BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 isoform d [Homo sapiens] (1133 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 2285 0.0 gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 1572 0.0 gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 1572 0.0 gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 724 0.0 gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 422 e-118 gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 100 1e-20 gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 99 2e-20 gi|194272142 myosin IXB isoform 2 [Homo sapiens] 97 7e-20 gi|33356170 myosin IXB isoform 1 [Homo sapiens] 97 7e-20 gi|156119615 myosin IXA [Homo sapiens] 97 9e-20 gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 96 2e-19 gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 96 2e-19 gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] 95 4e-19 gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 92 2e-18 gi|188497642 ARHGAP15 [Homo sapiens] 92 4e-18 gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] 91 6e-18 gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 91 6e-18 gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi... 91 6e-18 gi|56119110 family with sequence similarity 13, member A1 isofor... 91 8e-18 gi|208022687 GTPase regulator associated with the focal adhesion... 88 4e-17 gi|7662208 GTPase regulator associated with the focal adhesion k... 88 4e-17 gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 87 1e-16 gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 87 1e-16 gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ... 86 2e-16 gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ... 86 2e-16 gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa... 86 3e-16 gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 86 3e-16 gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 85 4e-16 gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 85 4e-16 gi|5803145 ralA binding protein 1 [Homo sapiens] 84 8e-16 >gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 isoform d [Homo sapiens] Length = 1133 Score = 2285 bits (5921), Expect = 0.0 Identities = 1133/1133 (100%), Positives = 1133/1133 (100%) Query: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL Sbjct: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60 Query: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD Sbjct: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120 Query: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA Sbjct: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180 Query: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM Sbjct: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240 Query: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA Sbjct: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300 Query: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL 360 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL Sbjct: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL 360 Query: 361 CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR 420 CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR Sbjct: 361 CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR 420 Query: 421 LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN 480 LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN Sbjct: 421 LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN 480 Query: 481 ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA 540 ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA Sbjct: 481 ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA 540 Query: 541 KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL 600 KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL Sbjct: 541 KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL 600 Query: 601 RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG 660 RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG Sbjct: 601 RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG 660 Query: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD Sbjct: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720 Query: 721 VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780 VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI Sbjct: 721 VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780 Query: 781 SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840 SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL Sbjct: 781 SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840 Query: 841 RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI 900 RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI Sbjct: 841 RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI 900 Query: 901 LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML 960 LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML Sbjct: 901 LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML 960 Query: 961 LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW 1020 LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW Sbjct: 961 LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW 1020 Query: 1021 PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD 1080 PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD Sbjct: 1021 PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD 1080 Query: 1081 GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV 1133 GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV Sbjct: 1081 GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV 1133 >gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 isoform a [Homo sapiens] Length = 1205 Score = 1572 bits (4071), Expect = 0.0 Identities = 819/1022 (80%), Positives = 863/1022 (84%), Gaps = 78/1022 (7%) Query: 132 ISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVP 191 + +V + + F++ T R F+F A+S++E+++W++A+Q A+AE + + ++ P Sbjct: 242 VGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAP 301 Query: 192 -------GSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGN 244 G+ QPD A + V + K H G+G V Sbjct: 302 NRFCADCGAPQPDWAS---------------INLCVVICKRCAGEHRGLGA-----GVSK 341 Query: 245 VKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAA--APN 302 V+ + +++++ W E + + + R WAA P+ Sbjct: 342 VRSL--------------------KMDRKVWTETLIELFLQL--GNGAGNRFWAANVPPS 379 Query: 303 RFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEALCA 362 +P S C + K G++R + L ++ E L +ALCA Sbjct: 380 EALQPSSSP-----STRRCHLEAKYREGKYR-------RYHPLFGNQ----EELDKALCA 423 Query: 363 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 422 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD Sbjct: 424 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 483 Query: 423 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 482 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER Sbjct: 484 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 543 Query: 483 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 542 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA Sbjct: 544 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 603 Query: 543 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 602 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK Sbjct: 604 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 663 Query: 603 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 662 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS Sbjct: 664 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 723 Query: 663 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 722 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS Sbjct: 724 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 783 Query: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH Sbjct: 784 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 843 Query: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 842 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK Sbjct: 844 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 903 Query: 843 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 902 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD Sbjct: 904 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 963 Query: 903 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 962 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY Sbjct: 964 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 1023 Query: 963 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR---------- 1012 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR Sbjct: 1024 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPE 1083 Query: 1013 -SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1071 SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF Sbjct: 1084 TSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1143 Query: 1072 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1131 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR Sbjct: 1144 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1203 Query: 1132 NV 1133 NV Sbjct: 1204 NV 1205 Score = 728 bits (1880), Expect = 0.0 Identities = 358/358 (100%), Positives = 358/358 (100%) Query: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL Sbjct: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60 Query: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD Sbjct: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120 Query: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA Sbjct: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180 Query: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM Sbjct: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240 Query: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA Sbjct: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300 Query: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE Sbjct: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358 >gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 isoform c [Homo sapiens] Length = 1450 Score = 1572 bits (4071), Expect = 0.0 Identities = 819/1022 (80%), Positives = 863/1022 (84%), Gaps = 78/1022 (7%) Query: 132 ISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVP 191 + +V + + F++ T R F+F A+S++E+++W++A+Q A+AE + + ++ P Sbjct: 487 VGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAP 546 Query: 192 -------GSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGN 244 G+ QPD A + V + K H G+G V Sbjct: 547 NRFCADCGAPQPDWAS---------------INLCVVICKRCAGEHRGLGA-----GVSK 586 Query: 245 VKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAA--APN 302 V+ + +++++ W E + + + R WAA P+ Sbjct: 587 VRSL--------------------KMDRKVWTETLIELFLQL--GNGAGNRFWAANVPPS 624 Query: 303 RFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEALCA 362 +P S C + K G++R + L ++ E L +ALCA Sbjct: 625 EALQPSSSP-----STRRCHLEAKYREGKYR-------RYHPLFGNQ----EELDKALCA 668 Query: 363 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 422 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD Sbjct: 669 AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 728 Query: 423 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 482 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER Sbjct: 729 SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 788 Query: 483 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 542 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA Sbjct: 789 AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 848 Query: 543 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 602 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK Sbjct: 849 FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 908 Query: 603 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 662 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS Sbjct: 909 LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 968 Query: 663 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 722 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS Sbjct: 969 DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 1028 Query: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH Sbjct: 1029 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 1088 Query: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 842 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK Sbjct: 1089 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 1148 Query: 843 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 902 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD Sbjct: 1149 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 1208 Query: 903 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 962 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY Sbjct: 1209 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 1268 Query: 963 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR---------- 1012 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR Sbjct: 1269 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPE 1328 Query: 1013 -SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1071 SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF Sbjct: 1329 TSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1388 Query: 1072 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1131 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR Sbjct: 1389 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1448 Query: 1132 NV 1133 NV Sbjct: 1449 NV 1450 Score = 728 bits (1880), Expect = 0.0 Identities = 358/358 (100%), Positives = 358/358 (100%) Query: 1 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL Sbjct: 246 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 305 Query: 61 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD Sbjct: 306 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 365 Query: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA Sbjct: 366 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 425 Query: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM Sbjct: 426 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 485 Query: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA Sbjct: 486 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 545 Query: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE Sbjct: 546 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 603 >gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 [Homo sapiens] Length = 1704 Score = 724 bits (1869), Expect = 0.0 Identities = 427/1131 (37%), Positives = 633/1131 (55%), Gaps = 117/1131 (10%) Query: 84 IKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKF 143 +K+GWLDK PQG ++QKRWV+ D + Y+++ K+ YSK I ++ IS V GD KF Sbjct: 484 VKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKF 543 Query: 144 EVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLE 203 EV+T RTF FR E + ER +W+ L A+ Q ++ + P++ G LE Sbjct: 544 EVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVT--------PEKCGYLE 595 Query: 204 LRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDR---RSFDLTTPYR 260 LRG+K K++ + G+ V L KN +++ G+GIT I M+V NVK+VDR +SF++ TPYR Sbjct: 596 LRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYR 655 Query: 261 IFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPD------ 314 FSF+A++E EK+ W+EA+Q +IAE LS EVAE+IW NR CADC AP PD Sbjct: 656 SFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINL 715 Query: 315 -------------------------------WAS--INLCVVICKRCAGEHRGLGAGVSK 341 W++ I L +VI + A + + K Sbjct: 716 CVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDF--WAGNLQK 773 Query: 342 VRSLKMDRKV------------------------WTETLIEALCAAVTTTDLAETQALLG 377 L MD V E L +ALCAAV D+ ET ALL Sbjct: 774 DEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLF 833 Query: 378 CGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPT 437 GA + C +GDP TP LA++AGQ+LQMEFL +N+ ++ P+ D H VL Sbjct: 834 SGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDI------HSEGVLSQ 887 Query: 438 VSHSG-----FLYKTASAG-KLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIR 491 S FLY+ SA KL +++ EE +++WCVL G LSY+EN+++ TPNG I Sbjct: 888 ESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTIN 947 Query: 492 ASEIVCLAVPPPDTH---GFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLA 548 +E++CLA+ D + G FE+Y ER++LFG E+++ +W + IAK FVP A Sbjct: 948 INEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFA 1007 Query: 549 EDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE-EPLQLRKLQELS 607 E+L D++ +G+L YK +L + ++GWF++ S L + + + LR+LQEL+ Sbjct: 1008 ENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELT 1067 Query: 608 I----QGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSD 663 I Q + VL+LVE+ RTLYI G +LDF W AI+KAA + G+ L +QQL +D Sbjct: 1068 ISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKND 1127 Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723 +P+IV C+ ++TQ GL + IY+K G LLES ++DARS L+ G+ ++DV++ Sbjct: 1128 VPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTA 1187 Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783 LK FL D+ D L T+ W+ A + +D++E++ +Y + LP VNRAT+ A+I HL Sbjct: 1188 VLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHL 1247 Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQ 843 Y VQ S+ N MN HNLA+VF LFQT GQ + V+EDLIN+YV +F V E+++++ Sbjct: 1248 YRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQM 1307 Query: 844 REEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDR 903 E + I K + + AGD + VY+E K+ + I++ M AEELT +IL Sbjct: 1308 DIENSFITKWK----DTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAI 1363 Query: 904 RNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGT-----DSHLVVKKHQAMEA 958 +N+ + D W FEV E EE ERPLH+ E VL + + ++LVVK+ + Sbjct: 1364 KNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADT 1423 Query: 959 ML-LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPE 1017 + S +G K G++K +E+ S + L F DRYF+L L LYK+V+S + + Sbjct: 1424 IKHCSDRSTLGSIKEGILKIKEEPSKI---LSGNKFQDRYFVLRDGFLFLYKDVKSSKHD 1480 Query: 1018 KEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFV 1077 K + + S+K Y GVKKK++PPT WG T EK W+LCCD+ EW + Sbjct: 1481 KMFSLSSMKFYRGVKKKMKPPTSWGLTAY-----SEKHHWHLCCDSSRTQTEWMTSIFIA 1535 Query: 1078 QHDGLVWPSEPSRVSRAVPE-VRLGSVSLIPLR--GSENEMRRSVAAFTAD 1125 QH+ +WP R++ + ++G + LIP++ G+ R+++ + A+ Sbjct: 1536 QHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAE 1586 >gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 [Homo sapiens] Length = 1544 Score = 422 bits (1086), Expect = e-118 Identities = 278/785 (35%), Positives = 406/785 (51%), Gaps = 68/785 (8%) Query: 356 LIEALCAAVTTTDLAETQALLGCGAGINCFSGD----PEAPTPLALAEQAGQTLQMEFLR 411 L++ALCAAV +L + L C + F G+ P AP Sbjct: 616 LLQALCAAVARPNLLKNMTQLLC---VEAFEGEEPWFPPAPDG----------------- 655 Query: 412 NNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKL--LQDRRAREEFSRRWCV 469 P L P Y+ V+ ++SGFLY + + K RR R+ R WCV Sbjct: 656 -----SCPGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCV 710 Query: 470 LGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHG---FEHTFEVYTEGERLYLFGL 526 LG L F +E + P I+ +IVCL V PP T F +FE+ G R+ FG Sbjct: 711 LG-AALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGT 769 Query: 527 ESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFS----LSG 582 + A+ W + K F P LL RLGRL ++ A W S L G Sbjct: 770 DGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRG 829 Query: 583 SELRAVFPEGPC----EEPLQLRKLQELSIQGDSEN----QVLVLVERRRTLYIQGERRL 634 L GP E+ + LR+LQE+S+ ++ + LVLVE RTLY+QGE RL Sbjct: 830 DHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRL 889 Query: 635 DFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSK 694 DF W AI AA G L EQQ+ DIP+IV C+ ++TQ GL EG+YRK G ++ Sbjct: 890 DFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARAR 949 Query: 695 TQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDE 754 + RLL R+DARSV L+ GE V+DV+ LKRF R+L D + + W EA+E+ + Sbjct: 950 SLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQK 1009 Query: 755 EEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQ 814 +++ +Y++++ LP VNR T+ LI HLY VQ + NQM NLA++F P++FQTDG+ Sbjct: 1010 NQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGR 1069 Query: 815 DYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYL 874 RV+++LI+ Y+ VF +D +++ + E++ I + + AGD I VY+ Sbjct: 1070 GEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLS----QAGDLIMEVYI 1125 Query: 875 EEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEK 934 E++ + +KV ++TAEELT ++L+ R D W FE+ E E ERPLH EK Sbjct: 1126 EQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTA-AGMDLWVTFEIREHGELERPLHPKEK 1184 Query: 935 VLP-----ILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFRED-RSLLGLGL 988 VL + L++KK +A L+ R + G+++ RE+ LLG Sbjct: 1185 VLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLG--- 1241 Query: 989 PSGGFHDRYFILNSSCLRLYKEVRSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHE 1048 F +R+F+L CL L KE +S +PE+EWP++ KVYLG++KKL+PPT WGFT++ Sbjct: 1242 --SRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLI-- 1297 Query: 1049 TEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPL 1108 EK YL C + E+ +W + L QHD S + + G++ L+P+ Sbjct: 1298 ---LEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPI 1354 Query: 1109 RGSEN 1113 RG ++ Sbjct: 1355 RGDDS 1359 Score = 261 bits (666), Expect = 3e-69 Identities = 131/282 (46%), Positives = 185/282 (65%), Gaps = 13/282 (4%) Query: 80 VTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIG 139 +TP++ +GWLDK PQG+Y++Q+R+V+ + L YF S+KD + K I + I + Sbjct: 286 LTPLL-SGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSK 344 Query: 140 DQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDR- 198 D KF+VIT R F FR ES+ +R W LQ + EQR LLG P QP R Sbjct: 345 DNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQR---------LLGHPRPPQPPRP 395 Query: 199 --AGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLT 256 G LELRG K K++ A+ ++ LYK+ + + LGIGI FI++ +V+E RSFDL Sbjct: 396 LRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLL 455 Query: 257 TPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWA 316 TP+R FSF+A+S ++ W A+Q A+ E LS EVAE+IW+ NR CADCG+ +PDWA Sbjct: 456 TPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWA 515 Query: 317 SINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358 ++NL VVICK+CAG+HR LG+G+SKV+SLK+D VW+ +++ Sbjct: 516 AVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQ 557 >gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] Length = 1397 Score = 99.8 bits (247), Expect = 1e-20 Identities = 64/185 (34%), Positives = 98/185 (52%), Gaps = 9/185 (4%) Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVS 722 +P+IV C + GL S GIYR G + L E L + ++L++ Q ++ +S Sbjct: 825 VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVIS 884 Query: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782 S LK F R LP+ LFT + ++EA+ IED E++ R+L+ LP T+K L+ H Sbjct: 885 SLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGH 944 Query: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDY--------KAGRVVEDLINHYVVVFS 834 L + S+ N+M NLA+VFGPTL +T + ++VE LI H FS Sbjct: 945 LKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFS 1004 Query: 835 VDEEE 839 +E++ Sbjct: 1005 DEEDK 1009 >gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo sapiens] Length = 1499 Score = 99.0 bits (245), Expect = 2e-20 Identities = 55/152 (36%), Positives = 84/152 (55%), Gaps = 1/152 (0%) Query: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720 + IP+ + RC++YI GL++EGIYR G S+ + L QD ++ L E + V+ Sbjct: 1258 EKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQD-HNLDLAEKDFTVNT 1316 Query: 721 VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780 V+ A+K F +LPD L ++ +EA +I D E+K+ +E+L + P N K +I Sbjct: 1317 VAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVI 1376 Query: 781 SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812 SHL V + N M NL+I F PTL + D Sbjct: 1377 SHLNKVSHNNKVNLMTSENLSICFWPTLMRPD 1408 >gi|194272142 myosin IXB isoform 2 [Homo sapiens] Length = 2022 Score = 97.4 bits (241), Expect = 7e-20 Identities = 57/196 (29%), Positives = 112/196 (57%), Gaps = 5/196 (2%) Query: 662 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721 + +P+++ + ++++ GL +EG+YRK G ++T+ L ++L+ D +V L+ H + Sbjct: 1710 ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--I 1767 Query: 722 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781 + LK++LR+LP+ L T AQ +L A E+ +++E+++ +L LP N +++ LI Sbjct: 1768 TGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIF 1827 Query: 782 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840 HL V D N+M+ LAI+F P L + D D ++D++ V + +E++ Sbjct: 1828 HLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQM 1885 Query: 841 RKQREEITAIVKMRVA 856 RK + ++ I ++ A Sbjct: 1886 RKYKVKMEEISQLEAA 1901 >gi|33356170 myosin IXB isoform 1 [Homo sapiens] Length = 2157 Score = 97.4 bits (241), Expect = 7e-20 Identities = 57/196 (29%), Positives = 112/196 (57%), Gaps = 5/196 (2%) Query: 662 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721 + +P+++ + ++++ GL +EG+YRK G ++T+ L ++L+ D +V L+ H + Sbjct: 1710 ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--I 1767 Query: 722 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781 + LK++LR+LP+ L T AQ +L A E+ +++E+++ +L LP N +++ LI Sbjct: 1768 TGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIF 1827 Query: 782 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840 HL V D N+M+ LAI+F P L + D D ++D++ V + +E++ Sbjct: 1828 HLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQM 1885 Query: 841 RKQREEITAIVKMRVA 856 RK + ++ I ++ A Sbjct: 1886 RKYKVKMEEISQLEAA 1901 >gi|156119615 myosin IXA [Homo sapiens] Length = 2548 Score = 97.1 bits (240), Expect = 9e-20 Identities = 66/219 (30%), Positives = 114/219 (52%), Gaps = 5/219 (2%) Query: 646 AAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQD 705 ++ G LS D +P++V + ++YI GL +EGIYRK G T+K + L + L D Sbjct: 2057 SSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTD 2116 Query: 706 ARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELL 765 A SV+L + HV ++S K++LRDLP+ L T +L A +++ +E + ++ Sbjct: 2117 AESVNLDDYNIHV--IASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVI 2174 Query: 766 VRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVED 824 +L + T++ LI HL + DTN+M+ + LAIVF P + + D D + V+D Sbjct: 2175 DQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTD--PLQSVQD 2232 Query: 825 LINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQ 863 + V + E++ K + + I + A + T+ Sbjct: 2233 ISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTR 2271 >gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sapiens] Length = 521 Score = 95.9 bits (237), Expect = 2e-19 Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 57/401 (14%) Query: 437 TVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEI- 495 T+ +G L++T +A K R ++ +S W VL GVL++F++ + G + S+ Sbjct: 128 TLDKAGVLHRTKTADK--GKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFS 185 Query: 496 ----------VCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAK---- 541 L+ P D ++ E+ + YL +S W K IA+ Sbjct: 186 TPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQE 245 Query: 542 --AFVPPLAEDLLARDF---ERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPE-GPCE 595 A +PP + DF ERLG S Q +E + A P GP Sbjct: 246 LSAELPPEESESSRVDFGSSERLG--------SWQEKEED------ARPNAAAPALGPVG 291 Query: 596 EPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLS 655 L K++ +++ ++RR TL E+ G A L Sbjct: 292 LESDLSKVR---------HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA-------LC 335 Query: 656 EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE 715 E++ S +P V +C+ + GL +G+YR G + Q+L + D R + L +G Sbjct: 336 ERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGR 392 Query: 716 -QHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 774 + V ++ ALK F R+LP+ LF + ++ A +++D+ + R+L+ LP N Sbjct: 393 WEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHD 452 Query: 775 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815 T++ L HL V + N+M+V ++AIVFGPTL + + ++ Sbjct: 453 TLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE 493 >gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sapiens] Length = 548 Score = 95.9 bits (237), Expect = 2e-19 Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 57/401 (14%) Query: 437 TVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEI- 495 T+ +G L++T +A K R ++ +S W VL GVL++F++ + G + S+ Sbjct: 155 TLDKAGVLHRTKTADK--GKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFS 212 Query: 496 ----------VCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAK---- 541 L+ P D ++ E+ + YL +S W K IA+ Sbjct: 213 TPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQE 272 Query: 542 --AFVPPLAEDLLARDF---ERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPE-GPCE 595 A +PP + DF ERLG S Q +E + A P GP Sbjct: 273 LSAELPPEESESSRVDFGSSERLG--------SWQEKEED------ARPNAAAPALGPVG 318 Query: 596 EPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLS 655 L K++ +++ ++RR TL E+ G A L Sbjct: 319 LESDLSKVR---------HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA-------LC 362 Query: 656 EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE 715 E++ S +P V +C+ + GL +G+YR G + Q+L + D R + L +G Sbjct: 363 ERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGR 419 Query: 716 -QHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 774 + V ++ ALK F R+LP+ LF + ++ A +++D+ + R+L+ LP N Sbjct: 420 WEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHD 479 Query: 775 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815 T++ L HL V + N+M+V ++AIVFGPTL + + ++ Sbjct: 480 TLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE 520 >gi|34013590 Rho GTPase activating protein 2 [Homo sapiens] Length = 698 Score = 94.7 bits (234), Expect = 4e-19 Identities = 86/304 (28%), Positives = 142/304 (46%), Gaps = 27/304 (8%) Query: 575 EGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRL 634 +G+ SL G+++ + P GP E+P + L E+S G E + + L +R Sbjct: 78 QGFISLQGTQVTEL-PPGP-EDPG--KHLFEISPGGAGEREKVPANPEALLLMASSQR-- 131 Query: 635 DFMGWLGAIQKAA-ASMGDTLSEQQL----------GDSDIPVIVYRCVDYITQCGLTSE 683 D W+ AI++ A +G + Q+L G P++V +CVD+I + GLT E Sbjct: 132 DMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEE 191 Query: 684 GIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRL 743 G++R GQ + + L +S D L + V V+S LK +LR+LP+ + A+ Sbjct: 192 GLFRMPGQANLVRDLQDSF--DCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYE 249 Query: 744 TWLEASEI--EDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLA 801 +L +++ +DE E + + LP N ++ + L VQ +S+ N+M+V NLA Sbjct: 250 DFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLA 309 Query: 802 IVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASG 861 VFGP + + +D L+ H + V +RK + TA V G Sbjct: 310 TVFGPNILRPQVEDPVTIMEGTSLVQHLMTVL------IRKHSQLFTAPVPEGPTSPRGG 363 Query: 862 TQHA 865 Q A Sbjct: 364 LQCA 367 Score = 38.9 bits (89), Expect = 0.028 Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 10/118 (8%) Query: 450 AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFE 509 AG L + R + + +RW VL L Y++++ + P G I +PP + Sbjct: 41 AGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGK 100 Query: 510 HTFEVYT--EGER--------LYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFE 557 H FE+ GER L S +WV+ I + PL + + E Sbjct: 101 HLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQRLE 158 Score = 35.0 bits (79), Expect = 0.40 Identities = 29/111 (26%), Positives = 49/111 (44%), Gaps = 22/111 (19%) Query: 82 PVIKAGWLDKNPPQGSYI--YQKRWVRLDTDHLRYFDSNKDAYSKRFISVACI------- 132 PV+KAGWL K Q S + +Q+RW L D L Y+ + + FIS+ Sbjct: 37 PVLKAGWLKK---QRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPP 93 Query: 133 ------SHVAAI----GDQKFEVITNNRTFAFRAESDVERKEWMQALQQAM 173 H+ I ++ +V N A S + ++W+QA+++ + Sbjct: 94 GPEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144 >gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] Length = 1958 Score = 92.4 bits (228), Expect = 2e-18 Identities = 64/196 (32%), Positives = 102/196 (52%), Gaps = 11/196 (5%) Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVS 722 IP+IV C + + GL GIYR G + + E L + + +++ + + ++ +S Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220 Query: 723 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782 S LK F R LP+ LFT + ++EA+ ED +++ + L+ LP + T+K L +H Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280 Query: 783 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDY--------KAGRVVEDLINHYVVVFS 834 L V S+ N+M NLAIVFGPTL +T + ++VE LI H+ F+ Sbjct: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFT 1340 Query: 835 VD--EEELRKQREEIT 848 + EE L +EE T Sbjct: 1341 EEGAEEPLTTVQEEST 1356 >gi|188497642 ARHGAP15 [Homo sapiens] Length = 475 Score = 91.7 bits (226), Expect = 4e-18 Identities = 53/186 (28%), Positives = 101/186 (54%), Gaps = 9/186 (4%) Query: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVD 719 +S +P V +C++ + + GL +GIYR G + Q+L + Q+ + ++L + + + + Sbjct: 291 NSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEK-LNLDDSQWEDIH 349 Query: 720 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL 779 V+ ALK F R+LP+ LF + ++EA + +D ++ + L+ +LPP NR T+K L Sbjct: 350 VVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVL 409 Query: 780 ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD-------YKAGRVVEDLINHYVVV 832 HL + + N M+ +L IVFGPTL + + + ++ E +++ Y + Sbjct: 410 FGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKI 469 Query: 833 FSVDEE 838 F +E+ Sbjct: 470 FGSEED 475 >gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens] Length = 1136 Score = 90.9 bits (224), Expect = 6e-18 Identities = 75/236 (31%), Positives = 105/236 (44%), Gaps = 42/236 (17%) Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723 +P IV +CV I + L ++GIYR G ++ ++L ++ V L + H D+S+ Sbjct: 774 VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPH--DISN 831 Query: 724 ALKRFLRDLPDGL--FTRAQRLTWLEASEIEDEEEK--------------------VSRY 761 LK +LR LP+ L F L L ++ E E R Sbjct: 832 VLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRL 891 Query: 762 RELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ----------T 811 RELL LPP NRA+++ L+ HL + N+M NL IVFGPTL + + Sbjct: 892 RELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLS 951 Query: 812 DGQDY-KAGRVVEDLINHYVVVFSVDEEEL-------RKQREEITAIVKMRVAGTA 859 DY RV+E LI HY +VF + EE QR E+ V AG A Sbjct: 952 SLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEA 1007 >gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens] Length = 1502 Score = 90.9 bits (224), Expect = 6e-18 Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 1/162 (0%) Query: 651 GDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH 710 G L + + IP+ V +CV++I GL +EG+YR G + + + QD +++ Sbjct: 1261 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1319 Query: 711 LKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPP 770 L E V+ V+ ALK F DLPD L + LEA++I D+ E++ +E++ + P Sbjct: 1320 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1379 Query: 771 VNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812 VN + +I+HL V N M NL+I F PTL + D Sbjct: 1380 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1421 >gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens] Length = 1501 Score = 90.9 bits (224), Expect = 6e-18 Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 1/162 (0%) Query: 651 GDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH 710 G L + + IP+ V +CV++I GL +EG+YR G + + + QD +++ Sbjct: 1260 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1318 Query: 711 LKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPP 770 L E V+ V+ ALK F DLPD L + LEA++I D+ E++ +E++ + P Sbjct: 1319 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1378 Query: 771 VNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812 VN + +I+HL V N M NL+I F PTL + D Sbjct: 1379 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1420 >gi|56119110 family with sequence similarity 13, member A1 isoform a [Homo sapiens] Length = 1023 Score = 90.5 bits (223), Expect = 8e-18 Identities = 60/192 (31%), Positives = 96/192 (50%), Gaps = 8/192 (4%) Query: 654 LSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE 713 L Q L ++ IP +V+ V+Y+TQ GLT EG++R G ++L K+ Sbjct: 48 LERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKD 107 Query: 714 GEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNR 773 G+ V +S LK FLR+LPD L T A + +++ + + + S R+L+ LP + Sbjct: 108 GD--VCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHY 165 Query: 774 ATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQT----DGQDYK--AGRVVEDLIN 827 +K L L V N+MNVHNLA VFGP F +G + +++ ++ Sbjct: 166 CLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILE 225 Query: 828 HYVVVFSVDEEE 839 +Y +F V+ E Sbjct: 226 NYNTLFEVEYTE 237 >gi|208022687 GTPase regulator associated with the focal adhesion kinase pp125 isoform b [Homo sapiens] Length = 759 Score = 88.2 bits (217), Expect = 4e-17 Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 16/230 (6%) Query: 620 VERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVI----VYRCVDYI 675 V+R + +Q D W+ A+ Q G + + I + +C+ + Sbjct: 341 VDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAV 400 Query: 676 TQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE----GEQHVDDVSSALKRFLRD 731 G+ +G+YR G S+ Q+LL S+ D ++ E E + ++SALK +LR Sbjct: 401 ETRGINEQGLYRIVGVNSRVQKLL-SVLMDPKTASETETDICAEWEIKTITSALKTYLRM 459 Query: 732 LPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSD 791 LP L + ++++A+++E++E +VS L+ RLP NR ++ L++HL V Sbjct: 460 LPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHK 519 Query: 792 TNQMNVHNLAIVFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVFS 834 N M V NL +VFGPTL + + A V+E LI ++ +F+ Sbjct: 520 QNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFN 569 >gi|7662208 GTPase regulator associated with the focal adhesion kinase pp125 isoform a [Homo sapiens] Length = 814 Score = 88.2 bits (217), Expect = 4e-17 Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 16/230 (6%) Query: 620 VERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVI----VYRCVDYI 675 V+R + +Q D W+ A+ Q G + + I + +C+ + Sbjct: 341 VDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAV 400 Query: 676 TQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE----GEQHVDDVSSALKRFLRD 731 G+ +G+YR G S+ Q+LL S+ D ++ E E + ++SALK +LR Sbjct: 401 ETRGINEQGLYRIVGVNSRVQKLL-SVLMDPKTASETETDICAEWEIKTITSALKTYLRM 459 Query: 732 LPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSD 791 LP L + ++++A+++E++E +VS L+ RLP NR ++ L++HL V Sbjct: 460 LPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHK 519 Query: 792 TNQMNVHNLAIVFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVFS 834 N M V NL +VFGPTL + + A V+E LI ++ +F+ Sbjct: 520 QNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFN 569 >gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] Length = 1227 Score = 86.7 bits (213), Expect = 1e-16 Identities = 53/156 (33%), Positives = 79/156 (50%) Query: 662 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721 S +P IV +CV+ I + G+ GIYR G + Q L + + + V + E V+ + Sbjct: 1021 SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAI 1080 Query: 722 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781 + LK + R+LP+ LFT + E + D K S LL+ LP N T L+ Sbjct: 1081 AGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLD 1140 Query: 782 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYK 817 HL V N+M++HNLA VFGPTL + ++ K Sbjct: 1141 HLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESK 1176 >gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] Length = 1271 Score = 86.7 bits (213), Expect = 1e-16 Identities = 53/156 (33%), Positives = 79/156 (50%) Query: 662 SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721 S +P IV +CV+ I + G+ GIYR G + Q L + + + V + E V+ + Sbjct: 1065 SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAI 1124 Query: 722 SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781 + LK + R+LP+ LFT + E + D K S LL+ LP N T L+ Sbjct: 1125 AGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLD 1184 Query: 782 HLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYK 817 HL V N+M++HNLA VFGPTL + ++ K Sbjct: 1185 HLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESK 1220 >gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b [Homo sapiens] Length = 1075 Score = 86.3 bits (212), Expect = 2e-16 Identities = 53/181 (29%), Positives = 92/181 (50%), Gaps = 6/181 (3%) Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723 IP++V C+ YI GL +GI+R G + + S + + + E+ ++ V+ Sbjct: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554 Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783 LK + R L + LF + + + ++E+ E+V + +++LV LP V ++ L + L Sbjct: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614 Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQD-----YKAGRVVEDLINHYVVVFSVDE 837 + +SD N M+ +NLAI FGPTL DGQD V++ +I H+ +F Sbjct: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPR 674 Query: 838 E 838 E Sbjct: 675 E 675 >gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a [Homo sapiens] Length = 1099 Score = 86.3 bits (212), Expect = 2e-16 Identities = 53/181 (29%), Positives = 92/181 (50%), Gaps = 6/181 (3%) Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723 IP++V C+ YI GL +GI+R G + + S + + + E+ ++ V+ Sbjct: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 578 Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783 LK + R L + LF + + + ++E+ E+V + +++LV LP V ++ L + L Sbjct: 579 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 638 Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQD-----YKAGRVVEDLINHYVVVFSVDE 837 + +SD N M+ +NLAI FGPTL DGQD V++ +I H+ +F Sbjct: 639 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPR 698 Query: 838 E 838 E Sbjct: 699 E 699 >gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sapiens] Length = 748 Score = 85.5 bits (210), Expect = 3e-16 Identities = 65/238 (27%), Positives = 114/238 (47%), Gaps = 19/238 (7%) Query: 591 EGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKA---- 646 E PC E + L E+ GD + + + + + D W+ +I++ Sbjct: 72 EHPCNEENPGKFLFEVVPGGDRDR----MTANHESYLLMASTQNDMEDWVKSIRRVIWGP 127 Query: 647 ------AASMGDTLS-EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLL 699 + DT+ E++ G+ P++V +CVD+I Q GL EG++R GQ + + L Sbjct: 128 FGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQ 187 Query: 700 ESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEI--EDEEEK 757 ++ D + V V+S LK +LR+LP+ + A+ +L +++ ++EE Sbjct: 188 DAF--DCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG 245 Query: 758 VSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815 V + + LP VN +K + L VQ +S N+M+V NLA VFGP + + +D Sbjct: 246 VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVED 303 Score = 30.8 bits (68), Expect = 7.6 Identities = 27/110 (24%), Positives = 39/110 (35%), Gaps = 8/110 (7%) Query: 466 RWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGER----- 520 RW VL L YF++E P G I P + + + FEV G+R Sbjct: 39 RWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTA 98 Query: 521 ---LYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAG 567 YL + +WVK I + P + + E R + G Sbjct: 99 NHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYG 148 >gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] Length = 786 Score = 85.5 bits (210), Expect = 3e-16 Identities = 62/218 (28%), Positives = 106/218 (48%), Gaps = 16/218 (7%) Query: 631 ERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIP----VIVYRCVDYITQCGLTSEGIY 686 E R ++ LG + + S + + G++ + I+ +C+ + G+ +G+Y Sbjct: 358 EERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLY 417 Query: 687 RKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD----DVSSALKRFLRDLPDGLFTRAQR 742 R G +SK QRLL S+ D ++ + + E D ++SALK++LR LP+ L T Sbjct: 418 RVVGVSSKVQRLL-SMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELH 476 Query: 743 LTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAI 802 ++ ++ E +V+ L+ +LP N+ + L+ HL V S N M V NL + Sbjct: 477 GDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGV 536 Query: 803 VFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVF 833 VFGPTL + + A VVE LI ++ +F Sbjct: 537 VFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIF 574 >gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] Length = 459 Score = 84.7 bits (208), Expect = 4e-16 Identities = 56/178 (31%), Positives = 90/178 (50%), Gaps = 9/178 (5%) Query: 665 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVSS 723 P++V C+ I GL SEG+YR G + + + + +D + + ++ ++ Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341 Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783 ALK + RDLP L T ++E+++I D +E++ E L LPP + T++ L++HL Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 401 Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAG--------RVVEDLINHYVVVF 833 V N MN NL IVFGPTL ++ D A VVE LI + ++F Sbjct: 402 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 459 >gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] Length = 433 Score = 84.7 bits (208), Expect = 4e-16 Identities = 56/178 (31%), Positives = 90/178 (50%), Gaps = 9/178 (5%) Query: 665 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVSS 723 P++V C+ I GL SEG+YR G + + + + +D + + ++ ++ Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315 Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783 ALK + RDLP L T ++E+++I D +E++ E L LPP + T++ L++HL Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375 Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAG--------RVVEDLINHYVVVF 833 V N MN NL IVFGPTL ++ D A VVE LI + ++F Sbjct: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433 >gi|5803145 ralA binding protein 1 [Homo sapiens] Length = 655 Score = 84.0 bits (206), Expect = 8e-16 Identities = 54/168 (32%), Positives = 88/168 (52%), Gaps = 3/168 (1%) Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723 +P + C+DY+ + G+ EGIYR G SK L + ++ S +L++ E + V+S Sbjct: 209 LPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDRE-ESTNLEDYEPNT--VAS 265 Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783 LK++LRDLP+ L T+ + EA E EKV ++ LL LP N + LI H+ Sbjct: 266 LLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHM 325 Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVV 831 V +MN+ N++IV PT+ ++ Y V++L + V+ Sbjct: 326 DHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVL 373 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.318 0.134 0.403 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 45,257,853 Number of Sequences: 37866 Number of extensions: 2149529 Number of successful extensions: 7206 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 164 Number of HSP's successfully gapped in prelim test: 85 Number of HSP's that attempted gapping in prelim test: 6583 Number of HSP's gapped (non-prelim): 539 length of query: 1133 length of database: 18,247,518 effective HSP length: 113 effective length of query: 1020 effective length of database: 13,968,660 effective search space: 14248033200 effective search space used: 14248033200 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.