Guide to the Human Genome
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Search of human proteins with 21361262

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
         (545 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]            1083   0.0  
gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]            1033   0.0  
gi|4826894 phosphodiesterase 1C [Homo sapiens]                        739   0.0  
gi|4505677 phosphodiesterase 1B [Homo sapiens]                        618   e-177
gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]            247   2e-65
gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]             247   2e-65
gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]            237   2e-62
gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]            237   2e-62
gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]            237   2e-62
gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]              237   2e-62
gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]             235   9e-62
gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]             235   9e-62
gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]             235   9e-62
gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]             235   9e-62
gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]      234   2e-61
gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]      234   2e-61
gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]      234   2e-61
gi|70608155 phosphodiesterase 3A [Homo sapiens]                       187   2e-47
gi|40254434 phosphodiesterase 3B [Homo sapiens]                       183   4e-46
gi|9506959 phosphodiesterase 7B [Homo sapiens]                        177   2e-44
gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]             173   4e-43
gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]             173   4e-43
gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]             171   2e-42
gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]             164   2e-40
gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]             164   2e-40
gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]             164   2e-40
gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]             164   2e-40
gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]             164   2e-40
gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]             158   1e-38
gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]             148   1e-35

>gi|21361262 phosphodiesterase 1A isoform 1 [Homo sapiens]
          Length = 545

 Score = 1083 bits (2800), Expect = 0.0
 Identities = 545/545 (100%), Positives = 545/545 (100%)

Query: 1   MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA 60
           MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
Sbjct: 1   MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA 60

Query: 61  SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS 120
           SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
Sbjct: 61  SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS 120

Query: 121 IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI 180
           IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
Sbjct: 121 IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI 180

Query: 181 YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI 240
           YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
Sbjct: 181 YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI 240

Query: 241 MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM 300
           MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
Sbjct: 241 MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM 300

Query: 301 QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL 360
           QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
Sbjct: 301 QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL 360

Query: 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420
           ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
Sbjct: 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420

Query: 421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS 480
           IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
Sbjct: 421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS 480

Query: 481 MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKH 540
           MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKH
Sbjct: 481 MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNSEDLVNAEEKH 540

Query: 541 DETHS 545
           DETHS
Sbjct: 541 DETHS 545


>gi|51102295 phosphodiesterase 1A isoform 2 [Homo sapiens]
          Length = 535

 Score = 1033 bits (2672), Expect = 0.0
 Identities = 521/521 (100%), Positives = 521/521 (100%)

Query: 1   MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA 60
           MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA
Sbjct: 1   MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAA 60

Query: 61  SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS 120
           SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS
Sbjct: 61  SVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRS 120

Query: 121 IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI 180
           IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI
Sbjct: 121 IVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMI 180

Query: 181 YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI 240
           YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI
Sbjct: 181 YELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGI 240

Query: 241 MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM 300
           MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM
Sbjct: 241 MHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLM 300

Query: 301 QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL 360
           QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL
Sbjct: 301 QEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSL 360

Query: 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420
           ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF
Sbjct: 361 ILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGF 420

Query: 421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS 480
           IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS
Sbjct: 421 IDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGS 480

Query: 481 MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQ 521
           MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQ
Sbjct: 481 MSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQ 521


>gi|4826894 phosphodiesterase 1C [Homo sapiens]
          Length = 634

 Score =  739 bits (1908), Expect = 0.0
 Identities = 375/554 (67%), Positives = 453/554 (81%), Gaps = 17/554 (3%)

Query: 1   MGSSATEIEELENTTFKYLTGEQTEKMWQRLKGI---------LRCLVKQLERGDVNVVD 51
           M S   EIEE E+ + KYL  EQ EK+W RL+G+         LR LVKQLERG+ +VVD
Sbjct: 1   MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVD 60

Query: 52  LKKNIEYAASVLEAVYIDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKK 111
           LKKN+EYAA+VLE+VYIDETRRLLDTEDELSDIQ+D+VPSEVRDWLASTFTR+MGM  ++
Sbjct: 61  LKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRR 120

Query: 112 PEEKPKFRSIVHAVQAGIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEAS 171
            +EKP+F+SIVHAVQAGIFVERMYR+T +MVGL+YP AVI  LKDVDKWSFDVF+LNEAS
Sbjct: 121 SDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEAS 180

Query: 172 GEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTV 231
           G+H+LKF+ YEL TRYDLI+RFKIP+S L++F EALEVGYSK+KNPYHNL+HAADVTQTV
Sbjct: 181 GDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTV 240

Query: 232 HYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENH 291
           HY++  TG+ +WLTELEI A++F+AAIHDYEHTGTTNNFHIQTRSD AILYNDRSVLENH
Sbjct: 241 HYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENH 300

Query: 292 HVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE 350
           H+SAAYRL+Q +EEMNILINLSKDDWR+ R LVIEMV++TDMS HFQQIK ++ +LQQPE
Sbjct: 301 HLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPE 360

Query: 351 GIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKS 410
            I++ K +SL+LH ADISHPAK+W LH+RWTM+L+EEFF QGD+EAELGLPFSPLCDRKS
Sbjct: 361 AIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKS 420

Query: 411 TMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIAD 470
           TMVAQSQ+GFIDFIVEPTF++LTD TEKIV PLI+E S+   +    SS  +I     +D
Sbjct: 421 TMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISS---SD 477

Query: 471 ALRRSNTKGSMSDGSYSPDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQGESDLHKNS 530
           A +RS  K S S+GS   + S+ +VD KSFK    +++  N+ERW+    + E    K +
Sbjct: 478 A-KRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPK-EEKAKKEA 535

Query: 531 EDLVN--AEEKHDE 542
           E+     AEE+  E
Sbjct: 536 EEKARLAAEEQQKE 549


>gi|4505677 phosphodiesterase 1B [Homo sapiens]
          Length = 536

 Score =  618 bits (1593), Expect = e-177
 Identities = 307/515 (59%), Positives = 398/515 (77%), Gaps = 23/515 (4%)

Query: 8   IEELENTTFKYLTGEQTEKMWQRLKGILRCLVKQLERGDVNVVDLKKNIEYAASVLEAVY 67
           +EE +  +   L    ++KMW +L+ +LR +VKQLE G++N+ +LKKN+EY AS+LEAVY
Sbjct: 12  LEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVY 71

Query: 68  IDETRRLLDTEDELSDIQTDSVPSEVRDWLASTFTRKMGMTKKKPEEKPKFRSIVHAVQA 127
           IDETR++LDTEDEL ++++D+VPSEVRDWLASTFT++     ++ EEKPKFRSIVHAVQA
Sbjct: 72  IDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQA 131

Query: 128 GIFVERMYRKTYHMVGLAYPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRY 187
           GIFVERM+R+TY  VG  Y  AV+  LK++D W FDVF+LN+A+ +H+L+ +++EL TR+
Sbjct: 132 GIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRH 191

Query: 188 DLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTEL 247
           +LI+RFKIP   L++F +ALE GY KYKNPYHN IHAADVTQTVH  +L TG++H L+E+
Sbjct: 192 NLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEI 251

Query: 248 EILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNI 307
           E+LA++FAAAIHDYEHTGTTN+FHIQT+S+ AI+YNDRSVLENHH+S+ +RLMQ++EMNI
Sbjct: 252 ELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNI 311

Query: 308 LINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPEGIDRAKTMSLILHAADI 367
            INL+KD++ +LR LVIEMVL+TDMS HFQQ+K ++ +LQQ E ID+ K +SL+LHAADI
Sbjct: 312 FINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADI 371

Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
           SHP K W +H RWT ALMEEFF QGDKEAELGLPFSPLCDR ST+VAQSQIGFIDFIVEP
Sbjct: 372 SHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEP 431

Query: 428 TFSLLTDSTEKIVIPLIEEASKAETSSYVASSSTTIVGLHIADALRRSNTKGSMSDGSYS 487
           TFS+LTD  EK V PL +E SK++          ++                 +  G  +
Sbjct: 432 TFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSL----------------DVEVGDPN 475

Query: 488 PDYSLAAVDLKSFKNNLVDIIQQNKERWKELAAQG 522
           P       D+ SF++  V  IQ+NK++WKE AA G
Sbjct: 476 P-------DVVSFRSTWVKRIQENKQKWKERAASG 503


>gi|157277988 phosphodiesterase 4D isoform 1 [Homo sapiens]
          Length = 809

 Score =  247 bits (631), Expect = 2e-65
 Identities = 139/383 (36%), Positives = 224/383 (58%), Gaps = 23/383 (6%)

Query: 72  RRLLDTE-DELSDIQTDSVPSEVRDWLASTFTRKM------GMTKKKPEEKPKFRSIVHA 124
           +R+L+ E   LS++      ++V +++++TF  K         T+K+ E+K +  S +  
Sbjct: 309 KRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISG 366

Query: 125 VQAGIFVERMYRKTYHMVGLAYPAAVIVT--LKDVDKWSFDVFALNEASGEHSLKFMIYE 182
           V+  +    +   +    G+      ++   L+DV+KW   VF + E SG   L  +++ 
Sbjct: 367 VKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT 426

Query: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
           +F   DL+  FKIPV  LIT+   LE  Y      YHN IHAADV Q+ H ++    +  
Sbjct: 427 IFQERDLLKTFKIPVDTLITYLMTLEDHYHA-DVAYHNNIHAADVVQSTHVLLSTPALEA 485

Query: 243 WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQE 302
             T+LEILA +FA+AIHD +H G +N F I T S++A++YND SVLENHH++  ++L+QE
Sbjct: 486 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE 545

Query: 303 EEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI------ 352
           E  +I  NL+K   + LR +VI++VL+TDMS H   + +++  ++  +    G+      
Sbjct: 546 ENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 605

Query: 353 -DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKST 411
            DR + +  ++H AD+S+P K  +L+ +WT  +MEEFF QGD+E E G+  SP+CD+ + 
Sbjct: 606 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 665

Query: 412 MVAQSQIGFIDFIVEPTFSLLTD 434
            V +SQ+GFID+IV P +    D
Sbjct: 666 SVEKSQVGFIDYIVHPLWETWAD 688


>gi|32306513 phosphodiesterase 4D isoform 2 [Homo sapiens]
          Length = 673

 Score =  247 bits (631), Expect = 2e-65
 Identities = 139/383 (36%), Positives = 224/383 (58%), Gaps = 23/383 (6%)

Query: 72  RRLLDTE-DELSDIQTDSVPSEVRDWLASTFTRKM------GMTKKKPEEKPKFRSIVHA 124
           +R+L+ E   LS++      ++V +++++TF  K         T+K+ E+K +  S +  
Sbjct: 173 KRMLNRELTHLSEMSRSG--NQVSEFISNTFLDKQHEVEIPSPTQKEKEKKKRPMSQISG 230

Query: 125 VQAGIFVERMYRKTYHMVGLAYPAAVIVT--LKDVDKWSFDVFALNEASGEHSLKFMIYE 182
           V+  +    +   +    G+      ++   L+DV+KW   VF + E SG   L  +++ 
Sbjct: 231 VKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHT 290

Query: 183 LFTRYDLINRFKIPVSCLITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMH 242
           +F   DL+  FKIPV  LIT+   LE  Y      YHN IHAADV Q+ H ++    +  
Sbjct: 291 IFQERDLLKTFKIPVDTLITYLMTLEDHYHA-DVAYHNNIHAADVVQSTHVLLSTPALEA 349

Query: 243 WLTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQE 302
             T+LEILA +FA+AIHD +H G +N F I T S++A++YND SVLENHH++  ++L+QE
Sbjct: 350 VFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQE 409

Query: 303 EEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI------ 352
           E  +I  NL+K   + LR +VI++VL+TDMS H   + +++  ++  +    G+      
Sbjct: 410 ENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNY 469

Query: 353 -DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKST 411
            DR + +  ++H AD+S+P K  +L+ +WT  +MEEFF QGD+E E G+  SP+CD+ + 
Sbjct: 470 SDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNA 529

Query: 412 MVAQSQIGFIDFIVEPTFSLLTD 434
            V +SQ+GFID+IV P +    D
Sbjct: 530 SVEKSQVGFIDYIVHPLWETWAD 552


>gi|162329612 phosphodiesterase 4A isoform 3 [Homo sapiens]
          Length = 825

 Score =  237 bits (605), Expect = 2e-62
 Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L++++KW  ++F +++ +G  SL  ++Y +F   DL+ +F+IPV  ++T+   LE  Y  
Sbjct: 308 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 367

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 368 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 426

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T S++A++YND SVLENHH++  ++L+QE+  +I  NLSK   + LR +VI+MVL+TDMS
Sbjct: 427 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 486

Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P K  +L+ +WT 
Sbjct: 487 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 546

Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
            +M EFF QGD+E E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 547 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 598


>gi|162329610 phosphodiesterase 4A isoform 2 [Homo sapiens]
          Length = 860

 Score =  237 bits (605), Expect = 2e-62
 Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L++++KW  ++F +++ +G  SL  ++Y +F   DL+ +F+IPV  ++T+   LE  Y  
Sbjct: 343 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 402

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 403 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 461

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T S++A++YND SVLENHH++  ++L+QE+  +I  NLSK   + LR +VI+MVL+TDMS
Sbjct: 462 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 521

Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P K  +L+ +WT 
Sbjct: 522 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 581

Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
            +M EFF QGD+E E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 582 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 633


>gi|162329608 phosphodiesterase 4A isoform 1 [Homo sapiens]
          Length = 886

 Score =  237 bits (605), Expect = 2e-62
 Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L++++KW  ++F +++ +G  SL  ++Y +F   DL+ +F+IPV  ++T+   LE  Y  
Sbjct: 369 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 428

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 429 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 487

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T S++A++YND SVLENHH++  ++L+QE+  +I  NLSK   + LR +VI+MVL+TDMS
Sbjct: 488 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 547

Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P K  +L+ +WT 
Sbjct: 548 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 607

Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
            +M EFF QGD+E E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 608 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 659


>gi|5453862 phosphodiesterase 4A isoform 4 [Homo sapiens]
          Length = 647

 Score =  237 bits (605), Expect = 2e-62
 Identities = 117/292 (40%), Positives = 187/292 (64%), Gaps = 12/292 (4%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L++++KW  ++F +++ +G  SL  ++Y +F   DL+ +F+IPV  ++T+   LE  Y  
Sbjct: 130 LENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHA 189

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 190 -DVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLIN 248

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T S++A++YND SVLENHH++  ++L+QE+  +I  NLSK   + LR +VI+MVL+TDMS
Sbjct: 249 TNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMS 308

Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P K  +L+ +WT 
Sbjct: 309 KHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTD 368

Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
            +M EFF QGD+E E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 369 RIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 420


>gi|82799486 phosphodiesterase 4B isoform 1 [Homo sapiens]
          Length = 736

 Score =  235 bits (599), Expect = 9e-62
 Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L+D++KW  ++F +   S    L  ++Y +F   DL+  F+I     IT+   LE  Y  
Sbjct: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T S++A++YND SVLENHH++  ++L+QEE  +I +NL+K   + LR +VI+MVL+TDMS
Sbjct: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520

Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P KS +L+ +WT 
Sbjct: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580

Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
            +MEEFF QGDKE E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632


>gi|82799484 phosphodiesterase 4B isoform 3 [Homo sapiens]
          Length = 721

 Score =  235 bits (599), Expect = 9e-62
 Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L+D++KW  ++F +   S    L  ++Y +F   DL+  F+I     IT+   LE  Y  
Sbjct: 327 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 386

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 387 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 445

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T S++A++YND SVLENHH++  ++L+QEE  +I +NL+K   + LR +VI+MVL+TDMS
Sbjct: 446 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 505

Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P KS +L+ +WT 
Sbjct: 506 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 565

Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
            +MEEFF QGDKE E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 566 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 617


>gi|82799482 phosphodiesterase 4B isoform 2 [Homo sapiens]
          Length = 564

 Score =  235 bits (599), Expect = 9e-62
 Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L+D++KW  ++F +   S    L  ++Y +F   DL+  F+I     IT+   LE  Y  
Sbjct: 170 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 229

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 230 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 288

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T S++A++YND SVLENHH++  ++L+QEE  +I +NL+K   + LR +VI+MVL+TDMS
Sbjct: 289 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 348

Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P KS +L+ +WT 
Sbjct: 349 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 408

Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
            +MEEFF QGDKE E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 409 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 460


>gi|32171241 phosphodiesterase 4B isoform 1 [Homo sapiens]
          Length = 736

 Score =  235 bits (599), Expect = 9e-62
 Identities = 119/292 (40%), Positives = 182/292 (62%), Gaps = 12/292 (4%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L+D++KW  ++F +   S    L  ++Y +F   DL+  F+I     IT+   LE  Y  
Sbjct: 342 LEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHS 401

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
               YHN +HAADV Q+ H ++    +    T+LEILA +FAAAIHD +H G +N F I 
Sbjct: 402 -DVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLIN 460

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T S++A++YND SVLENHH++  ++L+QEE  +I +NL+K   + LR +VI+MVL+TDMS
Sbjct: 461 TNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMS 520

Query: 334 GHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADISHPAKSWKLHYRWTM 382
            H   + +++  ++  +    G+       DR + +  ++H AD+S+P KS +L+ +WT 
Sbjct: 521 KHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTD 580

Query: 383 ALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTD 434
            +MEEFF QGDKE E G+  SP+CD+ +  V +SQ+GFID+IV P +    D
Sbjct: 581 RIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWAD 632


>gi|149363666 phosphodiesterase 4C isoform PDE4C-2 [Homo sapiens]
          Length = 606

 Score =  234 bits (596), Expect = 2e-61
 Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)

Query: 85  QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
           +T    ++V ++++ TF     ++ + K   EE P+  S +  +        +   T   
Sbjct: 144 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 203

Query: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
            G+       +   L+D +KW  DVF + E SG   L  +I+ +F   DL+  F+IP   
Sbjct: 204 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 263

Query: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
           L T+   LE G+      YHN +HAADV Q+ H ++    +    T+LEILA +FA+AIH
Sbjct: 264 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 322

Query: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
           D +H G +N F I T S++A++YND SVLENHH++  ++L+Q E  +I  NLS      L
Sbjct: 323 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 382

Query: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
           R +VI+MVL+TDMS H   + +++  ++  +    G+       DR + +  ++H AD+S
Sbjct: 383 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 442

Query: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
           +P K   L+ +WT  +M EFF QGD+E E GL  SP+CD+ +  V +SQ+GFID+I  P 
Sbjct: 443 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 502

Query: 429 FSLLTD 434
           +    D
Sbjct: 503 WETWAD 508


>gi|149363646 phosphodiesterase 4C isoform PDE4C-3 [Homo sapiens]
          Length = 680

 Score =  234 bits (596), Expect = 2e-61
 Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)

Query: 85  QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
           +T    ++V ++++ TF     ++ + K   EE P+  S +  +        +   T   
Sbjct: 218 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 277

Query: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
            G+       +   L+D +KW  DVF + E SG   L  +I+ +F   DL+  F+IP   
Sbjct: 278 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 337

Query: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
           L T+   LE G+      YHN +HAADV Q+ H ++    +    T+LEILA +FA+AIH
Sbjct: 338 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 396

Query: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
           D +H G +N F I T S++A++YND SVLENHH++  ++L+Q E  +I  NLS      L
Sbjct: 397 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 456

Query: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
           R +VI+MVL+TDMS H   + +++  ++  +    G+       DR + +  ++H AD+S
Sbjct: 457 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 516

Query: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
           +P K   L+ +WT  +M EFF QGD+E E GL  SP+CD+ +  V +SQ+GFID+I  P 
Sbjct: 517 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 576

Query: 429 FSLLTD 434
           +    D
Sbjct: 577 WETWAD 582


>gi|115529445 phosphodiesterase 4C isoform PDE4C-1 [Homo sapiens]
          Length = 712

 Score =  234 bits (596), Expect = 2e-61
 Identities = 130/366 (35%), Positives = 204/366 (55%), Gaps = 17/366 (4%)

Query: 85  QTDSVPSEVRDWLASTFT---RKMGMTKKKPEEKPKFRSIVHAVQAGIFVERMYRKTYHM 141
           +T    ++V ++++ TF     ++ + K   EE P+  S +  +        +   T   
Sbjct: 250 ETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSASLSSATVPR 309

Query: 142 VGLA--YPAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSC 199
            G+       +   L+D +KW  DVF + E SG   L  +I+ +F   DL+  F+IP   
Sbjct: 310 FGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLLKTFQIPADT 369

Query: 200 LITFAEALEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIH 259
           L T+   LE G+      YHN +HAADV Q+ H ++    +    T+LEILA +FA+AIH
Sbjct: 370 LATYLLMLE-GHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILAALFASAIH 428

Query: 260 DYEHTGTTNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDL 319
           D +H G +N F I T S++A++YND SVLENHH++  ++L+Q E  +I  NLS      L
Sbjct: 429 DVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNLSAKQRLSL 488

Query: 320 RNLVIEMVLSTDMSGHFQQIKNIRNSLQQPE----GI-------DRAKTMSLILHAADIS 368
           R +VI+MVL+TDMS H   + +++  ++  +    G+       DR + +  ++H AD+S
Sbjct: 489 RRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQNLVHCADLS 548

Query: 369 HPAKSWKLHYRWTMALMEEFFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPT 428
           +P K   L+ +WT  +M EFF QGD+E E GL  SP+CD+ +  V +SQ+GFID+I  P 
Sbjct: 549 NPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPL 608

Query: 429 FSLLTD 434
           +    D
Sbjct: 609 WETWAD 614


>gi|70608155 phosphodiesterase 3A [Homo sapiens]
          Length = 1141

 Score =  187 bits (476), Expect = 2e-47
 Identities = 117/328 (35%), Positives = 160/328 (48%), Gaps = 56/328 (17%)

Query: 154  LKDVDKWSFDVFALNEASGEHS---LKFMIYELFTRYDLINRFKIPVSCLITFAEALEVG 210
            ++ ++ W+F +F L E  G      L  + Y LF    L   FKIP+   + +  ALE+G
Sbjct: 686  MEQLNTWNFPIFDLVENIGRKCGRILSQVSYRLFEDMGLFEAFKIPIREFMNYFHALEIG 745

Query: 211  YSKYKNPYHNLIHAADVTQTVHYIMLH---------------------TGIMHW------ 243
            Y     PYHN IHA DV   V Y+                        +G  H       
Sbjct: 746  YRDI--PYHNRIHATDVLHAVWYLTTQPIPGLSTVINDHGSTSDSDSDSGFTHGHMGYVF 803

Query: 244  -----------------LTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRS 286
                             +  LE++A+  AAA+HDY+H G TN F + T +  A+LYNDRS
Sbjct: 804  SKTYNVTDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRS 863

Query: 287  VLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIRNS 345
            VLENHH +AA+ L M   E N LINL   +++  R LVIE +L+TD+  HF  +      
Sbjct: 864  VLENHHAAAAWNLFMSRPEYNFLINLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNGK 923

Query: 346  LQQPEGI------DRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELG 399
            +    GI      DR     + +  ADI+ PAK  +LH +WT  ++ EF+ QGD+EA LG
Sbjct: 924  VNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLQWTDGIVNEFYEQGDEEASLG 983

Query: 400  LPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
            LP SP  DR +  +A  Q  FI  IV P
Sbjct: 984  LPISPFMDRSAPQLANLQESFISHIVGP 1011


>gi|40254434 phosphodiesterase 3B [Homo sapiens]
          Length = 1112

 Score =  183 bits (464), Expect = 4e-46
 Identities = 117/330 (35%), Positives = 163/330 (49%), Gaps = 58/330 (17%)

Query: 154 LKDVDKWSFDVFALNEASGEHS---LKFMIYELFTRYDLINRFKIPVSCLITFAEALEVG 210
           ++ +  W+F +F L E  GE S   L  ++Y LF    L+  FKIP    + +  ALE G
Sbjct: 671 IEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENG 730

Query: 211 YSKYKNPYHNLIHAADVTQTVHYI---------MLHTG------------IMHW------ 243
           Y     PYHN IHA DV   V Y+          +H G            I H       
Sbjct: 731 YRDI--PYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYIS 788

Query: 244 -----------------LTELEILAMVFAAAIHDYEHTGTTNNFHIQTRSDVAILYNDRS 286
                            +  LE++A+  AAA+HDY+H G TN F + T +  A+LYNDRS
Sbjct: 789 SKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRS 848

Query: 287 VLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGHFQQIKNIR-- 343
           VLENHH ++A+ L +   E N L++L   +++  R LVIE +L+TD+  HF  +      
Sbjct: 849 VLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAK 908

Query: 344 ------NSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFLQGDKEAE 397
                 N ++     DR     + +  ADI+ PAK   LH +WT  ++ EF+ QGD+EA 
Sbjct: 909 ANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEAN 968

Query: 398 LGLPFSPLCDRKSTMVAQSQIGFIDFIVEP 427
           LGLP SP  DR S  +A+ Q  FI  IV P
Sbjct: 969 LGLPISPFMDRSSPQLAKLQESFITHIVGP 998


>gi|9506959 phosphodiesterase 7B [Homo sapiens]
          Length = 450

 Score =  177 bits (449), Expect = 2e-44
 Identities = 105/339 (30%), Positives = 181/339 (53%), Gaps = 15/339 (4%)

Query: 98  ASTFTRKMGMTKKKPEEKPKFRSIVHAVQA--GIFVERMYRKTYHMVGLAYPAAVIVTLK 155
           ++T++ ++G TKKK +    F+   HA +   GI  +       H++   Y       L 
Sbjct: 56  STTYSGEIG-TKKKVKRLLSFQRYFHASRLLRGIIPQA----PLHLLDEDYLGQARHMLS 110

Query: 156 DVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSKYK 215
            V  W FD+F  +  +  +SL  ++  LF  + LI+ FK+ +  L  F   ++  Y   +
Sbjct: 111 KVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHS-Q 169

Query: 216 NPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQTR 275
           NPYHN +HAADVTQ +H  +    +  +LT L+I+  + AAA HD +H G    F I+T 
Sbjct: 170 NPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTN 229

Query: 276 SDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMSGH 335
             +A LY + SVLENHH  +   +++E    +L +L K+  +D+   +  ++L+TD++  
Sbjct: 230 HHLANLYQNMSVLENHHWRSTIGMLRES--RLLAHLPKEMTQDIEQQLGSLILATDINRQ 287

Query: 336 FQQIKNIR-----NSLQQPEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEFFL 390
            + +  ++       L+  +  DR   + + L  ADI +P + W++  +W+  + EEF+ 
Sbjct: 288 NEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYR 347

Query: 391 QGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTF 429
           QG+ E +  L  SPLC+++   +   QIGF+ +IVEP F
Sbjct: 348 QGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLF 386


>gi|47132537 phosphodiesterase 8A isoform 2 [Homo sapiens]
          Length = 783

 Score =  173 bits (438), Expect = 4e-43
 Identities = 94/307 (30%), Positives = 160/307 (52%), Gaps = 25/307 (8%)

Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
           P  +   +++ + W FD+F L  A+    L ++  ++F R+ +        S L ++ + 
Sbjct: 439 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 498

Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
           +E  Y    NPYHN  H+ADV     Y +    I   L  ++ +A + AA IHD +H G 
Sbjct: 499 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 557

Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIE 325
           TN+F     S++AILYND +VLE+HH + A++L   +++ NI  N+ ++D+R LR  +I+
Sbjct: 558 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 617

Query: 326 MVLSTDMSGHFQQIKNIRNSLQQPEGI----------------------DRAKTMSLILH 363
           MVL+T+M+ HF+ +    NS+ +P                         +R     +++ 
Sbjct: 618 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 677

Query: 364 AADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFID 422
            AD+S+P +  +    W   + EE+F Q D+E + GLP   P+ DR +  + +SQI FID
Sbjct: 678 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 737

Query: 423 FIVEPTF 429
           + +   F
Sbjct: 738 YFITDMF 744


>gi|27734721 phosphodiesterase 8A isoform 1 [Homo sapiens]
          Length = 829

 Score =  173 bits (438), Expect = 4e-43
 Identities = 94/307 (30%), Positives = 160/307 (52%), Gaps = 25/307 (8%)

Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
           P  +   +++ + W FD+F L  A+    L ++  ++F R+ +        S L ++ + 
Sbjct: 485 PPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQI 544

Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
           +E  Y    NPYHN  H+ADV     Y +    I   L  ++ +A + AA IHD +H G 
Sbjct: 545 IEANYHS-SNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGR 603

Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRLMQ-EEEMNILINLSKDDWRDLRNLVIE 325
           TN+F     S++AILYND +VLE+HH + A++L   +++ NI  N+ ++D+R LR  +I+
Sbjct: 604 TNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIID 663

Query: 326 MVLSTDMSGHFQQIKNIRNSLQQPEGI----------------------DRAKTMSLILH 363
           MVL+T+M+ HF+ +    NS+ +P                         +R     +++ 
Sbjct: 664 MVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIK 723

Query: 364 AADISHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFID 422
            AD+S+P +  +    W   + EE+F Q D+E + GLP   P+ DR +  + +SQI FID
Sbjct: 724 CADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFID 783

Query: 423 FIVEPTF 429
           + +   F
Sbjct: 784 YFITDMF 790


>gi|24429566 phosphodiesterase 7A isoform a [Homo sapiens]
          Length = 456

 Score =  171 bits (433), Expect = 2e-42
 Identities = 95/282 (33%), Positives = 156/282 (55%), Gaps = 8/282 (2%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L+ V  W+FD+F  +  +  +SL  + + LF+ + LI  F + +  L  F   ++  Y  
Sbjct: 122 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 181

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
            +NPYHN +HAADVTQ +H  +    + + +T  +IL  + AAA HD +H G    F I+
Sbjct: 182 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 240

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T   +A LY + SVLENHH  +A  L++E    +  +L  +  + +   +  ++L+TD+S
Sbjct: 241 TNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILATDIS 298

Query: 334 GHFQQIKNIRNSLQQ-----PEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
              + +   R+ L +      +   R   + + L  ADI +P ++W+L  +W+  + EEF
Sbjct: 299 RQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 358

Query: 389 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFS 430
           F QGD E +  L  SPLCDR +  +A  QIGF+ ++VEP F+
Sbjct: 359 FHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFT 400


>gi|71164875 phosphodiesterase 8B isoform 2 [Homo sapiens]
          Length = 838

 Score =  164 bits (415), Expect = 2e-40
 Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)

Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
           P  +   L + + W F++F L   + +  L ++  ++F+R+ +        + L  + + 
Sbjct: 497 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 556

Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
           +E  Y    N YHN  HAADV     + +    +   L +L+ +A + AA +HD +H G 
Sbjct: 557 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 615

Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
           TN+F     S++A+LYND +VLE+HH + A++L +++ + NI  N+ ++ +R LR  +I+
Sbjct: 616 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 675

Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
           MVL+T+M+ HF+ +    NS+ +P     EG D             +     +++  AD+
Sbjct: 676 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 735

Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
           ++P +   L   W   + EE+F Q D+E   GLP   P+ DR +  + +SQI FID+ + 
Sbjct: 736 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 795

Query: 427 PTF 429
             F
Sbjct: 796 DMF 798


>gi|71164873 phosphodiesterase 8B isoform 4 [Homo sapiens]
          Length = 865

 Score =  164 bits (415), Expect = 2e-40
 Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)

Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
           P  +   L + + W F++F L   + +  L ++  ++F+R+ +        + L  + + 
Sbjct: 524 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 583

Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
           +E  Y    N YHN  HAADV     + +    +   L +L+ +A + AA +HD +H G 
Sbjct: 584 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 642

Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
           TN+F     S++A+LYND +VLE+HH + A++L +++ + NI  N+ ++ +R LR  +I+
Sbjct: 643 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 702

Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
           MVL+T+M+ HF+ +    NS+ +P     EG D             +     +++  AD+
Sbjct: 703 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 762

Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
           ++P +   L   W   + EE+F Q D+E   GLP   P+ DR +  + +SQI FID+ + 
Sbjct: 763 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 822

Query: 427 PTF 429
             F
Sbjct: 823 DMF 825


>gi|71164869 phosphodiesterase 8B isoform 5 [Homo sapiens]
          Length = 830

 Score =  164 bits (415), Expect = 2e-40
 Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)

Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
           P  +   L + + W F++F L   + +  L ++  ++F+R+ +        + L  + + 
Sbjct: 489 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 548

Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
           +E  Y    N YHN  HAADV     + +    +   L +L+ +A + AA +HD +H G 
Sbjct: 549 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 607

Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
           TN+F     S++A+LYND +VLE+HH + A++L +++ + NI  N+ ++ +R LR  +I+
Sbjct: 608 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 667

Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
           MVL+T+M+ HF+ +    NS+ +P     EG D             +     +++  AD+
Sbjct: 668 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 727

Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
           ++P +   L   W   + EE+F Q D+E   GLP   P+ DR +  + +SQI FID+ + 
Sbjct: 728 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 787

Query: 427 PTF 429
             F
Sbjct: 788 DMF 790


>gi|71164867 phosphodiesterase 8B isoform 3 [Homo sapiens]
          Length = 788

 Score =  164 bits (415), Expect = 2e-40
 Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)

Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
           P  +   L + + W F++F L   + +  L ++  ++F+R+ +        + L  + + 
Sbjct: 447 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 506

Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
           +E  Y    N YHN  HAADV     + +    +   L +L+ +A + AA +HD +H G 
Sbjct: 507 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 565

Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
           TN+F     S++A+LYND +VLE+HH + A++L +++ + NI  N+ ++ +R LR  +I+
Sbjct: 566 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 625

Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
           MVL+T+M+ HF+ +    NS+ +P     EG D             +     +++  AD+
Sbjct: 626 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 685

Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
           ++P +   L   W   + EE+F Q D+E   GLP   P+ DR +  + +SQI FID+ + 
Sbjct: 686 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 745

Query: 427 PTF 429
             F
Sbjct: 746 DMF 748


>gi|26006851 phosphodiesterase 8B isoform 1 [Homo sapiens]
          Length = 885

 Score =  164 bits (415), Expect = 2e-40
 Identities = 90/303 (29%), Positives = 160/303 (52%), Gaps = 21/303 (6%)

Query: 147 PAAVIVTLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEA 206
           P  +   L + + W F++F L   + +  L ++  ++F+R+ +        + L  + + 
Sbjct: 544 PPCISQLLDNEESWDFNIFELEAITHKRPLVYLGLKVFSRFGVCEFLNCSETTLRAWFQV 603

Query: 207 LEVGYSKYKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGT 266
           +E  Y    N YHN  HAADV     + +    +   L +L+ +A + AA +HD +H G 
Sbjct: 604 IEANYHS-SNAYHNSTHAADVLHATAFFLGKERVKGSLDQLDEVAALIAATVHDVDHPGR 662

Query: 267 TNNFHIQTRSDVAILYNDRSVLENHHVSAAYRL-MQEEEMNILINLSKDDWRDLRNLVIE 325
           TN+F     S++A+LYND +VLE+HH + A++L +++ + NI  N+ ++ +R LR  +I+
Sbjct: 663 TNSFLCNAGSELAVLYNDTAVLESHHTALAFQLTVKDTKCNIFKNIDRNHYRTLRQAIID 722

Query: 326 MVLSTDMSGHFQQIKNIRNSLQQP-----EGID-------------RAKTMSLILHAADI 367
           MVL+T+M+ HF+ +    NS+ +P     EG D             +     +++  AD+
Sbjct: 723 MVLATEMTKHFEHVNKFVNSINKPMAAEIEGSDCECNPAGKNFPENQILIKRMMIKCADV 782

Query: 368 SHPAKSWKLHYRWTMALMEEFFLQGDKEAELGLP-FSPLCDRKSTMVAQSQIGFIDFIVE 426
           ++P +   L   W   + EE+F Q D+E   GLP   P+ DR +  + +SQI FID+ + 
Sbjct: 783 ANPCRPLDLCIEWAGRISEEYFAQTDEEKRQGLPVVMPVFDRNTCSIPKSQISFIDYFIT 842

Query: 427 PTF 429
             F
Sbjct: 843 DMF 845


>gi|24429564 phosphodiesterase 7A isoform b [Homo sapiens]
          Length = 424

 Score =  158 bits (400), Expect = 1e-38
 Identities = 90/271 (33%), Positives = 147/271 (54%), Gaps = 8/271 (2%)

Query: 154 LKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYSK 213
           L+ V  W+FD+F  +  +  +SL  + + LF+ + LI  F + +  L  F   ++  Y  
Sbjct: 148 LEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHS 207

Query: 214 YKNPYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFHIQ 273
            +NPYHN +HAADVTQ +H  +    + + +T  +IL  + AAA HD +H G    F I+
Sbjct: 208 -QNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIK 266

Query: 274 TRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTDMS 333
           T   +A LY + SVLENHH  +A  L++E    +  +L  +  + +   +  ++L+TD+S
Sbjct: 267 TNHYLATLYKNTSVLENHHWRSAVGLLRES--GLFSHLPLESRQQMETQIGALILATDIS 324

Query: 334 GHFQQIKNIRNSLQQ-----PEGIDRAKTMSLILHAADISHPAKSWKLHYRWTMALMEEF 388
              + +   R+ L +      +   R   + + L  ADI +P ++W+L  +W+  + EEF
Sbjct: 325 RQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEF 384

Query: 389 FLQGDKEAELGLPFSPLCDRKSTMVAQSQIG 419
           F QGD E +  L  SPLCDR +  +A  QIG
Sbjct: 385 FHQGDIEKKYHLGVSPLCDRHTESIANIQIG 415


>gi|48762752 phosphodiesterase 9A isoform g [Homo sapiens]
          Length = 386

 Score =  148 bits (374), Expect = 1e-35
 Identities = 88/299 (29%), Positives = 158/299 (52%), Gaps = 18/299 (6%)

Query: 153 TLKDVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLITFAEALEVGYS 212
           T++ + K +FDV+          L+ M ++L     L+  F I     +T    L   + 
Sbjct: 45  TIEALRKPTFDVWLWEPNEMLSCLEHMYHDL----GLVRDFSINP---VTLRRWLFCVHD 97

Query: 213 KYKN-PYHNLIHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNFH 271
            Y+N P+HN  H   V Q ++ ++    +    ++ +IL ++ AA  HD +H G  N + 
Sbjct: 98  NYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQ 157

Query: 272 IQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILINLSKDDWRDLRNLVIEMVLSTD 331
           I  R+++A+ YND S LENHH + A++++ E E NI  N+  D ++ +R  +I ++L+TD
Sbjct: 158 INARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATD 217

Query: 332 MSGHFQQIKNIRNSLQQPEGIDRAKTMSL----ILHAADISHPAKSWKLHYRWTMALMEE 387
           M+ H + + + +  ++  +     + M+L    ++   DIS+  +  ++   W   L+EE
Sbjct: 218 MARHAEIMDSFKEKMENFD-YSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEE 276

Query: 388 FFLQGDKEAELGLPFSPLCDRKSTMVAQSQIGFIDFIVEPTFSLLTDSTEKIVIPLIEE 446
           +F+Q D+E   GLP +P  DR     A +QIGFI F++ P F  +T      + P++EE
Sbjct: 277 YFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTK-----LFPMVEE 330


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.131    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,257,899
Number of Sequences: 37866
Number of extensions: 739363
Number of successful extensions: 2401
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 2177
Number of HSP's gapped (non-prelim): 103
length of query: 545
length of database: 18,247,518
effective HSP length: 107
effective length of query: 438
effective length of database: 14,195,856
effective search space: 6217784928
effective search space used: 6217784928
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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