Guide to the Human Genome
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Search of human proteins with 209870079

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
         (447 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209870079 caspase 5 isoform f precursor [Homo sapiens]             899   0.0  
gi|209870069 caspase 5 isoform a precursor [Homo sapiens]             872   0.0  
gi|209870071 caspase 5 isoform b precursor [Homo sapiens]             757   0.0  
gi|209870073 caspase 5 isoform c [Homo sapiens]                       591   e-169
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]           555   e-158
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]          494   e-140
gi|209870075 caspase 5 isoform d [Homo sapiens]                       441   e-124
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]            341   9e-94
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]          333   2e-91
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]          323   3e-88
gi|15431332 caspase 1 isoform delta [Homo sapiens]                    258   8e-69
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]           98   2e-20
gi|15431334 caspase 1 isoform epsilon [Homo sapiens]                   93   6e-19
gi|14790115 caspase 3 preproprotein [Homo sapiens]                     83   6e-16
gi|14790119 caspase 3 preproprotein [Homo sapiens]                     83   6e-16
gi|6912286 caspase 14 precursor [Homo sapiens]                         81   2e-15
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]          79   6e-15
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]          77   3e-14
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]          75   9e-14
gi|15718698 caspase 7 isoform delta [Homo sapiens]                     75   2e-13
gi|15718700 caspase 7 isoform alpha [Homo sapiens]                     75   2e-13
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]            75   2e-13
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]       74   4e-13
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]       65   2e-10
gi|122056476 caspase 8 isoform G precursor [Homo sapiens]              59   7e-09
gi|15718706 caspase 8 isoform B precursor [Homo sapiens]               59   7e-09
gi|122056474 caspase 8 isoform C precursor [Homo sapiens]              56   6e-08
gi|15718708 caspase 8 isoform C precursor [Homo sapiens]               56   6e-08
gi|15718704 caspase 8 isoform A precursor [Homo sapiens]               56   6e-08
gi|14916485 caspase 6 isoform beta [Homo sapiens]                      54   2e-07

>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
          Length = 447

 Score =  899 bits (2324), Expect = 0.0
 Identities = 447/447 (100%), Positives = 447/447 (100%)

Query: 1   MAAVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQT 60
           MAAVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQT
Sbjct: 1   MAAVPRVEGVFIFLIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQT 60

Query: 61  LVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTK 120
           LVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTK
Sbjct: 61  LVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTK 120

Query: 121 IEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCP 180
           IEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCP
Sbjct: 121 IEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCP 180

Query: 181 REEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLG 240
           REEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLG
Sbjct: 181 REEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLG 240

Query: 241 YTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLL 300
           YTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLL
Sbjct: 241 YTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLL 300

Query: 301 YDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADS 360
           YDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADS
Sbjct: 301 YDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADS 360

Query: 361 VCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF 420
           VCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF
Sbjct: 361 VCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF 420

Query: 421 EVPQAKAQMPTIERATLTRDFYLFPGN 447
           EVPQAKAQMPTIERATLTRDFYLFPGN
Sbjct: 421 EVPQAKAQMPTIERATLTRDFYLFPGN 447


>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
          Length = 434

 Score =  872 bits (2253), Expect = 0.0
 Identities = 432/434 (99%), Positives = 433/434 (99%)

Query: 14  LIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK 73
           + EDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
Sbjct: 1   MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK 60

Query: 74  KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 133
           KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
Sbjct: 61  KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 120

Query: 134 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 193
           KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
Sbjct: 121 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 180

Query: 194 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 253
           EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
Sbjct: 181 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 240

Query: 254 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 313
           MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
Sbjct: 241 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 300

Query: 314 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 373
           LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
Sbjct: 301 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 360

Query: 374 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 433
           CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
Sbjct: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 420

Query: 434 RATLTRDFYLFPGN 447
           RATLTRDFYLFPGN
Sbjct: 421 RATLTRDFYLFPGN 434


>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
          Length = 376

 Score =  757 bits (1955), Expect = 0.0
 Identities = 373/374 (99%), Positives = 374/374 (100%)

Query: 74  KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 133
           +DNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
Sbjct: 3   EDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 62

Query: 134 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 193
           KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
Sbjct: 63  KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 122

Query: 194 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 253
           EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
Sbjct: 123 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 182

Query: 254 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 313
           MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
Sbjct: 183 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 242

Query: 314 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 373
           LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
Sbjct: 243 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 302

Query: 374 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 433
           CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
Sbjct: 303 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 362

Query: 434 RATLTRDFYLFPGN 447
           RATLTRDFYLFPGN
Sbjct: 363 RATLTRDFYLFPGN 376


>gi|209870073 caspase 5 isoform c [Homo sapiens]
          Length = 292

 Score =  591 bits (1523), Expect = e-169
 Identities = 289/289 (100%), Positives = 289/289 (100%)

Query: 159 LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH 218
           LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH
Sbjct: 4   LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH 63

Query: 219 LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM 278
           LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM
Sbjct: 64  LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM 123

Query: 279 SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV 338
           SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV
Sbjct: 124 SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV 183

Query: 339 RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT 398
           RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT
Sbjct: 184 RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT 243

Query: 399 CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 447
           CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
Sbjct: 244 CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 292


>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
          Length = 377

 Score =  555 bits (1430), Expect = e-158
 Identities = 276/373 (73%), Positives = 309/373 (82%), Gaps = 1/373 (0%)

Query: 76  NHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR-K 134
           NH+KK +K+LE LGKD L GV + L + +VL  KEEEKKKYYD K EDK  ++ DS++ K
Sbjct: 5   NHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEK 64

Query: 135 NRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDE 194
            R+A QM  QT  N+DQ   + K    +EAGPPES EST+ LKLCP EEFLRLCK+  +E
Sbjct: 65  QRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEE 124

Query: 195 IYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 254
           IYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V  E+NLTARDM
Sbjct: 125 IYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDM 184

Query: 255 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 314
           ES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQIFNNRNCL
Sbjct: 185 ESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCL 244

Query: 315 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFC 374
           SLKDKPKVIIVQACRG   GELWVRDSPASL + SSQSSENLE D+V K H EKDFIAFC
Sbjct: 245 SLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFC 304

Query: 375 SSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER 434
           SSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AKAQMPTIER
Sbjct: 305 SSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIER 364

Query: 435 ATLTRDFYLFPGN 447
            ++TR FYLFPGN
Sbjct: 365 LSMTRYFYLFPGN 377


>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
          Length = 321

 Score =  494 bits (1272), Expect = e-140
 Identities = 245/321 (76%), Positives = 271/321 (84%), Gaps = 1/321 (0%)

Query: 128 LVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLR 186
           + DS++ K R+A QM  QT  N+DQ   + K    +EAGPPES EST+ LKLCP EEFLR
Sbjct: 1   MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60

Query: 187 LCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDE 246
           LCK+  +EIYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V  E
Sbjct: 61  LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120

Query: 247 KNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQ 306
           +NLTARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQ
Sbjct: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180

Query: 307 IFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHE 366
           IFNNRNCLSLKDKPKVIIVQACRG   GELWVRDSPASL + SSQSSENLE D+V K H 
Sbjct: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240

Query: 367 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 426
           EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AK
Sbjct: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300

Query: 427 AQMPTIERATLTRDFYLFPGN 447
           AQMPTIER ++TR FYLFPGN
Sbjct: 301 AQMPTIERLSMTRYFYLFPGN 321


>gi|209870075 caspase 5 isoform d [Homo sapiens]
          Length = 216

 Score =  441 bits (1134), Expect = e-124
 Identities = 216/216 (100%), Positives = 216/216 (100%)

Query: 232 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 291
           MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH
Sbjct: 1   MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 60

Query: 292 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 351
           KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ
Sbjct: 61  KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 120

Query: 352 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 411
           SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME
Sbjct: 121 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 180

Query: 412 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 447
           IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
Sbjct: 181 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 216


>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
          Length = 383

 Score =  341 bits (874), Expect = 9e-94
 Identities = 185/377 (49%), Positives = 236/377 (62%), Gaps = 7/377 (1%)

Query: 78  KKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS-LRKNR 136
           K+K    +  +G+  ++G+ + L +  VL  +E EK K  +  + DK   L+DS + K  
Sbjct: 7   KEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGA 66

Query: 137 VAHQMFTQTLLNMDQKITSVKPL------LQIEAGPPESAESTNILKLCPREEFLRLCKK 190
            A Q+    +   D  +     L      +Q     P S+ S   +KLC  EE  R+ K+
Sbjct: 67  QACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQ 126

Query: 191 NHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLT 250
              EIYPI  +  R RLALIICN +FD +P R GA  DI GM  LLQ LGY+V  +KNLT
Sbjct: 127 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186

Query: 251 ARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNN 310
           A DM + L AFA RPEHK+SDSTFLV MSHGI EGICG  H ++ PD+L  + IF + N 
Sbjct: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246

Query: 311 RNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF 370
           +NC SLKDKPKVII+QACRG+  G +W +DS      +S  ++E  E D++ K H EKDF
Sbjct: 247 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 306

Query: 371 IAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMP 430
           IAFCSSTP NVSWR  T GS+FI  LI   Q+Y+C C + EIFRKV+ SFE P  +AQMP
Sbjct: 307 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMP 366

Query: 431 TIERATLTRDFYLFPGN 447
           T ER TLTR FYLFPG+
Sbjct: 367 TTERVTLTRCFYLFPGH 383


>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
          Length = 404

 Score =  333 bits (854), Expect = 2e-91
 Identities = 190/398 (47%), Positives = 242/398 (60%), Gaps = 28/398 (7%)

Query: 78  KKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS-LRKNR 136
           K+K    +  +G+  ++G+ + L +  VL  +E EK K  +  + DK   L+DS + K  
Sbjct: 7   KEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGA 66

Query: 137 VAHQMFTQTL----------------------LNMD--QKITSVKPLLQ-IEAGP--PES 169
            A Q+    +                      LNM   Q + S  P  Q ++  P  P S
Sbjct: 67  QACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTS 126

Query: 170 AESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDI 229
           + S   +KLC  EE  R+ K+   EIYPI  +  R RLALIICN +FD +P R GA  DI
Sbjct: 127 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDI 186

Query: 230 VGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGT 289
            GM  LLQ LGY+V  +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG 
Sbjct: 187 TGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGK 246

Query: 290 AHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALIS 349
            H ++ PD+L  + IF + N +NC SLKDKPKVII+QACRG+  G +W +DS      +S
Sbjct: 247 KHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLS 306

Query: 350 SQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHL 409
             ++E  E D++ K H EKDFIAFCSSTP NVSWR  T GS+FI  LI   Q+Y+C C +
Sbjct: 307 LPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV 366

Query: 410 MEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 447
            EIFRKV+ SFE P  +AQMPT ER TLTR FYLFPG+
Sbjct: 367 EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404


>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
          Length = 311

 Score =  323 bits (827), Expect = 3e-88
 Identities = 163/281 (58%), Positives = 196/281 (69%)

Query: 167 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 226
           P S+ S   +KLC  EE  R+ K+   EIYPI  +  R RLALIICN +FD +P R GA 
Sbjct: 31  PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90

Query: 227 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 286
            DI GM  LLQ LGY+V  +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91  VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150

Query: 287 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 346
           CG  H ++ PD+L  + IF + N +NC SLKDKPKVII+QACRG+  G +W +DS     
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210

Query: 347 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 406
            +S  ++E  E D++ K H EKDFIAFCSSTP NVSWR  T GS+FI  LI   Q+Y+C 
Sbjct: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270

Query: 407 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 447
           C + EIFRKV+ SFE P  +AQMPT ER TLTR FYLFPG+
Sbjct: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311


>gi|15431332 caspase 1 isoform delta [Homo sapiens]
          Length = 263

 Score =  258 bits (659), Expect = 8e-69
 Identities = 141/281 (50%), Positives = 167/281 (59%), Gaps = 48/281 (17%)

Query: 167 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 226
           P S+ S   +KLC  EE  R+ K+   EIYPI  +  R RLALIICN +FD +P R GA 
Sbjct: 31  PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90

Query: 227 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 286
            DI GM  LLQ LGY+V  +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91  VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150

Query: 287 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 346
           CG  H ++ PD+L  + IF + N +NC SLKDKPKVII+QACRG+               
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGD--------------- 195

Query: 347 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 406
                                            NVSWR  T GS+FI  LI   Q+Y+C 
Sbjct: 196 ---------------------------------NVSWRHPTMGSVFIGRLIEHMQEYACS 222

Query: 407 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 447
           C + EIFRKV+ SFE P  +AQMPT ER TLTR FYLFPG+
Sbjct: 223 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 263


>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
          Length = 452

 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 75/256 (29%), Positives = 118/256 (46%), Gaps = 18/256 (7%)

Query: 205 RRLALIICNTKFD---HLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAF 261
           R LAL++ N  F     L  R+G   D   +  L + LGY V    + TA++M+  L+ F
Sbjct: 199 RGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNF 258

Query: 262 AARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPK 321
           A  P H+ +DS  + L+SHG+   I G   K     +L    +FQ+F+N NC SL++KPK
Sbjct: 259 AQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQNKPK 313

Query: 322 VIIVQACRGEKHGELWVRDSPASLALI--SSQSSENLEADSVCKIHEEKDFIAFCSSTPH 379
           +  +QACRG++      +    + A      +S    E     ++    D I   +    
Sbjct: 314 MFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKG 373

Query: 380 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER----- 434
             + R+  RGS +I  L   F + +C  H+ ++  KV    +  +  A      R     
Sbjct: 374 TAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS 433

Query: 435 ---ATLTRDFYLFPGN 447
              +TL R  YLFPG+
Sbjct: 434 EYCSTLCRHLYLFPGH 449


>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
          Length = 88

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 47/85 (55%), Positives = 57/85 (67%)

Query: 363 KIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEV 422
           K+ +EK  +   S    NVSWR  T GS+FI  LI   Q+Y+C C + EIFRKV+ SFE 
Sbjct: 4   KVLKEKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQ 63

Query: 423 PQAKAQMPTIERATLTRDFYLFPGN 447
           P  +AQMPT ER TLTR FYLFPG+
Sbjct: 64  PDGRAQMPTTERVTLTRCFYLFPGH 88


>gi|14790115 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)

Query: 207 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 263
           L +II N  F     + +R+G   D   ++   + L Y V ++ +LT  ++  ++R   +
Sbjct: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104

Query: 264 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 320
           + +H    S   VL+SHG   I+ G  G    KK         I   F    C SL  KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155

Query: 321 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 379
           K+ I+QACRG +                  ++   ++ D  C KI  E DF+   S+ P 
Sbjct: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202

Query: 380 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 429
             SWR+   GS FI  L    ++Y+     M I     RKV   FE         AK Q+
Sbjct: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262

Query: 430 PTIERATLTRDFYLF 444
           P I  + LT++ Y +
Sbjct: 263 PCIV-SMLTKELYFY 276


>gi|14790119 caspase 3 preproprotein [Homo sapiens]
          Length = 277

 Score = 82.8 bits (203), Expect = 6e-16
 Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)

Query: 207 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 263
           L +II N  F     + +R+G   D   ++   + L Y V ++ +LT  ++  ++R   +
Sbjct: 46  LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104

Query: 264 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 320
           + +H    S   VL+SHG   I+ G  G    KK         I   F    C SL  KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155

Query: 321 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 379
           K+ I+QACRG +                  ++   ++ D  C KI  E DF+   S+ P 
Sbjct: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202

Query: 380 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 429
             SWR+   GS FI  L    ++Y+     M I     RKV   FE         AK Q+
Sbjct: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262

Query: 430 PTIERATLTRDFYLF 444
           P I  + LT++ Y +
Sbjct: 263 PCIV-SMLTKELYFY 276


>gi|6912286 caspase 14 precursor [Homo sapiens]
          Length = 242

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 69/245 (28%), Positives = 119/245 (48%), Gaps = 28/245 (11%)

Query: 206 RLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 265
           RLALI+C TK     AR G+  D+  ++ + + L +    +++ TA   +  L  F    
Sbjct: 18  RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72

Query: 266 EHKSS--DSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 323
           + +       F+VLM+HG  EG      K +  +++  + +F+  NN+NC +L+ KPKV 
Sbjct: 73  DSREDPVSCAFVVLMAHG-REGFL----KGEDGEMVKLENLFEALNNKNCQALRAKPKVY 127

Query: 324 IVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSW 383
           I+QACRGE+      RD   +   +       +  DS   I    D +   S+    +++
Sbjct: 128 IIQACRGEQ------RDPGET---VGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178

Query: 384 RDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFEVPQAKAQMPTIE-RATLT 438
           R   +GS FI  L+  F K     H++E+     R++ ++  V + KA+    E ++TL 
Sbjct: 179 RHDQKGSCFIQTLVDVFTKRK--GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLR 236

Query: 439 RDFYL 443
           +  YL
Sbjct: 237 KRLYL 241


>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
          Length = 479

 Score = 79.3 bits (194), Expect = 6e-15
 Identities = 80/290 (27%), Positives = 124/290 (42%), Gaps = 32/290 (11%)

Query: 120 KIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEA----GPPESAESTNI 175
           KI++  L  ++ L K  V   +        ++ I  V P +  EA    G  E    T++
Sbjct: 161 KIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDV 220

Query: 176 ---LKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGM 232
              L+  PR    R+  +NH            R L +I+ N  F  L  R G H D   +
Sbjct: 221 KTFLEALPRAAVYRM-NRNH------------RGLCVIVNNHSFTSLKDRQGTHKDAEIL 267

Query: 233 KRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHK 292
             + Q LG+TV    N+T  +ME VL+     P H   D     +++HG      G  + 
Sbjct: 268 SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYS 323

Query: 293 KKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQS 352
             +  + + + I   F    C  L +KPK+  +QAC+GE   E+    S  + AL   Q+
Sbjct: 324 SDEALIPIRE-IMSHFTALQCPRLAEKPKLFFIQACQGE---EIQPSVSIEADALNPEQA 379

Query: 353 SENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQK 402
             +L+ DS   I  E DF+   ++ P  VS+R    GS +I  L    +K
Sbjct: 380 PTSLQ-DS---IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 425


>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
          Length = 521

 Score = 77.0 bits (188), Expect = 3e-14
 Identities = 64/223 (28%), Positives = 100/223 (44%), Gaps = 21/223 (9%)

Query: 199 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 258
           +   + R L +I+ N  F  L  R G H D   +  + Q LG+TV    N+T  +ME VL
Sbjct: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336

Query: 259 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 318
           +     P H   D     +++HG      G  +   +  + + + I   F    C  L +
Sbjct: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391

Query: 319 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 378
           KPK+  +QAC+GE   E+    S  + AL   Q+  +L+ DS   I  E DF+   ++ P
Sbjct: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444

Query: 379 HNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFE 421
             VS+R    GS +I  L         C HL ++  ++ K  E
Sbjct: 445 GYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478


>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
          Length = 522

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 12/204 (5%)

Query: 199 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 258
           +   + R L +I+ N  F  L  R G H D   +  + Q LG+TV    N+T  +ME VL
Sbjct: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336

Query: 259 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 318
           +     P H   D     +++HG      G  +   +  + + + I   F    C  L +
Sbjct: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391

Query: 319 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 378
           KPK+  +QAC+GE   E+    S  + AL   Q+  +L+ DS   I  E DF+   ++ P
Sbjct: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444

Query: 379 HNVSWRDRTRGSIFITELITCFQK 402
             VS+R    GS +I  L    +K
Sbjct: 445 GYVSFRHVEEGSWYIQSLCNHLKK 468


>gi|15718698 caspase 7 isoform delta [Homo sapiens]
          Length = 336

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)

Query: 162 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 219
           ++A P  S+   ++     +   +R  K   D +  Y      ++    +II N  FD +
Sbjct: 55  VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 114

Query: 220 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 276
                RNG   D   + +  + LG+ V+   + +   M+ +L+  A+  +H ++     +
Sbjct: 115 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 173

Query: 277 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 336
           L+SHG    I G      K  V     +   F    C +L +KPK+  +QACRG +  + 
Sbjct: 174 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 227

Query: 337 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
              DS             + +A+   KI  E DF+   S+ P   SWR   RGS F+  L
Sbjct: 228 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 278

Query: 397 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 442
            +  +++     +M+I  +V     + FE          K Q+P +  + LT++ Y
Sbjct: 279 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 333


>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
          Length = 303

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)

Query: 162 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 219
           ++A P  S+   ++     +   +R  K   D +  Y      ++    +II N  FD +
Sbjct: 22  VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81

Query: 220 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 276
                RNG   D   + +  + LG+ V+   + +   M+ +L+  A+  +H ++     +
Sbjct: 82  TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140

Query: 277 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 336
           L+SHG    I G      K  V     +   F    C +L +KPK+  +QACRG +  + 
Sbjct: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194

Query: 337 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
              DS             + +A+   KI  E DF+   S+ P   SWR   RGS F+  L
Sbjct: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245

Query: 397 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 442
            +  +++     +M+I  +V     + FE          K Q+P +  + LT++ Y
Sbjct: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300


>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
          Length = 303

 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)

Query: 162 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 219
           ++A P  S+   ++     +   +R  K   D +  Y      ++    +II N  FD +
Sbjct: 22  VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81

Query: 220 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 276
                RNG   D   + +  + LG+ V+   + +   M+ +L+  A+  +H ++     +
Sbjct: 82  TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140

Query: 277 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 336
           L+SHG    I G      K  V     +   F    C +L +KPK+  +QACRG +  + 
Sbjct: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194

Query: 337 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
              DS             + +A+   KI  E DF+   S+ P   SWR   RGS F+  L
Sbjct: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245

Query: 397 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 442
            +  +++     +M+I  +V     + FE          K Q+P +  + LT++ Y
Sbjct: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300


>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
          Length = 416

 Score = 73.6 bits (179), Expect = 4e-13
 Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 28/244 (11%)

Query: 209 LIICNTKF---DHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 265
           LII N  F     L  R G++ D   ++R    L + V  + +LTA+ M   L   A + 
Sbjct: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222

Query: 266 EHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV-------LLYDTIFQIFNNRNCLSLKD 318
           +H + D   +V++SHG     C  +H +    V       +  + I  IFN  +C SL  
Sbjct: 223 DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277

Query: 319 KPKVIIVQACRGEK--HGELWVRDSPASLALISSQSSENL----------EADSVCKIHE 366
           KPK+  +QAC GE+  HG      SP   +  S+   +            + D++  +  
Sbjct: 278 KPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPT 337

Query: 367 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 426
             D     S+ P  VSWRD   GS ++  L   F++++    L  +  +V  +  V    
Sbjct: 338 PSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIY 397

Query: 427 AQMP 430
            QMP
Sbjct: 398 KQMP 401


>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
          Length = 293

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)

Query: 204 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 260
           RR +ALI  + +F     LP R G   D   + R    LG+ V    +L A ++   +  
Sbjct: 43  RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102

Query: 261 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 320
            +    H  +D    V +SHG  EG    A+  K    +   T+  +F    C SL  KP
Sbjct: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155

Query: 321 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 373
           K+ I+QACRG +H      D P   L ++ +Q+ +       ++A SV  +    DF+  
Sbjct: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209

Query: 374 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 425
            S      S R+   GS +I +L     KY       E+   V +          + P A
Sbjct: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269

Query: 426 --KAQMPTIERATLTRDFYLFP 445
             K Q+P    + LT+  + FP
Sbjct: 270 IGKKQVPCF-ASMLTKKLHFFP 290


>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
          Length = 538

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)

Query: 97  FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 149
           F +L + ++   K ++     D  IE +K +IL    +D L+  RV  Q+  ++LL +  
Sbjct: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 235

Query: 150 DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 204
           D +  S +    +E  P E +    +  +      PRE+      +  D++Y +K +   
Sbjct: 236 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 291

Query: 205 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 254
           R   LII N  F    + +P       RNG H D   +    + L + +    + T   +
Sbjct: 292 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 351

Query: 255 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 314
             +L+ +    +H + D     ++SHG    I GT  ++      +Y+   Q F    C 
Sbjct: 352 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 405

Query: 315 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 370
           SL  KPKV  +QAC+G+     + +  P       S+    LE D        I +E DF
Sbjct: 406 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 458

Query: 371 IAFCSSTPHNVSWRDRTRGSIFITEL 396
           +   ++  + VS+R+   G+ +I  L
Sbjct: 459 LLGMATVNNCVSYRNPAEGTWYIQSL 484


>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
          Length = 479

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)

Query: 97  FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 149
           F +L + ++   K ++     D  IE +K +IL    +D L+  RV  Q+  ++LL +  
Sbjct: 120 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 176

Query: 150 DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 204
           D +  S +    +E  P E +    +  +      PRE+      +  D++Y +K +   
Sbjct: 177 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 232

Query: 205 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 254
           R   LII N  F    + +P       RNG H D   +    + L + +    + T   +
Sbjct: 233 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 292

Query: 255 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 314
             +L+ +    +H + D     ++SHG    I GT  ++      +Y+   Q F    C 
Sbjct: 293 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 346

Query: 315 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 370
           SL  KPKV  +QAC+G+     + +  P       S+    LE D        I +E DF
Sbjct: 347 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 399

Query: 371 IAFCSSTPHNVSWRDRTRGSIFITEL 396
           +   ++  + VS+R+   G+ +I  L
Sbjct: 400 LLGMATVNNCVSYRNPAEGTWYIQSL 425


>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)

Query: 193 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 242
           D++Y +K +   R   LII N  F    + +P       RNG H D   +    + L + 
Sbjct: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265

Query: 243 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 302
           +    + T   +  +L+ +    +H + D     ++SHG    I GT  ++      +Y+
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320

Query: 303 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 359
              Q F    C SL  KPKV  +QAC+G+     + +  P       S+    LE D   
Sbjct: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372

Query: 360 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
                I +E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410


>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
          Length = 464

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)

Query: 193 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 242
           D++Y +K +   R   LII N  F    + +P       RNG H D   +    + L + 
Sbjct: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265

Query: 243 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 302
           +    + T   +  +L+ +    +H + D     ++SHG    I GT  ++      +Y+
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320

Query: 303 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 359
              Q F    C SL  KPKV  +QAC+G+     + +  P       S+    LE D   
Sbjct: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372

Query: 360 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
                I +E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410


>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
          Length = 496

 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)

Query: 193 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 242
           D++Y +K +   R   LII N  F    + +P       RNG H D   +    + L + 
Sbjct: 240 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297

Query: 243 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 302
           +    + T   +  +L+ +    +H + D     ++SHG    I GT  ++      +Y+
Sbjct: 298 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 352

Query: 303 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 359
              Q F    C SL  KPKV  +QAC+G+     + +  P       S+    LE D   
Sbjct: 353 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 404

Query: 360 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 396
                I +E DF+   ++  + VS+R+   G+ +I  L
Sbjct: 405 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 442


>gi|14916485 caspase 6 isoform beta [Homo sapiens]
          Length = 204

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 54/196 (27%), Positives = 82/196 (41%), Gaps = 30/196 (15%)

Query: 267 HKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQ 326
           H  +D    V +SHG  EG    A+  K    +   T+  +F    C SL  KPK+ I+Q
Sbjct: 19  HADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKPKIFIIQ 72

Query: 327 ACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAFCSSTPH 379
           ACRG +H      D P   L ++ +Q+ +       ++A SV  +    DF+   S    
Sbjct: 73  ACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 126

Query: 380 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA--KAQM 429
             S R+   GS +I +L     KY       E+   V +          + P A  K Q+
Sbjct: 127 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 186

Query: 430 PTIERATLTRDFYLFP 445
           P    + LT+  + FP
Sbjct: 187 PCF-ASMLTKKLHFFP 201


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.395 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,271,420
Number of Sequences: 37866
Number of extensions: 685796
Number of successful extensions: 1811
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1718
Number of HSP's gapped (non-prelim): 77
length of query: 447
length of database: 18,247,518
effective HSP length: 105
effective length of query: 342
effective length of database: 14,271,588
effective search space: 4880883096
effective search space used: 4880883096
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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