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Search of human proteins with 20336229
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
(505 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20336229 peroxisome proliferative activated receptor gamma is... 1014 0.0
gi|116284373 peroxisome proliferative activated receptor gamma i... 959 0.0
gi|116284368 peroxisome proliferative activated receptor gamma i... 959 0.0
gi|116284370 peroxisome proliferative activated receptor gamma i... 959 0.0
gi|5453940 peroxisome proliferative activated receptor, delta is... 516 e-146
gi|50348666 peroxisome proliferative activated receptor, alpha [... 510 e-144
gi|7549811 peroxisome proliferative activated receptor, alpha [H... 510 e-144
gi|29171750 peroxisome proliferative activated receptor, delta i... 401 e-112
gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 175 8e-44
gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens] 175 8e-44
gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens] 175 8e-44
gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens] 174 1e-43
gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens] 173 3e-43
gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens] 173 3e-43
gi|194294519 nuclear receptor subfamily 1, group H, member 3 iso... 160 3e-39
gi|194294517 nuclear receptor subfamily 1, group H, member 3 iso... 160 3e-39
gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens] 155 6e-38
gi|4506755 retinoid X receptor, alpha [Homo sapiens] 150 3e-36
gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Hom... 146 4e-35
gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo... 145 6e-35
gi|14702164 nuclear receptor subfamily 1, group I, member 2 isof... 139 6e-33
gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Hom... 135 9e-32
gi|7657395 photoreceptor-specific nuclear receptor isoform b [Ho... 134 1e-31
gi|14149746 nuclear receptor subfamily 2, group F, member 2 isof... 133 4e-31
gi|224177493 nuclear receptor subfamily 1, group D, member 2 iso... 132 7e-31
gi|224177491 nuclear receptor subfamily 1, group D, member 2 iso... 132 7e-31
gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo... 131 2e-30
gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Hom... 125 7e-29
gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Hom... 125 7e-29
gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo... 124 2e-28
>gi|20336229 peroxisome proliferative activated receptor gamma
isoform 2 [Homo sapiens]
Length = 505
Score = 1014 bits (2622), Expect = 0.0
Identities = 505/505 (100%), Positives = 505/505 (100%)
Query: 1 MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF 60
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
Sbjct: 1 MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSF 60
Query: 61 DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT 120
DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
Sbjct: 61 DIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKT 120
Query: 121 QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC 180
QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
Sbjct: 121 QLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC 180
Query: 181 RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR 240
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
Sbjct: 181 RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR 240
Query: 241 ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE 300
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
Sbjct: 241 ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE 300
Query: 301 QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS 360
QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS
Sbjct: 301 QSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS 360
Query: 361 LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII 420
LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
Sbjct: 361 LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII 420
Query: 421 LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL 480
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL
Sbjct: 421 LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQL 480
Query: 481 LQVIKKTETDMSLHPLLQEIYKDLY 505
LQVIKKTETDMSLHPLLQEIYKDLY
Sbjct: 481 LQVIKKTETDMSLHPLLQEIYKDLY 505
>gi|116284373 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 959 bits (2480), Expect = 0.0
Identities = 477/477 (100%), Positives = 477/477 (100%)
Query: 29 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP 88
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP
Sbjct: 1 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP 60
Query: 89 VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG 148
VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG
Sbjct: 61 VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG 120
Query: 149 FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI 208
FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
Sbjct: 121 FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI 180
Query: 209 RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK 268
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK
Sbjct: 181 RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK 240
Query: 269 TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA 328
TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA
Sbjct: 241 TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA 300
Query: 329 KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF 388
KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
Sbjct: 301 KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF 360
Query: 389 GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ 448
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ
Sbjct: 361 GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ 420
Query: 449 LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505
LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Sbjct: 421 LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|116284368 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 959 bits (2480), Expect = 0.0
Identities = 477/477 (100%), Positives = 477/477 (100%)
Query: 29 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP 88
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP
Sbjct: 1 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP 60
Query: 89 VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG 148
VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG
Sbjct: 61 VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG 120
Query: 149 FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI 208
FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
Sbjct: 121 FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI 180
Query: 209 RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK 268
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK
Sbjct: 181 RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK 240
Query: 269 TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA 328
TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA
Sbjct: 241 TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA 300
Query: 329 KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF 388
KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
Sbjct: 301 KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF 360
Query: 389 GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ 448
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ
Sbjct: 361 GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ 420
Query: 449 LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505
LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Sbjct: 421 LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|116284370 peroxisome proliferative activated receptor gamma
isoform 1 [Homo sapiens]
Length = 477
Score = 959 bits (2480), Expect = 0.0
Identities = 477/477 (100%), Positives = 477/477 (100%)
Query: 29 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP 88
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP
Sbjct: 1 MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP 60
Query: 89 VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG 148
VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG
Sbjct: 61 VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG 120
Query: 149 FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI 208
FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
Sbjct: 121 FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI 180
Query: 209 RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK 268
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK
Sbjct: 181 RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK 240
Query: 269 TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA 328
TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA
Sbjct: 241 TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA 300
Query: 329 KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF 388
KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
Sbjct: 301 KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF 360
Query: 389 GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ 448
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ
Sbjct: 361 GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ 420
Query: 449 LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505
LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Sbjct: 421 LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 477
>gi|5453940 peroxisome proliferative activated receptor, delta
isoform 1 [Homo sapiens]
Length = 441
Score = 516 bits (1329), Expect = e-146
Identities = 249/396 (62%), Positives = 319/396 (80%), Gaps = 4/396 (1%)
Query: 111 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 170
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
Query: 171 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 229
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
Query: 230 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 289
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Query: 290 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 349
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
Query: 350 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 409
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
Query: 410 SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTD 469
SDLA+FIA IIL GDRPGL+NV +E IQD +L+ALE L+ NHP++ LF KLLQKM D
Sbjct: 346 SDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMAD 405
Query: 470 LRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505
LRQ+VTEH Q++Q IKKTET+ SLHPLLQEIYKD+Y
Sbjct: 406 LRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY 441
>gi|50348666 peroxisome proliferative activated receptor, alpha
[Homo sapiens]
Length = 468
Score = 510 bits (1313), Expect = e-144
Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)
Query: 108 VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 167
+ PAS P + E PS +L IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 72 LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
Query: 168 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 226
RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
Query: 227 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 286
+ D + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++ PFVI+DM +L M
Sbjct: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
Query: 287 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 346
E + K + Q+KE +RIF CQ SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
Query: 347 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 406
KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
Query: 407 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 466
LDDSD+++F+A II GDRPGLLNV IE +Q+ ++ L L L+ NHP+ LF KLLQK
Sbjct: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
Query: 467 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505
M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
>gi|7549811 peroxisome proliferative activated receptor, alpha [Homo
sapiens]
Length = 468
Score = 510 bits (1313), Expect = e-144
Identities = 251/399 (62%), Positives = 315/399 (78%), Gaps = 3/399 (0%)
Query: 108 VEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTI 167
+ PAS P + E PS +L IECR+CGDKASG+HYGVHACEGCKGFFRRTI
Sbjct: 72 LSPASSPSSVTYPVVPGSVDESPSGALN-IECRICGDKASGYHYGVHACEGCKGFFRRTI 130
Query: 168 RLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEI-S 226
RLKL+YD+CD +C+I KK+RNKCQYCRF KCL+VGMSHNAIRFGRMP++EK KL AEI +
Sbjct: 131 RLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILT 190
Query: 227 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 286
+ D + E+ADL++LAK +Y++Y+K+F + K KAR IL+GK ++ PFVI+DM +L M
Sbjct: 191 CEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMA 250
Query: 287 EDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL 346
E + K + Q+KE +RIF CQ SVE V E+TE+AK+IPGF NLDLNDQVTLL
Sbjct: 251 EKTLVAKLVAN-GIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLL 309
Query: 347 KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALE 406
KYGV+E I+ ML+S+MNKDG+L++ G GF+TREFLKSLRKPF D MEPKF+FA+KFNALE
Sbjct: 310 KYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALE 369
Query: 407 LDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQK 466
LDDSD+++F+A II GDRPGLLNV IE +Q+ ++ L L L+ NHP+ LF KLLQK
Sbjct: 370 LDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQK 429
Query: 467 MTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY 505
M DLRQ+VTEH QL+Q+IKKTE+D +LHPLLQEIY+D+Y
Sbjct: 430 MADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY 468
>gi|29171750 peroxisome proliferative activated receptor, delta
isoform 2 [Homo sapiens]
Length = 361
Score = 401 bits (1030), Expect = e-112
Identities = 193/314 (61%), Positives = 251/314 (79%), Gaps = 4/314 (1%)
Query: 111 ASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLK 170
+SPP ++ Q+ + S + +ECRVCGDKASGFHYGVHACEGCKGFFRRTIR+K
Sbjct: 49 SSPPSLLDQLQM---GCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMK 105
Query: 171 LIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDI- 229
L Y++C+ +C+I KK+RNKCQYCRFQKCLA+GMSHNAIRFGRMP+AEK KL+A ++++
Sbjct: 106 LEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEG 165
Query: 230 DQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDK 289
Q NP+ ADL+A +KH+Y++Y+K+F +TK KAR+ILTGK + +PFVI+D+ +L E
Sbjct: 166 SQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKG 225
Query: 290 IKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYG 349
+ +K + KE+++ +F CQ +VE V+E+TE+AKSIP F +L LNDQVTLLKYG
Sbjct: 226 LVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYG 285
Query: 350 VHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDD 409
VHE I+ MLAS++NKDG+L++ G GF+TREFL+SLRKPF D +EPKFEFAVKFNALELDD
Sbjct: 286 VHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDD 345
Query: 410 SDLAIFIAVIILSG 423
SDLA+FIA IIL G
Sbjct: 346 SDLALFIAAIILCG 359
>gi|223718064 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 175 bits (444), Expect = 8e-44
Identities = 119/390 (30%), Positives = 195/390 (50%), Gaps = 42/390 (10%)
Query: 117 SEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-R 175
S ++ P P + C VC DK+SG+HYGV ACEGCKGFFRR+I+ ++Y
Sbjct: 66 SSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCH 125
Query: 176 CDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPE 235
D NC I+K +RN+CQYCR QKC VGMS ++R R +K+++ S+ L PE
Sbjct: 126 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR--NKKKKEVPKPECSESYTLTPE 183
Query: 236 SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHI 295
+ L + + ++ ++FP A L TT+ S
Sbjct: 184 VGE---LIEKVRKAHQETFP-----ALCQLGKYTTNNS---------------------- 213
Query: 296 TPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIY 355
EQ + I ++ S + + + E+AK +PGF L + DQ+TLLK +I+
Sbjct: 214 ---SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILI 270
Query: 356 TMLAS--LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLA 413
+ + +D + S+G +T + FG + F FA + LE+DD++
Sbjct: 271 LRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 327
Query: 414 IFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI 473
+ A+ ++ GDR L ++ +Q+ LL+AL++ ++ P +F K+L K+TDLR I
Sbjct: 328 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 387
Query: 474 VTEHVQLLQVIKKTETDMSLHPLLQEIYKD 503
+ + + + K E S+ PL+QE+ ++
Sbjct: 388 SAKGAERV-ITLKMEIPGSMPPLIQEMLEN 416
>gi|67459914 retinoic acid receptor, alpha isoform 2 [Homo sapiens]
Length = 457
Score = 175 bits (444), Expect = 8e-44
Identities = 119/390 (30%), Positives = 195/390 (50%), Gaps = 42/390 (10%)
Query: 117 SEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-R 175
S ++ P P + C VC DK+SG+HYGV ACEGCKGFFRR+I+ ++Y
Sbjct: 61 SSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCH 120
Query: 176 CDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPE 235
D NC I+K +RN+CQYCR QKC VGMS ++R R +K+++ S+ L PE
Sbjct: 121 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR--NKKKKEVPKPECSESYTLTPE 178
Query: 236 SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHI 295
+ L + + ++ ++FP A L TT+ S
Sbjct: 179 VGE---LIEKVRKAHQETFP-----ALCQLGKYTTNNS---------------------- 208
Query: 296 TPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIY 355
EQ + I ++ S + + + E+AK +PGF L + DQ+TLLK +I+
Sbjct: 209 ---SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILI 265
Query: 356 TMLAS--LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLA 413
+ + +D + S+G +T + FG + F FA + LE+DD++
Sbjct: 266 LRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 322
Query: 414 IFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI 473
+ A+ ++ GDR L ++ +Q+ LL+AL++ ++ P +F K+L K+TDLR I
Sbjct: 323 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 382
Query: 474 VTEHVQLLQVIKKTETDMSLHPLLQEIYKD 503
+ + + + K E S+ PL+QE+ ++
Sbjct: 383 SAKGAERV-ITLKMEIPGSMPPLIQEMLEN 411
>gi|4506419 retinoic acid receptor, alpha isoform 1 [Homo sapiens]
Length = 462
Score = 175 bits (444), Expect = 8e-44
Identities = 119/390 (30%), Positives = 195/390 (50%), Gaps = 42/390 (10%)
Query: 117 SEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-R 175
S ++ P P + C VC DK+SG+HYGV ACEGCKGFFRR+I+ ++Y
Sbjct: 66 SSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCH 125
Query: 176 CDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPE 235
D NC I+K +RN+CQYCR QKC VGMS ++R R +K+++ S+ L PE
Sbjct: 126 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDR--NKKKKEVPKPECSESYTLTPE 183
Query: 236 SADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHI 295
+ L + + ++ ++FP A L TT+ S
Sbjct: 184 VGE---LIEKVRKAHQETFP-----ALCQLGKYTTNNS---------------------- 213
Query: 296 TPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIY 355
EQ + I ++ S + + + E+AK +PGF L + DQ+TLLK +I+
Sbjct: 214 ---SEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILI 270
Query: 356 TMLAS--LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLA 413
+ + +D + S+G +T + FG + F FA + LE+DD++
Sbjct: 271 LRICTRYTPEQDTMTFSDG---LTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETG 327
Query: 414 IFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI 473
+ A+ ++ GDR L ++ +Q+ LL+AL++ ++ P +F K+L K+TDLR I
Sbjct: 328 LLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSI 387
Query: 474 VTEHVQLLQVIKKTETDMSLHPLLQEIYKD 503
+ + + + K E S+ PL+QE+ ++
Sbjct: 388 SAKGAERV-ITLKMEIPGSMPPLIQEMLEN 416
>gi|14916494 retinoic acid receptor, beta isoform 1 [Homo sapiens]
Length = 448
Score = 174 bits (442), Expect = 1e-43
Identities = 116/368 (31%), Positives = 191/368 (51%), Gaps = 42/368 (11%)
Query: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-RCDLNCRIHKKSRNKCQYCRFQK 197
C VC DK+SG+HYGV ACEGCKGFFRR+I+ +IY D NC I+K +RN+CQYCR QK
Sbjct: 81 CFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMIYTCHRDKNCVINKVTRNRCQYCRLQK 140
Query: 198 CLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLT 257
C VGMS ++R R + +KE E + + +A+L L + + ++ ++FP
Sbjct: 141 CFEVGMSKESVRNDR-NKKKKETSKQECTESYEM----TAELDDLTEKIRKAHQETFP-- 193
Query: 258 KAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRS 317
GK T S + +++ L ++ E+A
Sbjct: 194 ----SLCQLGKYTTNS-----------SADHRVRLD--LGLWDKFSELA----------- 225
Query: 318 VEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS--LMNKDGVLISEGQGF 375
+ + +I E+AK +PGF L + DQ+TLLK +I+ + + +D + S+G
Sbjct: 226 TKCIIKIVEFAKRLPGFTGLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDG--- 282
Query: 376 MTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIE 435
+T + FG + F FA + LE+DD++ + A+ ++ GDR L ++
Sbjct: 283 LTLNRTQMHNAGFGPLTDLVFTFANQLLPLEMDDTETGLLSAICLICGDRQDLEEPTKVD 342
Query: 436 DIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP 495
+Q+ LL+AL++ ++ P +F K+L K+TDLR I + + + + K E S+ P
Sbjct: 343 KLQEPLLEALKIYIRKRRPSKPHMFPKILMKITDLRSISAKGAERV-ITLKMEIPGSMPP 401
Query: 496 LLQEIYKD 503
L+QE+ ++
Sbjct: 402 LIQEMLEN 409
>gi|112181200 retinoic acid receptor, gamma isoform 2 [Homo sapiens]
Length = 443
Score = 173 bits (439), Expect = 3e-43
Identities = 113/368 (30%), Positives = 188/368 (51%), Gaps = 42/368 (11%)
Query: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-RCDLNCRIHKKSRNKCQYCRFQK 197
C VC DK+SG+HYGV +CEGCKGFFRR+I+ ++Y D NC I+K +RN+CQYCR QK
Sbjct: 79 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 138
Query: 198 CLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLT 257
C VGMS A+R R +K+++ E S D +L+P+ L L + ++ ++FP
Sbjct: 139 CFEVGMSKEAVRNDR--NKKKKEVKEEGSPDSYELSPQ---LEELITKVSKAHQETFP-- 191
Query: 258 KAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRS 317
GK T S + ++ + ++ +
Sbjct: 192 ----SLCQLGKYTTNSS------------------------ADHRVQLDLGLWDKFSELA 223
Query: 318 VEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS--LMNKDGVLISEGQGF 375
+ + +I E+AK +PGF L + DQ+TLLK +I+ + + +D + S+G
Sbjct: 224 TKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDG--- 280
Query: 376 MTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIE 435
+T + FG + F FA + LE+DD++ + A+ ++ GDR L + ++
Sbjct: 281 LTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVD 340
Query: 436 DIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP 495
+Q+ LL+AL L + P +F ++L K+TDLR I T+ + + K E + P
Sbjct: 341 KLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAE-RAITLKMEIPGPMPP 399
Query: 496 LLQEIYKD 503
L++E+ ++
Sbjct: 400 LIREMLEN 407
>gi|4506423 retinoic acid receptor, gamma isoform 1 [Homo sapiens]
Length = 454
Score = 173 bits (439), Expect = 3e-43
Identities = 113/368 (30%), Positives = 188/368 (51%), Gaps = 42/368 (11%)
Query: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-RCDLNCRIHKKSRNKCQYCRFQK 197
C VC DK+SG+HYGV +CEGCKGFFRR+I+ ++Y D NC I+K +RN+CQYCR QK
Sbjct: 90 CFVCNDKSSGYHYGVSSCEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQK 149
Query: 198 CLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLT 257
C VGMS A+R R +K+++ E S D +L+P+ L L + ++ ++FP
Sbjct: 150 CFEVGMSKEAVRNDR--NKKKKEVKEEGSPDSYELSPQ---LEELITKVSKAHQETFP-- 202
Query: 258 KAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRS 317
GK T S + ++ + ++ +
Sbjct: 203 ----SLCQLGKYTTNSS------------------------ADHRVQLDLGLWDKFSELA 234
Query: 318 VEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLAS--LMNKDGVLISEGQGF 375
+ + +I E+AK +PGF L + DQ+TLLK +I+ + + +D + S+G
Sbjct: 235 TKCIIKIVEFAKRLPGFTGLSIADQITLLKAACLDILMLRICTRYTPEQDTMTFSDG--- 291
Query: 376 MTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIE 435
+T + FG + F FA + LE+DD++ + A+ ++ GDR L + ++
Sbjct: 292 LTLNRTQMHNAGFGPLTDLVFAFAGQLLPLEMDDTETGLLSAICLICGDRMDLEEPEKVD 351
Query: 436 DIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHP 495
+Q+ LL+AL L + P +F ++L K+TDLR I T+ + + K E + P
Sbjct: 352 KLQEPLLEALRLYARRRRPSQPYMFPRMLMKITDLRGISTKGAE-RAITLKMEIPGPMPP 410
Query: 496 LLQEIYKD 503
L++E+ ++
Sbjct: 411 LIREMLEN 418
>gi|194294519 nuclear receptor subfamily 1, group H, member 3
isoform c [Homo sapiens]
Length = 402
Score = 160 bits (405), Expect = 3e-39
Identities = 115/399 (28%), Positives = 188/399 (47%), Gaps = 33/399 (8%)
Query: 111 ASPPYYSEKTQLY-NKPHEEPSNSLMAIE-CRVCGDKASGFHYGVHACEGCKGFFRRTIR 168
A PP SE T++ K + P+ ++ E C VCGDKASGFHY V +CEGCKGFFRR++
Sbjct: 25 AEPP--SEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSV- 81
Query: 169 LKLIYDRCDL--NCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEIS 226
+K + C +C + R KCQ CR +KC GM + + +K K E
Sbjct: 82 IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQ 141
Query: 227 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 286
+ L P ++ + L + A + +D+ + M
Sbjct: 142 AHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHS 201
Query: 287 ED--KIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT 344
+ + +F H T L ++ +VQEI ++AK +PGF+ L DQ+
Sbjct: 202 REARQQRFAHFTEL------------------AIVSVQEIVDFAKQLPGFLQLSREDQIA 243
Query: 345 LLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKF 402
LLK E++ + N + + + + +F K+ + +F+ P FEF+
Sbjct: 244 LLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQV--EFINPIFEFSRAM 301
Query: 403 NALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAK 462
N L+L+D++ A+ IA+ I S DRP + + +E +Q ++AL + ++HP +F +
Sbjct: 302 NELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPR 361
Query: 463 LLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIY 501
+L K+ LR + + H + QV D L PLL EI+
Sbjct: 362 MLMKLVSLRTLSSVHSE--QVFALRLQDKKLPPLLSEIW 398
>gi|194294517 nuclear receptor subfamily 1, group H, member 3
isoform a [Homo sapiens]
Length = 447
Score = 160 bits (405), Expect = 3e-39
Identities = 115/399 (28%), Positives = 188/399 (47%), Gaps = 33/399 (8%)
Query: 111 ASPPYYSEKTQLY-NKPHEEPSNSLMAIE-CRVCGDKASGFHYGVHACEGCKGFFRRTIR 168
A PP SE T++ K + P+ ++ E C VCGDKASGFHY V +CEGCKGFFRR++
Sbjct: 70 AEPP--SEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSV- 126
Query: 169 LKLIYDRCDL--NCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEIS 226
+K + C +C + R KCQ CR +KC GM + + +K K E
Sbjct: 127 IKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQ 186
Query: 227 SDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMG 286
+ L P ++ + L + A + +D+ + M
Sbjct: 187 AHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHS 246
Query: 287 ED--KIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT 344
+ + +F H T L ++ +VQEI ++AK +PGF+ L DQ+
Sbjct: 247 REARQQRFAHFTEL------------------AIVSVQEIVDFAKQLPGFLQLSREDQIA 288
Query: 345 LLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKF 402
LLK E++ + N + + + + +F K+ + +F+ P FEF+
Sbjct: 289 LLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQV--EFINPIFEFSRAM 346
Query: 403 NALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAK 462
N L+L+D++ A+ IA+ I S DRP + + +E +Q ++AL + ++HP +F +
Sbjct: 347 NELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPR 406
Query: 463 LLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIY 501
+L K+ LR + + H + QV D L PLL EI+
Sbjct: 407 MLMKLVSLRTLSSVHSE--QVFALRLQDKKLPPLLSEIW 443
>gi|5902068 retinoid X receptor, gamma isoform a [Homo sapiens]
Length = 463
Score = 155 bits (393), Expect = 6e-38
Identities = 114/381 (29%), Positives = 180/381 (47%), Gaps = 54/381 (14%)
Query: 124 NKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-RCDLNCRI 182
N P P SL+ C +CGD++SG HYGV++CEGCKGFF+RTIR LIY R + +C I
Sbjct: 125 NYPSTSPG-SLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLI 183
Query: 183 HKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRAL 242
K+ RN+CQYCR+QKCL +GM A++ R E+ + AE ++ + P
Sbjct: 184 DKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMP-------- 235
Query: 243 AKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQS 302
+ + ++ + P T++ + T D + ++ DK F
Sbjct: 236 VERILEAELAVEPKTESYGDMNMENSTND-------PVTNICHAADKQLF---------- 278
Query: 303 KEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLA--S 360
+ E+AK IP F +L L DQV LL+ G +E++ + S
Sbjct: 279 --------------------TLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRS 318
Query: 361 LMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII 420
+ +DG+L++ G + R S F E K +++D S+L A+++
Sbjct: 319 VSVQDGILLATGL-HVHRSSAHSAGVG-SIFDRVLTELVSKMKDMQMDKSELGCLRAIVL 376
Query: 421 LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI---VTEH 477
+ D GL N +E +++ + LE K +PE FAKLL ++ LR I EH
Sbjct: 377 FNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEH 436
Query: 478 VQLLQVIKKTETDMSLHPLLQ 498
+ ++I T D L +L+
Sbjct: 437 LFFFKLIGDTPIDTFLMEMLE 457
>gi|4506755 retinoid X receptor, alpha [Homo sapiens]
Length = 462
Score = 150 bits (378), Expect = 3e-36
Identities = 107/367 (29%), Positives = 176/367 (47%), Gaps = 52/367 (14%)
Query: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-RCDLNCRIHKKSRNKCQYCRFQK 197
C +CGD++SG HYGV++CEGCKGFF+RT+R L Y R + +C I K+ RN+CQYCR+QK
Sbjct: 135 CAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQK 194
Query: 198 CLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLT 257
CLA+GM A++ R ++ + E +S ++ P + + ++ + P T
Sbjct: 195 CLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMP--------VERILEAELAVEPKT 246
Query: 258 KAKARAIL-TGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFR 316
+ A + ++ P + ++ DK F
Sbjct: 247 ETYVEANMGLNPSSPNDP-----VTNICQAADKQLF------------------------ 277
Query: 317 SVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLA--SLMNKDGVLISEGQG 374
+ E+AK IP F L L+DQV LL+ G +E++ + S+ KDG+L++ G
Sbjct: 278 ------TLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGL- 330
Query: 375 FMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI 434
+ R S F E K +++D ++L A+++ + D GL N +
Sbjct: 331 HVHRNSAHSAGVG-AIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEV 389
Query: 435 EDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI---VTEHVQLLQVIKKTETDM 491
E +++ + +LE K +PE FAKLL ++ LR I EH+ ++I T D
Sbjct: 390 EALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDT 449
Query: 492 SLHPLLQ 498
L +L+
Sbjct: 450 FLMEMLE 456
>gi|85362735 nuclear receptor subfamily 1, group H, member 2 [Homo
sapiens]
Length = 461
Score = 146 bits (369), Expect = 4e-35
Identities = 111/391 (28%), Positives = 178/391 (45%), Gaps = 19/391 (4%)
Query: 125 KPHEEPSNSLMAIE-CRVCGDKASGFHYGVHACEGCKGFFRRTI---RLKLIYDRCDLNC 180
K + P+ ++ E CRVCGDKASGFHY V +CEGCKGFFRR++ + R C
Sbjct: 72 KRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTC 131
Query: 181 RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFG---RMPQAEKEKLLAEISSDIDQLNPESA 237
++ R KCQ CR +KC GM + R + K++ S + P+ +
Sbjct: 132 QMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQQESQSQSQSPVGPQGS 191
Query: 238 DLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKH--- 294
A ++ + + + T +I + + + +K F
Sbjct: 192 SSSASGPGASPGGSEAGSQGSGEGEGV---QLTAAQELMIQQLVAAQLQCNKRSFSDQPK 248
Query: 295 ITP----LQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV 350
+TP QS++ + F ++ +VQEI ++AK +PGF+ L DQ+ LLK
Sbjct: 249 VTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKAST 308
Query: 351 HEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDS 410
EI+ A N + I+ + F + +F+ P FEF+ L LDD+
Sbjct: 309 IEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDA 368
Query: 411 DLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDL 470
+ A+ IA+ I S DRP + +E +Q ++AL ++ P+ F ++L K+ L
Sbjct: 369 EYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSL 428
Query: 471 RQIVTEHVQLLQVIKKTETDMSLHPLLQEIY 501
R + + H + QV D L PLL EI+
Sbjct: 429 RTLSSVHSE--QVFALRLQDKKLPPLLSEIW 457
>gi|4826980 nuclear receptor subfamily 1, group H, member 4 [Homo
sapiens]
Length = 472
Score = 145 bits (367), Expect = 6e-35
Identities = 107/365 (29%), Positives = 171/365 (46%), Gaps = 24/365 (6%)
Query: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDL--NCRIHKKSRNKCQYCRFQ 196
C VCGD+ASG+HY CEGCKGFFRR+I +Y +C NC + R KCQ CR +
Sbjct: 127 CVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVY-KCKNGGNCVMDMYMRRKCQECRLR 185
Query: 197 KCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPL 256
KC +GM + Q + ++L + DQ E ++ R L +
Sbjct: 186 KCKEMGMLAECLL--TEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQ----------VT 233
Query: 257 TKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFR 316
+ K+ T T D+ + + M+S + + +E S E I
Sbjct: 234 STTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEM--- 290
Query: 317 SVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFM 376
+ VQ + E+ K +PGF LD DQ+ LLK E ++ A + NK + G +
Sbjct: 291 ATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKK---LPSGHSDL 347
Query: 377 TREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIED 436
E +++ +++ P F F L++ + A+ A++ILS DR + + + +E
Sbjct: 348 LEERIRNSGIS-DEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK 406
Query: 437 IQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPL 496
+Q+ LL L+ K++ PE+ Q FA LL ++T+LR H ++L + D PL
Sbjct: 407 LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEML--MSWRVNDHKFTPL 464
Query: 497 LQEIY 501
L EI+
Sbjct: 465 LCEIW 469
>gi|14702164 nuclear receptor subfamily 1, group I, member 2 isoform
3 [Homo sapiens]
Length = 397
Score = 139 bits (350), Expect = 6e-33
Identities = 104/377 (27%), Positives = 172/377 (45%), Gaps = 39/377 (10%)
Query: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLN---CRIHKKSRNKCQYCRF 195
CRVCGDKA+G+H+ V CEGCKGFFRR ++ RC C I +K+R +CQ CR
Sbjct: 41 CRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARL-RCPFRKGACEITRKTRRQCQACRL 99
Query: 196 QKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNP-----ESADLRALAKHLYDSY 250
+KCL GM I + E+ L+ S+ P + + R + + L D+
Sbjct: 100 RKCLESGMKKEMIMSDEAVE-ERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQ 158
Query: 251 IKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIF 310
+K+F T S F + ++ + GED + + P KE+ +
Sbjct: 159 MKTF--------------DTTFSHFKNFRVSLQLRGEDGSVWNYKPPADSGGKEI-FSLL 203
Query: 311 QGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLIS 370
S + I +AK I F +L + DQ++LLK E+ ++ N +
Sbjct: 204 PHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFN------A 257
Query: 371 EGQGFMTREFLKSLRKPFGDF----MEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRP 426
E + L G F +EP +F L+L + + + A+ + S DRP
Sbjct: 258 ETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRP 317
Query: 427 GLLNVKPIEDIQDNLLQALELQLKLNHPESSQ--LFAKLLQKMTDLRQIVTEHVQLLQVI 484
G+L + ++ +Q+ L+ ++ N P+ + LF K++ +T+LR I +H Q L I
Sbjct: 318 GVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRI 377
Query: 485 KKTETDMSLHPLLQEIY 501
+ + PL+QE++
Sbjct: 378 QDIHPFAT--PLMQELF 392
>gi|13430848 nuclear receptor subfamily 1, group D, member 1 [Homo
sapiens]
Length = 614
Score = 135 bits (340), Expect = 9e-32
Identities = 60/101 (59%), Positives = 81/101 (80%), Gaps = 2/101 (1%)
Query: 135 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 192
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y RC + NC I + +RN+CQ
Sbjct: 128 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQ 187
Query: 193 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLN 233
CRF+KCL+VGMS +A+RFGR+P+ EK+++LAE+ S ++ N
Sbjct: 188 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLAN 228
Score = 108 bits (271), Expect = 9e-24
Identities = 62/163 (38%), Positives = 96/163 (58%), Gaps = 3/163 (1%)
Query: 320 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN-KDGVLISEGQGFMTR 378
AV+E+ E+AK IPGF +L +DQVTLLK G E++ ASL N KD ++ + +
Sbjct: 446 AVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSL 505
Query: 379 EFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQ 438
+ L ++ GD + F+F+ K N+L L + +L +F AV+++S DR G+ N +E +Q
Sbjct: 506 QELGAMG--MGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQ 563
Query: 439 DNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLL 481
+ LL+AL + N P + F KLL K+ DLR + H + L
Sbjct: 564 ETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKL 606
>gi|7657395 photoreceptor-specific nuclear receptor isoform b [Homo
sapiens]
Length = 410
Score = 134 bits (338), Expect = 1e-31
Identities = 117/394 (29%), Positives = 189/394 (47%), Gaps = 37/394 (9%)
Query: 128 EEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLN---CRIHK 184
E+P+ +++CRVCGD +SG HYG++AC GC GFF+R++R +LIY RC + C + K
Sbjct: 36 EDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIY-RCQVGAGMCPVDK 94
Query: 185 KSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAK 244
RN+CQ CR +KCL GM+ +A++ R P++ + L + S+ + PES L A
Sbjct: 95 AHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTES-RPES--LVAPPA 151
Query: 245 HLYDSYIKSFPLTKAKA------RAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPL 298
S P++ A+A +++T +T K D N + D +F +P
Sbjct: 152 PAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDP-EFPS-SPY 209
Query: 299 QEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHE--IIYT 356
S I + S + ++AK++P F +L DQV LL+ E ++
Sbjct: 210 SSSSPCGLDSIHE----TSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGA 265
Query: 357 MLASLMNKDGVLI-----SEGQGFMTREFLKSLRKPFGDFMEPKF--EFAVKFNALELDD 409
+ SL L+ S G R L S ME + E +F AL +D
Sbjct: 266 IQWSLPLDSCPLLAPPEASAAGGAQGRLTLAS--------METRVLQETISRFRALAVDP 317
Query: 410 SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTD 469
++ A A+++ + GL + + +E +QD L K +HP F KLL +
Sbjct: 318 TEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPS 377
Query: 470 LRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKD 503
LR I E ++LL +KT + + LL +++K+
Sbjct: 378 LRFITAERIELL-FFRKTIGNTPMEKLLCDMFKN 410
>gi|14149746 nuclear receptor subfamily 2, group F, member 2 isoform
a [Homo sapiens]
Length = 414
Score = 133 bits (334), Expect = 4e-31
Identities = 102/377 (27%), Positives = 163/377 (43%), Gaps = 47/377 (12%)
Query: 126 PHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYD-RCDLNCRIHK 184
P + IEC VCGDK+SG HYG CEGCK FF+R++R L Y R + NC I +
Sbjct: 66 PGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQ 125
Query: 185 KSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAK 244
RN+CQYCR +KCL VGM A++ GRMP + +++ D LN
Sbjct: 126 HHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNG-DPLN----------- 173
Query: 245 HLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKE 304
SY+ + +A T + G ++ +I ++ +
Sbjct: 174 --CHSYLSGYISLLLRAEPYPTSR----------------FGSQCMQPNNIMGIENICEL 215
Query: 305 VAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASL-MN 363
A +F E+A++IP F +L + DQV LL+ E+ A M
Sbjct: 216 AARMLFSA------------VEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMP 263
Query: 364 KDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSG 423
+ G F D + E K AL +D ++ + A+++ +
Sbjct: 264 LHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTS 323
Query: 424 DRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQI---VTEHVQL 480
D GL +V +E +Q+ ALE ++ +P F KLL ++ LR + V E +
Sbjct: 324 DACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFF 383
Query: 481 LQVIKKTETDMSLHPLL 497
++++ KT + + +L
Sbjct: 384 VRLVGKTPIETLIRDML 400
>gi|224177493 nuclear receptor subfamily 1, group D, member 2
isoform 2 [Homo sapiens]
Length = 504
Score = 132 bits (332), Expect = 7e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 135 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 192
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 24 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 83
Query: 193 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 227
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 84 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 118
Score = 117 bits (292), Expect = 3e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 320 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 377
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 337 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 396
Query: 378 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 437
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 397 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 453
Query: 438 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 485
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 454 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 501
>gi|224177491 nuclear receptor subfamily 1, group D, member 2
isoform 1 [Homo sapiens]
Length = 579
Score = 132 bits (332), Expect = 7e-31
Identities = 57/95 (60%), Positives = 77/95 (81%), Gaps = 2/95 (2%)
Query: 135 MAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRC--DLNCRIHKKSRNKCQY 192
M + C+VCGD ASGFHYGVHACEGCKGFFRR+I+ + Y +C + NC I + +RN+CQ
Sbjct: 99 MVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKKCLKNENCSIMRMNRNRCQQ 158
Query: 193 CRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISS 227
CRF+KCL+VGMS +A+RFGR+P+ EK+++L E+ S
Sbjct: 159 CRFKKCLSVGMSRDAVRFGRIPKREKQRMLIEMQS 193
Score = 117 bits (292), Expect = 3e-26
Identities = 65/168 (38%), Positives = 100/168 (59%), Gaps = 5/168 (2%)
Query: 320 AVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMN--KDGVLISEGQGFMT 377
AV+E+ E+AK IPGF +L +DQV LLK G E++ ASL + + V G+ +
Sbjct: 412 AVKEVVEFAKRIPGFRDLSQHDQVNLLKAGTFEVLMVRFASLFDAKERTVTFLSGKKYSV 471
Query: 378 REFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDI 437
+ L S+ GD + FEF+ K NAL+L D ++++F AV+++S DR G+ NV +E +
Sbjct: 472 DD-LHSMGA--GDLLNSMFEFSEKLNALQLSDEEMSLFTAVVLVSADRSGIENVNSVEAL 528
Query: 438 QDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 485
Q+ L++AL + NHP + +F KLL K+ DLR + H + L K
Sbjct: 529 QETLIRALRTLIMKNHPNEASIFTKLLLKLPDLRSLNNMHSEELLAFK 576
>gi|5032173 nuclear receptor subfamily 2, group F, member 1 [Homo
sapiens]
Length = 423
Score = 131 bits (329), Expect = 2e-30
Identities = 111/393 (28%), Positives = 173/393 (44%), Gaps = 51/393 (12%)
Query: 110 PASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRL 169
PA+P +K Q P S IEC VCGDK+SG HYG CEGCK FF+R++R
Sbjct: 61 PATPGTAGDKGQ--GPPGS--GQSQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRR 116
Query: 170 KLIYD-RCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSD 228
L Y R + NC I + RN+CQYCR +KCL VGM A++ GRMP + +++
Sbjct: 117 NLTYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPNPGQYALTNG 176
Query: 229 IDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGED 288
D LN Y+ + +A T + G
Sbjct: 177 -DPLNGH-------------CYLSGYISLLLRAEPYPTSR----------------YGSQ 206
Query: 289 KIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKY 348
++ +I + E E+A R+ F +V E+A++IP F +L + DQV+LL+
Sbjct: 207 CMQPNNIMGI-ENICELAARLL----FSAV-------EWARNIPFFPDLQITDQVSLLRL 254
Query: 349 GVHEIIYTMLASL-MNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALEL 407
E+ A M + G F D + E K AL +
Sbjct: 255 TWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHV 314
Query: 408 DDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKM 467
D ++ + A+++ + D GL + IE +Q+ ALE ++ +P F KLL ++
Sbjct: 315 DSAEYSCLKAIVLFTSDACGLSDAAHIESLQEKSQCALEEYVRSQYPNQPSRFGKLLLRL 374
Query: 468 TDLRQI---VTEHVQLLQVIKKTETDMSLHPLL 497
LR + V E + ++++ KT + + +L
Sbjct: 375 PSLRTVSSSVIEQLFFVRLVGKTPIETLIRDML 407
>gi|27894344 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 125 bits (315), Expect = 7e-29
Identities = 110/378 (29%), Positives = 176/378 (46%), Gaps = 63/378 (16%)
Query: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIY-DRCDLNCRIHKKSRNKCQYCRFQK 197
C VCGD AS HYGV CEGCKGFF+RT++ Y + +C + K+ RN+CQ+CRFQK
Sbjct: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
Query: 198 CLAVGMSHNAIRF-------GRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSY 250
CLAVGM +R GR+P K+ P A L L ++
Sbjct: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQ--------------PPDASPANLLTSLVRAH 372
Query: 251 IKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIF 310
+ S P T AK D KF+ + L KE A +
Sbjct: 373 LDSGPST-AKL--------------------------DYSKFQELV-LPHFGKEDAGDVQ 404
Query: 311 QGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNK-DGVLI 369
Q S +++ I ++A+ IPGF L DQ LL+ E+ LA +G LI
Sbjct: 405 QFYDLLS-GSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLI 463
Query: 370 SEGQGFMTREFLKSLR--KPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPG 427
F + L L+ + FGD+++ F+ ++L +D A A+++++ DR G
Sbjct: 464 -----FCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHG 517
Query: 428 LLNVKPIEDIQDNLLQALE--LQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 485
L + +E++Q+ + L+ + P+ + ++LL K+ +LR + T+ +Q + +
Sbjct: 518 LQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYL- 576
Query: 486 KTETDMSLHPLLQEIYKD 503
K E + P++ +I+ D
Sbjct: 577 KLEDLVPPPPIIDKIFMD 594
>gi|21361342 nuclear receptor subfamily 4, group A, member 1 [Homo
sapiens]
Length = 598
Score = 125 bits (315), Expect = 7e-29
Identities = 110/378 (29%), Positives = 176/378 (46%), Gaps = 63/378 (16%)
Query: 139 CRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIY-DRCDLNCRIHKKSRNKCQYCRFQK 197
C VCGD AS HYGV CEGCKGFF+RT++ Y + +C + K+ RN+CQ+CRFQK
Sbjct: 267 CAVCGDNASCQHYGVRTCEGCKGFFKRTVQKNAKYICLANKDCPVDKRRRNRCQFCRFQK 326
Query: 198 CLAVGMSHNAIRF-------GRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSY 250
CLAVGM +R GR+P K+ P A L L ++
Sbjct: 327 CLAVGMVKEVVRTDSLKGRRGRLPSKPKQ--------------PPDASPANLLTSLVRAH 372
Query: 251 IKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIF 310
+ S P T AK D KF+ + L KE A +
Sbjct: 373 LDSGPST-AKL--------------------------DYSKFQELV-LPHFGKEDAGDVQ 404
Query: 311 QGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNK-DGVLI 369
Q S +++ I ++A+ IPGF L DQ LL+ E+ LA +G LI
Sbjct: 405 QFYDLLS-GSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPGEGKLI 463
Query: 370 SEGQGFMTREFLKSLR--KPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPG 427
F + L L+ + FGD+++ F+ ++L +D A A+++++ DR G
Sbjct: 464 -----FCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSALVLIT-DRHG 517
Query: 428 LLNVKPIEDIQDNLLQALE--LQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIK 485
L + +E++Q+ + L+ + P+ + ++LL K+ +LR + T+ +Q + +
Sbjct: 518 LQEPRRVEELQNRIASCLKEHVAAVAGEPQPASCLSRLLGKLPELRTLCTQGLQRIFYL- 576
Query: 486 KTETDMSLHPLLQEIYKD 503
K E + P++ +I+ D
Sbjct: 577 KLEDLVPPPPIIDKIFMD 594
>gi|5453822 nuclear receptor subfamily 4, group A, member 2 [Homo
sapiens]
Length = 598
Score = 124 bits (311), Expect = 2e-28
Identities = 109/380 (28%), Positives = 171/380 (45%), Gaps = 62/380 (16%)
Query: 120 TQLYNKPHE-EPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIY-DRCD 177
TQ+ + P PSN + C VCGD A+ HYGV CEGCKGFF+RT++ Y +
Sbjct: 246 TQVPSPPSRGSPSNEGL---CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLAN 302
Query: 178 LNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRF-------GRMPQAEKEKLLAEISSDID 230
NC + K+ RN+CQYCRFQKCLAVGM +R GR+P K +
Sbjct: 303 KNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKS------PQEPS 356
Query: 231 QLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKI 290
+P + + AL + DS L ++ +A + + M G+D
Sbjct: 357 PPSPPVSLISALVRAHVDSNPAMTSLDYSRFQA---------------NPDYQMSGDDTQ 401
Query: 291 KFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGV 350
+ L S E+ I +A+ IPGF +L DQ L +
Sbjct: 402 HIQQFYDLLTGSMEI------------------IRGWAEKIPGFADLPKADQDLLFESAF 443
Query: 351 HEIIYTMLASLMNK-DGVLISEGQGFMTREFLKSLR--KPFGDFMEPKFEFAVKFNALEL 407
E+ LA N +G LI F L L+ + FG++++ EF+ + +
Sbjct: 444 LELFVLRLAYRSNPVEGKLI-----FCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNI 498
Query: 408 DDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHP--ESSQLFAKLLQ 465
D S + IA + + +R GL K +E++Q+ ++ L+ + N+ +KLL
Sbjct: 499 DISAFSC-IAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVTFNNGGLNRPNYLSKLLG 557
Query: 466 KMTDLRQIVTEHVQLLQVIK 485
K+ +LR + T+ +Q + +K
Sbjct: 558 KLPELRTLCTQGLQRIFYLK 577
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.136 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,689,143
Number of Sequences: 37866
Number of extensions: 748600
Number of successful extensions: 2487
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 115
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2093
Number of HSP's gapped (non-prelim): 231
length of query: 505
length of database: 18,247,518
effective HSP length: 107
effective length of query: 398
effective length of database: 14,195,856
effective search space: 5649950688
effective search space used: 5649950688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.