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Search of human proteins with 205277383
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|205277383 macrophage stimulating 1 (hepatocyte growth
factor-like) [Homo sapiens]
(725 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|205277383 macrophage stimulating 1 (hepatocyte growth factor-... 1596 0.0
gi|33859835 hepatocyte growth factor isoform 1 preproprotein [Ho... 631 0.0
gi|58533170 hepatocyte growth factor isoform 3 precursor [Homo s... 627 e-180
gi|4505881 plasminogen [Homo sapiens] 487 e-137
gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens] 465 e-131
gi|58533163 hepatocyte growth factor isoform 2 precursor [Homo s... 242 8e-64
gi|58533165 hepatocyte growth factor isoform 4 precursor [Homo s... 238 1e-62
gi|4503635 coagulation factor II preproprotein [Homo sapiens] 175 2e-43
gi|4505861 plasminogen activator, tissue isoform 1 preproprotein... 174 3e-43
gi|14702169 plasminogen activator, tissue isoform 3 preproprotei... 174 3e-43
gi|4504383 HGF activator preproprotein [Homo sapiens] 156 7e-38
gi|222537759 plasminogen activator, urokinase isoform 2 [Homo sa... 144 2e-34
gi|4505863 plasminogen activator, urokinase isoform 1 preproprot... 144 2e-34
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 134 3e-31
gi|118498350 chymotrypsin B2 [Homo sapiens] 132 1e-30
gi|118498341 chymotrypsin B1 [Homo sapiens] 130 6e-30
gi|58533167 hepatocyte growth factor isoform 5 precursor [Homo s... 128 2e-29
gi|117956391 protease, serine, 33 [Homo sapiens] 126 8e-29
gi|4503137 chymotrypsin-like [Homo sapiens] 124 2e-28
gi|68508970 tryptase beta 2 precursor [Homo sapiens] 124 3e-28
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 124 4e-28
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 124 4e-28
gi|156938340 transmembrane tryptase preproprotein [Homo sapiens] 122 1e-27
gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens] 121 3e-27
gi|13994276 marapsin [Homo sapiens] 118 2e-26
gi|33695155 hepsin [Homo sapiens] 117 3e-26
gi|4504481 hepsin [Homo sapiens] 117 3e-26
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 117 3e-26
gi|15559207 elastase 2A preproprotein [Homo sapiens] 117 5e-26
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 116 6e-26
>gi|205277383 macrophage stimulating 1 (hepatocyte growth
factor-like) [Homo sapiens]
Length = 725
Score = 1596 bits (4132), Expect = 0.0
Identities = 725/725 (100%), Positives = 725/725 (100%)
Query: 1 MGLWWVTVQPPARRMGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPW 60
MGLWWVTVQPPARRMGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPW
Sbjct: 1 MGLWWVTVQPPARRMGWLPLLLLLTQCLGVPGQRSPLNDFQVLRGTELQHLLHAVVPGPW 60
Query: 61 QEDVADAEECAGRCGPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDY 120
QEDVADAEECAGRCGPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDY
Sbjct: 61 QEDVADAEECAGRCGPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLFQKKDY 120
Query: 121 VRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGG 180
VRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGG
Sbjct: 121 VRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPDGDPGG 180
Query: 181 PWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFE 240
PWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFE
Sbjct: 181 PWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFE 240
Query: 241 PGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRG 300
PGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRG
Sbjct: 241 PGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRG 300
Query: 301 KGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTL 360
KGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTL
Sbjct: 301 KGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTL 360
Query: 361 RPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTF 420
RPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTF
Sbjct: 361 RPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTF 420
Query: 421 TSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFE 480
TSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFE
Sbjct: 421 TSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFE 480
Query: 481 KCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSS 540
KCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSS
Sbjct: 481 KCGKRVDRLDQRRSKLRVVGGHPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSS 540
Query: 541 CHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVAL 600
CHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVAL
Sbjct: 541 CHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVAL 600
Query: 601 ICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMC 660
ICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMC
Sbjct: 601 ICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHRGRVRESEMC 660
Query: 661 TEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHK 720
TEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHK
Sbjct: 661 TEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHK 720
Query: 721 VMRLG 725
VMRLG
Sbjct: 721 VMRLG 725
>gi|33859835 hepatocyte growth factor isoform 1 preproprotein [Homo
sapiens]
Length = 728
Score = 631 bits (1628), Expect = 0.0
Identities = 318/735 (43%), Positives = 424/735 (57%), Gaps = 33/735 (4%)
Query: 5 WVTVQPPARRMGWLPLLLLLTQCL-----GVPGQRSPLNDFQVLRGTELQHLLHAVVPGP 59
WVT PA + + L LLL G +R+ +++F+ T L + A+
Sbjct: 2 WVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKT 61
Query: 60 WQEDVADAEECAGRC----GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLF 115
+ + AD +CA RC G C+AF ++ + C P+ S + DL+
Sbjct: 62 KKVNTAD--QCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLY 119
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNG--LEENFCRN 173
+ KDY+R CI+ G Y+GT++ T G+ CQ WS P++H + P+ G L+EN+CRN
Sbjct: 120 ENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRN 179
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQH 233
P G+ GGPWC+T++P VR++ C I C E C+ CNGE YRG +D TESG+ CQRWD Q
Sbjct: 180 PRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQT 239
Query: 234 PHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEA- 292
PH+H F P ++ D+G DDNYCRNPDG RPWCYT DP E+C + C +
Sbjct: 240 PHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVP 299
Query: 293 -TTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDG 351
T C +G+GEGYRGT NT G+PCQRWD+Q PH+H TPE + CKDLREN+CRNPDG
Sbjct: 300 LETTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDG 359
Query: 352 SEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAE 411
SE+PWCFT P +R +C QI C D QDCY G G+ Y G +S+TR G+ C W
Sbjct: 360 SESPWCFTTDPNIRVGYCSQIPNC-DMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKN 418
Query: 412 TPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSIL 471
+ F ++L EN+CRNPD D+HGPWCYT +P P+DYC + RC D P+I+
Sbjct: 419 MEDLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIV 478
Query: 472 DPPDQVQFEKCGKRVDRLDQRRSKLRVVGGHP--GNSPWTVSLRNRQGQHFCGGSLVKEQ 529
+ V C K +LRVV G P N W VSLR R +H CGGSL+KE
Sbjct: 479 NLDHPV--ISCAK--------TKQLRVVNGIPTRTNIGWMVSLRYR-NKHICGGSLIKES 527
Query: 530 WILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLE 589
W+LTARQCF S L YE WLG + + E Q + V+++V GP GS LVL+KL
Sbjct: 528 WVLTARQCFPS--RDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLA 585
Query: 590 RSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIK 649
R L+ V+ I LP +P T C + GWG T D +L VA L ++ N++C+
Sbjct: 586 RPAVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQH 645
Query: 650 HRGRV--RESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAV 707
HRG+V ESE+C G CEGDYGGPL C H ++ G+I+P R CA P +
Sbjct: 646 HRGKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGI 705
Query: 708 FTRVSVFVDWIHKVM 722
F RV+ + WIHK++
Sbjct: 706 FVRVAYYAKWIHKII 720
>gi|58533170 hepatocyte growth factor isoform 3 precursor [Homo
sapiens]
Length = 723
Score = 627 bits (1618), Expect = e-180
Identities = 317/733 (43%), Positives = 421/733 (57%), Gaps = 34/733 (4%)
Query: 5 WVTVQPPARRMGWLPLLLLLTQCL-----GVPGQRSPLNDFQVLRGTELQHLLHAVVPGP 59
WVT PA + + L LLL G +R+ +++F+ T L + A+
Sbjct: 2 WVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKT 61
Query: 60 WQEDVADAEECAGRC----GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLF 115
+ + AD +CA RC G C+AF ++ + C P+ S + DL+
Sbjct: 62 KKVNTAD--QCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLY 119
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPD 175
+ KDY+R CI+ G Y+GT++ T G+ CQ WS P++H Y L+EN+CRNP
Sbjct: 120 ENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSYRG---KDLQENYCRNPR 176
Query: 176 GDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPH 235
G+ GGPWC+T++P VR++ C I C E C+ CNGE YRG +D TESG+ CQRWD Q PH
Sbjct: 177 GEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPH 236
Query: 236 QHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRCGSEAQPRQEA--T 293
+H F P ++ D+G DDNYCRNPDG RPWCYT DP E+C + C +
Sbjct: 237 RHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTCADNTMNDTDVPLE 296
Query: 294 TVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSE 353
T C +G+GEGYRGT NT G+PCQRWD+Q PH+H TPE + CKDLREN+CRNPDGSE
Sbjct: 297 TTECIQGQGEGYRGTVNTIWNGIPCQRWDSQYPHEHDMTPENFKCKDLRENYCRNPDGSE 356
Query: 354 APWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETP 413
+PWCFT P +R +C QI C D QDCY G G+ Y G +S+TR G+ C W
Sbjct: 357 SPWCFTTDPNIRVGYCSQIPNC-DMSHGQDCYRGNGKNYMGNLSQTRSGLTCSMWDKNME 415
Query: 414 HKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDP 473
+ F ++L EN+CRNPD D+HGPWCYT +P P+DYC + RC D P+I++
Sbjct: 416 DLHRHIFWEPDASKLNENYCRNPDDDAHGPWCYTGNPLIPWDYCPISRCEGDTTPTIVNL 475
Query: 474 PDQVQFEKCGKRVDRLDQRRSKLRVVGGHP--GNSPWTVSLRNRQGQHFCGGSLVKEQWI 531
V C K +LRVV G P N W VSLR R +H CGGSL+KE W+
Sbjct: 476 DHPV--ISCAK--------TKQLRVVNGIPTRTNIGWMVSLRYR-NKHICGGSLIKESWV 524
Query: 532 LTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERS 591
LTARQCF S L YE WLG + + E Q + V+++V GP GS LVL+KL R
Sbjct: 525 LTARQCFPS--RDLKDYEAWLGIHDVHGRGDEKCKQVLNVSQLVYGPEGSDLVLMKLARP 582
Query: 592 VTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKHR 651
L+ V+ I LP +P T C + GWG T D +L VA L ++ N++C+ HR
Sbjct: 583 AVLDDFVSTIDLPNYGCTIPEKTSCSVYGWGYTGLINYDGLLRVAHLYIMGNEKCSQHHR 642
Query: 652 GRV--RESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFT 709
G+V ESE+C G CEGDYGGPL C H ++ G+I+P R CA P +F
Sbjct: 643 GKVTLNESEICAGAEKIGSGPCEGDYGGPLVCEQHKMRMVLGVIVPGRGCAIPNRPGIFV 702
Query: 710 RVSVFVDWIHKVM 722
RV+ + WIHK++
Sbjct: 703 RVAYYAKWIHKII 715
>gi|4505881 plasminogen [Homo sapiens]
Length = 810
Score = 487 bits (1253), Expect = e-137
Identities = 261/661 (39%), Positives = 354/661 (53%), Gaps = 67/661 (10%)
Query: 107 RRSGRCDLFQKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTL--RN 164
+R CD+ + ++ C+ +G Y G ++ T+ GL CQAW + P+ H Y P+
Sbjct: 171 KRYDYCDILECEE---ECMHCSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNK 227
Query: 165 GLEENFCRNPDGDPGGPWCYTTDPAVRFQSCGIKSCREAA--------CVWCNGEEYRGA 216
L++N+CRNPD + PWC+TTDP R++ C I C C+ GE YRG
Sbjct: 228 NLKKNYCRNPDRELR-PWCFTTDPNKRWELCDIPRCTTPPPSSGPTYQCLKGTGENYRGN 286
Query: 217 VDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREF 276
V T SG CQ W Q PH H P F + LD+NYCRNPDG PWC+TT+ Q+ E+
Sbjct: 287 VAVTVSGHTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEY 346
Query: 277 CDLPRCGSE----------AQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIP 326
C +P C S A P C+ G G+ YRGT++TTT G CQ W + P
Sbjct: 347 CKIPSCDSSPVSTEQLAPTAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTP 406
Query: 327 HQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRCTDD----VRP- 381
H+H+ TPE Y L N+CRNPD + PWCFT P +R +C +++C+ V P
Sbjct: 407 HRHQKTPENYPNAGLTMNYCRNPDADKGPWCFTTDPSVRWEYC-NLKKCSGTEASVVAPP 465
Query: 382 -------------QDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQ-FTFTSEPHAQ 427
+DC G G+ YRG + T G CQ W+A+ PH+ FT + P A
Sbjct: 466 PVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTPCQDWAAQEPHRHSIFTPETNPRAG 525
Query: 428 LEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPPDQVQFEKCGKRVD 487
LE+N+CRNPDGD GPWCYT +PR +DYC + +CA PS CGK
Sbjct: 526 LEKNYCRNPDGDVGGPWCYTTNPRKLYDYCDVPQCA---APSF----------DCGK--P 570
Query: 488 RLDQRRSKLRVVGG---HPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMP 544
+++ ++ RVVGG HP + PW VSLR R G HFCGG+L+ +W+LTA C P
Sbjct: 571 QVEPKKCPGRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRP 630
Query: 545 LTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLP 604
+ Y+V LG + EP +Q + V+++ P+ + LLKL + +V CLP
Sbjct: 631 -SSYKVILGA--HQEVNLEPHVQEIEVSRLFLEPTRKDIALLKLSSPAVITDKVIPACLP 687
Query: 605 PEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVISNQECNIKH--RGRVRESEMCTE 662
YVV T+C I GWGET+GT +L A L VI N+ CN GRV+ +E+C
Sbjct: 688 SPNYVVADRTECFITGWGETQGTFGAGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAG 747
Query: 663 GLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVM 722
L +C+GD GGPL CF + ++L+G+ CAR P V+ RVS FV WI VM
Sbjct: 748 HLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVM 807
Query: 723 R 723
R
Sbjct: 808 R 808
Score = 406 bits (1043), Expect = e-113
Identities = 201/463 (43%), Positives = 256/463 (55%), Gaps = 33/463 (7%)
Query: 32 GQRSPLNDFQVLRGTELQHLLHAVVPGPWQEDVADAEECAGRC--GPLMDCRAFHYNVSS 89
GQ PL+D+ +G L + Q EECA +C CRAF Y+
Sbjct: 17 GQGEPLDDYVNTQGASLFSVTKK------QLGAGSIEECAAKCEEDEEFTCRAFQYHSKE 70
Query: 90 HGCQLLPWTQHSPHTRLRRSGRCDLFQKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWS 149
C ++ + S + + R LF+KK Y+ C NG YRGTM+ T G+ CQ WS
Sbjct: 71 QQCVIMAENRKS--SIIIRMRDVVLFEKKVYLSECKTGNGKNYRGTMSKTKNGITCQKWS 128
Query: 150 HKFPNDHKYTPTLR--NGLEENFCRNPDGDPGGPWCYTTDPAVRFQSCGIKSCREAACVW 207
P+ +++P GLEEN+CRNPD DP GPWCYTTDP R+ C I C E C+
Sbjct: 129 STSPHRPRFSPATHPSEGLEENYCRNPDNDPQGPWCYTTDPEKRYDYCDILECEEE-CMH 187
Query: 208 CNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYT 267
C+GE Y G + +T SG ECQ WD Q PH H + P KF ++ L NYCRNPD RPWC+T
Sbjct: 188 CSGENYDGKISKTMSGLECQAWDSQSPHAHGYIPSKFPNKNLKKNYCRNPDRELRPWCFT 247
Query: 268 TDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPH 327
TDP E CD+PRC P T C +G GE YRG T +G CQ W AQ PH
Sbjct: 248 TDPNKRWELCDIPRC--TTPPPSSGPTYQCLKGTGENYRGNVAVTVSGHTCQHWSAQTPH 305
Query: 328 QHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRC------TDDVRP 381
H TPE + CK+L EN+CRNPDG APWC T +R +C +I C T+ + P
Sbjct: 306 THNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYC-KIPSCDSSPVSTEQLAP 364
Query: 382 ----------QDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEEN 431
QDCYHG G+ YRGT S T G +CQ WS+ TPH+ Q T + P+A L N
Sbjct: 365 TAPPELTPVVQDCYHGDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPENYPNAGLTMN 424
Query: 432 FCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDPP 474
+CRNPD D GPWC+T DP ++YC L++C+ + + PP
Sbjct: 425 YCRNPDADK-GPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPP 466
>gi|116292750 lipoprotein Lp(a) precursor [Homo sapiens]
Length = 2040
Score = 465 bits (1196), Expect = e-131
Identities = 257/681 (37%), Positives = 347/681 (50%), Gaps = 105/681 (15%)
Query: 121 VRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTL--RNGLEENFCRNPDGDP 178
V+ C +G YRGT++TT+ G CQ+WS P+ H+ P GL N+CRNPD +
Sbjct: 1385 VQDCYRGDGQSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEI 1444
Query: 179 GGPWCYTTDPAVRFQSCGIKSC----------------------REAA----------CV 206
PWCYT DP+VR++ C + C E A C
Sbjct: 1445 R-PWCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCY 1503
Query: 207 WCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCY 266
+G YRG T +GR CQ W PH H P + + GL +NYCRNPD ++PWCY
Sbjct: 1504 HGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQPWCY 1563
Query: 267 TTDPQIEREFCDLPRCG---------------------SEAQPRQEATTV-SCFRGKGEG 304
TTDP + E+C+L +C SEA P ++ V C+ G G+
Sbjct: 1564 TTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQCYHGNGQS 1623
Query: 305 YRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGM 364
YRGT +TT G CQ W + PH+H+ TPE Y L N+CRNPD PWCFT+ P +
Sbjct: 1624 YRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSI 1683
Query: 365 RAAFCYQIRRCTDD----VRP--------------QDCYHGAGEQYRGTVSKTRKGVQCQ 406
R +C + RC+D V P QDC G G+ YRG + T G CQ
Sbjct: 1684 RWEYC-NLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTPCQ 1742
Query: 407 RWSAETPHK-PQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCADD 465
W+A+ PH+ F + A LE+N+CRNPDGD +GPWCYTM+PR FDYC + CA
Sbjct: 1743 EWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCAS- 1801
Query: 466 QPPSILDPPDQVQFEKCGKRVDRLDQRRSKLRVVGG---HPGNSPWTVSLRNRQGQHFCG 522
S D CGK +++ ++ +VGG HP + PW VSLR R G+HFCG
Sbjct: 1802 ---SSFD---------CGK--PQVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCG 1847
Query: 523 GSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQ 582
G+L+ +W+LTA C P + Y+V LG + E +Q + V+++ P+ +
Sbjct: 1848 GTLISPEWVLTAAHCLKKSSRP-SSYKVILGA--HQEVNLESHVQEIEVSRLFLEPTQAD 1904
Query: 583 LVLLKLERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDTVLNVALLNVIS 642
+ LLKL R + +V CLP Y+V T+C I GWGET+GT +L A L VI
Sbjct: 1905 IALLKLSRPAVITDKVMPACLPSPDYMVTARTECYITGWGETQGTFGTGLLKEAQLLVIE 1964
Query: 643 NQECNIKHRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARS 702
N+ CN +C E L +C+GD GGPL CF + ++L+G+ CAR
Sbjct: 1965 NEVCN-------HYKYICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARP 2017
Query: 703 RWPAVFTRVSVFVDWIHKVMR 723
P V+ RVS FV WI +MR
Sbjct: 2018 NKPGVYARVSRFVTWIEGMMR 2038
Score = 302 bits (773), Expect = 8e-82
Identities = 157/423 (37%), Positives = 206/423 (48%), Gaps = 79/423 (18%)
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTL--RNGLEENFCRN 173
+++ V+ C NG Y+GT TV G CQAWS P+ H TP GL +N+CRN
Sbjct: 932 EQRPGVQECYHGNGQSYQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIKNYCRN 991
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCREAA----------------------------- 204
PD PWCYTTDP+VR++ C + C +A
Sbjct: 992 PD-PVAAPWCYTTDPSVRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAFFEQALTEETPG 1050
Query: 205 ---CVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSE 261
C + G+ YRG T +GR CQ W PHQH P + + GL NYCRNPD
Sbjct: 1051 VQDCYYHYGQSYRGTYSTTVTGRTCQAWSSMTPHQHSRTPENYPNAGLTRNYCRNPDAEI 1110
Query: 262 RPWCYTTDPQIEREFCDLPRC---------------------GSEAQPRQEATTV-SCFR 299
RPWCYT DP + E+C+L +C SE P +++ V C+
Sbjct: 1111 RPWCYTMDPSVRWEYCNLTQCLVTESSVLATLTVVPDPSTEASSEEAPTEQSPGVQDCYH 1170
Query: 300 GKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFT 359
G G+ YRG+ +TT G CQ W + PH H+ T E Y L N+CRNPD +PWC+T
Sbjct: 1171 GDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEISPWCYT 1230
Query: 360 LRPGMRAAFCYQIRRC-------------TDDVRP-------QDCYHGAGEQYRGTVSKT 399
+ P +R +C + +C + P QDCYHG G+ YRG+ S T
Sbjct: 1231 MDPNVRWEYC-NLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYRGSFSTT 1289
Query: 400 RKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCAL 459
G CQ WS+ TPH Q T P+ L N+CRNPD + PWCYTMDP ++YC L
Sbjct: 1290 VTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEIR-PWCYTMDPSVRWEYCNL 1348
Query: 460 RRC 462
+C
Sbjct: 1349 TQC 1351
Score = 293 bits (749), Expect = 5e-79
Identities = 162/433 (37%), Positives = 208/433 (48%), Gaps = 80/433 (18%)
Query: 121 VRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTL--RNGLEENFCRNPDGDP 178
V+ C +G YRG+ +TTV G CQ+WS P+ H+ T GL N+CRNPD +
Sbjct: 1165 VQDCYHGDGQSYRGSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEI 1224
Query: 179 GGPWCYTTDPAVRFQSCGIKSC--------------REAA----------CVWCNGEEYR 214
PWCYT DP VR++ C + C E A C +G+ YR
Sbjct: 1225 S-PWCYTMDPNVRWEYCNLTQCPVTESSVLATSTAVSEQAPTEQSPTVQDCYHGDGQSYR 1283
Query: 215 GAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIER 274
G+ T +GR CQ W PH H + + GL NYCRNPD RPWCYT DP +
Sbjct: 1284 GSFSTTVTGRTCQSWSSMTPHWHQRTTEYYPNGGLTRNYCRNPDAEIRPWCYTMDPSVRW 1343
Query: 275 EFCDLPRC---------------------GSEAQPRQEATTV-SCFRGKGEGYRGTANTT 312
E+C+L +C SE P + +T V C+RG G+ YRGT +TT
Sbjct: 1344 EYCNLTQCPVMESTLLTTPTVVPVPSTELPSEEAPTENSTGVQDCYRGDGQSYRGTLSTT 1403
Query: 313 TAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQI 372
G CQ W + PH HR P Y L N+CRNPD PWC+T+ P +R +C +
Sbjct: 1404 ITGRTCQSWSSMTPHWHRRIPLYYPNAGLTRNYCRNPDAEIRPWCYTMDPSVRWEYC-NL 1462
Query: 373 RRC---------TDDVRP-------------------QDCYHGAGEQYRGTVSKTRKGVQ 404
RC T V P QDCYHG G YRG S T G
Sbjct: 1463 TRCPVTESSVLTTPTVAPVPSTEAPSEQAPPEKSPVVQDCYHGDGRSYRGISSTTVTGRT 1522
Query: 405 CQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRCAD 464
CQ WS+ PH Q T + P+A L EN+CRNPD PWCYT DP ++YC L +C++
Sbjct: 1523 CQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSGKQ-PWCYTTDPCVRWEYCNLTQCSE 1581
Query: 465 DQPPSILDPPDQV 477
+ +L+ P V
Sbjct: 1582 TE-SGVLETPTVV 1593
Score = 291 bits (745), Expect = 1e-78
Identities = 160/442 (36%), Positives = 210/442 (47%), Gaps = 87/442 (19%)
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTL--RNGLEENFCRN 173
+++ V+ C NG YRGT +TTV G CQAWS P+ H TP GL N+CRN
Sbjct: 134 EQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRN 193
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCREAA----------------------------- 204
PD P+CYT DP VR++ C + C +A
Sbjct: 194 PDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPG 252
Query: 205 ---CVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSE 261
C NG+ YRG T +GR CQ W PH H P + + GL NYCRNPD
Sbjct: 253 VQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA 312
Query: 262 RPWCYTTDPQIEREFCDLPRCG---------------------SEAQPRQEATTVS-CFR 299
P+CYT DP + E+C+L +C SE P ++ V C+
Sbjct: 313 APYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYH 372
Query: 300 GKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFT 359
G G+ YRGT +TT G CQ W + PH H TPE Y L N+CRNPD AP+C+T
Sbjct: 373 GNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYT 432
Query: 360 LRPGMRAAFCYQIRRCTD--------------------------DVRP--QDCYHGAGEQ 391
PG+R +C + +C+D + RP Q+CYHG G+
Sbjct: 433 RDPGVRWEYC-NLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQS 491
Query: 392 YRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPR 451
YRGT S T G CQ WS+ TPH T P+A L N+CRNPD + P+CYT DP
Sbjct: 492 YRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA-APYCYTRDPG 550
Query: 452 TPFDYCALRRCADDQPPSILDP 473
++YC L +C+D + ++ P
Sbjct: 551 VRWEYCNLTQCSDAEGTAVAPP 572
Score = 291 bits (745), Expect = 1e-78
Identities = 160/442 (36%), Positives = 210/442 (47%), Gaps = 87/442 (19%)
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTL--RNGLEENFCRN 173
+++ V+ C NG YRGT +TTV G CQAWS P+ H TP GL N+CRN
Sbjct: 362 EQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRN 421
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCREAA----------------------------- 204
PD P+CYT DP VR++ C + C +A
Sbjct: 422 PDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPG 480
Query: 205 ---CVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSE 261
C NG+ YRG T +GR CQ W PH H P + + GL NYCRNPD
Sbjct: 481 VQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA 540
Query: 262 RPWCYTTDPQIEREFCDLPRCG---------------------SEAQPRQEATTVS-CFR 299
P+CYT DP + E+C+L +C SE P ++ V C+
Sbjct: 541 APYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYH 600
Query: 300 GKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFT 359
G G+ YRGT +TT G CQ W + PH H TPE Y L N+CRNPD AP+C+T
Sbjct: 601 GNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYT 660
Query: 360 LRPGMRAAFCYQIRRCTD--------------------------DVRP--QDCYHGAGEQ 391
PG+R +C + +C+D + RP Q+CYHG G+
Sbjct: 661 RDPGVRWEYC-NLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQS 719
Query: 392 YRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPR 451
YRGT S T G CQ WS+ TPH T P+A L N+CRNPD + P+CYT DP
Sbjct: 720 YRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA-APYCYTRDPG 778
Query: 452 TPFDYCALRRCADDQPPSILDP 473
++YC L +C+D + ++ P
Sbjct: 779 VRWEYCNLTQCSDAEGTAVAPP 800
Score = 290 bits (742), Expect = 3e-78
Identities = 162/453 (35%), Positives = 213/453 (47%), Gaps = 92/453 (20%)
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTL--RNGLEENFCRN 173
+++ V+ C NG YRGT +TTV G CQAWS P+ H TP GL N+CRN
Sbjct: 590 EQRPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRN 649
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCREAA----------------------------- 204
PD P+CYT DP VR++ C + C +A
Sbjct: 650 PDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPG 708
Query: 205 ---CVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSE 261
C NG+ YRG T +GR CQ W PH H P + + GL NYCRNPD
Sbjct: 709 VQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA 768
Query: 262 RPWCYTTDPQIEREFCDLPRCG---------------------SEAQPRQEATTVS-CFR 299
P+CYT DP + E+C+L +C SE P ++ V C+
Sbjct: 769 APYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYH 828
Query: 300 GKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFT 359
G G+ YRGT +TT G CQ W + PH H TPE Y L N+CRNPD AP+C+T
Sbjct: 829 GNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDPVAAPYCYT 888
Query: 360 LRPGMRAAFCYQIRRCTD--------------------------DVRP--QDCYHGAGEQ 391
P +R +C + +C+D + RP Q+CYHG G+
Sbjct: 889 RDPSVRWEYC-NLTQCSDAEGTAVAPPTITPIPSLEAPSEQAPTEQRPGVQECYHGNGQS 947
Query: 392 YRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPR 451
Y+GT T G CQ WS+ TPH T P+A L +N+CRNPD + PWCYT DP
Sbjct: 948 YQGTYFITVTGRTCQAWSSMTPHSHSRTPAYYPNAGLIKNYCRNPDPVA-APWCYTTDPS 1006
Query: 452 TPFDYCALRRCADDQ-----PPSILDPPDQVQF 479
++YC L RC+D + PP+++ P F
Sbjct: 1007 VRWEYCNLTRCSDAEWTAFVPPNVILAPSLEAF 1039
Score = 285 bits (730), Expect = 8e-77
Identities = 158/442 (35%), Positives = 208/442 (47%), Gaps = 87/442 (19%)
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPT--LRNGLEENFCRN 173
++ V+ C +G YRGT +TTV G CQAWS P+ H T GL N+CRN
Sbjct: 20 EQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIMNYCRN 79
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCREA------------------------------ 203
PD P+CYT DP VR++ C + C +A
Sbjct: 80 PDA-VAAPYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPG 138
Query: 204 --ACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSE 261
C NG+ YRG T +GR CQ W PH H P + + GL NYCRNPD
Sbjct: 139 VQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA 198
Query: 262 RPWCYTTDPQIEREFCDLPRCG---------------------SEAQPRQEATTV-SCFR 299
P+CYT DP + E+C+L +C SE P ++ V C+
Sbjct: 199 APYCYTRDPGVRWEYCNLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYH 258
Query: 300 GKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFT 359
G G+ YRGT +TT G CQ W + PH H TPE Y L N+CRNPD AP+C+T
Sbjct: 259 GNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVAAPYCYT 318
Query: 360 LRPGMRAAFCYQIRRCTD--------------------------DVRP--QDCYHGAGEQ 391
PG+R +C + +C+D + RP Q+CYHG G+
Sbjct: 319 RDPGVRWEYC-NLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQRPGVQECYHGNGQS 377
Query: 392 YRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPR 451
YRGT S T G CQ WS+ TPH T P+A L N+CRNPD + P+CYT DP
Sbjct: 378 YRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPDAVA-APYCYTRDPG 436
Query: 452 TPFDYCALRRCADDQPPSILDP 473
++YC L +C+D + ++ P
Sbjct: 437 VRWEYCNLTQCSDAEGTAVAPP 458
Score = 219 bits (558), Expect = 7e-57
Identities = 115/302 (38%), Positives = 141/302 (46%), Gaps = 49/302 (16%)
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPT--LRNGLEENFCRN 173
+K V+ C +G YRG +TTV G CQ+WS P+ H+ TP GL EN+CRN
Sbjct: 1494 EKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRN 1553
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCREA------------------------------ 203
PD PWCYTTDP VR++ C + C E
Sbjct: 1554 PDSGK-QPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPV 1612
Query: 204 --ACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSE 261
C NG+ YRG T +GR CQ W PH+H P + + GL NYCRNPD
Sbjct: 1613 VRQCYHGNGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADT 1672
Query: 262 RPWCYTTDPQIEREFCDLPRCGSEAQPRQEATTV------------SCFRGKGEGYRGTA 309
PWC+T DP I E+C+L RC TV C G G+GYRG
Sbjct: 1673 GPWCFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKK 1732
Query: 310 NTTTAGVPCQRWDAQIPHQH-RFTPEKYACKDLRENFCRNPDGS-EAPWCFTLRPGMRAA 367
TT G PCQ W AQ PH+H F P L +N+CRNPDG PWC+T+ P
Sbjct: 1733 ATTVTGTPCQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFD 1792
Query: 368 FC 369
+C
Sbjct: 1793 YC 1794
Score = 164 bits (415), Expect = 3e-40
Identities = 84/216 (38%), Positives = 111/216 (51%), Gaps = 30/216 (13%)
Query: 286 AQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENF 345
A P Q C+ G G+ YRGT +TT G CQ W + PHQH T E Y L N+
Sbjct: 17 AAPEQSHVVQDCYHGDGQSYRGTYSTTVTGRTCQAWSSMTPHQHNRTTENYPNAGLIMNY 76
Query: 346 CRNPDGSEAPWCFTLRPGMRAAFCYQIRRCTD--------------------------DV 379
CRNPD AP+C+T PG+R +C + +C+D +
Sbjct: 77 CRNPDAVAAPYCYTRDPGVRWEYC-NLTQCSDAEGTAVAPPTVTPVPSLEAPSEQAPTEQ 135
Query: 380 RP--QDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPD 437
RP Q+CYHG G+ YRGT S T G CQ WS+ TPH T P+A L N+CRNPD
Sbjct: 136 RPGVQECYHGNGQSYRGTYSTTVTGRTCQAWSSMTPHSHSRTPEYYPNAGLIMNYCRNPD 195
Query: 438 GDSHGPWCYTMDPRTPFDYCALRRCADDQPPSILDP 473
+ P+CYT DP ++YC L +C+D + ++ P
Sbjct: 196 AVA-APYCYTRDPGVRWEYCNLTQCSDAEGTAVAPP 230
>gi|58533163 hepatocyte growth factor isoform 2 precursor [Homo
sapiens]
Length = 290
Score = 242 bits (618), Expect = 8e-64
Identities = 118/289 (40%), Positives = 166/289 (57%), Gaps = 13/289 (4%)
Query: 5 WVTVQPPARRMGWLPLLLLLTQCL-----GVPGQRSPLNDFQVLRGTELQHLLHAVVPGP 59
WVT PA + + L LLL G +R+ +++F+ T L + A+
Sbjct: 2 WVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKT 61
Query: 60 WQEDVADAEECAGRC----GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLF 115
+ + AD +CA RC G C+AF ++ + C P+ S + DL+
Sbjct: 62 KKVNTAD--QCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLY 119
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNG--LEENFCRN 173
+ KDY+R CI+ G Y+GT++ T G+ CQ WS P++H + P+ G L+EN+CRN
Sbjct: 120 ENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRN 179
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQH 233
P G+ GGPWC+T++P VR++ C I C E C+ CNGE YRG +D TESG+ CQRWD Q
Sbjct: 180 PRGEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQT 239
Query: 234 PHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRC 282
PH+H F P ++ D+G DDNYCRNPDG RPWCYT DP E+C + C
Sbjct: 240 PHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTC 288
Score = 172 bits (435), Expect = 1e-42
Identities = 76/168 (45%), Positives = 102/168 (60%), Gaps = 7/168 (4%)
Query: 296 SCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSE-A 354
+C GKG Y+GT + T +G+ CQ W + IPH+H F P Y KDL+EN+CRNP G E
Sbjct: 127 NCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGG 186
Query: 355 PWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPH 414
PWCFT P +R C I +C++ +C GE YRG + T G CQRW +TPH
Sbjct: 187 PWCFTSNPEVRYEVC-DIPQCSE----VECMTCNGESYRGLMDHTESGKICQRWDHQTPH 241
Query: 415 KPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRC 462
+ +F P ++N+CRNPDG PWCYT+DP T ++YCA++ C
Sbjct: 242 RHKFLPERYPDKGFDDNYCRNPDGQPR-PWCYTLDPHTRWEYCAIKTC 288
Score = 170 bits (431), Expect = 4e-42
Identities = 75/172 (43%), Positives = 100/172 (58%), Gaps = 12/172 (6%)
Query: 205 CVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSER-P 263
C+ G Y+G V T+SG +CQ W PH+H F P + + L +NYCRNP G E P
Sbjct: 128 CIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGP 187
Query: 264 WCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDA 323
WC+T++P++ E CD+P+C V C GE YRG + T +G CQRWD
Sbjct: 188 WCFTSNPEVRYEVCDIPQCSE----------VECMTCNGESYRGLMDHTESGKICQRWDH 237
Query: 324 QIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRC 375
Q PH+H+F PE+Y K +N+CRNPDG PWC+TL P R +C I+ C
Sbjct: 238 QTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYC-AIKTC 288
Score = 89.0 bits (219), Expect = 1e-17
Identities = 34/83 (40%), Positives = 54/83 (65%)
Query: 382 QDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSH 441
++C G G Y+GTVS T+ G++CQ WS+ PH+ F +S L+EN+CRNP G+
Sbjct: 126 RNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEG 185
Query: 442 GPWCYTMDPRTPFDYCALRRCAD 464
GPWC+T +P ++ C + +C++
Sbjct: 186 GPWCFTSNPEVRYEVCDIPQCSE 208
>gi|58533165 hepatocyte growth factor isoform 4 precursor [Homo
sapiens]
Length = 285
Score = 238 bits (608), Expect = 1e-62
Identities = 117/287 (40%), Positives = 163/287 (56%), Gaps = 14/287 (4%)
Query: 5 WVTVQPPARRMGWLPLLLLLTQCL-----GVPGQRSPLNDFQVLRGTELQHLLHAVVPGP 59
WVT PA + + L LLL G +R+ +++F+ T L + A+
Sbjct: 2 WVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKT 61
Query: 60 WQEDVADAEECAGRC----GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLF 115
+ + AD +CA RC G C+AF ++ + C P+ S + DL+
Sbjct: 62 KKVNTAD--QCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLY 119
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNGLEENFCRNPD 175
+ KDY+R CI+ G Y+GT++ T G+ CQ WS P++H Y L+EN+CRNP
Sbjct: 120 ENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSYRG---KDLQENYCRNPR 176
Query: 176 GDPGGPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPH 235
G+ GGPWC+T++P VR++ C I C E C+ CNGE YRG +D TESG+ CQRWD Q PH
Sbjct: 177 GEEGGPWCFTSNPEVRYEVCDIPQCSEVECMTCNGESYRGLMDHTESGKICQRWDHQTPH 236
Query: 236 QHPFEPGKFLDQGLDDNYCRNPDGSERPWCYTTDPQIEREFCDLPRC 282
+H F P ++ D+G DDNYCRNPDG RPWCYT DP E+C + C
Sbjct: 237 RHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYCAIKTC 283
Score = 161 bits (408), Expect = 2e-39
Identities = 74/168 (44%), Positives = 100/168 (59%), Gaps = 12/168 (7%)
Query: 296 SCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSEA- 354
+C GKG Y+GT + T +G+ CQ W + IPH+H Y KDL+EN+CRNP G E
Sbjct: 127 NCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEH-----SYRGKDLQENYCRNPRGEEGG 181
Query: 355 PWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPH 414
PWCFT P +R C I +C++ +C GE YRG + T G CQRW +TPH
Sbjct: 182 PWCFTSNPEVRYEVC-DIPQCSE----VECMTCNGESYRGLMDHTESGKICQRWDHQTPH 236
Query: 415 KPQFTFTSEPHAQLEENFCRNPDGDSHGPWCYTMDPRTPFDYCALRRC 462
+ +F P ++N+CRNPDG PWCYT+DP T ++YCA++ C
Sbjct: 237 RHKFLPERYPDKGFDDNYCRNPDGQPR-PWCYTLDPHTRWEYCAIKTC 283
Score = 161 bits (407), Expect = 2e-39
Identities = 73/172 (42%), Positives = 98/172 (56%), Gaps = 17/172 (9%)
Query: 205 CVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSER-P 263
C+ G Y+G V T+SG +CQ W PH+H + + L +NYCRNP G E P
Sbjct: 128 CIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSYR-----GKDLQENYCRNPRGEEGGP 182
Query: 264 WCYTTDPQIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDA 323
WC+T++P++ E CD+P+C V C GE YRG + T +G CQRWD
Sbjct: 183 WCFTSNPEVRYEVCDIPQCSE----------VECMTCNGESYRGLMDHTESGKICQRWDH 232
Query: 324 QIPHQHRFTPEKYACKDLRENFCRNPDGSEAPWCFTLRPGMRAAFCYQIRRC 375
Q PH+H+F PE+Y K +N+CRNPDG PWC+TL P R +C I+ C
Sbjct: 233 QTPHRHKFLPERYPDKGFDDNYCRNPDGQPRPWCYTLDPHTRWEYC-AIKTC 283
Score = 82.8 bits (203), Expect = 1e-15
Identities = 32/83 (38%), Positives = 52/83 (62%), Gaps = 5/83 (6%)
Query: 382 QDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSH 441
++C G G Y+GTVS T+ G++CQ WS+ PH+ + L+EN+CRNP G+
Sbjct: 126 RNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSYR-----GKDLQENYCRNPRGEEG 180
Query: 442 GPWCYTMDPRTPFDYCALRRCAD 464
GPWC+T +P ++ C + +C++
Sbjct: 181 GPWCFTSNPEVRYEVCDIPQCSE 203
>gi|4503635 coagulation factor II preproprotein [Homo sapiens]
Length = 622
Score = 175 bits (443), Expect = 2e-43
Identities = 144/530 (27%), Positives = 211/530 (39%), Gaps = 91/530 (17%)
Query: 282 CGSEAQPRQEATTV---SCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYAC 338
C + PR + +C G G YRG N T +G+ CQ W ++ PH+ +
Sbjct: 90 CETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPG 149
Query: 339 KDLRENFCRNPDGS-EAPWCFTLRPGMRAAFCYQIRRCTDD-----VRP----------- 381
DL+ENFCRNPD S PWC+T P +R C I C D + P
Sbjct: 150 ADLQENFCRNPDSSTTGPWCYTTDPTVRRQEC-SIPVCGQDQVTVAMTPRSEGSSVNLSP 208
Query: 382 --QDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGD 439
+ C G+QY+G ++ T G+ C W++ QL ENFCRNPDGD
Sbjct: 209 PLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGD 268
Query: 440 SHGPWCYTMDPRTPFDYCALRRC---ADDQPPSILDPPDQVQFE---------------- 480
G WCY F YC L C +++ LD E
Sbjct: 269 EEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRT 328
Query: 481 ------KCG-----KRVDRLDQRRSKL-------RVVGGHP---GNSPWTVSLRNRQGQH 519
CG ++ D+ +L R+V G G SPW V L + Q
Sbjct: 329 FGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQE 388
Query: 520 -FCGGSLVKEQWILTARQC--FSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVP-VAKMV 575
CG SL+ ++W+LTA C + T ++ + + E +++++ + K+
Sbjct: 389 LLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIY 448
Query: 576 CGPS-------GSQLVLLKLERSVTLNQRVALICLPPE---WYVVPPGTKCEIAGWGETK 625
P + L+KL++ V + + +CLP ++ G K + GWG K
Sbjct: 449 IHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLK 508
Query: 626 -------GTGNDTVLNVALLNVISNQECNIKHRGRVRESEMCTEGLLAPVG----ACEGD 674
G G +VL V L ++ C R R+ ++ C G G ACEGD
Sbjct: 509 ETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCA-GYKPDEGKRGDACEGD 567
Query: 675 YGGPLACFT--HNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVM 722
GGP + +N W GI+ C R +T V WI KV+
Sbjct: 568 SGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVI 617
Score = 125 bits (314), Expect = 1e-28
Identities = 70/195 (35%), Positives = 94/195 (48%), Gaps = 15/195 (7%)
Query: 184 YTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGK 243
YT R + +C E C G YRG V+ T SG ECQ W ++PH+
Sbjct: 87 YTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTT 146
Query: 244 FLDQGLDDNYCRNPDGSER-PWCYTTDPQIEREFCDLPRCGSE-----AQPRQEATTVS- 296
L +N+CRNPD S PWCYTTDP + R+ C +P CG + PR E ++V+
Sbjct: 147 HPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNL 206
Query: 297 ------CFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPD 350
C +G+ Y+G TT G+PC W + + + L ENFCRNPD
Sbjct: 207 SPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPD 266
Query: 351 G-SEAPWCFTL-RPG 363
G E WC+ +PG
Sbjct: 267 GDEEGVWCYVAGKPG 281
Score = 110 bits (274), Expect = 6e-24
Identities = 64/195 (32%), Positives = 83/195 (42%), Gaps = 30/195 (15%)
Query: 118 KDYVRTCIMNN-----GVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNG--LEENF 170
+D + C+ N G YRG + T G+ CQ W ++P+ + T G L+ENF
Sbjct: 97 RDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENF 156
Query: 171 CRNPDGDPGGPWCYTTDPAVRFQSCGIKSCRE----------------------AACVWC 208
CRNPD GPWCYTTDP VR Q C I C + CV
Sbjct: 157 CRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPD 216
Query: 209 NGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSER-PWCYT 267
G++Y+G + T G C W L +N+CRNPDG E WCY
Sbjct: 217 RGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYV 276
Query: 268 TDPQIEREFCDLPRC 282
+ +CDL C
Sbjct: 277 AGKPGDFGYCDLNYC 291
Score = 66.6 bits (161), Expect = 8e-11
Identities = 43/125 (34%), Positives = 57/125 (45%), Gaps = 12/125 (9%)
Query: 124 CIMNNGVGYRGTMATTVGGLPCQAWSH---KFPNDHK-YTPTLRNGLEENFCRNPDGDPG 179
C+ + G Y+G +A T GLPC AW+ K + H+ + ++ L ENFCRNPDGD
Sbjct: 213 CVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQ--LVENFCRNPDGDEE 270
Query: 180 GPWCYTTDPAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPF 239
G WCY F C + C EA EE G +S R + +Q F
Sbjct: 271 GVWCYVAGKPGDFGYCDLNYCEEAV------EEETGDGLDEDSDRAIEGRTATSEYQTFF 324
Query: 240 EPGKF 244
P F
Sbjct: 325 NPRTF 329
>gi|4505861 plasminogen activator, tissue isoform 1 preproprotein
[Homo sapiens]
Length = 562
Score = 174 bits (441), Expect = 3e-43
Identities = 135/464 (29%), Positives = 196/464 (42%), Gaps = 58/464 (12%)
Query: 293 TTVSCFRGKGEGYRGTANTTTAGVPCQRWD----AQIPHQHRFTPEKYACKDLRENFCRN 348
T +C+ +G YRGT +T +G C W+ AQ P+ R P+ N+CRN
Sbjct: 123 TRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGR-RPDAIRLGLGNHNYCRN 181
Query: 349 PDGSEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRW 408
PD PWC+ + G ++ C++ DCY G G YRGT S T G C W
Sbjct: 182 PDRDSKPWCYVFKAGKYSSEFCSTPACSEG--NSDCYFGNGSAYRGTHSLTESGASCLPW 239
Query: 409 SAETPHKPQFTFTSEPHAQL----EENFCRNPDGDSHGPWCYTM-DPRTPFDYCALRRCA 463
++ +T P AQ + N+CRNPDGD+ PWC+ + + R ++YC + C+
Sbjct: 240 NSMILIGKVYT-AQNPSAQALGLGKHNYCRNPDGDAK-PWCHVLKNRRLTWEYCDVPSCS 297
Query: 464 DDQPPSILDPPDQVQFEKCGKRVDRLDQRRSK---LRVVGGHPGNSPWTVSLRNRQGQHF 520
CG R Q R K + HP + R G+ F
Sbjct: 298 T-----------------CGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERF 340
Query: 521 -CGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPS 579
CGG L+ WIL+A CF P V LG ++ E Q+ V K +
Sbjct: 341 LCGGILISSCWILSAAHCFQE-RFPPHHLTVILGRTYRVVPGEEE--QKFEVEKYIVHKE 397
Query: 580 ------GSQLVLLKLE----RSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGN 629
+ + LL+L+ R + V +CLPP +P T+CE++G+G+ +
Sbjct: 398 FDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSP 457
Query: 630 --DTVLNVALLNVISNQECNIKHR-GRVRESEMCTEGLLAPVG-------ACEGDYGGPL 679
L A + + + C +H R M G G AC+GD GGPL
Sbjct: 458 FYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPL 517
Query: 680 ACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMR 723
C L GII C + P V+T+V+ ++DWI MR
Sbjct: 518 VCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMR 561
Score = 108 bits (271), Expect = 1e-23
Identities = 79/250 (31%), Positives = 111/250 (44%), Gaps = 51/250 (20%)
Query: 123 TCIMNNGVGYRGTMATTVGGLPCQAWSHKF----PNDHKYTPTLRNGL-EENFCRNPDGD 177
TC + G+ YRGT +T G C W+ P + +R GL N+CRNPD D
Sbjct: 126 TCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRD 185
Query: 178 PGGPWCYTTDPAVRFQS--CGIKSCRE--AACVWCNGEEYRGAVDRTESGRECQRWD--- 230
PWCY A ++ S C +C E + C + NG YRG TESG C W+
Sbjct: 186 -SKPWCYVFK-AGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMI 243
Query: 231 -------LQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYT-TDPQIEREFCDLPRC 282
Q+P GK NYCRNPDG +PWC+ + ++ E+CD+P C
Sbjct: 244 LIGKVYTAQNPSAQALGLGKH-------NYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSC 296
Query: 283 GS-----EAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTP-EKY 336
+ +QP+ FR KG + A + W A I +HR +P E++
Sbjct: 297 STCGLRQYSQPQ--------FRIKGGLF--------ADIASHPWQAAIFAKHRRSPGERF 340
Query: 337 ACKDLRENFC 346
C + + C
Sbjct: 341 LCGGILISSC 350
Score = 104 bits (259), Expect = 3e-22
Identities = 59/166 (35%), Positives = 78/166 (46%), Gaps = 15/166 (9%)
Query: 203 AACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGK--FLDQGL-DDNYCRNPDG 259
A C G YRG ESG EC W+ Q P+ + + GL + NYCRNPD
Sbjct: 125 ATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDR 184
Query: 260 SERPWCYTTDP-QIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPC 318
+PWCY + EFC P C SE C+ G G YRGT + T +G C
Sbjct: 185 DSKPWCYVFKAGKYSSEFCSTPAC-SEGNS-------DCYFGNGSAYRGTHSLTESGASC 236
Query: 319 QRWDAQIPHQHRFTPEKYACKDL---RENFCRNPDGSEAPWCFTLR 361
W++ I +T + + + L + N+CRNPDG PWC L+
Sbjct: 237 LPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLK 282
Score = 53.5 bits (127), Expect = 7e-07
Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 6/94 (6%)
Query: 375 CTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQL---EEN 431
C D R CY G YRGT S G +C W++ + ++ +L N
Sbjct: 119 CEIDTRAT-CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHN 177
Query: 432 FCRNPDGDSHGPWCYTMDP-RTPFDYCALRRCAD 464
+CRNPD DS PWCY + ++C+ C++
Sbjct: 178 YCRNPDRDSK-PWCYVFKAGKYSSEFCSTPACSE 210
>gi|14702169 plasminogen activator, tissue isoform 3 preproprotein
[Homo sapiens]
Length = 516
Score = 174 bits (441), Expect = 3e-43
Identities = 135/464 (29%), Positives = 196/464 (42%), Gaps = 58/464 (12%)
Query: 293 TTVSCFRGKGEGYRGTANTTTAGVPCQRWD----AQIPHQHRFTPEKYACKDLRENFCRN 348
T +C+ +G YRGT +T +G C W+ AQ P+ R P+ N+CRN
Sbjct: 77 TRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGR-RPDAIRLGLGNHNYCRN 135
Query: 349 PDGSEAPWCFTLRPGMRAAFCYQIRRCTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRW 408
PD PWC+ + G ++ C++ DCY G G YRGT S T G C W
Sbjct: 136 PDRDSKPWCYVFKAGKYSSEFCSTPACSEG--NSDCYFGNGSAYRGTHSLTESGASCLPW 193
Query: 409 SAETPHKPQFTFTSEPHAQL----EENFCRNPDGDSHGPWCYTM-DPRTPFDYCALRRCA 463
++ +T P AQ + N+CRNPDGD+ PWC+ + + R ++YC + C+
Sbjct: 194 NSMILIGKVYT-AQNPSAQALGLGKHNYCRNPDGDAK-PWCHVLKNRRLTWEYCDVPSCS 251
Query: 464 DDQPPSILDPPDQVQFEKCGKRVDRLDQRRSK---LRVVGGHPGNSPWTVSLRNRQGQHF 520
CG R Q R K + HP + R G+ F
Sbjct: 252 T-----------------CGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERF 294
Query: 521 -CGGSLVKEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPS 579
CGG L+ WIL+A CF P V LG ++ E Q+ V K +
Sbjct: 295 LCGGILISSCWILSAAHCFQE-RFPPHHLTVILGRTYRVVPGEEE--QKFEVEKYIVHKE 351
Query: 580 ------GSQLVLLKLE----RSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGN 629
+ + LL+L+ R + V +CLPP +P T+CE++G+G+ +
Sbjct: 352 FDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSP 411
Query: 630 --DTVLNVALLNVISNQECNIKHR-GRVRESEMCTEGLLAPVG-------ACEGDYGGPL 679
L A + + + C +H R M G G AC+GD GGPL
Sbjct: 412 FYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPL 471
Query: 680 ACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMR 723
C L GII C + P V+T+V+ ++DWI MR
Sbjct: 472 VCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMR 515
Score = 108 bits (271), Expect = 1e-23
Identities = 79/250 (31%), Positives = 111/250 (44%), Gaps = 51/250 (20%)
Query: 123 TCIMNNGVGYRGTMATTVGGLPCQAWSHKF----PNDHKYTPTLRNGL-EENFCRNPDGD 177
TC + G+ YRGT +T G C W+ P + +R GL N+CRNPD D
Sbjct: 80 TCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRD 139
Query: 178 PGGPWCYTTDPAVRFQS--CGIKSCRE--AACVWCNGEEYRGAVDRTESGRECQRWD--- 230
PWCY A ++ S C +C E + C + NG YRG TESG C W+
Sbjct: 140 -SKPWCYVFK-AGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMI 197
Query: 231 -------LQHPHQHPFEPGKFLDQGLDDNYCRNPDGSERPWCYT-TDPQIEREFCDLPRC 282
Q+P GK NYCRNPDG +PWC+ + ++ E+CD+P C
Sbjct: 198 LIGKVYTAQNPSAQALGLGKH-------NYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSC 250
Query: 283 GS-----EAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTP-EKY 336
+ +QP+ FR KG + A + W A I +HR +P E++
Sbjct: 251 STCGLRQYSQPQ--------FRIKGGLF--------ADIASHPWQAAIFAKHRRSPGERF 294
Query: 337 ACKDLRENFC 346
C + + C
Sbjct: 295 LCGGILISSC 304
Score = 104 bits (259), Expect = 3e-22
Identities = 59/166 (35%), Positives = 78/166 (46%), Gaps = 15/166 (9%)
Query: 203 AACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGK--FLDQGL-DDNYCRNPDG 259
A C G YRG ESG EC W+ Q P+ + + GL + NYCRNPD
Sbjct: 79 ATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDR 138
Query: 260 SERPWCYTTDP-QIEREFCDLPRCGSEAQPRQEATTVSCFRGKGEGYRGTANTTTAGVPC 318
+PWCY + EFC P C SE C+ G G YRGT + T +G C
Sbjct: 139 DSKPWCYVFKAGKYSSEFCSTPAC-SEGNS-------DCYFGNGSAYRGTHSLTESGASC 190
Query: 319 QRWDAQIPHQHRFTPEKYACKDL---RENFCRNPDGSEAPWCFTLR 361
W++ I +T + + + L + N+CRNPDG PWC L+
Sbjct: 191 LPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLK 236
Score = 53.5 bits (127), Expect = 7e-07
Identities = 29/94 (30%), Positives = 43/94 (45%), Gaps = 6/94 (6%)
Query: 375 CTDDVRPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQL---EEN 431
C D R CY G YRGT S G +C W++ + ++ +L N
Sbjct: 73 CEIDTRAT-CYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHN 131
Query: 432 FCRNPDGDSHGPWCYTMDP-RTPFDYCALRRCAD 464
+CRNPD DS PWCY + ++C+ C++
Sbjct: 132 YCRNPDRDSK-PWCYVFKAGKYSSEFCSTPACSE 164
>gi|4504383 HGF activator preproprotein [Homo sapiens]
Length = 655
Score = 156 bits (394), Expect = 7e-38
Identities = 121/392 (30%), Positives = 176/392 (44%), Gaps = 46/392 (11%)
Query: 362 PGMRAAFCYQIRRCTDDVRPQD-CYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTF 420
PG C ++ P + C+ G G YRG S + G+ C W+++ ++
Sbjct: 271 PGFAGRLC--------NIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVD 322
Query: 421 TSEPHAQL---EENFCRNPDGDSHGPWCYTM-DPRTPFDYCALRRCAD----DQPPSIL- 471
+ A L +CRNPD D PWCY + D ++YC L C P +L
Sbjct: 323 SVGAAALLGLGPHAYCRNPDNDER-PWCYVVKDSALSWEYCRLEACESLTRVQLSPDLLA 381
Query: 472 --DPPDQVQFEKCGKRVDRLDQRRSKLRVVGGH---PGNSPWTVSLRNRQGQHFCGGSLV 526
P + CG+R + R R++GG PG+ PW ++ G FC GSLV
Sbjct: 382 TLPEPASPGRQACGRRHKKRTFLRP--RIIGGSSSLPGSHPWLAAIYI--GDSFCAGSLV 437
Query: 527 KEQWILTARQCFSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKM-------VCGPS 579
W+++A CFS P V LG F N Q + K V PS
Sbjct: 438 HTCWVVSAAHCFSHSP-PRDSVSVVLGQHFFN--RTTDVTQTFGIEKYIPYTLYSVFNPS 494
Query: 580 GSQLVLLKL----ERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWG--ETKGTGNDTVL 633
LVL++L +R T +Q V ICLP P G KC+IAGWG + +G + L
Sbjct: 495 DHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSL 554
Query: 634 NVALLNVISNQECNIK--HRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEG 691
AL+ ++++ +C+ + + + +C AC+GD GGPLAC + L G
Sbjct: 555 REALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYG 614
Query: 692 IIIPNRVCARSRWPAVFTRVSVFVDWIHKVMR 723
II C R P V+TRV+ +VDWI+ +R
Sbjct: 615 IISWGDGCGRLHKPGVYTRVANYVDWINDRIR 646
Score = 60.8 bits (146), Expect = 4e-09
Identities = 37/101 (36%), Positives = 45/101 (44%), Gaps = 6/101 (5%)
Query: 188 PAVRFQSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRW--DLQHPHQHPFEPGKFL 245
P + C I+ + C NG YRG + SG C W DL + H G
Sbjct: 271 PGFAGRLCNIEP--DERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAA 328
Query: 246 DQGLDDN-YCRNPDGSERPWCYTT-DPQIEREFCDLPRCGS 284
GL + YCRNPD ERPWCY D + E+C L C S
Sbjct: 329 LLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACES 369
Score = 58.9 bits (141), Expect = 2e-08
Identities = 28/89 (31%), Positives = 43/89 (48%), Gaps = 3/89 (3%)
Query: 297 CFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDL---RENFCRNPDGSE 353
CF G G GYRG A+T+ +G+ C W++ + +Q A L +CRNPD E
Sbjct: 286 CFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDE 345
Query: 354 APWCFTLRPGMRAAFCYQIRRCTDDVRPQ 382
PWC+ ++ + ++ C R Q
Sbjct: 346 RPWCYVVKDSALSWEYCRLEACESLTRVQ 374
Score = 56.6 bits (135), Expect = 8e-08
Identities = 29/83 (34%), Positives = 44/83 (53%), Gaps = 7/83 (8%)
Query: 124 CIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRN----GLEEN-FCRNPDGDP 178
C + NG GYRG +T+ GL C AW+ + ++ GL + +CRNPD D
Sbjct: 286 CFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDE 345
Query: 179 GGPWCYTT-DPAVRFQSCGIKSC 200
PWCY D A+ ++ C +++C
Sbjct: 346 -RPWCYVVKDSALSWEYCRLEAC 367
>gi|222537759 plasminogen activator, urokinase isoform 2 [Homo
sapiens]
Length = 414
Score = 144 bits (364), Expect = 2e-34
Identities = 110/367 (29%), Positives = 165/367 (44%), Gaps = 41/367 (11%)
Query: 380 RPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQL---EENFCRNP 436
+ + CY G G YRG S G C W++ T + + QL + N+CRNP
Sbjct: 49 KSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNP 108
Query: 437 DGDSHGPWCYTMDPRTPF-DYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSK 495
D + PWCY P C + CAD + PS PP++++F+ CG++ R +
Sbjct: 109 D-NRRRPWCYVQVGLKPLVQECMVHDCADGKKPS--SPPEELKFQ-CGQKT-----LRPR 159
Query: 496 LRVVGGH---PGNSPWTVSL--RNRQGQ--HFCGGSLVKEQWILTARQCFSSCHMPLTGY 548
+++GG N PW ++ R+R G + CGGSL+ W+++A CF + Y
Sbjct: 160 FKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID-YPKKEDY 218
Query: 549 EVWLGTLFQNPQ-HGEPSLQRVPVAKMVCGPSGS--------QLVLLKLE----RSVTLN 595
V+LG N GE + V ++ S + LLK+ R +
Sbjct: 219 IVYLGRSRLNSNTQGEMKFE---VENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPS 275
Query: 596 QRVALICLPPEWYVVPPGTKCEIAGWGETKGTGN--DTVLNVALLNVISNQECNIKHR-- 651
+ + ICLP + GT CEI G+G+ T L + ++ +IS++EC H
Sbjct: 276 RTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYG 335
Query: 652 GRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRV 711
V +C +C+GD GGPL C L GI+ R CA P V+TRV
Sbjct: 336 SEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRV 395
Query: 712 SVFVDWI 718
S F+ WI
Sbjct: 396 SHFLPWI 402
Score = 58.2 bits (139), Expect = 3e-08
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 296 SCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDL---RENFCRNPDGS 352
+C+ G G YRG A+T T G PC W++ Q + + L + N+CRNPD
Sbjct: 52 TCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNR 111
Query: 353 EAPWCFT---LRPGMRAAFCYQIRRCTDDVRP 381
PWC+ L+P ++ + C D +P
Sbjct: 112 RRPWCYVQVGLKPLVQEC---MVHDCADGKKP 140
Score = 50.4 bits (119), Expect = 6e-06
Identities = 46/158 (29%), Positives = 58/158 (36%), Gaps = 20/158 (12%)
Query: 193 QSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKF--LDQGLD 250
Q C I + C NG YRG GR C W+ Q + + L GL
Sbjct: 43 QHCEIDKSK--TCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLG 100
Query: 251 D-NYCRNPDGSERPWCYT---TDPQIEREFCDLPRCGSEAQPRQ--EATTVSC----FRG 300
NYCRNPD RPWCY P ++ C + C +P E C R
Sbjct: 101 KHNYCRNPDNRRRPWCYVQVGLKPLVQE--CMVHDCADGKKPSSPPEELKFQCGQKTLRP 158
Query: 301 KGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYAC 338
+ + G T + Q W A I +HR Y C
Sbjct: 159 RFKIIGGEFTT----IENQPWFAAIYRRHRGGSVTYVC 192
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 11/92 (11%)
Query: 119 DYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKY----TPTLRNGL-EENFCRN 173
D +TC NG YRG +T G PC W+ Y + L+ GL + N+CRN
Sbjct: 48 DKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRN 107
Query: 174 PDGDPGGPWCYT---TDPAVRFQSCGIKSCRE 202
PD + PWCY P V Q C + C +
Sbjct: 108 PD-NRRRPWCYVQVGLKPLV--QECMVHDCAD 136
>gi|4505863 plasminogen activator, urokinase isoform 1 preproprotein
[Homo sapiens]
Length = 431
Score = 144 bits (364), Expect = 2e-34
Identities = 110/367 (29%), Positives = 165/367 (44%), Gaps = 41/367 (11%)
Query: 380 RPQDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQL---EENFCRNP 436
+ + CY G G YRG S G C W++ T + + QL + N+CRNP
Sbjct: 66 KSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNP 125
Query: 437 DGDSHGPWCYTMDPRTPF-DYCALRRCADDQPPSILDPPDQVQFEKCGKRVDRLDQRRSK 495
D + PWCY P C + CAD + PS PP++++F+ CG++ R +
Sbjct: 126 D-NRRRPWCYVQVGLKPLVQECMVHDCADGKKPS--SPPEELKFQ-CGQKT-----LRPR 176
Query: 496 LRVVGGH---PGNSPWTVSL--RNRQGQ--HFCGGSLVKEQWILTARQCFSSCHMPLTGY 548
+++GG N PW ++ R+R G + CGGSL+ W+++A CF + Y
Sbjct: 177 FKIIGGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFID-YPKKEDY 235
Query: 549 EVWLGTLFQNPQ-HGEPSLQRVPVAKMVCGPSGS--------QLVLLKLE----RSVTLN 595
V+LG N GE + V ++ S + LLK+ R +
Sbjct: 236 IVYLGRSRLNSNTQGEMKFE---VENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPS 292
Query: 596 QRVALICLPPEWYVVPPGTKCEIAGWGETKGTGN--DTVLNVALLNVISNQECNIKHR-- 651
+ + ICLP + GT CEI G+G+ T L + ++ +IS++EC H
Sbjct: 293 RTIQTICLPSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYG 352
Query: 652 GRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRV 711
V +C +C+GD GGPL C L GI+ R CA P V+TRV
Sbjct: 353 SEVTTKMLCAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRV 412
Query: 712 SVFVDWI 718
S F+ WI
Sbjct: 413 SHFLPWI 419
Score = 58.2 bits (139), Expect = 3e-08
Identities = 29/92 (31%), Positives = 44/92 (47%), Gaps = 9/92 (9%)
Query: 296 SCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDL---RENFCRNPDGS 352
+C+ G G YRG A+T T G PC W++ Q + + L + N+CRNPD
Sbjct: 69 TCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRNPDNR 128
Query: 353 EAPWCFT---LRPGMRAAFCYQIRRCTDDVRP 381
PWC+ L+P ++ + C D +P
Sbjct: 129 RRPWCYVQVGLKPLVQEC---MVHDCADGKKP 157
Score = 50.4 bits (119), Expect = 6e-06
Identities = 46/158 (29%), Positives = 58/158 (36%), Gaps = 20/158 (12%)
Query: 193 QSCGIKSCREAACVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKF--LDQGLD 250
Q C I + C NG YRG GR C W+ Q + + L GL
Sbjct: 60 QHCEIDKSK--TCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLG 117
Query: 251 D-NYCRNPDGSERPWCYT---TDPQIEREFCDLPRCGSEAQPRQ--EATTVSC----FRG 300
NYCRNPD RPWCY P ++ C + C +P E C R
Sbjct: 118 KHNYCRNPDNRRRPWCYVQVGLKPLVQE--CMVHDCADGKKPSSPPEELKFQCGQKTLRP 175
Query: 301 KGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYAC 338
+ + G T + Q W A I +HR Y C
Sbjct: 176 RFKIIGGEFTT----IENQPWFAAIYRRHRGGSVTYVC 209
Score = 48.5 bits (114), Expect = 2e-05
Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 11/92 (11%)
Query: 119 DYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKY----TPTLRNGL-EENFCRN 173
D +TC NG YRG +T G PC W+ Y + L+ GL + N+CRN
Sbjct: 65 DKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHNYCRN 124
Query: 174 PDGDPGGPWCYT---TDPAVRFQSCGIKSCRE 202
PD + PWCY P V Q C + C +
Sbjct: 125 PD-NRRRPWCYVQVGLKPLV--QECMVHDCAD 153
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 134 bits (337), Expect = 3e-31
Identities = 88/254 (34%), Positives = 124/254 (48%), Gaps = 15/254 (5%)
Query: 477 VQFEKCGKRVDRLDQRRSKLRVVGGHPG---NSPWTVSLRNRQGQHFCGGSLVKEQWILT 533
+Q CG R R R+VGG+ PW SL+ QG H CGGS++ WI+T
Sbjct: 202 LQCTACGHR------RGYSSRIVGGNMSLLSQWPWQASLQF-QGYHLCGGSVITPLWIIT 254
Query: 534 ARQCFSSCHMPLTG-YEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSV 592
A C ++P + +V L +L NP + V +K G+ + L+KL +
Sbjct: 255 AAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPL 314
Query: 593 TLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDT--VLNVALLNVISNQECNIK- 649
T N+ + +CLP P G C +GWG T+ D VLN A + +ISN+ CN +
Sbjct: 315 TFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRD 374
Query: 650 -HRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVF 708
+ G + S +C L V +C+GD GGPL C W L G CA P V+
Sbjct: 375 VYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVY 434
Query: 709 TRVSVFVDWIHKVM 722
TRV+ F+DWIH+ M
Sbjct: 435 TRVTSFLDWIHEQM 448
>gi|118498350 chymotrypsin B2 [Homo sapiens]
Length = 263
Score = 132 bits (332), Expect = 1e-30
Identities = 81/238 (34%), Positives = 119/238 (50%), Gaps = 22/238 (9%)
Query: 497 RVVGGH---PGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLG 553
R+V G PG+ PW VSL+++ G HFCGGSL+ E W++TA C + E G
Sbjct: 33 RIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQG 92
Query: 554 TLFQNPQHGEPSLQRVPVAKMVCGPS------GSQLVLLKLERSVTLNQRVALICLPPEW 607
+ E ++Q + +AK+ P + + LLKL +Q V+ +CLP
Sbjct: 93 S-------DEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSAD 145
Query: 608 YVVPPGTKCEIAGWGETKGTGNDT--VLNVALLNVISNQECNIKHRGRVRESEMCTEGLL 665
P GT C GWG+TK N T L A L ++SN EC R+ + +C
Sbjct: 146 DDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAGA-- 203
Query: 666 APVGACEGDYGGPLACFTHNCWVLEGIII-PNRVCARSRWPAVFTRVSVFVDWIHKVM 722
+ V +C GD GGPL C W L GI+ +R C+ + PAV+ RV+ + W+ K++
Sbjct: 204 SGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSRTCSTTT-PAVYARVAKLIPWVQKIL 260
>gi|118498341 chymotrypsin B1 [Homo sapiens]
Length = 263
Score = 130 bits (326), Expect = 6e-30
Identities = 78/237 (32%), Positives = 114/237 (48%), Gaps = 20/237 (8%)
Query: 497 RVVGGH---PGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLG 553
R+V G PG+ PW VSL+++ G HFCGGSL+ E W++TA C + E G
Sbjct: 33 RIVNGEDAVPGSWPWQVSLQDKTGFHFCGGSLISEDWVVTAAHCGVRTSDVVVAGEFDQG 92
Query: 554 TLFQNPQHGEPSLQRVPVAKMVCGPS------GSQLVLLKLERSVTLNQRVALICLPPEW 607
+ E ++Q + +AK+ P + + LLKL +Q V+ +CLP
Sbjct: 93 S-------DEENIQVLKIAKVFKNPKFSILTVNNDITLLKLATPARFSQTVSAVCLPSAD 145
Query: 608 YVVPPGTKCEIAGWGETKGTGNDT--VLNVALLNVISNQECNIKHRGRVRESEMCTEGLL 665
P GT C GWG+TK N T L A L ++SN EC R+ + +C
Sbjct: 146 DDFPAGTLCATTGWGKTKYNANKTPDKLQQAALPLLSNAECKKSWGRRITDVMICAGA-- 203
Query: 666 APVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVM 722
+ V +C GD GGPL C W L GI+ + P V+ RV+ + W+ K++
Sbjct: 204 SGVSSCMGDSGGPLVCQKDGAWTLVGIVSWGSDTCSTSSPGVYARVTKLIPWVQKIL 260
>gi|58533167 hepatocyte growth factor isoform 5 precursor [Homo
sapiens]
Length = 210
Score = 128 bits (321), Expect = 2e-29
Identities = 71/209 (33%), Positives = 110/209 (52%), Gaps = 13/209 (6%)
Query: 5 WVTVQPPARRMGWLPLLLLLTQCL-----GVPGQRSPLNDFQVLRGTELQHLLHAVVPGP 59
WVT PA + + L LLL G +R+ +++F+ T L + A+
Sbjct: 2 WVTKLLPALLLQHVLLHLLLLPIAIPYAEGQRKRRNTIHEFKKSAKTTLIKIDPALKIKT 61
Query: 60 WQEDVADAEECAGRC----GPLMDCRAFHYNVSSHGCQLLPWTQHSPHTRLRRSGRCDLF 115
+ + AD +CA RC G C+AF ++ + C P+ S + DL+
Sbjct: 62 KKVNTAD--QCANRCTRNKGLPFTCKAFVFDKARKQCLWFPFNSMSSGVKKEFGHEFDLY 119
Query: 116 QKKDYVRTCIMNNGVGYRGTMATTVGGLPCQAWSHKFPNDHKYTPTLRNG--LEENFCRN 173
+ KDY+R CI+ G Y+GT++ T G+ CQ WS P++H + P+ G L+EN+CRN
Sbjct: 120 ENKDYIRNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRN 179
Query: 174 PDGDPGGPWCYTTDPAVRFQSCGIKSCRE 202
P G+ GGPWC+T++P VR++ C I C E
Sbjct: 180 PRGEEGGPWCFTSNPEVRYEVCDIPQCSE 208
Score = 94.4 bits (233), Expect = 3e-19
Identities = 40/83 (48%), Positives = 53/83 (63%), Gaps = 2/83 (2%)
Query: 296 SCFRGKGEGYRGTANTTTAGVPCQRWDAQIPHQHRFTPEKYACKDLRENFCRNPDGSE-A 354
+C GKG Y+GT + T +G+ CQ W + IPH+H F P Y KDL+EN+CRNP G E
Sbjct: 127 NCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGG 186
Query: 355 PWCFTLRPGMRAAFCYQIRRCTD 377
PWCFT P +R C I +C++
Sbjct: 187 PWCFTSNPEVRYEVC-DIPQCSE 208
Score = 89.4 bits (220), Expect = 1e-17
Identities = 35/79 (44%), Positives = 50/79 (63%), Gaps = 1/79 (1%)
Query: 205 CVWCNGEEYRGAVDRTESGRECQRWDLQHPHQHPFEPGKFLDQGLDDNYCRNPDGSE-RP 263
C+ G Y+G V T+SG +CQ W PH+H F P + + L +NYCRNP G E P
Sbjct: 128 CIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGP 187
Query: 264 WCYTTDPQIEREFCDLPRC 282
WC+T++P++ E CD+P+C
Sbjct: 188 WCFTSNPEVRYEVCDIPQC 206
Score = 89.0 bits (219), Expect = 1e-17
Identities = 34/83 (40%), Positives = 54/83 (65%)
Query: 382 QDCYHGAGEQYRGTVSKTRKGVQCQRWSAETPHKPQFTFTSEPHAQLEENFCRNPDGDSH 441
++C G G Y+GTVS T+ G++CQ WS+ PH+ F +S L+EN+CRNP G+
Sbjct: 126 RNCIIGKGRSYKGTVSITKSGIKCQPWSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEG 185
Query: 442 GPWCYTMDPRTPFDYCALRRCAD 464
GPWC+T +P ++ C + +C++
Sbjct: 186 GPWCFTSNPEVRYEVCDIPQCSE 208
>gi|117956391 protease, serine, 33 [Homo sapiens]
Length = 280
Score = 126 bits (316), Expect = 8e-29
Identities = 85/257 (33%), Positives = 118/257 (45%), Gaps = 25/257 (9%)
Query: 483 GKRVDRLDQRRSKLRVVGGHPGNS---PWTVSLRNRQGQHFCGGSLVKEQWILTARQCFS 539
G++ Q R R+VGG G PW S+++R G H CGGSL+ QW+LTA CF
Sbjct: 22 GRKSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHR-GAHVCGGSLIAPQWVLTAAHCFP 80
Query: 540 SCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPSGSQ------LVLLKLERSVT 593
+P Y V LG L P VPV +++ P S+ L LL+L R V
Sbjct: 81 RRALPAE-YRVRLGALRLGST--SPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVP 137
Query: 594 LNQRVALICLPPEWYVVPPGTKCEIAGWGETKG---TGNDTVLNVALLNVISNQECN-IK 649
L+ RV +CLP PPGT C + GWG + L + ++ ++ C+ +
Sbjct: 138 LSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLY 197
Query: 650 HRGR--------VRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCAR 701
H G V +C AC+GD GGPL C WVL G++ + CA
Sbjct: 198 HVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCAL 257
Query: 702 SRWPAVFTRVSVFVDWI 718
P V+T V+ + WI
Sbjct: 258 PNRPGVYTSVATYSPWI 274
>gi|4503137 chymotrypsin-like [Homo sapiens]
Length = 264
Score = 124 bits (312), Expect = 2e-28
Identities = 80/237 (33%), Positives = 118/237 (49%), Gaps = 19/237 (8%)
Query: 497 RVVGGHP---GNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLG 553
R+V G G+ PW VSL++ G HFCGGSL+ + W++TA + C++ + V LG
Sbjct: 33 RIVNGENAVLGSWPWQVSLQDSSGFHFCGGSLISQSWVVTA----AHCNVSPGRHFVVLG 88
Query: 554 TLFQNPQHGEPSLQRVPVAKMVCGPS------GSQLVLLKLERSVTLNQRVALICLPPEW 607
+ + EP LQ + V++ + PS + + LLKL R++ +CL
Sbjct: 89 E-YDRSSNAEP-LQVLSVSRAITHPSWNSTTMNNDVTLLKLASPAQYTTRISPVCLASSN 146
Query: 608 YVVPPGTKCEIAGWGETKGTGNDTV--LNVALLNVISNQECNIKHRGRVRESEMCTEGLL 665
+ G C GWG G GN T L L +++ +C + +S +C G
Sbjct: 147 EALTEGLTCVTTGWGRLSGVGNVTPAHLQQVALPLVTVNQCRQYWGSSITDSMICAGG-- 204
Query: 666 APVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVM 722
A +C+GD GGPL C N WVL GI+ R PAV+TRVS F WI++V+
Sbjct: 205 AGASSCQGDSGGPLVCQKGNTWVLIGIVSWGTKNCNVRAPAVYTRVSKFSTWINQVI 261
>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
Length = 275
Score = 124 bits (311), Expect = 3e-28
Identities = 79/252 (31%), Positives = 116/252 (46%), Gaps = 30/252 (11%)
Query: 491 QRRSKLRVVGGHPGNS---PWTVSLR--NRQGQHFCGGSLVKEQWILTARQCFSSCHMPL 545
Q ++ +VGG PW VSLR +R HFCGGSL+ QW+LTA C L
Sbjct: 24 QALQRVGIVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGPDVKDL 83
Query: 546 TGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPS------GSQLVLLKLERSVTLNQRVA 599
V L QH Q +PV++++ P G+ + LL+LE V ++ V
Sbjct: 84 AALRVQL-----REQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVH 138
Query: 600 LICLPPEWYVVPPGTKCEIAGWGETKGTGN---DTVLNVALLNVISNQECNIK-HRGR-- 653
+ LPP PPG C + GWG+ L + ++ N C+ K H G
Sbjct: 139 TVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYT 198
Query: 654 ------VRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAV 707
VR+ +C +C+GD GGPL C + W+ G++ CA+ P +
Sbjct: 199 GDDVRIVRDDMLCAGNTRRD--SCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGI 256
Query: 708 FTRVSVFVDWIH 719
+TRV+ ++DWIH
Sbjct: 257 YTRVTYYLDWIH 268
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 124 bits (310), Expect = 4e-28
Identities = 80/239 (33%), Positives = 119/239 (49%), Gaps = 16/239 (6%)
Query: 497 RVVGGH---PGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLG 553
R+VGG PG PW VSL + Q H CGGS++ +WI+TA C + + G
Sbjct: 292 RIVGGESALPGAWPWQVSL-HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 350
Query: 554 TLFQNPQHGEPSLQRVPVAKMVCGPS------GSQLVLLKLERSVTLNQRVALICLPPEW 607
L Q+ Q V K++ P+ + + L+KL++ +T N V +CLP
Sbjct: 351 ILRQSFMFYGAGYQ---VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPG 407
Query: 608 YVVPPGTKCEIAGWGETKGTGNDT-VLNVALLNVISNQECNIKH--RGRVRESEMCTEGL 664
++ P C I+GWG T+ G + VLN A + +I Q CN ++ + + +C L
Sbjct: 408 MMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFL 467
Query: 665 LAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMR 723
V +C+GD GGPL +N W L G CA++ P V+ V VF DWI++ MR
Sbjct: 468 QGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMR 526
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 124 bits (310), Expect = 4e-28
Identities = 80/239 (33%), Positives = 119/239 (49%), Gaps = 16/239 (6%)
Query: 497 RVVGGH---PGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLG 553
R+VGG PG PW VSL + Q H CGGS++ +WI+TA C + + G
Sbjct: 255 RIVGGESALPGAWPWQVSL-HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAG 313
Query: 554 TLFQNPQHGEPSLQRVPVAKMVCGPS------GSQLVLLKLERSVTLNQRVALICLPPEW 607
L Q+ Q V K++ P+ + + L+KL++ +T N V +CLP
Sbjct: 314 ILRQSFMFYGAGYQ---VEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPG 370
Query: 608 YVVPPGTKCEIAGWGETKGTGNDT-VLNVALLNVISNQECNIKH--RGRVRESEMCTEGL 664
++ P C I+GWG T+ G + VLN A + +I Q CN ++ + + +C L
Sbjct: 371 MMLQPEQLCWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFL 430
Query: 665 LAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHKVMR 723
V +C+GD GGPL +N W L G CA++ P V+ V VF DWI++ MR
Sbjct: 431 QGNVDSCQGDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMR 489
>gi|156938340 transmembrane tryptase preproprotein [Homo sapiens]
Length = 321
Score = 122 bits (306), Expect = 1e-27
Identities = 78/236 (33%), Positives = 116/236 (49%), Gaps = 17/236 (7%)
Query: 497 RVVGGHP---GNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLG 553
R+VGGH G PW SLR R+ H CGGSL+ QW+LTA CFS + + Y+V LG
Sbjct: 37 RIVGGHAAPAGAWPWQASLRLRR-VHVCGGSLLSPQWVLTAAHCFSGS-LNSSDYQVHLG 94
Query: 554 TLFQNPQHGEPSLQRVPVAKMVCGPSGSQ--LVLLKLERSVTLNQRVALICLPPEWYVVP 611
L +++++ + G G+ + L++L VTL+ R+ +CLP
Sbjct: 95 ELEITLSPHFSTVRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCLPEASDDFC 154
Query: 612 PGTKCEIAGWGETKG---TGNDTVLNVALLNVISNQECNIKHRGR----VRESEMCTEGL 664
PG +C + GWG T+ L ++V+ + C + G ++ +C G
Sbjct: 155 PGIRCWVTGWGYTREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARG- 213
Query: 665 LAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIHK 720
P AC+ D GGPL C + WV GI+ C R P V+TRV +V+WI +
Sbjct: 214 --PGDACQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIRR 267
>gi|13775595 tryptase alpha/beta 1 precursor [Homo sapiens]
Length = 275
Score = 121 bits (303), Expect = 3e-27
Identities = 78/252 (30%), Positives = 114/252 (45%), Gaps = 30/252 (11%)
Query: 491 QRRSKLRVVGGHPGNS---PWTVSLR--NRQGQHFCGGSLVKEQWILTARQCFSSCHMPL 545
Q ++ +VGG PW VSLR HFCGGSL+ QW+LTA C L
Sbjct: 24 QALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCGGSLIHPQWVLTAAHCVGPDVKDL 83
Query: 546 TGYEVWLGTLFQNPQHGEPSLQRVPVAKMVCGPS------GSQLVLLKLERSVTLNQRVA 599
V L QH Q +PV++++ P G+ + LL+LE V ++ V
Sbjct: 84 AALRVQL-----REQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVH 138
Query: 600 LICLPPEWYVVPPGTKCEIAGWGETKGTGN---DTVLNVALLNVISNQECNIK-HRGR-- 653
+ LPP PPG C + GWG+ L + ++ N C+ K H G
Sbjct: 139 TVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYT 198
Query: 654 ------VRESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAV 707
VR+ +C +C+GD GGPL C + W+ G++ CA+ P +
Sbjct: 199 GDDVRIVRDDMLCAGNTRRD--SCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGI 256
Query: 708 FTRVSVFVDWIH 719
+TRV+ ++DWIH
Sbjct: 257 YTRVTYYLDWIH 268
>gi|13994276 marapsin [Homo sapiens]
Length = 290
Score = 118 bits (295), Expect = 2e-26
Identities = 77/247 (31%), Positives = 113/247 (45%), Gaps = 25/247 (10%)
Query: 497 RVVGGHP---GNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEVWLG 553
R+VGG G PW VS++ R G HFCGGSL+ EQW+LTA CF + + Y+V LG
Sbjct: 34 RMVGGQDTQEGEWPWQVSIQ-RNGSHFCGGSLIAEQWVLTAAHCFRNTS-ETSLYQVLLG 91
Query: 554 TLFQNPQHGEPSLQRVPVAKMVCGP------SGSQLVLLKLERSVTLNQRVALICLPPEW 607
Q Q G P V ++ P S + + L++LE V + +CLP
Sbjct: 92 AR-QLVQPG-PHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPS 149
Query: 608 YVVPPGTKCEIAGWG---ETKGTGNDTVLNVALLNVISNQECNIKHRG---------RVR 655
+ G C + GWG E +L + +I +CN+ + ++
Sbjct: 150 VIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIK 209
Query: 656 ESEMCTEGLLAPVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFV 715
+C AC+GD GGPL C W+ G+I CAR P V+ RV+
Sbjct: 210 NDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHH 269
Query: 716 DWIHKVM 722
+WIH+++
Sbjct: 270 NWIHRII 276
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 117 bits (294), Expect = 3e-26
Identities = 81/262 (30%), Positives = 122/262 (46%), Gaps = 25/262 (9%)
Query: 480 EKCGKRVDRLDQRRSKLRVVGGHP---GNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQ 536
+ CG+R +D R+VGG G PW VSLR G H CGGSL+ W+LTA
Sbjct: 151 QDCGRRKLPVD------RIVGGRDTSLGRWPWQVSLRY-DGAHLCGGSLLSGDWVLTAAH 203
Query: 537 CFSSCHMPLTGYEVWLGTLFQNPQHG-EPSLQRV-------PVAKMVCGPSGSQLVLLKL 588
CF + L+ + V+ G + Q HG + +Q V P + + + L+ L
Sbjct: 204 CFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHL 263
Query: 589 ERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDT-VLNVALLNVISNQECN 647
+ L + + +CLP + G C + GWG T+ G VL A + +ISN CN
Sbjct: 264 SSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCN 323
Query: 648 IK--HRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNC----WVLEGIIIPNRVCAR 701
+ +++ C + AC+GD GGP C W L GI+ CA
Sbjct: 324 GADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCAL 383
Query: 702 SRWPAVFTRVSVFVDWIHKVMR 723
++ P V+T+VS F +WI + ++
Sbjct: 384 AQKPGVYTKVSDFREWIFQAIK 405
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 117 bits (294), Expect = 3e-26
Identities = 81/262 (30%), Positives = 122/262 (46%), Gaps = 25/262 (9%)
Query: 480 EKCGKRVDRLDQRRSKLRVVGGHP---GNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQ 536
+ CG+R +D R+VGG G PW VSLR G H CGGSL+ W+LTA
Sbjct: 151 QDCGRRKLPVD------RIVGGRDTSLGRWPWQVSLRY-DGAHLCGGSLLSGDWVLTAAH 203
Query: 537 CFSSCHMPLTGYEVWLGTLFQNPQHG-EPSLQRV-------PVAKMVCGPSGSQLVLLKL 588
CF + L+ + V+ G + Q HG + +Q V P + + + L+ L
Sbjct: 204 CFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHL 263
Query: 589 ERSVTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDT-VLNVALLNVISNQECN 647
+ L + + +CLP + G C + GWG T+ G VL A + +ISN CN
Sbjct: 264 SSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCN 323
Query: 648 IK--HRGRVRESEMCTEGLLAPVGACEGDYGGPLACFTHNC----WVLEGIIIPNRVCAR 701
+ +++ C + AC+GD GGP C W L GI+ CA
Sbjct: 324 GADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCAL 383
Query: 702 SRWPAVFTRVSVFVDWIHKVMR 723
++ P V+T+VS F +WI + ++
Sbjct: 384 AQKPGVYTKVSDFREWIFQAIK 405
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 117 bits (294), Expect = 3e-26
Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 12/234 (5%)
Query: 497 RVVGGH---PGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQCFSSCHMP-LTGYEVWL 552
R+VGG PG PW S+ +H CGGS++ +W++TA C S + L+ + V
Sbjct: 217 RIVGGQSVAPGRWPWQASVA-LGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHA 275
Query: 553 GTLFQN---PQHGEPSLQRVPVAKMVCGPSGSQLVLLKLERSVTLNQRVALICLPPEWYV 609
G + + P G + +P + LL+L+ ++ + V +CLP +
Sbjct: 276 GLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQH 335
Query: 610 VPPGTKCEIAGWGET--KGTGNDTVLNVALLNVISNQECNIK--HRGRVRESEMCTEGLL 665
P G++C ++GWG T T + +L ++ + S Q CN + G + +C L
Sbjct: 336 FPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLD 395
Query: 666 APVGACEGDYGGPLACFTHNCWVLEGIIIPNRVCARSRWPAVFTRVSVFVDWIH 719
AC+GD GGPL C + W L G++ R CA P V+ +V+ F+DWIH
Sbjct: 396 GRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIH 449
>gi|15559207 elastase 2A preproprotein [Homo sapiens]
Length = 269
Score = 117 bits (292), Expect = 5e-26
Identities = 88/247 (35%), Positives = 120/247 (48%), Gaps = 29/247 (11%)
Query: 497 RVVGGH---PGNSPWTVSLR---NRQGQHFCGGSLVKEQWILTARQCFSSCHMPLTGYEV 550
RVVGG P + PW VSL+ N + H CGGSL+ W+LTA C SS Y V
Sbjct: 28 RVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVLTAAHCISSSRT----YRV 83
Query: 551 WLGTLFQNPQHGEPSLQRVPVAKMVCGPS--------GSQLVLLKLERSVTLNQRVALIC 602
LG N E V V+K+V G+ + LLKL V+L ++ L C
Sbjct: 84 GLGR--HNLYVAESGSLAVSVSKIVVHKDWNSNQISKGNDIALLKLANPVSLTDKIQLAC 141
Query: 603 LPPEWYVVPPGTKCEIAGWG--ETKGTGNDTVLNVALLNVISNQECNIK--HRGRVRESE 658
LPP ++P C + GWG +T G D VL L V+ C+ V+ S
Sbjct: 142 LPPAGTILPNNYPCYVTGWGRLQTNGAVPD-VLQQGRLLVVDYATCSSSAWWGSSVKTSM 200
Query: 659 MCTEGLLAPVGACEGDYGGPLAC-FTHNCWVLEGII-IPNRV-CARSRWPAVFTRVSVFV 715
+C G + +C GD GGPL C + W + GI+ +R+ C P+VFTRVS ++
Sbjct: 201 ICAGG-DGVISSCNGDSGGPLNCQASDGRWQVHGIVSFGSRLGCNYYHKPSVFTRVSNYI 259
Query: 716 DWIHKVM 722
DWI+ V+
Sbjct: 260 DWINSVI 266
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 116 bits (291), Expect = 6e-26
Identities = 81/253 (32%), Positives = 118/253 (46%), Gaps = 23/253 (9%)
Query: 481 KCGKRVDRLDQRRSKLRVVGG---HPGNSPWTVSLRNRQGQHFCGGSLVKEQWILTARQC 537
+CG D + S+ R++GG G+ PW VSLR H CGGSL+ WILTA C
Sbjct: 172 ECGAGPDLITL--SEQRILGGTEAEEGSWPWQVSLRLNNAHH-CGGSLINNMWILTAAHC 228
Query: 538 FSSCHMPLTGYEVWLGTLFQNPQHGEPSLQRVPVAKMVC------GPSGSQLVLLKLERS 591
F S P W+ T + P L R+ V ++ + + L++LE S
Sbjct: 229 FRSNSNPRD----WIATSGISTTF--PKL-RMRVRNILIHNNYKSATHENDIALVRLENS 281
Query: 592 VTLNQRVALICLPPEWYVVPPGTKCEIAGWGETKGTGNDT-VLNVALLNVISNQECNIKH 650
VT + + +CLP +PPG+ + GWG + G+ L + +ISN CN H
Sbjct: 282 VTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPH 341
Query: 651 --RGRVRESEMCTEGLLAPVGACEGDYGGPLAC-FTHNCWVLEGIIIPNRVCARSRWPAV 707
G + +C V AC+GD GGPL + W + GI+ C P V
Sbjct: 342 SYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGV 401
Query: 708 FTRVSVFVDWIHK 720
+TRV+ ++DWI +
Sbjct: 402 YTRVTAYLDWIRQ 414
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.482
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,393,227
Number of Sequences: 37866
Number of extensions: 1882736
Number of successful extensions: 4124
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 159
Number of HSP's successfully gapped in prelim test: 30
Number of HSP's that attempted gapping in prelim test: 3130
Number of HSP's gapped (non-prelim): 329
length of query: 725
length of database: 18,247,518
effective HSP length: 110
effective length of query: 615
effective length of database: 14,082,258
effective search space: 8660588670
effective search space used: 8660588670
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.