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Search of human proteins with 20070260
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20070260 cofactor of BRCA1 [Homo sapiens]
(580 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20070260 cofactor of BRCA1 [Homo sapiens] 1150 0.0
gi|48255900 SWI/SNF-related matrix-associated actin-dependent re... 33 0.72
gi|48255898 SWI/SNF-related matrix-associated actin-dependent re... 33 0.72
gi|7706067 ameloblastin precursor [Homo sapiens] 33 0.72
gi|110349719 titin isoform N2-A [Homo sapiens] 33 0.94
gi|110349717 titin isoform novex-2 [Homo sapiens] 33 0.94
gi|110349713 titin isoform novex-1 [Homo sapiens] 33 0.94
gi|110349715 titin isoform N2-B [Homo sapiens] 33 0.94
gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform ... 32 1.2
gi|219555718 synaptonemal complex central element protein 1 isof... 32 1.2
gi|219555716 synaptonemal complex central element protein 1 isof... 32 1.2
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 32 1.6
gi|15721939 metastatic lymph node 51 [Homo sapiens] 32 1.6
gi|31415870 dedicator of cytokinesis 3 [Homo sapiens] 31 2.7
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 31 3.6
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 31 3.6
gi|33188443 microfilament and actin filament cross-linker protei... 30 4.7
gi|33188445 microfilament and actin filament cross-linker protei... 30 4.7
gi|16507243 GSK-3 binding protein FRAT2 [Homo sapiens] 30 6.1
gi|239752250 PREDICTED: similar to acetylserotonin O-methyltrans... 30 8.0
gi|117553627 acetylserotonin O-methyltransferase-like [Homo sapi... 30 8.0
gi|150417989 cyclin K isoform 1 [Homo sapiens] 30 8.0
>gi|20070260 cofactor of BRCA1 [Homo sapiens]
Length = 580
Score = 1150 bits (2974), Expect = 0.0
Identities = 580/580 (100%), Positives = 580/580 (100%)
Query: 1 MFAGLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLE 60
MFAGLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLE
Sbjct: 1 MFAGLQDLGVANGEDLKETLTNCTEPLKAIEQFQTENGVLLPSLQSALPFLDLHGTPRLE 60
Query: 61 FHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHL 120
FHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHL
Sbjct: 61 FHQSVFDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHL 120
Query: 121 PKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTE 180
PKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTE
Sbjct: 121 PKVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTE 180
Query: 181 LSVLHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAE 240
LSVLHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAE
Sbjct: 181 LSVLHNFFSPSPKTRRQGEVVQRLTRMVGKNVKLYDMVLQFLRTLFLRTRNVHYCTLRAE 240
Query: 241 LLMSLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGD 300
LLMSLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGD
Sbjct: 241 LLMSLHDLDVGEICTVDPCHKFTWCLDACIRERFVDSKRARELQGFLDGVKKGQEQVLGD 300
Query: 301 LSMILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDMIDSQVF 360
LSMILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDMIDSQVF
Sbjct: 301 LSMILCDPFAINTLALSTVRHLQELVGQETLPRDSPDLLLLLRLLALGQGAWDMIDSQVF 360
Query: 361 KEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYPNTLPESFTKFLQEQRM 420
KEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYPNTLPESFTKFLQEQRM
Sbjct: 361 KEPKMEVELITRFLPMLMSFLVDDYTFNVDQKLPAEEKAPVSYPNTLPESFTKFLQEQRM 420
Query: 421 ACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLHLLTGNLALLADEFALED 480
ACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLHLLTGNLALLADEFALED
Sbjct: 421 ACEVGLYYVLHITKQRNKNALLRLLPGLVETFGDLAFGDIFLHLLTGNLALLADEFALED 480
Query: 481 FCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKEL 540
FCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKEL
Sbjct: 481 FCSSLFDGFFLTASPRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKEL 540
Query: 541 YSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAPL 580
YSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAPL
Sbjct: 541 YSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPAPL 580
>gi|48255900 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a2 isoform a [Homo sapiens]
Length = 1590
Score = 33.1 bits (74), Expect = 0.72
Identities = 14/24 (58%), Positives = 17/24 (70%)
Query: 556 PSPAQAAETPALELPLPSVPAPAP 579
P+P AA+ PA +P PSVP PAP
Sbjct: 289 PAPPAAAQPPAAAVPGPSVPQPAP 312
>gi|48255898 SWI/SNF-related matrix-associated actin-dependent
regulator of chromatin a2 isoform b [Homo sapiens]
Length = 1572
Score = 33.1 bits (74), Expect = 0.72
Identities = 14/24 (58%), Positives = 17/24 (70%)
Query: 556 PSPAQAAETPALELPLPSVPAPAP 579
P+P AA+ PA +P PSVP PAP
Sbjct: 289 PAPPAAAQPPAAAVPGPSVPQPAP 312
>gi|7706067 ameloblastin precursor [Homo sapiens]
Length = 447
Score = 33.1 bits (74), Expect = 0.72
Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 1/86 (1%)
Query: 495 PRKENVHRHALRLLIHLHPRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHR 554
PR+ ++ L +H P + L+ Q L+P QS A + L E L+ H
Sbjct: 91 PREHETQQYEYSLPVHPPPLPSQPSLKPQQPGLKPFLQSAAATTNQATALKEALQPPIHL 150
Query: 555 KPSPAQAAETPALELPL-PSVPAPAP 579
P Q E P ++ + PS P P
Sbjct: 151 GHLPLQEGELPLVQQQVAPSDKPPKP 176
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 32.7 bits (73), Expect = 0.94
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 495 PRKENVHRHALRLLIHLH-PRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDH 553
P++E V + LR P+V P KLE ++K P + V+E+ K E+
Sbjct: 10943 PKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRER--- 10999
Query: 554 RKPSPAQAAE-TPALELPLPSVPAPAP 579
+ P P + E PA+ LP P P P P
Sbjct: 11000 KIPEPTKVPEIKPAIPLPAPE-PKPKP 11025
>gi|110349717 titin isoform novex-2 [Homo sapiens]
Length = 27118
Score = 32.7 bits (73), Expect = 0.94
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 495 PRKENVHRHALRLLIHLH-PRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDH 553
P++E V + LR P+V P KLE ++K P + V+E+ K E+
Sbjct: 4638 PKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRER--- 4694
Query: 554 RKPSPAQAAE-TPALELPLPSVPAPAP 579
+ P P + E PA+ LP P P P P
Sbjct: 4695 KIPEPTKVPEIKPAIPLPAPE-PKPKP 4720
>gi|110349713 titin isoform novex-1 [Homo sapiens]
Length = 27051
Score = 32.7 bits (73), Expect = 0.94
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 495 PRKENVHRHALRLLIHLH-PRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDH 553
P++E V + LR P+V P KLE ++K P + V+E+ K E+
Sbjct: 4571 PKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRER--- 4627
Query: 554 RKPSPAQAAE-TPALELPLPSVPAPAP 579
+ P P + E PA+ LP P P P P
Sbjct: 4628 KIPEPTKVPEIKPAIPLPAPE-PKPKP 4653
>gi|110349715 titin isoform N2-B [Homo sapiens]
Length = 26926
Score = 32.7 bits (73), Expect = 0.94
Identities = 28/87 (32%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 495 PRKENVHRHALRLLIHLH-PRVAPSKLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDH 553
P++E V + LR P+V P KLE ++K P + V+E+ K E+
Sbjct: 4446 PKEEVVLKSVLRKRPEEEEPKVEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRER--- 4502
Query: 554 RKPSPAQAAE-TPALELPLPSVPAPAP 579
+ P P + E PA+ LP P P P P
Sbjct: 4503 KIPEPTKVPEIKPAIPLPAPE-PKPKP 4528
>gi|155030226 phosphatidylinositol 4-kinase type 3 alpha isoform 2
[Homo sapiens]
Length = 2044
Score = 32.3 bits (72), Expect = 1.2
Identities = 23/69 (33%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
Query: 63 QSVFDELRDKLLERVSAIASEGK-AEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLP 121
+ + DEL LLE + EGK A ER + L+ S S + L PV+ + + LP
Sbjct: 665 EHLVDELLMNLLELFVQLGLEGKRASERASEKGPALKASSSAGNLGVLIPVIAVLTRRLP 724
Query: 122 KVPEKKLKL 130
+ E K +L
Sbjct: 725 PIKEAKPRL 733
>gi|219555718 synaptonemal complex central element protein 1 isoform
4 [Homo sapiens]
Length = 351
Score = 32.3 bits (72), Expect = 1.2
Identities = 26/93 (27%), Positives = 50/93 (53%), Gaps = 7/93 (7%)
Query: 84 GKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAV 143
G + +K+EDL+E L K+ SL+P V ++ + +V + K K A+K+L A
Sbjct: 24 GGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKK---ANKDLGEART- 79
Query: 144 EVKRQIWQDNQALFGDEVSPLLKQYILEKESAL 176
+ + ++ +L G++V LK+ + +K+ L
Sbjct: 80 -ICEALQKELDSLHGEKVH--LKEILSKKQETL 109
>gi|219555716 synaptonemal complex central element protein 1 isoform
3 [Homo sapiens]
Length = 318
Score = 32.3 bits (72), Expect = 1.2
Identities = 26/93 (27%), Positives = 50/93 (53%), Gaps = 7/93 (7%)
Query: 84 GKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPEKKLKLVMADKELYRACAV 143
G + +K+EDL+E L K+ SL+P V ++ + +V + K K A+K+L A
Sbjct: 24 GGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKK---ANKDLGEART- 79
Query: 144 EVKRQIWQDNQALFGDEVSPLLKQYILEKESAL 176
+ + ++ +L G++V LK+ + +K+ L
Sbjct: 80 -ICEALQKELDSLHGEKVH--LKEILSKKQETL 109
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 32.0 bits (71), Expect = 1.6
Identities = 33/149 (22%), Positives = 67/149 (44%), Gaps = 15/149 (10%)
Query: 70 RDKLLERVSAIASEGKAEERYKKLEDLLEKS----FSLVKMPSLQPVVMCVMKHLP---- 121
++K +++ + + E K EE+ K +++ +K + P + V V K +
Sbjct: 634 KEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEK 693
Query: 122 KVPEKKLKLVMADKELYRACAVEVKRQIWQDNQALFGDEVSPLLKQYILEKESALFSTEL 181
K P+K++K KE+ + E K+++ + +E P + L K++ ST L
Sbjct: 694 KEPKKEVKKETPPKEVKKEVKKEEKKEVKK-------EEKEPKKEIKKLPKDAKKSSTPL 746
Query: 182 SVLHNFFSPSPKTRRQGEVVQRLTRMVGK 210
S + PK ++ E V++ + GK
Sbjct: 747 SEAKKPAALKPKVPKKEESVKKDSVAAGK 775
>gi|15721939 metastatic lymph node 51 [Homo sapiens]
Length = 703
Score = 32.0 bits (71), Expect = 1.6
Identities = 21/52 (40%), Positives = 24/52 (46%), Gaps = 3/52 (5%)
Query: 531 GQSGEAVKELYSQLGEKLEQLDHRKPSP---AQAAETPALELPLPSVPAPAP 579
G+SGE VK S +LEQ R PSP A +P E PA AP
Sbjct: 337 GRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAP 388
>gi|31415870 dedicator of cytokinesis 3 [Homo sapiens]
Length = 2030
Score = 31.2 bits (69), Expect = 2.7
Identities = 12/36 (33%), Positives = 25/36 (69%)
Query: 66 FDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSF 101
F ++ +L++++ ++ SEGK +E Y++L LL + F
Sbjct: 1132 FKQVEAELIDKLDSMVSEGKGDESYRELFSLLTQLF 1167
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform 5
[Homo sapiens]
Length = 6907
Score = 30.8 bits (68), Expect = 3.6
Identities = 18/63 (28%), Positives = 30/63 (47%)
Query: 66 FDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPE 125
F ++ L E + ++ E++ +KL D L K+ + V+ V KHLPK
Sbjct: 1851 FSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHV 1910
Query: 126 KKL 128
K+L
Sbjct: 1911 KEL 1913
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform 1
[Homo sapiens]
Length = 6885
Score = 30.8 bits (68), Expect = 3.6
Identities = 18/63 (28%), Positives = 30/63 (47%)
Query: 66 FDELRDKLLERVSAIASEGKAEERYKKLEDLLEKSFSLVKMPSLQPVVMCVMKHLPKVPE 125
F ++ L E + ++ E++ +KL D L K+ + V+ V KHLPK
Sbjct: 1851 FSNIKVNLKECFESSETKKSVEQKLQKLSDFLTLEGRNSKIKQVDSVLKHVKKHLPKAHV 1910
Query: 126 KKL 128
K+L
Sbjct: 1911 KEL 1913
>gi|33188443 microfilament and actin filament cross-linker protein
isoform b [Homo sapiens]
Length = 5938
Score = 30.4 bits (67), Expect = 4.7
Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 6/86 (6%)
Query: 18 ETLTNCTEPLKAIEQ---FQTENGVLLPSLQSALPFLDLHGTPRLEFHQSVFDELRDKLL 74
E L E +KA Q Q +N +L + QSA FLD HG Q + + +L
Sbjct: 2238 EKLDKQCEMMKARHQELLSQQQNFIL--ATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK 2295
Query: 75 ERVSAIASEGKAE-ERYKKLEDLLEK 99
E+ S ++ +AE ++ + L+D L+K
Sbjct: 2296 EQYSTSLAQSEAELKQVQTLQDELQK 2321
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 30.4 bits (67), Expect = 4.7
Identities = 27/86 (31%), Positives = 43/86 (50%), Gaps = 6/86 (6%)
Query: 18 ETLTNCTEPLKAIEQ---FQTENGVLLPSLQSALPFLDLHGTPRLEFHQSVFDELRDKLL 74
E L E +KA Q Q +N +L + QSA FLD HG Q + + +L
Sbjct: 1736 EKLDKQCEMMKARHQELLSQQQNFIL--ATQSAQAFLDQHGHNLTPEEQQMLQQKLGELK 1793
Query: 75 ERVSAIASEGKAE-ERYKKLEDLLEK 99
E+ S ++ +AE ++ + L+D L+K
Sbjct: 1794 EQYSTSLAQSEAELKQVQTLQDELQK 1819
>gi|16507243 GSK-3 binding protein FRAT2 [Homo sapiens]
Length = 233
Score = 30.0 bits (66), Expect = 6.1
Identities = 21/48 (43%), Positives = 25/48 (52%), Gaps = 2/48 (4%)
Query: 531 GQSGEAVKELYSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAPA 578
G SGE V L +Q+GE L QLD + SPA P + L P A A
Sbjct: 35 GSSGE-VDRLVAQIGETL-QLDAAQDSPASPCAPPGVPLRAPGPLAAA 80
>gi|239752250 PREDICTED: similar to acetylserotonin
O-methyltransferase-like [Homo sapiens]
Length = 320
Score = 29.6 bits (65), Expect = 8.0
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 8/76 (10%)
Query: 492 TASPRKENVHRHALRLLIHLHPRVAPSKL-EALQKA--LEPTGQSGEAVKELYSQLGEKL 548
+ASPR++ + +A L V PSK E L KA P G + E K+ ++ +L
Sbjct: 19 SASPRRQEILSNA-----GLRFEVVPSKFKEKLDKASFATPYGYAMETAKQKALEVANRL 73
Query: 549 EQLDHRKPSPAQAAET 564
Q D R P A+T
Sbjct: 74 YQKDLRAPDVVIGADT 89
>gi|117553627 acetylserotonin O-methyltransferase-like [Homo
sapiens]
Length = 621
Score = 29.6 bits (65), Expect = 8.0
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 8/76 (10%)
Query: 492 TASPRKENVHRHALRLLIHLHPRVAPSKL-EALQKA--LEPTGQSGEAVKELYSQLGEKL 548
+ASPR++ + +A L V PSK E L KA P G + E K+ ++ +L
Sbjct: 19 SASPRRQEILSNA-----GLRFEVVPSKFKEKLDKASFATPYGYAMETAKQKALEVANRL 73
Query: 549 EQLDHRKPSPAQAAET 564
Q D R P A+T
Sbjct: 74 YQKDLRAPDVVIGADT 89
>gi|150417989 cyclin K isoform 1 [Homo sapiens]
Length = 580
Score = 29.6 bits (65), Expect = 8.0
Identities = 17/59 (28%), Positives = 25/59 (42%), Gaps = 6/59 (10%)
Query: 519 KLEALQKALEPTGQSGEAVKELYSQLGEKLEQLDHRKPSPAQAAETPALELPLPSVPAP 577
K+E L P + L + LGE P P A + P +++P P+ PAP
Sbjct: 357 KIETTHPPLPPAHPPPDRKPPLAAALGEA------EPPGPVDATDLPKVQIPPPAHPAP 409
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.138 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,889,247
Number of Sequences: 37866
Number of extensions: 1026247
Number of successful extensions: 3881
Number of sequences better than 10.0: 22
Number of HSP's better than 10.0 without gapping: 7
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 3807
Number of HSP's gapped (non-prelim): 96
length of query: 580
length of database: 18,247,518
effective HSP length: 108
effective length of query: 472
effective length of database: 14,157,990
effective search space: 6682571280
effective search space used: 6682571280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.