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Search of human proteins with 21361262
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
(545 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens] 1083 0.0
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens] 1033 0.0
gi|4826894 phosphodiesterase 1C [Homo sapiens] 739 0.0
gi|4505677 phosphodiesterase 1B [Homo sapiens] 618 e-177
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens] 247 2e-65
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens] 247 2e-65
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens] 237 2e-62
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens] 237 2e-62
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens] 237 2e-62
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens] 237 2e-62
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens] 235 9e-62
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens] 235 9e-62
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens] 235 9e-62
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens] 235 9e-62
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens] 234 2e-61
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens] 234 2e-61
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens] 234 2e-61
gi|70608155 phosphodiesterase 3A [Homo sapiens] 187 2e-47
gi|40254434 phosphodiesterase 3B [Homo sapiens] 183 4e-46
gi|9506959 phosphodiesterase 7B [Homo sapiens] 177 2e-44
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens] 173 4e-43
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens] 173 4e-43
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens] 171 2e-42
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens] 164 2e-40
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens] 164 2e-40
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens] 164 2e-40
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens] 164 2e-40
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens] 164 2e-40
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens] 158 1e-38
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens] 148 1e-35
>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
Length = 545
Score = 1083 bits (2800), Expect = 0.0
Identities = 545/545 (100%), Positives = 545/545 (100%)
Query: 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA 60
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
Sbjct: 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA 60
Query: 61 SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS 120
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
Sbjct: 61 SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS 120
Query: 121 IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI 180
IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
Sbjct: 121 IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI 180
Query: 181 YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI 240
YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
Sbjct: 181 YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI 240
Query: 241 MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM 300
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
Sbjct: 241 MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM 300
Query: 301 QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL 360
QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
Sbjct: 301 QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL 360
Query: 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420
ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
Sbjct: 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420
Query: 421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS 480
IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
Sbjct: 421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS 480
Query: 481 MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKH 540
MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKH
Sbjct: 481 MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKH 540
Query: 541 DETHS 545
DETHS
Sbjct: 541 DETHS 545
>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
Length = 535
Score = 1033 bits (2672), Expect = 0.0
Identities = 521/521 (100%), Positives = 521/521 (100%)
Query: 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA 60
MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
Sbjct: 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA 60
Query: 61 SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS 120
SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
Sbjct: 61 SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS 120
Query: 121 IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI 180
IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
Sbjct: 121 IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI 180
Query: 181 YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI 240
YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
Sbjct: 181 YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI 240
Query: 241 MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM 300
MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
Sbjct: 241 MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM 300
Query: 301 QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL 360
QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
Sbjct: 301 QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL 360
Query: 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420
ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
Sbjct: 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420
Query: 421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS 480
IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
Sbjct: 421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS 480
Query: 481 MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQ 521
MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQ
Sbjct: 481 MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQ 521
>gi|4826894 phosphodiesterase 1C [Homo sapiens]
Length = 634
Score = 739 bits (1908), Expect = 0.0
Identities = 375/554 (67%), Positives = 453/554 (81%), Gaps = 17/554 (3%)
Query: 1 MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGI---------LRCLVKQLERGDVNVVD 51
M S EIEE E+ + KYL EQ EK+W RL+G+ LR LVKQLERG+ +VVD
Sbjct: 1 MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD 60
Query: 52 LKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKK 111
LKKN+EYAA+VLE+VYIDETRRLLDTEDELSDIQ+D+VPSEVRDWLASTFTR+MGM ++
Sbjct: 61 LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR 120
Query: 112 PEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEAS 171
+EKP+F+SIVHAVQAGIFVERMYR+T +MVGL+YP AVI LKDVDKWSFDVF+LNEAS
Sbjct: 121 SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS 180
Query: 172 GEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTV 231
G+H+LKF+ YEL TRYDLI+RFKIP+S L++F EALEVGYSK+KNPYHNL+HAADVTQTV
Sbjct: 181 GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV 240
Query: 232 HYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENH 291
HY++ TG+ +WLTELEI A++F+AAIHDYEHTGTTNNFHIQTRSD AILYNDRSVLENH
Sbjct: 241 HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH 300
Query: 292 HVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE 350
H+SAAYRL+Q +EEMNILINLSKDDWR+ R LVIEMV++TDMS HFQQIK ++ +LQQPE
Sbjct: 301 HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE 360
Query: 351 GIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKS 410
I++ K +SL+LH ADISHPAK+W LH+RWTM+L+EEFF QGD+EAELGLPFSPLCDRKS
Sbjct: 361 AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS 420
Query: 411 TMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIAD 470
TMVAQSQ+GFIDFIVEPTF++LTD TEKIV PLI+E S+ + SS +I +D
Sbjct: 421 TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISS---SD 477
Query: 471 ALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNS 530
A +RS K S S+GS + S+ +VD KSFK +++ N+ERW+ + E K +
Sbjct: 478 A-KRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPK-EEKAKKEA 535
Query: 531 EDLVN--AEEKHDE 542
E+ AEE+ E
Sbjct: 536 EEKARLAAEEQQKE 549
>gi|4505677 phosphodiesterase 1B [Homo sapiens]
Length = 536
Score = 618 bits (1593), Expect = e-177
Identities = 307/515 (59%), Positives = 398/515 (77%), Gaps = 23/515 (4%)
Query: 8 IEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVY 67
+EE + + L ++KMW +L+ +LR +VKQLE G++N+ +LKKN+EY AS+LEAVY
Sbjct: 12 LEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVY 71
Query: 68 IDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQA 127
IDETR++LDTEDEL ++++D+VPSEVRDWLASTFT++ ++ EEKPKFRSIVHAVQA
Sbjct: 72 IDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQA 131
Query: 128 GIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRY 187
GIFVERM+R+TY VG Y AV+ LK++D W FDVF+LN+A+ +H+L+ +++EL TR+
Sbjct: 132 GIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRH 191
Query: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTEL 247
+LI+RFKIP L++F +ALE GY KYKNPYHN IHAADVTQTVH +L TG++H L+E+
Sbjct: 192 NLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEI 251
Query: 248 EILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNI 307
E+LA++FAAAIHDYEHTGTTN+FHIQT+S+ AI+YNDRSVLENHH+S+ +RLMQ++EMNI
Sbjct: 252 ELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNI 311
Query: 308 LINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADI 367
INL+KD++ +LR LVIEMVL+TDMS HFQQ+K ++ +LQQ E ID+ K +SL+LHAADI
Sbjct: 312 FINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADI 371
Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
SHP K W +H RWT ALMEEFF QGDKEAELGLPFSPLCDR ST+VAQSQIGFIDFIVEP
Sbjct: 372 SHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEP 431
Query: 428 TFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYS 487
TFS+LTD EK V PL +E SK++ ++ + G +
Sbjct: 432 TFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSL----------------DVEVGDPN 475
Query: 488 PDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQG 522
P D+ SF++ V IQ+NK++WKE AA G
Sbjct: 476 P-------DVVSFRSTWVKRIQENKQKWKERAASG 503
>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
Length = 809
Score = 247 bits (631), Expect = 2e-65
Identities = 139/383 (36%), Positives = 224/383 (58%), Gaps = 23/383 (6%)
Query: 72 RRLLDTE-DELSDIQTDSVPSEVRDWLASTFTRKM------GMTKKKPEEKPKFRSIVHA 124
+R+L+ E LS++ ++V +++++TF K T+K+ E+K + S +
Sbjct: 309 KRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISG 366
Query: 125 VQAGIFVERMYRKTYHMVGLAYPAAVIVT--LKDVDKWSFDVFALNEASGEHSLKFMIYE 182
V+ + + + G+ ++ L+DV+KW VF + E SG L +++
Sbjct: 367 VKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT 426
Query: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
+F DL+ FKIPV LIT+ LE Y YHN IHAADV Q+ H ++ +
Sbjct: 427 IFQERDLLKTFKIPVDTLITYLMTLEDHYHA-DVAYHNNIHAADVVQSTHVLLSTPALEA 485
Query: 243 WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQE 302
T+LEILA +FA+AIHD +H G +N F I T S++A++YND SVLENHH++ ++L+QE
Sbjct: 486 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE 545
Query: 303 EEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI------ 352
E +I NL+K + LR +VI++VL+TDMS H + +++ ++ + G+
Sbjct: 546 ENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 605
Query: 353 -DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKST 411
DR + + ++H AD+S+P K +L+ +WT +MEEFF QGD+E E G+ SP+CD+ +
Sbjct: 606 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 665
Query: 412 MVAQSQIGFIDFIVEPTFSLLTD 434
V +SQ+GFID+IV P + D
Sbjct: 666 SVEKSQVGFIDYIVHPLWETWAD 688
>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
Length = 673
Score = 247 bits (631), Expect = 2e-65
Identities = 139/383 (36%), Positives = 224/383 (58%), Gaps = 23/383 (6%)
Query: 72 RRLLDTE-DELSDIQTDSVPSEVRDWLASTFTRKM------GMTKKKPEEKPKFRSIVHA 124
+R+L+ E LS++ ++V +++++TF K T+K+ E+K + S +
Sbjct: 173 KRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISG 230
Query: 125 VQAGIFVERMYRKTYHMVGLAYPAAVIVT--LKDVDKWSFDVFALNEASGEHSLKFMIYE 182
V+ + + + G+ ++ L+DV+KW VF + E SG L +++
Sbjct: 231 VKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT 290
Query: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
+F DL+ FKIPV LIT+ LE Y YHN IHAADV Q+ H ++ +
Sbjct: 291 IFQERDLLKTFKIPVDTLITYLMTLEDHYHA-DVAYHNNIHAADVVQSTHVLLSTPALEA 349
Query: 243 WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQE 302
T+LEILA +FA+AIHD +H G +N F I T S++A++YND SVLENHH++ ++L+QE
Sbjct: 350 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE 409
Query: 303 EEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI------ 352
E +I NL+K + LR +VI++VL+TDMS H + +++ ++ + G+
Sbjct: 410 ENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 469
Query: 353 -DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKST 411
DR + + ++H AD+S+P K +L+ +WT +MEEFF QGD+E E G+ SP+CD+ +
Sbjct: 470 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 529
Query: 412 MVAQSQIGFIDFIVEPTFSLLTD 434
V +SQ+GFID+IV P + D
Sbjct: 530 SVEKSQVGFIDYIVHPLWETWAD 552
>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
Length = 825
Score = 237 bits (605), Expect = 2e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 368 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 426
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 427 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 486
Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 487 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 546
Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 547 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 598
>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
Length = 860
Score = 237 bits (605), Expect = 2e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 403 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 461
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 462 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 521
Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 522 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 581
Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 582 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 633
>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
Length = 886
Score = 237 bits (605), Expect = 2e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 429 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 487
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 488 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 547
Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 548 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 607
Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 608 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 659
>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
Length = 647
Score = 237 bits (605), Expect = 2e-62
Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L++++KW ++F +++ +G SL ++Y +F DL+ +F+IPV ++T+ LE Y
Sbjct: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 190 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 248
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T S++A++YND SVLENHH++ ++L+QE+ +I NLSK + LR +VI+MVL+TDMS
Sbjct: 249 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 308
Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
H + +++ ++ + G+ DR + + ++H AD+S+P K +L+ +WT
Sbjct: 309 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 368
Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
+M EFF QGD+E E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 369 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 420
>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 235 bits (599), Expect = 9e-62
Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L+D++KW ++F + S L ++Y +F DL+ F+I IT+ LE Y
Sbjct: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T S++A++YND SVLENHH++ ++L+QEE +I +NL+K + LR +VI+MVL+TDMS
Sbjct: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520
Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
H + +++ ++ + G+ DR + + ++H AD+S+P KS +L+ +WT
Sbjct: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580
Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
+MEEFF QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
Length = 721
Score = 235 bits (599), Expect = 9e-62
Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L+D++KW ++F + S L ++Y +F DL+ F+I IT+ LE Y
Sbjct: 327 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 386
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 387 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 445
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T S++A++YND SVLENHH++ ++L+QEE +I +NL+K + LR +VI+MVL+TDMS
Sbjct: 446 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 505
Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
H + +++ ++ + G+ DR + + ++H AD+S+P KS +L+ +WT
Sbjct: 506 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 565
Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
+MEEFF QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 566 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 617
>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
Length = 564
Score = 235 bits (599), Expect = 9e-62
Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L+D++KW ++F + S L ++Y +F DL+ F+I IT+ LE Y
Sbjct: 170 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 229
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 230 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 288
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T S++A++YND SVLENHH++ ++L+QEE +I +NL+K + LR +VI+MVL+TDMS
Sbjct: 289 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 348
Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
H + +++ ++ + G+ DR + + ++H AD+S+P KS +L+ +WT
Sbjct: 349 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 408
Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
+MEEFF QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 409 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 460
>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
Length = 736
Score = 235 bits (599), Expect = 9e-62
Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L+D++KW ++F + S L ++Y +F DL+ F+I IT+ LE Y
Sbjct: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
YHN +HAADV Q+ H ++ + T+LEILA +FAAAIHD +H G +N F I
Sbjct: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T S++A++YND SVLENHH++ ++L+QEE +I +NL+K + LR +VI+MVL+TDMS
Sbjct: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520
Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
H + +++ ++ + G+ DR + + ++H AD+S+P KS +L+ +WT
Sbjct: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580
Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
+MEEFF QGDKE E G+ SP+CD+ + V +SQ+GFID+IV P + D
Sbjct: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632
>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
Length = 606
Score = 234 bits (596), Expect = 2e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 144 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 203
Query: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 204 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 263
Query: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 264 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 322
Query: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 323 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 382
Query: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 383 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 442
Query: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 443 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 502
Query: 429 FSLLTD 434
+ D
Sbjct: 503 WETWAD 508
>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
Length = 680
Score = 234 bits (596), Expect = 2e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 218 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 277
Query: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 278 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 337
Query: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 338 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 396
Query: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 397 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 456
Query: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 457 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 516
Query: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 517 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 576
Query: 429 FSLLTD 434
+ D
Sbjct: 577 WETWAD 582
>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
Length = 712
Score = 234 bits (596), Expect = 2e-61
Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)
Query: 85 QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
+T ++V ++++ TF ++ + K EE P+ S + + + T
Sbjct: 250 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 309
Query: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
G+ + L+D +KW DVF + E SG L +I+ +F DL+ F+IP
Sbjct: 310 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 369
Query: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
L T+ LE G+ YHN +HAADV Q+ H ++ + T+LEILA +FA+AIH
Sbjct: 370 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 428
Query: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
D +H G +N F I T S++A++YND SVLENHH++ ++L+Q E +I NLS L
Sbjct: 429 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 488
Query: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
R +VI+MVL+TDMS H + +++ ++ + G+ DR + + ++H AD+S
Sbjct: 489 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 548
Query: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
+P K L+ +WT +M EFF QGD+E E GL SP+CD+ + V +SQ+GFID+I P
Sbjct: 549 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 608
Query: 429 FSLLTD 434
+ D
Sbjct: 609 WETWAD 614
>gi|70608155 phosphodiesterase 3A [Homo sapiens]
Length = 1141
Score = 187 bits (476), Expect = 2e-47
Identities = 117/328 (35%), Positives = 160/328 (48%), Gaps = 56/328 (17%)
Query: 154 LKDVDKWSFDVFALNEASGEHS---LKFMIYELFTRYDLINRFKIPVSCLITFAEALEVG 210
++ ++ W+F +F L E G L + Y LF L FKIP+ + + ALE+G
Sbjct: 686 MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745
Query: 211 YSKYKNPYHNLIHAADVTQTVHYIMLH---------------------TGIMHW------ 243
Y PYHN IHA DV V Y+ +G H
Sbjct: 746 YRDI--PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVF 803
Query: 244 -----------------LTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRS 286
+ LE++A+ AAA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 804 SKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRS 863
Query: 287 VLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNS 345
VLENHH +AA+ L M E N LINL +++ R LVIE +L+TD+ HF +
Sbjct: 864 VLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK 923
Query: 346 LQQPEGI------DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELG 399
+ GI DR + + ADI+ PAK +LH +WT ++ EF+ QGD+EA LG
Sbjct: 924 VNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG 983
Query: 400 LPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
LP SP DR + +A Q FI IV P
Sbjct: 984 LPISPFMDRSAPQLANLQESFISHIVGP 1011
>gi|40254434 phosphodiesterase 3B [Homo sapiens]
Length = 1112
Score = 183 bits (464), Expect = 4e-46
Identities = 117/330 (35%), Positives = 163/330 (49%), Gaps = 58/330 (17%)
Query: 154 LKDVDKWSFDVFALNEASGEHS---LKFMIYELFTRYDLINRFKIPVSCLITFAEALEVG 210
++ + W+F +F L E GE S L ++Y LF L+ FKIP + + ALE G
Sbjct: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730
Query: 211 YSKYKNPYHNLIHAADVTQTVHYI---------MLHTG------------IMHW------ 243
Y PYHN IHA DV V Y+ +H G I H
Sbjct: 731 YRDI--PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788
Query: 244 -----------------LTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRS 286
+ LE++A+ AAA+HDY+H G TN F + T + A+LYNDRS
Sbjct: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848
Query: 287 VLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIR-- 343
VLENHH ++A+ L + E N L++L +++ R LVIE +L+TD+ HF +
Sbjct: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908
Query: 344 ------NSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAE 397
N ++ DR + + ADI+ PAK LH +WT ++ EF+ QGD+EA
Sbjct: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968
Query: 398 LGLPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
LGLP SP DR S +A+ Q FI IV P
Sbjct: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGP 998
>gi|9506959 phosphodiesterase 7B [Homo sapiens]
Length = 450
Score = 177 bits (449), Expect = 2e-44
Identities = 105/339 (30%), Positives = 181/339 (53%), Gaps = 15/339 (4%)
Query: 98 ASTFTRKMGMTKKKPEEKPKFRSIVHAVQA--GIFVERMYRKTYHMVGLAYPAAVIVTLK 155
++T++ ++G TKKK + F+ HA + GI + H++ Y L
Sbjct: 56 STTYSGEIG-TKKKVKRLLSFQRYFHASRLLRGIIPQA----PLHLLDEDYLGQARHMLS 110
Query: 156 DVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYK 215
V W FD+F + + +SL ++ LF + LI+ FK+ + L F ++ Y +
Sbjct: 111 KVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHS-Q 169
Query: 216 NPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTR 275
NPYHN +HAADVTQ +H + + +LT L+I+ + AAA HD +H G F I+T
Sbjct: 170 NPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTN 229
Query: 276 SDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGH 335
+A LY + SVLENHH + +++E +L +L K+ +D+ + ++L+TD++
Sbjct: 230 HHLANLYQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQ 287
Query: 336 FQQIKNIR-----NSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFL 390
+ + ++ L+ + DR + + L ADI +P + W++ +W+ + EEF+
Sbjct: 288 NEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYR 347
Query: 391 QGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTF 429
QG+ E + L SPLC+++ + QIGF+ +IVEP F
Sbjct: 348 QGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLF 386
>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
Length = 783
Score = 173 bits (438), Expect = 4e-43
Identities = 94/307 (30%), Positives = 160/307 (52%), Gaps = 25/307 (8%)
Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
P + +++ + W FD+F L A+ L ++ ++F R+ + S L ++ +
Sbjct: 439 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 498
Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
+E Y NPYHN H+ADV Y + I L ++ +A + AA IHD +H G
Sbjct: 499 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 557
Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIE 325
TN+F S++AILYND +VLE+HH + A++L +++ NI N+ ++D+R LR +I+
Sbjct: 558 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 617
Query: 326 MVLSTDMSGHFQQIKNIRNSLQQPEGI----------------------DRAKTMSLILH 363
MVL+T+M+ HF+ + NS+ +P +R +++
Sbjct: 618 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 677
Query: 364 AADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFID 422
AD+S+P + + W + EE+F Q D+E + GLP P+ DR + + +SQI FID
Sbjct: 678 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 737
Query: 423 FIVEPTF 429
+ + F
Sbjct: 738 YFITDMF 744
>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
Length = 829
Score = 173 bits (438), Expect = 4e-43
Identities = 94/307 (30%), Positives = 160/307 (52%), Gaps = 25/307 (8%)
Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
P + +++ + W FD+F L A+ L ++ ++F R+ + S L ++ +
Sbjct: 485 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 544
Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
+E Y NPYHN H+ADV Y + I L ++ +A + AA IHD +H G
Sbjct: 545 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 603
Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIE 325
TN+F S++AILYND +VLE+HH + A++L +++ NI N+ ++D+R LR +I+
Sbjct: 604 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 663
Query: 326 MVLSTDMSGHFQQIKNIRNSLQQPEGI----------------------DRAKTMSLILH 363
MVL+T+M+ HF+ + NS+ +P +R +++
Sbjct: 664 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 723
Query: 364 AADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFID 422
AD+S+P + + W + EE+F Q D+E + GLP P+ DR + + +SQI FID
Sbjct: 724 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 783
Query: 423 FIVEPTF 429
+ + F
Sbjct: 784 YFITDMF 790
>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
Length = 456
Score = 171 bits (433), Expect = 2e-42
Identities = 95/282 (33%), Positives = 156/282 (55%), Gaps = 8/282 (2%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L+ V W+FD+F + + +SL + + LF+ + LI F + + L F ++ Y
Sbjct: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
+NPYHN +HAADVTQ +H + + + +T +IL + AAA HD +H G F I+
Sbjct: 182 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T +A LY + SVLENHH +A L++E + +L + + + + ++L+TD+S
Sbjct: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILATDIS 298
Query: 334 GHFQQIKNIRNSLQQ-----PEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
+ + R+ L + + R + + L ADI +P ++W+L +W+ + EEF
Sbjct: 299 RQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 358
Query: 389 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFS 430
F QGD E + L SPLCDR + +A QIGF+ ++VEP F+
Sbjct: 359 FHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFT 400
>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
Length = 838
Score = 164 bits (415), Expect = 2e-40
Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)
Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
P + L + + W F++F L + + L ++ ++F+R+ + + L + +
Sbjct: 497 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 556
Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
+E Y N YHN HAADV + + + L +L+ +A + AA +HD +H G
Sbjct: 557 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 615
Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
TN+F S++A+LYND +VLE+HH + A++L +++ + NI N+ ++ +R LR +I+
Sbjct: 616 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 675
Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
MVL+T+M+ HF+ + NS+ +P EG D + +++ AD+
Sbjct: 676 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 735
Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
++P + L W + EE+F Q D+E GLP P+ DR + + +SQI FID+ +
Sbjct: 736 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 795
Query: 427 PTF 429
F
Sbjct: 796 DMF 798
>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
Length = 865
Score = 164 bits (415), Expect = 2e-40
Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)
Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
P + L + + W F++F L + + L ++ ++F+R+ + + L + +
Sbjct: 524 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 583
Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
+E Y N YHN HAADV + + + L +L+ +A + AA +HD +H G
Sbjct: 584 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 642
Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
TN+F S++A+LYND +VLE+HH + A++L +++ + NI N+ ++ +R LR +I+
Sbjct: 643 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 702
Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
MVL+T+M+ HF+ + NS+ +P EG D + +++ AD+
Sbjct: 703 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 762
Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
++P + L W + EE+F Q D+E GLP P+ DR + + +SQI FID+ +
Sbjct: 763 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 822
Query: 427 PTF 429
F
Sbjct: 823 DMF 825
>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
Length = 830
Score = 164 bits (415), Expect = 2e-40
Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)
Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
P + L + + W F++F L + + L ++ ++F+R+ + + L + +
Sbjct: 489 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 548
Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
+E Y N YHN HAADV + + + L +L+ +A + AA +HD +H G
Sbjct: 549 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 607
Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
TN+F S++A+LYND +VLE+HH + A++L +++ + NI N+ ++ +R LR +I+
Sbjct: 608 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 667
Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
MVL+T+M+ HF+ + NS+ +P EG D + +++ AD+
Sbjct: 668 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 727
Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
++P + L W + EE+F Q D+E GLP P+ DR + + +SQI FID+ +
Sbjct: 728 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787
Query: 427 PTF 429
F
Sbjct: 788 DMF 790
>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
Length = 788
Score = 164 bits (415), Expect = 2e-40
Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)
Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
P + L + + W F++F L + + L ++ ++F+R+ + + L + +
Sbjct: 447 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 506
Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
+E Y N YHN HAADV + + + L +L+ +A + AA +HD +H G
Sbjct: 507 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 565
Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
TN+F S++A+LYND +VLE+HH + A++L +++ + NI N+ ++ +R LR +I+
Sbjct: 566 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 625
Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
MVL+T+M+ HF+ + NS+ +P EG D + +++ AD+
Sbjct: 626 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 685
Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
++P + L W + EE+F Q D+E GLP P+ DR + + +SQI FID+ +
Sbjct: 686 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 745
Query: 427 PTF 429
F
Sbjct: 746 DMF 748
>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
Length = 885
Score = 164 bits (415), Expect = 2e-40
Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)
Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
P + L + + W F++F L + + L ++ ++F+R+ + + L + +
Sbjct: 544 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 603
Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
+E Y N YHN HAADV + + + L +L+ +A + AA +HD +H G
Sbjct: 604 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 662
Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
TN+F S++A+LYND +VLE+HH + A++L +++ + NI N+ ++ +R LR +I+
Sbjct: 663 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 722
Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
MVL+T+M+ HF+ + NS+ +P EG D + +++ AD+
Sbjct: 723 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 782
Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
++P + L W + EE+F Q D+E GLP P+ DR + + +SQI FID+ +
Sbjct: 783 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 842
Query: 427 PTF 429
F
Sbjct: 843 DMF 845
>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
Length = 424
Score = 158 bits (400), Expect = 1e-38
Identities = 90/271 (33%), Positives = 147/271 (54%), Gaps = 8/271 (2%)
Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
L+ V W+FD+F + + +SL + + LF+ + LI F + + L F ++ Y
Sbjct: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207
Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
+NPYHN +HAADVTQ +H + + + +T +IL + AAA HD +H G F I+
Sbjct: 208 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266
Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
T +A LY + SVLENHH +A L++E + +L + + + + ++L+TD+S
Sbjct: 267 TNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILATDIS 324
Query: 334 GHFQQIKNIRNSLQQ-----PEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
+ + R+ L + + R + + L ADI +P ++W+L +W+ + EEF
Sbjct: 325 RQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 384
Query: 389 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIG 419
F QGD E + L SPLCDR + +A QIG
Sbjct: 385 FHQGDIEKKYHLGVSPLCDRHTESIANIQIG 415
>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
Length = 386
Score = 148 bits (374), Expect = 1e-35
Identities = 88/299 (29%), Positives = 158/299 (52%), Gaps = 18/299 (6%)
Query: 153 TLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYS 212
T++ + K +FDV+ L+ M ++L L+ F I +T L +
Sbjct: 45 TIEALRKPTFDVWLWEPNEMLSCLEHMYHDL----GLVRDFSINP---VTLRRWLFCVHD 97
Query: 213 KYKN-PYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFH 271
Y+N P+HN H V Q ++ ++ + ++ +IL ++ AA HD +H G N +
Sbjct: 98 NYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQ 157
Query: 272 IQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTD 331
I R+++A+ YND S LENHH + A++++ E E NI N+ D ++ +R +I ++L+TD
Sbjct: 158 INARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATD 217
Query: 332 MSGHFQQIKNIRNSLQQPEGIDRAKTMSL----ILHAADISHPAKSWKLHYRWTMALMEE 387
M+ H + + + + ++ + + M+L ++ DIS+ + ++ W L+EE
Sbjct: 218 MARHAEIMDSFKEKMENFD-YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEE 276
Query: 388 FFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEE 446
+F+Q D+E GLP +P DR A +QIGFI F++ P F +T + P++EE
Sbjct: 277 YFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTK-----LFPMVEE 330
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.131 0.376
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,257,899
Number of Sequences: 37866
Number of extensions: 739363
Number of successful extensions: 2401
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2177
Number of HSP's gapped (non-prelim): 103
length of query: 545
length of database: 18,247,518
effective HSP length: 107
effective length of query: 438
effective length of database: 14,195,856
effective search space: 6217784928
effective search space used: 6217784928
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.