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Search of human proteins with 20143971
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20143971 toll-like receptor 6 [Homo sapiens]
(796 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20143971 toll-like receptor 6 [Homo sapiens] 1604 0.0
gi|41350337 toll-like receptor 1 [Homo sapiens] 1093 0.0
gi|62865621 toll-like receptor 10 precursor [Homo sapiens] 730 0.0
gi|62865618 toll-like receptor 10 precursor [Homo sapiens] 730 0.0
gi|19718734 toll-like receptor 2 [Homo sapiens] 349 5e-96
gi|19924149 toll-like receptor 4 precursor [Homo sapiens] 159 1e-38
gi|20302168 toll-like receptor 8 [Homo sapiens] 146 8e-35
gi|4507531 toll-like receptor 3 [Homo sapiens] 142 9e-34
gi|7706093 toll-like receptor 7 [Homo sapiens] 130 5e-30
gi|16751843 toll-like receptor 5 [Homo sapiens] 130 6e-30
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 108 2e-23
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 73 9e-13
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 73 9e-13
gi|4504661 interleukin 1 receptor accessory protein isoform 1 [H... 69 1e-11
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 64 7e-10
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 64 7e-10
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 63 1e-09
gi|238908508 leucine-rich repeat and death domain-containing pro... 62 2e-09
gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens] 61 4e-09
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 59 1e-08
gi|65301141 PH domain and leucine rich repeat protein phosphatas... 58 4e-08
gi|19923729 leucine rich repeat containing 8 family, member C [H... 58 4e-08
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 57 5e-08
gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens] 57 5e-08
gi|52353306 leucine rich repeat containing 55 [Homo sapiens] 57 5e-08
gi|153791466 AMIGO protein [Homo sapiens] 57 9e-08
gi|150417978 platelet glycoprotein Ib alpha polypeptide precurso... 56 1e-07
gi|41350214 asporin [Homo sapiens] 56 1e-07
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 56 1e-07
gi|188528675 slit homolog 1 [Homo sapiens] 55 3e-07
>gi|20143971 toll-like receptor 6 [Homo sapiens]
Length = 796
Score = 1604 bits (4154), Expect = 0.0
Identities = 796/796 (100%), Positives = 796/796 (100%)
Query: 1 MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMS 60
MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMS
Sbjct: 1 MTKDKEPIVKSFHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMS 60
Query: 61 QNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPI 120
QNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPI
Sbjct: 61 QNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPI 120
Query: 121 VSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRN 180
VSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRN
Sbjct: 121 VSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRN 180
Query: 181 YYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIK 240
YYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIK
Sbjct: 181 YYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIK 240
Query: 241 FLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYS 300
FLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYS
Sbjct: 241 FLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYS 300
Query: 301 KTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNF 360
KTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNF
Sbjct: 301 KTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNF 360
Query: 361 TQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRH 420
TQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRH
Sbjct: 361 TQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRH 420
Query: 421 KENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNV 480
KENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNV
Sbjct: 421 KENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNV 480
Query: 481 AFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREF 540
AFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREF
Sbjct: 481 AFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREF 540
Query: 541 VKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAV 600
VKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAV
Sbjct: 541 VKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAV 600
Query: 601 TVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSEL 660
TVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSEL
Sbjct: 601 TVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSEL 660
Query: 661 VPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
VPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH
Sbjct: 661 VPYLEKEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Query: 721 HNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA 780
HNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA
Sbjct: 721 HNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA 780
Query: 781 FNMKLTLVTENNDVKS 796
FNMKLTLVTENNDVKS
Sbjct: 781 FNMKLTLVTENNDVKS 796
>gi|41350337 toll-like receptor 1 [Homo sapiens]
Length = 786
Score = 1093 bits (2827), Expect = 0.0
Identities = 540/777 (69%), Positives = 631/777 (81%), Gaps = 2/777 (0%)
Query: 12 FHFVCLMIIIVGTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSD 71
FHF + ++I+ RIQ S+ +EF VD+SK GLIHVPKDL KT +L++SQNYI+EL SD
Sbjct: 5 FHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELWTSD 64
Query: 72 MSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFN 131
+ LS+L +L +SHNRIQ LD+SVFKFNQ+LEYLDLSHN+L KISCHP V+ +HLDLSFN
Sbjct: 65 ILSLSKLRILIISHNRIQYLDISVFKFNQELEYLDLSHNKLVKISCHPTVNLKHLDLSFN 124
Query: 132 DFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESL 191
F ALPICKEFGN+SQL FLGLS L+K +LPIAHL++S +LL L Y ++ + E L
Sbjct: 125 AFDALPICKEFGNMSQLKFLGLSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEGL 184
Query: 192 QILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIK--LNDDNCQVFIKFLSELTRGS 249
Q N ++LH+VF F +++SV T+ L+L+NIK L D+ C F+ L++L
Sbjct: 185 QDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNP 244
Query: 250 TLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTI 309
L N TLN+IETTW +R+ Q +W V Y +I N+ + + DF YS T+LKAL+I
Sbjct: 245 KLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDYSGTSLKALSI 304
Query: 310 EHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSI 369
+ + VF F Q+ +Y +FS MNI T+S T +HMLCP S F L+F+ N+ TD++
Sbjct: 305 HQVVSDVFGFPQSYIYEIFSNMNIKNFTVSGTRMVHMLCPSKISPFLHLDFSNNLLTDTV 364
Query: 370 FEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVES 429
FE C L +LETLILQ N LK+L K+ MT M SL+ LD+S NS+ K +C+W +S
Sbjct: 365 FENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVSYDEKKGDCSWTKS 424
Query: 430 IVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLP 489
++ LN+SSN+LTD++FRCLPPRIKVLDLHSNKIKS+PKQVVKLEALQELNVAFNSLTDLP
Sbjct: 425 LLSLNMSSNILTDTIFRCLPPRIKVLDLHSNKIKSIPKQVVKLEALQELNVAFNSLTDLP 484
Query: 490 GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSS 549
GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCEL EFVKNIDQVSS
Sbjct: 485 GCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELGEFVKNIDQVSS 544
Query: 550 EVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYL 609
EVLEGWPDSYKCDYPESYRG+ LKDFHMSELSCNITLLIVTI ATMLVLAVTVTSLC YL
Sbjct: 545 EVLEGWPDSYKCDYPESYRGTLLKDFHMSELSCNITLLIVTIVATMLVLAVTVTSLCSYL 604
Query: 610 DLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKEDI 669
DLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYS HDS WVK+EL+P LEKE +
Sbjct: 605 DLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSGHDSFWVKNELLPNLEKEGM 664
Query: 670 QICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSN 729
QICLHERNFVPGKSIVENII CIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSN
Sbjct: 665 QICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSN 724
Query: 730 NLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMKLT 786
+LILILLEPIPQ SIP+ YHKLK+LM +RTYL+WPKEKSKRGLFWAN+RAA N+KLT
Sbjct: 725 SLILILLEPIPQYSIPSSYHKLKSLMARRTYLEWPKEKSKRGLFWANLRAAINIKLT 781
>gi|62865621 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 730 bits (1885), Expect = 0.0
Identities = 382/799 (47%), Positives = 527/799 (65%), Gaps = 21/799 (2%)
Query: 8 IVKSFHFVCLMIIIV-GTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAE 66
++++ + C +++ G + + E + S L VP DL T LD+S N + +
Sbjct: 3 LIRNIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQ 62
Query: 67 LQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHL 126
LQ SD +S+L VL L HNRIQ LDL F+FN++L YLDLS+N+L+ ++ + + R+L
Sbjct: 63 LQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYL 122
Query: 127 DLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKEN 186
DLSFNDF +PIC+E GN+S L LGLS K+QK D IAHLHL+ + L R +
Sbjct: 123 DLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRT--LPHY 180
Query: 187 ETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELT 246
E SL ILN LH+V + F + + + T L++TNI D F+ + E+
Sbjct: 181 EEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNI----DGKSQFVSY--EMQ 234
Query: 247 RGSTLLN-----FTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIES--IREEDFTY 299
R +L N LN ++ W L + QF+W VE+ I N+T + F Y
Sbjct: 235 RNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDY 294
Query: 300 SKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLN 359
S T ++ + +EH+ +VF Q +Y + ++M+I LTIS+ HML P+ P+ F++LN
Sbjct: 295 SNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLN 354
Query: 360 FTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGR 419
F N+ TD +F++ L L+TLIL N L+ L V + P LE LD+S N L+ +
Sbjct: 355 FANNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTP-LEHLDLSQNLLQH-K 412
Query: 420 HKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELN 479
+ ENC+W E++V +NLS N L+DSVFRCLP I++LDL++N+I++VPK+ + L AL+ELN
Sbjct: 413 NDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELN 472
Query: 480 VAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELRE 539
+AFN LTDLPGC FS LSVL I+ N + PS DF QSCQ+++++ AG NPF+CTCEL+
Sbjct: 473 IAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKN 532
Query: 540 FVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLA 599
F++ ++ S ++ GW DSY C+YP + RG+ LKD H+ ELSCN LLIVTI MLVL
Sbjct: 533 FIQ-LETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLG 591
Query: 600 VTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSE 659
+ V C++ DLPWYLRM+ Q TQT R R E+L+RN++FHAFISYSEHDS WVK+E
Sbjct: 592 LAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNE 651
Query: 660 LVPYLEKED--IQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELY 717
L+P LEKED I ICL+E F PGKSI ENI++ IEKSYKSIFVLSPNFVQ+EWCHYE Y
Sbjct: 652 LIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFY 711
Query: 718 FAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANI 777
FAHHNLFHE S+++ILILLEPIP IP +YHKLKAL+ ++ YL+WPK++ K GLFWAN+
Sbjct: 712 FAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANL 771
Query: 778 RAAFNMKLTLVTENNDVKS 796
RAA N+ + E ++++
Sbjct: 772 RAAINVNVLATREMYELQT 790
>gi|62865618 toll-like receptor 10 precursor [Homo sapiens]
Length = 811
Score = 730 bits (1885), Expect = 0.0
Identities = 382/799 (47%), Positives = 527/799 (65%), Gaps = 21/799 (2%)
Query: 8 IVKSFHFVCLMIIIV-GTRIQFSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAE 66
++++ + C +++ G + + E + S L VP DL T LD+S N + +
Sbjct: 3 LIRNIYIFCSIVMTAEGDAPELPEERELMTNCSNMSLRKVPADLTPATTTLDLSYNLLFQ 62
Query: 67 LQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHL 126
LQ SD +S+L VL L HNRIQ LDL F+FN++L YLDLS+N+L+ ++ + + R+L
Sbjct: 63 LQSSDFHSVSKLRVLILCHNRIQQLDLKTFEFNKELRYLDLSNNRLKSVTWYLLAGLRYL 122
Query: 127 DLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKEN 186
DLSFNDF +PIC+E GN+S L LGLS K+QK D IAHLHL+ + L R +
Sbjct: 123 DLSFNDFDTMPICEEAGNMSHLEILGLSGAKIQKSDFQKIAHLHLNTVFLGFRT--LPHY 180
Query: 187 ETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELT 246
E SL ILN LH+V + F + + + T L++TNI D F+ + E+
Sbjct: 181 EEGSLPILNTTKLHIVLPMDTNFWVLLRDGIKTSKILEMTNI----DGKSQFVSY--EMQ 234
Query: 247 RGSTLLN-----FTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIES--IREEDFTY 299
R +L N LN ++ W L + QF+W VE+ I N+T + F Y
Sbjct: 235 RNLSLENAKTSVLLLNKVDLLWDDLFLILQFVWHTSVEHFQIRNVTFGGKAYLDHNSFDY 294
Query: 300 SKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLN 359
S T ++ + +EH+ +VF Q +Y + ++M+I LTIS+ HML P+ P+ F++LN
Sbjct: 295 SNTVMRTIKLEHVHFRVFYIQQDKIYLLLTKMDIENLTISNAQMPHMLFPNYPTKFQYLN 354
Query: 360 FTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGR 419
F N+ TD +F++ L L+TLIL N L+ L V + P LE LD+S N L+ +
Sbjct: 355 FANNILTDELFKRTIQLPHLKTLILNGNKLETLSLVSCFANNTP-LEHLDLSQNLLQH-K 412
Query: 420 HKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELN 479
+ ENC+W E++V +NLS N L+DSVFRCLP I++LDL++N+I++VPK+ + L AL+ELN
Sbjct: 413 NDENCSWPETVVNMNLSYNKLSDSVFRCLPKSIQILDLNNNQIQTVPKETIHLMALRELN 472
Query: 480 VAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELRE 539
+AFN LTDLPGC FS LSVL I+ N + PS DF QSCQ+++++ AG NPF+CTCEL+
Sbjct: 473 IAFNFLTDLPGCSHFSRLSVLNIEMNFILSPSLDFVQSCQEVKTLNAGRNPFRCTCELKN 532
Query: 540 FVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLA 599
F++ ++ S ++ GW DSY C+YP + RG+ LKD H+ ELSCN LLIVTI MLVL
Sbjct: 533 FIQ-LETYSEVMMVGWSDSYTCEYPLNLRGTRLKDVHLHELSCNTALLIVTIVVIMLVLG 591
Query: 600 VTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSE 659
+ V C++ DLPWYLRM+ Q TQT R R E+L+RN++FHAFISYSEHDS WVK+E
Sbjct: 592 LAVAFCCLHFDLPWYLRMLGQCTQTWHRVRKTTQEQLKRNVRFHAFISYSEHDSLWVKNE 651
Query: 660 LVPYLEKED--IQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELY 717
L+P LEKED I ICL+E F PGKSI ENI++ IEKSYKSIFVLSPNFVQ+EWCHYE Y
Sbjct: 652 LIPNLEKEDGSILICLYESYFDPGKSISENIVSFIEKSYKSIFVLSPNFVQNEWCHYEFY 711
Query: 718 FAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANI 777
FAHHNLFHE S+++ILILLEPIP IP +YHKLKAL+ ++ YL+WPK++ K GLFWAN+
Sbjct: 712 FAHHNLFHENSDHIILILLEPIPFYCIPTRYHKLKALLEKKAYLEWPKDRRKCGLFWANL 771
Query: 778 RAAFNMKLTLVTENNDVKS 796
RAA N+ + E ++++
Sbjct: 772 RAAINVNVLATREMYELQT 790
>gi|19718734 toll-like receptor 2 [Homo sapiens]
Length = 784
Score = 349 bits (896), Expect = 5e-96
Identities = 241/766 (31%), Positives = 398/766 (51%), Gaps = 47/766 (6%)
Query: 39 SKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKF 98
S L +P L K LD+S N I + SD+ L L L+ N I ++ F
Sbjct: 39 SSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSS 98
Query: 99 NQDLEYLDLSHNQLQKISCH---PIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSA 155
LE+LDLS+N L +S P+ S L+L N +K L F +L++L L +
Sbjct: 99 LGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGN 158
Query: 156 M----KLQKLDLLPIAHLH-LSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFA 210
M K+Q+ D + L L DL++Y K +S+Q ++ LH+ H +
Sbjct: 159 MDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKS--LKSIQNVSHLILHMKQH---ILL 213
Query: 211 IQVNISV-NTLGCLQLTNIKLNDDNCQVFIKFLSELTRGST---LLNFTLNHIETTWKCL 266
+++ + V +++ CL+L + L+ + SEL+ G T + FT +++ T + L
Sbjct: 214 LEIFVDVTSSVECLELRDTDLDTFH-------FSELSTGETNSLIKKFTFRNVKITDESL 266
Query: 267 VRVFQFLWP-KPVEYLNIYNLTI--IESIR--EEDFTYSKTTLKALTIE--HITNQVFLF 319
+V + L + L + T+ + + R + D ++ LTI HI +
Sbjct: 267 FQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFY 326
Query: 320 SQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCS---TL 376
+ LY++ + + + S + L + ++L+ ++N+ + + +
Sbjct: 327 DLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAW 386
Query: 377 VKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLS 436
L+TLIL++N L L K G + +L +D+S NS S E C W E + LNLS
Sbjct: 387 PSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHS--MPETCQWPEKMKYLNLS 444
Query: 437 SNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSS 496
S + SV C+P +++LD+ +N + + L L+EL ++ N L LP
Sbjct: 445 STRI-HSVTGCIPKTLEILDVSNNNLNLFS---LNLPQLKELYISRNKLMTLPDASLLPM 500
Query: 497 LSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWP 556
L VL I N+++ S + S +++++AG N F C+CE F + Q ++VL WP
Sbjct: 501 LLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQE-QQALAKVLIDWP 559
Query: 557 DSYKCDYPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLR 616
+Y CD P RG ++D +S C+ T L+ + + +L + LC WY++
Sbjct: 560 ANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMK 619
Query: 617 MVCQWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKED--IQICLH 674
M+ W Q +R+ R P RN+ + AF+SYSE D+ WV++ +V LE + ++CLH
Sbjct: 620 MMWAWLQAKRKPRKAP----SRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLH 675
Query: 675 ERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILI 734
+R+F+PGK I++NII+ IEKS+K++FVLS NFV+SEWC YEL F+H LF E ++ ILI
Sbjct: 676 KRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILI 735
Query: 735 LLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA 780
LLEPI + +IP ++ KL+ +M +TYL+WP ++++R FW N+RAA
Sbjct: 736 LLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAA 781
>gi|19924149 toll-like receptor 4 precursor [Homo sapiens]
Length = 839
Score = 159 bits (402), Expect = 1e-38
Identities = 200/809 (24%), Positives = 356/809 (44%), Gaps = 116/809 (14%)
Query: 46 VPKDLPLKTKVLDMSQNYI-----------AELQVSDMS-------------FLSELTVL 81
+P +LP TK LD+S N + ELQV D+S LS L+ L
Sbjct: 48 IPDNLPFSTKNLDLSFNPLRHLGSYSFFSFPELQVLDLSRCEIQTIEDGAYQSLSHLSTL 107
Query: 82 RLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPI---VSFRHLDLSFNDFKALPI 138
L+ N IQ L L F L+ L L + PI + + L+++ N ++ +
Sbjct: 108 ILTGNPIQSLALGAFSGLSSLQKLVAVETNLASLENFPIGHLKTLKELNVAHNLIQSFKL 167
Query: 139 CKEFGNLSQLNFLGLSAMKLQKL---DLLPIAHLHLSYILLDLRNYYIKENETESLQILN 195
+ F NL+ L L LS+ K+Q + DL + + L + LDL + + + + +
Sbjct: 168 PEYFSNLTNLEHLDLSSNKIQSIYCTDLRVLHQMPLLNLSLDLSLNPMNFIQPGAFKEIR 227
Query: 196 AKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKL----NDDNCQVFIKFLSELTRGSTL 251
L L + SL ++ + L L++ + L N+ N + F K E T+
Sbjct: 228 LHKLTLRNNFDSLNVMKT--CIQGLAGLEVHRLVLGEFRNEGNLEKFDKSALEGLCNLTI 285
Query: 252 LNFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYS----------- 300
F L +++ ++ +F L ++ ++L + R +DF+Y+
Sbjct: 286 EEFRLAYLDYYLDDIIDLFNCL-----TNVSSFSLVSVTIERVKDFSYNFGWQHLELVNC 340
Query: 301 ----KTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTP----FIHMLCPHA- 351
TLK +++ +T F+ FSE+++ L D C +
Sbjct: 341 KFGQFPTLKLKSLKRLT-----FTSNKGGNAFSEVDLPSLEFLDLSRNGLSFKGCCSQSD 395
Query: 352 --PSTFKFLNFTQN-VFTDSIFEKCSTLVKLETLILQKNGLKDL--FKVGLMTKDMPSLE 406
++ K+L+ + N V T S L +LE L Q + LK + F V L +++ L+
Sbjct: 396 FGTTSLKYLDLSFNGVITMS--SNFLGLEQLEHLDFQHSNLKQMSEFSVFLSLRNLIYLD 453
Query: 407 I----LDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIK---VLDLHS 459
I V++N + +G + S+ VL ++ N ++ + ++ LDL
Sbjct: 454 ISHTHTRVAFNGIFNG--------LSSLEVLKMAGNSFQENFLPDIFTELRNLTFLDLSQ 505
Query: 460 NKIKSV-PKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSC 518
+++ + P L +LQ LN++ N+ L S+ ++D+ S++H Q
Sbjct: 506 CQLEQLSPTAFNSLSSLQVLNMSHNNFFSLDTFPYKCLNSLQVLDY-SLNHIMTSKKQEL 564
Query: 519 QKMRS----IKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKD 574
Q S + N F CTCE + F++ I ++E + +C P +G P+
Sbjct: 565 QHFPSSLAFLNLTQNDFACTCEHQSFLQWIKDQRQLLVE--VERMECATPSDKQGMPVLS 622
Query: 575 FHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLE 634
+ ++C + I+ + + + VL V+V ++ +Y ++ M+ R NI
Sbjct: 623 LN---ITCQMNKTIIGV-SVLSVLVVSVVAVLVYKF--YFHLMLLAGCIKYGRGENI--- 673
Query: 635 ELQRNLQFHAFISYSEHDSAWVKSELVPYLEK--EDIQICLHERNFVPGKSIVENIIN-C 691
+ AF+ YS D WV++ELV LE+ Q+CLH R+F+PG +I NII+
Sbjct: 674 -------YDAFVIYSSQDEDWVRNELVKNLEEGVPPFQLCLHYRDFIPGVAIAANIIHEG 726
Query: 692 IEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKL 751
KS K I V+S +F+QS WC +E A F +I I+L+ + + ++ + +L
Sbjct: 727 FHKSRKVIVVVSQHFIQSRWCIFEYEIAQTWQFLSSRAGIIFIVLQKV-EKTLLRQQVEL 785
Query: 752 KALMTQRTYLQWPKEKSKRGLFWANIRAA 780
L+++ TYL+W R +FW +R A
Sbjct: 786 YRLLSRNTYLEWEDSVLGRHIFWRRLRKA 814
>gi|20302168 toll-like receptor 8 [Homo sapiens]
Length = 1041
Score = 146 bits (368), Expect = 8e-35
Identities = 199/828 (24%), Positives = 348/828 (42%), Gaps = 105/828 (12%)
Query: 39 SKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQL-------- 90
S L HVP LP + L +S I + D L LT+L LS N +
Sbjct: 209 SFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFKGLINLTLLDLSGNCPRCFNAPFPCV 268
Query: 91 ---------LDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHL---DLSFNDFKALPI 138
+D F+ L YL+LS L+KI+ + HL DL FN
Sbjct: 269 PCDGGASINIDRFAFQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYLVGEIA 328
Query: 139 CKEFGN-LSQLNFLGLSAMKL-----QKLDLLPIAHLHLSYILLDLRNYYIKENETESLQ 192
F L +L L LS + Q +++ LS L LR Y +E + Q
Sbjct: 329 SGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNFSKLLSLRALHLRGYVFQELREDDFQ 388
Query: 193 IL----NAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLND---DNCQVFIKFLS-- 243
L N T++L + ++ + + L + L+ +++ D Q + S
Sbjct: 389 PLMQLPNLSTINLGINFIKQIDFKLFQNFSNLEIIYLSENRISPLVKDTRQSYANSSSFQ 448
Query: 244 -----------ELTRGSTLLNFTLNHIETTWKCLVRVFQF-----LWPKPVEYLNIYNLT 287
E S +FT I+ + + P ++ N+ ++
Sbjct: 449 RHIRKRRSTDFEFDPHSNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDIA 508
Query: 288 IIE-SIREEDFTYSKTTLKALTIEHI-----TNQVFLFSQTALYTVFSEMNIMMLTISDT 341
+ S S T A I H+ TN F + T S++ ++ L+ +
Sbjct: 509 CLNLSANSNAQVLSGTEFSA--IPHVKYLDLTNNRLDFDNASALTELSDLEVLDLSYNSH 566
Query: 342 PFI------HMLCPHAPSTFKFLNFTQN---VFTDSIFEKCSTLVKLETLILQKNGLKDL 392
F H+ + K LN + N TD + +LV+L + N L L
Sbjct: 567 YFRIAGVTHHLEFIQNFTNLKVLNLSHNNIYTLTDKYNLESKSLVEL---VFSGNRLDIL 623
Query: 393 F-----KVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRC 447
+ + + K + +L LD+S N L+ ++ S+ L+++ NML +
Sbjct: 624 WNDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLTELHINDNMLKFFNWTL 683
Query: 448 LP--PRIKVLDLHSNKIKSVPKQVVKL-EALQELNVAFNSLTDLPG--CGSFSSLSVLII 502
L PR+++LDL NK+ + + +L+ L ++ N ++ LP SSL L +
Sbjct: 684 LQQFPRLELLDLRGNKLLFLTDSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDL 743
Query: 503 DHNSVS--HPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYK 560
N + + SA ++ K+ ++ NPF+CTC++ +F + +D+ + + D
Sbjct: 744 SSNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWMDEHLNVKIPRLVDVI- 802
Query: 561 CDYPESYRGSPLKDFHMSELSCNITLLIV---TIGATMLVLAVTVTSLCIYLDLPWYLRM 617
C P RG + ++ ++T +I+ T T +V+ + Y D+ W++
Sbjct: 803 CASPGDQRGKSIVSLELTTCVSDVTAVILFFFTFFITTMVMLAALAHHLFYWDV-WFIYN 861
Query: 618 VCQWTQTRRRARNIPLEELQRNLQFH-AFISYSEHDSA---WVKSELVPYLEK---EDIQ 670
VC A+ L + F+ A+ISY D++ WV +EL +LE+ +++
Sbjct: 862 VCL-------AKVKGYRSLSTSQTFYDAYISYDTKDASVTDWVINELRYHLEESRDKNVL 914
Query: 671 ICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNN 730
+CL ER++ PG +I++N++ I +S K++FVL+ + +S Y A L E +
Sbjct: 915 LCLEERDWDPGLAIIDNLMQSINQSKKTVFVLTKKYAKSWNFKTAFYLALQRLMDENMDV 974
Query: 731 LILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIR 778
+I ILLEP+ Q+S +Y +L+ + + + LQWP GLFW +R
Sbjct: 975 IIFILLEPVLQHS---QYLRLRQRICKSSILQWPDNPKAEGLFWQTLR 1019
Score = 30.4 bits (67), Expect = 6.7
Identities = 16/48 (33%), Positives = 23/48 (47%)
Query: 39 SKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHN 86
S R L VP+ + LD+S N+I + L LT + L+HN
Sbjct: 50 SNRRLQEVPQTVGKYVTELDLSDNFITHITNESFQGLQNLTKINLNHN 97
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 142 bits (359), Expect = 9e-34
Identities = 206/886 (23%), Positives = 356/886 (40%), Gaps = 159/886 (17%)
Query: 37 DKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELT----------------- 79
D S L VP DLP VL+++ N + L ++ + S+LT
Sbjct: 36 DCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELC 95
Query: 80 -------VLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHL---DLS 129
VL L HN + L F F +L L L N +QKI +P V ++L DLS
Sbjct: 96 QKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLS 155
Query: 130 FNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETE 189
N + + + L L L LS K+Q L S L N +K+ E
Sbjct: 156 HNGLSSTKLGTQV-QLENLQELLLSNNKIQALK---------SEELDIFANSSLKKLELS 205
Query: 190 SLQI--LNAKTLHLVFHPTSLFA--IQVNISVNTLGCLQLTNIKLND---DNCQVFIK-- 240
S QI + H + LF +Q+ S+ CL+L N + + N Q+
Sbjct: 206 SNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSN 265
Query: 241 --FLSELTRGSTLLNFTLNHIETT------WKCLVRVFQFLWPKPVEYLNIYNLTIIESI 292
FL T+L+ + N++ W + F FL +++L ++L + ++
Sbjct: 266 TTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYF-FLEYNNIQHLFSHSLHGLFNV 324
Query: 293 R----EEDFTYSKTTLKALT------------IEH----------ITNQVFLFSQTALYT 326
R + FT +L +L +EH I + +F Y
Sbjct: 325 RYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYL 384
Query: 327 VFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQK 386
S + T+++ F+ + A S LN T+N + + S L LE L L
Sbjct: 385 SLSNSFTSLRTLTNETFVSL----AHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGL 440
Query: 387 N------------GLKDLFKVGL-------MTKD----MPSLE----------------- 406
N GL+++F++ L +T++ +PSL+
Sbjct: 441 NEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPS 500
Query: 407 ---------ILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLP-------- 449
ILD+S N++ + + + +E + +L+L N L P
Sbjct: 501 PFQPLRNLTILDLSNNNI-ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLK 559
Query: 450 --PRIKVLDLHSNKIKSVPKQVVK-LEALQELNVAFNSLTDLPGC--GSFSSLSVLIIDH 504
+ +L+L SN +P +V K L L+ +++ N+L LP + SL L +
Sbjct: 560 GLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQK 619
Query: 505 NSVSHPSADFF-QSCQKMRSIKAGDNPFQCTCE-LREFVKNIDQVSSEVLEGWPDSYKCD 562
N ++ F + + + + NPF CTCE + FV I++ + + E Y C+
Sbjct: 620 NLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPE-LSSHYLCN 678
Query: 563 YPESYRGSPLKDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWT 622
P Y G P++ F S + + + T ++L L I+ + W R+ W
Sbjct: 679 TPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFE-GW--RISFYWN 735
Query: 623 QTRRRARNIP-LEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKED--IQICLHERNFV 679
+ R ++ ++ A+I ++ D WV E +EKED ++ CL ER+F
Sbjct: 736 VSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVW-EHFSSMEKEDQSLKFCLEERDFE 794
Query: 680 PGKSIVENIINCIEKSYKSIFVLSPNFVQSEWC-HYELYFAHHNLFHEGSNNLILILLEP 738
G +E I+N I++S K IFV++ + ++ C ++++ A + +++IL+ LE
Sbjct: 795 AGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEE 854
Query: 739 IPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAAFNMK 784
IP + + + + L WP +K + G F ++ A K
Sbjct: 855 IPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSK 900
>gi|7706093 toll-like receptor 7 [Homo sapiens]
Length = 1049
Score = 130 bits (327), Expect = 5e-30
Identities = 186/815 (22%), Positives = 337/815 (41%), Gaps = 144/815 (17%)
Query: 66 ELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKIS-----CHPI 120
++ V+ L+EL VLRL N +Q + FK L+ LDLS N L K H +
Sbjct: 280 QIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFL 339
Query: 121 VSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRN 180
S LDLSFN L + + NLSQ F L ++K+ ++ Y+ +L++
Sbjct: 340 PSLIQLDLSFNF--ELQVYRASMNLSQA-FSSLKSLKILRIR---------GYVFKELKS 387
Query: 181 YYIKE-NETESLQILNAKTLHLVFHPTSLFAI-----QVNISVNTL---------GCLQL 225
+ + + ++L++L+ T + S+F +++SVN + G
Sbjct: 388 FNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSN 447
Query: 226 TNIKLNDDNCQVFIKF----LSELTRGSTLLNFTLNHIETTWKC---------------L 266
+ QV + + R N + + C
Sbjct: 448 ARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFF 507
Query: 267 VRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYT 326
V+ F ++ LN+ I +++ +F + + ++ N++ L TA
Sbjct: 508 VKSSDFQHLSFLKCLNLSGNLISQTLNGSEF---QPLAELRYLDFSNNRLDLLHSTA--- 561
Query: 327 VFSEMN-IMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQ 385
F E++ + +L IS + LNFT+N L L+ L++
Sbjct: 562 -FEELHKLEVLDISSNSHYFQ----SEGITHMLNFTKN------------LKVLQKLMMN 604
Query: 386 KNGLKDLFKVGLMTKDMPSLEI----LDVSWNSLESGRHK--ENCTWVESIVVLNLSSNM 439
N + + ++ + +LE LDV W ++ + +N +E + + S +
Sbjct: 605 DNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSF 664
Query: 440 LTDSVFRCLPPRIKVLDLHSNKIKSVP-KQVVKLEALQELNVAFNSLTDLPGCGSFSSLS 498
L VF +PP +K L L N +KS K++ L+ L+ L+++ N LT +P S S S
Sbjct: 665 LPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRS 724
Query: 499 V--LIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQ------------------------ 532
+ LI+ +N + + F Q ++R + N Q
Sbjct: 725 LKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNR 784
Query: 533 --CTCELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPL--KDFHMSELSC-NITLL 587
CTC+ FV ++ + D C P +++G + D + EL N+ L
Sbjct: 785 FLCTCDAVWFVWWVNHTEVTIPYLATD-VTCVGPGAHKGQSVISLDLYTCELDLTNLILF 843
Query: 588 IVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQ----FH 643
++I ++ ++ + S + D+ WY+ C+ ++ QR + +
Sbjct: 844 SLSISVSLFLMVMMTASHLYFWDV-WYIYHFCK----------AKIKGYQRLISPDCCYD 892
Query: 644 AFISYSEHDSA---WVKSELVPYLE---KEDIQICLHERNFVPGKSIVENIINCIEKSYK 697
AFI Y D A WV +ELV LE ++ +CL ER+++PG+ ++EN+ I+ S K
Sbjct: 893 AFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKK 952
Query: 698 SIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQ 757
++FV++ + ++E Y +H L E + +ILI LE Q S K+ +L+ +
Sbjct: 953 TVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKS---KFLQLRKRLCG 1009
Query: 758 RTYLQWPKEKSKRGLFWANIRAAFNMKLTLVTENN 792
+ L+WP FW ++ A L T+N+
Sbjct: 1010 SSVLEWPTNPQAHPYFWQCLKNA------LATDNH 1038
Score = 38.5 bits (88), Expect = 0.025
Identities = 26/59 (44%), Positives = 36/59 (61%), Gaps = 1/59 (1%)
Query: 55 KVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRI-QLLDLSVFKFNQDLEYLDLSHNQL 112
+ LD+S+N I ++ SD LS L L LS N I Q L+ S F+ +L YLD S+N+L
Sbjct: 496 QTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRL 554
Score = 37.7 bits (86), Expect = 0.042
Identities = 27/108 (25%), Positives = 50/108 (46%), Gaps = 7/108 (6%)
Query: 36 VDKSKRGLIHVPKD----LPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLL 91
+D SK L +P +P K L +++N + + L L L LSHN++ +
Sbjct: 655 LDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTV 714
Query: 92 DLSVFKFNQDLEYLDLSHNQLQKIS---CHPIVSFRHLDLSFNDFKAL 136
+ ++ L+ L L +NQ++ ++ R+LDLS N + +
Sbjct: 715 PERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMI 762
Score = 36.6 bits (83), Expect = 0.094
Identities = 23/57 (40%), Positives = 34/57 (59%), Gaps = 1/57 (1%)
Query: 55 KVLDMSQNYIAE-LQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHN 110
K L++S N I++ L S+ L+EL L S+NR+ LL + F+ LE LD+S N
Sbjct: 520 KCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSN 576
Score = 32.7 bits (73), Expect = 1.4
Identities = 44/177 (24%), Positives = 77/177 (43%), Gaps = 33/177 (18%)
Query: 376 LVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNL 435
L KL+ L L+ N + + V +PS +N++ + +++ + + +L+L
Sbjct: 203 LTKLKVLSLKDNNVTAVPTV------LPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDL 256
Query: 436 SSNM--LTDSVFRCLPPR-----------------IKVLDLHSNKIKSVPKQVVK-LEAL 475
S N ++ F C P + +KVL LHSN ++ VP + K + L
Sbjct: 257 SGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKL 316
Query: 476 QELNVAFNSLTDLPGCGSF----SSLSVLIIDHN---SVSHPSADFFQSCQKMRSIK 525
QEL+++ N L G F SL L + N V S + Q+ ++S+K
Sbjct: 317 QELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLK 373
>gi|16751843 toll-like receptor 5 [Homo sapiens]
Length = 858
Score = 130 bits (326), Expect = 6e-30
Identities = 190/818 (23%), Positives = 350/818 (42%), Gaps = 114/818 (13%)
Query: 43 LIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQL-LDLSVFKFNQD 101
L VP+ L ++L +S NYI + S FL +L +L L L +D F+ +
Sbjct: 38 LTQVPQVLNTTERLL-LSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPN 96
Query: 102 LEYLDLSHNQLQKISCHP-------------------------------IVSFRHLDLSF 130
L LDL +++ + HP + + LDLS
Sbjct: 97 LRILDLGSSKIYFL--HPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSK 154
Query: 131 NDFKALPICKEFGNLSQLNFLGLSAMKLQKL---DLLPIAHLHLSYILLDLRNYYIKEN- 186
N ++L + FG L+ L + S+ ++ + +L P+ LS+ L + Y + +
Sbjct: 155 NQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSV 214
Query: 187 ---------ETESLQILNAKTLHLVFHPTSLF--------AIQVNISVNTLGC-LQLTNI 228
L+IL+ T F A + ++ + +G NI
Sbjct: 215 DWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNI 274
Query: 229 KLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNI-YNLT 287
K D N + L R S++ + L+H + RVF+ L K ++ LN+ YN
Sbjct: 275 KDPDQNT------FAGLAR-SSVRHLDLSH-GFVFSLNSRVFETL--KDLKVLNLAYNK- 323
Query: 288 IIESIREEDFTYSKTTLKALTIEH-----ITNQVFLFSQTALYTVFSEMNIMMLTISDTP 342
I I +E F Y L+ L + + + + F Y + +I ++
Sbjct: 324 -INKIADEAF-YGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFK 381
Query: 343 FIHMLCP-----HAPSTFKFLNFTQNVFTDSIFEKCSTLVKLET----LILQKNGLKDLF 393
F+ L +A +T F+ ++F K TL K+ + L +N L++L
Sbjct: 382 FLEKLQTLDLRDNALTTIHFIPSIPDIFLSG--NKLVTLPKINLTANLIHLSENRLENLD 439
Query: 394 KVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDS--------VF 445
+ + + +P L+IL ++ N S + + S+ L L NML + VF
Sbjct: 440 ILYFLLR-VPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVF 498
Query: 446 RCLPPRIKVLDLHSNKIKSVPKQVVK-LEALQELNVAFNSLTDLPGCGSFSSLSVLIIDH 504
L ++VL L+ N + S+P V L AL+ L++ N LT L ++L +L I
Sbjct: 499 EGLS-HLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISR 557
Query: 505 NSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSYKCDYP 564
N + P+ D F S + + N F C CEL F+ ++ ++ + G P C YP
Sbjct: 558 NQLLAPNPDVFVS---LSVLDITHNKFICECELSTFINWLNH-TNVTIAGPPADIYCVYP 613
Query: 565 ESYRGSPLKDFHMSELSCNITLLIVTIGATM-LVLAVTVTSLCIYLDLPWYLR---MVCQ 620
+S+ G L F +S C+ ++ ++ ++ +V VT+T + + R +C
Sbjct: 614 DSFSGVSL--FSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICY 671
Query: 621 WTQTRRRARNIPLEELQRNLQFHAFISYSEHDSAWVKSELVPYLEKE-----DIQICLHE 675
T R ++ P ++ A++ +S D WV++ L+ +L+ + +C E
Sbjct: 672 KTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEE 731
Query: 676 RNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHNLFHEGSNNLILIL 735
R+FVPG++ + NI + I S K + ++S +F++ WC +A + ++ LI+++
Sbjct: 732 RDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVV 791
Query: 736 LEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLF 773
+ + Q + K+ ++ + ++ YL+WP++ G F
Sbjct: 792 VGSLSQYQL-MKHQSIRGFVQKQQYLRWPEDLQDVGWF 828
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 108 bits (270), Expect = 2e-23
Identities = 189/778 (24%), Positives = 328/778 (42%), Gaps = 96/778 (12%)
Query: 63 YIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKI-----SC 117
+ +L S LS L L L + + L+ S F+ +L LDLS N L K +
Sbjct: 271 HFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAF 330
Query: 118 HPIVSFRHLDLSFN-----DFKALPICKEFGNLSQLNFLGLSAMKLQKLD---LLPIAHL 169
+ R L+LSFN F L + FG+L L L + + + LD L P+A L
Sbjct: 331 QGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARL 390
Query: 170 HLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTL-GCLQLTNI 228
+ L N+ N+ + L I A P + V++S N + G +LT
Sbjct: 391 PMLQTLRLQMNFI---NQAQ-LGIFRA-------FPGLRY---VDLSDNRISGASELTAT 436
Query: 229 KLNDDNCQ-------------VFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWP 275
D + V + + LNFTL+ + V+ F
Sbjct: 437 MGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLD-LSRNNLVTVQPEMFAQL 495
Query: 276 KPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMM 335
++ L + + I +++ F T L+ L + H N++ L+ + + +T + +
Sbjct: 496 SHLQCLRLSHNCISQAVNGSQFL-PLTGLQVLDLSH--NKLDLYHEHS-FTELPRLEALD 551
Query: 336 LTISDTPFIHMLCPHAPS------TFKFLNFTQNVFTDSIFEK-CSTLVKLETLILQKNG 388
L+ + PF H S T + L+ N + ++ CST L L N
Sbjct: 552 LSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCST--SLRALDFSGNA 609
Query: 389 LKDLFKVGLMT----KDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSV 444
L ++ G + + + L LD+S N L + + +S+ VL L N L
Sbjct: 610 LGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFK 669
Query: 445 FRCLP--PRIKVLDLHSNKIKSVPKQVVKLEA-LQELNVAFNSLTDL-PGCGSFSS-LSV 499
+ L P+++VLDL N++K++ + L+ L+V+ NS++ + PG S + L
Sbjct: 670 WWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRE 729
Query: 500 LIIDHNSVSHPSADFFQS-CQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDS 558
L + N++ +F ++ + NP C C F+ + +V + V G P
Sbjct: 730 LNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAA-FMDFLLEVQAAV-PGLPSR 787
Query: 559 YKCDYPESYRGSPL--------KDFHMSELSCNITLLIVTIGATMLVLAVTVTSLCIYLD 610
KC P +G + D +S ++LL V +G + +L LC + D
Sbjct: 788 VKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLH----HLCGW-D 842
Query: 611 LPWYLRMVC-QWTQTRRRARNIPLEELQRNLQFHAFISYSEHDSA---WVKSELVPYLE- 665
L WY +C W R R + L + AF+ + + SA WV +EL LE
Sbjct: 843 L-WYCFHLCLAWLPWRGRQSGRDEDALP----YDAFVVFDKTQSAVADWVYNELRGQLEE 897
Query: 666 ---KEDIQICLHERNFVPGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHN 722
+ +++CL ER+++PGK++ EN+ + S K++FVL+ S A
Sbjct: 898 CRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQR 957
Query: 723 LFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYLQWPKEKSKRGLFWANIRAA 780
L + + ++L++L P + S +Y +L+ + +++ L WP + S + FWA + A
Sbjct: 958 LLEDRKDVVVLVILSPDGRRS---RYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMA 1012
Score = 43.9 bits (102), Expect = 6e-04
Identities = 32/79 (40%), Positives = 42/79 (53%), Gaps = 4/79 (5%)
Query: 57 LDMSQNYIAELQVSDMSFLSELTVLRLSHNRI-QLLDLSVFKFNQDLEYLDLSHNQLQKI 115
LD+S+N + +Q + LS L LRLSHN I Q ++ S F L+ LDLSHN+L
Sbjct: 477 LDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLY 536
Query: 116 SCHPIVS---FRHLDLSFN 131
H LDLS+N
Sbjct: 537 HEHSFTELPRLEALDLSYN 555
Score = 37.4 bits (85), Expect = 0.055
Identities = 35/115 (30%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 48 KDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDL 107
++LP +VL + NY+A + + FL +L VL L+ N+++ L L LD+
Sbjct: 649 RNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDV 708
Query: 108 SHNQLQKIS---CHPIVSFRHLDLSFNDFKALPICKEFGNL-SQLNFLGLSAMKL 158
S N + ++ R L+LS N K + FG L S L L +SA L
Sbjct: 709 SCNSISFVAPGFFSKAKELRELNLSANALKTVD-HSWFGPLASALQILDVSANPL 762
Score = 33.9 bits (76), Expect = 0.61
Identities = 36/118 (30%), Positives = 51/118 (43%), Gaps = 15/118 (12%)
Query: 78 LTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALP 137
+T L LS NRI L S F L +L+L N + P+ H+ + + F A+P
Sbjct: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWN-CPPVGLSPMHFPCHMTIEPSTFLAVP 123
Query: 138 ICKEFGNLSQLNF------------LGLSAMKLQKLDLLPIAHLH-LSYILLDLRNYY 182
+E NLS N L LS + LD +A LH L ++ +D YY
Sbjct: 124 TLEEL-NLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
Score = 30.0 bits (66), Expect = 8.8
Identities = 21/65 (32%), Positives = 31/65 (47%), Gaps = 3/65 (4%)
Query: 55 KVLDMSQNYIAELQVSDMSFLSELTVL---RLSHNRIQLLDLSVFKFNQDLEYLDLSHNQ 111
K LDM + L + + L+ L +L RL N I L +F+ L Y+DLS N+
Sbjct: 367 KELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNR 426
Query: 112 LQKIS 116
+ S
Sbjct: 427 ISGAS 431
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 73.2 bits (178), Expect = 9e-13
Identities = 122/514 (23%), Positives = 212/514 (41%), Gaps = 101/514 (19%)
Query: 32 NEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQV--SDMSFLSELTVLRLSHNRIQ 89
N +D SKR + +P + T++ ++ Y +LQ +++ L L L LS N +
Sbjct: 101 NSMRLDLSKRSIHILPSSIKELTQLTELYL-YSNKLQSLPAEVGCLVNLMTLALSENSLT 159
Query: 90 LLDLSVFKFNQDLEYLDLSHNQLQKISC--HPIVSFRHLDLSFNDFKALPICKEFGNLSQ 147
L S+ + L LDL HN+L++I + + S L L FN + + K+ NLS+
Sbjct: 160 SLPDSLDNLKK-LRMLDLRHNKLREIPSVVYRLDSLTTLYLRFN--RITTVEKDIKNLSK 216
Query: 148 LNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTS 207
L+ +L +R IK+ E ++ N TL + +
Sbjct: 217 LS-------------------------MLSIRENKIKQLPAEIGELCNLITLDVAHNQLE 251
Query: 208 LFAIQVNISVNTLGCLQLTNIKLNDDNCQVF---IKFLSELTRGSTLLNFTLNHIETTWK 264
++ C Q+TN+ L + I LS L+R L N + +
Sbjct: 252 HLPKEIG------NCTQITNLDLQHNELLDLPDTIGNLSSLSR----LGLRYNRLSAIPR 301
Query: 265 CLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTAL 324
L + +E LN+ N I S E S L +LT+ Q++ +
Sbjct: 302 SLAKC------SALEELNLENNNI--STLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQ 353
Query: 325 YTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLIL 384
++ +N+ I+ PF IF + L KL +
Sbjct: 354 FSTIYSLNMEHNRINKIPF------------------------GIFSRAKVLSKLN---M 386
Query: 385 QKNGLKDL-FKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDS 443
+ N L L G T S+ L+++ N L + E+ + + S+ VL LS+N+L
Sbjct: 387 KDNQLTSLPLDFGTWT----SMVELNLATNQLT--KIPEDVSGLVSLEVLILSNNLL--- 437
Query: 444 VFRCLPP------RIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLP-GCGSFSS 496
+ LP +++ LDL NK++S+P ++ L+ LQ+L + N LT LP G G ++
Sbjct: 438 --KKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTN 495
Query: 497 LSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNP 530
L+ L + N ++H + + + + + DNP
Sbjct: 496 LTHLGLGENLLTHLPEE-IGTLENLEELYLNDNP 528
Score = 32.0 bits (71), Expect = 2.3
Identities = 26/105 (24%), Positives = 45/105 (42%), Gaps = 5/105 (4%)
Query: 446 RCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPG-CGSFSSLSVLIIDH 504
+C LDL I +P + +L L EL + N L LP G +L L +
Sbjct: 96 KCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSE 155
Query: 505 NSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSS 549
NS++ D + +K+R + N + E+ V +D +++
Sbjct: 156 NSLT-SLPDSLDNLKKLRMLDLRHNKLR---EIPSVVYRLDSLTT 196
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 73.2 bits (178), Expect = 9e-13
Identities = 113/442 (25%), Positives = 177/442 (40%), Gaps = 80/442 (18%)
Query: 30 DGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQ 89
DG + D S+ GL VP DL T LD+S N + ELQ L L LRLS N +
Sbjct: 44 DGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLS 103
Query: 90 LLDLSVFKFNQDLEYLDLSHNQLQKI---------------------------SCHPIVS 122
+ F L+ L L +NQL I S + S
Sbjct: 104 HIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSS 163
Query: 123 FRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYY 182
RHL L N +P+ + NL L + L+ ++ + +L S ++L L N
Sbjct: 164 LRHLWLDDNALTEIPV-RALNNLPALQAMTLALNRISHIPDYAFQNL-TSLVVLHLHNNR 221
Query: 183 IKENETESLQIL-NAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKF 241
I+ T S + L N +TL L ++ F +++ TLG LQ N+ IK
Sbjct: 222 IQHLGTHSFEGLHNLETLDLNYNKLQEFP----VAIRTLGRLQELGFHNNN------IKA 271
Query: 242 LSELTRGSTLLNFTLNHIETTWKCLVR-VFQFLWPKPVEYLNIYNLTIIESIREEDFTYS 300
+ E L T++ + + + R FQ+L PK L+ +L I+E
Sbjct: 272 IPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL-PK----LHTLSLNGAMDIQEFPDLKG 326
Query: 301 KTTLKALTIEHITNQVFLFSQTALYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNF 360
T+L+ LT+ ++ + + I + P +H
Sbjct: 327 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLH--------------- 371
Query: 361 TQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMT-KDMPSLEILDVSWNSLESGR 419
+C KLE + LQ N ++++G T + SL+ LD+SWN++ S
Sbjct: 372 -----------RCQ---KLEEIGLQHN---RIWEIGADTFSQLSSLQALDLSWNAIRS-I 413
Query: 420 HKENCTWVESIVVLNLSSNMLT 441
H E + + S+V L+L+ N LT
Sbjct: 414 HPEAFSTLHSLVKLDLTDNQLT 435
Score = 48.1 bits (113), Expect = 3e-05
Identities = 75/318 (23%), Positives = 131/318 (41%), Gaps = 46/318 (14%)
Query: 55 KVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQK 114
+ + ++ N I+ + L+ L VL L +NRIQ L F+ +LE LDL++N+LQ+
Sbjct: 189 QAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQE 248
Query: 115 --ISCHPIVSFRHLDLSFNDFKALPICKEFGNL---------SQLNFLGLSAMKLQKLDL 163
++ + + L N+ KA+P GN + + F+G SA +
Sbjct: 249 FPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQY----- 303
Query: 164 LPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCL 223
LP H +D++ + + T SL+IL + P+ + C
Sbjct: 304 LPKLHTLSLNGAMDIQEFPDLKGTT-SLEILTLTRAGIRLLPSGM-------------CQ 349
Query: 224 QLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFLWPKPVEYLNI 283
QL +++ + + I+ L L R L L H W+ F L ++ L++
Sbjct: 350 QLPRLRVLELSHNQ-IEELPSLHRCQKLEEIGLQH-NRIWEIGADTFSQL--SSLQALDL 405
Query: 284 YNLTIIESIREEDFTYSKTTLKA-LTIEHITN----------QVFLFSQTALYTVFSEMN 332
+ I SI E F+ + +K LT +T + L AL FS+ +
Sbjct: 406 -SWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDS 464
Query: 333 IMMLTISDTPFIHMLCPH 350
L I + P+ + CP+
Sbjct: 465 FPKLRILEVPYAYQCCPY 482
Score = 35.8 bits (81), Expect = 0.16
Identities = 25/79 (31%), Positives = 34/79 (43%)
Query: 53 KTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQL 112
K + + + N I E+ S LS L L LS N I+ + F L LDL+ NQL
Sbjct: 375 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQL 434
Query: 113 QKISCHPIVSFRHLDLSFN 131
+ + HL L N
Sbjct: 435 TTLPLAGLGGLMHLKLKGN 453
Score = 33.9 bits (76), Expect = 0.61
Identities = 26/100 (26%), Positives = 50/100 (50%), Gaps = 12/100 (12%)
Query: 440 LTDSVFRCLP-------PRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCG 492
LT + R LP PR++VL+L N+I+ +P + + + L+E+ + N + ++ G
Sbjct: 335 LTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP-SLHRCQKLEEIGLQHNRIWEI-GAD 392
Query: 493 SF---SSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDN 529
+F SSL L + N++ + F + + + DN
Sbjct: 393 TFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 432
Score = 31.2 bits (69), Expect = 4.0
Identities = 33/119 (27%), Positives = 58/119 (48%), Gaps = 11/119 (9%)
Query: 376 LVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTW--VESIVVL 433
L L L L N L ++ L ++P+L+ + ++ N + H + + + S+VVL
Sbjct: 161 LSSLRHLWLDDNALTEIPVRAL--NNLPALQAMTLALNRIS---HIPDYAFQNLTSLVVL 215
Query: 434 NLSSNM---LTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLP 489
+L +N L F L ++ LDL+ NK++ P + L LQEL N++ +P
Sbjct: 216 HLHNNRIQHLGTHSFEGLH-NLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIP 273
>gi|4504661 interleukin 1 receptor accessory protein isoform 1 [Homo
sapiens]
Length = 570
Score = 69.3 bits (168), Expect = 1e-11
Identities = 70/265 (26%), Positives = 124/265 (46%), Gaps = 41/265 (15%)
Query: 536 ELREFVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDFHMS----------ELSCNIT 585
E R + +I +V+SE L+ SY C + S +G K + EL+C
Sbjct: 310 ETRTQILSIKKVTSEDLKR---SYVC-HARSAKGEVAKAAKVKQKVPAPRYTVELACGF- 364
Query: 586 LLIVTIGATMLVLAVTVTSLCIYLDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAF 645
GAT+L++ + + +Y +L MV + RA E + ++ +
Sbjct: 365 ------GATVLLVVILIVVYHVY-----WLEMVLFY-----RAHFGTDETILDGKEYDIY 408
Query: 646 ISYSEH--DSAWVKSELVPYLEKE-DIQICLHERNFVPGKSIVENIINCIEKSYKSIFVL 702
+SY+ + + +V L LE E ++C+ +R+ +PG + + ++ I+KS + + VL
Sbjct: 409 VSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVL 468
Query: 703 SPNFV-QSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQNSIPNKYHKLKALMTQRTYL 761
SPN+V Q EL N+ G+ N+IL+ + + + K +LK T T +
Sbjct: 469 SPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKE----TKVKELKRAKTVLTVI 524
Query: 762 QWPKEKSK--RGLFWANIRAAFNMK 784
+W EKSK +G FW ++ A +K
Sbjct: 525 KWKGEKSKYPQGRFWKQLQVAMPVK 549
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 63.5 bits (153), Expect = 7e-10
Identities = 131/566 (23%), Positives = 209/566 (36%), Gaps = 103/566 (18%)
Query: 42 GLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQD 101
GL+ VP LP T+ LD+S N + + S + F + L L LS N I L F+
Sbjct: 39 GLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTH 98
Query: 102 LEYLDLSHNQLQKISC------HPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSA 155
LE+L L+HN+L + P+ LDLS N + + + G L+ L L+
Sbjct: 99 LEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAE 158
Query: 156 MKLQKL------DLLPIAHLHL-SYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSL 208
L +L D+ + L L S +L+D I++ E L L
Sbjct: 159 NSLTRLTRHTFRDMPALEQLDLHSNVLMD-----IEDGAFEGLPRLT------------- 200
Query: 209 FAIQVNISVNTLGCL---QLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKC 265
+N+S N+L C+ L +++ D +C F T F L ++
Sbjct: 201 ---HLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAF---QTASQPQAEFQLTWLDLRENK 254
Query: 266 LVRVFQFLWPKPVEYLNIYNLTI------------------------------------I 289
L+ + YLN+ N I +
Sbjct: 255 LLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPL 314
Query: 290 ESIREEDFTYSKTTL-KALTIEHITNQVFL-FSQTALYT-----VFSEMNIMMLTISDTP 342
+ D +Y++ L +EH+T+ FL S+ L T + S +M+L +S
Sbjct: 315 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNA 374
Query: 343 FIHM-LCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKN------GLKDLFKV 395
+ L A + + L N D + L L+ L LQ N G +
Sbjct: 375 LETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 434
Query: 396 GLMT----KDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSN---MLTDSVFRCL 448
G + + SL ++D L +G + L+LSSN + L
Sbjct: 435 GCVAFSGITSLRSLSLVDNEIELLRAGAFLHT-----PLTELDLSSNPGLEVATGALGGL 489
Query: 449 PPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVS 508
++VL L N + + + L+ LN+A N L+ LP SL VL + +NS S
Sbjct: 490 EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFS 549
Query: 509 -HPSADFFQSCQKMRSIKAGDNPFQC 533
P + +R + NP C
Sbjct: 550 LLPGSAMGGLETSLRRLYLQGNPLSC 575
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 63.5 bits (153), Expect = 7e-10
Identities = 131/566 (23%), Positives = 209/566 (36%), Gaps = 103/566 (18%)
Query: 42 GLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQD 101
GL+ VP LP T+ LD+S N + + S + F + L L LS N I L F+
Sbjct: 39 GLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTH 98
Query: 102 LEYLDLSHNQLQKISC------HPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSA 155
LE+L L+HN+L + P+ LDLS N + + + G L+ L L+
Sbjct: 99 LEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLHTLSLAE 158
Query: 156 MKLQKL------DLLPIAHLHL-SYILLDLRNYYIKENETESLQILNAKTLHLVFHPTSL 208
L +L D+ + L L S +L+D I++ E L L
Sbjct: 159 NSLTRLTRHTFRDMPALEQLDLHSNVLMD-----IEDGAFEGLPRLT------------- 200
Query: 209 FAIQVNISVNTLGCL---QLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKC 265
+N+S N+L C+ L +++ D +C F T F L ++
Sbjct: 201 ---HLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAF---QTASQPQAEFQLTWLDLRENK 254
Query: 266 LVRVFQFLWPKPVEYLNIYNLTI------------------------------------I 289
L+ + YLN+ N I +
Sbjct: 255 LLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPL 314
Query: 290 ESIREEDFTYSKTTL-KALTIEHITNQVFL-FSQTALYT-----VFSEMNIMMLTISDTP 342
+ D +Y++ L +EH+T+ FL S+ L T + S +M+L +S
Sbjct: 315 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNA 374
Query: 343 FIHM-LCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLILQKN------GLKDLFKV 395
+ L A + + L N D + L L+ L LQ N G +
Sbjct: 375 LETLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPS 434
Query: 396 GLMT----KDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSN---MLTDSVFRCL 448
G + + SL ++D L +G + L+LSSN + L
Sbjct: 435 GCVAFSGITSLRSLSLVDNEIELLRAGAFLHT-----PLTELDLSSNPGLEVATGALGGL 489
Query: 449 PPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVS 508
++VL L N + + + L+ LN+A N L+ LP SL VL + +NS S
Sbjct: 490 EASLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFS 549
Query: 509 -HPSADFFQSCQKMRSIKAGDNPFQC 533
P + +R + NP C
Sbjct: 550 LLPGSAMGGLETSLRRLYLQGNPLSC 575
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 62.8 bits (151), Expect = 1e-09
Identities = 116/500 (23%), Positives = 209/500 (41%), Gaps = 71/500 (14%)
Query: 50 LPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSH 109
LP T VLD+ N + L S + L L L +SHN++++L + ++L+ L L H
Sbjct: 104 LPALT-VLDIHDNQLTSLP-SAIRELENLQKLNVSHNKLKILPEEITNL-RNLKCLYLQH 160
Query: 110 NQLQKIS--CHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLD----- 162
N+L IS + + LDLS N +P F +LS L L LS+ +L+ L
Sbjct: 161 NELTCISEGFEQLSNLEDLDLSNNHLTTVPA--SFSSLSSLVRLNLSSNELKSLPAEINR 218
Query: 163 LLPIAHLHLSYILLDLRNYYIKENET-ESLQILNAKTLHLVFHPTSLFAIQVNISVNTLG 221
+ + HL + LL+ + E+ E L + K L P+ ++++ N +
Sbjct: 219 MKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIE 278
Query: 222 CLQLTNIK-LND-------DNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQFL 273
L+ ++K LN DN + L R L+ + N I + L +
Sbjct: 279 MLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISSLPYSLGNLHLKF 338
Query: 274 WPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTALYTVFSEMNI 333
L II +E Y ++ +K + +Q ++TA+ T+ SE +
Sbjct: 339 LALEGNPLRTIRREIISKGTQEVLKYLRSKIK----DDGPSQSESATETAM-TLPSESRV 393
Query: 334 MMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFT---DSIFEKCSTLVKLETLILQKNGLK 390
+ HA T K L+++ T D +F+ + + + ++ KN L
Sbjct: 394 NI--------------HAIITLKILDYSDKQATLIPDEVFDAVKSNI-VTSINFSKNQLC 438
Query: 391 DLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPP 450
++ K + K+M S +D+S+N L S + L L C+
Sbjct: 439 EIPKRMVELKEMVS--DVDLSFNKL-------------SFISLEL-----------CVLQ 472
Query: 451 RIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPG-CGSFSSLSVLIIDHNSVSH 509
++ LDL +N + S+P+++ L LQ +N++FN LP +L ++I +N V
Sbjct: 473 KLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEVLYRIFTLETILISNNQVGS 532
Query: 510 PSADFFQSCQKMRSIKAGDN 529
+ + + ++ +N
Sbjct: 533 VDPQKMKMMENLTTLDLQNN 552
Score = 50.8 bits (120), Expect = 5e-06
Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 6/117 (5%)
Query: 401 DMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSN 460
D+P ++S+ + E + + T +++ N LTD + L P + VLD+H N
Sbjct: 61 DIPEEANQNLSFGATERWWEQTDLT---KLIISNNKLQSLTDDLR--LLPALTVLDIHDN 115
Query: 461 KIKSVPKQVVKLEALQELNVAFNSLTDLP-GCGSFSSLSVLIIDHNSVSHPSADFFQ 516
++ S+P + +LE LQ+LNV+ N L LP + +L L + HN ++ S F Q
Sbjct: 116 QLTSLPSAIRELENLQKLNVSHNKLKILPEEITNLRNLKCLYLQHNELTCISEGFEQ 172
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 62.0 bits (149), Expect = 2e-09
Identities = 131/551 (23%), Positives = 217/551 (39%), Gaps = 74/551 (13%)
Query: 32 NEFAVDKSKRGLIHVPKD-LPLK-TKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQ 89
+ F V+ +GL PKD L +K K L + +N I Q +D L L +L L N +
Sbjct: 142 DNFTVNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLS 201
Query: 90 LLDLSVFKFNQDLEYLDLSHNQLQKI--SCHPIVSFRHLDLSFNDFKALPICKEFGNLSQ 147
L S + +L L++SHN + I + + R L N + P + L
Sbjct: 202 SLP-SEIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFP--SDLECLGN 258
Query: 148 LNFLGLSAMKLQKL-DLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFHPT 206
L L L KL+ + D LP ++L++LN + L P
Sbjct: 259 LEILSLGKNKLRHIPDTLP---------------------SLKTLRVLNLEYNQLTTFPK 297
Query: 207 SLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCL 266
+L + IS++ G L K + EL TLL ++H + T+
Sbjct: 298 ALCFLPKLISLDLTGNL-----------ISSLPKEIRELKNLETLL---MDHNKLTFLA- 342
Query: 267 VRVFQFLWPKPVEYLNIYNLTI---IESIREEDFTYSKTTLKALTIEHITNQVFLFSQTA 323
V +FQ L K ++ + I IE+ RE L E I+ L +
Sbjct: 343 VEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSL 402
Query: 324 LYTVFSEM--------NIMMLTISDTPFIHML-CPHAPSTFKFLNFTQNVFTDSIFE--K 372
+E+ N+ L ++ + + C + L F+ N+ TD E
Sbjct: 403 SDNKLTELPKYIHKLNNLRKLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKN 462
Query: 373 CSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVV 432
C ++K+E L N + F +GL D SL L V+ N + + ++ + ++
Sbjct: 463 CQKIIKIE---LSYNKIM-YFPLGLCALD--SLYYLSVNGNYISE--IPVDISFSKQLLH 514
Query: 433 LNLSSN-MLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLP-G 490
L LS N +L S C +K LDL N+IK +P + + +L L + N P
Sbjct: 515 LELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPRE 574
Query: 491 CGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQC----TCELREFVK-NID 545
+ +L VL + N + S+D + + ++ + N F C+L+ + NI
Sbjct: 575 LCTLENLQVLDLSENQLQKISSDIC-NLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
Query: 546 QVSSEVLEGWP 556
Q+ L P
Sbjct: 634 QIKGRKLTRLP 644
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/185 (31%), Positives = 93/185 (50%), Gaps = 18/185 (9%)
Query: 52 LKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQ 111
+ K LD+ +N I ++ S + +S L VL L N+ + + ++L+ LDLS NQ
Sbjct: 533 INLKYLDLGKNQIKKIPASISNMIS-LHVLILCCNKFETFPRELCTL-ENLQVLDLSENQ 590
Query: 112 LQKIS---CHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAH 168
LQKIS C+ + + L+ S N F PI E L L L +S +K +KL LP
Sbjct: 591 LQKISSDICN-LKGIQKLNFSSNQFIHFPI--ELCQLQSLEQLNISQIKGRKLTRLPGEL 647
Query: 169 LHLSYIL-LDLRNYYIKE-----NETESLQILNAKTLHLVFHPTSLFAI----QVNISVN 218
+++ + LD+ N I+E E +L L+A + + P SL ++ Q+N+S N
Sbjct: 648 SNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLSLNDLQQLNLSGN 707
Query: 219 TLGCL 223
L L
Sbjct: 708 NLTAL 712
Score = 55.8 bits (133), Expect = 1e-07
Identities = 127/549 (23%), Positives = 225/549 (40%), Gaps = 91/549 (16%)
Query: 39 SKRGLIHVPKDLPLKTKV--LDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVF 96
S + H+PK++ + L NYI SD+ L L +L L N+++ + ++
Sbjct: 219 SHNHISHIPKEISQLGNIRQLFFYNNYIENFP-SDLECLGNLEILSLGKNKLRHIPDTLP 277
Query: 97 KFNQDLEYLDLSHNQLQ---KISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGL 153
+ L L+L +NQL K C + LDL+ N +LP KE L L L
Sbjct: 278 SL-KTLRVLNLEYNQLTTFPKALCF-LPKLISLDLTGNLISSLP--KEIRELKNLETL-- 331
Query: 154 SAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENETE--SLQILNAKTLHLVFHPTSLFAI 211
M KL L + + LL ++ + +N+ E S +I N + L ++ +L
Sbjct: 332 -LMDHNKLTFLAVE----IFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLK- 385
Query: 212 QVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTWKCLVRVFQ 271
NI C L + L+D+ K++ +L L+ N++ C+ +
Sbjct: 386 --NIPEKISCCAMLECLSLSDNKLTELPKYIHKLNN-LRKLHVNRNNMVKITDCISHLNN 442
Query: 272 F---------LWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKAL-TIEHITNQVFLFSQ 321
+ P+E N + IE + Y L AL ++ +++ S+
Sbjct: 443 ICSLEFSGNIITDVPIEIKNCQKIIKIE-LSYNKIMYFPLGLCALDSLYYLSVNGNYISE 501
Query: 322 TALYTVFSEMNIMMLTISDTPFIHMLCPHAPS--TFKFLNFTQNVFTDSIFEKCSTLVKL 379
+ FS+ ++ L +S+ + + H S K+L+ +N I S ++ L
Sbjct: 502 IPVDISFSKQ-LLHLELSENKLL-IFSEHFCSLINLKYLDLGKNQIK-KIPASISNMISL 558
Query: 380 ETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLES---------GRHKENCT----- 425
LIL N + F L T + +L++LD+S N L+ G K N +
Sbjct: 559 HVLILCCNKF-ETFPRELCT--LENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFI 615
Query: 426 -------WVESIVVLNLS--------------SNM-------LTDSVFRCLPPRI----K 453
++S+ LN+S SNM ++++ R +P I
Sbjct: 616 HFPIELCQLQSLEQLNISQIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRN 675
Query: 454 VLDLHS--NKIKSVPKQVVKLEALQELNVAFNSLTDLPGC-GSFSSLSVLIIDHNSVSHP 510
++ LH+ N+I +P ++ L LQ+LN++ N+LT LP + SL + D N + P
Sbjct: 676 LVSLHAYNNQISYLPPSLLSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRP 735
Query: 511 SADFFQSCQ 519
+ + Q
Sbjct: 736 PVEICKGKQ 744
>gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
Length = 541
Score = 61.2 bits (147), Expect = 4e-09
Identities = 74/259 (28%), Positives = 117/259 (45%), Gaps = 48/259 (18%)
Query: 541 VKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLKDF------HMSELSCNITLLIVTIGAT 594
++NI + + VL Y C S G+ K F M+++ ++ + I
Sbjct: 284 IENIGESNLNVL------YNCTVA-STGGTDTKSFILVRKADMADIPGHVFTRGMIIAVL 336
Query: 595 MLVLAVTVTSLCIY--LDLPWYLRMVCQWTQTRRRARNIPLEELQRNLQFHAFISY---- 648
+LV V + ++C+ +DL + R + TRR E L + AF+SY
Sbjct: 337 ILVAVVCLVTVCVIYRVDLVLFYRHL-----TRRD------ETLTDGKTYDAFVSYLKEC 385
Query: 649 -----SEHDSAWVKSELVP-YLEKE-DIQICLHERNFVPGKSIVENIINCIEKSYKSIFV 701
EH A E++P LEK ++C+ ER+ VPG ++V+ I + IEKS + I V
Sbjct: 386 RPENGEEHTFA---VEILPRVLEKHFGYKLCIFERDVVPGGAVVDEIHSLIEKSRRLIIV 442
Query: 702 LSPNFVQSEWCHYELYFAHHNLFHEGSNNLILILLEPIPQ-NSIPNKYHKLKALMTQRTY 760
LS +++ +E YEL H E +ILI P+ +P LK L + R
Sbjct: 443 LSKSYMSNE-VRYELESGLHEALVERKIKIILIEFTPVTDFTFLP---QSLKLLKSHRV- 497
Query: 761 LQWPKEK--SKRGLFWANI 777
L+W +K S FW N+
Sbjct: 498 LKWKADKSLSYNSRFWKNL 516
>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
sapiens]
Length = 370
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/148 (34%), Positives = 69/148 (46%), Gaps = 7/148 (4%)
Query: 30 DGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQ 89
D VD S GL VP D+P T+ L + N ++ L + LS L L LS+N +
Sbjct: 46 DSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQRLDLSNNFLD 105
Query: 90 LLDLSVFKFNQDLEYLDLSHNQLQKIS---CHPIVSFRHLDLSFNDFKALPICKEFGNLS 146
L S+F +L L L +N ++ + RHLDLS N LP F L
Sbjct: 106 RLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP-PGLFDGLL 164
Query: 147 QLNFLGLSAMKLQKLDLL---PIAHLHL 171
L L L + +LQ LD L P+A+L L
Sbjct: 165 ALRSLSLRSNRLQNLDRLTFEPLANLQL 192
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/154 (27%), Positives = 75/154 (48%), Gaps = 11/154 (7%)
Query: 427 VESIVVLNLSSNMLTD---SVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEAL-QELNVAF 482
+ S+ L+LS+N L S+F L + L L +N I+++ + +++ L + L+++
Sbjct: 91 LSSLQRLDLSNNFLDRLPRSIFGDLT-NLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSI 149
Query: 483 NSLTDLPGCGSFSSLSVL---IIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELRE 539
N L LP G F L L + N + + F+ ++ ++ GDNP++C C LRE
Sbjct: 150 NGLAQLPP-GLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLRE 208
Query: 540 FVKNIDQVSSEVLEGWPDSYKCDYPESYRGSPLK 573
F ++ S G D C P+ RG ++
Sbjct: 209 FKHWMEWFSYR--GGRLDQLACTLPKELRGKDMR 240
>gi|65301141 PH domain and leucine rich repeat protein
phosphatase-like [Homo sapiens]
Length = 1323
Score = 57.8 bits (138), Expect = 4e-08
Identities = 70/223 (31%), Positives = 99/223 (44%), Gaps = 24/223 (10%)
Query: 53 KTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQL 112
K +VLD+S N + E+ V +S LS L L L HN +Q L V LE LDL HN L
Sbjct: 526 KIEVLDVSYNLLTEVPVRILSSLS-LRKLMLGHNHVQNLPTLVEHI--PLEVLDLQHNAL 582
Query: 113 QKIS---CHPIVSFRHLDLSFNDFKALP-ICKEFGNLSQLNFLGLSAMKLQKLDLLPIAH 168
++ ++ R+L+ S N ++LP C +LS L L L+ L +P+
Sbjct: 583 TRLPDTLFSKALNLRYLNASANSLESLPSACTGEESLSMLQLLYLTNNLLTD-QCIPVLV 641
Query: 169 LHLSYILLDLRNYYI------KENETESLQILNAKTLHLVFHPT---------SLFAIQV 213
HL +L L N + K N+ E L+ LN L PT +L A
Sbjct: 642 GHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIANCKRLHTLVAHSN 701
Query: 214 NISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLLNFTL 256
NIS+ LQL I+ D +C + L +TL + L
Sbjct: 702 NISIFP-EILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDL 743
Score = 53.9 bits (128), Expect = 6e-07
Identities = 120/498 (24%), Positives = 205/498 (41%), Gaps = 120/498 (24%)
Query: 63 YIAELQVSDMSFLSELTVLRLSHNRIQL-----LDLSVFKFNQDLEYLDLSHNQLQ--KI 115
Y E + + ++T L L HN +QL LD +++KF+Q L+ L+LSHN+L I
Sbjct: 259 YSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLD-TLYKFSQ-LKGLNLSHNKLGLFPI 316
Query: 116 SCHPIVSFRHLDLSFNDFKALP-----------IC----------KEFGNLSQLNFLGLS 154
I + L+LS N F LP +C +E GNL QL+ LG+S
Sbjct: 317 LLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLTTLPEELGNLQQLSSLGIS 376
Query: 155 AM----------KLQKLDLLPIAHLHLSYILLDLRNYYIKENETESLQILNAKTLHLVFH 204
KL LD + +A L + L + N + + L++ + KT+ +
Sbjct: 377 FNNFSQIPEVYEKLTMLDRVVMAGNCLEVLNLGVLNR-MNHIKHVDLRMNHLKTMVIENL 435
Query: 205 PTSLFAIQVNISVNTLGCLQLTNI-KLNDDNCQVFIKFLSELTRGSTLLNFTLNHIETTW 263
+ V++ N L L L+++ L +C R TL F+L + +
Sbjct: 436 EGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCG------RNQLRELTLSGFSLRTLYASS 489
Query: 264 KCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHITNQVFLFSQTA 323
L V + P + +L++ + ++E + D+ ++ L +
Sbjct: 490 NRLTAVNVYPVPSLLTFLDL-SRNLLECV--PDWACEAKKIEVLDVS------------- 533
Query: 324 LYTVFSEMNIMMLTISDTPFIHMLCPHAPSTFKFLNFTQNVFTDSIFEKCSTLVKLETLI 383
Y + +E+ + +L S ++ H N QN+ T + E + LE L
Sbjct: 534 -YNLLTEVPVRIL--SSLSLRKLMLGH--------NHVQNLPT--LVEH----IPLEVLD 576
Query: 384 LQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNL---SSNML 440
LQ N L L L +K + +L L+ S NSLES CT ES+ +L L ++N+L
Sbjct: 577 LQHNALTRLPDT-LFSKAL-NLRYLNASANSLES--LPSACTGEESLSMLQLLYLTNNLL 632
Query: 441 TDSVFRCLP-----------------------------PRIKVLDLHSNKIKSVPKQVVK 471
TD +C+P +++ L+L NK+K++P +
Sbjct: 633 TD---QCIPVLVGHLHLRILHLANNQLQTFPASKLNKLEQLEELNLSGNKLKTIPTTIAN 689
Query: 472 LEALQELNVAFNSLTDLP 489
+ L L N+++ P
Sbjct: 690 CKRLHTLVAHSNNISIFP 707
Score = 48.5 bits (114), Expect = 2e-05
Identities = 49/170 (28%), Positives = 78/170 (45%), Gaps = 17/170 (10%)
Query: 374 STLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVV- 432
S+L LE L +N L++L G SL L S N L + N V S++
Sbjct: 457 SSLCSLEQLHCGRNQLRELTLSGF------SLRTLYASSNRLTA----VNVYPVPSLLTF 506
Query: 433 LNLSSNMLTDSV-FRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGC 491
L+LS N+L + C +I+VLD+ N + VP +++ +L++L + N + +LP
Sbjct: 507 LDLSRNLLECVPDWACEAKKIEVLDVSYNLLTEVPVRILSSLSLRKLMLGHNHVQNLPTL 566
Query: 492 GSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDN-----PFQCTCE 536
L VL + HN+++ F +R + A N P CT E
Sbjct: 567 VEHIPLEVLDLQHNALTRLPDTLFSKALNLRYLNASANSLESLPSACTGE 616
Score = 41.2 bits (95), Expect = 0.004
Identities = 39/151 (25%), Positives = 73/151 (48%), Gaps = 13/151 (8%)
Query: 405 LEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLT-------DSVFRCLPPRIKVLDL 457
+ +D+S SLE E+ + + I LNL N + D++++ ++K L+L
Sbjct: 251 ISTVDLSCYSLEEV--PEHLFYSQDITYLNLRHNFMQLERPGGLDTLYKF--SQLKGLNL 306
Query: 458 HSNKIKSVPKQVVKLEALQELNVAFNSLTDLPG-CGSFSSLSVLIIDHNSVSHPSADFFQ 516
NK+ P + ++ L ELN++ N DLP G+ +L L +D N ++ +
Sbjct: 307 SHNKLGLFPILLCEISTLTELNLSCNGFHDLPSQIGNLLNLQTLCLDGNFLT-TLPEELG 365
Query: 517 SCQKMRSIKAGDNPFQCTCELREFVKNIDQV 547
+ Q++ S+ N F E+ E + +D+V
Sbjct: 366 NLQQLSSLGISFNNFSQIPEVYEKLTMLDRV 396
Score = 38.1 bits (87), Expect = 0.032
Identities = 79/356 (22%), Positives = 142/356 (39%), Gaps = 74/356 (20%)
Query: 55 KVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDL-SVFKFNQ------------- 100
K +D+ N++ + + ++ +T + L NR+ LDL S+ Q
Sbjct: 418 KHVDLRMNHLKTMVIENLEGNKHITHVDLRDNRLTDLDLSSLCSLEQLHCGRNQLRELTL 477
Query: 101 ---DLEYLDLSHNQLQKISCHPIVS-FRHLDLSFNDFKALP--ICK---------EFGNL 145
L L S N+L ++ +P+ S LDLS N + +P C+ + L
Sbjct: 478 SGFSLRTLYASSNRLTAVNVYPVPSLLTFLDLSRNLLECVPDWACEAKKIEVLDVSYNLL 537
Query: 146 SQLNFLGLSAMKLQKLDL-------LPIAHLHLSYILLDLRNYYIKE------NETESLQ 192
+++ LS++ L+KL L LP H+ +LDL++ + ++ +L+
Sbjct: 538 TEVPVRILSSLSLRKLMLGHNHVQNLPTLVEHIPLEVLDLQHNALTRLPDTLFSKALNLR 597
Query: 193 ILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTRGSTLL 252
LNA L P++ + S++ L L LTN L D V + L +L
Sbjct: 598 YLNASANSLESLPSACTGEE---SLSMLQLLYLTNNLLTDQCIPVLVGHLH-----LRIL 649
Query: 253 NFTLNHIETTWKCLVRVFQFLWPKPVEYLNIYNLTIIESIREEDFTYSKTTLKALTIEHI 312
+ N ++T P LN +E + E + + +K TI +
Sbjct: 650 HLANNQLQTF--------------PASKLN-----KLEQLEELNLSGNKLKTIPTTIANC 690
Query: 313 TNQVFLFSQTALYTVFSEM----NIMMLTISDTPFIHMLCPHA-PSTFKFLNFTQN 363
L + + ++F E+ I + +S +L P A P+T + L+ T N
Sbjct: 691 KRLHTLVAHSNNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGN 746
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 57.8 bits (138), Expect = 4e-08
Identities = 47/156 (30%), Positives = 78/156 (50%), Gaps = 18/156 (11%)
Query: 52 LKTKVLDMSQNYIAELQ-VSDMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHN 110
L + LD+ +N + ++ + L +LTVL+L HN I + + K LE L SHN
Sbjct: 612 LSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKLTS-LERLSFSHN 670
Query: 111 QLQKISCHPIV--SFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKL-DLLPIA 167
+++ + H + R+LDLS+ND + +P E G L L + ++ K++ L D L
Sbjct: 671 KIEVLPSHLFLCNKIRYLDLSYNDIRFIP--PEIGVLQSLQYFSITCNKVESLPDEL--- 725
Query: 168 HLHLSYILLDLRNYYIKENETESLQILNAKTLHLVF 203
Y L+ I +N SL +L+ K +L+F
Sbjct: 726 -----YFCKKLKTLKIGKN---SLSVLSPKIGNLLF 753
Score = 44.3 bits (103), Expect = 5e-04
Identities = 37/136 (27%), Positives = 69/136 (50%), Gaps = 5/136 (3%)
Query: 375 TLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLES-GRHKENCTWVESIVVL 433
+L+ L+ L L++N LK + ++ + + + L +L + NS+ H + T +E +
Sbjct: 610 SLLSLQELDLKENNLKSIEEI-VSFQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFS 668
Query: 434 NLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGS 493
+ +L +F C +I+ LDL N I+ +P ++ L++LQ ++ N + LP
Sbjct: 669 HNKIEVLPSHLFLC--NKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELY 726
Query: 494 F-SSLSVLIIDHNSVS 508
F L L I NS+S
Sbjct: 727 FCKKLKTLKIGKNSLS 742
Score = 41.2 bits (95), Expect = 0.004
Identities = 39/147 (26%), Positives = 68/147 (46%), Gaps = 15/147 (10%)
Query: 391 DLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLPP 450
DL ++ + SL+ LD+ N+L+S + + + VL L N +T +P
Sbjct: 600 DLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSIT-----YIPE 654
Query: 451 RIKV------LDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDL-PGCGSFSSLSVLIID 503
IK L NKI+ +P + ++ L++++N + + P G SL I
Sbjct: 655 HIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSIT 714
Query: 504 HNSV-SHPSADFFQSCQKMRSIKAGDN 529
N V S P +F C+K++++K G N
Sbjct: 715 CNKVESLPDELYF--CKKLKTLKIGKN 739
Score = 30.0 bits (66), Expect = 8.8
Identities = 19/58 (32%), Positives = 33/58 (56%), Gaps = 3/58 (5%)
Query: 455 LDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLPGCGSFS---SLSVLIIDHNSVSH 509
L+L ++ +P V L +LQEL++ N+L + SF L+VL + HNS+++
Sbjct: 594 LELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITY 651
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 57.4 bits (137), Expect = 5e-08
Identities = 51/169 (30%), Positives = 83/169 (49%), Gaps = 19/169 (11%)
Query: 358 LNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLES 417
LNF N + + + S+L KL+ L L N L L + +P+LE+LD+++N+L
Sbjct: 68 LNFFNNQI-EELPTQISSLQKLKHLNLGMNRLNTLPRG---FGSLPALEVLDLTYNNLSE 123
Query: 418 GRHKENCTWVESIVVLNLSSNMLTDSVFRCLPP------RIKVLDLHSNKIKSVPKQVVK 471
N ++ ++ L LS D+ F LPP ++++L L N + S+PK++ +
Sbjct: 124 NSLPGNFFYLTTLRALYLS-----DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGE 178
Query: 472 LEALQELNVAFNSLTDLP----GCGSFSSLSVLIIDHNSVSHPSADFFQ 516
L L+EL++ N LT LP V ++N P AD FQ
Sbjct: 179 LTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQ 227
Score = 51.6 bits (122), Expect = 3e-06
Identities = 39/112 (34%), Positives = 60/112 (53%), Gaps = 15/112 (13%)
Query: 430 IVVLNLSSNMLTDSVFRCLPPRI------KVLDLHSNKIKSVPKQVVKLEALQELNVAFN 483
I L LS N LT +PP I +VL+ +N+I+ +P Q+ L+ L+ LN+ N
Sbjct: 42 ITQLVLSHNKLT-----MVPPNIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMN 96
Query: 484 SLTDLP-GCGSFSSLSVLIIDHNSVSHPS--ADFFQSCQKMRSIKAGDNPFQ 532
L LP G GS +L VL + +N++S S +FF +R++ DN F+
Sbjct: 97 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFY-LTTLRALYLSDNDFE 147
>gi|34577083 ras suppressor protein 1 isoform 2 [Homo sapiens]
Length = 224
Score = 57.4 bits (137), Expect = 5e-08
Identities = 51/169 (30%), Positives = 83/169 (49%), Gaps = 19/169 (11%)
Query: 358 LNFTQNVFTDSIFEKCSTLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLES 417
LNF N + + + S+L KL+ L L N L L + +P+LE+LD+++N+L
Sbjct: 15 LNFFNNQI-EELPTQISSLQKLKHLNLGMNRLNTLPRG---FGSLPALEVLDLTYNNLSE 70
Query: 418 GRHKENCTWVESIVVLNLSSNMLTDSVFRCLPP------RIKVLDLHSNKIKSVPKQVVK 471
N ++ ++ L LS D+ F LPP ++++L L N + S+PK++ +
Sbjct: 71 NSLPGNFFYLTTLRALYLS-----DNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGE 125
Query: 472 LEALQELNVAFNSLTDLP----GCGSFSSLSVLIIDHNSVSHPSADFFQ 516
L L+EL++ N LT LP V ++N P AD FQ
Sbjct: 126 LTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQ 174
Score = 48.9 bits (115), Expect = 2e-05
Identities = 29/84 (34%), Positives = 50/84 (59%), Gaps = 4/84 (4%)
Query: 452 IKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLP-GCGSFSSLSVLIIDHNSVSHP 510
++VL+ +N+I+ +P Q+ L+ L+ LN+ N L LP G GS +L VL + +N++S
Sbjct: 12 LEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSEN 71
Query: 511 S--ADFFQSCQKMRSIKAGDNPFQ 532
S +FF +R++ DN F+
Sbjct: 72 SLPGNFFY-LTTLRALYLSDNDFE 94
Score = 32.7 bits (73), Expect = 1.4
Identities = 20/79 (25%), Positives = 45/79 (56%), Gaps = 1/79 (1%)
Query: 423 NCTWVESIVVLNLSSNMLTDSVFRCLP-PRIKVLDLHSNKIKSVPKQVVKLEALQELNVA 481
N ++++ VLN +N + + + ++K L+L N++ ++P+ L AL+ L++
Sbjct: 5 NIAELKNLEVLNFFNNQIEELPTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLT 64
Query: 482 FNSLTDLPGCGSFSSLSVL 500
+N+L++ G+F L+ L
Sbjct: 65 YNNLSENSLPGNFFYLTTL 83
>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
Length = 341
Score = 57.4 bits (137), Expect = 5e-08
Identities = 45/141 (31%), Positives = 68/141 (48%), Gaps = 14/141 (9%)
Query: 36 VDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSV 95
VD S + L VP DLP+ T+ L ++ N I + ++ EL VL L +N + L +
Sbjct: 92 VDCSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGL 151
Query: 96 FKFNQDLEYLDLSHNQLQKI------SCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLN 149
F + L +LDLS+N + H +V H+DLS N + + F L QL
Sbjct: 152 FLHAKRLAHLDLSYNNFSHVPADMFQEAHGLV---HIDLSHNPWLRRVHPQAFQGLMQLR 208
Query: 150 FL-----GLSAMKLQKLDLLP 165
L GL+ + L+ L+ LP
Sbjct: 209 DLDLSYGGLAFLSLEALEGLP 229
Score = 38.9 bits (89), Expect = 0.019
Identities = 46/141 (32%), Positives = 64/141 (45%), Gaps = 18/141 (12%)
Query: 432 VLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEA-LQELNVAFNSLTDLPG 490
V++ SS L SV LP + L L N+I +VP + LQ L++ NSL +LP
Sbjct: 91 VVDCSSQRLF-SVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPR 149
Query: 491 CGSF---SSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNP---------FQCTCELR 538
G F L+ L + +N+ SH AD FQ + I NP FQ +LR
Sbjct: 150 -GLFLHAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLR 208
Query: 539 EF---VKNIDQVSSEVLEGWP 556
+ + +S E LEG P
Sbjct: 209 DLDLSYGGLAFLSLEALEGLP 229
Score = 37.0 bits (84), Expect = 0.072
Identities = 46/198 (23%), Positives = 87/198 (43%), Gaps = 54/198 (27%)
Query: 433 LNLSSNMLTDSVFRCLPP-------RIKVLDLHSNKIKSVPKQV-VKLEALQELNVAFNS 484
L+L+ N +T +PP ++VLDLH+N + +P+ + + + L L++++N+
Sbjct: 113 LSLAHNRIT-----AVPPGYLTCYMELQVLDLHNNSLMELPRGLFLHAKRLAHLDLSYNN 167
Query: 485 LTDLPGCGSFSSLSVLIID--HNSVS---HPSADFFQSCQKMR----------------- 522
+ +P + ++ ID HN HP A FQ ++R
Sbjct: 168 FSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQA--FQGLMQLRDLDLSYGGLAFLSLEAL 225
Query: 523 -------SIKAGDNPFQCTCELREFVKNIDQVSSEVLEGWPDSY--KCDYPESYRGSPLK 573
+++ G NP+ C C + +K + + + DS +C P G+PL
Sbjct: 226 EGLPGLVTLQIGGNPWVCGCTMEPLLK---WLRNRIQRCTADSQLAECRGPPEVEGAPL- 281
Query: 574 DFHMSELS---CNITLLI 588
F ++E S C++TL +
Sbjct: 282 -FSLTEESFKACHLTLTL 298
>gi|153791466 AMIGO protein [Homo sapiens]
Length = 493
Score = 56.6 bits (135), Expect = 9e-08
Identities = 52/164 (31%), Positives = 80/164 (48%), Gaps = 7/164 (4%)
Query: 39 SKRGLIHVPKDLPLKTKVLDMSQNYIAELQVS-DMSFLSELTVLRLSHNRIQLLDLSVFK 97
SK+ L +VP LP T +LD+S N ++ L+ + L++L L LSHN + + F
Sbjct: 48 SKQQLPNVPHSLPSYTALLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFS 107
Query: 98 FNQDLEYLDLSHNQLQKISCHPIVSFRHLD---LSFNDFKALPICKEFGNLSQLNFLGLS 154
+L YLDLS NQL+ + + L+ L N A+ C F +++QL L LS
Sbjct: 108 PVPNLRYLDLSSNQLRTLDEFLFSDLQVLEVLLLYNNHIMAVDRC-AFDDMAQLQKLYLS 166
Query: 155 AMKLQK--LDLLPIAHLHLSYILLDLRNYYIKENETESLQILNA 196
++ + L+L+ LLDL + +K LQ L A
Sbjct: 167 QNQISRFPLELVKEGAKLPKLTLLDLSSNKLKNLPLPDLQKLPA 210
Score = 30.0 bits (66), Expect = 8.8
Identities = 34/166 (20%), Positives = 69/166 (41%), Gaps = 36/166 (21%)
Query: 407 ILDVSWNSLESGRHK---ENCTWVESIVVLNLSSNMLTDSVFRCLPPRIKVLDLHSNKIK 463
+LD+S N+L R + T + S+++ + N ++ F +P ++ LDL SN+++
Sbjct: 65 LLDLSHNNLSRLRAEWTPTRLTQLHSLLLSHNHLNFISSEAFSPVP-NLRYLDLSSNQLR 123
Query: 464 SVPKQVVK-LEALQELNVAFNSLTDLPGCG--SFSSLSVLIIDHNSVSHPSADFFQ---- 516
++ + + L+ L+ L + N + + C + L L + N +S + +
Sbjct: 124 TLDEFLFSDLQVLEVLLLYNNHIMAVDRCAFDDMAQLQKLYLSQNQISRFPLELVKEGAK 183
Query: 517 ---------SCQKMRSIKAGD----------------NPFQCTCEL 537
S K++++ D NP C CEL
Sbjct: 184 LPKLTLLDLSSNKLKNLPLPDLQKLPAWIKNGLYLHNNPLNCDCEL 229
>gi|150417978 platelet glycoprotein Ib alpha polypeptide precursor
[Homo sapiens]
Length = 639
Score = 55.8 bits (133), Expect = 1e-07
Identities = 49/157 (31%), Positives = 75/157 (47%), Gaps = 14/157 (8%)
Query: 36 VDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSV 95
V+ KR L +P DLP T +L +S+N + ++ + + LT L L +R +L L V
Sbjct: 31 VNCDKRNLTALPPDLPKDTTILHLSENLLYTFSLATLMPYTRLTQLNL--DRCELTKLQV 88
Query: 96 FKFNQDLEYLDLSHNQLQKISC--HPIVSFRHLDLSFNDFKALPI--CKEFGNLSQLNFL 151
L LDLSHNQLQ + + + LD+SFN +LP+ + G L +L
Sbjct: 89 DGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGALRGLGELQELYLK 148
Query: 152 GLSAMKL--------QKLDLLPIAHLHLSYILLDLRN 180
G L KL+ L +A+ +L+ + L N
Sbjct: 149 GNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLN 185
Score = 46.2 bits (108), Expect = 1e-04
Identities = 49/169 (28%), Positives = 77/169 (45%), Gaps = 30/169 (17%)
Query: 375 TLVKLETLILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLN 434
TL L TL L N L+ L L+ + +P+L +LDVS+N L S
Sbjct: 91 TLPVLGTLDLSHNQLQSL---PLLGQTLPALTVLDVSFNRLTS----------------- 130
Query: 435 LSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVV-KLEALQELNVAFNSLTDLPG--C 491
L R L ++ L L N++K++P ++ L++L++A N+LT+LP
Sbjct: 131 -----LPLGALRGL-GELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLL 184
Query: 492 GSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREF 540
+L L++ NS+ FF S + G NP+ C CE+ F
Sbjct: 185 NGLENLDTLLLQENSLYTIPKGFFGSHLLPFAFLHG-NPWLCNCEILYF 232
Score = 36.6 bits (83), Expect = 0.094
Identities = 41/161 (25%), Positives = 65/161 (40%), Gaps = 12/161 (7%)
Query: 433 LNLSSNMLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVKLEALQELNVAFNSLTDLP--G 490
LNL LT P + LDL N+++S+P L AL L+V+FN LT LP
Sbjct: 76 LNLDRCELTKLQVDGTLPVLGTLDLSHNQLQSLPLLGQTLPALTVLDVSFNRLTSLPLGA 135
Query: 491 CGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIK-AGDNPFQCTCELREFVKNIDQVSS 549
L L + N + K+ + A +N + L ++N+D +
Sbjct: 136 LRGLGELQELYLKGNELKTLPPGLLTPTPKLEKLSLANNNLTELPAGLLNGLENLDTLLL 195
Query: 550 EVLEGWPDSYKCDYPESYRGSPLKDF---HMSELSCNITLL 587
+ ++ P+ + GS L F H + CN +L
Sbjct: 196 Q------ENSLYTIPKGFFGSHLLPFAFLHGNPWLCNCEIL 230
>gi|41350214 asporin [Homo sapiens]
Length = 380
Score = 55.8 bits (133), Expect = 1e-07
Identities = 39/127 (30%), Positives = 63/127 (49%), Gaps = 1/127 (0%)
Query: 39 SKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSVFKF 98
S GL VP ++P T++LD+ N I E++ +D L+ L L L++N++ + F
Sbjct: 89 SDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLT 148
Query: 99 NQDLEYLDLSHNQLQKISCHPIVSFRHLDLSFNDFKALPICKEFGNLSQLNFLGLSAMKL 158
+ L L LSHNQL +I + S L + N K + F ++ L+ L +SA L
Sbjct: 149 TKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQ-KDTFKGMNALHVLEMSANPL 207
Query: 159 QKLDLLP 165
+ P
Sbjct: 208 DNNGIEP 214
Score = 33.1 bits (74), Expect = 1.0
Identities = 44/174 (25%), Positives = 76/174 (43%), Gaps = 31/174 (17%)
Query: 382 LILQKNGLKDLFKVGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLT 441
L LQ N +K++ + K + SL L ++ N L K T + + L LS N L+
Sbjct: 107 LDLQNNKIKEIKENDF--KGLTSLYGLILNNNKLTKIHPKAFLT-TKKLRRLYLSHNQLS 163
Query: 442 DSVFRCLPPRIKVLDLHSNKIKSVPKQVVK-LEALQELNVAFNSLTDLPGC--GSFSSLS 498
+ LP + L +H NK+K + K K + AL L ++ N L D G G+F ++
Sbjct: 164 EIPLN-LPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPL-DNNGIEPGAFEGVT 221
Query: 499 V-----------------------LIIDHNSVSHPSADFFQSCQKMRSIKAGDN 529
V L +D+N +S + F+ ++++ + G+N
Sbjct: 222 VFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNN 275
Score = 32.7 bits (73), Expect = 1.4
Identities = 24/85 (28%), Positives = 45/85 (52%), Gaps = 3/85 (3%)
Query: 403 PSLEILDVSWNSLESGRHKENCTWVESIVVLNLSSNMLTDSVFRCLP--PRIKVLDLHSN 460
P+L L + +N + S E+ + + L L +N +TD L PR++ + L +N
Sbjct: 241 PTLLELHLDYNKI-STVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENN 299
Query: 461 KIKSVPKQVVKLEALQELNVAFNSL 485
K+K +P + +L+ LQ + + NS+
Sbjct: 300 KLKKIPSGLPELKYLQIIFLHSNSI 324
Score = 30.0 bits (66), Expect = 8.8
Identities = 28/119 (23%), Positives = 48/119 (40%), Gaps = 26/119 (21%)
Query: 437 SNMLTDSVFRCLPPRIKVLDLHSNKIKSV-------------------------PKQVVK 471
S++ SV +P ++LDL +NKIK + PK +
Sbjct: 89 SDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLT 148
Query: 472 LEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNP 530
+ L+ L ++ N L+++P SL+ L I N V D F+ + ++ NP
Sbjct: 149 TKKLRRLYLSHNQLSEIP-LNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANP 206
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 55.8 bits (133), Expect = 1e-07
Identities = 81/322 (25%), Positives = 132/322 (40%), Gaps = 54/322 (16%)
Query: 35 AVDKSKRGLIHVPKDLPLKTKVL------------------------DMSQNYIAELQVS 70
AV ++R L VP +P +T++L D+S+N IA ++
Sbjct: 37 AVACTRRRLTAVPDGIPAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPG 96
Query: 71 DMSFLSELTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKI---SCHPIVSFRHLD 127
+ L L VLRL N+++L+ VF +L LDLS N+L + + + S R L+
Sbjct: 97 AFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLE 156
Query: 128 LSFNDFKALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYILLDLRNYYIKENE 187
+ ND + F L L L L L L + HL S L LR+ I E
Sbjct: 157 VGDNDL-VFVSRRAFAGLLALEELTLERCNLTALSGESLGHLR-SLGALRLRHLAIASLE 214
Query: 188 TESLQILNAKTLHLVFHPTSLFAIQVNISVNTLGCLQLTNIKLNDDNCQVFIKFLSELTR 247
++ + L LHL L ++ +L L LT++ + N
Sbjct: 215 DQNFRRLPG-LLHLEIDNWPLLE---EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQA 270
Query: 248 GSTLLNFTLNHIET----TWKCLVRVFQ---------------FLWPKPVEYLNIYNLTI 288
T LN + N I T +++ LVR+ + FL + + LN+ N +
Sbjct: 271 HLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSN-NL 329
Query: 289 IESIREEDFTYSKTTLKALTIE 310
+ ++ E F +S TL+ L ++
Sbjct: 330 LSTLEESTF-HSVNTLETLRVD 350
Score = 35.0 bits (79), Expect = 0.27
Identities = 49/222 (22%), Positives = 84/222 (37%), Gaps = 33/222 (14%)
Query: 375 TLVKLETLILQKNGLKDLFKVG-LMTKDMPSLEILDVSWNSLESGRHKENCTW------- 426
TL + L L L +G L + + + D ++ L H E W
Sbjct: 180 TLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVA 239
Query: 427 VESIVVLNLSSNMLTDSVFRCLPP-------RIKVLDLHSNKIKSVPKQVVK-LEALQEL 478
S+ LNL+S +T + +P + L+L N I +VP+ + L L+EL
Sbjct: 240 AGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLREL 299
Query: 479 NVA--FNSLTDLPGCGSFSSLSVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCE 536
++A ++ + + +L + +N +S F S + +++ NP C C
Sbjct: 300 HLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLACDCR 359
Query: 537 L-----REFVKNID----------QVSSEVLEGWPDSYKCDY 563
L R N D +V + L PDS +Y
Sbjct: 360 LLWIVQRRKTLNFDGRLPACATPAEVRGDALRNLPDSVLFEY 401
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 55.1 bits (131), Expect = 3e-07
Identities = 41/133 (30%), Positives = 70/133 (52%), Gaps = 10/133 (7%)
Query: 36 VDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNRIQLLDLSV 95
VD GL +PK++P T+ L+++ N I + +D + L +L VL+L N+I ++
Sbjct: 45 VDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGA 104
Query: 96 FKFNQDLEYLDLSHNQLQKISCHPIVSFRH------LDLSFNDFKALPICKEFGNLSQLN 149
F ++LE L L+ NQL + P + F++ LDLS N +A+P K F + L
Sbjct: 105 FDDMKELERLRLNRNQLHML---PELLFQNNQALSRLDLSENAIQAIP-RKAFRGATDLK 160
Query: 150 FLGLSAMKLQKLD 162
L L ++ ++
Sbjct: 161 NLQLDKNQISCIE 173
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/136 (25%), Positives = 56/136 (41%), Gaps = 12/136 (8%)
Query: 452 IKVLDLHSNKIKSVPKQ-VVKLEALQELNVAFNSLTDLPGCG--SFSSLSVLIIDHNSVS 508
++++DL +NKI S+ + L L +++N+L +P SL +L + N +S
Sbjct: 786 LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDIS 845
Query: 509 HPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSSEVLEGW--PDSYKCDYPES 566
F + + G NP C C LR +SS V G+ P +C P+
Sbjct: 846 TLQEGIFADVTSLSHLAIGANPLYCDCHLR-------WLSSWVKTGYKEPGIARCAGPQD 898
Query: 567 YRGSPLKDFHMSELSC 582
G L + C
Sbjct: 899 MEGKLLLTTPAKKFEC 914
Score = 40.0 bits (92), Expect = 0.009
Identities = 50/214 (23%), Positives = 97/214 (45%), Gaps = 23/214 (10%)
Query: 380 ETLILQKNGLKDLFK---VGLMTKDMPSLEILDVSWNSLESGRHKENCTWVESIVVLNLS 436
E L L N + + K GL K + L++++ ++E G + ++ + L L+
Sbjct: 64 ERLELNGNNITRIHKNDFAGL--KQLRVLQLMENQIGAVERGAFDD----MKELERLRLN 117
Query: 437 SN---MLTDSVFRCLPPRIKVLDLHSNKIKSVPKQVVK-LEALQELNVAFNSLTDLPGCG 492
N ML + +F+ + LDL N I+++P++ + L+ L + N ++ + G
Sbjct: 118 RNQLHMLPELLFQN-NQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEE-G 175
Query: 493 SFSSL---SVLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQVSS 549
+F +L VL +++N+++ F K+R+ + N C C L + + Q +
Sbjct: 176 AFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPT 235
Query: 550 EVLEGWPDSYKCDYPESYRGSPLKDFHMSELSCN 583
L +C P S RG + + SE SC+
Sbjct: 236 IGL-----FTQCSGPASLRGLNVAEVQKSEFSCS 264
Score = 39.7 bits (91), Expect = 0.011
Identities = 36/156 (23%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Query: 433 LNLSSNMLTDSVFRCLPPRIKVLDLH--SNKIKSVPKQVVK-LEALQELNVAFNSLTDLP 489
+NLS+N +++ V +LH +N+++S+ + + L+ L+ L + N ++ +
Sbjct: 570 INLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIH 629
Query: 490 GCGSFSSLS---VLIIDHNSVSHPSADFFQSCQKMRSIKAGDNPFQCTCELREFVKNIDQ 546
SF+ L +L + N ++ S F + Q + ++ NPF C C+L + +
Sbjct: 630 N-DSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRK 688
Query: 547 VSSEVLEGWPDSYKCDYPESYRGSPLKDFHMSELSC 582
+++ G P +C P+ R PL+D + C
Sbjct: 689 --RKIVTGNP---RCQNPDFLRQIPLQDVAFPDFRC 719
Score = 38.5 bits (88), Expect = 0.025
Identities = 33/107 (30%), Positives = 51/107 (47%), Gaps = 10/107 (9%)
Query: 28 FSDGNEFAVDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDMSFLSELTVLRLSHNR 87
+ DGN+F + G + K L L +D+S N I+ L S + +S+LT L LS+N
Sbjct: 767 YLDGNQFTLVP---GQLSTFKYLQL----VDLSNNKISSLSNSSFTNMSQLTTLILSYNA 819
Query: 88 IQLLDLSVFKFNQDLEYLDLSHNQ---LQKISCHPIVSFRHLDLSFN 131
+Q + F+ + L L L N LQ+ + S HL + N
Sbjct: 820 LQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGAN 866
Score = 37.0 bits (84), Expect = 0.072
Identities = 27/103 (26%), Positives = 48/103 (46%), Gaps = 7/103 (6%)
Query: 28 FSDGNEFAVDKSKRGLIHVPKDLPLKTKV----LDMSQNYIAELQVSDMSFLSELTVLRL 83
F D E + R +H+ +L + LD+S+N I + ++L L+L
Sbjct: 105 FDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQL 164
Query: 84 SHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHL 126
N+I ++ F+ + LE L L++N + I P+ SF H+
Sbjct: 165 DKNQISCIEEGAFRALRGLEVLTLNNNNITTI---PVSSFNHM 204
Score = 36.6 bits (83), Expect = 0.094
Identities = 30/115 (26%), Positives = 51/115 (44%), Gaps = 27/115 (23%)
Query: 451 RIKVLDLHSNKIKSV-PKQVVKLEALQELNVAFNSLTDLPG--CGSFSSLSVLIIDHNSV 507
+++ +DL +N+I + P L +L L + N +TDLP G +L +L+++ N +
Sbjct: 334 KLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKI 393
Query: 508 SHPSADFFQSCQ----------KMRSIKAG--------------DNPFQCTCELR 538
+ D FQ Q K++S+ G NPF C C L+
Sbjct: 394 NCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLK 448
Score = 36.2 bits (82), Expect = 0.12
Identities = 23/81 (28%), Positives = 43/81 (53%), Gaps = 1/81 (1%)
Query: 36 VDKSKRGLIHVPKDLPLKTKVLDMSQNYIAELQVSDM-SFLSELTVLRLSHNRIQLLDLS 94
V+ S L +P+ +P T L ++ N I+ L+ + M L+ L + LS+N++ ++
Sbjct: 524 VECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDG 583
Query: 95 VFKFNQDLEYLDLSHNQLQKI 115
F+ + L L+ NQL+ I
Sbjct: 584 AFEGAASVSELHLTANQLESI 604
Score = 32.7 bits (73), Expect = 1.4
Identities = 41/133 (30%), Positives = 61/133 (45%), Gaps = 8/133 (6%)
Query: 78 LTVLRLSHNRIQLLDLSVFKFNQDLEYLDLSHNQLQKISCHPIVSFRHLD---LSFNDFK 134
+T +RL N I+ + F + L +DLS+NQ+ +I+ R L+ L N
Sbjct: 311 MTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKIT 370
Query: 135 ALPICKEFGNLSQLNFLGLSAMKLQKLDLLPIAHLHLSYI-LLDLRNYYIKENETESLQI 193
LP FG L L L L+A K+ + P A L + LL L + I+ +
Sbjct: 371 DLP-RGVFGGLYTLQLLLLNANKIN--CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTS 427
Query: 194 LNA-KTLHLVFHP 205
L A +TLHL +P
Sbjct: 428 LRAIQTLHLAQNP 440
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.410
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,954,615
Number of Sequences: 37866
Number of extensions: 1195769
Number of successful extensions: 4882
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 190
Number of HSP's successfully gapped in prelim test: 81
Number of HSP's that attempted gapping in prelim test: 3418
Number of HSP's gapped (non-prelim): 1009
length of query: 796
length of database: 18,247,518
effective HSP length: 110
effective length of query: 686
effective length of database: 14,082,258
effective search space: 9660428988
effective search space used: 9660428988
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.