Search of human proteins with 206725456

Search of human proteins with 206725456

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|206725456 zinc activated ligand-gated ion channel [Homo
sapiens]
         (412 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]   830   0.0  
gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform...   110   3e-24
gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]   105   7e-23
gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform...   105   1e-22
gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]   104   1e-22
gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor...    97   3e-20
gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform...    94   3e-19
gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [H...    78   2e-14
gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]    78   2e-14
gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3 [...    74   3e-13
gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]     71   2e-12
gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo sapi...    70   3e-12
gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor [...    67   2e-11
gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit prec...    64   2e-10
gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]    64   2e-10
gi|41327726 nicotinic acetylcholine receptor beta 1 subunit prec...    64   3e-10
gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b prec...    61   2e-09
gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide ...    59   6e-09
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...    59   8e-09
gi|4502833 neuronal nicotinic acetylcholine receptor beta 2 prec...    54   3e-07
gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a pre...    54   3e-07
gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]               53   4e-07
gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]      53   6e-07
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre...    52   8e-07
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]        51   2e-06
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]          51   2e-06
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso...    50   3e-06
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]        50   4e-06
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec...    50   4e-06
gi|4557461 nicotinic acetylcholine receptor delta polypeptide pr...    50   5e-06

>gi|206725456 zinc activated ligand-gated ion channel [Homo sapiens]
          Length = 412

 Score =  830 bits (2143), Expect = 0.0
 Identities = 412/412 (100%), Positives = 412/412 (100%)

Query: 1   MMALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPL 60
           MMALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPL
Sbjct: 1   MMALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPL 60

Query: 61  LVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPWESLWTPRL 120
           LVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPWESLWTPRL
Sbjct: 61  LVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPWESLWTPRL 120

Query: 121 TILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALSN 180
           TILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALSN
Sbjct: 121 TILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALSN 180

Query: 181 TAMELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVP 240
           TAMELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVP
Sbjct: 181 TAMELEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVP 240

Query: 241 AEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTIL 300
           AEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTIL
Sbjct: 241 AEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTIL 300

Query: 301 LLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPRGEQREHGNPGPHPAEEPSRGVKGSQR 360
           LLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPRGEQREHGNPGPHPAEEPSRGVKGSQR
Sbjct: 301 LLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPRGEQREHGNPGPHPAEEPSRGVKGSQR 360

Query: 361 SWPETADRIFFLVYVVGVLCTQFVFAGIWMWAACKSDAAPGEAAPHGRRPRL 412
           SWPETADRIFFLVYVVGVLCTQFVFAGIWMWAACKSDAAPGEAAPHGRRPRL
Sbjct: 361 SWPETADRIFFLVYVVGVLCTQFVFAGIWMWAACKSDAAPGEAAPHGRRPRL 412


>gi|253735700 5-hydroxytryptamine (serotonin) receptor 3A isoform b
           precursor [Homo sapiens]
          Length = 484

 Score =  110 bits (274), Expect = 3e-24
 Identities = 80/337 (23%), Positives = 149/337 (44%), Gaps = 17/337 (5%)

Query: 2   MALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVN--LSKKVQESIQIPNNGSAP 59
           M LW  +    L   +  LL  G+  +      P+L  ++  L    ++ ++   +   P
Sbjct: 7   MLLW--VQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKP 64

Query: 60  LLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHA-ITLPWESLWTP 118
             V + V V  + NVD     +++ +  R  W D  L WN         +++P +S+W P
Sbjct: 65  TTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVP 124

Query: 119 RLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYAL 178
            + I E + V      P   +   G V+    L   T C+ ++ +FP D  NCSL+F + 
Sbjct: 125 DILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSW 184

Query: 179 SNTAMELEFQAHVVNEIVSVKREYVV------------YDLKTQVPPQQLVPCFQVTLRL 226
            +T  ++      + E V   R   +            Y  +  +         +  + +
Sbjct: 185 LHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVI 244

Query: 227 KNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSS 286
           +   L  +++LL+P+  L++ D+ G  LP  + ER+ +K+TLLL Y V    +   LP++
Sbjct: 245 RRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPAT 304

Query: 287 SSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNL 323
           +   PL+  YF + + LL +S  ET+ +  L+ + +L
Sbjct: 305 AIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDL 341


>gi|47519913 5-hydroxytryptamine receptor 3 subunit E [Homo sapiens]
          Length = 471

 Score =  105 bits (262), Expect = 7e-23
 Identities = 100/390 (25%), Positives = 176/390 (45%), Gaps = 56/390 (14%)

Query: 6   SLLHLTF----LGFSITLLLVHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPLL 61
           +LLHLT      G  +T   ++  GF G     P+  N   ++K    +    N S P  
Sbjct: 26  ALLHLTHSMSTTGRGVTFT-INCSGF-GQHGADPTALNSVFNRKPFRPV---TNISVPTQ 80

Query: 62  VDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTS-AHPRHAITLPWESLWTPRL 120
           V++   +S + +V+   + +SS L L + W +  ++WN         +++  ++LW P +
Sbjct: 81  VNISFAMSAILDVNEQLHLLSSFLWLEMVWDNPFISWNPEECEGITKMSMAAKNLWLPDI 140

Query: 121 TILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSF----Y 176
            I+E + VD   +   A V  +G ++    +  ++ CN ++ +FP D  NC+L+F    Y
Sbjct: 141 FIIELMDVDKTPKGLTAYVSNEGRIRYKKPMKVDSICNLDIFYFPFDQQNCTLTFSSFLY 200

Query: 177 ALSNTAMELEFQAHVVNE----IVSVKREYVVYDLKTQVPP--------QQLVPCFQVTL 224
            + +  +++E +   + +    I+    E+ +  L               Q+V  F V +
Sbjct: 201 TVDSMLLDMEKEVWEITDASRNILQTHGEWELLGLSKATAKLSRGGNLYDQIV--FYVAI 258

Query: 225 RLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALP 284
           R + +    +I LLVP+  L+  D     LP+++  R+ +K+TLLL Y V    +   LP
Sbjct: 259 RRRPSLY--VINLLVPSGFLVAIDALSFYLPVKSGNRVPFKITLLLGYNVFLLMMSDLLP 316

Query: 285 SSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPR---------- 334
           +S +  PL+  YF + L L+  S +ET+ +  LL      A + P P PR          
Sbjct: 317 TSGT--PLIGVYFALCLSLMVGSLLETIFITHLLH----VATTQPPPLPRWLHSLLLHCN 370

Query: 335 --------GEQREHGNPGPHPAEEPSRGVK 356
                     Q+E+  PG  P   P  GVK
Sbjct: 371 SPGRCCPTAPQKENKGPGLTPTHLP--GVK 398


>gi|253735691 5-hydroxytryptamine (serotonin) receptor 3A isoform c
           [Homo sapiens]
          Length = 463

 Score =  105 bits (261), Expect = 1e-22
 Identities = 70/278 (25%), Positives = 127/278 (45%), Gaps = 13/278 (4%)

Query: 59  PLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHA-ITLPWESLWT 117
           P  V + V V  + NVD     +++ +  R  W D  L WN         +++P +S+W 
Sbjct: 43  PTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWV 102

Query: 118 PRLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYA 177
           P + I E + V      P   +   G V+    L   T C+ ++ +FP D  NCSL+F +
Sbjct: 103 PDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTS 162

Query: 178 LSNTAMELEFQAHVVNEIVSVKREYVV------------YDLKTQVPPQQLVPCFQVTLR 225
             +T  ++      + E V   R   +            Y  +  +         +  + 
Sbjct: 163 WLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVV 222

Query: 226 LKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPS 285
           ++   L  +++LL+P+  L++ D+ G  LP  + ER+ +K+TLLL Y V    +   LP+
Sbjct: 223 IRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPA 282

Query: 286 SSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNL 323
           ++   PL+  YF + + LL +S  ET+ +  L+ + +L
Sbjct: 283 TAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDL 320


>gi|47519867 5-hydroxytryptamine receptor 3 subunit C [Homo sapiens]
          Length = 447

 Score =  104 bits (260), Expect = 1e-22
 Identities = 94/379 (24%), Positives = 165/379 (43%), Gaps = 38/379 (10%)

Query: 5   WSLLHLTFLGFSITLLLVHGQGFQGTA--------AIWPSLFNVNLSKKVQESIQIPNNG 56
           W       L  +++LLL  G+G   T          + P++F     +K         N 
Sbjct: 5   WPARQSALLCLTVSLLL-QGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPF---TNY 60

Query: 57  SAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESL 115
           S P  V++   +S +  VD     ++S L + L W +  + WN       + +T+  E+L
Sbjct: 61  SIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENL 120

Query: 116 WTPRLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSF 175
           W P + I+E++ VD       A +  +G +K +  +   + CN ++ +FP D  NC+ +F
Sbjct: 121 WLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTF 180

Query: 176 ----YALSNTAMELEFQAHVVNE----IVSVKREYVVYDLKTQVPPQQL------VPCFQ 221
               Y + +  + ++ +   + +    ++  + E+ +  +    P   +         F 
Sbjct: 181 SSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFY 240

Query: 222 VTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQ 281
           V +R + +    II LLVP+  L+  D     LP  +  R  +K+TLLL Y V    +  
Sbjct: 241 VAIRRRPSLY--IINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMND 298

Query: 282 ALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGAKSGPSPAPRGEQR--- 338
            LP+S +  PL+  YF + L L+ +S +ETV +  LL      A + P P PR       
Sbjct: 299 LLPASGT--PLISVYFALCLSLMVVSLLETVFITYLLH----VATTQPPPMPRWLHSLLL 352

Query: 339 EHGNPGPHPAEEPSRGVKG 357
              +PG      P +G KG
Sbjct: 353 HCTSPGRCCPTAPQKGNKG 371


>gi|5174469 5-hydroxytryptamine (serotonin) receptor 3B precursor
           [Homo sapiens]
          Length = 441

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 79/349 (22%), Positives = 150/349 (42%), Gaps = 25/349 (7%)

Query: 42  LSKKVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTS 101
           L +K  + ++   N +    V + +FV  + +VD     + + +  +  W D  L+WN+S
Sbjct: 39  LLQKYHKEVRPVYNWTKATTVYLDLFVHAILDVDAENQILKTSVWYQEVWNDEFLSWNSS 98

Query: 102 AHPR-HAITLPWESLWTPRLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFE 160
                  I+LP  ++W P + I E + ++     P   V+  G ++    +   + C+ E
Sbjct: 99  MFDEIREISLPLSAIWAPDIIINEFVDIERYPDLPYVYVNSSGTIENYKPIQVVSACSLE 158

Query: 161 LLHFPRDHSNCSLSFYALSNTAMELEF------------QAHVVN----EIVSVKREYVV 204
              FP D  NCSL+F ++ +T  +++             +   +N    E++SV   Y +
Sbjct: 159 TYAFPFDVQNCSLTFKSILHTVEDVDLAFLRSPEDIQHDKKAFLNDSEWELLSVSSTYSI 218

Query: 205 YDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGY 264
                    Q      Q  + ++   L  +++LL+P+  L+L D+    LP     RI +
Sbjct: 219 LQSSAGGFAQ-----IQFNVVMRRHPLVYVVSLLIPSIFLMLVDLGSFYLPPNCRARIVF 273

Query: 265 KVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLG 324
           K ++L+ Y V   ++   +P S    PL+ ++FTI +  L LS  ++++L   L     G
Sbjct: 274 KTSVLVGYTVFRVNMSNQVPRSVGSTPLIGHFFTICMAFLVLSLAKSIVLVKFLHDEQRG 333

Query: 325 AKSGPSPAPRGE---QREHGNPGPHPAEEPSRGVKGSQRSWPETADRIF 370
            +  P    RG+    R    P    A      + G   + P T   ++
Sbjct: 334 GQEQPFLCLRGDTDADRPRVEPRAQRAVVTESSLYGEHLAQPGTLKEVW 382


>gi|253735697 5-hydroxytryptamine (serotonin) receptor 3A isoform a
           precursor [Homo sapiens]
          Length = 516

 Score = 93.6 bits (231), Expect = 3e-19
 Identities = 71/307 (23%), Positives = 132/307 (42%), Gaps = 17/307 (5%)

Query: 2   MALWSLLHLTFLGFSITLLLVHGQGFQGTAAIWPSLFNVN--LSKKVQESIQIPNNGSAP 59
           M LW  +    L   +  LL  G+  +      P+L  ++  L    ++ ++   +   P
Sbjct: 7   MLLW--VQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKP 64

Query: 60  LLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHA-ITLPWESLWTP 118
             V + V V  + NVD     +++ +  R  W D  L WN         +++P +S+W P
Sbjct: 65  TTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVP 124

Query: 119 RLTILEALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYAL 178
            + I E + V      P   +   G V+    L   T C+ ++ +FP D  NCSL+F + 
Sbjct: 125 DILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSW 184

Query: 179 SNTAMELEFQAHVVNEIVSVKREYVV------------YDLKTQVPPQQLVPCFQVTLRL 226
            +T  ++      + E V   R   +            Y  +  +         +  + +
Sbjct: 185 LHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVI 244

Query: 227 KNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSS 286
           +   L  +++LL+P+  L++ D+ G  LP  + ER+ +K+TLLL Y V    +   LP++
Sbjct: 245 RRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPAT 304

Query: 287 SSCNPLL 293
           +   PL+
Sbjct: 305 AIGTPLI 311


>gi|4502831 cholinergic receptor, nicotinic, alpha 7 precursor [Homo
           sapiens]
          Length = 502

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 67/276 (24%), Positives = 125/276 (45%), Gaps = 23/276 (8%)

Query: 55  NGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWE 113
           N S PL V   + +  + +VD     +++ + L++SW D  L WN S +P    +  P  
Sbjct: 46  NDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDG 105

Query: 114 SLWTPRLTILEALWVDWRDQSP---QARVDQDGHVKLNLALATETNCNFELLHFPRDHSN 170
            +W P + +  +   D R  +       V+  GH +       +++C  ++  FP D  +
Sbjct: 106 QIWKPDILLYNS--ADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQH 163

Query: 171 CSLSF-------YALSNTAMELEFQAHVVN---EIVSV--KREYVVYDLKTQVPPQQLVP 218
           C L F       ++L     E +   ++ N   ++V +  KR    Y+   +  P     
Sbjct: 164 CKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVT-- 221

Query: 219 CFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSS 278
            F VT+R +   L   + LL+P   +    +   LLP  + E+I   +T+LLS  V    
Sbjct: 222 -FTVTMRRRT--LYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLL 278

Query: 279 LVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLL 314
           + + +P++S   PL+  YF   ++++ LS + TV++
Sbjct: 279 VAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIV 314


>gi|19923122 cholinergic receptor, nicotinic, alpha 3 [Homo sapiens]
          Length = 505

 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 64/285 (22%), Positives = 127/285 (44%), Gaps = 13/285 (4%)

Query: 42  LSKKVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTS 101
           L +   E I+   N S P+++   V +S +  VD +   M + L L+  W D +L WN S
Sbjct: 42  LFEDYNEIIRPVANVSDPVIIHFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWNPS 101

Query: 102 AHP-RHAITLPWESLWTPRLTILEALWVDWR-DQSPQARVDQDGHVKLNLALATETNCNF 159
            +     + +P + +W P + +      D++ D   +A +   G V        +++C  
Sbjct: 102 DYGGAEFMRVPAQKIWKPDIVLYNNAVGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKI 161

Query: 160 ELLHFPRDHSNCSLSF--YALSNTAMELEFQAHVVN--------EIVSVKREYVVYDLKT 209
           ++ +FP D+ NC++ F  ++     ++L      +N        E   +K     +D+K 
Sbjct: 162 DVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHDIKY 221

Query: 210 QVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLL 269
               +++ P    +L ++   L   I L++P   +    V    LP    E++   +++L
Sbjct: 222 NCC-EEIYPDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVL 280

Query: 270 LSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLL 314
           LS  V    + + +PS+S   PL+  Y    ++ + LS + TV +
Sbjct: 281 LSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFV 325


>gi|4502835 cholinergic receptor, nicotinic, beta polypeptide 3
           [Homo sapiens]
          Length = 458

 Score = 73.6 bits (179), Expect = 3e-13
 Identities = 66/270 (24%), Positives = 120/270 (44%), Gaps = 21/270 (7%)

Query: 68  VSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTILEAL 126
           +S + +VD     M++ + L+  W D +L WN   +   H+I +P ESLW P + + E  
Sbjct: 62  ISQLVDVDEKNQLMTTNVWLKQEWTDHKLRWNPDDYGGIHSIKVPSESLWLPDIVLFEN- 120

Query: 127 WVDWRDQSP---QARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSF--YALSNT 181
             D R +     +  V  +G V      + +++C  ++  FP D  NCS+ F  +    T
Sbjct: 121 -ADGRFEGSLMTKVIVKSNGTVVWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGT 179

Query: 182 AMELEFQAHVVNEIVSVKR-----EYVVYDLKTQVPPQQ----LVPCFQVTLRLKNTALK 232
            ++L     ++NE V  K      E+ + + K     ++      P    +  L+   L 
Sbjct: 180 MVDLI----LINENVDRKDFFDNGEWEILNAKGMKGNRRDGVYSYPFITYSFVLRRLPLF 235

Query: 233 SIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPL 292
             + L++P   L    V    LP    E++    ++L+S  V    + + +PSSS   PL
Sbjct: 236 YTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPL 295

Query: 293 LIYYFTILLLLLFLSTIETVLLAGLLARGN 322
           +  Y   +++ + LS I TV +  +  R +
Sbjct: 296 IGEYLLFIMIFVTLSIIVTVFVINVHHRSS 325


>gi|4757982 cholinergic receptor, nicotinic, alpha 6 [Homo sapiens]
          Length = 494

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 68/329 (20%), Positives = 135/329 (41%), Gaps = 32/329 (9%)

Query: 19  LLLVHGQGF-QGTAAIWPSLFNV----------------NLSKKVQESIQIPNNGSAPLL 61
           +L   GQGF  G   +W  +F                   L     + I+   N S P+ 
Sbjct: 1   MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVT 60

Query: 62  VDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRL 120
           V   V ++ + NVD +   M + L LR  W D +L W+   +     + +P + +W P +
Sbjct: 61  VHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDI 120

Query: 121 TILEALWVDWR-DQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALS 179
            +      D++ +   +A +  +G +        +++C  ++  FP DH NCSL F + +
Sbjct: 121 VLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWT 180

Query: 180 NTAMELEFQAHVVNEIVSVK-----REYVVYDLKTQVPPQQLVPCFQV------TLRLKN 228
               E++    ++   V +       E+ + D        +   C ++      +  ++ 
Sbjct: 181 YDKAEIDLL--IIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRR 238

Query: 229 TALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSS 288
             +   I L++P   +    V    LP    E++   +++LLS  V    + + +PS+S 
Sbjct: 239 LPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSL 298

Query: 289 CNPLLIYYFTILLLLLFLSTIETVLLAGL 317
             PL+  Y    ++ + LS + TV +  +
Sbjct: 299 VVPLVGEYLLFTMIFVTLSIVVTVFVLNI 327


>gi|11138123 cholinergic receptor, nicotinic, alpha 10 [Homo
           sapiens]
          Length = 450

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 62/274 (22%), Positives = 120/274 (43%), Gaps = 22/274 (8%)

Query: 60  LLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTP 118
           L V + V +S + ++D     ++  L +R  W D  L W+ +A+    AI +P   +W P
Sbjct: 55  LNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRP 114

Query: 119 RLTILEALWVDWRDQSPQARVD------QDGHVKLNLALATETNCNFELLHFPRDHSNCS 172
            + +         D  P            DG V+ +    T ++C  ++  FP D  +C 
Sbjct: 115 DIVLYNKA-----DAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCG 169

Query: 173 LSFYALSNTAMELEFQ-----AHVVNEIVSVKREYVVYDLKTQVPP----QQLVPCFQVT 223
           L+F + ++   +L+ +     A + + + +V+   +    + +V       +  P    T
Sbjct: 170 LTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFT 229

Query: 224 LRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQAL 283
           L L+  A   +  LL+P   + L       LP  + E++   VT+LL+  V    L +++
Sbjct: 230 LLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESM 289

Query: 284 PSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGL 317
           P + S  PL+  Y+   + ++  ST  T+L+  L
Sbjct: 290 PPAESV-PLIGKYYMATMTMVTFSTALTILIMNL 322


>gi|70995130 cholinergic receptor, nicotinic, alpha 9 precursor
           [Homo sapiens]
          Length = 479

 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 65/312 (20%), Positives = 137/312 (43%), Gaps = 28/312 (8%)

Query: 37  LFNVNLSKKVQESIQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRL 96
           LFN +L +    +++   +    L V +++ +S + ++D     +++ L +R  W D  L
Sbjct: 34  LFN-DLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYL 92

Query: 97  AWNTSAHPR-HAITLPWESLWTPRLTILEALWVDWRDQSP---QARVDQDGHVKLNLALA 152
            W+   +    +I +P + +W P + +      D     P      +  DG +  +    
Sbjct: 93  TWDRDQYDGLDSIRIPSDLVWRPDIVLYNK--ADDESSEPVNTNVVLRYDGLITWDAPAI 150

Query: 153 TETNCNFELLHFPRDHSNCSLSFYALSNTAMELEFQAHVVNEIVSVKREYVVYDLKTQVP 212
           T+++C  ++ +FP D+  C+L+F + +    +++    + N + S      + D++ +V 
Sbjct: 151 TKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVD----IFNALDSGDLSDFIEDVEWEVH 206

Query: 213 PQQLV-------------PCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAI 259
               V             P    TL LK  +   I+ LL+P   +         LP  + 
Sbjct: 207 GMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASG 266

Query: 260 ERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLA 319
           E++   VT+LL+  V    + + +P+S +  PL+  Y+   + L+  ST  T+++  +  
Sbjct: 267 EKVSLGVTILLAMTVFQLMVAEIMPASENV-PLIGKYYIATMALITASTALTIMVMNI-- 323

Query: 320 RGNLGAKSGPSP 331
               GA++ P P
Sbjct: 324 -HFCGAEARPVP 334


>gi|4502827 cholinergic receptor, nicotinic, alpha 4 subunit
           precursor [Homo sapiens]
          Length = 627

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 57/271 (21%), Positives = 121/271 (44%), Gaps = 11/271 (4%)

Query: 55  NGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWE 113
           N S  +LV   + ++ + +VD     M++ + ++  W D +L W+ + +    +I +P E
Sbjct: 57  NISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSE 116

Query: 114 SLWTPRLTILEALWVDWR-DQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCS 172
            +W P + +      D+      +A +  DG V+       +++C+ ++  FP D  NC+
Sbjct: 117 LIWRPDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCT 176

Query: 173 LSF--YALSNTAMELEFQAHVVNEIVSVKR-EYVVYDLKTQVPPQQLVPCFQV------T 223
           + F  +      ++L      V+++   +  E+V+ D       ++   C ++       
Sbjct: 177 MKFGSWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYA 236

Query: 224 LRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQAL 283
             ++   L   I L++P   +    V    LP    E+I   +++LLS  V    + + +
Sbjct: 237 FVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEII 296

Query: 284 PSSSSCNPLLIYYFTILLLLLFLSTIETVLL 314
           PS+S   PL+  Y    ++ + LS + TV +
Sbjct: 297 PSTSLVIPLIGEYLLFTMIFVTLSIVITVFV 327


>gi|33589827 cholinergic receptor, nicotinic, alpha 5 [Homo sapiens]
          Length = 468

 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 55/266 (20%), Positives = 111/266 (41%), Gaps = 14/266 (5%)

Query: 68  VSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTILEAL 126
           +S + +VD     M++ + L+  W+D +L WN   +     I +P +S+WTP + + +  
Sbjct: 80  ISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNA 139

Query: 127 WVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALSNTAMELE 186
              +   S +  +  +G V        +++C  ++  FP D  NCS+ F + +    +++
Sbjct: 140 DGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVD 199

Query: 187 FQAHVVNEIVSVKREY----------VVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIA 236
               ++ +    KR++                 +       P    +  +K   L   + 
Sbjct: 200 I---ILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLF 256

Query: 237 LLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYY 296
           L++P   L    V    LP    E+I    ++L+S  V    + + +PSSS   PL+  Y
Sbjct: 257 LIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEY 316

Query: 297 FTILLLLLFLSTIETVLLAGLLARGN 322
               ++ + LS + TV    +  R +
Sbjct: 317 LVFTMIFVTLSIMVTVFAINIHHRSS 342


>gi|41327726 nicotinic acetylcholine receptor beta 1 subunit
           precursor [Homo sapiens]
          Length = 501

 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 63/286 (22%), Positives = 122/286 (42%), Gaps = 37/286 (12%)

Query: 62  VDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRL 120
           V V + ++ + +++     MS+ + L L W D RL+W+ + H    ++ +  ES+W P +
Sbjct: 54  VSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDV 113

Query: 121 TILEALWVDWRDQSPQARVD------QDGHVKLNLALATETNCNFELLHFPRDHSNCSLS 174
            +L        D +    +D       DG V+        ++C+ ++ +FP D  NC++ 
Sbjct: 114 VLLNN-----NDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMV 168

Query: 175 FYALSNTAMELEFQA--------------HVVNEIVSVKREYVVYDLKTQVPP------- 213
           F + S  + E+  Q               H    I + + E +    +   PP       
Sbjct: 169 FSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGR 228

Query: 214 --QQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLS 271
             Q+    F + +R K   L  ++ ++ P   + L  +    LP  A E++G  +  LL+
Sbjct: 229 EGQRQEVIFYLIIRRK--PLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLT 286

Query: 272 YLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGL 317
             V    L   +P +S   P++I Y    ++L+  S I +V++  L
Sbjct: 287 LTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNL 332


>gi|4557457 nicotinic cholinergic receptor alpha 1 isoform b
           precursor [Homo sapiens]
          Length = 457

 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 65/273 (23%), Positives = 114/273 (41%), Gaps = 28/273 (10%)

Query: 62  VDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRL 120
           V V + +  + NVD +   +++ + L+  W+D  L WN   +     I +P E +W P L
Sbjct: 51  VTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDL 110

Query: 121 TILEALWVDWRD-QSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSF---- 175
            +      D+   +  +  +   GH+        ++ C   + HFP D  NCS+      
Sbjct: 111 VLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWT 170

Query: 176 YALSNTAME-----------LEFQAHVVNEIVSVKREYVVYDLKTQVPPQQLVPCFQVTL 224
           Y  S  A+            +E    V+ E    K   V Y      P   +   F    
Sbjct: 171 YDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHS-VTYSCCPDTPYLDITYHFV--- 226

Query: 225 RLKNTALKSIIALLVPAEALLLADVCGGL---LPLRAIERIGYKVTLLLSYLVLHSSLVQ 281
            ++   L  I+ +++P    LL     GL   LP  + E++   +++LLS  V    +V+
Sbjct: 227 -MQRLPLYFIVNVIIPC---LLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVE 282

Query: 282 ALPSSSSCNPLLIYYFTILLLLLFLSTIETVLL 314
            +PS+SS  PL+  Y    ++ +  S I TV++
Sbjct: 283 LIPSTSSAVPLIGKYMLFTMVFVIASIIITVIV 315


>gi|153792669 cholinergic receptor, nicotinic, alpha polypeptide 2
           (neuronal) [Homo sapiens]
          Length = 529

 Score = 59.3 bits (142), Expect = 6e-09
 Identities = 56/273 (20%), Positives = 118/273 (43%), Gaps = 15/273 (5%)

Query: 55  NGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWN-TSAHPRHAITLPWE 113
           N S  ++V   + ++ + +VD     M++ + L+  W D +L WN T      ++ +P E
Sbjct: 79  NTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWSDYKLRWNPTDFGNITSLRVPSE 138

Query: 114 SLWTPRLTILEALWVDWR-DQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCS 172
            +W P + +      ++      +A +   G V        +++C+ ++  FP D  NC 
Sbjct: 139 MIWIPDIVLYNNADGEFAVTHMTKAHLFSTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCK 198

Query: 173 LSFYALSNTAMELEFQAHVVNEIVSVKR-----EYVV------YDLKTQVPPQQLVPCFQ 221
           + F + +    +++ +   + + V +K      E+ +      Y+ K      ++ P   
Sbjct: 199 MKFGSWTYDKAKIDLEQ--MEQTVDLKDYWESGEWAIVNATGTYNSKKYDCCAEIYPDVT 256

Query: 222 VTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQ 281
               ++   L   I L++P   +    V    LP    E+I   +++LLS  V    + +
Sbjct: 257 YAFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSDCGEKITLCISVLLSLTVFLLLITE 316

Query: 282 ALPSSSSCNPLLIYYFTILLLLLFLSTIETVLL 314
            +PS+S   PL+  Y    ++ + LS + TV +
Sbjct: 317 IIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFV 349


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score = 58.9 bits (141), Expect = 8e-09
 Identities = 70/318 (22%), Positives = 119/318 (37%), Gaps = 52/318 (16%)

Query: 53  PNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPW 112
           PN G AP+ V + ++V+++  +  +    +  +    +W D+RLA+  +           
Sbjct: 76  PNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETTLNLTLDYRMH 135

Query: 113 ESLWTPRLTILEALWVDWRDQSPQARVDQ---DGHVKLNLALATETNCNFELLHFPRDHS 169
           E LW P    L +      D + + RV Q   DG V+  + L T   C+ +L  FP D  
Sbjct: 136 EKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLHKFPMDKQ 195

Query: 170 NCSL-------------SFYALSNTAMELEFQAHV-----------VNEIVSVKREYVVY 205
            C+L              F+  +  A+ +  + H+             E+      Y+  
Sbjct: 196 ACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLGRTITSKEVYFYTGSYIRL 255

Query: 206 DLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYK 265
            LK QV  +      QV      T + S I+  +  ++              +  R+   
Sbjct: 256 ILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDS--------------SAARVTIG 301

Query: 266 VTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGLLARGNLGA 325
           +T +L    + S L   LP + SC   +  Y  + L  +FLS +E V +  L        
Sbjct: 302 LTSMLILTTIDSHLRDKLP-NISCIKAIDIYILVCLFFVFLSLLEYVYINYLFY------ 354

Query: 326 KSGPSPAPRGEQREHGNP 343
               S  PR + R H  P
Sbjct: 355 ----SRGPRRQPRRHRRP 368


>gi|4502833 neuronal nicotinic acetylcholine receptor beta 2
           precursor [Homo sapiens]
          Length = 502

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 56/271 (20%), Positives = 112/271 (41%), Gaps = 8/271 (2%)

Query: 50  IQIPNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAI 108
           I+   NGS  + V + V ++ + +V      M++ + L   W D RL W          +
Sbjct: 46  IRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEEFDNMKKV 105

Query: 109 TLPWESLWTPRLTILE-ALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRD 167
            LP + +W P + +   A  +        A V  DG +        ++ C  E+ HFP D
Sbjct: 106 RLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFD 165

Query: 168 HSNCSLSF--YALSNTAMELEFQAHVVN-EIVSVKREYVVYDL---KTQVPPQQLVPCFQ 221
             NC++ F  +    T ++L  ++ V + +  +   E+ +  L   + + P         
Sbjct: 166 QQNCTMKFRSWTYDRTEIDLVLKSEVASLDDFTPSGEWDIVALPGRRNENPDDSTYVDIT 225

Query: 222 VTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQ 281
               ++   L   I L++P   +    +    LP    E++   +++LL+  V    + +
Sbjct: 226 YDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISK 285

Query: 282 ALPSSSSCNPLLIYYFTILLLLLFLSTIETV 312
            +P +S   PL+  Y    ++L+  S + +V
Sbjct: 286 IVPPTSLDVPLVGKYLMFTMVLVTFSIVTSV 316


>gi|87567783 nicotinic cholinergic receptor alpha 1 isoform a
           precursor [Homo sapiens]
          Length = 482

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 59/244 (24%), Positives = 99/244 (40%), Gaps = 28/244 (11%)

Query: 91  WLDTRLAWNTSAHPR-HAITLPWESLWTPRLTILEALWVDWRD-QSPQARVDQDGHVKLN 148
           W+D  L WN   +     I +P E +W P L +      D+   +  +  +   GH+   
Sbjct: 105 WVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWT 164

Query: 149 LALATETNCNFELLHFPRDHSNCSLSF----YALSNTAME-----------LEFQAHVVN 193
                ++ C   + HFP D  NCS+      Y  S  A+            +E    V+ 
Sbjct: 165 PPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIK 224

Query: 194 EIVSVKREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGL 253
           E    K   V Y      P   +   F     ++   L  I+ +++P    LL     GL
Sbjct: 225 ESRGWKHS-VTYSCCPDTPYLDITYHFV----MQRLPLYFIVNVIIPC---LLFSFLTGL 276

Query: 254 ---LPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIE 310
              LP  + E++   +++LLS  V    +V+ +PS+SS  PL+  Y    ++ +  S I 
Sbjct: 277 VFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIII 336

Query: 311 TVLL 314
           TV++
Sbjct: 337 TVIV 340


>gi|23312388 CHRNA7-FAM7A fusion isoform 1 [Homo sapiens]
          Length = 412

 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 46/188 (24%), Positives = 87/188 (46%), Gaps = 17/188 (9%)

Query: 139 VDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSF-------YALSNTAMELEFQAHV 191
           V+  GH +       +++C  ++  FP D  +C L F       ++L     E +   ++
Sbjct: 42  VNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYI 101

Query: 192 VN---EIVSV--KREYVVYDLKTQVPPQQLVPCFQVTLRLKNTALKSIIALLVPAEALLL 246
            N   ++V +  KR    Y+   +  P      F VT+R +   L   + LL+P   +  
Sbjct: 102 PNGEWDLVGIPGKRSERFYECCKEPYPDVT---FTVTMRRRT--LYYGLNLLIPCVLISA 156

Query: 247 ADVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFL 306
             +   LLP  + E+I   +T+LLS  V    + + +P++S   PL+  YF   ++++ L
Sbjct: 157 LALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGL 216

Query: 307 STIETVLL 314
           S + TV++
Sbjct: 217 SVVVTVIV 224


>gi|4502837 cholinergic receptor, nicotinic, beta 4 [Homo sapiens]
          Length = 498

 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 64/305 (20%), Positives = 132/305 (43%), Gaps = 13/305 (4%)

Query: 19  LLLVHGQGFQGTAAIWPSLFNVNLSKKVQESIQIPNNGSAPLL-VDVRVFVSNVFNVDIL 77
           L+ + G+G    A     L +  L+K    ++  P   S+ L+ + +++ ++ + +V+  
Sbjct: 12  LVALCGRGNCRVANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIKLQLSLAQLISVNER 71

Query: 78  RYTMSSMLLLRLSWLDTRLAWNTSAHPR-HAITLPWESLWTPRLTILEALWVDWR-DQSP 135
              M++ + L+  W D RL WN+S +   + + +P + +W P + +       +      
Sbjct: 72  EQIMTTNVWLKQEWTDYRLTWNSSRYEGVNILRIPAKRIWLPDIVLYNNADGTYEVSVYT 131

Query: 136 QARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALSNTAMELEF-----QAH 190
              V  +G V        ++ C  E+ +FP D  NC+L F + +    E++       A 
Sbjct: 132 NLIVRSNGSVLWLPPAIYKSACKIEVKYFPFDQQNCTLKFRSWTYDHTEIDMVLMTPTAS 191

Query: 191 VVNEIVSVKREYVVYDLKTQVPPQQLVPCF-QVT--LRLKNTALKSIIALLVPAEALLLA 247
           + +   S + + V    +  V PQ   P +  VT    +K   L   I L++P     L 
Sbjct: 192 MDDFTPSGEWDIVALPGRRTVNPQD--PSYVDVTYDFIIKRKPLFYTINLIIPCVLTTLL 249

Query: 248 DVCGGLLPLRAIERIGYKVTLLLSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLS 307
            +    LP    E++   +++LL+       + + +P +S   PL+  Y    ++L+  S
Sbjct: 250 AILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDVPLIGKYLMFTMVLVTFS 309

Query: 308 TIETV 312
            + +V
Sbjct: 310 IVTSV 314


>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
           precursor [Homo sapiens]
          Length = 452

 Score = 52.4 bits (124), Expect = 8e-07
 Identities = 53/272 (19%), Positives = 114/272 (41%), Gaps = 15/272 (5%)

Query: 53  PNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPW 112
           P  G  P+ V + + V+++ ++       +  + L  SW D+RL++N +       +   
Sbjct: 57  PGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFV 116

Query: 113 ESLWTPRLTILEALWVDWRD---QSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHS 169
           + LW P   I+ A    + D   ++   R+  DG +  ++ + +   C+ +L  +P D  
Sbjct: 117 DKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQ 176

Query: 170 NCSLSFYALSNTAMEL-----EFQAHV--VNEIVSVKREYVVYDLKTQV---PPQQLVPC 219
            C L   +   ++ ++     E Q H+  ++++   +     Y   T++         P 
Sbjct: 177 ECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAGQFPR 236

Query: 220 FQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAI-ERIGYKVTLLLSYLVLHSS 278
             +   L+      II   +P+  L+        +   A+  R+   +T +L+   L  S
Sbjct: 237 LSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVS 296

Query: 279 LVQALPSSSSCNPLLIYYFTILLLLLFLSTIE 310
              +LP +S+   L + YF I  + +F + +E
Sbjct: 297 ARSSLPRASAIKALDV-YFWICYVFVFAALVE 327


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 55/274 (20%), Positives = 111/274 (40%), Gaps = 19/274 (6%)

Query: 53  PNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLP- 111
           PN    P+ V   +F+++  +V          + LR  W D+RLA+  S +P  ++ L  
Sbjct: 64  PNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAY--SEYPDDSLDLDP 121

Query: 112 --WESLWTPRLTILEALWVDWRDQSPQ---ARVDQDGHVKLNLALATETNCNFELLHFPR 166
              +S+W P L        ++ D +      R+ ++G V  ++ L    +C  +L +FP 
Sbjct: 122 SMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPM 181

Query: 167 DHSNCSLSFYALSNTAMELEFQ---------AHVVNEIVSVKREYVVYDLKTQVPPQQLV 217
           D   C++   +   T  +L F+         A  +     + +E       T+       
Sbjct: 182 DVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKF 241

Query: 218 PCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAI-ERIGYKVTLLLSYLVLH 276
            C +V   L+      +I + +P+  +++       + + A   R+   +T +L+     
Sbjct: 242 TCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS 301

Query: 277 SSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIE 310
           S    +LP  S    + I +  + LL +F + +E
Sbjct: 302 SGSRASLPKVSYVKAIDI-WMAVCLLFVFAALLE 334


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 55/274 (20%), Positives = 111/274 (40%), Gaps = 19/274 (6%)

Query: 53  PNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLP- 111
           PN    P+ V   +F+++  +V          + LR  W D+RLA+  S +P  ++ L  
Sbjct: 64  PNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAY--SEYPDDSLDLDP 121

Query: 112 --WESLWTPRLTILEALWVDWRDQSPQ---ARVDQDGHVKLNLALATETNCNFELLHFPR 166
              +S+W P L        ++ D +      R+ ++G V  ++ L    +C  +L +FP 
Sbjct: 122 SMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPM 181

Query: 167 DHSNCSLSFYALSNTAMELEFQ---------AHVVNEIVSVKREYVVYDLKTQVPPQQLV 217
           D   C++   +   T  +L F+         A  +     + +E       T+       
Sbjct: 182 DVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKF 241

Query: 218 PCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAI-ERIGYKVTLLLSYLVLH 276
            C +V   L+      +I + +P+  +++       + + A   R+   +T +L+     
Sbjct: 242 TCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS 301

Query: 277 SSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIE 310
           S    +LP  S    + I +  + LL +F + +E
Sbjct: 302 SGSRASLPKVSYVKAIDI-WMAVCLLFVFAALLE 334


>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
           [Homo sapiens]
          Length = 465

 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 32/141 (22%), Positives = 63/141 (44%), Gaps = 7/141 (4%)

Query: 53  PNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPW 112
           P+ G  P +++  V+V+++  VD +    +  ++   +W D+RL +N++       +   
Sbjct: 81  PDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMV 140

Query: 113 ESLWTPRLTIL-----EALWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRD 167
             +W P          +A W+   ++    R+  DG V   L L     C  +L +FP D
Sbjct: 141 GKIWIPDTFFRNSRKSDAHWITTPNRL--LRIWNDGRVLYTLRLTINAECYLQLHNFPMD 198

Query: 168 HSNCSLSFYALSNTAMELEFQ 188
             +C L F +      E+E++
Sbjct: 199 EHSCPLEFSSYGYPKNEIEYK 219


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 54/274 (19%), Positives = 111/274 (40%), Gaps = 19/274 (6%)

Query: 53  PNNGSAPLLVDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLP- 111
           PN    P+ V   +F+++  ++          + LR  W D+RLA+  S +P  ++ L  
Sbjct: 64  PNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQQWNDSRLAY--SEYPDDSLDLDP 121

Query: 112 --WESLWTPRLTILEALWVDWRDQSPQ---ARVDQDGHVKLNLALATETNCNFELLHFPR 166
              +S+W P L        ++ D +      R+ ++G V  ++ L    +C  +L +FP 
Sbjct: 122 SMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPM 181

Query: 167 DHSNCSLSFYALSNTAMELEFQ---------AHVVNEIVSVKREYVVYDLKTQVPPQQLV 217
           D   C++   +   T  +L F+         A  +     + +E       T+       
Sbjct: 182 DVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKF 241

Query: 218 PCFQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAI-ERIGYKVTLLLSYLVLH 276
            C +V   L+      +I + +P+  +++       + + A   R+   +T +L+     
Sbjct: 242 TCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS 301

Query: 277 SSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIE 310
           S    +LP  S    + I +  + LL +F + +E
Sbjct: 302 SGSRASLPKVSYVKAIDI-WMAVCLLFVFAALLE 334


>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
           precursor [Homo sapiens]
          Length = 490

 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 66/281 (23%), Positives = 123/281 (43%), Gaps = 46/281 (16%)

Query: 59  PLLVDVRV-FVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAITLPW---ES 114
           P+ VDV+V  + ++  VD + +TM+  L LR  W D RLA++++++   ++T      + 
Sbjct: 103 PVGVDVQVESLDSISEVD-MDFTMT--LYLRHYWKDERLAFSSASNK--SMTFDGRLVKK 157

Query: 115 LWTPRLTILEA---LWVDWRDQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNC 171
           +W P +  + +      D    +   RV  DGHV  ++ +     CN +  HFP D   C
Sbjct: 158 IWVPDVFFVHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTC 217

Query: 172 SLSFYALSNTAMELEFQAHVVNEIVSVKR---EYVVYDLKTQVPPQQLVPCFQVTLRLK- 227
           SL          ELE  A+   +++   +   E +  D K  +  Q L+  F  T RL  
Sbjct: 218 SL----------ELESYAYTDEDLMLYWKNGDESLKTDEKISL-SQFLIQKFHTTSRLAF 266

Query: 228 ------------NTALKS-----IIALLVPAEALLLADVCGGLLPLRAI-ERIGYKVTLL 269
                       N  L+      ++    PA  +++       +  RA+  R+   +T +
Sbjct: 267 YSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTV 326

Query: 270 LSYLVLHSSLVQALPSSSSCNPLLIYYFTILLLLLFLSTIE 310
           L+   + + +  ++P  S    + IY + +  + +FLS +E
Sbjct: 327 LTMTTIITGVNASMPRVSYVKAVDIYLW-VSFVFVFLSVLE 366


>gi|4557461 nicotinic acetylcholine receptor delta polypeptide
           precursor [Homo sapiens]
          Length = 517

 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 58/280 (20%), Positives = 116/280 (41%), Gaps = 24/280 (8%)

Query: 62  VDVRVFVSNVFNVDILRYTMSSMLLLRLSWLDTRLAWNTSAHPRHAIT-LPWESLWTPRL 120
           V + + +SN+ ++  +  T+++ + +   W D RL WN       ++  LP + +W P +
Sbjct: 54  VALALTLSNLISLKEVEETLTTNVWIEHGWTDNRLKWNAEEFGNISVLRLPPDMVWLPEI 113

Query: 121 TILEALWVDWR-DQSPQARVDQDGHVKLNLALATETNCNFELLHFPRDHSNCSLSFYALS 179
            +       ++   S    V   G V         ++C   + +FP D  NCSL F +L 
Sbjct: 114 VLENNNDGSFQISYSCNVLVYHYGFVYWLPPAIFRSSCPISVTYFPFDWQNCSLKFSSLK 173

Query: 180 NTAMEL---------EFQAHVVNEIV--------SVKREYVVYDLKTQVPPQQLVPC--- 219
            TA E+         E + + V  I+        + + E V    +  V P+  +     
Sbjct: 174 YTAKEITLSLKQDAKENRTYPVEWIIIDPEGFTENGEWEIVHRPARVNVDPRAPLDSPSR 233

Query: 220 --FQVTLRLKNTALKSIIALLVPAEALLLADVCGGLLPLRAIERIGYKVTLLLSYLVLHS 277
                 L ++   L  II +LVP   +         LP  + E+    +++LL+  V   
Sbjct: 234 QDITFYLIIRRKPLFYIINILVPCVLISFMVNLVFYLPADSGEKTSVAISVLLAQSVFLL 293

Query: 278 SLVQALPSSSSCNPLLIYYFTILLLLLFLSTIETVLLAGL 317
            + + LP++S   PL+  +    ++L+ +  +  V++  +
Sbjct: 294 LISKRLPATSMAIPLIGKFLLFGMVLVTMVVVICVIVLNI 333


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,260,125
Number of Sequences: 37866
Number of extensions: 740068
Number of successful extensions: 3593
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 3348
Number of HSP's gapped (non-prelim): 249
length of query: 412
length of database: 18,247,518
effective HSP length: 105
effective length of query: 307
effective length of database: 14,271,588
effective search space: 4381377516
effective search space used: 4381377516
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.