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Search of human proteins with 20302168
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20302168 toll-like receptor 8 [Homo sapiens]
(1041 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20302168 toll-like receptor 8 [Homo sapiens] 2092 0.0
gi|7706093 toll-like receptor 7 [Homo sapiens] 807 0.0
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 554 e-157
gi|4507531 toll-like receptor 3 [Homo sapiens] 192 1e-48
gi|16751843 toll-like receptor 5 [Homo sapiens] 179 9e-45
gi|19718734 toll-like receptor 2 [Homo sapiens] 167 4e-41
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 166 1e-40
gi|41350337 toll-like receptor 1 [Homo sapiens] 159 2e-38
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 146 9e-35
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 146 9e-35
gi|20143971 toll-like receptor 6 [Homo sapiens] 146 1e-34
gi|11321571 slit homolog 3 [Homo sapiens] 130 6e-30
gi|4759146 slit homolog 2 [Homo sapiens] 114 5e-25
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 110 5e-24
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 110 5e-24
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 109 2e-23
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 109 2e-23
gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens] 107 4e-23
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 104 4e-22
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 103 1e-21
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 102 2e-21
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 102 2e-21
gi|45505137 podocan [Homo sapiens] 102 2e-21
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 100 5e-21
gi|225579152 insulin-like growth factor binding protein, acid la... 100 1e-20
gi|4826772 insulin-like growth factor binding protein, acid labi... 100 1e-20
gi|167555127 CD180 molecule [Homo sapiens] 99 2e-20
gi|5901992 keratocan [Homo sapiens] 99 2e-20
gi|41349454 proline arginine-rich end leucine-rich repeat protei... 99 2e-20
gi|4506041 proline arginine-rich end leucine-rich repeat protein... 99 2e-20
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 2092 bits (5421), Expect = 0.0
Identities = 1041/1041 (100%), Positives = 1041/1041 (100%)
Query: 1 MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT 60
MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT
Sbjct: 1 MENMFLQSSMLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQT 60
Query: 61 VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA 120
VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA
Sbjct: 61 VGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGA 120
Query: 121 FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN 180
FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN
Sbjct: 121 FLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN 180
Query: 181 CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE 240
CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE
Sbjct: 181 CYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEE 240
Query: 241 DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR 300
DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR
Sbjct: 241 DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR 300
Query: 301 KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS 360
KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS
Sbjct: 301 KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS 360
Query: 361 RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL 420
RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL
Sbjct: 361 RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL 420
Query: 421 EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA 480
EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA
Sbjct: 421 EIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCA 480
Query: 481 AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN 540
AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN
Sbjct: 481 AYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNN 540
Query: 541 RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT 600
RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT
Sbjct: 541 RLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLT 600
Query: 601 DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL 660
DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL
Sbjct: 601 DKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFL 660
Query: 661 NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS 720
NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS
Sbjct: 661 NLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLS 720
Query: 721 HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI 780
HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI
Sbjct: 721 HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDI 780
Query: 781 GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT 840
GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT
Sbjct: 781 GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITT 840
Query: 841 MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE 900
MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE
Sbjct: 841 MVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINE 900
Query: 901 LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF 960
LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF
Sbjct: 901 LRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAF 960
Query: 961 YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN 1020
YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN
Sbjct: 961 YLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRN 1020
Query: 1021 VVLTENDSRYNNMYVDSIKQY 1041
VVLTENDSRYNNMYVDSIKQY
Sbjct: 1021 VVLTENDSRYNNMYVDSIKQY 1041
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 807 bits (2085), Expect = 0.0
Identities = 439/1023 (42%), Positives = 625/1023 (61%), Gaps = 17/1023 (1%)
Query: 30 FSRSYPCDEKKQ--NDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQ 87
F ++ PCD + VI +C+++ L E+P + T L L+ N I I+ SF L
Sbjct: 30 FPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLD 89
Query: 88 NLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPES 147
+L +I+ N + L I +F L L+ L L+ NQL +IP GLP S
Sbjct: 90 HLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPS 149
Query: 148 LTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKT-NIEDGVFETLTNLELL 206
L LSL NNI++I KE ++ L N++ LYL NCY+ C + +IE F LT L++L
Sbjct: 150 LQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVL 209
Query: 207 SLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFP 266
SL N+++ VP LPS+L +L+L N I I E+DF L L +LDLSGNCPRC+NAPFP
Sbjct: 210 SLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFP 269
Query: 267 CVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGE 326
C PC + + I AF LT+L+ L L S SL+ + WFKN+ L+ LDL N+L E
Sbjct: 270 CAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKE 329
Query: 327 IASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDD 386
I FL LP L LDLSFN+ Y +N+S+ FS L SL+ L +RGYVF+EL+ +
Sbjct: 330 IGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFN 389
Query: 387 FQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSS- 445
PL L NL ++LG NFIK + +F+ F L++I LS N+ISP + + +++
Sbjct: 390 LSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNAR 449
Query: 446 ----SFQRHIRKRRSTDFEFDPHSNFYHFTRP-----LIKPQCAAYGKALDLSLNSIFFI 496
S++ + ++ F +D ++ F + C YG+ LDLS NSIFF+
Sbjct: 450 TSVESYEPQVLEQLHY-FRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFV 508
Query: 497 GPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDL 556
+ F++L + CLNLS N +Q L+G+EF + ++YLD +NNRLD +++A EL L
Sbjct: 509 KSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKL 568
Query: 557 EVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFS 616
EVLD+S NSHYF+ G+TH L F +N L+ L ++ N+I + T + +ES+SL L F
Sbjct: 569 EVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSR-TMESESLRTLEFR 627
Query: 617 GNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNML 676
GN LD+LW + DNRY+ +FK L L LD+S N L +P+ F +P +L L + N L
Sbjct: 628 GNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGL 687
Query: 677 KFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVS 736
K F+W LQ LE LDL N+L + + LS+ + SL+ L+L +N+I L FL +
Sbjct: 688 KSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAF 747
Query: 737 SLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIP 796
L++LDLSSN ++ I K++ L ML LH N F CTCD F W++ H V IP
Sbjct: 748 QLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVN-HTEVTIP 806
Query: 797 RLV-DVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWD 855
L DV C PG +G+S++SL+L TC D+T +ILF + ++ +M+ A HL++WD
Sbjct: 807 YLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWD 866
Query: 856 VWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLL 915
VW+IY+ C AK+KGY+ L + YDA+I YDTKD +VT+WV+ EL LE+ R+K+ L
Sbjct: 867 VWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNL 926
Query: 916 CLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVI 975
CLEERDW PG +++NL QSI SKKTVFV+T KYAK+ NFK AFYL+ QRLMDE +DVI
Sbjct: 927 CLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVI 986
Query: 976 IFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVVLTENDSRYNNMYV 1035
I I LE Q S++L+LR+R+C SS+L+WP NP+A FWQ L+N + T+N Y+ ++
Sbjct: 987 ILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFK 1046
Query: 1036 DSI 1038
+++
Sbjct: 1047 ETV 1049
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 554 bits (1427), Expect = e-157
Identities = 353/979 (36%), Positives = 524/979 (53%), Gaps = 27/979 (2%)
Query: 65 VTELDLSDNFITHITNESFQGLQNLTKINLNHN-PNVQHQNGNPGIQSNGLNITDGAFLN 123
VT L LS N I H+ + F L +L +NL N P V +P + I FL
Sbjct: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPV---GLSPMHFPCHMTIEPSTFLA 121
Query: 124 LKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYF 183
+ L EL L N + +P+ LP+SL LSL NI + ++ L L+ L++ NCY+
Sbjct: 122 VPTLEELNLSYNNIMTVPA-LPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
Query: 184 NKVCEKT-NIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDF 242
C + + G L NL LSL +N+L+ VP LPSSL L LS +I ++ ED
Sbjct: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240
Query: 243 KGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKI 302
L L +LD+ GNC RC +AP PC+ C + F +L++L L L +SL +
Sbjct: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFP-QLHPDTFSHLSRLEGLVLKDSSLSWL 299
Query: 303 NAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRN 362
NA+WF+ + +L+VLDL N+L I L +L L+LSFNY K H++++ +
Sbjct: 300 NASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPS 359
Query: 363 FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEI 422
F L++L+ L + G F+ L E +PL +LP L T+ L +NFI Q +F+ F L
Sbjct: 360 FGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRY 419
Query: 423 IYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAY 482
+ LS+NRIS + T + ++ D S+ +P C+
Sbjct: 420 VDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSS------EDFRPNCSTL 473
Query: 483 GKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL 542
LDLS N++ + P F L + CL LS N +Q ++G++F + ++ LDL++N+L
Sbjct: 474 NFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKL 533
Query: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
D + + TEL LE LDLSYNS F + GV H+ F+ + L+ L+L+HNNI++ +
Sbjct: 534 DLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQ 593
Query: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
L S SL L FSGN L +W + D Y+ F+GL L LDLS NRL + + NL
Sbjct: 594 -QLCSTSLRALDFSGNALGHMWAEGD-LYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNL 651
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHN 722
P SL L + DN L FF W L P+LE+LDL GN+L LT+ + LR L +S N
Sbjct: 652 PKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCN 711
Query: 723 RISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGD 782
IS + GF S+ L+ L+LS+N LKT++ S + L +L++ NP C C
Sbjct: 712 SISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASA-LQILDVSANPLHCACGAA- 769
Query: 783 FRRWMDEHLNVK--IPRLVD-VICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFIT 839
+MD L V+ +P L V C SPG +G SI + +L C+ + + F +
Sbjct: 770 ---FMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAV 826
Query: 840 TMVMLAALAHHLFYWDVWFIYNVCLAKV--KGYRSLSTSQTF-YDAYISYDTKDASVTDW 896
+ + + HHL WD+W+ +++CLA + +G +S YDA++ +D ++V DW
Sbjct: 827 ALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADW 886
Query: 897 VINELRYHLEESRDKNVL-LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWN 955
V NELR LEE R + L LCLEERDW PG + +NL S+ S+KT+FVL S
Sbjct: 887 VYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGL 946
Query: 956 FKTAFYLALQRLMDENMDVIIFILLEPVLQHSQYLRLRQRICKSSILQWPDNPKAEGLFW 1015
+ +F LA QRL+++ DV++ ++L P + S+Y+RLRQR+C+ S+L WP P + FW
Sbjct: 947 LRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFW 1006
Query: 1016 QTLRNVVLTENDSRYNNMY 1034
L + +N YN +
Sbjct: 1007 AQLGMALTRDNHHFYNRNF 1025
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 192 bits (488), Expect = 1e-48
Identities = 235/924 (25%), Positives = 397/924 (42%), Gaps = 96/924 (10%)
Query: 136 QLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDG 195
+L Q+P LP ++T L+L N + + +R L +L + +N + +E
Sbjct: 41 KLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTI-------SKLEPE 93
Query: 196 VFETLTNLELLSLSFNSLSHVPPK---LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLD 252
+ + L L++L+L N LS + K ++L +L L + I+ I F NL LD
Sbjct: 94 LCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLD 153
Query: 253 LSGNCPRCFNAPFPCVPCDGGASINID-RFAFQNLTQLRYLNLSSTSLRKINAAWFKNMP 311
LS N G +S + + +NL +L N +L+ F N
Sbjct: 154 LSHN---------------GLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSS 198
Query: 312 HLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLL---- 367
LK L+L N + E + G F + + G + ++ + + ++ L
Sbjct: 199 -LKKLELSSNQ-IKEFSPGCFHAI-----------GRLFGLFLNNVQLGPSLTEKLCLEL 245
Query: 368 ---SLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIY 424
S+R L L F L + NL+ ++L N + + F LE +
Sbjct: 246 ANTSIRNLSLSNSQLSTTSNTTFLGL-KWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFF 304
Query: 425 LSENRISPLVKDTRQSYANSS--SFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAY 482
L N I L + N + +R K+ S P + + F Q
Sbjct: 305 LEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQ-SISLASLPKIDDFSF-------QWLKC 356
Query: 483 GKALDLSLNSIFFIGPNQFENLPDIACLNLSAN-SNAQVLSGTEFSAIPH--VKYLDLTN 539
+ L++ N I I N F L ++ L+LS + ++ + L+ F ++ H + L+LT
Sbjct: 357 LEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTK 416
Query: 540 NRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTL 599
N++ + A + L LEVLDL N + G + + N+ + LS+N L
Sbjct: 417 NKISKIESDAFSWLGHLEVLDLGLNEIGQELTG-----QEWRGLENIFEIYLSYNKYLQL 471
Query: 600 TDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAF 659
T SL L+ R L N D + S F+ L+NLT LDLS N + +I N+
Sbjct: 472 TRNSFALVPSLQRLML---RRVALKNVDSSP--SPFQPLRNLTILDLSNNNIANI-NDDM 525
Query: 660 LNLPASLTELHINDNMLKFFNWT---------LLQQFPRLELLDLRGNKLLFLTDSLSDF 710
L L L + N L W L+ L +L+L N + +
Sbjct: 526 LEGLEKLEILDLQHNNLARL-WKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKD 584
Query: 711 TSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELH 770
L+ + L N ++ LP+ + SLK L+L NL+ ++ K L+ L++
Sbjct: 585 LFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGP-AFRNLTELDMR 643
Query: 771 GNPFECTCD-IGDFRRWMDEHLNVKIPRLVD-VICASPGDQRGKSIVSLELTTCVSDVTA 828
NPF+CTC+ I F W++E + IP L +C +P G + + ++C
Sbjct: 644 FNPFDCTCESIAWFVNWINE-THTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPF 702
Query: 829 VILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLS--TSQTFYDAYISY 886
+ F I + + L H W + F +NV + +V G++ + T Q Y AYI +
Sbjct: 703 ELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIH 762
Query: 887 DTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVL 946
KD DWV + E D+++ CLEERD++ G+ ++ ++ SI +S+K +FV+
Sbjct: 763 AYKDK---DWVWEH--FSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVI 817
Query: 947 TKKYAKSWNFKT-AFYLALQRLMDENMDVIIFILLE--PVLQHSQYLRLRQRICKS-SIL 1002
T K K + A+Q+ +++N+D II + LE P + + L LR+ + KS IL
Sbjct: 818 THHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCIL 877
Query: 1003 QWPDNPKAEGLFWQTLRNVVLTEN 1026
WP + G F L+ + ++N
Sbjct: 878 NWPVQKERIGAFRHKLQVALGSKN 901
Score = 120 bits (302), Expect = 5e-27
Identities = 184/715 (25%), Positives = 300/715 (41%), Gaps = 100/715 (13%)
Query: 46 IAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNG 105
+A+CS+ +L +VP + +T L+L+ N + + +F LT +++ N +
Sbjct: 34 VADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISK---- 89
Query: 106 NPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPS---GLPESLTELSLIQNNIYNIT 162
+ L L+ L L+ N+L Q+ +LTEL L+ N+I I
Sbjct: 90 ----------LEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIK 139
Query: 163 KEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPK--- 219
+ NL L L+ N ++ + G L NL+ L LS N + + +
Sbjct: 140 NNPFVKQKNLITLDLSHN-------GLSSTKLGTQVQLENLQELLLSNNKIQALKSEELD 192
Query: 220 --LPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASIN 277
SSL+KL LS+ QIK S F + L L L+ G S+
Sbjct: 193 IFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNN--------------VQLGPSLT 238
Query: 278 IDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNM--PHLKVLDLEFNYLVGEIASGAFLTM 335
T +R L+LS++ L + F + +L +LDL +N L +
Sbjct: 239 EKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNL--NVVGNDSFAW 296
Query: 336 LPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHL-RGYVFQEL------REDDFQ 388
LP+LE L +N I QH+ S + L ++R L+L R + Q + + DDF
Sbjct: 297 LPQLEYFFLEYNNI-----QHL-FSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFS 350
Query: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSEN--RISPLVKDTRQSYANSSS 446
L L +N+ N I I +F NL+ + LS + + L +T S A+S
Sbjct: 351 -FQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPL 409
Query: 447 FQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSI-FFIGPNQFENLP 505
++ K + + E D S H + LDL LN I + ++ L
Sbjct: 410 HILNLTKNKISKIESDAFSWLGHL-------------EVLDLGLNEIGQELTGQEWRGLE 456
Query: 506 DIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL-DFDNA-SALTELSDLEVLDLSY 563
+I + LS N Q L+ F+ +P ++ L L L + D++ S L +L +LDLS
Sbjct: 457 NIFEIYLSYNKYLQ-LTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN 515
Query: 564 NSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLES-----KSLVELVFSGN 618
N+ IA + + ++ L++L+L HNN+ L N K L L +
Sbjct: 516 NN----IANIND--DMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHL----H 565
Query: 619 RLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKF 678
L++ N D + +FK L L +DL LN L +P F N SL L++ N++
Sbjct: 566 ILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVF-NNQVSLKSLNLQKNLITS 624
Query: 679 FNWTLL-QQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFL 732
+ F L LD+R N +S++ F + + +H I L S +L
Sbjct: 625 VEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINE---THTNIPELSSHYL 676
Score = 34.7 bits (78), Expect = 0.48
Identities = 22/69 (31%), Positives = 35/69 (50%), Gaps = 5/69 (7%)
Query: 701 LFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKT 760
L LT D +++ L L+HN++ LP+ + S L LD+ N + S LE +
Sbjct: 40 LKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTI-----SKLEPEL 94
Query: 761 TTKLSMLEL 769
KL ML++
Sbjct: 95 CQKLPMLKV 103
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 179 bits (455), Expect = 9e-45
Identities = 229/868 (26%), Positives = 367/868 (42%), Gaps = 107/868 (12%)
Query: 210 FNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVP 269
F +L+ VP L ++ +L LS I+ ++ F L L LL+L
Sbjct: 35 FCNLTQVPQVL-NTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQY------------ 81
Query: 270 CDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIAS 329
+ ID+ AF+NL LR L+L S+ + ++ F+ + HL L L F L +
Sbjct: 82 ----TPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLK 137
Query: 330 GAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQP 389
+ L L LDLS N I+ Y + +F KL SL+++ + E + +P
Sbjct: 138 DGYFRNLKALTRLDLSKNQIRSLY-----LHPSFGKLNSLKSIDFSSNQIFLVCEHELEP 192
Query: 390 LMQLPNLSTINLGINFI---KQIDF-KLFQNFSN--LEIIYLSENRISPLVKDT-----R 438
L Q LS +L N + +D+ K F N LEI+ +S N + +
Sbjct: 193 L-QGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAIS 251
Query: 439 QSYANSSSFQRHIRKRRSTDFEF----DPHSN-FYHFTRPLIKPQCAAYG---------- 483
+S A S HI F F DP N F R ++ ++G
Sbjct: 252 KSQAFSLILAHHI---MGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVF 308
Query: 484 ------KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDL 537
K L+L+ N I I F L ++ LNLS N ++ S + F +P V Y+DL
Sbjct: 309 ETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYS-SNFYGLPKVAYIDL 367
Query: 538 TNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIY 597
N + L L+ LDL N+ L I ++ + LS N +
Sbjct: 368 QKNHIAIIQDQTFKFLEKLQTLDLRDNA-----------LTTIHFIPSIPDIFLSGNKLV 416
Query: 598 TLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNE 657
TL K NL + +L+ L S NRL+ L D Y + + +L L L+ NR +
Sbjct: 417 TL-PKINL-TANLIHL--SENRLENL----DILYFLL--RVPHLQILILNQNRFSSCSGD 466
Query: 658 AFLNLPASLTELHINDNMLKF-----FNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTS 712
+ SL +L + +NML+ W + + L++L L N L L + +
Sbjct: 467 QTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLT 526
Query: 713 SLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 772
+LR L L+ NR++ L L ++L+ LD+S N L N LS+L++ N
Sbjct: 527 ALRGLSLNSNRLTVLSHNDLP--ANLEILDISRNQLLAPNPDVF-----VSLSVLDITHN 579
Query: 773 PFECTCDIGDFRRWMDEHLNVKIP-RLVDVICASPGDQRGKSIVSLELTTCVSDVTAVIL 831
F C C++ F W++ H NV I D+ C P G S+ SL C + L
Sbjct: 580 KFICECELSTFINWLN-HTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSL 638
Query: 832 FFFTFFI----TTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLSTSQTF--YDAYIS 885
F F + T+ ++ L F + Y V T YDAY+
Sbjct: 639 KFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLC 698
Query: 886 YDTKDASVTDWVINELRYHLE-ESRDKNVL-LCLEERDWDPGLAIIDNLMQSINQSKKTV 943
+ +KD + WV N L HL+ + D+N LC EERD+ PG I N+ +I S+K V
Sbjct: 699 FSSKDFT---WVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIV 755
Query: 944 FVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQHS--QYLRLRQRICKSSI 1001
++++ + + AF A R + + +I +++ + Q+ ++ +R + K
Sbjct: 756 CLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQY 815
Query: 1002 LQWPDNPKAEGLFWQTLRNVVLTENDSR 1029
L+WP++ + G F L +L + +
Sbjct: 816 LRWPEDLQDVGWFLHKLSQQILKKEKEK 843
Score = 49.3 bits (116), Expect = 2e-05
Identities = 70/244 (28%), Positives = 114/244 (46%), Gaps = 57/244 (23%)
Query: 68 LDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGN---------PGIQSNGLN-IT 117
L+L+ N I I +E+F GL NL +NL++N + + N +Q N + I
Sbjct: 317 LNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQ 376
Query: 118 DGAFLNLKNLRELLLEDNQL------PQIP----SG-----LPE-SLTE--LSLIQNNIY 159
D F L+ L+ L L DN L P IP SG LP+ +LT + L +N +
Sbjct: 377 DQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLE 436
Query: 160 NI-TKEGISRLINLKNLYLAWNCYFNKVCEKTNIED-----------------------G 195
N+ + R+ +L+ L L N + + ++T E+
Sbjct: 437 NLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWD 496
Query: 196 VFETLTNLELLSLSFNSLSHVPPKLPS---SLRKLFLSNTQIKYISEEDFKGLINLTLLD 252
VFE L++L++L L+ N L+ +PP + S +LR L L++ ++ +S D NL +LD
Sbjct: 497 VFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPA--NLEILD 554
Query: 253 LSGN 256
+S N
Sbjct: 555 ISRN 558
Score = 48.1 bits (113), Expect = 4e-05
Identities = 78/371 (21%), Positives = 134/371 (36%), Gaps = 61/371 (16%)
Query: 461 FDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQV 520
FD FY F PQ + L LS N I + + F L + L L +
Sbjct: 26 FDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLT 85
Query: 521 LSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSY--------NSHYFRIAG 572
+ F +P+++ LDL ++++ F + A L L L L + YFR
Sbjct: 86 IDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLK 145
Query: 573 VTHHLEFIQN-------------FTNLKVLNLSHNNIYTLTDK--YNLESKSLVELVFSG 617
L+ +N +LK ++ S N I+ + + L+ K+L +
Sbjct: 146 ALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAA 205
Query: 618 N----RLDILW----NDDDNRYISIFKGLKNLTRLDLSLN-------------------- 649
N R+ + W N N + I N +D++ N
Sbjct: 206 NSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIM 265
Query: 650 -------RLKHIPNEAFLNLP-ASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLL 701
+K F L +S+ L ++ + N + + L++L+L NK+
Sbjct: 266 GAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKIN 325
Query: 702 FLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTT 761
+ D +L+ L LS+N + L S + + ++DL N + I K
Sbjct: 326 KIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTF--KFL 383
Query: 762 TKLSMLELHGN 772
KL L+L N
Sbjct: 384 EKLQTLDLRDN 394
Score = 45.1 bits (105), Expect = 4e-04
Identities = 87/329 (26%), Positives = 130/329 (39%), Gaps = 92/329 (27%)
Query: 65 VTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNL 124
V LDLS F+ + + F+ L++L +NL +N + N I D AF L
Sbjct: 290 VRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYN------------KIN--KIADEAFYGL 335
Query: 125 KNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFN 184
NL+ L L N L + L +N Y + K I+L+ ++A
Sbjct: 336 DNLQVLNLSYNLLGE-------------LYSSNFYGLPKVA---YIDLQKNHIA------ 373
Query: 185 KVCEKTNIEDGVFETLTNLELLSLSFNSLS--HVPPKLPSSLRKLFLSNTQIKYISEEDF 242
I+D F+ L L+ L L N+L+ H P +P +FLS ++ + +
Sbjct: 374 ------IIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPD----IFLSGNKLVTLPK--- 420
Query: 243 KGLINLT--LLDLSGNCPRCFNAPFPC--VPCDGGASINIDRFAFQNLTQLRYLNLSSTS 298
INLT L+ LS N + + VP +N +RF+ + Q N S
Sbjct: 421 ---INLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQ 477
Query: 299 L----RKINAAW--------FKNMPHLKVLDLEFNYLVGEIASGAF-------------- 332
L + AW F+ + HL+VL L NYL + G F
Sbjct: 478 LFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYL-NSLPPGVFSHLTALRGLSLNSN 536
Query: 333 -LTML------PRLEILDLSFNYIKGSYP 354
LT+L LEILD+S N + P
Sbjct: 537 RLTVLSHNDLPANLEILDISRNQLLAPNP 565
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 167 bits (424), Expect = 4e-41
Identities = 217/839 (25%), Positives = 338/839 (40%), Gaps = 120/839 (14%)
Query: 209 SFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCV 268
S SL+ +P L +++ L LSN +I YIS D + RC N
Sbjct: 39 SSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQ---------------RCVN------ 77
Query: 269 PCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIA 328
L+ L L+S + I F ++ L+ LDL +NYL
Sbjct: 78 --------------------LQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSN--L 115
Query: 329 SGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGY-VFQELREDDF 387
S ++ L L L+L N K + + FS L L+ L + F +++ DF
Sbjct: 116 SSSWFKPLSSLTFLNLLGNPYKT-----LGETSLFSHLTKLQILRVGNMDTFTKIQRKDF 170
Query: 388 QPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSF 447
L L L + + K QN S+L + + + D S
Sbjct: 171 AGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSV------ 224
Query: 448 QRHIRKRRSTDFEFDPHSNFYHF-------TRPLIKPQCAAYGKALDLSLNSIFFIGPNQ 500
+ R TD + +HF T LIK K D SL + + NQ
Sbjct: 225 --ECLELRDTDLDT------FHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKL-LNQ 275
Query: 501 FENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLD------FDNASALTELS 554
L ++ + + N + I K LT RL F + S L L+
Sbjct: 276 ISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLT 335
Query: 555 DLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESK------ 608
+ NS F + + Q+ +L+ L+LS N + ++Y S
Sbjct: 336 ERVKRITVENSKVFLVPCLLS-----QHLKSLEYLDLSEN---LMVEEYLKNSACEDAWP 387
Query: 609 SLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTE 668
SL L+ N L L + LKNLT +D+S N +P P +
Sbjct: 388 SLQTLILRQNHLASLEKTGETLLT-----LKNLTNIDISKNSFHSMPETC--QWPEKMKY 440
Query: 669 LHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLP 728
L+++ + + + LE+LD+ N L + +L L+ L +S N++ LP
Sbjct: 441 LNLSSTRIHSVTGCIPKT---LEILDVSNNNLNLFSLNLPQ----LKELYISRNKLMTLP 493
Query: 729 SGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMD 788
L + L L +S N + T +K L++ T K LE GN F C+C+ F +
Sbjct: 494 DASL--LPMLLVLKISRNAITTFSKEQLDSFHTLKT--LEAGGNNFICSCEFLSFTQEQQ 549
Query: 789 EHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALA 848
V I + +C SP RG+ + + L+ TA++ +++ L
Sbjct: 550 ALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLC 609
Query: 849 HHLF-YWDVWFIYNVCLAKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEE 907
H W + ++ AK K R + YDA++SY +DA WV N + LE
Sbjct: 610 HRFHGLWYMKMMWAWLQAKRKP-RKAPSRNICYDAFVSYSERDAY---WVENLMVQELEN 665
Query: 908 SRDKNVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRL 967
LCL +RD+ PG IIDN++ SI +S KTVFVL++ + KS K + RL
Sbjct: 666 FNPP-FKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRL 724
Query: 968 MDENMDVIIFILLEPVLQHS---QYLRLRQRICKSSILQWP-DNPKAEGLFWQTLRNVV 1022
DEN D I ILLEP+ + + ++ +LR+ + + L+WP D + EG FW LR +
Sbjct: 725 FDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREG-FWVNLRAAI 782
Score = 50.8 bits (120), Expect = 6e-06
Identities = 143/614 (23%), Positives = 234/614 (38%), Gaps = 114/614 (18%)
Query: 10 MLTCIFLLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELD 69
M+ + ++IS S E E + S CD I + S+ L +P + + V LD
Sbjct: 7 MVWVLGVIISLSKE---ESSNQASLSCDRNG-----ICKGSSGSLNSIPSGLTEAVKSLD 58
Query: 70 LSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLN-ITDGAFLNLKNLR 128
LS+N IT+I+N Q NL + L SNG+N I + +F +L +L
Sbjct: 59 LSNNRITYISNSDLQRCVNLQALVLT---------------SNGINTIEEDSFSSLGSLE 103
Query: 129 ELLLEDNQLPQIPSGL---PESLTELSLIQNNIYNITKEGI-SRLINLKNLYLAWNCYFN 184
L L N L + S SLT L+L+ N + + + S L L+ L + F
Sbjct: 104 HLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFT 163
Query: 185 KVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKG 244
K+ K F LT LE L + + L PK S++ + +K
Sbjct: 164 KIQRKD------FAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQ-------- 209
Query: 245 LINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINA 304
++ LL++ F V C ++D F F L+ +++ ++K
Sbjct: 210 --HILLLEI-------FVDVTSSVECLELRDTDLDTFHFSELS----TGETNSLIKKFT- 255
Query: 305 AWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHIN---ISR 361
F+N+ + L+ +I+ L LE D + N + G++ N I
Sbjct: 256 --FRNVKITDESLFQVMKLLNQISG------LLELEFDDCTLNGV-GNFRASDNDRVIDP 306
Query: 362 NFSKLLSLRALHL-RGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL 420
+ L++R LH+ R Y+F +L L + T+ F+ + L Q+ +L
Sbjct: 307 GKVETLTIRRLHIPRFYLFYDL--STLYSLTERVKRITVENSKVFL--VPCLLSQHLKSL 362
Query: 421 EIIYLSENRI------SPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPL 474
E + LSEN + + +D S Q H+ T N +
Sbjct: 363 EYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTN----- 417
Query: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPH-VK 533
+D+S NS F P + + LNLS+ V IP ++
Sbjct: 418 -----------IDISKNS-FHSMPETCQWPEKMKYLNLSSTRIHSVT-----GCIPKTLE 460
Query: 534 YLDLTNNRLD------------FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQ 581
LD++NN L+ + + + L L D +L + R A T E +
Sbjct: 461 ILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLD 520
Query: 582 NFTNLKVLNLSHNN 595
+F LK L NN
Sbjct: 521 SFHTLKTLEAGGNN 534
Score = 34.3 bits (77), Expect = 0.63
Identities = 36/132 (27%), Positives = 57/132 (43%), Gaps = 14/132 (10%)
Query: 63 KYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNP------GIQSNGLNI 116
K +T +D+S N H E+ Q + + +NL+ P + +N LN+
Sbjct: 413 KNLTNIDISKNSF-HSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNL 471
Query: 117 TDGAFLNLKNLRELLLEDNQLPQIP-SGLPESLTELSLIQNNIYNITKEGISRLINLKNL 175
LNL L+EL + N+L +P + L L L + +N I +KE + LK L
Sbjct: 472 FS---LNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTL 528
Query: 176 YLAWNCYFNKVC 187
N N +C
Sbjct: 529 EAGGN---NFIC 537
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 166 bits (420), Expect = 1e-40
Identities = 220/871 (25%), Positives = 381/871 (43%), Gaps = 108/871 (12%)
Query: 187 CEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLI 246
C + + E + N+ + N +P LP S + L LS ++++ F
Sbjct: 20 CVRPESWEPCVEVVPNITYQCMELNFYK-IPDNLPFSTKNLDLSFNPLRHLGSYSFFSFP 78
Query: 247 NLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAW 306
L +LDLS RC I+ A+Q+L+ L L L+ ++ +
Sbjct: 79 ELQVLDLS----RC-------------EIQTIEDGAYQSLSHLSTLILTGNPIQSLALGA 121
Query: 307 FKNMPHL-KVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSK 365
F + L K++ +E N E + L L+ L+++ N I Q + FS
Sbjct: 122 FSGLSSLQKLVAVETNLASLENFP---IGHLKTLKELNVAHNLI-----QSFKLPEYFSN 173
Query: 366 LLSLRALHLRGYVFQELREDDFQPLMQLPNLS-TINLGINFIKQIDFKLFQNFSNLEIIY 424
L +L L L Q + D + L Q+P L+ +++L +N + I F+ ++
Sbjct: 174 LTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIRLHKLTL 233
Query: 425 LSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQC----- 479
+ ++K Q A + R EF N F + ++ C
Sbjct: 234 RNNFDSLNVMKTCIQGLAG-------LEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIE 286
Query: 480 ---AAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQV-------------LSG 523
AY LD L+ I + F L +++ +L + + +V L
Sbjct: 287 EFRLAY---LDYYLDDIIDL----FNCLTNVSSFSLVSVTIERVKDFSYNFGWQHLELVN 339
Query: 524 TEFSAIPHVKYLDLTNNRLDFD-----NASALTELSDLEVLDLSYNSHYFRIAGVTHHLE 578
+F P +K L RL F NA + +L LE LDLS N F+ G +
Sbjct: 340 CKFGQFPTLKLKSL--KRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFK--GCCSQSD 395
Query: 579 FIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGL 638
F T+LK L+LS N + T++ + L + L L F + L + S+F L
Sbjct: 396 F--GTTSLKYLDLSFNGVITMSSNF-LGLEQLEHLDFQHSNLKQMSE------FSVFLSL 446
Query: 639 KNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKF-FNWTLLQQFPRLELLDLRG 697
+NL LD+S + N F L +SL L + N + F + + L LDL
Sbjct: 447 RNLIYLDISHTHTRVAFNGIFNGL-SSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQ 505
Query: 698 NKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALE 757
+L L+ + + SSL+ L +SHN L + ++SL+ LD S N + T K L+
Sbjct: 506 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDYSLNHIMTSKKQELQ 565
Query: 758 TKTTTKLSMLELHGNPFECTCDIGDFRRWMDE--HLNVKIPRLVDVICASPGDQRGKSIV 815
+ L+ L L N F CTC+ F +W+ + L V++ R+ CA+P D++G ++
Sbjct: 566 -HFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVEVERME---CATPSDKQGMPVL 621
Query: 816 SLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDVWFIYNVCLAKVKGYRSLST 875
SL + TC + T + + + + ++V A+ + FY+ + + C+ +G
Sbjct: 622 SLNI-TCQMNKTIIGVSVLSVLVVSVV---AVLVYKFYFHLMLLAG-CIKYGRG------ 670
Query: 876 SQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLLCLEERDWDPGLAIIDNLM-Q 934
+ YDA++ Y ++D DWV NEL +LEE LCL RD+ PG+AI N++ +
Sbjct: 671 -ENIYDAFVIYSSQD---EDWVRNELVKNLEEGVPP-FQLCLHYRDFIPGVAIAANIIHE 725
Query: 935 SINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVIIFILLEPVLQH--SQYLRL 992
++S+K + V+++ + +S + +A + IIFI+L+ V + Q + L
Sbjct: 726 GFHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKVEKTLLRQQVEL 785
Query: 993 RQRICKSSILQWPDNPKAEGLFWQTLRNVVL 1023
+ + +++ L+W D+ +FW+ LR +L
Sbjct: 786 YRLLSRNTYLEWEDSVLGRHIFWRRLRKALL 816
Score = 70.5 bits (171), Expect = 8e-12
Identities = 140/593 (23%), Positives = 248/593 (41%), Gaps = 91/593 (15%)
Query: 35 PCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINL 94
PC E N + +C ++P + LDLS N + H+ + SF L ++L
Sbjct: 28 PCVEVVPN--ITYQCMELNFYKIPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDL 85
Query: 95 NHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIP----SGLPESLTE 150
+ IQ+ I DGA+ +L +L L+L N + + SGL SL +
Sbjct: 86 SRCE----------IQT----IEDGAYQSLSHLSTLILTGNPIQSLALGAFSGL-SSLQK 130
Query: 151 LSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSF 210
L ++ N+ ++ I L LK L +A N + + + + F LTNLE L LS
Sbjct: 131 LVAVETNLASLENFPIGHLKTLKELNVAHN-----LIQSFKLPE-YFSNLTNLEHLDLSS 184
Query: 211 NSLS-------HVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNA 263
N + V ++P L LS + +I FK I L L L N N
Sbjct: 185 NKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKE-IRLHKLTLRNNFDS-LNV 242
Query: 264 PFPCVPCDGGASINIDRFA---FQNLTQLRYLNLSSTS-LRKINAAWFKNMPHLK----- 314
C+ G A + + R F+N L + S+ L + F+ + +L
Sbjct: 243 MKTCI--QGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTIEEFR-LAYLDYYLDD 299
Query: 315 VLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHIN-ISRNFSKLLSLRALH 373
++DL FN L + + R++ +F + QH+ ++ F + +L+
Sbjct: 300 IIDL-FNCLTNVSSFSLVSVTIERVKDFSYNFGW------QHLELVNCKFGQFPTLKLKS 352
Query: 374 LRGYVFQELREDDFQPLMQLPNLSTINL---GINF---IKQIDFKLFQNFSNLEIIYLSE 427
L+ F + + + LP+L ++L G++F Q DF ++L+ + LS
Sbjct: 353 LKRLTFTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSDF----GTTSLKYLDLSF 408
Query: 428 NRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTR--PLIKPQCAAYGKA 485
N + + SS+F + + DF+ HSN + + + Y
Sbjct: 409 NGVITM----------SSNFLG-LEQLEHLDFQ---HSNLKQMSEFSVFLSLRNLIY--- 451
Query: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 545
LD+S F L + L ++ NS + F+ + ++ +LDL+ +L+
Sbjct: 452 LDISHTHTRVAFNGIFNGLSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQCQLEQL 511
Query: 546 NASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYT 598
+ +A LS L+VL++S+N ++F + + + +L+VL+ S N+I T
Sbjct: 512 SPTAFNSLSSLQVLNMSHN-NFFSLDTFPY-----KCLNSLQVLDYSLNHIMT 558
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 159 bits (401), Expect = 2e-38
Identities = 210/840 (25%), Positives = 367/840 (43%), Gaps = 104/840 (12%)
Query: 205 LLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAP 264
L+ S N L HVP L L +S I + D L L +L +S N +
Sbjct: 28 LVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSDILSLSKLRILIISHNRIQY---- 83
Query: 265 FPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLV 324
++I F F +L YL+LS L KI+ N+ HL DL FN
Sbjct: 84 -----------LDISVFKFNQ--ELEYLDLSHNKLVKISCHPTVNLKHL---DLSFNAFD 127
Query: 325 GEIASGAFLTMLPRLEILDLSFNYIKGSYP---QHINISRNFSKLLSLRALHLRGYVFQE 381
F M +L+ L LS +++ S H+NIS+ L + G + E
Sbjct: 128 ALPICKEFGNM-SQLKFLGLSTTHLEKSSVLPIAHLNISK---------VLLVLGETYGE 177
Query: 382 LREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSY 441
+ + L + +T +L I F +F + S + L + I +++D + SY
Sbjct: 178 KEDPE-----GLQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSY 232
Query: 442 ANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQF 501
S + + S + + + F R L Q + S++++ G F
Sbjct: 233 FLSILAKLQTNPKLSNLTLNNIETTWNSFIRIL---QLVWHTTVWYFSISNVKLQGQLDF 289
Query: 502 ENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDL 561
+ D + +L A S QV+S + P ++ +N ++ N + ++ + +L
Sbjct: 290 RDF-DYSGTSLKALSIHQVVS--DVFGFPQSYIYEIFSN-MNIKNFT-VSGTRMVHMLCP 344
Query: 562 SYNSHYFRIAGVTHHLEFIQNF-TNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRL 620
S S + HL+F N T+ N H LT+ L L+ N+L
Sbjct: 345 SKISPFL-------HLDFSNNLLTDTVFENCGH-----LTE--------LETLILQMNQL 384
Query: 621 DILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFN 680
L ++ + +K+L +LD+S N + + + + SL L+++ N+L
Sbjct: 385 KEL-----SKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKSLLSLNMSSNILTDTI 439
Query: 681 WTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKH 740
+ L PR+++LDL NK+ + + +L+ L ++ N ++ LP SSL
Sbjct: 440 FRCLP--PRIKVLDLHSNKIKSIPKQVVKL-EALQELNVAFNSLTDLPG--CGSFSSLSV 494
Query: 741 LDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVD 800
L + N + + SA ++ K+ ++ NPF+CTC++G+F + +D+ + + D
Sbjct: 495 LIIDHNSVS--HPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSSEVLEGWPD 552
Query: 801 VI-CASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDV-WF 858
C P RG + ++ ++T +I+ T T +V+ + Y D+ W+
Sbjct: 553 SYKCDYPESYRGTLLKDFHMSELSCNITLLIV---TIVATMLVLAVTVTSLCSYLDLPWY 609
Query: 859 IYNVCL-------AKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDK 911
+ VC A+ L + F+ A+ISY D+ WV NEL +LE+ +
Sbjct: 610 LRMVCQWTQTRRRARNIPLEELQRNLQFH-AFISYSGHDSF---WVKNELLPNLEK---E 662
Query: 912 NVLLCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDEN 971
+ +CL ER++ PG +I++N++ I +S K++FVL+ + +S Y A L E
Sbjct: 663 GMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEG 722
Query: 972 MDVIIFILLEPVLQH---SQYLRLRQRICKSSILQWPDNPKAEGLFWQTLR---NVVLTE 1025
+ +I ILLEP+ Q+ S Y +L+ + + + L+WP GLFW LR N+ LTE
Sbjct: 723 SNSLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLTE 782
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 146 bits (369), Expect = 9e-35
Identities = 186/770 (24%), Positives = 332/770 (43%), Gaps = 92/770 (11%)
Query: 283 FQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEIL 342
F ++++LR L L +++++ F+ L+ LDL N L +L L L
Sbjct: 68 FHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRL-----KSVTWYLLAGLRYL 122
Query: 343 DLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLG 402
DLSFN + I + L L L G ++++ DFQ + L +L+T+ LG
Sbjct: 123 DLSFNDF-----DTMPICEEAGNMSHLEILGLSG---AKIQKSDFQKIAHL-HLNTVFLG 173
Query: 403 INFIKQIDFKLFQ--NFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF- 459
+ + N + L I+ + L++D I+ + +
Sbjct: 174 FRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDG-------------IKTSKILEMT 220
Query: 460 EFDPHSNF--YHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 517
D S F Y R L K L LN + + + F L + ++
Sbjct: 221 NIDGKSQFVSYEMQRNLSLENA----KTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQI 276
Query: 518 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALT---ELSDLEVLDLSYNSHYFRIAGVT 574
V G + YLD +N D+ N T E V + + Y + +
Sbjct: 277 RNVTFGGK-------AYLD--HNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMD 327
Query: 575 -----------HHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDIL 623
H+ F T + LN ++N + K ++ L L+ +GN+L+ L
Sbjct: 328 IENLTISNAQMPHMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETL 387
Query: 624 WNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTL 683
+S F L LDLS N L+H N+ + P ++ ++++ N L +
Sbjct: 388 ------SLVSCFANNTPLEHLDLSQNLLQH-KNDENCSWPETVVNMNLSYNKLSDSVFRC 440
Query: 684 LQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDL 743
L + +++LDL N++ + + LR L ++ N ++ LP S S L L++
Sbjct: 441 LPK--SIQILDLNNNQIQTVPKETIHLMA-LRELNIAFNFLTDLPG--CSHFSRLSVLNI 495
Query: 744 SSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVD-VI 802
N + ++ S ++ ++ L NPF CTC++ +F + ++ + V + D
Sbjct: 496 EMNFI--LSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQ-LETYSEVMMVGWSDSYT 552
Query: 803 CASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDV-WFIYN 861
C P + RG + + L + +I+ T + +V+ A+A ++D+ W++
Sbjct: 553 CEYPLNLRGTRLKDVHLHELSCNTALLIV---TIVVIMLVLGLAVAFCCLHFDLPWYLRM 609
Query: 862 VCLAKVKGYRSLSTSQ------TFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLL 915
+ +R T+Q + A+ISY D+ WV NEL +LE+ D ++L+
Sbjct: 610 LGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSL---WVKNELIPNLEKE-DGSILI 665
Query: 916 CLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVI 975
CL E +DPG +I +N++ I +S K++FVL+ + ++ FY A L EN D I
Sbjct: 666 CLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHI 725
Query: 976 IFILLEPVLQH---SQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVV 1022
I ILLEP+ + ++Y +L+ + K + L+WP + + GLFW LR +
Sbjct: 726 ILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAI 775
Score = 42.0 bits (97), Expect = 0.003
Identities = 32/88 (36%), Positives = 40/88 (45%), Gaps = 5/88 (5%)
Query: 688 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 747
P LDL N L L S S LR L+L HNRI L L++LDLS+N
Sbjct: 48 PATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNR 107
Query: 748 LKTINKSALETKTTTKLSMLELHGNPFE 775
LK++ L L L+L N F+
Sbjct: 108 LKSVTWYLL-----AGLRYLDLSFNDFD 130
Score = 41.2 bits (95), Expect = 0.005
Identities = 48/174 (27%), Positives = 76/174 (43%), Gaps = 18/174 (10%)
Query: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 545
LDLS N +F + + F ++ + L L N Q L F ++YLDL+NNRL
Sbjct: 53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHN-RIQQLDLKTFEFNKELRYLDLSNNRL--- 108
Query: 546 NASALTELSDLEVLDLSYNSH----YFRIAGVTHHLEF-------IQNFTNLKVLNLSHN 594
+ L+ L LDLS+N AG HLE IQ K+ +L N
Sbjct: 109 KSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLN 168
Query: 595 NIYT-LTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLS 647
++ + E SL + + +L I+ D N ++ + G+K L+++
Sbjct: 169 TVFLGFRTLPHYEEGSLP--ILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMT 220
Score = 36.6 bits (83), Expect = 0.13
Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 14/120 (11%)
Query: 38 EKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHN 97
E + ++ CSN L++VP + T LDLS N + + + F + L + L HN
Sbjct: 23 ELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHN 82
Query: 98 PNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNN 157
IQ L F K LR L L +N+L + L L L L N+
Sbjct: 83 ----------RIQQLDLK----TFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFND 128
Score = 31.2 bits (69), Expect = 5.3
Identities = 34/98 (34%), Positives = 43/98 (43%), Gaps = 18/98 (18%)
Query: 559 LDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGN 618
LDLSYN F++ H + + L+VL L HN I L K +K L L S N
Sbjct: 53 LDLSYNL-LFQLQSSDFH-----SVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNN 106
Query: 619 RL-DILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIP 655
RL + W Y+ L L LDLS N +P
Sbjct: 107 RLKSVTW------YL-----LAGLRYLDLSFNDFDTMP 133
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 146 bits (369), Expect = 9e-35
Identities = 186/770 (24%), Positives = 332/770 (43%), Gaps = 92/770 (11%)
Query: 283 FQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEIL 342
F ++++LR L L +++++ F+ L+ LDL N L +L L L
Sbjct: 68 FHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRL-----KSVTWYLLAGLRYL 122
Query: 343 DLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLG 402
DLSFN + I + L L L G ++++ DFQ + L +L+T+ LG
Sbjct: 123 DLSFNDF-----DTMPICEEAGNMSHLEILGLSG---AKIQKSDFQKIAHL-HLNTVFLG 173
Query: 403 INFIKQIDFKLFQ--NFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF- 459
+ + N + L I+ + L++D I+ + +
Sbjct: 174 FRTLPHYEEGSLPILNTTKLHIVLPMDTNFWVLLRDG-------------IKTSKILEMT 220
Query: 460 EFDPHSNF--YHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSN 517
D S F Y R L K L LN + + + F L + ++
Sbjct: 221 NIDGKSQFVSYEMQRNLSLENA----KTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQI 276
Query: 518 AQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALT---ELSDLEVLDLSYNSHYFRIAGVT 574
V G + YLD +N D+ N T E V + + Y + +
Sbjct: 277 RNVTFGGK-------AYLD--HNSFDYSNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMD 327
Query: 575 -----------HHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDIL 623
H+ F T + LN ++N + K ++ L L+ +GN+L+ L
Sbjct: 328 IENLTISNAQMPHMLFPNYPTKFQYLNFANNILTDELFKRTIQLPHLKTLILNGNKLETL 387
Query: 624 WNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTL 683
+S F L LDLS N L+H N+ + P ++ ++++ N L +
Sbjct: 388 ------SLVSCFANNTPLEHLDLSQNLLQH-KNDENCSWPETVVNMNLSYNKLSDSVFRC 440
Query: 684 LQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDL 743
L + +++LDL N++ + + LR L ++ N ++ LP S S L L++
Sbjct: 441 LPK--SIQILDLNNNQIQTVPKETIHLMA-LRELNIAFNFLTDLPG--CSHFSRLSVLNI 495
Query: 744 SSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVD-VI 802
N + ++ S ++ ++ L NPF CTC++ +F + ++ + V + D
Sbjct: 496 EMNFI--LSPSLDFVQSCQEVKTLNAGRNPFRCTCELKNFIQ-LETYSEVMMVGWSDSYT 552
Query: 803 CASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDV-WFIYN 861
C P + RG + + L + +I+ T + +V+ A+A ++D+ W++
Sbjct: 553 CEYPLNLRGTRLKDVHLHELSCNTALLIV---TIVVIMLVLGLAVAFCCLHFDLPWYLRM 609
Query: 862 VCLAKVKGYRSLSTSQ------TFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVLL 915
+ +R T+Q + A+ISY D+ WV NEL +LE+ D ++L+
Sbjct: 610 LGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSL---WVKNELIPNLEKE-DGSILI 665
Query: 916 CLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDVI 975
CL E +DPG +I +N++ I +S K++FVL+ + ++ FY A L EN D I
Sbjct: 666 CLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFYFAHHNLFHENSDHI 725
Query: 976 IFILLEPVLQH---SQYLRLRQRICKSSILQWPDNPKAEGLFWQTLRNVV 1022
I ILLEP+ + ++Y +L+ + K + L+WP + + GLFW LR +
Sbjct: 726 ILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANLRAAI 775
Score = 42.0 bits (97), Expect = 0.003
Identities = 32/88 (36%), Positives = 40/88 (45%), Gaps = 5/88 (5%)
Query: 688 PRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL 747
P LDL N L L S S LR L+L HNRI L L++LDLS+N
Sbjct: 48 PATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNR 107
Query: 748 LKTINKSALETKTTTKLSMLELHGNPFE 775
LK++ L L L+L N F+
Sbjct: 108 LKSVTWYLL-----AGLRYLDLSFNDFD 130
Score = 41.2 bits (95), Expect = 0.005
Identities = 48/174 (27%), Positives = 76/174 (43%), Gaps = 18/174 (10%)
Query: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 545
LDLS N +F + + F ++ + L L N Q L F ++YLDL+NNRL
Sbjct: 53 LDLSYNLLFQLQSSDFHSVSKLRVLILCHN-RIQQLDLKTFEFNKELRYLDLSNNRL--- 108
Query: 546 NASALTELSDLEVLDLSYNSH----YFRIAGVTHHLEF-------IQNFTNLKVLNLSHN 594
+ L+ L LDLS+N AG HLE IQ K+ +L N
Sbjct: 109 KSVTWYLLAGLRYLDLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLN 168
Query: 595 NIYT-LTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLS 647
++ + E SL + + +L I+ D N ++ + G+K L+++
Sbjct: 169 TVFLGFRTLPHYEEGSLP--ILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMT 220
Score = 36.6 bits (83), Expect = 0.13
Identities = 34/120 (28%), Positives = 49/120 (40%), Gaps = 14/120 (11%)
Query: 38 EKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHN 97
E + ++ CSN L++VP + T LDLS N + + + F + L + L HN
Sbjct: 23 ELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQLQSSDFHSVSKLRVLILCHN 82
Query: 98 PNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNN 157
IQ L F K LR L L +N+L + L L L L N+
Sbjct: 83 ----------RIQQLDLK----TFEFNKELRYLDLSNNRLKSVTWYLLAGLRYLDLSFND 128
Score = 31.2 bits (69), Expect = 5.3
Identities = 34/98 (34%), Positives = 43/98 (43%), Gaps = 18/98 (18%)
Query: 559 LDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGN 618
LDLSYN F++ H + + L+VL L HN I L K +K L L S N
Sbjct: 53 LDLSYNL-LFQLQSSDFH-----SVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNN 106
Query: 619 RL-DILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIP 655
RL + W Y+ L L LDLS N +P
Sbjct: 107 RLKSVTW------YL-----LAGLRYLDLSFNDFDTMP 133
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 146 bits (368), Expect = 1e-34
Identities = 199/828 (24%), Positives = 348/828 (42%), Gaps = 105/828 (12%)
Query: 209 SFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCV 268
S L HVP LP + L +S I + D L LT+L LS N +
Sbjct: 39 SKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQL-------- 90
Query: 269 PCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIA 328
+D F+ L YL+LS L+KI+ + HL DL FN
Sbjct: 91 ---------LDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHL---DLSFNDFKALPI 138
Query: 329 SGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQ 388
F L +L L LS + Q +++ LS L LR Y +E + Q
Sbjct: 139 CKEFGN-LSQLNFLGLSAMKL-----QKLDLLPIAHLHLSYILLDLRNYYIKENETESLQ 192
Query: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 448
L N T++L + ++ + + L + L+ +++ D Q + S
Sbjct: 193 IL----NAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLND---DNCQVFIKFLS-- 243
Query: 449 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 508
E S +FT I+ + + P ++ N+ ++
Sbjct: 244 -----------ELTRGSTLLNFTLNHIETTWKCLVRVFQF-----LWPKPVEYLNIYNLT 287
Query: 509 CLNLSANSNAQVLSGTEFSA--IPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSH 566
+ S S T A I H+ TN F + T S++ ++ L+ +
Sbjct: 288 IIE-SIREEDFTYSKTTLKALTIEHI-----TNQVFLFSQTALYTVFSEMNIMMLTISDT 341
Query: 567 YFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVEL---VFSGNRLDIL 623
F H+ + K LN + N TD + +LV+L + N L L
Sbjct: 342 PFI------HMLCPHAPSTFKFLNFTQN---VFTDSIFEKCSTLVKLETLILQKNGLKDL 392
Query: 624 WNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTL 683
+ + + K + +L LD+S N L+ ++ S+ L+++ NML +
Sbjct: 393 F-----KVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRC 447
Query: 684 LQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDL 743
L PR+++LDL NK+ + + +L+ L ++ N ++ LP SSL L +
Sbjct: 448 LP--PRIKVLDLHSNKIKSVPKQVVKL-EALQELNVAFNSLTDLPG--CGSFSSLSVLII 502
Query: 744 SSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVI- 802
N + + SA ++ K+ ++ NPF+CTC++ +F + +D+ + + D
Sbjct: 503 DHNSVS--HPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYK 560
Query: 803 CASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDV-WFIYN 861
C P RG + ++ ++T +I+ T T +V+ + Y D+ W++
Sbjct: 561 CDYPESYRGSPLKDFHMSELSCNITLLIV---TIGATMLVLAVTVTSLCIYLDLPWYLRM 617
Query: 862 VCL-------AKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVL 914
VC A+ L + F+ A+ISY D++ WV +EL +LE+ +++
Sbjct: 618 VCQWTQTRRRARNIPLEELQRNLQFH-AFISYSEHDSA---WVKSELVPYLEK---EDIQ 670
Query: 915 LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDV 974
+CL ER++ PG +I++N++ I +S K++FVL+ + +S Y A L E +
Sbjct: 671 ICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNN 730
Query: 975 IIFILLEPVLQHS---QYLRLRQRICKSSILQWPDNPKAEGLFWQTLR 1019
+I ILLEP+ Q+S +Y +L+ + + + LQWP GLFW +R
Sbjct: 731 LILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIR 778
Score = 30.4 bits (67), Expect = 9.1
Identities = 16/48 (33%), Positives = 23/48 (47%)
Query: 50 SNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHN 97
S R L VP+ + LD+S N+I + L LT + L+HN
Sbjct: 39 SKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHN 86
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 130 bits (327), Expect = 6e-30
Identities = 224/914 (24%), Positives = 351/914 (38%), Gaps = 203/914 (22%)
Query: 36 CDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLN 95
C K + +C L+ VP+ + + LDL N IT IT F GL+NL ++L
Sbjct: 34 CPTKCTCSAASVDCHGLGLRAVPRGIPRNAERLDLDRNNITRITKMDFAGLKNLRVLHL- 92
Query: 96 HNPNVQHQNGNPGIQSNGLNITD-GAFLNLKNLRELLLEDNQLPQIPSGLPES---LTEL 151
+ N +++ + GAF +LK L L L N+L +P L +S LT L
Sbjct: 93 --------------EDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRL 138
Query: 152 SLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFN 211
L +N I I ++ + ++KNL L N + IEDG F L +LE+L+L+ N
Sbjct: 139 DLSENQIQGIPRKAFRGITDVKNLQLDNN-------HISCIEDGAFRALRDLEILTLNNN 191
Query: 212 SLS--------HVPPKLPSSLRKLFLSNTQI----------KYISEEDFKGLINLTL--L 251
++S H+P +R L L + + ++ + G L + +
Sbjct: 192 NISRILVTSFNHMP-----KIRTLRLHSNHLYCDCHLAWLSDWLRQRRTVGQFTLCMAPV 246
Query: 252 DLSG-----------NCP-----------RCFNAPFPC------VPCDGGASINIDRFAF 283
L G CP + P PC V C G + I
Sbjct: 247 HLRGFNVADVQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLP 306
Query: 284 QNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILD 343
+ + ++R L S++ I A F LK +D+ N + +IA AF L L L
Sbjct: 307 EGIVEIR---LEQNSIKAIPAGAFTQYKKLKRIDISKNQ-ISDIAPDAF-QGLKSLTSLV 361
Query: 344 LSFNYIKGSYPQHINISRN-FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLG 402
L N I I++ F L+SL+ L L LR + FQ L NL+ ++L
Sbjct: 362 LYGNKI-------TEIAKGLFDGLVSLQLLLLNANKINCLRVNTFQ---DLQNLNLLSLY 411
Query: 403 INFIKQIDFKLFQNFSNLEIIYLSENRISPLVKD--------------TRQSYANSSSFQ 448
N ++ I LF +++ ++L++N P V D S A SS +
Sbjct: 412 DNKLQTISKGLFAPLQSIQTLHLAQN---PFVCDCHLKWLADYLQDNPIETSGARCSSPR 468
Query: 449 RHIRKR----RSTDFEF----DPHSNFYH--FTRPLIKPQCAAYGKALDLSLNSIFFI-- 496
R KR +S F D S F F + +C G +D S + I
Sbjct: 469 RLANKRISQIKSKKFRCSGSEDYRSRFSSECFMDLVCPEKCRCEGTIVDCSNQKLVRIPS 528
Query: 497 --------------------GPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
F+ LP++ +NLS N +V G F V+ L
Sbjct: 529 HLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKINLSNNKIKEVREGA-FDGAASVQELM 587
Query: 537 LTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNI 596
LT N+L+ + LS L+ L L N + G + F +++++L+L N I
Sbjct: 588 LTGNQLETVHGRVFRGLSGLKTLMLRSN-----LIGCVSNDTF-AGLSSVRLLSLYDNRI 641
Query: 597 YTL-----TDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKG---------LKNLT 642
T+ T +L + +L+ F+ N + W R I G LK +
Sbjct: 642 TTITPGAFTTLVSLSTINLLSNPFNCN-CHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIP 700
Query: 643 RLDLSLNRLKHIPNEAF------------------------------LNLPASLTELHIN 672
D+++ NE +P +TEL++
Sbjct: 701 IQDVAIQDFTCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLE 760
Query: 673 DNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFL 732
N L L L L+DL N + LT+ S L TL+LS+NR+ +P
Sbjct: 761 GNHLTAVP-RELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIPVHAF 819
Query: 733 SEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLN 792
+ + SL+ L L N + ++ + + T LS L L NP C C + RW+ E +
Sbjct: 820 NGLRSLRVLTLHGNDISSVPEGSF--NDLTSLSHLALGTNPLHCDCSL----RWLSEWVK 873
Query: 793 VKIPRLVDVICASP 806
C+SP
Sbjct: 874 AGYKEPGIARCSSP 887
Score = 80.1 bits (196), Expect = 1e-14
Identities = 142/627 (22%), Positives = 244/627 (38%), Gaps = 79/627 (12%)
Query: 31 SRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLT 90
+ S C + I +C + L E+P + + + E+ L N I I +F + L
Sbjct: 275 ANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQYKKLK 334
Query: 91 KINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTE 150
+I+++ N +I AF LK+L L+L N++ +I GL + L
Sbjct: 335 RIDISKN--------------QISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVS 380
Query: 151 LSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSF 210
L L+ N I ++ +L+NL L + Y NK+ I G+F L +++ L L+
Sbjct: 381 LQLLLLNANKINCLRVNTFQDLQNLNLL-SLYDNKL---QTISKGLFAPLQSIQTLHLAQ 436
Query: 211 NSL---SHV--------------------PPKLPSSLRKLFLSNTQIKYISEEDFKGLIN 247
N H+ P+ ++ R + + + + ED++ +
Sbjct: 437 NPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKFRCSGSEDYRSRFS 496
Query: 248 L-TLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAW 306
+DL CP V C + I + +T LR LN + S+ +
Sbjct: 497 SECFMDLV--CPEKCRCEGTIVDCSNQKLVRIPSHLPEYVTDLR-LNDNEVSVLEATGI- 552
Query: 307 FKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKL 366
FK +P+L+ ++L N + E+ GAF E++ L+ N ++ + R F L
Sbjct: 553 FKKLPNLRKINLS-NNKIKEVREGAFDGAASVQELM-LTGNQLETVH------GRVFRGL 604
Query: 367 LSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLS 426
L+ L LR + + D F L + LS + I I F + S + ++
Sbjct: 605 SGLKTLMLRSNLIGCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNP 664
Query: 427 EN---RISPLVKDTRQSYANSSS-------FQRH--IRKRRSTDFEFDPHSNFYHFTRPL 474
N ++ L K R+ S + F + I+ DF D + P
Sbjct: 665 FNCNCHLAWLGKWLRKRRIVSGNPRCQKPFFLKEIPIQDVAIQDFTCDGNEESSCQLSPR 724
Query: 475 IKPQCAAYGKALDLSLNSIFFIGPNQFENLP-DIACLNLSANSNAQVLSGTEFSAIPHVK 533
QC + S + + +P D+ L L N V E SA+ H+
Sbjct: 725 CPEQCTCMETVVRCSNKGLRALP----RGMPKDVTELYLEGNHLTAV--PRELSALRHLT 778
Query: 534 YLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSH 593
+DL+NN + + +S L L LSYN R+ + H +L+VL L
Sbjct: 779 LIDLSNNSISMLTNYTFSNMSHLSTLILSYN----RLRCIPVHA--FNGLRSLRVLTLHG 832
Query: 594 NNIYTLTDKYNLESKSLVELVFSGNRL 620
N+I ++ + + SL L N L
Sbjct: 833 NDISSVPEGSFNDLTSLSHLALGTNPL 859
Score = 70.1 bits (170), Expect = 1e-11
Identities = 112/471 (23%), Positives = 176/471 (37%), Gaps = 73/471 (15%)
Query: 358 NISR----NFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKL 413
NI+R +F+ L +LR LHL + FQ L QL L L N ++ + L
Sbjct: 72 NITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERL---RLNKNKLQVLPELL 128
Query: 414 FQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRP 473
FQ+ L + LSEN+I + R+++ R TD
Sbjct: 129 FQSTPKLTRLDLSENQIQGI---PRKAF------------RGITDV-------------- 159
Query: 474 LIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVK 533
K L L N I I F L D+ L L+ N+ +++L T F+ +P ++
Sbjct: 160 ----------KNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILV-TSFNHMPKIR 208
Query: 534 YLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLS- 592
L L +N L D L++ S + R +L+ N++
Sbjct: 209 TLRLHSNHLYCD-------------CHLAWLSDWLRQRRTVGQFTLCMAPVHLRGFNVAD 255
Query: 593 -HNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNL----TRLDLS 647
Y ++ + + N D R + + NL + L
Sbjct: 256 VQKKEYVCPAPHSEPPSCNANSISCPSPCTCSNNIVDCRGKGLMEIPANLPEGIVEIRLE 315
Query: 648 LNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL 707
N +K IP AF L + I+ N + Q L L L GNK+ + L
Sbjct: 316 QNSIKAIPAGAFTQYK-KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGL 374
Query: 708 SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSML 767
D SL+ LLL+ N+I+ L ++ +L L L N L+TI+K + L
Sbjct: 375 FDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLF--APLQSIQTL 432
Query: 768 ELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE 818
L NPF C C + +W+ ++L C+SP K I ++
Sbjct: 433 HLAQNPFVCDCHL----KWLADYLQDNPIETSGARCSSPRRLANKRISQIK 479
Score = 63.9 bits (154), Expect = 7e-10
Identities = 54/203 (26%), Positives = 89/203 (43%), Gaps = 7/203 (3%)
Query: 616 SGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNM 675
+ RLD+ N+ F GLKNL L L N++ I AF +L L L +N N
Sbjct: 62 NAERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQVSVIERGAFQDL-KQLERLRLNKNK 120
Query: 676 LKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEV 735
L+ L Q P+L LDL N++ + + ++ L L +N IS + G +
Sbjct: 121 LQVLPELLFQSTPKLTRLDLSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRAL 180
Query: 736 SSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKI 795
L+ L L++N + I ++ K+ L LH N C C + W+ + L +
Sbjct: 181 RDLEILTLNNNNISRILVTSF--NHMPKIRTLRLHSNHLYCDCHLA----WLSDWLRQRR 234
Query: 796 PRLVDVICASPGDQRGKSIVSLE 818
+C +P RG ++ ++
Sbjct: 235 TVGQFTLCMAPVHLRGFNVADVQ 257
Score = 55.1 bits (131), Expect = 3e-07
Identities = 48/164 (29%), Positives = 80/164 (48%), Gaps = 20/164 (12%)
Query: 21 SCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITN 80
+C+ E + S C E+ + CSN+ L+ +P+ + K VTEL L N +T +
Sbjct: 710 TCDGNEESSCQLSPRCPEQCTCMETVVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVPR 769
Query: 81 ESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQI 140
E L++LT I+L++N +T+ F N+ +L L+L N+L I
Sbjct: 770 E-LSALRHLTLIDLSNNSISM--------------LTNYTFSNMSHLSTLILSYNRLRCI 814
Query: 141 P----SGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWN 180
P +GL SL L+L N+I ++ + + L +L +L L N
Sbjct: 815 PVHAFNGL-RSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTN 857
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 114 bits (285), Expect = 5e-25
Identities = 220/935 (23%), Positives = 347/935 (37%), Gaps = 209/935 (22%)
Query: 48 ECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNP 107
+C L+ VP+ + + LDL+ N IT IT F GL++L + L N
Sbjct: 40 DCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQLMENKIS------- 92
Query: 108 GIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGL---PESLTELSLIQNNIYNITKE 164
I GAF +LK L L L N L P L L L L +N I I ++
Sbjct: 93 -------TIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRK 145
Query: 165 GISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVP------- 217
+++KNL L +N + + IEDG F L +LE+L+L+ N+++ +
Sbjct: 146 AFRGAVDIKNLQLDYN-------QISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHM 198
Query: 218 PKL-------------------------------------PSSLRKLFLSNTQIKYISEE 240
PKL PS LR ++ Q +
Sbjct: 199 PKLRTFRLHSNNLYCDCHLAWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCS 258
Query: 241 DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR 300
+ + + L +CP V C G I + +T++R L +++
Sbjct: 259 GHQSFMAPSCSVL--HCPAACTCSNNIVDCRGKGLTEIPTNLPETITEIR---LEQNTIK 313
Query: 301 KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS 360
I F L+ +DL N + E+A AF L L L L N I P+ +
Sbjct: 314 VIPPGAFSPYKKLRRIDLSNNQ-ISELAPDAFQG-LRSLNSLVLYGNKIT-ELPKSL--- 367
Query: 361 RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL 420
F L SL+ L L LR D FQ L NL+ ++L N ++ I F +
Sbjct: 368 --FEGLFSLQLLLLNANKINCLRVDAFQ---DLHNLNLLSLYDNKLQTIAKGTFSPLRAI 422
Query: 421 EIIYLSENRISPLVKDTRQSY--------------ANSSSFQRHIRKR----RSTDFE-- 460
+ ++L++N P + D + A +S +R KR +S F
Sbjct: 423 QTMHLAQN---PFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCS 479
Query: 461 -----FDPHSNFYH-------FTRPLIKPQCAAYGKALDLS---LNSI----------FF 495
F P + Y F +C G +D S LN I
Sbjct: 480 AKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELR 539
Query: 496 IGPNQF---------ENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDN 546
+ N+F + LP + +N S N + G F V + LT+NRL+
Sbjct: 540 LNNNEFTVLEATGIFKKLPQLRKINFSNNKITDIEEGA-FEGASGVNEILLTSNRLENVQ 598
Query: 547 ASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKY--N 604
L L+ L L N RI V + FI +++++L+L N I T+
Sbjct: 599 HKMFKGLESLKTLMLRSN----RITCVGND-SFI-GLSSVRLLSLYDNQITTVAPGAFDT 652
Query: 605 LESKSLVEL----------------------VFSGNRL-------------DILWND--- 626
L S S + L + +GN D+ D
Sbjct: 653 LHSLSTLNLLANPFNCNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTC 712
Query: 627 ----DDNRYISIFKGLKNLTRLDL----SLNRLKHIPNEAFLNLPASLTELHINDNMLKF 678
DDN + + T LD S LK +P +P +TEL+++ N
Sbjct: 713 DDGNDDNSCSPLSRCPTECTCLDTVVRCSNKGLKVLPK----GIPRDVTELYLDGNQFTL 768
Query: 679 FNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSL 738
L + L L+DL N++ L++ + L TL+LS+NR+ +P + SL
Sbjct: 769 VPKEL-SNYKHLTLIDLSNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSL 827
Query: 739 KHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRL 798
+ L L N + + + A + LS L + NP C C++ +W+ + + +
Sbjct: 828 RLLSLHGNDISVVPEGAF--NDLSALSHLAIGANPLYCDCNM----QWLSDWVKSEYKEP 881
Query: 799 VDVICASPGDQRGKSIVSL--ELTTCVSDVTAVIL 831
CA PG+ K +++ + TC V IL
Sbjct: 882 GIARCAGPGEMADKLLLTTPSKKFTCQGPVDVNIL 916
Score = 79.0 bits (193), Expect = 2e-14
Identities = 94/381 (24%), Positives = 161/381 (42%), Gaps = 50/381 (13%)
Query: 36 CDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHI-TNESFQGLQNLTKINL 94
C EK + + +CSN++L ++P+ + +Y EL L++N T + F+ L L KIN
Sbjct: 506 CPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKINF 565
Query: 95 NHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLI 154
++N +I +GAF + E+LL N+L + + + L L +
Sbjct: 566 SNNKIT--------------DIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTL 611
Query: 155 QNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLS 214
IT G I L ++ L + Y N++ T + G F+TL +L L+L N +
Sbjct: 612 MLRSNRITCVGNDSFIGLSSVRLL-SLYDNQI---TTVAPGAFDTLHSLSTLNLLANPFN 667
Query: 215 ---------------HVPPKLPSSLRKLFLSNTQIKYISEEDF---KGLINLTLLDLSGN 256
+ P + FL I+ ++ +DF G + + LS
Sbjct: 668 CNCYLAWLGEWLRKKRIVTGNPRCQKPYFLKEIPIQDVAIQDFTCDDGNDDNSCSPLS-R 726
Query: 257 CPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL 316
CP V C + + +++T+L YL+ + +L N HL ++
Sbjct: 727 CPTECTCLDTVVRCSNKGLKVLPKGIPRDVTEL-YLDGNQFTLVPKE---LSNYKHLTLI 782
Query: 317 DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 376
DL N + +++ +F M L ++ LS+N ++ P R F L SLR L L G
Sbjct: 783 DLS-NNRISTLSNQSFSNMTQLLTLI-LSYNRLRCIPP------RTFDGLKSLRLLSLHG 834
Query: 377 YVFQELREDDFQPLMQLPNLS 397
+ E F L L +L+
Sbjct: 835 NDISVVPEGAFNDLSALSHLA 855
Score = 68.6 bits (166), Expect = 3e-11
Identities = 143/623 (22%), Positives = 234/623 (37%), Gaps = 92/623 (14%)
Query: 46 IAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNG 105
I +C + L E+P + + +TE+ L N I I +F + L +I+L++N +
Sbjct: 283 IVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDLSNNQISE---- 338
Query: 106 NPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEG 165
+ AF L++L L+L N++ ++P L E L L L+ N I
Sbjct: 339 ----------LAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLR 388
Query: 166 ISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFN------------SL 213
+ +L NL L + Y NK+ I G F L ++ + L+ N
Sbjct: 389 VDAFQDLHNLNLL-SLYDNKL---QTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADY 444
Query: 214 SHVPPKLPSSLR---KLFLSNTQIKYISEEDFKGLINLTLL---------DLSGNCPRCF 261
H P S R L+N +I I + F+ LSG+C
Sbjct: 445 LHTNPIETSGARCTSPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYRSKLSGDCFADL 504
Query: 262 NAPFPC------VPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKV 315
P C V C I Q +LR N T L FK +P L+
Sbjct: 505 ACPEKCRCEGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGI--FKKLPQLRK 562
Query: 316 LDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLR 375
++ N + +I GAF EIL L+ N ++ QH + F L SL+ L LR
Sbjct: 563 INFS-NNKITDIEEGAFEGASGVNEIL-LTSNRLEN--VQH----KMFKGLESLKTLMLR 614
Query: 376 GYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEII------------ 423
+ D F L + LS + I + F + S L ++
Sbjct: 615 SNRITCVGNDSFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAW 674
Query: 424 ---YLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIK--PQ 478
+L + RI ++ Y + I+ DF D N + PL + +
Sbjct: 675 LGEWLRKKRIVTGNPRCQKPYFLK---EIPIQDVAIQDFTCD-DGNDDNSCSPLSRCPTE 730
Query: 479 CAAYGKALDLSLNSIFFIGPNQFENLP-DIACLNLSANSNAQVLSGTEFSAIPHVKYLDL 537
C + S + + + +P D+ L L + N L E S H+ +DL
Sbjct: 731 CTCLDTVVRCSNKGLKVLP----KGIPRDVTELYL--DGNQFTLVPKELSNYKHLTLIDL 784
Query: 538 TNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIY 597
+NNR+ + + + ++ L L LSYN R+ + +L++L+L N+I
Sbjct: 785 SNNRISTLSNQSFSNMTQLLTLILSYN----RLRCIPPRT--FDGLKSLRLLSLHGNDIS 838
Query: 598 TLTDKYNLESKSLVELVFSGNRL 620
+ + + +L L N L
Sbjct: 839 VVPEGAFNDLSALSHLAIGANPL 861
Score = 48.1 bits (113), Expect = 4e-05
Identities = 77/360 (21%), Positives = 135/360 (37%), Gaps = 97/360 (26%)
Query: 478 QCAAYGKALD---LSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKY 534
QC+ G +D L+L S+ P E L +L+ N N ++ T+F+ + H++
Sbjct: 31 QCSCSGSTVDCHGLALRSVPRNIPRNTERL------DLNGN-NITRITKTDFAGLRHLRV 83
Query: 535 LDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNF-----TNLKVL 589
L L N++ A +L +LE L L+ N HL+ L L
Sbjct: 84 LQLMENKISTIERGAFQDLKELERLRLNRN-----------HLQLFPELLFLGTAKLYRL 132
Query: 590 NLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLN 649
+LS N I + K + + L N++ + + F+ L++L L L+ N
Sbjct: 133 DLSENQIQAIPRKAFRGAVDIKNLQLDYNQISCIED-------GAFRALRDLEVLTLNNN 185
Query: 650 RLKHIPNEAFLNLPASLT-ELHIND-----NMLKFFNWTLLQQFPRL------------- 690
+ + +F ++P T LH N+ ++ +W L+Q PR+
Sbjct: 186 NITRLSVASFNHMPKLRTFRLHSNNLYCDCHLAWLSDW--LRQRPRVGLYTQCMGPSHLR 243
Query: 691 --------------------------------------ELLDLRGNKLLFLTDSLSDFTS 712
++D RG L + +L + +
Sbjct: 244 GHNVAEVQKREFVCSGHQSFMAPSCSVLHCPAACTCSNNIVDCRGKGLTEIPTNLPETIT 303
Query: 713 SLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 772
+R L N I +P G S L+ +DLS+N + + A + L+ L L+GN
Sbjct: 304 EIR---LEQNTIKVIPPGAFSPYKKLRRIDLSNNQISELAPDAFQ--GLRSLNSLVLYGN 358
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 110 bits (276), Expect = 5e-24
Identities = 191/731 (26%), Positives = 292/731 (39%), Gaps = 143/731 (19%)
Query: 137 LPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGV 196
L Q+PS LP L L N + +I + L++L L+ N E + ++ G
Sbjct: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN-------EISFLQPGA 92
Query: 197 FETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN 256
F+ LT+LE LSL+ N L+ +S L +T LDLSGN
Sbjct: 93 FQALTHLEHLSLAHNRLAMATA------------------LSAGGLGPLPRVTSLDLSGN 134
Query: 257 CPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL 316
S ++R + L L+L+ SL ++ F++MP L+ L
Sbjct: 135 SLY---------------SGLLERLLGE-APSLHTLSLAENSLTRLTRHTFRDMPALEQL 178
Query: 317 DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 376
DL N L+ +I GAF LPRL L+LS N S + S ++L L +
Sbjct: 179 DLHSNVLM-DIEDGAF-EGLPRLTHLNLSRN----SLTCISDFSLQQLRVLDLSCNSIEA 232
Query: 377 YVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRI---SPL 433
+ + +FQ L+ ++L N K + F L + LS N I +
Sbjct: 233 FQTASQPQAEFQ-------LTWLDLREN--KLLHFPDLAALPRLIYLNLSNNLIRLPTGP 283
Query: 434 VKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKAL------D 487
+D++ +A S + PL P A G+ L D
Sbjct: 284 PQDSKGIHAPSEGWS----------------------ALPLSAPSGNASGRPLSQLLNLD 321
Query: 488 LSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNA 547
LS N I I + E+L + LNLS N + ++P + LDL++N L
Sbjct: 322 LSYNEIELIPDSFLEHLTSLCFLNLSRNC-LRTFEARRLGSLPCLMLLDLSHNAL----- 375
Query: 548 SALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLES 607
E L+L + +L+ L L N + L
Sbjct: 376 ---------ETLELGARA-----------------LGSLRTLLLQGNALRDLPPYTFANL 409
Query: 608 KSLVELVFSGNRLDILWNDDDNRYISI--FKGLKNLTRLDLSLNRLKHIPNEAFLNLPAS 665
SL L GNR+ D+ F G+ +L L L N ++ + AFL+ P
Sbjct: 410 ASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-- 467
Query: 666 LTELHINDNM-LKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRI 724
LTEL ++ N L+ L LE+L L+GN L+ L L F L+ L L+ NR+
Sbjct: 468 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFIC-LKRLNLAENRL 526
Query: 725 SHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFR 784
SHLP+ ++ SL+ LDL +N + SA+ T L L L GNP C C G
Sbjct: 527 SHLPA--WTQAVSLEVLDLRNNSFSLLPGSAM-GGLETSLRRLYLQGNPLSC-CGNG--- 579
Query: 785 RWMDEHLN---VKIPRLVDVICASPGDQRGKSIVSLELTTC----VSDVTAVILFFFTFF 837
W+ L+ V + D+IC Q S+ + C + ++ +I+ TF
Sbjct: 580 -WLAAQLHQGRVDVDATQDLICRF-SSQEEVSLSHVRPEDCEKGGLKNINLIII--LTFI 635
Query: 838 ITTMVMLAALA 848
+ + ++L LA
Sbjct: 636 LVSAILLTTLA 646
Score = 67.8 bits (164), Expect = 5e-11
Identities = 140/551 (25%), Positives = 219/551 (39%), Gaps = 81/551 (14%)
Query: 43 DSVIAECSNRRLQEV-PQTVGKYVT--ELDLSDNFITHITNESFQGLQNLTKINLNHNPN 99
D+ + S +L+ + +G Y LDLS N I+ + +FQ L +L ++L HN
Sbjct: 50 DTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL 109
Query: 100 VQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPE-------SLTELS 152
++ G L + L L N L SGL E SL LS
Sbjct: 110 AM-----------ATALSAGGLGPLPRVTSLDLSGNSLY---SGLLERLLGEAPSLHTLS 155
Query: 153 LIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNS 212
L +N++ +T+ + L+ L L N + IEDG FE L L L+LS NS
Sbjct: 156 LAENSLTRLTRHTFRDMPALEQLDLHSNVLMD-------IEDGAFEGLPRLTHLNLSRNS 208
Query: 213 LSHVPPKLPSSLRKLFLSNTQIK-YISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCD 271
L+ + LR L LS I+ + + + LT LDL N + + P
Sbjct: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLREN--KLLHFP------- 259
Query: 272 GGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASG- 330
L +L YLNLS+ +R + ++ + ++ L SG
Sbjct: 260 ----------DLAALPRLIYLNLSNNLIR-LPTGPPQDSKGIHAPSEGWSALPLSAPSGN 308
Query: 331 AFLTMLPRLEILDLSFNYIK---GSYPQHI------NISRNFSKLLSLRAL-HLRGYVFQ 380
A L +L LDLS+N I+ S+ +H+ N+SRN + R L L +
Sbjct: 309 ASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLL 368
Query: 381 ELREDDFQPL----MQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKD 436
+L + + L L +L T+ L N ++ + F N ++L+ + L NR+SP
Sbjct: 369 DLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP 428
Query: 437 TRQSYANSSSFQ--RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIF 494
+ +F +R D E + PL + LDLS N
Sbjct: 429 DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTE---------LDLSSNPGL 479
Query: 495 FIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELS 554
+ L + + L+ N ++ + +K L+L NRL + A T+
Sbjct: 480 EVATGALGGL-EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRL--SHLPAWTQAV 536
Query: 555 DLEVLDLSYNS 565
LEVLDL NS
Sbjct: 537 SLEVLDLRNNS 547
Score = 61.6 bits (148), Expect = 4e-09
Identities = 80/268 (29%), Positives = 119/268 (44%), Gaps = 38/268 (14%)
Query: 507 IACLNLSANSNAQVLSGTEFSAI--PHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 564
+ C + + QVL + ++ P + LDL+ N+L AS L + L LDLS N
Sbjct: 24 VPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN 83
Query: 565 SHYFRIAG----VTH--HLEFIQN---------------FTNLKVLNLSHNNIYT-LTDK 602
F G +TH HL N + L+LS N++Y+ L ++
Sbjct: 84 EISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLER 143
Query: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
E+ SL L + N L L F+ + L +LDL N L I + AF L
Sbjct: 144 LLGEAPSLHTLSLAENSLTRLTR-------HTFRDMPALEQLDLHSNVLMDIEDGAFEGL 196
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL-LFLTDSLSDFTSSLRTLLLSH 721
P LT L+++ N L + LQQ L +LDL N + F T S L L L
Sbjct: 197 P-RLTHLNLSRNSLTCISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRE 252
Query: 722 NRISHLPSGFLSEVSSLKHLDLSSNLLK 749
N++ H P L+ + L +L+LS+NL++
Sbjct: 253 NKLLHFPD--LAALPRLIYLNLSNNLIR 278
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 110 bits (276), Expect = 5e-24
Identities = 191/731 (26%), Positives = 292/731 (39%), Gaps = 143/731 (19%)
Query: 137 LPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGV 196
L Q+PS LP L L N + +I + L++L L+ N E + ++ G
Sbjct: 40 LLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN-------EISFLQPGA 92
Query: 197 FETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN 256
F+ LT+LE LSL+ N L+ +S L +T LDLSGN
Sbjct: 93 FQALTHLEHLSLAHNRLAMATA------------------LSAGGLGPLPRVTSLDLSGN 134
Query: 257 CPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL 316
S ++R + L L+L+ SL ++ F++MP L+ L
Sbjct: 135 SLY---------------SGLLERLLGE-APSLHTLSLAENSLTRLTRHTFRDMPALEQL 178
Query: 317 DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 376
DL N L+ +I GAF LPRL L+LS N S + S ++L L +
Sbjct: 179 DLHSNVLM-DIEDGAF-EGLPRLTHLNLSRN----SLTCISDFSLQQLRVLDLSCNSIEA 232
Query: 377 YVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRI---SPL 433
+ + +FQ L+ ++L N K + F L + LS N I +
Sbjct: 233 FQTASQPQAEFQ-------LTWLDLREN--KLLHFPDLAALPRLIYLNLSNNLIRLPTGP 283
Query: 434 VKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKAL------D 487
+D++ +A S + PL P A G+ L D
Sbjct: 284 PQDSKGIHAPSEGWS----------------------ALPLSAPSGNASGRPLSQLLNLD 321
Query: 488 LSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNA 547
LS N I I + E+L + LNLS N + ++P + LDL++N L
Sbjct: 322 LSYNEIELIPDSFLEHLTSLCFLNLSRNC-LRTFEARRLGSLPCLMLLDLSHNAL----- 375
Query: 548 SALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLES 607
E L+L + +L+ L L N + L
Sbjct: 376 ---------ETLELGARA-----------------LGSLRTLLLQGNALRDLPPYTFANL 409
Query: 608 KSLVELVFSGNRLDILWNDDDNRYISI--FKGLKNLTRLDLSLNRLKHIPNEAFLNLPAS 665
SL L GNR+ D+ F G+ +L L L N ++ + AFL+ P
Sbjct: 410 ASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTP-- 467
Query: 666 LTELHINDNM-LKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRI 724
LTEL ++ N L+ L LE+L L+GN L+ L L F L+ L L+ NR+
Sbjct: 468 LTELDLSSNPGLEVATGALGGLEASLEVLALQGNGLMVLQVDLPCFIC-LKRLNLAENRL 526
Query: 725 SHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFR 784
SHLP+ ++ SL+ LDL +N + SA+ T L L L GNP C C G
Sbjct: 527 SHLPA--WTQAVSLEVLDLRNNSFSLLPGSAM-GGLETSLRRLYLQGNPLSC-CGNG--- 579
Query: 785 RWMDEHLN---VKIPRLVDVICASPGDQRGKSIVSLELTTC----VSDVTAVILFFFTFF 837
W+ L+ V + D+IC Q S+ + C + ++ +I+ TF
Sbjct: 580 -WLAAQLHQGRVDVDATQDLICRF-SSQEEVSLSHVRPEDCEKGGLKNINLIII--LTFI 635
Query: 838 ITTMVMLAALA 848
+ + ++L LA
Sbjct: 636 LVSAILLTTLA 646
Score = 67.8 bits (164), Expect = 5e-11
Identities = 140/551 (25%), Positives = 219/551 (39%), Gaps = 81/551 (14%)
Query: 43 DSVIAECSNRRLQEV-PQTVGKYVT--ELDLSDNFITHITNESFQGLQNLTKINLNHNPN 99
D+ + S +L+ + +G Y LDLS N I+ + +FQ L +L ++L HN
Sbjct: 50 DTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL 109
Query: 100 VQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPE-------SLTELS 152
++ G L + L L N L SGL E SL LS
Sbjct: 110 AM-----------ATALSAGGLGPLPRVTSLDLSGNSLY---SGLLERLLGEAPSLHTLS 155
Query: 153 LIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNS 212
L +N++ +T+ + L+ L L N + IEDG FE L L L+LS NS
Sbjct: 156 LAENSLTRLTRHTFRDMPALEQLDLHSNVLMD-------IEDGAFEGLPRLTHLNLSRNS 208
Query: 213 LSHVPPKLPSSLRKLFLSNTQIK-YISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCD 271
L+ + LR L LS I+ + + + LT LDL N + + P
Sbjct: 209 LTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLREN--KLLHFP------- 259
Query: 272 GGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASG- 330
L +L YLNLS+ +R + ++ + ++ L SG
Sbjct: 260 ----------DLAALPRLIYLNLSNNLIR-LPTGPPQDSKGIHAPSEGWSALPLSAPSGN 308
Query: 331 AFLTMLPRLEILDLSFNYIK---GSYPQHI------NISRNFSKLLSLRAL-HLRGYVFQ 380
A L +L LDLS+N I+ S+ +H+ N+SRN + R L L +
Sbjct: 309 ASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLL 368
Query: 381 ELREDDFQPL----MQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKD 436
+L + + L L +L T+ L N ++ + F N ++L+ + L NR+SP
Sbjct: 369 DLSHNALETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGP 428
Query: 437 TRQSYANSSSFQ--RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIF 494
+ +F +R D E + PL + LDLS N
Sbjct: 429 DEPGPSGCVAFSGITSLRSLSLVDNEIELLRAGAFLHTPLTE---------LDLSSNPGL 479
Query: 495 FIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELS 554
+ L + + L+ N ++ + +K L+L NRL + A T+
Sbjct: 480 EVATGALGGL-EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRL--SHLPAWTQAV 536
Query: 555 DLEVLDLSYNS 565
LEVLDL NS
Sbjct: 537 SLEVLDLRNNS 547
Score = 61.6 bits (148), Expect = 4e-09
Identities = 80/268 (29%), Positives = 119/268 (44%), Gaps = 38/268 (14%)
Query: 507 IACLNLSANSNAQVLSGTEFSAI--PHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYN 564
+ C + + QVL + ++ P + LDL+ N+L AS L + L LDLS N
Sbjct: 24 VPCKMVDKKVSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTN 83
Query: 565 SHYFRIAG----VTH--HLEFIQN---------------FTNLKVLNLSHNNIYT-LTDK 602
F G +TH HL N + L+LS N++Y+ L ++
Sbjct: 84 EISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLER 143
Query: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
E+ SL L + N L L F+ + L +LDL N L I + AF L
Sbjct: 144 LLGEAPSLHTLSLAENSLTRLTR-------HTFRDMPALEQLDLHSNVLMDIEDGAFEGL 196
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL-LFLTDSLSDFTSSLRTLLLSH 721
P LT L+++ N L + LQQ L +LDL N + F T S L L L
Sbjct: 197 P-RLTHLNLSRNSLTCISDFSLQQ---LRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRE 252
Query: 722 NRISHLPSGFLSEVSSLKHLDLSSNLLK 749
N++ H P L+ + L +L+LS+NL++
Sbjct: 253 NKLLHFPD--LAALPRLIYLNLSNNLIR 278
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 109 bits (272), Expect = 2e-23
Identities = 115/399 (28%), Positives = 170/399 (42%), Gaps = 45/399 (11%)
Query: 48 ECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNP 107
EC+ R+ VP + L + + IT + F + L + + N +
Sbjct: 44 ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSR------ 97
Query: 108 GIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGL---PESLTELSLIQNNIYNITKE 164
IT GAF NL +LR L L +N+L +P GL +SL L L N + I
Sbjct: 98 --------ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149
Query: 165 GISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKL---P 221
S+ NLK L L N I DG F+ L L L+L NSL+H+ P++
Sbjct: 150 HFSQCSNLKELQLHGN-------HLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHL 202
Query: 222 SSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN-----CPRCF--NAPFPCVPCDGGA 274
+L+ L L ++ I F GL+NL L L N P F N +
Sbjct: 203 GNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNH 262
Query: 275 SINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLT 334
+ F L QL L L SL++++ F MP+L+ L L N+ + + F +
Sbjct: 263 ISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH-ISSLPDNVF-S 320
Query: 335 MLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLP 394
L +L++L LS N I P F+ L LR L L Q+L + F+ L L
Sbjct: 321 NLRQLQVLILSRNQISFISP------GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 374
Query: 395 NLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPL 433
N+S N N ++Q+ +F N + L I L N++ L
Sbjct: 375 NISLQN---NRLRQLPGNIFANVNGLMAIQLQNNQLENL 410
Score = 94.7 bits (234), Expect = 4e-19
Identities = 112/415 (26%), Positives = 178/415 (42%), Gaps = 49/415 (11%)
Query: 283 FQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEIL 342
F N++ L L + L +I F+N+ L+ L L N L ++ L LE L
Sbjct: 79 FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL--QVLPIGLFQGLDSLESL 136
Query: 343 DLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLG 402
LS N + P H FS+ +L+ L L G + + + F L+ L+ +NLG
Sbjct: 137 LLSSNQLLQIQPAH------FSQCSNLKELQLHGNHLEYIPDGAFDHLV---GLTKLNLG 187
Query: 403 INFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFD 462
N + I ++FQ+ NL+++ L ENR++ + T N + + +++
Sbjct: 188 KNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN----LQELALQQNQIGLLS 243
Query: 463 PHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLS 522
P +H L + L LS N I + P+ F LP + L L NS ++
Sbjct: 244 P--GLFHNNHNL---------QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSL 292
Query: 523 GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQN 582
G F +P+++ L L +N + + + L L+VL LS N F G + L
Sbjct: 293 GI-FGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL----- 346
Query: 583 FTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLT 642
T L+ L+L N + L +L + NRL L +IF + L
Sbjct: 347 -TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG-------NIFANVNGLM 398
Query: 643 RLDLSLNRLKHIPNEAFLNLPASLTELHINDN-------MLKFFNWTLLQQFPRL 690
+ L N+L+++P F +L L EL + DN +L NW LL Q PRL
Sbjct: 399 AIQLQNNQLENLPLGIFDHL-GKLCELRLYDNPWRCDSDILPLRNWLLLNQ-PRL 451
Score = 91.7 bits (226), Expect = 3e-18
Identities = 113/467 (24%), Positives = 185/467 (39%), Gaps = 66/467 (14%)
Query: 363 FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEI 422
F + +L AL + + F+ L L LS N N ++ + LFQ +LE
Sbjct: 79 FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN---NKLQVLPIGLFQGLDSLES 135
Query: 423 IYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAY 482
+ LS N++ + +N Q H E+ P F H L K
Sbjct: 136 LLLSSNQLLQIQPAHFSQCSNLKELQLH-----GNHLEYIPDGAFDHLVG-LTK------ 183
Query: 483 GKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL 542
L+L NS+ I P F++L ++ L L N + GT F + +++ L L N++
Sbjct: 184 ---LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGT-FDGLVNLQELALQQNQI 239
Query: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
+ +L+ L LS N+H ++ L L L N++ L+
Sbjct: 240 GLLSPGLFHNNHNLQRLYLS-NNHISQLPP-----SIFMQLPQLNRLTLFGNSLKELSLG 293
Query: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
+L EL N + L DN +F L+ L L LS N++ I AF L
Sbjct: 294 IFGPMPNLRELWLYDNHISSL---PDN----VFSNLRQLQVLILSRNQISFISPGAFNGL 346
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHN 722
L EL ++ N L+ + + + L+ + L+ N+L L ++ + L + L +N
Sbjct: 347 -TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNN 405
Query: 723 RISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGD 782
++ +LP G + KL L L+ NP+ C DI
Sbjct: 406 QLENLPLGIFDHLG--------------------------KLCELRLYDNPWRCDSDILP 439
Query: 783 FRRWMDEHLNVKIPRL---VDVICASPGDQRGKSIVSLELTTCVSDV 826
R W L + PRL +C SP + RG+S++ + + V V
Sbjct: 440 LRNW----LLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSV 482
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/118 (30%), Positives = 49/118 (41%), Gaps = 1/118 (0%)
Query: 640 NLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNK 699
N L + + + FLN+ A L L I N L + L L L NK
Sbjct: 60 NAMSLQILNTHITELNESPFLNISA-LIALRIEKNELSRITPGAFRNLGSLRYLSLANNK 118
Query: 700 LLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALE 757
L L L SL +LLLS N++ + S+ S+LK L L N L+ I A +
Sbjct: 119 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 176
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 2/114 (1%)
Query: 662 LPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH 721
LP + L I + + N + L L + N+L +T SLR L L++
Sbjct: 57 LPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 116
Query: 722 NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFE 775
N++ LP G + SL+ L LSSN L I + + L L+LHGN E
Sbjct: 117 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA--HFSQCSNLKELQLHGNHLE 168
Score = 37.7 bits (86), Expect = 0.057
Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 15/115 (13%)
Query: 51 NRRLQEVPQTVGKYVTELD---LSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNP 107
+ + +P V + +L LS N I+ I+ +F GL L +++L+ N +Q +GN
Sbjct: 308 DNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA-LQDLDGNV 366
Query: 108 ----------GIQSNGLNITDG-AFLNLKNLRELLLEDNQLPQIPSGLPESLTEL 151
+Q+N L G F N+ L + L++NQL +P G+ + L +L
Sbjct: 367 FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL 421
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 109 bits (272), Expect = 2e-23
Identities = 115/399 (28%), Positives = 170/399 (42%), Gaps = 45/399 (11%)
Query: 48 ECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNP 107
EC+ R+ VP + L + + IT + F + L + + N +
Sbjct: 38 ECTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSR------ 91
Query: 108 GIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGL---PESLTELSLIQNNIYNITKE 164
IT GAF NL +LR L L +N+L +P GL +SL L L N + I
Sbjct: 92 --------ITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
Query: 165 GISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKL---P 221
S+ NLK L L N I DG F+ L L L+L NSL+H+ P++
Sbjct: 144 HFSQCSNLKELQLHGN-------HLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHL 196
Query: 222 SSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN-----CPRCF--NAPFPCVPCDGGA 274
+L+ L L ++ I F GL+NL L L N P F N +
Sbjct: 197 GNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNH 256
Query: 275 SINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLT 334
+ F L QL L L SL++++ F MP+L+ L L N+ + + F +
Sbjct: 257 ISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNH-ISSLPDNVF-S 314
Query: 335 MLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLP 394
L +L++L LS N I P F+ L LR L L Q+L + F+ L L
Sbjct: 315 NLRQLQVLILSRNQISFISP------GAFNGLTELRELSLHTNALQDLDGNVFRMLANLQ 368
Query: 395 NLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPL 433
N+S N N ++Q+ +F N + L I L N++ L
Sbjct: 369 NISLQN---NRLRQLPGNIFANVNGLMAIQLQNNQLENL 404
Score = 94.7 bits (234), Expect = 4e-19
Identities = 112/415 (26%), Positives = 178/415 (42%), Gaps = 49/415 (11%)
Query: 283 FQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEIL 342
F N++ L L + L +I F+N+ L+ L L N L ++ L LE L
Sbjct: 73 FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL--QVLPIGLFQGLDSLESL 130
Query: 343 DLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLG 402
LS N + P H FS+ +L+ L L G + + + F L+ L+ +NLG
Sbjct: 131 LLSSNQLLQIQPAH------FSQCSNLKELQLHGNHLEYIPDGAFDHLV---GLTKLNLG 181
Query: 403 INFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFD 462
N + I ++FQ+ NL+++ L ENR++ + T N + + +++
Sbjct: 182 KNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVN----LQELALQQNQIGLLS 237
Query: 463 PHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLS 522
P +H L + L LS N I + P+ F LP + L L NS ++
Sbjct: 238 P--GLFHNNHNL---------QRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSL 286
Query: 523 GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQN 582
G F +P+++ L L +N + + + L L+VL LS N F G + L
Sbjct: 287 GI-FGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGL----- 340
Query: 583 FTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLT 642
T L+ L+L N + L +L + NRL L +IF + L
Sbjct: 341 -TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG-------NIFANVNGLM 392
Query: 643 RLDLSLNRLKHIPNEAFLNLPASLTELHINDN-------MLKFFNWTLLQQFPRL 690
+ L N+L+++P F +L L EL + DN +L NW LL Q PRL
Sbjct: 393 AIQLQNNQLENLPLGIFDHL-GKLCELRLYDNPWRCDSDILPLRNWLLLNQ-PRL 445
Score = 91.7 bits (226), Expect = 3e-18
Identities = 113/467 (24%), Positives = 185/467 (39%), Gaps = 66/467 (14%)
Query: 363 FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEI 422
F + +L AL + + F+ L L LS N N ++ + LFQ +LE
Sbjct: 73 FLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN---NKLQVLPIGLFQGLDSLES 129
Query: 423 IYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAY 482
+ LS N++ + +N Q H E+ P F H L K
Sbjct: 130 LLLSSNQLLQIQPAHFSQCSNLKELQLH-----GNHLEYIPDGAFDHLVG-LTK------ 177
Query: 483 GKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL 542
L+L NS+ I P F++L ++ L L N + GT F + +++ L L N++
Sbjct: 178 ---LNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGT-FDGLVNLQELALQQNQI 233
Query: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
+ +L+ L LS N+H ++ L L L N++ L+
Sbjct: 234 GLLSPGLFHNNHNLQRLYLS-NNHISQLPP-----SIFMQLPQLNRLTLFGNSLKELSLG 287
Query: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
+L EL N + L DN +F L+ L L LS N++ I AF L
Sbjct: 288 IFGPMPNLRELWLYDNHISSL---PDN----VFSNLRQLQVLILSRNQISFISPGAFNGL 340
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHN 722
L EL ++ N L+ + + + L+ + L+ N+L L ++ + L + L +N
Sbjct: 341 -TELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNN 399
Query: 723 RISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGD 782
++ +LP G + KL L L+ NP+ C DI
Sbjct: 400 QLENLPLGIFDHLG--------------------------KLCELRLYDNPWRCDSDILP 433
Query: 783 FRRWMDEHLNVKIPRL---VDVICASPGDQRGKSIVSLELTTCVSDV 826
R W L + PRL +C SP + RG+S++ + + V V
Sbjct: 434 LRNW----LLLNQPRLGTDTVPVCFSPANVRGQSLIIINVNVAVPSV 476
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/118 (30%), Positives = 49/118 (41%), Gaps = 1/118 (0%)
Query: 640 NLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNK 699
N L + + + FLN+ A L L I N L + L L L NK
Sbjct: 54 NAMSLQILNTHITELNESPFLNISA-LIALRIEKNELSRITPGAFRNLGSLRYLSLANNK 112
Query: 700 LLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALE 757
L L L SL +LLLS N++ + S+ S+LK L L N L+ I A +
Sbjct: 113 LQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFD 170
Score = 42.7 bits (99), Expect = 0.002
Identities = 35/114 (30%), Positives = 51/114 (44%), Gaps = 2/114 (1%)
Query: 662 LPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSH 721
LP + L I + + N + L L + N+L +T SLR L L++
Sbjct: 51 LPWNAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLAN 110
Query: 722 NRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFE 775
N++ LP G + SL+ L LSSN L I + + L L+LHGN E
Sbjct: 111 NKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA--HFSQCSNLKELQLHGNHLE 162
Score = 37.7 bits (86), Expect = 0.057
Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 15/115 (13%)
Query: 51 NRRLQEVPQTVGKYVTELD---LSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNP 107
+ + +P V + +L LS N I+ I+ +F GL L +++L+ N +Q +GN
Sbjct: 302 DNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNA-LQDLDGNV 360
Query: 108 ----------GIQSNGLNITDG-AFLNLKNLRELLLEDNQLPQIPSGLPESLTEL 151
+Q+N L G F N+ L + L++NQL +P G+ + L +L
Sbjct: 361 FRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKL 415
>gi|4557543 extracellular matrix protein 2 precursor [Homo sapiens]
Length = 699
Score = 107 bits (268), Expect = 4e-23
Identities = 109/387 (28%), Positives = 168/387 (43%), Gaps = 48/387 (12%)
Query: 49 CSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPG 108
C N L ++P +T L+L+ N I I +E+F GL NL +++L+ N
Sbjct: 329 CINAMLTQIPPLTAPQITSLELTGNSIASIPDEAFNGLPNLERLDLSKN----------N 378
Query: 109 IQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISR 168
I S+G+ AF LK L L ++ N L QIPS LP +L EL + +NN+ I +E +S
Sbjct: 379 ITSSGIG--PKAFKLLKKLMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSD 436
Query: 169 LINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLF 228
L L L L N + N+ F+ L +L L L N +P LP S+ +L+
Sbjct: 437 LNQLVTLELEGN-----NLSEANVNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELY 491
Query: 229 LSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQ 288
L N QI+ I+E F + ++ L N I A+ N
Sbjct: 492 LENNQIEEITEICFNHTRKINVIVLRYNKIE---------------ENRIAPLAWINQEN 536
Query: 289 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNY 348
L ++LS L + + K++ HL +L + + G + F M P LE L LSFN
Sbjct: 537 LESIDLSYNKLYHVPSYLPKSLLHLVLLGNQIERIPGYV----FGHMEPGLEYLYLSFNK 592
Query: 349 IKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQ 408
+ ++ + SLR L L + + + ++ L + L N I+
Sbjct: 593 LADDGMDRVSF---YGAYHSLRELFLDHNDLKSIPPG----IQEMKALHFLRLNNNKIRN 645
Query: 409 IDFKLFQNF-----SNLEIIYLSENRI 430
I + N SNLE ++L N I
Sbjct: 646 ILPEEICNAEEDDDSNLEHLHLENNYI 672
Score = 58.9 bits (141), Expect = 2e-08
Identities = 86/350 (24%), Positives = 142/350 (40%), Gaps = 68/350 (19%)
Query: 473 PLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQV------------ 520
PL PQ + L+L+ NSI I F LP++ L+LS N+
Sbjct: 339 PLTAPQITS----LELTGNSIASIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKK 394
Query: 521 -----LSGTEFSAIPH-----VKYLDLTNNRLDFDNASALTELSDLEVLDLSYNS----- 565
+ G IP ++ L + N L + +L++L+ L L+L N+
Sbjct: 395 LMRLNMDGNNLIQIPSQLPSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEAN 454
Query: 566 ------------HYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVEL 613
Y R+ + +++ L L +N I +T+ ++ + +
Sbjct: 455 VNPLAFKPLKSLAYLRLGKNKFRIIPQGLPGSIEELYLENNQIEEITEICFNHTRKINVI 514
Query: 614 VFSGNRLDILWNDDDNRYISI-FKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHIN 672
V N++ ++NR + + +NL +DLS N+L H+P+ LP SL L +
Sbjct: 515 VLRYNKI------EENRIAPLAWINQENLESIDLSYNKLYHVPS----YLPKSLLHLVLL 564
Query: 673 DNML-KFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTS------SLRTLLLSHNRIS 725
N + + + P LE L L NK L D D S SLR L L HN +
Sbjct: 565 GNQIERIPGYVFGHMEPGLEYLYLSFNK---LADDGMDRVSFYGAYHSLRELFLDHNDLK 621
Query: 726 HLPSGFLSEVSSLKHLDLSSNLLKTINKSAL---ETKTTTKLSMLELHGN 772
+P G + E+ +L L L++N ++ I + E + L L L N
Sbjct: 622 SIPPG-IQEMKALHFLRLNNNKIRNILPEEICNAEEDDDSNLEHLHLENN 670
Score = 52.4 bits (124), Expect = 2e-06
Identities = 52/175 (29%), Positives = 83/175 (47%), Gaps = 17/175 (9%)
Query: 609 SLVELVFSG----NRLDILWNDDDNRYIS--IFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
S+ + F+G RLD+ N+ + I FK LK L RL++ N L IP++ L
Sbjct: 357 SIPDEAFNGLPNLERLDLSKNNITSSGIGPKAFKLLKKLMRLNMDGNNLIQIPSQ----L 412
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDF--TSSLRTLLLS 720
P++L EL +N+N L+ + L +L L+L GN L + F SL L L
Sbjct: 413 PSTLEELKVNENNLQAIDEESLSDLNQLVTLELEGNNLSEANVNPLAFKPLKSLAYLRLG 472
Query: 721 HNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFE 775
N+ +P G S++ L L +N ++ I + T K++++ L N E
Sbjct: 473 KNKFRIIPQGL---PGSIEELYLENNQIEEITEICF--NHTRKINVIVLRYNKIE 522
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 104 bits (260), Expect = 4e-22
Identities = 126/519 (24%), Positives = 220/519 (42%), Gaps = 83/519 (15%)
Query: 328 ASGAFLTMLP---RLEILDLS--------FNYIKGSYPQHINISRNFSKLLSLRALHLRG 376
A+GA L P R+ +LD S + + G P I LS + L
Sbjct: 37 AAGAGLCPAPCSCRIPLLDCSRRKLPAPSWRALSGLLPPDTAILDFSHNRLSNWNISLES 96
Query: 377 YVFQELREDDFQPLMQLP-------NLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENR 429
QE++ + + L ++P N++ ++L N I +I+ + Q + LE + LS N
Sbjct: 97 QTLQEVKMN-YNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNI 155
Query: 430 ISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLS 489
IS + +SSF R K L+LS
Sbjct: 156 ISEI---------KTSSFPR-------------------------------MQLKYLNLS 175
Query: 490 LNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASA 549
N I + F+NL + L + N N + + +PH+++L+L NR+
Sbjct: 176 NNRITTLEAGCFDNLSS-SLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLT 234
Query: 550 LTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKS 609
L L L + N I+ + F N N++ L L HNN+ + + +
Sbjct: 235 FQGLDSLRSLKMQRNG----ISKLKDGAFFGLN--NMEELELEHNNLTRVNKGWLYGLRM 288
Query: 610 LVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTEL 669
L +L S N ++ + D ++ + L+ LDLS N+L + AF+ L + L L
Sbjct: 289 LQQLYVSQNAIERISPD-------AWEFCQRLSELDLSYNQLTRLDESAFVGL-SLLERL 340
Query: 670 HINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDF---TSSLRTLLLSHNRISH 726
++ DN + + + L+ LDLR N++ + + S+ +SL L+L N+I
Sbjct: 341 NLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKS 400
Query: 727 LPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRW 786
+ + SL+HLDL++N + +I ++A + T L L L+ + C C + +W
Sbjct: 401 ITKKAFIGLESLEHLDLNNNAIMSIQENAF---SQTHLKELILNTSSLLCDCHLKWLLQW 457
Query: 787 MDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSD 825
+ ++ V+V CA P G+SI++++L V D
Sbjct: 458 LVDN---NFQHSVNVSCAHPEWLAGQSILNVDLKDFVCD 493
Score = 73.9 bits (180), Expect = 7e-13
Identities = 70/251 (27%), Positives = 111/251 (44%), Gaps = 46/251 (18%)
Query: 36 CDEKKQNDSVIAECSNRRLQEVPQTVGK--YVTELDLSDNFITHITNESFQGLQNLTKIN 93
C + + ++ + + R+ +P + K ++ L+L N I + +FQGL +L +
Sbjct: 186 CFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGLTFQGLDSLRSLK 245
Query: 94 LNHNPNVQHQNGNPGIQSNGLN-ITDGAFLNLKNLRELLLEDNQLPQIPSGLP---ESLT 149
+ Q NG++ + DGAF L N+ EL LE N L ++ G L
Sbjct: 246 M---------------QRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQ 290
Query: 150 ELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEK------------------TN 191
+L + QN I I+ + L L L++N ++ E T+
Sbjct: 291 QLYVSQNAIERISPDAWEFCQRLSELDLSYN-QLTRLDESAFVGLSLLERLNLGDNRVTH 349
Query: 192 IEDGVFETLTNLELLSLSFNSLSHVPPKLP------SSLRKLFLSNTQIKYISEEDFKGL 245
I DGVF L+NL+ L L N +S +SL KL L QIK I+++ F GL
Sbjct: 350 IADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGL 409
Query: 246 INLTLLDLSGN 256
+L LDL+ N
Sbjct: 410 ESLEHLDLNNN 420
Score = 67.0 bits (162), Expect = 9e-11
Identities = 89/351 (25%), Positives = 144/351 (41%), Gaps = 73/351 (20%)
Query: 122 LNLKNLRELLLEDNQLPQIPS-GLPES-LTELSLIQNNIYNITKEGISRLINLKNLYLAW 179
L + L+E+ + N+L +IP G P S +T LSL+ N I I + + L++L L+
Sbjct: 94 LESQTLQEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSS 153
Query: 180 NC---------------YFNKVCEK-TNIEDGVFETLTN-LELLSLSFNSLSHVPPKLPS 222
N Y N + T +E G F+ L++ L ++ L+ N +S +PPK+
Sbjct: 154 NIISEIKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK 213
Query: 223 --SLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDR 280
L+ L L +IK + F+GL +L L + N G S +
Sbjct: 214 LPHLQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRN----------------GIS-KLKD 256
Query: 281 FAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLE 340
AF L + L L +L ++N W + L+ L + N + E S RL
Sbjct: 257 GAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNAI--ERISPDAWEFCQRLS 314
Query: 341 ILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTIN 400
LDLS+N +L D + L L +N
Sbjct: 315 ELDLSYN---------------------------------QLTRLDESAFVGLSLLERLN 341
Query: 401 LGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHI 451
LG N + I +F+ SNL+ + L N IS ++D +++A +S + I
Sbjct: 342 LGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLI 392
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 103 bits (256), Expect = 1e-21
Identities = 130/524 (24%), Positives = 212/524 (40%), Gaps = 107/524 (20%)
Query: 48 ECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNP 107
+CS+ L E+P + + + LDLS N I+ + L+ L ++ L N
Sbjct: 51 DCSDLGLSELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTY------ 104
Query: 108 GIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPE---SLTELSLIQNNIYNITKE 164
I GAF L +L+ L+L++NQL +P+ + SL L L N+I +
Sbjct: 105 --------IPKGAFTGLYSLKVLMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPS 156
Query: 165 GISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKL---P 221
S L +L++L+L N T I F +L+ L+ ++L+ N + H+P
Sbjct: 157 CFSGLHSLRHLWLDDNAL-------TEIPVQAFRSLSALQAMTLALNKIHHIPDYAFGNL 209
Query: 222 SSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRF 281
SSL L L N +I + ++ F GL +L LDL+ N N+D F
Sbjct: 210 SSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYN--------------------NLDEF 249
Query: 282 --AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRL 339
A + L+ L+ L S ++R I F P L + N + + + LP L
Sbjct: 250 PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPI--QFVGRSAFQHLPEL 307
Query: 340 EILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTI 399
L L+ +P + + +L +L L G L + QLPNL +
Sbjct: 308 RTLTLNGASQITEFP-------DLTGTANLESLTLTGAQISSLPQ---TVCNQLPNLQVL 357
Query: 400 NLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDF 459
+L N ++ D F L+ I L N I + DT FQ+ + R
Sbjct: 358 DLSYNLLE--DLPSFSVCQKLQKIDLRHNEIYEIKVDT---------FQQLLSLR----- 401
Query: 460 EFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQ 519
+L+L+ N I I PN F LP + L+LS+N
Sbjct: 402 -------------------------SLNLAWNKIAIIHPNAFSTLPSLIKLDLSSN---- 432
Query: 520 VLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSY 563
+LS + + + +L LT N + + +L+V+++ Y
Sbjct: 433 LLSSFPITGLHGLTHLKLTGNHA-LQSLISSENFPELKVIEMPY 475
Score = 86.7 bits (213), Expect = 1e-16
Identities = 87/322 (27%), Positives = 145/322 (45%), Gaps = 43/322 (13%)
Query: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 545
LDLS+N+I + PN +L + L L+ N+ + G F+ + +K L L NN+L
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGA-FTGLYSLKVLMLQNNQLRHV 129
Query: 546 NASALTELSDLEVLDLSYN-------SHYFRIAGVTH-----------HLEFIQNFTNLK 587
AL L L+ L L N S + + + H ++ ++ + L+
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 588 VLNLSHNNIYTLTDKYNLESKSLVELVFSGNR-----------------LDILWNDDDNR 630
+ L+ N I+ + D SLV L NR LD+ +N+ D
Sbjct: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLD-E 248
Query: 631 YISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRL 690
+ + + L NL L N ++ IP +AF+ P SL +H DN ++F + Q P L
Sbjct: 249 FPTAIRTLSNLKELGFHSNNIRSIPEKAFVGNP-SLITIHFYDNPIQFVGRSAFQHLPEL 307
Query: 691 ELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKT 750
L L G + L+ T++L +L L+ +IS LP +++ +L+ LDLS NLL+
Sbjct: 308 RTLTLNGASQITEFPDLTG-TANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLED 366
Query: 751 INKSALETKTTTKLSMLELHGN 772
+ ++ KL ++L N
Sbjct: 367 LPSFSV----CQKLQKIDLRHN 384
Score = 72.8 bits (177), Expect = 2e-12
Identities = 99/420 (23%), Positives = 172/420 (40%), Gaps = 95/420 (22%)
Query: 363 FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEI 422
F+ L SL+ L L+ +LR + L L +L ++ L N I + F +L
Sbjct: 110 FTGLYSLKVLMLQN---NQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRH 166
Query: 423 IYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAY 482
++L +N ++ + Q++ + S+ Q
Sbjct: 167 LWLDDNALTEIPV---QAFRSLSALQ---------------------------------- 189
Query: 483 GKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRL 542
A+ L+LN I ++PD A NLS+ + L L NNR+
Sbjct: 190 --AMTLALNKI--------HHIPDYAFGNLSS-----------------LVVLHLHNNRI 222
Query: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
L LE LDL+YN+ + I+ +NLK L NNI ++ +K
Sbjct: 223 HSLGKKCFDGLHSLETLDLNYNN-------LDEFPTAIRTLSNLKELGFHSNNIRSIPEK 275
Query: 603 YNLESKSLVELVFSGNRLDILWND-----DDNRYISI-----------FKGLKNLTRLDL 646
+ + SL+ + F N + + + R +++ G NL L L
Sbjct: 276 AFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLTL 335
Query: 647 SLNRLKHIPNEAFLNLPASLTELHINDNMLKFF-NWTLLQQFPRLELLDLRGNKLLFLTD 705
+ ++ +P LP +L L ++ N+L+ ++++ Q +L+ +DLR N++ +
Sbjct: 336 TGAQISSLPQTVCNQLP-NLQVLDLSYNLLEDLPSFSVCQ---KLQKIDLRHNEIYEIKV 391
Query: 706 SLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLS 765
SLR+L L+ N+I+ + S + SL LDLSSNLL + + L T KL+
Sbjct: 392 DTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPITGLHGLTHLKLT 451
Score = 55.5 bits (132), Expect = 3e-07
Identities = 73/293 (24%), Positives = 125/293 (42%), Gaps = 42/293 (14%)
Query: 68 LDLSDNFITHITNESFQGLQNLTKINLNHN-----PNVQHQNGNP---GIQSNGL-NITD 118
L L +N I + + F GL +L ++LN+N P N G SN + +I +
Sbjct: 215 LHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIRTLSNLKELGFHSNNIRSIPE 274
Query: 119 GAFLNLKNLRELLLEDNQLPQIPSGLPESLTEL-SLIQNNIYNITK-EGISRLINLKNLY 176
AF+ +L + DN + + + L EL +L N IT+ ++ NL++L
Sbjct: 275 KAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTLNGASQITEFPDLTGTANLESLT 334
Query: 177 LAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPP-KLPSSLRKLFLSNTQIK 235
L + +++ V L NL++L LS+N L +P + L+K+ L + +I
Sbjct: 335 LTG-------AQISSLPQTVCNQLPNLQVLDLSYNLLEDLPSFSVCQKLQKIDLRHNEIY 387
Query: 236 YISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLS 295
I + F+ L++L L+L+ N I AF L L L+LS
Sbjct: 388 EIKVDTFQQLLSLRSLNLAWN-----------------KIAIIHPNAFSTLPSLIKLDLS 430
Query: 296 STSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNY 348
S L + HLK L N+ + + S P L+++++ + Y
Sbjct: 431 SNLLSSFPITGLHGLTHLK---LTGNHALQSLISS---ENFPELKVIEMPYAY 477
Score = 36.6 bits (83), Expect = 0.13
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 8/110 (7%)
Query: 693 LDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTIN 752
LDL N + L + L L L+ N ++++P G + + SLK L L +N L+ +
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 753 KSALETKTTTKLSMLELHGN-----PFECTCDIGDFRR-WMDEHLNVKIP 796
AL+ L L L N P C + R W+D++ +IP
Sbjct: 131 TEALQ--NLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIP 178
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 102 bits (253), Expect = 2e-21
Identities = 88/346 (25%), Positives = 158/346 (45%), Gaps = 25/346 (7%)
Query: 484 KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLD 543
K L L+ N + + P F+NL + L L N N + +P +++L+L N++
Sbjct: 170 KYLYLNSNRVTSMEPGYFDNLAN-TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIK 228
Query: 544 FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLE-FIQNFTNLKVLNLSHNNIYTLTDK 602
+ L L+ L + N GVT ++ +N+++L L HNN+ +T
Sbjct: 229 NVDGLTFQGLGALKSLKMQRN-------GVTKLMDGAFWGLSNMEILQLDHNNLTEITKG 281
Query: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
+ L EL S N ++ + D ++ + L+ LDL+ N L + + +FL L
Sbjct: 282 WLYGLLMLQELHLSQNAINRISPD-------AWEFCQKLSELDLTFNHLSRLDDSSFLGL 334
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSL---RTLLL 719
+ L LHI +N + + + L+ LDL+ N++ + + ++ S L R L+L
Sbjct: 335 -SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLIL 393
Query: 720 SHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCD 779
NRI + + + +L+HLDLS N + ++ +A KL L L+ + C C
Sbjct: 394 QGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF--SQMKKLQQLHLNTSSLLCDCQ 451
Query: 780 IGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSD 825
+ +W+ E+ V+ CA P +G+SI ++ V D
Sbjct: 452 LKWLPQWVAEN---NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCD 494
Score = 96.3 bits (238), Expect = 1e-19
Identities = 127/504 (25%), Positives = 203/504 (40%), Gaps = 96/504 (19%)
Query: 20 GSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHIT 79
G EL + PC + + +CS +RL +P+ + +V LDLS N ++ I
Sbjct: 31 GRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIK 90
Query: 80 NESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQ 139
S LQ+L ++ LN+N P + NIT L+L R + + L +
Sbjct: 91 ASSMSHLQSLREVKLNNN----ELETIPNLGPVSANIT---LLSLAGNRIVEILPEHLKE 143
Query: 140 IPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFET 199
+SL L L NNI + + + LK LYL N T++E G F+
Sbjct: 144 F-----QSLETLDLSSNNISEL--QTAFPALQLKYLYLNSN-------RVTSMEPGYFDN 189
Query: 200 LTN-LELLSLSFNSLSHVPPKL--PSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGN 256
L N L +L L+ N +S +PPK+ L+ L L+ +IK + F+GL L L + N
Sbjct: 190 LANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRN 249
Query: 257 CPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVL 316
G + +D AF L+ + L L +L +I W + L+ L
Sbjct: 250 ----------------GVTKLMDG-AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQEL 292
Query: 317 DLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRG 376
L N + I+ A+ +L LDL+FN++
Sbjct: 293 HLSQN-AINRISPDAW-EFCQKLSELDLTFNHLS-------------------------- 324
Query: 377 YVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKD 436
R DD + L L+T+++G N + I F+ S+L+ + L N IS ++D
Sbjct: 325 ------RLDD-SSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIED 377
Query: 437 TRQSYANSSSFQRHI----RKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNS 492
+++ +R I R R T F H LDLS N+
Sbjct: 378 MNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEH----------------LDLSDNA 421
Query: 493 IFFIGPNQFENLPDIACLNLSANS 516
I + N F + + L+L+ +S
Sbjct: 422 IMSLQGNAFSQMKKLQQLHLNTSS 445
Score = 75.5 bits (184), Expect = 2e-13
Identities = 110/479 (22%), Positives = 181/479 (37%), Gaps = 94/479 (19%)
Query: 204 ELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNA 263
+LL S L+ +P LPS + +L LS+ ++ +I L +L + L+ N
Sbjct: 56 DLLDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNN------- 108
Query: 264 PFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL 323
+P G S NI L+L+ + +I K L+ LDL N +
Sbjct: 109 ELETIPNLGPVSANIT-----------LLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI 157
Query: 324 VGEIASGAFLTMLPRLEI--LDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQE 381
T P L++ L L+ N + P + + N +L L +
Sbjct: 158 ------SELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIP--- 208
Query: 382 LREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSY 441
+ +LP L + L N IK +D FQ L+ + + N ++ L+
Sbjct: 209 ------PKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGL 262
Query: 442 ANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYG----KALDLSLNSIFFIG 497
+N Q H+N T+ + YG + L LS N+I I
Sbjct: 263 SNMEILQL-------------DHNNLTEITKGWL------YGLLMLQELHLSQNAINRIS 303
Query: 498 PNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLE 557
P+ +E ++ L+L+ N ++ L + F + + L + NNR+ + A LS L+
Sbjct: 304 PDAWEFCQKLSELDLTFNHLSR-LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLK 362
Query: 558 VLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSG 617
LDL N + I + N ++ DK L L+ G
Sbjct: 363 TLDLKNNEISWTIEDM--------------------NGAFSGLDK-------LRRLILQG 395
Query: 618 NRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNML 676
NR+ + F GL L LDLS N + + AF + L +LH+N + L
Sbjct: 396 NRIRSITK-------KAFTGLDALEHLDLSDNAIMSLQGNAFSQM-KKLQQLHLNTSSL 446
Score = 73.2 bits (178), Expect = 1e-12
Identities = 78/261 (29%), Positives = 117/261 (44%), Gaps = 35/261 (13%)
Query: 532 VKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNF----TNLK 587
V LDL++NRL F AS+++ L L + L+ N LE I N N+
Sbjct: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNN-----------ELETIPNLGPVSANIT 124
Query: 588 VLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWND-----------DDNRYISI-- 634
+L+L+ N I + ++ E +SL L S N + L + NR S+
Sbjct: 125 LLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEP 184
Query: 635 --FKGLKN-LTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLE 691
F L N L L L+ NR+ IP + F LP L L +N N +K + Q L+
Sbjct: 185 GYFDNLANTLLVLKLNRNRISAIPPKMF-KLP-QLQHLELNRNKIKNVDGLTFQGLGALK 242
Query: 692 LLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTI 751
L ++ N + L D S++ L L HN ++ + G+L + L+ L LS N + I
Sbjct: 243 SLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRI 302
Query: 752 NKSALETKTTTKLSMLELHGN 772
+ A E KLS L+L N
Sbjct: 303 SPDAWE--FCQKLSELDLTFN 321
Score = 63.9 bits (154), Expect = 7e-10
Identities = 92/321 (28%), Positives = 126/321 (39%), Gaps = 37/321 (11%)
Query: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 545
LDLS N + FI + +L + + L+ N + + SA ++ L L NR+
Sbjct: 79 LDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSA--NITLLSLAGNRIVEI 136
Query: 546 NASALTELSDLEVLDLSYNSH---------------YFRIAGVTH-HLEFIQNFTN-LKV 588
L E LE LDLS N+ Y VT + N N L V
Sbjct: 137 LPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLV 196
Query: 589 LNLSHNNIYTLTDKY-------NLES-----KSLVELVFSG----NRLDILWNDDDNRYI 632
L L+ N I + K +LE K++ L F G L + N
Sbjct: 197 LKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 256
Query: 633 SIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLEL 692
F GL N+ L L N L I L L ELH++ N + + + +L
Sbjct: 257 GAFWGLSNMEILQLDHNNLTEITKGWLYGL-LMLQELHLSQNAINRISPDAWEFCQKLSE 315
Query: 693 LDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLK-TI 751
LDL N L L DS S L TL + +NR+S++ +SSLK LDL +N + TI
Sbjct: 316 LDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTI 375
Query: 752 NKSALETKTTTKLSMLELHGN 772
KL L L GN
Sbjct: 376 EDMNGAFSGLDKLRRLILQGN 396
Score = 44.3 bits (103), Expect = 6e-04
Identities = 40/130 (30%), Positives = 61/130 (46%), Gaps = 11/130 (8%)
Query: 644 LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFL 703
LD S RL +P LP+ + L ++ N L F + + L + L N+L +
Sbjct: 58 LDCSRKRLARLPEP----LPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI 113
Query: 704 TDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETK-TTT 762
+L ++++ L L+ NRI + L E SL+ LDLSSN N S L+T
Sbjct: 114 -PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSN-----NISELQTAFPAL 167
Query: 763 KLSMLELHGN 772
+L L L+ N
Sbjct: 168 QLKYLYLNSN 177
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 102 bits (253), Expect = 2e-21
Identities = 88/346 (25%), Positives = 158/346 (45%), Gaps = 25/346 (7%)
Query: 484 KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLD 543
K L L+ N + + P F+NL + L L N N + +P +++L+L N++
Sbjct: 110 KYLYLNSNRVTSMEPGYFDNLAN-TLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIK 168
Query: 544 FDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLE-FIQNFTNLKVLNLSHNNIYTLTDK 602
+ L L+ L + N GVT ++ +N+++L L HNN+ +T
Sbjct: 169 NVDGLTFQGLGALKSLKMQRN-------GVTKLMDGAFWGLSNMEILQLDHNNLTEITKG 221
Query: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
+ L EL S N ++ + D ++ + L+ LDL+ N L + + +FL L
Sbjct: 222 WLYGLLMLQELHLSQNAINRISPD-------AWEFCQKLSELDLTFNHLSRLDDSSFLGL 274
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSL---RTLLL 719
+ L LHI +N + + + L+ LDL+ N++ + + ++ S L R L+L
Sbjct: 275 -SLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLIL 333
Query: 720 SHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGNPFECTCD 779
NRI + + + +L+HLDLS N + ++ +A KL L L+ + C C
Sbjct: 334 QGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAF--SQMKKLQQLHLNTSSLLCDCQ 391
Query: 780 IGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVSD 825
+ +W+ E+ V+ CA P +G+SI ++ V D
Sbjct: 392 LKWLPQWVAEN---NFQSFVNASCAHPQLLKGRSIFAVSPDGFVCD 434
Score = 79.0 bits (193), Expect = 2e-14
Identities = 115/460 (25%), Positives = 185/460 (40%), Gaps = 96/460 (20%)
Query: 64 YVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLN 123
+++ DLS N ++ I S LQ+L ++ LN+N P + NIT L+
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNN----ELETIPNLGPVSANIT---LLS 67
Query: 124 LKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYF 183
L R + + L + +SL L L NNI + + + LK LYL N
Sbjct: 68 LAGNRIVEILPEHLKEF-----QSLETLDLSSNNISEL--QTAFPALQLKYLYLNSN--- 117
Query: 184 NKVCEKTNIEDGVFETLTN-LELLSLSFNSLSHVPPKL--PSSLRKLFLSNTQIKYISEE 240
T++E G F+ L N L +L L+ N +S +PPK+ L+ L L+ +IK +
Sbjct: 118 ----RVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGL 173
Query: 241 DFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLR 300
F+GL L L + N G + +D AF L+ + L L +L
Sbjct: 174 TFQGLGALKSLKMQRN----------------GVTKLMDG-AFWGLSNMEILQLDHNNLT 216
Query: 301 KINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINIS 360
+I W + L+ L L N + I+ A+ +L LDL+FN++
Sbjct: 217 EITKGWLYGLLMLQELHLSQN-AINRISPDAW-EFCQKLSELDLTFNHLS---------- 264
Query: 361 RNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNL 420
R DD + L L+T+++G N + I F+ S+L
Sbjct: 265 ----------------------RLDD-SSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSL 301
Query: 421 EIIYLSENRISPLVKDTRQSYANSSSFQRHI----RKRRSTDFEFDPHSNFYHFTRPLIK 476
+ + L N IS ++D +++ +R I R R T F H
Sbjct: 302 KTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEH------- 354
Query: 477 PQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANS 516
LDLS N+I + N F + + L+L+ +S
Sbjct: 355 ---------LDLSDNAIMSLQGNAFSQMKKLQQLHLNTSS 385
Score = 73.6 bits (179), Expect = 9e-13
Identities = 77/262 (29%), Positives = 117/262 (44%), Gaps = 35/262 (13%)
Query: 531 HVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNF----TNL 586
H+ DL++NRL F AS+++ L L + L+ N LE I N N+
Sbjct: 15 HISRPDLSHNRLSFIKASSMSHLQSLREVKLNNN-----------ELETIPNLGPVSANI 63
Query: 587 KVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWND-----------DDNRYISI- 634
+L+L+ N I + ++ E +SL L S N + L + NR S+
Sbjct: 64 TLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSME 123
Query: 635 ---FKGLKN-LTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRL 690
F L N L L L+ NR+ IP + F LP L L +N N +K + Q L
Sbjct: 124 PGYFDNLANTLLVLKLNRNRISAIPPKMF-KLP-QLQHLELNRNKIKNVDGLTFQGLGAL 181
Query: 691 ELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKT 750
+ L ++ N + L D S++ L L HN ++ + G+L + L+ L LS N +
Sbjct: 182 KSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINR 241
Query: 751 INKSALETKTTTKLSMLELHGN 772
I+ A E KLS L+L N
Sbjct: 242 ISPDAWE--FCQKLSELDLTFN 261
Score = 63.9 bits (154), Expect = 7e-10
Identities = 100/354 (28%), Positives = 149/354 (42%), Gaps = 44/354 (12%)
Query: 425 LSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGK 484
LS NR+S +K A+S S + +R+ + + E + T P + P A
Sbjct: 21 LSHNRLS-FIK------ASSMSHLQSLREVKLNNNELE--------TIPNLGPVSANI-T 64
Query: 485 ALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF 544
L L+ N I I P + + L+LS+N+ +++ T F A+ +KYL L +NR+
Sbjct: 65 LLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ--TAFPAL-QLKYLYLNSNRVTS 121
Query: 545 DNASALTELSD-LEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKY 603
L++ L VL L+ N RI+ + + L+ L L+ N I
Sbjct: 122 MEPGYFDNLANTLLVLKLNRN----RISAIPPKMF---KLPQLQHLELNRNKI------- 167
Query: 604 NLESKSLVELVFSG----NRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAF 659
K++ L F G L + N F GL N+ L L N L I
Sbjct: 168 ----KNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWL 223
Query: 660 LNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLL 719
L L ELH++ N + + + +L LDL N L L DS S L TL +
Sbjct: 224 YGL-LMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHI 282
Query: 720 SHNRISHLPSGFLSEVSSLKHLDLSSNLLK-TINKSALETKTTTKLSMLELHGN 772
+NR+S++ +SSLK LDL +N + TI KL L L GN
Sbjct: 283 GNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGN 336
Score = 62.0 bits (149), Expect = 3e-09
Identities = 101/454 (22%), Positives = 167/454 (36%), Gaps = 94/454 (20%)
Query: 229 LSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQ 288
LS+ ++ +I L +L + L+ N +P G S NI
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNN-------ELETIPNLGPVSANIT--------- 64
Query: 289 LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEI--LDLSF 346
L+L+ + +I K L+ LDL N + T P L++ L L+
Sbjct: 65 --LLSLAGNRIVEILPEHLKEFQSLETLDLSSNNI------SELQTAFPALQLKYLYLNS 116
Query: 347 NYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFI 406
N + P + + N +L L + + +LP L + L N I
Sbjct: 117 NRVTSMEPGYFDNLANTLLVLKLNRNRISAIP---------PKMFKLPQLQHLELNRNKI 167
Query: 407 KQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSN 466
K +D FQ L+ + + N ++ L+ +N Q H+N
Sbjct: 168 KNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQL-------------DHNN 214
Query: 467 FYHFTRPLIKPQCAAYG----KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLS 522
T+ + YG + L LS N+I I P+ +E ++ L+L+ N ++ L
Sbjct: 215 LTEITKGWL------YGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR-LD 267
Query: 523 GTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQN 582
+ F + + L + NNR+ + A LS L+ LDL N + I +
Sbjct: 268 DSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDM--------- 318
Query: 583 FTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLT 642
N ++ DK L L+ GNR+ + F GL L
Sbjct: 319 -----------NGAFSGLDK-------LRRLILQGNRIRSITK-------KAFTGLDALE 353
Query: 643 RLDLSLNRLKHIPNEAFLNLPASLTELHINDNML 676
LDLS N + + AF + L +LH+N + L
Sbjct: 354 HLDLSDNAIMSLQGNAFSQM-KKLQQLHLNTSSL 386
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 102 bits (253), Expect = 2e-21
Identities = 143/544 (26%), Positives = 225/544 (41%), Gaps = 91/544 (16%)
Query: 46 IAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNG 105
+ +C L+E P + ++ L L +N + I E L L +NL +N
Sbjct: 127 VVDCGGIDLREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNR------- 179
Query: 106 NPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEG 165
+ S GL + AF +L NL L L +N+L P LP +L + N + I
Sbjct: 180 ---LTSRGL--PEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLT 234
Query: 166 ISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLR 225
+ NL+++YL + NK+ + + D +F +N+E+L LS N L HVP LP +L
Sbjct: 235 FGQKPNLRSVYL----HNNKLAD-AGLPDNMFNGSSNVEVLILSSNFLRHVPKHLPPALY 289
Query: 226 KLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQN 285
KL L N +++ I F L +L L L N D G +D F
Sbjct: 290 KLHLKNNKLEKIPPGAFSELSSLRELYLQNN-----------YLTDEG----LDNETFWK 334
Query: 286 LTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLS 345
L+ L YL+LSS +L ++ A ++ L +L LE N + A+ LT + LE L L
Sbjct: 335 LSSLEYLDLSSNNLSRVPAGLPRS---LVLLHLEKNAIRSVDAN--VLTPIRSLEYLLLH 389
Query: 346 FNYIK--GSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGI 403
N ++ G +P F L L +HL + + P + T+ +
Sbjct: 390 SNQLREQGIHP------LAFQGLKRLHTVHLYNNALERV------PSGLPRRVRTLMILH 437
Query: 404 NFIKQIDFKLFQNFSNLEIIYLSENRI-SPLVKDTRQSYANSSSFQRHIRKRRSTDFEFD 462
N I I + F LE + LS NRI SP V R ++ R +R RS D
Sbjct: 438 NQITGIGREDFATTYFLEELNLSYNRITSPQVH--RDAF-------RKLRLLRSLDLS-- 486
Query: 463 PHSNFYHFTRP------------------LIKPQCAAYGKALDLSLNSIFF----IGPNQ 500
N H P L + + +L L S +GP
Sbjct: 487 --GNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRA 544
Query: 501 FENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLD 560
+ +L + L+++ N ++ G S ++YL L NN++ A+A +L+ +
Sbjct: 545 WVDLAHLQLLDIAGNQLTEIPEGLPES----LEYLYLQNNKISAVPANAFDSTPNLKGIF 600
Query: 561 LSYN 564
L +N
Sbjct: 601 LRFN 604
Score = 80.1 bits (196), Expect = 1e-14
Identities = 90/345 (26%), Positives = 146/345 (42%), Gaps = 32/345 (9%)
Query: 15 FLLISGSCELCAEENFSRSYPCDEK---KQNDSVIAECSNRRLQEVPQTVGKYVTELDLS 71
F +S EL + N+ D + K + + S+ L VP + + + L L
Sbjct: 306 FSELSSLRELYLQNNYLTDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLHLE 365
Query: 72 DNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELL 131
N I + +++L + L H+ ++ Q +P AF LK L +
Sbjct: 366 KNAIRSVDANVLTPIRSLEYLLL-HSNQLREQGIHPL-----------AFQGLKRLHTVH 413
Query: 132 LEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTN 191
L +N L ++PSGLP + L ++ N I I +E + L+ L L++N +
Sbjct: 414 LYNNALERVPSGLPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSP-----Q 468
Query: 192 IEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLL 251
+ F L L L LS N L +PP LP ++ L + ++ ++ G+ L L
Sbjct: 469 VHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNVHVLKVKRNELAALARGALVGMAQLREL 528
Query: 252 DLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQ--------LRYLNLSSTSLRKIN 303
L+ N R A P D A + + A LT+ L YL L + + +
Sbjct: 529 YLTSNRLRS-RALGPRAWVDL-AHLQLLDIAGNQLTEIPEGLPESLEYLYLQNNKISAVP 586
Query: 304 AAWFKNMPHLKVLDLEFNYL-VGEIASGAFLTMLPRLEILDLSFN 347
A F + P+LK + L FN L VG + AF L L++LD+ N
Sbjct: 587 ANAFDSTPNLKGIFLRFNKLAVGSVVDSAF-RRLKHLQVLDIEGN 630
Score = 71.6 bits (174), Expect = 4e-12
Identities = 138/590 (23%), Positives = 219/590 (37%), Gaps = 124/590 (21%)
Query: 213 LSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDG 272
L P LP L L N Q++ I E+ L L L+L N
Sbjct: 135 LREFPGDLPEHTNHLSLQNNQLEKIYPEELSRLHRLETLNLQNNRL-------------- 180
Query: 273 GASINIDRFAFQNLTQLRYLNLSSTSLR---------------------KINAAWFKNMP 311
S + AF++LT L YL L++ L KI F P
Sbjct: 181 -TSRGLPEKAFEHLTNLNYLYLANNKLTLAPRFLPNALISVDFAANYLTKIYGLTFGQKP 239
Query: 312 HLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRA 371
+L+ + L N L +E+L LS N+++ P+H+ + L
Sbjct: 240 NLRSVYLHNNKLADAGLPDNMFNGSSNVEVLILSSNFLR-HVPKHLPPA--------LYK 290
Query: 372 LHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQ--IDFKLFQNFSNLEIIYLSENR 429
LHL+ +++ F L L L N N++ +D + F S+LE + LS N
Sbjct: 291 LHLKNNKLEKIPPGAFSELSSLRELYLQN---NYLTDEGLDNETFWKLSSLEYLDLSSNN 347
Query: 430 ISPLVKDTRQSYANSSSFQRHIRKR--RSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALD 487
+S + +S H+ K RS D +N R L + L
Sbjct: 348 LSRVPAGLPRSLV-----LLHLEKNAIRSVD------ANVLTPIRSL---------EYLL 387
Query: 488 LSLNSIFFIG--PNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 545
L N + G P F+ L + ++L N+ +V SG V+ L + +N++
Sbjct: 388 LHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLP----RRVRTLMILHNQITGI 443
Query: 546 NASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNL 605
LE L+LSYN RI H + + L+ L+LS N ++TL
Sbjct: 444 GREDFATTYFLEELNLSYN----RITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPP---- 495
Query: 606 ESKSLVELVFSGNRLDILWNDDDNRYISIFKGL-KNLTRLDLSLNRLKHIPNEAFLNLPA 664
GL +N+ L + N L + A + + A
Sbjct: 496 -------------------------------GLPRNVHVLKVKRNELAALARGALVGM-A 523
Query: 665 SLTELHINDNMLKF--FNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHN 722
L EL++ N L+ L+LLD+ GN+L + + L + SL L L +N
Sbjct: 524 QLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAGNQLTEIPEGLPE---SLEYLYLQNN 580
Query: 723 RISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 772
+IS +P+ +LK + L N L + + L +L++ GN
Sbjct: 581 KISAVPANAFDSTPNLKGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 100 bits (250), Expect = 5e-21
Identities = 102/366 (27%), Positives = 161/366 (43%), Gaps = 43/366 (11%)
Query: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFD 545
L+++ +S + N F NL + L L+ N + G F + ++ L L N+L
Sbjct: 102 LEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGL-FQHLAALESLHLQGNQLQAL 160
Query: 546 NASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNL 605
L+ L+ L+L+ N +A + E T+L+ L LS+N + L
Sbjct: 161 PRRLFQPLTHLKTLNLAQNL----LAQLPE--ELFHPLTSLQTLKLSNNALSGLPQGVFG 214
Query: 606 ESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPAS 665
+ SL EL N + L +F L L RL L N + H+P F +L +
Sbjct: 215 KLGSLQELFLDSNNISELPPQ-------VFSQLFCLERLWLQRNAITHLPLSIFASL-GN 266
Query: 666 LTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRIS 725
LT L + NML+ L P L L L N+L + + S+LR+L+LS+N I+
Sbjct: 267 LTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAIT 326
Query: 726 HLPSGFLSEVSSLKHLDLSSNLLKTI------NKSALETKTTTK---------------- 763
HLP+G ++ L L L SN L + N S LE + +K
Sbjct: 327 HLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYN 386
Query: 764 LSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDV--ICASPGDQRGKSIVSLELTT 821
L L LHGNP++C C + W+ ++ + RL+++ CA P +G+ + +L
Sbjct: 387 LFNLALHGNPWQCDCHLAYLFNWLQQYTD----RLLNIQTYCAGPAYLKGQVVPALNEKQ 442
Query: 822 CVSDVT 827
V VT
Sbjct: 443 LVCPVT 448
Score = 95.9 bits (237), Expect = 2e-19
Identities = 109/401 (27%), Positives = 166/401 (41%), Gaps = 75/401 (18%)
Query: 49 CSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQ----N 104
CS+ L VP + Y + + T + +F NLTK+ + Q +
Sbjct: 35 CSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFG 94
Query: 105 GNPGIQ------SNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPE---SLTELSLIQ 155
G P ++ S+ LN++ F NL +L +L L N L +P GL + +L L L
Sbjct: 95 GLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQG 154
Query: 156 NNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSH 215
N + + + L +LK L LA N + + +F LT+L+ L LS N+LS
Sbjct: 155 NQLQALPRRLFQPLTHLKTLNLAQNLL-------AQLPEELFHPLTSLQTLKLSNNALSG 207
Query: 216 VPPKL---PSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDG 272
+P + SL++LFL + I + + F L L L L N
Sbjct: 208 LPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN---------------- 251
Query: 273 GASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAF 332
A ++ F +L L +L+L LR + A F + P L L L N L +A G F
Sbjct: 252 -AITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQL-ETVAEGTF 309
Query: 333 LTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQ 392
L L L LS+N I HL +F++L E
Sbjct: 310 -AHLSNLRSLMLSYNAI----------------------THLPAGIFRDLEE-------- 338
Query: 393 LPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPL 433
L + LG N + + LFQN S LE++ LS+N+++ L
Sbjct: 339 ---LVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTL 376
Score = 79.0 bits (193), Expect = 2e-14
Identities = 96/352 (27%), Positives = 154/352 (43%), Gaps = 48/352 (13%)
Query: 285 NLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDL 344
NLT++ +LN T L + F +P L+ L++ + + S + L L L L
Sbjct: 74 NLTKVVFLN---TQLCQFRPDAFGGLPRLEDLEVTGSSFLN--LSTNIFSNLTSLGKLTL 128
Query: 345 SFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGIN 404
+FN ++ + P+ + F L +L +LHL+G Q L FQPL +L T+NL N
Sbjct: 129 NFNMLE-ALPEGL-----FQHLAALESLHLQGNQLQALPRRLFQPLT---HLKTLNLAQN 179
Query: 405 FIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPH 464
+ Q+ +LF ++L+ + LS N +S L + + S Q E
Sbjct: 180 LLAQLPEELFHPLTSLQTLKLSNNALSGLPQGV---FGKLGSLQ-----------ELFLD 225
Query: 465 SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGT 524
SN P + Q + L L N+I + + F +L ++ L+L N +VL
Sbjct: 226 SNNISELPPQVFSQLFCL-ERLWLQRNAITHLPLSIFASLGNLTFLSLQWNM-LRVLPAG 283
Query: 525 EFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLE------ 578
F+ P + L LT+N+L+ LS+L L LSYN+ AG+ LE
Sbjct: 284 LFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLY 343
Query: 579 ------------FIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGN 618
QN + L++L+LS N + TL + + +L L GN
Sbjct: 344 LGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 50.1 bits (118), Expect = 1e-05
Identities = 60/202 (29%), Positives = 89/202 (44%), Gaps = 37/202 (18%)
Query: 50 SNRRLQEVPQTV-GKY--VTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGN 106
SN L +PQ V GK + EL L N I+ + + F L L ++ L N
Sbjct: 201 SNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN--------- 251
Query: 107 PGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGL---PESLTELSLIQNNIYNITK 163
I L+I F +L NL L L+ N L +P+GL L LSL N + + +
Sbjct: 252 -AITHLPLSI----FASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAE 306
Query: 164 EGISRLINLKNLYLAWNCY-------FNKVCEK----------TNIEDGVFETLTNLELL 206
+ L NL++L L++N F + E T + +F+ L+ LELL
Sbjct: 307 GTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELL 366
Query: 207 SLSFNSLSHVPPKLPSSLRKLF 228
SLS N L+ +P + + LF
Sbjct: 367 SLSKNQLTTLPEGIFDTNYNLF 388
Score = 48.9 bits (115), Expect = 2e-05
Identities = 50/177 (28%), Positives = 78/177 (44%), Gaps = 23/177 (12%)
Query: 51 NRRLQEVPQTVGKYVTELD---LSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNG-- 105
+ + E+P V + L+ L N ITH+ F L NLT ++L N G
Sbjct: 226 SNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLF 285
Query: 106 -------NPGIQSNGLN-ITDGAFLNLKNLRELLLEDNQLPQIPSGL---PESLTELSLI 154
+ N L + +G F +L NLR L+L N + +P+G+ E L +L L
Sbjct: 286 AHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLG 345
Query: 155 QNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFN 211
NN+ + L L+ L L+ N + T + +G+F+T NL L+L N
Sbjct: 346 SNNLTALHPALFQNLSKLELLSLSKN-------QLTTLPEGIFDTNYNLFNLALHGN 395
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 99.8 bits (247), Expect = 1e-20
Identities = 147/569 (25%), Positives = 213/569 (37%), Gaps = 137/569 (24%)
Query: 36 CDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLN 95
C D + CS+R L +P V L L N ++ + +FQ L +L +NL
Sbjct: 85 CSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNL- 143
Query: 96 HNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGL---PESLTELS 152
Q G G ++ A L L+NL L LE NQL + G +L L
Sbjct: 144 -------QGGQLG------SLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLG 190
Query: 153 LIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNS 212
L N + + +EDG+FE L +L L+L +NS
Sbjct: 191 LSNNRL-------------------------------SRLEDGLFEGLGSLWDLNLGWNS 219
Query: 213 LSHVPP---KLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVP 269
L+ +P + SLR+L L+ ++ Y+ F GL L LDLS N
Sbjct: 220 LAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRN------------- 266
Query: 270 CDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIAS 329
+LR I A F +P L+ L L+ N L+ +A
Sbjct: 267 ----------------------------ALRAIKANVFVQLPRLQKLYLDRN-LIAAVAP 297
Query: 330 GAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQP 389
GAFL L L LDLS N + G + F LL LR L L LR F+
Sbjct: 298 GAFLG-LKALRWLDLSHNRVAGL------LEDTFPGLLGLRVLRLSHNAIASLRPRTFKD 350
Query: 390 LMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ- 448
L L L LG N I+Q+ + F+ LE++ L N++ + N +
Sbjct: 351 LHFLEEL---QLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNL 407
Query: 449 -------------RHIRKRRSTDFE------FDPH--SNFYHFTRPLIK-------PQCA 480
R + K S E PH + R +K + +
Sbjct: 408 SGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQS 467
Query: 481 AYGKA----LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
+G A LDL+ N + + F+ L + L LS N A+ L + +LD
Sbjct: 468 LWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLD 526
Query: 537 LTNNRLDFDNASALTELSDLEVLDLSYNS 565
+++NRL+ S L L L L L NS
Sbjct: 527 VSHNRLEALPNSLLAPLGRLRYLSLRNNS 555
Score = 97.4 bits (241), Expect = 6e-20
Identities = 133/524 (25%), Positives = 201/524 (38%), Gaps = 94/524 (17%)
Query: 363 FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEI 422
F L SL L+L+G L Q L+ L NL ++L N ++ + F + L
Sbjct: 132 FQNLSSLGFLNLQGGQLGSLEP---QALLGLENLCHLHLERNQLRSLALGTFAHTPALAS 188
Query: 423 IYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAY 482
+ LS NR+S L + + + + P A
Sbjct: 189 LGLSNNRLSRLEDGLFEGLGSLWDLN-------------------LGWNSLAVLPDAAFR 229
Query: 483 G----KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLT 538
G + L L+ N + ++ P F L ++ L+LS N+ + + F +P ++ L L
Sbjct: 230 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVFVQLPRLQKLYLD 288
Query: 539 NNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYT 598
N + A L L LDLS+N R+AG+ + L+VL LSHN I +
Sbjct: 289 RNLIAAVAPGAFLGLKALRWLDLSHN----RVAGLLE--DTFPGLLGLRVLRLSHNAIAS 342
Query: 599 LT-----DKYNLES--------KSLVELVFSG-NRLDILWNDDDNRY---ISIFKGLKNL 641
L D + LE + L E F G +L++L D + F GL N+
Sbjct: 343 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNV 402
Query: 642 TRLDLSLNRLKHIPNEAFLNLP-----------------------ASLTELHINDNMLKF 678
++LS N L+++P + F L + L L + DN L
Sbjct: 403 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 462
Query: 679 FNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSL 738
L L LDL N+L L L L LLLS NR++ LP+ L +
Sbjct: 463 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRA 522
Query: 739 KHLDLSSNLLKTINKSALE------------------TKTTTKLSMLELHGNPFECTCDI 780
LD+S N L+ + S L T L L L GNP++C C +
Sbjct: 523 FWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPL 582
Query: 781 GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVS 824
R + ++ + +PR V IC GD + TC S
Sbjct: 583 KALRDFALQNPSA-VPRFVQAIC--EGDDCQPPAYTYNNITCAS 623
Score = 70.1 bits (170), Expect = 1e-11
Identities = 78/300 (26%), Positives = 118/300 (39%), Gaps = 46/300 (15%)
Query: 68 LDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNL 127
LDLS N + + ++F GL L + L+HN ++ F +L L
Sbjct: 309 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIA--------------SLRPRTFKDLHFL 354
Query: 128 RELLLEDNQLPQIPSGLPESLTELSLI---QNNIYNITKEGISRLINLKNLYLAWNCYFN 184
EL L N++ Q+ E L +L ++ N + + L N+ + L+ NC
Sbjct: 355 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-- 412
Query: 185 KVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKL---PSSLRKLFLSNTQIKYISEED 241
N+ + VF L L L L + L + P S LR+LFL + + I E+
Sbjct: 413 -----RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQS 467
Query: 242 FKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRK 301
GL L LDL+ N ++ FQ L +L YL LS L +
Sbjct: 468 LWGLAELLELDLTSN-----------------QLTHLPHRLFQGLGKLEYLLLSRNRLAE 510
Query: 302 INAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISR 361
+ A + LD+ N L E + L L RL L L N ++ PQ + R
Sbjct: 511 LPADALGPLQRAFWLDVSHNRL--EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 568
Score = 52.8 bits (125), Expect = 2e-06
Identities = 67/248 (27%), Positives = 101/248 (40%), Gaps = 34/248 (13%)
Query: 64 YVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGN---------PGIQSNGL 114
++ EL L N I + SF+GL L + L+HN + + G + N L
Sbjct: 353 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 412
Query: 115 -NITDGAFLNLKNLRELLLEDNQL----PQIPSGLPESLTELSLIQNNIYNITKEGISRL 169
N+ + F L L L LE + L P +GL L L L N + I ++ + L
Sbjct: 413 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL-SGLRRLFLKDNGLVGIEEQSLWGL 471
Query: 170 INLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLF- 228
L L L N + T++ +F+ L LE L LS N L+ +P L++ F
Sbjct: 472 AELLELDLTSN-------QLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 524
Query: 229 --LSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCV--------PCDGGASINI 278
+S+ +++ + L L L L N R F P + P D G +
Sbjct: 525 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 584
Query: 279 DR-FAFQN 285
R FA QN
Sbjct: 585 LRDFALQN 592
Score = 50.1 bits (118), Expect = 1e-05
Identities = 51/158 (32%), Positives = 68/158 (43%), Gaps = 14/158 (8%)
Query: 626 DDDNRYISIFKGLKNLTRLD-----------LSLNRLKHIPNEAFLNLPASLTELHINDN 674
DDD +S+F +NLTRL L N L +P AF NL +SL L++
Sbjct: 88 DDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNL-SSLGFLNLQGG 146
Query: 675 MLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSE 734
L L L L L N+L L T +L +L LS+NR+S L G
Sbjct: 147 QLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEG 206
Query: 735 VSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 772
+ SL L+L N L + +A + L L L GN
Sbjct: 207 LGSLWDLNLGWNSLAVLPDAAF--RGLGSLRELVLAGN 242
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 99.8 bits (247), Expect = 1e-20
Identities = 147/569 (25%), Positives = 213/569 (37%), Gaps = 137/569 (24%)
Query: 36 CDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLN 95
C D + CS+R L +P V L L N ++ + +FQ L +L +NL
Sbjct: 47 CSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNL- 105
Query: 96 HNPNVQHQNGNPGIQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGL---PESLTELS 152
Q G G ++ A L L+NL L LE NQL + G +L L
Sbjct: 106 -------QGGQLG------SLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLG 152
Query: 153 LIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNS 212
L N + + +EDG+FE L +L L+L +NS
Sbjct: 153 LSNNRL-------------------------------SRLEDGLFEGLGSLWDLNLGWNS 181
Query: 213 LSHVPP---KLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVP 269
L+ +P + SLR+L L+ ++ Y+ F GL L LDLS N
Sbjct: 182 LAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRN------------- 228
Query: 270 CDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIAS 329
+LR I A F +P L+ L L+ N L+ +A
Sbjct: 229 ----------------------------ALRAIKANVFVQLPRLQKLYLDRN-LIAAVAP 259
Query: 330 GAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQP 389
GAFL L L LDLS N + G + F LL LR L L LR F+
Sbjct: 260 GAFLG-LKALRWLDLSHNRVAGL------LEDTFPGLLGLRVLRLSHNAIASLRPRTFKD 312
Query: 390 LMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ- 448
L L L LG N I+Q+ + F+ LE++ L N++ + N +
Sbjct: 313 LHFLEEL---QLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNL 369
Query: 449 -------------RHIRKRRSTDFE------FDPH--SNFYHFTRPLIK-------PQCA 480
R + K S E PH + R +K + +
Sbjct: 370 SGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQS 429
Query: 481 AYGKA----LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLD 536
+G A LDL+ N + + F+ L + L LS N A+ L + +LD
Sbjct: 430 LWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLD 488
Query: 537 LTNNRLDFDNASALTELSDLEVLDLSYNS 565
+++NRL+ S L L L L L NS
Sbjct: 489 VSHNRLEALPNSLLAPLGRLRYLSLRNNS 517
Score = 97.4 bits (241), Expect = 6e-20
Identities = 133/524 (25%), Positives = 201/524 (38%), Gaps = 94/524 (17%)
Query: 363 FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEI 422
F L SL L+L+G L Q L+ L NL ++L N ++ + F + L
Sbjct: 94 FQNLSSLGFLNLQGGQLGSLEP---QALLGLENLCHLHLERNQLRSLALGTFAHTPALAS 150
Query: 423 IYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAY 482
+ LS NR+S L + + + + P A
Sbjct: 151 LGLSNNRLSRLEDGLFEGLGSLWDLN-------------------LGWNSLAVLPDAAFR 191
Query: 483 G----KALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLT 538
G + L L+ N + ++ P F L ++ L+LS N+ + + F +P ++ L L
Sbjct: 192 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVFVQLPRLQKLYLD 250
Query: 539 NNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYT 598
N + A L L LDLS+N R+AG+ + L+VL LSHN I +
Sbjct: 251 RNLIAAVAPGAFLGLKALRWLDLSHN----RVAGLLE--DTFPGLLGLRVLRLSHNAIAS 304
Query: 599 LT-----DKYNLES--------KSLVELVFSG-NRLDILWNDDDNRY---ISIFKGLKNL 641
L D + LE + L E F G +L++L D + F GL N+
Sbjct: 305 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNV 364
Query: 642 TRLDLSLNRLKHIPNEAFLNLP-----------------------ASLTELHINDNMLKF 678
++LS N L+++P + F L + L L + DN L
Sbjct: 365 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG 424
Query: 679 FNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSL 738
L L LDL N+L L L L LLLS NR++ LP+ L +
Sbjct: 425 IEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRA 484
Query: 739 KHLDLSSNLLKTINKSALE------------------TKTTTKLSMLELHGNPFECTCDI 780
LD+S N L+ + S L T L L L GNP++C C +
Sbjct: 485 FWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPL 544
Query: 781 GDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCVS 824
R + ++ + +PR V IC GD + TC S
Sbjct: 545 KALRDFALQNPSA-VPRFVQAIC--EGDDCQPPAYTYNNITCAS 585
Score = 70.1 bits (170), Expect = 1e-11
Identities = 78/300 (26%), Positives = 118/300 (39%), Gaps = 46/300 (15%)
Query: 68 LDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPGIQSNGLNITDGAFLNLKNL 127
LDLS N + + ++F GL L + L+HN ++ F +L L
Sbjct: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIA--------------SLRPRTFKDLHFL 316
Query: 128 RELLLEDNQLPQIPSGLPESLTELSLI---QNNIYNITKEGISRLINLKNLYLAWNCYFN 184
EL L N++ Q+ E L +L ++ N + + L N+ + L+ NC
Sbjct: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-- 374
Query: 185 KVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKL---PSSLRKLFLSNTQIKYISEED 241
N+ + VF L L L L + L + P S LR+LFL + + I E+
Sbjct: 375 -----RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQS 429
Query: 242 FKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRK 301
GL L LDL+ N ++ FQ L +L YL LS L +
Sbjct: 430 LWGLAELLELDLTSN-----------------QLTHLPHRLFQGLGKLEYLLLSRNRLAE 472
Query: 302 INAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISR 361
+ A + LD+ N L E + L L RL L L N ++ PQ + R
Sbjct: 473 LPADALGPLQRAFWLDVSHNRL--EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 530
Score = 52.8 bits (125), Expect = 2e-06
Identities = 67/248 (27%), Positives = 101/248 (40%), Gaps = 34/248 (13%)
Query: 64 YVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGN---------PGIQSNGL 114
++ EL L N I + SF+GL L + L+HN + + G + N L
Sbjct: 315 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
Query: 115 -NITDGAFLNLKNLRELLLEDNQL----PQIPSGLPESLTELSLIQNNIYNITKEGISRL 169
N+ + F L L L LE + L P +GL L L L N + I ++ + L
Sbjct: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL-SGLRRLFLKDNGLVGIEEQSLWGL 433
Query: 170 INLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLF- 228
L L L N + T++ +F+ L LE L LS N L+ +P L++ F
Sbjct: 434 AELLELDLTSN-------QLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 486
Query: 229 --LSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCV--------PCDGGASINI 278
+S+ +++ + L L L L N R F P + P D G +
Sbjct: 487 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 546
Query: 279 DR-FAFQN 285
R FA QN
Sbjct: 547 LRDFALQN 554
Score = 50.1 bits (118), Expect = 1e-05
Identities = 51/158 (32%), Positives = 68/158 (43%), Gaps = 14/158 (8%)
Query: 626 DDDNRYISIFKGLKNLTRLD-----------LSLNRLKHIPNEAFLNLPASLTELHINDN 674
DDD +S+F +NLTRL L N L +P AF NL +SL L++
Sbjct: 50 DDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNL-SSLGFLNLQGG 108
Query: 675 MLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSE 734
L L L L L N+L L T +L +L LS+NR+S L G
Sbjct: 109 QLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEG 168
Query: 735 VSSLKHLDLSSNLLKTINKSALETKTTTKLSMLELHGN 772
+ SL L+L N L + +A + L L L GN
Sbjct: 169 LGSLWDLNLGWNSLAVLPDAAF--RGLGSLRELVLAGN 204
>gi|167555127 CD180 molecule [Homo sapiens]
Length = 661
Score = 99.4 bits (246), Expect = 2e-20
Identities = 179/692 (25%), Positives = 286/692 (41%), Gaps = 98/692 (14%)
Query: 187 CEKTNIEDGVFETLTNL-ELLSLSFNSLSHVPPKLPSSLRKLF---LSNTQIKYISEEDF 242
CE + + + +TL N E L SFN L + + S L L L+ QI +I E+ F
Sbjct: 39 CENLGLSE-IPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTF 97
Query: 243 KGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKI 302
+ L+ L L+GN P F A S+N + L++L L T + +
Sbjct: 98 QSHHQLSTLVLTGN-PLIFMAE---------TSLNGPK-------SLKHLFLIQTGISNL 140
Query: 303 NAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLP--RLEILDLSFNYIK-------GSY 353
N+ +L+ L L N+ I+S F P L++LD N I S
Sbjct: 141 EFIPVHNLENLESLYLGSNH----ISSIKFPKDFPARNLKVLDFQNNAIHYISREDMRSL 196
Query: 354 PQHINISRNFSKLLSLRALHLRGY---VFQELREDDFQPLMQLPNLSTINLGINFIKQID 410
Q IN+S NF+ +++ + L + +FQ L PNLS I G+
Sbjct: 197 EQAINLSLNFNGN-NVKGIELGAFDSTIFQSLNFGG------TPNLSVIFNGLQNSTTQS 249
Query: 411 FKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRH-IRKRRSTDFEFDPHSNFYH 469
L F +++ E+ S ++K + S + Q H ST F
Sbjct: 250 LWL-GTFEDID----DEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTF---------- 294
Query: 470 FTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQV--LSGTEFS 527
QC + LDL+ + + P+ + L + L LS N Q+ +S F
Sbjct: 295 --------QCFTQLQELDLTATHLKGL-PSGMKGLNLLKKLVLSVNHFDQLCQISAANFP 345
Query: 528 AIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLK 587
++ H+ Y+ +L L +L +L+ LDLS+N A L+ ++N ++L+
Sbjct: 346 SLTHL-YIRGNVKKLHL-GVGCLEKLGNLQTLDLSHNDIE---ASDCCSLQ-LKNLSHLQ 399
Query: 588 VLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLS 647
LNLSHN L + E L L + RL I N S F+ L L L+L+
Sbjct: 400 TLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHI------NAPQSPFQNLHFLQVLNLT 453
Query: 648 LNRLKHIPNEAFLNLPA----SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFL 703
L LP +L H D + N LLQ LE+L L LL +
Sbjct: 454 YCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTN--LLQTVGSLEVLILSSCGLLSI 511
Query: 704 TDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTINKSALETKTTTK 763
+ + LSHN ++ LS + + +L+L++N + I+ L ++
Sbjct: 512 DQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSINIISPRLLPI--LSQ 568
Query: 764 LSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLELTTCV 823
S + L NP +CTC F W E+L+ K+ + CA+P RG + ++L+
Sbjct: 569 QSTINLSHNPLDCTCSNIHFLTWYKENLH-KLEGSEETTCANPPSLRGVKLSDVKLS--- 624
Query: 824 SDVTAVILFFFTFFITTMVMLAALA-HHLFYW 854
+TA+ +FF F+ + +L A +L W
Sbjct: 625 CGITAIGIFFLIVFLLLLAILLFFAVKYLLRW 656
Score = 80.5 bits (197), Expect = 8e-15
Identities = 157/629 (24%), Positives = 245/629 (38%), Gaps = 131/629 (20%)
Query: 11 LTCIF--LLISGSCELCAEENFSRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTEL 68
++C F +L S C++ S C EK+ N + C N L E+P T+ L
Sbjct: 5 VSCFFWVVLFSAGCKVIT----SWDQMCIEKEANKTY--NCENLGLSEIPDTLPNTTEFL 58
Query: 69 DLSDNFITHITNESFQGLQNLT-------KINLNHNPNVQ--HQ------NGNPGI---- 109
+ S NF+ I N +F L NLT +IN H Q HQ GNP I
Sbjct: 59 EFSFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAE 118
Query: 110 -QSNGLNITDGAFL--------------NLKNLRELLLEDNQLPQI--PSGLP-ESLTEL 151
NG FL NL+NL L L N + I P P +L L
Sbjct: 119 TSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVL 178
Query: 152 SLIQNNIYNITKEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLT--NLELLSLS 209
N I+ I++E + L NL L +N K E + +F++L LS+
Sbjct: 179 DFQNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVI 238
Query: 210 FNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVP 269
FN L + S+ + L+L + I +ED + L ++S F
Sbjct: 239 FNGLQN------STTQSLWLGT--FEDIDDEDISSAMLKGLCEMSVESLNLQEHRFS--- 287
Query: 270 CDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL--VGEI 327
+I FQ TQL+ L+L++T L+ + + K + LK L L N+ + +I
Sbjct: 288 -------DISSTTFQCFTQLQELDLTATHLKGLPSG-MKGLNLLKKLVLSVNHFDQLCQI 339
Query: 328 ASGAF---------------------LTMLPRLEILDLSFNYIKGSYPQHINISRNFSKL 366
++ F L L L+ LDLS N I+ S + + +N S L
Sbjct: 340 SAANFPSLTHLYIRGNVKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQL-KNLSHL 398
Query: 367 LSLRALH-----LRGYVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLE 421
+L H L+ F+E P ++L +L+ L IN + FQN L+
Sbjct: 399 QTLNLSHNEPLGLQSQAFKEC------PQLELLDLAFTRLHINAPQ----SPFQNLHFLQ 448
Query: 422 IIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKP---- 477
++ N + + Q RH+ + + HF I
Sbjct: 449 VL----NLTYCFLDTSNQHLLAGLPVLRHLNLKGN------------HFQDGTITKTNLL 492
Query: 478 QCAAYGKALDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVK--YL 535
Q + L LS + I F +L ++ ++LS NS L+ ++ H+K YL
Sbjct: 493 QTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNS----LTCDSIDSLSHLKGIYL 548
Query: 536 DLTNNRLDFDNASALTELSDLEVLDLSYN 564
+L N ++ + L LS ++LS+N
Sbjct: 549 NLAANSINIISPRLLPILSQQSTINLSHN 577
>gi|5901992 keratocan [Homo sapiens]
Length = 352
Score = 99.0 bits (245), Expect = 2e-20
Identities = 84/294 (28%), Positives = 135/294 (45%), Gaps = 42/294 (14%)
Query: 49 CSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPG 108
C NR L+E+P + + L L +N I I + F+ L INLN N +
Sbjct: 58 CENRGLKEIP-AIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNY------ 110
Query: 109 IQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISR 168
I GA LK L L LEDN+L ++PS LP SL +L L +N + I + S
Sbjct: 111 ------GIEKGALSQLKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSN 164
Query: 169 LINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNLELLSLSFNSLSHVPPKLPSSLRKLF 228
L NL L L N + ++ F+ L NL L+++ N+L ++PP+LP++ +LF
Sbjct: 165 LENLTLLDLQNNKLVDNAFQR-----DTFKGLKNLMQLNMAKNALRNMPPRLPANTMQLF 219
Query: 229 LSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAFQNLTQ 288
L N I+ I E F + + L L+ N + + P D + +++ + + LT+
Sbjct: 220 LDNNSIEGIPENYFNVIPKVAFLRLNHN--KLSDEGLPSRGFDVSSILDL-QLSHNQLTK 276
Query: 289 -------LRYLNLSSTSLRKINAA--------------WFKNMPHLKVLDLEFN 321
L++L+L ++ +N + F PHL+ L L+ N
Sbjct: 277 VPRISAHLQHLHLDHNKIKSVNVSVICPSPSMLPAERDSFSYGPHLRYLRLDGN 330
Score = 60.8 bits (146), Expect = 6e-09
Identities = 79/276 (28%), Positives = 121/276 (43%), Gaps = 54/276 (19%)
Query: 486 LDLSLNSIFFIGPNQFENLPDIACLNLSANSNAQVLSGTEFSAIPHVK---YLDLTNNRL 542
L L N I I FEN + +NL N N G E A+ +K +L L +N L
Sbjct: 76 LYLQNNLIETIPEKPFENATQLRWINL--NKNKITNYGIEKGALSQLKKLLFLFLEDNEL 133
Query: 543 DFDNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDK 602
+ + S L LE L L+ N RI T N NL +L+L +N
Sbjct: 134 E-EVPSPLPR--SLEQLQLARNK-VSRIPQGT-----FSNLENLTLLDLQNNK------- 177
Query: 603 YNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNL 662
LV+ F + FKGLKNL +L+++ N L+++P L
Sbjct: 178 -------LVDNAFQRDT---------------FKGLKNLMQLNMAKNALRNMPP----RL 211
Query: 663 PASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDF-TSSLRTLLLSH 721
PA+ +L +++N ++ P++ L L NKL F SS+ L LSH
Sbjct: 212 PANTMQLFLDNNSIEGIPENYFNVIPKVAFLRLNHNKLSDEGLPSRGFDVSSILDLQLSH 271
Query: 722 NRISHLPSGFLSEVSS-LKHLDLSSNLLKTINKSAL 756
N+++ +P +S+ L+HL L N +K++N S +
Sbjct: 272 NQLTKVP-----RISAHLQHLHLDHNKIKSVNVSVI 302
Score = 35.8 bits (81), Expect = 0.22
Identities = 35/151 (23%), Positives = 61/151 (40%), Gaps = 20/151 (13%)
Query: 218 PKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASIN 277
P +PS + L+L N I+ I E+ F+ L ++L+ N + + GA
Sbjct: 67 PAIPSRIWYLYLQNNLIETIPEKPFENATQLRWINLNKNKITNYGI-------EKGALSQ 119
Query: 278 IDRFAFQNLTQ-------------LRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLV 324
+ + F L L L L+ + +I F N+ +L +LDL+ N LV
Sbjct: 120 LKKLLFLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLV 179
Query: 325 GEIASGAFLTMLPRLEILDLSFNYIKGSYPQ 355
L L L+++ N ++ P+
Sbjct: 180 DNAFQRDTFKGLKNLMQLNMAKNALRNMPPR 210
Score = 35.0 bits (79), Expect = 0.37
Identities = 62/253 (24%), Positives = 93/253 (36%), Gaps = 65/253 (25%)
Query: 581 QNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDNRYISIFKGLKN 640
+N T L+ +NL+ N I Y +E +L +L K
Sbjct: 92 ENATQLRWINLNKNKI----TNYGIEKGALSQL-------------------------KK 122
Query: 641 LTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKL 700
L L L N L+ +P+ LP SL +L + N + L LLDL+ NKL
Sbjct: 123 LLFLFLEDNELEEVPSP----LPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKL 178
Query: 701 L---FLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSS------NLLKTI 751
+ F D+ +L L ++ N + ++P + L LD +S N I
Sbjct: 179 VDNAFQRDTFKGL-KNLMQLNMAKNALRNMPPRLPANTMQL-FLDNNSIEGIPENYFNVI 236
Query: 752 NKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRL------------- 798
K A KLS L F+ + I D + + + K+PR+
Sbjct: 237 PKVAFLRLNHNKLSDEGLPSRGFDVS-SILDLQ--LSHNQLTKVPRISAHLQHLHLDHNK 293
Query: 799 -----VDVICASP 806
V VIC SP
Sbjct: 294 IKSVNVSVICPSP 306
Score = 35.0 bits (79), Expect = 0.37
Identities = 50/221 (22%), Positives = 83/221 (37%), Gaps = 41/221 (18%)
Query: 377 YVFQELREDDFQPLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKD 436
++F E E + P +L + L N + +I F N NL ++ L N++
Sbjct: 125 FLFLEDNELEEVPSPLPRSLEQLQLARNKVSRIPQGTFSNLENLTLLDLQNNKLV----- 179
Query: 437 TRQSYANSSSFQRHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFI 496
++FQR K + + N + P+ A L L NSI I
Sbjct: 180 -------DNAFQRDTFKGLKNLMQLNMAKNALRN----MPPRLPANTMQLFLDNNSIEGI 228
Query: 497 GPNQFENLPDIACLNLSANSNAQ----------------VLSGTEFSAIP----HVKYLD 536
N F +P +A L L+ N + LS + + +P H+++L
Sbjct: 229 PENYFNVIPKVAFLRLNHNKLSDEGLPSRGFDVSSILDLQLSHNQLTKVPRISAHLQHLH 288
Query: 537 LTNNRLDFDNASAL---TELSDLEVLDLSYNSH--YFRIAG 572
L +N++ N S + + E SY H Y R+ G
Sbjct: 289 LDHNKIKSVNVSVICPSPSMLPAERDSFSYGPHLRYLRLDG 329
>gi|41349454 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 99.0 bits (245), Expect = 2e-20
Identities = 87/299 (29%), Positives = 136/299 (45%), Gaps = 49/299 (16%)
Query: 49 CSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPG 108
C +R L++VP + + L L +NFIT + ESFQ L INL++N
Sbjct: 89 CDSRNLRKVP-VIPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNN----------- 136
Query: 109 IQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISR 168
I L L L +E NQL ++PS LP +L +L L QN+I I S+
Sbjct: 137 ---RIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSK 193
Query: 169 LINLKNLYLAWNCYFNKVCEKTNIEDGVFET-----LTNLELLSLSFNSLSHVPPKLPSS 223
L NL L L N + DGVF+ L NL L+L+ N L +PP++P++
Sbjct: 194 LENLLLLDLQHN----------RLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTA 243
Query: 224 LRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAF 283
+ +L+L + +I+ I FK NL + L+ N P +++
Sbjct: 244 IHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLPKNSFNISNLLVLHLSHNRI 303
Query: 284 QNL----TQLRYLNLSSTSLRKIN---------------AAWFKNMPHLKVLDLEFNYL 323
++ +L +L L++ S+ KIN ++ +N+PHL+ L L+ NYL
Sbjct: 304 SSVPAINNRLEHLYLNNNSIEKINGTQICPNDLVAFHDFSSDLENVPHLRYLRLDGNYL 362
Score = 55.5 bits (132), Expect = 3e-07
Identities = 59/217 (27%), Positives = 99/217 (45%), Gaps = 49/217 (22%)
Query: 577 LEFIQNFTNLKVLNLSHNNI---------------YTLTDKYNLES------KSLVELVF 615
+E QN T L+ +NL +N I + +K LE ++L +L
Sbjct: 119 VESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRL 178
Query: 616 SGNRL------------DILWNDDDNRYIS-------IFKGLKNLTRLDLSLNRLKHIPN 656
S N + ++L D + +S F GLKNL +L+L+ N L+ +P
Sbjct: 179 SQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPP 238
Query: 657 EAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFT-SSLR 715
+P ++ +L+++ N ++ + FP L + L NKL + F S+L
Sbjct: 239 ----RVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLPKNSFNISNLL 294
Query: 716 TLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTIN 752
L LSHNRIS +P + + L+HL L++N ++ IN
Sbjct: 295 VLHLSHNRISSVP----AINNRLEHLYLNNNSIEKIN 327
Score = 51.6 bits (122), Expect = 4e-06
Identities = 78/281 (27%), Positives = 124/281 (44%), Gaps = 59/281 (20%)
Query: 282 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPR-LE 340
+FQN T LR++NL + +RKI+ + +P L L +E N L E+ S LPR LE
Sbjct: 121 SFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLE-EVPSA-----LPRNLE 174
Query: 341 ILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQP--LMQLPNLST 398
L LS N+I P FSKL +L L L+ L + F+P L NL
Sbjct: 175 QLRLSQNHISRIPPGV------FSKLENLLLLDLQ---HNRLSDGVFKPDTFHGLKNLMQ 225
Query: 399 INLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTD 458
+NL N ++++ ++ L YL N+I + +S+ N + + + K
Sbjct: 226 LNLAHNILRKMPPRVPTAIHQL---YLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRG 282
Query: 459 FEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGP--NQFENLPDIACLNLSANS 516
N ++ + L+ L LS N I + N+ E+L LN N+
Sbjct: 283 LP----KNSFNISNLLV----------LHLSHNRISSVPAINNRLEHL----YLN---NN 321
Query: 517 NAQVLSGTE-----------FSA----IPHVKYLDLTNNRL 542
+ + ++GT+ FS+ +PH++YL L N L
Sbjct: 322 SIEKINGTQICPNDLVAFHDFSSDLENVPHLRYLRLDGNYL 362
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/105 (30%), Positives = 55/105 (52%), Gaps = 4/105 (3%)
Query: 644 LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFL 703
L L N + +P E+F N L +++++N ++ + +L++ P L L + N+L +
Sbjct: 107 LYLQNNFITELPVESFQNA-TGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEV 165
Query: 704 TDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLL 748
+L +L L LS N IS +P G S++ +L LDL N L
Sbjct: 166 PSALP---RNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRL 207
Score = 35.8 bits (81), Expect = 0.22
Identities = 75/326 (23%), Positives = 119/326 (36%), Gaps = 84/326 (25%)
Query: 394 PNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRK 453
P + + L NFI ++ + FQN + L I L NR IRK
Sbjct: 102 PRIHYLYLQNNFITELPVESFQNATGLRWINLDNNR---------------------IRK 140
Query: 454 RRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALD---LSLNSIFFIGPNQFENLPDIACL 510
E P F + + ++ +A + L+ LS N I I P F L ++ L
Sbjct: 141 IDQRVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLL 200
Query: 511 NLSANSNAQ-VLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFR 569
+L N + V F + ++ L+L +N L T + L LD + +
Sbjct: 201 DLQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQL-YLDSN------K 253
Query: 570 IAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDN 629
I + + + ++F NL + L++N LTD+ L S
Sbjct: 254 IETIPN--GYFKSFPNLAFIRLNYNK---LTDR-GLPKNSF------------------- 288
Query: 630 RYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTL------ 683
+ NL L LS NR+ +P + L L++N+N ++ N T
Sbjct: 289 -------NISNLLVLHLSHNRISSVP-----AINNRLEHLYLNNNSIEKINGTQICPNDL 336
Query: 684 ---------LQQFPRLELLDLRGNKL 700
L+ P L L L GN L
Sbjct: 337 VAFHDFSSDLENVPHLRYLRLDGNYL 362
>gi|4506041 proline arginine-rich end leucine-rich repeat protein
precursor [Homo sapiens]
Length = 382
Score = 99.0 bits (245), Expect = 2e-20
Identities = 87/299 (29%), Positives = 136/299 (45%), Gaps = 49/299 (16%)
Query: 49 CSNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHNPNVQHQNGNPG 108
C +R L++VP + + L L +NFIT + ESFQ L INL++N
Sbjct: 89 CDSRNLRKVP-VIPPRIHYLYLQNNFITELPVESFQNATGLRWINLDNN----------- 136
Query: 109 IQSNGLNITDGAFLNLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITKEGISR 168
I L L L +E NQL ++PS LP +L +L L QN+I I S+
Sbjct: 137 ---RIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSK 193
Query: 169 LINLKNLYLAWNCYFNKVCEKTNIEDGVFET-----LTNLELLSLSFNSLSHVPPKLPSS 223
L NL L L N + DGVF+ L NL L+L+ N L +PP++P++
Sbjct: 194 LENLLLLDLQHN----------RLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTA 243
Query: 224 LRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAF 283
+ +L+L + +I+ I FK NL + L+ N P +++
Sbjct: 244 IHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLPKNSFNISNLLVLHLSHNRI 303
Query: 284 QNL----TQLRYLNLSSTSLRKIN---------------AAWFKNMPHLKVLDLEFNYL 323
++ +L +L L++ S+ KIN ++ +N+PHL+ L L+ NYL
Sbjct: 304 SSVPAINNRLEHLYLNNNSIEKINGTQICPNDLVAFHDFSSDLENVPHLRYLRLDGNYL 362
Score = 55.5 bits (132), Expect = 3e-07
Identities = 59/217 (27%), Positives = 99/217 (45%), Gaps = 49/217 (22%)
Query: 577 LEFIQNFTNLKVLNLSHNNI---------------YTLTDKYNLES------KSLVELVF 615
+E QN T L+ +NL +N I + +K LE ++L +L
Sbjct: 119 VESFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRL 178
Query: 616 SGNRL------------DILWNDDDNRYIS-------IFKGLKNLTRLDLSLNRLKHIPN 656
S N + ++L D + +S F GLKNL +L+L+ N L+ +P
Sbjct: 179 SQNHISRIPPGVFSKLENLLLLDLQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPP 238
Query: 657 EAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSLSDFT-SSLR 715
+P ++ +L+++ N ++ + FP L + L NKL + F S+L
Sbjct: 239 ----RVPTAIHQLYLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRGLPKNSFNISNLL 294
Query: 716 TLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLLKTIN 752
L LSHNRIS +P + + L+HL L++N ++ IN
Sbjct: 295 VLHLSHNRISSVP----AINNRLEHLYLNNNSIEKIN 327
Score = 51.6 bits (122), Expect = 4e-06
Identities = 78/281 (27%), Positives = 124/281 (44%), Gaps = 59/281 (20%)
Query: 282 AFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIASGAFLTMLPR-LE 340
+FQN T LR++NL + +RKI+ + +P L L +E N L E+ S LPR LE
Sbjct: 121 SFQNATGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLE-EVPSA-----LPRNLE 174
Query: 341 ILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQP--LMQLPNLST 398
L LS N+I P FSKL +L L L+ L + F+P L NL
Sbjct: 175 QLRLSQNHISRIPPGV------FSKLENLLLLDLQ---HNRLSDGVFKPDTFHGLKNLMQ 225
Query: 399 INLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRKRRSTD 458
+NL N ++++ ++ L YL N+I + +S+ N + + + K
Sbjct: 226 LNLAHNILRKMPPRVPTAIHQL---YLDSNKIETIPNGYFKSFPNLAFIRLNYNKLTDRG 282
Query: 459 FEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGP--NQFENLPDIACLNLSANS 516
N ++ + L+ L LS N I + N+ E+L LN N+
Sbjct: 283 LP----KNSFNISNLLV----------LHLSHNRISSVPAINNRLEHL----YLN---NN 321
Query: 517 NAQVLSGTE-----------FSA----IPHVKYLDLTNNRL 542
+ + ++GT+ FS+ +PH++YL L N L
Sbjct: 322 SIEKINGTQICPNDLVAFHDFSSDLENVPHLRYLRLDGNYL 362
Score = 44.7 bits (104), Expect = 5e-04
Identities = 32/105 (30%), Positives = 55/105 (52%), Gaps = 4/105 (3%)
Query: 644 LDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFL 703
L L N + +P E+F N L +++++N ++ + +L++ P L L + N+L +
Sbjct: 107 LYLQNNFITELPVESFQNA-TGLRWINLDNNRIRKIDQRVLEKLPGLVFLYMEKNQLEEV 165
Query: 704 TDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNLL 748
+L +L L LS N IS +P G S++ +L LDL N L
Sbjct: 166 PSALP---RNLEQLRLSQNHISRIPPGVFSKLENLLLLDLQHNRL 207
Score = 35.8 bits (81), Expect = 0.22
Identities = 75/326 (23%), Positives = 119/326 (36%), Gaps = 84/326 (25%)
Query: 394 PNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQRHIRK 453
P + + L NFI ++ + FQN + L I L NR IRK
Sbjct: 102 PRIHYLYLQNNFITELPVESFQNATGLRWINLDNNR---------------------IRK 140
Query: 454 RRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALD---LSLNSIFFIGPNQFENLPDIACL 510
E P F + + ++ +A + L+ LS N I I P F L ++ L
Sbjct: 141 IDQRVLEKLPGLVFLYMEKNQLEEVPSALPRNLEQLRLSQNHISRIPPGVFSKLENLLLL 200
Query: 511 NLSANSNAQ-VLSGTEFSAIPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSHYFR 569
+L N + V F + ++ L+L +N L T + L LD + +
Sbjct: 201 DLQHNRLSDGVFKPDTFHGLKNLMQLNLAHNILRKMPPRVPTAIHQL-YLDSN------K 253
Query: 570 IAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDDDN 629
I + + + ++F NL + L++N LTD+ L S
Sbjct: 254 IETIPN--GYFKSFPNLAFIRLNYNK---LTDR-GLPKNSF------------------- 288
Query: 630 RYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTL------ 683
+ NL L LS NR+ +P + L L++N+N ++ N T
Sbjct: 289 -------NISNLLVLHLSHNRISSVP-----AINNRLEHLYLNNNSIEKINGTQICPNDL 336
Query: 684 ---------LQQFPRLELLDLRGNKL 700
L+ P L L L GN L
Sbjct: 337 VAFHDFSSDLENVPHLRYLRLDGNYL 362
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.137 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,395,406
Number of Sequences: 37866
Number of extensions: 1556817
Number of successful extensions: 8705
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 173
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 3781
Number of HSP's gapped (non-prelim): 2089
length of query: 1041
length of database: 18,247,518
effective HSP length: 112
effective length of query: 929
effective length of database: 14,006,526
effective search space: 13012062654
effective search space used: 13012062654
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.