFPQMTVSSLQ--------CNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTD 386
Q + + + N PW G +++ +EGLTG + FN+ G RT+
Sbjct: 305 QSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNE-KGRRTN 363
Query: 387 FDLDVISLKEEGLEKIGTWD------PASGLNMTESQKGKPANITDSLSNRSLIVTTILE 440
+ L VI +K +G+ KIG W+ PA+ T++Q G S+ NR+ IVTTILE
Sbjct: 364 YTLHVIEMKHDGIRKIGYWNEDDKFVPAA----TDAQAGGD---NSSVQNRTYIVTTILE 416
Query: 441 EPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNG 500
+PYV+ KK+ GNDR+EGYC++L E++ +G++Y + +V DGKYGA+D WNG
Sbjct: 417 DPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNG 476
Query: 501 MVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLS 560
MV EL+ +AD+AVAPL IT VRE+VIDFSKPFM+LGISI+ +KP + PGVFSFL+PL+
Sbjct: 477 MVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLA 536
Query: 561 PDIWMYILLAYLGVSCVLFVIARFSPYEWYN---PHPCNPDSDVVENNFTLLNSFWFGVG 617
+IWM I+ AY+GVS VLF+++RFSPYEW++ + + N F + NS WF +G
Sbjct: 537 YEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLG 596
Query: 618 ALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ 677
A MQQG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFLTVERM SPI+SA+DLAKQ
Sbjct: 597 AFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ 656
Query: 678 TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTS--DYAF 735
T+I YG +E G+T FF++SKI+ ++KMW +M S SV V++ EEG+ RV S YA+
Sbjct: 657 TEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAY 716
Query: 736 LMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMM 794
L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+ + +A+L+L E+G L +
Sbjct: 717 LLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKL 776
Query: 795 KEKWWRGNG-CPE---EESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNA 850
K KWW G C + + SAL + N+ G+F +L GL L++ VA+ EF YKS+ +
Sbjct: 777 KNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSES 836
Query: 851 QLEKRSFC 858
+ + FC
Sbjct: 837 K-RMKGFC 843
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 615 bits (1585), Expect = e-176
Identities = 346/862 (40%), Positives = 511/862 (59%), Gaps = 50/862 (5%)
Query: 19 LLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTY 78
LL +LW +++ ++ GG+F P GA++ F V + + + LT
Sbjct: 10 LLSPVLWGLIFGVSSNSIQIGGLF------PRGADQEYSAFRVGMVQFSTS---EFRLTP 60
Query: 79 DTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQV 138
+ + +SF + C Q S GV AIFG S N + S C L V I +
Sbjct: 61 HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP--- 117
Query: 139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR 198
+D F + + PD L A+L L+++++W +YD GL LQ ++ + + +
Sbjct: 118 TDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQ 174
Query: 199 ---LKIRQLPADTKDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
+ + + D KD + L ++++ KE VI DC + I+ Q + +G + YH
Sbjct: 175 VTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYH 234
Query: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDSGLL 312
YI L D+ ++ G N++GF+I++ +++ VS IE+WS +E + P G
Sbjct: 235 YIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP-----GAH 289
Query: 313 DGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFGTRFMSLIK 364
+ +AL YDAV V++ A + + + + N PW G +K
Sbjct: 290 TTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALK 349
Query: 365 EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL--NMTESQKGKPA 422
+ EGL+G I F++ NG R ++ ++++ LK G KIG W + +TE G
Sbjct: 350 QVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG--- 405
Query: 423 NITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRL 482
N T L N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ +
Sbjct: 406 NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTI 465
Query: 483 VEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY 542
V DGKYGA+D WNGMV EL+ KAD+A+APL IT VRE+VIDFSKPFM+LGISI+
Sbjct: 466 VGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI 525
Query: 543 RKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH---PCNPDS 599
+KP + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+ S
Sbjct: 526 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQS 585
Query: 600 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFL 659
N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFL
Sbjct: 586 SESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645
Query: 660 TVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVK 719
TVERM SPI+SA+DL+KQT+I YG ++ G+T FF++SKI+ +DKMW +M S SV V+
Sbjct: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705
Query: 720 SNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRD 776
+ EG+ RV S YA+L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R
Sbjct: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRT 765
Query: 777 KITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQNIGGIFIVLAAGLV 832
+ +A+L+L E+G L +K KWW G C ++S ++ SAL + N+ G+F +L GL
Sbjct: 766 PVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVGGLG 825
Query: 833 LSVFVAVGEFLYKSKKNAQLEK 854
L++ VA+ EF YKS+ A+ K
Sbjct: 826 LAMLVALIEFCYKSRAEAKRMK 847
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 614 bits (1583), Expect = e-175
Identities = 345/862 (40%), Positives = 510/862 (59%), Gaps = 50/862 (5%)
Query: 19 LLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTY 78
LL +LW +++ ++ GG+F P GA++ F V + + + LT
Sbjct: 10 LLSPVLWGLIFGVSSNSIQIGGLF------PRGADQEYSAFRVGMVQFSTS---EFRLTP 60
Query: 79 DTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQV 138
+ + +SF + C Q S GV AIFG S N + S C L V I +
Sbjct: 61 HIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP--- 117
Query: 139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR 198
+D F + + PD L A+L L+++++W +YD GL LQ ++ + + +
Sbjct: 118 TDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQ 174
Query: 199 ---LKIRQLPADTKDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYH 253
+ + + D KD + L ++++ KE VI DC + I+ Q + +G + YH
Sbjct: 175 VTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYH 234
Query: 254 YIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDSGLL 312
YI L D+ ++ G N++GF+I++ +++ VS IE+WS +E + P G
Sbjct: 235 YIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP-----GAH 289
Query: 313 DGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFGTRFMSLIK 364
+ +AL YDAV V++ A + + + + N PW G +K
Sbjct: 290 TTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALK 349
Query: 365 EAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL--NMTESQKGKPA 422
+ EGL+G I F++ NG R ++ ++++ LK G KIG W + +TE G
Sbjct: 350 QVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG--- 405
Query: 423 NITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRL 482
N T L N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y++ +
Sbjct: 406 NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTI 465
Query: 483 VEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILY 542
V DGKYGA+D WNGMV EL+ KAD+A+APL IT VRE+VIDFSKPFM+LGISI+
Sbjct: 466 VGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMI 525
Query: 543 RKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH---PCNPDS 599
+KP + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+ S
Sbjct: 526 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQS 585
Query: 600 DVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFL 659
N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLAAFL
Sbjct: 586 SESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFL 645
Query: 660 TVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVK 719
TVERM SPI+SA+DL+KQT+I YG ++ G+T FF++SKI+ +DKMW +M S SV V+
Sbjct: 646 TVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVR 705
Query: 720 SNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSPYRD 776
+ EG+ RV S YA+L+EST E++ QR C+ ++GG +DSKGYG+ TP GS R+
Sbjct: 706 TTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLRN 765
Query: 777 KITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EESKEASALGVQNIGGIFIVLAAGLV 832
+ +A+L+L E+G L +K KWW G C + ++ SAL + N+ G+F +L GL
Sbjct: 766 AVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLG 825
Query: 833 LSVFVAVGEFLYKSKKNAQLEK 854
L++ VA+ EF YKS+ A+ K
Sbjct: 826 LAMLVALIEFCYKSRAEAKRMK 847
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 611 bits (1576), Expect = e-175
Identities = 359/875 (41%), Positives = 517/875 (59%), Gaps = 51/875 (5%)
Query: 8 LSNPVFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINR 66
+ V R L+L LL G+S G + + GG+F E AFRFAV N
Sbjct: 7 MGQSVLRAVFFLVLGLL--GHSHGGFPNTISIGGLF----MRNTVQEHSAFRFAVQLYNT 60
Query: 67 NRTLLPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSI 121
N+ NTT L Y ++ +SF + C Q S GV AIFG S N + S
Sbjct: 61 NQ----NTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSF 116
Query: 122 CNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTG 181
C AL + + +D F + + P +L AIL L+ +KW+ +YD G
Sbjct: 117 CGALHTSFVTPSFP---TDADVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERG 170
Query: 182 LIRLQELIKAPSRYNLRLKIRQLP--ADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGIL 239
LQ +++A + N ++ R + D ++ + +++EM R +E + DC E IL
Sbjct: 171 FSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTIL 230
Query: 240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSME 299
+Q + +G + YHY+ L + +E + G N+TGF+I+N EN V I++W
Sbjct: 231 EQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV-- 288
Query: 300 RLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTV------SSLQC--NRHK 351
RL P++ + + +AL +DA+ V++ A + + V S+ C N
Sbjct: 289 RLDEREFPEAK--NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAV 346
Query: 352 PWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL 411
PW G +K +G+TG I F+ T G RT++ +DV +K G K G W+
Sbjct: 347 PWSQGIDIERALKMVQVQGMTGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYERF 405
Query: 412 NMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELS 471
Q+ +N + S NR+++VTTILE PYV++KK+ + L GN+R+EGYC+DL E++
Sbjct: 406 VPFSDQQ--ISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463
Query: 472 TILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK 531
+ Y++ +V DGKYGA+D WNGMV EL+ +AD+AVAPL IT VRE+VIDFSK
Sbjct: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523
Query: 532 PFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY- 590
PFM+LGISI+ +KP + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+
Sbjct: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583
Query: 591 ---NPHPCNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 646
N P +P S N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLI
Sbjct: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643
Query: 647 IISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW 706
IISSYTANLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T FF++SKI+ Y+KMW
Sbjct: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703
Query: 707 AFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKG 763
++M S SV K+ +G+ RV S +AFL+EST E++ QR C+ ++GG +DSKG
Sbjct: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763
Query: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQN 819
YGV TP GS + +A+L+L E+G L +K KWW G C ++S + SAL + N
Sbjct: 764 YGVATPKGSALGTPVNLAVLKLSEQGILDKLKNKWWYDKGECGAKDSGSKDKTSALSLSN 823
Query: 820 IGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
+ G+F +L GL L++ VA+ EF YKS+ ++ K
Sbjct: 824 VAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK 858
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 611 bits (1575), Expect = e-174
Identities = 358/875 (40%), Positives = 516/875 (58%), Gaps = 51/875 (5%)
Query: 8 LSNPVFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINR 66
+ V R L+L LL G+S G + + GG+F E AFRFAV N
Sbjct: 7 MGQSVLRAVFFLVLGLL--GHSHGGFPNTISIGGLF----MRNTVQEHSAFRFAVQLYNT 60
Query: 67 NRTLLPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSI 121
N+ NTT L Y ++ +SF + C Q S GV AIFG S N + S
Sbjct: 61 NQ----NTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSF 116
Query: 122 CNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTG 181
C AL + + +D F + + P +L AIL L+ +KW+ +YD G
Sbjct: 117 CGALHTSFVTPSFP---TDADVQFVIQMRP---ALKGAILSLLGHYKWEKFVYLYDTERG 170
Query: 182 LIRLQELIKAPSRYNLRLKIRQLP--ADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGIL 239
LQ +++A + N ++ R + D ++ + +++EM R +E + DC E IL
Sbjct: 171 FSILQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTIL 230
Query: 240 KQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSME 299
+Q + +G + YHY+ L + +E + G N+TGF+I+N EN V I++W
Sbjct: 231 EQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWV-- 288
Query: 300 RLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTV------SSLQC--NRHK 351
RL P++ + + +AL +DA+ V++ A + + V S+ C N
Sbjct: 289 RLDEREFPEAK--NAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAV 346
Query: 352 PWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL 411
PW G +K +G+TG I F+ T G RT++ +DV +K G K G W+
Sbjct: 347 PWSQGIDIERALKMVQVQGMTGNIQFD-TYGRRTNYTIDVYEMKVSGSRKAGYWNEYERF 405
Query: 412 NMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELS 471
Q+ +N + S NR+++VTTILE PYV++KK+ + L GN+R+EGYC+DL E++
Sbjct: 406 VPFSDQQ--ISNDSASSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIA 463
Query: 472 TILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSK 531
+ Y++ +V DGKYGA+D WNGMV EL+ +AD+AVAPL IT VRE+VIDFSK
Sbjct: 464 KHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSK 523
Query: 532 PFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY- 590
PFM+LGISI+ +KP + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+
Sbjct: 524 PFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHL 583
Query: 591 ---NPHPCNPDSDV-VENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLI 646
N P +P S N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLI
Sbjct: 584 EDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLI 643
Query: 647 IISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMW 706
IISSYTANLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T FF++SKI+ Y+KMW
Sbjct: 644 IISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMW 703
Query: 707 AFMSSRRQSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKG 763
++M S SV K+ +G+ RV S +AFL+EST E++ QR C+ ++GG +DSKG
Sbjct: 704 SYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKG 763
Query: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EESKEASALGVQN 819
YGV TP GS + + +A+L+L E+G L +K KWW G C + + SAL + N
Sbjct: 764 YGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSN 823
Query: 820 IGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
+ G+F +L GL L++ VA+ EF YKS+ ++ K
Sbjct: 824 VAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMK 858
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 609 bits (1571), Expect = e-174
Identities = 334/805 (41%), Positives = 487/805 (60%), Gaps = 41/805 (5%)
Query: 76 LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWK 135
LT + + +SF + C Q S GV AIFG S N + S C L V I +
Sbjct: 11 LTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFP 70
Query: 136 HQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRY 195
+D F + + PD L A+L L+++++W +YD GL LQ ++ + +
Sbjct: 71 ---TDGTHPFVIQMRPD---LKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEK 124
Query: 196 NLR---LKIRQLPADTKDA--KPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTE 250
+ + + + D KD + L ++++ KE VI DC + I+ Q + +G +
Sbjct: 125 KWQVTAINVGNINNDKKDEMYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVK 184
Query: 251 YYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWS-MERLQAPPKPDS 309
YHYI L D+ ++ G N++GF+I++ +++ VS IE+WS +E + P
Sbjct: 185 GYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYP----- 239
Query: 310 GLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFGTRFMS 361
G + +AL YDAV V++ A + + + + N PW G
Sbjct: 240 GAHTTTIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIER 299
Query: 362 LIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGL--NMTESQKG 419
+K+ EGL+G I F++ NG R ++ ++++ LK G KIG W + +TE G
Sbjct: 300 ALKQVQVEGLSGNIKFDQ-NGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSG 358
Query: 420 KPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYE 479
N T L N++++VTTILE PYV+ KK+ + L GN+R+EGYC+DL E++ GF Y+
Sbjct: 359 ---NDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYK 415
Query: 480 IRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGIS 539
+ +V DGKYGA+D WNGMV EL+ KAD+A+APL IT VRE+VIDFSKPFM+LGIS
Sbjct: 416 LTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGIS 475
Query: 540 ILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPH---PCN 596
I+ +KP + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+
Sbjct: 476 IMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRE 535
Query: 597 PDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLA 656
S N F + NS WF +GA M+QG ++ P++LS RIVGG+WWFFTLIIISSYTANLA
Sbjct: 536 TQSSESTNEFGIFNSLWFSLGAFMRQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLA 595
Query: 657 AFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSV 716
AFLTVERM SPI+SA+DL+KQT+I YG ++ G+T FF++SKI+ +DKMW +M S SV
Sbjct: 596 AFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSV 655
Query: 717 LVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPMGSP 773
V++ EG+ RV S YA+L+EST E++ QR C+ ++GG +DSKGYG+ TP GS
Sbjct: 656 FVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSS 715
Query: 774 YRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQNIGGIFIVLAA 829
R + +A+L+L E+G L +K KWW G C ++S ++ SAL + N+ G+F +L
Sbjct: 716 LRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILVG 775
Query: 830 GLVLSVFVAVGEFLYKSKKNAQLEK 854
GL L++ VA+ EF YKS+ A+ K
Sbjct: 776 GLGLAMLVALIEFCYKSRAEAKRMK 800
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 593 bits (1529), Expect = e-169
Identities = 345/883 (39%), Positives = 507/883 (57%), Gaps = 47/883 (5%)
Query: 12 VFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL 70
+ R + LL W G + G ++ GG+F E AFR A+ N +
Sbjct: 3 IISRQIVLLFSGFW-GLAMGAFPSSVQIGGLF----IRNTDQEYTAFRLAIFLHNTS--- 54
Query: 71 LPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNAL 125
PN + L I +SF + C Q S GV AIFG S + + S C+AL
Sbjct: 55 -PNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL 113
Query: 126 GVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRL 185
HI ++ + F + L P SL A+L L+ ++W +YD G L
Sbjct: 114 ---HISLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSIL 167
Query: 186 QELIKAPSRYNLRLK-IRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALA 244
Q +++ + + I + + LL+E+ R +E + DC E IL+Q ++
Sbjct: 168 QAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVS 227
Query: 245 MGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304
+G + YHYI L + +E + + G N+TGF++++ V ++++W ++L
Sbjct: 228 VGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRW--KKLDQR 285
Query: 305 PKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFG 356
P S + + AL YD V V++ + + + + N PW G
Sbjct: 286 EYPGSETPPKYTS---ALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQG 342
Query: 357 TRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTES 416
+K+ +GLTG + F+ G R ++ +DV LK G K+G W+ L + +
Sbjct: 343 IDMERTLKQVRIQGLTGNVQFDHY-GRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQD 401
Query: 417 QKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGF 476
N T ++ NR+++VTTI+E PYV++KK+ + GND++EGYC+DL E++ +G
Sbjct: 402 VPTL-GNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGI 460
Query: 477 TYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTL 536
Y+I +V DGKYGA+D WNGMV EL+ KA++A+APL IT VRE+VIDFSKPFM+L
Sbjct: 461 KYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSL 520
Query: 537 GISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHP-- 594
GISI+ +KP + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+ P
Sbjct: 521 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPED 580
Query: 595 -CNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 653
SD N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTA
Sbjct: 581 GKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 640
Query: 654 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRR 713
NLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T FF++SKI+ Y+KMW +M S
Sbjct: 641 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAE 700
Query: 714 QSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPM 770
SV ++ EG+ RV S +AFL+EST E++ QR C+ ++GG +DSKGYGV TP
Sbjct: 701 PSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPK 760
Query: 771 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEES---KEASALGVQNIGGIFIV 826
GS + +A+L+L E G L +K KWW G C ++S + SAL + N+ G+F +
Sbjct: 761 GSSLGTPVNLAVLKLSEAGVLDKLKNKWWYDKGECGPKDSGSKDKTSALSLSNVAGVFYI 820
Query: 827 LAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSL 869
L GL L++ VA+ EF YKS+ A+ K +F A+ + R+S+
Sbjct: 821 LVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEAIRNKARLSI 863
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 586 bits (1511), Expect = e-167
Identities = 340/868 (39%), Positives = 498/868 (57%), Gaps = 47/868 (5%)
Query: 12 VFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL 70
+ R + LL W G + G ++ GG+F E AFR A+ N +
Sbjct: 3 IISRQIVLLFSGFW-GLAMGAFPSSVQIGGLF----IRNTDQEYTAFRLAIFLHNTS--- 54
Query: 71 LPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNAL 125
PN + L I +SF + C Q S GV AIFG S + + S C+AL
Sbjct: 55 -PNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL 113
Query: 126 GVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRL 185
HI ++ + F + L P SL A+L L+ ++W +YD G L
Sbjct: 114 ---HISLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSIL 167
Query: 186 QELIKAPSRYNLRLK-IRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALA 244
Q +++ + + I + + LL+E+ R +E + DC E IL+Q ++
Sbjct: 168 QAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVS 227
Query: 245 MGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304
+G + YHYI L + +E + + G N+TGF++++ V ++++W ++L
Sbjct: 228 VGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRW--KKLDQR 285
Query: 305 PKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQ--------CNRHKPWRFG 356
P S + + AL YD V V++ + + + + N PW G
Sbjct: 286 EYPGSETPPKYTS---ALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQG 342
Query: 357 TRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTES 416
+K+ +GLTG + F+ G R ++ +DV LK G K+G W+ L + +
Sbjct: 343 IDMERTLKQVRIQGLTGNVQFDHY-GRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQD 401
Query: 417 QKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGF 476
N T ++ NR+++VTTI+E PYV++KK+ + GND++EGYC+DL E++ +G
Sbjct: 402 VPTL-GNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGI 460
Query: 477 TYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTL 536
Y+I +V DGKYGA+D WNGMV EL+ KA++A+APL IT VRE+VIDFSKPFM+L
Sbjct: 461 KYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSL 520
Query: 537 GISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHP-- 594
GISI+ +KP + PGVFSFL+PL+ +IWM I+ AY+GVS VLF+++RFSPYEW+ P
Sbjct: 521 GISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPED 580
Query: 595 -CNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTA 653
SD N F + NS WF +GA MQQG ++ P++LS RIVGG+WWFFTLIIISSYTA
Sbjct: 581 GKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTA 640
Query: 654 NLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRR 713
NLAAFLTVERM SPI+SA+DLAKQT+I YG ++ G+T FF++SKI+ Y+KMW +M S
Sbjct: 641 NLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAE 700
Query: 714 QSVLVKSNEEGIQRVLTS--DYAFLMESTTIEFVTQRN-CNLTQIGGLIDSKGYGVGTPM 770
SV ++ EG+ RV S +AFL+EST E++ QR C+ ++GG +DSKGYGV TP
Sbjct: 701 PSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPK 760
Query: 771 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPE---EESKEASALGVQNIGGIFIV 826
GS + + +A+L+L E+G L +K KWW G C + + SAL + N+ G+F +
Sbjct: 761 GSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYI 820
Query: 827 LAAGLVLSVFVAVGEFLYKSKKNAQLEK 854
L GL L++ VA+ EF YKS+ A+ K
Sbjct: 821 LVGGLGLAMLVALIEFCYKSRAEAKRMK 848
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 362 bits (928), Expect = 1e-99
Identities = 264/907 (29%), Positives = 447/907 (49%), Gaps = 85/907 (9%)
Query: 35 VLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKK 94
++ G IFE + ++ F+ AV+ ++ N +L + +TY + I + F+A ++
Sbjct: 23 IIHIGAIFEENAA----KDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQE 78
Query: 95 ACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFS 154
ACD ++ G+ A+ + +SANA+QS+ +A+ +PH+ + ++ + + +++ PD
Sbjct: 79 ACDLMTQGILALVTSTGCASANALQSLTDAMHIPHLFVQ-RNPGGSPRTACHLNPSPDGE 137
Query: 155 S----------LSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQL 204
+ L+ +L LV +W+ + YD + LQ + SR L + ++++
Sbjct: 138 AYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLGLDVSLQKV 197
Query: 205 PADTKDAKPLLKEMKRGKEFH--------VIFDCSHEMAAGILKQALAMGMMTEYYHYIF 256
+ L + +E + I S + A + +A+ + ++ H++F
Sbjct: 198 DKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASKDSHWVF 257
Query: 257 TTLDLFALDVEPYRYSGVN-MTGFRIL----------NTENTQVSSIIEKWSMERLQAPP 305
++ ++ +S + MT R + N ++SS++
Sbjct: 258 VNEEISDPEILDLVHSALGRMTVVRQIFPSAKDNQKCTRNNHRISSLL-----------C 306
Query: 306 KPDSGLLDGFMTTDAALMYDAVHVVSVA----VQQFPQMTVSSLQCNRH--KPWRFGTRF 359
P G L ++ L YD+V +++ A ++ +++SL C R KPW G
Sbjct: 307 DPQEGYLQMLQISNLYL-YDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSM 365
Query: 360 MSLIKEAHWEGLTGRITFNK-TNGLRTDFDLDVISLKE---EGLEKIGTWDPASGLNMTE 415
+ IK+ H GLTG + F + ++ F++ + E + + K+ TWD GLN +
Sbjct: 366 LDTIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGLNGSL 425
Query: 416 SQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILG 475
++ + L +L V T+LEEP+V+ ++ L R++G+ ID+L L+ LG
Sbjct: 426 QERPMGSR----LQGLTLKVVTVLEEPFVMV--AENILGQPKRYKGFSIDVLDALAKALG 479
Query: 476 FTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMT 535
F YEI DG+YG Q N WNGM+ ELI +ADLA++ + IT RE V+DFSK +M
Sbjct: 480 FKYEIYQAPDGRYGHQLH-NTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMD 538
Query: 536 LGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPC 595
+ IL +KP +FS P +W I A V ++FV+ R +
Sbjct: 539 YSVGILIKKPE-EKISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRAQSAAQP 597
Query: 596 NPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANL 655
P + TL ++ W GA +QQG E +++ RIV G WW FTLI+ SSYTANL
Sbjct: 598 RPSASA-----TLHSAIWIVYGAFVQQGGESSVNSMAMRIVMGSWWLFTLIVCSSYTANL 652
Query: 656 AAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKK------SKISTYDKMWAFM 709
AAFLTV RM++PI + DL+KQ ++ YG V D A +F+ + ST+ ++W +
Sbjct: 653 AAFLTVSRMDNPIRTFQDLSKQVEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTI 712
Query: 710 SSR-RQSVLVKSNEEGIQRVLTSDYAFLMESTTIEF--VTQRNCNLTQIGGLIDSKGYGV 766
S V S EGI++ +YAFL + +E+ +T +C++T IG I SKGYG+
Sbjct: 713 SKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGI 772
Query: 767 GTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-CPEEESKEASA----LGVQNIG 821
GSPYRD + IL+LQ+ G L ++K+KWW G C A A L + +
Sbjct: 773 ALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGRCDLTSHASAQADGKSLKLHSFA 832
Query: 822 GIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEEL--RMSLKCQRRLKHKP 879
G+F +LA GL+L+ VA E + S + Q + +E++ RM+ + HK
Sbjct: 833 GVFCILAIGLLLACLVAALELWWNSNRCHQETPKEDKEVNLEQVHRRMNSLMDEDIAHKQ 892
Query: 880 QAPVIVK 886
+P ++
Sbjct: 893 ISPASIE 899
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 357 bits (916), Expect = 3e-98
Identities = 258/877 (29%), Positives = 435/877 (49%), Gaps = 80/877 (9%)
Query: 29 SQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDS 88
S ++ G IF+ ES E FR AV +N+N +L +T+ ++ +
Sbjct: 20 SANADSIIHIGAIFD--ESAKKDDE--VFRTAVGDLNQNEEILQTEKITFSVTFVDGNNP 75
Query: 89 FEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHI----------QTRWKHQV 138
F+A ++AC+ ++ G+ A+ +SA ++QS+ +A+ +PH+ ++
Sbjct: 76 FQAVQEACELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTR 135
Query: 139 SDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLR 198
S+ D + +S+ P L IL +V + W+ + YD + +QE + S+ +
Sbjct: 136 SNRNDDYTLSVRPPVY-LHDVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMD 194
Query: 199 LKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYY------ 252
+ ++++ + L + R +E + D A ++ A A +TE
Sbjct: 195 VALQKVENNINKMITTLFDTMRIEELNRYRDTLRR-AILVMNPATAKSFITEVVETNLVA 253
Query: 253 ---HYIFTTLDLFALDV-EPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPD 308
H+I ++ +DV E R S +T R Q + + S + +
Sbjct: 254 FDCHWIIINEEINDVDVQELVRRSIGRLTIIR-------QTFPVPQNISQRCFRGNHRIS 306
Query: 309 SGLLDGF------MTTDAALMYDAVHVVSVA----VQQFPQMTVSSLQCNRH--KPWRFG 356
S L D M +YD V +++ A ++ +++SL C R KPW+ G
Sbjct: 307 STLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGG 366
Query: 357 TRFMSLIKEAHWEGLTGRITFNKTNGL-RTDFDLDVISLKEE---GLEKIGTWDPASGLN 412
+ IK+ GLTG + F + G F++ + EE G+ K+G W+P +GLN
Sbjct: 367 RSMLETIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLN 426
Query: 413 MTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELST 472
+ + K + +++ L V T+LEEP+V+ S+ L +++G+ ID+L LS
Sbjct: 427 GSLTDK----KLENNMRGVVLRVVTVLEEPFVMV--SENVLGKPKKYQGFSIDVLDALSN 480
Query: 473 ILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
LGF YEI + D KYG+ + +G WNG+V EL+ +AD+ ++ L IT RE V+DF+
Sbjct: 481 YLGFNYEIYVAPDHKYGSPQE-DGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTR 539
Query: 533 FMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNP 592
+M + +L R+ T +F+ L P +W I L V +++++ W NP
Sbjct: 540 YMDYSVGVLLRRAEKT-VDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------NWLNP 592
Query: 593 HPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYT 652
S + TL NS WF G+ +QQG E+ L+TR++ G WW F LI+ISSYT
Sbjct: 593 PRLQMGS---MTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYT 649
Query: 653 ANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKI------STYDKMW 706
ANLAAFLT+ R+ES I S DL+KQT+I YG V D A + + S Y +MW
Sbjct: 650 ANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMW 709
Query: 707 AFMS-SRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFV--TQRNCNLTQIGGLIDSKG 763
++ S V ++ GIQ+V +YAF+ ++ +E+V +C+ IG + +G
Sbjct: 710 RMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRG 769
Query: 764 YGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNG-----CPEEESKEASALGVQ 818
YG+ GSPYRD + IL+LQ+ G + ++K KWW NG + ++ AL ++
Sbjct: 770 YGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIK 829
Query: 819 NIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKR 855
+ G+F +LAAG+VLS F+A+ E + +K +++ +
Sbjct: 830 SFAGVFCILAAGIVLSCFIAMLETWWNKRKGSRVPSK 866
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 258 bits (660), Expect = 1e-68
Identities = 231/895 (25%), Positives = 410/895 (45%), Gaps = 130/895 (14%)
Query: 54 ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107
E FR AVN N+ + L T++T+ I + A D +S V AI
Sbjct: 39 EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93
Query: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162
P+ + V +P + + + +K ++ P +S S +
Sbjct: 94 HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153
Query: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218
+++ + W + +V DD G RL+ L++ R + K+ Q TK+ LL E
Sbjct: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211
Query: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278
K + +I S + AA + + A + M Y ++ ++ RY+ + G
Sbjct: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268
Query: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338
+++N +N ++A + DAV VV+ AV +
Sbjct: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296
Query: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393
+ +T C W+ G F ++ + + +G+TGR+ FN+ +G R + +++
Sbjct: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355
Query: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447
L+ L ++G ++ G ++ + + G+ + L + TI +EP+V K
Sbjct: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412
Query: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476
K + + G ND G +CIDLL +L+ + F
Sbjct: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472
Query: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
TYE+ LV DGK+G Q+ N +WNGM+ EL+ +AD+ VAPL I R + I+FSKP
Sbjct: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532
Query: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590
F G++IL +K P T + SF+ P +W+ + L+ V+ +L+++ RFSP+ +
Sbjct: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589
Query: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649
+ + D + TL ++ WF G L+ G E P++ S RI+G +W F +II++
Sbjct: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645
Query: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705
SYTANLAAFL ++R E I +D + K Y V+ + +F++ ++ST M
Sbjct: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702
Query: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764
+ M +S E IQ V + +AF+ +S +EF + C+L G L G+
Sbjct: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758
Query: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824
G+G SP++ ++++IL+ E G + + + W R C + S + L +N+ G+F
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817
Query: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKP 879
+++A G+V +F+ E YK K+A+ ++ A V R +L+ ++ + +P
Sbjct: 818 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQDRKSGRAEP 872
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 257 bits (657), Expect = 3e-68
Identities = 230/886 (25%), Positives = 405/886 (45%), Gaps = 130/886 (14%)
Query: 54 ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107
E FR AVN N+ + L T++T+ I + A D +S V AI
Sbjct: 39 EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93
Query: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162
P+ + V +P + + + +K ++ P +S S +
Sbjct: 94 HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153
Query: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218
+++ + W + +V DD G RL+ L++ R + K+ Q TK+ LL E
Sbjct: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211
Query: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278
K + +I S + AA + + A + M Y ++ ++ RY+ + G
Sbjct: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268
Query: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338
+++N +N ++A + DAV VV+ AV +
Sbjct: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296
Query: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393
+ +T C W+ G F ++ + + +G+TGR+ FN+ +G R + +++
Sbjct: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355
Query: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447
L+ L ++G ++ G ++ + + G+ + L + TI +EP+V K
Sbjct: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412
Query: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476
K + + G ND G +CIDLL +L+ + F
Sbjct: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472
Query: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
TYE+ LV DGK+G Q+ N +WNGM+ EL+ +AD+ VAPL I R + I+FSKP
Sbjct: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532
Query: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590
F G++IL +K P T + SF+ P +W+ + L+ V+ +L+++ RFSP+ +
Sbjct: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589
Query: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649
+ + D + TL ++ WF G L+ G E P++ S RI+G +W F +II++
Sbjct: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645
Query: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705
SYTANLAAFL ++R E I +D + K Y V+ + +F++ ++ST M
Sbjct: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702
Query: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764
+ M +S E IQ V + +AF+ +S +EF + C+L G L G+
Sbjct: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758
Query: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824
G+G SP++ ++++IL+ E G + + + W R C + S + L +N+ G+F
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817
Query: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLK 870
+++A G+V +F+ E YK K+A+ ++ A V R +L+
Sbjct: 818 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQ 863
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 257 bits (657), Expect = 3e-68
Identities = 230/886 (25%), Positives = 405/886 (45%), Gaps = 130/886 (14%)
Query: 54 ELAFRFAVNTINRN----RTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIF-- 107
E FR AVN N+ + L T++T+ I + A D +S V AI
Sbjct: 39 EQMFREAVNQANKRHGSWKIQLNATSVTHKPNAIQM-----ALSVCEDLISSQVYAILVS 93
Query: 108 ---GPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSF--YVSLYPDFSSLSRAILD 162
P+ + V +P + + + +K ++ P +S S +
Sbjct: 94 HPPTPNDHFTPTPVSYTAGFYRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFE 153
Query: 163 LVQFFKWK-TVTVVYDDSTGLI---RLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEM 218
+++ + W + +V DD G RL+ L++ R + K+ Q TK+ LL E
Sbjct: 154 MMRVYSWNHIILLVSDDHEGRAAQKRLETLLE--ERESKAEKVLQFDPGTKNVTALLMEA 211
Query: 219 KRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTG 278
K + +I S + AA + + A + M Y ++ ++ RY+ + G
Sbjct: 212 KELEARVIILSASEDDAATVYRAAAMLNMTGSGYVWLVGEREISG---NALRYAPDGILG 268
Query: 279 FRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFP 338
+++N +N ++A + DAV VV+ AV +
Sbjct: 269 LQLINGKN--------------------------------ESAHISDAVGVVAQAVHELL 296
Query: 339 Q---MTVSSLQC-NRHKPWRFGTRFMSLIKEAHW-EGLTGRITFNKTNGLRTDFDLDVIS 393
+ +T C W+ G F ++ + + +G+TGR+ FN+ +G R + +++
Sbjct: 297 EKENITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNE-DGDRKFANYSIMN 355
Query: 394 LKEEGLEKIGTWDPASGLNMTESQK------GKPANITDSLSNRSLIVTTILEEPYVLFK 447
L+ L ++G ++ G ++ + + G+ + L + TI +EP+V K
Sbjct: 356 LQNRKLVQVGIYN---GTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQEPFVYVK 412
Query: 448 --------KSDKPLYG-----------NDRFEG------------YCIDLLRELSTILGF 476
K + + G ND G +CIDLL +L+ + F
Sbjct: 413 PTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIKLARTMNF 472
Query: 477 TYEIRLVEDGKYGAQDDANG----QWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKP 532
TYE+ LV DGK+G Q+ N +WNGM+ EL+ +AD+ VAPL I R + I+FSKP
Sbjct: 473 TYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQYIEFSKP 532
Query: 533 FMTLGISILYRK--PNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWY 590
F G++IL +K P T + SF+ P +W+ + L+ V+ +L+++ RFSP+ +
Sbjct: 533 FKYQGLTILVKKEIPRST---LDSFMQPFQSTLWLLVGLSVHVVAVMLYLLDRFSPFGRF 589
Query: 591 NPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIIS 649
+ + D + TL ++ WF G L+ G E P++ S RI+G +W F +II++
Sbjct: 590 KVNSEEEEEDAL----TLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVA 645
Query: 650 SYTANLAAFLTVERMESPIDSADDLAKQT---KIEYGAVEDGATMTFFKKS-KISTYDKM 705
SYTANLAAFL ++R E I +D + K Y V+ + +F++ ++ST M
Sbjct: 646 SYTANLAAFLVLDRPEERITGINDPRLRNPSDKFIYATVKQSSVDIYFRRQVELST---M 702
Query: 706 WAFMSSRRQSVLVKSNEEGIQRVLTSD-YAFLMESTTIEFVTQRNCNLTQIGGLIDSKGY 764
+ M +S E IQ V + +AF+ +S +EF + C+L G L G+
Sbjct: 703 YRHMEKHN----YESAAEAIQAVRDNKLHAFIWDSAVLEFEASQKCDLVTTGELFFRSGF 758
Query: 765 GVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIF 824
G+G SP++ ++++IL+ E G + + + W R C + S + L +N+ G+F
Sbjct: 759 GIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQEC-DSRSNAPATLTFENMAGVF 817
Query: 825 IVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLK 870
+++A G+V +F+ E YK K+A+ ++ A V R +L+
Sbjct: 818 MLVAGGIVAGIFLIFIEIAYKRHKDARRKQMQLAFAAVNVWRKNLQ 863
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor
[Homo sapiens]
Length = 1484
Score = 192 bits (488), Expect = 1e-48
Identities = 142/494 (28%), Positives = 241/494 (48%), Gaps = 64/494 (12%)
Query: 395 KEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLF-------- 446
KE E++G W S L M + T+ + L + T+ E P+V+
Sbjct: 369 KERKWERVGKWKDKS-LQMKYYVWPRMCPETEEQEDDHLSIVTLEEAPFVIVESVDPLSG 427
Query: 447 -----------------KKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYG 489
K ++P Y +G+CID+L+++S + FTY++ LV +GK+G
Sbjct: 428 TCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTNGKHG 487
Query: 490 AQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT- 548
+ NG WNGM+ E++ +A +AV L I R +V+DFS PF+ GIS++ + NGT
Sbjct: 488 KK--INGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTV 545
Query: 549 NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNPHPCNPDS-DVVENNF 606
+P +FL P S D+W+ + + L VS V +FV FSP + + C D + +F
Sbjct: 546 SPS--AFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGY---NRCLADGREPGGPSF 600
Query: 607 TLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERME 665
T+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E
Sbjct: 601 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYV 660
Query: 666 SPIDSADDLAKQ------TKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVK 719
+ D Q +G V +G+T +++ + Y +M A+M K
Sbjct: 661 DQVSGLSDKKFQRPNDFSPPFRFGTVPNGST----ERNIRNNYAEMHAYMG--------K 708
Query: 720 SNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNLTQIGG--LIDSKGYGVGTPM 770
N+ G+ L S AF+ ++ + ++ R+ C L IG + S GYG+
Sbjct: 709 FNQRGVDDALLSLKTGKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQK 768
Query: 771 GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAG 830
S ++ ++ +AILQL +G++ ++ W G E+ +S L + N+ G+F +L A
Sbjct: 769 DSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAA 828
Query: 831 LVLSVFVAVGEFLY 844
+ LS+ + E L+
Sbjct: 829 MALSLITFICEHLF 842
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 188 bits (477), Expect = 2e-47
Identities = 182/694 (26%), Positives = 318/694 (45%), Gaps = 111/694 (15%)
Query: 204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263
L +DAK + ++K+ ++ CS + A IL +A ++G+ + +I +L
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGN 264
Query: 264 LDVEPYRY-SGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAAL 322
++ P + SG+ +S + W L+A + G+L TT A+
Sbjct: 265 TELIPKEFPSGL--------------ISVSYDDWDYS-LEARVRDGIGIL----TTAASS 305
Query: 323 MYDAVHVVSVAVQQ-FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTN 381
M + + A + QM + + P+ W+G T
Sbjct: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVT---------WDGKDLSFT---EE 353
Query: 382 GLRTDFDLDVISL-KEEGLEKIGTWDPASGLNMTESQKGKPANITD-SLSNRSLIVTTIL 439
G + L VI L K+ EK+G W+ + L++ + + + +D + L + T+
Sbjct: 354 GYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412
Query: 440 EEPYVLFKKSDKPL----------------YGNDRFEG---------YCIDLLRELSTIL 474
E P+V+ + D PL N EG +CID+L++LS +
Sbjct: 413 EAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471
Query: 475 GFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFM 534
FTY++ LV +GK+G + N WNGM+ E++ +A +AV L I R +V+DFS PF+
Sbjct: 472 KFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFV 529
Query: 535 TLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNP 592
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV FSP YN
Sbjct: 530 ETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNR 586
Query: 593 H------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTL 645
+ P P +FT+ + W G + + PK +++I+ +W FF +
Sbjct: 587 NLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639
Query: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVEDGATMTFFKKSKI 699
I ++SYTANLAAF+ E + D Q +Y G V +G+T +++
Sbjct: 640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIR 695
Query: 700 STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNL 752
+ Y M +M+ K N++G++ L S AF+ ++ + + R+ C L
Sbjct: 696 NNYPYMHQYMT--------KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747
Query: 753 TQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESK 810
IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G E+
Sbjct: 748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEV 807
Query: 811 EASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
+S L + N+ G+F +LAA + LS+ + E L+
Sbjct: 808 MSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 188 bits (477), Expect = 2e-47
Identities = 182/694 (26%), Positives = 318/694 (45%), Gaps = 111/694 (15%)
Query: 204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263
L +DAK + ++K+ ++ CS + A IL +A ++G+ + +I +L
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGN 264
Query: 264 LDVEPYRY-SGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAAL 322
++ P + SG+ +S + W L+A + G+L TT A+
Sbjct: 265 TELIPKEFPSGL--------------ISVSYDDWDYS-LEARVRDGIGIL----TTAASS 305
Query: 323 MYDAVHVVSVAVQQ-FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTN 381
M + + A + QM + + P+ W+G T
Sbjct: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVT---------WDGKDLSFT---EE 353
Query: 382 GLRTDFDLDVISL-KEEGLEKIGTWDPASGLNMTESQKGKPANITD-SLSNRSLIVTTIL 439
G + L VI L K+ EK+G W+ + L++ + + + +D + L + T+
Sbjct: 354 GYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412
Query: 440 EEPYVLFKKSDKPL----------------YGNDRFEG---------YCIDLLRELSTIL 474
E P+V+ + D PL N EG +CID+L++LS +
Sbjct: 413 EAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471
Query: 475 GFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFM 534
FTY++ LV +GK+G + N WNGM+ E++ +A +AV L I R +V+DFS PF+
Sbjct: 472 KFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFV 529
Query: 535 TLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNP 592
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV FSP YN
Sbjct: 530 ETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNR 586
Query: 593 H------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTL 645
+ P P +FT+ + W G + + PK +++I+ +W FF +
Sbjct: 587 NLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639
Query: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVEDGATMTFFKKSKI 699
I ++SYTANLAAF+ E + D Q +Y G V +G+T +++
Sbjct: 640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIR 695
Query: 700 STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNL 752
+ Y M +M+ K N++G++ L S AF+ ++ + + R+ C L
Sbjct: 696 NNYPYMHQYMT--------KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747
Query: 753 TQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESK 810
IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G E+
Sbjct: 748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEV 807
Query: 811 EASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
+S L + N+ G+F +LAA + LS+ + E L+
Sbjct: 808 MSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 188 bits (477), Expect = 2e-47
Identities = 182/694 (26%), Positives = 318/694 (45%), Gaps = 111/694 (15%)
Query: 204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263
L +DAK + ++K+ ++ CS + A IL +A ++G+ + +I +L
Sbjct: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGN 264
Query: 264 LDVEPYRY-SGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAAL 322
++ P + SG+ +S + W L+A + G+L TT A+
Sbjct: 265 TELIPKEFPSGL--------------ISVSYDDWDYS-LEARVRDGIGIL----TTAASS 305
Query: 323 MYDAVHVVSVAVQQ-FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTN 381
M + + A + QM + + P+ W+G T
Sbjct: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVT---------WDGKDLSFT---EE 353
Query: 382 GLRTDFDLDVISL-KEEGLEKIGTWDPASGLNMTESQKGKPANITD-SLSNRSLIVTTIL 439
G + L VI L K+ EK+G W+ + L++ + + + +D + L + T+
Sbjct: 354 GYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412
Query: 440 EEPYVLFKKSDKPL----------------YGNDRFEG---------YCIDLLRELSTIL 474
E P+V+ + D PL N EG +CID+L++LS +
Sbjct: 413 EAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471
Query: 475 GFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFM 534
FTY++ LV +GK+G + N WNGM+ E++ +A +AV L I R +V+DFS PF+
Sbjct: 472 KFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFV 529
Query: 535 TLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNP 592
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV FSP YN
Sbjct: 530 ETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNR 586
Query: 593 H------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTL 645
+ P P +FT+ + W G + + PK +++I+ +W FF +
Sbjct: 587 NLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639
Query: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVEDGATMTFFKKSKI 699
I ++SYTANLAAF+ E + D Q +Y G V +G+T +++
Sbjct: 640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIR 695
Query: 700 STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNL 752
+ Y M +M+ K N++G++ L S AF+ ++ + + R+ C L
Sbjct: 696 NNYPYMHQYMT--------KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747
Query: 753 TQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESK 810
IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G E+
Sbjct: 748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEV 807
Query: 811 EASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
+S L + N+ G+F +LAA + LS+ + E L+
Sbjct: 808 MSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 174 bits (442), Expect = 3e-43
Identities = 135/473 (28%), Positives = 230/473 (48%), Gaps = 54/473 (11%)
Query: 389 LDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK 448
L V +L+E + DP SG I DS+ RS + T P
Sbjct: 432 LTVATLEERPFVIVEPADPISG-----------TCIRDSVPCRSQLNRTHSPPP------ 474
Query: 449 SDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDH 508
D P +G+CID+L+ L+ +GF+Y++ LV +GK+G + D G WNGM+ E+
Sbjct: 475 -DAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKID--GVWNGMIGEVFYQ 531
Query: 509 KADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYI 567
+AD+A+ L I R +++DFS PF+ GIS++ + NGT +P +FL P SP +W+ +
Sbjct: 532 RADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPS--AFLEPYSPAVWVMM 589
Query: 568 LLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM 627
+ L V V I + YN + FT+ S W + AL+ S +
Sbjct: 590 FVMCLTVVAVTVFIFEYLSPVGYN-RSLATGKRPGGSTFTIGKSIWL-LWALVFNNSVPV 647
Query: 628 --PKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQ------TK 679
P+ +++I+ +W FF +I ++SYTANLAAF+ E + D Q
Sbjct: 648 ENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPP 707
Query: 680 IEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----A 734
+++G V +G+T +K+ S Y M ++M V+ N+ ++ LT A
Sbjct: 708 LKFGTVPNGST----EKNIRSNYPDMHSYM--------VRYNQPRVEEALTQLKAGKLDA 755
Query: 735 FLMESTTIEFVTQRN--CNLTQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGK 790
F+ ++ + ++ +++ C L IG + + GYG+ GS ++ I +A+LQ + +
Sbjct: 756 FIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDE 815
Query: 791 LHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFL 843
+ M++ W G ++ +S L + N+ G+F +L + LS+ V E L
Sbjct: 816 IEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHL 868
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 171 bits (432), Expect = 4e-42
Identities = 136/496 (27%), Positives = 238/496 (47%), Gaps = 72/496 (14%)
Query: 391 VISLKEEGL-EKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKS 449
VI+L L E +G W+ A++ + +R L V T+ E P+V+ +
Sbjct: 360 VIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESP 419
Query: 450 DKPLYG------------NDRF-------------EGYCIDLLRELSTILGFTYEIRLVE 484
D G N F +G+CID+L++L+ ++ F+Y++ LV
Sbjct: 420 DPGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479
Query: 485 DGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRK 544
+GK+G + G WNGM+ E+ +AD+A+ L I R +++DFS PF+ GIS++ +
Sbjct: 480 NGKHGKR--VRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVAR 537
Query: 545 PNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVE 603
NGT +P +FL P SP +W+ + V C+ V +E+++P N + +
Sbjct: 538 SNGTVSPS--AFLEPYSPAVWVMMF-----VMCLTVVAITVFMFEYFSPVSYNQNLTRGK 590
Query: 604 NN----FTLLNSFWFGVGALMQQGSELM--PKALSTRIVGGIWWFFTLIIISSYTANLAA 657
+ FT+ S W + AL+ S + P+ +++I+ +W FF +I ++SYTANLAA
Sbjct: 591 KSGGPAFTIGKSVWL-LWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAA 649
Query: 658 FLTVERMESPIDSADDLAKQTK------IEYGAVEDGATMTFFKKSKISTYDKMWAFMSS 711
F+ E+ + D Q +G V +G+T +++ S Y M M
Sbjct: 650 FMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGST----ERNIRSNYRDMHTHM-- 703
Query: 712 RRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNLTQIGG--LIDSK 762
VK N+ ++ LTS AF+ ++ + ++ ++ C L IG + +
Sbjct: 704 ------VKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATT 757
Query: 763 GYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGG 822
GYG+ S ++ I +A+LQ +G+ ++ W G E+ +S L + N+ G
Sbjct: 758 GYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAG 817
Query: 823 IF--IVLAAGLVLSVF 836
+F +++A GL L VF
Sbjct: 818 VFYMLLVAMGLALLVF 833
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
[Homo sapiens]
Length = 1115
Score = 159 bits (401), Expect = 1e-38
Identities = 121/466 (25%), Positives = 215/466 (46%), Gaps = 43/466 (9%)
Query: 461 GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAIT 520
GYCIDLL +++ + F +++ +V DGKYGA NG W G+V +L+ A +AV +I
Sbjct: 578 GYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWK--NGHWTGLVGDLLRGTAHMAVTSFSIN 635
Query: 521 YVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFV 580
R +VIDF+ PF + + IL R + P + +F+ PL +W+ I +A L ++ V
Sbjct: 636 TARSQVIDFTSPFFSTSLGILVRTRDTAAP-IGAFMWPLHWTMWLGIFVA-LHITAVFLT 693
Query: 581 IARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGI 639
+ YEW +P P F+ ++ L + + PK + R + +
Sbjct: 694 L-----YEWKSPFGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNL 748
Query: 640 WWFFTLIIISSYTANLAAFLTVERMESPIDSADDLA---KQTKIEYGAVEDGATMTFFKK 696
W F + +S+YTANLAA + E++ + D +G V + + + ++
Sbjct: 749 WAIFCMFCLSTYTANLAAVMVGEKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQ 808
Query: 697 SKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY---AFLMESTTIEFVT--QRNCN 751
S + +M +M RR + V + +G++ + AF+M+ +++ +C
Sbjct: 809 S----FPEMHEYM--RRYN--VPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCK 860
Query: 752 LTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEE--S 809
L +G +GYG+G P SP I+ I Q + G + M+ +KW+R C +
Sbjct: 861 LLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAV 920
Query: 810 KEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY----------KSK-----KNAQLEK 854
E +G+++ G+F++L G LS+ +GE + KSK +Q
Sbjct: 921 TETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLH 980
Query: 855 RSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR 900
R+ ++ +EE + K +R K P + N+ N R+
Sbjct: 981 RAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRK 1026
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 157 bits (398), Expect = 3e-38
Identities = 121/432 (28%), Positives = 207/432 (47%), Gaps = 35/432 (8%)
Query: 461 GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAIT 520
GYCIDLL L+ F +E+ LV DGKYGA D G+W G+V +L+ +A +AV +I
Sbjct: 478 GYCIDLLERLAEDTPFDFELYLVGDGKYGALRD--GRWTGLVGDLLAGRAHMAVTSFSIN 535
Query: 521 YVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFV 580
R +V+DF+ PF + + I+ R + +P + +F+ PL W LGV L +
Sbjct: 536 SARSQVVDFTSPFFSTSLGIMVRARDTASP-IGAFMWPLHWSTW-------LGVFAALHL 587
Query: 581 IARF-SPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGG 638
A F + YEW +P+ P F+ ++ L ++ S PK + R++
Sbjct: 588 TALFLTVYEWRSPYGLTPRGRNRSTVFSYSSALNLCYAILFRRTVSSKTPKCPTGRLLMN 647
Query: 639 IWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIE---YGAVEDGATMTFFK 695
+W F L+++SSYTANLAA + ++ + D + +G V + + + K
Sbjct: 648 LWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPAQGFRFGTVWESSAEAYIK 707
Query: 696 KSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSD----YAFLMESTTIEFVT--QRN 749
KS + M A M RR S + G+ +LTSD AF+M+ + +++ +
Sbjct: 708 KS----FPDMHAHM--RRHS--APTTPRGV-AMLTSDPPKLNAFIMDKSLLDYEVSIDAD 758
Query: 750 CNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEE-- 807
C L +G +GYG+G P SP ++ I + + G + ++ +KW++ C +
Sbjct: 759 CKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVF 818
Query: 808 ESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRM 867
E + + + G+F++L GL ++ ++GE + ++ K S + L
Sbjct: 819 AVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFFRLALPRIRKG---SRLQYWLHT 875
Query: 868 SLKCQRRLKHKP 879
S K R L +P
Sbjct: 876 SQKIHRALNTEP 887
>gi|116284390 glutamate receptor, ionotrophic, AMPA 4 isoform 3
precursor [Homo sapiens]
Length = 433
Score = 135 bits (339), Expect = 2e-31
Identities = 115/443 (25%), Positives = 194/443 (43%), Gaps = 37/443 (8%)
Query: 12 VFRRTVKLLLCLLWIGYSQGT-THVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL 70
+ R + LL W G + G ++ GG+F E AFR A+ N +
Sbjct: 3 IISRQIVLLFSGFW-GLAMGAFPSSVQIGGLF----IRNTDQEYTAFRLAIFLHNTS--- 54
Query: 71 LPNTT-----LTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNAL 125
PN + L I +SF + C Q S GV AIFG S + + S C+AL
Sbjct: 55 -PNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSAL 113
Query: 126 GVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRL 185
HI ++ + F + L P SL A+L L+ ++W +YD G L
Sbjct: 114 ---HISLITPSFPTEGESQFVLQLRP---SLRGALLSLLDHYEWNCFVFLYDTDRGYSIL 167
Query: 186 QELIKAPSRYNLRLK-IRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALA 244
Q +++ + + I + + LL+E+ R +E + DC E IL+Q ++
Sbjct: 168 QAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVS 227
Query: 245 MGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAP 304
+G + YHYI L + +E + + G N+TGF++++ V ++++W ++L
Sbjct: 228 VGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVIKLMDRW--KKLDQR 285
Query: 305 PKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTV--------SSLQCNRHKPWRFG 356
P S + +AL YD V V++ + + + N PW G
Sbjct: 286 EYPGSETPPKY---TSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQG 342
Query: 357 TRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTES 416
+K+ +GLTG + F+ G R ++ +DV LK G K+G W+ L + +
Sbjct: 343 IDMERTLKQVRIQGLTGNVQFDH-YGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQD 401
Query: 417 QKGKPANITDSLSNRSLIVTTIL 439
N T ++ NR+++VTTI+
Sbjct: 402 VP-TLGNDTAAIENRTVVVTTIM 423
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,288,188
Number of Sequences: 37866
Number of extensions: 1379676
Number of successful extensions: 3134
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2883
Number of HSP's gapped (non-prelim): 66
length of query: 908
length of database: 18,247,518
effective HSP length: 111
effective length of query: 797
effective length of database: 14,044,392
effective search space: 11193380424
effective search space used: 11193380424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.