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Search of human proteins with 20336285
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336285 solute carrier family 26, member 8 isoform b [Homo
sapiens]
(865 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336285 solute carrier family 26, member 8 isoform b [Homo s... 1716 0.0
gi|16418457 solute carrier family 26, member 8 isoform a [Homo s... 1299 0.0
gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo s... 234 2e-61
gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo s... 234 2e-61
gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo s... 233 8e-61
gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo s... 211 3e-54
gi|16418413 solute carrier family 26, member 9 isoform a [Homo s... 179 1e-44
gi|217272867 solute carrier family 26, member 9 isoform b [Homo ... 179 1e-44
gi|45827800 prestin isoform b [Homo sapiens] 171 4e-42
gi|39752683 prestin isoform a [Homo sapiens] 171 4e-42
gi|217272870 solute carrier family 26, member 9 isoform c [Homo ... 166 7e-41
gi|4505697 pendrin [Homo sapiens] 163 7e-40
gi|4557535 solute carrier family 26, member 3 [Homo sapiens] 158 2e-38
gi|100913030 solute carrier family 26 member 2 [Homo sapiens] 158 2e-38
gi|47131207 solute carrier family 26, member 1 isoform a [Homo s... 138 3e-32
gi|20336272 solute carrier family 26, member 1 isoform a [Homo s... 138 3e-32
gi|45827802 prestin isoform c [Homo sapiens] 136 1e-31
gi|16306483 solute carrier family 26, member 7 isoform a [Homo s... 100 4e-21
gi|20336282 solute carrier family 26, member 7 isoform b [Homo s... 100 4e-21
gi|65506789 solute carrier family 26, member 10 [Homo sapiens] 91 4e-18
gi|45827804 prestin isoform d [Homo sapiens] 72 2e-12
gi|85540447 solute carrier family 26, member 11 [Homo sapiens] 70 8e-12
gi|20336274 solute carrier family 26, member 1 isoform b [Homo s... 64 8e-10
gi|4505419 nucleolar protein 3 [Homo sapiens] 51 5e-06
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 44 5e-04
gi|21361639 DIPB protein [Homo sapiens] 44 6e-04
gi|83977459 pleckstrin homology-like domain, family A, member 1 ... 44 6e-04
gi|7706589 GNAS complex locus NESP55 [Homo sapiens] 43 0.001
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 43 0.001
gi|196115158 CDKN1A interacting zinc finger protein 1 isoform 4 ... 42 0.002
>gi|20336285 solute carrier family 26, member 8 isoform b [Homo
sapiens]
Length = 865
Score = 1716 bits (4443), Expect = 0.0
Identities = 865/865 (100%), Positives = 865/865 (100%)
Query: 1 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV 60
MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
Sbjct: 1 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV 60
Query: 61 QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL 120
QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
Sbjct: 61 QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL 120
Query: 121 IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN 180
IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN
Sbjct: 121 IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN 180
Query: 181 EFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLL 240
EFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLL
Sbjct: 181 EFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLL 240
Query: 241 PVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSF 300
PVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSF
Sbjct: 241 PVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSF 300
Query: 301 FRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSN 360
FRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSN
Sbjct: 301 FRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSN 360
Query: 361 VIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAK 420
VIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAK
Sbjct: 361 VIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAK 420
Query: 421 ILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPL 480
ILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPL
Sbjct: 421 ILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKEVDMVKVPL 480
Query: 481 KEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCS 540
KEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCS
Sbjct: 481 KEEEIFSLFNSSDTNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCS 540
Query: 541 HFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQG 600
HFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQG
Sbjct: 541 HFESMNTSQTASEDQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQG 600
Query: 601 RRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSI 660
RRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSI
Sbjct: 601 RRSLIPYSDASLLPSVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSI 660
Query: 661 VRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKN 720
VRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKN
Sbjct: 661 VRAFERNDFFDAGITKTQLFLSVHDAVLFALSRKVIGSSELSIDESETVIRETYSETDKN 720
Query: 721 DNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPE 780
DNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPE
Sbjct: 721 DNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPE 780
Query: 781 MEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQT 840
MEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQT
Sbjct: 781 MEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHPSMASTQSQTQT 840
Query: 841 RTWSVERRRHPMDSYSPEGNSNEDV 865
RTWSVERRRHPMDSYSPEGNSNEDV
Sbjct: 841 RTWSVERRRHPMDSYSPEGNSNEDV 865
>gi|16418457 solute carrier family 26, member 8 isoform a [Homo
sapiens]
Length = 970
Score = 1299 bits (3362), Expect = 0.0
Identities = 656/656 (100%), Positives = 656/656 (100%)
Query: 210 IIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIF 269
IIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIF
Sbjct: 315 IIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIF 374
Query: 270 LGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLV 329
LGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLV
Sbjct: 375 LGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLV 434
Query: 330 GAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTF 389
GAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTF
Sbjct: 435 GAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTF 494
Query: 390 SSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVK 449
SSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVK
Sbjct: 495 SSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVK 554
Query: 450 IFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCD 509
IFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCD
Sbjct: 555 IFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKICRCFCNCD 614
Query: 510 DLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQG 569
DLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQG
Sbjct: 615 DLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQG 674
Query: 570 QQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYV 629
QQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYV
Sbjct: 675 QQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHYV 734
Query: 630 DSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLF 689
DSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLF
Sbjct: 735 DSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVLF 794
Query: 690 ALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPV 749
ALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPV
Sbjct: 795 ALSRKVIGSSELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPV 854
Query: 750 EEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNP 809
EEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNP
Sbjct: 855 EEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNP 914
Query: 810 KSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV 865
KSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV
Sbjct: 915 KSRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV 970
Score = 421 bits (1083), Expect = e-117
Identities = 209/211 (99%), Positives = 211/211 (100%)
Query: 1 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV 60
MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV
Sbjct: 1 MAQLERSAISGFSSKSRRNSFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHV 60
Query: 61 QCRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL 120
QCRCSWHRFLRC+LTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL
Sbjct: 61 QCRCSWHRFLRCVLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQL 120
Query: 121 IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN 180
IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN
Sbjct: 121 IPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKN 180
Query: 181 EFSAPSYLMGYNKSLSVVATTTFLTGIIQII 211
EFSAPSYLMGYNKSLSVVATTTFLTGIIQ+I
Sbjct: 181 EFSAPSYLMGYNKSLSVVATTTFLTGIIQLI 211
>gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo
sapiens]
Length = 738
Score = 234 bits (598), Expect = 2e-61
Identities = 172/606 (28%), Positives = 290/606 (47%), Gaps = 65/606 (10%)
Query: 100 ISVGLVQVPQGLT-LSLLARQLIPPLNIAYAAFCSSVIYV-----IFGSCHQMSIGSFFL 153
+ VGL QV GL + L PL Y + ++V +FG G L
Sbjct: 168 VLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSL 227
Query: 154 VSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGF 213
+ +L K+ G +V + L N L ++ +IG
Sbjct: 228 IYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL---NDKLQQQLPMPIPGELLTLIGA 284
Query: 214 TVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKK 273
T I+ + + ++ IP + PV P+ L K++ AF++++V + I LGK
Sbjct: 285 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 344
Query: 274 IASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGV 333
A H Y V+SNQ+L+A+GL N++ F+ + +++R+++Q+ +GG Q A + +
Sbjct: 345 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 404
Query: 334 MLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSI 393
+LL++VK+G F+ LP AVLA II+ N+ L +S++ SLW+ ++ D +W++TF+++I
Sbjct: 405 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 464
Query: 394 FLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQC 453
L LD+GL+++V+ + + VR+ +LGQ+P+T+IYR + +Y E + GVK+F+
Sbjct: 465 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 524
Query: 454 CSSITFVNVYY----LKHKLLKEVDMV----KVPLKEEEIFSLFNSSDTNLQGGKICRCF 505
+++ F N + LK + +VD + K LK++E L LQ + R
Sbjct: 525 SATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKL-----KQLQKEEKLR-- 577
Query: 506 CNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQ 565
+ P+ +S+++ + E M ++ ED VSS
Sbjct: 578 ------------------KQAASPKGASVSINVNTSLEDMRSNNV--EDCKMMQVSS-GD 616
Query: 566 KNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSM 625
K + E+ P+ S+ + GLP P H++ILD
Sbjct: 617 KMEDATANGQEDSKAPDGSTLKAL-GLPQ-------------------PDFHSLILDLGA 656
Query: 626 VHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHD 685
+ +VD+ L L+ I + F+ + + +A CHS +V E FFDA ITK LF SVHD
Sbjct: 657 LSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHD 716
Query: 686 AVLFAL 691
AV FAL
Sbjct: 717 AVTFAL 722
Score = 84.0 bits (206), Expect = 6e-16
Identities = 49/140 (35%), Positives = 80/140 (57%), Gaps = 7/140 (5%)
Query: 24 DVKREVYNEET--FQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPFLE 81
D++R Y+ E QEH + G+ T + +CS R +L P L
Sbjct: 2 DLRRRDYHMERPLLNQEHLEELGRWGSAP---RTHQWRTWLQCSRARAYALLLQHLPVLV 58
Query: 82 WMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIFG 141
W+ Y ++DWLLGDLL+G+SV ++Q+PQGL +LLA +PP+ Y++F IY +FG
Sbjct: 59 WLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFLFG 116
Query: 142 SCHQMSIGSFFLVSALLINV 161
+ +S+G+F ++S ++ +V
Sbjct: 117 TSRHISVGTFAVMSVMVGSV 136
>gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo
sapiens]
Length = 759
Score = 234 bits (598), Expect = 2e-61
Identities = 172/606 (28%), Positives = 290/606 (47%), Gaps = 65/606 (10%)
Query: 100 ISVGLVQVPQGLT-LSLLARQLIPPLNIAYAAFCSSVIYV-----IFGSCHQMSIGSFFL 153
+ VGL QV GL + L PL Y + ++V +FG G L
Sbjct: 189 VLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSL 248
Query: 154 VSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGF 213
+ +L K+ G +V + L N L ++ +IG
Sbjct: 249 IYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL---NDKLQQQLPMPIPGELLTLIGA 305
Query: 214 TVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKK 273
T I+ + + ++ IP + PV P+ L K++ AF++++V + I LGK
Sbjct: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
Query: 274 IASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGV 333
A H Y V+SNQ+L+A+GL N++ F+ + +++R+++Q+ +GG Q A + +
Sbjct: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
Query: 334 MLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSI 393
+LL++VK+G F+ LP AVLA II+ N+ L +S++ SLW+ ++ D +W++TF+++I
Sbjct: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
Query: 394 FLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQC 453
L LD+GL+++V+ + + VR+ +LGQ+P+T+IYR + +Y E + GVK+F+
Sbjct: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
Query: 454 CSSITFVNVYY----LKHKLLKEVDMV----KVPLKEEEIFSLFNSSDTNLQGGKICRCF 505
+++ F N + LK + +VD + K LK++E L LQ + R
Sbjct: 546 SATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKL-----KQLQKEEKLR-- 598
Query: 506 CNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQ 565
+ P+ +S+++ + E M ++ ED VSS
Sbjct: 599 ------------------KQAASPKGASVSINVNTSLEDMRSNNV--EDCKMMQVSS-GD 637
Query: 566 KNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSM 625
K + E+ P+ S+ + GLP P H++ILD
Sbjct: 638 KMEDATANGQEDSKAPDGSTLKAL-GLPQ-------------------PDFHSLILDLGA 677
Query: 626 VHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHD 685
+ +VD+ L L+ I + F+ + + +A CHS +V E FFDA ITK LF SVHD
Sbjct: 678 LSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHD 737
Query: 686 AVLFAL 691
AV FAL
Sbjct: 738 AVTFAL 743
Score = 85.1 bits (209), Expect = 3e-16
Identities = 50/142 (35%), Positives = 81/142 (57%), Gaps = 7/142 (4%)
Query: 22 AYDVKREVYNEET--FQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPF 79
A D++R Y+ E QEH + G+ T + +CS R +L P
Sbjct: 21 AMDLRRRDYHMERPLLNQEHLEELGRWGSAP---RTHQWRTWLQCSRARAYALLLQHLPV 77
Query: 80 LEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVI 139
L W+ Y ++DWLLGDLL+G+SV ++Q+PQGL +LLA +PP+ Y++F IY +
Sbjct: 78 LVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFL 135
Query: 140 FGSCHQMSIGSFFLVSALLINV 161
FG+ +S+G+F ++S ++ +V
Sbjct: 136 FGTSRHISVGTFAVMSVMVGSV 157
>gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo
sapiens]
Length = 758
Score = 233 bits (593), Expect = 8e-61
Identities = 170/606 (28%), Positives = 289/606 (47%), Gaps = 66/606 (10%)
Query: 100 ISVGLVQVPQGLT-LSLLARQLIPPLNIAYAAFCSSVIYV-----IFGSCHQMSIGSFFL 153
+ VGL QV GL + L PL Y + ++V +FG G L
Sbjct: 189 VLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSL 248
Query: 154 VSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGF 213
+ +L K+ G +V + L N L ++ +IG
Sbjct: 249 IYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL---NDKLQQQLPMPIPGELLTLIGA 305
Query: 214 TVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKK 273
T I+ + + ++ IP + PV P+ L K++ AF++++V + I LGK
Sbjct: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
Query: 274 IASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGV 333
A H Y V+SNQ+L+A+GL N++ F+ + +++R+++Q+ +GG Q A + +
Sbjct: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
Query: 334 MLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSI 393
+LL++VK+G F+ LP AVLA II+ N+ L +S++ SLW+ ++ D +W++TF+++I
Sbjct: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
Query: 394 FLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQC 453
L LD+GL+++V+ + + VR+ +LGQ+P+T+IYR + +Y E + GVK+F+
Sbjct: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
Query: 454 CSSITFVNVYY----LKHKLLKEVDMV----KVPLKEEEIFSLFNSSDTNLQGGKICRCF 505
+++ F N + LK + +VD + K LK++E L LQ + R
Sbjct: 546 SATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKL-----KQLQKEEKLR-- 598
Query: 506 CNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQ 565
+ P+ +S+++ + E M ++ + VSS
Sbjct: 599 ------------------KQAASPKGASVSINVNTSLEDMRSNNV---EDCKMMVSS-GD 636
Query: 566 KNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSM 625
K + E+ P+ S+ + GLP P H++ILD
Sbjct: 637 KMEDATANGQEDSKAPDGSTLKAL-GLPQ-------------------PDFHSLILDLGA 676
Query: 626 VHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHD 685
+ +VD+ L L+ I + F+ + + +A CHS +V E FFDA ITK LF SVHD
Sbjct: 677 LSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHD 736
Query: 686 AVLFAL 691
AV FAL
Sbjct: 737 AVTFAL 742
Score = 85.1 bits (209), Expect = 3e-16
Identities = 50/142 (35%), Positives = 81/142 (57%), Gaps = 7/142 (4%)
Query: 22 AYDVKREVYNEET--FQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPF 79
A D++R Y+ E QEH + G+ T + +CS R +L P
Sbjct: 21 AMDLRRRDYHMERPLLNQEHLEELGRWGSAP---RTHQWRTWLQCSRARAYALLLQHLPV 77
Query: 80 LEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVI 139
L W+ Y ++DWLLGDLL+G+SV ++Q+PQGL +LLA +PP+ Y++F IY +
Sbjct: 78 LVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFL 135
Query: 140 FGSCHQMSIGSFFLVSALLINV 161
FG+ +S+G+F ++S ++ +V
Sbjct: 136 FGTSRHISVGTFAVMSVMVGSV 157
>gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo
sapiens]
Length = 740
Score = 211 bits (536), Expect = 3e-54
Identities = 163/606 (26%), Positives = 276/606 (45%), Gaps = 84/606 (13%)
Query: 100 ISVGLVQVPQGLT-LSLLARQLIPPLNIAYAAFCSSVIYV-----IFGSCHQMSIGSFFL 153
+ VGL QV GL + L PL Y + ++V +FG G L
Sbjct: 189 VLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSL 248
Query: 154 VSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQIIGF 213
+ +L K+ G +V + L N L ++ +IG
Sbjct: 249 IYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLL---NDKLQQQLPMPIPGELLTLIGA 305
Query: 214 TVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKK 273
T I+ + + ++ IP + PV P+ L K++ AF++++V + I LGK
Sbjct: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
Query: 274 IASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGV 333
A H Y V+SNQ+L+A+GL N++ F+ + +++R+++Q+ +GG Q A + +
Sbjct: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
Query: 334 MLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSI 393
+LL++VK+G F+ LP AVLA II+ N+ L +S++ SLW+ ++ D +W++TF+++I
Sbjct: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
Query: 394 FLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQC 453
L LD+GL+++V+ + + VR+ +LGQ+P+T+IYR + +Y E + GVK+F+
Sbjct: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
Query: 454 CSSITFVNVYY----LKHKLLKEVDMV----KVPLKEEEIFSLFNSSDTNLQGGKICRCF 505
+++ F N + LK + +VD + K LK++E L LQ
Sbjct: 546 SATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKL-----KQLQK------- 593
Query: 506 CNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQ 565
E KL +A + L C + Q +S D++ ++ +
Sbjct: 594 ------------------EEKLRKQAGPL-LSAC-----LAPQQVSSGDKMEDATANGQE 629
Query: 566 KNQGQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSM 625
++ ++ + LP PD + + D L S+ I DF
Sbjct: 630 DSKAPDGSTLKALGLPQ----------PDFHSLILDLGALSFVDTVCLKSLKNIFHDF-- 677
Query: 626 VHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHD 685
+ + + +A CHS +V E FFDA ITK LF SVHD
Sbjct: 678 -------------------REIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHD 718
Query: 686 AVLFAL 691
AV FAL
Sbjct: 719 AVTFAL 724
Score = 85.1 bits (209), Expect = 3e-16
Identities = 50/142 (35%), Positives = 81/142 (57%), Gaps = 7/142 (4%)
Query: 22 AYDVKREVYNEET--FQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPF 79
A D++R Y+ E QEH + G+ T + +CS R +L P
Sbjct: 21 AMDLRRRDYHMERPLLNQEHLEELGRWGSAP---RTHQWRTWLQCSRARAYALLLQHLPV 77
Query: 80 LEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVI 139
L W+ Y ++DWLLGDLL+G+SV ++Q+PQGL +LLA +PP+ Y++F IY +
Sbjct: 78 LVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAG--LPPVFGLYSSFYPVFIYFL 135
Query: 140 FGSCHQMSIGSFFLVSALLINV 161
FG+ +S+G+F ++S ++ +V
Sbjct: 136 FGTSRHISVGTFAVMSVMVGSV 157
>gi|16418413 solute carrier family 26, member 9 isoform a [Homo
sapiens]
Length = 791
Score = 179 bits (453), Expect = 1e-44
Identities = 139/524 (26%), Positives = 246/524 (46%), Gaps = 57/524 (10%)
Query: 205 TGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSS 264
T +I ++ T I+ M + ++ I F PV+P S +I AFSL++VS
Sbjct: 286 TEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSY 345
Query: 265 FLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQ 324
+ + +G+ +A+ H Y V+SNQ++IA+G N SFF+ V A++ T+ D +GG+ Q
Sbjct: 346 VINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQ 405
Query: 325 FASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCAL 384
ASL + V+++ M+ +G + Y LP +VL +I N+ L+ +++ LWR+ + DC +
Sbjct: 406 VASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCI 465
Query: 385 WMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIIT 444
W+++F SS FL L G+ + V + + ++ L Q+ +T+IY + Y
Sbjct: 466 WVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQD 525
Query: 445 IPGVKIFQCCSSITFVNVYYLKHKLLKE--VDMVKVPLKEEEIFSLFNSSDTNLQGGKIC 502
I G+KI CS + F N + K++ + +D KV L +++
Sbjct: 526 IQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLK--------------- 570
Query: 503 RCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSS 562
++ + ++ P +L + S+ Q E+ P ++
Sbjct: 571 ------------------KQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNN 612
Query: 563 VSQKNQGQQYEEVEEVWLPNNSS-RNSSPGLPDVAESQGRRSLIPYSDASLLPSV--HTI 619
G + + P++SS S P P AE+ G S + AS+ P V HT+
Sbjct: 613 NQTPANGTSVSYI--TFSPDSSSPAQSEP--PASAEAPGEPSDML---ASVPPFVTFHTL 665
Query: 620 ILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQ- 678
ILD S V +VD G+ L ++ + + + + + H+ + F+ G + +
Sbjct: 666 ILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKH 725
Query: 679 LFLSVHDAVLFALS-----------RKVIGSSELSIDESETVIR 711
+F S+HDAVLFA + + G +ELS+ +SE IR
Sbjct: 726 VFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIR 769
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/192 (32%), Positives = 98/192 (51%), Gaps = 17/192 (8%)
Query: 63 RCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIP 122
RCS + + + P L W+ Y++KD+++ DLL G+S G +QVPQG+ +LLA +P
Sbjct: 42 RCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLAN--LP 99
Query: 123 PLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINV-LKVSPFNNGQLVMGSFVKNE 181
+N Y++F + Y G HQM G+F ++S L+ N+ L+++P + Q+ + NE
Sbjct: 100 AVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNA--TNE 157
Query: 182 FSAPSYLMGYNKSLSVVATTTFLTGIIQI------IGFTVIANKIS-----MATETSQTL 230
+ M + L V AT LT IIQ+ GF I S M Q L
Sbjct: 158 SYVDTAAMEAER-LHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQIL 216
Query: 231 IDMIPYSFLLPV 242
I ++ Y F L +
Sbjct: 217 ISVLKYIFGLTI 228
>gi|217272867 solute carrier family 26, member 9 isoform b [Homo
sapiens]
Length = 887
Score = 179 bits (453), Expect = 1e-44
Identities = 139/524 (26%), Positives = 246/524 (46%), Gaps = 57/524 (10%)
Query: 205 TGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSS 264
T +I ++ T I+ M + ++ I F PV+P S +I AFSL++VS
Sbjct: 286 TEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSY 345
Query: 265 FLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQ 324
+ + +G+ +A+ H Y V+SNQ++IA+G N SFF+ V A++ T+ D +GG+ Q
Sbjct: 346 VINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQ 405
Query: 325 FASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCAL 384
ASL + V+++ M+ +G + Y LP +VL +I N+ L+ +++ LWR+ + DC +
Sbjct: 406 VASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCI 465
Query: 385 WMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIIT 444
W+++F SS FL L G+ + V + + ++ L Q+ +T+IY + Y
Sbjct: 466 WVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQD 525
Query: 445 IPGVKIFQCCSSITFVNVYYLKHKLLKE--VDMVKVPLKEEEIFSLFNSSDTNLQGGKIC 502
I G+KI CS + F N + K++ + +D KV L +++
Sbjct: 526 IQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLK--------------- 570
Query: 503 RCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSS 562
++ + ++ P +L + S+ Q E+ P ++
Sbjct: 571 ------------------KQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNN 612
Query: 563 VSQKNQGQQYEEVEEVWLPNNSS-RNSSPGLPDVAESQGRRSLIPYSDASLLPSV--HTI 619
G + + P++SS S P P AE+ G S + AS+ P V HT+
Sbjct: 613 NQTPANGTSVSYI--TFSPDSSSPAQSEP--PASAEAPGEPSDML---ASVPPFVTFHTL 665
Query: 620 ILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQ- 678
ILD S V +VD G+ L ++ + + + + + H+ + F+ G + +
Sbjct: 666 ILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKH 725
Query: 679 LFLSVHDAVLFALS-----------RKVIGSSELSIDESETVIR 711
+F S+HDAVLFA + + G +ELS+ +SE IR
Sbjct: 726 VFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIR 769
Score = 85.5 bits (210), Expect = 2e-16
Identities = 63/192 (32%), Positives = 98/192 (51%), Gaps = 17/192 (8%)
Query: 63 RCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIP 122
RCS + + + P L W+ Y++KD+++ DLL G+S G +QVPQG+ +LLA +P
Sbjct: 42 RCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLAN--LP 99
Query: 123 PLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINV-LKVSPFNNGQLVMGSFVKNE 181
+N Y++F + Y G HQM G+F ++S L+ N+ L+++P + Q+ + NE
Sbjct: 100 AVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNA--TNE 157
Query: 182 FSAPSYLMGYNKSLSVVATTTFLTGIIQI------IGFTVIANKIS-----MATETSQTL 230
+ M + L V AT LT IIQ+ GF I S M Q L
Sbjct: 158 SYVDTAAMEAER-LHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQIL 216
Query: 231 IDMIPYSFLLPV 242
I ++ Y F L +
Sbjct: 217 ISVLKYIFGLTI 228
>gi|45827800 prestin isoform b [Homo sapiens]
Length = 685
Score = 171 bits (432), Expect = 4e-42
Identities = 81/232 (34%), Positives = 141/232 (60%)
Query: 230 LIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLI 289
++ +P L P PD SL + + A ++++V + I + K +A+ H Y V+ NQ+LI
Sbjct: 317 VVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELI 376
Query: 290 AIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLP 349
A+GLCN + S F++ + +++R+++Q+ +GG+ Q A + + ++LL+++ G F +LP
Sbjct: 377 ALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLP 436
Query: 350 NAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAF 409
AVL+ I++ N+ S+LP WR + + +W+ TF SS+FLGLD GLI +V+ A
Sbjct: 437 QAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIAL 496
Query: 410 FITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVN 461
R+ +LG++P T++Y I+ Y E+ IPG+KIFQ + I + N
Sbjct: 497 LTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYAN 548
Score = 72.4 bits (176), Expect = 2e-12
Identities = 45/147 (30%), Positives = 79/147 (53%), Gaps = 9/147 (6%)
Query: 64 CSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPP 123
C+ + + P +W+ Y+ K+++LGDL++GIS G++Q+PQGL ++LA +PP
Sbjct: 52 CTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLA--AVPP 109
Query: 124 LNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSF-VKNEF 182
+ Y++F ++Y G+ +SIG F ++S L+I + V + ++ G N
Sbjct: 110 IFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIGGVAVRLVPDDIVIPGGVNATNGT 168
Query: 183 SAPSYLMGYNKSLSVVATTTFLTGIIQ 209
A L + V + T L+GIIQ
Sbjct: 169 EARDAL-----RVKVAMSVTLLSGIIQ 190
Score = 43.5 bits (101), Expect = 8e-04
Identities = 19/48 (39%), Positives = 31/48 (64%)
Query: 615 SVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVR 662
+VHT+ILDF+ V+++DS G+ L I + + I + +AGC + I R
Sbjct: 638 NVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAFIQR 685
>gi|39752683 prestin isoform a [Homo sapiens]
Length = 744
Score = 171 bits (432), Expect = 4e-42
Identities = 81/232 (34%), Positives = 141/232 (60%)
Query: 230 LIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLI 289
++ +P L P PD SL + + A ++++V + I + K +A+ H Y V+ NQ+LI
Sbjct: 317 VVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELI 376
Query: 290 AIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLP 349
A+GLCN + S F++ + +++R+++Q+ +GG+ Q A + + ++LL+++ G F +LP
Sbjct: 377 ALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLP 436
Query: 350 NAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAF 409
AVL+ I++ N+ S+LP WR + + +W+ TF SS+FLGLD GLI +V+ A
Sbjct: 437 QAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIAL 496
Query: 410 FITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVN 461
R+ +LG++P T++Y I+ Y E+ IPG+KIFQ + I + N
Sbjct: 497 LTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINAPIYYAN 548
Score = 72.4 bits (176), Expect = 2e-12
Identities = 45/147 (30%), Positives = 79/147 (53%), Gaps = 9/147 (6%)
Query: 64 CSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPP 123
C+ + + P +W+ Y+ K+++LGDL++GIS G++Q+PQGL ++LA +PP
Sbjct: 52 CTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLA--AVPP 109
Query: 124 LNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSF-VKNEF 182
+ Y++F ++Y G+ +SIG F ++S L+I + V + ++ G N
Sbjct: 110 IFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIGGVAVRLVPDDIVIPGGVNATNGT 168
Query: 183 SAPSYLMGYNKSLSVVATTTFLTGIIQ 209
A L + V + T L+GIIQ
Sbjct: 169 EARDAL-----RVKVAMSVTLLSGIIQ 190
Score = 67.8 bits (164), Expect = 4e-11
Identities = 34/93 (36%), Positives = 53/93 (56%)
Query: 615 SVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGI 674
+VHT+ILDF+ V+++DS G+ L I + + I + +AGC + +V RN FF+
Sbjct: 638 NVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVVNDLTRNRFFENPA 697
Query: 675 TKTQLFLSVHDAVLFALSRKVIGSSELSIDESE 707
LF S+HDAVL + R+ + E S S+
Sbjct: 698 LWELLFHSIHDAVLGSQLREALAEQEASAPPSQ 730
>gi|217272870 solute carrier family 26, member 9 isoform c [Homo
sapiens]
Length = 459
Score = 166 bits (421), Expect = 7e-41
Identities = 127/473 (26%), Positives = 225/473 (47%), Gaps = 57/473 (12%)
Query: 256 AFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTII 315
AFSL++VS + + +G+ +A+ H Y V+SNQ++IA+G N SFF+ V A++ T+
Sbjct: 5 AFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLA 64
Query: 316 QDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLW 375
D +GG+ Q ASL + V+++ M+ +G + Y LP +VL +I N+ L+ +++ LW
Sbjct: 65 VDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLW 124
Query: 376 RQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRS 435
R+ + DC +W+++F SS FL L G+ + V + + ++ L Q+ +T+IY +
Sbjct: 125 RKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVN 184
Query: 436 INDYREIITIPGVKIFQCCSSITFVNVYYLKHKLLKE--VDMVKVPLKEEEIFSLFNSSD 493
Y I G+KI CS + F N + K++ + +D KV L +++
Sbjct: 185 PKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLK------ 238
Query: 494 TNLQGGKICRCFCNCDDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASE 553
++ + ++ P +L + S+ Q E
Sbjct: 239 ---------------------------KQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFE 271
Query: 554 DQVPYTVSSVSQKNQGQQYEEVEEVWLPNNSS-RNSSPGLPDVAESQGRRSLIPYSDASL 612
+ P ++ G + + P++SS S P P AE+ G S + AS+
Sbjct: 272 NAPPTDPNNNQTPANGTSVSYI--TFSPDSSSPAQSEP--PASAEAPGEPSDML---ASV 324
Query: 613 LPSV--HTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFF 670
P V HT+ILD S V +VD G+ L ++ + + + + + H+ + F
Sbjct: 325 PPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVF 384
Query: 671 DAGITKTQ-LFLSVHDAVLFALS-----------RKVIGSSELSIDESETVIR 711
+ G + + +F S+HDAVLFA + + G +ELS+ +SE IR
Sbjct: 385 EDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIR 437
>gi|4505697 pendrin [Homo sapiens]
Length = 780
Score = 163 bits (412), Expect = 7e-40
Identities = 125/504 (24%), Positives = 231/504 (45%), Gaps = 64/504 (12%)
Query: 214 TVIANKISMATETSQT----LIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIF 269
T+IA IS + ++ IP FL P P SL +++ +FS+++V+ + +
Sbjct: 307 TIIATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVS 366
Query: 270 LGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLV 329
+GK A+ ++Y+++ NQ+ IA G+ N+ S FF V T A++RT +Q+ +GG+ Q A ++
Sbjct: 367 VGKVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGII 426
Query: 330 GAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTF 389
A ++++ ++ +G L +VLA ++++N+ + ++P LWRQ++ D +W+ T
Sbjct: 427 SAAIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTC 486
Query: 390 SSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVK 449
SI LGLD+GL+ ++ F + TV +L Q P+ N SI P
Sbjct: 487 IVSIILGLDLGLLAGLI--FGLLTV-------VLRVQFPSWNGLGSI---------PSTD 528
Query: 450 IFQCCSSITFVNVYYLKHKLLKEVDMVKVPLKEEEIFSLFNSSDTNLQGGKIC-RCFCNC 508
I++ + +K ++E VK+ IF N+ G K C +
Sbjct: 529 IYKSTKN----------YKNIEEPQGVKILRFSSPIFY------GNVDGFKKCIKSTVGF 572
Query: 509 DDLEPLPRILYTERFENKLDPEASSINLIHCSHFESMNTSQTASEDQVPYTVSSVSQKNQ 568
D + + L R KL + + VS+ +
Sbjct: 573 DAIRVYNKRLKALRKIQKLIKSGQL---------------RATKNGIISDAVSTNNAFEP 617
Query: 569 GQQYEEVEEVWLPNNSSRNSSPGLPDVAESQGRRSLIPYSDASLLPSVHTIILDFSMVHY 628
+ E++EE+ +P ++ S +P +H+++LD + +
Sbjct: 618 DEDIEDLEELDIPTK----------EIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISF 667
Query: 629 VDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGITKTQLFLSVHDAVL 688
+D G+ LR I FQ ++ + A ++ E+ FFD I K FL+VHDA+L
Sbjct: 668 LDVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAIL 727
Query: 689 FALSRKVIGSSELSIDESETVIRE 712
+ ++ + SI E+ T+I++
Sbjct: 728 YLQNQVKSQEGQGSILETITLIQD 751
Score = 97.1 bits (240), Expect = 6e-20
Identities = 63/200 (31%), Positives = 105/200 (52%), Gaps = 22/200 (11%)
Query: 20 SFAYDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQCRCSWHRFLRCMLTIFPF 79
S +Y V R VY+E FQQ+H+R+ + ++ C CS R + T+ P
Sbjct: 17 SCSYMVSRPVYSELAFQQQHERRLQERKTLRESLAKC-----CSCSRKRAFGVLKTLVPI 71
Query: 80 LEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVI 139
LEW+ YR+K+WLL D+++G+S GLV QG+ +LLA +P Y+AF + Y I
Sbjct: 72 LEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLA--AVPVGYGLYSAFFPILTYFI 129
Query: 140 FGSCHQMSIGSFFLVSALLIN-VLKVSP-------FNNGQLVMGSFVKNEFSAPSYLMGY 191
FG+ +S+G F +VS ++ + VL ++P +NG ++ + + + ++
Sbjct: 130 FGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVL-- 187
Query: 192 NKSLSVVATTTFLTGIIQII 211
+ + T L GIIQ+I
Sbjct: 188 -----IASALTLLVGIIQLI 202
>gi|4557535 solute carrier family 26, member 3 [Homo sapiens]
Length = 764
Score = 158 bits (400), Expect = 2e-38
Identities = 87/243 (35%), Positives = 139/243 (57%), Gaps = 3/243 (1%)
Query: 232 DMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASL-HNYSVNSNQDLIA 290
DM P F P+TPD + F +++V+ F + F + SL ++Y ++ NQ+LIA
Sbjct: 320 DMNP-GFQPPITPDVETFQNTVGDCFGIAMVA-FAVAFSVASVYSLKYDYPLDGNQELIA 377
Query: 291 IGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLPN 350
+GL N+V FR + A++R+ +Q+ +GG+ Q A L+GA ++L++++ +G L
Sbjct: 378 LGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQK 437
Query: 351 AVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAFF 410
+VLA + L N+ L + + LWR+D+YDC +W+MTF +I LGL +GL SV
Sbjct: 438 SVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLL 497
Query: 411 ITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIFQCCSSITFVNVYYLKHKLL 470
R+ K L I TNIY++ DY ++ GVKIF+C S I F N+ + + KL+
Sbjct: 498 TIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLI 557
Query: 471 KEV 473
V
Sbjct: 558 DAV 560
Score = 105 bits (263), Expect = 1e-22
Identities = 72/207 (34%), Positives = 108/207 (52%), Gaps = 25/207 (12%)
Query: 23 YDVKREVYNEETFQQEHKRKASSSGNMNINITTFRHHVQ--CRCSWHRFLRCMLTIFPFL 80
Y V R VY+ F++ HK+ TF H++ C CS + R +L++FP
Sbjct: 9 YIVARPVYSTNAFEENHKKTGRHH-------KTFLDHLKVCCSCSPQKAKRIVLSLFPIA 61
Query: 81 EWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIYVIF 140
W+ YRLK+WLL D+++GIS G+V V QGL +LL IPP+ YA+F ++IY+ F
Sbjct: 62 SWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVD--IPPVYGLYASFFPAIIYLFF 119
Query: 141 GSCHQMSIGSFFLVS-----ALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSL 195
G+ +S+G F ++S A+ V K P N + + N + S L +
Sbjct: 120 GTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTL---GLPNNSNNSSLLDDERVRV 176
Query: 196 SVVATTTFLTGIIQI------IGFTVI 216
+ A+ T L+GIIQ+ IGF VI
Sbjct: 177 AAAASVTVLSGIIQLAFGILRIGFVVI 203
Score = 57.4 bits (137), Expect = 6e-08
Identities = 28/88 (31%), Positives = 47/88 (53%)
Query: 615 SVHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGI 674
S+H++ILDFS V ++D + L+ I F + + I G + R +FFD +
Sbjct: 645 SLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEV 704
Query: 675 TKTQLFLSVHDAVLFALSRKVIGSSELS 702
+ FL++HDAVL L +K +S+ +
Sbjct: 705 KSSIFFLTIHDAVLHILMKKDYSTSKFN 732
>gi|100913030 solute carrier family 26 member 2 [Homo sapiens]
Length = 739
Score = 158 bits (399), Expect = 2e-38
Identities = 73/266 (27%), Positives = 150/266 (56%)
Query: 207 IIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFL 266
++ ++ T+ ++ + + ++ IP F+ P P+++L+P + + A ++S++ +
Sbjct: 337 LVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISIIGFAI 396
Query: 267 LIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFA 326
+ L + A H Y+V +NQ++ AIG CN++ SFF + A+A+T++++ +G Q +
Sbjct: 397 TVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCHTQLS 456
Query: 327 SLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWM 386
+V A V+LL+++ + FY+L +VL I + N+ L +LP +W + D +W
Sbjct: 457 GVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDTVIWF 516
Query: 387 MTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIP 446
+T SS L +IGL++ V + F +R+ + K LLG + + ++ S++ Y+ + P
Sbjct: 517 VTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNLQIKP 576
Query: 447 GVKIFQCCSSITFVNVYYLKHKLLKE 472
G+KIF+ + + ++N K L K+
Sbjct: 577 GIKIFRFVAPLYYINKECFKSALYKQ 602
Score = 71.6 bits (174), Expect = 3e-12
Identities = 52/170 (30%), Positives = 85/170 (50%), Gaps = 27/170 (15%)
Query: 62 CRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLI 121
C+CS + +L P L+W+ Y LK +LGD+++G+ VG++ VPQ + SLLA Q
Sbjct: 78 CQCSPAKAKNMILGFLPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQ-- 135
Query: 122 PPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNE 181
P+ Y +F +S+IY + G+ +S+G F ++ L + + +L + N
Sbjct: 136 EPVYGLYTSFFASIIYFLLGTSRHISVGIFGVL------CLMIGETVDRELQKAGY-DNA 188
Query: 182 FSAPSYLMGYNKS-----------------LSVVATTTFLTGIIQI-IGF 213
SAPS M N S + V +T TF+ G+ Q+ +GF
Sbjct: 189 HSAPSLGMVSNGSTLLNHTSDRICDKSCYAIMVGSTVTFIAGVYQVAMGF 238
Score = 42.0 bits (97), Expect = 0.002
Identities = 22/75 (29%), Positives = 44/75 (58%), Gaps = 1/75 (1%)
Query: 616 VHTIILDFSMVHYVDSRGLVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFDAGIT 675
+HTI++D S + ++D+ G+ L+++ ++ I +L+A C+ + VR N +
Sbjct: 646 LHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQCNPT-VRDSLTNGEYCKKEE 704
Query: 676 KTQLFLSVHDAVLFA 690
+ LF SV++A+ FA
Sbjct: 705 ENLLFYSVYEAMAFA 719
>gi|47131207 solute carrier family 26, member 1 isoform a [Homo
sapiens]
Length = 701
Score = 138 bits (347), Expect = 3e-32
Identities = 71/257 (27%), Positives = 142/257 (55%)
Query: 205 TGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSS 264
T ++ I+ T++++ + ++ IP F+ P P+ L+ ++ L A +L+LV++
Sbjct: 294 TELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVALALVAA 353
Query: 265 FLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQ 324
I L + A H YSV +NQ+L+A+G CNV+ +F + A+A+++++ +G R Q
Sbjct: 354 AFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQ 413
Query: 325 FASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCAL 384
+S+V A V+LL+++ + F+ L +VLA +I+ ++ L + +LP LWR D +
Sbjct: 414 LSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALV 473
Query: 385 WMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIIT 444
W T ++ + + + GL+ V+ + R+ R + LL +I +T Y ++ ++
Sbjct: 474 WAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVP 533
Query: 445 IPGVKIFQCCSSITFVN 461
PGV++F+ + + N
Sbjct: 534 EPGVRVFRFGGPLYYAN 550
Score = 65.5 bits (158), Expect = 2e-10
Identities = 40/164 (24%), Positives = 77/164 (46%), Gaps = 22/164 (13%)
Query: 62 CRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLI 121
C CS + + P W+ YR +++L GD+++G+ +G++ VPQ + SLLA +
Sbjct: 39 CSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAG--L 96
Query: 122 PPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK--------------VSPF 167
P+ Y +F +++IY + G+ +S+G F L+ ++ V+ + P
Sbjct: 97 QPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPG 156
Query: 168 NNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQII 211
N + GS + Y ++ V T +TG+ Q++
Sbjct: 157 ANSSTLNGSAAMLDCGRDCY------AIRVATALTLMTGLYQVL 194
Score = 46.6 bits (109), Expect = 1e-04
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 9/114 (7%)
Query: 588 SSPGLPDVAESQGRRSLIPYSD-ASLLPSV---HTIILDFSMVHYVDSRGLVVLRQICNA 643
S G+ + +QG L P S A+L+P+ HT+++D + + ++D+ G+ L+ +
Sbjct: 578 SETGVGEGGPAQGE-DLGPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRD 636
Query: 644 FQNANILILIAGCHSSIVRAFERNDFFDAGITKT----QLFLSVHDAVLFALSR 693
+ I +L+A C + R F G T QLFLSVHDAV A +R
Sbjct: 637 YGALGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARAR 690
>gi|20336272 solute carrier family 26, member 1 isoform a [Homo
sapiens]
Length = 701
Score = 138 bits (347), Expect = 3e-32
Identities = 71/257 (27%), Positives = 142/257 (55%)
Query: 205 TGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSS 264
T ++ I+ T++++ + ++ IP F+ P P+ L+ ++ L A +L+LV++
Sbjct: 294 TELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVALALVAA 353
Query: 265 FLLIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQ 324
I L + A H YSV +NQ+L+A+G CNV+ +F + A+A+++++ +G R Q
Sbjct: 354 AFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQ 413
Query: 325 FASLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCAL 384
+S+V A V+LL+++ + F+ L +VLA +I+ ++ L + +LP LWR D +
Sbjct: 414 LSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALV 473
Query: 385 WMMTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIIT 444
W T ++ + + + GL+ V+ + R+ R + LL +I +T Y ++ ++
Sbjct: 474 WAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVP 533
Query: 445 IPGVKIFQCCSSITFVN 461
PGV++F+ + + N
Sbjct: 534 EPGVRVFRFGGPLYYAN 550
Score = 65.5 bits (158), Expect = 2e-10
Identities = 40/164 (24%), Positives = 77/164 (46%), Gaps = 22/164 (13%)
Query: 62 CRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLI 121
C CS + + P W+ YR +++L GD+++G+ +G++ VPQ + SLLA +
Sbjct: 39 CSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAG--L 96
Query: 122 PPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK--------------VSPF 167
P+ Y +F +++IY + G+ +S+G F L+ ++ V+ + P
Sbjct: 97 QPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPG 156
Query: 168 NNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQII 211
N + GS + Y ++ V T +TG+ Q++
Sbjct: 157 ANSSTLNGSAAMLDCGRDCY------AIRVATALTLMTGLYQVL 194
Score = 46.6 bits (109), Expect = 1e-04
Identities = 36/114 (31%), Positives = 58/114 (50%), Gaps = 9/114 (7%)
Query: 588 SSPGLPDVAESQGRRSLIPYSD-ASLLPSV---HTIILDFSMVHYVDSRGLVVLRQICNA 643
S G+ + +QG L P S A+L+P+ HT+++D + + ++D+ G+ L+ +
Sbjct: 578 SETGVGEGGPAQGE-DLGPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRD 636
Query: 644 FQNANILILIAGCHSSIVRAFERNDFFDAGITKT----QLFLSVHDAVLFALSR 693
+ I +L+A C + R F G T QLFLSVHDAV A +R
Sbjct: 637 YGALGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARAR 690
>gi|45827802 prestin isoform c [Homo sapiens]
Length = 516
Score = 136 bits (342), Expect = 1e-31
Identities = 64/187 (34%), Positives = 114/187 (60%)
Query: 230 LIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLGKKIASLHNYSVNSNQDLI 289
++ +P L P PD SL + + A ++++V + I + K +A+ H Y V+ NQ+LI
Sbjct: 317 VVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLANKHGYQVDGNQELI 376
Query: 290 AIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGAGVMLLLMVKMGHFFYTLP 349
A+GLCN + S F++ + +++R+++Q+ +GG+ Q A + + ++LL+++ G F +LP
Sbjct: 377 ALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMILLVILATGFLFESLP 436
Query: 350 NAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSSSIFLGLDIGLIISVVSAF 409
AVL+ I++ N+ S+LP WR + + +W+ TF SS+FLGLD GLI +V+ A
Sbjct: 437 QAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFLGLDYGLITAVIIAL 496
Query: 410 FITTVRS 416
R+
Sbjct: 497 LTVIYRT 503
Score = 72.4 bits (176), Expect = 2e-12
Identities = 45/147 (30%), Positives = 79/147 (53%), Gaps = 9/147 (6%)
Query: 64 CSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPP 123
C+ + + P +W+ Y+ K+++LGDL++GIS G++Q+PQGL ++LA +PP
Sbjct: 52 CTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLA--AVPP 109
Query: 124 LNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSF-VKNEF 182
+ Y++F ++Y G+ +SIG F ++S L+I + V + ++ G N
Sbjct: 110 IFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIGGVAVRLVPDDIVIPGGVNATNGT 168
Query: 183 SAPSYLMGYNKSLSVVATTTFLTGIIQ 209
A L + V + T L+GIIQ
Sbjct: 169 EARDAL-----RVKVAMSVTLLSGIIQ 190
>gi|16306483 solute carrier family 26, member 7 isoform a [Homo
sapiens]
Length = 656
Score = 100 bits (250), Expect = 4e-21
Identities = 67/255 (26%), Positives = 115/255 (45%), Gaps = 2/255 (0%)
Query: 207 IIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFL 266
++ II + +M ++ IP P P ++L +I +AF ++LV
Sbjct: 263 LVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVA 322
Query: 267 LIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFA 326
+ L + A YS++ NQ+ +A GL N+VSSFF A+ RT +G + Q A
Sbjct: 323 SLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVA 382
Query: 327 SLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWM 386
L+ +L+++ +G Y LP VLA II+ + L +L W D+ D +W+
Sbjct: 383 CLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWV 442
Query: 387 MTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIP 446
T+ +I ++GL+ VV I R RA + + + + + T+
Sbjct: 443 STYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEF--KVKTEMDSETLQ 500
Query: 447 GVKIFQCCSSITFVN 461
VKI + + F+N
Sbjct: 501 QVKIISINNPLVFLN 515
Score = 63.5 bits (153), Expect = 8e-10
Identities = 41/138 (29%), Positives = 70/138 (50%), Gaps = 5/138 (3%)
Query: 78 PFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIY 137
P L+W Y LK+ LL D ++GI + + QV QGL ++L+ + P+ Y + ++IY
Sbjct: 33 PILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSS--VHPVFGLYGSLFPAIIY 90
Query: 138 VIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSV 197
IFG H ++ G+F L S + N ++ N Q + + + M + + V
Sbjct: 91 AIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEM---QRIHV 147
Query: 198 VATTTFLTGIIQIIGFTV 215
A +FL G+IQ+ F +
Sbjct: 148 AAAVSFLGGVIQVAMFVL 165
>gi|20336282 solute carrier family 26, member 7 isoform b [Homo
sapiens]
Length = 663
Score = 100 bits (250), Expect = 4e-21
Identities = 67/255 (26%), Positives = 115/255 (45%), Gaps = 2/255 (0%)
Query: 207 IIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFL 266
++ II + +M ++ IP P P ++L +I +AF ++LV
Sbjct: 263 LVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVA 322
Query: 267 LIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFA 326
+ L + A YS++ NQ+ +A GL N+VSSFF A+ RT +G + Q A
Sbjct: 323 SLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVA 382
Query: 327 SLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWM 386
L+ +L+++ +G Y LP VLA II+ + L +L W D+ D +W+
Sbjct: 383 CLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWV 442
Query: 387 MTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIP 446
T+ +I ++GL+ VV I R RA + + + + + T+
Sbjct: 443 STYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEF--KVKTEMDSETLQ 500
Query: 447 GVKIFQCCSSITFVN 461
VKI + + F+N
Sbjct: 501 QVKIISINNPLVFLN 515
Score = 63.5 bits (153), Expect = 8e-10
Identities = 41/138 (29%), Positives = 70/138 (50%), Gaps = 5/138 (3%)
Query: 78 PFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIY 137
P L+W Y LK+ LL D ++GI + + QV QGL ++L+ + P+ Y + ++IY
Sbjct: 33 PILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSS--VHPVFGLYGSLFPAIIY 90
Query: 138 VIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSV 197
IFG H ++ G+F L S + N ++ N Q + + + M + + V
Sbjct: 91 AIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEM---QRIHV 147
Query: 198 VATTTFLTGIIQIIGFTV 215
A +FL G+IQ+ F +
Sbjct: 148 AAAVSFLGGVIQVAMFVL 165
>gi|65506789 solute carrier family 26, member 10 [Homo sapiens]
Length = 563
Score = 91.3 bits (225), Expect = 4e-18
Identities = 52/178 (29%), Positives = 96/178 (53%)
Query: 207 IIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFL 266
++ ++ +V+ S+ T ++ ++P F P+ P+ + LP+I+ + ++LVS +
Sbjct: 234 VVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQPLLPNLAELPRILADSLPIALVSFAV 293
Query: 267 LIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFA 326
L A ++Y+++SNQ+ +A G N++SS F + +A T + +GG+ Q A
Sbjct: 294 SASLASIHADKYSYTIDSNQEFLAHGASNLISSLFSCFPNSATLATTNLLVDAGGKTQLA 353
Query: 327 SLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCAL 384
L V+L +++ +G FFY LP AVLA I +S++ + LP LW + D L
Sbjct: 354 GLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSMRQVFCQMQELPQLWHISRVDFLL 411
Score = 47.0 bits (110), Expect = 8e-05
Identities = 30/91 (32%), Positives = 49/91 (53%), Gaps = 5/91 (5%)
Query: 616 VHTIILDFSMVHYVDSRG----LVVLRQICNAFQNANILILIAGCHSSIVRAFERNDFFD 671
V ++LDFS V + D+ G + V ++ + ++A I +L+A C++ + R D
Sbjct: 464 VRVVVLDFSGVTFADAAGAREVVQVRERLASRCRDARIRLLLAQCNALVQGTLTRVGLLD 523
Query: 672 AGITKTQLFLSVHDAVLFALSRKVIGSSELS 702
+T QLF+SV DA +AL + GSS S
Sbjct: 524 R-VTPDQLFVSVQDAAAYALGSLLRGSSTRS 553
Score = 30.0 bits (66), Expect = 9.6
Identities = 15/48 (31%), Positives = 28/48 (58%), Gaps = 2/48 (4%)
Query: 110 GLTLSLLARQLIPPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSAL 157
G+ +LLA +PP+ Y +F +IY + G+ +S G+F ++S +
Sbjct: 41 GMAFALLAS--VPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILSLM 86
>gi|45827804 prestin isoform d [Homo sapiens]
Length = 335
Score = 72.4 bits (176), Expect = 2e-12
Identities = 45/147 (30%), Positives = 79/147 (53%), Gaps = 9/147 (6%)
Query: 64 CSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPP 123
C+ + + P +W+ Y+ K+++LGDL++GIS G++Q+PQGL ++LA +PP
Sbjct: 52 CTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLA--AVPP 109
Query: 124 LNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSF-VKNEF 182
+ Y++F ++Y G+ +SIG F ++S L+I + V + ++ G N
Sbjct: 110 IFGLYSSFYPVIMYCFLGTSRHISIGPFAVIS-LMIGGVAVRLVPDDIVIPGGVNATNGT 168
Query: 183 SAPSYLMGYNKSLSVVATTTFLTGIIQ 209
A L + V + T L+GIIQ
Sbjct: 169 EARDAL-----RVKVAMSVTLLSGIIQ 190
>gi|85540447 solute carrier family 26, member 11 [Homo sapiens]
Length = 606
Score = 70.1 bits (170), Expect = 8e-12
Identities = 44/143 (30%), Positives = 76/143 (53%), Gaps = 6/143 (4%)
Query: 268 IFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFAS 327
I + K AS +NY +++NQ+L+AIGL N++ S S TG+ RT + +SG
Sbjct: 322 IAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYPVTGSFGRTAVNAQSGVCTPAGG 381
Query: 328 LVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYD----CA 383
LV ++LL + + FY +P + LA +I+ V P +T +LWR + D C
Sbjct: 382 LVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAVAPLFDT-KIFRTLWRVKRLDLLPLCV 440
Query: 384 LWMMTFSSSIFLGLDIGLIISVV 406
+++ F + G+ G ++S++
Sbjct: 441 TFLLCF-WEVQYGILAGALVSLL 462
Score = 53.1 bits (126), Expect = 1e-06
Identities = 57/206 (27%), Positives = 87/206 (42%), Gaps = 38/206 (18%)
Query: 78 PFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIY 137
P L W+ Y L+ WL D +AG+SVGL +PQ L + +A +PP Y+AF +Y
Sbjct: 35 PILAWLPSYSLQ-WLKMDFVAGLSVGLTAIPQALAYAEVAG--LPPQYGLYSAFMGCFVY 91
Query: 138 VIFGSCHQMSIGSFFLVSALLINVLKVSP-------FNNG--QLVMG----SFVKNEFSA 184
G+ +++G ++S L+ P F +G QL MG F+ + S
Sbjct: 92 FFLGTSRDVTLGPTAIMSLLVSFYTFHEPAYAVLLAFLSGCIQLAMGVLRLGFLLDFISY 151
Query: 185 PSYLMGYNKSLSVVATTTFLTGIIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTP 244
P + G+ + +V IGF I N + + IP F L V
Sbjct: 152 P-VIKGFTSAAAVT------------IGFGQIKNLLGLQN---------IPRPFFLQVYH 189
Query: 245 DFSLLPKIILQAFSLSLVSSFLLIFL 270
F + + + L LV LL+ L
Sbjct: 190 TFLRIAETRVGDAVLGLVCMLLLLVL 215
>gi|20336274 solute carrier family 26, member 1 isoform b [Homo
sapiens]
Length = 224
Score = 63.5 bits (153), Expect = 8e-10
Identities = 40/162 (24%), Positives = 75/162 (46%), Gaps = 22/162 (13%)
Query: 62 CRCSWHRFLRCMLTIFPFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLI 121
C CS + + P W+ YR +++L GD+++G+ +G++ VPQ + SLLA +
Sbjct: 39 CSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAG--L 96
Query: 122 PPLNIAYAAFCSSVIYVIFGSCHQMSIGSFFLVSALLINVLK--------------VSPF 167
P+ Y +F +++IY + G+ +S+G F L+ ++ V+ + P
Sbjct: 97 QPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPG 156
Query: 168 NNGQLVMGSFVKNEFSAPSYLMGYNKSLSVVATTTFLTGIIQ 209
N + GS + Y ++ V T +TG+ Q
Sbjct: 157 ANSSTLNGSAAMLDCGRDCY------AIRVATALTLMTGLYQ 192
>gi|4505419 nucleolar protein 3 [Homo sapiens]
Length = 208
Score = 50.8 bits (120), Expect = 5e-06
Identities = 27/67 (40%), Positives = 39/67 (58%), Gaps = 6/67 (8%)
Query: 745 IQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPE 804
+Q EE E +LE E+ +EA + + E EPE+EP+AE E + + E EP PE EP+
Sbjct: 145 VQSGTPEEPEPELEAEASKEA------EPEPEPEPELEPEAEAEPEPELEPEPDPEPEPD 198
Query: 805 MEPNPKS 811
E +S
Sbjct: 199 FEERDES 205
Score = 40.4 bits (93), Expect = 0.007
Identities = 16/39 (41%), Positives = 23/39 (58%)
Query: 782 EPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQ 820
EP+ E E + E EP+PE EPE+EP ++ P P+
Sbjct: 152 EPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPE 190
Score = 38.9 bits (89), Expect = 0.021
Identities = 18/45 (40%), Positives = 25/45 (55%)
Query: 776 ELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQ 820
E EPE+E +A E + + E EP+ E E E EP P+ P P+
Sbjct: 152 EPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEPE 196
Score = 38.1 bits (87), Expect = 0.035
Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 760 ESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPET--EPEMEPNPKSRP 813
E + G + + ELE E +AE E + + E+EP+ E EPE+EP P P
Sbjct: 140 EGSEAVQSGTPEEPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDPEP 195
Score = 31.6 bits (70), Expect = 3.3
Identities = 15/42 (35%), Positives = 19/42 (45%)
Query: 788 ETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHP 829
E + + E E E EPE EP P+ P A P+ P P
Sbjct: 152 EPEPELEAEASKEAEPEPEPEPELEPEAEAEPEPELEPEPDP 193
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 44.3 bits (103), Expect = 5e-04
Identities = 36/147 (24%), Positives = 69/147 (46%), Gaps = 50/147 (34%)
Query: 736 KNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEM 795
K++SPG E S LD+E ESE++ ++E EP+ EP A+ + ++Q ++
Sbjct: 440 KSLSPG-------KENVSALDMEKESEEKE--------EKESEPQPEPVAQPQPQSQPQL 484
Query: 796 EPQPETEPEMEPNPKSRP-----------------RAHTFPQQRYWPM------------ 826
+ Q +++P ++ P S+P + H P+++ +P+
Sbjct: 485 QLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVESVKLTEVPVEP 544
Query: 827 ---YHPSMASTQSQTQTRTWSVERRRH 850
HP ++S+T+TR+ S R R+
Sbjct: 545 VLTVHP---ESKSKTKTRSRSRGRARN 568
Score = 38.5 bits (88), Expect = 0.027
Identities = 38/133 (28%), Positives = 57/133 (42%), Gaps = 39/133 (29%)
Query: 705 ESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQE 764
E ET +RE+ +K +S+ + L +NV + Q V E + ++ SE E
Sbjct: 367 EEETEVRES----EKQQDSQPEEVMDVLEMVENVK--HVIADQEVMETNRVESVEPSENE 420
Query: 765 AGLGLDLDLDRELEPEME-----------------------PKAETETKTQTEMEPQPET 801
A +ELEPEME + E+E K + E EPQP
Sbjct: 421 AS--------KELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEKEEKESEPQP-- 470
Query: 802 EPEMEPNPKSRPR 814
EP +P P+S+P+
Sbjct: 471 EPVAQPQPQSQPQ 483
>gi|21361639 DIPB protein [Homo sapiens]
Length = 344
Score = 43.9 bits (102), Expect = 6e-04
Identities = 24/77 (31%), Positives = 41/77 (53%)
Query: 746 QQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEM 805
++ E E E + E ESE E+ + D + E+E E E +AE + + + E E + ETE E
Sbjct: 102 EEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAEEDNQEEGESEAEGETEAES 161
Query: 806 EPNPKSRPRAHTFPQQR 822
E +P+ A +++
Sbjct: 162 EFDPEIEMEAERVAKRK 178
Score = 40.8 bits (94), Expect = 0.005
Identities = 22/83 (26%), Positives = 43/83 (51%)
Query: 743 IKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETE 802
+K++Q E ESE E ESE+E+ + + + E E E + ++E +++ + E E + E E
Sbjct: 83 VKVEQEREIESEAGEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQESEAE 142
Query: 803 PEMEPNPKSRPRAHTFPQQRYWP 825
+ + +S T + + P
Sbjct: 143 EDNQEEGESEAEGETEAESEFDP 165
Score = 35.0 bits (79), Expect = 0.30
Identities = 20/62 (32%), Positives = 36/62 (58%), Gaps = 2/62 (3%)
Query: 750 EEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNP 809
E E +++ E E E EA G + + + E E E E + E E++ +++ E + ++E EME
Sbjct: 80 EAEVKVEQEREIESEA--GEESESEEESESEEESETEEESEDESDEESEEDSEEEMEDEQ 137
Query: 810 KS 811
+S
Sbjct: 138 ES 139
>gi|83977459 pleckstrin homology-like domain, family A, member 1
[Homo sapiens]
Length = 401
Score = 43.9 bits (102), Expect = 6e-04
Identities = 16/53 (30%), Positives = 33/53 (62%), Gaps = 1/53 (1%)
Query: 778 EPEMEPKAETETKTQTEMEPQPETEPEMEPNPKSRP-RAHTFPQQRYWPMYHP 829
+P+ +P+ + + + Q + +PQP+++P+ +P PK +P + H +P P HP
Sbjct: 310 QPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPHSHP 362
Score = 41.2 bits (95), Expect = 0.004
Identities = 16/57 (28%), Positives = 32/57 (56%), Gaps = 3/57 (5%)
Query: 776 ELEPEMEPKAETETKTQTEMEPQPETEP---EMEPNPKSRPRAHTFPQQRYWPMYHP 829
+L+P+ +P+ + + + Q++ +PQP+ +P ++ P P P H+ P P HP
Sbjct: 316 QLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHPHPHPHSHPHSHPHPHPHP 372
Score = 36.2 bits (82), Expect = 0.13
Identities = 14/52 (26%), Positives = 32/52 (61%), Gaps = 3/52 (5%)
Query: 781 MEPKAETETKTQTEMEPQPETEPEMEPNPKSRPRAHTFPQ---QRYWPMYHP 829
++ + ++ + Q +++PQP+ +P+ +P P+S+P+ P+ Q+ P HP
Sbjct: 303 VQQQPPSQPQPQPQLQPQPQPQPQPQPQPQSQPQPQPQPKPQPQQLHPYPHP 354
Score = 32.0 bits (71), Expect = 2.5
Identities = 14/59 (23%), Positives = 23/59 (38%), Gaps = 7/59 (11%)
Query: 778 EPEMEPKAETETKTQTEM-------EPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYHP 829
+P+ +P+ + + K Q + P P + P P+P P H P P P
Sbjct: 330 QPQSQPQPQPQPKPQPQQLHPYPHPHPHPHSHPHSHPHPHPHPHPHQIPHPHPQPHSQP 388
>gi|7706589 GNAS complex locus NESP55 [Homo sapiens]
Length = 245
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/63 (41%), Positives = 32/63 (50%), Gaps = 2/63 (3%)
Query: 751 EESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPK 810
E E DLEL + L + + D E E E E + E+ET +TE E P TEPE EP
Sbjct: 87 EHEEADLELSLPE--CLEYEEEFDYETESETESEIESETDFETEPETAPTTEPETEPEDD 144
Query: 811 SRP 813
P
Sbjct: 145 RGP 147
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/116 (26%), Positives = 51/116 (43%), Gaps = 3/116 (2%)
Query: 751 EESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPK 810
EE++L+L L E D + + E E E+E + + ET+ +T +PETEPE + P
Sbjct: 89 EEADLELSLPECLEYEEEFDYETESETESEIESETDFETEPETAPTTEPETEPEDDRGPV 148
Query: 811 SRPRAHTFPQQRYWPMYHPSMASTQSQTQTRTWSVERRRHPM--DSYSPEGNSNED 864
P+ TF Q ++ + S + S + + P + PE D
Sbjct: 149 V-PKHSTFGQSLTQRLHALKLRSPDASPSRAPPSTQEPQSPREGEELKPEDKDPRD 203
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 42.7 bits (99), Expect = 0.001
Identities = 27/72 (37%), Positives = 40/72 (55%), Gaps = 1/72 (1%)
Query: 735 QKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTE 794
+K SP I+ ++ E+E E + ELE EQE + + DRE + E E + E E + Q E
Sbjct: 496 EKQPSPEEIR-EREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQRE 554
Query: 795 MEPQPETEPEME 806
ME + + E E E
Sbjct: 555 MEKERKQEKEKE 566
Score = 35.4 bits (80), Expect = 0.23
Identities = 20/61 (32%), Positives = 32/61 (52%)
Query: 746 QQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEM 805
+Q E+E E D E + E+E L + + RE+E E + + E E + Q E E + + E
Sbjct: 524 EQEREKEREKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQ 583
Query: 806 E 806
E
Sbjct: 584 E 584
Score = 35.4 bits (80), Expect = 0.23
Identities = 20/57 (35%), Positives = 30/57 (52%)
Query: 750 EEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEME 806
E + E + ELE EQE ++ + +E E E+E + E E + Q E + E E E E
Sbjct: 536 ERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKE 592
Score = 34.3 bits (77), Expect = 0.51
Identities = 22/70 (31%), Positives = 36/70 (51%), Gaps = 2/70 (2%)
Query: 741 GFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPE 800
G ++ Q EE E + E E E+E L+ + ++E E E E E + + + E+E + E
Sbjct: 493 GILEKQPSPEEIREREREKEREREK--ELEKEQEQEREKEREKDRERQQEKEKELEKEQE 550
Query: 801 TEPEMEPNPK 810
+ EME K
Sbjct: 551 KQREMEKERK 560
Score = 31.6 bits (70), Expect = 3.3
Identities = 17/62 (27%), Positives = 35/62 (56%), Gaps = 1/62 (1%)
Query: 746 QQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEM 805
++ +E+E E E+E E++ +L+ +E E E++ E E + + E E + + E ++
Sbjct: 542 EKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKE-REKLEEKI 600
Query: 806 EP 807
EP
Sbjct: 601 EP 602
Score = 31.6 bits (70), Expect = 3.3
Identities = 28/144 (19%), Positives = 50/144 (34%), Gaps = 11/144 (7%)
Query: 700 ELSIDESETVIRETYSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLEL 759
E +++ + E + N + S K P F + E+ +
Sbjct: 586 ECELEKEREKLEEKIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVH 645
Query: 760 ESEQEAGL--------GLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPNPKS 811
E+E E+G G + L P + + E + Q + + Q P+ P S
Sbjct: 646 ETEPESGSQPRPAVLSGYFKQFQKSLPPRFQRQQEQMKQQQWQQQQQQGVLPQTVP---S 702
Query: 812 RPRAHTFPQQRYWPMYHPSMASTQ 835
+P + T P + P+Y P Q
Sbjct: 703 QPSSSTVPPPPHRPLYQPMQPHPQ 726
Score = 30.0 bits (66), Expect = 9.6
Identities = 17/66 (25%), Positives = 35/66 (53%), Gaps = 2/66 (3%)
Query: 744 KIQQPVEEESELDLELESEQEAGLGLDLDLDRELE--PEMEPKAETETKTQTEMEPQPET 801
++++ E++ E++ E + E+E L + ++EL+ E E + E E + + E
Sbjct: 544 ELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPR 603
Query: 802 EPEMEP 807
EP +EP
Sbjct: 604 EPNLEP 609
Score = 30.0 bits (66), Expect = 9.6
Identities = 17/59 (28%), Positives = 29/59 (49%)
Query: 750 EEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQTEMEPQPETEPEMEPN 808
E+E + ++E E +QE L+ ++E E + + E E + + E E E EPN
Sbjct: 548 EQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPN 606
Score = 30.0 bits (66), Expect = 9.6
Identities = 35/156 (22%), Positives = 62/156 (39%), Gaps = 34/156 (21%)
Query: 744 KIQQPVEEESELDLELESEQEAGL--------GLDLDLDRE--------LEPEMEP---K 784
++++ ++E E +LE + E+E L +L+ +RE EP +EP K
Sbjct: 554 EMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEK 613
Query: 785 AETETKTQTEMEP----------QPETEP---EMEPNPKSRPRAHTFPQ--QRYWPMYHP 829
E+E E EP + E P E EP S+PR +++ P
Sbjct: 614 QESENSCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPAVLSGYFKQFQKSLPP 673
Query: 830 SMASTQSQTQTRTWSVERRRHPMDSYSPEGNSNEDV 865
Q Q + + W ++++ + P S+ V
Sbjct: 674 RFQRQQEQMKQQQWQQQQQQGVLPQTVPSQPSSSTV 709
>gi|196115158 CDKN1A interacting zinc finger protein 1 isoform 4
[Homo sapiens]
Length = 818
Score = 42.0 bits (97), Expect = 0.002
Identities = 21/72 (29%), Positives = 39/72 (54%), Gaps = 5/72 (6%)
Query: 774 DRELEPEMEPKAETETKTQ----TEMEPQPETEPEMEPNPKSRPRAHTFPQQRYWPMYH- 828
D +++P+++ +A+T+T + + + QP+ + E EP + +P+ HT Q P H
Sbjct: 310 DTQVQPKLQKQAQTQTSPEHLVLQQKQVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHP 369
Query: 829 PSMASTQSQTQT 840
P+ S Q QT
Sbjct: 370 PAQVSVQPPEQT 381
Score = 32.3 bits (72), Expect = 1.9
Identities = 14/50 (28%), Positives = 28/50 (56%), Gaps = 2/50 (4%)
Query: 773 LDRELEPEMEPKAETETKTQTEMEPQ--PETEPEMEPNPKSRPRAHTFPQ 820
L +E EP+ + + + T+ Q ++PQ P + ++P ++ + HT PQ
Sbjct: 341 LQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQ 390
Score = 32.0 bits (71), Expect = 2.5
Identities = 44/172 (25%), Positives = 69/172 (40%), Gaps = 40/172 (23%)
Query: 714 YSETDKNDNSRYKMSSSFLGSQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDL 773
++ + +N + + SSS ++K+ S + PVE++S D SE+ A +D
Sbjct: 150 FNLSGRNPQKQARTSSSTTPNRKDSSSQTM----PVEDKS--DPPEGSEEAAEPRMDTPE 203
Query: 774 DRELEP--------------EMEP--KAETETKTQTEMEPQPETEPEMEPNPKSRPRAH- 816
D++L P E EP +E K E E EP + K++P+A
Sbjct: 204 DQDLPPCPEDIAKEKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARM 263
Query: 817 TFPQQ-----------------RYWPMYHPSMASTQSQTQTRTWSVERRRHP 851
T P+Q R+ P A QSQTQ R S + + P
Sbjct: 264 TVPKQTQTPDLLPEALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQP 315
Score = 30.8 bits (68), Expect = 5.7
Identities = 15/72 (20%), Positives = 34/72 (47%), Gaps = 1/72 (1%)
Query: 734 SQKNVSPGFIKIQQPVEEESELDLELESEQEAGLGLDLDLDRELEPEMEPKAETETKTQT 793
+Q SP + +QQ + + +L E E +++ + ++P+ P A+ +
Sbjct: 321 AQTQTSPEHLVLQQK-QVQPQLQQEAEPQKQVQPQVHTQAQPSVQPQEHPPAQVSVQPPE 379
Query: 794 EMEPQPETEPEM 805
+ QP T+P++
Sbjct: 380 QTHEQPHTQPQV 391
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,469,557
Number of Sequences: 37866
Number of extensions: 1349040
Number of successful extensions: 7578
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 83
Number of HSP's successfully gapped in prelim test: 118
Number of HSP's that attempted gapping in prelim test: 6349
Number of HSP's gapped (non-prelim): 839
length of query: 865
length of database: 18,247,518
effective HSP length: 111
effective length of query: 754
effective length of database: 14,044,392
effective search space: 10589471568
effective search space used: 10589471568
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.