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Search of human proteins with 209870069
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
(434 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209870069 caspase 5 isoform a precursor [Homo sapiens] 875 0.0
gi|209870079 caspase 5 isoform f precursor [Homo sapiens] 872 0.0
gi|209870071 caspase 5 isoform b precursor [Homo sapiens] 757 0.0
gi|209870073 caspase 5 isoform c [Homo sapiens] 591 e-169
gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens] 555 e-158
gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens] 494 e-140
gi|209870075 caspase 5 isoform d [Homo sapiens] 441 e-124
gi|4502573 caspase 1 isoform beta precursor [Homo sapiens] 341 9e-94
gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens] 333 2e-91
gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens] 323 2e-88
gi|15431332 caspase 1 isoform delta [Homo sapiens] 258 7e-69
gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens] 98 2e-20
gi|15431334 caspase 1 isoform epsilon [Homo sapiens] 93 5e-19
gi|14790115 caspase 3 preproprotein [Homo sapiens] 83 6e-16
gi|14790119 caspase 3 preproprotein [Homo sapiens] 83 6e-16
gi|6912286 caspase 14 precursor [Homo sapiens] 81 2e-15
gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens] 79 6e-15
gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens] 77 3e-14
gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens] 75 9e-14
gi|15718698 caspase 7 isoform delta [Homo sapiens] 75 2e-13
gi|15718700 caspase 7 isoform alpha [Homo sapiens] 75 2e-13
gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens] 75 2e-13
gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens] 74 3e-13
gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens] 65 2e-10
gi|122056476 caspase 8 isoform G precursor [Homo sapiens] 59 7e-09
gi|15718706 caspase 8 isoform B precursor [Homo sapiens] 59 7e-09
gi|122056474 caspase 8 isoform C precursor [Homo sapiens] 56 6e-08
gi|15718708 caspase 8 isoform C precursor [Homo sapiens] 56 6e-08
gi|15718704 caspase 8 isoform A precursor [Homo sapiens] 56 6e-08
gi|14916485 caspase 6 isoform beta [Homo sapiens] 54 2e-07
>gi|209870069 caspase 5 isoform a precursor [Homo sapiens]
Length = 434
Score = 875 bits (2261), Expect = 0.0
Identities = 434/434 (100%), Positives = 434/434 (100%)
Query: 1 MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK 60
MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
Sbjct: 1 MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK 60
Query: 61 KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 120
KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
Sbjct: 61 KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 120
Query: 121 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 180
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
Sbjct: 121 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 180
Query: 181 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 240
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
Sbjct: 181 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 240
Query: 241 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 300
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
Sbjct: 241 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 300
Query: 301 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 360
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
Sbjct: 301 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 360
Query: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 420
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
Sbjct: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 420
Query: 421 RATLTRDFYLFPGN 434
RATLTRDFYLFPGN
Sbjct: 421 RATLTRDFYLFPGN 434
>gi|209870079 caspase 5 isoform f precursor [Homo sapiens]
Length = 447
Score = 872 bits (2253), Expect = 0.0
Identities = 432/434 (99%), Positives = 433/434 (99%)
Query: 1 MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK 60
+ EDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK
Sbjct: 14 LIEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVK 73
Query: 61 KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 120
KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
Sbjct: 74 KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 133
Query: 121 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 180
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
Sbjct: 134 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 193
Query: 181 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 240
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
Sbjct: 194 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 253
Query: 241 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 300
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
Sbjct: 254 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 313
Query: 301 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 360
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
Sbjct: 314 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 373
Query: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 420
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
Sbjct: 374 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 433
Query: 421 RATLTRDFYLFPGN 434
RATLTRDFYLFPGN
Sbjct: 434 RATLTRDFYLFPGN 447
>gi|209870071 caspase 5 isoform b precursor [Homo sapiens]
Length = 376
Score = 757 bits (1955), Expect = 0.0
Identities = 373/374 (99%), Positives = 374/374 (100%)
Query: 61 KDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 120
+DNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR
Sbjct: 3 EDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR 62
Query: 121 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 180
KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD
Sbjct: 63 KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHD 122
Query: 181 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 240
EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD
Sbjct: 123 EIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARD 182
Query: 241 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 300
MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC
Sbjct: 183 MESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNC 242
Query: 301 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 360
LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF
Sbjct: 243 LSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAF 302
Query: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 420
CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE
Sbjct: 303 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIE 362
Query: 421 RATLTRDFYLFPGN 434
RATLTRDFYLFPGN
Sbjct: 363 RATLTRDFYLFPGN 376
>gi|209870073 caspase 5 isoform c [Homo sapiens]
Length = 292
Score = 591 bits (1523), Expect = e-169
Identities = 289/289 (100%), Positives = 289/289 (100%)
Query: 146 LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH 205
LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH
Sbjct: 4 LLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDH 63
Query: 206 LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM 265
LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM
Sbjct: 64 LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLM 123
Query: 266 SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV 325
SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV
Sbjct: 124 SHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWV 183
Query: 326 RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT 385
RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT
Sbjct: 184 RDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELIT 243
Query: 386 CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 434
CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
Sbjct: 244 CFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 292
>gi|4502577 caspase 4 isoform alpha precursor [Homo sapiens]
Length = 377
Score = 555 bits (1430), Expect = e-158
Identities = 276/373 (73%), Positives = 309/373 (82%), Gaps = 1/373 (0%)
Query: 63 NHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLR-K 121
NH+KK +K+LE LGKD L GV + L + +VL KEEEKKKYYD K EDK ++ DS++ K
Sbjct: 5 NHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEK 64
Query: 122 NRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDE 181
R+A QM QT N+DQ + K +EAGPPES EST+ LKLCP EEFLRLCK+ +E
Sbjct: 65 QRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEE 124
Query: 182 IYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 241
IYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V E+NLTARDM
Sbjct: 125 IYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDM 184
Query: 242 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 301
ES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQIFNNRNCL
Sbjct: 185 ESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCL 244
Query: 302 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFC 361
SLKDKPKVIIVQACRG GELWVRDSPASL + SSQSSENLE D+V K H EKDFIAFC
Sbjct: 245 SLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFC 304
Query: 362 SSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER 421
SSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AKAQMPTIER
Sbjct: 305 SSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIER 364
Query: 422 ATLTRDFYLFPGN 434
++TR FYLFPGN
Sbjct: 365 LSMTRYFYLFPGN 377
>gi|15451910 caspase 4 isoform gamma precursor [Homo sapiens]
Length = 321
Score = 494 bits (1272), Expect = e-140
Identities = 245/321 (76%), Positives = 271/321 (84%), Gaps = 1/321 (0%)
Query: 115 LVDSLR-KNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLR 173
+ DS++ K R+A QM QT N+DQ + K +EAGPPES EST+ LKLCP EEFLR
Sbjct: 1 MADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLR 60
Query: 174 LCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDE 233
LCK+ +EIYPIK+R +R RLALIICNT+FDHLP RNGA +DI GMK LL+GL Y+V E
Sbjct: 61 LCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVE 120
Query: 234 KNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQ 293
+NLTARDMES LRAFA RPEHKSSDSTFLVLMSHGILEGICGT H +KKPDVLLYDTIFQ
Sbjct: 121 ENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQ 180
Query: 294 IFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHE 353
IFNNRNCLSLKDKPKVIIVQACRG GELWVRDSPASL + SSQSSENLE D+V K H
Sbjct: 181 IFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHV 240
Query: 354 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 413
EKDFIAFCSSTPHNVSWRD T GSIFIT+LITCFQKYS CCHL E+FRKVQ+SFE P+AK
Sbjct: 241 EKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAK 300
Query: 414 AQMPTIERATLTRDFYLFPGN 434
AQMPTIER ++TR FYLFPGN
Sbjct: 301 AQMPTIERLSMTRYFYLFPGN 321
>gi|209870075 caspase 5 isoform d [Homo sapiens]
Length = 216
Score = 441 bits (1134), Expect = e-124
Identities = 216/216 (100%), Positives = 216/216 (100%)
Query: 219 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 278
MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH
Sbjct: 1 MKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAH 60
Query: 279 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 338
KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ
Sbjct: 61 KKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQ 120
Query: 339 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 398
SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME
Sbjct: 121 SSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLME 180
Query: 399 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 434
IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
Sbjct: 181 IFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 216
>gi|4502573 caspase 1 isoform beta precursor [Homo sapiens]
Length = 383
Score = 341 bits (874), Expect = 9e-94
Identities = 185/377 (49%), Positives = 236/377 (62%), Gaps = 7/377 (1%)
Query: 65 KKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS-LRKNR 123
K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS + K
Sbjct: 7 KEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGA 66
Query: 124 VAHQMFTQTLLNMDQKITSVKPL------LQIEAGPPESAESTNILKLCPREEFLRLCKK 177
A Q+ + D + L +Q P S+ S +KLC EE R+ K+
Sbjct: 67 QACQICITYICEEDSYLAGTLGLSAAPQAVQDNPAMPTSSGSEGNVKLCSLEEAQRIWKQ 126
Query: 178 NHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLT 237
EIYPI + R RLALIICN +FD +P R GA DI GM LLQ LGY+V +KNLT
Sbjct: 127 KSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDITGMTMLLQNLGYSVDVKKNLT 186
Query: 238 ARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNN 297
A DM + L AFA RPEHK+SDSTFLV MSHGI EGICG H ++ PD+L + IF + N
Sbjct: 187 ASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGKKHSEQVPDILQLNAIFNMLNT 246
Query: 298 RNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDF 357
+NC SLKDKPKVII+QACRG+ G +W +DS +S ++E E D++ K H EKDF
Sbjct: 247 KNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLSLPTTEEFEDDAIKKAHIEKDF 306
Query: 358 IAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMP 417
IAFCSSTP NVSWR T GS+FI LI Q+Y+C C + EIFRKV+ SFE P +AQMP
Sbjct: 307 IAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQPDGRAQMP 366
Query: 418 TIERATLTRDFYLFPGN 434
T ER TLTR FYLFPG+
Sbjct: 367 TTERVTLTRCFYLFPGH 383
>gi|15431328 caspase 1 isoform alpha precursor [Homo sapiens]
Length = 404
Score = 333 bits (854), Expect = 2e-91
Identities = 190/398 (47%), Positives = 242/398 (60%), Gaps = 28/398 (7%)
Query: 65 KKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDS-LRKNR 123
K+K + +G+ ++G+ + L + VL +E EK K + + DK L+DS + K
Sbjct: 7 KEKRKLFIRSMGEGTINGLLDELLQTRVLNKEEMEKVKRENATVMDKTRALIDSVIPKGA 66
Query: 124 VAHQMFTQTL----------------------LNMD--QKITSVKPLLQ-IEAGP--PES 156
A Q+ + LNM Q + S P Q ++ P P S
Sbjct: 67 QACQICITYICEEDSYLAGTLGLSADQTSGNYLNMQDSQGVLSSFPAPQAVQDNPAMPTS 126
Query: 157 AESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDI 216
+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA DI
Sbjct: 127 SGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAEVDI 186
Query: 217 VGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGT 276
GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGICG
Sbjct: 187 TGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGICGK 246
Query: 277 AHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALIS 336
H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS +S
Sbjct: 247 KHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSGNLS 306
Query: 337 SQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHL 396
++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C C +
Sbjct: 307 LPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACSCDV 366
Query: 397 MEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 434
EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 367 EEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 404
>gi|15431330 caspase 1 isoform gamma precursor [Homo sapiens]
Length = 311
Score = 323 bits (827), Expect = 2e-88
Identities = 163/281 (58%), Positives = 196/281 (69%)
Query: 154 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 213
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
Query: 214 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 273
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
Query: 274 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 333
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+ G +W +DS
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGDSPGVVWFKDSVGVSG 210
Query: 334 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 393
+S ++E E D++ K H EKDFIAFCSSTP NVSWR T GS+FI LI Q+Y+C
Sbjct: 211 NLSLPTTEEFEDDAIKKAHIEKDFIAFCSSTPDNVSWRHPTMGSVFIGRLIEHMQEYACS 270
Query: 394 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 434
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 271 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 311
>gi|15431332 caspase 1 isoform delta [Homo sapiens]
Length = 263
Score = 258 bits (659), Expect = 7e-69
Identities = 141/281 (50%), Positives = 167/281 (59%), Gaps = 48/281 (17%)
Query: 154 PESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAH 213
P S+ S +KLC EE R+ K+ EIYPI + R RLALIICN +FD +P R GA
Sbjct: 31 PTSSGSEGNVKLCSLEEAQRIWKQKSAEIYPIMDKSSRTRLALIICNEEFDSIPRRTGAE 90
Query: 214 YDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGI 273
DI GM LLQ LGY+V +KNLTA DM + L AFA RPEHK+SDSTFLV MSHGI EGI
Sbjct: 91 VDITGMTMLLQNLGYSVDVKKNLTASDMTTELEAFAHRPEHKTSDSTFLVFMSHGIREGI 150
Query: 274 CGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLA 333
CG H ++ PD+L + IF + N +NC SLKDKPKVII+QACRG+
Sbjct: 151 CGKKHSEQVPDILQLNAIFNMLNTKNCPSLKDKPKVIIIQACRGD--------------- 195
Query: 334 LISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCC 393
NVSWR T GS+FI LI Q+Y+C
Sbjct: 196 ---------------------------------NVSWRHPTMGSVFIGRLIEHMQEYACS 222
Query: 394 CHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN 434
C + EIFRKV+ SFE P +AQMPT ER TLTR FYLFPG+
Sbjct: 223 CDVEEIFRKVRFSFEQPDGRAQMPTTERVTLTRCFYLFPGH 263
>gi|39995059 caspase 2 isoform 1 preproprotein [Homo sapiens]
Length = 452
Score = 97.8 bits (242), Expect = 2e-20
Identities = 75/256 (29%), Positives = 118/256 (46%), Gaps = 18/256 (7%)
Query: 192 RRLALIICNTKFD---HLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAF 248
R LAL++ N F L R+G D + L + LGY V + TA++M+ L+ F
Sbjct: 199 RGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNF 258
Query: 249 AARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPK 308
A P H+ +DS + L+SHG+ I G K +L +FQ+F+N NC SL++KPK
Sbjct: 259 AQLPAHRVTDSCIVALLSHGVEGAIYGVDGK-----LLQLQEVFQLFDNANCPSLQNKPK 313
Query: 309 VIIVQACRGEKHGELWVRDSPASLALI--SSQSSENLEADSVCKIHEEKDFIAFCSSTPH 366
+ +QACRG++ + + A +S E ++ D I +
Sbjct: 314 MFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKG 373
Query: 367 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIER----- 421
+ R+ RGS +I L F + +C H+ ++ KV + + A R
Sbjct: 374 TAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMS 433
Query: 422 ---ATLTRDFYLFPGN 434
+TL R YLFPG+
Sbjct: 434 EYCSTLCRHLYLFPGH 449
>gi|15431334 caspase 1 isoform epsilon [Homo sapiens]
Length = 88
Score = 92.8 bits (229), Expect = 5e-19
Identities = 47/85 (55%), Positives = 57/85 (67%)
Query: 350 KIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEV 409
K+ +EK + S NVSWR T GS+FI LI Q+Y+C C + EIFRKV+ SFE
Sbjct: 4 KVLKEKRKLFIRSMGEDNVSWRHPTMGSVFIGRLIEHMQEYACSCDVEEIFRKVRFSFEQ 63
Query: 410 PQAKAQMPTIERATLTRDFYLFPGN 434
P +AQMPT ER TLTR FYLFPG+
Sbjct: 64 PDGRAQMPTTERVTLTRCFYLFPGH 88
>gi|14790115 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 82.8 bits (203), Expect = 6e-16
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)
Query: 194 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 250
L +II N F + +R+G D ++ + L Y V ++ +LT ++ ++R +
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
Query: 251 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 307
+ +H S VL+SHG I+ G G KK I F C SL KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
Query: 308 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 366
K+ I+QACRG + ++ ++ D C KI E DF+ S+ P
Sbjct: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
Query: 367 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 416
SWR+ GS FI L ++Y+ M I RKV FE AK Q+
Sbjct: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
Query: 417 PTIERATLTRDFYLF 431
P I + LT++ Y +
Sbjct: 263 PCIV-SMLTKELYFY 276
>gi|14790119 caspase 3 preproprotein [Homo sapiens]
Length = 277
Score = 82.8 bits (203), Expect = 6e-16
Identities = 73/255 (28%), Positives = 110/255 (43%), Gaps = 41/255 (16%)
Query: 194 LALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAA 250
L +II N F + +R+G D ++ + L Y V ++ +LT ++ ++R +
Sbjct: 46 LCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRD-VS 104
Query: 251 RPEHKSSDSTFLVLMSHG---ILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 307
+ +H S VL+SHG I+ G G KK I F C SL KP
Sbjct: 105 KEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKK---------ITNFFRGDRCRSLTGKP 155
Query: 308 KVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVC-KIHEEKDFIAFCSSTPH 366
K+ I+QACRG + ++ ++ D C KI E DF+ S+ P
Sbjct: 156 KLFIIQACRGTELD-------------CGIETDSGVDDDMACHKIPVEADFLYAYSTAPG 202
Query: 367 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFE------VPQAKAQM 416
SWR+ GS FI L ++Y+ M I RKV FE AK Q+
Sbjct: 203 YYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQI 262
Query: 417 PTIERATLTRDFYLF 431
P I + LT++ Y +
Sbjct: 263 PCIV-SMLTKELYFY 276
>gi|6912286 caspase 14 precursor [Homo sapiens]
Length = 242
Score = 80.9 bits (198), Expect = 2e-15
Identities = 69/245 (28%), Positives = 119/245 (48%), Gaps = 28/245 (11%)
Query: 193 RLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 252
RLALI+C TK AR G+ D+ ++ + + L + +++ TA + L F
Sbjct: 18 RLALILCVTK-----AREGSEEDLDALEHMFRQLRFESTMKRDPTAEQFQEELEKFQQAI 72
Query: 253 EHKSS--DSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVI 310
+ + F+VLM+HG EG K + +++ + +F+ NN+NC +L+ KPKV
Sbjct: 73 DSREDPVSCAFVVLMAHG-REGFL----KGEDGEMVKLENLFEALNNKNCQALRAKPKVY 127
Query: 311 IVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSW 370
I+QACRGE+ RD + + + DS I D + S+ +++
Sbjct: 128 IIQACRGEQ------RDPGET---VGGDEIVMVIKDSPQTIPTYTDALHVYSTVEGYIAY 178
Query: 371 RDRTRGSIFITELITCFQKYSCCCHLMEIF----RKVQKSFEVPQAKAQMPTIE-RATLT 425
R +GS FI L+ F K H++E+ R++ ++ V + KA+ E ++TL
Sbjct: 179 RHDQKGSCFIQTLVDVFTKRK--GHILELLTEVTRRMAEAELVQEGKARKTNPEIQSTLR 236
Query: 426 RDFYL 430
+ YL
Sbjct: 237 KRLYL 241
>gi|47078267 caspase 10 isoform a preproprotein [Homo sapiens]
Length = 479
Score = 79.3 bits (194), Expect = 6e-15
Identities = 80/290 (27%), Positives = 124/290 (42%), Gaps = 32/290 (11%)
Query: 107 KIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEA----GPPESAESTNI 162
KI++ L ++ L K V + ++ I V P + EA G E T++
Sbjct: 161 KIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDV 220
Query: 163 ---LKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGM 219
L+ PR R+ +NH R L +I+ N F L R G H D +
Sbjct: 221 KTFLEALPRAAVYRM-NRNH------------RGLCVIVNNHSFTSLKDRQGTHKDAEIL 267
Query: 220 KRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHK 279
+ Q LG+TV N+T +ME VL+ P H D +++HG G +
Sbjct: 268 SHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRF----GAVYS 323
Query: 280 KKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQS 339
+ + + + I F C L +KPK+ +QAC+GE E+ S + AL Q+
Sbjct: 324 SDEALIPIRE-IMSHFTALQCPRLAEKPKLFFIQACQGE---EIQPSVSIEADALNPEQA 379
Query: 340 SENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQK 389
+L+ DS I E DF+ ++ P VS+R GS +I L +K
Sbjct: 380 PTSLQ-DS---IPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKK 425
>gi|47078269 caspase 10 isoform b preproprotein [Homo sapiens]
Length = 521
Score = 77.0 bits (188), Expect = 3e-14
Identities = 64/223 (28%), Positives = 100/223 (44%), Gaps = 21/223 (9%)
Query: 186 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 245
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336
Query: 246 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 305
+ P H D +++HG G + + + + + I F C L +
Sbjct: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391
Query: 306 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 365
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444
Query: 366 HNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFE 408
VS+R GS +I L C HL ++ ++ K E
Sbjct: 445 GYVSFRHVEEGSWYIQSL---------CNHLKKLVPRMLKFLE 478
>gi|47078272 caspase 10 isoform d preproprotein [Homo sapiens]
Length = 522
Score = 75.5 bits (184), Expect = 9e-14
Identities = 60/204 (29%), Positives = 93/204 (45%), Gaps = 12/204 (5%)
Query: 186 KKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVL 245
+ + R L +I+ N F L R G H D + + Q LG+TV N+T +ME VL
Sbjct: 277 RMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVL 336
Query: 246 RAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKD 305
+ P H D +++HG G + + + + + I F C L +
Sbjct: 337 QKQKCNPAHADGDCFVFCILTHGRF----GAVYSSDEALIPIRE-IMSHFTALQCPRLAE 391
Query: 306 KPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTP 365
KPK+ +QAC+GE E+ S + AL Q+ +L+ DS I E DF+ ++ P
Sbjct: 392 KPKLFFIQACQGE---EIQPSVSIEADALNPEQAPTSLQ-DS---IPAEADFLLGLATVP 444
Query: 366 HNVSWRDRTRGSIFITELITCFQK 389
VS+R GS +I L +K
Sbjct: 445 GYVSFRHVEEGSWYIQSLCNHLKK 468
>gi|15718698 caspase 7 isoform delta [Homo sapiens]
Length = 336
Score = 74.7 bits (182), Expect = 2e-13
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 149 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 206
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 55 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 114
Query: 207 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 263
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 115 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 173
Query: 264 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 323
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 174 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 227
Query: 324 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 383
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 228 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 278
Query: 384 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 429
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 279 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 333
>gi|15718700 caspase 7 isoform alpha [Homo sapiens]
Length = 303
Score = 74.7 bits (182), Expect = 2e-13
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 149 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 206
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 22 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
Query: 207 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 263
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 82 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
Query: 264 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 323
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
Query: 324 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 383
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
Query: 384 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 429
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
>gi|4502581 caspase 7 isoform alpha precursor [Homo sapiens]
Length = 303
Score = 74.7 bits (182), Expect = 2e-13
Identities = 71/296 (23%), Positives = 125/296 (42%), Gaps = 32/296 (10%)
Query: 149 IEAGPPESAESTNILKLCPREEFLRLCKKNHDEI--YPIKKREDRRRLALIICNTKFDHL 206
++A P S+ ++ + +R K D + Y ++ +II N FD +
Sbjct: 22 VDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKV 81
Query: 207 PA---RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLV 263
RNG D + + + LG+ V+ + + M+ +L+ A+ +H ++ +
Sbjct: 82 TGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKK-ASEEDHTNAACFACI 140
Query: 264 LMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGEL 323
L+SHG I G K V + F C +L +KPK+ +QACRG + +
Sbjct: 141 LLSHGEENVIYG------KDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDG 194
Query: 324 WVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 383
DS + +A+ KI E DF+ S+ P SWR RGS F+ L
Sbjct: 195 IQADSGPI---------NDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQAL 245
Query: 384 ITCFQKYSCCCHLMEIFRKVQ----KSFEVP------QAKAQMPTIERATLTRDFY 429
+ +++ +M+I +V + FE K Q+P + + LT++ Y
Sbjct: 246 CSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVV-SMLTKELY 300
>gi|14790124 caspase 9 isoform alpha preproprotein [Homo sapiens]
Length = 416
Score = 73.6 bits (179), Expect = 3e-13
Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 28/244 (11%)
Query: 196 LIICNTKF---DHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARP 252
LII N F L R G++ D ++R L + V + +LTA+ M L A +
Sbjct: 164 LIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQ- 222
Query: 253 EHKSSDSTFLVLMSHGILEGICGTAHKKKKPDV-------LLYDTIFQIFNNRNCLSLKD 305
+H + D +V++SHG C +H + V + + I IFN +C SL
Sbjct: 223 DHGALDCCVVVILSHG-----CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGG 277
Query: 306 KPKVIIVQACRGEK--HGELWVRDSPASLALISSQSSENL----------EADSVCKIHE 353
KPK+ +QAC GE+ HG SP + S+ + + D++ +
Sbjct: 278 KPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPT 337
Query: 354 EKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAK 413
D S+ P VSWRD GS ++ L F++++ L + +V + V
Sbjct: 338 PSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIY 397
Query: 414 AQMP 417
QMP
Sbjct: 398 KQMP 401
>gi|14916483 caspase 6 isoform alpha preproprotein [Homo sapiens]
Length = 293
Score = 64.7 bits (156), Expect = 2e-10
Identities = 71/262 (27%), Positives = 109/262 (41%), Gaps = 34/262 (12%)
Query: 191 RRRLALIICNTKFDH---LPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRA 247
RR +ALI + +F LP R G D + R LG+ V +L A ++ +
Sbjct: 43 RRGIALIFNHERFFWHLTLPERRGTCADRDNLTRRFSDLGFEVKCFNDLKAEELLLKIHE 102
Query: 248 FAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKP 307
+ H +D V +SHG EG A+ K + T+ +F C SL KP
Sbjct: 103 VST-VSHADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKP 155
Query: 308 KVIIVQACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAF 360
K+ I+QACRG +H D P L ++ +Q+ + ++A SV + DF+
Sbjct: 156 KIFIIQACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMC 209
Query: 361 CSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA 412
S S R+ GS +I +L KY E+ V + + P A
Sbjct: 210 YSVAEGYYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSA 269
Query: 413 --KAQMPTIERATLTRDFYLFP 432
K Q+P + LT+ + FP
Sbjct: 270 IGKKQVPCF-ASMLTKKLHFFP 290
>gi|122056476 caspase 8 isoform G precursor [Homo sapiens]
Length = 538
Score = 59.3 bits (142), Expect = 7e-09
Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)
Query: 84 FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 136
F +L + ++ K ++ D IE +K +IL +D L+ RV Q+ ++LL +
Sbjct: 179 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 235
Query: 137 DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 191
D + S + +E P E + + + PRE+ + D++Y +K +
Sbjct: 236 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 291
Query: 192 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 241
R LII N F + +P RNG H D + + L + + + T +
Sbjct: 292 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 351
Query: 242 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 301
+L+ + +H + D ++SHG I GT ++ +Y+ Q F C
Sbjct: 352 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 405
Query: 302 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 357
SL KPKV +QAC+G+ + + P S+ LE D I +E DF
Sbjct: 406 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 458
Query: 358 IAFCSSTPHNVSWRDRTRGSIFITEL 383
+ ++ + VS+R+ G+ +I L
Sbjct: 459 LLGMATVNNCVSYRNPAEGTWYIQSL 484
>gi|15718706 caspase 8 isoform B precursor [Homo sapiens]
Length = 479
Score = 59.3 bits (142), Expect = 7e-09
Identities = 79/326 (24%), Positives = 139/326 (42%), Gaps = 46/326 (14%)
Query: 84 FNYLAKHDVLTLKEEEKKKYYDTKIE-DKALIL----VDSLRKNRVAHQMFTQTLLNM-- 136
F +L + ++ K ++ D IE +K +IL +D L+ RV Q+ ++LL +
Sbjct: 120 FKFLLQEEISKCKLDDDMNLLDIFIEMEKRVILGEGKLDILK--RVCAQI-NKSLLKIIN 176
Query: 137 DQKITSVKPLLQIEAGPPESAESTNILKLC-----PREEFLRLCKKNHDEIYPIKKREDR 191
D + S + +E P E + + + PRE+ + D++Y +K +
Sbjct: 177 DYEEFSKERSSSLEGSPDEFSNGEELCGVMTISDSPREQDSE--SQTLDKVYQMKSKP-- 232
Query: 192 RRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDM 241
R LII N F + +P RNG H D + + L + + + T +
Sbjct: 233 RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFEIKPHDDCTVEQI 292
Query: 242 ESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCL 301
+L+ + +H + D ++SHG I GT ++ +Y+ Q F C
Sbjct: 293 YEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYELTSQ-FTGLKCP 346
Query: 302 SLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD----SVCKIHEEKDF 357
SL KPKV +QAC+G+ + + P S+ LE D I +E DF
Sbjct: 347 SLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSSPQTRYIPDEADF 399
Query: 358 IAFCSSTPHNVSWRDRTRGSIFITEL 383
+ ++ + VS+R+ G+ +I L
Sbjct: 400 LLGMATVNNCVSYRNPAEGTWYIQSL 425
>gi|122056474 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 56.2 bits (134), Expect = 6e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 180 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 229
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
Query: 230 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 289
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320
Query: 290 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 346
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372
Query: 347 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 383
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
>gi|15718708 caspase 8 isoform C precursor [Homo sapiens]
Length = 464
Score = 56.2 bits (134), Expect = 6e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 180 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 229
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 208 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 265
Query: 230 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 289
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 266 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 320
Query: 290 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 346
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 321 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 372
Query: 347 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 383
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 373 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 410
>gi|15718704 caspase 8 isoform A precursor [Homo sapiens]
Length = 496
Score = 56.2 bits (134), Expect = 6e-08
Identities = 55/218 (25%), Positives = 93/218 (42%), Gaps = 29/218 (13%)
Query: 180 DEIYPIKKREDRRRLALIICNTKF----DHLPA------RNGAHYDIVGMKRLLQGLGYT 229
D++Y +K + R LII N F + +P RNG H D + + L +
Sbjct: 240 DKVYQMKSKP--RGYCLIINNHNFAKAREKVPKLHSIRDRNGTHLDAGALTTTFEELHFE 297
Query: 230 VVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYD 289
+ + T + +L+ + +H + D ++SHG I GT ++ +Y+
Sbjct: 298 IKPHDDCTVEQIYEILKIYQLM-DHSNMDCFICCILSHGDKGIIYGTDGQEAP----IYE 352
Query: 290 TIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEAD--- 346
Q F C SL KPKV +QAC+G+ + + P S+ LE D
Sbjct: 353 LTSQ-FTGLKCPSLAGKPKVFFIQACQGDN----YQKGIPVE---TDSEEQPYLEMDLSS 404
Query: 347 -SVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITEL 383
I +E DF+ ++ + VS+R+ G+ +I L
Sbjct: 405 PQTRYIPDEADFLLGMATVNNCVSYRNPAEGTWYIQSL 442
>gi|14916485 caspase 6 isoform beta [Homo sapiens]
Length = 204
Score = 54.3 bits (129), Expect = 2e-07
Identities = 54/196 (27%), Positives = 82/196 (41%), Gaps = 30/196 (15%)
Query: 254 HKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQ 313
H +D V +SHG EG A+ K + T+ +F C SL KPK+ I+Q
Sbjct: 19 HADADCFVCVFLSHG--EGNHIYAYDAK----IEIQTLTGLFKGDKCHSLVGKPKIFIIQ 72
Query: 314 ACRGEKHGELWVRDSPA-SLALISSQSSE------NLEADSVCKIHEEKDFIAFCSSTPH 366
ACRG +H D P L ++ +Q+ + ++A SV + DF+ S
Sbjct: 73 ACRGNQH------DVPVIPLDVVDNQTEKLDTNITEVDAASVYTLPAGADFLMCYSVAEG 126
Query: 367 NVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSF--------EVPQA--KAQM 416
S R+ GS +I +L KY E+ V + + P A K Q+
Sbjct: 127 YYSHRETVNGSWYIQDLCEMLGKYGSSLEFTELLTLVNRKVSQRRVDFCKDPSAIGKKQV 186
Query: 417 PTIERATLTRDFYLFP 432
P + LT+ + FP
Sbjct: 187 PCF-ASMLTKKLHFFP 201
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,879,321
Number of Sequences: 37866
Number of extensions: 666749
Number of successful extensions: 1761
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 39
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1667
Number of HSP's gapped (non-prelim): 78
length of query: 434
length of database: 18,247,518
effective HSP length: 105
effective length of query: 329
effective length of database: 14,271,588
effective search space: 4695352452
effective search space used: 4695352452
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.