Guide to the Human Genome
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Search of human proteins with 209862785

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|209862785 anoctamin 2 [Homo sapiens]
         (998 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|209862785 anoctamin 2 [Homo sapiens]                              2022   0.0  
gi|194306539 anoctamin 1, calcium activated chloride channel [Ho...  1161   0.0  
gi|218084958 anoctamin 4 [Homo sapiens]                               681   0.0  
gi|156766084 transmembrane protein 16C [Homo sapiens]                 649   0.0  
gi|218081589 anoctamin 5 isoform b [Homo sapiens]                     623   e-178
gi|47106048 anoctamin 5 isoform a [Homo sapiens]                      623   e-178
gi|218156303 anoctamin 6 isoform b [Homo sapiens]                     561   e-160
gi|218156299 anoctamin 6 isoform a [Homo sapiens]                     561   e-160
gi|145207958 transmembrane protein 16G isoform NGEP long [Homo s...   548   e-156
gi|218156307 anoctamin 6 isoform c [Homo sapiens]                     546   e-155
gi|218156305 anoctamin 6 isoform c [Homo sapiens]                     546   e-155
gi|145611446 tumor protein p53 inducible protein 5 [Homo sapiens]     411   e-114
gi|94536803 transmembrane protein 16K [Homo sapiens]                  139   1e-32
gi|55741655 anoctamin 8 [Homo sapiens]                                102   2e-21
gi|239747244 PREDICTED: hypothetical protein [Homo sapiens]            92   2e-18
gi|169161033 PREDICTED: hypothetical protein [Homo sapiens]            84   7e-16
gi|239741065 PREDICTED: hypothetical protein [Homo sapiens]            78   5e-14
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ...    36   0.16 
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),...    36   0.16 
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),...    36   0.16 
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),...    36   0.16 
gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]        34   0.60 
gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]       33   1.0  
gi|197927147 B-cell lymphoma 6 protein isoform 2 [Homo sapiens]        33   1.0  
gi|119829187 alpha 1 type XVII collagen [Homo sapiens]                 33   1.0  
gi|57163987 solute carrier family 8 member 2 [Homo sapiens]            33   1.0  
gi|51479177 iroquois homeobox protein 1 [Homo sapiens]                 33   1.3  
gi|122939172 connexin 45 [Homo sapiens]                                33   1.3  
gi|69122473 connexin 45 [Homo sapiens]                                 33   1.3  
gi|56549696 E1A binding protein p400 [Homo sapiens]                    33   1.7  

>gi|209862785 anoctamin 2 [Homo sapiens]
          Length = 998

 Score = 2022 bits (5239), Expect = 0.0
 Identities = 998/998 (100%), Positives = 998/998 (100%)

Query: 1   MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGES 60
           MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGES
Sbjct: 1   MPEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCGGES 60

Query: 61  TRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLA 120
           TRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLA
Sbjct: 61  TRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLA 120

Query: 121 IVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS 180
           IVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS
Sbjct: 121 IVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGS 180

Query: 181 IFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHS 240
           IFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHS
Sbjct: 181 IFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHS 240

Query: 241 NNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIA 300
           NNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIA
Sbjct: 241 NNKMKNLSYPFSREKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIA 300

Query: 301 NNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFA 360
           NNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFA
Sbjct: 301 NNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFA 360

Query: 361 WLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSS 420
           WLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSS
Sbjct: 361 WLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSS 420

Query: 421 ACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEH 480
           ACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEH
Sbjct: 421 ACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEH 480

Query: 481 SRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFM 540
           SRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFM
Sbjct: 481 SRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFM 540

Query: 541 IALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAK 600
           IALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAK
Sbjct: 541 IALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAK 600

Query: 601 WLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRM 660
           WLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRM
Sbjct: 601 WLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRM 660

Query: 661 EECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSK 720
           EECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSK
Sbjct: 661 EECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSK 720

Query: 721 HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKF 780
           HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKF
Sbjct: 721 HPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKF 780

Query: 781 VTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLH 840
           VTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLH
Sbjct: 781 VTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLH 840

Query: 841 GFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA 900
           GFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA
Sbjct: 841 GFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSA 900

Query: 901 RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPA 960
           RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPA
Sbjct: 901 RLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMDEPA 960

Query: 961 LRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV 998
           LRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV
Sbjct: 961 LRSPGGGDRSRSRAASSAPSGQSQLGSMMSSGSQHTNV 998


>gi|194306539 anoctamin 1, calcium activated chloride channel [Homo
           sapiens]
          Length = 986

 Score = 1161 bits (3004), Expect = 0.0
 Identities = 563/894 (62%), Positives = 701/894 (78%), Gaps = 22/894 (2%)

Query: 86  MHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHA--GGPGDIELG- 142
           ++F D +RKVDY+L YH+++   +             S   + K+ H   G    ++ G 
Sbjct: 53  LYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGS 112

Query: 143 ---PLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFL 199
              P+D  E++++ +REE+E NL+EAGLELE+D + K  G  FV+IHAPW VL REAEFL
Sbjct: 113 GEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFL 172

Query: 200 KIKVPTKKMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLY 259
           K+K+PTKKMY I     + KK ++ LQK++  +QP+V EH    MK LSYPFSREK +L+
Sbjct: 173 KLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLF 232

Query: 260 NIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPE 319
           ++ +KD+FFD+ TRS IV+EILKRT C++A  +MGI SL+AN +Y AAYPLHDG+Y+   
Sbjct: 233 DLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGEN 292

Query: 320 DDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIV 379
            + NDRKLLY+EWARYGVFYK+QPIDL+RKYFGEKIGLYFAWLG+YT  LIP+S++G+IV
Sbjct: 293 VEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIV 352

Query: 380 FLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFF 439
           FLYGCAT++E+IPS EMCDQ++  TMCPLCDK+C YW +SSAC TA+ASHLFDNPATVFF
Sbjct: 353 FLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFF 412

Query: 440 SIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQ 499
           S+FMALWA  F+E+WKR QMRL Y WDLTG EEEEE  ++H R EYE +V EK LK+ ++
Sbjct: 413 SVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESR 472

Query: 500 SAVQ------------KLETNTTECGDE-DDEDKLTWKDRFPGYLMNFASILFMIALTFS 546
           +  +            K    T   G +  D+ KLTW+DRFP YL N  SI+FMIA+TF+
Sbjct: 473 NKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFA 532

Query: 547 IVFGVIVYRITTAAALSLNK--ATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTK 604
           IV GVI+YRI+ AAAL++N   + RSN+RVTVTATAVIINLVVI++LDE+YG +A+WLTK
Sbjct: 533 IVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTK 592

Query: 605 IEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECA 664
           IEVPKTE++FEERLI KAFLLKFVN+Y+PIFYVAFFKGRFVGRPG YVY+F  +RMEECA
Sbjct: 593 IEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECA 652

Query: 665 PGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQ 724
           PGGCLMELCIQLSIIMLGKQLIQNN+FEIG+PK+KKL R LK + ++        K  ++
Sbjct: 653 PGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQR 712

Query: 725 WDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTEL 784
           +++DY+LEP+ GLTPEYMEMIIQFGFVTLFVASFPLAP+FALLNN+IE+RLDAKKFVTEL
Sbjct: 713 YEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTEL 772

Query: 785 RRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVN 844
           RRP AVR KDIGIW++IL GIGK +VI NAFVI+ TSDFIPRLVY Y YS NGT+HGFVN
Sbjct: 773 RRPVAVRAKDIGIWYNILRGIGKLAVIINAFVISFTSDFIPRLVYLYMYSKNGTMHGFVN 832

Query: 845 HTLSFFNVSQLKEGTQPENS-QFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLA 903
           HTLS FNVS  + GT P +      EVQ CR+KDYREPPW+ N Y+ SK +W +L+ARLA
Sbjct: 833 HTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYREPPWSENKYDISKDFWAVLAARLA 892

Query: 904 FVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLKLMD 957
           FVI+FQNLVMF+S  VDW+IPDIP DIS QI KEK L+V+ F++EE +K +L++
Sbjct: 893 FVIVFQNLVMFMSDFVDWVIPDIPKDISQQIHKEKVLMVELFMREEQDKQQLLE 946


>gi|218084958 anoctamin 4 [Homo sapiens]
          Length = 920

 Score =  681 bits (1757), Expect = 0.0
 Identities = 357/829 (43%), Positives = 519/829 (62%), Gaps = 51/829 (6%)

Query: 153 EQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVP-TKKMYEI 211
           E+RE FE N+   GL++EK+    +   IFV++HAPW+VL R AE + +++P  +K+Y +
Sbjct: 98  EKREVFERNIRAEGLQMEKESSLINSDIIFVKLHAPWEVLGRYAEQMNVRMPFRRKIYYL 157

Query: 212 KAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNL------SYPFSREKMYLYNIQEKD 265
                   +    + +    L  +        + +L      + PFS+++++ + I  K+
Sbjct: 158 PRRYKFMSRIDKQISRFRRWLPKKPMRLDKETLPDLEENDCYTAPFSQQRIHHFIIHNKE 217

Query: 266 TFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDM--- 322
           TFF+NATRSRIVH IL+R       N +G+N L+ N  YEAA+PLH+G Y S        
Sbjct: 218 TFFNNATRSRIVHHILQRIKYEEGKNKIGLNRLLTNGSYEAAFPLHEGSYRSKNSIRTHG 277

Query: 323 --NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVF 380
             N R LLY+ WA +GV+YK+QP+DL+R+YFGEKIGLYFAWLG YT  L P++ IG+ VF
Sbjct: 278 AENHRHLLYECWASWGVWYKYQPLDLVRRYFGEKIGLYFAWLGWYTGMLFPAAFIGLFVF 337

Query: 381 LYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFS 440
           LYG  T++    S+E+C Q     MCP+CDK C +  LS +C  A+ +HLFDN ATVFF+
Sbjct: 338 LYGVTTLDHSQVSKEVC-QATDIIMCPVCDKYCPFMRLSDSCVYAKVTHLFDNGATVFFA 396

Query: 441 IFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQS 500
           +FMA+WAT+FLE WKR +  + Y WDL   EEEEE      RP++E K  +K        
Sbjct: 397 VFMAVWATVFLEFWKRRRAVIAYDWDLIDWEEEEEEI----RPQFEAKYSKKERMNPISG 452

Query: 501 AVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAA 560
             +  +  T +C                  +++ + I FMI +  + VFG+++YR+ T +
Sbjct: 453 KPEPYQAFTDKCSR---------------LIVSASGIFFMICVVIAAVFGIVIYRVVTVS 497

Query: 561 ALSLNK--ATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERL 618
             +  K    R+N +V  T TAV IN  +I++L+ +Y  VA  LT +E P+TE  +E   
Sbjct: 498 TFAAFKWALIRNNSQVATTGTAVCINFCIIMLLNVLYEKVALLLTNLEQPRTESEWENSF 557

Query: 619 ILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSI 678
            LK FL +FVN  S  FY+AFF GRF G PG+Y+ + + +R+EEC P GCL++LC+Q+ I
Sbjct: 558 TLKMFLFQFVNLNSSTFYIAFFLGRFTGHPGAYLRLINRWRLEECHPSGCLIDLCMQMGI 617

Query: 679 IMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYT--G 736
           IM+ KQ   NN  E+G P ++  + + K   E G           QW+ DY+L+P    G
Sbjct: 618 IMVLKQT-WNNFMELGYPLIQNWWTRRKVRQEHGPERKISFP---QWEKDYNLQPMNAYG 673

Query: 737 LTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIG 796
           L  EY+EMI+QFGF T+FVA+FPLAP+ ALLNN+IE+RLDA KFVT+ RRP A R KDIG
Sbjct: 674 LFDEYLEMILQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLASRAKDIG 733

Query: 797 IWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSY--------SHNGTLHGFVNHTLS 848
           IW+ IL GIG  SVI+NAFVIAITSDFIPRLVY Y Y        +    + G+VN +LS
Sbjct: 734 IWYGILEGIGILSVITNAFVIAITSDFIPRLVYAYKYGPCAGQGEAGQKCMVGYVNASLS 793

Query: 849 FFNVSQLKEGTQPEN--SQFD-QEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFV 905
            F +S  +  ++PE+  S+F    +++CR++DYR+PP +  PY ++ Q+W +L+ARLAF+
Sbjct: 794 VFRISDFENRSEPESDGSEFSGTPLKYCRYRDYRDPPHSLVPYGYTLQFWHVLAARLAFI 853

Query: 906 IIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLK 954
           I+F++LV  +  L+ ++IPD+P D+ D++++EK L+ +   + E E+L+
Sbjct: 854 IVFEHLVFCIKHLISYLIPDLPKDLRDRMRREKYLIQEMMYEAELERLQ 902


>gi|156766084 transmembrane protein 16C [Homo sapiens]
          Length = 981

 Score =  649 bits (1674), Expect = 0.0
 Identities = 356/826 (43%), Positives = 499/826 (60%), Gaps = 61/826 (7%)

Query: 153 EQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVP-TKKMYEI 211
           ++R  FE NL   GL LEK+    S   +F++IH PW  L + AE L I++P  KK Y  
Sbjct: 178 DKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYT 237

Query: 212 KAGGSIAKKFSAALQKLSSHL--QPRVPEHSN----NKMKNLSYPFSREKMYLYNIQEKD 265
                   +     +++ + +   P V + S      +    + PFSR +++ + I  KD
Sbjct: 238 DGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKD 297

Query: 266 TFFDNATRSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPED----- 320
           TFF NATRSRIV+ +L+RT      + +GI  LI N  Y AA+P H+G Y S +      
Sbjct: 298 TFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHG 357

Query: 321 DMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVF 380
             N+R LLY+ WAR+G++YK QP+DLIR YFGEKIGLYFAWLG YT  LIP++++G+ VF
Sbjct: 358 PQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVF 417

Query: 381 LYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFS 440
            YG  T+     S+E+C     F MCPLCDK+C    L+ +C  A+ ++LFDN  TVFF+
Sbjct: 418 FYGLFTMNNSQVSQEICKATEVF-MCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFA 476

Query: 441 IFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQS 500
           IFMA+WAT+FLE WKR +  L Y WDL   EEEEE      RP++E K            
Sbjct: 477 IFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETL----RPQFEAKY----------- 521

Query: 501 AVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAA 560
              K+E      G  +     +  D+    L++ + I FMI+L  + VFGV+VYR+    
Sbjct: 522 --YKMEIVNPITGKPEPHQPSS--DKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVME 577

Query: 561 ALSLNKAT--RSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERL 618
             +  K    +   +   +A AV IN ++I++L+  Y  +A  LT +E P+TE  +E   
Sbjct: 578 QFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSF 637

Query: 619 ILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSI 678
            LK FL +FVN  S IFY+AFF GRFVG PG Y  +FD +R+EEC P GCL++LC+Q+ +
Sbjct: 638 ALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGV 697

Query: 679 IMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYT--G 736
           IM  KQ I NN  E+G P ++  + + K +         H     QW+ D++L+P    G
Sbjct: 698 IMFLKQ-IWNNFMELGYPLIQNWWSRHKIKR------GIHDASIPQWENDWNLQPMNLHG 750

Query: 737 LTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIG 796
           L  EY+EM++QFGF T+FVA+FPLAP+ ALLNN+IE+RLDA KFVT+ RRP   R  DIG
Sbjct: 751 LMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIG 810

Query: 797 IWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS--------HNGTLHGFVNHTLS 848
           IW  IL GIG  +VI+NAFVIAITSD+IPR VY+Y Y             L G+VN++LS
Sbjct: 811 IWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLS 870

Query: 849 FFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIF 908
           FF++S+L  G          +  +CR++DYR PPW+  PYEF+ QYW IL+ARLAF+I+F
Sbjct: 871 FFDLSELGMG----------KSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVF 920

Query: 909 QNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLK 954
           ++LV  +   + ++IPD+P  + D+I++EK L+ +   + E E L+
Sbjct: 921 EHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQ 966


>gi|218081589 anoctamin 5 isoform b [Homo sapiens]
          Length = 912

 Score =  623 bits (1606), Expect = e-178
 Identities = 345/828 (41%), Positives = 499/828 (60%), Gaps = 59/828 (7%)

Query: 149 EERKEQREEFEHNLMEAGLELE-KDLENKSQG-SIFVRIHAPWQVLAREAEFLKIKVPTK 206
           E + E+R+EFE NL + GLELE +D  +   G + FV+IHAPW+VL   AE L IK+P K
Sbjct: 94  ELKAERRKEFETNLRKTGLELEIEDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIK 153

Query: 207 KMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDT 266
           +  +I         +     +L   ++   PE+        +  FSR +  L+ I+++ T
Sbjct: 154 ES-DIPRPKHTPISYVLGPVRLPLSVKYPHPEY-------FTAQFSRHRQELFLIEDQAT 205

Query: 267 FFDNATRSRIVHEILKRT--ACSRANNTMGINSLIANNIYEAAYPLHDGEY---DSPEDD 321
           FF +++R+RIV+ IL R            GI  L+ +N Y +AYPLHDG+Y     P + 
Sbjct: 206 FFPSSSRNRIVYYILSRCPFGIEDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNP 265

Query: 322 MNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFL 381
            N+R  L+Q WAR+  FYK QP+DLI+ Y+GEKIG+YF +LG YT  L  ++V+G+  F+
Sbjct: 266 TNERYTLHQNWARFSYFYKEQPLDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFI 325

Query: 382 YGCATIEEDIPSREMCDQQ--NAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFF 439
           YG  ++E +  S E+CD +      MCPLCD+ CDYW L+S C  ++ SHLFDN +TVFF
Sbjct: 326 YGLLSMEHNTSSTEICDPEIGGQMIMCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFF 385

Query: 440 SIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQ 499
           +IFM +W T+FLE WK+ Q RL Y WDL   EEE+++ Q   RPE+E      M K    
Sbjct: 386 AIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQ--LRPEFEA-----MCKHRKL 438

Query: 500 SAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRIT-- 557
           +AV K           + E  +    R P Y ++ A++   ++L  + +  VIVYR++  
Sbjct: 439 NAVTK-----------EMEPYMPLYTRIPWYFLSGATVTLWMSLVVTSMVAVIVYRLSVF 487

Query: 558 -TAAALSLNKATRSNVR------VTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKT 610
            T A+   + A+   V+      +T + T   +N +VILIL+  Y  ++ W+TK+E+P+T
Sbjct: 488 ATFASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYEKISAWITKMEIPRT 547

Query: 611 EQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLM 670
            Q +E  L LK FL +FVN YS  FYVAFFKG+FVG PG Y Y+F+ +R EEC PGGCL+
Sbjct: 548 YQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSEECDPGGCLI 607

Query: 671 ELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYS 730
           EL  QL+IIM GKQ+   NI E   P     +R+ K  T +        K   +W+ D+ 
Sbjct: 608 ELTTQLTIIMTGKQIF-GNIKEAIYPLALNWWRRRKARTNS-------EKLYSRWEQDHD 659

Query: 731 LEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPD 788
           LE +   GL  EY+E + QFGFVTLFVASFPLAP+ AL+NN++E+R+DA K  T+ RR  
Sbjct: 660 LESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTV 719

Query: 789 AVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGT--LHGFVNHT 846
           A +   IG+W DIL G+   SV +NAF++A TSD IPRLVY Y+YS N T  + G+VN++
Sbjct: 720 ASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYVNNS 779

Query: 847 LSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVI 906
           LS F ++     T P      ++   CR++DYR PP   N Y  + Q+W +L+A++ F+I
Sbjct: 780 LSVFLIADFPNHTAPSEK---RDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFII 836

Query: 907 IFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLK 954
           + +++V  +  L+ WMIPD+P D+ ++IK+EK + +      E  KLK
Sbjct: 837 VMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHDFELNKLK 884


>gi|47106048 anoctamin 5 isoform a [Homo sapiens]
          Length = 913

 Score =  623 bits (1606), Expect = e-178
 Identities = 345/828 (41%), Positives = 499/828 (60%), Gaps = 59/828 (7%)

Query: 149 EERKEQREEFEHNLMEAGLELE-KDLENKSQG-SIFVRIHAPWQVLAREAEFLKIKVPTK 206
           E + E+R+EFE NL + GLELE +D  +   G + FV+IHAPW+VL   AE L IK+P K
Sbjct: 95  ELKAERRKEFETNLRKTGLELEIEDKRDSEDGRTYFVKIHAPWEVLVTYAEVLGIKMPIK 154

Query: 207 KMYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQEKDT 266
           +  +I         +     +L   ++   PE+        +  FSR +  L+ I+++ T
Sbjct: 155 ES-DIPRPKHTPISYVLGPVRLPLSVKYPHPEY-------FTAQFSRHRQELFLIEDQAT 206

Query: 267 FFDNATRSRIVHEILKRT--ACSRANNTMGINSLIANNIYEAAYPLHDGEY---DSPEDD 321
           FF +++R+RIV+ IL R            GI  L+ +N Y +AYPLHDG+Y     P + 
Sbjct: 207 FFPSSSRNRIVYYILSRCPFGIEDGKKRFGIERLLNSNTYSSAYPLHDGQYWKPSEPPNP 266

Query: 322 MNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFL 381
            N+R  L+Q WAR+  FYK QP+DLI+ Y+GEKIG+YF +LG YT  L  ++V+G+  F+
Sbjct: 267 TNERYTLHQNWARFSYFYKEQPLDLIKNYYGEKIGIYFVFLGFYTEMLFFAAVVGLACFI 326

Query: 382 YGCATIEEDIPSREMCDQQ--NAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFF 439
           YG  ++E +  S E+CD +      MCPLCD+ CDYW L+S C  ++ SHLFDN +TVFF
Sbjct: 327 YGLLSMEHNTSSTEICDPEIGGQMIMCPLCDQVCDYWRLNSTCLASKFSHLFDNESTVFF 386

Query: 440 SIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQ 499
           +IFM +W T+FLE WK+ Q RL Y WDL   EEE+++ Q   RPE+E      M K    
Sbjct: 387 AIFMGIWVTLFLEFWKQRQARLEYEWDLVDFEEEQQQLQ--LRPEFEA-----MCKHRKL 439

Query: 500 SAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRIT-- 557
           +AV K           + E  +    R P Y ++ A++   ++L  + +  VIVYR++  
Sbjct: 440 NAVTK-----------EMEPYMPLYTRIPWYFLSGATVTLWMSLVVTSMVAVIVYRLSVF 488

Query: 558 -TAAALSLNKATRSNVR------VTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPKT 610
            T A+   + A+   V+      +T + T   +N +VILIL+  Y  ++ W+TK+E+P+T
Sbjct: 489 ATFASFMESDASLKQVKSFLTPQITTSLTGSCLNFIVILILNFFYEKISAWITKMEIPRT 548

Query: 611 EQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLM 670
            Q +E  L LK FL +FVN YS  FYVAFFKG+FVG PG Y Y+F+ +R EEC PGGCL+
Sbjct: 549 YQEYESSLTLKMFLFQFVNFYSSCFYVAFFKGKFVGYPGKYTYLFNEWRSEECDPGGCLI 608

Query: 671 ELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYS 730
           EL  QL+IIM GKQ+   NI E   P     +R+ K  T +        K   +W+ D+ 
Sbjct: 609 ELTTQLTIIMTGKQIF-GNIKEAIYPLALNWWRRRKARTNS-------EKLYSRWEQDHD 660

Query: 731 LEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPD 788
           LE +   GL  EY+E + QFGFVTLFVASFPLAP+ AL+NN++E+R+DA K  T+ RR  
Sbjct: 661 LESFGPLGLFYEYLETVTQFGFVTLFVASFPLAPLLALINNIVEIRVDAWKLTTQYRRTV 720

Query: 789 AVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGT--LHGFVNHT 846
           A +   IG+W DIL G+   SV +NAF++A TSD IPRLVY Y+YS N T  + G+VN++
Sbjct: 721 ASKAHSIGVWQDILYGMAVLSVATNAFIVAFTSDIIPRLVYYYAYSTNATQPMTGYVNNS 780

Query: 847 LSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVI 906
           LS F ++     T P      ++   CR++DYR PP   N Y  + Q+W +L+A++ F+I
Sbjct: 781 LSVFLIADFPNHTAPSEK---RDFITCRYRDYRYPPDDENKYFHNMQFWHVLAAKMTFII 837

Query: 907 IFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEKLK 954
           + +++V  +  L+ WMIPD+P D+ ++IK+EK + +      E  KLK
Sbjct: 838 VMEHVVFLVKFLLAWMIPDVPKDVVERIKREKLMTIKILHDFELNKLK 885


>gi|218156303 anoctamin 6 isoform b [Homo sapiens]
          Length = 892

 Score =  561 bits (1447), Expect = e-160
 Identities = 331/895 (36%), Positives = 488/895 (54%), Gaps = 98/895 (10%)

Query: 86  MHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLD 145
           + F+D QR++D+VL Y    R                   ET K+               
Sbjct: 42  LFFNDGQRRIDFVLVYEDESRK------------------ETNKK--------------- 68

Query: 146 ALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPT 205
              E+++ +R+ +E NL+  GL+LE          +FV++HAPW+VL   AE + IK+P 
Sbjct: 69  GTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 128

Query: 206 KK--MYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQE 263
           K   +    +       F+  L    S ++P        + +  + PF + +M  + I +
Sbjct: 129 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKP--------EQEFFTAPFEKNRMNDFYIVD 180

Query: 264 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPEDD 321
           +D FF+ ATRSRIV+ IL R      NN    GIN L+ + IY+AA+PLHD ++    +D
Sbjct: 181 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 240

Query: 322 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 378
               N+R LLY+EWA     YK QP+DLIRKY+GEKIG+YFAWLG YT  L+ ++V+GV 
Sbjct: 241 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 300

Query: 379 VFLYGCATIEEDIPSREMC--DQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPAT 436
            FLYG    +    S+E+C  D      MCP CD+ C +W L+  C +++   +FD+  T
Sbjct: 301 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 360

Query: 437 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKE 496
           + F++FM +W T+FLE WKR Q  L Y WD   +++EE+     +RPEYE +    ++ E
Sbjct: 361 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQ-----ARPEYEARCTHVVINE 415

Query: 497 SNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRI 556
             Q               E++    T   +     +  +++ F I L  + V G+IVYR+
Sbjct: 416 ITQ---------------EEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 460

Query: 557 TTAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIE 606
           +     S       N           +   + TA II+ ++I+IL+ IY  VA  +T  E
Sbjct: 461 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 520

Query: 607 VPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPG 666
           +P+T+  +E  L +K FL +FVN YS  FY+AFFKG+FVG PG  VY    YR EEC PG
Sbjct: 521 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 580

Query: 667 GCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWD 726
           GCL+EL  QL+IIM GK  I NNI E+ +P +  L  +           S   K   +W+
Sbjct: 581 GCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRF-------HRVSGSEKITPRWE 632

Query: 727 LDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTEL 784
            DY L+P    GL  EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K  T+ 
Sbjct: 633 QDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQF 692

Query: 785 RRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS------HNG- 837
           RR    + +DIG W  I+ GI   +V++NA +IA TSD IPRLVY +S+S      H   
Sbjct: 693 RRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSY 752

Query: 838 TLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFI 897
           T+ G++N+TLS F V+  K  ++            CR++D+R PP  P  Y+ +  YW +
Sbjct: 753 TMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHV 812

Query: 898 LSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK 952
           ++A+LAF+I+ ++++  +   + + IPD+      +I++EK  L    L E H K
Sbjct: 813 IAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHENHLK 866


>gi|218156299 anoctamin 6 isoform a [Homo sapiens]
          Length = 910

 Score =  561 bits (1447), Expect = e-160
 Identities = 331/895 (36%), Positives = 488/895 (54%), Gaps = 98/895 (10%)

Query: 86  MHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLD 145
           + F+D QR++D+VL Y    R                   ET K+               
Sbjct: 60  LFFNDGQRRIDFVLVYEDESRK------------------ETNKK--------------- 86

Query: 146 ALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPT 205
              E+++ +R+ +E NL+  GL+LE          +FV++HAPW+VL   AE + IK+P 
Sbjct: 87  GTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146

Query: 206 KK--MYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQE 263
           K   +    +       F+  L    S ++P        + +  + PF + +M  + I +
Sbjct: 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKP--------EQEFFTAPFEKNRMNDFYIVD 198

Query: 264 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPEDD 321
           +D FF+ ATRSRIV+ IL R      NN    GIN L+ + IY+AA+PLHD ++    +D
Sbjct: 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258

Query: 322 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 378
               N+R LLY+EWA     YK QP+DLIRKY+GEKIG+YFAWLG YT  L+ ++V+GV 
Sbjct: 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318

Query: 379 VFLYGCATIEEDIPSREMC--DQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPAT 436
            FLYG    +    S+E+C  D      MCP CD+ C +W L+  C +++   +FD+  T
Sbjct: 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378

Query: 437 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKE 496
           + F++FM +W T+FLE WKR Q  L Y WD   +++EE+     +RPEYE +    ++ E
Sbjct: 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQ-----ARPEYEARCTHVVINE 433

Query: 497 SNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRI 556
             Q               E++    T   +     +  +++ F I L  + V G+IVYR+
Sbjct: 434 ITQ---------------EEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478

Query: 557 TTAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIE 606
           +     S       N           +   + TA II+ ++I+IL+ IY  VA  +T  E
Sbjct: 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538

Query: 607 VPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPG 666
           +P+T+  +E  L +K FL +FVN YS  FY+AFFKG+FVG PG  VY    YR EEC PG
Sbjct: 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598

Query: 667 GCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWD 726
           GCL+EL  QL+IIM GK  I NNI E+ +P +  L  +           S   K   +W+
Sbjct: 599 GCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRF-------HRVSGSEKITPRWE 650

Query: 727 LDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTEL 784
            DY L+P    GL  EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K  T+ 
Sbjct: 651 QDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQF 710

Query: 785 RRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS------HNG- 837
           RR    + +DIG W  I+ GI   +V++NA +IA TSD IPRLVY +S+S      H   
Sbjct: 711 RRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSY 770

Query: 838 TLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFI 897
           T+ G++N+TLS F V+  K  ++            CR++D+R PP  P  Y+ +  YW +
Sbjct: 771 TMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHV 830

Query: 898 LSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKKEKSLLVDFFLKEEHEK 952
           ++A+LAF+I+ ++++  +   + + IPD+      +I++EK  L    L E H K
Sbjct: 831 IAAKLAFIIVMEHVIYSVKFFISYAIPDVSKRTKSKIQREK-YLTQKLLHENHLK 884


>gi|145207958 transmembrane protein 16G isoform NGEP long [Homo
           sapiens]
          Length = 933

 Score =  548 bits (1412), Expect = e-156
 Identities = 314/793 (39%), Positives = 472/793 (59%), Gaps = 57/793 (7%)

Query: 155 REEFEHNLMEAGLELEK-DLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPTKKMYEIKA 213
           RE F  NL  AGL +++ D+++ +    +  + A W VL   AE L++K+P +++    +
Sbjct: 141 RETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLCYYAEDLRLKLPLQELPNQAS 200

Query: 214 GGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLY-NIQEKDTFFDNAT 272
             S        +  +   + P VP       +  S  F   K+  +     +DTFF +  
Sbjct: 201 NWSAGLLAWLGIPNVLLEVVPDVPP------EYYSCRFRVNKLPRFLGSDNQDTFFTSTK 254

Query: 273 RSRIVHEILKRTACSRAN-NTMGINSLIANNIYEAAYPLHDGEYDSPEDD-----MNDRK 326
           R +I+ EIL +T       N +GI+ L+A  +  AA+PLHDG + +P +      +N R+
Sbjct: 255 RHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQ 314

Query: 327 LLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCAT 386
           +L+Q WAR+G + K+QP+D +R+YFGEK+ LYFAWLG YT +L+P++V+G +VFL GC  
Sbjct: 315 VLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFL 374

Query: 387 IEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALW 446
           +  DIP++E+C  +++F MCPLC   C +W LSSAC  AQA  LFD+  TVFFS+FMALW
Sbjct: 375 VFSDIPTQELCGSKDSFEMCPLC-LDCPFWLLSSACALAQAGRLFDHGGTVFFSLFMALW 433

Query: 447 ATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAVQKLE 506
           A + LE WKR    L Y WD +  E+ EER     RP++              SA     
Sbjct: 434 AVLLLEYWKRKSATLAYRWDCSDYEDTEERP----RPQFAA------------SAPMTAP 477

Query: 507 TNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNK 566
              T     +DE     + R    L     I+ M+A+    +  +I+YR   A  +S + 
Sbjct: 478 NPITG----EDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSG 533

Query: 567 ATRSNVRVTVTA--TAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFL 624
            T      +  A  T  ++NLV ILIL +IY ++A  LT+ E+ +T+  FE+   LK F+
Sbjct: 534 NTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFI 593

Query: 625 LKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQ 684
            +FVN YS   Y+AFFKGRFVG PG+Y  +F G R EECA GGCL+EL  +L +IM+GKQ
Sbjct: 594 FQFVNFYSSPVYIAFFKGRFVGYPGNYHTLF-GVRNEECAAGGCLIELAQELLVIMVGKQ 652

Query: 685 LIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEM 744
           +I NN+ E+ +PKLK  ++K +  ++  +  ++       W+ DY L P  GL  EY+EM
Sbjct: 653 VI-NNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEM 711

Query: 745 IIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSG 804
           ++QFGFVT+FVA+ PLAP+FALLNN +E+RLDA+KFV E RRP A R +DIGIWF IL+G
Sbjct: 712 VLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAG 771

Query: 805 IGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFNVSQLKEGTQPENS 864
           +   +VISNAF++A +SDF+PR  Y+++ +H+  L GF+N TL+           +  +S
Sbjct: 772 LTHLAVISNAFLLAFSSDFLPRAYYRWTRAHD--LRGFLNFTLA-----------RAPSS 818

Query: 865 QFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIP 924
                 + CR++ +R+     +   +S+ YW +L+ RLAFVI+F+++V  +  L+D ++P
Sbjct: 819 FAAAHNRTCRYRAFRD-----DDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVP 873

Query: 925 DIPTDISDQIKKE 937
           DIP  +  ++K+E
Sbjct: 874 DIPESVEIKVKRE 886


>gi|218156307 anoctamin 6 isoform c [Homo sapiens]
          Length = 929

 Score =  546 bits (1406), Expect = e-155
 Identities = 321/856 (37%), Positives = 469/856 (54%), Gaps = 97/856 (11%)

Query: 86  MHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLD 145
           + F+D QR++D+VL Y    R                   ET K+               
Sbjct: 60  LFFNDGQRRIDFVLVYEDESRK------------------ETNKK--------------- 86

Query: 146 ALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPT 205
              E+++ +R+ +E NL+  GL+LE          +FV++HAPW+VL   AE + IK+P 
Sbjct: 87  GTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146

Query: 206 KK--MYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQE 263
           K   +    +       F+  L    S ++P        + +  + PF + +M  + I +
Sbjct: 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKP--------EQEFFTAPFEKNRMNDFYIVD 198

Query: 264 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPEDD 321
           +D FF+ ATRSRIV+ IL R      NN    GIN L+ + IY+AA+PLHD ++    +D
Sbjct: 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258

Query: 322 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 378
               N+R LLY+EWA     YK QP+DLIRKY+GEKIG+YFAWLG YT  L+ ++V+GV 
Sbjct: 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318

Query: 379 VFLYGCATIEEDIPSREMC--DQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPAT 436
            FLYG    +    S+E+C  D      MCP CD+ C +W L+  C +++   +FD+  T
Sbjct: 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378

Query: 437 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKE 496
           + F++FM +W T+FLE WKR Q  L Y WD   +++EE+     +RPEYE +    ++ E
Sbjct: 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQ-----ARPEYEARCTHVVINE 433

Query: 497 SNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRI 556
             Q               E++    T   +     +  +++ F I L  + V G+IVYR+
Sbjct: 434 ITQ---------------EEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478

Query: 557 TTAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIE 606
           +     S       N           +   + TA II+ ++I+IL+ IY  VA  +T  E
Sbjct: 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538

Query: 607 VPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPG 666
           +P+T+  +E  L +K FL +FVN YS  FY+AFFKG+FVG PG  VY    YR EEC PG
Sbjct: 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598

Query: 667 GCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWD 726
           GCL+EL  QL+IIM GK  I NNI E+ +P +  L  +           S   K   +W+
Sbjct: 599 GCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRF-------HRVSGSEKITPRWE 650

Query: 727 LDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTEL 784
            DY L+P    GL  EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K  T+ 
Sbjct: 651 QDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQF 710

Query: 785 RRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS------HNG- 837
           RR    + +DIG W  I+ GI   +V++NA +IA TSD IPRLVY +S+S      H   
Sbjct: 711 RRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSY 770

Query: 838 TLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFI 897
           T+ G++N+TLS F V+  K  ++            CR++D+R PP  P  Y+ +  YW +
Sbjct: 771 TMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHV 830

Query: 898 LSARLAFVIIFQNLVM 913
           ++A+LAF+I+ + L +
Sbjct: 831 IAAKLAFIIVMEYLAL 846


>gi|218156305 anoctamin 6 isoform c [Homo sapiens]
          Length = 929

 Score =  546 bits (1406), Expect = e-155
 Identities = 321/856 (37%), Positives = 469/856 (54%), Gaps = 97/856 (11%)

Query: 86  MHFHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGPGDIELGPLD 145
           + F+D QR++D+VL Y    R                   ET K+               
Sbjct: 60  LFFNDGQRRIDFVLVYEDESRK------------------ETNKK--------------- 86

Query: 146 ALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKIKVPT 205
              E+++ +R+ +E NL+  GL+LE          +FV++HAPW+VL   AE + IK+P 
Sbjct: 87  GTNEKQRRKRQAYESNLICHGLQLEATRSVLDDKLVFVKVHAPWEVLCTYAEIMHIKLPL 146

Query: 206 KK--MYEIKAGGSIAKKFSAALQKLSSHLQPRVPEHSNNKMKNLSYPFSREKMYLYNIQE 263
           K   +    +       F+  L    S ++P        + +  + PF + +M  + I +
Sbjct: 147 KPNDLKNRSSAFGTLNWFTKVLSVDESIIKP--------EQEFFTAPFEKNRMNDFYIVD 198

Query: 264 KDTFFDNATRSRIVHEILKRTACSRANNT--MGINSLIANNIYEAAYPLHDGEYDSPEDD 321
           +D FF+ ATRSRIV+ IL R      NN    GIN L+ + IY+AA+PLHD ++    +D
Sbjct: 199 RDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGIYKAAFPLHDCKFRRQSED 258

Query: 322 M---NDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVI 378
               N+R LLY+EWA     YK QP+DLIRKY+GEKIG+YFAWLG YT  L+ ++V+GV 
Sbjct: 259 PSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFAWLGYYTQMLLLAAVVGVA 318

Query: 379 VFLYGCATIEEDIPSREMC--DQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPAT 436
            FLYG    +    S+E+C  D      MCP CD+ C +W L+  C +++   +FD+  T
Sbjct: 319 CFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKLNITCESSKKLCIFDSFGT 378

Query: 437 VFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKE 496
           + F++FM +W T+FLE WKR Q  L Y WD   +++EE+     +RPEYE +    ++ E
Sbjct: 379 LVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQ-----ARPEYEARCTHVVINE 433

Query: 497 SNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRI 556
             Q               E++    T   +     +  +++ F I L  + V G+IVYR+
Sbjct: 434 ITQ---------------EEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRL 478

Query: 557 TTAAALSLNKATRSN----------VRVTVTATAVIINLVVILILDEIYGAVAKWLTKIE 606
           +     S       N           +   + TA II+ ++I+IL+ IY  VA  +T  E
Sbjct: 479 SVFIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFE 538

Query: 607 VPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPG 666
           +P+T+  +E  L +K FL +FVN YS  FY+AFFKG+FVG PG  VY    YR EEC PG
Sbjct: 539 LPRTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPG 598

Query: 667 GCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQWD 726
           GCL+EL  QL+IIM GK  I NNI E+ +P +  L  +           S   K   +W+
Sbjct: 599 GCLLELTTQLTIIMGGKA-IWNNIQEVLLPWIMNLIGRF-------HRVSGSEKITPRWE 650

Query: 727 LDYSLEPY--TGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTEL 784
            DY L+P    GL  EY+EMIIQFGFVTLFVASFPLAP+ AL+NN++E+R+DA K  T+ 
Sbjct: 651 QDYHLQPMGKLGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQF 710

Query: 785 RRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYS------HNG- 837
           RR    + +DIG W  I+ GI   +V++NA +IA TSD IPRLVY +S+S      H   
Sbjct: 711 RRLVPEKAQDIGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSY 770

Query: 838 TLHGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFI 897
           T+ G++N+TLS F V+  K  ++            CR++D+R PP  P  Y+ +  YW +
Sbjct: 771 TMEGYINNTLSIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHV 830

Query: 898 LSARLAFVIIFQNLVM 913
           ++A+LAF+I+ + L +
Sbjct: 831 IAAKLAFIIVMEYLAL 846


>gi|145611446 tumor protein p53 inducible protein 5 [Homo sapiens]
          Length = 782

 Score =  411 bits (1057), Expect = e-114
 Identities = 252/683 (36%), Positives = 372/683 (54%), Gaps = 79/683 (11%)

Query: 273 RSRIVHEILKRTACSRANNTMGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEW 332
           R RIV+ ++     S          L+ + ++EA +PLH GE             L + W
Sbjct: 119 RIRIVNFVVMNNKTSAGET---FEDLMKDGVFEARFPLHKGE-----------GRLKKTW 164

Query: 333 ARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIP 392
           AR+   ++ QP+D IR YFGEK+ LYF WLG YT  L+P+++ G++VFL G +  E    
Sbjct: 165 ARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQI 224

Query: 393 SREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLE 452
           S+E+C+  +   MCPL D S  Y  LS  C  A+ +HLFDN  TV F+IFMALWAT+FLE
Sbjct: 225 SKEICEAHDIL-MCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLE 283

Query: 453 NWKRLQMRLGYFWDLTGIEEEEERA--QEHSRPEYETKVREKMLKESNQSAVQKLETNTT 510
            WKR + R+   WDL   +EE+E    Q  + P+Y+ +  +     S    V        
Sbjct: 284 IWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILV-------- 335

Query: 511 ECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVFGVIVYRITTAAALSLNKATRS 570
                     LT               L MI L   +   ++VYR+  +A  S +     
Sbjct: 336 ----------LT---------------LLMICLMIGMAHVLVVYRVLASALFSSSAVPFL 370

Query: 571 NVRVT--VTATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFV 628
             +VT  V  T  +++ V I+I+ +I   VA  L   E+P+T    E R  ++ F L+F 
Sbjct: 371 EEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFF 430

Query: 629 NAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQN 688
             +S + Y+AF  GR  G PG    +   +++EEC   GC+M+L +Q++IIM  KQ + N
Sbjct: 431 THFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSN 490

Query: 689 NIFEIGVPKLKKLFRKLKDETEAGETDSAH-SKHPE--QWDLDYSLEPYT--GLTPEYME 743
            + E  VP +    R L+       ++S H  + PE   W  +Y L P     L  E+ME
Sbjct: 491 CV-EYLVPWVTHKCRSLR------ASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFME 543

Query: 744 MIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILS 803
           M+IQ+GF T+FVA+FPLAP+ AL +N++E+RLDA K V   RR    + KDIG W  +L 
Sbjct: 544 MMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLE 603

Query: 804 GIGKFSVISNAFVIAITSDFIPRLVYQYSYS-----HNGT---LHGFVNHTLSFFNVSQL 855
            IG  +VI+N  VIA TS+FIPR+VY+Y YS      N T   L G+VNH+LS F+    
Sbjct: 604 TIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHT--- 660

Query: 856 KEGTQPENSQFDQEVQFCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFL 915
           K+   P+  +  + V  CR++DYR PP     Y FS+Q+WF+L+ RLAFVI+F+++ + +
Sbjct: 661 KDFQDPDGIEGSENVTLCRYRDYRNPP----DYNFSEQFWFLLAIRLAFVILFEHVALCI 716

Query: 916 SVLVDWMIPDIPTDISDQIKKEK 938
            ++  W +PDIP  + +++ + K
Sbjct: 717 KLIAAWFVPDIPQSVKNKVLEVK 739


>gi|94536803 transmembrane protein 16K [Homo sapiens]
          Length = 660

 Score =  139 bits (350), Expect = 1e-32
 Identities = 132/529 (24%), Positives = 219/529 (41%), Gaps = 112/529 (21%)

Query: 295 INSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEW-ARYGVFYKFQPIDLIRKYFGE 353
           +  L+ + I    +PLHD E           K L   W  R+ +  K+QPID IR YFGE
Sbjct: 158 LRRLLTSGIVIQVFPLHDSEA---------LKKLEDTWYTRFAL--KYQPIDSIRGYFGE 206

Query: 354 KIGLYFAWLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSC 413
            I LYF +L  +T  LIP +VIG+  +L+                               
Sbjct: 207 TIALYFGFLEYFTFALIPMAVIGLPYYLF------------------------------- 235

Query: 414 DYWNLSSACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEE 473
             W               D    V F+ F  +W+T+ LE WKR    + Y W    ++  
Sbjct: 236 -VWE--------------DYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLMK-- 278

Query: 474 EERAQEHSRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMN 533
             R  E  RP +   +    +    +                      ++K +   YL+ 
Sbjct: 279 --RKFEEPRPGFHGVLGINSITGKEEPLYP------------------SYKRQLRIYLV- 317

Query: 534 FASILFMIALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDE 593
             S+ F+    +  ++ +++Y      AL L++ + S     +     II  +VI I++ 
Sbjct: 318 --SLPFVCLCLYFSLYVMMIYFDMEVWALGLHENSGSEWTSVLLYVPSIIYAIVIEIMNR 375

Query: 594 IYGAVAKWLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVY 653
           +Y   A++LT  E  + E  ++  LILK  +  F+N ++ +FY+AF              
Sbjct: 376 LYRYAAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKD---------- 425

Query: 654 VFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKL--KKLFRKLKDETEA 711
                           M+L  Q    +L    I N I E  +P    +K   ++K + +A
Sbjct: 426 ----------------MKLLRQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQA 469

Query: 712 GETDSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVI 771
            + D   + + EQ  L+  +  Y G   +Y+E+ +QFG+V+LF   +PLA  FA+LNN  
Sbjct: 470 LKADIDATLY-EQVILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFT 528

Query: 772 EVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAIT 820
           EV  DA K     +RP +  + +IG+W      +   SV++N  +I ++
Sbjct: 529 EVNSDALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMS 577


>gi|55741655 anoctamin 8 [Homo sapiens]
          Length = 1232

 Score =  102 bits (253), Expect = 2e-21
 Identities = 94/400 (23%), Positives = 158/400 (39%), Gaps = 92/400 (23%)

Query: 251 FSREKMYLY-NIQEKDTFFDNATRSRIVHEILKRTACSRANNTMGIN---------SLIA 300
           FS E+ ++Y N++ +  FF +  R  I+   L+     +      +           L A
Sbjct: 142 FSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAA 201

Query: 301 NNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFA 360
             I +  +P+H       E  + +R  L + W +     + QP+D I  YFG KI +YFA
Sbjct: 202 RGIIQQVFPVH-------EQRILNR--LMKSWVQ--AVCENQPLDDICDYFGVKIAMYFA 250

Query: 361 WLGLYTSFLIPSSVIGVIVFLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSS 420
           WLG YTS ++  +V G +++ +     E D  SR               D SC       
Sbjct: 251 WLGFYTSAMVYPAVFGSVLYTF----TEADQTSR---------------DVSC------- 284

Query: 421 ACGTAQASHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEH 480
                           V F++F  +W+T+FLE WKR    L Y W   G  +    A E 
Sbjct: 285 ----------------VVFALFNVIWSTLFLEEWKRRGAELAYKW---GTLDSPGEAVEE 325

Query: 481 SRPEYETKVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFM 540
            RP++    R   +  + +                       WK      L++    L  
Sbjct: 326 PRPQFRGVRRISPITRAEEFYYP------------------PWKRLLFQLLVSLPLCLAC 367

Query: 541 IALTFSIVFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAK 600
           +   F ++ G    +    +   L +  R   +V +         +++ +  E Y  +A 
Sbjct: 368 LVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLA--------LLVSVSAEGYKKLAI 419

Query: 601 WLTKIEVPKTEQTFEERLILKAFLLKFVNAYSPIFYVAFF 640
           WL  +E  + E  +E+ LI+K  L +FVN+Y  +FY+ F+
Sbjct: 420 WLNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFY 459



 Score = 83.6 bits (205), Expect = 9e-16
 Identities = 39/103 (37%), Positives = 63/103 (61%)

Query: 715 DSAHSKHPEQWDLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVR 774
           +  HS    Q +L+  ++ Y     +Y EM +QFG+V LF ++FPLA + AL+NN+IE+R
Sbjct: 722 EEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEIR 781

Query: 775 LDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVI 817
            DA K  T L+RP   R + IG W  ++  +G  +++ N ++I
Sbjct: 782 SDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLI 824


>gi|239747244 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 719

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 127/512 (24%), Positives = 203/512 (39%), Gaps = 118/512 (23%)

Query: 428 SHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYET 487
           S LFD+P TVFFSIFM+ W        +     L + WD +  +++E  A   S P +  
Sbjct: 256 SCLFDHPGTVFFSIFMSFWGHGLPGALEAGSATLAHHWDCSDFQDQE--AMPSSAPHHWD 313

Query: 488 KVREKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSI 547
                     +Q  +     +  +C D  D+++           + FA++   + +T + 
Sbjct: 314 -----CSDFQDQEVMPSSALHHWDCSDFQDQEECPH--------LQFAALA--LQMTQNP 358

Query: 548 VFGVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEV 607
           V G+        + LS      S+  +      V+I LV ++I   I  ++A + T   V
Sbjct: 359 VTGLKEPYFQPHSCLS--HLLTSSAAILTVLCVVMIFLVSVIIYHGII-SIAMFHTGNSV 415

Query: 608 PKTEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGG 667
             T+                 +A   +  ++F   +F+     +  +  G    +C PGG
Sbjct: 416 LMTQAN--------VLWGNGGDASMKMPSLSFSVCQFL-----FFSLLHGILQRQCGPGG 462

Query: 668 CLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQW-D 726
           C +++  QL IIM+GKQL+                                  H E++  
Sbjct: 463 CHIQVTQQLIIIMVGKQLLN---------------------------------HMEEFVG 489

Query: 727 LDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRR 786
           L     P T   PE     +QFGF+T+FV +F LAP+F LLNN +E+ LDA KF+ + +R
Sbjct: 490 LGGGPGPDTPCLPE-----LQFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHKFLCKYQR 544

Query: 787 PDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHT 846
           P A R    G            S      +I   ++   RL     Y  NG         
Sbjct: 545 PMAGRGWTSG---------SDCSCWRPCELILPRTNARSRL----GYWLNGQ-------- 583

Query: 847 LSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNP-YEFSKQ--------YWFI 897
                  Q+    +  N+ F  E+        REP   P P Y+ S+         YW +
Sbjct: 584 ------GQILGRRRGGNAGFGVEI--------REPLQTPQPRYKASRDVGVNLALFYWKL 629

Query: 898 LS--ARLAFVIIFQNLVMFLSVLVDWMIPDIP 927
           L+    L F+I F+N+V F     D ++PD+P
Sbjct: 630 LAVHVHLGFIIAFENVVFFFLCPNDRLVPDVP 661



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 26/70 (37%), Positives = 38/70 (54%), Gaps = 9/70 (12%)

Query: 277 VHEILKRTACSRANNT-MGINSLIANNIYEAAYPLHDGEYDSPEDDMNDRKLLYQEWARY 335
           V EIL RT   +  +T MGI  L+   ++E         Y  P  D+N  +LLY  WA +
Sbjct: 188 VAEILDRTISRKKKHTEMGIAHLLG--LFELP------GYQVPGSDLNSCQLLYPYWACW 239

Query: 336 GVFYKFQPID 345
           G ++K+QP+D
Sbjct: 240 GYWHKYQPLD 249


>gi|169161033 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 723

 Score = 84.0 bits (206), Expect = 7e-16
 Identities = 124/510 (24%), Positives = 199/510 (39%), Gaps = 118/510 (23%)

Query: 430 LFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKV 489
           L D   TVFFSIFM+ W        +     L + WD +  +++E  A   S P +    
Sbjct: 262 LGDGLGTVFFSIFMSFWGHGLPGALEAGSATLAHHWDCSDFQDQE--AMPSSAPHHWD-- 317

Query: 490 REKMLKESNQSAVQKLETNTTECGDEDDEDKLTWKDRFPGYLMNFASILFMIALTFSIVF 549
                   +Q  +     +  +C D  D+++           + FA++   + +T + V 
Sbjct: 318 ---CSDFQDQEVMPSSALHHWDCSDFQDQEECPH--------LQFAALA--LQMTQNPVT 364

Query: 550 GVIVYRITTAAALSLNKATRSNVRVTVTATAVIINLVVILILDEIYGAVAKWLTKIEVPK 609
           G+        + LS      S+  +      V+I LV ++I   I  ++A + T   V  
Sbjct: 365 GLKEPYFQPHSCLS--HLLTSSAAILTVLCVVMIFLVSVIIYHGII-SIAMFHTGNSVLM 421

Query: 610 TEQTFEERLILKAFLLKFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCL 669
           T+                 +A   +  ++F   +F+     +  +  G    +C PGGC 
Sbjct: 422 TQAN--------VLWGNGGDASMKMPSLSFSVCQFL-----FFSLLHGILQRQCGPGGCH 468

Query: 670 MELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSKHPEQW-DLD 728
           +++  QL IIM+GKQL+                                  H E++  L 
Sbjct: 469 IQVTQQLIIIMVGKQLLN---------------------------------HMEEFVGLG 495

Query: 729 YSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPD 788
               P T   PE     +QFGF+T+FV +F LAP+F LLNN +E+ LDA KF+ + +RP 
Sbjct: 496 GGPGPDTPCLPE-----LQFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHKFLCKYQRPM 550

Query: 789 AVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLS 848
           A R    G            S      +I   ++   RL     Y  NG           
Sbjct: 551 AGRGWTSG---------SDCSCWRPCELILPRTNARSRL----GYWLNGQ---------- 587

Query: 849 FFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNP-YEFSKQ--------YWFILS 899
                Q+    +  N+ F  E+        REP   P P Y+ S+         YW +L+
Sbjct: 588 ----GQILGRRRGGNAGFGVEI--------REPLQTPQPRYKASRDVGVNLALFYWKLLA 635

Query: 900 --ARLAFVIIFQNLVMFLSVLVDWMIPDIP 927
               L F+I F+N+V F     D ++PD+P
Sbjct: 636 VHVHLGFIIAFENVVFFFLCPNDRLVPDVP 665


>gi|239741065 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 494

 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 80/279 (28%), Positives = 116/279 (41%), Gaps = 85/279 (30%)

Query: 661 EECAPGGCLMELCIQLSIIMLGKQLIQNNIFEIGVPKLKKLFRKLKDETEAGETDSAHSK 720
           ++C PGGC +++  QL IIM+GKQL+                                  
Sbjct: 231 QQCGPGGCHIQVTQQLIIIMVGKQLLN--------------------------------- 257

Query: 721 HPEQW-DLDYSLEPYTGLTPEYMEMIIQFGFVTLFVASFPLAPVFALLNNVIEVRLDAKK 779
           H E++  L     P T   PE     +QFGF+T+FV +F LAP+F LLNN +E+ LDA K
Sbjct: 258 HMEEFVGLGGGPGPDTPCLPE-----LQFGFITIFVGAFLLAPLFTLLNNRVEIGLDAHK 312

Query: 780 FVTELRRPDAVRTKDIGIWFDILSGIGKFSVISNAFVIAITSDFIPRLVYQYSYSHNGTL 839
           F+ + +RP A R    G            S      +I   ++   RL     Y  NG  
Sbjct: 313 FLCKYQRPMAGRGWTSG---------SDCSCWRPCELILPRTNARSRL----GYWLNGQ- 358

Query: 840 HGFVNHTLSFFNVSQLKEGTQPENSQFDQEVQFCRFKDYREPPWAPNP-YEFSKQ----- 893
                         Q+    +  N+ F  E+        REP   P P Y+ S+      
Sbjct: 359 -------------GQILGRRRGGNAGFGVEI--------REPLQTPQPRYKASRDVGVNL 397

Query: 894 ---YWFILS--ARLAFVIIFQNLVMFLSVLVDWMIPDIP 927
              YW +L+    L F+I F+N+V F     D ++PD+P
Sbjct: 398 ALFYWKLLAVHVHLGFIIAFENVVFFFLCPNDRLVPDVP 436



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 21/58 (36%), Positives = 30/58 (51%), Gaps = 2/58 (3%)

Query: 428 SHLFDNPATVFFSIFMALWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEY 485
           S LFD+P TVFFSIFM+ W        +     L + WD +  +++E  A   S P +
Sbjct: 52  SCLFDHPGTVFFSIFMSFWGHGLPGALEAGSATLAHHWDCSDFQDQE--AMPSSAPHH 107



 Score = 37.0 bits (84), Expect = 0.093
 Identities = 14/31 (45%), Positives = 21/31 (67%)

Query: 315 YDSPEDDMNDRKLLYQEWARYGVFYKFQPID 345
           Y  P  D+N  +LLY  WA +G ++K+QP+D
Sbjct: 15  YQVPGSDLNSCQLLYPYWACWGYWHKYQPLD 45


>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform A [Homo sapiens]
          Length = 973

 Score = 36.2 bits (82), Expect = 0.16
 Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 27/105 (25%)

Query: 467 LTGIEEEEERAQEHSRP--------------EYETK-VREKMLKESNQSAV--------Q 503
           LT  EEEE R  E  RP               YE K   +K++K++N + V        Q
Sbjct: 688 LTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQ 747

Query: 504 KLETNTTECGDEDDEDKLTWKDRFPG---YLMNFASILFMIALTF 545
            +E  T   G++DD+D+   +++ P    Y+M+F ++ + +   F
Sbjct: 748 FIEAITVSAGEDDDDDE-CGEEKLPSCFDYVMHFLTVFWKVLFAF 791


>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform D [Homo sapiens]
          Length = 937

 Score = 36.2 bits (82), Expect = 0.16
 Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 27/105 (25%)

Query: 467 LTGIEEEEERAQEHSRP--------------EYETK-VREKMLKESNQSAV--------Q 503
           LT  EEEE R  E  RP               YE K   +K++K++N + V        Q
Sbjct: 652 LTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQ 711

Query: 504 KLETNTTECGDEDDEDKLTWKDRFPG---YLMNFASILFMIALTF 545
            +E  T   G++DD+D+   +++ P    Y+M+F ++ + +   F
Sbjct: 712 FIEAITVSAGEDDDDDE-CGEEKLPSCFDYVMHFLTVFWKVLFAF 755


>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform C [Homo sapiens]
          Length = 960

 Score = 36.2 bits (82), Expect = 0.16
 Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 27/105 (25%)

Query: 467 LTGIEEEEERAQEHSRP--------------EYETK-VREKMLKESNQSAV--------Q 503
           LT  EEEE R  E  RP               YE K   +K++K++N + V        Q
Sbjct: 675 LTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQ 734

Query: 504 KLETNTTECGDEDDEDKLTWKDRFPG---YLMNFASILFMIALTF 545
            +E  T   G++DD+D+   +++ P    Y+M+F ++ + +   F
Sbjct: 735 FIEAITVSAGEDDDDDE-CGEEKLPSCFDYVMHFLTVFWKVLFAF 778


>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
           member 1 isoform B [Homo sapiens]
          Length = 968

 Score = 36.2 bits (82), Expect = 0.16
 Identities = 29/105 (27%), Positives = 49/105 (46%), Gaps = 27/105 (25%)

Query: 467 LTGIEEEEERAQEHSRP--------------EYETK-VREKMLKESNQSAV--------Q 503
           LT  EEEE R  E  RP               YE K   +K++K++N + V        Q
Sbjct: 683 LTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQ 742

Query: 504 KLETNTTECGDEDDEDKLTWKDRFPG---YLMNFASILFMIALTF 545
            +E  T   G++DD+D+   +++ P    Y+M+F ++ + +   F
Sbjct: 743 FIEAITVSAGEDDDDDE-CGEEKLPSCFDYVMHFLTVFWKVLFAF 786


>gi|151108509 Rho GTPase-activating protein RICH2 [Homo sapiens]
          Length = 818

 Score = 34.3 bits (77), Expect = 0.60
 Identities = 21/77 (27%), Positives = 30/77 (38%), Gaps = 7/77 (9%)

Query: 2   PEDIPLLPGSPR-------RLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQ 54
           P  + L PG  R        LSP +  +G  G   G  C        PG Q G++  P Q
Sbjct: 575 PSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQ 634

Query: 55  PCGGESTRSSSVINNYL 71
           P   +S  +   ++  L
Sbjct: 635 PPADQSPHTLRKVSKKL 651


>gi|89363017 alpha 2 type V collagen preproprotein [Homo sapiens]
          Length = 1499

 Score = 33.5 bits (75), Expect = 1.0
 Identities = 21/54 (38%), Positives = 26/54 (48%), Gaps = 1/54 (1%)

Query: 2   PEDIPLLPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQP 55
           P  +P++ G   R  P AG  G QGP+  +     PGPR P    G    PGQP
Sbjct: 118 PGLVPVVTGIRGRPGP-AGPPGSQGPRGERGPKGRPGPRGPQGIDGEPGVPGQP 170



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 18/47 (38%), Positives = 20/47 (42%)

Query: 9   PGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQP 55
           P  P      AG RG QGP        +PGP  P  +GG   D G P
Sbjct: 652 PSGPVGPPGLAGERGEQGPPGPTGFQGLPGPPGPPGEGGKPGDQGVP 698


>gi|197927147 B-cell lymphoma 6 protein isoform 2 [Homo sapiens]
          Length = 650

 Score = 33.5 bits (75), Expect = 1.0
 Identities = 25/99 (25%), Positives = 39/99 (39%), Gaps = 13/99 (13%)

Query: 8   LPGSPRRLS----------PQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQPCG 57
           + GSPR  S          P+  S G Q P+H + CL   GP  P   G +  +      
Sbjct: 454 MTGSPRSSSESHSPLYMHPPKCTSCGSQSPQHAEMCLHTAGPTFPEEMGETQSEYSDSSC 513

Query: 58  GESTRSSSVINNYLDANEPVSLEARLSRMHFHDSQRKVD 96
           GE     ++       N P +L+   +R+H  +   K +
Sbjct: 514 GEKPYRCNICG--AQFNRPANLKTH-TRIHSGEKPYKCE 549


>gi|119829187 alpha 1 type XVII collagen [Homo sapiens]
          Length = 1497

 Score = 33.5 bits (75), Expect = 1.0
 Identities = 20/47 (42%), Positives = 25/47 (53%), Gaps = 4/47 (8%)

Query: 9   PGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQP 55
           PG+   + P AG  G QGP+  Q    MPG R P    G + DPG+P
Sbjct: 736 PGAKGAMGP-AGPDGHQGPRGEQGLTGMPGIRGP---PGPSGDPGKP 778


>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
          Length = 921

 Score = 33.5 bits (75), Expect = 1.0
 Identities = 26/101 (25%), Positives = 45/101 (44%), Gaps = 26/101 (25%)

Query: 467 LTGIEEEEERAQEHSRPEYETKVR---------------EKMLKESNQSAV--------Q 503
           LT  EEE  R  E  +P      R               +K++K++N + V        Q
Sbjct: 635 LTAEEEEARRIAEMGKPVLGENCRLEVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQ 694

Query: 504 KLETNTTECGDEDDEDKLTWKDRFPG---YLMNFASILFMI 541
            LE  T   GDE++E+  + ++R P    Y+M+F ++ + +
Sbjct: 695 FLEAITVSAGDEEEEEDGSREERLPSCFDYVMHFLTVFWKV 735


>gi|51479177 iroquois homeobox protein 1 [Homo sapiens]
          Length = 480

 Score = 33.1 bits (74), Expect = 1.3
 Identities = 22/63 (34%), Positives = 26/63 (41%), Gaps = 7/63 (11%)

Query: 2   PEDIPL-------LPGSPRRLSPQAGSRGGQGPKHGQQCLKMPGPRAPGLQGGSNRDPGQ 54
           P+D PL        PGS R LSP A + G QG  HG+  +      A    G     P  
Sbjct: 277 PQDSPLGLAKEAPEPGSTRLLSPGAAAGGLQGAPHGKPKIWSLAETATSPDGAPKASPPP 336

Query: 55  PCG 57
           P G
Sbjct: 337 PAG 339


>gi|122939172 connexin 45 [Homo sapiens]
          Length = 396

 Score = 33.1 bits (74), Expect = 1.3
 Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 3/66 (4%)

Query: 113 GFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKD 172
           G+  H +A + +GE  K+     P  +      ALEE  ++  E+    +M   +ELE D
Sbjct: 93  GYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEED---PMMYPEMELESD 149

Query: 173 LENKSQ 178
            ENK Q
Sbjct: 150 KENKEQ 155


>gi|69122473 connexin 45 [Homo sapiens]
          Length = 396

 Score = 33.1 bits (74), Expect = 1.3
 Identities = 21/66 (31%), Positives = 32/66 (48%), Gaps = 3/66 (4%)

Query: 113 GFPGHSLAIVSNGETGKEPHAGGPGDIELGPLDALEEERKEQREEFEHNLMEAGLELEKD 172
           G+  H +A + +GE  K+     P  +      ALEE  ++  E+    +M   +ELE D
Sbjct: 93  GYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEED---PMMYPEMELESD 149

Query: 173 LENKSQ 178
            ENK Q
Sbjct: 150 KENKEQ 155


>gi|56549696 E1A binding protein p400 [Homo sapiens]
          Length = 3122

 Score = 32.7 bits (73), Expect = 1.7
 Identities = 24/67 (35%), Positives = 34/67 (50%), Gaps = 1/67 (1%)

Query: 169  LEKDLENKSQGSIFVRIHAPWQVLAREAEFL-KIKVPTKKMYEIKAGGSIAKKFSAALQK 227
            LE+D   ++  S+F  I    ++   EAE L K K+P K M EI    + A + +AA  K
Sbjct: 1363 LERDFWKEADLSMFDLIGLENKITRHEAELLSKKKIPRKLMEEISTSAAPAARPAAAKLK 1422

Query: 228  LSSHLQP 234
             S   QP
Sbjct: 1423 ASRLFQP 1429


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,085,680
Number of Sequences: 37866
Number of extensions: 1873659
Number of successful extensions: 8437
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 28
Number of HSP's successfully gapped in prelim test: 47
Number of HSP's that attempted gapping in prelim test: 8096
Number of HSP's gapped (non-prelim): 299
length of query: 998
length of database: 18,247,518
effective HSP length: 112
effective length of query: 886
effective length of database: 14,006,526
effective search space: 12409782036
effective search space used: 12409782036
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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