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Search of human proteins with 21264616
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|21264616 epidermal growth factor receptor pathway substrate
8-like protein 2 [Homo sapiens]
(715 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|21264616 epidermal growth factor receptor pathway substrate 8... 1449 0.0
gi|56682953 epidermal growth factor receptor pathway substrate 8... 565 e-161
gi|148539853 epidermal growth factor receptor pathway substrate ... 457 e-128
gi|148539855 epidermal growth factor receptor pathway substrate ... 347 3e-95
gi|21071016 epidermal growth factor receptor pathway substrate 8... 268 1e-71
gi|21071018 epidermal growth factor receptor pathway substrate 8... 268 2e-71
gi|21071014 epidermal growth factor receptor pathway substrate 8... 258 2e-68
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 59 2e-08
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 49 2e-05
gi|20149528 proline-serine-threonine phosphatase interacting pro... 49 2e-05
gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens] 48 3e-05
gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens] 48 3e-05
gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens] 48 3e-05
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 48 4e-05
gi|182765466 FCH and double SH3 domains 2 [Homo sapiens] 48 4e-05
gi|189083742 neutrophil cytosolic factor 2 [Homo sapiens] 45 2e-04
gi|67189970 neutrophil cytosolic factor 2 [Homo sapiens] 45 2e-04
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 45 2e-04
gi|5453754 NCK adaptor protein 1 [Homo sapiens] 45 2e-04
gi|15718680 IL2-inducible T-cell kinase [Homo sapiens] 44 5e-04
gi|18250298 src-related kinase lacking C-terminal regulatory tyr... 43 9e-04
gi|24308229 protein kinase C and casein kinase substrate in neur... 43 9e-04
gi|187155251 hypothetical protein LOC79078 [Homo sapiens] 43 9e-04
gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a ... 42 0.002
gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b ... 42 0.002
gi|63055059 SH3 and PX domains 2B [Homo sapiens] 42 0.002
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 42 0.002
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 42 0.002
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 42 0.003
gi|199559490 Abelson helper integration site 1 isoform a [Homo s... 42 0.003
>gi|21264616 epidermal growth factor receptor pathway substrate
8-like protein 2 [Homo sapiens]
Length = 715
Score = 1449 bits (3750), Expect = 0.0
Identities = 715/715 (100%), Positives = 715/715 (100%)
Query: 1 MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATF 60
MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATF
Sbjct: 1 MSQSGAVSCCPGATNGSLGRSDGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATF 60
Query: 61 IMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTV 120
IMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTV
Sbjct: 61 IMDKSEAITSVDDAIRKLVQLSSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTV 120
Query: 121 QRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKM 180
QRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKM
Sbjct: 121 QRSQTVLNQLRYPSVLLLVCQDSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKM 180
Query: 181 RPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRES 240
RPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRES
Sbjct: 181 RPQTLKGHQEKIRQRQSILPPPQGPAPIPFQHRGGDSPEAKNRVGPQVPLSEPGFRRRES 240
Query: 241 QEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEG 300
QEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEG
Sbjct: 241 QEEPRAVLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEG 300
Query: 301 VLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSG 360
VLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSG
Sbjct: 301 VLTLRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSG 360
Query: 361 PDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFH 420
PDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFH
Sbjct: 361 PDIARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFH 420
Query: 421 SGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSS 480
SGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSS
Sbjct: 421 SGWEPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSS 480
Query: 481 PHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGY 540
PHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGY
Sbjct: 481 PHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGY 540
Query: 541 VPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRK 600
VPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRK
Sbjct: 541 VPCNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRK 600
Query: 601 ISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFS 660
ISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFS
Sbjct: 601 ISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFS 660
Query: 661 LNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS 715
LNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS
Sbjct: 661 LNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRGEDS 715
>gi|56682953 epidermal growth factor receptor pathway substrate 8
[Homo sapiens]
Length = 822
Score = 565 bits (1456), Expect = e-161
Identities = 331/783 (42%), Positives = 452/783 (57%), Gaps = 100/783 (12%)
Query: 25 AKMSPKDLFEQRKKYSNSNVI-MHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSS 83
+K S K L+EQRK Y+ +V + + SQY V+HL TF++D+ +A+ +VDD IRKL L +
Sbjct: 37 SKTSAKALYEQRKNYARDSVSSVSDISQYRVEHLTTFVLDRKDAMITVDDGIRKLKLLDA 96
Query: 84 KEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDS 143
K K+WTQ+M+LQV+D+++ L+D+ES+ ELE+FPL T+Q Q V++ Y SVL LVC++
Sbjct: 97 KGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTIQHCQAVMHSCSYDSVLALVCKEP 156
Query: 144 EQSKPDVHFFHCDEVEAELVHEDIESALADCRLGK-KMRPQTLKGHQEKIRQRQSILPPP 202
Q+KPD+H F CDEV+A L+ EDIESA++D + GK K RP L+ SI PPP
Sbjct: 157 TQNKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPDALRMISNA---DPSIPPPP 213
Query: 203 QGPAPIPFQHRGGDSPEAKNRVGP-------QVPLSEPGFRRRESQEEPRAVLAQKIEKE 255
+ PAP P + ++RV Q +P R+ QEE ++A +I+++
Sbjct: 214 RAPAPAP--PGTVTQVDVRSRVAAWSAWAADQGDFEKP--RQYHEQEETPEMMAARIDRD 269
Query: 256 TQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFI 315
QILN LDDIE+F+ +LQKAAEAF +L++RKK KK +K P EGVLTLRA+PP EF+
Sbjct: 270 VQILNHILDDIEFFITKLQKAAEAFSELSKRKKNKKGKRKGPGEGVLTLRAKPPPPDEFL 329
Query: 316 DCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRD 375
DCFQK K NLLAKL+ HIQNPSAA+LVHFLF PL+++V GP++A SV PLL++D
Sbjct: 330 DCFQKFKHGFNLLAKLKSHIQNPSAADLVHFLFTPLNMVVQATGGPELASSVLSPLLNKD 389
Query: 376 AVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPW 435
+DFL + E LW SLG +WM+ R+EWP+E +P YVP+F +GWEPP+ A
Sbjct: 390 TIDFLNYTVNGDERQLWMSLGGTWMKARAEWPKEQFIPPYVPRFRNGWEPPMLNFMGATM 449
Query: 436 EVE--GLASAPIEEVSPVSRQSI-RNSQKHSPTSEPTPPGD------------------- 473
E + LA + +Q I R S +HS SE P
Sbjct: 450 EQDLYQLAESVANVAEHQRKQEIKRLSTEHSSVSEYHPADGYAFSSNIYTRGSHLDQGEA 509
Query: 474 --ALPPVSSPHTHRGYQPTPAM-AKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWK 530
A P S+ H R Y+P KY K YDF ARN +ELSVLKD++LE+L+D +QWWK
Sbjct: 510 AVAFKPTSNRHIDRNYEPLKTQPKKYAKSKYDFVARNNSELSVLKDDILEILDDRKQWWK 569
Query: 531 LRSRSGQAGYVPCNILGEARPEDAG-----APFEQAGQKY---WG--------------- 567
+R+ SG +G+VP NIL RP ++G P+ QK +G
Sbjct: 570 VRNASGDSGFVPNNILDIVRPPESGLGRADPPYTHTIQKQRMEYGPRPADTPPAPSPPPT 629
Query: 568 PASPTHKLPPSFPG-----------------------------------NKDELMQHMDE 592
PA LPPS P D M+E
Sbjct: 630 PAPVPVPLPPSTPAPVPVSKVPANITRQNSSSSDSGGSIVRDSQRHKQLPVDRRKSQMEE 689
Query: 593 VNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGI 652
V DELI +++ R+ Q+ F V R +TY+S P++V+ WL++K F+P V +LG+
Sbjct: 690 VQDELIHRLTIGRSAAQKKFHVPRQNVPVINITYDSTPEDVKTWLQSKGFNPVTVNSLGV 749
Query: 653 LTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNKFHSMNQRRG 712
L G QLFSLNK+EL+ VC EG RVYSQ+T+QKA LE SEL+E+M +
Sbjct: 750 LNGAQLFSLNKDELRTVC-PEGARVYSQITVQKAALEDSSGSSELQEIMRRRQEKISAAA 808
Query: 713 EDS 715
DS
Sbjct: 809 SDS 811
>gi|148539853 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform a [Homo sapiens]
Length = 723
Score = 457 bits (1177), Expect = e-128
Identities = 293/723 (40%), Positives = 406/723 (56%), Gaps = 62/723 (8%)
Query: 22 DGVAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQL 81
+ K S K ++EQRK+YS V+M + SQY V HL TF + + + + +V+DA RKL +
Sbjct: 8 EAAPKPSAKSIYEQRKRYST--VVMADVSQYPVNHLVTFCLGEDDGVHTVEDASRKLAVM 65
Query: 82 SSKEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQ 141
S+ ++W QEMLL+V+ + LLD S+EELE +PL + R V+ R S+LLLVCQ
Sbjct: 66 DSQGRVWAQEMLLRVSPDHVTLLDPASKEELESYPLGAIVRCDAVMPPGRSRSLLLLVCQ 125
Query: 142 DSEQSKPDVHFFHCDEVEAELVHEDIESALADCRLGK-KMRPQTLKGHQEKIRQRQSIL- 199
+ E+++PDVHFF + AEL+ EDI+ AL + R G+ + R L+ QE++++ +S
Sbjct: 126 EPERAQPDVHFFQGLRLGAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAA 185
Query: 200 --PP----PQGPAPIPFQHRGGDS--------PEAKNRVGPQVPLSEPGFRRRESQEEPR 245
PP P A I RG PEA+ P+ + PR
Sbjct: 186 ETPPLQRRPSVRAVISTVERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPR 245
Query: 246 A--VLAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLT 303
+ + E+E ILN DD+E FV+RLQK+AEA + L R++G++ ++A EG+LT
Sbjct: 246 GPDLAVLQAEREVDILNHVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLT 305
Query: 304 LRARPPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDI 363
LRA+PPSE E+ D QKIK A +LLA+L+ +I +PS+ EL+HFLFGPL +IVNT GP+
Sbjct: 306 LRAKPPSEAEYTDVLQKIKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEF 365
Query: 364 ARSVSCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGW 423
A SV P L+ DAV LR ++ P+E LW SLG+SW RP E E + P Y P+F SGW
Sbjct: 366 ASSVRRPHLTSDAVALLRDNVTPRENELWTSLGDSWTRPGLELSPE-EGPPYRPEFFSGW 424
Query: 424 EPPVDVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHT 483
EPPV Q WE P+E+ R R Q+ +P D L P S P
Sbjct: 425 EPPVTDPQSRAWE------DPVEKQLQHER---RRRQQSAPQVAVNGHRD-LEPESEPQL 474
Query: 484 HRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPC 543
+ K+V YDF ARN++ELSV + +VLEVL+D R+WWK+R +GQ GYVP
Sbjct: 475 E-----SETAGKWVLCNYDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPY 529
Query: 544 NILGE---ARPEDAGAPFEQAGQKYWGPASPTHKLPPSF--------------------P 580
NIL R + +P P +P PP+ P
Sbjct: 530 NILTPYPGPRLHHSQSPARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDP 589
Query: 581 GNKDELMQHMDEVNDELIRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAK 640
K++ Q M VN+EL +++ R+ P R V + L+ S EVRAWL+AK
Sbjct: 590 SEKEKFSQ-MLIVNEELQARLAQGRSGPSR--AVPGPRAPEPQLSPGSDASEVRAWLQAK 646
Query: 641 AFSPRIVENLGILTGPQLFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEEL 700
FS V+ LG+LTG QLFSL KEEL+ V EEG RVYSQ+T+Q++ LE ++ SELE +
Sbjct: 647 GFSSGTVDALGVLTGAQLFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAV 706
Query: 701 MNK 703
M K
Sbjct: 707 MEK 709
>gi|148539855 epidermal growth factor receptor pathway substrate
8-like protein 1 isoform b [Homo sapiens]
Length = 596
Score = 347 bits (889), Expect = 3e-95
Identities = 234/586 (39%), Positives = 318/586 (54%), Gaps = 60/586 (10%)
Query: 159 EAELVHEDIESALADCRLGK-KMRPQTLKGHQEKIRQRQSIL---PP----PQGPAPIPF 210
EAEL+ EDI+ AL + R G+ + R L+ QE++++ +S PP P A I
Sbjct: 16 EAELIREDIQGALHNYRSGRGERRAAALRATQEELQRDRSPAAETPPLQRRPSVRAVIST 75
Query: 211 QHRGGDS--------PEAKNRVGPQVPLSEPGFRRRESQEEPRA--VLAQKIEKETQILN 260
RG PEA+ P+ + PR + + E+E ILN
Sbjct: 76 VERGAGRGRPQAKPIPEAEEAQRPEPVGTSSNADSASPDLGPRGPDLAVLQAEREVDILN 135
Query: 261 CALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRARPPSEGEFIDCFQK 320
DD+E FV+RLQK+AEA + L R++G++ ++A EG+LTLRA+PPSE E+ D QK
Sbjct: 136 HVFDDVESFVSRLQKSAEAARVLEHRERGRRSRRRAAGEGLLTLRAKPPSEAEYTDVLQK 195
Query: 321 IKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSVSCPLLSRDAVDFL 380
IK A +LLA+L+ +I +PS+ EL+HFLFGPL +IVNT GP+ A SV P L+ DAV L
Sbjct: 196 IKYAFSLLARLRGNIADPSSPELLHFLFGPLQMIVNTSGGPEFASSVRRPHLTSDAVALL 255
Query: 381 RGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPVDVLQEAPWEVEGL 440
R ++ P+E LW SLG+SW RP E E + P Y P+F SGWEPPV Q WE
Sbjct: 256 RDNVTPRENELWTSLGDSWTRPGLELSPE-EGPPYRPEFFSGWEPPVTDPQSRAWE---- 310
Query: 441 ASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKIL 500
P+E+ R R Q+ +P D L P S P + K+V
Sbjct: 311 --DPVEKQLQHER---RRRQQSAPQVAVNGHRD-LEPESEPQLE-----SETAGKWVLCN 359
Query: 501 YDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGE---ARPEDAGAP 557
YDF ARN++ELSV + +VLEVL+D R+WWK+R +GQ GYVP NIL R + +P
Sbjct: 360 YDFQARNSSELSVKQRDVLEVLDDSRKWWKVRDPAGQEGYVPYNILTPYPGPRLHHSQSP 419
Query: 558 FEQAGQKYWGPASPTHKLPPSF--------------------PGNKDELMQHMDEVNDEL 597
P +P PP+ P K++ Q M VN+EL
Sbjct: 420 ARSLNSTPPPPPAPAPAPPPALARPRWDRPRWDSCDSLNGLDPSEKEKFSQ-MLIVNEEL 478
Query: 598 IRKISNIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQ 657
+++ R+ P R V + L+ S EVRAWL+AK FS V+ LG+LTG Q
Sbjct: 479 QARLAQGRSGPSR--AVPGPRAPEPQLSPGSDASEVRAWLQAKGFSSGTVDALGVLTGAQ 536
Query: 658 LFSLNKEELKKVCGEEGVRVYSQLTMQKAFLEKQQSGSELEELMNK 703
LFSL KEEL+ V EEG RVYSQ+T+Q++ LE ++ SELE +M K
Sbjct: 537 LFSLQKEELRAVSPEEGARVYSQVTVQRSLLEDKEKVSELEAVMEK 582
>gi|21071016 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform b [Homo sapiens]
Length = 593
Score = 268 bits (686), Expect = 1e-71
Identities = 210/686 (30%), Positives = 325/686 (47%), Gaps = 118/686 (17%)
Query: 24 VAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSS 83
+++ S + ++ RK+YS + Q+ V+HL T S+ + +DA++KL ++ +
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDA 59
Query: 84 KEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDS 143
+ ++W+Q+++LQV D L+LLDIE++EEL+ + L ++Q LN Y S+L + Q+
Sbjct: 60 QGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEP 119
Query: 144 EQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIR---------- 193
F C EV AE + ++ AL + L ++ R L+ Q++ R
Sbjct: 120 GLPGTSTLLFQCQEVGAERLKTSLQKALEE-ELEQRPRLGGLQPGQDRWRGPAMERPLPM 178
Query: 194 -QRQSILP--PPQGPAPIPFQHRGGDSPEAKNR-VGPQVP--LSEPGFRRRESQEEPRAV 247
Q + + P PP+ P +H SP R + P + P RR S E+P
Sbjct: 179 EQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDP--- 235
Query: 248 LAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRAR 307
E++ ++LN L DIE F+ +L+KA + + KK GKK +G LT
Sbjct: 236 -----ERDEEVLNHVLRDIELFMGKLEKAQA------KTSRKKKFGKKNKDQGGLT---- 280
Query: 308 PPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSV 367
+ ++IDCFQKIK + NLL +L ++ SA ELVH LF L+ I+ C +A V
Sbjct: 281 ---QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQV 337
Query: 368 SCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPV 427
PLL+ A++ L+ L P E +LW LG +W R++W + +P Y P F W+ P
Sbjct: 338 ISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLP-YQPTFSDDWQLP- 395
Query: 428 DVLQEAPWEVEGLASAPIEEVSPVS--RQSIR-NSQKHSPTSEPTPPGDALP--PVSSPH 482
E + AP+ PVS R S R S H P E T D P P S P
Sbjct: 396 ----------EPSSQAPLGYQDPVSLRRGSHRLGSTSHFP-QEKTHNHDPQPGDPNSRPS 444
Query: 483 THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVP 542
+ + QP A +++LY+F ARN EL+V++ E LEVL+ ++WW +++ +G++GY+P
Sbjct: 445 SPKPAQP----ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIP 500
Query: 543 CNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKIS 602
NIL L P PG
Sbjct: 501 SNIL--------------------------EPLQPGTPG--------------------- 513
Query: 603 NIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN 662
Q Q RV + S+P +EV WL+A+ FS V LG LTG QL +
Sbjct: 514 ---TQGQSPSRVPMLRLSSRP-------EEVTDWLQAENFSTATVRTLGSLTGSQLLRIR 563
Query: 663 KEELKKVCGEEGVRVYSQLTMQKAFL 688
EL+ +C +E R+ S+L + L
Sbjct: 564 PGELQMLCPQEAPRILSRLEAVRRML 589
>gi|21071018 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform a [Homo sapiens]
Length = 594
Score = 268 bits (684), Expect = 2e-71
Identities = 209/686 (30%), Positives = 323/686 (47%), Gaps = 117/686 (17%)
Query: 24 VAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSS 83
+++ S + ++ RK+YS + Q+ V+HL T S+ + +DA++KL ++ +
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDA 59
Query: 84 KEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDS 143
+ ++W+Q+++LQV D L+LLDIE++EEL+ + L ++Q LN Y S+L + Q+
Sbjct: 60 QGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEP 119
Query: 144 EQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIR---------- 193
F C EV AE + ++ AL + + R L+ Q++ R
Sbjct: 120 GLPGTSTLLFQCQEVGAERLKTSLQKALEEELEQSRPRLGGLQPGQDRWRGPAMERPLPM 179
Query: 194 -QRQSILP--PPQGPAPIPFQHRGGDSPEAKNR-VGPQVP--LSEPGFRRRESQEEPRAV 247
Q + + P PP+ P +H SP R + P + P RR S E+P
Sbjct: 180 EQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDP--- 236
Query: 248 LAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRAR 307
E++ ++LN L DIE F+ +L+KA + + KK GKK +G LT
Sbjct: 237 -----ERDEEVLNHVLRDIELFMGKLEKAQA------KTSRKKKFGKKNKDQGGLT---- 281
Query: 308 PPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSV 367
+ ++IDCFQKIK + NLL +L ++ SA ELVH LF L+ I+ C +A V
Sbjct: 282 ---QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQV 338
Query: 368 SCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPV 427
PLL+ A++ L+ L P E +LW LG +W R++W + +P Y P F W+ P
Sbjct: 339 ISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLP-YQPTFSDDWQLP- 396
Query: 428 DVLQEAPWEVEGLASAPIEEVSPVS--RQSIR-NSQKHSPTSEPTPPGDALP--PVSSPH 482
E + AP+ PVS R S R S H P E T D P P S P
Sbjct: 397 ----------EPSSQAPLGYQDPVSLRRGSHRLGSTSHFP-QEKTHNHDPQPGDPNSRPS 445
Query: 483 THRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVP 542
+ + QP A +++LY+F ARN EL+V++ E LEVL+ ++WW +++ +G++GY+P
Sbjct: 446 SPKPAQP----ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIP 501
Query: 543 CNILGEARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKIS 602
NIL L P PG
Sbjct: 502 SNIL--------------------------EPLQPGTPG--------------------- 514
Query: 603 NIRAQPQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLN 662
Q Q RV + S+P +EV WL+A+ FS V LG LTG QL +
Sbjct: 515 ---TQGQSPSRVPMLRLSSRP-------EEVTDWLQAENFSTATVRTLGSLTGSQLLRIR 564
Query: 663 KEELKKVCGEEGVRVYSQLTMQKAFL 688
EL+ +C +E R+ S+L + L
Sbjct: 565 PGELQMLCPQEAPRILSRLEAVRRML 590
>gi|21071014 epidermal growth factor receptor pathway substrate
8-like protein 3 isoform c [Homo sapiens]
Length = 563
Score = 258 bits (658), Expect = 2e-68
Identities = 199/681 (29%), Positives = 314/681 (46%), Gaps = 138/681 (20%)
Query: 24 VAKMSPKDLFEQRKKYSNSNVIMHETSQYHVQHLATFIMDKSEAITSVDDAIRKLVQLSS 83
+++ S + ++ RK+YS + Q+ V+HL T S+ + +DA++KL ++ +
Sbjct: 1 MSRPSSRAIYLHRKEYSQNLTSEPTLLQHRVEHLMT-CKQGSQRVQGPEDALQKLFEMDA 59
Query: 84 KEKIWTQEMLLQVNDQSLRLLDIESQEELEDFPLPTVQRSQTVLNQLRYPSVLLLVCQDS 143
+ ++W+Q+++LQV D L+LLDIE++EEL+ + L ++Q LN Y S+L + Q+
Sbjct: 60 QGRVWSQDLILQVRDGWLQLLDIETKEELDSYRLDSIQAMNVALNTCSYNSILSITVQEP 119
Query: 144 EQSKPDVHFFHCDEVEAELVHEDIESALADCRLGKKMRPQTLKGHQEKIR---------- 193
F C EV AE + ++ AL + L ++ R L+ Q++ R
Sbjct: 120 GLPGTSTLLFQCQEVGAERLKTSLQKALEE-ELEQRPRLGGLQPGQDRWRGPAMERPLPM 178
Query: 194 -QRQSILP--PPQGPAPIPFQHRGGDSPEAKNR-VGPQVP--LSEPGFRRRESQEEPRAV 247
Q + + P PP+ P +H SP R + P + P RR S E+P
Sbjct: 179 EQARYLEPGIPPEQPHQRTLEHSLPPSPRPLPRHTSAREPSAFTLPPPRRSSSPEDP--- 235
Query: 248 LAQKIEKETQILNCALDDIEWFVARLQKAAEAFKQLNQRKKGKKKGKKAPAEGVLTLRAR 307
E++ ++LN L DIE F+ +L+KA + + KK GKK +G LT
Sbjct: 236 -----ERDEEVLNHVLRDIELFMGKLEKAQA------KTSRKKKFGKKNKDQGGLT---- 280
Query: 308 PPSEGEFIDCFQKIKLAINLLAKLQKHIQNPSAAELVHFLFGPLDLIVNTCSGPDIARSV 367
+ ++IDCFQKIK + NLL +L ++ SA ELVH LF L+ I+ C +A V
Sbjct: 281 ---QAQYIDCFQKIKHSFNLLGRLATWLKETSAPELVHILFKSLNFILARCPEAGLAAQV 337
Query: 368 SCPLLSRDAVDFLRGHLVPKEMSLWESLGESWMRPRSEWPREPQVPLYVPKFHSGWEPPV 427
PLL+ A++ L+ L P E +LW LG +W R++W + +P Y P F W+ P
Sbjct: 338 ISPLLTPKAINLLQSCLSPPESNLWMGLGPAWTTSRADWTGDEPLP-YQPTFSDDWQLP- 395
Query: 428 DVLQEAPWEVEGLASAPIEEVSPVSRQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGY 487
E + AP+ PVS + P+ P A P
Sbjct: 396 ----------EPSSQAPLGYQDPVSLR-------------PSSPKPAQP----------- 421
Query: 488 QPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILG 547
A +++LY+F ARN EL+V++ E LEVL+ ++WW +++ +G++GY+P NIL
Sbjct: 422 ------ALKMQVLYEFEARNPRELTVVQGEKLEVLDHSKRWWLVKNEAGRSGYIPSNIL- 474
Query: 548 EARPEDAGAPFEQAGQKYWGPASPTHKLPPSFPGNKDELMQHMDEVNDELIRKISNIRAQ 607
L P PG Q
Sbjct: 475 -------------------------EPLQPGTPG------------------------TQ 485
Query: 608 PQRHFRVERSQPVSQPLTYESGPDEVRAWLEAKAFSPRIVENLGILTGPQLFSLNKEELK 667
Q RV + S+P +EV WL+A+ FS V LG LTG QL + EL+
Sbjct: 486 GQSPSRVPMLRLSSRP-------EEVTDWLQAENFSTATVRTLGSLTGSQLLRIRPGELQ 538
Query: 668 KVCGEEGVRVYSQLTMQKAFL 688
+C +E R+ S+L + L
Sbjct: 539 MLCPQEAPRILSRLEAVRRML 559
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 58.5 bits (140), Expect = 2e-08
Identities = 34/103 (33%), Positives = 49/103 (47%), Gaps = 12/103 (11%)
Query: 455 SIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMA-------KYVKILYDFTARN 507
S++ H T +P PP P + P PA A K V LYD+ N
Sbjct: 174 SLKPGSSHRKTKKPLPP----TPEEDQILKKPLPPEPAAAPVSTSELKKVVALYDYMPMN 229
Query: 508 ANELSVLKDEVLEVLEDGR-QWWKLRSRSGQAGYVPCNILGEA 549
AN+L + K + +LE+ WW+ R ++GQ GY+P N + EA
Sbjct: 230 ANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVTEA 272
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 48.9 bits (115), Expect = 2e-05
Identities = 24/52 (46%), Positives = 33/52 (63%), Gaps = 1/52 (1%)
Query: 496 YVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSR-SGQAGYVPCNIL 546
+V LYD+TA N +L +LK E L+VL+ WW RS +G+ GYVP N +
Sbjct: 62 FVVALYDYTAMNDRDLQMLKGEKLQVLKGTGDWWLARSLVTGREGYVPSNFV 113
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 48.5 bits (114), Expect = 2e-05
Identities = 43/154 (27%), Positives = 72/154 (46%), Gaps = 18/154 (11%)
Query: 409 EPQVPLYVPKFHSGWEPPVDVLQEAPW--EVEGLASAPIEEVS--PVSRQS--IRNSQKH 462
+ + ++ +G EPP V + + EV L S+P + S + R S + S K
Sbjct: 262 DADIDSFIQAKSTGTEPPAPVPYQNYYDREVTPLTSSPGIQPSCGMIKRFSGLLHGSPKT 321
Query: 463 SPTSEPTPPGDALPPVSSPHTHRGY---------QPTPAM-AKYVKILYDFTARNANELS 512
+ + + L P +P + G Q PA A+ + LYD+TA+N +EL
Sbjct: 322 TSLAASAASTETLTP--TPERNEGVYTAIAVQEIQGNPASPAQEYRALYDYTAQNPDELD 379
Query: 513 VLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNIL 546
+ ++LEV+ +G W R+GQ G+VP + L
Sbjct: 380 LSAGDILEVILEGEDGWWTVERNGQRGFVPGSYL 413
>gi|52630427 NCK adaptor protein 2 isoform B [Homo sapiens]
Length = 83
Score = 48.1 bits (113), Expect = 3e-05
Identities = 18/44 (40%), Positives = 31/44 (70%)
Query: 501 YDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCN 544
+D+TA+ EL + K+E L +L+D + WW++R+ + + GYVP N
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54
>gi|52630425 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 48.1 bits (113), Expect = 3e-05
Identities = 18/44 (40%), Positives = 31/44 (70%)
Query: 501 YDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCN 544
+D+TA+ EL + K+E L +L+D + WW++R+ + + GYVP N
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54
Score = 43.9 bits (102), Expect = 5e-04
Identities = 26/77 (33%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 497 VKILYDFTARNANELSVLKDEVLEVLE---DGRQWWKLRSRSGQAGYVPCNILGEARPED 553
V+ LY F++ EL+ K E +EV+E + +WWK ++ GQ G VP N +
Sbjct: 200 VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGP 259
Query: 554 AGAPFEQAGQKYWGPAS 570
A P Y GP+S
Sbjct: 260 ALHPAHAPQISYTGPSS 276
Score = 38.1 bits (87), Expect = 0.029
Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 6/90 (6%)
Query: 466 SEPTPPGDALPPVSSPHTHRGYQPT-PAMAKYVKILYDFTARNANELSVLKDEVLEVLED 524
+ PTP DA P + R Y PA K+ + A +ELS++K + V+E
Sbjct: 89 ASPTPSTDAEYPANGSGADRIYDLNIPAFVKFA-----YVAEREDELSLVKGSRVTVMEK 143
Query: 525 GRQWWKLRSRSGQAGYVPCNILGEARPEDA 554
W S +GQ G+ P N + E E A
Sbjct: 144 CSDGWWRGSYNGQIGWFPSNYVLEEVDEAA 173
>gi|52630423 NCK adaptor protein 2 isoform A [Homo sapiens]
Length = 380
Score = 48.1 bits (113), Expect = 3e-05
Identities = 18/44 (40%), Positives = 31/44 (70%)
Query: 501 YDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCN 544
+D+TA+ EL + K+E L +L+D + WW++R+ + + GYVP N
Sbjct: 11 WDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSN 54
Score = 43.9 bits (102), Expect = 5e-04
Identities = 26/77 (33%), Positives = 38/77 (49%), Gaps = 3/77 (3%)
Query: 497 VKILYDFTARNANELSVLKDEVLEVLE---DGRQWWKLRSRSGQAGYVPCNILGEARPED 553
V+ LY F++ EL+ K E +EV+E + +WWK ++ GQ G VP N +
Sbjct: 200 VQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGP 259
Query: 554 AGAPFEQAGQKYWGPAS 570
A P Y GP+S
Sbjct: 260 ALHPAHAPQISYTGPSS 276
Score = 38.1 bits (87), Expect = 0.029
Identities = 28/90 (31%), Positives = 40/90 (44%), Gaps = 6/90 (6%)
Query: 466 SEPTPPGDALPPVSSPHTHRGYQPT-PAMAKYVKILYDFTARNANELSVLKDEVLEVLED 524
+ PTP DA P + R Y PA K+ + A +ELS++K + V+E
Sbjct: 89 ASPTPSTDAEYPANGSGADRIYDLNIPAFVKFA-----YVAEREDELSLVKGSRVTVMEK 143
Query: 525 GRQWWKLRSRSGQAGYVPCNILGEARPEDA 554
W S +GQ G+ P N + E E A
Sbjct: 144 CSDGWWRGSYNGQIGWFPSNYVLEEVDEAA 173
>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
[Homo sapiens]
Length = 303
Score = 47.8 bits (112), Expect = 4e-05
Identities = 28/80 (35%), Positives = 42/80 (52%), Gaps = 9/80 (11%)
Query: 467 EPTP--PGDALPPVSSPHTHRGYQPTPA-MAKYVKILYDFTARNANELSVLKDEVLEVLE 523
EP P P + VS+P+ PT +YV+ LYDF +A +L K E+L ++E
Sbjct: 100 EPAPRYPSPPMGSVSAPNL-----PTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIE 154
Query: 524 -DGRQWWKLRSRSGQAGYVP 542
QWW R++ G+ G +P
Sbjct: 155 KPEEQWWSARNKDGRVGMIP 174
>gi|182765466 FCH and double SH3 domains 2 [Homo sapiens]
Length = 740
Score = 47.8 bits (112), Expect = 4e-05
Identities = 22/47 (46%), Positives = 32/47 (68%), Gaps = 2/47 (4%)
Query: 498 KILYDFTARNANELSVLKDEVLEVLEDG--RQWWKLRSRSGQAGYVP 542
K++Y + A +EL++ + EVLEV+EDG W K R++ GQ GYVP
Sbjct: 475 KVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVP 521
>gi|189083742 neutrophil cytosolic factor 2 [Homo sapiens]
Length = 526
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/123 (30%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 468 PTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQ 527
P P A PP P T ++ A ++L+ F EL V+ ++ VL+ G
Sbjct: 219 PLQPQAAEPP-PRPKTPEIFRALEGEAH--RVLFGFVPETKEELQVMPGNIVFVLKKGND 275
Query: 528 WWKLRSRSGQAGYVPCNILG--EARPEDAGAPFEQAGQKYWGPASPTHKLP--PSF-PGN 582
W +GQ G VPCN L E R P E++ + PA P+ K P P PG
Sbjct: 276 NWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQ 335
Query: 583 KDE 585
K +
Sbjct: 336 KQK 338
>gi|67189970 neutrophil cytosolic factor 2 [Homo sapiens]
Length = 526
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/123 (30%), Positives = 53/123 (43%), Gaps = 8/123 (6%)
Query: 468 PTPPGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQ 527
P P A PP P T ++ A ++L+ F EL V+ ++ VL+ G
Sbjct: 219 PLQPQAAEPP-PRPKTPEIFRALEGEAH--RVLFGFVPETKEELQVMPGNIVFVLKKGND 275
Query: 528 WWKLRSRSGQAGYVPCNILG--EARPEDAGAPFEQAGQKYWGPASPTHKLP--PSF-PGN 582
W +GQ G VPCN L E R P E++ + PA P+ K P P PG
Sbjct: 276 NWATVMFNGQKGLVPCNYLEPVELRIHPQQQPQEESSPQSDIPAPPSSKAPGRPQLSPGQ 335
Query: 583 KDE 585
K +
Sbjct: 336 KQK 338
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/89 (30%), Positives = 45/89 (50%), Gaps = 2/89 (2%)
Query: 458 NSQKHSPTSEPTPPGDALPPVSSPHTHR-GYQPTPAMAKYVKILYDFTARNANELSVLKD 516
++ H P P P P +S +++ G + + V LYD+ A + +LS K
Sbjct: 43 SASPHCPVYVPDPTSTIKPGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKG 102
Query: 517 EVLEVLEDGRQWWKLRS-RSGQAGYVPCN 544
+ + VLE+ +WWK RS + + GY+P N
Sbjct: 103 DQMVVLEESGEWWKARSLATRKEGYIPSN 131
>gi|5453754 NCK adaptor protein 1 [Homo sapiens]
Length = 377
Score = 45.4 bits (106), Expect = 2e-04
Identities = 19/54 (35%), Positives = 35/54 (64%), Gaps = 2/54 (3%)
Query: 493 MAKYVKIL--YDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCN 544
MA+ V ++ +D+ A+ EL + K+E L +L+D + WW++R+ + G+VP N
Sbjct: 1 MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSN 54
Score = 41.6 bits (96), Expect = 0.003
Identities = 20/51 (39%), Positives = 31/51 (60%), Gaps = 3/51 (5%)
Query: 497 VKILYDFTARNANELSVLKDEVLEVLE---DGRQWWKLRSRSGQAGYVPCN 544
V+ LY F++ N EL+ K +V++V+E + +WWK R +G G VP N
Sbjct: 195 VQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKN 245
Score = 33.5 bits (75), Expect = 0.71
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 493 MAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRSRSGQAGYVPCNILGE 548
M YVK +++ A +ELS++K + V+E W S +GQ G+ P N + E
Sbjct: 109 MPAYVK--FNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQVGWFPSNYVTE 162
>gi|15718680 IL2-inducible T-cell kinase [Homo sapiens]
Length = 620
Score = 43.9 bits (102), Expect = 5e-04
Identities = 23/80 (28%), Positives = 41/80 (51%), Gaps = 4/80 (5%)
Query: 475 LPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGR-QWWKLRS 533
LPP + ++P + V LYD+ + EL++ ++E +L+ WW+++
Sbjct: 157 LPPTPEDNRRPLWEPEETV---VIALYDYQTNDPQELALRRNEEYCLLDSSEIHWWRVQD 213
Query: 534 RSGQAGYVPCNILGEARPED 553
R+G GYVP + L E P +
Sbjct: 214 RNGHEGYVPSSYLVEKSPNN 233
>gi|18250298 src-related kinase lacking C-terminal regulatory
tyrosine and N-terminal myristylation sites [Homo
sapiens]
Length = 488
Score = 43.1 bits (100), Expect = 9e-04
Identities = 32/84 (38%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 471 PGDALPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWK 530
PG +L P + P +P + LYDFTAR ELSV + + L LE+G +
Sbjct: 31 PG-SLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIF 89
Query: 531 LRSRSGQ--AGYVPCNILGEARPE 552
R SGQ AG VP + +A PE
Sbjct: 90 ARRLSGQPSAGLVPITHVAKASPE 113
>gi|24308229 protein kinase C and casein kinase substrate in neurons
1 [Homo sapiens]
Length = 444
Score = 43.1 bits (100), Expect = 9e-04
Identities = 42/159 (26%), Positives = 68/159 (42%), Gaps = 18/159 (11%)
Query: 399 WMRPRSEWPREPQVPLYVPKFHSGWEPPVDVL----QEAPWEVEGLA----SAPIEEVSP 450
W R S P +P+ P+F W P + ++ P + EG+A + +E S
Sbjct: 286 WFRSTSG----PGMPMNWPQFEE-WNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQ 340
Query: 451 VS-RQSIRNSQKHSPTSEPTPPGDALPPVSSPHTHRGYQPTPAMAKYVKI--LYDFTARN 507
R S+ + + P + ++ P T+ G P +K V++ LYD+ +
Sbjct: 341 AGDRGSVSSYDRGQPYATEWSDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQE 400
Query: 508 ANELSVLKDEVLEVL--EDGRQWWKLRSRSGQAGYVPCN 544
+ELS + L L ED + W + R SGQ G P N
Sbjct: 401 QDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPAN 439
>gi|187155251 hypothetical protein LOC79078 [Homo sapiens]
Length = 199
Score = 43.1 bits (100), Expect = 9e-04
Identities = 35/108 (32%), Positives = 58/108 (53%), Gaps = 8/108 (7%)
Query: 468 PTPPGDALPPVSSPHTHRGYQPTP--AMAKYVKILYDFTARNA-NELSVLKDEVLEVLED 524
PTP G AL VS HTHR P A+A+ V+ +F NA N+L+V+ +++ + E
Sbjct: 34 PTPGGLAL--VSPYHTHRAGDPLDLVALAEQVQKADEFIRANATNKLTVIAEQIQHLQEQ 91
Query: 525 GRQWWKLRSRSGQAGYVPCNILGEARPEDAGAPFE-QAGQKYWGPASP 571
R+ + R +V CNI+ +P + ++ ++GQ+Y+ SP
Sbjct: 92 ARKVLEDAHRDANLHHVACNIV--KKPGNIYYLYKRESGQQYFSIISP 137
>gi|41327712 v-crk sarcoma virus CT10 oncogene homolog isoform a
[Homo sapiens]
Length = 304
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 475 LPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLE-DGRQWWKLRS 533
+ PVS G A+YV+ L+DF + +L K ++L + + QWW
Sbjct: 115 IEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
Query: 534 RSGQAGYVPCNILGEARPEDA 554
G+ G +P + + RP A
Sbjct: 175 SEGKRGMIPVPYVEKYRPASA 195
>gi|41327710 v-crk sarcoma virus CT10 oncogene homolog isoform b
[Homo sapiens]
Length = 204
Score = 42.4 bits (98), Expect = 0.002
Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 475 LPPVSSPHTHRGYQPTPAMAKYVKILYDFTARNANELSVLKDEVLEVLE-DGRQWWKLRS 533
+ PVS G A+YV+ L+DF + +L K ++L + + QWW
Sbjct: 115 IEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAED 174
Query: 534 RSGQAGYVPCNILGEARPEDA 554
G+ G +P + + RP A
Sbjct: 175 SEGKRGMIPVPYVEKYRPASA 195
>gi|63055059 SH3 and PX domains 2B [Homo sapiens]
Length = 911
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/76 (30%), Positives = 45/76 (59%), Gaps = 10/76 (13%)
Query: 499 ILYDFTARNANELSVLKDEVLEVLEDGRQ-WWKLRSRSGQAGYVPCNILGEARPEDAGAP 557
++Y +TAR+ +E+++ + V+EV++ + WWK+R + G+ G+ P + L +++G P
Sbjct: 228 VIYPYTARDQDEMNLERGAVVEVIQKNLEGWWKIRYQ-GKEGWAPASYL----KKNSGEP 282
Query: 558 FEQAGQKYWGPASPTH 573
GP SP+H
Sbjct: 283 LPPKP----GPGSPSH 294
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 483 THRGYQP--TPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRS-RSGQAG 539
T+ G P +P V L+ + + +L K E L +LE +WWK +S +GQ G
Sbjct: 50 TYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEG 109
Query: 540 YVPCNILGEA 549
++P N + +A
Sbjct: 110 FIPFNFVAKA 119
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 483 THRGYQP--TPAMAKYVKILYDFTARNANELSVLKDEVLEVLEDGRQWWKLRS-RSGQAG 539
T+ G P +P V L+ + + +L K E L +LE +WWK +S +GQ G
Sbjct: 50 TYEGSNPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEG 109
Query: 540 YVPCNILGEA 549
++P N + +A
Sbjct: 110 FIPFNFVAKA 119
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 41.6 bits (96), Expect = 0.003
Identities = 29/104 (27%), Positives = 44/104 (42%), Gaps = 11/104 (10%)
Query: 452 SRQSIRNSQKHSPTSEP-----TPPGDALPPVSSPHTHRGYQPTPA-----MAKYVKILY 501
S Q R ++K +P E + ALPP R P P + V +Y
Sbjct: 129 SYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMY 188
Query: 502 DFTARNANELSVLKDEVLEVLEDGR-QWWKLRSRSGQAGYVPCN 544
DF A ++L + + + +LE WW+ R + G GY+P N
Sbjct: 189 DFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSN 232
>gi|199559490 Abelson helper integration site 1 isoform a [Homo
sapiens]
Length = 1196
Score = 41.6 bits (96), Expect = 0.003
Identities = 19/52 (36%), Positives = 29/52 (55%), Gaps = 1/52 (1%)
Query: 494 AKYVKILYDFTARNANELSVLKDEVLEV-LEDGRQWWKLRSRSGQAGYVPCN 544
A V LYD+TA ++EL++ + +++ V +D WW GQ GY P N
Sbjct: 1053 APTVVALYDYTANRSDELTIHRGDIIRVFFKDNEDWWYGSIGKGQEGYFPAN 1104
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,144,179
Number of Sequences: 37866
Number of extensions: 1619695
Number of successful extensions: 6733
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 155
Number of HSP's that attempted gapping in prelim test: 6410
Number of HSP's gapped (non-prelim): 435
length of query: 715
length of database: 18,247,518
effective HSP length: 109
effective length of query: 606
effective length of database: 14,120,124
effective search space: 8556795144
effective search space used: 8556795144
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.