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Search of human proteins with 20336282
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336282 solute carrier family 26, member 7 isoform b [Homo
sapiens]
(663 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336282 solute carrier family 26, member 7 isoform b [Homo s... 1314 0.0
gi|16306483 solute carrier family 26, member 7 isoform a [Homo s... 1279 0.0
gi|100913030 solute carrier family 26 member 2 [Homo sapiens] 340 2e-93
gi|4557535 solute carrier family 26, member 3 [Homo sapiens] 326 4e-89
gi|4505697 pendrin [Homo sapiens] 323 3e-88
gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo s... 311 2e-84
gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo s... 307 2e-83
gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo s... 307 2e-83
gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo s... 307 2e-83
gi|45827800 prestin isoform b [Homo sapiens] 300 2e-81
gi|39752683 prestin isoform a [Homo sapiens] 300 2e-81
gi|65506789 solute carrier family 26, member 10 [Homo sapiens] 297 2e-80
gi|45827802 prestin isoform c [Homo sapiens] 293 3e-79
gi|16418413 solute carrier family 26, member 9 isoform a [Homo s... 278 9e-75
gi|217272867 solute carrier family 26, member 9 isoform b [Homo ... 278 9e-75
gi|47131207 solute carrier family 26, member 1 isoform a [Homo s... 262 7e-70
gi|20336272 solute carrier family 26, member 1 isoform a [Homo s... 262 7e-70
gi|16418457 solute carrier family 26, member 8 isoform a [Homo s... 195 1e-49
gi|45827804 prestin isoform d [Homo sapiens] 177 4e-44
gi|85540447 solute carrier family 26, member 11 [Homo sapiens] 156 7e-38
gi|217272870 solute carrier family 26, member 9 isoform c [Homo ... 112 8e-25
gi|20336285 solute carrier family 26, member 8 isoform b [Homo s... 100 3e-21
gi|20336274 solute carrier family 26, member 1 isoform b [Homo s... 67 4e-11
gi|24430139 RNA polymerase II associated protein 1 [Homo sapiens] 31 3.2
gi|188497758 ubiquitin associated protein 2-like isoform a [Homo... 31 3.2
gi|188497756 ubiquitin associated protein 2-like isoform b [Homo... 31 3.2
gi|27735000 Na+/K+ transporting ATPase interacting 3 [Homo sapiens] 31 4.2
gi|71725371 solute carrier family 10 (sodium/bile acid cotranspo... 30 7.1
gi|237512982 voltage-gated sodium channel type V alpha isoform f... 30 9.3
gi|37622907 voltage-gated sodium channel type V alpha isoform a ... 30 9.3
>gi|20336282 solute carrier family 26, member 7 isoform b [Homo
sapiens]
Length = 663
Score = 1314 bits (3401), Expect = 0.0
Identities = 663/663 (100%), Positives = 663/663 (100%)
Query: 1 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ 60
MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
Sbjct: 1 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ 60
Query: 61 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP 120
QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
Sbjct: 61 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP 120
Query: 121 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS 180
QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
Sbjct: 121 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS 180
Query: 181 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV 240
AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
Sbjct: 181 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV 240
Query: 241 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP 300
LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
Sbjct: 241 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP 300
Query: 301 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI 360
PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
Sbjct: 301 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI 360
Query: 361 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM 420
PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
Sbjct: 361 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM 420
Query: 421 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI 480
LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
Sbjct: 421 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI 480
Query: 481 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI 540
KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
Sbjct: 481 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI 540
Query: 541 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR 600
SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
Sbjct: 541 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR 600
Query: 601 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKASYKLLFDNLDLPTM 660
SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKASYKLLFDNLDLPTM
Sbjct: 601 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKASYKLLFDNLDLPTM 660
Query: 661 PPL 663
PPL
Sbjct: 661 PPL 663
>gi|16306483 solute carrier family 26, member 7 isoform a [Homo
sapiens]
Length = 656
Score = 1279 bits (3309), Expect = 0.0
Identities = 647/650 (99%), Positives = 647/650 (99%)
Query: 1 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ 60
MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
Sbjct: 1 MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ 60
Query: 61 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP 120
QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
Sbjct: 61 QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP 120
Query: 121 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS 180
QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
Sbjct: 121 QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS 180
Query: 181 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV 240
AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
Sbjct: 181 AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV 240
Query: 241 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP 300
LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
Sbjct: 241 LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP 300
Query: 301 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI 360
PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
Sbjct: 301 PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI 360
Query: 361 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM 420
PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
Sbjct: 361 PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM 420
Query: 421 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI 480
LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
Sbjct: 421 LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI 480
Query: 481 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI 540
KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
Sbjct: 481 KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI 540
Query: 541 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR 600
SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
Sbjct: 541 SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR 600
Query: 601 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKASYKL 650
SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNK KL
Sbjct: 601 SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKL 650
>gi|100913030 solute carrier family 26 member 2 [Homo sapiens]
Length = 739
Score = 340 bits (872), Expect = 2e-93
Identities = 204/639 (31%), Positives = 340/639 (53%), Gaps = 31/639 (4%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LP+L W P Y+LK+N+L D +SG+++ + V Q +A+++L+ PV+GLY S F +IIY
Sbjct: 93 LPVLQWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPVYGLYTSFFASIIYF 152
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVPQ-------NMQNLTTQSNTSVL------GLS 138
+ G H++ G F + L+ V+R + + + +L SN S L +
Sbjct: 153 LLGTSRHISVGIFGVLCLMIGETVDRELQKAGYDNAHSAPSLGMVSNGSTLLNHTSDRIC 212
Query: 139 DFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYL 198
D I V + V+F+ GV QVAM Q+G + +++ ++S TGA+ ++TSQ KYL
Sbjct: 213 DKSCYAIMVGSTVTFIAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYL 272
Query: 199 LGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVV 258
LG+ +P +G + +VF NI L L+ SLL ++VL+ KELNE FK K+K
Sbjct: 273 LGLNLPRTNGVGSLITTWIHVFRNIHKTNLCDLITSLLCLLVLLPTKELNEHFKSKLKAP 332
Query: 259 LPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALV 318
+P++LV+++AA+ A + + Y + GHIP G P+ P N++ +V +A ++++
Sbjct: 333 IPIELVVVVAATLASHFGKLHENYNSSIAGHIPTGFMPPKVPEWNLIPSVAVDAIAISII 392
Query: 319 GYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAK 378
G+ +++L++ AKK Y++ NQE A G NI+ SFF C ++AA+ +T STG
Sbjct: 393 GFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCFTTSAALAKTLVKESTGCH 452
Query: 379 TQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDW 438
TQ++ +++ + +L+V+ I PL Y L VL I +V L+G L +FRDL K W++ ++D
Sbjct: 453 TQLSGVVTALVLLLVLLVIAPLFYSLQKSVLGVITIVNLRGALRKFRDLPKMWSISRMDT 512
Query: 439 GIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRF--PRAMTVSIKNMKEMEFKVKTEMDS 496
IW T + + + +GLL GV +I VI R P++ + + E+ V +
Sbjct: 513 VIWFVTMLSSALLSTEIGLLVGVCFSIFCVILRTQKPKSSLLGLVEESEVFESVSAYKNL 572
Query: 497 ETLQQVKIISINNPLVFLNAKKF----YTDLMNMIQKENACNQPLDDISKCEQNTLLNSL 552
+ +KI PL ++N + F Y +N I + A + K + TL
Sbjct: 573 QIKPGIKIFRFVAPLYYINKECFKSALYKQTVNPILIKVAWKKAAKRKIKEKVVTL---- 628
Query: 553 SNGNCNEEASQSC---PNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHC 609
G +E S P E +++DCS F D +G+ L EV D + + VLLA C
Sbjct: 629 --GGIQDEMSVQLSHDPLELHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAIGIQVLLAQC 686
Query: 610 TASLIKAMT--YYGNLDSEKPIFFESVSA-AISHIHSNK 645
++ ++T Y + E +F+ A A + + N+
Sbjct: 687 NPTVRDSLTNGEYCKKEEENLLFYSVYEAMAFAEVSKNQ 725
>gi|4557535 solute carrier family 26, member 3 [Homo sapiens]
Length = 764
Score = 326 bits (836), Expect = 4e-89
Identities = 213/666 (31%), Positives = 335/666 (50%), Gaps = 53/666 (7%)
Query: 33 PILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAI 92
PI W P Y LKE LL D VSGI + V QGLAFA+L + PV+GLY S FPAIIY
Sbjct: 59 PIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLF 118
Query: 93 FGMGHHVATGTFALTSLIS----ANAVERIVP-QNMQNLTTQSNTSVLGLSDFEMQRIHV 147
FG H++ G F + S++ + AV + VP +N L +N++ L D E R+
Sbjct: 119 FGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAA 178
Query: 148 AAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYIS 207
AA+V+ L G+IQ+A +L++G ++E +IS TT AA HV+ SQ+K++ + +P +
Sbjct: 179 AASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHT 238
Query: 208 GPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLII 267
P+ F + VF I+ + L+ +L+ ++V+ +VKE+N++FK K+ V +P++ ++ +
Sbjct: 239 DPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTV 298
Query: 268 AASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALA 327
A+ Y + +N + + VVG + G P P + + + FG+A+V + + ++A
Sbjct: 299 IAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVA 358
Query: 328 QGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISC 387
+ K+ Y +D NQE +A GL NIV F + A+ R+A STG KTQ+A LI
Sbjct: 359 SVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGA 418
Query: 388 IFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVF 447
I VLIV+ AIG LL L VLA++ + LKGML+QF ++ + W DK D IW+ T++F
Sbjct: 419 IIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIF 478
Query: 448 TICFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKII 505
TI +GL V + ++ R FP+ T++ + K D + VKI
Sbjct: 479 TIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIF 538
Query: 506 SINNPLVFLNAKKFYTDL--------MNMIQKENACNQPLDDISK------------CEQ 545
+P+ F N F L + +++K N + + + K C
Sbjct: 539 RCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTV 598
Query: 546 NTLLNS---LSNG------------------NCNEEASQSCPNEKC---YLILDCSGFTF 581
+T+ +S L N + N++ + K LILD S +F
Sbjct: 599 DTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSF 658
Query: 582 FDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDSE--KPIFFESVSAAIS 639
D S V L + + VDV + I+ + Y D E IFF ++ A+
Sbjct: 659 LDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVL 718
Query: 640 HIHSNK 645
HI K
Sbjct: 719 HILMKK 724
>gi|4505697 pendrin [Homo sapiens]
Length = 780
Score = 323 bits (828), Expect = 3e-88
Identities = 206/667 (30%), Positives = 339/667 (50%), Gaps = 51/667 (7%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
+PIL+W P Y +KE LL D +SG+ + QG+A+A+L++V +GLY + FP + Y
Sbjct: 69 VPILEWLPKYRVKEWLLSDVISGVSTGLVATLQGMAYALLAAVPVGYGLYSAFFPILTYF 128
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQS----NTSVLGLSDFEMQRIHV 147
IFG H++ G F + SL+ + V + P +++ + NT+++ + + R+ +
Sbjct: 129 IFGTSRHISVGPFPVVSLMVGSVVLSMAPDEHFLVSSSNGTVLNTTMIDTAARDTARVLI 188
Query: 148 AAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYIS 207
A+A++ L G+IQ+ LQ+G + +P++ TT AA V+ SQ+K +L + +
Sbjct: 189 ASALTLLVGIIQLIFGGLQIGFIVRYLADPLVGGFTTAAAFQVLVSQLKIVLNVSTKNYN 248
Query: 208 GPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLII 267
G L Y +F+NI L LL+IVV + VKELN++F+ KI V +P+++++ I
Sbjct: 249 GVLSIIYTLVEIFQNIGDTNLADFTAGLLTIVVCMAVKELNDRFRHKIPVPIPIEVIVTI 308
Query: 268 AASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALA 327
A+ Y N+E Y +V IP+G P PP+++ S ++ +F +A+V Y ++++
Sbjct: 309 IATAISYGANLEKNYNAGIVKSIPRGFLPPELPPVSLFSEMLAASFSIAVVAYAIAVSVG 368
Query: 328 QGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISC 387
+ A K+ Y+ID NQEF+A G+SNI S FF C + A+ RTA STG KTQVA +IS
Sbjct: 369 KVYATKYDYTIDGNQEFIAFGISNIFSGFFSCFVATTALSRTAVQESTGGKTQVAGIISA 428
Query: 388 IFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVF 447
V+I I A+G LL L VLA++++ LKGM +Q D+ + W +KID IWV T +
Sbjct: 429 AIVMIAILALGKLLEPLQKSVLAAVVIANLKGMFMQLCDIPRLWRQNKIDAVIWVFTCIV 488
Query: 448 TICFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKII 505
+I ++GLL G++ + V+ R FP + ++ K + E Q VKI+
Sbjct: 489 SIILGLDLGLLAGLIFGLLTVVLRVQFPSWNGLGSIPSTDIYKSTKNYKNIEEPQGVKIL 548
Query: 506 SINNPLVFLNAKKF-----YTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEE 560
++P+ + N F T + I+ N + L I K ++ L + NG ++
Sbjct: 549 RFSSPIFYGNVDGFKKCIKSTVGFDAIRVYNKRLKALRKIQKLIKSGQLRATKNGIISDA 608
Query: 561 ASQSC---PNEKC-----------------------------------YLILDCSGFTFF 582
S + P+E L+LDC +F
Sbjct: 609 VSTNNAFEPDEDIEDLEELDIPTKEIEIQVDWNSELPVKVNVPKVPIHSLVLDCGAISFL 668
Query: 583 DYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDS--EKPIFFESVSAAISH 640
D GV L + + + V+V A +I+ + G D K FF +V AI +
Sbjct: 669 DVVGVRSLRVIVKEFQRIDVNVYFASLQDYVIEKLEQCGFFDDNIRKDTFFLTVHDAILY 728
Query: 641 IHSNKAS 647
+ + S
Sbjct: 729 LQNQVKS 735
>gi|94721257 solute carrier family 26, member 6 isoform 3 [Homo
sapiens]
Length = 740
Score = 311 bits (796), Expect = 2e-84
Identities = 191/659 (28%), Positives = 344/659 (52%), Gaps = 59/659 (8%)
Query: 30 RRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAII 89
+ LP+L W P Y +++ LL D +SG+ +A+ Q+ QGLA+A+L+ + PVFGLY S +P I
Sbjct: 73 QHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFI 132
Query: 90 YAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAA 149
Y +FG H++ GTFA+ S++ + E + PQ + N S++ + + R+ VA+
Sbjct: 133 YFLFGTSRHISVGTFAVMSVMVGSVTESLAPQAL-------NDSMINETARDAARVQVAS 185
Query: 150 AVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGP 209
+S L G+ QV + ++ G ++EP++ TT AA V SQ+KY+ G+ + SGP
Sbjct: 186 TLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGP 245
Query: 210 LGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAA 269
L Y V + ++ ++ + ++ VVLV+VK LN++ ++++ + +P +L+ +I A
Sbjct: 246 LSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGA 305
Query: 270 SFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQG 329
+ Y +++ + ++VVG+IP G+ P AP + S ++ AF +A+VG+ +++L +
Sbjct: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
Query: 330 SAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIF 389
A + Y +D NQE +A GLSN++ F C P + +M R+ STG +QVA IS +F
Sbjct: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
Query: 390 VLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTI 449
+L++I +G L + LP VLA+II+V LKGML Q D++ W ++ D IW+ T+ TI
Sbjct: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
Query: 450 CFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISI 507
++GL+ V+ ++ +V+ R P + ++ V +++ ++ VK+
Sbjct: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
Query: 508 NNPLVFLNAKKFYTDL---------------------------MNMIQKENACNQ---PL 537
+ + F NA +FY+D + +QKE + PL
Sbjct: 546 SATVYFANA-EFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAGPL 604
Query: 538 DDISKC---EQNTLLNSLSNGNCNEEASQSCPNEKCY------------LILDCSGFTFF 582
+S C +Q + + + + N + P+ LILD +F
Sbjct: 605 --LSACLAPQQVSSGDKMEDATANGQEDSKAPDGSTLKALGLPQPDFHSLILDLGALSFV 662
Query: 583 DYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMT--YYGNLDSEKPIFFESVSAAIS 639
D + L ++ D + V+V +A C + ++ + ++ + K F SV A++
Sbjct: 663 DTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFFDASITKKHLFASVHDAVT 721
>gi|94721259 solute carrier family 26, member 6 isoform 4 [Homo
sapiens]
Length = 738
Score = 307 bits (787), Expect = 2e-83
Identities = 164/497 (32%), Positives = 291/497 (58%), Gaps = 10/497 (2%)
Query: 30 RRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAII 89
+ LP+L W P Y +++ LL D +SG+ +A+ Q+ QGLA+A+L+ + PVFGLY S +P I
Sbjct: 52 QHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFI 111
Query: 90 YAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAA 149
Y +FG H++ GTFA+ S++ + E + PQ + N S++ + + R+ VA+
Sbjct: 112 YFLFGTSRHISVGTFAVMSVMVGSVTESLAPQAL-------NDSMINETARDAARVQVAS 164
Query: 150 AVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGP 209
+S L G+ QV + ++ G ++EP++ TT AA V SQ+KY+ G+ + SGP
Sbjct: 165 TLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGP 224
Query: 210 LGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAA 269
L Y V + ++ ++ + ++ VVLV+VK LN++ ++++ + +P +L+ +I A
Sbjct: 225 LSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGA 284
Query: 270 SFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQG 329
+ Y +++ + ++VVG+IP G+ P AP + S ++ AF +A+VG+ +++L +
Sbjct: 285 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 344
Query: 330 SAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIF 389
A + Y +D NQE +A GLSN++ F C P + +M R+ STG +QVA IS +F
Sbjct: 345 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 404
Query: 390 VLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTI 449
+L++I +G L + LP VLA+II+V LKGML Q D++ W ++ D IW+ T+ TI
Sbjct: 405 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 464
Query: 450 CFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISI 507
++GL+ V+ ++ +V+ R P + ++ V +++ ++ VK+
Sbjct: 465 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 524
Query: 508 NNPLVFLNAKKFYTDLM 524
+ + F NA +FY+D +
Sbjct: 525 SATVYFANA-EFYSDAL 540
>gi|94721255 solute carrier family 26, member 6 isoform 2 [Homo
sapiens]
Length = 758
Score = 307 bits (787), Expect = 2e-83
Identities = 164/497 (32%), Positives = 291/497 (58%), Gaps = 10/497 (2%)
Query: 30 RRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAII 89
+ LP+L W P Y +++ LL D +SG+ +A+ Q+ QGLA+A+L+ + PVFGLY S +P I
Sbjct: 73 QHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFI 132
Query: 90 YAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAA 149
Y +FG H++ GTFA+ S++ + E + PQ + N S++ + + R+ VA+
Sbjct: 133 YFLFGTSRHISVGTFAVMSVMVGSVTESLAPQAL-------NDSMINETARDAARVQVAS 185
Query: 150 AVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGP 209
+S L G+ QV + ++ G ++EP++ TT AA V SQ+KY+ G+ + SGP
Sbjct: 186 TLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGP 245
Query: 210 LGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAA 269
L Y V + ++ ++ + ++ VVLV+VK LN++ ++++ + +P +L+ +I A
Sbjct: 246 LSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGA 305
Query: 270 SFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQG 329
+ Y +++ + ++VVG+IP G+ P AP + S ++ AF +A+VG+ +++L +
Sbjct: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
Query: 330 SAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIF 389
A + Y +D NQE +A GLSN++ F C P + +M R+ STG +QVA IS +F
Sbjct: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
Query: 390 VLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTI 449
+L++I +G L + LP VLA+II+V LKGML Q D++ W ++ D IW+ T+ TI
Sbjct: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
Query: 450 CFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISI 507
++GL+ V+ ++ +V+ R P + ++ V +++ ++ VK+
Sbjct: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
Query: 508 NNPLVFLNAKKFYTDLM 524
+ + F NA +FY+D +
Sbjct: 546 SATVYFANA-EFYSDAL 561
>gi|94721253 solute carrier family 26, member 6 isoform 1 [Homo
sapiens]
Length = 759
Score = 307 bits (787), Expect = 2e-83
Identities = 164/497 (32%), Positives = 291/497 (58%), Gaps = 10/497 (2%)
Query: 30 RRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAII 89
+ LP+L W P Y +++ LL D +SG+ +A+ Q+ QGLA+A+L+ + PVFGLY S +P I
Sbjct: 73 QHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFI 132
Query: 90 YAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAA 149
Y +FG H++ GTFA+ S++ + E + PQ + N S++ + + R+ VA+
Sbjct: 133 YFLFGTSRHISVGTFAVMSVMVGSVTESLAPQAL-------NDSMINETARDAARVQVAS 185
Query: 150 AVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGP 209
+S L G+ QV + ++ G ++EP++ TT AA V SQ+KY+ G+ + SGP
Sbjct: 186 TLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGP 245
Query: 210 LGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAA 269
L Y V + ++ ++ + ++ VVLV+VK LN++ ++++ + +P +L+ +I A
Sbjct: 246 LSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGA 305
Query: 270 SFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQG 329
+ Y +++ + ++VVG+IP G+ P AP + S ++ AF +A+VG+ +++L +
Sbjct: 306 TGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKI 365
Query: 330 SAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIF 389
A + Y +D NQE +A GLSN++ F C P + +M R+ STG +QVA IS +F
Sbjct: 366 FALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLF 425
Query: 390 VLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTI 449
+L++I +G L + LP VLA+II+V LKGML Q D++ W ++ D IW+ T+ TI
Sbjct: 426 ILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATI 485
Query: 450 CFAANVGLLFGVVCTIAIVIGR--FPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISI 507
++GL+ V+ ++ +V+ R P + ++ V +++ ++ VK+
Sbjct: 486 LLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRS 545
Query: 508 NNPLVFLNAKKFYTDLM 524
+ + F NA +FY+D +
Sbjct: 546 SATVYFANA-EFYSDAL 561
>gi|45827800 prestin isoform b [Homo sapiens]
Length = 685
Score = 300 bits (769), Expect = 2e-81
Identities = 163/487 (33%), Positives = 267/487 (54%), Gaps = 4/487 (0%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LPI W P Y KE +L D VSGI V Q+ QGLAFA+L++V P+FGLY S +P I+Y
Sbjct: 65 LPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYC 124
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAV 151
G H++ G FA+ SL+ R+VP ++ + + G + R+ VA +V
Sbjct: 125 FLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATNGTEARDALRVKVAMSV 182
Query: 152 SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLG 211
+ L G+IQ + V + G +TEP++ TT AA HV TS +KYL G+K SG
Sbjct: 183 TLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFS 242
Query: 212 FFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271
Y V +N+K++ + +L + L+ +L+ KE NE+FK K+ +P++ ++ +
Sbjct: 243 VVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTG 302
Query: 272 ACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSA 331
N++ +Y ++VVG +P G+ P P ++ V +A +A+VG+ ++++A+ A
Sbjct: 303 ISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLA 362
Query: 332 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL 391
K Y +D NQE +A GL N + S F + ++ R+ TG KTQ+A ++ + +L
Sbjct: 363 NKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMIL 422
Query: 392 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF 451
+VI A G L LP VL++I++V LKGM +QF DL +W KI+ IW++T+V ++
Sbjct: 423 LVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFL 482
Query: 452 AANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSET--LQQVKIISINN 509
+ GL+ V+ + VI R + + E + + + E + +KI IN
Sbjct: 483 GLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINA 542
Query: 510 PLVFLNA 516
P+ + N+
Sbjct: 543 PIYYANS 549
>gi|39752683 prestin isoform a [Homo sapiens]
Length = 744
Score = 300 bits (769), Expect = 2e-81
Identities = 163/487 (33%), Positives = 267/487 (54%), Gaps = 4/487 (0%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LPI W P Y KE +L D VSGI V Q+ QGLAFA+L++V P+FGLY S +P I+Y
Sbjct: 65 LPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYC 124
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAV 151
G H++ G FA+ SL+ R+VP ++ + + G + R+ VA +V
Sbjct: 125 FLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATNGTEARDALRVKVAMSV 182
Query: 152 SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLG 211
+ L G+IQ + V + G +TEP++ TT AA HV TS +KYL G+K SG
Sbjct: 183 TLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFS 242
Query: 212 FFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271
Y V +N+K++ + +L + L+ +L+ KE NE+FK K+ +P++ ++ +
Sbjct: 243 VVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTG 302
Query: 272 ACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSA 331
N++ +Y ++VVG +P G+ P P ++ V +A +A+VG+ ++++A+ A
Sbjct: 303 ISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLA 362
Query: 332 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL 391
K Y +D NQE +A GL N + S F + ++ R+ TG KTQ+A ++ + +L
Sbjct: 363 NKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMIL 422
Query: 392 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF 451
+VI A G L LP VL++I++V LKGM +QF DL +W KI+ IW++T+V ++
Sbjct: 423 LVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFL 482
Query: 452 AANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSET--LQQVKIISINN 509
+ GL+ V+ + VI R + + E + + + E + +KI IN
Sbjct: 483 GLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYEEVKEIPGIKIFQINA 542
Query: 510 PLVFLNA 516
P+ + N+
Sbjct: 543 PIYYANS 549
>gi|65506789 solute carrier family 26, member 10 [Homo sapiens]
Length = 563
Score = 297 bits (760), Expect = 2e-80
Identities = 151/374 (40%), Positives = 236/374 (63%), Gaps = 5/374 (1%)
Query: 65 GLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVPQNMQ 124
G+AFA+L+SV PVFGLY S FP +IY++ G G H++TGTFA+ SL++ +AVER+VP+ +
Sbjct: 41 GMAFALLASVPPVFGLYTSFFPVLIYSLLGTGRHLSTGTFAILSLMTGSAVERLVPEPLV 100
Query: 125 NLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTT 184
N S + + QR+ VAAAV+F G + + MFVLQLG + ++EPV+ A+T+
Sbjct: 101 G-----NLSGIEKEQLDAQRVGVAAAVAFGSGALMLGMFVLQLGVLSTFLSEPVVKALTS 155
Query: 185 GAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLV 244
GAA HV+ SQ+ LLG+ +P G F A + + L +S LS+ +LV V
Sbjct: 156 GAALHVLLSQLPSLLGLSLPRQIGCFSLFKTLASLLTALPRSSPAELTISALSLALLVPV 215
Query: 245 KELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNI 304
KELN +F+ ++ +P ++VL++ AS C+ ++++ Y +++VG +P G P P P +
Sbjct: 216 KELNVRFRDRLPTPIPGEVVLVLLASVLCFTSSVDTRYQVQIVGLLPGGFPQPLLPNLAE 275
Query: 305 LSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAA 364
L ++ ++ +ALV + S +LA A K+ Y+ID NQEFLAHG SN++SS F C P++A
Sbjct: 276 LPRILADSLPIALVSFAVSASLASIHADKYSYTIDSNQEFLAHGASNLISSLFSCFPNSA 335
Query: 365 AMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQF 424
+ T L G KTQ+A L SC VL V+ +GP Y+LP VLA I + ++ + Q
Sbjct: 336 TLATTNLLVDAGGKTQLAGLFSCTVVLSVLLWLGPFFYYLPKAVLACINISSMRQVFCQM 395
Query: 425 RDLKKYWNVDKIDW 438
++L + W++ ++D+
Sbjct: 396 QELPQLWHISRVDF 409
Score = 35.0 bits (79), Expect = 0.22
Identities = 25/74 (33%), Positives = 37/74 (50%), Gaps = 5/74 (6%)
Query: 572 LILDCSGFTFFDYSGVSMLVEVY----MDCKGRSVDVLLAHCTASLIKAMTYYGNLDSEK 627
++LD SG TF D +G +V+V C+ + +LLA C A + +T G LD
Sbjct: 467 VVLDFSGVTFADAAGAREVVQVRERLASRCRDARIRLLLAQCNALVQGTLTRVGLLDRVT 526
Query: 628 P-IFFESVSAAISH 640
P F SV A ++
Sbjct: 527 PDQLFVSVQDAAAY 540
>gi|45827802 prestin isoform c [Homo sapiens]
Length = 516
Score = 293 bits (750), Expect = 3e-79
Identities = 155/440 (35%), Positives = 249/440 (56%), Gaps = 2/440 (0%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LPI W P Y KE +L D VSGI V Q+ QGLAFA+L++V P+FGLY S +P I+Y
Sbjct: 65 LPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYC 124
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAV 151
G H++ G FA+ SL+ R+VP ++ + + G + R+ VA +V
Sbjct: 125 FLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATNGTEARDALRVKVAMSV 182
Query: 152 SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLG 211
+ L G+IQ + V + G +TEP++ TT AA HV TS +KYL G+K SG
Sbjct: 183 TLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFS 242
Query: 212 FFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271
Y V +N+K++ + +L + L+ +L+ KE NE+FK K+ +P++ ++ +
Sbjct: 243 VVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTG 302
Query: 272 ACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSA 331
N++ +Y ++VVG +P G+ P P ++ V +A +A+VG+ ++++A+ A
Sbjct: 303 ISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIAIVGFSVTISMAKTLA 362
Query: 332 KKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVL 391
K Y +D NQE +A GL N + S F + ++ R+ TG KTQ+A ++ + +L
Sbjct: 363 NKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTGGKTQLAGCLASLMIL 422
Query: 392 IVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICF 451
+VI A G L LP VL++I++V LKGM +QF DL +W KI+ IW++T+V ++
Sbjct: 423 LVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKIELTIWLTTFVSSLFL 482
Query: 452 AANVGLLFGVVCTIAIVIGR 471
+ GL+ V+ + VI R
Sbjct: 483 GLDYGLITAVIIALLTVIYR 502
>gi|16418413 solute carrier family 26, member 9 isoform a [Homo
sapiens]
Length = 791
Score = 278 bits (712), Expect = 9e-75
Identities = 153/491 (31%), Positives = 266/491 (54%), Gaps = 3/491 (0%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LP+L W P Y +K+ ++PD + G+ QV QG+AFA+L+++ V GLY S FP + Y
Sbjct: 56 LPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYF 115
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVPQN-MQNLTTQSNTSVLGLSDFEMQRIHVAAA 150
G H + GTFA+ S++ N ++ P++ Q +N S + + E +R+HV+A
Sbjct: 116 FLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSAT 175
Query: 151 VSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPL 210
++ L +IQ+ + +Q G ++E I T A ++ S +KY+ G+ +P +GP
Sbjct: 176 LACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPG 235
Query: 211 GFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAAS 270
+ + + +N+ + +L+ +L+S LVLVKELN ++ KI+ +P ++++++ A+
Sbjct: 236 SIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVAT 295
Query: 271 FACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGS 330
M Y +++VG I +G P+P +P ++ +I AF +A+V YV +LA+ +
Sbjct: 296 AISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTL 355
Query: 331 AKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFV 390
A K Y +D NQE +A G SN SFF A+ T + G K+QVA L + V
Sbjct: 356 ANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVV 415
Query: 391 LIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTIC 450
+I + +G LY LP VL ++I V LK L Q D W K+D IWV +++ +
Sbjct: 416 MITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFF 475
Query: 451 FAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKV--KTEMDSETLQQVKIISIN 508
+ G+ GV ++ +V+ + ++ + + + V KT ++ +Q +KII+
Sbjct: 476 LSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYC 535
Query: 509 NPLVFLNAKKF 519
+PL F N++ F
Sbjct: 536 SPLYFANSEIF 546
>gi|217272867 solute carrier family 26, member 9 isoform b [Homo
sapiens]
Length = 887
Score = 278 bits (712), Expect = 9e-75
Identities = 153/491 (31%), Positives = 266/491 (54%), Gaps = 3/491 (0%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LP+L W P Y +K+ ++PD + G+ QV QG+AFA+L+++ V GLY S FP + Y
Sbjct: 56 LPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYF 115
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVPQN-MQNLTTQSNTSVLGLSDFEMQRIHVAAA 150
G H + GTFA+ S++ N ++ P++ Q +N S + + E +R+HV+A
Sbjct: 116 FLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSAT 175
Query: 151 VSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPL 210
++ L +IQ+ + +Q G ++E I T A ++ S +KY+ G+ +P +GP
Sbjct: 176 LACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPG 235
Query: 211 GFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAAS 270
+ + + +N+ + +L+ +L+S LVLVKELN ++ KI+ +P ++++++ A+
Sbjct: 236 SIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVAT 295
Query: 271 FACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGS 330
M Y +++VG I +G P+P +P ++ +I AF +A+V YV +LA+ +
Sbjct: 296 AISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTL 355
Query: 331 AKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFV 390
A K Y +D NQE +A G SN SFF A+ T + G K+QVA L + V
Sbjct: 356 ANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVV 415
Query: 391 LIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTIC 450
+I + +G LY LP VL ++I V LK L Q D W K+D IWV +++ +
Sbjct: 416 MITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFF 475
Query: 451 FAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKV--KTEMDSETLQQVKIISIN 508
+ G+ GV ++ +V+ + ++ + + + V KT ++ +Q +KII+
Sbjct: 476 LSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYC 535
Query: 509 NPLVFLNAKKF 519
+PL F N++ F
Sbjct: 536 SPLYFANSEIF 546
>gi|47131207 solute carrier family 26, member 1 isoform a [Homo
sapiens]
Length = 701
Score = 262 bits (670), Expect = 7e-70
Identities = 164/597 (27%), Positives = 296/597 (49%), Gaps = 18/597 (3%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LP W Y +E L D +SG+++ + V Q +A+++L+ + P++ LY S F +IY
Sbjct: 54 LPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYF 113
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVP-----QNMQNLTTQSNTSVLGLSDFEMQ--- 143
+ G HV+ G F+L L+ V+R + + L +N+S L S +
Sbjct: 114 LMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSSTLNGSAAMLDCGR 173
Query: 144 ---RIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLG 200
I VA A++ + G+ QV M VL+LG + +++P++ GA+ ++TSQ+K+LLG
Sbjct: 174 DCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLG 233
Query: 201 MKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLP 260
+++P GP + + + ++ S + + VL+ KEL+++++ +++V LP
Sbjct: 234 VRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLP 293
Query: 261 VDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGY 320
+L++I+ A+ + + +G V G IP G P+ P ++ V +A +ALV
Sbjct: 294 TELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVALALVAA 353
Query: 321 VASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQ 380
S++LA+ A+ YS+ NQE LA G N++ +F C ++AA+ ++ +TG +TQ
Sbjct: 354 AFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQ 413
Query: 381 VACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGI 440
++ ++S VL+V+ A+ PL + L VLA +IVV L+G L + DL + W + D +
Sbjct: 414 LSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALV 473
Query: 441 WVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEF-KVKTEMDSETL 499
W T + + GLL GV+ ++ + GR R T + + + F + TE +
Sbjct: 474 WAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVP 533
Query: 500 QQ-VKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCN 558
+ V++ PL + N F L ++ + C E + G
Sbjct: 534 EPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAARRKEGGSETGVGEGGPAQGEDL 593
Query: 559 EEASQSC---PNEKCY--LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCT 610
S P + +++DC+ F D +GVS L ++ D + +LLA C+
Sbjct: 594 GPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCS 650
>gi|20336272 solute carrier family 26, member 1 isoform a [Homo
sapiens]
Length = 701
Score = 262 bits (670), Expect = 7e-70
Identities = 164/597 (27%), Positives = 296/597 (49%), Gaps = 18/597 (3%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LP W Y +E L D +SG+++ + V Q +A+++L+ + P++ LY S F +IY
Sbjct: 54 LPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYF 113
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVP-----QNMQNLTTQSNTSVLGLSDFEMQ--- 143
+ G HV+ G F+L L+ V+R + + L +N+S L S +
Sbjct: 114 LMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSSTLNGSAAMLDCGR 173
Query: 144 ---RIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLG 200
I VA A++ + G+ QV M VL+LG + +++P++ GA+ ++TSQ+K+LLG
Sbjct: 174 DCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLG 233
Query: 201 MKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLP 260
+++P GP + + + ++ S + + VL+ KEL+++++ +++V LP
Sbjct: 234 VRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLP 293
Query: 261 VDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGY 320
+L++I+ A+ + + +G V G IP G P+ P ++ V +A +ALV
Sbjct: 294 TELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVALALVAA 353
Query: 321 VASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQ 380
S++LA+ A+ YS+ NQE LA G N++ +F C ++AA+ ++ +TG +TQ
Sbjct: 354 AFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQ 413
Query: 381 VACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGI 440
++ ++S VL+V+ A+ PL + L VLA +IVV L+G L + DL + W + D +
Sbjct: 414 LSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALV 473
Query: 441 WVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEF-KVKTEMDSETL 499
W T + + GLL GV+ ++ + GR R T + + + F + TE +
Sbjct: 474 WAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVP 533
Query: 500 QQ-VKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCN 558
+ V++ PL + N F L ++ + C E + G
Sbjct: 534 EPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAARRKEGGSETGVGEGGPAQGEDL 593
Query: 559 EEASQSC---PNEKCY--LILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCT 610
S P + +++DC+ F D +GVS L ++ D + +LLA C+
Sbjct: 594 GPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCS 650
>gi|16418457 solute carrier family 26, member 8 isoform a [Homo
sapiens]
Length = 970
Score = 195 bits (495), Expect = 1e-49
Identities = 134/490 (27%), Positives = 231/490 (47%), Gaps = 8/490 (1%)
Query: 33 PILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSS--VHPVFGLYGSLFPAIIY 90
P L+W Y LK+ LL D ++GI + + QV QGL ++L+ + P+ Y + ++IY
Sbjct: 78 PFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIY 137
Query: 91 AIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEM---QRIHV 147
IFG H ++ G+F L S + N ++ N Q + + + M + + V
Sbjct: 138 VIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSV 197
Query: 148 AAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYIS 207
A +FL G+IQ+ M VL LG + E +SA A H++ SQ+ ++ G+ + + +
Sbjct: 198 VATTTFLTGIIQLIMGVLGLGFIATYLPESAMSAYLAAVALHIMLSQLTFIFGIMISFHA 257
Query: 208 GPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLII 267
GP+ FFY + ++L+ L +V L + K + F + + P++L LII
Sbjct: 258 GPISFFYDIINYCVALPKANSTSILVFLTVVVALRINKCIRISFNQ-YPIEFPMELFLII 316
Query: 268 AASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALA 327
+ +M ++ IP P P ++L +I +AF ++LV + L
Sbjct: 317 GFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFLLIFLG 376
Query: 328 QGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISC 387
+ A YS++ NQ+ +A GL N+VSSFF A+ RT +G + Q A L+
Sbjct: 377 KKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFASLVGA 436
Query: 388 IFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVF 447
+L+++ +G Y LP VLA II+ + L +L W D+ D +W+ T+
Sbjct: 437 GVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWMMTFSS 496
Query: 448 TICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEF--KVKTEMDSETLQQVKII 505
+I ++GL+ VV I R RA + + + + + T+ VKI
Sbjct: 497 SIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIPGVKIF 556
Query: 506 SINNPLVFLN 515
+ + F+N
Sbjct: 557 QCCSSITFVN 566
>gi|45827804 prestin isoform d [Homo sapiens]
Length = 335
Score = 177 bits (448), Expect = 4e-44
Identities = 94/262 (35%), Positives = 147/262 (56%), Gaps = 2/262 (0%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LPI W P Y KE +L D VSGI V Q+ QGLAFA+L++V P+FGLY S +P I+Y
Sbjct: 65 LPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAVPPIFGLYSSFYPVIMYC 124
Query: 92 IFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAV 151
G H++ G FA+ SL+ R+VP ++ + + G + R+ VA +V
Sbjct: 125 FLGTSRHISIGPFAVISLMIGGVAVRLVPDDI--VIPGGVNATNGTEARDALRVKVAMSV 182
Query: 152 SFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLG 211
+ L G+IQ + V + G +TEP++ TT AA HV TS +KYL G+K SG
Sbjct: 183 TLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLKYLFGVKTKRYSGIFS 242
Query: 212 FFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASF 271
Y V +N+K++ + +L + L+ +L+ KE NE+FK K+ +P++ ++ +
Sbjct: 243 VVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLPAPIPLEFFAVVMGTG 302
Query: 272 ACYCTNMENTYGLEVVGHIPQG 293
N++ +Y ++VVG +P G
Sbjct: 303 ISAGFNLKESYNVDVVGTLPLG 324
>gi|85540447 solute carrier family 26, member 11 [Homo sapiens]
Length = 606
Score = 156 bits (394), Expect = 7e-38
Identities = 128/477 (26%), Positives = 220/477 (46%), Gaps = 62/477 (12%)
Query: 29 RRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAI 88
+RRLPIL W P Y+L+ L D V+G+ + + + Q LA+A ++ + P +GLY +
Sbjct: 31 QRRLPILAWLPSYSLQW-LKMDFVAGLSVGLTAIPQALAYAEVAGLPPQYGLYSAFMGCF 89
Query: 89 IYAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVA 148
+Y G V G A+ SL+ +S + A
Sbjct: 90 VYFFLGTSRDVTLGPTAIMSLL--------------------------VSFYTFHEPAYA 123
Query: 149 AAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISG 208
++FL G IQ+AM VL+LG ++ PVI T+ AA + Q+K LLG++ +
Sbjct: 124 VLLAFLSGCIQLAMGVLRLGFLLDFISYPVIKGFTSAAAVTIGFGQIKNLLGLQ----NI 179
Query: 209 PLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLP---VDLVL 265
P FF + F I R+ +L L+ +++L+++K + + + P + L
Sbjct: 180 PRPFFLQVYHTFLRIAETRVGDAVLGLVCMLLLLVLKLMRDHVPPVHPEMPPGVRLSRGL 239
Query: 266 IIAASFACYCTNMENT----YGLEVVGHIP--------QGIPSPRAPPMNILSAVITEAF 313
+ AA+ A + Y EV G+ P +G+P R PP ++ +A T +F
Sbjct: 240 VWAATTARNALVVSFAALVAYSFEVTGYQPFILTGETAEGLPPVRIPPFSVTTANGTISF 299
Query: 314 G------------VALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIP 361
V L+G + S+A+A+ A + Y ID NQE LA GL+N++ S P
Sbjct: 300 TEMVQDMGAGLAVVPLMGLLESIAVAKAFASQNNYRIDANQELLAIGLTNMLGSLVSSYP 359
Query: 362 SAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGML 421
+ GRTA +G T L++ + VL+ + + L Y++P LA++I++ + L
Sbjct: 360 VTGSFGRTAVNAQSGVCTPAGGLVTGVLVLLSLDYLTSLFYYIPKSALAAVIIMAV-APL 418
Query: 422 IQFRDLKKYWNVDKIDWGIWVSTYVFTICF-AANVGLLFGVVCTIAIVIGRFPRAMT 477
+ + W V ++D + F +CF G+L G + ++ +++ R T
Sbjct: 419 FDTKIFRTLWRVKRLD--LLPLCVTFLLCFWEVQYGILAGALVSLLMLLHSAARPET 473
>gi|217272870 solute carrier family 26, member 9 isoform c [Homo
sapiens]
Length = 459
Score = 112 bits (281), Expect = 8e-25
Identities = 69/214 (32%), Positives = 111/214 (51%), Gaps = 2/214 (0%)
Query: 308 VITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMG 367
+I AF +A+V YV +LA+ + A K Y +D NQE +A G SN SFF A+
Sbjct: 1 MIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALS 60
Query: 368 RTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDL 427
T + G K+QVA L + V+I + +G LY LP VL ++I V LK L Q D
Sbjct: 61 VTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDP 120
Query: 428 KKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEME 487
W K+D IWV +++ + + G+ GV ++ +V+ + ++ + + +
Sbjct: 121 YYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTD 180
Query: 488 FKV--KTEMDSETLQQVKIISINNPLVFLNAKKF 519
V KT ++ +Q +KII+ +PL F N++ F
Sbjct: 181 IYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIF 214
>gi|20336285 solute carrier family 26, member 8 isoform b [Homo
sapiens]
Length = 865
Score = 100 bits (250), Expect = 3e-21
Identities = 67/255 (26%), Positives = 115/255 (45%), Gaps = 2/255 (0%)
Query: 263 LVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVA 322
++ II + +M ++ IP P P ++L +I +AF ++LV
Sbjct: 207 IIQIIGFTVIANKISMATETSQTLIDMIPYSFLLPVTPDFSLLPKIILQAFSLSLVSSFL 266
Query: 323 SLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVA 382
+ L + A YS++ NQ+ +A GL N+VSSFF A+ RT +G + Q A
Sbjct: 267 LIFLGKKIASLHNYSVNSNQDLIAIGLCNVVSSFFRSCVFTGAIARTIIQDKSGGRQQFA 326
Query: 383 CLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWV 442
L+ +L+++ +G Y LP VLA II+ + L +L W D+ D +W+
Sbjct: 327 SLVGAGVMLLLMVKMGHFFYTLPNAVLAGIILSNVIPYLETISNLPSLWRQDQYDCALWM 386
Query: 443 STYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEF--KVKTEMDSETLQ 500
T+ +I ++GL+ VV I R RA + + + + + T+
Sbjct: 387 MTFSSSIFLGLDIGLIISVVSAFFITTVRSHRAKILLLGQIPNTNIYRSINDYREIITIP 446
Query: 501 QVKIISINNPLVFLN 515
VKI + + F+N
Sbjct: 447 GVKIFQCCSSITFVN 461
Score = 63.5 bits (153), Expect = 6e-10
Identities = 41/138 (29%), Positives = 70/138 (50%), Gaps = 5/138 (3%)
Query: 33 PILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSS--VHPVFGLYGSLFPAIIY 90
P L+W Y LK+ LL D ++GI + + QV QGL ++L+ + P+ Y + ++IY
Sbjct: 78 PFLEWMCMYRLKDWLLGDLLAGISVGLVQVPQGLTLSLLARQLIPPLNIAYAAFCSSVIY 137
Query: 91 AIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEM---QRIHV 147
IFG H ++ G+F L S + N ++ N Q + + + M + + V
Sbjct: 138 VIFGSCHQMSIGSFFLVSALLINVLKVSPFNNGQLVMGSFVKNEFSAPSYLMGYNKSLSV 197
Query: 148 AAAVSFLGGVIQVAMFVL 165
A +FL G+IQ+ F +
Sbjct: 198 VATTTFLTGIIQIIGFTV 215
>gi|20336274 solute carrier family 26, member 1 isoform b [Homo
sapiens]
Length = 224
Score = 67.4 bits (163), Expect = 4e-11
Identities = 40/141 (28%), Positives = 70/141 (49%), Gaps = 11/141 (7%)
Query: 32 LPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYA 91
LP W Y +E L D +SG+++ + V Q +A+++L+ + P++ LY S F +IY
Sbjct: 54 LPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYF 113
Query: 92 IFGMGHHVATGTFALTSLISANAVERIV-----PQNMQNLTTQSNTSVLGLS------DF 140
+ G HV+ G F+L L+ V+R + + L +N+S L S
Sbjct: 114 LMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSSTLNGSAAMLDCGR 173
Query: 141 EMQRIHVAAAVSFLGGVIQVA 161
+ I VA A++ + G+ Q +
Sbjct: 174 DCYAIRVATALTLMTGLYQTS 194
>gi|24430139 RNA polymerase II associated protein 1 [Homo sapiens]
Length = 1393
Score = 31.2 bits (69), Expect = 3.2
Identities = 21/64 (32%), Positives = 34/64 (53%), Gaps = 5/64 (7%)
Query: 282 YGLEVVGHIPQG-IPSPRAPPMNILSAVITEA----FGVALVGYVASLALAQGSAKKFKY 336
Y L+ + H+ + + RA +++L+ VI+ A FG L G V SL L G ++
Sbjct: 390 YSLQELFHLTRSQVSQQRALALHVLAQVISRAQAGEFGDRLAGSVLSLLLDAGFLFLLRF 449
Query: 337 SIDD 340
S+DD
Sbjct: 450 SLDD 453
>gi|188497758 ubiquitin associated protein 2-like isoform a [Homo
sapiens]
Length = 1087
Score = 31.2 bits (69), Expect = 3.2
Identities = 24/89 (26%), Positives = 40/89 (44%), Gaps = 17/89 (19%)
Query: 431 WNVDKIDWGIWVSTYVFTICFAA-NVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFK 489
WN D + I+ ++ V ++ A NV + G +A+++G+ P M
Sbjct: 249 WNEDLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSTM------------- 295
Query: 490 VKTEMDSETLQQVKIISINNPLVFLNAKK 518
E DS L + S+ PLVF N+K+
Sbjct: 296 ---ENDSSNLDPSQAPSLAQPLVFSNSKQ 321
>gi|188497756 ubiquitin associated protein 2-like isoform b [Homo
sapiens]
Length = 983
Score = 31.2 bits (69), Expect = 3.2
Identities = 24/89 (26%), Positives = 40/89 (44%), Gaps = 17/89 (19%)
Query: 431 WNVDKIDWGIWVSTYVFTICFAA-NVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFK 489
WN D + I+ ++ V ++ A NV + G +A+++G+ P M
Sbjct: 249 WNEDLSETKIFTASNVSSVPLPAENVTITAGQRIDLAVLLGKTPSTM------------- 295
Query: 490 VKTEMDSETLQQVKIISINNPLVFLNAKK 518
E DS L + S+ PLVF N+K+
Sbjct: 296 ---ENDSSNLDPSQAPSLAQPLVFSNSKQ 321
>gi|27735000 Na+/K+ transporting ATPase interacting 3 [Homo sapiens]
Length = 197
Score = 30.8 bits (68), Expect = 4.2
Identities = 23/83 (27%), Positives = 41/83 (49%), Gaps = 12/83 (14%)
Query: 383 CLISCIFVLIVIYAIGPLLY------WLPMC---VLASIIVVGLKGMLIQFRDLKKYWNV 433
C + C+ L ++ A+ ++ W P+ + ++++GL G IQ+R +Y V
Sbjct: 8 CSLICLCALQLVSALERQIFDFLGFQWAPILGNFLHIIVVILGLFGT-IQYRP--RYIMV 64
Query: 434 DKIDWGIWVSTYVFTICFAANVG 456
+ +WV+ VF ICF VG
Sbjct: 65 YTVWTALWVTWNVFIICFYLEVG 87
>gi|71725371 solute carrier family 10 (sodium/bile acid
cotransporter family), member 7 isoform b [Homo sapiens]
Length = 340
Score = 30.0 bits (66), Expect = 7.1
Identities = 50/232 (21%), Positives = 89/232 (38%), Gaps = 24/232 (10%)
Query: 53 SGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISA 112
SG+ L +++T L L +F L + FPA I+ + + L L +
Sbjct: 54 SGLSLKTEELTSALVHLKLHLFIQIFTL--AFFPATIWLFLQLLSITPINEWLLKGLQTV 111
Query: 113 NAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATF 172
+ P + + T++ + E I +A SFLG VI + +L LGS++
Sbjct: 112 GCMPP--PVSSAVILTKA------VGGNEAAAIFNSAFGSFLGIVITPLLLLLFLGSSSS 163
Query: 173 VVTEPVISAMTTGAATHVVTSQV------KYLLGMKMPY--ISGPLGFFYIYAYVFENIK 224
V + S + ++ Q+ +L K P+ IS + IY +
Sbjct: 164 VPFTSIFSQLFMTVVVPLIIGQIVRRYIKDWLERKKPPFGAISSSVLLMIIYTTFCDTFS 223
Query: 225 SVRLEALLLSLLSIVVLVLVKELNEQF------KRKIKVVLPVDLVLIIAAS 270
+ ++ SL+ I+ ++ +L+ R P D V II S
Sbjct: 224 NPNIDLDKFSLVLILFIIFSIQLSFMLLTFIFSTRNNSGFTPADTVAIIFCS 275
>gi|237512982 voltage-gated sodium channel type V alpha isoform f
[Homo sapiens]
Length = 1962
Score = 29.6 bits (65), Expect = 9.3
Identities = 19/99 (19%), Positives = 42/99 (42%), Gaps = 10/99 (10%)
Query: 199 LGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVV 258
LG K P P ++F+ + + ++ L+ + ++ ++ E ++Q KI ++
Sbjct: 1447 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1506
Query: 259 LPVDLVLIIAASFAC----------YCTNMENTYGLEVV 287
++L+ + + C Y TN N + VV
Sbjct: 1507 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVV 1545
>gi|37622907 voltage-gated sodium channel type V alpha isoform a [Homo
sapiens]
Length = 2016
Score = 29.6 bits (65), Expect = 9.3
Identities = 19/99 (19%), Positives = 42/99 (42%), Gaps = 10/99 (10%)
Query: 199 LGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVV 258
LG K P P ++F+ + + ++ L+ + ++ ++ E ++Q KI ++
Sbjct: 1501 LGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINIL 1560
Query: 259 LPVDLVLIIAASFAC----------YCTNMENTYGLEVV 287
++L+ + + C Y TN N + VV
Sbjct: 1561 AKINLLFVAIFTGECIVKLAALRHYYFTNSWNIFDFVVV 1599
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.324 0.137 0.409
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,412,507
Number of Sequences: 37866
Number of extensions: 844745
Number of successful extensions: 2959
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 23
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 2879
Number of HSP's gapped (non-prelim): 58
length of query: 663
length of database: 18,247,518
effective HSP length: 109
effective length of query: 554
effective length of database: 14,120,124
effective search space: 7822548696
effective search space used: 7822548696
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.