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Search of human proteins with 206597515
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
(1133 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 2285 0.0
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 1572 0.0
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 1572 0.0
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 724 0.0
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 422 e-118
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 100 1e-20
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 99 2e-20
gi|194272142 myosin IXB isoform 2 [Homo sapiens] 97 7e-20
gi|33356170 myosin IXB isoform 1 [Homo sapiens] 97 7e-20
gi|156119615 myosin IXA [Homo sapiens] 97 9e-20
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 96 2e-19
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 96 2e-19
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 95 4e-19
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 92 2e-18
gi|188497642 ARHGAP15 [Homo sapiens] 92 4e-18
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] 91 6e-18
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 91 6e-18
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 91 6e-18
gi|56119110 family with sequence similarity 13, member A1 isofor... 91 8e-18
gi|208022687 GTPase regulator associated with the focal adhesion... 88 4e-17
gi|7662208 GTPase regulator associated with the focal adhesion k... 88 4e-17
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 87 1e-16
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 87 1e-16
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 86 2e-16
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 86 2e-16
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 86 3e-16
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 86 3e-16
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 85 4e-16
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 85 4e-16
gi|5803145 ralA binding protein 1 [Homo sapiens] 84 8e-16
>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform d [Homo sapiens]
Length = 1133
Score = 2285 bits (5921), Expect = 0.0
Identities = 1133/1133 (100%), Positives = 1133/1133 (100%)
Query: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
Sbjct: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
Query: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
Sbjct: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
Query: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
Sbjct: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
Query: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
Sbjct: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
Query: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
Sbjct: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
Query: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL 360
PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL
Sbjct: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL 360
Query: 361 CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR 420
CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR
Sbjct: 361 CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR 420
Query: 421 LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN 480
LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN
Sbjct: 421 LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN 480
Query: 481 ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA 540
ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA
Sbjct: 481 ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA 540
Query: 541 KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL 600
KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL
Sbjct: 541 KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL 600
Query: 601 RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG 660
RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG
Sbjct: 601 RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG 660
Query: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720
DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD
Sbjct: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720
Query: 721 VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780
VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI
Sbjct: 721 VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780
Query: 781 SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840
SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL
Sbjct: 781 SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840
Query: 841 RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI 900
RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI
Sbjct: 841 RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI 900
Query: 901 LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML 960
LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML
Sbjct: 901 LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML 960
Query: 961 LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW 1020
LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW
Sbjct: 961 LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW 1020
Query: 1021 PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD 1080
PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD
Sbjct: 1021 PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD 1080
Query: 1081 GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV 1133
GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV
Sbjct: 1081 GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV 1133
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform a [Homo sapiens]
Length = 1205
Score = 1572 bits (4071), Expect = 0.0
Identities = 819/1022 (80%), Positives = 863/1022 (84%), Gaps = 78/1022 (7%)
Query: 132 ISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVP 191
+ +V + + F++ T R F+F A+S++E+++W++A+Q A+AE + + ++ P
Sbjct: 242 VGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAP 301
Query: 192 -------GSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGN 244
G+ QPD A + V + K H G+G V
Sbjct: 302 NRFCADCGAPQPDWAS---------------INLCVVICKRCAGEHRGLGA-----GVSK 341
Query: 245 VKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAA--APN 302
V+ + +++++ W E + + + R WAA P+
Sbjct: 342 VRSL--------------------KMDRKVWTETLIELFLQL--GNGAGNRFWAANVPPS 379
Query: 303 RFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEALCA 362
+P S C + K G++R + L ++ E L +ALCA
Sbjct: 380 EALQPSSSP-----STRRCHLEAKYREGKYR-------RYHPLFGNQ----EELDKALCA 423
Query: 363 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 422
AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD
Sbjct: 424 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 483
Query: 423 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 482
SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER
Sbjct: 484 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 543
Query: 483 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 542
AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA
Sbjct: 544 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 603
Query: 543 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 602
FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK
Sbjct: 604 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 663
Query: 603 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 662
LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS
Sbjct: 664 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 723
Query: 663 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 722
DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS
Sbjct: 724 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 783
Query: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH
Sbjct: 784 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 843
Query: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 842
LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK
Sbjct: 844 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 903
Query: 843 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 902
QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD
Sbjct: 904 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 963
Query: 903 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 962
RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY
Sbjct: 964 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 1023
Query: 963 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR---------- 1012
LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR
Sbjct: 1024 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPE 1083
Query: 1013 -SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1071
SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF
Sbjct: 1084 TSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1143
Query: 1072 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1131
ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR
Sbjct: 1144 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1203
Query: 1132 NV 1133
NV
Sbjct: 1204 NV 1205
Score = 728 bits (1880), Expect = 0.0
Identities = 358/358 (100%), Positives = 358/358 (100%)
Query: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
Sbjct: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
Query: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
Sbjct: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
Query: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
Sbjct: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
Query: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
Sbjct: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
Query: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
Sbjct: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
Query: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE
Sbjct: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
isoform c [Homo sapiens]
Length = 1450
Score = 1572 bits (4071), Expect = 0.0
Identities = 819/1022 (80%), Positives = 863/1022 (84%), Gaps = 78/1022 (7%)
Query: 132 ISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVP 191
+ +V + + F++ T R F+F A+S++E+++W++A+Q A+AE + + ++ P
Sbjct: 487 VGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAP 546
Query: 192 -------GSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGN 244
G+ QPD A + V + K H G+G V
Sbjct: 547 NRFCADCGAPQPDWAS---------------INLCVVICKRCAGEHRGLGA-----GVSK 586
Query: 245 VKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAA--APN 302
V+ + +++++ W E + + + R WAA P+
Sbjct: 587 VRSL--------------------KMDRKVWTETLIELFLQL--GNGAGNRFWAANVPPS 624
Query: 303 RFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEALCA 362
+P S C + K G++R + L ++ E L +ALCA
Sbjct: 625 EALQPSSSP-----STRRCHLEAKYREGKYR-------RYHPLFGNQ----EELDKALCA 668
Query: 363 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 422
AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD
Sbjct: 669 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 728
Query: 423 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 482
SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER
Sbjct: 729 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 788
Query: 483 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 542
AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA
Sbjct: 789 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 848
Query: 543 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 602
FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK
Sbjct: 849 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 908
Query: 603 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 662
LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS
Sbjct: 909 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 968
Query: 663 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 722
DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS
Sbjct: 969 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 1028
Query: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH
Sbjct: 1029 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 1088
Query: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 842
LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK
Sbjct: 1089 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 1148
Query: 843 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 902
QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD
Sbjct: 1149 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 1208
Query: 903 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 962
RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY
Sbjct: 1209 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 1268
Query: 963 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR---------- 1012
LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR
Sbjct: 1269 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPE 1328
Query: 1013 -SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1071
SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF
Sbjct: 1329 TSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1388
Query: 1072 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1131
ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR
Sbjct: 1389 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1448
Query: 1132 NV 1133
NV
Sbjct: 1449 NV 1450
Score = 728 bits (1880), Expect = 0.0
Identities = 358/358 (100%), Positives = 358/358 (100%)
Query: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
Sbjct: 246 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 305
Query: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
Sbjct: 306 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 365
Query: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
Sbjct: 366 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 425
Query: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
Sbjct: 426 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 485
Query: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
Sbjct: 486 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 545
Query: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE
Sbjct: 546 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 603
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
[Homo sapiens]
Length = 1704
Score = 724 bits (1869), Expect = 0.0
Identities = 427/1131 (37%), Positives = 633/1131 (55%), Gaps = 117/1131 (10%)
Query: 84 IKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKF 143
+K+GWLDK PQG ++QKRWV+ D + Y+++ K+ YSK I ++ IS V GD KF
Sbjct: 484 VKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKF 543
Query: 144 EVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLE 203
EV+T RTF FR E + ER +W+ L A+ Q ++ + P++ G LE
Sbjct: 544 EVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVT--------PEKCGYLE 595
Query: 204 LRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDR---RSFDLTTPYR 260
LRG+K K++ + G+ V L KN +++ G+GIT I M+V NVK+VDR +SF++ TPYR
Sbjct: 596 LRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYR 655
Query: 261 IFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPD------ 314
FSF+A++E EK+ W+EA+Q +IAE LS EVAE+IW NR CADC AP PD
Sbjct: 656 SFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINL 715
Query: 315 -------------------------------WAS--INLCVVICKRCAGEHRGLGAGVSK 341
W++ I L +VI + A + + K
Sbjct: 716 CVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDF--WAGNLQK 773
Query: 342 VRSLKMDRKV------------------------WTETLIEALCAAVTTTDLAETQALLG 377
L MD V E L +ALCAAV D+ ET ALL
Sbjct: 774 DEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLF 833
Query: 378 CGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPT 437
GA + C +GDP TP LA++AGQ+LQMEFL +N+ ++ P+ D H VL
Sbjct: 834 SGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDI------HSEGVLSQ 887
Query: 438 VSHSG-----FLYKTASAG-KLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIR 491
S FLY+ SA KL +++ EE +++WCVL G LSY+EN+++ TPNG I
Sbjct: 888 ESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTIN 947
Query: 492 ASEIVCLAVPPPDTH---GFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLA 548
+E++CLA+ D + G FE+Y ER++LFG E+++ +W + IAK FVP A
Sbjct: 948 INEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFA 1007
Query: 549 EDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE-EPLQLRKLQELS 607
E+L D++ +G+L YK +L + ++GWF++ S L + + + LR+LQEL+
Sbjct: 1008 ENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELT 1067
Query: 608 I----QGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSD 663
I Q + VL+LVE+ RTLYI G +LDF W AI+KAA + G+ L +QQL +D
Sbjct: 1068 ISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKND 1127
Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
+P+IV C+ ++TQ GL + IY+K G LLES ++DARS L+ G+ ++DV++
Sbjct: 1128 VPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTA 1187
Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
LK FL D+ D L T+ W+ A + +D++E++ +Y + LP VNRAT+ A+I HL
Sbjct: 1188 VLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHL 1247
Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQ 843
Y VQ S+ N MN HNLA+VF LFQT GQ + V+EDLIN+YV +F V E+++++
Sbjct: 1248 YRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQM 1307
Query: 844 REEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDR 903
E + I K + + AGD + VY+E K+ + I++ M AEELT +IL
Sbjct: 1308 DIENSFITKWK----DTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAI 1363
Query: 904 RNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGT-----DSHLVVKKHQAMEA 958
+N+ + D W FEV E EE ERPLH+ E VL + + ++LVVK+ +
Sbjct: 1364 KNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADT 1423
Query: 959 ML-LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPE 1017
+ S +G K G++K +E+ S + L F DRYF+L L LYK+V+S + +
Sbjct: 1424 IKHCSDRSTLGSIKEGILKIKEEPSKI---LSGNKFQDRYFVLRDGFLFLYKDVKSSKHD 1480
Query: 1018 KEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFV 1077
K + + S+K Y GVKKK++PPT WG T EK W+LCCD+ EW +
Sbjct: 1481 KMFSLSSMKFYRGVKKKMKPPTSWGLTAY-----SEKHHWHLCCDSSRTQTEWMTSIFIA 1535
Query: 1078 QHDGLVWPSEPSRVSRAVPE-VRLGSVSLIPLR--GSENEMRRSVAAFTAD 1125
QH+ +WP R++ + ++G + LIP++ G+ R+++ + A+
Sbjct: 1536 QHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAE 1586
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
[Homo sapiens]
Length = 1544
Score = 422 bits (1086), Expect = e-118
Identities = 278/785 (35%), Positives = 406/785 (51%), Gaps = 68/785 (8%)
Query: 356 LIEALCAAVTTTDLAETQALLGCGAGINCFSGD----PEAPTPLALAEQAGQTLQMEFLR 411
L++ALCAAV +L + L C + F G+ P AP
Sbjct: 616 LLQALCAAVARPNLLKNMTQLLC---VEAFEGEEPWFPPAPDG----------------- 655
Query: 412 NNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKL--LQDRRAREEFSRRWCV 469
P L P Y+ V+ ++SGFLY + + K RR R+ R WCV
Sbjct: 656 -----SCPGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCV 710
Query: 470 LGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHG---FEHTFEVYTEGERLYLFGL 526
LG L F +E + P I+ +IVCL V PP T F +FE+ G R+ FG
Sbjct: 711 LG-AALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGT 769
Query: 527 ESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFS----LSG 582
+ A+ W + K F P LL RLGRL ++ A W S L G
Sbjct: 770 DGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRG 829
Query: 583 SELRAVFPEGPC----EEPLQLRKLQELSIQGDSEN----QVLVLVERRRTLYIQGERRL 634
L GP E+ + LR+LQE+S+ ++ + LVLVE RTLY+QGE RL
Sbjct: 830 DHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRL 889
Query: 635 DFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSK 694
DF W AI AA G L EQQ+ DIP+IV C+ ++TQ GL EG+YRK G ++
Sbjct: 890 DFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARAR 949
Query: 695 TQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDE 754
+ RLL R+DARSV L+ GE V+DV+ LKRF R+L D + + W EA+E+ +
Sbjct: 950 SLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQK 1009
Query: 755 EEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQ 814
+++ +Y++++ LP VNR T+ LI HLY VQ + NQM NLA++F P++FQTDG+
Sbjct: 1010 NQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGR 1069
Query: 815 DYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYL 874
RV+++LI+ Y+ VF +D +++ + E++ I + + AGD I VY+
Sbjct: 1070 GEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLS----QAGDLIMEVYI 1125
Query: 875 EEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEK 934
E++ + +KV ++TAEELT ++L+ R D W FE+ E E ERPLH EK
Sbjct: 1126 EQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTA-AGMDLWVTFEIREHGELERPLHPKEK 1184
Query: 935 VLP-----ILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFRED-RSLLGLGL 988
VL + L++KK +A L+ R + G+++ RE+ LLG
Sbjct: 1185 VLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLG--- 1241
Query: 989 PSGGFHDRYFILNSSCLRLYKEVRSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHE 1048
F +R+F+L CL L KE +S +PE+EWP++ KVYLG++KKL+PPT WGFT++
Sbjct: 1242 --SRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLI-- 1297
Query: 1049 TEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPL 1108
EK YL C + E+ +W + L QHD S + + G++ L+P+
Sbjct: 1298 ---LEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPI 1354
Query: 1109 RGSEN 1113
RG ++
Sbjct: 1355 RGDDS 1359
Score = 261 bits (666), Expect = 3e-69
Identities = 131/282 (46%), Positives = 185/282 (65%), Gaps = 13/282 (4%)
Query: 80 VTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIG 139
+TP++ +GWLDK PQG+Y++Q+R+V+ + L YF S+KD + K I + I +
Sbjct: 286 LTPLL-SGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSK 344
Query: 140 DQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDR- 198
D KF+VIT R F FR ES+ +R W LQ + EQR LLG P QP R
Sbjct: 345 DNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQR---------LLGHPRPPQPPRP 395
Query: 199 --AGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLT 256
G LELRG K K++ A+ ++ LYK+ + + LGIGI FI++ +V+E RSFDL
Sbjct: 396 LRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLL 455
Query: 257 TPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWA 316
TP+R FSF+A+S ++ W A+Q A+ E LS EVAE+IW+ NR CADCG+ +PDWA
Sbjct: 456 TPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWA 515
Query: 317 SINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
++NL VVICK+CAG+HR LG+G+SKV+SLK+D VW+ +++
Sbjct: 516 AVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQ 557
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 99.8 bits (247), Expect = 1e-20
Identities = 64/185 (34%), Positives = 98/185 (52%), Gaps = 9/185 (4%)
Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVS 722
+P+IV C + GL S GIYR G + L E L + ++L++ Q ++ +S
Sbjct: 825 VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVIS 884
Query: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
S LK F R LP+ LFT + ++EA+ IED E++ R+L+ LP T+K L+ H
Sbjct: 885 SLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGH 944
Query: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDY--------KAGRVVEDLINHYVVVFS 834
L + S+ N+M NLA+VFGPTL +T + ++VE LI H FS
Sbjct: 945 LKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFS 1004
Query: 835 VDEEE 839
+E++
Sbjct: 1005 DEEDK 1009
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 99.0 bits (245), Expect = 2e-20
Identities = 55/152 (36%), Positives = 84/152 (55%), Gaps = 1/152 (0%)
Query: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720
+ IP+ + RC++YI GL++EGIYR G S+ + L QD ++ L E + V+
Sbjct: 1258 EKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQD-HNLDLAEKDFTVNT 1316
Query: 721 VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780
V+ A+K F +LPD L ++ +EA +I D E+K+ +E+L + P N K +I
Sbjct: 1317 VAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVI 1376
Query: 781 SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812
SHL V + N M NL+I F PTL + D
Sbjct: 1377 SHLNKVSHNNKVNLMTSENLSICFWPTLMRPD 1408
>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
Length = 2022
Score = 97.4 bits (241), Expect = 7e-20
Identities = 57/196 (29%), Positives = 112/196 (57%), Gaps = 5/196 (2%)
Query: 662 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721
+ +P+++ + ++++ GL +EG+YRK G ++T+ L ++L+ D +V L+ H +
Sbjct: 1710 ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--I 1767
Query: 722 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781
+ LK++LR+LP+ L T AQ +L A E+ +++E+++ +L LP N +++ LI
Sbjct: 1768 TGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIF 1827
Query: 782 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840
HL V D N+M+ LAI+F P L + D D ++D++ V + +E++
Sbjct: 1828 HLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQM 1885
Query: 841 RKQREEITAIVKMRVA 856
RK + ++ I ++ A
Sbjct: 1886 RKYKVKMEEISQLEAA 1901
>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
Length = 2157
Score = 97.4 bits (241), Expect = 7e-20
Identities = 57/196 (29%), Positives = 112/196 (57%), Gaps = 5/196 (2%)
Query: 662 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721
+ +P+++ + ++++ GL +EG+YRK G ++T+ L ++L+ D +V L+ H +
Sbjct: 1710 ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--I 1767
Query: 722 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781
+ LK++LR+LP+ L T AQ +L A E+ +++E+++ +L LP N +++ LI
Sbjct: 1768 TGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIF 1827
Query: 782 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840
HL V D N+M+ LAI+F P L + D D ++D++ V + +E++
Sbjct: 1828 HLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQM 1885
Query: 841 RKQREEITAIVKMRVA 856
RK + ++ I ++ A
Sbjct: 1886 RKYKVKMEEISQLEAA 1901
>gi|156119615 myosin IXA [Homo sapiens]
Length = 2548
Score = 97.1 bits (240), Expect = 9e-20
Identities = 66/219 (30%), Positives = 114/219 (52%), Gaps = 5/219 (2%)
Query: 646 AAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQD 705
++ G LS D +P++V + ++YI GL +EGIYRK G T+K + L + L D
Sbjct: 2057 SSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTD 2116
Query: 706 ARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELL 765
A SV+L + HV ++S K++LRDLP+ L T +L A +++ +E + ++
Sbjct: 2117 AESVNLDDYNIHV--IASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVI 2174
Query: 766 VRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVED 824
+L + T++ LI HL + DTN+M+ + LAIVF P + + D D + V+D
Sbjct: 2175 DQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTD--PLQSVQD 2232
Query: 825 LINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQ 863
+ V + E++ K + + I + A + T+
Sbjct: 2233 ISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTR 2271
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 95.9 bits (237), Expect = 2e-19
Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 57/401 (14%)
Query: 437 TVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEI- 495
T+ +G L++T +A K R ++ +S W VL GVL++F++ + G + S+
Sbjct: 128 TLDKAGVLHRTKTADK--GKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFS 185
Query: 496 ----------VCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAK---- 541
L+ P D ++ E+ + YL +S W K IA+
Sbjct: 186 TPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQE 245
Query: 542 --AFVPPLAEDLLARDF---ERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPE-GPCE 595
A +PP + DF ERLG S Q +E + A P GP
Sbjct: 246 LSAELPPEESESSRVDFGSSERLG--------SWQEKEED------ARPNAAAPALGPVG 291
Query: 596 EPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLS 655
L K++ +++ ++RR TL E+ G A L
Sbjct: 292 LESDLSKVR---------HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA-------LC 335
Query: 656 EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE 715
E++ S +P V +C+ + GL +G+YR G + Q+L + D R + L +G
Sbjct: 336 ERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGR 392
Query: 716 -QHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 774
+ V ++ ALK F R+LP+ LF + ++ A +++D+ + R+L+ LP N
Sbjct: 393 WEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHD 452
Query: 775 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815
T++ L HL V + N+M+V ++AIVFGPTL + + ++
Sbjct: 453 TLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE 493
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 95.9 bits (237), Expect = 2e-19
Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 57/401 (14%)
Query: 437 TVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEI- 495
T+ +G L++T +A K R ++ +S W VL GVL++F++ + G + S+
Sbjct: 155 TLDKAGVLHRTKTADK--GKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFS 212
Query: 496 ----------VCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAK---- 541
L+ P D ++ E+ + YL +S W K IA+
Sbjct: 213 TPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQE 272
Query: 542 --AFVPPLAEDLLARDF---ERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPE-GPCE 595
A +PP + DF ERLG S Q +E + A P GP
Sbjct: 273 LSAELPPEESESSRVDFGSSERLG--------SWQEKEED------ARPNAAAPALGPVG 318
Query: 596 EPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLS 655
L K++ +++ ++RR TL E+ G A L
Sbjct: 319 LESDLSKVR---------HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA-------LC 362
Query: 656 EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE 715
E++ S +P V +C+ + GL +G+YR G + Q+L + D R + L +G
Sbjct: 363 ERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGR 419
Query: 716 -QHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 774
+ V ++ ALK F R+LP+ LF + ++ A +++D+ + R+L+ LP N
Sbjct: 420 WEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHD 479
Query: 775 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815
T++ L HL V + N+M+V ++AIVFGPTL + + ++
Sbjct: 480 TLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE 520
>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
Length = 698
Score = 94.7 bits (234), Expect = 4e-19
Identities = 86/304 (28%), Positives = 142/304 (46%), Gaps = 27/304 (8%)
Query: 575 EGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRL 634
+G+ SL G+++ + P GP E+P + L E+S G E + + L +R
Sbjct: 78 QGFISLQGTQVTEL-PPGP-EDPG--KHLFEISPGGAGEREKVPANPEALLLMASSQR-- 131
Query: 635 DFMGWLGAIQKAA-ASMGDTLSEQQL----------GDSDIPVIVYRCVDYITQCGLTSE 683
D W+ AI++ A +G + Q+L G P++V +CVD+I + GLT E
Sbjct: 132 DMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEE 191
Query: 684 GIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRL 743
G++R GQ + + L +S D L + V V+S LK +LR+LP+ + A+
Sbjct: 192 GLFRMPGQANLVRDLQDSF--DCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYE 249
Query: 744 TWLEASEI--EDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLA 801
+L +++ +DE E + + LP N ++ + L VQ +S+ N+M+V NLA
Sbjct: 250 DFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLA 309
Query: 802 IVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASG 861
VFGP + + +D L+ H + V +RK + TA V G
Sbjct: 310 TVFGPNILRPQVEDPVTIMEGTSLVQHLMTVL------IRKHSQLFTAPVPEGPTSPRGG 363
Query: 862 TQHA 865
Q A
Sbjct: 364 LQCA 367
Score = 38.9 bits (89), Expect = 0.028
Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 10/118 (8%)
Query: 450 AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFE 509
AG L + R + + +RW VL L Y++++ + P G I +PP +
Sbjct: 41 AGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGK 100
Query: 510 HTFEVYT--EGER--------LYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFE 557
H FE+ GER L S +WV+ I + PL + + E
Sbjct: 101 HLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQRLE 158
Score = 35.0 bits (79), Expect = 0.40
Identities = 29/111 (26%), Positives = 49/111 (44%), Gaps = 22/111 (19%)
Query: 82 PVIKAGWLDKNPPQGSYI--YQKRWVRLDTDHLRYFDSNKDAYSKRFISVACI------- 132
PV+KAGWL K Q S + +Q+RW L D L Y+ + + FIS+
Sbjct: 37 PVLKAGWLKK---QRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPP 93
Query: 133 ------SHVAAI----GDQKFEVITNNRTFAFRAESDVERKEWMQALQQAM 173
H+ I ++ +V N A S + ++W+QA+++ +
Sbjct: 94 GPEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 92.4 bits (228), Expect = 2e-18
Identities = 64/196 (32%), Positives = 102/196 (52%), Gaps = 11/196 (5%)
Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVS 722
IP+IV C + + GL GIYR G + + E L + + +++ + + ++ +S
Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220
Query: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
S LK F R LP+ LFT + ++EA+ ED +++ + L+ LP + T+K L +H
Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280
Query: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDY--------KAGRVVEDLINHYVVVFS 834
L V S+ N+M NLAIVFGPTL +T + ++VE LI H+ F+
Sbjct: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFT 1340
Query: 835 VD--EEELRKQREEIT 848
+ EE L +EE T
Sbjct: 1341 EEGAEEPLTTVQEEST 1356
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 91.7 bits (226), Expect = 4e-18
Identities = 53/186 (28%), Positives = 101/186 (54%), Gaps = 9/186 (4%)
Query: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVD 719
+S +P V +C++ + + GL +GIYR G + Q+L + Q+ + ++L + + + +
Sbjct: 291 NSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEK-LNLDDSQWEDIH 349
Query: 720 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL 779
V+ ALK F R+LP+ LF + ++EA + +D ++ + L+ +LPP NR T+K L
Sbjct: 350 VVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVL 409
Query: 780 ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD-------YKAGRVVEDLINHYVVV 832
HL + + N M+ +L IVFGPTL + + + ++ E +++ Y +
Sbjct: 410 FGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKI 469
Query: 833 FSVDEE 838
F +E+
Sbjct: 470 FGSEED 475
>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
Length = 1136
Score = 90.9 bits (224), Expect = 6e-18
Identities = 75/236 (31%), Positives = 105/236 (44%), Gaps = 42/236 (17%)
Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
+P IV +CV I + L ++GIYR G ++ ++L ++ V L + H D+S+
Sbjct: 774 VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPH--DISN 831
Query: 724 ALKRFLRDLPDGL--FTRAQRLTWLEASEIEDEEEK--------------------VSRY 761
LK +LR LP+ L F L L ++ E E R
Sbjct: 832 VLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRL 891
Query: 762 RELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ----------T 811
RELL LPP NRA+++ L+ HL + N+M NL IVFGPTL + +
Sbjct: 892 RELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLS 951
Query: 812 DGQDY-KAGRVVEDLINHYVVVFSVDEEEL-------RKQREEITAIVKMRVAGTA 859
DY RV+E LI HY +VF + EE QR E+ V AG A
Sbjct: 952 SLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEA 1007
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 90.9 bits (224), Expect = 6e-18
Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 1/162 (0%)
Query: 651 GDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH 710
G L + + IP+ V +CV++I GL +EG+YR G + + + QD +++
Sbjct: 1261 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1319
Query: 711 LKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPP 770
L E V+ V+ ALK F DLPD L + LEA++I D+ E++ +E++ + P
Sbjct: 1320 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1379
Query: 771 VNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812
VN + +I+HL V N M NL+I F PTL + D
Sbjct: 1380 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1421
>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
Length = 1501
Score = 90.9 bits (224), Expect = 6e-18
Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 1/162 (0%)
Query: 651 GDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH 710
G L + + IP+ V +CV++I GL +EG+YR G + + + QD +++
Sbjct: 1260 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1318
Query: 711 LKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPP 770
L E V+ V+ ALK F DLPD L + LEA++I D+ E++ +E++ + P
Sbjct: 1319 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1378
Query: 771 VNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812
VN + +I+HL V N M NL+I F PTL + D
Sbjct: 1379 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1420
>gi|56119110 family with sequence similarity 13, member A1 isoform a
[Homo sapiens]
Length = 1023
Score = 90.5 bits (223), Expect = 8e-18
Identities = 60/192 (31%), Positives = 96/192 (50%), Gaps = 8/192 (4%)
Query: 654 LSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE 713
L Q L ++ IP +V+ V+Y+TQ GLT EG++R G ++L K+
Sbjct: 48 LERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKD 107
Query: 714 GEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNR 773
G+ V +S LK FLR+LPD L T A + +++ + + + S R+L+ LP +
Sbjct: 108 GD--VCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHY 165
Query: 774 ATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQT----DGQDYK--AGRVVEDLIN 827
+K L L V N+MNVHNLA VFGP F +G + +++ ++
Sbjct: 166 CLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILE 225
Query: 828 HYVVVFSVDEEE 839
+Y +F V+ E
Sbjct: 226 NYNTLFEVEYTE 237
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 88.2 bits (217), Expect = 4e-17
Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 16/230 (6%)
Query: 620 VERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVI----VYRCVDYI 675
V+R + +Q D W+ A+ Q G + + I + +C+ +
Sbjct: 341 VDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAV 400
Query: 676 TQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE----GEQHVDDVSSALKRFLRD 731
G+ +G+YR G S+ Q+LL S+ D ++ E E + ++SALK +LR
Sbjct: 401 ETRGINEQGLYRIVGVNSRVQKLL-SVLMDPKTASETETDICAEWEIKTITSALKTYLRM 459
Query: 732 LPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSD 791
LP L + ++++A+++E++E +VS L+ RLP NR ++ L++HL V
Sbjct: 460 LPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHK 519
Query: 792 TNQMNVHNLAIVFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVFS 834
N M V NL +VFGPTL + + A V+E LI ++ +F+
Sbjct: 520 QNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFN 569
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 88.2 bits (217), Expect = 4e-17
Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 16/230 (6%)
Query: 620 VERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVI----VYRCVDYI 675
V+R + +Q D W+ A+ Q G + + I + +C+ +
Sbjct: 341 VDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAV 400
Query: 676 TQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE----GEQHVDDVSSALKRFLRD 731
G+ +G+YR G S+ Q+LL S+ D ++ E E + ++SALK +LR
Sbjct: 401 ETRGINEQGLYRIVGVNSRVQKLL-SVLMDPKTASETETDICAEWEIKTITSALKTYLRM 459
Query: 732 LPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSD 791
LP L + ++++A+++E++E +VS L+ RLP NR ++ L++HL V
Sbjct: 460 LPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHK 519
Query: 792 TNQMNVHNLAIVFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVFS 834
N M V NL +VFGPTL + + A V+E LI ++ +F+
Sbjct: 520 QNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFN 569
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 86.7 bits (213), Expect = 1e-16
Identities = 53/156 (33%), Positives = 79/156 (50%)
Query: 662 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721
S +P IV +CV+ I + G+ GIYR G + Q L + + + V + E V+ +
Sbjct: 1021 SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAI 1080
Query: 722 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781
+ LK + R+LP+ LFT + E + D K S LL+ LP N T L+
Sbjct: 1081 AGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLD 1140
Query: 782 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYK 817
HL V N+M++HNLA VFGPTL + ++ K
Sbjct: 1141 HLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESK 1176
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 86.7 bits (213), Expect = 1e-16
Identities = 53/156 (33%), Positives = 79/156 (50%)
Query: 662 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721
S +P IV +CV+ I + G+ GIYR G + Q L + + + V + E V+ +
Sbjct: 1065 SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAI 1124
Query: 722 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781
+ LK + R+LP+ LFT + E + D K S LL+ LP N T L+
Sbjct: 1125 AGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLD 1184
Query: 782 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYK 817
HL V N+M++HNLA VFGPTL + ++ K
Sbjct: 1185 HLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESK 1220
>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
[Homo sapiens]
Length = 1075
Score = 86.3 bits (212), Expect = 2e-16
Identities = 53/181 (29%), Positives = 92/181 (50%), Gaps = 6/181 (3%)
Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
IP++V C+ YI GL +GI+R G + + S + + + E+ ++ V+
Sbjct: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554
Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
LK + R L + LF + + + ++E+ E+V + +++LV LP V ++ L + L
Sbjct: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614
Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQD-----YKAGRVVEDLINHYVVVFSVDE 837
+ +SD N M+ +NLAI FGPTL DGQD V++ +I H+ +F
Sbjct: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPR 674
Query: 838 E 838
E
Sbjct: 675 E 675
>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
[Homo sapiens]
Length = 1099
Score = 86.3 bits (212), Expect = 2e-16
Identities = 53/181 (29%), Positives = 92/181 (50%), Gaps = 6/181 (3%)
Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
IP++V C+ YI GL +GI+R G + + S + + + E+ ++ V+
Sbjct: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 578
Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
LK + R L + LF + + + ++E+ E+V + +++LV LP V ++ L + L
Sbjct: 579 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 638
Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQD-----YKAGRVVEDLINHYVVVFSVDE 837
+ +SD N M+ +NLAI FGPTL DGQD V++ +I H+ +F
Sbjct: 639 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPR 698
Query: 838 E 838
E
Sbjct: 699 E 699
>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
sapiens]
Length = 748
Score = 85.5 bits (210), Expect = 3e-16
Identities = 65/238 (27%), Positives = 114/238 (47%), Gaps = 19/238 (7%)
Query: 591 EGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKA---- 646
E PC E + L E+ GD + + + + + D W+ +I++
Sbjct: 72 EHPCNEENPGKFLFEVVPGGDRDR----MTANHESYLLMASTQNDMEDWVKSIRRVIWGP 127
Query: 647 ------AASMGDTLS-EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLL 699
+ DT+ E++ G+ P++V +CVD+I Q GL EG++R GQ + + L
Sbjct: 128 FGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQ 187
Query: 700 ESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEI--EDEEEK 757
++ D + V V+S LK +LR+LP+ + A+ +L +++ ++EE
Sbjct: 188 DAF--DCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG 245
Query: 758 VSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815
V + + LP VN +K + L VQ +S N+M+V NLA VFGP + + +D
Sbjct: 246 VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVED 303
Score = 30.8 bits (68), Expect = 7.6
Identities = 27/110 (24%), Positives = 39/110 (35%), Gaps = 8/110 (7%)
Query: 466 RWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGER----- 520
RW VL L YF++E P G I P + + + FEV G+R
Sbjct: 39 RWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTA 98
Query: 521 ---LYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAG 567
YL + +WVK I + P + + E R + G
Sbjct: 99 NHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYG 148
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 85.5 bits (210), Expect = 3e-16
Identities = 62/218 (28%), Positives = 106/218 (48%), Gaps = 16/218 (7%)
Query: 631 ERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIP----VIVYRCVDYITQCGLTSEGIY 686
E R ++ LG + + S + + G++ + I+ +C+ + G+ +G+Y
Sbjct: 358 EERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLY 417
Query: 687 RKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD----DVSSALKRFLRDLPDGLFTRAQR 742
R G +SK QRLL S+ D ++ + + E D ++SALK++LR LP+ L T
Sbjct: 418 RVVGVSSKVQRLL-SMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELH 476
Query: 743 LTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAI 802
++ ++ E +V+ L+ +LP N+ + L+ HL V S N M V NL +
Sbjct: 477 GDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGV 536
Query: 803 VFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVF 833
VFGPTL + + A VVE LI ++ +F
Sbjct: 537 VFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIF 574
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 84.7 bits (208), Expect = 4e-16
Identities = 56/178 (31%), Positives = 90/178 (50%), Gaps = 9/178 (5%)
Query: 665 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVSS 723
P++V C+ I GL SEG+YR G + + + + +D + + ++ ++
Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341
Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
ALK + RDLP L T ++E+++I D +E++ E L LPP + T++ L++HL
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 401
Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAG--------RVVEDLINHYVVVF 833
V N MN NL IVFGPTL ++ D A VVE LI + ++F
Sbjct: 402 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 459
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 84.7 bits (208), Expect = 4e-16
Identities = 56/178 (31%), Positives = 90/178 (50%), Gaps = 9/178 (5%)
Query: 665 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVSS 723
P++V C+ I GL SEG+YR G + + + + +D + + ++ ++
Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315
Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
ALK + RDLP L T ++E+++I D +E++ E L LPP + T++ L++HL
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375
Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAG--------RVVEDLINHYVVVF 833
V N MN NL IVFGPTL ++ D A VVE LI + ++F
Sbjct: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433
>gi|5803145 ralA binding protein 1 [Homo sapiens]
Length = 655
Score = 84.0 bits (206), Expect = 8e-16
Identities = 54/168 (32%), Positives = 88/168 (52%), Gaps = 3/168 (1%)
Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
+P + C+DY+ + G+ EGIYR G SK L + ++ S +L++ E + V+S
Sbjct: 209 LPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDRE-ESTNLEDYEPNT--VAS 265
Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
LK++LRDLP+ L T+ + EA E EKV ++ LL LP N + LI H+
Sbjct: 266 LLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHM 325
Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVV 831
V +MN+ N++IV PT+ ++ Y V++L + V+
Sbjct: 326 DHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVL 373
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,257,853
Number of Sequences: 37866
Number of extensions: 2149529
Number of successful extensions: 7206
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 6583
Number of HSP's gapped (non-prelim): 539
length of query: 1133
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1020
effective length of database: 13,968,660
effective search space: 14248033200
effective search space used: 14248033200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.