Guide to the Human Genome
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Search of human proteins with 206597515

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform d [Homo sapiens]
         (1133 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH do...  2285   0.0  
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do...  1572   0.0  
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...  1572   0.0  
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...   724   0.0  
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom...   422   e-118
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]          100   1e-20
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ...    99   2e-20
gi|194272142 myosin IXB isoform 2 [Homo sapiens]                       97   7e-20
gi|33356170 myosin IXB isoform 1 [Homo sapiens]                        97   7e-20
gi|156119615 myosin IXA [Homo sapiens]                                 97   9e-20
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa...    96   2e-19
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap...    96   2e-19
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]             95   4e-19
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]           92   2e-18
gi|188497642 ARHGAP15 [Homo sapiens]                                   92   4e-18
gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]       91   6e-18
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi...    91   6e-18
gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapi...    91   6e-18
gi|56119110 family with sequence similarity 13, member A1 isofor...    91   8e-18
gi|208022687 GTPase regulator associated with the focal adhesion...    88   4e-17
gi|7662208 GTPase regulator associated with the focal adhesion k...    88   4e-17
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]         87   1e-16
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]         87   1e-16
gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b ...    86   2e-16
gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a ...    86   2e-16
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    86   3e-16
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]            86   3e-16
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]             85   4e-16
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]           85   4e-16
gi|5803145 ralA binding protein 1 [Homo sapiens]                       84   8e-16

>gi|206597515 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
            1 isoform d [Homo sapiens]
          Length = 1133

 Score = 2285 bits (5921), Expect = 0.0
 Identities = 1133/1133 (100%), Positives = 1133/1133 (100%)

Query: 1    MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
            MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
Sbjct: 1    MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60

Query: 61   PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
            PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
Sbjct: 61   PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120

Query: 121  AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
            AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
Sbjct: 121  AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180

Query: 181  RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
            RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
Sbjct: 181  RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240

Query: 241  SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
            SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
Sbjct: 241  SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300

Query: 301  PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL 360
            PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL
Sbjct: 301  PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEAL 360

Query: 361  CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR 420
            CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR
Sbjct: 361  CAAVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPR 420

Query: 421  LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN 480
            LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN
Sbjct: 421  LDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFEN 480

Query: 481  ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA 540
            ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA
Sbjct: 481  ERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIA 540

Query: 541  KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL 600
            KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL
Sbjct: 541  KAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQL 600

Query: 601  RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG 660
            RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG
Sbjct: 601  RKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLG 660

Query: 661  DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720
            DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD
Sbjct: 661  DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720

Query: 721  VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780
            VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI
Sbjct: 721  VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780

Query: 781  SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840
            SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL
Sbjct: 781  SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840

Query: 841  RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI 900
            RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI
Sbjct: 841  RKQREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEI 900

Query: 901  LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML 960
            LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML
Sbjct: 901  LDRRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAML 960

Query: 961  LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW 1020
            LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW
Sbjct: 961  LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPEKEW 1020

Query: 1021 PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD 1080
            PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD
Sbjct: 1021 PIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFVQHD 1080

Query: 1081 GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV 1133
            GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV
Sbjct: 1081 GLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLRNV 1133


>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
            1 isoform a [Homo sapiens]
          Length = 1205

 Score = 1572 bits (4071), Expect = 0.0
 Identities = 819/1022 (80%), Positives = 863/1022 (84%), Gaps = 78/1022 (7%)

Query: 132  ISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVP 191
            + +V  +  + F++ T  R F+F A+S++E+++W++A+Q A+AE  + + ++       P
Sbjct: 242  VGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAP 301

Query: 192  -------GSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGN 244
                   G+ QPD A                +   V + K     H G+G       V  
Sbjct: 302  NRFCADCGAPQPDWAS---------------INLCVVICKRCAGEHRGLGA-----GVSK 341

Query: 245  VKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAA--APN 302
            V+ +                    +++++ W E +     +    +    R WAA   P+
Sbjct: 342  VRSL--------------------KMDRKVWTETLIELFLQL--GNGAGNRFWAANVPPS 379

Query: 303  RFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEALCA 362
                   +P     S   C +  K   G++R       +   L  ++    E L +ALCA
Sbjct: 380  EALQPSSSP-----STRRCHLEAKYREGKYR-------RYHPLFGNQ----EELDKALCA 423

Query: 363  AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 422
            AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD
Sbjct: 424  AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 483

Query: 423  SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 482
            SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER
Sbjct: 484  SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 543

Query: 483  AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 542
            AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA
Sbjct: 544  AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 603

Query: 543  FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 602
            FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK
Sbjct: 604  FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 663

Query: 603  LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 662
            LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS
Sbjct: 664  LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 723

Query: 663  DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 722
            DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS
Sbjct: 724  DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 783

Query: 723  SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
            SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH
Sbjct: 784  SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 843

Query: 783  LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 842
            LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK
Sbjct: 844  LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 903

Query: 843  QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 902
            QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD
Sbjct: 904  QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 963

Query: 903  RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 962
            RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY
Sbjct: 964  RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 1023

Query: 963  LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR---------- 1012
            LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR          
Sbjct: 1024 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPE 1083

Query: 1013 -SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1071
             SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF
Sbjct: 1084 TSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1143

Query: 1072 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1131
            ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR
Sbjct: 1144 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1203

Query: 1132 NV 1133
            NV
Sbjct: 1204 NV 1205



 Score =  728 bits (1880), Expect = 0.0
 Identities = 358/358 (100%), Positives = 358/358 (100%)

Query: 1   MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
           MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
Sbjct: 1   MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60

Query: 61  PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
           PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
Sbjct: 61  PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120

Query: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
           AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
Sbjct: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180

Query: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
           RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
Sbjct: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240

Query: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
           SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
Sbjct: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300

Query: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
           PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE
Sbjct: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358


>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
            isoform c [Homo sapiens]
          Length = 1450

 Score = 1572 bits (4071), Expect = 0.0
 Identities = 819/1022 (80%), Positives = 863/1022 (84%), Gaps = 78/1022 (7%)

Query: 132  ISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVP 191
            + +V  +  + F++ T  R F+F A+S++E+++W++A+Q A+AE  + + ++       P
Sbjct: 487  VGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAP 546

Query: 192  -------GSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGN 244
                   G+ QPD A                +   V + K     H G+G       V  
Sbjct: 547  NRFCADCGAPQPDWAS---------------INLCVVICKRCAGEHRGLGA-----GVSK 586

Query: 245  VKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAA--APN 302
            V+ +                    +++++ W E +     +    +    R WAA   P+
Sbjct: 587  VRSL--------------------KMDRKVWTETLIELFLQL--GNGAGNRFWAANVPPS 624

Query: 303  RFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIEALCA 362
                   +P     S   C +  K   G++R       +   L  ++    E L +ALCA
Sbjct: 625  EALQPSSSP-----STRRCHLEAKYREGKYR-------RYHPLFGNQ----EELDKALCA 668

Query: 363  AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 422
            AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD
Sbjct: 669  AVTTTDLAETQALLGCGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLD 728

Query: 423  SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 482
            SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER
Sbjct: 729  SMKPLEKHYSVVLPTVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENER 788

Query: 483  AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 542
            AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA
Sbjct: 789  AVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKA 848

Query: 543  FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 602
            FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK
Sbjct: 849  FVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCEEPLQLRK 908

Query: 603  LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 662
            LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS
Sbjct: 909  LQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDS 968

Query: 663  DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 722
            DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS
Sbjct: 969  DIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVS 1028

Query: 723  SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
            SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH
Sbjct: 1029 SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 1088

Query: 783  LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 842
            LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK
Sbjct: 1089 LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRK 1148

Query: 843  QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 902
            QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD
Sbjct: 1149 QREEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILD 1208

Query: 903  RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 962
            RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY
Sbjct: 1209 RRNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGTDSHLVVKKHQAMEAMLLY 1268

Query: 963  LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR---------- 1012
            LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVR          
Sbjct: 1269 LASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPE 1328

Query: 1013 -SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1071
             SHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF
Sbjct: 1329 TSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWF 1388

Query: 1072 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1131
            ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR
Sbjct: 1389 ATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPLRGSENEMRRSVAAFTADPLSLLR 1448

Query: 1132 NV 1133
            NV
Sbjct: 1449 NV 1450



 Score =  728 bits (1880), Expect = 0.0
 Identities = 358/358 (100%), Positives = 358/358 (100%)

Query: 1   MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 60
           MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL
Sbjct: 246 MTKKEEPPPSRVPRAVRVASLLSEGEELSGDDQGDEEEDDHAYEGVPNGGWHTSSLSLSL 305

Query: 61  PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 120
           PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD
Sbjct: 306 PSTIAAPHPMDGPPGGSTPVTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKD 365

Query: 121 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 180
           AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA
Sbjct: 366 AYSKRFISVACISHVAAIGDQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARA 425

Query: 181 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 240
           RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM
Sbjct: 426 RLSSAYLLGVPGSEQPDRAGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDM 485

Query: 241 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 300
           SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA
Sbjct: 486 SVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAA 545

Query: 301 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
           PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE
Sbjct: 546 PNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 603


>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
            [Homo sapiens]
          Length = 1704

 Score =  724 bits (1869), Expect = 0.0
 Identities = 427/1131 (37%), Positives = 633/1131 (55%), Gaps = 117/1131 (10%)

Query: 84   IKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIGDQKF 143
            +K+GWLDK  PQG  ++QKRWV+ D   + Y+++ K+ YSK  I ++ IS V   GD KF
Sbjct: 484  VKSGWLDKLSPQGKRMFQKRWVKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNKF 543

Query: 144  EVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDRAGSLE 203
            EV+T  RTF FR E + ER +W+  L  A+  Q   ++  +           P++ G LE
Sbjct: 544  EVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTSQSQAVVT--------PEKCGYLE 595

Query: 204  LRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDR---RSFDLTTPYR 260
            LRG+K K++  + G+ V L KN +++  G+GIT I M+V NVK+VDR   +SF++ TPYR
Sbjct: 596  LRGYKAKIFTVLSGNSVWLCKNEQDFKSGLGITIIPMNVANVKQVDRTVKQSFEIITPYR 655

Query: 261  IFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPD------ 314
             FSF+A++E EK+ W+EA+Q +IAE LS  EVAE+IW    NR CADC AP PD      
Sbjct: 656  SFSFTAETEKEKQDWIEAVQQSIAETLSDYEVAEKIWFNESNRSCADCKAPDPDWASINL 715

Query: 315  -------------------------------WAS--INLCVVICKRCAGEHRGLGAGVSK 341
                                           W++  I L +VI  + A +       + K
Sbjct: 716  CVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRANDF--WAGNLQK 773

Query: 342  VRSLKMDRKV------------------------WTETLIEALCAAVTTTDLAETQALLG 377
               L MD  V                          E L +ALCAAV   D+ ET ALL 
Sbjct: 774  DEELHMDSPVEKRKNFITQKYKEGKFRKTLLASLTKEELNKALCAAVVKPDVLETMALLF 833

Query: 378  CGAGINCFSGDPEAPTPLALAEQAGQTLQMEFLRNNRTTEVPRLDSMKPLEKHYSVVLPT 437
             GA + C +GDP   TP  LA++AGQ+LQMEFL +N+ ++ P+ D       H   VL  
Sbjct: 834  SGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNKFSDFPQHDI------HSEGVLSQ 887

Query: 438  VSHSG-----FLYKTASAG-KLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIR 491
             S        FLY+  SA  KL  +++  EE +++WCVL  G LSY+EN+++ TPNG I 
Sbjct: 888  ESSQSTFLCDFLYQAPSAASKLSSEKKLLEETNKKWCVLEGGFLSYYENDKSTTPNGTIN 947

Query: 492  ASEIVCLAVPPPDTH---GFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLA 548
             +E++CLA+   D +   G    FE+Y   ER++LFG E+++   +W + IAK FVP  A
Sbjct: 948  INEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGAETSQAQRKWTEAIAKHFVPLFA 1007

Query: 549  EDLLARDFERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPEGPCE-EPLQLRKLQELS 607
            E+L   D++ +G+L YK   +L + ++GWF++  S L         + + + LR+LQEL+
Sbjct: 1008 ENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFCLQMQEVQGDRMHLRRLQELT 1067

Query: 608  I----QGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSD 663
            I    Q   +  VL+LVE+ RTLYI G  +LDF  W  AI+KAA + G+ L +QQL  +D
Sbjct: 1068 ISTMVQNGEKLDVLLLVEKGRTLYIHGHTKLDFTVWHTAIEKAAGTDGNALQDQQLSKND 1127

Query: 664  IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
            +P+IV  C+ ++TQ GL  + IY+K G       LLES ++DARS  L+ G+  ++DV++
Sbjct: 1128 VPIIVNSCIAFVTQYGLGCKYIYQKNGDPLHISELLESFKKDARSFKLRAGKHQLEDVTA 1187

Query: 724  ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
             LK FL D+ D L T+     W+ A + +D++E++ +Y   +  LP VNRAT+ A+I HL
Sbjct: 1188 VLKSFLSDIDDALLTKELYPYWISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHL 1247

Query: 784  YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQ 843
            Y VQ  S+ N MN HNLA+VF   LFQT GQ  +   V+EDLIN+YV +F V E+++++ 
Sbjct: 1248 YRVQKCSEINHMNAHNLALVFSSCLFQTKGQTSEEVNVIEDLINNYVEIFEVKEDQVKQM 1307

Query: 844  REEITAIVKMRVAGTASGTQHAGDFICTVYLEEKKAETEQHIKVPASMTAEELTLEILDR 903
              E + I K +     +    AGD +  VY+E K+ +    I++   M AEELT +IL  
Sbjct: 1308 DIENSFITKWK----DTQVSQAGDLLIEVYVERKEPDCSIIIRISPVMEAEELTNDILAI 1363

Query: 904  RNVGIREKDYWTCFEVNEREEAERPLHFAEKVLPILHGLGT-----DSHLVVKKHQAMEA 958
            +N+   + D W  FEV E EE ERPLH+ E VL  +    +      ++LVVK+    + 
Sbjct: 1364 KNIIPTKGDIWATFEVIENEELERPLHYKENVLEQVLRWSSLAEPGSAYLVVKRFLTADT 1423

Query: 959  ML-LYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSHRPE 1017
            +      S +G  K G++K +E+ S +   L    F DRYF+L    L LYK+V+S + +
Sbjct: 1424 IKHCSDRSTLGSIKEGILKIKEEPSKI---LSGNKFQDRYFVLRDGFLFLYKDVKSSKHD 1480

Query: 1018 KEWPIKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLFV 1077
            K + + S+K Y GVKKK++PPT WG T        EK  W+LCCD+     EW  +    
Sbjct: 1481 KMFSLSSMKFYRGVKKKMKPPTSWGLTAY-----SEKHHWHLCCDSSRTQTEWMTSIFIA 1535

Query: 1078 QHDGLVWPSEPSRVSRAVPE-VRLGSVSLIPLR--GSENEMRRSVAAFTAD 1125
            QH+  +WP       R++ +  ++G + LIP++  G+    R+++ +  A+
Sbjct: 1536 QHEYDIWPPAGKERKRSITKNPKIGGLPLIPIQHEGNATLARKNIESARAE 1586


>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
            [Homo sapiens]
          Length = 1544

 Score =  422 bits (1086), Expect = e-118
 Identities = 278/785 (35%), Positives = 406/785 (51%), Gaps = 68/785 (8%)

Query: 356  LIEALCAAVTTTDLAETQALLGCGAGINCFSGD----PEAPTPLALAEQAGQTLQMEFLR 411
            L++ALCAAV   +L +    L C   +  F G+    P AP                   
Sbjct: 616  LLQALCAAVARPNLLKNMTQLLC---VEAFEGEEPWFPPAPDG----------------- 655

Query: 412  NNRTTEVPRLDSMKPLEKHYSVVLPTVSHSGFLYKTASAGKL--LQDRRAREEFSRRWCV 469
                   P L    P    Y+ V+   ++SGFLY +  + K      RR R+   R WCV
Sbjct: 656  -----SCPGLLPSDPSPGVYNEVVVRATYSGFLYCSPVSNKAGPSPPRRGRDAPPRLWCV 710

Query: 470  LGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHG---FEHTFEVYTEGERLYLFGL 526
            LG   L  F +E +  P   I+  +IVCL V PP T     F  +FE+   G R+  FG 
Sbjct: 711  LG-AALEMFASENSPEPLSLIQPQDIVCLGVSPPPTDPGDRFPFSFELILAGGRIQHFGT 769

Query: 527  ESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWFS----LSG 582
            + A+    W   + K F P     LL     RLGRL  ++      A   W S    L G
Sbjct: 770  DGADSLEAWTSAVGKWFSPLSCHQLLGPGLLRLGRLWLRSPSHTAPAPGLWLSGFGLLRG 829

Query: 583  SELRAVFPEGPC----EEPLQLRKLQELSIQGDSEN----QVLVLVERRRTLYIQGERRL 634
              L      GP     E+ + LR+LQE+S+   ++     + LVLVE  RTLY+QGE RL
Sbjct: 830  DHLFLCSAPGPGPPAPEDMVHLRRLQEISVVSAADTPDKKEHLVLVETGRTLYLQGEGRL 889

Query: 635  DFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSK 694
            DF  W  AI  AA   G  L EQQ+   DIP+IV  C+ ++TQ GL  EG+YRK G  ++
Sbjct: 890  DFTAWNAAIGGAAGGGGTGLQEQQMSRGDIPIIVDACISFVTQHGLRLEGVYRKGGARAR 949

Query: 695  TQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDE 754
            + RLL   R+DARSV L+ GE  V+DV+  LKRF R+L D + +      W EA+E+  +
Sbjct: 950  SLRLLAEFRRDARSVKLRPGEHFVEDVTDTLKRFFRELDDPVTSARLLPRWREAAELPQK 1009

Query: 755  EEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQ 814
             +++ +Y++++  LP VNR T+  LI HLY VQ  +  NQM   NLA++F P++FQTDG+
Sbjct: 1010 NQRLEKYKDVIGCLPRVNRRTLATLIGHLYRVQKCAALNQMCTRNLALLFAPSVFQTDGR 1069

Query: 815  DYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQHAGDFICTVYL 874
                 RV+++LI+ Y+ VF +D +++ +   E++ I   +    +     AGD I  VY+
Sbjct: 1070 GEHEVRVLQELIDGYISVFDIDSDQVAQIDLEVSLITTWKDVQLS----QAGDLIMEVYI 1125

Query: 875  EEKKAETEQHIKVPASMTAEELTLEILDRRNVGIREKDYWTCFEVNEREEAERPLHFAEK 934
            E++  +    +KV  ++TAEELT ++L+ R       D W  FE+ E  E ERPLH  EK
Sbjct: 1126 EQQLPDNCVTLKVSPTLTAEELTNQVLEMRGTA-AGMDLWVTFEIREHGELERPLHPKEK 1184

Query: 935  VLP-----ILHGLGTDSHLVVKKHQAMEAMLLYLASRVGDTKHGMMKFRED-RSLLGLGL 988
            VL              + L++KK    +A  L+   R    + G+++ RE+   LLG   
Sbjct: 1185 VLEQALQWCQLPEPCSASLLLKKVPLAQAGCLFTGIRRESPRVGLLRCREEPPRLLG--- 1241

Query: 989  PSGGFHDRYFILNSSCLRLYKEVRSHRPEKEWPIKSLKVYLGVKKKLRPPTCWGFTVVHE 1048
                F +R+F+L   CL L KE +S +PE+EWP++  KVYLG++KKL+PPT WGFT++  
Sbjct: 1242 --SRFQERFFLLRGRCLLLLKEKKSSKPEREWPLEGAKVYLGIRKKLKPPTPWGFTLI-- 1297

Query: 1049 TEKHEKQQWYLCCDTQMELREWFATFLFVQHDGLVWPSEPSRVSRAVPEVRLGSVSLIPL 1108
                EK   YL C  + E+ +W  + L  QHD           S  +   + G++ L+P+
Sbjct: 1298 ---LEKMHLYLSCTDEDEMWDWTTSILKAQHDDQQPVVLRRHSSSDLARQKFGTMPLLPI 1354

Query: 1109 RGSEN 1113
            RG ++
Sbjct: 1355 RGDDS 1359



 Score =  261 bits (666), Expect = 3e-69
 Identities = 131/282 (46%), Positives = 185/282 (65%), Gaps = 13/282 (4%)

Query: 80  VTPVIKAGWLDKNPPQGSYIYQKRWVRLDTDHLRYFDSNKDAYSKRFISVACISHVAAIG 139
           +TP++ +GWLDK  PQG+Y++Q+R+V+ +   L YF S+KD + K  I +  I    +  
Sbjct: 286 LTPLL-SGWLDKLSPQGNYVFQRRFVQFNGRSLMYFGSDKDPFPKGVIPLTAIEMTRSSK 344

Query: 140 DQKFEVITNNRTFAFRAESDVERKEWMQALQQAMAEQRARARLSSAYLLGVPGSEQPDR- 198
           D KF+VIT  R F FR ES+ +R  W   LQ  + EQR         LLG P   QP R 
Sbjct: 345 DNKFQVITGQRVFVFRTESEAQRDMWCSTLQSCLKEQR---------LLGHPRPPQPPRP 395

Query: 199 --AGSLELRGFKNKLYVAVVGDKVQLYKNLEEYHLGIGITFIDMSVGNVKEVDRRSFDLT 256
              G LELRG K K++ A+   ++ LYK+ + + LGIGI FI++   +V+E   RSFDL 
Sbjct: 396 LRTGMLELRGHKAKVFAALSPGELALYKSEQAFSLGIGICFIELQGCSVRETKSRSFDLL 455

Query: 257 TPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAPQPDWA 316
           TP+R FSF+A+S   ++ W  A+Q A+ E LS  EVAE+IW+   NR CADCG+ +PDWA
Sbjct: 456 TPHRCFSFTAESGGARQSWAAALQEAVTETLSDYEVAEKIWSNRANRQCADCGSSRPDWA 515

Query: 317 SINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTETLIE 358
           ++NL VVICK+CAG+HR LG+G+SKV+SLK+D  VW+  +++
Sbjct: 516 AVNLGVVICKQCAGQHRALGSGISKVQSLKLDTSVWSNEIVQ 557


>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
          Length = 1397

 Score = 99.8 bits (247), Expect = 1e-20
 Identities = 64/185 (34%), Positives = 98/185 (52%), Gaps = 9/185 (4%)

Query: 664  IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVS 722
            +P+IV  C   +   GL S GIYR  G  +    L E L +    ++L++   Q ++ +S
Sbjct: 825  VPLIVAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVIS 884

Query: 723  SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
            S LK F R LP+ LFT  +   ++EA+ IED  E++   R+L+  LP     T+K L+ H
Sbjct: 885  SLLKSFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGH 944

Query: 783  LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDY--------KAGRVVEDLINHYVVVFS 834
            L  +   S+ N+M   NLA+VFGPTL +T   +            ++VE LI H    FS
Sbjct: 945  LKTIADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFS 1004

Query: 835  VDEEE 839
             +E++
Sbjct: 1005 DEEDK 1009


>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
            sapiens]
          Length = 1499

 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 55/152 (36%), Positives = 84/152 (55%), Gaps = 1/152 (0%)

Query: 661  DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDD 720
            +  IP+ + RC++YI   GL++EGIYR  G  S+ + L     QD  ++ L E +  V+ 
Sbjct: 1258 EKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQD-HNLDLAEKDFTVNT 1316

Query: 721  VSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALI 780
            V+ A+K F  +LPD L     ++  +EA +I D E+K+   +E+L + P  N    K +I
Sbjct: 1317 VAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVI 1376

Query: 781  SHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812
            SHL  V   +  N M   NL+I F PTL + D
Sbjct: 1377 SHLNKVSHNNKVNLMTSENLSICFWPTLMRPD 1408


>gi|194272142 myosin IXB isoform 2 [Homo sapiens]
          Length = 2022

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 57/196 (29%), Positives = 112/196 (57%), Gaps = 5/196 (2%)

Query: 662  SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721
            + +P+++ + ++++   GL +EG+YRK G  ++T+ L ++L+ D  +V L+    H   +
Sbjct: 1710 ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--I 1767

Query: 722  SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781
            +  LK++LR+LP+ L T AQ   +L A E+ +++E+++    +L  LP  N  +++ LI 
Sbjct: 1768 TGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIF 1827

Query: 782  HLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840
            HL  V    D N+M+   LAI+F P L +  D  D      ++D++     V  + +E++
Sbjct: 1828 HLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQM 1885

Query: 841  RKQREEITAIVKMRVA 856
            RK + ++  I ++  A
Sbjct: 1886 RKYKVKMEEISQLEAA 1901


>gi|33356170 myosin IXB isoform 1 [Homo sapiens]
          Length = 2157

 Score = 97.4 bits (241), Expect = 7e-20
 Identities = 57/196 (29%), Positives = 112/196 (57%), Gaps = 5/196 (2%)

Query: 662  SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721
            + +P+++ + ++++   GL +EG+YRK G  ++T+ L ++L+ D  +V L+    H   +
Sbjct: 1710 ASVPIVLEKLLEHVEMHGLYTEGLYRKSGAANRTRELRQALQTDPAAVKLENFPIHA--I 1767

Query: 722  SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781
            +  LK++LR+LP+ L T AQ   +L A E+ +++E+++    +L  LP  N  +++ LI 
Sbjct: 1768 TGVLKQWLRELPEPLMTFAQYGDFLRAVELPEKQEQLAAIYAVLEHLPEANHNSLERLIF 1827

Query: 782  HLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVEDLINHYVVVFSVDEEEL 840
            HL  V    D N+M+   LAI+F P L +  D  D      ++D++     V  + +E++
Sbjct: 1828 HLVKVALLEDVNRMSPGALAIIFAPCLLRCPDNSDPLTS--MKDVLKITTCVEMLIKEQM 1885

Query: 841  RKQREEITAIVKMRVA 856
            RK + ++  I ++  A
Sbjct: 1886 RKYKVKMEEISQLEAA 1901


>gi|156119615 myosin IXA [Homo sapiens]
          Length = 2548

 Score = 97.1 bits (240), Expect = 9e-20
 Identities = 66/219 (30%), Positives = 114/219 (52%), Gaps = 5/219 (2%)

Query: 646  AAASMGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQD 705
            ++   G  LS     D  +P++V + ++YI   GL +EGIYRK G T+K + L + L  D
Sbjct: 2057 SSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTD 2116

Query: 706  ARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELL 765
            A SV+L +   HV  ++S  K++LRDLP+ L T      +L A  +++ +E +     ++
Sbjct: 2117 AESVNLDDYNIHV--IASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVI 2174

Query: 766  VRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQDYKAGRVVED 824
             +L   +  T++ LI HL  +    DTN+M+ + LAIVF P + +  D  D    + V+D
Sbjct: 2175 DQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTD--PLQSVQD 2232

Query: 825  LINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASGTQ 863
            +      V  +  E++ K +  +  I  +  A   + T+
Sbjct: 2233 ISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTR 2271


>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
           sapiens]
          Length = 521

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 57/401 (14%)

Query: 437 TVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEI- 495
           T+  +G L++T +A K    R  ++ +S  W VL  GVL++F++ +     G  + S+  
Sbjct: 128 TLDKAGVLHRTKTADK--GKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFS 185

Query: 496 ----------VCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAK---- 541
                       L+  P D    ++  E+ +     YL   +S      W K IA+    
Sbjct: 186 TPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQE 245

Query: 542 --AFVPPLAEDLLARDF---ERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPE-GPCE 595
             A +PP   +    DF   ERLG        S Q  +E       +   A  P  GP  
Sbjct: 246 LSAELPPEESESSRVDFGSSERLG--------SWQEKEED------ARPNAAAPALGPVG 291

Query: 596 EPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLS 655
               L K++         +++   ++RR TL    E+        G    A       L 
Sbjct: 292 LESDLSKVR---------HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA-------LC 335

Query: 656 EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE 715
           E++   S +P  V +C+  +   GL  +G+YR  G  +  Q+L   +  D R + L +G 
Sbjct: 336 ERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGR 392

Query: 716 -QHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 774
            + V  ++ ALK F R+LP+ LF  +    ++ A +++D+  +    R+L+  LP  N  
Sbjct: 393 WEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHD 452

Query: 775 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815
           T++ L  HL  V    + N+M+V ++AIVFGPTL + + ++
Sbjct: 453 TLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE 493


>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
           sapiens]
          Length = 548

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 104/401 (25%), Positives = 177/401 (44%), Gaps = 57/401 (14%)

Query: 437 TVSHSGFLYKTASAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEI- 495
           T+  +G L++T +A K    R  ++ +S  W VL  GVL++F++ +     G  + S+  
Sbjct: 155 TLDKAGVLHRTKTADK--GKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFS 212

Query: 496 ----------VCLAVPPPDTHGFEHTFEVYTEGERLYLFGLESAEQAHEWVKCIAK---- 541
                       L+  P D    ++  E+ +     YL   +S      W K IA+    
Sbjct: 213 TPEYTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQE 272

Query: 542 --AFVPPLAEDLLARDF---ERLGRLPYKAGLSLQRAQEGWFSLSGSELRAVFPE-GPCE 595
             A +PP   +    DF   ERLG        S Q  +E       +   A  P  GP  
Sbjct: 273 LSAELPPEESESSRVDFGSSERLG--------SWQEKEED------ARPNAAAPALGPVG 318

Query: 596 EPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLS 655
               L K++         +++   ++RR TL    E+        G    A       L 
Sbjct: 319 LESDLSKVR---------HKLRKFLQRRPTLQSLREKGYIKDQVFGCALAA-------LC 362

Query: 656 EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE 715
           E++   S +P  V +C+  +   GL  +G+YR  G  +  Q+L   +  D R + L +G 
Sbjct: 363 ERER--SRVPRFVQQCIRAVEARGLDIDGLYRISGNLATIQKLRYKVDHDER-LDLDDGR 419

Query: 716 -QHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRA 774
            + V  ++ ALK F R+LP+ LF  +    ++ A +++D+  +    R+L+  LP  N  
Sbjct: 420 WEDVHVITGALKLFFRELPEPLFPFSHFRQFIAAIKLQDQARRSRCVRDLVRSLPAPNHD 479

Query: 775 TVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815
           T++ L  HL  V    + N+M+V ++AIVFGPTL + + ++
Sbjct: 480 TLRMLFQHLCRVIEHGEQNRMSVQSVAIVFGPTLLRPEVEE 520


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score = 94.7 bits (234), Expect = 4e-19
 Identities = 86/304 (28%), Positives = 142/304 (46%), Gaps = 27/304 (8%)

Query: 575 EGWFSLSGSELRAVFPEGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRL 634
           +G+ SL G+++  + P GP E+P   + L E+S  G  E + +        L    +R  
Sbjct: 78  QGFISLQGTQVTEL-PPGP-EDPG--KHLFEISPGGAGEREKVPANPEALLLMASSQR-- 131

Query: 635 DFMGWLGAIQKAA-ASMGDTLSEQQL----------GDSDIPVIVYRCVDYITQCGLTSE 683
           D   W+ AI++   A +G  +  Q+L          G    P++V +CVD+I + GLT E
Sbjct: 132 DMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEE 191

Query: 684 GIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRL 743
           G++R  GQ +  + L +S   D     L +    V  V+S LK +LR+LP+ +   A+  
Sbjct: 192 GLFRMPGQANLVRDLQDSF--DCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYE 249

Query: 744 TWLEASEI--EDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLA 801
            +L  +++  +DE E      + +  LP  N   ++ +   L  VQ +S+ N+M+V NLA
Sbjct: 250 DFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLA 309

Query: 802 IVFGPTLFQTDGQDYKAGRVVEDLINHYVVVFSVDEEELRKQREEITAIVKMRVAGTASG 861
            VFGP + +   +D         L+ H + V       +RK  +  TA V         G
Sbjct: 310 TVFGPNILRPQVEDPVTIMEGTSLVQHLMTVL------IRKHSQLFTAPVPEGPTSPRGG 363

Query: 862 TQHA 865
            Q A
Sbjct: 364 LQCA 367



 Score = 38.9 bits (89), Expect = 0.028
 Identities = 29/118 (24%), Positives = 46/118 (38%), Gaps = 10/118 (8%)

Query: 450 AGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFE 509
           AG L + R   + + +RW VL    L Y++++  + P G I         +PP      +
Sbjct: 41  AGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGK 100

Query: 510 HTFEVYT--EGER--------LYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFE 557
           H FE+     GER          L    S     +WV+ I +    PL   +  +  E
Sbjct: 101 HLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQRLE 158



 Score = 35.0 bits (79), Expect = 0.40
 Identities = 29/111 (26%), Positives = 49/111 (44%), Gaps = 22/111 (19%)

Query: 82  PVIKAGWLDKNPPQGSYI--YQKRWVRLDTDHLRYFDSNKDAYSKRFISVACI------- 132
           PV+KAGWL K   Q S +  +Q+RW  L  D L Y+    +   + FIS+          
Sbjct: 37  PVLKAGWLKK---QRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPP 93

Query: 133 ------SHVAAI----GDQKFEVITNNRTFAFRAESDVERKEWMQALQQAM 173
                  H+  I      ++ +V  N       A S  + ++W+QA+++ +
Sbjct: 94  GPEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVI 144


>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
          Length = 1958

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 64/196 (32%), Positives = 102/196 (52%), Gaps = 11/196 (5%)

Query: 664  IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVS 722
            IP+IV  C   + + GL   GIYR  G  +    + E L +    + +++ + + ++ +S
Sbjct: 1161 IPLIVDICCKLVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVIS 1220

Query: 723  SALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISH 782
            S LK F R LP+ LFT  +   ++EA+  ED  +++   + L+  LP  +  T+K L +H
Sbjct: 1221 SLLKSFFRKLPEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAH 1280

Query: 783  LYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDY--------KAGRVVEDLINHYVVVFS 834
            L  V   S+ N+M   NLAIVFGPTL +T   +            ++VE LI H+   F+
Sbjct: 1281 LKTVAENSEKNKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFT 1340

Query: 835  VD--EEELRKQREEIT 848
             +  EE L   +EE T
Sbjct: 1341 EEGAEEPLTTVQEEST 1356


>gi|188497642 ARHGAP15 [Homo sapiens]
          Length = 475

 Score = 91.7 bits (226), Expect = 4e-18
 Identities = 53/186 (28%), Positives = 101/186 (54%), Gaps = 9/186 (4%)

Query: 661 DSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVD 719
           +S +P  V +C++ + + GL  +GIYR  G  +  Q+L   + Q+ + ++L + + + + 
Sbjct: 291 NSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEK-LNLDDSQWEDIH 349

Query: 720 DVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKAL 779
            V+ ALK F R+LP+ LF  +    ++EA + +D   ++   + L+ +LPP NR T+K L
Sbjct: 350 VVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVL 409

Query: 780 ISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD-------YKAGRVVEDLINHYVVV 832
             HL  +   +  N M+  +L IVFGPTL + + +            ++ E +++ Y  +
Sbjct: 410 FGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKI 469

Query: 833 FSVDEE 838
           F  +E+
Sbjct: 470 FGSEED 475


>gi|47834348 minor histocompatibility antigen HA-1 [Homo sapiens]
          Length = 1136

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 75/236 (31%), Positives = 105/236 (44%), Gaps = 42/236 (17%)

Query: 664  IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
            +P IV +CV  I +  L ++GIYR  G  ++ ++L ++       V L +   H  D+S+
Sbjct: 774  VPFIVKKCVCEIERRALRTKGIYRVNGVKTRVEKLCQAFENGKELVELSQASPH--DISN 831

Query: 724  ALKRFLRDLPDGL--FTRAQRLTWLEASEIEDEEEK--------------------VSRY 761
             LK +LR LP+ L  F     L  L    ++ E E                       R 
Sbjct: 832  VLKLYLRQLPEPLISFRLYHELVGLAKDSLKAEAEAKAASRGRQDGSESEAVAVALAGRL 891

Query: 762  RELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQ----------T 811
            RELL  LPP NRA+++ L+ HL  +      N+M   NL IVFGPTL +          +
Sbjct: 892  RELLRDLPPENRASLQYLLRHLRRIVEVEQDNKMTPGNLGIVFGPTLLRPRPTEATVSLS 951

Query: 812  DGQDY-KAGRVVEDLINHYVVVFSVDEEEL-------RKQREEITAIVKMRVAGTA 859
               DY    RV+E LI HY +VF  + EE          QR E+   V    AG A
Sbjct: 952  SLVDYPHQARVIETLIVHYGLVFEEEPEETPGGQDESSNQRAEVVVQVPYLEAGEA 1007


>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
          Length = 1502

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 1/162 (0%)

Query: 651  GDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH 710
            G  L +    +  IP+ V +CV++I   GL +EG+YR  G  +    + +   QD  +++
Sbjct: 1261 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1319

Query: 711  LKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPP 770
            L   E  V+ V+ ALK F  DLPD L   +     LEA++I D+ E++   +E++ +  P
Sbjct: 1320 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1379

Query: 771  VNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812
            VN    + +I+HL  V      N M   NL+I F PTL + D
Sbjct: 1380 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1421


>gi|71834861 Rho GTPase activating protein 5 isoform b [Homo sapiens]
          Length = 1501

 Score = 90.9 bits (224), Expect = 6e-18
 Identities = 54/162 (33%), Positives = 85/162 (52%), Gaps = 1/162 (0%)

Query: 651  GDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVH 710
            G  L +    +  IP+ V +CV++I   GL +EG+YR  G  +    + +   QD  +++
Sbjct: 1260 GMPLQDLVTAEKPIPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQD-HNIN 1318

Query: 711  LKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPP 770
            L   E  V+ V+ ALK F  DLPD L   +     LEA++I D+ E++   +E++ +  P
Sbjct: 1319 LVSMEVTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKFHP 1378

Query: 771  VNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTD 812
            VN    + +I+HL  V      N M   NL+I F PTL + D
Sbjct: 1379 VNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPD 1420


>gi|56119110 family with sequence similarity 13, member A1 isoform a
           [Homo sapiens]
          Length = 1023

 Score = 90.5 bits (223), Expect = 8e-18
 Identities = 60/192 (31%), Positives = 96/192 (50%), Gaps = 8/192 (4%)

Query: 654 LSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE 713
           L  Q L ++ IP +V+  V+Y+TQ GLT EG++R  G     ++L             K+
Sbjct: 48  LERQGLTENGIPAVVWNIVEYLTQHGLTQEGLFRVNGNVKVVEQLRLKFESGVPVELGKD 107

Query: 714 GEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNR 773
           G+  V   +S LK FLR+LPD L T A +  +++  +    + + S  R+L+  LP  + 
Sbjct: 108 GD--VCSAASLLKLFLRELPDSLITSALQPRFIQLFQDGRNDVQESSLRDLIKELPDTHY 165

Query: 774 ATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQT----DGQDYK--AGRVVEDLIN 827
             +K L   L  V      N+MNVHNLA VFGP  F      +G   +    +++  ++ 
Sbjct: 166 CLLKYLCQFLTKVAKHHVQNRMNVHNLATVFGPNCFHVPPGLEGMKEQDLCNKIMAKILE 225

Query: 828 HYVVVFSVDEEE 839
           +Y  +F V+  E
Sbjct: 226 NYNTLFEVEYTE 237


>gi|208022687 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform b [Homo sapiens]
          Length = 759

 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 16/230 (6%)

Query: 620 VERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVI----VYRCVDYI 675
           V+R   + +Q     D   W+ A+             Q  G + +  I    + +C+  +
Sbjct: 341 VDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAV 400

Query: 676 TQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE----GEQHVDDVSSALKRFLRD 731
              G+  +G+YR  G  S+ Q+LL S+  D ++    E     E  +  ++SALK +LR 
Sbjct: 401 ETRGINEQGLYRIVGVNSRVQKLL-SVLMDPKTASETETDICAEWEIKTITSALKTYLRM 459

Query: 732 LPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSD 791
           LP  L     + ++++A+++E++E +VS    L+ RLP  NR  ++ L++HL  V     
Sbjct: 460 LPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHK 519

Query: 792 TNQMNVHNLAIVFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVFS 834
            N M V NL +VFGPTL +   +   A         V+E LI ++  +F+
Sbjct: 520 QNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFN 569


>gi|7662208 GTPase regulator associated with the focal adhesion
           kinase pp125 isoform a [Homo sapiens]
          Length = 814

 Score = 88.2 bits (217), Expect = 4e-17
 Identities = 64/230 (27%), Positives = 111/230 (48%), Gaps = 16/230 (6%)

Query: 620 VERRRTLYIQGERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIPVI----VYRCVDYI 675
           V+R   + +Q     D   W+ A+             Q  G + +  I    + +C+  +
Sbjct: 341 VDRPGVITMQALSEEDRRLWMEAMDGREPVYNSNKDSQSEGTAQLDSIGFSIIRKCIHAV 400

Query: 676 TQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKE----GEQHVDDVSSALKRFLRD 731
              G+  +G+YR  G  S+ Q+LL S+  D ++    E     E  +  ++SALK +LR 
Sbjct: 401 ETRGINEQGLYRIVGVNSRVQKLL-SVLMDPKTASETETDICAEWEIKTITSALKTYLRM 459

Query: 732 LPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSD 791
           LP  L     + ++++A+++E++E +VS    L+ RLP  NR  ++ L++HL  V     
Sbjct: 460 LPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHLANVANNHK 519

Query: 792 TNQMNVHNLAIVFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVFS 834
            N M V NL +VFGPTL +   +   A         V+E LI ++  +F+
Sbjct: 520 QNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFN 569


>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
          Length = 1227

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 53/156 (33%), Positives = 79/156 (50%)

Query: 662  SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721
            S +P IV +CV+ I + G+   GIYR  G  +  Q L  +   + + V +   E  V+ +
Sbjct: 1021 SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAI 1080

Query: 722  SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781
            +  LK + R+LP+ LFT      + E   + D   K S    LL+ LP  N  T   L+ 
Sbjct: 1081 AGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLD 1140

Query: 782  HLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYK 817
            HL  V      N+M++HNLA VFGPTL +   ++ K
Sbjct: 1141 HLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESK 1176


>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
          Length = 1271

 Score = 86.7 bits (213), Expect = 1e-16
 Identities = 53/156 (33%), Positives = 79/156 (50%)

Query: 662  SDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDV 721
            S +P IV +CV+ I + G+   GIYR  G  +  Q L  +   + + V +   E  V+ +
Sbjct: 1065 SKVPYIVRQCVEEIERRGMEEVGIYRVSGVATDIQALKAAFDVNNKDVSVMMSEMDVNAI 1124

Query: 722  SSALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALIS 781
            +  LK + R+LP+ LFT      + E   + D   K S    LL+ LP  N  T   L+ 
Sbjct: 1125 AGTLKLYFRELPEPLFTDEFYPNFAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLD 1184

Query: 782  HLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYK 817
            HL  V      N+M++HNLA VFGPTL +   ++ K
Sbjct: 1185 HLKRVAEKEAVNKMSLHNLATVFGPTLLRPSEKESK 1220


>gi|75677374 SLIT-ROBO Rho GTPase activating protein 3 isoform b
           [Homo sapiens]
          Length = 1075

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 53/181 (29%), Positives = 92/181 (50%), Gaps = 6/181 (3%)

Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
           IP++V  C+ YI   GL  +GI+R  G   +   +  S  +    +   + E+ ++ V+ 
Sbjct: 495 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 554

Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
            LK + R L + LF + +    +   ++E+  E+V + +++LV LP V    ++ L + L
Sbjct: 555 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 614

Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQD-----YKAGRVVEDLINHYVVVFSVDE 837
             +  +SD N M+ +NLAI FGPTL    DGQD          V++ +I H+  +F    
Sbjct: 615 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPR 674

Query: 838 E 838
           E
Sbjct: 675 E 675


>gi|24307967 SLIT-ROBO Rho GTPase activating protein 3 isoform a
           [Homo sapiens]
          Length = 1099

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 53/181 (29%), Positives = 92/181 (50%), Gaps = 6/181 (3%)

Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
           IP++V  C+ YI   GL  +GI+R  G   +   +  S  +    +   + E+ ++ V+ 
Sbjct: 519 IPLVVESCIRYINLYGLQQQGIFRVPGSQVEVNDIKNSFERGEDPLVDDQNERDINSVAG 578

Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
            LK + R L + LF + +    +   ++E+  E+V + +++LV LP V    ++ L + L
Sbjct: 579 VLKLYFRGLENPLFPKERFQDLISTIKLENPAERVHQIQQILVTLPRVVIVVMRYLFAFL 638

Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQ-TDGQD-----YKAGRVVEDLINHYVVVFSVDE 837
             +  +SD N M+ +NLAI FGPTL    DGQD          V++ +I H+  +F    
Sbjct: 639 NHLSQYSDENMMDPYNLAICFGPTLMHIPDGQDPVSCQAHINEVIKTIIIHHEAIFPSPR 698

Query: 838 E 838
           E
Sbjct: 699 E 699


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 65/238 (27%), Positives = 114/238 (47%), Gaps = 19/238 (7%)

Query: 591 EGPCEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMGWLGAIQKA---- 646
           E PC E    + L E+   GD +     +     +  +    + D   W+ +I++     
Sbjct: 72  EHPCNEENPGKFLFEVVPGGDRDR----MTANHESYLLMASTQNDMEDWVKSIRRVIWGP 127

Query: 647 ------AASMGDTLS-EQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLL 699
                    + DT+  E++ G+   P++V +CVD+I Q GL  EG++R  GQ +  + L 
Sbjct: 128 FGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQ 187

Query: 700 ESLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLTWLEASEI--EDEEEK 757
           ++   D       +    V  V+S LK +LR+LP+ +   A+   +L  +++  ++EE  
Sbjct: 188 DAF--DCGEKPSFDSNTDVHTVASLLKLYLRELPEPVIPYAKYEDFLSCAKLLSKEEEAG 245

Query: 758 VSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQD 815
           V    + +  LP VN   +K +   L  VQ +S  N+M+V NLA VFGP + +   +D
Sbjct: 246 VKELAKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSVQNLATVFGPNILRPKVED 303



 Score = 30.8 bits (68), Expect = 7.6
 Identities = 27/110 (24%), Positives = 39/110 (35%), Gaps = 8/110 (7%)

Query: 466 RWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFEVYTEGER----- 520
           RW VL    L YF++E    P G I          P  + +  +  FEV   G+R     
Sbjct: 39  RWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSEHPCNEENPGKFLFEVVPGGDRDRMTA 98

Query: 521 ---LYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAG 567
               YL    +     +WVK I +    P    +  +  E   R   + G
Sbjct: 99  NHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYG 148


>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
          Length = 786

 Score = 85.5 bits (210), Expect = 3e-16
 Identities = 62/218 (28%), Positives = 106/218 (48%), Gaps = 16/218 (7%)

Query: 631 ERRLDFMGWLGAIQKAAASMGDTLSEQQLGDSDIP----VIVYRCVDYITQCGLTSEGIY 686
           E R  ++  LG  +  + S    +  +  G++ +      I+ +C+  +   G+  +G+Y
Sbjct: 358 EERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIRKCISAVETRGINDQGLY 417

Query: 687 RKCGQTSKTQRLLESLRQDARSVHLKEGEQHVD----DVSSALKRFLRDLPDGLFTRAQR 742
           R  G +SK QRLL S+  D ++ +  + E   D     ++SALK++LR LP+ L T    
Sbjct: 418 RVVGVSSKVQRLL-SMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELH 476

Query: 743 LTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAI 802
             ++  ++    E +V+    L+ +LP  N+  +  L+ HL  V   S  N M V NL +
Sbjct: 477 GDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGV 536

Query: 803 VFGPTLFQTDGQDYKA-------GRVVEDLINHYVVVF 833
           VFGPTL +   +   A         VVE LI ++  +F
Sbjct: 537 VFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIF 574


>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
          Length = 459

 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 56/178 (31%), Positives = 90/178 (50%), Gaps = 9/178 (5%)

Query: 665 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVSS 723
           P++V  C+  I   GL SEG+YR  G +   + +  +  +D     +     + ++ ++ 
Sbjct: 282 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 341

Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
           ALK + RDLP  L T      ++E+++I D +E++    E L  LPP +  T++ L++HL
Sbjct: 342 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 401

Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAG--------RVVEDLINHYVVVF 833
             V      N MN  NL IVFGPTL ++   D  A          VVE LI +  ++F
Sbjct: 402 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 459


>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
          Length = 433

 Score = 84.7 bits (208), Expect = 4e-16
 Identities = 56/178 (31%), Positives = 90/178 (50%), Gaps = 9/178 (5%)

Query: 665 PVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGE-QHVDDVSS 723
           P++V  C+  I   GL SEG+YR  G +   + +  +  +D     +     + ++ ++ 
Sbjct: 256 PMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDGEKADISVNMYEDINIITG 315

Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
           ALK + RDLP  L T      ++E+++I D +E++    E L  LPP +  T++ L++HL
Sbjct: 316 ALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHL 375

Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAG--------RVVEDLINHYVVVF 833
             V      N MN  NL IVFGPTL ++   D  A          VVE LI +  ++F
Sbjct: 376 KRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDILF 433


>gi|5803145 ralA binding protein 1 [Homo sapiens]
          Length = 655

 Score = 84.0 bits (206), Expect = 8e-16
 Identities = 54/168 (32%), Positives = 88/168 (52%), Gaps = 3/168 (1%)

Query: 664 IPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLESLRQDARSVHLKEGEQHVDDVSS 723
           +P +   C+DY+ + G+  EGIYR  G  SK   L  +  ++  S +L++ E +   V+S
Sbjct: 209 LPAVFRECIDYVEKYGMKCEGIYRVSGIKSKVDELKAAYDRE-ESTNLEDYEPNT--VAS 265

Query: 724 ALKRFLRDLPDGLFTRAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHL 783
            LK++LRDLP+ L T+     + EA     E EKV  ++ LL  LP  N   +  LI H+
Sbjct: 266 LLKQYLRDLPENLLTKELMPRFEEACGRTTETEKVQEFQRLLKELPECNYLLISWLIVHM 325

Query: 784 YCVQCFSDTNQMNVHNLAIVFGPTLFQTDGQDYKAGRVVEDLINHYVV 831
             V       +MN+ N++IV  PT+  ++   Y     V++L  + V+
Sbjct: 326 DHVIAKELETKMNIQNISIVLSPTVQISNRVLYVFFTHVQELFGNVVL 373


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,257,853
Number of Sequences: 37866
Number of extensions: 2149529
Number of successful extensions: 7206
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 85
Number of HSP's that attempted gapping in prelim test: 6583
Number of HSP's gapped (non-prelim): 539
length of query: 1133
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1020
effective length of database: 13,968,660
effective search space: 14248033200
effective search space used: 14248033200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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