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Search of human proteins with 209870071
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
(376 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 762 0.0
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 757 0.0
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 757 0.0
gi|209870073 caspase 5 isoform c [Homo sapiens] 591 e-169
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 560 e-160
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 494 e-140
gi|209870075 caspase 5 isoform d [Homo sapiens] 441 e-124
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 342 2e-94
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 335 5e-92
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 323 2e-88
gi|15431332 caspase 1 isoform delta [Homo sapiens] 258 6e-69
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 98 1e-20
gi|15431334 caspase 1 isoform epsilon [Homo sapiens] 93 4e-19
gi|14790115 caspase 3 preproprotein [Homo sapiens] 83 5e-16
gi|14790119 caspase 3 preproprotein [Homo sapiens] 83 5e-16
gi|6912286 caspase 14 precursor [Homo sapiens] 81 2e-15
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 79 5e-15
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 77 3e-14
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 75 7e-14
gi|15718698 caspase 7 isoform delta [Homo sapiens] 75 1e-13
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 75 1e-13
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 75 1e-13
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 74 3e-13
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 65 1e-10
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 59 5e-09
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 59 5e-09
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 56 5e-08
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 56 5e-08
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 56 5e-08
gi|14916485 caspase 6 isoform beta [Homo sapiens] 54 2e-07
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 762 bits (1968), Expect = 0.0
Identities = 376/376 (100%), Positives = 376/376 (100%)
Query: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 60
MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS
Sbjct: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 60
Query: 61 LRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKN 120
LRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKN
Sbjct: 61 LRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKN 120
Query: 121 HDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTA 180
HDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTA
Sbjct: 121 HDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTA 180
Query: 181 RDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNR 240
RDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNR
Sbjct: 181 RDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNR 240
Query: 241 NCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFI 300
NCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFI
Sbjct: 241 NCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFI 300
Query: 301 AFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPT 360
AFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPT
Sbjct: 301 AFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPT 360
Query: 361 IERATLTRDFYLFPGN 376
IERATLTRDFYLFPGN
Sbjct: 361 IERATLTRDFYLFPGN 376
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 757 bits (1955), Expect = 0.0
Identities = 373/374 (99%), Positives = 374/374 (100%)
Query: 3 EDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 62
+DNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
Sbjct: 74 KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 133
Query: 63 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 122
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
Sbjct: 134 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 193
Query: 123 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 182
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
Sbjct: 194 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 253
Query: 183 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 242
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
Sbjct: 254 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 313
Query: 243 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 302
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
Sbjct: 314 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 373
Query: 303 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 362
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
Sbjct: 374 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 433
Query: 363 RATLTRDFYLFPGN 376
RATLTRDFYLFPGN
Sbjct: 434 RATLTRDFYLFPGN 447
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 757 bits (1955), Expect = 0.0
Identities = 373/374 (99%), Positives = 374/374 (100%)
Query: 3 EDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 62
+DNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
Sbjct: 61 KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 120
Query: 63 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 122
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
Sbjct: 121 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 180
Query: 123 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 182
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
Sbjct: 181 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 240
Query: 183 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 242
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
Sbjct: 241 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 300
Query: 243 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 302
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
Sbjct: 301 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 360
Query: 303 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 362
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
Sbjct: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 420
Query: 363 RATLTRDFYLFPGN 376
RATLTRDFYLFPGN
Sbjct: 421 RATLTRDFYLFPGN 434
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 591 bits (1523), Expect = e-169
Identities = 289/289 (100%), Positives = 289/289 (100%)
Query: 88 LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH 147
LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH
Sbjct: 4 LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH 63
Query: 148 LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM 207
LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM
Sbjct: 64 LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM 123
Query: 208 SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV 267
SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV
Sbjct: 124 SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV 183
Query: 268 RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT 327
RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT
Sbjct: 184 RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT 243
Query: 328 CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 376
CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
Sbjct: 244 CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 292
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 560 bits (1443), Expect = e-160
Identities = 279/377 (74%), Positives = 312/377 (82%), Gaps = 1/377 (0%)
Query: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 60
MAE NH+KK +K+LE LGKD L GV + L + +VL KEEEKKKYYD K EDK ++ DS
Sbjct: 1 MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADS 60
Query: 61 LR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKK 119
++ K R+A QM QT N+DQ + K +EAGPPES EST+ LKLCP EEFLRLCK+
Sbjct: 61 MQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKE 120
Query: 120 NHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLT 179
+EIYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V E+NLT
Sbjct: 121 RAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLT 180
Query: 180 ARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNN 239
ARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQIFNN
Sbjct: 181 ARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNN 240
Query: 240 RNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF 299
RNCLSLKDKPKVIIVQACRG GELWVRDSPASL + SSQSSENLE D+V K H EKDF
Sbjct: 241 RNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDF 300
Query: 300 IAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMP 359
IAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AKAQMP
Sbjct: 301 IAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMP 360
Query: 360 TIERATLTRDFYLFPGN 376
TIER ++TR FYLFPGN
Sbjct: 361 TIERLSMTRYFYLFPGN 377
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 494 bits (1272), Expect = e-140
Identities = 245/321 (76%), Positives = 271/321 (84%), Gaps = 1/321 (0%)
Query: 57 LVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLR 115
+ DS++ K R+A QM QT N+DQ + K +EAGPPES EST+ LKLCP EEFLR
Sbjct: 1 MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60
Query: 116 LCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDE 175
LCK+ +EIYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V E
Sbjct: 61 LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120
Query: 176 KNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQ 235
+NLTARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQ
Sbjct: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180
Query: 236 IFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHE 295
IFNNRNCLSLKDKPKVIIVQACRG GELWVRDSPASL + SSQSSENLE D+V K H
Sbjct: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240
Query: 296 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 355
EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AK
Sbjct: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
Query: 356 AQMPTIERATLTRDFYLFPGN 376
AQMPTIER ++TR FYLFPGN
Sbjct: 301 AQMPTIERLSMTRYFYLFPGN 321
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 441 bits (1134), Expect = e-124
Identities = 216/216 (100%), Positives = 216/216 (100%)
Query: 161 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 220
MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH
Sbjct: 1 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 60
Query: 221 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 280
KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ
Sbjct: 61 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 120
Query: 281 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 340
SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME
Sbjct: 121 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 180
Query: 341 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 376
IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
Sbjct: 181 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 216
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 342 bits (878), Expect = 2e-94
Identities = 187/383 (48%), Positives = 239/383 (62%), Gaps = 7/383 (1%)
Query: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 60
MA+ K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 -LRKNRVAHQMFTQTLLNMDQKITSVKPL------LQIEAGPPESAESTNILKLCPREEF 113
+ K A Q+ + D + L +Q P S+ S +KLC EE
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEA 120
Query: 114 LRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVV 173
R+ K+ EIYPI + R RLALIICN +FD +P R GA DI GM LLQ LGY+V
Sbjct: 121 QRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVD 180
Query: 174 DEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTI 233
+KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H ++ PD+L + I
Sbjct: 181 VKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAI 240
Query: 234 FQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKI 293
F + N +NC SLKDKPKVII+QACRG+ G +W +DS +S ++E E D++ K
Sbjct: 241 FNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKA 300
Query: 294 HEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQ 353
H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C C + EIFRKV+ SFE P
Sbjct: 301 HIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPD 360
Query: 354 AKAQMPTIERATLTRDFYLFPGN 376
+AQMPT ER TLTR FYLFPG+
Sbjct: 361 GRAQMPTTERVTLTRCFYLFPGH 383
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 335 bits (858), Expect = 5e-92
Identities = 192/404 (47%), Positives = 245/404 (60%), Gaps = 28/404 (6%)
Query: 1 MAEDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS 60
MA+ K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS
Sbjct: 1 MADKVLKEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDS 60
Query: 61 -LRKNRVAHQMFTQTL----------------------LNMD--QKITSVKPLLQ-IEAG 94
+ K A Q+ + LNM Q + S P Q ++
Sbjct: 61 VIPKGAQACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDN 120
Query: 95 P--PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARN 152
P P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R
Sbjct: 121 PAMPTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRT 180
Query: 153 GAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGIL 212
GA DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI
Sbjct: 181 GAEVDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIR 240
Query: 213 EGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPA 272
EGICG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 241 EGICGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVG 300
Query: 273 SLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKY 332
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y
Sbjct: 301 VSGNLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEY 360
Query: 333 SCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 376
+C C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 361 ACSCDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 323 bits (827), Expect = 2e-88
Identities = 163/281 (58%), Positives = 196/281 (69%)
Query: 96 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 155
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
Query: 156 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 215
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
Query: 216 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 275
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
Query: 276 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 335
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C
Sbjct: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
Query: 336 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 376
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 258 bits (659), Expect = 6e-69
Identities = 141/281 (50%), Positives = 167/281 (59%), Gaps = 48/281 (17%)
Query: 96 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 155
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
Query: 156 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 215
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
Query: 216 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 275
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGD--------------- 195
Query: 276 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 335
NVSWR T GS+FI LI Q+Y+C
Sbjct: 196 ---------------------------------NVSWRHPTMGSVFIGRLIEHMQEYACS 222
Query: 336 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 376
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 223 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 263
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 97.8 bits (242), Expect = 1e-20
Identities = 75/256 (29%), Positives = 118/256 (46%), Gaps = 18/256 (7%)
Query: 134 RRLALIICNTKFD---HLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAF 190
R LAL++ N F L R+G D + L + LGY V + TA++M+ L+ F
Sbjct: 199 RGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNF 258
Query: 191 AARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPK 250
A P H+ +DS + L+SHG+ I G K +L +FQ+F+N NC SL++KPK
Sbjct: 259 AQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQNKPK 313
Query: 251 VIIVQACRGEKHGELWVRDSPASLALI--SSQSSENLEADSVCKIHEEKDFIAFCSSTPH 308
+ +QACRG++ + + A +S E ++ D I +
Sbjct: 314 MFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKG 373
Query: 309 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER----- 363
+ R+ RGS +I L F + +C H+ ++ KV + + A R
Sbjct: 374 TAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS 433
Query: 364 ---ATLTRDFYLFPGN 376
+TL R YLFPG+
Sbjct: 434 EYCSTLCRHLYLFPGH 449
>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
Length = 88
Score = 92.8 bits (229), Expect = 4e-19
Identities = 47/85 (55%), Positives = 57/85 (67%)
Query: 292 KIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEV 351
K+ +EK + S NVSWR T GS+FI LI Q+Y+C C + EIFRKV+ SFE
Sbjct: 4 KVLKEKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQ 63
Query: 352 PQAKAQMPTIERATLTRDFYLFPGN 376
P +AQMPT ER TLTR FYLFPG+
Sbjct: 64 PDGRAQMPTTERVTLTRCFYLFPGH 88
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 82.8 bits (203), Expect = 5e-16
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)
Query: 136 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 192
L +II N F + +R+G D ++ + L Y V ++ +LT ++ ++R +
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
Query: 193 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 249
+ +H S VL+SHG I+ G G KK I F C SL KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
Query: 250 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 308
K+ I+QACRG + ++ ++ D C KI E DF+ S+ P
Sbjct: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
Query: 309 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 358
SWR+ GS FI L ++Y+ M I RKV FE AK Q+
Sbjct: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
Query: 359 PTIERATLTRDFYLF 373
P I + LT++ Y +
Sbjct: 263 PCIV-SMLTKELYFY 276
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 82.8 bits (203), Expect = 5e-16
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)
Query: 136 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 192
L +II N F + +R+G D ++ + L Y V ++ +LT ++ ++R +
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
Query: 193 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 249
+ +H S VL+SHG I+ G G KK I F C SL KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
Query: 250 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 308
K+ I+QACRG + ++ ++ D C KI E DF+ S+ P
Sbjct: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
Query: 309 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 358
SWR+ GS FI L ++Y+ M I RKV FE AK Q+
Sbjct: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
Query: 359 PTIERATLTRDFYLF 373
P I + LT++ Y +
Sbjct: 263 PCIV-SMLTKELYFY 276
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 80.9 bits (198), Expect = 2e-15
Identities = 69/245 (28%), Positives = 119/245 (48%), Gaps = 28/245 (11%)
Query: 135 RLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 194
RLALI+C TK AR G+ D+ ++ + + L + +++ TA + L F
Sbjct: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
Query: 195 EHKSS--DSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 252
+ + F+VLM+HG EG K + +++ + +F+ NN+NC +L+ KPKV
Sbjct: 73 DSREDPVSCAFVVLMAHG-REGFL----KGEDGEMVKLENLFEALNNKNCQALRAKPKVY 127
Query: 253 IVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSW 312
I+QACRGE+ RD + + + DS I D + S+ +++
Sbjct: 128 IIQACRGEQ------RDPGET---VGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178
Query: 313 RDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFEVPQAKAQMPTIE-RATLT 367
R +GS FI L+ F K H++E+ R++ ++ V + KA+ E ++TL
Sbjct: 179 RHDQKGSCFIQTLVDVFTKRK--GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLR 236
Query: 368 RDFYL 372
+ YL
Sbjct: 237 KRLYL 241
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 79.3 bits (194), Expect = 5e-15
Identities = 80/290 (27%), Positives = 124/290 (42%), Gaps = 32/290 (11%)
Query: 49 KIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEA----GPPESAESTNI 104
KI++ L ++ L K V + ++ I V P + EA G E T++
Sbjct: 161 KIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDV 220
Query: 105 ---LKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGM 161
L+ PR R+ +NH R L +I+ N F L R G H D +
Sbjct: 221 KTFLEALPRAAVYRM-NRNH------------RGLCVIVNNHSFTSLKDRQGTHKDAEIL 267
Query: 162 KRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHK 221
+ Q LG+TV N+T +ME VL+ P H D +++HG G +
Sbjct: 268 SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYS 323
Query: 222 KKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQS 281
+ + + + I F C L +KPK+ +QAC+GE E+ S + AL Q+
Sbjct: 324 SDEALIPIRE-IMSHFTALQCPRLAEKPKLFFIQACQGE---EIQPSVSIEADALNPEQA 379
Query: 282 SENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQK 331
+L+ DS I E DF+ ++ P VS+R GS +I L +K
Sbjct: 380 PTSLQ-DS---IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 425
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 77.0 bits (188), Expect = 3e-14
Identities = 64/223 (28%), Positives = 100/223 (44%), Gaps = 21/223 (9%)
Query: 128 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 187
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336
Query: 188 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 247
+ P H D +++HG G + + + + + I F C L +
Sbjct: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391
Query: 248 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 307
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444
Query: 308 HNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFE 350
VS+R GS +I L C HL ++ ++ K E
Sbjct: 445 GYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 75.5 bits (184), Expect = 7e-14
Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 12/204 (5%)
Query: 128 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 187
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336
Query: 188 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 247
+ P H D +++HG G + + + + + I F C L +
Sbjct: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391
Query: 248 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 307
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444
Query: 308 HNVSWRDRTRGSIFITELITCFQK 331
VS+R GS +I L +K
Sbjct: 445 GYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 74.7 bits (182), Expect = 1e-13
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 91 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 148
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 55 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 114
Query: 149 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 205
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 115 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 173
Query: 206 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 265
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 174 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 227
Query: 266 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 325
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 228 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 278
Query: 326 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 371
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 279 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 333
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 74.7 bits (182), Expect = 1e-13
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 91 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 148
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 22 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
Query: 149 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 205
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 82 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
Query: 206 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 265
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
Query: 266 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 325
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
Query: 326 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 371
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 74.7 bits (182), Expect = 1e-13
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 91 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 148
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 22 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
Query: 149 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 205
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 82 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
Query: 206 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 265
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
Query: 266 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 325
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
Query: 326 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 371
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 73.6 bits (179), Expect = 3e-13
Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 28/244 (11%)
Query: 138 LIICNTKF---DHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 194
LII N F L R G++ D ++R L + V + +LTA+ M L A +
Sbjct: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
Query: 195 EHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV-------LLYDTIFQIFNNRNCLSLKD 247
+H + D +V++SHG C +H + V + + I IFN +C SL
Sbjct: 223 DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
Query: 248 KPKVIIVQACRGEK--HGELWVRDSPASLALISSQSSENL----------EADSVCKIHE 295
KPK+ +QAC GE+ HG SP + S+ + + D++ +
Sbjct: 278 KPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPT 337
Query: 296 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 355
D S+ P VSWRD GS ++ L F++++ L + +V + V
Sbjct: 338 PSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIY 397
Query: 356 AQMP 359
QMP
Sbjct: 398 KQMP 401
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 64.7 bits (156), Expect = 1e-10
Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)
Query: 133 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 189
RR +ALI + +F LP R G D + R LG+ V +L A ++ +
Sbjct: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
Query: 190 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 249
+ H +D V +SHG EG A+ K + T+ +F C SL KP
Sbjct: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
Query: 250 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 302
K+ I+QACRG +H D P L ++ +Q+ + ++A SV + DF+
Sbjct: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
Query: 303 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 354
S S R+ GS +I +L KY E+ V + + P A
Sbjct: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
Query: 355 --KAQMPTIERATLTRDFYLFP 374
K Q+P + LT+ + FP
Sbjct: 270 IGKKQVPCF-ASMLTKKLHFFP 290
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 59.3 bits (142), Expect = 5e-09
Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)
Query: 26 FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 78
F +L + ++ K ++ D IE +K +IL +D L+ RV Q+ ++LL +
Sbjct: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 235
Query: 79 DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 133
D + S + +E P E + + + PRE+ + D++Y +K +
Sbjct: 236 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 291
Query: 134 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 183
R LII N F + +P RNG H D + + L + + + T +
Sbjct: 292 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 351
Query: 184 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 243
+L+ + +H + D ++SHG I GT ++ +Y+ Q F C
Sbjct: 352 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 405
Query: 244 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 299
SL KPKV +QAC+G+ + + P S+ LE D I +E DF
Sbjct: 406 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 458
Query: 300 IAFCSSTPHNVSWRDRTRGSIFITEL 325
+ ++ + VS+R+ G+ +I L
Sbjct: 459 LLGMATVNNCVSYRNPAEGTWYIQSL 484
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 59.3 bits (142), Expect = 5e-09
Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)
Query: 26 FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 78
F +L + ++ K ++ D IE +K +IL +D L+ RV Q+ ++LL +
Sbjct: 120 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 176
Query: 79 DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 133
D + S + +E P E + + + PRE+ + D++Y +K +
Sbjct: 177 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 232
Query: 134 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 183
R LII N F + +P RNG H D + + L + + + T +
Sbjct: 233 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 292
Query: 184 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 243
+L+ + +H + D ++SHG I GT ++ +Y+ Q F C
Sbjct: 293 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 346
Query: 244 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 299
SL KPKV +QAC+G+ + + P S+ LE D I +E DF
Sbjct: 347 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 399
Query: 300 IAFCSSTPHNVSWRDRTRGSIFITEL 325
+ ++ + VS+R+ G+ +I L
Sbjct: 400 LLGMATVNNCVSYRNPAEGTWYIQSL 425
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 56.2 bits (134), Expect = 5e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 122 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 171
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
Query: 172 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 231
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320
Query: 232 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 288
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372
Query: 289 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 325
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 56.2 bits (134), Expect = 5e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 122 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 171
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
Query: 172 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 231
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320
Query: 232 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 288
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372
Query: 289 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 325
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 56.2 bits (134), Expect = 5e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 122 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 171
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 240 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297
Query: 172 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 231
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 298 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 352
Query: 232 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 288
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 353 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 404
Query: 289 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 325
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 405 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 442
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 54.3 bits (129), Expect = 2e-07
Identities = 54/196 (27%), Positives = 82/196 (41%), Gaps = 30/196 (15%)
Query: 196 HKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQ 255
H +D V +SHG EG A+ K + T+ +F C SL KPK+ I+Q
Sbjct: 19 HADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKPKIFIIQ 72
Query: 256 ACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAFCSSTPH 308
ACRG +H D P L ++ +Q+ + ++A SV + DF+ S
Sbjct: 73 ACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 126
Query: 309 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA--KAQM 358
S R+ GS +I +L KY E+ V + + P A K Q+
Sbjct: 127 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 186
Query: 359 PTIERATLTRDFYLFP 374
P + LT+ + FP
Sbjct: 187 PCF-ASMLTKKLHFFP 201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.135 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,016,652
Number of Sequences: 37866
Number of extensions: 586922
Number of successful extensions: 1479
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 11
Number of HSP's that attempted gapping in prelim test: 1386
Number of HSP's gapped (non-prelim): 74
length of query: 376
length of database: 18,247,518
effective HSP length: 104
effective length of query: 272
effective length of database: 14,309,454
effective search space: 3892171488
effective search space used: 3892171488
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.