BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] (612 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 1261 0.0 gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 1248 0.0 gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 698 0.0 gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 383 e-106 gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 236 4e-62 gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 236 4e-62 gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 234 2e-61 gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 234 2e-61 gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 234 2e-61 gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 234 2e-61 gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 234 2e-61 gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 213 5e-55 gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 213 5e-55 gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 205 1e-52 gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 205 1e-52 gi|29725609 epidermal growth factor receptor isoform a precursor... 203 3e-52 gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 201 2e-51 gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 201 2e-51 gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 200 3e-51 gi|187475373 c-src tyrosine kinase [Homo sapiens] 196 4e-50 gi|4758078 c-src tyrosine kinase [Homo sapiens] 196 4e-50 gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50 gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 196 5e-50 gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50 gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50 gi|4503787 fyn-related kinase [Homo sapiens] 195 9e-50 gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 192 8e-49 gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 191 1e-48 gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 191 1e-48 gi|54792098 erbB-2 isoform b [Homo sapiens] 191 2e-48 >gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] Length = 612 Score = 1261 bits (3263), Expect = 0.0 Identities = 612/612 (100%), Positives = 612/612 (100%) Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK Sbjct: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF Sbjct: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120 Query: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ Sbjct: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180 Query: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL Sbjct: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240 Query: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY 300 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY Sbjct: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY 300 Query: 301 EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG 360 EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG Sbjct: 301 EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG 360 Query: 361 TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES 420 TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES Sbjct: 361 TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES 420 Query: 421 WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 480 WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV Sbjct: 421 WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 480 Query: 481 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW 540 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW Sbjct: 481 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW 540 Query: 541 EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 600 EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE Sbjct: 541 EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 600 Query: 601 LRLRNYYYDVVN 612 LRLRNYYYDVVN Sbjct: 601 LRLRNYYYDVVN 612 >gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] Length = 635 Score = 1248 bits (3229), Expect = 0.0 Identities = 612/635 (96%), Positives = 612/635 (96%), Gaps = 23/635 (3%) Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK Sbjct: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60 Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF Sbjct: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120 Query: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ Sbjct: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180 Query: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL Sbjct: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240 Query: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA------------------ 282 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA Sbjct: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300 Query: 283 -----SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 337 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP Sbjct: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 360 Query: 338 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 397 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE Sbjct: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420 Query: 398 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 457 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM Sbjct: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480 Query: 458 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 517 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA Sbjct: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540 Query: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE Sbjct: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600 Query: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 612 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN Sbjct: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635 >gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1 [Homo sapiens] Length = 619 Score = 698 bits (1802), Expect = 0.0 Identities = 342/608 (56%), Positives = 450/608 (74%), Gaps = 7/608 (1%) Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65 M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+ Sbjct: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60 Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125 IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++ Sbjct: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120 Query: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185 ++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G Sbjct: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180 Query: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245 ++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+ Sbjct: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240 Query: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPYEPELA 305 KADGL+ L C + N + P LP +HP S+ R+ T++ + Y PE A Sbjct: 241 LKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHP-STLTHPQRRIDTLNSDGYTPEPA 297 Query: 306 PWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKG 365 + P+ +PMDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G Sbjct: 298 RITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQG 355 Query: 366 YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVM 425 Y+M+K VA+K+LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVM Sbjct: 356 VYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVM 414 Query: 426 EMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY 484 EMA GPL+K+L R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HY Sbjct: 415 EMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474 Query: 485 AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS 544 AKISDFGLSKAL AD++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA S Sbjct: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS 534 Query: 545 YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 604 YGQKPY+ MKG EV A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R Sbjct: 535 YGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594 Query: 605 NYYYDVVN 612 YY + + Sbjct: 595 ACYYSLAS 602 >gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2 [Homo sapiens] Length = 312 Score = 383 bits (983), Expect = e-106 Identities = 183/296 (61%), Positives = 232/296 (78%), Gaps = 2/296 (0%) Query: 318 LPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVA 377 +PMDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G Y+M+K VA Sbjct: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60 Query: 378 VKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL 437 +K+LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L Sbjct: 61 IKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFL 119 Query: 438 QQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 496 R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL Sbjct: 120 VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL 179 Query: 497 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 556 AD++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG Sbjct: 180 GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP 239 Query: 557 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 612 EV A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R YY + + Sbjct: 240 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 295 >gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a [Homo sapiens] Length = 1130 Score = 236 bits (603), Expect = 4e-62 Identities = 149/440 (33%), Positives = 224/440 (50%), Gaps = 77/440 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 123 EKHSWYHGPVSRNAAEY--LLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282 GKL + +F+TL +LV H+S ADGL+ L P K +P + G P Sbjct: 181 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK---------RNKPTVYGVSP- 230 Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342 +++ +E E R + M ++ Y + E Sbjct: 231 -------------NYDKWEME-----------RTDITMKHKLGGGQYGEVYE-------- 258 Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402 G KK Y + VKT+ D +E L EA VM+ Sbjct: 259 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 291 Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459 ++ +P +V+++G+C E + ++ E G L YL++ + V ++ + Q+S M Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 351 Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519 +YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE Sbjct: 352 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 409 Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579 + Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++Y Sbjct: 410 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY 469 Query: 580 DLMNLCWTYDVENRPGFAAV 599 +LM CW ++ +RP FA + Sbjct: 470 ELMRACWQWNPSDRPSFAEI 489 Score = 50.4 bits (119), Expect = 5e-06 Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ G++ G +L+R+S + G ++S+ + + +HY I +G Sbjct: 127 WYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 184 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRP--QGVQPKTGPFE 121 ++ + A+L H+HS +DGL+ L P N+P GV P +E Sbjct: 185 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 236 >gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b [Homo sapiens] Length = 1149 Score = 236 bits (603), Expect = 4e-62 Identities = 149/440 (33%), Positives = 224/440 (50%), Gaps = 77/440 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 142 EKHSWYHGPVSRNAAEY--LLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282 GKL + +F+TL +LV H+S ADGL+ L P K +P + G P Sbjct: 200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK---------RNKPTVYGVSP- 249 Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342 +++ +E E R + M ++ Y + E Sbjct: 250 -------------NYDKWEME-----------RTDITMKHKLGGGQYGEVYE-------- 277 Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402 G KK Y + VKT+ D +E L EA VM+ Sbjct: 278 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 310 Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459 ++ +P +V+++G+C E + ++ E G L YL++ + V ++ + Q+S M Sbjct: 311 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 370 Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519 +YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE Sbjct: 371 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 428 Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579 + Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++Y Sbjct: 429 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY 488 Query: 580 DLMNLCWTYDVENRPGFAAV 599 +LM CW ++ +RP FA + Sbjct: 489 ELMRACWQWNPSDRPSFAEI 508 Score = 50.4 bits (119), Expect = 5e-06 Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ G++ G +L+R+S + G ++S+ + + +HY I +G Sbjct: 146 WYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 203 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRP--QGVQPKTGPFE 121 ++ + A+L H+HS +DGL+ L P N+P GV P +E Sbjct: 204 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 255 >gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] Length = 1167 Score = 234 bits (596), Expect = 2e-61 Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 154 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282 GK+ + +F TL +LV H+S ADGL+ L P K +P + G P Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 262 Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342 + R + T M ++ Y EVY+ Sbjct: 263 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 289 Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402 G KK Y + VKT+ D +E L EA VM+ Sbjct: 290 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 322 Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459 ++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382 Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519 +YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 440 Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579 + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500 Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609 +LM CW + +RP FA ++D Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530 Score = 49.7 bits (117), Expect = 8e-06 Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 158 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 215 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115 + ++ A+L H+HS +DGLV L P N+P GV P Sbjct: 216 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 261 >gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] Length = 1182 Score = 234 bits (596), Expect = 2e-61 Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 169 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282 GK+ + +F TL +LV H+S ADGL+ L P K +P + G P Sbjct: 227 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 277 Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342 + R + T M ++ Y EVY+ Sbjct: 278 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 304 Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402 G KK Y + VKT+ D +E L EA VM+ Sbjct: 305 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 337 Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459 ++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M Sbjct: 338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 397 Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519 +YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE Sbjct: 398 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 455 Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579 + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y Sbjct: 456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 515 Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609 +LM CW + +RP FA ++D Sbjct: 516 ELMRACWKWSPADRPSFAETHQAFETMFHD 545 Score = 49.7 bits (117), Expect = 8e-06 Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 173 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 230 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115 + ++ A+L H+HS +DGLV L P N+P GV P Sbjct: 231 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 276 >gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] Length = 542 Score = 234 bits (596), Expect = 2e-61 Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 148 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 205 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282 GK+ + +F TL +LV H+S ADGL+ L P K +P + G P Sbjct: 206 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 256 Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342 + R + T M ++ Y EVY+ Sbjct: 257 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 283 Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402 G KK Y + VKT+ D +E L EA VM+ Sbjct: 284 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 316 Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459 ++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M Sbjct: 317 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 376 Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519 +YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE Sbjct: 377 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 434 Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579 + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y Sbjct: 435 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 494 Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609 +LM CW + +RP FA ++D Sbjct: 495 ELMRACWKWSPADRPSFAETHQAFETMFHD 524 Score = 49.7 bits (117), Expect = 8e-06 Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 152 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 209 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115 + ++ A+L H+HS +DGLV L P N+P GV P Sbjct: 210 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 255 >gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] Length = 1064 Score = 234 bits (596), Expect = 2e-61 Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 154 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282 GK+ + +F TL +LV H+S ADGL+ L P K +P + G P Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 262 Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342 + R + T M ++ Y EVY+ Sbjct: 263 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 289 Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402 G KK Y + VKT+ D +E L EA VM+ Sbjct: 290 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 322 Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459 ++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382 Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519 +YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 440 Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579 + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500 Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609 +LM CW + +RP FA ++D Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530 Score = 49.7 bits (117), Expect = 8e-06 Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 158 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 215 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115 + ++ A+L H+HS +DGLV L P N+P GV P Sbjct: 216 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 261 >gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] Length = 1146 Score = 234 bits (596), Expect = 2e-61 Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+ Sbjct: 133 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 190 Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282 GK+ + +F TL +LV H+S ADGL+ L P K +P + G P Sbjct: 191 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 241 Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342 + R + T M ++ Y EVY+ Sbjct: 242 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 268 Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402 G KK Y + VKT+ D +E L EA VM+ Sbjct: 269 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 301 Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459 ++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M Sbjct: 302 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 361 Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519 +YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE Sbjct: 362 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 419 Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579 + Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y Sbjct: 420 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 479 Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609 +LM CW + +RP FA ++D Sbjct: 480 ELMRACWKWSPADRPSFAETHQAFETMFHD 509 Score = 49.7 bits (117), Expect = 8e-06 Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%) Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74 ++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G Sbjct: 137 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 194 Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115 + ++ A+L H+HS +DGLV L P N+P GV P Sbjct: 195 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 240 >gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] Length = 1074 Score = 213 bits (541), Expect = 5e-55 Identities = 112/285 (39%), Positives = 167/285 (58%), Gaps = 13/285 (4%) Query: 321 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVK 379 + + Y P EI+ + + L R + G G FG V +G Y + VA+K Sbjct: 425 EEDTYTMPSTRDYEIQRERIELGRCI--------GEGQFGDVHQGIYMSPENPALAVAIK 476 Query: 380 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 439 KN +D +++++ L EA M+Q D+P+IV++IG+ ++ME+ LG L +LQ Sbjct: 477 TCKNCTSD-SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV 535 Query: 440 NRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 498 ++ D ++I +Q+S + YLE FVHRD+AARNVL+ + K+ DFGLS+ + Sbjct: 536 RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME- 594 Query: 499 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 558 D YYKA + GK P+KW APE IN+ +F+S SDVW FGV MWE +G KP++G+K ++V Sbjct: 595 DSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 653 Query: 559 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 603 +E GER+ P CP +Y LM CW YD RP F ++ +L Sbjct: 654 IGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL 698 >gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] Length = 1052 Score = 213 bits (541), Expect = 5e-55 Identities = 112/285 (39%), Positives = 167/285 (58%), Gaps = 13/285 (4%) Query: 321 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVK 379 + + Y P EI+ + + L R + G G FG V +G Y + VA+K Sbjct: 403 EEDTYTMPSTRDYEIQRERIELGRCI--------GEGQFGDVHQGIYMSPENPALAVAIK 454 Query: 380 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 439 KN +D +++++ L EA M+Q D+P+IV++IG+ ++ME+ LG L +LQ Sbjct: 455 TCKNCTSD-SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV 513 Query: 440 NRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 498 ++ D ++I +Q+S + YLE FVHRD+AARNVL+ + K+ DFGLS+ + Sbjct: 514 RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME- 572 Query: 499 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 558 D YYKA + GK P+KW APE IN+ +F+S SDVW FGV MWE +G KP++G+K ++V Sbjct: 573 DSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 631 Query: 559 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 603 +E GER+ P CP +Y LM CW YD RP F ++ +L Sbjct: 632 IGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL 676 >gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-2 precursor [Homo sapiens] Length = 1292 Score = 205 bits (521), Expect = 1e-52 Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%) Query: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409 K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++ Sbjct: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780 Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468 VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840 Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528 HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+ Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899 Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588 +SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW Sbjct: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959 Query: 589 DVENRPGF 596 D ++RP F Sbjct: 960 DADSRPKF 967 >gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4 isoform JM-a/CVT-1 precursor [Homo sapiens] Length = 1308 Score = 205 bits (521), Expect = 1e-52 Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%) Query: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409 K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++ Sbjct: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780 Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468 VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840 Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528 HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+ Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899 Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588 +SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW Sbjct: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959 Query: 589 DVENRPGF 596 D ++RP F Sbjct: 960 DADSRPKF 967 >gi|29725609 epidermal growth factor receptor isoform a precursor [Homo sapiens] Length = 1210 Score = 203 bits (517), Expect = 3e-52 Identities = 107/248 (43%), Positives = 161/248 (64%), Gaps = 5/248 (2%) Query: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409 K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++ Sbjct: 716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 774 Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468 R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ V Sbjct: 775 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 834 Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528 HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++ Sbjct: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG-GKVPIKWMALESILHRIYTH 893 Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588 +SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW Sbjct: 894 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 953 Query: 589 DVENRPGF 596 D ++RP F Sbjct: 954 DADSRPKF 961 >gi|112789548 lymphocyte-specific protein tyrosine kinase precursor [Homo sapiens] Length = 509 Score = 201 bits (510), Expect = 2e-51 Identities = 145/450 (32%), Positives = 219/450 (48%), Gaps = 80/450 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 E PWF +SR+++E+ +L T+G FLIR ++ GS++L + Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV--------------- 167 Query: 223 TGKLSIPEGKKFD-TLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL--PGS 279 + FD ++V+HY KI N F P++ PG Sbjct: 168 ---------RDFDQNQGEVVKHY----------------KIRNLDNGGFYISPRITFPGL 202 Query: 280 HPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKE 339 H A+D R + P T+ + P+ + E P+E Sbjct: 203 HELVRHYTN-------------------ASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRE 243 Query: 340 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 399 KL+ + LG+G FG V GYY VAVK LK + P D LAEAN Sbjct: 244 TL---KLV----ERLGAGQFGEVWMGYYNGHT---KVAVKSLKQGSMSP---DAFLAEAN 290 Query: 400 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVK--DKNIIELVHQVSM 457 +M+QL + +VR+ + E ++ E E G L +L+ +K ++++ Q++ Sbjct: 291 LMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 350 Query: 458 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 517 GM ++EE N++HRDL A N+L+ KI+DFGL++ + ++N Y A+ K+P+KW A Sbjct: 351 GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTA 408 Query: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577 PE INY F+ KSDVWSFG+L+ E ++G+ PY GM EV LE+G RM P CP E Sbjct: 409 PEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEE 468 Query: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 607 +Y LM LCW E+RP F + L +++ Sbjct: 469 LYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498 Score = 58.5 bits (140), Expect = 2e-08 Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 5/114 (4%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA-----HGRKA 61 A+S P+FF N++R++AE L+ G + G +L+R+S + G F+LSV G Sbjct: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQP 115 HY I NG + I+ T +L +++ SDGL L +P + +P Sbjct: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232 >gi|112789546 lymphocyte-specific protein tyrosine kinase precursor [Homo sapiens] Length = 509 Score = 201 bits (510), Expect = 2e-51 Identities = 145/450 (32%), Positives = 219/450 (48%), Gaps = 80/450 (17%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222 E PWF +SR+++E+ +L T+G FLIR ++ GS++L + Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV--------------- 167 Query: 223 TGKLSIPEGKKFD-TLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL--PGS 279 + FD ++V+HY KI N F P++ PG Sbjct: 168 ---------RDFDQNQGEVVKHY----------------KIRNLDNGGFYISPRITFPGL 202 Query: 280 HPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKE 339 H A+D R + P T+ + P+ + E P+E Sbjct: 203 HELVRHYTN-------------------ASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRE 243 Query: 340 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 399 KL+ + LG+G FG V GYY VAVK LK + P D LAEAN Sbjct: 244 TL---KLV----ERLGAGQFGEVWMGYYNGHT---KVAVKSLKQGSMSP---DAFLAEAN 290 Query: 400 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVK--DKNIIELVHQVSM 457 +M+QL + +VR+ + E ++ E E G L +L+ +K ++++ Q++ Sbjct: 291 LMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 350 Query: 458 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 517 GM ++EE N++HRDL A N+L+ KI+DFGL++ + ++N Y A+ K+P+KW A Sbjct: 351 GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTA 408 Query: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577 PE INY F+ KSDVWSFG+L+ E ++G+ PY GM EV LE+G RM P CP E Sbjct: 409 PEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEE 468 Query: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 607 +Y LM LCW E+RP F + L +++ Sbjct: 469 LYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498 Score = 58.5 bits (140), Expect = 2e-08 Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 5/114 (4%) Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA-----HGRKA 61 A+S P+FF N++R++AE L+ G + G +L+R+S + G F+LSV G Sbjct: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178 Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQP 115 HY I NG + I+ T +L +++ SDGL L +P + +P Sbjct: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232 >gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] Length = 526 Score = 200 bits (509), Expect = 3e-51 Identities = 144/454 (31%), Positives = 211/454 (46%), Gaps = 88/454 (19%) Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLL-----HEGKVLHYR 217 E WF ISR+++E+ +L G F+IR + GSY+L + V HY+ Sbjct: 140 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 199 Query: 218 IDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLP 277 I G I F TL +LV+HY DGL CQK+ Sbjct: 200 IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGL-------CQKL--------------- 237 Query: 278 GSHPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 337 S P ++ + PW D +E P Sbjct: 238 -----SVPCMSSKPQK------------PWEKD-------------AWEIP--------- 258 Query: 338 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM--KKVVKTVAVKILKNEANDPALKDELL 395 R+ L LE K+LG+G FG V Y K VKT+ + EA L Sbjct: 259 ------RESLKLE-KKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEA--------FL 303 Query: 396 AEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDK--NIIELVH 453 AEANVM+ L + +V++ + E ++ E G L +L+ + K +I+ Sbjct: 304 AEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSA 363 Query: 454 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 513 Q++ GM ++E+ N++HRDL A N+L+ KI+DFGL++ + ++N Y A+ K+P+ Sbjct: 364 QIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPI 421 Query: 514 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG 573 KW APE IN+ F+ KSDVWSFG+L+ E +YG+ PY GM EV LE+G RM P Sbjct: 422 KWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN 481 Query: 574 CPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 607 CP E+Y++M CW E RP F ++ L ++Y Sbjct: 482 CPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFY 515 Score = 47.8 bits (112), Expect = 3e-05 Identities = 48/191 (25%), Positives = 80/191 (41%), Gaps = 22/191 (11%) Query: 8 DSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKAH 62 DS +FF I+R++AE L+ G G +++R S G ++LSV G Sbjct: 137 DSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVK 196 Query: 63 HYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP--FNRPQGVQPKTG-- 118 HY I NG + I+ T ++ +L ++ + +DGL L P ++PQ K Sbjct: 197 HYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWE 256 Query: 119 -PFEDLK------ENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIA------TTAHEK 165 P E LK E T+N + + + +E +A T H+K Sbjct: 257 IPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDK 316 Query: 166 MPWFHGKISRE 176 + H +++E Sbjct: 317 LVKLHAVVTKE 327 >gi|187475373 c-src tyrosine kinase [Homo sapiens] Length = 450 Score = 196 bits (499), Expect = 4e-50 Identities = 160/456 (35%), Positives = 218/456 (47%), Gaps = 87/456 (19%) Query: 155 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKV 213 E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ +GK Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCDGK- 125 Query: 214 LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR 273 VEHY + K+ V F Sbjct: 126 ---------------------------VEHYR---------IMYHASKLSIDEEVYFENL 149 Query: 274 PQLPGSHPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPE 333 QL + +S A G T P E A D E Y S +A Sbjct: 150 MQLVEHY--TSDADGL---CTRLIKPKVMEGTVAAQD------------EFYRSGWA--- 189 Query: 334 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 393 + KE+ KLL + +G G FG V G Y+ KV AVK +KN+A A Sbjct: 190 -LNMKEL----KLL----QTIGKGEFGDVMLGDYRGNKV----AVKCIKNDATAQAF--- 233 Query: 394 LLAEANVMQQLDNPYIVRMIGICEAESWML--VMEMAELGPLNKYLQ-QNRHVKDKN-II 449 LAEA+VM QL + +V+++G+ E L V E G L YL+ + R V + ++ Sbjct: 234 -LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 Query: 450 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 509 + V M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K + Q G Sbjct: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS------TQDTG 346 Query: 510 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 569 K PVKW APE + KFS+KSDVWSFG+L+WE +S+G+ PY + +V +EKG +M Sbjct: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 Query: 570 CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 605 P GCP +Y++M CW D RP F + +L + Sbjct: 407 APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH 442 Score = 47.8 bits (112), Expect = 3e-05 Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 3/94 (3%) Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 +P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I + Sbjct: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS- 136 Query: 73 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 +I + L +++ ++DGL L KP Sbjct: 137 KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP 170 >gi|4758078 c-src tyrosine kinase [Homo sapiens] Length = 450 Score = 196 bits (499), Expect = 4e-50 Identities = 160/456 (35%), Positives = 218/456 (47%), Gaps = 87/456 (19%) Query: 155 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKV 213 E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ +GK Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCDGK- 125 Query: 214 LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR 273 VEHY + K+ V F Sbjct: 126 ---------------------------VEHYR---------IMYHASKLSIDEEVYFENL 149 Query: 274 PQLPGSHPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPE 333 QL + +S A G T P E A D E Y S +A Sbjct: 150 MQLVEHY--TSDADGL---CTRLIKPKVMEGTVAAQD------------EFYRSGWA--- 189 Query: 334 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 393 + KE+ KLL + +G G FG V G Y+ KV AVK +KN+A A Sbjct: 190 -LNMKEL----KLL----QTIGKGEFGDVMLGDYRGNKV----AVKCIKNDATAQAF--- 233 Query: 394 LLAEANVMQQLDNPYIVRMIGICEAESWML--VMEMAELGPLNKYLQ-QNRHVKDKN-II 449 LAEA+VM QL + +V+++G+ E L V E G L YL+ + R V + ++ Sbjct: 234 -LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292 Query: 450 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 509 + V M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K + Q G Sbjct: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS------TQDTG 346 Query: 510 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 569 K PVKW APE + KFS+KSDVWSFG+L+WE +S+G+ PY + +V +EKG +M Sbjct: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406 Query: 570 CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 605 P GCP +Y++M CW D RP F + +L + Sbjct: 407 APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH 442 Score = 47.8 bits (112), Expect = 3e-05 Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 3/94 (3%) Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72 +P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I + Sbjct: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS- 136 Query: 73 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 +I + L +++ ++DGL L KP Sbjct: 137 KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP 170 >gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo sapiens] Length = 1009 Score = 196 bits (498), Expect = 5e-50 Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%) Query: 354 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412 LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++ Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489 Query: 413 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 471 IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549 Query: 472 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 531 +A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607 Query: 532 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 591 VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667 Query: 592 NRPGFAAVELRLRNYY 607 +RP F + L + Y Sbjct: 668 DRPRFTELVCSLSDVY 683 >gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo sapiens] Length = 967 Score = 196 bits (498), Expect = 5e-50 Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%) Query: 354 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412 LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++ Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489 Query: 413 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 471 IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549 Query: 472 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 531 +A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607 Query: 532 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 591 VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667 Query: 592 NRPGFAAVELRLRNYY 607 +RP F + L + Y Sbjct: 668 DRPRFTELVCSLSDVY 683 >gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo sapiens] Length = 1009 Score = 196 bits (498), Expect = 5e-50 Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%) Query: 354 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412 LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++ Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489 Query: 413 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 471 IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549 Query: 472 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 531 +A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607 Query: 532 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 591 VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667 Query: 592 NRPGFAAVELRLRNYY 607 +RP F + L + Y Sbjct: 668 DRPRFTELVCSLSDVY 683 >gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo sapiens] Length = 1009 Score = 196 bits (498), Expect = 5e-50 Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%) Query: 354 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412 LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++ Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489 Query: 413 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 471 IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549 Query: 472 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 531 +A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607 Query: 532 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 591 VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667 Query: 592 NRPGFAAVELRLRNYY 607 +RP F + L + Y Sbjct: 668 DRPRFTELVCSLSDVY 683 >gi|4503787 fyn-related kinase [Homo sapiens] Length = 505 Score = 195 bits (496), Expect = 9e-50 Identities = 106/270 (39%), Positives = 164/270 (60%), Gaps = 11/270 (4%) Query: 342 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 401 +DR + L K LGSG FG V +G + VAVK LK + DP ++ L EA +M Sbjct: 229 IDRNSIQLL-KRLGSGQFGEVWEGLWNN---TTPVAVKTLKPGSMDP---NDFLREAQIM 281 Query: 402 QQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDK--NIIELVHQVSMG 458 + L +P ++++ +C E + ++ E+ G L +YLQ + K +++ QV+ G Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341 Query: 459 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD-ENYYKAQTHGKWPVKWYA 517 M YLE N++HRDLAARNVL+ + K++DFGL++ + D E+ Y+++ K PVKW A Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401 Query: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577 PE I KFS KSDVWSFG+L++E +YG+ PY GM G++V ML + R+ P+ CP++ Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461 Query: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 607 Y++M CW + + RP F + +L +Y+ Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF 491 Score = 65.5 bits (158), Expect = 1e-10 Identities = 36/97 (37%), Positives = 51/97 (52%), Gaps = 1/97 (1%) Query: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGK 225 PWF G I R ++E+ +L G FLIR ++ G ++L +L V HYRI + G Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174 Query: 226 LSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKI 262 + + F TL + V HY+ +DGL L PC KI Sbjct: 175 FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKI 211 Score = 58.2 bits (139), Expect = 2e-08 Identities = 32/93 (34%), Positives = 50/93 (53%) Query: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73 P+FFG I R +AE L+ G +L+R+S + G F+LSV G HY I+R G Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174 Query: 74 YAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106 + + R ++ + ++++ SDGL L KP Sbjct: 175 FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKP 207 >gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] Length = 984 Score = 192 bits (488), Expect = 8e-49 Identities = 112/305 (36%), Positives = 176/305 (57%), Gaps = 10/305 (3%) Query: 300 YEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNF 359 Y +L ++ +G + +D YE P E +R +D + +E+ +G+G F Sbjct: 575 YSDKLQHYSTGRGSPGMKIYIDPFTYEDPN---EAVREFAKEIDVSFVKIEEV-IGAGEF 630 Query: 360 GTVKKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-E 417 G V KG ++ K VA+K LK ++ +D L+EA++M Q D+P I+R+ G+ + Sbjct: 631 GEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRD-FLSEASIMGQFDHPNIIRLEGVVTK 689 Query: 418 AESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARN 476 + M++ E E G L+ +L+QN ++ ++ ++ GMKYL E N+VHRDLAARN Sbjct: 690 SRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARN 749 Query: 477 VLLVTQHYAKISDFGLSKALRADEN--YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWS 534 +L+ + K+SDFGLS+ L+ D + Y + GK PV+W APE I Y KF+S SDVWS Sbjct: 750 ILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWS 809 Query: 535 FGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 594 +G++MWE S+G++PY M +V +E+ R+ P CP ++ LM CW D +RP Sbjct: 810 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRP 869 Query: 595 GFAAV 599 FA + Sbjct: 870 RFAEI 874 >gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sapiens] Length = 1038 Score = 191 bits (486), Expect = 1e-48 Identities = 100/252 (39%), Positives = 151/252 (59%), Gaps = 4/252 (1%) Query: 352 KELGSGNFGTVKKGYYQMKK-VVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYI 409 ++LG G+FG V++G + +VAVK LK + + P D+ + E N M LD+ + Sbjct: 130 EKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNL 189 Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468 +R+ G+ +V E+A LG L L++++ H + QV+ GM YLE F+ Sbjct: 190 IRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFI 249 Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528 HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W APE + FS Sbjct: 250 HRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSH 309 Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCWT 587 SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP+++Y++M CW Sbjct: 310 ASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWA 369 Query: 588 YDVENRPGFAAV 599 + E+RP F A+ Sbjct: 370 HKPEDRPTFVAL 381 >gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sapiens] Length = 1086 Score = 191 bits (486), Expect = 1e-48 Identities = 100/252 (39%), Positives = 151/252 (59%), Gaps = 4/252 (1%) Query: 352 KELGSGNFGTVKKGYYQMKK-VVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYI 409 ++LG G+FG V++G + +VAVK LK + + P D+ + E N M LD+ + Sbjct: 193 EKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNL 252 Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468 +R+ G+ +V E+A LG L L++++ H + QV+ GM YLE F+ Sbjct: 253 IRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFI 312 Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528 HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W APE + FS Sbjct: 313 HRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSH 372 Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCWT 587 SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP+++Y++M CW Sbjct: 373 ASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWA 432 Query: 588 YDVENRPGFAAV 599 + E+RP F A+ Sbjct: 433 HKPEDRPTFVAL 444 >gi|54792098 erbB-2 isoform b [Homo sapiens] Length = 1225 Score = 191 bits (485), Expect = 2e-48 Identities = 105/248 (42%), Positives = 153/248 (61%), Gaps = 5/248 (2%) Query: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409 K LGSG FGTV KG + + V VA+K+L+ E P E+L EA VM + +PY+ Sbjct: 694 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGVGSPYV 752 Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468 R++GIC + LV ++ G L ++++NR + ++++ Q++ GM YLE+ V Sbjct: 753 SRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLV 812 Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528 HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A E I +F+ Sbjct: 813 HRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADG-GKVPIKWMALESILRRRFTH 871 Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588 +SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW Sbjct: 872 QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMI 931 Query: 589 DVENRPGF 596 D E RP F Sbjct: 932 DSECRPRF 939 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.135 0.408 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 24,249,107 Number of Sequences: 37866 Number of extensions: 1161749 Number of successful extensions: 4901 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 649 Number of HSP's successfully gapped in prelim test: 227 Number of HSP's that attempted gapping in prelim test: 3018 Number of HSP's gapped (non-prelim): 1137 length of query: 612 length of database: 18,247,518 effective HSP length: 108 effective length of query: 504 effective length of database: 14,157,990 effective search space: 7135626960 effective search space used: 7135626960 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.