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Search of human proteins with 209862975
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209862975 MAP-kinase activating death domain-containing
protein isoform b [Homo sapiens]
(1565 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209862975 MAP-kinase activating death domain-containing prote... 3112 0.0
gi|209862983 MAP-kinase activating death domain-containing prote... 3091 0.0
gi|209862994 MAP-kinase activating death domain-containing prote... 3065 0.0
gi|209862979 MAP-kinase activating death domain-containing prote... 3061 0.0
gi|209862998 MAP-kinase activating death domain-containing prote... 3055 0.0
gi|209863002 MAP-kinase activating death domain-containing prote... 3049 0.0
gi|209862971 MAP-kinase activating death domain-containing prote... 3041 0.0
gi|209571517 MAP-kinase activating death domain-containing prote... 3034 0.0
gi|18860873 MAP-kinase activating death domain-containing protei... 2918 0.0
gi|209862987 MAP-kinase activating death domain-containing prote... 2914 0.0
gi|239735519 SET binding factor 1 [Homo sapiens] 103 1e-21
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 90 2e-17
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 90 2e-17
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 84 1e-15
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 77 1e-13
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 77 1e-13
gi|29788755 SET binding factor 2 [Homo sapiens] 77 2e-13
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 72 3e-12
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 72 3e-12
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 62 6e-09
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 62 6e-09
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 62 6e-09
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 59 5e-08
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 58 6e-08
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 58 6e-08
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 56 3e-07
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 55 5e-07
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 52 3e-06
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 51 8e-06
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 49 4e-05
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 3112 bits (8069), Expect = 0.0
Identities = 1565/1565 (100%), Positives = 1565/1565 (100%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900
KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ
Sbjct: 841 KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900
Query: 901 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960
FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI
Sbjct: 901 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960
Query: 961 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020
SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES
Sbjct: 961 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020
Query: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080
VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE
Sbjct: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080
Query: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140
VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV
Sbjct: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140
Query: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200
SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP
Sbjct: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200
Query: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260
SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD
Sbjct: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260
Query: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320
QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK
Sbjct: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320
Query: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380
SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD
Sbjct: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380
Query: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440
DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV
Sbjct: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440
Query: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1500
KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI
Sbjct: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1500
Query: 1501 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1560
KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP
Sbjct: 1501 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1560
Query: 1561 RPVSS 1565
RPVSS
Sbjct: 1561 RPVSS 1565
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 3091 bits (8015), Expect = 0.0
Identities = 1565/1608 (97%), Positives = 1565/1608 (97%), Gaps = 43/1608 (2%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 857
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 858 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 917
GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 918 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 977
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 978 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1037
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1038 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1097
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1140
Query: 1098 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1157
ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN
Sbjct: 1141 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1200
Query: 1158 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1217
AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV
Sbjct: 1201 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1260
Query: 1218 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1277
SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD
Sbjct: 1261 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1320
Query: 1278 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1337
RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ
Sbjct: 1321 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1380
Query: 1338 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1397
LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW
Sbjct: 1381 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1440
Query: 1398 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1457
YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG
Sbjct: 1441 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1500
Query: 1458 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1517
PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP
Sbjct: 1501 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1560
Query: 1518 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1565
EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1561 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1608
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 3065 bits (7946), Expect = 0.0
Identities = 1564/1647 (94%), Positives = 1564/1647 (94%), Gaps = 82/1647 (4%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 857
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 858 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 917
GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 918 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 977
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 978 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1037
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1038 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIG------------------P 1079
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
Query: 1080 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1139
EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
Query: 1140 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1199
VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
Query: 1200 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1238
PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG KERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
Query: 1239 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1298
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
Query: 1299 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1358
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
Query: 1359 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1418
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
Query: 1419 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1478
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
Query: 1479 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1538
VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
Query: 1539 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1565
VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 3061 bits (7937), Expect = 0.0
Identities = 1545/1565 (98%), Positives = 1545/1565 (98%), Gaps = 20/1565 (1%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900
K GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ
Sbjct: 841 K--------------------GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 880
Query: 901 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960
FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI
Sbjct: 881 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 940
Query: 961 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020
SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES
Sbjct: 941 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1000
Query: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080
VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE
Sbjct: 1001 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1060
Query: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140
VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV
Sbjct: 1061 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1120
Query: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200
SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP
Sbjct: 1121 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1180
Query: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260
SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD
Sbjct: 1181 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1240
Query: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320
QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK
Sbjct: 1241 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1300
Query: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380
SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD
Sbjct: 1301 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1360
Query: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440
DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV
Sbjct: 1361 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1420
Query: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1500
KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI
Sbjct: 1421 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1480
Query: 1501 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1560
KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP
Sbjct: 1481 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1540
Query: 1561 RPVSS 1565
RPVSS
Sbjct: 1541 RPVSS 1545
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 3055 bits (7921), Expect = 0.0
Identities = 1544/1565 (98%), Positives = 1544/1565 (98%), Gaps = 21/1565 (1%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900
K GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ
Sbjct: 841 K--------------------GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 880
Query: 901 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960
FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI
Sbjct: 881 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 940
Query: 961 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020
SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES
Sbjct: 941 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1000
Query: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080
VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE
Sbjct: 1001 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1060
Query: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140
VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST V
Sbjct: 1061 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST-V 1119
Query: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200
SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP
Sbjct: 1120 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1179
Query: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260
SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD
Sbjct: 1180 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1239
Query: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320
QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK
Sbjct: 1240 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1299
Query: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380
SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD
Sbjct: 1300 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1359
Query: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440
DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV
Sbjct: 1360 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1419
Query: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1500
KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI
Sbjct: 1420 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1479
Query: 1501 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1560
KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP
Sbjct: 1480 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1539
Query: 1561 RPVSS 1565
RPVSS
Sbjct: 1540 RPVSS 1544
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 3049 bits (7905), Expect = 0.0
Identities = 1541/1565 (98%), Positives = 1541/1565 (98%), Gaps = 24/1565 (1%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900
K GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ
Sbjct: 841 K--------------------GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 880
Query: 901 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960
FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI
Sbjct: 881 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 940
Query: 961 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020
SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES
Sbjct: 941 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1000
Query: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080
VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE
Sbjct: 1001 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1060
Query: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140
VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE V
Sbjct: 1061 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSE----V 1116
Query: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200
SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP
Sbjct: 1117 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1176
Query: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260
SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD
Sbjct: 1177 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1236
Query: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320
QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK
Sbjct: 1237 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1296
Query: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380
SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD
Sbjct: 1297 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1356
Query: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440
DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV
Sbjct: 1357 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1416
Query: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1500
KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI
Sbjct: 1417 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHI 1476
Query: 1501 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1560
KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP
Sbjct: 1477 KKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPP 1536
Query: 1561 RPVSS 1565
RPVSS
Sbjct: 1537 RPVSS 1541
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 3041 bits (7883), Expect = 0.0
Identities = 1545/1608 (96%), Positives = 1545/1608 (96%), Gaps = 63/1608 (3%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 857
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 884
Query: 858 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 917
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 885 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 940
Query: 918 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 977
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 941 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1000
Query: 978 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1037
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1001 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1060
Query: 1038 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1097
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ
Sbjct: 1061 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1120
Query: 1098 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1157
ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN
Sbjct: 1121 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1180
Query: 1158 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1217
AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV
Sbjct: 1181 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1240
Query: 1218 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1277
SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD
Sbjct: 1241 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1300
Query: 1278 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1337
RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ
Sbjct: 1301 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1360
Query: 1338 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1397
LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW
Sbjct: 1361 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1420
Query: 1398 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1457
YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG
Sbjct: 1421 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1480
Query: 1458 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1517
PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP
Sbjct: 1481 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1540
Query: 1518 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1565
EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1541 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1588
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 3034 bits (7867), Expect = 0.0
Identities = 1544/1608 (96%), Positives = 1544/1608 (96%), Gaps = 64/1608 (3%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 857
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 884
Query: 858 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 917
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 885 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 940
Query: 918 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 977
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 941 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1000
Query: 978 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1037
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1001 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1060
Query: 1038 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1097
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ
Sbjct: 1061 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1120
Query: 1098 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1157
ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV SNSSGETLGADSDLSSN
Sbjct: 1121 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV-SNSSGETLGADSDLSSN 1179
Query: 1158 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1217
AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV
Sbjct: 1180 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1239
Query: 1218 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1277
SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD
Sbjct: 1240 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1299
Query: 1278 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1337
RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ
Sbjct: 1300 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1359
Query: 1338 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1397
LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW
Sbjct: 1360 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1419
Query: 1398 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1457
YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG
Sbjct: 1420 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1479
Query: 1458 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1517
PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP
Sbjct: 1480 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1539
Query: 1518 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1565
EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1540 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 2918 bits (7564), Expect = 0.0
Identities = 1493/1579 (94%), Positives = 1495/1579 (94%), Gaps = 83/1579 (5%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 857
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 858 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 917
GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 918 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 977
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 978 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1037
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1038 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1079
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
Query: 1080 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1139
EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
Query: 1140 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1199
VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
Query: 1200 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1238
PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG KERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
Query: 1239 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1298
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
Query: 1299 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1358
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
Query: 1359 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1418
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
Query: 1419 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1478
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
Query: 1479 VTLEGINLKFMHNQVFIEL 1497
VTLEGINLKFMHNQ F++L
Sbjct: 1561 VTLEGINLKFMHNQ-FLKL 1578
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 2914 bits (7555), Expect = 0.0
Identities = 1474/1497 (98%), Positives = 1476/1497 (98%), Gaps = 21/1497 (1%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAE 780
Query: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL
Sbjct: 781 SDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSL 840
Query: 841 KVFGLNTLMEIVTEAGPGSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 900
K GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ
Sbjct: 841 K--------------------GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQ 880
Query: 901 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 960
FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI
Sbjct: 881 FLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEI 940
Query: 961 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1020
SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES
Sbjct: 941 SRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTES 1000
Query: 1021 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1080
VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE
Sbjct: 1001 VNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPE 1060
Query: 1081 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1140
VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV
Sbjct: 1061 VIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVV 1120
Query: 1141 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1200
SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP
Sbjct: 1121 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKP 1180
Query: 1201 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1260
SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD
Sbjct: 1181 SIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMD 1240
Query: 1261 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1320
QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK
Sbjct: 1241 QGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGK 1300
Query: 1321 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1380
SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD
Sbjct: 1301 SHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCD 1360
Query: 1381 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1440
DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV
Sbjct: 1361 DCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCV 1420
Query: 1441 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIEL 1497
KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ F++L
Sbjct: 1421 KDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQ-FLKL 1476
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 103 bits (257), Expect = 1e-21
Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)
Query: 10 RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68
RL DY V+V HP Q ++L+R+P +D + P P + FCQP G +R
Sbjct: 3 RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
Query: 69 MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128
T FV LTD ++ Y C+ F+ + +E T
Sbjct: 61 ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
Query: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188
E TE E G D + SP A + TL + L H F
Sbjct: 99 -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
Query: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247
+Y + ++ C E ++G
Sbjct: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
Query: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304
LL VP++G + I + Q +Q L +LP SR ++ L L
Sbjct: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
G+ L + L EHKV+ SR Y L+ + +A+++PL Y F +P+LP A
Sbjct: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424
++L PTP+IIGV A+F + + + DV + DLD V P E + I P PE L+
Sbjct: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
Query: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484
+ H + +S+ P L L DL P P + +
Sbjct: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
Query: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532
D R +R F A +LQG++ +R+ P PV+ F +FL R
Sbjct: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
+ YG + FY + SEE TE
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
+ G + L +E+ S +H + P P
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
+ YG + FY + SEE TE
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
+ G + L +E+ S +H + P P
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
G YG + FY +F + E+ +
Sbjct: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
RL +E S +H++ P P
Sbjct: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
Query: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
F P DV VDLD+N + ++L
Sbjct: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 77.4 bits (189), Expect = 1e-13
Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)
Query: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223
K S+S N T +C+LSH+PFF FR+ L + +L + P
Sbjct: 65 KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
Query: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283
L +E+ S + ++ P P + R+ +++ + AL +
Sbjct: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
Query: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
P + L L LG + C +L +LLE K++L S L+ A VAMI
Sbjct: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
+P ++ P IPL P +A+ +L AP P+I+GV + +F P DV +DLD+N
Sbjct: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
Query: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458
+ N + LP P L K L L+S+ TQ EG I +
Sbjct: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
Query: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517
TP +F+ + + +++ + A +RF A++L+G++ + R + P
Sbjct: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
Query: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
F FL SR R F L++TQ
Sbjct: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 77.0 bits (188), Expect = 1e-13
Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)
Query: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344
P PS L D+PL ELLG++ +QV TC+LLE +++L S+DY L +++
Sbjct: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
Query: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402
P ++ +P+LP AS L AP PY++G+ + + ++P + L VD+D++
Sbjct: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
Query: 403 RVIAPTNAEVLP 414
+ P P
Sbjct: 376 FIELPEEFPQFP 387
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 76.6 bits (187), Expect = 2e-13
Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 49/252 (19%)
Query: 292 LVDFPLH--LPL---------ELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFV 340
L+ PLH LP+ + LG+ L + +L E+KV+ S + LS + A
Sbjct: 183 LIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALE 242
Query: 341 AMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLD 400
++++PL+Y +P IP+LP A ++L +PTP+IIGV + F K D DV + DLD
Sbjct: 243 SLMFPLKYSYPYIPILP---AQLLEVLSSPTPFIIGVHSVF---KTDVHELLDVIIADLD 296
Query: 401 SNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGR 460
+ P L LPEP L Q +++SL P
Sbjct: 297 GGTIKIPECIH-LSSLPEPL-------LHQTQSALSLILHP------------------- 329
Query: 461 PSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPV 520
DL+ P + +D R +R F A + QG++ + +R+ PV
Sbjct: 330 ---DLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLF--AQLFQGYRSCLQLIRIHAEPV 384
Query: 521 VAFQAGSFLASR 532
+ F +FL R
Sbjct: 385 IHFHKTAFLGQR 396
Score = 56.2 bits (134), Expect = 2e-07
Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 7/111 (6%)
Query: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRM 69
RL DY ++VG H S ++++R+P +D + P P + FCQP G R+R
Sbjct: 3 RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER-- 60
Query: 70 SLRDDTSFVFTLTDKDTGVTRYGICVNFYRS--FQKRISKEKGEGGAGSRG 118
+ T FV LTD D+ Y C+ FY + + KE+ EG A G
Sbjct: 61 --KQPTFFVVVLTDIDSD-RHYCSCLTFYEAEINLQGTKKEEIEGEAKVSG 108
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
Query: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
Query: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
Query: 423 ELKKHLKQALASMSL 437
E + + + L + +
Sbjct: 406 EFVQEVSEILMAFGI 420
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 72.4 bits (176), Expect = 3e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
Query: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
L+ SP P V K + I VLP P
Sbjct: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
Query: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
Query: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 948 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 948 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 58.5 bits (140), Expect = 5e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 58.2 bits (139), Expect = 6e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
Score = 31.2 bits (69), Expect = 8.2
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
Query: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
+ ++ TS F F LT +D G R+G C
Sbjct: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 58.2 bits (139), Expect = 6e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
Query: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
+F SL + S L L S V VS + + +P F P
Sbjct: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
Query: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
Query: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
+ T +V + P+ SL + K ALA
Sbjct: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 55.8 bits (133), Expect = 3e-07
Identities = 62/261 (23%), Positives = 110/261 (42%), Gaps = 45/261 (17%)
Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
LC+LS+ P+F + + L TL L +E
Sbjct: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDI---EVLPQE--LQPALTFALPDPSRFT 291
+ L LR + +PV +S + + I +VL + L P F PD +
Sbjct: 123 ENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLP 182
Query: 292 LVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYM 349
+ +L + VD LQ+ +L E ++V+ S + L+ + A++YP+ +
Sbjct: 183 TIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQ 242
Query: 350 FPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN 409
IP+LP + AP PY+IG+ +S + ++ K +DV ++++D+N + +P +
Sbjct: 243 HIYIPVLPPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFS 298
Query: 410 AEVLPILPEPESLELKKHLKQ 430
L LP LK LK+
Sbjct: 299 D--LNNLPSDVVSALKNKLKK 317
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 55.1 bits (131), Expect = 5e-07
Identities = 59/225 (26%), Positives = 96/225 (42%), Gaps = 15/225 (6%)
Query: 598 NSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNV 657
+S +++ S SDS+ +D SDS D D S SS SS S+ + D+ +
Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD- 621
Query: 658 DPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGA 717
+ D+S+ E D + +++ +S +S +N SS+++ SS S
Sbjct: 622 ------SKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSD----- 670
Query: 718 NSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDS 777
+S+ +DS+ D + S S S + D + + + NS SDS
Sbjct: 671 SSDSSDSSSSSDSS--NSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDS 728
Query: 778 DAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
SDS SS NS+ S+ S++ S SS N S S S+
Sbjct: 729 SNSSDSSDSS-NSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD 772
Score = 54.3 bits (129), Expect = 9e-07
Identities = 54/230 (23%), Positives = 92/230 (40%), Gaps = 21/230 (9%)
Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656
SNS + S S+ +D S SDS D DSS+S SS D + D + + +
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743
Query: 657 VDPLTHAALGDASEVE----IDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712
D + D+S+ + + ++ + S +S N SS S+ +S+S +
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803
Query: 713 VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLR 772
+S+ +DS++ D + S S S + D + G
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDG------------- 850
Query: 773 LASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
SD++S +R+ S NS+ S+ S++ S SS S S S+
Sbjct: 851 ----SDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSD 896
Score = 51.6 bits (122), Expect = 6e-06
Identities = 56/227 (24%), Positives = 94/227 (41%), Gaps = 5/227 (2%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DSN + S SDS + DS SDS D DS SS SS D + D + +
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDS-SDSSDSSDSDSSNSS--DSSNSSDSSDSSNSSD 840
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ D + D+ + N ++ + DS NS ++ S+ ++ SS S +
Sbjct: 841 SSDSSDSSDGSDSDSSNRSDSSNSSDSSDSS-DSSNSSDSSDSSDSNESSNSSDSSDSSN 899
Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLAS 775
++S+ +DS+ D + S S SN + + + NS ++
Sbjct: 900 SSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSN-SSDSSNSSDSSDSSDSSNSSDSSN 958
Query: 776 DSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
SD+ + S +S NS+ S+ S+ S SS + S S + S+
Sbjct: 959 SSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSD 1005
Score = 51.2 bits (121), Expect = 8e-06
Identities = 58/222 (26%), Positives = 91/222 (40%), Gaps = 8/222 (3%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSS----SSYSSLGDFVSEMMKCDIN 651
DS S +++ S + DS S+ +D + SDS D DSS SS SS S+ +
Sbjct: 621 DSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSS 680
Query: 652 GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711
D+ N + ++ S D + DS NS + S+SS ++ SS S
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740
Query: 712 TVIHGAN--SEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNV-DRRQAEIGEGAQKLLRP 768
+ ++ S +DS++ D + S S SN D + +
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNS 800
Query: 769 NSLRLASDSDAESDSRAS-SPNSTVSNTSTEGFGGIMSFASS 809
+ +SDS SDS S S NS+ S+ S++ S SS
Sbjct: 801 SDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSS 842
Score = 50.1 bits (118), Expect = 2e-05
Identities = 56/228 (24%), Positives = 89/228 (39%), Gaps = 7/228 (3%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS++ + S SDS + DS S D S SS SS S+ + D+
Sbjct: 760 DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD 819
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ + + D+S+ + G DS++S + SS S+ +S S ++
Sbjct: 820 SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879
Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDR-RQAEIGEGAQKLLRPNSLRLA 774
+S+ +S+ D + S S S + D ++ E + NS
Sbjct: 880 SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNS---- 935
Query: 775 SDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
SDS SDS SS +S S++S S +S N S S SN
Sbjct: 936 SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD--SNSSDSSDSSN 981
Score = 49.7 bits (117), Expect = 2e-05
Identities = 52/225 (23%), Positives = 89/225 (39%), Gaps = 5/225 (2%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + DS SDS D DSS S S D + D + +
Sbjct: 1077 DSSDSSESSDSSDSSNSSDSSDSSDS-SDSSDSSDSSDSSDS-SDSSNSSDSSDSSDSSD 1134
Query: 656 NVDPLTHAALGDASEV-EIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
+ D + D+SE + + + ++ + S++S + SS S+ +S S +
Sbjct: 1135 SSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1194
Query: 715 HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS--NVDRRQAEIGEGAQKLLRPNSLR 772
+S+ +DS++ D + S S S N ++ + + +S
Sbjct: 1195 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSD 1254
Query: 773 LASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTS 817
+ SD+ SDS S + + S S + NHSTS
Sbjct: 1255 SSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTS 1299
Score = 48.9 bits (115), Expect = 4e-05
Identities = 51/213 (23%), Positives = 89/213 (41%), Gaps = 12/213 (5%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS-------GSDSMDYDDSSSSYSSLGDFVSEMMKC 648
DS+S + + S DSDS + DS SDS D DSS S S S+
Sbjct: 568 DSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS 627
Query: 649 DINGDTPNVDPLTHAALGDASEV----EIDELQNQKEAEEPGPDSENSQENPPLRSSSST 704
D+ + D + ++ ++S+ + + N + + S++S + SS+S+
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687
Query: 705 TASSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKS-NVDRRQAEIGEGAQ 763
+S S + +S+ +DS++ D + S S S S + D + +
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Query: 764 KLLRPNSLRLASDSDAESDSRASSPNSTVSNTS 796
+ +SDS SDS SS +S S++S
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSS 780
Score = 48.1 bits (113), Expect = 6e-05
Identities = 47/217 (21%), Positives = 88/217 (40%), Gaps = 3/217 (1%)
Query: 606 SVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAAL 665
S +SDS ++G+D D DS S D S+ + D+ + +
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSD--SDSSDSSNSSDSSDSSDSDSSDS 574
Query: 666 GDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADST 725
+S+ + + + ++ DS NS ++ SS ++ SS S ++ +DS+
Sbjct: 575 NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634
Query: 726 EMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRA 785
+ D K+ S S S + + + + +S +S+S SDS
Sbjct: 635 DSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSD 694
Query: 786 SSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
SS NS+ S+ S++ S +S ++S+ SN
Sbjct: 695 SS-NSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSN 730
Score = 47.8 bits (112), Expect = 8e-05
Identities = 51/221 (23%), Positives = 94/221 (42%), Gaps = 11/221 (4%)
Query: 610 ERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALG--- 666
E D++S D+ +S + D+ + S G +E D DT N D + G
Sbjct: 480 ESDNNSSSRGDASYNSDESKDNGNGSDSKG---AEDDDSDSTSDTNNSDSNGNGNNGNDD 536
Query: 667 ----DASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPA 722
D+ + + D + DS +S ++ S+SS+ + SS S ++S+ +
Sbjct: 537 NDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSS 596
Query: 723 DSTEMDDKA-AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLASDSDAES 781
DS+ D + + S S S KS+ + +++ + K +S S +++S
Sbjct: 597 DSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDS 656
Query: 782 DSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
++S NS+ S+ S++ S SS + S S SN
Sbjct: 657 SDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697
Score = 47.0 bits (110), Expect = 1e-04
Identities = 49/202 (24%), Positives = 81/202 (40%), Gaps = 4/202 (1%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS++ + S SDS + DS S D S SS SS D D + +
Sbjct: 860 DSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSN 919
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ D + D S + N ++ + DS NS ++ SS+++ SS ++
Sbjct: 920 SSDSSESSNSSDNS--NSSDSSNSSDSSD-SSDSSNSSDSSNSSDSSNSSDSSDSNSSDS 976
Query: 716 GANSEPADSTEMDDKA-AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLA 774
+S +DS++ D + + S S S + D + + + +
Sbjct: 977 SDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDS 1036
Query: 775 SDSDAESDSRASSPNSTVSNTS 796
SDS SDS SS +S SN+S
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSS 1058
Score = 46.6 bits (109), Expect = 2e-04
Identities = 53/232 (22%), Positives = 93/232 (40%), Gaps = 5/232 (2%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS--GSDSMDYDDS--SSSYSSLGDFVSEMMKCDIN 651
DS++ + S SDS + DS SDS D DS SS S+ D D +
Sbjct: 736 DSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795
Query: 652 GDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPS 711
+ + D + D+S+ + N ++ S++S + SS S+ S S S
Sbjct: 796 DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855
Query: 712 TVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSL 771
+ +++ S D + S S S + D + + + +S
Sbjct: 856 SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915
Query: 772 RLASDSD-AESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSN 822
++ SD +ES + + + NS+ S+ S++ S SS N S S + S+
Sbjct: 916 DSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSD 967
Score = 45.8 bits (107), Expect = 3e-04
Identities = 48/202 (23%), Positives = 83/202 (41%), Gaps = 5/202 (2%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + DS S D S SS SS S+ + D+
Sbjct: 1062 DSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1121
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
N + ++ D+S+ + N ++ + S++S + SS S+ +S S +
Sbjct: 1122 NSSDSSDSS--DSSDSS--DSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDS 1177
Query: 716 GANSEPADSTEMDDKA-AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLA 774
+S+ +DS++ D + + S S S + D + + N +
Sbjct: 1178 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDS 1237
Query: 775 SDSDAESDSRASSPNSTVSNTS 796
SDS SDS SS +S S++S
Sbjct: 1238 SDSSDSSDSSNSSDSSDSSDSS 1259
Score = 45.4 bits (106), Expect = 4e-04
Identities = 51/208 (24%), Positives = 83/208 (39%), Gaps = 13/208 (6%)
Query: 597 SNSQLAEALSVPPERDSDSEPTDDSG--------SDSMDYDDSSSSYSSLGDFVSEMMKC 648
SNS +++ S SDS + DS SDS D DSS+S S D
Sbjct: 719 SNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS-SDSSDSSDSS 777
Query: 649 DINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASS 708
D + + + D + D+S + DS++S + SS S+ +S+
Sbjct: 778 DSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN 837
Query: 709 SPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRP 768
S + +S+ +D ++ D S S S ++ D + +
Sbjct: 838 SSDS---SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDS 894
Query: 769 NSLRLASDSDAESDSRASSPNSTVSNTS 796
+ +SDSD+ SDS SS +S SN+S
Sbjct: 895 SDSSNSSDSDS-SDSSNSSDSSDSSNSS 921
Score = 45.4 bits (106), Expect = 4e-04
Identities = 51/201 (25%), Positives = 82/201 (40%), Gaps = 13/201 (6%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS++ + S SDS + DS S+S D DS+SS SS D + D + +
Sbjct: 937 DSSNSSDSSDSSDSSNSSDSSNSSDS-SNSSDSSDSNSSDSS--DSSNSSDSSDSSDSSD 993
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ D + D+S+ + DS NS ++ SS ++ SS S
Sbjct: 994 SSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1053
Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLAS 775
+NS +DS++ D + S S + D ++ + + +S
Sbjct: 1054 SSNS--SDSSDSSDSS--------DSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103
Query: 776 DSDAESDSRASSPNSTVSNTS 796
DS SDS SS +S SN+S
Sbjct: 1104 DSSDSSDSSDSSDSSDSSNSS 1124
Score = 45.4 bits (106), Expect = 4e-04
Identities = 49/202 (24%), Positives = 85/202 (42%), Gaps = 14/202 (6%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS++ + S SDS + DS SDS D DSS+S S D + +
Sbjct: 1020 DSSNSSDSSNSSDSSDSSDSSDSSDS-SDSSDSSDSSNSSDS----------SDSSDSSD 1068
Query: 656 NVDPLTHAALGDASE-VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
+ D + D+SE + + N ++ + S++S + SS S+ +S+S +
Sbjct: 1069 SSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD 1128
Query: 715 HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLA 774
+S+ +DS+ D + S+ S S + D + + + +
Sbjct: 1129 SSDSSDSSDSSNSSDSS--DSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1186
Query: 775 SDSDAESDSRASSPNSTVSNTS 796
SDS SDS SS +S S++S
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSS 1208
Score = 45.4 bits (106), Expect = 4e-04
Identities = 56/238 (23%), Positives = 93/238 (39%), Gaps = 15/238 (6%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS--GSDSMDYDDSSSSYSSLGDFVSEMMKCDINGD 653
DS+ + S SDS + DS SDS D DSS S S D D +
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS-SESSDSSDSSNSSDSSDS 1099
Query: 654 TPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTV 713
+ + D + D+S + + N ++ + S++S + SS S+ +S S +
Sbjct: 1100 SDSSDSSDSSDSSDSS--DSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSS 1157
Query: 714 IHGANSEPADSTEMDDKA----------AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQ 763
+S+ +DS++ D + + S S S + D + +
Sbjct: 1158 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1217
Query: 764 KLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLS 821
+ +SDS+ SDS SS +S SN+S S ++S + S S S S
Sbjct: 1218 DSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275
Score = 45.1 bits (105), Expect = 5e-04
Identities = 49/202 (24%), Positives = 84/202 (41%), Gaps = 4/202 (1%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+++ + S SDS + DS SDS D ++SS+S S S D + +
Sbjct: 854 DSSNRSDSSNSSDSSDSSDSSNSSDS-SDSSDSNESSNSSDSSDS--SNSSDSDSSDSSN 910
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ D + D+SE + DS +S ++ SS+++ SS+ S
Sbjct: 911 SSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970
Query: 716 GANSEPADSTEMDDKA-AVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLA 774
+S+ +DS+ D + + S S S + D + + + +
Sbjct: 971 SNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNS 1030
Query: 775 SDSDAESDSRASSPNSTVSNTS 796
SDS SDS SS +S S++S
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSS 1052
Score = 44.7 bits (104), Expect = 7e-04
Identities = 46/201 (22%), Positives = 82/201 (40%), Gaps = 15/201 (7%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + DS + S D S SS SS D D + +
Sbjct: 1113 DSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS--DSSDSSDSSDSSDSSD 1170
Query: 656 NVDPLTHAALGDASE-VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
+ D + D+S+ + + + ++ + S++S + SS S+ +S S +
Sbjct: 1171 SSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1230
Query: 715 HGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDR-RQAEIGEGAQKLLRPNSLRL 773
+S+ +DS++ D + S S SN + Q++ G G
Sbjct: 1231 SNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNN---------- 1280
Query: 774 ASDSDAESDSRASSPNSTVSN 794
+ SD++SDS S N + S+
Sbjct: 1281 -NGSDSDSDSEGSDSNHSTSD 1300
Score = 43.1 bits (100), Expect = 0.002
Identities = 46/201 (22%), Positives = 82/201 (40%), Gaps = 12/201 (5%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + +S S D S+SS SS D D + +
Sbjct: 993 DSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS--DSSDSSDSSDSSDSSD 1050
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ D + D+S + + ++ + S++S+ + SS+S+ +S S +
Sbjct: 1051 SSDSSNSSDSSDSS-----DSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS 1105
Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGAQKLLRPNSLRLAS 775
+S+ +DS++ D S S S + D + + + + +S
Sbjct: 1106 SDSSDSSDSSDSSDS-----SNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSS 1160
Query: 776 DSDAESDSRASSPNSTVSNTS 796
DS SDS SS +S SN+S
Sbjct: 1161 DSSDSSDSSDSSDSSDSSNSS 1181
Score = 39.3 bits (90), Expect = 0.030
Identities = 36/108 (33%), Positives = 47/108 (43%), Gaps = 4/108 (3%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRS---SSQDSEVSTVVSNS 1143
D + S S+DS S SS DS G RS +S DS S+ SNS
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876
Query: 1144 SGETLGADSDLSSNAGDGPGGEGSVHLASS-RGTLSDSEIETNSATST 1190
S + +DS+ SSN+ D S SS SDS +NS+ S+
Sbjct: 877 SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSS 924
Score = 37.7 bits (86), Expect = 0.088
Identities = 50/201 (24%), Positives = 82/201 (40%), Gaps = 20/201 (9%)
Query: 618 TDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQ 677
++ G DS D+DD S GD + + + N D + ++ GDAS +
Sbjct: 445 SNSDGYDSYDFDDKSMQ----GDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKD 500
Query: 678 NQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSK 737
N ++ G + ++S S+S T S S N + + +DK+ G K
Sbjct: 501 NGNGSDSKGAEDDDSD------STSDTNNSDS--------NGNGNNGNDDNDKSDSGKGK 546
Query: 738 PLPSVPPSIGKSN-VDRRQAEIGEGAQKLLRPNSLRLASDSDAESDSRAS-SPNSTVSNT 795
S S SN D + + + +S SDS SDS +S S NS+ S+
Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD 606
Query: 796 STEGFGGIMSFASSLYRNHST 816
S++ S SS ++ S+
Sbjct: 607 SSDSSDSSDSSDSSDSKSDSS 627
Score = 37.4 bits (85), Expect = 0.11
Identities = 34/105 (32%), Positives = 48/105 (45%), Gaps = 6/105 (5%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S S S DS S+ S+SS + G+
Sbjct: 792 SDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGS 851
Query: 1151 DSDLS-----SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DSD S SN+ D S + + S + SDS +NS+ S+
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS-SDSNESSNSSDSS 895
Score = 37.0 bits (84), Expect = 0.15
Identities = 28/99 (28%), Positives = 44/99 (44%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS + S S DS S+ S+SS + +
Sbjct: 936 SDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSS 995
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1189
DS SSN+ D S ++S + + S+ +S +S
Sbjct: 996 DSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 1034
Score = 36.6 bits (83), Expect = 0.20
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 4/101 (3%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS + S+S DS S S+SS + +
Sbjct: 783 SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS---SDSSDSSNSS 839
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGT-LSDSEIETNSATST 1190
DS SS++ DG + S SS + SDS +NS+ S+
Sbjct: 840 DSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880
Score = 36.6 bits (83), Expect = 0.20
Identities = 30/95 (31%), Positives = 43/95 (45%), Gaps = 4/95 (4%)
Query: 1096 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1155
S S+DS S SS +S + SS DS S+ S+SS + +DS S
Sbjct: 867 SSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSES 926
Query: 1156 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
SN+ D S + + S SDS +NS+ S+
Sbjct: 927 SNSSDNSNSSDSSNSSDS----SDSSDSSNSSDSS 957
Score = 36.6 bits (83), Expect = 0.20
Identities = 31/95 (32%), Positives = 44/95 (46%), Gaps = 1/95 (1%)
Query: 1096 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1155
S S+DS S SS + S S S S DS S+ SNSS + +DS S
Sbjct: 956 SSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1015
Query: 1156 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
SN+ D S + + S + SDS ++S+ S+
Sbjct: 1016 SNSSDSSNSSDSSNSSDSSDS-SDSSDSSDSSDSS 1049
Score = 36.6 bits (83), Expect = 0.20
Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 11/126 (8%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S S DS S+ S+SS +
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDS-----------SDSSDSSDSSDSSDSSDSNESS 1235
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSP 1210
DS SS++ D S + S + SDS E++S + + G + + + S
Sbjct: 1236 DSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295
Query: 1211 IRTSED 1216
TS+D
Sbjct: 1296 HSTSDD 1301
Score = 36.2 bits (82), Expect = 0.26
Identities = 34/101 (33%), Positives = 46/101 (45%), Gaps = 5/101 (4%)
Query: 1091 TEEKKSQISADSGVSLTS-SSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1149
+E S S+DS S +S SS DS S S+S DS S+ SNSS +
Sbjct: 699 SESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDS 758
Query: 1150 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
+DS SS++ D S S SDS +NS+ S+
Sbjct: 759 SDSSNSSDSSDSSDSSDS----SDSSNSSDSNDSSNSSDSS 795
Score = 35.8 bits (81), Expect = 0.33
Identities = 33/132 (25%), Positives = 55/132 (41%), Gaps = 1/132 (0%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D +++ S S+DS S SS DS S + S S DS+ + S+S+
Sbjct: 589 DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSS 648
Query: 1147 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKL 1206
+SD SS++ + S + S + S S+ +S +S ++S + S
Sbjct: 649 DSSDNSD-SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDS 707
Query: 1207 AGSPIRTSEDVS 1218
+ S S D S
Sbjct: 708 SDSDSSDSSDSS 719
Score = 35.8 bits (81), Expect = 0.33
Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 1/104 (0%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D ++ + + S+DS S +S S + S S S S DS S+ S+SS
Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS 770
Query: 1147 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
+ +DS SSN+ D S + S + SDS ++S+ S+
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNS-SDSSNSSDSSDSS 813
Score = 35.4 bits (80), Expect = 0.44
Identities = 28/104 (26%), Positives = 45/104 (43%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D +++ S S+DS S S S ++ S S + SS DS S+ S+SS
Sbjct: 548 DSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDS 607
Query: 1147 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
+ +DS SS++ D SS ++NS+ S+
Sbjct: 608 SDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSS 651
Score = 35.4 bits (80), Expect = 0.44
Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 1/100 (1%)
Query: 1092 EEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGAD 1151
E S S+DS S S S + S S S S +S ++ S+SS + +D
Sbjct: 887 ESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSD 946
Query: 1152 SDLSSNAGDGPGGEGSVHLA-SSRGTLSDSEIETNSATST 1190
S SSN+ D S + + SS SDS +NS+ S+
Sbjct: 947 SSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS 986
Score = 35.4 bits (80), Expect = 0.44
Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 13/100 (13%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S+S DS S+ SNSS + +
Sbjct: 912 SDSSDSSNSSDSSESSNSSDNSNSSDS-----------SNSSDSSDSSDSSNSSDSSNSS 960
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SS++ D + S +S+ SDS ++S+ S+
Sbjct: 961 DSSNSSDSSDSNSSDSSD--SSNSSDSSDSSDSSDSSDSS 998
Score = 35.4 bits (80), Expect = 0.44
Identities = 32/101 (31%), Positives = 44/101 (43%), Gaps = 6/101 (5%)
Query: 1090 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1149
++ + S S+DS S SS DS S S S DS S+ SNSS +
Sbjct: 967 DSSDSNSSDSSDSSNSSDSSDSSDSSDS--SDSSDSSNSSDSSDSSDSSDSSNSSDSSNS 1024
Query: 1150 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
+DS SS++ D S S SDS +NS+ S+
Sbjct: 1025 SDSSNSSDSSDSSDSSDS----SDSSDSSDSSDSSNSSDSS 1061
Score = 35.0 bits (79), Expect = 0.57
Identities = 36/135 (26%), Positives = 55/135 (40%), Gaps = 16/135 (11%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S+S DS S+ S+SS + +
Sbjct: 735 SDSSNSSDSSDSSDSSNSSDSSDSSDS-----------SNSSDSSDSSDSSDSSDSSNSS 783
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGT-----LSDSEIETNSATSTIFGKAHSLKPSIKEK 1205
DS+ SSN+ D S ++S + SDS+ +S +S + S S
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD 843
Query: 1206 LAGSPIRTSEDVSQR 1220
+ S + D S R
Sbjct: 844 SSDSSDGSDSDSSNR 858
Score = 34.7 bits (78), Expect = 0.74
Identities = 32/104 (30%), Positives = 46/104 (44%), Gaps = 3/104 (2%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D ++ S S+DS S SS DS S S S DS S+ SNSS
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDS--SNSSDSSDSSDSSDSSNSSDSSNSSDS 1027
Query: 1147 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
+ +DS SS++ D S + S + SDS ++S+ S+
Sbjct: 1028 SNSSDSSDSSDSSDSSDSSDSSDSSDSSNS-SDSSDSSDSSDSS 1070
Score = 34.3 bits (77), Expect = 0.97
Identities = 29/105 (27%), Positives = 50/105 (47%), Gaps = 4/105 (3%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSG 1145
D +++ S S+DS S + SS +D DS + + SS S DS S+ S+S
Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624
Query: 1146 ETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
++ ++SD S + + + +S SDS +NS+ S+
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSN---SSDSSDNSDSSDSSNSSNSS 666
Score = 34.3 bits (77), Expect = 0.97
Identities = 31/106 (29%), Positives = 45/106 (42%), Gaps = 14/106 (13%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D ++ S ++DS S SS+ DS S S DS S+ SNSS
Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS-----------SDSSDSSSSSDSSNSSDS 689
Query: 1147 TLGADSDLS---SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1189
+ +DS S S++ D + S SS SDS+ +S +S
Sbjct: 690 SDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735
Score = 34.3 bits (77), Expect = 0.97
Identities = 31/104 (29%), Positives = 45/104 (43%), Gaps = 3/104 (2%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D ++ + S+DS S SS DS S + S+S DS S+ SNSS
Sbjct: 644 DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS--SDSSSSSDSSNSSDSSDSSDSSNSSES 701
Query: 1147 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
+ +DS S++ D S S SDS +NS+ S+
Sbjct: 702 SDSSDSS-DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744
Score = 34.3 bits (77), Expect = 0.97
Identities = 34/106 (32%), Positives = 49/106 (46%), Gaps = 8/106 (7%)
Query: 1091 TEEKKSQISADSGVSLTSS-----SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSG 1145
++ S S+DS S SS S +D DS S + SS DS S+ S+SS
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDS-SDSSNSNSSDSDSSNSSDSSDSSN 739
Query: 1146 ETLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATS 1189
+ +DS SSN+ D S + + S + SDS +NS+ S
Sbjct: 740 SSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785
Score = 33.9 bits (76), Expect = 1.3
Identities = 32/100 (32%), Positives = 43/100 (43%), Gaps = 5/100 (5%)
Query: 1090 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLG 1149
E++ S +DS S +S S S S S S DS S+ S+SS +
Sbjct: 630 ESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689
Query: 1150 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1189
+DS SSN+ E S SS SDS +NS +S
Sbjct: 690 SDSSDSSNSS-----ESSDSSDSSDSDSSDSSDSSNSNSS 724
Score = 33.9 bits (76), Expect = 1.3
Identities = 31/102 (30%), Positives = 45/102 (44%), Gaps = 13/102 (12%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS+ DS S S DS S+ S+SS + +
Sbjct: 1037 SDSSDSSDSSDSSDSSDSSNSSDSSDS-----------SDSSDSSDSSDSSDSSDSSESS 1085
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTL--SDSEIETNSATST 1190
DS SSN+ D S + S + SDS +NS+ S+
Sbjct: 1086 DSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1127
Score = 33.5 bits (75), Expect = 1.7
Identities = 31/108 (28%), Positives = 47/108 (43%), Gaps = 7/108 (6%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D ++ + S S+DS S SS DS + S DS + SNSS
Sbjct: 811 DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSS---DGSDSDSSNRSDSSNSSDS 867
Query: 1147 TLGADSDLSSNAGDGPGGEGSVHLA----SSRGTLSDSEIETNSATST 1190
+ +DS SS++ D S + + SS + SDS +NS+ S+
Sbjct: 868 SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915
Score = 33.5 bits (75), Expect = 1.7
Identities = 30/100 (30%), Positives = 46/100 (46%), Gaps = 12/100 (12%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S+S DS S+ SNSS + +
Sbjct: 989 SDSSDSSDSSDSSNSSDSSDSSDSSDS-----------SNSSDSSNSSDSSNSSDSSDSS 1037
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SS++ D S + + S + SDS ++S+ S+
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSDSS 1076
Score = 33.5 bits (75), Expect = 1.7
Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S S S DS S+ S+SS + +
Sbjct: 1088 SDSSNSSDSSDSSDSSDSSDSSDSSDS--SDSSDSSNSSDSSDSSDSSDSSDSSNSSDSS 1145
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SS++ D S + S + SDS +NS+ S+
Sbjct: 1146 DSSESSDSSDSSDSSDSSDSSDSSDS-SDSSDSSNSSDSS 1184
Score = 33.1 bits (74), Expect = 2.2
Identities = 27/100 (27%), Positives = 46/100 (46%), Gaps = 1/100 (1%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S S+ DS + + S S +S S+ SNSS + +
Sbjct: 868 SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
+S +SN+ D S + S + SDS ++S+ S+
Sbjct: 928 NSSDNSNSSDSSNSSDSSDSSDSSNS-SDSSNSSDSSNSS 966
Score = 32.7 bits (73), Expect = 2.8
Identities = 28/104 (26%), Positives = 48/104 (46%), Gaps = 9/104 (8%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D G+ + S + + + SS +D DS +SS DS+ S S+ S +
Sbjct: 541 DSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDS--------NSSSDSDSSDSDSSDSSD 592
Query: 1147 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDS-EIETNSATS 1189
+ +DS SS++ D S + S + SDS + E++S+ S
Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS 636
Score = 32.7 bits (73), Expect = 2.8
Identities = 28/101 (27%), Positives = 46/101 (45%), Gaps = 1/101 (0%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S +S S SS DS S S S +S S+ SNSS + +
Sbjct: 877 SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSS 936
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSE-IETNSATST 1190
DS SS++ D S ++S + + S+ ++NS+ S+
Sbjct: 937 DSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977
Score = 32.7 bits (73), Expect = 2.8
Identities = 26/99 (26%), Positives = 43/99 (43%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S++S S SS DS + SS +S S+ SNSS + +
Sbjct: 930 SDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSS 989
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1189
DS SS++ D S + S + + S+ +S +S
Sbjct: 990 DSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSS 1028
Score = 32.7 bits (73), Expect = 2.8
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 12/100 (12%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS+ DS S S DS S+ S+SS + +
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDS-----------SDSSDSSDSSDSSDSSDSSNSS 1058
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SS++ D S + S + SDS +NS+ S+
Sbjct: 1059 DSSDSSDSSDSSDSSDSSDSSDSSES-SDSSDSSNSSDSS 1097
Score = 32.7 bits (73), Expect = 2.8
Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S S S DS S+ S+SS + +
Sbjct: 1049 SDSSDSSNSSDSSDSSDSSDSSDSSDS--SDSSDSSESSDSSDSSNSSDSSDSSDSSDSS 1106
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SS++ D S + S + SDS +NS+ S+
Sbjct: 1107 DSSDSSDSSDSSDSSNSSDSSDSSDS-SDSSDSSNSSDSS 1145
Score = 32.7 bits (73), Expect = 2.8
Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S S S DS S+ S+SS + +
Sbjct: 1157 SDSSDSSDSSDSSDSSDSSDSSNSSDS--SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1214
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SS++ D S + S + SDS +NS+ S+
Sbjct: 1215 DSSDSSDSSDSSDSSDSNESSDSSDS-SDSSDSSNSSDSS 1253
Score = 32.3 bits (72), Expect = 3.7
Identities = 29/103 (28%), Positives = 47/103 (45%), Gaps = 3/103 (2%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSGETLG 1149
++ S S+DS S SS+ DS + + SS S DS+ S +S+ +
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSD 725
Query: 1150 ADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1190
+DS SS++ D S + S + SDS +NS+ S+
Sbjct: 726 SDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSS 768
Score = 32.3 bits (72), Expect = 3.7
Identities = 28/94 (29%), Positives = 40/94 (42%), Gaps = 11/94 (11%)
Query: 1096 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLS 1155
S S+DS S SS DS S+S DS S+ S+SS + +DS S
Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDS-----------SNSSDSSDSSDSSDSSDSSDSSDSSDS 1054
Query: 1156 SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1189
SN+ D S + S + S+ +S +S
Sbjct: 1055 SNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088
Score = 32.3 bits (72), Expect = 3.7
Identities = 31/100 (31%), Positives = 45/100 (45%), Gaps = 3/100 (3%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S S S DS S+ S+SS + +
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDS--SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1133
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SSN+ D S + S + SDS ++S+ S+
Sbjct: 1134 DSSDSSNSSDSSDSSESSDSSDSSDS-SDSSDSSDSSDSS 1172
Score = 32.3 bits (72), Expect = 3.7
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 6/100 (6%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S S DS S+ S+SS + +
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSES-----SDSSDSSDSSDSSDSSDSSDSS 1172
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SSN+ D S + S + SDS ++S+ S+
Sbjct: 1173 DSSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1211
Score = 32.3 bits (72), Expect = 3.7
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 9/100 (9%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S S+DS S SS DS S S DS S+ SNSS + +
Sbjct: 1136 SDSSNSSDSSDSSESSDSSDSSDSSDSSDS--------SDSSDSSDSSDSSNSSDSSDSS 1187
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DS SS++ D S + S + SDS ++S+ S+
Sbjct: 1188 DSSDSSDSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1226
Score = 32.0 bits (71), Expect = 4.8
Identities = 30/100 (30%), Positives = 44/100 (44%), Gaps = 12/100 (12%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
+ S S+DS S SSS +S S S DS S+ S SS + +
Sbjct: 660 SNSSNSSDSSDSSDSSDSSSSSDSSNS-----------SDSSDSSDSSNSSESSDSSDSS 708
Query: 1151 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1190
DSD SS++ D S +S+ SDS ++S+ S+
Sbjct: 709 DSD-SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Score = 32.0 bits (71), Expect = 4.8
Identities = 33/107 (30%), Positives = 47/107 (43%), Gaps = 4/107 (3%)
Query: 1087 DLGETEEKKSQISADSGVSLTSS-SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSG 1145
D ++ S S+DS S SS S + +S S S S DS S+ SNSS
Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSD 961
Query: 1146 ETLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1190
+ +DS SN+ D S + S + SDS +NS+ S+
Sbjct: 962 SSNSSDSS-DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSS 1007
Score = 32.0 bits (71), Expect = 4.8
Identities = 29/95 (30%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 1096 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-SQDSEVSTVVSNSSGETLGADSDL 1154
S S+DS S SS DS + SS S DS S+ S+SS + +DS
Sbjct: 1060 SSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSD 1119
Query: 1155 SSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1189
SSN+ D S + S + S+ +S +S
Sbjct: 1120 SSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154
Score = 31.6 bits (70), Expect = 6.3
Identities = 36/132 (27%), Positives = 54/132 (40%), Gaps = 3/132 (2%)
Query: 1087 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGE 1146
D + S S+DS S SS+ DS S S S DS S+ S+SS
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS--SDSNESSNSSDSSDSSNSSD-SDSSDS 908
Query: 1147 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKL 1206
+ +DS SSN+ D S ++S + + S+ +S +S ++S S
Sbjct: 909 SNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDS 968
Query: 1207 AGSPIRTSEDVS 1218
+ S S D S
Sbjct: 969 SDSNSSDSSDSS 980
Score = 31.2 bits (69), Expect = 8.2
Identities = 28/101 (27%), Positives = 42/101 (41%), Gaps = 2/101 (1%)
Query: 1091 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGA 1150
++ S +DS S S S + S S S S DS S+ S+SS + +
Sbjct: 842 SDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSS 901
Query: 1151 DSDLS--SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1189
DSD S SN+ D S + S + +S +S +S
Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSS 942
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
LC+LS+ P+F + + L TL L +E
Sbjct: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
Query: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
Query: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
Query: 417 PEPESLELKKHLKQ 430
P LK LK+
Sbjct: 284 PSDVVSALKNKLKK 297
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 51.2 bits (121), Expect = 8e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
++GV F +D M ++V LV+L
Sbjct: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 48.9 bits (115), Expect = 4e-05
Identities = 39/151 (25%), Positives = 69/151 (45%), Gaps = 8/151 (5%)
Query: 282 FALPDPSRFTLVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAF 339
F +PD + +L + VD L + +L E ++++ + L+ +
Sbjct: 155 FTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGS 214
Query: 340 VAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDL 399
AM+YP+ + IP+LP + AP PY+IG+ S + K+ DDV ++++
Sbjct: 215 AAMLYPMYWQHVYIPVLPPHLL---DYCCAPMPYLIGIHLS-LMEKVRNMALDDVVILNV 270
Query: 400 DSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
D+N + P + L LP LK LK+
Sbjct: 271 DTNTLETP--FDDLQSLPNDVISSLKNRLKK 299
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 62,343,839
Number of Sequences: 37866
Number of extensions: 3042349
Number of successful extensions: 14406
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 211
Number of HSP's that attempted gapping in prelim test: 12876
Number of HSP's gapped (non-prelim): 1151
length of query: 1565
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1449
effective length of database: 13,855,062
effective search space: 20075984838
effective search space used: 20075984838
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.