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Search of human proteins with 209571517
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|209571517 MAP-kinase activating death domain-containing
protein isoform h [Homo sapiens]
(1587 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|209571517 MAP-kinase activating death domain-containing prote... 3164 0.0
gi|209862971 MAP-kinase activating death domain-containing prote... 3160 0.0
gi|209862983 MAP-kinase activating death domain-containing prote... 3148 0.0
gi|209862994 MAP-kinase activating death domain-containing prote... 3121 0.0
gi|209862998 MAP-kinase activating death domain-containing prote... 3051 0.0
gi|209862979 MAP-kinase activating death domain-containing prote... 3046 0.0
gi|209863002 MAP-kinase activating death domain-containing prote... 3041 0.0
gi|209862975 MAP-kinase activating death domain-containing prote... 3034 0.0
gi|18860873 MAP-kinase activating death domain-containing protei... 2974 0.0
gi|209862987 MAP-kinase activating death domain-containing prote... 2899 0.0
gi|239735519 SET binding factor 1 [Homo sapiens] 103 1e-21
gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo sapi... 90 2e-17
gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo sapi... 90 2e-17
gi|148922920 DENN/MADD domain containing 4B [Homo sapiens] 84 1e-15
gi|94818781 DENN/MADD domain containing 4C [Homo sapiens] 77 1e-13
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 77 1e-13
gi|29788755 SET binding factor 2 [Homo sapiens] 77 2e-13
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 72 3e-12
gi|50345870 DENN/MADD domain containing 3 [Homo sapiens] 72 3e-12
gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 62 6e-09
gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapi... 62 6e-09
gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo sapi... 62 6e-09
gi|121949817 DENN/MADD domain containing 2C [Homo sapiens] 59 5e-08
gi|154813195 DENN/MADD domain containing 2A [Homo sapiens] 58 6e-08
gi|113205087 DENN/MADD domain containing 1C [Homo sapiens] 58 6e-08
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 56 2e-07
gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo sapi... 56 3e-07
gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo sapi... 52 3e-06
gi|21361991 DENN/MADD domain containing 2D [Homo sapiens] 51 8e-06
gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens] 49 4e-05
>gi|209571517 MAP-kinase activating death domain-containing protein
isoform h [Homo sapiens]
Length = 1587
Score = 3164 bits (8204), Expect = 0.0
Identities = 1587/1587 (100%), Positives = 1587/1587 (100%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
Query: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
Query: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
Query: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
Query: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
Query: 1141 VIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS 1200
VIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS
Sbjct: 1141 VIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS 1200
Query: 1201 DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ 1260
DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ
Sbjct: 1201 DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ 1260
Query: 1261 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1320
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1261 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1320
Query: 1321 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1380
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1321 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1380
Query: 1381 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1440
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1381 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1440
Query: 1441 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1500
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1441 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1500
Query: 1501 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1560
VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1501 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1560
Query: 1561 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1561 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
>gi|209862971 MAP-kinase activating death domain-containing protein
isoform a [Homo sapiens]
Length = 1588
Score = 3160 bits (8192), Expect = 0.0
Identities = 1587/1588 (99%), Positives = 1587/1588 (99%), Gaps = 1/1588 (0%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
Query: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
Query: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
Query: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
Query: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
Query: 1141 VIGVSPAVMIRSSSQDSEVST-VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1199
VIGVSPAVMIRSSSQDSEVST VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL
Sbjct: 1141 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1200
Query: 1200 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1259
SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD
Sbjct: 1201 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1260
Query: 1260 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1319
QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI
Sbjct: 1261 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1320
Query: 1320 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1379
SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK
Sbjct: 1321 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1380
Query: 1380 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1439
KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR
Sbjct: 1381 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1440
Query: 1440 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1499
RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL
Sbjct: 1441 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1500
Query: 1500 QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY 1559
QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY
Sbjct: 1501 QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY 1560
Query: 1560 SVLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
SVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1561 SVLCLFSYVAAVHSSEEDLRTPPRPVSS 1588
>gi|209862983 MAP-kinase activating death domain-containing protein
isoform e [Homo sapiens]
Length = 1608
Score = 3148 bits (8161), Expect = 0.0
Identities = 1587/1608 (98%), Positives = 1587/1608 (98%), Gaps = 21/1608 (1%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 884
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 885 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 940
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 941 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1000
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 1001 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1060
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1061 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1120
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1140
Query: 1121 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST-VSNSSGETLGADSDLSSN 1179
ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST VSNSSGETLGADSDLSSN
Sbjct: 1141 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1200
Query: 1180 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1239
AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV
Sbjct: 1201 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1260
Query: 1240 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1299
SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD
Sbjct: 1261 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1320
Query: 1300 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1359
RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ
Sbjct: 1321 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1380
Query: 1360 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1419
LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW
Sbjct: 1381 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1440
Query: 1420 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1479
YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG
Sbjct: 1441 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1500
Query: 1480 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1539
PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP
Sbjct: 1501 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1560
Query: 1540 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1561 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1608
>gi|209862994 MAP-kinase activating death domain-containing protein
isoform d [Homo sapiens]
Length = 1647
Score = 3121 bits (8092), Expect = 0.0
Identities = 1586/1647 (96%), Positives = 1586/1647 (96%), Gaps = 60/1647 (3%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 884
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 885 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 940
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 941 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1000
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 1001 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1060
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1061 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1102
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
Query: 1103 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST- 1161
EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
Query: 1162 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1221
VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
Query: 1222 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1260
PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG KERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
Query: 1261 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1320
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
Query: 1321 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1380
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
Query: 1381 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1440
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
Query: 1441 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1500
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
Query: 1501 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1560
VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1561 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1620
Query: 1561 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1621 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1647
>gi|209862998 MAP-kinase activating death domain-containing protein
isoform i [Homo sapiens]
Length = 1544
Score = 3051 bits (7910), Expect = 0.0
Identities = 1544/1587 (97%), Positives = 1544/1587 (97%), Gaps = 43/1587 (2%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857
Query: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 858 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917
Query: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 918 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977
Query: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 978 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037
Query: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097
Query: 1141 VIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS 1200
VIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS
Sbjct: 1098 VIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS 1157
Query: 1201 DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ 1260
DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ
Sbjct: 1158 DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ 1217
Query: 1261 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1320
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1218 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1277
Query: 1321 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1380
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1278 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1337
Query: 1381 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1440
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1338 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1397
Query: 1441 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1500
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1398 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1457
Query: 1501 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1560
VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1458 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1517
Query: 1561 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1518 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1544
>gi|209862979 MAP-kinase activating death domain-containing protein
isoform c [Homo sapiens]
Length = 1545
Score = 3046 bits (7898), Expect = 0.0
Identities = 1544/1588 (97%), Positives = 1544/1588 (97%), Gaps = 44/1588 (2%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857
Query: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 858 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917
Query: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 918 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977
Query: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 978 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037
Query: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097
Query: 1141 VIGVSPAVMIRSSSQDSEVSTV-SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1199
VIGVSPAVMIRSSSQDSEVSTV SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL
Sbjct: 1098 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1157
Query: 1200 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1259
SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD
Sbjct: 1158 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1217
Query: 1260 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1319
QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI
Sbjct: 1218 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1277
Query: 1320 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1379
SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK
Sbjct: 1278 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1337
Query: 1380 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1439
KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR
Sbjct: 1338 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1397
Query: 1440 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1499
RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL
Sbjct: 1398 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1457
Query: 1500 QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY 1559
QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY
Sbjct: 1458 QVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICY 1517
Query: 1560 SVLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
SVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1518 SVLCLFSYVAAVHSSEEDLRTPPRPVSS 1545
>gi|209863002 MAP-kinase activating death domain-containing protein
isoform j [Homo sapiens]
Length = 1541
Score = 3041 bits (7883), Expect = 0.0
Identities = 1541/1587 (97%), Positives = 1541/1587 (97%), Gaps = 46/1587 (2%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857
Query: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 858 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917
Query: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 918 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977
Query: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 978 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037
Query: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097
Query: 1141 VIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS 1200
VIGVSPAVMIRSSSQDSEVS NSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS
Sbjct: 1098 VIGVSPAVMIRSSSQDSEVS---NSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLS 1154
Query: 1201 DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ 1260
DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ
Sbjct: 1155 DSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWDQ 1214
Query: 1261 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1320
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1215 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1274
Query: 1321 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1380
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1275 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1334
Query: 1381 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1440
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1335 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1394
Query: 1441 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1500
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1395 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1454
Query: 1501 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1560
VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS
Sbjct: 1455 VTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVPEIKEVVSHKYKTPMAHEICYS 1514
Query: 1561 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
VLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1515 VLCLFSYVAAVHSSEEDLRTPPRPVSS 1541
>gi|209862975 MAP-kinase activating death domain-containing protein
isoform b [Homo sapiens]
Length = 1565
Score = 3034 bits (7867), Expect = 0.0
Identities = 1544/1608 (96%), Positives = 1544/1608 (96%), Gaps = 64/1608 (3%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 884
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 857
Query: 885 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 940
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 858 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 917
Query: 941 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1000
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 918 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 977
Query: 1001 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1060
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 978 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1037
Query: 1061 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1120
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ
Sbjct: 1038 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQ 1097
Query: 1121 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV-SNSSGETLGADSDLSSN 1179
ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV SNSSGETLGADSDLSSN
Sbjct: 1098 ISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSN 1157
Query: 1180 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1239
AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV
Sbjct: 1158 AGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDV 1217
Query: 1240 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1299
SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD
Sbjct: 1218 SQRVYLYEGLLGKERSTLWDQMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHD 1277
Query: 1300 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1359
RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ
Sbjct: 1278 RKRLEDDEDRLLATLLHNLISYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQ 1337
Query: 1360 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1419
LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW
Sbjct: 1338 LANLNGRDLSIWSSGSRHMKKQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWW 1397
Query: 1420 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1479
YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG
Sbjct: 1398 YEKLINMTYCPKTKVLCLWRRNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPG 1457
Query: 1480 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1539
PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP
Sbjct: 1458 PELGGEFPVQDLKTGEGGLLQVTLEGINLKFMHNQVFIELNHIKKCNTVRGVFVLEEFVP 1517
Query: 1540 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1587
EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS
Sbjct: 1518 EIKEVVSHKYKTPMAHEICYSVLCLFSYVAAVHSSEEDLRTPPRPVSS 1565
>gi|18860873 MAP-kinase activating death domain-containing protein
isoform g [Homo sapiens]
Length = 1581
Score = 2974 bits (7710), Expect = 0.0
Identities = 1515/1579 (95%), Positives = 1517/1579 (96%), Gaps = 61/1579 (3%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK---------------- 884
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK
Sbjct: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKVFGLNTLMEIVTEAGP 900
Query: 885 ----GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 940
GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW
Sbjct: 901 GSGEGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGW 960
Query: 941 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1000
LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL
Sbjct: 961 LNMKKVRRLLESEQLRVFVLSKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVL 1020
Query: 1001 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1060
SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP
Sbjct: 1021 SLEQSYAHAGLGGMASIFGLLEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDP 1080
Query: 1061 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI------------------GP 1102
KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASI P
Sbjct: 1081 KAMAQLRVPQLGPRAPSATGKGPKELDTRSLKEENFIASIELWNKHQEVKKQKALEKQRP 1140
Query: 1103 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST- 1161
EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVST
Sbjct: 1141 EVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTV 1200
Query: 1162 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1221
VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK
Sbjct: 1201 VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLK 1260
Query: 1222 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG---------------------KERSTLWDQ 1260
PSIKEKLAGSPIRTSEDVSQRVYLYEGLLG KERSTLWDQ
Sbjct: 1261 PSIKEKLAGSPIRTSEDVSQRVYLYEGLLGRDKGSMWDQLEDAAMETFSISKERSTLWDQ 1320
Query: 1261 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1320
MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS
Sbjct: 1321 MQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLIS 1380
Query: 1321 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1380
YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK
Sbjct: 1381 YMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMKK 1440
Query: 1381 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1440
QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR
Sbjct: 1441 QTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWRR 1500
Query: 1441 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1500
NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ
Sbjct: 1501 NGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLLQ 1560
Query: 1501 VTLEGINLKFMHNQVFIEL 1519
VTLEGINLKFMHNQ F++L
Sbjct: 1561 VTLEGINLKFMHNQ-FLKL 1578
>gi|209862987 MAP-kinase activating death domain-containing protein
isoform f [Homo sapiens]
Length = 1479
Score = 2899 bits (7516), Expect = 0.0
Identities = 1473/1520 (96%), Positives = 1475/1520 (97%), Gaps = 45/1520 (2%)
Query: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG
Sbjct: 1 MVQKKKFCPRLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEG 60
Query: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE
Sbjct: 61 CLSVRQRRMSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKE 120
Query: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL
Sbjct: 121 GTHATCASEEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVL 180
Query: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL
Sbjct: 181 SHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSAL 240
Query: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP
Sbjct: 241 LHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLP 300
Query: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM
Sbjct: 301 LELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCM 360
Query: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE
Sbjct: 361 ASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPE 420
Query: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN
Sbjct: 421 SLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGN 480
Query: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE
Sbjct: 481 DVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASRPRQTPFAE 540
Query: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ
Sbjct: 541 KLARTQAVEYFGEWILNPTNYAFQRIHNNMFDPALIGDKPKWYAHQLQPIHYRVYDSNSQ 600
Query: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL
Sbjct: 601 LAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPL 660
Query: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE
Sbjct: 661 THAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSE 720
Query: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFP 780
PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG
Sbjct: 721 PADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEG------------------- 761
Query: 781 PEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 840
AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST
Sbjct: 762 ------------------------AQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTST 797
Query: 841 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 900
EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH
Sbjct: 798 EGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKH 857
Query: 901 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 960
SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL
Sbjct: 858 SPTVKREPPSPQGRSSNSSENQQFLKEVVHSVLDGQGVGWLNMKKVRRLLESEQLRVFVL 917
Query: 961 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 1020
SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL
Sbjct: 918 SKLNRMVQSEDDARQDIIPDVEISRKVYKGMLDLLKCTVLSLEQSYAHAGLGGMASIFGL 977
Query: 1021 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1080
LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG
Sbjct: 978 LEIAQTHYYSKEPDKRKRSPTESVNTPVGKDPGLAGRGDPKAMAQLRVPQLGPRAPSATG 1037
Query: 1081 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1140
KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS
Sbjct: 1038 KGPKELDTRSLKEENFIASIGPEVIKPVFDLGETEEKKSQISADSGVSLTSSSQRTDQDS 1097
Query: 1141 VIGVSPAVMIRSSSQDSEVST-VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1199
VIGVSPAVMIRSSSQDSEVST VSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL
Sbjct: 1098 VIGVSPAVMIRSSSQDSEVSTVVSNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTL 1157
Query: 1200 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1259
SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD
Sbjct: 1158 SDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPIRTSEDVSQRVYLYEGLLGKERSTLWD 1217
Query: 1260 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1319
QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI
Sbjct: 1218 QMQFWEDAFLDAVMLEREGMGMDQGPQEMIDRYLSLGEHDRKRLEDDEDRLLATLLHNLI 1277
Query: 1320 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1379
SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK
Sbjct: 1278 SYMLLMKVNKNDIRKKVRRLMGKSHIGLVYSQQINEVLDQLANLNGRDLSIWSSGSRHMK 1337
Query: 1380 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1439
KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR
Sbjct: 1338 KQTFVVHAGTDTNGDIFFMEVCDDCVVLRSNIGTVYERWWYEKLINMTYCPKTKVLCLWR 1397
Query: 1440 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1499
RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL
Sbjct: 1398 RNGSETQLNKFYTKKCRELYYCVKDSMERAAARQQSIKPGPELGGEFPVQDLKTGEGGLL 1457
Query: 1500 QVTLEGINLKFMHNQVFIEL 1519
QVTLEGINLKFMHNQ F++L
Sbjct: 1458 QVTLEGINLKFMHNQ-FLKL 1476
>gi|239735519 SET binding factor 1 [Homo sapiens]
Length = 1893
Score = 103 bits (257), Expect = 1e-21
Identities = 133/528 (25%), Positives = 200/528 (37%), Gaps = 127/528 (24%)
Query: 10 RLLDYLVIVG-ARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRR 68
RL DY V+V HP Q ++L+R+P +D + P P + FCQP G +R
Sbjct: 3 RLADYFVLVAFGPHPRGSGEGQG-QILQRFPEKDWEDNPFPQGIELFCQPSGWQLCPER- 60
Query: 69 MSLRDDTSFVFTLTDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCAS 128
T FV LTD ++ Y C+ F+ + +E T
Sbjct: 61 ---NPPTFFVAVLTDINS-ERHYCACLTFWEPAEP--------------SQETTRV---- 98
Query: 129 EEGGTESSESGSSLQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFST 188
E TE E G D + SP A + TL + L H F
Sbjct: 99 -EDATEREEEG--------DEGGQTHLSPTAP--APSAQLFAPKTLVLVSRLDHTEVFRN 147
Query: 189 FRECLYTLK-RLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREI 247
+Y + ++ C E ++G
Sbjct: 148 SLGLIYAIHVEGLNVCLENVIG-------------------------------------- 169
Query: 248 EAWIYRLLRSPVPVSGQKRVDIEVLP---QELQPALTFALPDPSRFTLVDFPLHLPLELL 304
LL VP++G + I + Q +Q L +LP SR ++ L L
Sbjct: 170 -----NLLTCTVPLAGGSQRTISLGAGDRQVIQTPLADSLP-VSRCSVA-----LLFRQL 218
Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
G+ L + L EHKV+ SR Y L+ + +A+++PL Y F +P+LP A
Sbjct: 219 GITNVLSLFCAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILP---AQLL 275
Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLEL 424
++L PTP+IIGV A+F + + + DV + DLD V P E + I P PE L+
Sbjct: 276 EVLSTPTPFIIGVNAAF---QAETQELLDVIVADLDGGTVTIP---ECVHIPPLPEPLQS 329
Query: 425 KKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDS 484
+ H + +S+ P L L DL P P + +
Sbjct: 330 QTH-----SVLSMVLDPELELA-----------------DLAFPP-----PTTSTSSLKM 362
Query: 485 VDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPVVAFQAGSFLASR 532
D R +R F A +LQG++ +R+ P PV+ F +FL R
Sbjct: 363 QDKELRAVFLRLF--AQLLQGYRWCLHVVRIHPEPVIRFHKAAFLGQR 408
>gi|221307568 DENN/MADD domain containing 4A isoform 1 [Homo
sapiens]
Length = 1906
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
+ YG + FY + SEE TE
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
+ G + L +E+ S +H + P P
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
>gi|221307566 DENN/MADD domain containing 4A isoform 2 [Homo
sapiens]
Length = 1863
Score = 89.7 bits (221), Expect = 2e-17
Identities = 125/533 (23%), Positives = 203/533 (38%), Gaps = 123/533 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
+++V+ L+ RYP ED+ F LP V FC P G + L ++FV T
Sbjct: 203 TNTVSYKAGLICRYPQEDYESFSLPESVPLFCLPMGATIECWPSNSKYPLPVFSTFVLTG 262
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
+ YG + FY + SEE TE
Sbjct: 263 ASAEKV---YGAAIQFYEPY--------------------------SEENLTEKQRLLLG 293
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L SAD K+ S T +C+LSH+PFF FR+ L L R
Sbjct: 294 LT--SADG--------------KSDSSKTIHTNKCICLLSHWPFFDAFRKFLTFLYRY-- 335
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
+ G + L +E+ S +H + P P
Sbjct: 336 ----SISGPHV------------------LPIEKHISHFMHKV-------------PFPS 360
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L + P S L L+ LG + + +L + EHK
Sbjct: 361 PQRPRILVQLSPHD---NLILSQPVSSPLPLSGGKFSTLLQNLGPENAVTLLVFAVTEHK 417
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+P + P +PL P +A +L AP P+I+G+ + +
Sbjct: 418 ILIHSLRPSVLTSVTEALVSMIFPFHWPCPYVPLCPLALA---DVLSAPCPFIVGIDSRY 474
Query: 382 FLYKLDFKMPDDVWLVDLDSNRV--IAPTNAEVLPILPEPESLELKKHLKQALASMSLNT 439
F + P DV VD+D+N + I ILP KK K + +++
Sbjct: 475 FDL---YDPPPDVSCVDVDTNTISQIGDKKNVAWKILP-------KKPCKNLMNTLN--- 521
Query: 440 QPILNLEKFHEGQEIPLLLGRPSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNS 499
NL Q++ L RP +D + G + +D+ + A + F
Sbjct: 522 ----NLH-----QQLAKLQQRPRDDGLMDLAINDYDFNSGKRLHMIDLEIQEAFLFFM-- 570
Query: 500 ANVLQGFQMHTRTLRLFPRPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
A++L+G++ + R + P F +FL SR R F + +TQ
Sbjct: 571 ASILKGYRSYLRPITQAPSETATDAASLFALQAFLRSRDRSHQKFYNMMTKTQ 623
>gi|148922920 DENN/MADD domain containing 4B [Homo sapiens]
Length = 1496
Score = 84.0 bits (206), Expect = 1e-15
Identities = 99/392 (25%), Positives = 151/392 (38%), Gaps = 92/392 (23%)
Query: 25 SDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSV---RQRRMSLRDDTSFVFTL 81
++++ ELL RYP ED+ FPLP V FC P G Q + + ++FV T
Sbjct: 206 ANTLVYEAELLGRYPEEDNEAFPLPESVPVFCLPMGATIECWPAQTKYPVPVFSTFVLTG 265
Query: 82 TDKDTGVTRYGICVNFYRSFQKRISKEKGEGGAGSRGKEGTHATCASEEGGTESSESGSS 141
G YG + FY +F + E+ +
Sbjct: 266 A---AGDKVYGAALQFYEAFPRARLSER----------------------------QARA 294
Query: 142 LQPLSADSTPDVNQSPRGKRRAKAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVD 201
L LSA RG+ RSR + + VLS +P F FR L L R
Sbjct: 295 LGLLSAVE--------RGRALGGRAVRSRRA----IAVLSRWPAFPAFRAFLTFLYRYSV 342
Query: 202 CCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPV 261
RL +E S +H++ P P
Sbjct: 343 SGPHRLP------------------------LEAHISHFIHNV-------------PFPS 365
Query: 262 SGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHK 321
+ R+ +++ P + L P S L L+ LG + + +L +L EHK
Sbjct: 366 PQRPRILVQMSPYD---NLLLCQPVSSPLPLSGASFLQLLQSLGPELAITLLLAVLTEHK 422
Query: 322 VVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASF 381
+++ S + L+ A V+MI+PL + P IPL P +A +L AP P+I+G+ +S+
Sbjct: 423 LLVHSLRPDLLTSVCEALVSMIFPLHWQCPYIPLCPLVLA---DVLSAPVPFIVGIHSSY 479
Query: 382 FLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVL 413
F P DV VDLD+N + ++L
Sbjct: 480 FDL---HDPPADVICVDLDTNTLFQTEEKKLL 508
>gi|94818781 DENN/MADD domain containing 4C [Homo sapiens]
Length = 1673
Score = 77.4 bits (189), Expect = 1e-13
Identities = 101/395 (25%), Positives = 163/395 (41%), Gaps = 84/395 (21%)
Query: 164 KAGSRSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTM 223
K S+S N T +C+LSH+PFF FR+ L + +L + P
Sbjct: 65 KMVSKSIN-TNKCICLLSHWPFFEAFRKFLMFIYKL-----------SVSGPH------- 105
Query: 224 WRIFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFA 283
L +E+ S + ++ P P + R+ +++ + AL +
Sbjct: 106 ------PLPIEKHISHFMQNI-------------PFPSPQRPRILVQL---SVHDALILS 143
Query: 284 LPDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
P + L L LG + C +L +LLE K++L S L+ A VAMI
Sbjct: 144 QPVSTPLPLSGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMI 203
Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
+P ++ P IPL P +A+ +L AP P+I+GV + +F P DV +DLD+N
Sbjct: 204 FPFQWQCPYIPLCPLSLAA---VLSAPLPFIVGVDSRYFDL---HDPPQDVVCIDLDTNM 257
Query: 404 VIAP-----TNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLL 458
+ N + LP P L K L L+S+ TQ EG I +
Sbjct: 258 LYVSDEKKNMNWKQLPKKPCKNLLSTLKKLYPQLSSVHQKTQ---------EGSAIDM-- 306
Query: 459 GRPSNDLQSTP-STEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFP 517
TP +F+ + + +++ + A +RF A++L+G++ + R + P
Sbjct: 307 ---------TPIEADFS---WQKKMTQLEMEIQEAFLRFM--ASILKGYRTYLRPITEAP 352
Query: 518 RPVVA-----FQAGSFLASRPR-QTPFAEKLARTQ 546
F FL SR R F L++TQ
Sbjct: 353 SNKATAADSLFDRQGFLKSRDRAYAKFYTLLSKTQ 387
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 77.0 bits (188), Expect = 1e-13
Identities = 42/132 (31%), Positives = 70/132 (53%), Gaps = 5/132 (3%)
Query: 285 PDPSRFTLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIY 344
P PS L D+PL ELLG++ +QV TC+LLE +++L S+DY L +++
Sbjct: 259 PGPSELPLSDYPLREAFELLGLENLVQVFTCVLLEMQILLYSQDYQRLMTVAEGITTLLF 318
Query: 345 PLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSN 402
P ++ +P+LP AS L AP PY++G+ + + ++P + L VD+D++
Sbjct: 319 PFQWQHVYVPILP---ASLLHFLDAPVPYLMGLQSKEGTDRSKLELPQEANLCFVDIDNH 375
Query: 403 RVIAPTNAEVLP 414
+ P P
Sbjct: 376 FIELPEEFPQFP 387
>gi|29788755 SET binding factor 2 [Homo sapiens]
Length = 1849
Score = 76.6 bits (187), Expect = 2e-13
Identities = 70/252 (27%), Positives = 109/252 (43%), Gaps = 49/252 (19%)
Query: 292 LVDFPLH--LPL---------ELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFV 340
L+ PLH LP+ + LG+ L + +L E+KV+ S + LS + A
Sbjct: 183 LIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRALE 242
Query: 341 AMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLD 400
++++PL+Y +P IP+LP A ++L +PTP+IIGV + F K D DV + DLD
Sbjct: 243 SLMFPLKYSYPYIPILP---AQLLEVLSSPTPFIIGVHSVF---KTDVHELLDVIIADLD 296
Query: 401 SNRVIAPTNAEVLPILPEPESLELKKHLKQALASMSLNTQPILNLEKFHEGQEIPLLLGR 460
+ P L LPEP L Q +++SL P
Sbjct: 297 GGTIKIPECIH-LSSLPEPL-------LHQTQSALSLILHP------------------- 329
Query: 461 PSNDLQSTPSTEFNPLIYGNDVDSVDVATRVAMVRFFNSANVLQGFQMHTRTLRLFPRPV 520
DL+ P + +D R +R F A + QG++ + +R+ PV
Sbjct: 330 ---DLEVADHAFPPPRTALSHSKMLDKEVRAVFLRLF--AQLFQGYRSCLQLIRIHAEPV 384
Query: 521 VAFQAGSFLASR 532
+ F +FL R
Sbjct: 385 IHFHKTAFLGQR 396
Score = 56.2 bits (134), Expect = 2e-07
Identities = 37/111 (33%), Positives = 54/111 (48%), Gaps = 7/111 (6%)
Query: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYPLEDHTEFPLPPDVVFFCQPEGCLSVRQRRM 69
RL DY ++VG H S ++++R+P +D + P P + FCQP G R+R
Sbjct: 3 RLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER-- 60
Query: 70 SLRDDTSFVFTLTDKDTGVTRYGICVNFYRS--FQKRISKEKGEGGAGSRG 118
+ T FV LTD D+ Y C+ FY + + KE+ EG A G
Sbjct: 61 --KQPTFFVVVLTDIDSD-RHYCSCLTFYEAEINLQGTKKEEIEGEAKVSG 108
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 72.4 bits (176), Expect = 3e-12
Identities = 52/195 (26%), Positives = 96/195 (49%), Gaps = 18/195 (9%)
Query: 247 IEAWIYRLLRS-PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLG 305
+E++IY +L P+P G+ + + + P + L DFP+ ELLG
Sbjct: 240 LESYIYNVLYEVPLPPPGRS-----LKFSGVYGPIICQRPSTNELPLFDFPVKEVFELLG 294
Query: 306 VDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQ 365
V+ Q+ TC LLE +++L S+ Y L A+++P ++ +P+LP AS
Sbjct: 295 VENVFQLFTCALLEFQILLYSQHYQRLMTVAETITALMFPFQWQHVYVPILP---ASLLH 351
Query: 366 LLLAPTPYIIGVPASFFLYKLDFKMPDDVWL--VDLDSNRVIAPTNAEVLPILPE-PESL 422
L AP PY++G+ ++ + ++P + L VD+D++ + P + LP+ P L
Sbjct: 352 FLDAPVPYLMGLHSNGLDDRSKLELPQEANLCFVDIDNHFIELPED------LPQFPNKL 405
Query: 423 ELKKHLKQALASMSL 437
E + + + L + +
Sbjct: 406 EFVQEVSEILMAFGI 420
>gi|50345870 DENN/MADD domain containing 3 [Homo sapiens]
Length = 1198
Score = 72.4 bits (176), Expect = 3e-12
Identities = 59/234 (25%), Positives = 102/234 (43%), Gaps = 54/234 (23%)
Query: 176 SLCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEE 235
++CV+S +P++++ ++CL L L+ C + + D+ + F L
Sbjct: 109 AVCVVSRFPYYNSLKDCLSCLLALLKPCKD------------FEVDSHIKDFAAKL---- 152
Query: 236 KSSALLHDLREIEAWIYRLLRSPVP-----VSGQKRVDIEVLPQELQPALTFALPDPSRF 290
L+ SP P V K + I VLP P
Sbjct: 153 -----------------SLIPSPPPGPLHLVFNMKSLQI-VLPARADP----------ES 184
Query: 291 TLVDFPLHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMF 350
++D LHLPL + LQ+LTCIL E ++V S D+ L++ F+A +YPL++
Sbjct: 185 PILDLDLHLPLLCFRPEKVLQILTCILTEQRIVFFSSDWALLTLVTECFMAYLYPLQWQH 244
Query: 351 PVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRV 404
P +P+L M ++APT +++G F + K D + L+++D +
Sbjct: 245 PFVPILSDQML---DFVMAPTSFLMGCHLDHF--EEVSKEADGLVLINIDHGSI 293
>gi|47132529 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 948 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
>gi|47132532 suppression of tumorigenicity 5 isoform 1 [Homo sapiens]
Length = 1137
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 833 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 890
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 891 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 947
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 948 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 1000
>gi|21264614 suppression of tumorigenicity 5 isoform 2 [Homo
sapiens]
Length = 717
Score = 61.6 bits (148), Expect = 6e-09
Identities = 54/179 (30%), Positives = 85/179 (47%), Gaps = 11/179 (6%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L+ SP P G+ LP L P SR VDF L V +++
Sbjct: 413 LMESPFPAPGKTIKVKTFLPGAGNEVLELRRPMDSRLEHVDF--ECLFTCLSVRQLIRIF 470
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA++YP + IP+LP AS ++ PTP+
Sbjct: 471 ASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLP---ASMIDIVCCPTPF 527
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQAL 432
++G+ +S L KL ++ +V+L S+R I + E +LP +L+ L+QAL
Sbjct: 528 LVGLLSS-SLPKLKELPVEEALMVNLGSDRFIRQMDDED-TLLPR----KLQAALEQAL 580
>gi|121949817 DENN/MADD domain containing 2C [Homo sapiens]
Length = 871
Score = 58.5 bits (140), Expect = 5e-08
Identities = 50/172 (29%), Positives = 82/172 (47%), Gaps = 12/172 (6%)
Query: 249 AWIYRLLRS----PVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELL 304
A +Y +RS P P G+ LP ++ P SR VDF + L
Sbjct: 562 ALVYPFMRSVMEAPFPAPGRTITVKSYLPGAGDESIELCRPLDSRLEHVDFKCLF--KCL 619
Query: 305 GVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAE 364
V ++V +LLE +V+ + + LS A VA +YP + IP+LP AS
Sbjct: 620 SVCHLIRVCASLLLERRVIFVANSLSTLSKCGHAVVATLYPFTWQHTYIPVLP---ASMI 676
Query: 365 QLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN--AEVLP 414
++ +PTP++IG+ S L +L ++V +VDL +++ + + E+LP
Sbjct: 677 DIVCSPTPFLIGI-LSCSLPQLQDLPIEEVLIVDLCADKFLQEVSDEDEILP 727
>gi|154813195 DENN/MADD domain containing 2A [Homo sapiens]
Length = 1009
Score = 58.2 bits (139), Expect = 6e-08
Identities = 49/177 (27%), Positives = 83/177 (46%), Gaps = 7/177 (3%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
++ +P P G+ + LP + P SR VDF L V + V
Sbjct: 702 VMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDF--ESLFSSLSVRHLVCVF 759
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LLE +V+ + + LS A VA+IYP + IP+LP M ++ +PTP+
Sbjct: 760 ASLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMV---DIVCSPTPF 816
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
+IG+ +S + + ++V +VDL ++R + + E ILP + L+ L+Q
Sbjct: 817 LIGLLSSSLPLLRELPL-EEVLVVDLVNSRFLRQMDDED-SILPRKLQVALEHILEQ 871
Score = 31.2 bits (69), Expect = 8.3
Identities = 26/89 (29%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 10 RLLDYLVIVGARHPSSDSVAQTPELLRRYP--LEDHTEFPLPPDVVFFCQPEGCLSVRQR 67
+L +Y V+V H A PEL +++P LE +F + P+ C +
Sbjct: 563 QLFEYFVVVSL-HKKQAGAAYVPELTQQFPLKLERSFKFMREAEDQLKAIPQFCFPDAKD 621
Query: 68 RMSLRDDTS--FVFTLTDKDTGVTRYGIC 94
+ ++ TS F F LT +D G R+G C
Sbjct: 622 WVPVQQFTSETFSFVLTGED-GSRRFGYC 649
>gi|113205087 DENN/MADD domain containing 1C [Homo sapiens]
Length = 801
Score = 58.2 bits (139), Expect = 6e-08
Identities = 70/270 (25%), Positives = 117/270 (43%), Gaps = 36/270 (13%)
Query: 168 RSRNSTLTSLCVLSHYPFFSTFRECLYTLKRLV--DCCSERLLGKKLGIPRGVQRDTMWR 225
R R T + LC+LSH P+F F + L T+ L+ D +E + +
Sbjct: 86 RLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEA-------------EELLQN 132
Query: 226 IFTGSLLVEEKSSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALP 285
+F SL + S L L S V VS + + +P F P
Sbjct: 133 LFQQSLSGPQASVGLE-------------LGSGVTVSSGQGIPPPTRGNS-KPLSCFVAP 178
Query: 286 DPSRFTLVDFPLHLPLELLGV--DACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMI 343
D R + +L ++ V + + + +L E +V+L + + L+ V A A++
Sbjct: 179 DSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALL 238
Query: 344 YPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNR 403
YP+ + +IP LP + AP PY+IGV AS ++ K +DV ++++D+N
Sbjct: 239 YPMRWEHVLIPTLPPHLL---DYCCAPMPYLIGVHAS-LAERVREKALEDVVVLNVDAN- 293
Query: 404 VIAPTNAEVLPILPEPESLELKKHLKQALA 433
+ T +V + P+ SL + K ALA
Sbjct: 294 TLETTFNDVQALPPDVVSLLRLRLRKVALA 323
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 56.2 bits (134), Expect = 2e-07
Identities = 76/329 (23%), Positives = 124/329 (37%), Gaps = 19/329 (5%)
Query: 597 SNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPN 656
SNS + S S+ +D S SDS D DSS+S SS D + D + + +
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743
Query: 657 VDPLTHAALGDASE----VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712
D + D+S+ + + ++ + S +S N SS S+ +S+S +
Sbjct: 744 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDS 803
Query: 713 VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPY 772
+S+ +DS++ D + S S S + D + G S D+
Sbjct: 804 SNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSS- 862
Query: 773 FEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPN 832
+ D S + S N + + +SDSD+ SDS SS +
Sbjct: 863 -------NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDS-SDSSNSSDS 914
Query: 833 STVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVD 892
S SN+S S SS N S S + S+ + + + + S N D
Sbjct: 915 SDSSNSSDSS----ESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSD 970
Query: 893 QKSSVIKHSPTVKREPPSPQGRSSNSSEN 921
SS S + S SS+SS++
Sbjct: 971 SNSS--DSSDSSNSSDSSDSSDSSDSSDS 997
Score = 51.2 bits (121), Expect = 8e-06
Identities = 63/324 (19%), Positives = 123/324 (37%), Gaps = 7/324 (2%)
Query: 598 NSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNV 657
+S +++ S SDS+ +D SDS D D S SS SS S+ + D+ +
Sbjct: 563 SSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 622
Query: 658 DPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGA 717
+ + D+S+ + + + + +S++S + SS S+ +S S +
Sbjct: 623 KSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSD 682
Query: 718 NSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQY 777
+S +DS++ D + S S + D + + +
Sbjct: 683 SSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSD 742
Query: 778 GFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSN 837
+ + S + S + + + +SDS+ S+S SS +S S+
Sbjct: 743 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSD 802
Query: 838 TSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSV 897
+S S +S ++S+ S S+ + + + + + S G+ D SS
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGS-----DSDSS- 856
Query: 898 IKHSPTVKREPPSPQGRSSNSSEN 921
S + S SSNSS++
Sbjct: 857 -NRSDSSNSSDSSDSSDSSNSSDS 879
Score = 47.4 bits (111), Expect = 1e-04
Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 25/339 (7%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS-------GSDSMDYDDSSSSYSSLGDFVSEMMKC 648
DS+S + + S DSDS + DS SDS D DSS S S S+
Sbjct: 568 DSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS 627
Query: 649 DINGDTPNVDPLTHAALGDASEV----EIDELQNQKEAEEPGPDSENSQENPPLRSSSST 704
D+ + D + ++ ++S+ + + N + + S++S + SS+S+
Sbjct: 628 KSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSS 687
Query: 705 TASSSPSTVIHGANSEPADSTEMD--DKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGS 762
+S S + +S+ +DS++ D D + S S + S+ ++ + S
Sbjct: 688 DSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSS 747
Query: 763 VRRRIYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDA 822
D+ D + +S S N + NS +SDS
Sbjct: 748 DSSNSSDSSDSSDSSNSSDSSDSSDSSDSSD-------SSNSSDSNDSSNSSD-SSDSSN 799
Query: 823 ESDSRASSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPS 882
SDS SS +S S++S ++S + S++ S S+ + + + + S
Sbjct: 800 SSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRS 859
Query: 883 LKGNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 921
N D S S + S SSNSS++
Sbjct: 860 DSSNSSDSSDSSDS----SNSSDSSDSSDSNESSNSSDS 894
Score = 46.6 bits (109), Expect = 2e-04
Identities = 71/333 (21%), Positives = 119/333 (35%), Gaps = 15/333 (4%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS++ + S SDS + DS S D S SS SS S+ + D+
Sbjct: 760 DSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSD 819
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ + + D+S+ + G DS++S + SS S+ +S S ++
Sbjct: 820 SSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS 879
Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEP 775
+S+ +S+ D + S S S + D + + S DN
Sbjct: 880 SDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD--SSNSSDSSESSNSSDNSNSSD 937
Query: 776 QYGFPPEED-------EDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRA 828
D D S + S N + NS SDS SDS
Sbjct: 938 SSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNS----SDSSDSSDSSD 993
Query: 829 SSPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRR 888
SS +S SN+S S +S+ + S++ S S+ + + + + + S +
Sbjct: 994 SSDSSDSSNSSDSSDSSDSSDSSN--SSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1051
Query: 889 ALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 921
+ S S + S SS+SSE+
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084
Score = 46.2 bits (108), Expect = 3e-04
Identities = 63/272 (23%), Positives = 105/272 (38%), Gaps = 7/272 (2%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSG--SDSMDYDDSSSSYSSLGDFVSEMMKCDINGD 653
DS+ + S SDS + DS SDS D DSS S S D + D +
Sbjct: 1008 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDS-SDSSNSSDSSDSSDS 1066
Query: 654 TPNVDPLTHAALGDASEV-EIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712
+ + D + D+SE + + N ++ + S++S + SS S+ +S+S +
Sbjct: 1067 SDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1126
Query: 713 VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPY 772
+S+ +DS+ D + S S S+ ++ + S D+
Sbjct: 1127 SDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSD-SSDSSDSSDSSDSSNSSDSSD 1185
Query: 773 FEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPN 832
D + +S S S + +S +SDS+ SDS SS +
Sbjct: 1186 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSD--SSDSNESSDSSDSSDS 1243
Query: 833 STVSNTSTEGFGGIMSFASSLYRNHSTSFSLS 864
S SN+S S ++S + S S S S
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSNDESDSQSKS 1275
Score = 46.2 bits (108), Expect = 3e-04
Identities = 61/269 (22%), Positives = 103/269 (38%), Gaps = 14/269 (5%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS--GSDSMDYDDSSSSYSSLGDFVSEMMKCDINGD 653
DS+ + S SDS + DS SDS D DSS S S D D +
Sbjct: 1041 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDS-SESSDSSDSSNSSDSSDS 1099
Query: 654 TPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTV 713
+ + D + D+S + + N ++ + S++S + SS S+ +S S +
Sbjct: 1100 SDSSDSSDSSDSSDSS--DSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSS 1157
Query: 714 IHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNV--DRRQAEIGEGSVRRRIYDNP 771
+S+ +DS++ D + S S S+ ++ + S D+
Sbjct: 1158 DSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1217
Query: 772 YFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSP 831
D +E +S S S N + +S SDS+ ESDS++ S
Sbjct: 1218 DSSDSSDSSDSSDSNESSDSSDSSDSSD-SSNSSDSSDSSDSSDSTSDSNDESDSQSKSG 1276
Query: 832 NSTVSNTSTEGFGGIMSFASSLYRNHSTS 860
N + + ++ S + NHSTS
Sbjct: 1277 NGNNNGSDSD------SDSEGSDSNHSTS 1299
Score = 45.4 bits (106), Expect = 4e-04
Identities = 65/314 (20%), Positives = 119/314 (37%), Gaps = 10/314 (3%)
Query: 610 ERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDAS 669
E D++S D+ +S + D+ + S G +E D DT N D + G+
Sbjct: 480 ESDNNSSSRGDASYNSDESKDNGNGSDSKG---AEDDDSDSTSDTNNSDSNGNGNNGNDD 536
Query: 670 EVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDD 729
+ D + + ++ DS++S + SS S+ + SS S ++S +DS++ D
Sbjct: 537 NDKSDSGKGKSDSS----DSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSD 592
Query: 730 KAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEEDEDEQG 789
+ S S S + D + + + D+ + + D
Sbjct: 593 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSD 652
Query: 790 ESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRAS--SPNSTVSNTSTEGFGGIM 847
S + S + + + + +SDS SDS S S NS+ S+ S++
Sbjct: 653 NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712
Query: 848 SFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSVIKHSPTVKRE 907
S +S ++S+ SN + + + + S N D S S +
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS-SNSSDSSDSS 771
Query: 908 PPSPQGRSSNSSEN 921
S SSNSS++
Sbjct: 772 DSSDSSDSSNSSDS 785
Score = 44.7 bits (104), Expect = 7e-04
Identities = 75/337 (22%), Positives = 123/337 (36%), Gaps = 38/337 (11%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSG-----SDSMDYDDSSSSYSSLGDF----VSEMM 646
D N + DSDS + +S SDS D +SSS S D S+
Sbjct: 535 DDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSD 594
Query: 647 KCDINGDTPNVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTA 706
D + + + D + D+S+ D + ++E DS++ ++ SS S+
Sbjct: 595 SSDSSNSSDSSDSSDSSDSSDSSD-SSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN 653
Query: 707 SSSPSTVIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRR 766
S S + +S+ +DS++ D ++ S S SN ++ + S
Sbjct: 654 SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN-SSESSDSSDSS---- 708
Query: 767 IYDNPYFEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDS 826
+ D + +S S S N + NS SDS SDS
Sbjct: 709 ---------------DSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS----SDSSDSSDS 749
Query: 827 RAS--SPNSTVSNTSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLK 884
S S +S+ S+ S++ S SS N S S SN + + + + S
Sbjct: 750 SNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 885 GNRRALVDQKSSVIKHSPTVKREPPSPQGRSSNSSEN 921
+ D SS S + S SS+SS++
Sbjct: 810 SDSSDSSDSDSS--NSSDSSNSSDSSDSSNSSDSSDS 844
Score = 43.9 bits (102), Expect = 0.001
Identities = 58/261 (22%), Positives = 96/261 (36%), Gaps = 6/261 (2%)
Query: 606 SVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAAL 665
S +SDS ++G+D D DS S D S+ + D+ + +
Sbjct: 517 STSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSD--SDSSDSSNSSDSSDSSDSDSSDS 574
Query: 666 GDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADST 725
+S+ + + + ++ DS NS ++ SS ++ SS S ++ +DS+
Sbjct: 575 NSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634
Query: 726 EMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEED- 784
+ D K+ S S S S+ + + S D+ D
Sbjct: 635 DSDSKSDSSDSNSSDSSDNS--DSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDS 692
Query: 785 EDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTVSNTSTEGFG 844
D S + S + + NS SDS SDS SS NS+ S+ S++
Sbjct: 693 SDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSS-NSSDSSDSSDSSN 751
Query: 845 GIMSFASSLYRNHSTSFSLSN 865
S SS N S S S+
Sbjct: 752 SSDSSDSSDSSNSSDSSDSSD 772
Score = 41.2 bits (95), Expect = 0.008
Identities = 52/244 (21%), Positives = 93/244 (38%), Gaps = 7/244 (2%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + DS S D S+SS SS S+ + D+
Sbjct: 987 DSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSS 1046
Query: 656 NVDPLTHAALGDASEVEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIH 715
+ + ++ S D + ++ + S++S+ + SS+S+ +S S +
Sbjct: 1047 DSSDSSDSSNSSDSSDSSDS-SDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDS 1105
Query: 716 GANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPYFEP 775
+S+ +DS++ D + S S SN ++ + S D+
Sbjct: 1106 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSN----SSDSSDSSESSDSSDSSDSSD 1161
Query: 776 QYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPNSTV 835
D + +S S S + +S +SDS SDS SS +S
Sbjct: 1162 SSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSS--DSSDSSDSSDSSDSSDSSDS 1219
Query: 836 SNTS 839
S++S
Sbjct: 1220 SDSS 1223
Score = 40.8 bits (94), Expect = 0.011
Identities = 55/245 (22%), Positives = 92/245 (37%), Gaps = 27/245 (11%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTP 655
DS+ + S SDS + DS SDS D DSS S S S D + +
Sbjct: 1080 DSSESSDSSDSSNSSDSSDSSDSSDS-SDSSDSSDSSDSSDSSNSSDSS----DSSDSSD 1134
Query: 656 NVDPLTHAALGDASE-VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVI 714
+ D + D+SE + + + ++ + S++S + SS S+ +S S +
Sbjct: 1135 SSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1194
Query: 715 HGANSEPADSTEMDDKAAVGVSKPLPSVPPS--IGKSNVDRRQAEIGEGSVRRRIYDNPY 772
+S+ +DS++ D + S S SN ++ + S D+
Sbjct: 1195 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSS- 1253
Query: 773 FEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPN 832
+ D +S SQ SGN + SD++SDS S N
Sbjct: 1254 -------DSSDSSDSTSDSNDESDSQSKSGNGNN-----------NGSDSDSDSEGSDSN 1295
Query: 833 STVSN 837
+ S+
Sbjct: 1296 HSTSD 1300
Score = 39.3 bits (90), Expect = 0.031
Identities = 36/108 (33%), Positives = 46/108 (42%), Gaps = 5/108 (4%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRS----SSQDSEVSTVSNS 1165
D + S S+DS S SS DS G RS SS S+ S SNS
Sbjct: 817 DSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNS 876
Query: 1166 SGETLGADSDLSSNAGDGPGGEGSVHLASS-RGTLSDSEIETNSATST 1212
S + +DS+ SSN+ D S SS SDS +NS+ S+
Sbjct: 877 SDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSS 924
Score = 38.9 bits (89), Expect = 0.040
Identities = 29/103 (28%), Positives = 50/103 (48%), Gaps = 2/103 (1%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D +++ S S+DS S S S +D +S + S S DS+ S SNSS +
Sbjct: 548 DSSDSDSSDSSNSSDSSDS--SDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
+DS SS++ D + + S + SDS+ +++ + S+
Sbjct: 606 DSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSS 648
Score = 38.9 bits (89), Expect = 0.040
Identities = 32/131 (24%), Positives = 55/131 (41%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D +++ S S+DS S SS DS S + S S DS+ + S+ S +
Sbjct: 589 DSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSS 648
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLA 1229
+D+ SS++ + S + S + S S+ +S +S ++S + S +
Sbjct: 649 DSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSS 708
Query: 1230 GSPIRTSEDVS 1240
S S D S
Sbjct: 709 DSDSSDSSDSS 719
Score = 38.5 bits (88), Expect = 0.052
Identities = 55/247 (22%), Positives = 95/247 (38%), Gaps = 13/247 (5%)
Query: 596 DSNSQLAEALSVPPERDSDSEPTDDS--GSDSMDYDDSSSSYSSLGDFVSEMMKCDINGD 653
DS+ + S SDS + DS SDS D DSS S +S S D +
Sbjct: 975 DSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSS----DSSNS 1030
Query: 654 TPNVDPLTHAALGDASE-VEIDELQNQKEAEEPGPDSENSQENPPLRSSSSTTASSSPST 712
+ + D + D+S+ + + N ++ + S++S + SS S+ +S S +
Sbjct: 1031 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDS 1090
Query: 713 VIHGANSEPADSTEMDDKAAVGVSKPLPSVPPSIGKSNVDRRQAEIGEGSVRRRIYDNPY 772
+S+ +DS++ D + S S S+ ++ + S D+
Sbjct: 1091 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSD----SSDSSDSSDSSNSSDSSD 1146
Query: 773 FEPQYGFPPEEDEDEQGESYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRASSPN 832
D + +S S S + +S +SDS SDS SS +
Sbjct: 1147 SSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS--DSSDSSDSSDSSDSSDS 1204
Query: 833 STVSNTS 839
S S++S
Sbjct: 1205 SDSSDSS 1211
Score = 37.7 bits (86), Expect = 0.089
Identities = 71/324 (21%), Positives = 117/324 (36%), Gaps = 42/324 (12%)
Query: 618 TDDSGSDSMDYDDSSSSYSSLGDFVSEMMKCDINGDTPNVDPLTHAALGDASEVEIDELQ 677
++ G DS D+DD S GD + + + N D + ++ GDAS +
Sbjct: 445 SNSDGYDSYDFDDKSMQ----GDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKD 500
Query: 678 NQKEAEEPGPDSENSQENPPLRSSSSTTASSSPSTVIHGANSEPADSTEMDDKAAVGVSK 737
N ++ G + ++S S+S T S S N + + +DK+ G K
Sbjct: 501 NGNGSDSKGAEDDDSD------STSDTNNSDS--------NGNGNNGNDDNDKSDSGKGK 546
Query: 738 PLPSVPPSIGKSN-VDRRQAEIGEGSVRRRIYDNPYFEPQYGFPPEED------EDEQGE 790
S S SN D + + S D+ + + D + +
Sbjct: 547 SDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSD 606
Query: 791 SYTPRFSQHVSGNRAQKLLRPNSLRLASDSDAESDSRAS-------------SPNSTVSN 837
S S S + K S +SDSD++SDS S S NS+ S+
Sbjct: 607 SSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666
Query: 838 TSTEGFGGIMSFASSLYRNHSTSFSLSNLTLPTKGAREKATPFPSLKGNRRALVDQKSSV 897
S++ S +SS N S S S+ + + E + S + D +S
Sbjct: 667 DSSDSSDSSDSSSSSDSSNSSDSSDSSD----SSNSSESSDSSDSSDSDSSDSSDSSNSN 722
Query: 898 IKHSPTVKREPPSPQGRSSNSSEN 921
S + S SS+SS++
Sbjct: 723 SSDSDSSNSSDSSDSSNSSDSSDS 746
Score = 37.4 bits (85), Expect = 0.12
Identities = 32/100 (32%), Positives = 47/100 (47%), Gaps = 3/100 (3%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS + S+S DS S S+SS + +D
Sbjct: 783 SDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDS--SNSSDSSDSSNSSD 840
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGT-LSDSEIETNSATST 1212
S SS++ DG + S SS + SDS +NS+ S+
Sbjct: 841 SSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSS 880
Score = 37.0 bits (84), Expect = 0.15
Identities = 34/125 (27%), Positives = 53/125 (42%), Gaps = 4/125 (3%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S + SS S+ S S+SS +D
Sbjct: 1181 SDSSDSSDSSDSSDSSDSSDSSDSSDS----SDSSDSSDSSDSSDSSDSSDSSDSNESSD 1236
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLAGSPI 1233
S SS++ D S + S + SDS E++S + + G + + + S
Sbjct: 1237 SSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNH 1296
Query: 1234 RTSED 1238
TS+D
Sbjct: 1297 STSDD 1301
Score = 36.2 bits (82), Expect = 0.26
Identities = 32/110 (29%), Positives = 50/110 (45%), Gaps = 12/110 (10%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSS-------SQDSEVSTV 1162
D +++ S S+DS S + SS +D DS + + SS S DS S
Sbjct: 565 DSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKS 624
Query: 1163 SNSSGETLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
+S E+ +DSD S++ D + S + SS DS +NS+ S+
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSS-----DSSNSSNSSDSS 669
Score = 36.2 bits (82), Expect = 0.26
Identities = 36/131 (27%), Positives = 54/131 (41%), Gaps = 2/131 (1%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D + S S+DS S SS+ DS S S S DS S+ S+SS +
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDS--SDSNESSNSSDSSDSSNSSDSDSSDSS 909
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATSTIFGKAHSLKPSIKEKLA 1229
+DS SSN+ D S ++S + + S+ +S +S ++S S +
Sbjct: 910 NSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSS 969
Query: 1230 GSPIRTSEDVS 1240
S S D S
Sbjct: 970 DSNSSDSSDSS 980
Score = 36.2 bits (82), Expect = 0.26
Identities = 31/104 (29%), Positives = 44/104 (42%), Gaps = 11/104 (10%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D ++ S+DS S SS DS SS S+ S S+SS +
Sbjct: 893 DSSDSSNSSDSDSSDSSNSSDSSDSSNSSDS----------SESSNSSDNSNSSDSSNSS 942
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLA-SSRGTLSDSEIETNSATST 1212
+DS SSN+ D S + + SS SDS +NS+ S+
Sbjct: 943 DSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS 986
Score = 35.8 bits (81), Expect = 0.34
Identities = 28/100 (28%), Positives = 43/100 (43%), Gaps = 4/100 (4%)
Query: 1113 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGA 1172
E+ + +DS S SS+ + S + +SS S+ S SNSS + +
Sbjct: 700 ESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSS 759
Query: 1173 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
DS SS++ D S S SDS +NS+ S+
Sbjct: 760 DSSNSSDSSDSSDSSDS----SDSSNSSDSNDSSNSSDSS 795
Score = 35.8 bits (81), Expect = 0.34
Identities = 31/102 (30%), Positives = 44/102 (43%), Gaps = 9/102 (8%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D ++ + S S+DS S SS DS S DS+ S S+SS +
Sbjct: 811 DSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDS-----SDGSDSDSSNRSDSSNSS 865
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1211
+DS SSN+ D S ++S SDS +NS+ S
Sbjct: 866 DSSDSSDSSNSSDSSDSSDSNESSNS----SDSSDSSNSSDS 903
Score = 35.8 bits (81), Expect = 0.34
Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 12/99 (12%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S+S DS S S+SS + +D
Sbjct: 936 SDSSNSSDSSDSSDSSNSSDSSNSSDS-----------SNSSDSSDSNSSDSSDSSNSSD 984
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SS++ D S + + S + SDS +NS+ S+
Sbjct: 985 SSDSSDSSDSSDSSDSSNSSDSSDS-SDSSDSSNSSDSS 1022
Score = 35.4 bits (80), Expect = 0.44
Identities = 35/135 (25%), Positives = 59/135 (43%), Gaps = 6/135 (4%)
Query: 1113 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGA 1172
+++ S S+DS S + SS +D + S + +SS S+ S S+SS + +
Sbjct: 725 DSDSSNSSDSSDSSNS-SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783
Query: 1173 DSDLSSNAGDGPGGEGSVHLASSRGT-----LSDSEIETNSATSTIFGKAHSLKPSIKEK 1227
DS+ SSN+ D S ++S + SDS+ +S +S + S S
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSD 843
Query: 1228 LAGSPIRTSEDVSQR 1242
+ S + D S R
Sbjct: 844 SSDSSDGSDSDSSNR 858
Score = 35.4 bits (80), Expect = 0.44
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 5/100 (5%)
Query: 1113 ETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGA 1172
++ + S S+DS S SS DS S + SS S+ S SNSS + +
Sbjct: 967 DSSDSNSSDSSDSSNSSDSSDSSDSSDSSDS-SDSSNSSDSSDSSDSSDSSNSSDSSNSS 1025
Query: 1173 DSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
DS SS++ D S S SDS +NS+ S+
Sbjct: 1026 DSSNSSDSSDSSDSSDS----SDSSDSSDSSDSSNSSDSS 1061
Score = 35.0 bits (79), Expect = 0.58
Identities = 28/103 (27%), Positives = 44/103 (42%), Gaps = 2/103 (1%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D ++ + S+DS S SS DS S + S+S DS S+ S++S E+
Sbjct: 644 DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDS--SDSSSSSDSSNSSDSSDSSDSSNSSES 701
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
+ S++ D S S SDS +NS+ S+
Sbjct: 702 SDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744
Score = 35.0 bits (79), Expect = 0.58
Identities = 30/103 (29%), Positives = 48/103 (46%), Gaps = 6/103 (5%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D ++ S S+DS S SS D+ S + +SS S+ S SNSS +
Sbjct: 902 DSDSSDSSNSSDSSDSSNSSDSSESSNSSDN----SNSSDSSNSSDSSDSSDSSNSSDSS 957
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
+DS SS++ D + S +S+ SDS ++S+ S+
Sbjct: 958 NSSDSSNSSDSSDSNSSDSSD--SSNSSDSSDSSDSSDSSDSS 998
Score = 35.0 bits (79), Expect = 0.58
Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 1/94 (1%)
Query: 1119 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSS 1178
S S S S +S S +D S + SS S+ S SNSS + +DS SS
Sbjct: 957 SNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSS 1016
Query: 1179 NAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
N+ D S + + S + SDS ++S+ S+
Sbjct: 1017 NSSDSSNSSDSSNSSDSSDS-SDSSDSSDSSDSS 1049
Score = 34.3 bits (77), Expect = 0.98
Identities = 32/105 (30%), Positives = 46/105 (43%), Gaps = 7/105 (6%)
Query: 1114 TEEKKSQISADSGVSLTSS-----SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGE 1168
++ S S+DS S SS S +D DS + S S S S S+SS
Sbjct: 681 SDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS 740
Query: 1169 TLGADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATS 1211
+ +DS SSN+ D S + + S + SDS +NS+ S
Sbjct: 741 SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 785
Score = 33.9 bits (76), Expect = 1.3
Identities = 31/103 (30%), Positives = 45/103 (43%), Gaps = 2/103 (1%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D ++ S S+DS S SS DS S + SS S S SNSS +
Sbjct: 970 DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSS-NSSDSSDSSDSSDSSNSSDSSNSSDSS 1028
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
+DS SS++ D S + S + SDS ++S+ S+
Sbjct: 1029 NSSDSSDSSDSSDSSDSSDSSDSSDSSNS-SDSSDSSDSSDSS 1070
Score = 33.9 bits (76), Expect = 1.3
Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 5/99 (5%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S + SS S+ S S+SS + +D
Sbjct: 1118 SDSSNSSDSSDSSDSSDSSDSSNSSDS----SDSSESSDSSDSSDSSDSSDSSDSSDSSD 1173
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SSN+ D S + S + SDS ++S+ S+
Sbjct: 1174 SSDSSNSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1211
Score = 33.5 bits (75), Expect = 1.7
Identities = 30/102 (29%), Positives = 46/102 (45%), Gaps = 2/102 (1%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D ++E S + S S ++SS +D S + SS S+ S S+SS +
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSS 684
Query: 1170 LGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1211
+DS SS++ + E S SS SDS +NS +S
Sbjct: 685 NSSDSSDSSDSSN--SSESSDSSDSSDSDSSDSSDSSNSNSS 724
Score = 33.5 bits (75), Expect = 1.7
Identities = 31/101 (30%), Positives = 45/101 (44%), Gaps = 6/101 (5%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGE--TLG 1171
++ S S+DS S SS +S + S S DS S+ SNSS +
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNS 731
Query: 1172 ADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
+DS SSN+ D S + + S SDS +NS+ S+
Sbjct: 732 SDSSDSSNSSDSSDSSDSSNSSDS----SDSSDSSNSSDSS 768
Score = 33.5 bits (75), Expect = 1.7
Identities = 30/99 (30%), Positives = 47/99 (47%), Gaps = 5/99 (5%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS+ DS S + +SS S S SNSS + +D
Sbjct: 983 SDSSDSSDSSDSSDSSDSSNSSDSSDS----SDSSDSSNSSDSSNSSDSSNSSDSSDSSD 1038
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SS++ D S + + S + SDS ++S+ S+
Sbjct: 1039 SSDSSDSSDSSDSSDSSNSSDSSDS-SDSSDSSDSSDSS 1076
Score = 33.5 bits (75), Expect = 1.7
Identities = 28/98 (28%), Positives = 44/98 (44%), Gaps = 4/98 (4%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS+ DS S + SS S+ S SNSS + +D
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDS----SDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1065
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1211
S SS++ D S + S + + S+ +S +S
Sbjct: 1066 SSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSS 1103
Score = 33.5 bits (75), Expect = 1.7
Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 4/103 (3%)
Query: 1114 TEEKKSQISADSGVSLTSS--SQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLG 1171
++ S S+DS S SS S +D S + SS S+ S S+SS +
Sbjct: 1025 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084
Query: 1172 ADSDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1212
+DS SSN+ D S + S + SDS +NS+ S+
Sbjct: 1085 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1127
Score = 33.5 bits (75), Expect = 1.7
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 5/99 (5%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ +S S+DS S SS DS S + SS S+ S S+SS + +D
Sbjct: 1079 SDSSESSDSSDSSNSSDSSDSSDSSDS----SDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1134
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SSN+ D S + S + SDS ++S+ S+
Sbjct: 1135 SSDSSNSSDSSDSSESSDSSDSSDS-SDSSDSSDSSDSS 1172
Score = 33.5 bits (75), Expect = 1.7
Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 2/99 (2%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S + SS S+ S S+SS + +D
Sbjct: 1088 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDS-SDSSNSSDSSDSSDSSDSSDSSNSSDSSD 1146
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SS++ D S + S + SDS +NS+ S+
Sbjct: 1147 SSESSDSSDSSDSSDSSDSSDSSDS-SDSSDSSNSSDSS 1184
Score = 33.1 bits (74), Expect = 2.2
Identities = 30/104 (28%), Positives = 48/104 (46%), Gaps = 2/104 (1%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDS-EVSTVSNSSGE 1168
D ++ + + S+DS S +S S + S S S S DS + S S+SS
Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS 770
Query: 1169 TLGADSDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
+ +DS SSN+ D S + S + SDS ++S+ S+
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNS-SDSSNSSDSSDSS 813
Score = 33.1 bits (74), Expect = 2.2
Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 11/99 (11%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS SS+ S+ S SNSS + +D
Sbjct: 1052 SDSSNSSDSSDSSDSSDSSDSSDSSDS----------SDSSESSDSSDSSNSSDSSDSSD 1101
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SS++ D S ++S + SDS ++S+ S+
Sbjct: 1102 SSDSSDSSDSSDSSDSSDSSNSSDS-SDSSDSSDSSDSS 1139
Score = 33.1 bits (74), Expect = 2.2
Identities = 28/98 (28%), Positives = 42/98 (42%), Gaps = 4/98 (4%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S + SS S+ S S+SS + +D
Sbjct: 1061 SDSSDSSDSSDSSDSSDSSDSSESSDS----SDSSNSSDSSDSSDSSDSSDSSDSSDSSD 1116
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1211
S SSN+ D S + S + S+ +S +S
Sbjct: 1117 SSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSS 1154
Score = 33.1 bits (74), Expect = 2.2
Identities = 30/99 (30%), Positives = 46/99 (46%), Gaps = 5/99 (5%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS+ DS S + SS S+ S S+SS + +D
Sbjct: 1160 SDSSDSSDSSDSSDSSDSSNSSDSSDS----SDSSDSSDSSDSSDSSDSSDSSDSSDSSD 1215
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SS++ D S + S + SDS +NS+ S+
Sbjct: 1216 SSDSSDSSDSSDSSDSNESSDSSDS-SDSSDSSNSSDSS 1253
Score = 32.7 bits (73), Expect = 2.9
Identities = 27/99 (27%), Positives = 44/99 (44%), Gaps = 2/99 (2%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS + DS S S S +S S+ S+ S ++ +D
Sbjct: 657 SDSSNSSNSSDSSDSSDSSDSSSSSDS--SNSSDSSDSSDSSNSSESSDSSDSSDSDSSD 714
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SSN+ + +S SDS ++S+ S+
Sbjct: 715 SSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS 753
Score = 32.7 bits (73), Expect = 2.9
Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 4/98 (4%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S + +SS S+ S S+SS + +D
Sbjct: 995 SDSSDSSNSSDSSDSSDSSDSSNSSDS----SNSSDSSNSSDSSDSSDSSDSSDSSDSSD 1050
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1211
S SSN+ D S + S + S+ +S +S
Sbjct: 1051 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSS 1088
Score = 32.7 bits (73), Expect = 2.9
Identities = 30/99 (30%), Positives = 45/99 (45%), Gaps = 5/99 (5%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S + SS S+ S SNSS + +D
Sbjct: 1133 SDSSDSSNSSDSSDSSESSDSSDSSDS----SDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SS++ D S + S + SDS ++S+ S+
Sbjct: 1189 SSDSSDSSDSSDSSDSSDSSDSSDS-SDSSDSSDSSDSS 1226
Score = 32.3 bits (72), Expect = 3.7
Identities = 30/105 (28%), Positives = 43/105 (40%), Gaps = 13/105 (12%)
Query: 1110 DLGETEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGET 1169
D ++ S ++DS S SS+ DS SS S S SNSS +
Sbjct: 641 DSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS----------SDSSDSSSSSDSSNSSDSS 690
Query: 1170 LGADSDLS---SNAGDGPGGEGSVHLASSRGTLSDSEIETNSATS 1211
+DS S S++ D + S SS SDS+ +S +S
Sbjct: 691 DSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735
Score = 32.3 bits (72), Expect = 3.7
Identities = 30/94 (31%), Positives = 43/94 (45%), Gaps = 2/94 (2%)
Query: 1119 SQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGADSDLSS 1178
S S+DS S SS DS S + SS S+ S S+SS + +DS SS
Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDSS-NSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSS 1064
Query: 1179 NAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
++ D S + S + SDS +NS+ S+
Sbjct: 1065 DSSDSSDSSDSSDSSDSSES-SDSSDSSNSSDSS 1097
Score = 31.6 bits (70), Expect = 6.4
Identities = 23/63 (36%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query: 1151 RSSSQDSEVSTVSNSSGETLGADSDLS-SNAGDGPGGEGSVHLASSRGTLSDSEIETNSA 1209
+S S DS+ S SNSS + +DSD S SN+ S SS SDS ++S+
Sbjct: 546 KSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSS 605
Query: 1210 TST 1212
S+
Sbjct: 606 DSS 608
Score = 31.6 bits (70), Expect = 6.4
Identities = 31/101 (30%), Positives = 43/101 (42%), Gaps = 7/101 (6%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S + SS S S SNSS + +D
Sbjct: 912 SDSSDSSNSSDSSESSNSSDNSNSSDS----SNSSDSSDSSDSSNSSDSSNSSDSSNSSD 967
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGT--LSDSEIETNSATST 1212
S SN+ D S + S + SDS +NS+ S+
Sbjct: 968 SS-DSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSS 1007
Score = 31.6 bits (70), Expect = 6.4
Identities = 29/99 (29%), Positives = 45/99 (45%), Gaps = 5/99 (5%)
Query: 1114 TEEKKSQISADSGVSLTSSSQRTDQDSVIGVSPAVMIRSSSQDSEVSTVSNSSGETLGAD 1173
++ S S+DS S SS DS S + SS S+ S SNSS + +D
Sbjct: 1076 SDSSDSSESSDSSDSSNSSDSSDSSDS----SDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1131
Query: 1174 SDLSSNAGDGPGGEGSVHLASSRGTLSDSEIETNSATST 1212
S SS++ + S + S + SDS ++S+ S+
Sbjct: 1132 SSDSSDSSNSSDSSDSSESSDSSDS-SDSSDSSDSSDSS 1169
>gi|188219541 DENN/MADD domain containing 1B isoform 2 [Homo
sapiens]
Length = 426
Score = 55.8 bits (133), Expect = 3e-07
Identities = 62/261 (23%), Positives = 110/261 (42%), Gaps = 45/261 (17%)
Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
LC+LS+ P+F + + L TL L +E
Sbjct: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDI---EVLPQE--LQPALTFALPDPSRFT 291
+ L LR + +PV +S + + I +VL + L P F PD +
Sbjct: 123 ENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKDQPALVPHSYFIAPDVTGLP 182
Query: 292 LVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYM 349
+ +L + VD LQ+ +L E ++V+ S + L+ + A++YP+ +
Sbjct: 183 TIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQ 242
Query: 350 FPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTN 409
IP+LP + AP PY+IG+ +S + ++ K +DV ++++D+N + +P +
Sbjct: 243 HIYIPVLPPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFS 298
Query: 410 AEVLPILPEPESLELKKHLKQ 430
L LP LK LK+
Sbjct: 299 D--LNNLPSDVVSALKNKLKK 317
>gi|218563726 DENN/MADD domain containing 1B isoform 1 [Homo
sapiens]
Length = 755
Score = 52.4 bits (124), Expect = 3e-06
Identities = 59/254 (23%), Positives = 105/254 (41%), Gaps = 51/254 (20%)
Query: 177 LCVLSHYPFFSTFRECLYTLKRLVDCCSERLLGKKLGIPRGVQRDTMWRIFTGSLLVEEK 236
LC+LS+ P+F + + L TL L +E
Sbjct: 95 LCILSYLPWFEVYYKLLNTL--------------------------------ADYLAKEL 122
Query: 237 SSALLHDLREIEAWIYRLLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFP 296
+ L LR L PVP + V++ V + P +T P L ++
Sbjct: 123 ENDLNETLRS-------LYNHPVPKANTP-VNLSVHSYFIAPDVTGLPTIPESRNLTEY- 173
Query: 297 LHLPLELLGVDACLQVLTCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLL 356
+ V+ LQ+ +L E ++V+ S + L+ + A++YP+ + IP+L
Sbjct: 174 ----FVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYPMYWQHIYIPVL 229
Query: 357 PTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDLDSNRVIAPTNAEVLPIL 416
P + AP PY+IG+ +S + ++ K +DV ++++D+N + +P + L L
Sbjct: 230 PPHLL---DYCCAPMPYLIGIHSS-LIERVKNKSLEDVVMLNVDTNTLESPFSD--LNNL 283
Query: 417 PEPESLELKKHLKQ 430
P LK LK+
Sbjct: 284 PSDVVSALKNKLKK 297
>gi|21361991 DENN/MADD domain containing 2D [Homo sapiens]
Length = 471
Score = 51.2 bits (121), Expect = 8e-06
Identities = 37/146 (25%), Positives = 65/146 (44%), Gaps = 6/146 (4%)
Query: 254 LLRSPVPVSGQKRVDIEVLPQELQPALTFALPDPSRFTLVDFPLHLPLELLGVDACLQVL 313
L + P G+ +P ++ P S VDF L L + LQ+
Sbjct: 191 LREAAFPAPGKTVTLKSFIPDSGTEFISLTRPLDSHLEHVDFSSLL--HCLSFEQILQIF 248
Query: 314 TCILLEHKVVLQSRDYNALSMSVMAFVAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPY 373
+LE K++ + + LS + A A++YP + IP++P + + + PTP+
Sbjct: 249 ASAVLERKIIFLAEGLSTLSQCIHAAAALLYPFSWAHTYIPVVPESLLAT---VCCPTPF 305
Query: 374 IIGVPASFFLYKLDFKMPDDVWLVDL 399
++GV F +D M ++V LV+L
Sbjct: 306 MVGVQMRFQQEVMDSPM-EEVLLVNL 330
>gi|55749789 DENN/MADD domain containing 1A isoform 2 [Homo sapiens]
Length = 559
Score = 48.9 bits (115), Expect = 4e-05
Identities = 39/151 (25%), Positives = 69/151 (45%), Gaps = 8/151 (5%)
Query: 282 FALPDPSRFTLVDFPLHLPLELLGVDA--CLQVLTCILLEHKVVLQSRDYNALSMSVMAF 339
F +PD + +L + VD L + +L E ++++ + L+ +
Sbjct: 155 FTVPDTRELPSIPENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGS 214
Query: 340 VAMIYPLEYMFPVIPLLPTCMASAEQLLLAPTPYIIGVPASFFLYKLDFKMPDDVWLVDL 399
AM+YP+ + IP+LP + AP PY+IG+ S + K+ DDV ++++
Sbjct: 215 AAMLYPMYWQHVYIPVLPPHLL---DYCCAPMPYLIGIHLS-LMEKVRNMALDDVVILNV 270
Query: 400 DSNRVIAPTNAEVLPILPEPESLELKKHLKQ 430
D+N + P + L LP LK LK+
Sbjct: 271 DTNTLETP--FDDLQSLPNDVISSLKNRLKK 299
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.132 0.383
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,813,430
Number of Sequences: 37866
Number of extensions: 3146621
Number of successful extensions: 14816
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 194
Number of HSP's that attempted gapping in prelim test: 13138
Number of HSP's gapped (non-prelim): 1255
length of query: 1587
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1471
effective length of database: 13,855,062
effective search space: 20380796202
effective search space used: 20380796202
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.