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Search of human proteins with 205277435
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
(612 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 1261 0.0
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 1248 0.0
gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1... 698 0.0
gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2... 383 e-106
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 236 4e-62
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 236 4e-62
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 234 2e-61
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 234 2e-61
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 234 2e-61
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 234 2e-61
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 234 2e-61
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens] 213 5e-55
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens] 213 5e-55
gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homo... 205 1e-52
gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolo... 205 1e-52
gi|29725609 epidermal growth factor receptor isoform a precursor... 203 3e-52
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 201 2e-51
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 201 2e-51
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 200 3e-51
gi|187475373 c-src tyrosine kinase [Homo sapiens] 196 4e-50
gi|4758078 c-src tyrosine kinase [Homo sapiens] 196 4e-50
gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50
gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo... 196 5e-50
gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50
gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo... 196 5e-50
gi|4503787 fyn-related kinase [Homo sapiens] 195 9e-50
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 192 8e-49
gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo sap... 191 1e-48
gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo sap... 191 1e-48
gi|54792098 erbB-2 isoform b [Homo sapiens] 191 2e-48
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 1261 bits (3263), Expect = 0.0
Identities = 612/612 (100%), Positives = 612/612 (100%)
Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
Sbjct: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60
Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
Sbjct: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120
Query: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
Sbjct: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180
Query: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
Sbjct: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240
Query: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY 300
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY
Sbjct: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPY 300
Query: 301 EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG 360
EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG
Sbjct: 301 EPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFG 360
Query: 361 TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES 420
TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES
Sbjct: 361 TVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAES 420
Query: 421 WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 480
WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV
Sbjct: 421 WMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLV 480
Query: 481 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW 540
TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW
Sbjct: 481 TQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMW 540
Query: 541 EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 600
EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE
Sbjct: 541 EAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVE 600
Query: 601 LRLRNYYYDVVN 612
LRLRNYYYDVVN
Sbjct: 601 LRLRNYYYDVVN 612
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 1248 bits (3229), Expect = 0.0
Identities = 612/635 (96%), Positives = 612/635 (96%), Gaps = 23/635 (3%)
Query: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK
Sbjct: 1 MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRK 60
Query: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120
AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF
Sbjct: 61 AHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPF 120
Query: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180
EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ
Sbjct: 121 EDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQ 180
Query: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240
IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL
Sbjct: 181 IVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQL 240
Query: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA------------------ 282
VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA
Sbjct: 241 VEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPK 300
Query: 283 -----SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 337
SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP
Sbjct: 301 PGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 360
Query: 338 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 397
KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE
Sbjct: 361 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAE 420
Query: 398 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 457
ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM
Sbjct: 421 ANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSM 480
Query: 458 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 517
GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA
Sbjct: 481 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 540
Query: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577
PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE
Sbjct: 541 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 600
Query: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 612
MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Sbjct: 601 MYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 635
>gi|31455611 zeta-chain associated protein kinase 70kDa isoform 1
[Homo sapiens]
Length = 619
Score = 698 bits (1802), Expect = 0.0
Identities = 342/608 (56%), Positives = 450/608 (74%), Gaps = 7/608 (1%)
Query: 6 MADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYT 65
M D A HLPFF+G+I+R EAE++L GM+DGL+LLRQ LGG+ LS+ H + HH+
Sbjct: 1 MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP 60
Query: 66 IERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKE 125
IER+LNGTYAIAGG+ H PA+LC ++S++ DGL C L+KP NRP G++P+ G F+ L++
Sbjct: 61 IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD 120
Query: 126 NLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIG 185
++R+YV+QTW L+G+ALEQAIISQ PQ+EKLIATTAHE+MPW+H ++REE+E+ + G
Sbjct: 121 AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG 180
Query: 186 SKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYS 245
++T+GKFL+R R G+YAL L++ V HY I +DK GK IPEG KFDTLWQLVE+
Sbjct: 181 AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK 240
Query: 246 YKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPASSPAQGNRQESTVSFNPYEPELA 305
KADGL+ L C + N + P LP +HP S+ R+ T++ + Y PE A
Sbjct: 241 LKADGLIYCLKEACPN-SSASNASGAAAPTLP-AHP-STLTHPQRRIDTLNSDGYTPEPA 297
Query: 306 PWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKG 365
+ P+ +PMDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G
Sbjct: 298 RITSPDKPR--PMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQG 355
Query: 366 YYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVM 425
Y+M+K VA+K+LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVM
Sbjct: 356 VYRMRKKQIDVAIKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVM 414
Query: 426 EMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHY 484
EMA GPL+K+L R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HY
Sbjct: 415 EMAGGGPLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHY 474
Query: 485 AKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFS 544
AKISDFGLSKAL AD++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA S
Sbjct: 475 AKISDFGLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALS 534
Query: 545 YGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLR 604
YGQKPY+ MKG EV A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R
Sbjct: 535 YGQKPYKKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMR 594
Query: 605 NYYYDVVN 612
YY + +
Sbjct: 595 ACYYSLAS 602
>gi|46488944 zeta-chain associated protein kinase 70kDa isoform 2
[Homo sapiens]
Length = 312
Score = 383 bits (983), Expect = e-106
Identities = 183/296 (61%), Positives = 232/296 (78%), Gaps = 2/296 (0%)
Query: 318 LPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVA 377
+PMDT VYESPY+DPEE++ K+++L R L + D ELG GNFG+V++G Y+M+K VA
Sbjct: 1 MPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMRKKQIDVA 60
Query: 378 VKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYL 437
+K+LK + + A +E++ EA +M QLDNPYIVR+IG+C+AE+ MLVMEMA GPL+K+L
Sbjct: 61 IKVLK-QGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGGPLHKFL 119
Query: 438 QQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKAL 496
R + N+ EL+HQVSMGMKYLEE NFVHRDLAARNVLLV +HYAKISDFGLSKAL
Sbjct: 120 VGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKAL 179
Query: 497 RADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGS 556
AD++YY A++ GKWP+KWYAPECIN+ KFSS+SDVWS+GV MWEA SYGQKPY+ MKG
Sbjct: 180 GADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPYKKMKGP 239
Query: 557 EVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN 612
EV A +E+G+RM CP CP E+Y LM+ CW Y E+RP F VE R+R YY + +
Sbjct: 240 EVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSLAS 295
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 236 bits (603), Expect = 4e-62
Identities = 149/440 (33%), Positives = 224/440 (50%), Gaps = 77/440 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 123 EKHSWYHGPVSRNAAEY--LLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 180
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282
GKL + +F+TL +LV H+S ADGL+ L P K +P + G P
Sbjct: 181 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK---------RNKPTVYGVSP- 230
Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342
+++ +E E R + M ++ Y + E
Sbjct: 231 -------------NYDKWEME-----------RTDITMKHKLGGGQYGEVYE-------- 258
Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402
G KK Y + VKT+ D +E L EA VM+
Sbjct: 259 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 291
Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459
++ +P +V+++G+C E + ++ E G L YL++ + V ++ + Q+S M
Sbjct: 292 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 351
Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519
+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE
Sbjct: 352 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 409
Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579
+ Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++Y
Sbjct: 410 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY 469
Query: 580 DLMNLCWTYDVENRPGFAAV 599
+LM CW ++ +RP FA +
Sbjct: 470 ELMRACWQWNPSDRPSFAEI 489
Score = 50.4 bits (119), Expect = 5e-06
Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ G++ G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 127 WYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 184
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRP--QGVQPKTGPFE 121
++ + A+L H+HS +DGL+ L P N+P GV P +E
Sbjct: 185 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 236
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 236 bits (603), Expect = 4e-62
Identities = 149/440 (33%), Positives = 224/440 (50%), Gaps = 77/440 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 142 EKHSWYHGPVSRNAAEY--LLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTAS 199
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282
GKL + +F+TL +LV H+S ADGL+ L P K +P + G P
Sbjct: 200 DGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPK---------RNKPTVYGVSP- 249
Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342
+++ +E E R + M ++ Y + E
Sbjct: 250 -------------NYDKWEME-----------RTDITMKHKLGGGQYGEVYE-------- 277
Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402
G KK Y + VKT+ D +E L EA VM+
Sbjct: 278 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 310
Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459
++ +P +V+++G+C E + ++ E G L YL++ + V ++ + Q+S M
Sbjct: 311 EIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAM 370
Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519
+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE
Sbjct: 371 EYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 428
Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579
+ Y KFS KSDVW+FGVL+WE +YG PY G+ S+V +LEK RM P GCP ++Y
Sbjct: 429 SLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVY 488
Query: 580 DLMNLCWTYDVENRPGFAAV 599
+LM CW ++ +RP FA +
Sbjct: 489 ELMRACWQWNPSDRPSFAEI 508
Score = 50.4 bits (119), Expect = 5e-06
Identities = 33/112 (29%), Positives = 60/112 (53%), Gaps = 7/112 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ G++ G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 146 WYHGPVSRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKL 203
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKPF---NRP--QGVQPKTGPFE 121
++ + A+L H+HS +DGL+ L P N+P GV P +E
Sbjct: 204 YVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWE 255
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 234 bits (596), Expect = 2e-61
Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 154 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282
GK+ + +F TL +LV H+S ADGL+ L P K +P + G P
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 262
Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342
+ R + T M ++ Y EVY+
Sbjct: 263 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 289
Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402
G KK Y + VKT+ D +E L EA VM+
Sbjct: 290 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 322
Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459
++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M
Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382
Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519
+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE
Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 440
Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579
+ Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609
+LM CW + +RP FA ++D
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 158 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 215
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 216 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 261
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 234 bits (596), Expect = 2e-61
Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 169 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 226
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282
GK+ + +F TL +LV H+S ADGL+ L P K +P + G P
Sbjct: 227 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 277
Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342
+ R + T M ++ Y EVY+
Sbjct: 278 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 304
Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402
G KK Y + VKT+ D +E L EA VM+
Sbjct: 305 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 337
Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459
++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M
Sbjct: 338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 397
Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519
+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE
Sbjct: 398 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 455
Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579
+ Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y
Sbjct: 456 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 515
Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609
+LM CW + +RP FA ++D
Sbjct: 516 ELMRACWKWSPADRPSFAETHQAFETMFHD 545
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 173 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 230
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 231 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 276
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 234 bits (596), Expect = 2e-61
Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 148 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 205
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282
GK+ + +F TL +LV H+S ADGL+ L P K +P + G P
Sbjct: 206 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 256
Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342
+ R + T M ++ Y EVY+
Sbjct: 257 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 283
Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402
G KK Y + VKT+ D +E L EA VM+
Sbjct: 284 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 316
Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459
++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M
Sbjct: 317 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 376
Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519
+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE
Sbjct: 377 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 434
Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579
+ Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y
Sbjct: 435 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 494
Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609
+LM CW + +RP FA ++D
Sbjct: 495 ELMRACWKWSPADRPSFAETHQAFETMFHD 524
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 152 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 209
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 210 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 255
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 234 bits (596), Expect = 2e-61
Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 154 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 211
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282
GK+ + +F TL +LV H+S ADGL+ L P K +P + G P
Sbjct: 212 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 262
Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342
+ R + T M ++ Y EVY+
Sbjct: 263 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 289
Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402
G KK Y + VKT+ D +E L EA VM+
Sbjct: 290 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 322
Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459
++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M
Sbjct: 323 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 382
Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519
+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE
Sbjct: 383 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 440
Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579
+ Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y
Sbjct: 441 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 500
Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609
+LM CW + +RP FA ++D
Sbjct: 501 ELMRACWKWSPADRPSFAETHQAFETMFHD 530
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 158 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 215
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 216 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 261
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 234 bits (596), Expect = 2e-61
Identities = 151/450 (33%), Positives = 221/450 (49%), Gaps = 77/450 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
EK W+HG +SR +E L+ S NG FL+R +++ G ++ L +EG+V HYRI+
Sbjct: 133 EKHSWYHGPVSRSAAEY--LLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTA 190
Query: 223 TGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPA 282
GK+ + +F TL +LV H+S ADGL+ L P K +P + G P
Sbjct: 191 DGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKC---------NKPTVYGVSPI 241
Query: 283 SSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYL 342
+ R + T M ++ Y EVY+
Sbjct: 242 HDKWEMERTDIT-------------------------MKHKLGGGQYG--------EVYV 268
Query: 343 DRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQ 402
G KK Y + VKT+ D +E L EA VM+
Sbjct: 269 -----------------GVWKK--YSLTVAVKTL--------KEDTMEVEEFLKEAAVMK 301
Query: 403 QLDNPYIVRMIGICEAE-SWMLVMEMAELGPLNKYLQQ--NRHVKDKNIIELVHQVSMGM 459
++ +P +V+++G+C E + +V E G L YL++ V ++ + Q+S M
Sbjct: 302 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAM 361
Query: 460 KYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519
+YLE+ NF+HRDLAARN L+ H K++DFGLS+ + D Y A K+P+KW APE
Sbjct: 362 EYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDT--YTAHAGAKFPIKWTAPE 419
Query: 520 CINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMY 579
+ Y FS KSDVW+FGVL+WE +YG PY G+ S+V +LEKG RM P GCP ++Y
Sbjct: 420 SLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVY 479
Query: 580 DLMNLCWTYDVENRPGFAAVELRLRNYYYD 609
+LM CW + +RP FA ++D
Sbjct: 480 ELMRACWKWSPADRPSFAETHQAFETMFHD 509
Score = 49.7 bits (117), Expect = 8e-06
Identities = 32/106 (30%), Positives = 57/106 (53%), Gaps = 7/106 (6%)
Query: 15 FFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTY 74
++ G ++R AE YL+ + +G +L+R+S + G ++S+ + + +HY I +G
Sbjct: 137 WYHGPVSRSAAE-YLLSS-LINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTADGKV 194
Query: 75 AIAGGRTHASPADLCHYHSQESDGLVCLLKKP---FNRP--QGVQP 115
+ ++ A+L H+HS +DGLV L P N+P GV P
Sbjct: 195 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP 240
>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
Length = 1074
Score = 213 bits (541), Expect = 5e-55
Identities = 112/285 (39%), Positives = 167/285 (58%), Gaps = 13/285 (4%)
Query: 321 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVK 379
+ + Y P EI+ + + L R + G G FG V +G Y + VA+K
Sbjct: 425 EEDTYTMPSTRDYEIQRERIELGRCI--------GEGQFGDVHQGIYMSPENPALAVAIK 476
Query: 380 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 439
KN +D +++++ L EA M+Q D+P+IV++IG+ ++ME+ LG L +LQ
Sbjct: 477 TCKNCTSD-SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV 535
Query: 440 NRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 498
++ D ++I +Q+S + YLE FVHRD+AARNVL+ + K+ DFGLS+ +
Sbjct: 536 RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME- 594
Query: 499 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 558
D YYKA + GK P+KW APE IN+ +F+S SDVW FGV MWE +G KP++G+K ++V
Sbjct: 595 DSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 653
Query: 559 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 603
+E GER+ P CP +Y LM CW YD RP F ++ +L
Sbjct: 654 IGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL 698
>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
Length = 1052
Score = 213 bits (541), Expect = 5e-55
Identities = 112/285 (39%), Positives = 167/285 (58%), Gaps = 13/285 (4%)
Query: 321 DTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM-KKVVKTVAVK 379
+ + Y P EI+ + + L R + G G FG V +G Y + VA+K
Sbjct: 403 EEDTYTMPSTRDYEIQRERIELGRCI--------GEGQFGDVHQGIYMSPENPALAVAIK 454
Query: 380 ILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQ 439
KN +D +++++ L EA M+Q D+P+IV++IG+ ++ME+ LG L +LQ
Sbjct: 455 TCKNCTSD-SVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQV 513
Query: 440 NRHVKD-KNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRA 498
++ D ++I +Q+S + YLE FVHRD+AARNVL+ + K+ DFGLS+ +
Sbjct: 514 RKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYME- 572
Query: 499 DENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEV 558
D YYKA + GK P+KW APE IN+ +F+S SDVW FGV MWE +G KP++G+K ++V
Sbjct: 573 DSTYYKA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDV 631
Query: 559 TAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRL 603
+E GER+ P CP +Y LM CW YD RP F ++ +L
Sbjct: 632 IGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQL 676
>gi|110825958 v-erb-a erythroblastic leukemia viral oncogene homolog
4 isoform JM-a/CVT-2 precursor [Homo sapiens]
Length = 1292
Score = 205 bits (521), Expect = 1e-52
Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%)
Query: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409
K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++
Sbjct: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780
Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468
VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V
Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+
Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899
Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959
Query: 589 DVENRPGF 596
D ++RP F
Sbjct: 960 DADSRPKF 967
>gi|4885215 v-erb-a erythroblastic leukemia viral oncogene homolog 4
isoform JM-a/CVT-1 precursor [Homo sapiens]
Length = 1308
Score = 205 bits (521), Expect = 1e-52
Identities = 107/248 (43%), Positives = 160/248 (64%), Gaps = 5/248 (2%)
Query: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409
K LGSG FGTV KG + + + V VA+KIL NE P E + EA +M +D+P++
Sbjct: 722 KVLGSGAFGTVYKGIWVPEGETVKIPVAIKIL-NETTGPKANVEFMDEALIMASMDHPHL 780
Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468
VR++G+C + + LV ++ G L +Y+ +++ ++ + ++ Q++ GM YLEE V
Sbjct: 781 VRLLGVCLSPTIQLVTQLMPHGCLLEYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLV 840
Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A ECI+Y KF+
Sbjct: 841 HRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADG-GKMPIKWMALECIHYRKFTH 899
Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 900 QSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMI 959
Query: 589 DVENRPGF 596
D ++RP F
Sbjct: 960 DADSRPKF 967
>gi|29725609 epidermal growth factor receptor isoform a precursor
[Homo sapiens]
Length = 1210
Score = 203 bits (517), Expect = 3e-52
Identities = 107/248 (43%), Positives = 161/248 (64%), Gaps = 5/248 (2%)
Query: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409
K LGSG FGTV KG + + +KV VA+K L+ EA P E+L EA VM +DNP++
Sbjct: 716 KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELR-EATSPKANKEILDEAYVMASVDNPHV 774
Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468
R++GIC + L+ ++ G L Y+++++ ++ + ++ Q++ GM YLE+ V
Sbjct: 775 CRLLGICLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLV 834
Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
HRDLAARNVL+ T + KI+DFGL+K L A+E Y A+ GK P+KW A E I + ++
Sbjct: 835 HRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEG-GKVPIKWMALESILHRIYTH 893
Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588
+SDVWS+GV +WE ++G KPY G+ SE++++LEKGER+ P C ++Y +M CW
Sbjct: 894 QSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMI 953
Query: 589 DVENRPGF 596
D ++RP F
Sbjct: 954 DADSRPKF 961
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 201 bits (510), Expect = 2e-51
Identities = 145/450 (32%), Positives = 219/450 (48%), Gaps = 80/450 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
E PWF +SR+++E+ +L T+G FLIR ++ GS++L +
Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV--------------- 167
Query: 223 TGKLSIPEGKKFD-TLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL--PGS 279
+ FD ++V+HY KI N F P++ PG
Sbjct: 168 ---------RDFDQNQGEVVKHY----------------KIRNLDNGGFYISPRITFPGL 202
Query: 280 HPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKE 339
H A+D R + P T+ + P+ + E P+E
Sbjct: 203 HELVRHYTN-------------------ASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRE 243
Query: 340 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 399
KL+ + LG+G FG V GYY VAVK LK + P D LAEAN
Sbjct: 244 TL---KLV----ERLGAGQFGEVWMGYYNGHT---KVAVKSLKQGSMSP---DAFLAEAN 290
Query: 400 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVK--DKNIIELVHQVSM 457
+M+QL + +VR+ + E ++ E E G L +L+ +K ++++ Q++
Sbjct: 291 LMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 350
Query: 458 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 517
GM ++EE N++HRDL A N+L+ KI+DFGL++ + ++N Y A+ K+P+KW A
Sbjct: 351 GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTA 408
Query: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577
PE INY F+ KSDVWSFG+L+ E ++G+ PY GM EV LE+G RM P CP E
Sbjct: 409 PEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEE 468
Query: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 607
+Y LM LCW E+RP F + L +++
Sbjct: 469 LYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 5/114 (4%)
Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA-----HGRKA 61
A+S P+FF N++R++AE L+ G + G +L+R+S + G F+LSV G
Sbjct: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178
Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQP 115
HY I NG + I+ T +L +++ SDGL L +P + +P
Sbjct: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 201 bits (510), Expect = 2e-51
Identities = 145/450 (32%), Positives = 219/450 (48%), Gaps = 80/450 (17%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDK 222
E PWF +SR+++E+ +L T+G FLIR ++ GS++L +
Sbjct: 123 EPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSV--------------- 167
Query: 223 TGKLSIPEGKKFD-TLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQL--PGS 279
+ FD ++V+HY KI N F P++ PG
Sbjct: 168 ---------RDFDQNQGEVVKHY----------------KIRNLDNGGFYISPRITFPGL 202
Query: 280 HPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKE 339
H A+D R + P T+ + P+ + E P+E
Sbjct: 203 HELVRHYTN-------------------ASDGLCTRLSRPCQTQKPQKPWWEDEWEVPRE 243
Query: 340 VYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEAN 399
KL+ + LG+G FG V GYY VAVK LK + P D LAEAN
Sbjct: 244 TL---KLV----ERLGAGQFGEVWMGYYNGHT---KVAVKSLKQGSMSP---DAFLAEAN 290
Query: 400 VMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVK--DKNIIELVHQVSM 457
+M+QL + +VR+ + E ++ E E G L +L+ +K ++++ Q++
Sbjct: 291 LMKQLQHQRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAE 350
Query: 458 GMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYA 517
GM ++EE N++HRDL A N+L+ KI+DFGL++ + ++N Y A+ K+P+KW A
Sbjct: 351 GMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLI--EDNEYTAREGAKFPIKWTA 408
Query: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577
PE INY F+ KSDVWSFG+L+ E ++G+ PY GM EV LE+G RM P CP E
Sbjct: 409 PEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEE 468
Query: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 607
+Y LM LCW E+RP F + L +++
Sbjct: 469 LYQLMRLCWKERPEDRPTFDYLRSVLEDFF 498
Score = 58.5 bits (140), Expect = 2e-08
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 5/114 (4%)
Query: 7 ADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVA-----HGRKA 61
A+S P+FF N++R++AE L+ G + G +L+R+S + G F+LSV G
Sbjct: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178
Query: 62 HHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQP 115
HY I NG + I+ T +L +++ SDGL L +P + +P
Sbjct: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTQKPQKP 232
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 200 bits (509), Expect = 3e-51
Identities = 144/454 (31%), Positives = 211/454 (46%), Gaps = 88/454 (19%)
Query: 164 EKMPWFHGKISREESEQIVLIGSKTNGKFLIR-ARDNNGSYALCLL-----HEGKVLHYR 217
E WF ISR+++E+ +L G F+IR + GSY+L + V HY+
Sbjct: 140 ETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVKHYK 199
Query: 218 IDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLP 277
I G I F TL +LV+HY DGL CQK+
Sbjct: 200 IRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGL-------CQKL--------------- 237
Query: 278 GSHPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRP 337
S P ++ + PW D +E P
Sbjct: 238 -----SVPCMSSKPQK------------PWEKD-------------AWEIP--------- 258
Query: 338 KEVYLDRKLLTLEDKELGSGNFGTVKKGYYQM--KKVVKTVAVKILKNEANDPALKDELL 395
R+ L LE K+LG+G FG V Y K VKT+ + EA L
Sbjct: 259 ------RESLKLE-KKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEA--------FL 303
Query: 396 AEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDK--NIIELVH 453
AEANVM+ L + +V++ + E ++ E G L +L+ + K +I+
Sbjct: 304 AEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSA 363
Query: 454 QVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPV 513
Q++ GM ++E+ N++HRDL A N+L+ KI+DFGL++ + ++N Y A+ K+P+
Sbjct: 364 QIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVI--EDNEYTAREGAKFPI 421
Query: 514 KWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAG 573
KW APE IN+ F+ KSDVWSFG+L+ E +YG+ PY GM EV LE+G RM P
Sbjct: 422 KWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPEN 481
Query: 574 CPREMYDLMNLCWTYDVENRPGFAAVELRLRNYY 607
CP E+Y++M CW E RP F ++ L ++Y
Sbjct: 482 CPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFY 515
Score = 47.8 bits (112), Expect = 3e-05
Identities = 48/191 (25%), Positives = 80/191 (41%), Gaps = 22/191 (11%)
Query: 8 DSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSV-----AHGRKAH 62
DS +FF I+R++AE L+ G G +++R S G ++LSV G
Sbjct: 137 DSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTVK 196
Query: 63 HYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP--FNRPQGVQPKTG-- 118
HY I NG + I+ T ++ +L ++ + +DGL L P ++PQ K
Sbjct: 197 HYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSSKPQKPWEKDAWE 256
Query: 119 -PFEDLK------ENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIA------TTAHEK 165
P E LK E T+N + + + +E +A T H+K
Sbjct: 257 IPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTLQHDK 316
Query: 166 MPWFHGKISRE 176
+ H +++E
Sbjct: 317 LVKLHAVVTKE 327
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 196 bits (499), Expect = 4e-50
Identities = 160/456 (35%), Positives = 218/456 (47%), Gaps = 87/456 (19%)
Query: 155 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKV 213
E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ +GK
Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCDGK- 125
Query: 214 LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR 273
VEHY + K+ V F
Sbjct: 126 ---------------------------VEHYR---------IMYHASKLSIDEEVYFENL 149
Query: 274 PQLPGSHPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPE 333
QL + +S A G T P E A D E Y S +A
Sbjct: 150 MQLVEHY--TSDADGL---CTRLIKPKVMEGTVAAQD------------EFYRSGWA--- 189
Query: 334 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 393
+ KE+ KLL + +G G FG V G Y+ KV AVK +KN+A A
Sbjct: 190 -LNMKEL----KLL----QTIGKGEFGDVMLGDYRGNKV----AVKCIKNDATAQAF--- 233
Query: 394 LLAEANVMQQLDNPYIVRMIGICEAESWML--VMEMAELGPLNKYLQ-QNRHVKDKN-II 449
LAEA+VM QL + +V+++G+ E L V E G L YL+ + R V + ++
Sbjct: 234 -LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292
Query: 450 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 509
+ V M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K + Q G
Sbjct: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS------TQDTG 346
Query: 510 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 569
K PVKW APE + KFS+KSDVWSFG+L+WE +S+G+ PY + +V +EKG +M
Sbjct: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406
Query: 570 CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 605
P GCP +Y++M CW D RP F + +L +
Sbjct: 407 APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH 442
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72
+P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I +
Sbjct: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS- 136
Query: 73 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106
+I + L +++ ++DGL L KP
Sbjct: 137 KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP 170
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 196 bits (499), Expect = 4e-50
Identities = 160/456 (35%), Positives = 218/456 (47%), Gaps = 87/456 (19%)
Query: 155 EKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKV 213
E + A T MPWFHGKI+RE++E+ L+ G FL+R N G Y LC+ +GK
Sbjct: 69 EGVKAGTKLSLMPWFHGKITREQAER--LLYPPETGLFLVRESTNYPGDYTLCVSCDGK- 125
Query: 214 LHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGR 273
VEHY + K+ V F
Sbjct: 126 ---------------------------VEHYR---------IMYHASKLSIDEEVYFENL 149
Query: 274 PQLPGSHPASSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPE 333
QL + +S A G T P E A D E Y S +A
Sbjct: 150 MQLVEHY--TSDADGL---CTRLIKPKVMEGTVAAQD------------EFYRSGWA--- 189
Query: 334 EIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDE 393
+ KE+ KLL + +G G FG V G Y+ KV AVK +KN+A A
Sbjct: 190 -LNMKEL----KLL----QTIGKGEFGDVMLGDYRGNKV----AVKCIKNDATAQAF--- 233
Query: 394 LLAEANVMQQLDNPYIVRMIGICEAESWML--VMEMAELGPLNKYLQ-QNRHVKDKN-II 449
LAEA+VM QL + +V+++G+ E L V E G L YL+ + R V + ++
Sbjct: 234 -LAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLL 292
Query: 450 ELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHG 509
+ V M+YLE +NFVHRDLAARNVL+ + AK+SDFGL+K + Q G
Sbjct: 293 KFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS------TQDTG 346
Query: 510 KWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMG 569
K PVKW APE + KFS+KSDVWSFG+L+WE +S+G+ PY + +V +EKG +M
Sbjct: 347 KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMD 406
Query: 570 CPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRN 605
P GCP +Y++M CW D RP F + +L +
Sbjct: 407 APDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEH 442
Score = 47.8 bits (112), Expect = 3e-05
Identities = 32/94 (34%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 13 LPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNG 72
+P+F G ITRE+AE L GL+L+R+S NY G + L V+ K HY I +
Sbjct: 80 MPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYHAS- 136
Query: 73 TYAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106
+I + L +++ ++DGL L KP
Sbjct: 137 KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP 170
>gi|27886590 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 196 bits (498), Expect = 5e-50
Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%)
Query: 354 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412
LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++
Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489
Query: 413 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 471
IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD
Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
Query: 472 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 531
+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD
Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607
Query: 532 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 591
VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 592 NRPGFAAVELRLRNYY 607
+RP F + L + Y
Sbjct: 668 DRPRFTELVCSLSDVY 683
>gi|27886588 PTK2B protein tyrosine kinase 2 beta isoform b [Homo
sapiens]
Length = 967
Score = 196 bits (498), Expect = 5e-50
Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%)
Query: 354 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412
LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++
Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489
Query: 413 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 471
IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD
Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
Query: 472 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 531
+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD
Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607
Query: 532 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 591
VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 592 NRPGFAAVELRLRNYY 607
+RP F + L + Y
Sbjct: 668 DRPRFTELVCSLSDVY 683
>gi|27886586 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 196 bits (498), Expect = 5e-50
Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%)
Query: 354 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412
LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++
Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489
Query: 413 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 471
IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD
Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
Query: 472 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 531
+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD
Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607
Query: 532 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 591
VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 592 NRPGFAAVELRLRNYY 607
+RP F + L + Y
Sbjct: 668 DRPRFTELVCSLSDVY 683
>gi|27886584 PTK2B protein tyrosine kinase 2 beta isoform a [Homo
sapiens]
Length = 1009
Score = 196 bits (498), Expect = 5e-50
Identities = 104/256 (40%), Positives = 156/256 (60%), Gaps = 5/256 (1%)
Query: 354 LGSGNFGTVKKGYYQMKKVVK-TVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRM 412
LG G FG V +G Y K K VAVK K + K++ ++EA +M+ LD+P+IV++
Sbjct: 431 LGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDN-KEKFMSEAVIMKNLDHPHIVKL 489
Query: 413 IGICEAESWMLVMEMAELGPLNKYLQQNRH-VKDKNIIELVHQVSMGMKYLEESNFVHRD 471
IGI E E ++ME+ G L YL++N++ +K ++ Q+ M YLE N VHRD
Sbjct: 490 IGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRD 549
Query: 472 LAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSD 531
+A RN+L+ + K+ DFGLS+ + DE+YYKA + P+KW +PE IN+ +F++ SD
Sbjct: 550 IAVRNILVASPECVKLGDFGLSRYIE-DEDYYKASVT-RLPIKWMSPESINFRRFTTASD 607
Query: 532 VWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVE 591
VW F V MWE S+G++P+ ++ +V +LEKG+R+ P CP +Y LM CW YD
Sbjct: 608 VWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPS 667
Query: 592 NRPGFAAVELRLRNYY 607
+RP F + L + Y
Sbjct: 668 DRPRFTELVCSLSDVY 683
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 195 bits (496), Expect = 9e-50
Identities = 106/270 (39%), Positives = 164/270 (60%), Gaps = 11/270 (4%)
Query: 342 LDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVM 401
+DR + L K LGSG FG V +G + VAVK LK + DP ++ L EA +M
Sbjct: 229 IDRNSIQLL-KRLGSGQFGEVWEGLWNN---TTPVAVKTLKPGSMDP---NDFLREAQIM 281
Query: 402 QQLDNPYIVRMIGICEAESWM-LVMEMAELGPLNKYLQQNRHVKDK--NIIELVHQVSMG 458
+ L +P ++++ +C E + ++ E+ G L +YLQ + K +++ QV+ G
Sbjct: 282 KNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASG 341
Query: 459 MKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRAD-ENYYKAQTHGKWPVKWYA 517
M YLE N++HRDLAARNVL+ + K++DFGL++ + D E+ Y+++ K PVKW A
Sbjct: 342 MAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTA 401
Query: 518 PECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPRE 577
PE I KFS KSDVWSFG+L++E +YG+ PY GM G++V ML + R+ P+ CP++
Sbjct: 402 PEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQ 461
Query: 578 MYDLMNLCWTYDVENRPGFAAVELRLRNYY 607
Y++M CW + + RP F + +L +Y+
Sbjct: 462 FYNIMLECWNAEPKERPTFETLRWKLEDYF 491
Score = 65.5 bits (158), Expect = 1e-10
Identities = 36/97 (37%), Positives = 51/97 (52%), Gaps = 1/97 (1%)
Query: 167 PWFHGKISREESEQIVLIGSKTNGKFLIRARDNN-GSYALCLLHEGKVLHYRIDKDKTGK 225
PWF G I R ++E+ +L G FLIR ++ G ++L +L V HYRI + G
Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174
Query: 226 LSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKI 262
+ + F TL + V HY+ +DGL L PC KI
Sbjct: 175 FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKI 211
Score = 58.2 bits (139), Expect = 2e-08
Identities = 32/93 (34%), Positives = 50/93 (53%)
Query: 14 PFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGT 73
P+FFG I R +AE L+ G +L+R+S + G F+LSV G HY I+R G
Sbjct: 115 PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGG 174
Query: 74 YAIAGGRTHASPADLCHYHSQESDGLVCLLKKP 106
+ + R ++ + ++++ SDGL L KP
Sbjct: 175 FFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKP 207
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 192 bits (488), Expect = 8e-49
Identities = 112/305 (36%), Positives = 176/305 (57%), Gaps = 10/305 (3%)
Query: 300 YEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNF 359
Y +L ++ +G + +D YE P E +R +D + +E+ +G+G F
Sbjct: 575 YSDKLQHYSTGRGSPGMKIYIDPFTYEDPN---EAVREFAKEIDVSFVKIEEV-IGAGEF 630
Query: 360 GTVKKGYYQMK-KVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGIC-E 417
G V KG ++ K VA+K LK ++ +D L+EA++M Q D+P I+R+ G+ +
Sbjct: 631 GEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRD-FLSEASIMGQFDHPNIIRLEGVVTK 689
Query: 418 AESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARN 476
+ M++ E E G L+ +L+QN ++ ++ ++ GMKYL E N+VHRDLAARN
Sbjct: 690 SRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARN 749
Query: 477 VLLVTQHYAKISDFGLSKALRADEN--YYKAQTHGKWPVKWYAPECINYYKFSSKSDVWS 534
+L+ + K+SDFGLS+ L+ D + Y + GK PV+W APE I Y KF+S SDVWS
Sbjct: 750 ILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWS 809
Query: 535 FGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRP 594
+G++MWE S+G++PY M +V +E+ R+ P CP ++ LM CW D +RP
Sbjct: 810 YGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRP 869
Query: 595 GFAAV 599
FA +
Sbjct: 870 RFAEI 874
>gi|56549666 tyrosine kinase, non-receptor, 2 isoform 1 [Homo
sapiens]
Length = 1038
Score = 191 bits (486), Expect = 1e-48
Identities = 100/252 (39%), Positives = 151/252 (59%), Gaps = 4/252 (1%)
Query: 352 KELGSGNFGTVKKGYYQMKK-VVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYI 409
++LG G+FG V++G + +VAVK LK + + P D+ + E N M LD+ +
Sbjct: 130 EKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNL 189
Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468
+R+ G+ +V E+A LG L L++++ H + QV+ GM YLE F+
Sbjct: 190 IRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFI 249
Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W APE + FS
Sbjct: 250 HRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSH 309
Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCWT 587
SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP+++Y++M CW
Sbjct: 310 ASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWA 369
Query: 588 YDVENRPGFAAV 599
+ E+RP F A+
Sbjct: 370 HKPEDRPTFVAL 381
>gi|58331191 tyrosine kinase, non-receptor, 2 isoform 2 [Homo
sapiens]
Length = 1086
Score = 191 bits (486), Expect = 1e-48
Identities = 100/252 (39%), Positives = 151/252 (59%), Gaps = 4/252 (1%)
Query: 352 KELGSGNFGTVKKGYYQMKK-VVKTVAVKILKNEA-NDPALKDELLAEANVMQQLDNPYI 409
++LG G+FG V++G + +VAVK LK + + P D+ + E N M LD+ +
Sbjct: 193 EKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNL 252
Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468
+R+ G+ +V E+A LG L L++++ H + QV+ GM YLE F+
Sbjct: 253 IRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFI 312
Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
HRDLAARN+LL T+ KI DFGL +AL ++++Y Q H K P W APE + FS
Sbjct: 313 HRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSH 372
Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEK-GERMGCPAGCPREMYDLMNLCWT 587
SD W FGV +WE F+YGQ+P+ G+ GS++ ++K GER+ P CP+++Y++M CW
Sbjct: 373 ASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWA 432
Query: 588 YDVENRPGFAAV 599
+ E+RP F A+
Sbjct: 433 HKPEDRPTFVAL 444
>gi|54792098 erbB-2 isoform b [Homo sapiens]
Length = 1225
Score = 191 bits (485), Expect = 2e-48
Identities = 105/248 (42%), Positives = 153/248 (61%), Gaps = 5/248 (2%)
Query: 352 KELGSGNFGTVKKGYY--QMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYI 409
K LGSG FGTV KG + + V VA+K+L+ E P E+L EA VM + +PY+
Sbjct: 694 KVLGSGAFGTVYKGIWIPDGENVKIPVAIKVLR-ENTSPKANKEILDEAYVMAGVGSPYV 752
Query: 410 VRMIGICEAESWMLVMEMAELGPLNKYLQQNR-HVKDKNIIELVHQVSMGMKYLEESNFV 468
R++GIC + LV ++ G L ++++NR + ++++ Q++ GM YLE+ V
Sbjct: 753 SRLLGICLTSTVQLVTQLMPYGCLLDHVRENRGRLGSQDLLNWCMQIAKGMSYLEDVRLV 812
Query: 469 HRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSS 528
HRDLAARNVL+ + ++ KI+DFGL++ L DE Y A GK P+KW A E I +F+
Sbjct: 813 HRDLAARNVLVKSPNHVKITDFGLARLLDIDETEYHADG-GKVPIKWMALESILRRRFTH 871
Query: 529 KSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTY 588
+SDVWS+GV +WE ++G KPY G+ E+ +LEKGER+ P C ++Y +M CW
Sbjct: 872 QSDVWSYGVTVWELMTFGAKPYDGIPAREIPDLLEKGERLPQPPICTIDVYMIMVKCWMI 931
Query: 589 DVENRPGF 596
D E RP F
Sbjct: 932 DSECRPRF 939
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,249,107
Number of Sequences: 37866
Number of extensions: 1161749
Number of successful extensions: 4901
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 649
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 3018
Number of HSP's gapped (non-prelim): 1137
length of query: 612
length of database: 18,247,518
effective HSP length: 108
effective length of query: 504
effective length of database: 14,157,990
effective search space: 7135626960
effective search space used: 7135626960
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.