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Search of human proteins with 21314671
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21314671 transient receptor potential cation channel,
subfamily M, member 4 [Homo sapiens]
(1214 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21314671 transient receptor potential cation channel, subfami... 2463 0.0
gi|11225266 transient receptor potential cation channel, subfami... 919 0.0
gi|4507689 transient receptor potential cation channel, subfamil... 721 0.0
gi|109689695 transient receptor potential cation channel, subfam... 576 e-164
gi|154091314 transient receptor potential cation channel, subfam... 507 e-143
gi|154091320 transient receptor potential cation channel, subfam... 474 e-133
gi|154091318 transient receptor potential cation channel, subfam... 474 e-133
gi|154091316 transient receptor potential cation channel, subfam... 473 e-133
gi|154091312 transient receptor potential cation channel, subfam... 473 e-133
gi|154091308 transient receptor potential cation channel, subfam... 467 e-131
gi|154091310 transient receptor potential cation channel, subfam... 467 e-131
gi|18921093 transient receptor potential cation channel, subfami... 465 e-130
gi|94538366 transient receptor potential cation channel, subfami... 313 6e-85
gi|148612863 transient receptor potential cation channel, subfam... 255 2e-67
gi|45935368 transient receptor potential cation channel, subfami... 136 1e-31
gi|55953096 transient receptor potential cation channel, subfami... 129 1e-29
gi|209863032 transient receptor potential cation channel, subfam... 65 5e-10
gi|209863030 transient receptor potential cation channel, subfam... 65 5e-10
gi|209863026 transient receptor potential cation channel, subfam... 65 5e-10
gi|209863024 transient receptor potential cation channel, subfam... 65 5e-10
gi|7706747 transient receptor potential cation channel, subfamil... 65 5e-10
gi|6912736 transient receptor potential cation channel, subfamil... 57 8e-08
gi|209863028 transient receptor potential cation channel, subfam... 50 2e-05
gi|194733735 transient receptor potential cation channel, subfam... 45 5e-04
gi|4507687 transient receptor potential cation channel, subfamil... 45 5e-04
gi|4507685 transient receptor potential cation channel, subfamil... 44 0.001
gi|21735483 transient receptor potential cation channel, subfami... 42 0.004
gi|9966865 transient receptor potential cation channel, subfamil... 41 0.008
gi|5730102 transient receptor potential cation channel, subfamil... 40 0.013
gi|20127551 transient receptor potential cation channel, subfami... 39 0.039
>gi|21314671 transient receptor potential cation channel, subfamily M,
member 4 [Homo sapiens]
Length = 1214
Score = 2463 bits (6383), Expect = 0.0
Identities = 1214/1214 (100%), Positives = 1214/1214 (100%)
Query: 1 MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTV 60
MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTV
Sbjct: 1 MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTV 60
Query: 61 WDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVS 120
WDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVS
Sbjct: 61 WDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVS 120
Query: 121 VLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGG 180
VLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGG
Sbjct: 121 VLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGG 180
Query: 181 TKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTH 240
TKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTH
Sbjct: 181 TKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTH 240
Query: 241 GCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLL 300
GCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLL
Sbjct: 241 GCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLL 300
Query: 301 VAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKEL 360
VAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKEL
Sbjct: 301 VAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKEL 360
Query: 361 LTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQW 420
LTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQW
Sbjct: 361 LTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQW 420
Query: 421 RSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQA 480
RSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQA
Sbjct: 421 RSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQA 480
Query: 481 SHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLL 540
SHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLL
Sbjct: 481 SHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLL 540
Query: 541 SDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMA 600
SDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMA
Sbjct: 541 SDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMA 600
Query: 601 RLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQ 660
RLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQ
Sbjct: 601 RLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQ 660
Query: 661 ADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTRE 720
ADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTRE
Sbjct: 661 ADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTRE 720
Query: 721 ELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPV 780
ELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPV
Sbjct: 721 ELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPV 780
Query: 781 TIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSL 840
TIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSL
Sbjct: 781 TIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSL 840
Query: 841 ASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFM 900
ASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFM
Sbjct: 841 ASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFM 900
Query: 901 VFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFP 960
VFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFP
Sbjct: 901 VFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFP 960
Query: 961 SILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLV 1020
SILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLV
Sbjct: 961 SILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLV 1020
Query: 1021 VLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFI 1080
VLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFI
Sbjct: 1021 VLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFI 1080
Query: 1081 VISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDK 1140
VISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDK
Sbjct: 1081 VISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDK 1140
Query: 1141 RESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLP 1200
RESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLP
Sbjct: 1141 RESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLP 1200
Query: 1201 PGGPPPPDLPGSKD 1214
PGGPPPPDLPGSKD
Sbjct: 1201 PGGPPPPDLPGSKD 1214
>gi|11225266 transient receptor potential cation channel, subfamily M,
member 5 [Homo sapiens]
Length = 1165
Score = 919 bits (2375), Expect = 0.0
Identities = 523/1148 (45%), Positives = 700/1148 (60%), Gaps = 63/1148 (5%)
Query: 76 GELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQ 135
GE++F G+G+K F+R+ P+ ++ L+ W APNLVVS++G +++WL+
Sbjct: 26 GEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLR 85
Query: 136 DLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGG-TKVVAMGVAPWGVV 194
D+LR+GLV+AAQSTGAWI+T L G+ RHVG AVRDH +AST +VVA+G+A G V
Sbjct: 86 DVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRV 145
Query: 195 RNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLE 254
+R L + FP Y G LD N S F LV+ G G G RLRLE
Sbjct: 146 LHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLE 205
Query: 255 SYISQQKTGVGGTG-IDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAE 313
+IS+Q+ G GGTG I+IPVL LL++GD L RI A + P L++ GSGG AD LA
Sbjct: 206 KHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAA 265
Query: 314 TLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVYSSE-DGSEE 372
+ A + + F D+ ++ I + + LLTVY E +GSEE
Sbjct: 266 LVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEE 325
Query: 373 FETIVLKALVKACGS--SEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLM 430
+T++LKALVKAC S E YLDEL+LAVAW+RVDIA+SE+F GD++W+S LE ++
Sbjct: 326 LDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMV 385
Query: 431 DALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQASHSAGTKAPA 490
DAL++++PEFVRL + +G + FLT RL +LY + SL+ +LL + A
Sbjct: 386 DALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEARLTLAG 445
Query: 491 LKGGAAELRPP----------DVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLL 540
L G + R P +V VL+ L C Y G D + G +
Sbjct: 446 L--GTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEK-GPAKRPT 502
Query: 541 SDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMA 600
K L+ + + PW DL LWA+L NR +MA YFW MG V++AL AC +L+ M+
Sbjct: 503 GQKWLLDLNQKS---ENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMS 559
Query: 601 RLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQ 660
LE +AE A ++ K+E + +DLF ECY +SE RA LL+RR W TCL LA +
Sbjct: 560 HLETEAEAARATREA--KYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATE 617
Query: 661 ADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTRE 720
ADA+AFFA DGVQ+ LT+ WWGDMA+ TPI L+ AF CP L+YT LITF SEE P R
Sbjct: 618 ADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITF--SEEAPLRT 675
Query: 721 ELEF--DMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGA 778
LE D+DS+ + P+ + + PR G G L RW FWGA
Sbjct: 676 GLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGP-----RAVFLLTRWRKFWGA 730
Query: 779 PVTIFMGNVVSYLLFLLLFSRVLLVDFQPAP--PGSLELLLYFWAFTLLCEELRQGLSGG 836
PVT+F+GNVV Y FL LF+ VLLVDF+P P P E+ LYFW FTL+ EE+RQG
Sbjct: 731 PVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTD 790
Query: 837 GGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLC 896
+ L ++ LY+ D+WN+CD+VA+ F++GV CR+ P + GRTVL
Sbjct: 791 EDT-----------HLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLA 839
Query: 897 IDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRD 956
+DFMVFT+RL+HIF ++KQLGPKI++V +MMKDVFFFLFFL VWLVAYGV T+ LL P D
Sbjct: 840 MDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHD 899
Query: 957 SDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYA 1016
I RRV YRPYLQIFGQIP +++D A + NCS+ P P +C S YA
Sbjct: 900 GRLEWIFRRVLYRPYLQIFGQIPLDEIDEARV---NCSTHPLLLEDSP-----SCPSLYA 951
Query: 1017 NWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALA 1076
NWLV+LLLV FLLV N+LL+NLLIAMFSYTF VQGN+D++WK QRY LI E+H RPALA
Sbjct: 952 NWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALA 1011
Query: 1077 PPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLAR 1136
PPFI++SHL L LR++ ++ + EH L ++K++TWE+V KENFL
Sbjct: 1012 PPFILLSHLSLTLRRVFKK-----EAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKM 1066
Query: 1137 ARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRS 1196
+ +R+S+ E L++T+ +VD K LG +RE E+R+K LE ++ CS ++ VA+ L++
Sbjct: 1067 EKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQG 1126
Query: 1197 ALLPPGGP 1204
GGP
Sbjct: 1127 -----GGP 1129
>gi|4507689 transient receptor potential cation channel, subfamily M,
member 2 [Homo sapiens]
Length = 1503
Score = 721 bits (1862), Expect = 0.0
Identities = 440/1221 (36%), Positives = 653/1221 (53%), Gaps = 105/1221 (8%)
Query: 5 EKEQSWIPKIFKKKTCTTFIVDS--TDPGGTLCQCGRPRTAHPAVAMEDAFGAAVV--TV 60
E SWIP+ KKK C F+ S +D G +CQCG H +E+A T
Sbjct: 57 ESLSSWIPENIKKKECVYFVESSKLSDAGKVVCQCGYTHEQH----LEEATKPHTFQGTQ 112
Query: 61 WDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVS 120
WD H E PTDA+G++ FTG +K ++R+S T + +Y L+T+ WG PNL++S
Sbjct: 113 WDPKKHVQEMPTDAFGDIVFTGLSQKVKKYVRVSQDTPSSVIYHLMTQHWGLDVPNLLIS 172
Query: 121 VLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMAST-G 179
V GG+ ++ L+ + RRGLV+ AQ+TGAWI+TGG HTG+ + VG AVRD ++S+
Sbjct: 173 VTGGAKNFNMKPRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVGEAVRDFSLSSSYK 232
Query: 180 GTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGT 239
+++ +GVA WG V R+ LI+P GSFPA Y D + + LD N+S F LVDDGT
Sbjct: 233 EGELITIGVATWGTVHRREGLIHPTGSFPAEYILDEDGQGNLTC-LDSNHSHFILVDDGT 291
Query: 240 HGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCL 299
HG G E R RLE +IS+Q GG I IP++ ++++G L I+NAT PC+
Sbjct: 292 HGQYGVEIPLRTRLEKFISEQTKERGGVAIKIPIVCVVLEGGPGTLHTIDNATTNGTPCV 351
Query: 300 LVAGSGGAADCLAETLEDTLAPGSGGARQGEAR---DRIRRFFPKGDLEVLQAQVERIMT 356
+V GSG AD +A+ ++ + Q + + F + + +++ I+
Sbjct: 352 VVEGSGRVADVIAQVANLPVSDITISLIQQKLSVFFQEMFETFTESRIVEWTKKIQDIVR 411
Query: 357 RKELLTVY-SSEDGSEEFETIVLKALVKACGSSEASAYLD---ELRLAVAWNRVDIAQSE 412
R++LLTV+ +DG ++ + +L+AL+KA S + + + +L+LAVAWNRVDIA+SE
Sbjct: 412 RRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHENWDHQLKLAVAWNRVDIARSE 471
Query: 413 LFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSL 472
+F + QW+ L ++ AL++++PEFV+L + +G+ L F+T L LY + L
Sbjct: 472 IFMDEWQWKPSDLHPTMTAALISNKPEFVKLFLENGVQLKEFVTWDTLLYLYENLDPSCL 531
Query: 473 IRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWD------ 526
+ L Q + PA A L+ V VLR LLG P YP D
Sbjct: 532 FHSKL-QKVLVEDPERPACAPAAPRLQMHHVAQVLRELLGDFTQPLYPRPRHNDRLRLLL 590
Query: 527 --PHPGQGF-GESMYLLSDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGS 583
PH G S+ L +++ ++ P DLL+WA++ NR ++A W
Sbjct: 591 PVPHVKLNVQGVSLRSLYKRSSGHVTFT----MDPIRDLLIWAIVQNRRELAGIIWAQSQ 646
Query: 584 NAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLL 643
+ +++AL +L+ +++ E D + + LA ++E + +F ECYR E RA +LL
Sbjct: 647 DCIAAALACSKILKELSKEEEDTDSSEEMLALAEEYEHRAIGVFTECYRKDEERAQKLLT 706
Query: 644 RRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLI 703
R WG TCLQLA++A F + G+Q+ LT+ WWG ++ +W + L PL+
Sbjct: 707 RVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTKVWWGQLSVDNGLWRVTLCMLAFPLL 766
Query: 704 YTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRC 763
T LI+FR+ + +G P R
Sbjct: 767 LTGLISFREKRLQ-----------------------------DVGTPAARARA------- 790
Query: 764 GGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFT 823
F+ APV +F N++SY FL LF+ VL+VDFQP P E +Y W F+
Sbjct: 791 -----------FFTAPVVVFHLNILSYFAFLCLFAYVLMVDFQPV-PSWCECAIYLWLFS 838
Query: 824 LLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL 883
L+CEE+RQ P L ++ LY +D WN+ D+ A+ F+ G+ CRL
Sbjct: 839 LVCEEMRQLFY-----------DPDECGLMKKAALYFSDFWNKLDVGAILLFVAGLTCRL 887
Query: 884 TPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVA 943
P + GR +L +DF++F +RL+HIFT++K LGPKI+IV +MMKDVFFFLF L VW+V+
Sbjct: 888 IPATLYPGRVILSLDFILFCLRLMHIFTISKTLGPKIIIVKRMMKDVFFFLFLLAVWVVS 947
Query: 944 YGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVAL-MEHSNCSSEPGFWAH 1002
+GVA + +L + + R Y YL IFGQIP V EH + + +
Sbjct: 948 FGVAKQAILIHNERRVDWLFRGAVYHSYLTIFGQIPGYIDGVNFNPEHCSPNGTDPYKPK 1007
Query: 1003 PPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQR 1062
P + A + WL VLLL ++LL NILL+NLLIAMF+YTF +VQ ++D WK QR
Sbjct: 1008 CPESDATQQRPAFPEWLTVLLLCLYLLFTNILLLNLLIAMFNYTFQQVQEHTDQIWKFQR 1067
Query: 1063 YRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEH--FRVYLSKEAERK 1120
+ LI E+H RPA PPFI++SHL+L ++++ + +PA H + L K E
Sbjct: 1068 HDLIEEYHGRPAAPPPFILLSHLQLFIKRVVLK-------TPAKRHKQLKNKLEKNEEAA 1120
Query: 1121 LLTWESVHKENFLLARARDKRESDSERLKRTSQKVD-----LALKQLGHIREYEQRLKVL 1175
LL+WE KEN+L R +++ ++++ S KVD L L L EQRL L
Sbjct: 1121 LLSWEIYLKENYLQNRQFQQKQRPEQKIEDISNKVDAMVDLLDLDPLKRSGSMEQRLASL 1180
Query: 1176 EREVQQCSRVLGWVAEALSRS 1196
E +V Q +R L W+ L S
Sbjct: 1181 EEQVAQTARALHWIVRTLRAS 1201
>gi|109689695 transient receptor potential cation channel, subfamily
M, member 8 [Homo sapiens]
Length = 1104
Score = 576 bits (1484), Expect = e-164
Identities = 382/1185 (32%), Positives = 609/1185 (51%), Gaps = 143/1185 (12%)
Query: 9 SWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAV--VTVWDSDAH 66
++I FKK+ C F DS +C+CG ++ H ME G + W+ H
Sbjct: 43 NFIQANFKKRECVFFTKDSKATEN-VCKCGYAQSQH----ME---GTQINQSEKWNYKKH 94
Query: 67 TTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSG 126
T E PTDA+G++ F G+K ++RLS TD +Y L+T+ W + PNLV+SV GG+
Sbjct: 95 TKEFPTDAFGDIQFETLGKK-GKYIRLSCDTDAEILYELLTQHWHLKTPNLVISVTGGAK 153
Query: 127 GPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAM 186
L+ ++ + R L+ AQS GAWI+TGG H G+ +++G VRD+ ++ + +VA+
Sbjct: 154 NFALKPRMRKIFSR-LIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRSSEENIVAI 212
Query: 187 GVAPWGVVRNRDTLI---NPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCL 243
G+A WG+V NRDTLI + +G F A+Y D + + LD N++ LVD+G HG
Sbjct: 213 GIAAWGMVSNRDTLIRNCDAEGYFLAQYLMDDFTRDPL-YILDNNHTHLLLVDNGCHGHP 271
Query: 244 GGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAG 303
E + R +LE YIS++ G IP++ G ++ L I + + ++PC++V G
Sbjct: 272 TVEAKLRNQLEKYISERTIQDSNYGGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEG 331
Query: 304 SGGAADCLAETLEDTLAPGSGGARQGEAR--DRIRRFFPKGDLEVLQAQVERIMTRKELL 361
SG AD +A +E A S ++ R R P+ + E ++ I+ LL
Sbjct: 332 SGQIADVIASLVEVEDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLL 391
Query: 362 TVYSSEDGSEEFETIVLK-ALVKACGSSEASA--YLDELRLAVAWNRVDIAQSELFRGDI 418
TV E+ +E + + AL KA +SE + +L+L + WN++D+A E+F D
Sbjct: 392 TVIKMEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDEIFTNDR 451
Query: 419 QWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLD 478
+W S L+ + AL+ DRP+FVRL + +GL+L FLT L +L+S S + RNL
Sbjct: 452 RWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTELFSNHFSTLVYRNL-- 509
Query: 479 QASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMY 538
++ L + K+ A + +GF +
Sbjct: 510 ------------------QIAKNSYNDALLTFVWKLVA-----------NFRRGFRKEDR 540
Query: 539 LLSDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRV 598
D+ L + + + P L +WA+L N+ +++ WE +ALGA LL+
Sbjct: 541 NGRDEMDIELHDVSPITRHPLQALFIWAILQNKKELSKVIWEQTRGCTLAALGASKLLKT 600
Query: 599 MARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLA 658
+A+++ D A ++LA ++E V+LF ECY S E A +LL+ C WG + CL+LA
Sbjct: 601 LAKVKNDINAAGESEELANEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELA 660
Query: 659 MQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPT 718
++A + F AQ GVQ+ L+++W+G+++ T W ++L F PL+ ++FRK
Sbjct: 661 VEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKK----- 715
Query: 719 REELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGA 778
P +K ++ L + F+ +
Sbjct: 716 ----------------------PVDK--------------------HKKLLWYYVAFFTS 733
Query: 779 PVTIFMGNVVSYLLFLLLFSRVLLVDFQ--PAPPGSLELLLYFWAFTLLCEELRQGLSGG 836
P +F NVV Y+ FLLLF+ VLL+DF P PP EL+LY F L C+E+RQ G
Sbjct: 734 PFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPP---ELVLYSLVFVLFCDEVRQWYVNG 790
Query: 837 GGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL---TPGLYHLGRT 893
Y D WN D + L F+ G+ RL + GR
Sbjct: 791 VN--------------------YFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRV 830
Query: 894 VLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLR 953
+ C+D+++FT+RL+HIFTV++ LGPKI+++ +M+ DVFFFLF VW+VA+GVA +G+LR
Sbjct: 831 IFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILR 890
Query: 954 PRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGT-CV 1012
+ + I R V Y PYL +FGQ+P D+D + ++C+ G + P + +
Sbjct: 891 QNEQRWRWIFRSVIYEPYLAMFGQVP-SDVDGTTYDFAHCTF-TGNESKPLCVELDEHNL 948
Query: 1013 SQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSR 1072
++ W+ + L+ I++L NILLVNLL+AMF YT G VQ N+D WK QRY L++E+ SR
Sbjct: 949 PRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGTVQENNDQVWKFQRYFLVQEYCSR 1008
Query: 1073 PALAPPFIVISHLRLLLR---QLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHK 1129
+ PFIV ++ ++++ + C + ++ + S V K + + L WE V K
Sbjct: 1009 LNIPFPFIVFAYFYMVVKKCFKCCCKEKNMESS--------VCCFKNEDNETLAWEGVMK 1060
Query: 1130 ENFLLARARDKRESDSERLKRTSQKVDLALKQL-GHIREYEQRLK 1173
EN+L+ + K SE ++ +++D L L G ++E ++K
Sbjct: 1061 ENYLV-KINTKANDTSEEMRHRFRQLDTKLNDLKGLLKEIANKIK 1104
>gi|154091314 transient receptor potential cation channel, subfamily
M, member 3 isoform k [Homo sapiens]
Length = 1707
Score = 507 bits (1306), Expect = e-143
Identities = 378/1256 (30%), Positives = 629/1256 (50%), Gaps = 114/1256 (9%)
Query: 7 EQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAH----PAVAM------EDAFGAA 56
++SWI + F K+ C I + DP C CGR H P++++ E
Sbjct: 61 QKSWIERAFYKRECVHIIPSTKDPHR--CCCGRLIGQHVGLTPSISVLQNEKNESRLSRN 118
Query: 57 VVTV--WDSDAHTTEKPTDAYGELDFTGAGRKHSN---FLRLSDRTDPAAVYSLVTRTWG 111
+ W HT PTDA+G ++F G G HSN ++R+S T P + L+T+ W
Sbjct: 119 DIQSEKWSISKHTQLSPTDAFGTIEFQGGG--HSNKAMYVRVSFDTKPDLLLHLMTKEWQ 176
Query: 112 FRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVR 171
P L++SV GG LQ L+ + +GL++AA +TGAWI TGG++TG+ RHVG A++
Sbjct: 177 LELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWIFTGGVNTGVIRHVGDALK 236
Query: 172 DHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSA 231
DH S G K+ +G+APWG+V N++ LI P Y+ +P + L+ +S
Sbjct: 237 DHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP--YQTMSNPMSKLTV-LNSMHSH 291
Query: 232 FFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENA 291
F L D+GT G G E + R +LE +IS QK G +PV+ L+++G +++ +
Sbjct: 292 FILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-IGQGVPVVALIVEGGPNVISIVLEY 350
Query: 292 TQ--AQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRI-----RRF-FPKGD 343
+ +P ++ GSG A+D LA + + GG RD++ + F + +
Sbjct: 351 LRDTPPVPVVVCDGSGRASDILAFGHKYS---EEGGLINESLRDQLLVTIQKTFTYTRTQ 407
Query: 344 LEVLQAQVERIMTRKELLTVYS-SEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVA 402
+ L + M +KEL+TV+ +G ++ + +L AL+K +S D+L LA+A
Sbjct: 408 AQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGANASAP----DQLSLALA 463
Query: 403 WNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQ 462
WNRVDIA+S++F QW LE +++DAL+ DR +FV+LLI +G+S+ FLT RL +
Sbjct: 464 WNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEE 523
Query: 463 LYSA--APSNSLIRNLLDQASHSA-----------GTKAPALKGGAAELRPPDVGHVLRM 509
LY+ PSN+L + D + G L GGA R R
Sbjct: 524 LYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLMGGA--YRCNYTRKRFRT 581
Query: 510 LLGKMCAPRYPSG----GAWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPWS--DLL 563
L + P+ P G D P + ++ ++ L D + P+ +L+
Sbjct: 582 LYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDLD-DPEINHFPFPFHELM 640
Query: 564 LWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFK----- 618
+WA+L+ R +MA++FW+ G A++ AL AC L + MA +A E D++ +
Sbjct: 641 VWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAH---EASENDMVDDISQELNHNS 697
Query: 619 --FEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLL 676
F + V+L + Y+ E A +LL W +ATCLQLA+ A R F A Q LL
Sbjct: 698 RDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLL 757
Query: 677 TQKWWGDMASTTPIWA-LVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGP 735
T W G + ++L PP I + + F+ ++ P + + E P
Sbjct: 758 TDMWMGRLRMRKNSGLKVILGILLPPSILS--LEFKNKDDMPYMSQAQEIHLQEKEAEEP 815
Query: 736 VGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCL----------RRWFHFWGAPVTIFMG 785
E+ + + GR R + R+ + F+ AP+ F
Sbjct: 816 EKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWF 875
Query: 786 NVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGP 845
++Y+ +L+LF+ ++LV + P + E ++ + FTL E++R+ L G L
Sbjct: 876 YTLAYIGYLMLFNYIVLVKMERWP-STQEWIVISYIFTLGIEKMREILMSEPGKLL---- 930
Query: 846 GPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHL-GRTVLCIDFMVFTV 904
Q+++++L + WN DL+A+ F +G+ RL + GR + C++ + + +
Sbjct: 931 --------QKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYI 982
Query: 905 RLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILR 964
RLL IF VNK LGP ++++ KMM D+ +F+ + V L+++GVA + +L P + + +
Sbjct: 983 RLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAK 1042
Query: 965 RVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLL 1024
+FY PY I+G++ + +D + N + E G P + G W+V ++
Sbjct: 1043 NIFYMPYWMIYGEVFADQIDPPCGQ--NETREDGKIIQLPPCKTGA-------WIVPAIM 1093
Query: 1025 VIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISH 1084
+LLVANILLVNLLIA+F+ TF +V+ S+ WK QRY+LI FH RP L PP I+ SH
Sbjct: 1094 ACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSH 1153
Query: 1085 LRLLLRQLCRRPRSPQPSSPALEH-FRVYLSKEAERKLLTWESVHKENFLLARARDKRES 1143
+ ++ + LC R R + ++ +++++ + +K+ +E E + + S
Sbjct: 1154 MTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSS 1213
Query: 1144 DSERLKRTSQKVDLALKQLGHIREYEQRLK----VLEREVQQCSRVLGWVAEALSR 1195
+ ER++ TS++V+ +L + E E +K ++ + Q ++G +A AL R
Sbjct: 1214 NDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALER 1269
>gi|154091320 transient receptor potential cation channel, subfamily
M, member 3 isoform a [Homo sapiens]
Length = 1554
Score = 474 bits (1219), Expect = e-133
Identities = 348/1158 (30%), Positives = 586/1158 (50%), Gaps = 95/1158 (8%)
Query: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
Query: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGI 269
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK G
Sbjct: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-IGQ 175
Query: 270 DIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAGSGGAADCLAETLEDTLAPGSGGAR 327
+PV+ L+++G +++ + + +P ++ GSG A+D LA + + GG
Sbjct: 176 GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYS---EEGGLI 232
Query: 328 QGEARDRI-----RRF-FPKGDLEVLQAQVERIMTRKELLTVYS-SEDGSEEFETIVLKA 380
RD++ + F + + + L + M +KEL+TV+ +G ++ + +L A
Sbjct: 233 NESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTA 292
Query: 381 LVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEF 440
L+K +S D+L LA+AWNRVDIA+S++F QW LE +++DAL+ DR +F
Sbjct: 293 LLKGANASAP----DQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDF 348
Query: 441 VRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASHSA-----------GTK 487
V+LLI +G+S+ FLT RL +LY+ PSN+L + D + G
Sbjct: 349 VKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLV 408
Query: 488 APALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSG----GAWDPHPGQGFGESMYLLSDK 543
L GGA R R L + P+ P G D P + ++ ++
Sbjct: 409 IEYLMGGA--YRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEE 466
Query: 544 ATSPLSLDAGLGQAPWS--DLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMAR 601
L D + P+ +L++WA+L+ R +MA++FW+ G A++ AL AC L + MA
Sbjct: 467 VDIDLD-DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAH 525
Query: 602 LEPDAEEAARRKDLAFK-------FEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATC 654
+A E D++ + F + V+L + Y+ E A +LL W +ATC
Sbjct: 526 ---EASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATC 582
Query: 655 LQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWA-LVLAFFCPPLIYTRLITFRKS 713
LQLA+ A R F A Q LLT W G + ++L PP I + + F+
Sbjct: 583 LQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILS--LEFKNK 640
Query: 714 EEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCL---- 769
++ P + + E P E+ + + GR R +
Sbjct: 641 DDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKH 700
Query: 770 ------RRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFT 823
R+ + F+ AP+ F ++Y+ +L+LF+ ++LV + P + E ++ + FT
Sbjct: 701 RLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP-STQEWIVISYIFT 759
Query: 824 LLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL 883
L E++R+ L G L Q+++++L + WN DL+A+ F +G+ RL
Sbjct: 760 LGIEKMREILMSEPGKLL------------QKVKVWLQEYWNVTDLIAILLFSVGMILRL 807
Query: 884 TPGLYHL-GRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLV 942
+ GR + C++ + + +RLL IF VNK LGP ++++ KMM D+ +F+ + V L+
Sbjct: 808 QDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLM 867
Query: 943 AYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAH 1002
++GVA + +L P + + + +FY PY I+G++ + +D + N + E G
Sbjct: 868 SFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQ--NETREDGKIIQ 925
Query: 1003 PPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQR 1062
P + G W+V ++ +LLVANILLVNLLIA+F+ TF +V+ S+ WK QR
Sbjct: 926 LPPCKTGA-------WIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQR 978
Query: 1063 YRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEH-FRVYLSKEAERKL 1121
Y+LI FH RP L PP I+ SH+ ++ + LC R R + ++ +++++ + +K+
Sbjct: 979 YQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKV 1038
Query: 1122 LTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLK----VLER 1177
+E E + + S+ ER++ TS++V+ +L + E E +K ++
Sbjct: 1039 HDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDI 1098
Query: 1178 EVQQCSRVLGWVAEALSR 1195
+ Q ++G +A AL R
Sbjct: 1099 RLAQLEDLIGRMATALER 1116
>gi|154091318 transient receptor potential cation channel, subfamily
M, member 3 isoform d [Homo sapiens]
Length = 1544
Score = 474 bits (1219), Expect = e-133
Identities = 346/1154 (29%), Positives = 586/1154 (50%), Gaps = 97/1154 (8%)
Query: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
Query: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGI 269
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK G
Sbjct: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-IGQ 175
Query: 270 DIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAGSGGAADCLAETLEDTLAPGSGGAR 327
+PV+ L+++G +++ + + +P ++ GSG A+D LA + + GG
Sbjct: 176 GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYS---EEGGLI 232
Query: 328 QGEARDRI-----RRF-FPKGDLEVLQAQVERIMTRKELLTVYS-SEDGSEEFETIVLKA 380
RD++ + F + + + L + M +KEL+TV+ +G ++ + +L A
Sbjct: 233 NESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTA 292
Query: 381 LVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEF 440
L+K +S D+L LA+AWNRVDIA+S++F QW LE +++DAL+ DR +F
Sbjct: 293 LLKGANASAP----DQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDF 348
Query: 441 VRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASHSAGTKAPALKGGAAEL 498
V+LLI +G+S+ FLT RL +LY+ PSN+L + D G P + +
Sbjct: 349 VKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKK---GNLPPDYR-----I 400
Query: 499 RPPDVGHVLRMLLGKMCAPRYPS-----------GGAWDPHPGQGFGESMYLLSDKATSP 547
D+G V+ L+G Y G D P + ++ ++
Sbjct: 401 SLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTKKREEEVDID 460
Query: 548 LSLDAGLGQAPWS--DLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPD 605
L D + P+ +L++WA+L+ R +MA++FW+ G A++ AL AC L + MA +
Sbjct: 461 LD-DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAH---E 516
Query: 606 AEEAARRKDLAFK-------FEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLA 658
A E D++ + F + V+L + Y+ E A +LL W +ATCLQLA
Sbjct: 517 ASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLA 576
Query: 659 MQADARAFFAQDGVQSLLTQKWWGDMASTTPIWA-LVLAFFCPPLIYTRLITFRKSEEEP 717
+ A R F A Q LLT W G + ++L PP I + + F+ ++ P
Sbjct: 577 VAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILS--LEFKNKDDMP 634
Query: 718 TREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCL-------- 769
+ + E P E+ + + GR R +
Sbjct: 635 YMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEVQSKHRLIP 694
Query: 770 --RRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCE 827
R+ + F+ AP+ F ++Y+ +L+LF+ ++LV + P + E ++ + FTL E
Sbjct: 695 LGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP-STQEWIVISYIFTLGIE 753
Query: 828 ELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGL 887
++R+ L G L Q+++++L + WN DL+A+ F +G+ RL
Sbjct: 754 KMREILMSEPGKLL------------QKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQP 801
Query: 888 YHL-GRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGV 946
+ GR + C++ + + +RLL IF VNK LGP ++++ KMM D+ +F+ + V L+++GV
Sbjct: 802 FRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGV 861
Query: 947 ATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGA 1006
A + +L P + + + +FY PY I+G++ + +D + N + E G P
Sbjct: 862 ARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQ--NETREDGKIIQLPPC 919
Query: 1007 QAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLI 1066
+ G W+V ++ +LLVANILLVNLLIA+F+ TF +V+ S+ WK QRY+LI
Sbjct: 920 KTGA-------WIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLI 972
Query: 1067 REFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEH-FRVYLSKEAERKLLTWE 1125
FH RP L PP I+ SH+ ++ + LC R R + ++ +++++ + +K+ +E
Sbjct: 973 MTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDELKKVHDFE 1032
Query: 1126 SVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLK----VLEREVQQ 1181
E + + S+ ER++ TS++V+ +L + E E +K ++ + Q
Sbjct: 1033 EQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVDIRLAQ 1092
Query: 1182 CSRVLGWVAEALSR 1195
++G +A AL R
Sbjct: 1093 LEDLIGRMATALER 1106
>gi|154091316 transient receptor potential cation channel, subfamily
M, member 3 isoform e [Homo sapiens]
Length = 1556
Score = 473 bits (1217), Expect = e-133
Identities = 349/1162 (30%), Positives = 587/1162 (50%), Gaps = 101/1162 (8%)
Query: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
Query: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGI 269
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK G
Sbjct: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-IGQ 175
Query: 270 DIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAGSGGAADCLAETLEDTLAPGSGGAR 327
+PV+ L+++G +++ + + +P ++ GSG A+D LA + + GG
Sbjct: 176 GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYS---EEGGLI 232
Query: 328 QGEARDRI-----RRF-FPKGDLEVLQAQVERIMTRKELLTVYS-SEDGSEEFETIVLKA 380
RD++ + F + + + L + M +KEL+TV+ +G ++ + +L A
Sbjct: 233 NESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTA 292
Query: 381 LVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEF 440
L+K +S D+L LA+AWNRVDIA+S++F QW LE +++DAL+ DR +F
Sbjct: 293 LLKGANASAP----DQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDF 348
Query: 441 VRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASHS-AGTKAPALKGGAAE 497
V+LLI +G+S+ FLT RL +LY+ PSN+L + D G KG
Sbjct: 349 VKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNL-- 406
Query: 498 LRPPD-------VGHVLRMLLGKMCAPRYPS-----------GGAWDPHPGQGFGESMYL 539
PPD +G V+ L+G Y G D P + ++
Sbjct: 407 --PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRDDIPLRRGRKTTKK 464
Query: 540 LSDKATSPLSLDAGLGQAPWS--DLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLR 597
++ L D + P+ +L++WA+L+ R +MA++FW+ G A++ AL AC L +
Sbjct: 465 REEEVDIDLD-DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCK 523
Query: 598 VMARLEPDAEEAARRKDLAFK-------FEGMGVDLFGECYRSSEVRAARLLLRRCPLWG 650
MA +A E D++ + F + V+L + Y+ E A +LL W
Sbjct: 524 AMAH---EASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWS 580
Query: 651 DATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWA-LVLAFFCPPLIYTRLIT 709
+ATCLQLA+ A R F A Q LLT W G + ++L PP I + +
Sbjct: 581 NATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILS--LE 638
Query: 710 FRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCL 769
F+ ++ P + + E P E+ + + GR R +
Sbjct: 639 FKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGESSRKKDEEEV 698
Query: 770 ----------RRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYF 819
R+ + F+ AP+ F ++Y+ +L+LF+ ++LV + P + E ++
Sbjct: 699 QSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP-STQEWIVIS 757
Query: 820 WAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGV 879
+ FTL E++R+ L G L Q+++++L + WN DL+A+ F +G+
Sbjct: 758 YIFTLGIEKMREILMSEPGKLL------------QKVKVWLQEYWNVTDLIAILLFSVGM 805
Query: 880 GCRLTPGLYHL-GRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLG 938
RL + GR + C++ + + +RLL IF VNK LGP ++++ KMM D+ +F+ +
Sbjct: 806 ILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIML 865
Query: 939 VWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPG 998
V L+++GVA + +L P + + + +FY PY I+G++ + +D + N + E G
Sbjct: 866 VVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCGQ--NETREDG 923
Query: 999 FWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYW 1058
P + G W+V ++ +LLVANILLVNLLIA+F+ TF +V+ S+ W
Sbjct: 924 KIIQLPPCKTGA-------WIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVW 976
Query: 1059 KAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEH-FRVYLSKEA 1117
K QRY+LI FH RP L PP I+ SH+ ++ + LC R R + ++ +++++ +
Sbjct: 977 KFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDYGLKLFITDDE 1036
Query: 1118 ERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLK---- 1173
+K+ +E E + + S+ ER++ TS++V+ +L + E E +K
Sbjct: 1037 LKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQ 1096
Query: 1174 VLEREVQQCSRVLGWVAEALSR 1195
++ + Q ++G +A AL R
Sbjct: 1097 TVDIRLAQLEDLIGRMATALER 1118
>gi|154091312 transient receptor potential cation channel, subfamily
M, member 3 isoform b [Homo sapiens]
Length = 1566
Score = 473 bits (1216), Expect = e-133
Identities = 350/1172 (29%), Positives = 590/1172 (50%), Gaps = 111/1172 (9%)
Query: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
Query: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGI 269
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK G
Sbjct: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTR-IGQ 175
Query: 270 DIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAGSGGAADCLAETLEDTLAPGSGGAR 327
+PV+ L+++G +++ + + +P ++ GSG A+D LA + + GG
Sbjct: 176 GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYS---EEGGLI 232
Query: 328 QGEARDRI-----RRF-FPKGDLEVLQAQVERIMTRKELLTVYS-SEDGSEEFETIVLKA 380
RD++ + F + + + L + M +KEL+TV+ +G ++ + +L A
Sbjct: 233 NESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTA 292
Query: 381 LVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEF 440
L+K +S D+L LA+AWNRVDIA+S++F QW LE +++DAL+ DR +F
Sbjct: 293 LLKGANASAP----DQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDF 348
Query: 441 VRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASHS-AGTKAPALKGGAAE 497
V+LLI +G+S+ FLT RL +LY+ PSN+L + D G KG
Sbjct: 349 VKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKREYPGFGWIYFKGNL-- 406
Query: 498 LRPPD-------VGHVLRMLLG-----------------KMCAPRYPSG----GAWDPHP 529
PPD +G V+ L+G + P+ P G D P
Sbjct: 407 --PPDYRISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIP 464
Query: 530 GQGFGESMYLLSDKATSPLSLDAGLGQAPWS--DLLLWALLLNRAQMAMYFWEMGSNAVS 587
+ ++ ++ L D + P+ +L++WA+L+ R +MA++FW+ G A++
Sbjct: 465 LRRGRKTTKKREEEVDIDLD-DPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMA 523
Query: 588 SALGACLLLRVMARLEPDAEEAARRKDLAFK-------FEGMGVDLFGECYRSSEVRAAR 640
AL AC L + MA +A E D++ + F + V+L + Y+ E A +
Sbjct: 524 KALVACKLCKAMAH---EASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMK 580
Query: 641 LLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWA-LVLAFFC 699
LL W +ATCLQLA+ A R F A Q LLT W G + ++L
Sbjct: 581 LLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILL 640
Query: 700 PPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCC 759
PP I + + F+ ++ P + + E P E+ + + GR
Sbjct: 641 PPSILS--LEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAMLGRNNGE 698
Query: 760 GGRCGGRRCL----------RRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAP 809
R + R+ + F+ AP+ F ++Y+ +L+LF+ ++LV + P
Sbjct: 699 SSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWP 758
Query: 810 PGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDL 869
+ E ++ + FTL E++R+ L G L Q+++++L + WN DL
Sbjct: 759 -STQEWIVISYIFTLGIEKMREILMSEPGKLL------------QKVKVWLQEYWNVTDL 805
Query: 870 VALTCFLLGVGCRLTPGLYHL-GRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMK 928
+A+ F +G+ RL + GR + C++ + + +RLL IF VNK LGP ++++ KMM
Sbjct: 806 IAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMI 865
Query: 929 DVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALM 988
D+ +F+ + V L+++GVA + +L P + + + +FY PY I+G++ + +D
Sbjct: 866 DMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDPPCG 925
Query: 989 EHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFG 1048
+ N + E G P + G W+V ++ +LLVANILLVNLLIA+F+ TF
Sbjct: 926 Q--NETREDGKIIQLPPCKTGA-------WIVPAIMACYLLVANILLVNLLIAVFNNTFF 976
Query: 1049 KVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEH 1108
+V+ S+ WK QRY+LI FH RP L PP I+ SH+ ++ + LC R R + ++
Sbjct: 977 EVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESDPDERDY 1036
Query: 1109 -FRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIRE 1167
+++++ + +K+ +E E + + S+ ER++ TS++V+ +L + E
Sbjct: 1037 GLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNE 1096
Query: 1168 YEQRLK----VLEREVQQCSRVLGWVAEALSR 1195
E +K ++ + Q ++G +A AL R
Sbjct: 1097 REHSMKASLQTVDIRLAQLEDLIGRMATALER 1128
>gi|154091308 transient receptor potential cation channel, subfamily
M, member 3 isoform f [Homo sapiens]
Length = 1579
Score = 467 bits (1202), Expect = e-131
Identities = 349/1182 (29%), Positives = 587/1182 (49%), Gaps = 118/1182 (9%)
Query: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
Query: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVG---- 265
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK
Sbjct: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPF 176
Query: 266 --------------------GTGIDIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAG 303
G G +PV+ L+++G +++ + + +P ++ G
Sbjct: 177 FSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDG 236
Query: 304 SGGAADCLAETLEDTLAPGSGGARQGEARDRI-----RRF-FPKGDLEVLQAQVERIMTR 357
SG A+D LA + + GG RD++ + F + + + L + M +
Sbjct: 237 SGRASDILAFGHKYS---EEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKK 293
Query: 358 KELLTVYS-SEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRG 416
KEL+TV+ +G ++ + +L AL+K +S D+L LA+AWNRVDIA+S++F
Sbjct: 294 KELITVFRMGSEGHQDIDLAILTALLKGANASAP----DQLSLALAWNRVDIARSQIFIY 349
Query: 417 DIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIR 474
QW LE +++DAL+ DR +FV+LLI +G+S+ FLT RL +LY+ PSN+L
Sbjct: 350 GQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYH 409
Query: 475 NLLDQASHSA-----------GTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSG- 522
+ D + G L GGA R R L + P+ P
Sbjct: 410 LVRDVKKGNLPPDYRISLIDIGLVIEYLMGGA--YRCNYTRKRFRTLYHNLFGPKRPKAL 467
Query: 523 ---GAWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPWS--DLLLWALLLNRAQMAMY 577
G D P + ++ ++ L D + P+ +L++WA+L+ R +MA++
Sbjct: 468 KLLGMEDDIPLRRGRKTTKKREEEVDIDLD-DPEINHFPFPFHELMVWAVLMKRQKMALF 526
Query: 578 FWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFK-------FEGMGVDLFGEC 630
FW+ G A++ AL AC L + MA +A E D++ + F + V+L +
Sbjct: 527 FWQHGEEAMAKALVACKLCKAMAH---EASENDMVDDISQELNHNSRDFGQLAVELLDQS 583
Query: 631 YRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPI 690
Y+ E A +LL W +ATCLQLA+ A R F A Q LLT W G +
Sbjct: 584 YKQDEQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNS 643
Query: 691 WA-LVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGV 749
++L PP I + + F+ ++ P + + E P E+ + +
Sbjct: 644 GLKVILGILLPPSILS--LEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMEL 701
Query: 750 PRQSGRPGCCGGRCGGRRCL----------RRWFHFWGAPVTIFMGNVVSYLLFLLLFSR 799
GR R + R+ + F+ AP+ F ++Y+ +L+LF+
Sbjct: 702 TAMLGRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNY 761
Query: 800 VLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLY 859
++LV + P + E ++ + FTL E++R+ L G L Q+++++
Sbjct: 762 IVLVKMERWP-STQEWIVISYIFTLGIEKMREILMSEPGKLL------------QKVKVW 808
Query: 860 LADSWNQCDLVALTCFLLGVGCRLTPGLYHL-GRTVLCIDFMVFTVRLLHIFTVNKQLGP 918
L + WN DL+A+ F +G+ RL + GR + C++ + + +RLL IF VNK LGP
Sbjct: 809 LQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGP 868
Query: 919 KIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQI 978
++++ KMM D+ +F+ + V L+++GVA + +L P + + + +FY PY I+G++
Sbjct: 869 YVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEV 928
Query: 979 PQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNL 1038
+ +D + N + E G P + G W+V ++ +LLVANILLVNL
Sbjct: 929 FADQIDPPCGQ--NETREDGKIIQLPPCKTGA-------WIVPAIMACYLLVANILLVNL 979
Query: 1039 LIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRS 1098
LIA+F+ TF +V+ S+ WK QRY+LI FH RP L PP I+ SH+ ++ + LC R R
Sbjct: 980 LIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRK 1039
Query: 1099 PQPSSPALEH-FRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDL 1157
+ ++ +++++ + +K+ +E E + + S+ ER++ TS++V+
Sbjct: 1040 HESDPDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVEN 1099
Query: 1158 ALKQLGHIREYEQRLK----VLEREVQQCSRVLGWVAEALSR 1195
+L + E E +K ++ + Q ++G +A AL R
Sbjct: 1100 MSMRLEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALER 1141
>gi|154091310 transient receptor potential cation channel, subfamily
M, member 3 isoform g [Homo sapiens]
Length = 1569
Score = 467 bits (1202), Expect = e-131
Identities = 347/1178 (29%), Positives = 587/1178 (49%), Gaps = 120/1178 (10%)
Query: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
Query: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVG---- 265
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK
Sbjct: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPF 176
Query: 266 --------------------GTGIDIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAG 303
G G +PV+ L+++G +++ + + +P ++ G
Sbjct: 177 FSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDG 236
Query: 304 SGGAADCLAETLEDTLAPGSGGARQGEARDRI-----RRF-FPKGDLEVLQAQVERIMTR 357
SG A+D LA + + GG RD++ + F + + + L + M +
Sbjct: 237 SGRASDILAFGHKYS---EEGGLINESLRDQLLVTIQKTFTYTRTQAQHLFIILMECMKK 293
Query: 358 KELLTVYS-SEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRG 416
KEL+TV+ +G ++ + +L AL+K +S D+L LA+AWNRVDIA+S++F
Sbjct: 294 KELITVFRMGSEGHQDIDLAILTALLKGANASAP----DQLSLALAWNRVDIARSQIFIY 349
Query: 417 DIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIR 474
QW LE +++DAL+ DR +FV+LLI +G+S+ FLT RL +LY+ PSN+L
Sbjct: 350 GQQWPVGSLEQAMLDALVLDRVDFVKLLIENGVSMHRFLTISRLEELYNTRHGPSNTLYH 409
Query: 475 NLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPS-----------GG 523
+ D G P + + D+G V+ L+G Y G
Sbjct: 410 LVRDVKK---GNLPPDYR-----ISLIDIGLVIEYLMGGAYRCNYTRKRFRTLYHNLFGP 461
Query: 524 AWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPWS--DLLLWALLLNRAQMAMYFWEM 581
D P + ++ ++ L D + P+ +L++WA+L+ R +MA++FW+
Sbjct: 462 KRDDIPLRRGRKTTKKREEEVDIDLD-DPEINHFPFPFHELMVWAVLMKRQKMALFFWQH 520
Query: 582 GSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFK-------FEGMGVDLFGECYRSS 634
G A++ AL AC L + MA +A E D++ + F + V+L + Y+
Sbjct: 521 GEEAMAKALVACKLCKAMAH---EASENDMVDDISQELNHNSRDFGQLAVELLDQSYKQD 577
Query: 635 EVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWA-L 693
E A +LL W +ATCLQLA+ A R F A Q LLT W G + +
Sbjct: 578 EQLAMKLLTYELKNWSNATCLQLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKV 637
Query: 694 VLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQS 753
+L PP I + + F+ ++ P + + E P E+ + +
Sbjct: 638 ILGILLPPSILS--LEFKNKDDMPYMSQAQEIHLQEKEAEEPEKPTKEKEEEDMELTAML 695
Query: 754 GRPGCCGGRCGGRRCL----------RRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLV 803
GR R + R+ + F+ AP+ F ++Y+ +L+LF+ ++LV
Sbjct: 696 GRNNGESSRKKDEEEVQSKHRLIPLGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLV 755
Query: 804 DFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADS 863
+ P + E ++ + FTL E++R+ L G L Q+++++L +
Sbjct: 756 KMERWP-STQEWIVISYIFTLGIEKMREILMSEPGKLL------------QKVKVWLQEY 802
Query: 864 WNQCDLVALTCFLLGVGCRLTPGLYHL-GRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVI 922
WN DL+A+ F +G+ RL + GR + C++ + + +RLL IF VNK LGP +++
Sbjct: 803 WNVTDLIAILLFSVGMILRLQDQPFRSDGRVIYCVNIIYWYIRLLDIFGVNKYLGPYVMM 862
Query: 923 VSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQED 982
+ KMM D+ +F+ + V L+++GVA + +L P + + + +FY PY I+G++ +
Sbjct: 863 IGKMMIDMMYFVIIMLVVLMSFGVARQAILFPNEEPSWKLAKNIFYMPYWMIYGEVFADQ 922
Query: 983 MDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAM 1042
+D + N + E G P + G W+V ++ +LLVANILLVNLLIA+
Sbjct: 923 IDPPCGQ--NETREDGKIIQLPPCKTGA-------WIVPAIMACYLLVANILLVNLLIAV 973
Query: 1043 FSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPS 1102
F+ TF +V+ S+ WK QRY+LI FH RP L PP I+ SH+ ++ + LC R R +
Sbjct: 974 FNNTFFEVKSISNQVWKFQRYQLIMTFHERPVLPPPLIIFSHMTMIFQHLCCRWRKHESD 1033
Query: 1103 SPALEH-FRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQ 1161
++ +++++ + +K+ +E E + + S+ ER++ TS++V+ +
Sbjct: 1034 PDERDYGLKLFITDDELKKVHDFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMR 1093
Query: 1162 LGHIREYEQRLK----VLEREVQQCSRVLGWVAEALSR 1195
L + E E +K ++ + Q ++G +A AL R
Sbjct: 1094 LEEVNEREHSMKASLQTVDIRLAQLEDLIGRMATALER 1131
>gi|18921093 transient receptor potential cation channel, subfamily M,
member 6 [Homo sapiens]
Length = 2022
Score = 465 bits (1197), Expect = e-130
Identities = 350/1244 (28%), Positives = 595/1244 (47%), Gaps = 143/1244 (11%)
Query: 5 EKEQSWIPKIFKKKTCTTFIVDSTDPGGTL-----------CQCGRPRTAHPAVAMEDAF 53
+ ++SWI +F K+ C+T I S +P C CGR H +
Sbjct: 11 QSQKSWIKGVFDKRECSTIIPSSKNPHRCTPVCQVCQNLIRCYCGRLIGDHAGIDYSWTI 70
Query: 54 GAAV---VTVWDSDAHTTEKPTDAYGELDFT-GAGRKHSNFLRLSDRTDPAAVYSLVTRT 109
AA W + HTT+ PTD +G ++F G H+ ++R S T + L+ +
Sbjct: 71 SAAKGKESEQWSVEKHTTKSPTDTFGTINFQDGEHTHHAKYIRTSYDTKLDHLLHLMLKE 130
Query: 110 WGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVA 169
W P LV+SV GG + + +++ +GLV+AA++TGAWI+T G++TG+ +HVG A
Sbjct: 131 WKMELPKLVISVHGGIQNFTMPSKFKEIFSQGLVKAAETTGAWIITEGINTGVSKHVGDA 190
Query: 170 VRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNY 229
++ H S K+ +G+ PWGV+ N+ LI Y+ +P + L+ +
Sbjct: 191 LKSHSSHSL--RKIWTVGIPPWGVIENQRDLIGK--DVVCLYQTLDNPLSKLT-TLNSMH 245
Query: 230 SAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIE 289
S F L DDGT G G E + R LE Y+S QK +PV+ L+++G ++ +
Sbjct: 246 SHFILSDDGTVGKYGNEMKLRRNLEKYLSLQKIHCRSRQ-GVPVVGLVVEGGPNVILSVW 304
Query: 290 NATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIR-----------RF 338
+ + P ++ G+G AAD LA T + A +G R +++ F
Sbjct: 305 ETVKDKDPVVVCEGTGRAADLLAFTHKHL-------ADEGMLRPQVKEEIICMIQNTFNF 357
Query: 339 FPKGDLEVLQAQVERIMTRKELLTVYSSE-DGSEEFETIVLKALVKACGSSEASAYLDEL 397
K + Q +E M ++ +T++ ++ + ++ + +L AL+K S + ++L
Sbjct: 358 SLKQSKHLFQILME-CMVHRDCITIFDADSEEQQDLDLAILTALLKGTNLSAS----EQL 412
Query: 398 RLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTP 457
LA+AW+RVDIA+ + + W+ LE ++ DAL+ DR +FV+LLI +G++L FLT
Sbjct: 413 NLAMAWDRVDIAKKHILIYEQHWKPDALEQAMSDALVMDRVDFVKLLIEYGVNLHRFLTI 472
Query: 458 MRLAQLYSA--APSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMC 515
RL +LY+ P+N+L+ +L+ K L G + D+G V+ L+G+
Sbjct: 473 PRLEELYNTKQGPTNTLLHHLVQD------VKQHTLLSG-YRITLIDIGLVVEYLIGRAY 525
Query: 516 APRYPSGG------------AWDPHPGQGFGESM--------------YLLSDKA----- 544
Y H ES Y +K+
Sbjct: 526 RSNYTRKHFRALYNNLYRKYKHQRHSSGNRNESAESTLHSQFIRTAQPYKFKEKSIVLHK 585
Query: 545 TSPLSLDAGLGQAPWS--------DLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLL 596
+ S + + P S DLL+WA+L+ R +MAM+FW+ G A A+ AC+L
Sbjct: 586 SRKKSKEQNVSDDPESTGFLYPYNDLLVWAVLMKRQKMAMFFWQHGEEATVKAVIACILY 645
Query: 597 RVMARLEPDA----EEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDA 652
R MA ++ + + K+ + +F + +DL + ++ +E A LL W ++
Sbjct: 646 RAMAHEAKESHMVDDASEELKNYSKQFGQLALDLLEKAFKQNERMAMTLLTYELRNWSNS 705
Query: 653 TCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIW-ALVLAFFCPPLIYTRLITFR 711
TCL+LA+ R F + Q LLT W G + W ++++ PP I T + F+
Sbjct: 706 TCLKLAVSGGLRPFVSHTCTQMLLTDMWMGRLKMRKNSWLKIIISIILPPTILT--LEFK 763
Query: 712 -KSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPR---QSGRPGCCGGRCGGRR 767
K+E + +F + + + + A + R + G G +
Sbjct: 764 SKAEMSHVPQSQDFQFMWYYSDQNASSSKESASVKEYDLERGHDEKLDENQHFGLESGHQ 823
Query: 768 CL---RRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTL 824
L R+ + F+ AP+ F ++YL FL+LF+ +LV+ QP P E L+ + FT
Sbjct: 824 HLPWTRKVYEFYSAPIVKFWFYTMAYLAFLMLFTYTVLVEMQP-QPSVQEWLVSIYIFTN 882
Query: 825 LCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL- 883
E +R+ + PG +Q++++++++ WN + VA+ F G R
Sbjct: 883 AIEVVRE--------ICISEPG----KFTQKVKVWISEYWNLTETVAIGLFSAGFVLRWG 930
Query: 884 TPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVA 943
P + GR + CID + + RLL F VN+ GP + +++KM ++F+ + + + L++
Sbjct: 931 DPPFHTAGRLIYCIDIIFWFSRLLDFFAVNQHAGPYVTMIAKMTANMFYIVIIMAIVLLS 990
Query: 944 YGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHP 1003
+GVA + +L P++ S+ R + + PY I+G++ ++DV CSS+P + P
Sbjct: 991 FGVARKAILSPKEPPSWSLARDIVFEPYWMIYGEVYAGEIDV-------CSSQP---SCP 1040
Query: 1004 PGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRY 1063
PG ++L L ++L V I++VNLLIA F+ + ++ S+ WK RY
Sbjct: 1041 PG-----------SFLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLDMESISNNLWKYNRY 1089
Query: 1064 RLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLT 1123
R I +H +P L PP I++SH+ LLLR+LC R+P ++YLSKE +KL
Sbjct: 1090 RYIMTYHEKPWLPPPLILLSHVGLLLRRLCCH-RAPHDQEEGDVGLKLYLSKEDLKKLHD 1148
Query: 1124 WESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIRE 1167
+E E + + D S ER++ TS++V QL + E
Sbjct: 1149 FEEQCVEKYFHEKMEDVNCSCEERIRVTSERVTEMYFQLKEMNE 1192
>gi|94538366 transient receptor potential cation channel, subfamily M,
member 1 [Homo sapiens]
Length = 1603
Score = 313 bits (802), Expect = 6e-85
Identities = 234/790 (29%), Positives = 387/790 (48%), Gaps = 84/790 (10%)
Query: 425 LEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSA--APSNSLIRNLLDQASH 482
LE +++DAL+ DR +FV+LLI +G+++ HFLT RL +LY+ P N+L + D
Sbjct: 461 LEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKS 520
Query: 483 SA-----------GTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPS-----GGAWD 526
+ G L GGA R R L + P+ P G D
Sbjct: 521 NLPPDYHISLIDIGLVLEYLMGGA--YRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDD 578
Query: 527 PHPGQGFGESMYLLSDKATSPLSLDA-----GLGQAPWSDLLLWALLLNRAQMAMYFWEM 581
P +G + K + +D Q P+ +L++WA+L+ R +MA++ W+
Sbjct: 579 EPPAKGKKKK----KKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQR 634
Query: 582 GSNAVSSALGACLLLRVMARLEPDAE---EAARRKDLAFK-FEGMGVDLFGECYRSSEVR 637
G +++ AL AC L + MA +++ + ++ D K F + ++L + Y+ E
Sbjct: 635 GEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQI 694
Query: 638 AARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMAST-TPIWALVLA 696
A +LL W ++TCL+LA+ A R F A Q LLT W G + P +++
Sbjct: 695 AMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMG 754
Query: 697 FFCPPLIYTRLITFR---------KSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPL 747
PP I + FR E E +E+ E + D+ + G + K
Sbjct: 755 ILLPPTIL--FLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQR 812
Query: 748 GVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQP 807
+P G + C F+ AP+ F +SYL +LLLF+ V+LV
Sbjct: 813 SIP------------IGTKIC-----EFYNAPIVKFWFYTISYLGYLLLFNYVILVRMD- 854
Query: 808 APPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQC 867
P E ++ + +L E++R+ L G L SQ+++++L + WN
Sbjct: 855 GWPSLQEWIVISYIVSLALEKIREILMSEPGKL------------SQKIKVWLQEYWNIT 902
Query: 868 DLVALTCFLLGVGCRLTPGLYH-LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKM 926
DLVA++ F++G RL Y GR + C+D + + +R+L IF VNK LGP ++++ KM
Sbjct: 903 DLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKM 962
Query: 927 MKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVA 986
M D+ +F+ + V L+++GVA + +L P + + R +FY PY I+G++ + +D+
Sbjct: 963 MIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLY 1022
Query: 987 LMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYT 1046
ME + E + G + C+ WL L+ +LLVANILLVNLLIA+F+ T
Sbjct: 1023 AMEINPPCGENLY--DEEGKRLPPCIP--GAWLTPALMACYLLVANILLVNLLIAVFNNT 1078
Query: 1047 FGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQL---CRRPRSPQPSS 1103
F +V+ S+ WK QRY+LI FH RP L PP I++SH+ +++ +L CR+ R
Sbjct: 1079 FFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEE 1138
Query: 1104 PALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLG 1163
+++LS E ++L +E + + +++ S ER++ TS++V+ +L
Sbjct: 1139 RD-RGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLE 1197
Query: 1164 HIREYEQRLK 1173
I E E +K
Sbjct: 1198 EINERETFMK 1207
Score = 186 bits (471), Expect = 2e-46
Identities = 123/370 (33%), Positives = 200/370 (54%), Gaps = 23/370 (6%)
Query: 61 WDSDAHTTEKPTDAYGELDFTGAGRKH-SNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVV 119
W HT PTD+YG L+F G G + + ++R+S T P ++ L+ + W P L++
Sbjct: 42 WSVAKHTQSYPTDSYGVLEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLI 101
Query: 120 SVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTG 179
SV GG +Q L+ + +GL++AA +TGAWI TGG+ TG+ HVG A++DH S G
Sbjct: 102 SVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRG 161
Query: 180 GTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGT 239
+V A+G+APWG+V N++ L+ Y+ +P + L+ +++ F L D+GT
Sbjct: 162 --RVCAIGIAPWGIVENKEDLVGK--DVTRVYQTMSNPLSKLSV-LNNSHTHFILADNGT 216
Query: 240 HGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQ--LP 297
G G E + R LE +IS QK G +P++ L+++G +++ + Q + +P
Sbjct: 217 LGKYGAEVKLRRLLEKHISLQKINT-RLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIP 275
Query: 298 CLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRI-----RRF-FPKGDLEVLQAQV 351
++ GSG A+D L+ + GG R+++ + F + K L A +
Sbjct: 276 VVICDGSGRASDILSFAHKYC---EEGGIINESLREQLLVTIQKTFNYNKAQSHQLFAII 332
Query: 352 ERIMTRKELLTVY-SSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQ 410
M +KEL+TV+ +G ++ E +L AL+K S D+L LA+AWNRVDIA+
Sbjct: 333 MECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVSAP----DQLSLALAWNRVDIAR 388
Query: 411 SELFRGDIQW 420
S++F W
Sbjct: 389 SQIFVFGPHW 398
>gi|148612863 transient receptor potential cation channel, subfamily
M, member 7 [Homo sapiens]
Length = 1865
Score = 255 bits (651), Expect = 2e-67
Identities = 183/537 (34%), Positives = 280/537 (52%), Gaps = 49/537 (9%)
Query: 7 EQSWIPKIFKKKTCTTFIVDSTDP-----GGTLCQ------CGRPRTAHPA--------- 46
++SWI K+ C I S DP G +CQ CGR H
Sbjct: 3 QKSWIESTLTKRECVYIIPSSKDPHRCLPGCQICQQLVRCFCGRLVKQHACFTASLAMKY 62
Query: 47 --VAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKH-SNFLRLSDRTDPAAVY 103
V + D F A+ W + HT + PTDAYG ++F G + + ++RLS T P +
Sbjct: 63 SDVKLGDHFNQAIEE-WSVEKHTEQSPTDAYGVINFQGGSHSYRAKYVRLSYDTKPEVIL 121
Query: 104 SLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIG 163
L+ + W P LV+SV GG L ++ LL +GL++AA +TGAWI+TGG++TG+
Sbjct: 122 QLLLKEWQMELPKLVISVHGGMQKFELHPRIKQLLGKGLIKAAVTTGAWILTGGVNTGVA 181
Query: 164 RHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQF 223
+HVG A+++H AS K+ +G+APWGV+ NR+ L+ A Y+ +P +
Sbjct: 182 KHVGDALKEH--ASRSSRKICTIGIAPWGVIENRNDLVG--RDVVAPYQTLLNPLSKLNV 237
Query: 224 PLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEK 283
L+ +S F LVDDGT G G E R R LE I+QQ+ G +PV+ L+ +G
Sbjct: 238 -LNNLHSHFILVDDGTVGKYGAEVRLRRELEKTINQQRIH-ARIGQGVPVVALIFEGGPN 295
Query: 284 MLTRIENATQAQ--LPCLLVAGSGGAADCLAETLEDTLAPGS-GGARQGEARDRIRRFFP 340
++ + Q +P ++ G+G AAD LA + T G+ A + + I++ F
Sbjct: 296 VILTVLEYLQESPPVPVVVCEGTGRAADLLAYIHKQTEEGGNLPDAAEPDIISTIKKTFN 355
Query: 341 KGDLEVLQ--AQVERIMTRKELLTVYS-SEDGSEEFETIVLKALVKACGSSEASAYLDEL 397
G E L + M RKEL+TV+ D ++ + +L AL+K + ASA+ D+L
Sbjct: 356 FGQNEALHLFQTLMECMKRKELITVFHIGSDEHQDIDVAILTALLK---GTNASAF-DQL 411
Query: 398 RLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTP 457
L +AW+RVDIA++ +F QW LE +++DAL+ DR FV+LLI +G+S+ FLT
Sbjct: 412 ILTLAWDRVDIAKNHVFVYGQQWLVGSLEQAMLDALVMDRVAFVKLLIENGVSMHKFLTI 471
Query: 458 MRLAQLYSA--APSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLG 512
RL +LY+ P+N ++ +L+ G P K + D+G V+ L+G
Sbjct: 472 PRLEELYNTKQGPTNPMLFHLVRDVKQ--GNLPPGYK-----ITLIDIGLVIEYLMG 521
Score = 239 bits (611), Expect = 9e-63
Identities = 166/653 (25%), Positives = 313/653 (47%), Gaps = 63/653 (9%)
Query: 558 PWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAE----EAARRK 613
P ++LL+WA L+ R MA + W+ G +++ AL AC + R MA ++ + K
Sbjct: 621 PLNELLIWACLMKRQVMARFLWQHGEESMAKALVACKIYRSMAYEAKQSDLVDDTSEELK 680
Query: 614 DLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQ 673
+ F + V+L + +R E A +LL W ++TCL+LA+ + R F A Q
Sbjct: 681 QYSNDFGQLAVELLEQSFRQDETMAMKLLTYELKNWSNSTCLKLAVSSRLRPFVAHTCTQ 740
Query: 674 SLLTQKWWGDMASTTPIW-ALVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVING 732
LL+ W G + W ++L+ PP I L+ K++ E + D +
Sbjct: 741 MLLSDMWMGRLNMRKNSWYKVILSILVPPAI---LLLEYKTKAEMSHIPQSQDAHQMTMD 797
Query: 733 EGPVGTADPAEKTPLGVPRQSGRPGCCGG--------RCGGRRCLRRWFHFWGAPVTIFM 784
+ + E+ P+ V ++ G + R+++ F+ AP+ F
Sbjct: 798 DSENNFQNITEEIPMEVFKEVRILDSNEGKNEMEIQMKSKKLPITRKFYAFYHAPIVKFW 857
Query: 785 GNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGG 844
N ++YL FL+L++ V+LV + P E ++ + FT E++R+ G
Sbjct: 858 FNTLAYLGFLMLYTFVVLVQMEQL-PSVQEWIVIAYIFTYAIEKVREIFMSEAG------ 910
Query: 845 PGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRL----------TPGLYHLGRTV 894
++Q+++++ +D +N D +A+ F +G G R ++ GR +
Sbjct: 911 ------KVNQKIKVWFSDYFNISDTIAIISFFIGFGLRFGAKWNFANAYDNHVFVAGRLI 964
Query: 895 LCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRP 954
C++ + + VRLL VN+Q GP ++++ KM+ ++F+ + + + L+++GV + +L P
Sbjct: 965 YCLNIIFWYVRLLDFLAVNQQAGPYVMMIGKMVANMFYIVVIMALVLLSFGVPRKAILYP 1024
Query: 955 RDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQ 1014
++ ++ + + + PY IFG++ ++DV +N S P PG
Sbjct: 1025 HEAPSWTLAKDIVFHPYWMIFGEVYAYEIDVC----ANDSVIPQICG--PG--------- 1069
Query: 1015 YANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPA 1074
WL L ++L V I++VNLLIA F+ + +V+ S++ WK QRY I +H +P
Sbjct: 1070 --TWLTPFLQAVYLFVQYIIMVNLLIAFFNNVYLQVKAISNIVWKYQRYHFIMAYHEKPV 1127
Query: 1075 LAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLL 1134
L PP I++SH+ L +C+R + + S +++L++E ++KL +E E +
Sbjct: 1128 LPPPLIILSHIVSLFCCICKRRKKDKTSDGP----KLFLTEEDQKKLHDFEEQCVEMYFN 1183
Query: 1135 ARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLG 1187
+ ER++ T ++V+ Q I+E R+ ++R +Q +G
Sbjct: 1184 EKDDKFHSGSEERIRVTFERVEQMCIQ---IKEVGDRVNYIKRSLQSLDSQIG 1233
>gi|45935368 transient receptor potential cation channel, subfamily
M, member 3 isoform h [Homo sapiens]
Length = 230
Score = 136 bits (342), Expect = 1e-31
Identities = 82/225 (36%), Positives = 130/225 (57%), Gaps = 8/225 (3%)
Query: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
Query: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGI 269
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK G
Sbjct: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINT-RIGQ 175
Query: 270 DIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAGSGGAADCLA 312
+PV+ L+++G +++ + + +P ++ GSG A+D LA
Sbjct: 176 GVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILA 220
>gi|55953096 transient receptor potential cation channel, subfamily
M, member 3 isoform c [Homo sapiens]
Length = 255
Score = 129 bits (325), Expect = 1e-29
Identities = 83/249 (33%), Positives = 131/249 (52%), Gaps = 31/249 (12%)
Query: 90 FLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQST 149
++R+S T P + L+T+ W P L++SV GG LQ L+ + +GL++AA +T
Sbjct: 2 YVRVSFDTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTT 61
Query: 150 GAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPA 209
GAWI TGG++TG+ RHVG A++DH S G K+ +G+APWG+V N++ LI P
Sbjct: 62 GAWIFTGGVNTGVIRHVGDALKDHASKSRG--KICTIGIAPWGIVENQEDLIGRDVVRP- 118
Query: 210 RYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVG---- 265
Y+ +P + L+ +S F L D+GT G G E + R +LE +IS QK
Sbjct: 119 -YQTMSNPMSKLTV-LNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRCLPF 176
Query: 266 --------------------GTGIDIPVLLLLIDGDEKMLTRIENATQ--AQLPCLLVAG 303
G G +PV+ L+++G +++ + + +P ++ G
Sbjct: 177 FSLDSRLFYSFWGSCQLDSVGIGQGVPVVALIVEGGPNVISIVLEYLRDTPPVPVVVCDG 236
Query: 304 SGGAADCLA 312
SG A+D LA
Sbjct: 237 SGRASDILA 245
>gi|209863032 transient receptor potential cation channel, subfamily
C, member 4 isoform zeta [Homo sapiens]
Length = 804
Score = 64.7 bits (156), Expect = 5e-10
Identities = 77/370 (20%), Positives = 147/370 (39%), Gaps = 88/370 (23%)
Query: 779 PVTIFMGNVVSYL--LFLLLFSRVLL----VDFQPAPPGSLELLLYFWAFTLLCEELRQG 832
P F+ + SYL LFLLL + + ++ Q PP +E ++ W + E++Q
Sbjct: 189 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 248
Query: 833 LSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTP------- 885
GG L+ Y+ D WN D V + +L + ++
Sbjct: 249 WDGG-------------------LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL 289
Query: 886 ------GLYH---LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFF 936
++H + + I + ++RL+ +FT N LGP + + +M+ D+ FLF
Sbjct: 290 NPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI 349
Query: 937 LGVWLVAY---------------GVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQE 981
+ L+A+ G+ +G+ + ++ S L + IFG I
Sbjct: 350 YCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN-- 407
Query: 982 DMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIA 1041
+ +N ++ F GT + +++ ++L+N+LIA
Sbjct: 408 ------LYVTNVKAQHEFTEFVGATMFGT----------------YNVISLVVLLNMLIA 445
Query: 1042 MFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPFIVISH-------LRLLLRQLC 1093
M + ++ + ++D+ WK R +L + F L PF VI ++ + LC
Sbjct: 446 MMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 505
Query: 1094 RRPRSPQPSS 1103
++ +P S
Sbjct: 506 KKKMRRKPES 515
>gi|209863030 transient receptor potential cation channel, subfamily
C, member 4 isoform delta [Homo sapiens]
Length = 836
Score = 64.7 bits (156), Expect = 5e-10
Identities = 77/370 (20%), Positives = 147/370 (39%), Gaps = 88/370 (23%)
Query: 779 PVTIFMGNVVSYL--LFLLLFSRVLL----VDFQPAPPGSLELLLYFWAFTLLCEELRQG 832
P F+ + SYL LFLLL + + ++ Q PP +E ++ W + E++Q
Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421
Query: 833 LSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTP------- 885
GG L+ Y+ D WN D V + +L + ++
Sbjct: 422 WDGG-------------------LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL 462
Query: 886 ------GLYH---LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFF 936
++H + + I + ++RL+ +FT N LGP + + +M+ D+ FLF
Sbjct: 463 NPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI 522
Query: 937 LGVWLVAY---------------GVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQE 981
+ L+A+ G+ +G+ + ++ S L + IFG I
Sbjct: 523 YCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN-- 580
Query: 982 DMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIA 1041
+ +N ++ F GT + +++ ++L+N+LIA
Sbjct: 581 ------LYVTNVKAQHEFTEFVGATMFGT----------------YNVISLVVLLNMLIA 618
Query: 1042 MFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPFIVISH-------LRLLLRQLC 1093
M + ++ + ++D+ WK R +L + F L PF VI ++ + LC
Sbjct: 619 MMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
Query: 1094 RRPRSPQPSS 1103
++ +P S
Sbjct: 679 KKKMRRKPES 688
>gi|209863026 transient receptor potential cation channel, subfamily
C, member 4 isoform beta [Homo sapiens]
Length = 893
Score = 64.7 bits (156), Expect = 5e-10
Identities = 77/370 (20%), Positives = 147/370 (39%), Gaps = 88/370 (23%)
Query: 779 PVTIFMGNVVSYL--LFLLLFSRVLL----VDFQPAPPGSLELLLYFWAFTLLCEELRQG 832
P F+ + SYL LFLLL + + ++ Q PP +E ++ W + E++Q
Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421
Query: 833 LSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTP------- 885
GG L+ Y+ D WN D V + +L + ++
Sbjct: 422 WDGG-------------------LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL 462
Query: 886 ------GLYH---LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFF 936
++H + + I + ++RL+ +FT N LGP + + +M+ D+ FLF
Sbjct: 463 NPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI 522
Query: 937 LGVWLVAY---------------GVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQE 981
+ L+A+ G+ +G+ + ++ S L + IFG I
Sbjct: 523 YCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN-- 580
Query: 982 DMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIA 1041
+ +N ++ F GT + +++ ++L+N+LIA
Sbjct: 581 ------LYVTNVKAQHEFTEFVGATMFGT----------------YNVISLVVLLNMLIA 618
Query: 1042 MFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPFIVISH-------LRLLLRQLC 1093
M + ++ + ++D+ WK R +L + F L PF VI ++ + LC
Sbjct: 619 MMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
Query: 1094 RRPRSPQPSS 1103
++ +P S
Sbjct: 679 KKKMRRKPES 688
>gi|209863024 transient receptor potential cation channel, subfamily
C, member 4 isoform epsilon [Homo sapiens]
Length = 982
Score = 64.7 bits (156), Expect = 5e-10
Identities = 77/370 (20%), Positives = 147/370 (39%), Gaps = 88/370 (23%)
Query: 779 PVTIFMGNVVSYL--LFLLLFSRVLL----VDFQPAPPGSLELLLYFWAFTLLCEELRQG 832
P F+ + SYL LFLLL + + ++ Q PP +E ++ W + E++Q
Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421
Query: 833 LSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTP------- 885
GG L+ Y+ D WN D V + +L + ++
Sbjct: 422 WDGG-------------------LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL 462
Query: 886 ------GLYH---LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFF 936
++H + + I + ++RL+ +FT N LGP + + +M+ D+ FLF
Sbjct: 463 NPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI 522
Query: 937 LGVWLVAY---------------GVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQE 981
+ L+A+ G+ +G+ + ++ S L + IFG I
Sbjct: 523 YCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN-- 580
Query: 982 DMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIA 1041
+ +N ++ F GT + +++ ++L+N+LIA
Sbjct: 581 ------LYVTNVKAQHEFTEFVGATMFGT----------------YNVISLVVLLNMLIA 618
Query: 1042 MFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPFIVISH-------LRLLLRQLC 1093
M + ++ + ++D+ WK R +L + F L PF VI ++ + LC
Sbjct: 619 MMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
Query: 1094 RRPRSPQPSS 1103
++ +P S
Sbjct: 679 KKKMRRKPES 688
>gi|7706747 transient receptor potential cation channel, subfamily C,
member 4 isoform alpha [Homo sapiens]
Length = 977
Score = 64.7 bits (156), Expect = 5e-10
Identities = 77/370 (20%), Positives = 147/370 (39%), Gaps = 88/370 (23%)
Query: 779 PVTIFMGNVVSYL--LFLLLFSRVLL----VDFQPAPPGSLELLLYFWAFTLLCEELRQG 832
P F+ + SYL LFLLL + + ++ Q PP +E ++ W + E++Q
Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421
Query: 833 LSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTP------- 885
GG L+ Y+ D WN D V + +L + ++
Sbjct: 422 WDGG-------------------LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL 462
Query: 886 ------GLYH---LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFF 936
++H + + I + ++RL+ +FT N LGP + + +M+ D+ FLF
Sbjct: 463 NPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI 522
Query: 937 LGVWLVAY---------------GVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQE 981
+ L+A+ G+ +G+ + ++ S L + IFG I
Sbjct: 523 YCLVLLAFANGLNQLYFYYEETKGLTCKGIRCEKQNNAFSTLFETLQSLFWSIFGLIN-- 580
Query: 982 DMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIA 1041
+ +N ++ F GT + +++ ++L+N+LIA
Sbjct: 581 ------LYVTNVKAQHEFTEFVGATMFGT----------------YNVISLVVLLNMLIA 618
Query: 1042 MFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPFIVISH-------LRLLLRQLC 1093
M + ++ + ++D+ WK R +L + F L PF VI ++ + LC
Sbjct: 619 MMNNSYQLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLIKWIWTHLC 678
Query: 1094 RRPRSPQPSS 1103
++ +P S
Sbjct: 679 KKKMRRKPES 688
>gi|6912736 transient receptor potential cation channel, subfamily C,
member 5 [Homo sapiens]
Length = 973
Score = 57.4 bits (137), Expect = 8e-08
Identities = 64/337 (18%), Positives = 132/337 (39%), Gaps = 68/337 (20%)
Query: 779 PVTIFMGNVVSYLLFLLLF----SRVLLVDF--QPAPPGSLELLLYFWAFTLLCEELRQG 832
P F+ + SYL FL + ++ D Q PP +E ++ W + E+++
Sbjct: 363 PFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEM 422
Query: 833 LSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLG- 891
GG Y+ D WN D + +L + ++ + + G
Sbjct: 423 WDGG-------------------FTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGS 463
Query: 892 ---------------RTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFF 936
+ I ++ ++RL+ +FT N LGP + + +M+ D+ FLF
Sbjct: 464 RPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI 523
Query: 937 LGVWLVAYGVATEGL---LRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNC 993
+ L+A+ L R D P+ + + F + +
Sbjct: 524 YCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFE------------- 570
Query: 994 SSEPGFWA-------HPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYT 1046
+ + FW+ + +A ++ ++ + + +++ ++L+N+LIAM + +
Sbjct: 571 TLQSLFWSVFGLLNLYVTNVKAR---HEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNS 627
Query: 1047 FGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPFIVI 1082
+ + ++D+ WK R +L + F L PPF +I
Sbjct: 628 YQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNII 664
>gi|209863028 transient receptor potential cation channel, subfamily
C, member 4 isoform gamma [Homo sapiens]
Length = 828
Score = 49.7 bits (117), Expect = 2e-05
Identities = 44/188 (23%), Positives = 80/188 (42%), Gaps = 41/188 (21%)
Query: 779 PVTIFMGNVVSYL--LFLLLFSRVLL----VDFQPAPPGSLELLLYFWAFTLLCEELRQG 832
P F+ + SYL LFLLL + + ++ Q PP +E ++ W + E++Q
Sbjct: 362 PFIKFICHTASYLTFLFLLLLASQHIDRSDLNRQGPPPTIVEWMILPWVLGFIWGEIKQM 421
Query: 833 LSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTP------- 885
GG L+ Y+ D WN D V + +L + ++
Sbjct: 422 WDGG-------------------LQDYIHDWWNLMDFVMNSLYLATISLKIVAFVKYSAL 462
Query: 886 ------GLYH---LGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFF 936
++H + + I + ++RL+ +FT N LGP + + +M+ D+ FLF
Sbjct: 463 NPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFI 522
Query: 937 LGVWLVAY 944
+ L+A+
Sbjct: 523 YCLVLLAF 530
>gi|194733735 transient receptor potential cation channel, subfamily
C, member 3 isoform a [Homo sapiens]
Length = 921
Score = 44.7 bits (104), Expect = 5e-04
Identities = 59/300 (19%), Positives = 118/300 (39%), Gaps = 58/300 (19%)
Query: 905 RLLHIFTVNKQLGPKIVIVSKMMKDVF---------FFLFFLGVWLVA---YGVATEGLL 952
R+ +I N+ GP + + + +KD+F FF F +G++++ G
Sbjct: 625 RIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAF 684
Query: 953 RPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCV 1012
+ F ++ + IFG E V L G+
Sbjct: 685 TTVEESFKTL--------FWSIFGL--SEVTSVVLKYDHKFIENIGY------------- 721
Query: 1013 SQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRL-IREFHS 1071
+L I+ + ++L+N+LIAM + ++ +++ +SD+ WK R +L + F
Sbjct: 722 ---------VLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDD 772
Query: 1072 RPALAPPFIVISH--------LRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLT 1123
L PPF ++ +R++ CRR R + + + + L+ +
Sbjct: 773 GKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRV 832
Query: 1124 WESVHKENFLLARARDKRESDSERLKRTSQKVDLALK----QLGHIREYEQRLKVLEREV 1179
+ES H N +L + ++ +KR K + + G ++E +Q + L E+
Sbjct: 833 FES-HSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYEL 891
>gi|4507687 transient receptor potential cation channel, subfamily C,
member 3 isoform b [Homo sapiens]
Length = 848
Score = 44.7 bits (104), Expect = 5e-04
Identities = 59/300 (19%), Positives = 118/300 (39%), Gaps = 58/300 (19%)
Query: 905 RLLHIFTVNKQLGPKIVIVSKMMKDVF---------FFLFFLGVWLVA---YGVATEGLL 952
R+ +I N+ GP + + + +KD+F FF F +G++++ G
Sbjct: 552 RIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFFAFMIGMFILYSYYLGAKVNAAF 611
Query: 953 RPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCV 1012
+ F ++ + IFG E V L G+
Sbjct: 612 TTVEESFKTL--------FWSIFGL--SEVTSVVLKYDHKFIENIGY------------- 648
Query: 1013 SQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRL-IREFHS 1071
+L I+ + ++L+N+LIAM + ++ +++ +SD+ WK R +L + F
Sbjct: 649 ---------VLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDD 699
Query: 1072 RPALAPPFIVISH--------LRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLT 1123
L PPF ++ +R++ CRR R + + + + L+ +
Sbjct: 700 GKTLPPPFSLVPSPKSFVYFIMRIVNFPKCRRRRLQKDIEMGMGNSKSRLNLFTQSNSRV 759
Query: 1124 WESVHKENFLLARARDKRESDSERLKRTSQKVDLALK----QLGHIREYEQRLKVLEREV 1179
+ES H N +L + ++ +KR K + + G ++E +Q + L E+
Sbjct: 760 FES-HSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYEL 818
>gi|4507685 transient receptor potential cation channel, subfamily C,
member 1 [Homo sapiens]
Length = 759
Score = 43.5 bits (101), Expect = 0.001
Identities = 46/186 (24%), Positives = 87/186 (46%), Gaps = 18/186 (9%)
Query: 904 VRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSIL 963
+RL ++T + LGP + + +M++D F FLG++L+ T GL + D + S
Sbjct: 477 LRLFFMYTTSSILGPLQISMGQMLQD---FGKFLGMFLLVLFSFTIGLTQLYDKGYTSKE 533
Query: 964 RRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYA------N 1017
++ + IF + Q+ D C + FW A V++++ +
Sbjct: 534 QK----DCVGIFCE--QQSNDTFHSFIGTCFAL--FWYIFSLAHVAIFVTRFSYGEELQS 585
Query: 1018 WLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALA 1076
++ +++ + +V I+L LL+AM +F + + D WK R +L + F + L
Sbjct: 586 FVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLP 645
Query: 1077 PPFIVI 1082
PPF +I
Sbjct: 646 PPFNII 651
>gi|21735483 transient receptor potential cation channel, subfamily V,
member 3 [Homo sapiens]
Length = 790
Score = 42.0 bits (97), Expect = 0.004
Identities = 39/152 (25%), Positives = 69/152 (45%), Gaps = 27/152 (17%)
Query: 920 IVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLR--PRDSDFPSILRRVFYRPYLQIFGQ 977
++I ++ DV FLF V+L+ +GVA L+ P+D+ S F L++F +
Sbjct: 577 VMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGS-FSDAVLELF-K 634
Query: 978 IPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVN 1037
+ D+ + ++S L + LL+ ++++ +LL+N
Sbjct: 635 LTIGLGDLNIQQNSKYPI-----------------------LFLFLLITYVILTFVLLLN 671
Query: 1038 LLIAMFSYTFGKVQGNSDLYWKAQRYRLIREF 1069
+LIA+ T V S+ W+ QR R I EF
Sbjct: 672 MLIALMGETVENVSKESERIWRLQRARTILEF 703
>gi|9966865 transient receptor potential cation channel, subfamily C,
member 7 [Homo sapiens]
Length = 862
Score = 40.8 bits (94), Expect = 0.008
Identities = 41/205 (20%), Positives = 87/205 (42%), Gaps = 39/205 (19%)
Query: 905 RLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILR 964
R+ +I N+ GP + + + +KD+F F+ + VA+ + L S R
Sbjct: 554 RIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLY--------SYYR 605
Query: 965 RVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLV---- 1020
Y P + S + FW+ ++ + V +Y + +
Sbjct: 606 GAKYNPAFTTVEE----------------SFKTLFWSIFGLSEVISVVLKYDHKFIENIG 649
Query: 1021 VLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPF 1079
+L ++ + ++L+N+LIAM + ++ +++ ++D+ WK R +L + F L PF
Sbjct: 650 YVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPF 709
Query: 1080 ----------IVISHLRLLLRQLCR 1094
+I +++ L +LC+
Sbjct: 710 NLVPSPKSFYYLIMRIKMCLIKLCK 734
>gi|5730102 transient receptor potential cation channel, subfamily C,
member 6 [Homo sapiens]
Length = 931
Score = 40.0 bits (92), Expect = 0.013
Identities = 40/183 (21%), Positives = 79/183 (43%), Gaps = 29/183 (15%)
Query: 905 RLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILR 964
R+ +I N+ GP + + + +KD+F F+ + VA+ + L
Sbjct: 609 RIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNL------------- 655
Query: 965 RVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLV---- 1020
Y Y+ Q + + E S + FWA ++ + V Y + +
Sbjct: 656 ---YSYYIGA----KQNEAFTTVEE----SFKTLFWAIFGLSEVKSVVINYNHKFIENIG 704
Query: 1021 VLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRL-IREFHSRPALAPPF 1079
+L ++ + I+L+N+LIAM + +F +++ ++D+ WK R +L F L PF
Sbjct: 705 YVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPF 764
Query: 1080 IVI 1082
++
Sbjct: 765 NLV 767
>gi|20127551 transient receptor potential cation channel, subfamily V,
member 2 [Homo sapiens]
Length = 764
Score = 38.5 bits (88), Expect = 0.039
Identities = 19/44 (43%), Positives = 30/44 (68%)
Query: 1019 LVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQR 1062
+V+LLL+ ++L+ ILL+N+LIA+ S T V +S WK Q+
Sbjct: 621 MVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQK 664
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.435
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,524,153
Number of Sequences: 37866
Number of extensions: 2532967
Number of successful extensions: 9681
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 9432
Number of HSP's gapped (non-prelim): 140
length of query: 1214
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1100
effective length of database: 13,930,794
effective search space: 15323873400
effective search space used: 15323873400
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.