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Search of human proteins with 20070228
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|20070228 nucleobindin 1 [Homo sapiens]
(461 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|20070228 nucleobindin 1 [Homo sapiens] 920 0.0
gi|4826870 nucleobindin 2 [Homo sapiens] 493 e-139
gi|148746195 trichohyalin [Homo sapiens] 67 4e-11
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 64 2e-10
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 64 2e-10
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 63 5e-10
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 61 2e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 61 2e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 60 5e-09
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 59 7e-09
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 58 2e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 57 4e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 57 5e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 57 5e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 57 5e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 57 5e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 57 5e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 57 5e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 57 5e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 57 5e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 56 8e-08
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 55 1e-07
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 55 1e-07
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 55 1e-07
gi|34878777 ring finger protein 20 [Homo sapiens] 54 2e-07
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 54 2e-07
gi|31982906 cingulin-like 1 [Homo sapiens] 54 2e-07
gi|21735548 centrosomal protein 2 [Homo sapiens] 53 5e-07
gi|221139761 zinc finger protein 853 [Homo sapiens] 53 7e-07
gi|38569484 kinesin family member 21A [Homo sapiens] 52 1e-06
>gi|20070228 nucleobindin 1 [Homo sapiens]
Length = 461
Score = 920 bits (2379), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVID 60
MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVID
Sbjct: 1 MPPSGPRGTLLLLPLLLLLLLRAVLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVID 60
Query: 61 VLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMD 120
VLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMD
Sbjct: 61 VLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMD 120
Query: 121 AEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYE 180
AEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYE
Sbjct: 121 AEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYE 180
Query: 181 MLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
MLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP
Sbjct: 181 MLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
Query: 241 NRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHV 300
NRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHV
Sbjct: 241 NRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHV 300
Query: 301 MKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAE 360
MKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAE
Sbjct: 301 MKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAE 360
Query: 361 LNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
LNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL
Sbjct: 361 LNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
Query: 421 KFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL 461
KFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL
Sbjct: 421 KFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPEVEVPQHL 461
>gi|4826870 nucleobindin 2 [Homo sapiens]
Length = 420
Score = 493 bits (1268), Expect = e-139
Identities = 255/415 (61%), Positives = 309/415 (74%), Gaps = 14/415 (3%)
Query: 15 LLLLLLLRAVLAVPLERGAPNKE-----ETPATESPDTGLYYHRYLQEVIDVLETDGHFR 69
LL+ LL A+ AVP++ + E+ E PDTGLYY YL++VIDVLETD HFR
Sbjct: 13 LLITCLLTALEAVPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFR 72
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
EKLQ A+ E+IKSG+LS+ELD VSHHVRTKLDELKRQEV RLRML+KAK+D+ QD + +
Sbjct: 73 EKLQKADIEEIKSGRLSKELDLVSHHVRTKLDELKRQEVGRLRMLIKAKLDSLQD--IGM 130
Query: 130 DHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRR 189
DH LLKQF+HL+ N FE+ DL++LI+ AT DL YD HEEFK+YEM+KEHERR
Sbjct: 131 DHQALLKQFDHLNHLNPDKFESTDLDMLIKAATSDLEHYDKTRHEEFKKYEMMKEHERRE 190
Query: 190 YLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFF 249
YL++L EE+RKE E K EE +++H HPKVN PGS+ QLKEVWEE DGLDPN F+PKTFF
Sbjct: 191 YLKTLNEEKRKEEESKFEEMKKKHENHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFF 250
Query: 250 ILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQD 309
LHD+NSDG LDEQELEALFTKELEKVYDPKNEEDDM EMEEERLRMREHVM VDTN+D
Sbjct: 251 KLHDVNSDGFLDEQELEALFTKELEKVYDPKNEEDDMVEMEEERLRMREHVMNEVDTNKD 310
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
RLVTLEEFL +T++KEF + + WET++ +TEEEL+ +E +A +E EL KA L
Sbjct: 311 RLVTLEEFLKATEKKEFLEP-DSWETLDQQQFFTEEELKEYENIIALQENELKKKADELQ 369
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHP 424
++ E L R +LEAQK E Q + MEQ+K QQ P + P G+LKF P
Sbjct: 370 KQKEELQRQHDQLEAQKLEYHQVIQQMEQKKLQQ------GIPPSGPAGELKFEP 418
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 66.6 bits (161), Expect = 4e-11
Identities = 78/373 (20%), Positives = 158/373 (42%), Gaps = 36/373 (9%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
++L+ E+ + +L RE + +L+R++ R L+ + ++ ++
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421
Query: 130 DHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRD---LAQYDAAHHEEFKRYEMLK--- 183
+ L ++ E + +H E R+ L + R + + HE+ +R + LK
Sbjct: 422 EQ-QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQ 480
Query: 184 EHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRF 243
E ERR L EE+R+E + + E+Q RR +E + Q + + + + L R
Sbjct: 481 EEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Query: 244 NPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKN 303
E+ E L +E EK + + E ++ +EER R+ ++K
Sbjct: 541 E----------------QEERREQLLKREEEKRLEQERREQRLKREQEER---RDQLLKR 581
Query: 304 VDTNQDRLV--TLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAEL 361
+ + + + EE L ++E + E E E E E R ++ L + E E
Sbjct: 582 EEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQE- 640
Query: 362 NAKAQRLSQETEALGRSQGRLEAQKRELQQAVL--HMEQRKQQ-----QQQQQGHKAPAA 414
+ Q+L +E + + + E ++ L+Q + H E+R++Q +Q+Q + +
Sbjct: 641 ERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSR 700
Query: 415 HPEGQLKFHPDTD 427
P+ Q + + D
Sbjct: 701 IPKWQWQLESEAD 713
Score = 57.8 bits (138), Expect = 2e-08
Identities = 76/311 (24%), Positives = 125/311 (40%), Gaps = 40/311 (12%)
Query: 144 QNQHTFEARDLELLIQTATRDLAQYD------AAHHEEFKRYEMLKEHERRRYLESLGEE 197
++Q FE RD +L + R + A E+ ++ E L++ +R+R E L +
Sbjct: 117 EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQ 176
Query: 198 ----QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEEL--DGLDPNRFNPKTFFIL 251
Q +E R EEQ + + H P + + EL G + + +
Sbjct: 177 RQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE---- 232
Query: 252 HDINSDGVLDEQE------LEALFTKELEKVYDPK--------NEEDDMREMEEERLRMR 297
D V E+E E + KE EK+ + + EE+ +R++E + LR
Sbjct: 233 ---RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRE 289
Query: 298 EHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEE---- 353
+ R L +R++ + E E E E++LRR +EE
Sbjct: 290 RQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQ 349
Query: 354 LAAREAELNAKAQRLSQETEALGRSQG-RLEAQKRELQQAVLHMEQRKQQQ--QQQQGHK 410
RE E + Q+L +E E R Q R E Q R QQ + R++QQ ++QQ +
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Query: 411 APAAHPEGQLK 421
E QL+
Sbjct: 410 EQQLRREQQLR 420
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/392 (21%), Positives = 165/392 (42%), Gaps = 49/392 (12%)
Query: 30 ERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSREL 89
ERG +++ + L R Q+ + E D FR + Q ++ + + E
Sbjct: 1544 ERGQQRRQDRDRKFREEEQLRQEREEQQ-LSRQERDRKFRLEEQKVRRQEQERKFMEDEQ 1602
Query: 90 DFVSHHVRTKLDELKRQEVSRLRMLLKAKMDA-----EQDPNVQVDHLNLLKQFEHLDPQ 144
+ +L + + ++ LL+ + + E+D + L +Q +
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR 1662
Query: 145 NQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHER-RRYLESLGEEQRKEAE 203
+ + R+ E L+Q + + + + L+ ER R++L+ + +R+E E
Sbjct: 1663 HDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELE 1722
Query: 204 RKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ 263
RK E+++ +E + + Q + +++ EE + L P R +EQ
Sbjct: 1723 RKFREEEQLRQETEQEQL-RRQERYRKILEE-EQLRPER------------------EEQ 1762
Query: 264 ELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQR 323
+L + E+ + EE +E EE++LR +E K + Q R E+ L QR
Sbjct: 1763 QL-----RRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQR 1817
Query: 324 KEFGDTGEGWETVEMHPAYTEEELR-------RFEEELAAREAELNAKAQRLSQETEALG 376
D WE ++ E+ LR R EE+ A +E + + Q L QE E
Sbjct: 1818 ----DGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE-KSRREEQELWQEEE--- 1869
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQQQG 408
Q R + ++R+L++ + +Q+++Q+ +Q G
Sbjct: 1870 --QKRRQERERKLREEHIRRQQKEEQRHRQVG 1899
Score = 55.8 bits (133), Expect = 8e-08
Identities = 64/275 (23%), Positives = 111/275 (40%), Gaps = 43/275 (15%)
Query: 144 QNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAE 203
Q + R+ EL L + + A + + + ++ ERRR +EQR++ +
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRR-----SQEQRRDQK 873
Query: 204 RKLE-EQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE 262
+ + E++R+ R H P Q QL++ + L + L
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQ------------------EEEEELQR 915
Query: 263 QELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQ 322
+E E +E E+ Y E++ + EEE+L +RE K ++R ++ L +
Sbjct: 916 EEREKRRRQEQERQY----REEEQLQQEEEQL-LREEREKRRRQERERQYRKDKKLQQKE 970
Query: 323 RKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQ----------RLSQET 372
+ G+ E E Y EEE + EEE RE + Q L QE
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 373 EALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
E L R E +KR LQ+ + ++ QQ+++
Sbjct: 1031 EQLLRE----EREKRRLQERERQYREEEELQQEEE 1061
Score = 55.1 bits (131), Expect = 1e-07
Identities = 57/243 (23%), Positives = 109/243 (44%), Gaps = 37/243 (15%)
Query: 174 EEFKRYEML---------KEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGS 224
E+ +R E+L K+ +RR + + +E+ ++ RK E R+ E + P
Sbjct: 208 EQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQR 267
Query: 225 QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEED 284
Q +L+E E+L L+ ++ + +EQ+ + L ++ + + +E+
Sbjct: 268 QRELQEEEEQLRKLERQ-----------ELRRERQEEEQQQQRLRREQQLR----RKQEE 312
Query: 285 DMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTE 344
+ RE +EER +E + + + +L R+E + E E E
Sbjct: 313 ERREQQEERREQQERREQQEERREQQL-----------RREQEERREQQLRREQEEERRE 361
Query: 345 EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQ 404
++LRR +EE RE +L + Q+L +E + Q R E Q R QQ + R++QQ
Sbjct: 362 QQLRREQEE-ERREQQLR-REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 419
Query: 405 QQQ 407
+++
Sbjct: 420 RRE 422
Score = 53.9 bits (128), Expect = 3e-07
Identities = 72/325 (22%), Positives = 135/325 (41%), Gaps = 39/325 (12%)
Query: 101 DELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLI-- 158
+EL+R+E + R + + E++ Q + L ++ E Q + +D +L
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKE 970
Query: 159 --------QTATRDLAQYDAAHHEEFKRYE--MLKEHERRRYLESLGEEQRKEAERKLEE 208
+ R + EE ++ E +L+E +R + + RK+ E + EE
Sbjct: 971 EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEE 1030
Query: 209 QQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEAL 268
+Q E K + + Q +E EEL + L +E E
Sbjct: 1031 EQLLREEREKRRLQERERQYREE-EELQ------------------QEEEQLLGEERETR 1071
Query: 269 FTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGD 328
+ELE+ Y +E+++++ EE+ LR E K ++R EE L + + +
Sbjct: 1072 RRQELERQY---RKEEELQQEEEQLLR--EEPEKRRRQERERQCREEEELQQEEEQLLRE 1126
Query: 329 TGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS---QETEALGRSQGRLEAQ 385
E E+ Y EEE + EEE RE + Q L +E E L + + +L +
Sbjct: 1127 EREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLRE 1186
Query: 386 KRELQQAVLHMEQRKQQQQQQQGHK 410
++E ++ + R++++ Q+Q K
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRK 1211
Score = 52.8 bits (125), Expect = 7e-07
Identities = 79/356 (22%), Positives = 145/356 (40%), Gaps = 44/356 (12%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ + + + +R + R K +EL+++E LR + + E++ +
Sbjct: 1054 EELQQEEEQLLGEERETRRRQELERQYR-KEEELQQEEEQLLREEPEKRRRQERERQCRE 1112
Query: 130 DHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRR 189
+ L ++ E L + + ++LE QY + + ++L+E +R
Sbjct: 1113 EE-ELQQEEEQLLREEREKRRRQELE----------RQYREEEEVQQEEEQLLREEPEKR 1161
Query: 190 YLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFF 249
+ L + R+E E + EE+Q E K + +E EEL R K +
Sbjct: 1162 RRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREE--EELQ-----RQKRKQRY 1214
Query: 250 ILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQD 309
D SD + + E E KVY E + R++E+ +LR R+ + QD
Sbjct: 1215 RDEDQRSD-LKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQ-------SQQD 1266
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
L+ L Q ++ W+ + H + EEE EE+ A+ + R S
Sbjct: 1267 ----LQHLLGEQQERDREQERRRWQQRDRH--FPEEEQLEREEQKEAKRRD------RKS 1314
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPD 425
QE + L R + + +++E + EQ Q++++Q P E KF +
Sbjct: 1315 QEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQ-----PLRRQERDRKFREE 1365
Score = 52.0 bits (123), Expect = 1e-06
Identities = 77/383 (20%), Positives = 166/383 (43%), Gaps = 46/383 (12%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLR 112
R +E ++ LE + ++L+ E+ + +L + + +L+R++ R
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKS----EEQEERRQQQLRREQQERRE 656
Query: 113 MLLKAKMDAEQ-DPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAA 171
LK + + E+ + ++ +H ++ E L + Q R + + + ++ DA
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERREQE-LAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 172 HHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEV 231
+ + R K+ +RR E + +R+E+E + +E++R HR+ + +
Sbjct: 716 QSKVYSRPR--KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE---QRRDFTWQ 770
Query: 232 WEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREM-- 289
W+ + + R L + E++L A ++ E+ + P+ EE + R
Sbjct: 771 WQAEEKSERGRQRLSARPPLREQR------ERQLRAEERQQREQRFLPEEEEKEQRRRQR 824
Query: 290 -----------EEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVE- 337
EEE+L+ RE + + +D L +E S +++ D W+ E
Sbjct: 825 REREKELQFLEEEEQLQRRERA-QQLQEEEDGLQEDQERRRSQEQRR--DQKWRWQLEEE 881
Query: 338 ----MHPAYT----EEELRRFEEELAAREAEL--NAKAQRLSQETEALGRSQGRLEAQKR 387
H Y +E+LR+ ++ L E EL + +R QE E R + +L+ ++
Sbjct: 882 RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEE 941
Query: 388 ELQQAVLHMEQRKQQQQQQQGHK 410
+L + E+R++Q++++Q K
Sbjct: 942 QLLRE--EREKRRRQERERQYRK 962
Score = 50.4 bits (119), Expect = 3e-06
Identities = 93/394 (23%), Positives = 158/394 (40%), Gaps = 60/394 (15%)
Query: 63 ETDGHFREKLQAANA-EDIKSGKLSRELDFVSHHVRTK------LDE---LKRQEVSRLR 112
ETD FRE+ Q E+ + R+ F +R + L+E L+RQE R R
Sbjct: 1333 ETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE--RER 1390
Query: 113 MLLKAKMDA---EQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLA--- 166
LK + E++ ++ D ++ E + + + R+ E ++ R+
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLE 1450
Query: 167 ---QYDAAHHEEFKRYEML----------KEHERRRYLESLGEEQRKEAERKLEEQQRRH 213
Q H +F+ E L ++ R++LE + +R+E +RK EQ+ R
Sbjct: 1451 EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRS 1510
Query: 214 RE------HPKVNVPGSQAQLKEVWEELD------GLDPNRFNPKTF---FILHDINSDG 258
+E + + Q Q K + EE G + + F L +
Sbjct: 1511 QEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQ 1570
Query: 259 VLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFL 318
L QE + F E +KV + +E + + ME+E+ R+ + + +DR +E L
Sbjct: 1571 QLSRQERDRKFRLEEQKV---RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 319 ASTQRKEFGDTGEGWETVEMHPAYTEEE--LRRFEEELAA---REAELNAKAQRLSQETE 373
+R+E + E + EEE LRR E E R+ + + Q L + E
Sbjct: 1628 LQ-EREE-----QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE 1681
Query: 374 ALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
R Q R + E QQ +RK Q++QQ
Sbjct: 1682 QQLRRQERDRKFREEEQQLRRQERERKFLQEEQQ 1715
Score = 48.9 bits (115), Expect = 1e-05
Identities = 84/395 (21%), Positives = 156/395 (39%), Gaps = 65/395 (16%)
Query: 63 ETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKR-QEVSR----------- 110
+ D HF E+ Q E ++ + R+ +R + +E +R QE R
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 111 -----LRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQN-QHTFEARDLELLIQTATRD 164
LR + + E++ Q L++ + L Q + F + +L Q +
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ 1407
Query: 165 LAQ-YDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKL--EEQQRRHREHPKVNV 221
L Q D EE ++ ++ R++ E + +R+E ERK EEQQ R H K
Sbjct: 1408 LRQDRDRKFREE--EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFR- 1464
Query: 222 PGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVY---- 277
+ QL + EE L QE + F +E +++
Sbjct: 1465 --EEEQLLQEREEQQ-----------------------LHRQERDRKFLEEEQQLRRQER 1499
Query: 278 DPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLA----STQRKEFGDTGEGW 333
D K E ++R E ER + E + Q + + E+ L QR++ D +
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR-KFR 1558
Query: 334 ETVEMHPAYTEEELRRFEEELAAREAELNAKAQ----RLSQETEALGRSQGRLEAQK--- 386
E ++ E++L R E + R E + Q + ++ + L R +G+ + ++
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERD 1618
Query: 387 RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
R+ ++ +++R++QQ +Q E QL+
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLR 1653
Score = 48.5 bits (114), Expect = 1e-05
Identities = 82/392 (20%), Positives = 156/392 (39%), Gaps = 38/392 (9%)
Query: 30 ERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSREL 89
ER + P E + R ++ + LE + + + +A ++ + G +
Sbjct: 802 ERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQE 861
Query: 90 DFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTF 149
S R D+ R ++ R + + A+ Q+ L Q E + Q +
Sbjct: 862 RRRSQEQRR--DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Query: 150 EARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQ 209
+ R E Q + Q + +R + ++ R+Y + +Q++E E +
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPE 979
Query: 210 QRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALF 269
+RR +E K + +E+ +E + L +E E
Sbjct: 980 KRRRQEREK-----KYREEEELQQE----------------------EEQLLREEREKRR 1012
Query: 270 TKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDT 329
+E E+ Y K+E + EEE+L +RE K ++R EE L + + G+
Sbjct: 1013 RQEWERQYRKKDE----LQQEEEQL-LREEREKRRLQERERQYREEEELQQEEEQLLGEE 1067
Query: 330 GEGWETVEMHPAY-TEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQK 386
E E+ Y EEEL++ EE+L E E + +R Q E E L + + +L ++
Sbjct: 1068 RETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREE 1127
Query: 387 RE-LQQAVLHMEQRKQQQQQQQGHKAPAAHPE 417
RE ++ L + R++++ QQ+ + PE
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPE 1159
Score = 47.8 bits (112), Expect = 2e-05
Identities = 72/334 (21%), Positives = 137/334 (41%), Gaps = 46/334 (13%)
Query: 97 RTKLDELKRQEVSRLRMLLKAKMDA----EQDPNVQVDHLNLLKQFEHL---DPQNQHTF 149
R +L EL+R+ + + + D E++ + L K+ E L +PQ Q
Sbjct: 212 RRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 150 EARDLEL--LIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRK---EAER 204
+ + +L L + R Q + + +R + L RR+ E E+Q + + ER
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL----RRKQEEERREQQEERREQQER 327
Query: 205 KLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQE 264
+ ++++RR ++ + + QL+ EE + + EQE
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEE------------------ERREQQLRREQE 369
Query: 265 LEALFTKELEKVYDPKNEEDDMREME---EERLRMREHVMKNVDTNQDRLVTLEEFLAST 321
E ++L + + E+ RE + E++LR + + + +++ + E+ L
Sbjct: 370 -EERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 428
Query: 322 QRKEFGDTGEGWETVEMHPAYTEEELR---RFEEELAAREAELNAKAQRLSQETEALGR- 377
Q +E + E E +EE R + EEE E E + + QE E R
Sbjct: 429 QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Query: 378 ----SQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
+ R E Q+R QQ E+R++Q+ ++Q
Sbjct: 489 LKLEEEERREQQERREQQLRREQEERREQRLKRQ 522
Score = 47.4 bits (111), Expect = 3e-05
Identities = 65/333 (19%), Positives = 146/333 (43%), Gaps = 23/333 (6%)
Query: 101 DELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQT 160
+EL+++E LR + + + + + L K+ + ++Q + E +
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Query: 161 ATRDLAQY-DAAHHEEFKRYE--MLKEHERRRYLESL-GEEQRKEAERKLEEQQRRHREH 216
A RD Y +E+F++ E L++ + ++ L+ L GE+Q ++ E++ Q+R R
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293
Query: 217 PKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKV 276
P+ + QL+ E+ + +R + + +L + + QE + F +E + +
Sbjct: 1294 PE------EEQLERE-EQKEAKRRDRKSQEEKQLLREEREEK-RRRQETDRKFREEEQLL 1345
Query: 277 YDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ EE +R E +R + RE +++ + + L + + ++F +
Sbjct: 1346 QE--REEQPLRRQERDR-KFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQ 1402
Query: 337 EMHPAYTEEELRRFEEE---LAAREA-----ELNAKAQRLSQETEALGRSQGRLEAQKRE 388
E ++ R+F EE L+ +E E + +R +E + L Q + + R+
Sbjct: 1403 EREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRK 1462
Query: 389 LQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
++ +++R++QQ +Q E QL+
Sbjct: 1463 FREEEQLLQEREEQQLHRQERDRKFLEEEQQLR 1495
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 64.3 bits (155), Expect = 2e-10
Identities = 77/391 (19%), Positives = 180/391 (46%), Gaps = 43/391 (10%)
Query: 36 KEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAE----DIKSGKLSRELDF 91
+E T ++ LY + E ++ E + +EKLQ +E + +L R+L+
Sbjct: 184 EELTKERDALSLELYRNTITDE--ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 241
Query: 92 VSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA 151
+ + + + + + + AK+ A+ + N + LN +Q E + Q + +
Sbjct: 242 AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ-QQEEKMWRQEE---KI 297
Query: 152 RDLELLIQTATRDLAQYDAAHHEEFKRYEML---KEHERRRYLESLGEEQRKEAE----- 203
++ E IQ + + + E+ +R E + KE + RR E + E++ K E
Sbjct: 298 QEREEKIQEQEEKIREQE----EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 204 ---RKLEEQQRRHREHPKVNVPGS-QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGV 259
K+ EQ+ + +E K+ Q Q ++W + + + + + +
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR--------EQEEM 405
Query: 260 LDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVM---KNVDTNQDRLVTLEE 316
+ EQE E + +E EK+++ +E++M+E EE+ R E + K + ++++ EE
Sbjct: 406 MQEQE-EKMGEQE-EKMWE---QEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 317 FLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALG 376
+ + K G+ E E EE++RR EE++ +E ++ + +++ ++ E +
Sbjct: 461 MMQEQEEKMGEQEGKMCEQ-EAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 519
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
+ ++ Q+ ++ + M++++++ ++Q+
Sbjct: 520 EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 550
Score = 62.4 bits (150), Expect = 8e-10
Identities = 68/349 (19%), Positives = 163/349 (46%), Gaps = 24/349 (6%)
Query: 66 GHFREKLQAANAEDIKSGK----LSRELDFVSHHV--RTKLDELKRQEVSRLRMLLKAKM 119
G + L A + K+ + L++E D +S + T DE +++ ++L+ L+
Sbjct: 163 GELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVE 222
Query: 120 DAEQDPNVQVDHLNL-LKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKR 178
+ + + V L L++ + L PQ Q EA L +Q+ + L Q +E + R
Sbjct: 223 SEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKL-QAQVEENELWNR 281
Query: 179 YEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGL 238
+E + R EE+ +E E K++EQ+ + RE + + Q + +WE+ + +
Sbjct: 282 LNQQQEEKMWRQ-----EEKIQEREEKIQEQEEKIREQEEK----MRRQEEMMWEKEEKM 332
Query: 239 DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMRE 298
R + + + + E E + +E ++ + K E + R+ +E ++ +E
Sbjct: 333 ---RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 389
Query: 299 HVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAARE 358
++ Q+ + +E + Q ++ G+ E E EE++RR EE++ +E
Sbjct: 390 EKIRE----QEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQE 445
Query: 359 AELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
++ + +++ ++ E + + ++ Q+ ++ + M++++++ ++Q+
Sbjct: 446 KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQE 494
Score = 52.0 bits (123), Expect = 1e-06
Identities = 62/328 (18%), Positives = 144/328 (43%), Gaps = 37/328 (11%)
Query: 85 LSRELDFVSHHVRTKLDE------LKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQF 138
L +EL VS ++ +++E L +Q+ + M + + E++ +Q + +Q
Sbjct: 258 LGKELQSVSAKLQAQVEENELWNRLNQQQEEK--MWRQEEKIQEREEKIQEQEEKIREQE 315
Query: 139 EHLDPQNQHTFEA----RDLELLIQTATRDLAQYDAAHHEEFK---RYEMLKEHERRRYL 191
E + Q + +E R E ++ + + + HE+ K + E +E E+ R
Sbjct: 316 EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQ 375
Query: 192 ESLGEEQRK--EAERKLEEQQRRHREHPKVNVPGSQA---QLKEVWEELDGLDPNRFNPK 246
E E++ K E K+ EQ+ + RE ++ + Q +++WE+ + + +
Sbjct: 376 EKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR 435
Query: 247 TFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDT 306
+ + EQE K++ + + E+++M + +EE++ +E M +
Sbjct: 436 --------RQEEKIREQE------KKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEA 481
Query: 307 N---QDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNA 363
Q+ + +E Q K+ + E E EE++ EE++ +E ++
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541
Query: 364 KAQRLSQETEALGRSQGRLEAQKRELQQ 391
+ +++ ++ E + + RL Q+ ++Q+
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 29.6 bits (65), Expect = 6.0
Identities = 30/158 (18%), Positives = 71/158 (44%), Gaps = 13/158 (8%)
Query: 63 ETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAE 122
E + +E+ + ++ K + +++ +R + + ++ QE + KM E
Sbjct: 422 EQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQ--EGKM-CE 478
Query: 123 QDPNVQVDHLNLLKQFEHLDPQNQHTFEA----RDLELLIQTATRDLAQYDAAHHEEFKR 178
Q+ +Q + +Q E + Q + E R+ E ++Q + + + E+ ++
Sbjct: 479 QEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 538
Query: 179 YEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREH 216
+ +E RR+ EE+ +E E +L +Q+ + +EH
Sbjct: 539 MQEQEEKMRRQ------EEKMREQEVRLRQQEEKMQEH 570
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 64.3 bits (155), Expect = 2e-10
Identities = 60/326 (18%), Positives = 158/326 (48%), Gaps = 27/326 (8%)
Query: 96 VRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLE 155
+R + ++++ QE +M + +M E++ ++ + ++ E + Q + +E +
Sbjct: 384 IREQEEKIREQEE---KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK- 439
Query: 156 LLIQTATRDLAQYDAAHHEEFKRYE--MLKEHERRRYLESL----------GEEQRKEAE 203
I+ + + + +E KR E ++E E+R+ E+ EE+ +E E
Sbjct: 440 --IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQE 497
Query: 204 RKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ 263
K+ Q+ + E K+ + + +E+W + + + + +H+ + + +Q
Sbjct: 498 EKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHE--QEEKIRKQ 555
Query: 264 ELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDT--NQDRLVTLEEFLAST 321
E E ++ +E EK++D +E+ +RE EE+ R E + + + Q+ + +E +
Sbjct: 556 E-EKMWRQE-EKMHD---QEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQE 610
Query: 322 QRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGR 381
Q ++ G+ E E EE++RR EE++ +E ++ + +++ ++ E + + +
Sbjct: 611 QEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 670
Query: 382 LEAQKRELQQAVLHMEQRKQQQQQQQ 407
+ Q+ ++ + M++++++ ++Q+
Sbjct: 671 MWEQEEKMCEQEEKMQEQEEKMRRQE 696
Score = 51.6 bits (122), Expect = 1e-06
Identities = 76/398 (19%), Positives = 171/398 (42%), Gaps = 33/398 (8%)
Query: 36 KEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAE----DIKSGKLSRELDF 91
+E T ++ LY + E ++ E + +EKLQ +E + +L R+L+
Sbjct: 257 EELTKERDALSLELYRNTITDE--ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 314
Query: 92 VSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA 151
+ + + + + + + AK+ A+ + N + LN +Q E + Q + E
Sbjct: 315 AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ-QQEEKMWRQEEKIQEW 373
Query: 152 RDLELLIQTATRDLAQYDAAHHEEFKRYEML---KEHERRRYLESLGEEQRK-------- 200
+ + R+ + E+ +R E + KE + RR E + E++ K
Sbjct: 374 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMM 433
Query: 201 -EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGV 259
E E K+ E + + E K+ + Q +E E + K + I
Sbjct: 434 WEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE--AKMWRQEEKIREQEE 491
Query: 260 LDEQELEALFTKELEKVYDPKN--EEDDMREMEE-----ERLRMREHVMKNVDT--NQDR 310
++ E ++ +E EK+++ + EE+ +E EE E++R +E + + + Q+
Sbjct: 492 KIREQEEKMWRQE-EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEE 550
Query: 311 LVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEE-LAAREAELNAKAQRLS 369
+ +E Q ++ D E E + +EE R +EE + +E ++ + +
Sbjct: 551 KIRKQEEKMWRQEEKMHDQEEKIREQE-EKVWRQEEKIREQEEKIREQEEKIREQEEMTQ 609
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
++ E +G + ++ Q+ ++Q+ M +++++ ++Q+
Sbjct: 610 EQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQE 647
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/319 (19%), Positives = 139/319 (43%), Gaps = 46/319 (14%)
Query: 87 RELDFVSHHV-RTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQN 145
REL+ H + + E KRQE ++R K + EQ+ + + +Q E + Q
Sbjct: 441 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ---EQEAKMWRQEEKIREQEEKIREQE 497
Query: 146 QHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERR-RYLESLGEEQ---RKE 201
+ + + ++ Q R+ + E +++ E ++E E R E + E++ RK+
Sbjct: 498 EKMWRQEE-KIHEQEKIRE-EEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQ 555
Query: 202 AERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLD 261
E+ ++++ H + K+ + Q ++VW + + +
Sbjct: 556 EEKMWRQEEKMHDQEEKI-----REQEEKVWRQEEKI----------------------- 587
Query: 262 EQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTN---QDRLVTLEEFL 318
+E E ++ EK+ E+++M + +EE++ +E M + Q+ + +E
Sbjct: 588 -REQEEKIREQEEKI----REQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEK 642
Query: 319 ASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRS 378
Q K+ + E E EE++ EE++ +E ++ + +++ ++ E +
Sbjct: 643 IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 702
Query: 379 QGRLEAQKRELQQAVLHME 397
+ RL Q+ ++Q+ H+E
Sbjct: 703 EVRLRQQEEKMQEHQEHLE 721
Score = 45.1 bits (105), Expect = 1e-04
Identities = 77/372 (20%), Positives = 156/372 (41%), Gaps = 55/372 (14%)
Query: 91 FVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPN-VQVDHLNLLKQFEHLDPQNQHTF 149
+ S H +L+ R +SRL K + EQ + V + E L +
Sbjct: 208 YYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKER---- 263
Query: 150 EARDLELLIQTAT-RDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKL-- 206
+A LEL T T +L + +A E+ + L E E+ ++ E +RK KL
Sbjct: 264 DALSLELYRNTITDEELKEKNAKLQEKLQ----LVESEKSEIQLNVKELKRKLERAKLLL 319
Query: 207 -EEQQRRHREHPKVNVPGSQAQLK------EVWEELDGLDPNRFNPKTFFILHDINSDGV 259
++Q + +H + A+L+ E+W L+ + + I
Sbjct: 320 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKI--------- 370
Query: 260 LDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLA 319
QE E ++ EK+ + +E+ +RE +EE++R +E +M ++++ EE +
Sbjct: 371 ---QEWEEKIQEQEEKI---REQEEKIRE-QEEKMRRQEEMMWE---KEEKMRRQEEMMW 420
Query: 320 STQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQ 379
+ K WE EE++R EE++ +E ++ ++ E +
Sbjct: 421 EKEEKMRRQEEMMWEK--------EEKIRELEEKMHEQE--------KIREQEEKRQEEE 464
Query: 380 GRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQK 439
E +KR+ Q+A + ++ K ++Q+++ + + K H + + + +Q+
Sbjct: 465 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIH-EQEKIREEEKRQEQE 523
Query: 440 EVDTSEKKLLER 451
E+ E+K+ E+
Sbjct: 524 EMWRQEEKIREQ 535
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 63.2 bits (152), Expect = 5e-10
Identities = 70/366 (19%), Positives = 158/366 (43%), Gaps = 26/366 (7%)
Query: 63 ETDGHFREKLQAANAEDI---KSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKM 119
E D REK + ++ + K+ E +T+ E K QE R+R K
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMR 460
Query: 120 DAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDL-----ELLIQTATRDLAQYDAAHHE 174
+ E+ Q + + KQ E++ Q + ++ + L +L Q ++ + E
Sbjct: 461 EEEETMREQEEKMQ--KQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEE 518
Query: 175 EFKRYEMLKEHERRRYLESLGEEQRK---EAERKLEEQQRRHREHPKVNVPGSQAQLKEV 231
+ + E + E++ + + EQ E E K+ +Q+++ + + +Q Q K+
Sbjct: 519 KIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKT 578
Query: 232 WEELDGL---DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
W++ + + + R K ++ + QE E ++ EK+++ +E+ M+E
Sbjct: 579 WDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWE---QEEKMQE 635
Query: 289 MEEERLRMREHVMKNVDT--NQDRLVTLEEFL-----ASTQRKEFGDTGEGWETVEMHPA 341
EE+ E + + + Q RL +E L Q K + WE +M
Sbjct: 636 QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK 695
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQ 401
E+E + +++E E + + +++ +E E + + +++ Q+ ++Q+ M ++++
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 402 QQQQQQ 407
+ +Q+
Sbjct: 756 KMWEQE 761
Score = 55.8 bits (133), Expect = 8e-08
Identities = 65/368 (17%), Positives = 163/368 (44%), Gaps = 39/368 (10%)
Query: 63 ETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAE 122
E + R++ Q ++ + K ++E + + K+ E +R +M + +M E
Sbjct: 548 EQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMRE 607
Query: 123 QDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEML 182
Q+ +Q +Q E + Q + +E E + + + Q + +E K +E
Sbjct: 608 QEEKMQ-------EQEEKMQEQEEKMWEQE--EKMQEQEEKMWEQEEKMWEQEEKMWEQQ 658
Query: 183 KEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNR 242
+ E++ E L E ++ + + K++EQ+ + E K+ +Q Q K+ W++
Sbjct: 659 RLPEQK---EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKK-TQEQEKKTWDQ-------- 706
Query: 243 FNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPK--NEEDDMREMEEERLRMREHV 300
+ + + E+E + +E+ + + K +E+ M+E EEE E +
Sbjct: 707 ---------EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKM 757
Query: 301 MKNVDT--NQDRLVTLEEFL----ASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEEL 354
+ + Q RL +E L ++++ + E E EE++R EE++
Sbjct: 758 WEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKM 817
Query: 355 AAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQR-KQQQQQQQGHKAPA 413
+E ++ + +++ + E + + ++ Q+ ++++ + E++ ++Q+++ +G +
Sbjct: 818 RGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKM 877
Query: 414 AHPEGQLK 421
E +++
Sbjct: 878 REQEEKMR 885
Score = 52.0 bits (123), Expect = 1e-06
Identities = 66/359 (18%), Positives = 161/359 (44%), Gaps = 54/359 (15%)
Query: 69 REKLQAAN--AEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPN 126
+ KL+ A +++ L E+ +R + ++++QE R + + EQ+
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR---EQEGK 308
Query: 127 VQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEE-FKRYEMLKEH 185
++ + +Q + L Q + E ++ EL Q R+ + E+ +++ E ++E
Sbjct: 309 MREQEEKMWRQEKRLREQEKELRE-QEKELREQKELREQEEQMQEQEEKMWEQEEKMREQ 367
Query: 186 ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGL----DPN 241
E + + + EE+ E E+++ EQ+++ R+ Q + +WE+ + L +
Sbjct: 368 EEKMWRQ---EERLWEQEKQMREQEQKMRD-----------QEERMWEQDERLREKEERM 413
Query: 242 RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVM 301
R K + + + + + EQE K + + + EEER+R RE M
Sbjct: 414 REQEKMWEQVEKMREEKKMQEQE--------------KKTRDQEEKMQEEERIREREKKM 459
Query: 302 KNVD----TNQDRLVTLEEFLASTQRKEF------GDTGEGWETVEM----HPAYTEEEL 347
+ + ++++ EE + + KE+ + WE +M + +EE
Sbjct: 460 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 519
Query: 348 RRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQ 406
R +EE+ +E ++ + +++ ++ + + + ++ Q++++ ME++ Q+Q+++
Sbjct: 520 IRDQEEMWGQEKKM-WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKK 577
Score = 50.4 bits (119), Expect = 3e-06
Identities = 53/244 (21%), Positives = 119/244 (48%), Gaps = 28/244 (11%)
Query: 135 LKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESL 194
+++ E + Q + +E +E +T ++ +D E+ + E ++E E++ E
Sbjct: 673 MQEQEKMQEQEEKIWEQEKMEK--KTQEQEKKTWD---QEKMREEESMREREKKMREE-- 725
Query: 195 GEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDI 254
EE +E E K++EQ+ + +E + Q +++WE+ + + + P+ L +
Sbjct: 726 -EEMMREQEEKMQEQEEKMQEQEEE----MWEQEEKMWEQEEKMWEQQRLPEQKEKLWEH 780
Query: 255 NSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTL 314
QE E ++ +E EK+ D +E+ MR +EE++R +E M+ ++++
Sbjct: 781 EK-----MQEQEKIWEQE-EKMRD---QEEKMRG-QEEKMRGQEEKMRG---QEEKMWGQ 827
Query: 315 EEFLASTQRKEFGDTGEGW---ETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQE 371
EE + + K +G + W E +E EE++R EE++ +E ++ + +++ +
Sbjct: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQ 887
Query: 372 TEAL 375
E +
Sbjct: 888 EEKI 891
Score = 48.9 bits (115), Expect = 1e-05
Identities = 63/298 (21%), Positives = 131/298 (43%), Gaps = 47/298 (15%)
Query: 170 AAHHEEFKRY--EMLKEHER---RRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGS 224
+ H++ RY E+ KE + Y ++ E+ K+ +L+E+ +P +
Sbjct: 189 STRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEK-----------LPLA 237
Query: 225 QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEED 284
+++ E+ +L+ + R + F+L + ++ + +E + +E EK K EE
Sbjct: 238 ESEKSEI--QLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIR-KQEEK 294
Query: 285 DMREMEEERLRMREHVMKNVDTN---QDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
R+ EERLR +E M+ + Q++ + +E Q KE +
Sbjct: 295 MWRQ--EERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE------------- 339
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRL---EAQKRELQQAVLHMEQ 398
++ELR EE++ +E ++ + +++ ++ E + R + RL E Q RE +Q + E+
Sbjct: 340 --QKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 399 RKQQQQQQQGHKAPAAHPEGQL-----KFHPDTDDVPVPAPAGDQKEVDTSEKKLLER 451
R +Q ++ K + ++ K + DQ+E E+++ ER
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIRER 455
Score = 48.9 bits (115), Expect = 1e-05
Identities = 55/310 (17%), Positives = 132/310 (42%), Gaps = 68/310 (21%)
Query: 112 RMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAA 171
+M + KM ++D + +Q E + Q Q + D E ++ T++ +
Sbjct: 532 KMWRQEKMREQED--------QMWEQEEKMRDQEQKMW---DQEERMEKKTQEQEKKTWD 580
Query: 172 HHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEV 231
E+ + E ++E E++ E EE +E E K++EQ+ + +E Q +++
Sbjct: 581 QEEKMREEERMREREKKMREE---EEMMREQEEKMQEQEEKMQE-----------QEEKM 626
Query: 232 WEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEE 291
WE+ + + QE E ++ EK+++ + + + + + E
Sbjct: 627 WEQEEKM------------------------QEQEEKMWEQEEKMWEQEEKMWEQQRLPE 662
Query: 292 ERLRMREHV----MKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYT---- 343
++ ++ EH + + ++++ E+ TQ +E + W+ +M +
Sbjct: 663 QKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE----KKTWDQEKMREEESMRER 718
Query: 344 -------EEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHM 396
EE +R EE++ +E ++ + + + ++ E + + ++ Q+R +Q
Sbjct: 719 EKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 778
Query: 397 EQRKQQQQQQ 406
E K Q+Q++
Sbjct: 779 EHEKMQEQEK 788
Score = 30.4 bits (67), Expect = 3.5
Identities = 41/206 (19%), Positives = 85/206 (41%), Gaps = 27/206 (13%)
Query: 101 DELKRQEVSRLR---MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELL 157
++++ +E R R M + +M EQ+ +Q + +Q E + Q + +E +
Sbjct: 707 EKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEE---- 762
Query: 158 IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHP 217
++ E K E L EHE+ + E + E++ K ++ EE+ R E
Sbjct: 763 --------KMWEQQRLPEQK--EKLWEHEKMQEQEKIWEQEEKMRDQ--EEKMRGQEEKM 810
Query: 218 KVNVPGSQAQLKEVW---EELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ + Q +++W E++ G + + + + + + QE K E
Sbjct: 811 RGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQE-----EKMRE 865
Query: 275 KVYDPKNEEDDMREMEEERLRMREHV 300
+ + +E+ MRE EE+ E +
Sbjct: 866 QEEKMRGQEEKMREQEEKMRGQEEKI 891
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 61.2 bits (147), Expect = 2e-09
Identities = 77/396 (19%), Positives = 179/396 (45%), Gaps = 60/396 (15%)
Query: 30 ERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSREL 89
ER AP+ E T + + + LQE + ++E++ + ++Q N +D+K +L
Sbjct: 198 ERDAPSLELYRNTITDEELKEKNAELQEKLRLVESE---KSEIQL-NVKDLKRKLERAQL 253
Query: 90 DFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLN------LLKQFEHLDP 143
++ + D L ++ S + AK+ A+ + N + LN + +Q E +
Sbjct: 254 LLPQQQLQVEADRLGKELQS-----VSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQE 308
Query: 144 QNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAE 203
Q + E EL I+ + + + HE+ E ++E E + + + EE+ +E E
Sbjct: 309 QEEKMCEQ---ELKIREQEEKMWRQEEKMHEQ---EEKIREQEDKMWRQ---EEKIREQE 359
Query: 204 RKLEEQQRRH-REHPKVNVPGS--QAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVL 260
K+ EQ+ + R+ K+ Q Q +E+W + + +
Sbjct: 360 EKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQ------------------- 400
Query: 261 DEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLAS 320
+E+ E ++ +E + + +++ +RE EEE R E + + + QD+ L E
Sbjct: 401 EEKRQEKMWRQEKKM----REQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK 456
Query: 321 TQRKEFGDTGEGWETVEMHP---------AYTEEELRRFEEELAAREAELNAKAQRLSQE 371
Q +E E E ++ + +E+L + EE++ +E ++ + +++ ++
Sbjct: 457 MQEEE-EKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQ 515
Query: 372 TEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
E + + +++ Q+ ++++ + + Q++++ Q+Q+
Sbjct: 516 EEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQE 551
Score = 58.2 bits (139), Expect = 2e-08
Identities = 69/338 (20%), Positives = 153/338 (45%), Gaps = 35/338 (10%)
Query: 84 KLSRELDFVSHHV--RTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNL-LKQFEH 140
KL++E D S + T DE +++ + L+ L+ + + + V L L++ +
Sbjct: 194 KLTKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQL 253
Query: 141 LDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRK 200
L PQ Q EA L +Q+ + L Q +E + +E + R E + E++ K
Sbjct: 254 LLPQQQLQVEADRLGKELQSVSAKL-QAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEK 312
Query: 201 EAERKL---EEQQRRHREHPKVNVPGSQAQLKE--VWEELDGLDPNRFNPKTFFILHDIN 255
E++L E++++ R+ K++ + + +E +W + + +
Sbjct: 313 MCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIR---------------E 357
Query: 256 SDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLE 315
+ + EQE E ++ +E EK+ + +++ ++E EEE R E + + + Q+++ E
Sbjct: 358 QEEKIREQE-EKMWRQE-EKI---REQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQE 412
Query: 316 EFLASTQRKEFGDTGEGWET------VEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ + K E W +E EE+LR EE++ E ++ + +++
Sbjct: 413 KKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ 472
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
++ E + + + Q++ L+Q EQ ++ +Q++
Sbjct: 473 RQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEE 510
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 60.8 bits (146), Expect = 2e-09
Identities = 58/319 (18%), Positives = 153/319 (47%), Gaps = 29/319 (9%)
Query: 96 VRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLE 155
+R + ++++RQE M+ + + + + + +++ E + + + + R+LE
Sbjct: 330 IREQEEKMRRQE----EMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE--KIRELE 383
Query: 156 LLIQTATRDLAQYDAAHHEE-FKRYEMLKEHERR--RYLESLGEEQRK--EAERKLEEQQ 210
+ + Q + EE + E +E E + R E + E++ K E E+K+ Q+
Sbjct: 384 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQE 443
Query: 211 RRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFT 270
+ E K+ + + +E+W + + + R + + ++ + +QE E ++
Sbjct: 444 EKIHEQEKIREEEKRQEQEEMWRQEEKI---REQEEIWRQKEKMHEQEKIRKQE-EKVWR 499
Query: 271 KELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDT--NQDRLVTLEEFLASTQRKEFGD 328
+E EK++D +E+ +RE EE+ R E + + + Q+ + +E + Q ++ G+
Sbjct: 500 QE-EKMHD---QEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGE 555
Query: 329 TGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRE 388
E + +E++RR EE++ +E ++ + +++ ++ E + + ++ Q+
Sbjct: 556 QEEKMQE--------QEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEM 607
Query: 389 LQQAVLHMEQRKQQQQQQQ 407
+Q+ M +++++ +Q+
Sbjct: 608 MQEQEEKMWEQEEKMCEQE 626
Score = 58.5 bits (140), Expect = 1e-08
Identities = 73/396 (18%), Positives = 172/396 (43%), Gaps = 30/396 (7%)
Query: 36 KEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAE----DIKSGKLSRELDF 91
+E T ++ LY + E ++ E + +EKLQ +E + +L R+L+
Sbjct: 196 EELTKERDALSLELYRNTITDE--ELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLER 253
Query: 92 VSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA 151
+ + + + + + + AK+ A+ + N + LN +Q E + Q + E
Sbjct: 254 AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQ-QQEEKMWRQEEKIQEW 312
Query: 152 RDLELLIQTATRDLAQYDAAHHEEFKRYEML---KEHERRRYLESLGEEQRK-------- 200
+ + R+ + E+ +R E + KE + RR E + E++ K
Sbjct: 313 EEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMM 372
Query: 201 -EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGV 259
E E K+ E + + E K+ Q + ++ E++ + + + + +
Sbjct: 373 WEKEEKIRELEEKMHEQEKIR---EQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE 429
Query: 260 LDEQELEALFTKELEKVYDPKN--EEDDMREMEE-----ERLRMREHVMKNVDT-NQDRL 311
+E E ++ EK+++ + EE+ +E EE E++R +E + + + ++
Sbjct: 430 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEK 489
Query: 312 VTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQE 371
+ +E Q ++ D E E EE++R EE++ +E ++ + + + ++
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549
Query: 372 TEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
E +G + +++ Q++ +Q EQ ++ ++Q++
Sbjct: 550 EEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKE 585
Score = 51.6 bits (122), Expect = 1e-06
Identities = 58/362 (16%), Positives = 160/362 (44%), Gaps = 37/362 (10%)
Query: 61 VLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMD 120
+ E + RE+ + ++ K + E+ + + +E+ ++ ++R L + +
Sbjct: 316 IQEQEEKIREQEEKIREQEEKMRR-QEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWE 374
Query: 121 AEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYE 180
E+ + ++ ++ + + Q + R+ E + + Q + +E E
Sbjct: 375 KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQE----E 430
Query: 181 MLKEHERR--RYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGL 238
++E E++ R E + E+++ E K +EQ+ R+ K+ + +E+W + + +
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIR------EQEEIWRQKEKM 484
Query: 239 -DPNRFNPKTFFI------LHDINSDGVLDEQEL----EALFTKELEKVYDPKN---EED 284
+ + + + +HD + + +++E E ++ EK+ + + E++
Sbjct: 485 HEQEKIRKQEEKVWRQEEKMHD-QEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQE 543
Query: 285 DMREMEEERLRMREHVMKNVDT---NQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
+M + +EE++ +E M+ + ++++ EE + + K + WE E
Sbjct: 544 EMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE 603
Query: 342 YTE------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLH 395
E E++ EE++ +E ++ + +++ ++ E + + RL Q+ ++Q+ H
Sbjct: 604 QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEH 663
Query: 396 ME 397
+E
Sbjct: 664 LE 665
Score = 45.4 bits (106), Expect = 1e-04
Identities = 57/305 (18%), Positives = 134/305 (43%), Gaps = 25/305 (8%)
Query: 87 RELDFVSHHV-RTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQN 145
REL+ H + + E KRQE ++R K + EQ+ + + +Q E + Q
Sbjct: 380 RELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ---EQEAKMWRQEEKIREQEEKIREQE 436
Query: 146 QHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERR-RYLESLGEEQ--RKEA 202
+ + + ++ Q R+ + E +++ E ++E E R E + E++ RK+
Sbjct: 437 KKMWRQEE-KIHEQEKIRE-EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQE 494
Query: 203 ERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE 262
E+ ++++ H + K+ + Q +++W + + + + + + ++
Sbjct: 495 EKVWRQEEKMHDQEEKI-----REQEEKMWRQEEKIREQEEKIRE-------QEEKIREQ 542
Query: 263 QELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKN---VDTNQDRLVTLEEFLA 319
+E+ +++ + + E++ MR EE+ E + + + ++++ EE +
Sbjct: 543 EEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIR 602
Query: 320 STQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQ 379
+ + WE E EE+++ EE++ +E ++ + RL Q+ E + Q
Sbjct: 603 EQEEMMQEQEEKMWEQEEKM-CEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQ 661
Query: 380 GRLEA 384
LEA
Sbjct: 662 EHLEA 666
Score = 43.5 bits (101), Expect = 4e-04
Identities = 68/334 (20%), Positives = 148/334 (44%), Gaps = 50/334 (14%)
Query: 150 EARDLELLIQTATRDLAQYD------AAHHEEFKRY--EMLKEHER---RRYLESLGEEQ 198
EARDL + + + + + A ++ RY E+ KE + Y ++ +E+
Sbjct: 159 EARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE 218
Query: 199 RKEAERKLEE-----------------QQRRHREHPKVNVPGSQAQLKEVWEELDGLDPN 241
KE KL+E + +R E K+ +P Q QL+ + L G +
Sbjct: 219 LKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLLLP--QQQLQAEADHL-GKELQ 275
Query: 242 RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYD----PKNEEDDMREMEEERLRMR 297
+ K + + L++Q+ E ++ +E EK+ + + +E+ +RE +EE++R +
Sbjct: 276 SVSAKLQAQVEENELWNRLNQQQEEKMWRQE-EKIQEWEEKIQEQEEKIRE-QEEKIREQ 333
Query: 298 EHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAR 357
E M+ Q+ ++ +E Q + + E +E EE++R EE++ +
Sbjct: 334 EEKMRR----QEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQ 389
Query: 358 EAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPE 417
E ++ ++ E + E +KR+ Q+A + ++ K ++Q+++ +
Sbjct: 390 E--------KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR 441
Query: 418 GQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLER 451
+ K H + + + +Q+E+ E+K+ E+
Sbjct: 442 QEEKIH-EQEKIREEEKRQEQEEMWRQEEKIREQ 474
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 59.7 bits (143), Expect = 5e-09
Identities = 45/240 (18%), Positives = 110/240 (45%), Gaps = 33/240 (13%)
Query: 183 KEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNR 242
+E + ++ E +GE++ E RK EEQ E + Q Q +++ ++ + +
Sbjct: 211 QEEQMQKQEEQMGEQE--EQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR--- 265
Query: 243 FNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMK 302
+ + EQE + L KE + + E+++ +EE++R +E M+
Sbjct: 266 ------------EQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR 313
Query: 303 NVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEM-------------HPAYTEEELRR 349
++++ EE + + + + + WE E EE++R+
Sbjct: 314 E---QEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRK 370
Query: 350 FEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGH 409
EE++ +E ++ + +++ ++ E +G + ++ QK ++++ M ++K+Q ++Q+ H
Sbjct: 371 QEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEH 430
Score = 49.3 bits (116), Expect = 7e-06
Identities = 62/346 (17%), Positives = 132/346 (38%), Gaps = 94/346 (27%)
Query: 61 VLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMD 120
V E +G RE+ ++ + G+ ++ ++ + +++ QE +M + +
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE---QMRKQEEQM 236
Query: 121 AEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYE 180
EQ+ VQ + KQ E + Q + E + EE +
Sbjct: 237 GEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEE---------------QMREQEE----Q 277
Query: 181 MLKEHERRRYLESLGE--EQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLKEVWEEL 235
MLK+ E+ E GE EQ +E E R+ EEQ R E + Q +++WE+
Sbjct: 278 MLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ- 336
Query: 236 DGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLR 295
EQ E +++ K + E+++ + +EE++R
Sbjct: 337 -------------------------KEQMWEQ--KEQMWKQEEQMGEQEEQMQKQEEQVR 369
Query: 296 MREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELA 355
+E M+ EE++R+ EE++
Sbjct: 370 KQEEQMRK---------------------------------------QEEQMRKQEEQMR 390
Query: 356 AREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQ 401
+E ++ + +++ ++ E + + ++ QK ++++ HM ++K+
Sbjct: 391 KQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 48.1 bits (113), Expect = 2e-05
Identities = 30/160 (18%), Positives = 79/160 (49%), Gaps = 4/160 (2%)
Query: 263 QELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVD-TNQDRLVTLEEFLAST 321
Q+ E K+ E++ + +E+ MRE EE+ E ++K + T Q+ +E
Sbjct: 244 QKQEEQVQKQEEQM---RKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMRE 300
Query: 322 QRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGR 381
Q ++ + E E EE++ + EE++ ++ ++ + +++ ++ E +G + +
Sbjct: 301 QEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQ 360
Query: 382 LEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
++ Q+ ++++ M ++++Q ++Q+ G+ K
Sbjct: 361 MQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQK 400
Score = 44.3 bits (103), Expect = 2e-04
Identities = 24/128 (18%), Positives = 70/128 (54%), Gaps = 5/128 (3%)
Query: 280 KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMH 339
+ +E +RE +E ++R +E ++ Q+ + +E Q ++ G+ E + E
Sbjct: 167 REQEGQVRE-QEGQVREQEGQVRE----QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQ 221
Query: 340 PAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQR 399
EE++R+ EE++ +E ++ + +++ ++ E + + + ++ Q+ ++++ M ++
Sbjct: 222 MGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQ 281
Query: 400 KQQQQQQQ 407
K+Q +Q++
Sbjct: 282 KEQTEQEE 289
Score = 41.2 bits (95), Expect = 0.002
Identities = 26/131 (19%), Positives = 66/131 (50%), Gaps = 4/131 (3%)
Query: 280 KNEEDDMREMEEERLRMREHVMKNVDTN---QDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ +E +RE +E ++R +E M + Q+ + +E Q ++ G+ E
Sbjct: 174 REQEGQVRE-QEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQ 232
Query: 337 EMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHM 396
E EE++++ EE++ +E ++ + +++ ++ E + + ++ QK + +Q
Sbjct: 233 EEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTG 292
Query: 397 EQRKQQQQQQQ 407
EQ +Q ++Q++
Sbjct: 293 EQEEQMREQEE 303
Score = 38.9 bits (89), Expect = 0.010
Identities = 32/161 (19%), Positives = 73/161 (45%), Gaps = 10/161 (6%)
Query: 280 KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMH 339
+ +E +RE E + V + +++ + E + +E G GE E
Sbjct: 146 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE-GQMGEQ----EGQ 200
Query: 340 PAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQR 399
EE++ EE++ +E ++ + +++ ++ E +G + +++ Q+ ++Q+ M R
Sbjct: 201 MGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQM--R 258
Query: 400 KQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPAPAGDQKE 440
KQ++Q ++ + E LK T+ G+Q+E
Sbjct: 259 KQEEQMREQEEQMREQEEQMLKQKEQTEQ---EEQTGEQEE 296
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 59.3 bits (142), Expect = 7e-09
Identities = 69/338 (20%), Positives = 154/338 (45%), Gaps = 35/338 (10%)
Query: 84 KLSRELDFVSHHV--RTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNL-LKQFEH 140
KL++E D +S + T DE +++ + L+ L+ + + + V L L++ +
Sbjct: 194 KLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQL 253
Query: 141 LDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRK 200
L PQ Q EA L +Q+ + L Q +E + +E + R E + E++ K
Sbjct: 254 LLPQQQLQVEADRLGKELQSVSAKL-QAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEK 312
Query: 201 EAERKL---EEQQRRHREHPKVNVPGSQAQLKE--VWEELDGLDPNRFNPKTFFILHDIN 255
E++L E++++ R+ K++ + + +E +W + + +
Sbjct: 313 MCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIR---------------E 357
Query: 256 SDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLE 315
+ + EQE E ++ +E EK+ + +++ ++E EEE R E + + + Q+++ E
Sbjct: 358 QEEKIREQE-EKMWRQE-EKI---REQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQE 412
Query: 316 EFLASTQRKEFGDTGEGWET------VEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ + K E W +E EE+LR EE++ E ++ + +++
Sbjct: 413 KKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQ 472
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
++ E + + + Q++ L+Q EQ ++ +Q++
Sbjct: 473 RQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEE 510
Score = 58.9 bits (141), Expect = 9e-09
Identities = 71/371 (19%), Positives = 169/371 (45%), Gaps = 60/371 (16%)
Query: 55 LQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRML 114
LQE + ++E++ + ++Q N +D+K +L ++ + D L ++ S
Sbjct: 223 LQEKLRLVESE---KSEIQL-NVKDLKRKLERAQLLLPQQQLQVEADRLGKELQS----- 273
Query: 115 LKAKMDAEQDPNVQVDHLN------LLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQY 168
+ AK+ A+ + N + LN + +Q E + Q + E EL I+ + +
Sbjct: 274 VSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQ---ELKIREQEEKMWRQ 330
Query: 169 DAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRH-REHPKVNVPGS--Q 225
+ HE+ E ++E E + + + EE+ +E E K+ EQ+ + R+ K+ Q
Sbjct: 331 EEKMHEQ---EEKIREQEDKMWRQ---EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQ 384
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDD 285
Q +E+W + + + +E+ E ++ +E + + +++
Sbjct: 385 EQEEEMWRQEEKIREQ-------------------EEKRQEKMWRQEKKM----REQDEK 421
Query: 286 MREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHP----- 340
+RE EEE R E + + + QD+ L E Q +E E E ++
Sbjct: 422 IREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEE-EKMQEQEEKIQRQEEKIQE 480
Query: 341 ----AYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHM 396
+ +E+L + EE++ +E ++ + +++ ++ E + + +++ Q+ ++++ + +
Sbjct: 481 QEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRL 540
Query: 397 EQRKQQQQQQQ 407
Q++++ Q+Q+
Sbjct: 541 WQQEEKMQEQE 551
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/325 (21%), Positives = 143/325 (44%), Gaps = 50/325 (15%)
Query: 84 KLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLN-LLKQFEHLD 142
KLS+E + + LD+L+ +E ++ +L KAK EQ QVD L L+Q + L
Sbjct: 994 KLSKEKKALQETHQQTLDDLQAEE-DKVNILTKAKTKLEQ----QVDDLEGSLEQEKKLR 1048
Query: 143 PQNQHTFEARDLEL-LIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKE 201
+ + +L L Q +T D+ E+ ++ KE E + + +EQ E
Sbjct: 1049 MDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEK----KEFEISNLISKIEDEQAVE 1104
Query: 202 AERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLD 261
+ Q++ +E QA+++E+ EE++ +R
Sbjct: 1105 IQL-----QKKIKE--------LQARIEELGEEIEAERASRAKA---------------- 1135
Query: 262 EQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLAST 321
++ + ++ELE++ + E + E + RE + + + + E + +
Sbjct: 1136 -EKQRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAA 1194
Query: 322 QRKEFGDT-GEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQG 380
RK+ D+ E E ++ L+R +++L ++EL + LS EA+ +++G
Sbjct: 1195 LRKKHADSMAELGEQID--------NLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKG 1246
Query: 381 RLEAQKRELQQAVLHMEQRKQQQQQ 405
LE R L+ V ++ ++++QQ+
Sbjct: 1247 NLEKMCRSLEDQVSELKTKEEEQQR 1271
Score = 37.0 bits (84), Expect = 0.038
Identities = 54/252 (21%), Positives = 117/252 (46%), Gaps = 27/252 (10%)
Query: 176 FKRYEMLKEHERRRYLESLGEEQRK--------EAERK-LEEQQ---RRHREHPKVNVPG 223
FK +LK E + + ++ EE +K EA+RK LEE+ + + ++ V
Sbjct: 837 FKIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQS 896
Query: 224 SQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDP---- 279
L + E + L N+ + + ++ ++ +E+E+ A T + K+ D
Sbjct: 897 EADSLADAEERCEQLIKNKIQLEAK--IKEV-TERAEEEEEINAELTAKKRKLEDECSEL 953
Query: 280 KNEEDDMREMEEERLRMREHVMKNVDTN-QDRLVTLEEFLA--STQRKEFGDTGEGWETV 336
K + DD+ E+ ++ +H +N N + + L+E +A S ++K +T + +T+
Sbjct: 954 KKDIDDL-ELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQ--QTL 1010
Query: 337 EMHPAYTEEE--LRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVL 394
+ A ++ L + + +L + +L ++ + L R++ +LE + Q++ +
Sbjct: 1011 DDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTM 1070
Query: 395 HMEQRKQQQQQQ 406
ME KQQ ++
Sbjct: 1071 DMENDKQQLDEK 1082
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 57.0 bits (136), Expect = 4e-08
Identities = 66/350 (18%), Positives = 167/350 (47%), Gaps = 26/350 (7%)
Query: 69 REKLQAAN--AEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPN 126
+ KL+ A +++ L E+ +R + ++++QE R + + EQ+
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLR---EQEGK 270
Query: 127 VQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEE-FKRYEMLKEH 185
++ + +Q + L Q + E ++ EL Q R+ + E+ +++ E ++E
Sbjct: 271 MREQEEKMRRQEKRLREQEKELRE-QEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 186 ERR--RYLESLGEEQR--KEAERKLEEQQRRHREHPKVNVPGSQAQLKE---VWEELDGL 238
E + R E L E+++ +E E+K+ +Q+ R E + + + +++E +WE+ + +
Sbjct: 330 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE-RLREKEERMREQEKMWEQEEKM 388
Query: 239 -DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMR 297
+ R + + + + +E E K+ E +++ + +E + + E++ ++
Sbjct: 389 QEEERIREREKKMREEEET-----MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW 443
Query: 298 EHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAR 357
E + + ++++ EE + Q + +G + W +M E+++ EE++ +
Sbjct: 444 EQ--EKMQEQEEKIWEQEEKIRD-QEEMWGQEKKMWRQEKMREQ--EDQMWEQEEKMRDQ 498
Query: 358 EAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
E ++ + +R+ ++ E L + R+ QK+ QQ E++K Q+Q+++
Sbjct: 499 EQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKK 548
Score = 53.5 bits (127), Expect = 4e-07
Identities = 52/267 (19%), Positives = 121/267 (45%), Gaps = 45/267 (16%)
Query: 196 EEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGL---DPNRFNPKTFFILH 252
+E+R ++K+ +Q+ + RE K +Q Q K+ W++ + + + R K
Sbjct: 519 KEERMREQKKMWQQEEKMREEKK-----TQEQEKKTWDQEEKMREEERMREREKKMREEE 573
Query: 253 DINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLV 312
++ + QE E ++ EK+++ +E+ M+E EE+ E + + + +D++
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWE---QEEKMQEQEEKMWEQEEKMWEQEE--EDKMQ 628
Query: 313 TLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQET 372
EE + + K + WE EE++R EE++ +E ++ + +++ ++
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQ--------EEKMREQEEKMREQEEKMQGQEEKMREQE 680
Query: 373 EALGRSQGRLEAQKREL---QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDV 429
E + + ++ Q+ ++ ++ + E++ Q+++ + E +++
Sbjct: 681 EKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIR-------- 732
Query: 430 PVPAPAGDQKEVDTSEKKLLERLPEVE 456
DQKE K+ ERLPE E
Sbjct: 733 -------DQKE------KMQERLPEHE 746
Score = 50.4 bits (119), Expect = 3e-06
Identities = 46/243 (18%), Positives = 107/243 (44%), Gaps = 44/243 (18%)
Query: 174 EEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE 233
E+ + E ++E E++ E EE +E E K++EQ+ + RE Q +++WE
Sbjct: 554 EKMREEERMREREKKMREE---EEMMREQEEKMQEQEEKMRE-----------QEEKMWE 599
Query: 234 ELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEER 293
+ + + QE E ++ EK+++ + EED M+E EE
Sbjct: 600 QEEKM------------------------QEQEEKMWEQEEKMWE-QEEEDKMQEQEEMM 634
Query: 294 LRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEE 353
E + + Q+ + +E Q ++ + E + E EE+++ EE+
Sbjct: 635 WEQEEKMQE-----QEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEK 689
Query: 354 LAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPA 413
+ +E ++ + +++ + E + + ++ Q+ ++ +Q+++ Q++ H+
Sbjct: 690 MREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERC 749
Query: 414 AHP 416
+ P
Sbjct: 750 SEP 752
Score = 42.7 bits (99), Expect = 7e-04
Identities = 32/136 (23%), Positives = 62/136 (45%), Gaps = 9/136 (6%)
Query: 281 NEEDDMREME-EERLRMREHVMKNVDTNQDRL--------VTLEEFLASTQRKEFGDTGE 331
NEE + E +E+LR+ E + N L L + +T ++E E
Sbjct: 182 NEELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 241
Query: 332 GWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQ 391
E EE++ R EE L +E ++ + +++ ++ + L + L Q++EL++
Sbjct: 242 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELRE 301
Query: 392 AVLHMEQRKQQQQQQQ 407
EQ +Q Q+Q++
Sbjct: 302 QKKLREQEEQMQEQEE 317
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 71 KLQAANAEDIKSGKLSRELDFVSHHVRTKL-DELKRQEVSRLRMLLKAKMDAEQDPNVQ- 128
+LQA A ++ R+ + +R ++ DE +R+ + + + + K +AE Q
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 129 ----VDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDL---------------AQYD 169
++ L L + + AR +++ ++TA R AQ +
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 170 AAHHEEFKRYEMLKEH-ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQL 228
+ EE L+E ERR ++ E R+EAER+LE Q + E ++ + Q
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-----QA 1648
Query: 229 KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+EV ++ L ++ +E E EA + E+ + RE
Sbjct: 1649 EEVAQQKS--------------LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRE 1688
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR 348
+ E+ L + + + T Q RL +E + E G E EEEL
Sbjct: 1689 LAEQELEKQRQLAEG--TAQQRLAAEQELIRLRAETEQG---------EQQRQLLEEELA 1737
Query: 349 RFEEELAA---REAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
R + E AA + EL A+ ++ E E L S+ R E + R E+ KQ+ +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEA 1791
Query: 406 QQGHKAPAAHPEGQLK 421
+ G A +L+
Sbjct: 1792 EAGRFRELAEEAARLR 1807
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/417 (19%), Positives = 171/417 (41%), Gaps = 79/417 (18%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ AE ++ + +++ VR +++EL + LKA+++AE +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK---------LKARIEAENRALILR 2257
Query: 130 DHLNLLKQF-EHLDPQNQHTFEARDLELLIQTATR-------DLAQYDAAHHEEFK-RYE 180
D N + E + Q EA L + Q A R DLAQ A + K + +
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 181 MLKEHERRRYLESLGEEQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLK-------E 230
++E R + L ++Q++ A+ R+L+E + + + G Q L+ E
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377
Query: 231 VWEELDGL----------------DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ E + L D RF + I ++ + ++++ + T E++
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437
Query: 275 KV---YDPKNEEDDMREMEEERLRMREHV-MKNVDTNQDRLVTLEEFLASTQRKEFGDTG 330
+ +D + + + E+E E+ ++++ + + + + + V E+ L TQ +
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 331 EGWETVEMHPAYTEEELRRFE--------------EELAAREAELNAKAQRLSQETEALG 376
E +++ + E+E + E EE ++ ++ + QRL E
Sbjct: 2498 EK-DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQ----------------QQGHKAPAAHPE 417
R Q E R Q+ + +EQ+++QQ++ ++ H+A AH E
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2613
Score = 42.7 bits (99), Expect = 7e-04
Identities = 88/383 (22%), Positives = 149/383 (38%), Gaps = 63/383 (16%)
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EVSRLRMLLKAKMDAEQDPNVQVDHL 132
AE +L+ E + + T+ E +RQ E++RL+ A Q+ ++ +
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 133 N-----LLKQFEHLDPQNQHTFEARDLELLIQTAT-RDLAQYDA---AHHEEFKRYEMLK 183
LL + +++ T E L + R+LA+ A A EE KR L
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 184 EHERRRY-----------LESLGEEQR-----------KEAE----RKLEEQQRRHREHP 217
E + R L ++GE R KEAE R+L E + R
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880
Query: 218 KVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ--ELEALFTK---- 271
+ +A ++E +L + + + + ++E+ L+A F K
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940
Query: 272 ----ELEKVYDPKNEEDDMREMEEERL---RMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
ELE N ED +R E+ L R R+ + ++ +++ LA+ + +
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA-EEE 1999
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
E VE A EE R L R + +A+ +L+QE +Q RL+A
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARR-----LRERAEQESARQLQLAQEA-----AQKRLQA 2049
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
+++ AV EQ QQ QQ+
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQE 2072
Score = 38.9 bits (89), Expect = 0.010
Identities = 64/257 (24%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 187 RRRYLESLGEEQRKEAERK------LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
R+R LE LG + R E L++ +RR + + + SQA +++ +E L+
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 241 -NRFNPKTF----FILHDINSDGVLDEQELEALFTK-ELEKVYDPKN------------- 281
R K F IN+ + + EL+ + K +LE V P
Sbjct: 1258 IERHGEKVEECQRFAKQYINA---IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
E D+R E + +K + R+ EE LA QR E E E+ A
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRMEE-EERLAEQQRAE-----ERERLAEVEAA 1368
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQ--KRELQQAVLHME 397
E+ R+ E A +A+ +A+ L Q + E + R + ++AQ KR +Q+ + +
Sbjct: 1369 L--EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 398 QRKQQQQQQQGHKAPAA 414
Q + + Q + +A AA
Sbjct: 1427 QSSEAEIQAKARQAEAA 1443
Score = 37.7 bits (86), Expect = 0.022
Identities = 87/413 (21%), Positives = 155/413 (37%), Gaps = 73/413 (17%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ---EVS 109
R+LQE + ++ +L A E + +L+ E + K+ + K Q E +
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 110 RLR-----MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA---RDLELL---- 157
RL+ + + ++ EQ +Q D + +Q Q T EA R LE+
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 158 -IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRY----------------LESLGEEQRK 200
++ ++++ A E+ +R+ E + LE ++
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 201 EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS--DG 258
+AER E RE K+ QLK EE+ + + +T + S D
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 259 VLD-----EQE---LEALFTKELEKVYDPKNEED-DMREMEEERLRMREHVMKNVDTNQD 309
+L EQE LE LF E+ K + E+ ++ME+ER R+
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL------------- 2548
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ ++EE R+ + EG +EEL++ E++ +E L + QRL
Sbjct: 2549 -VASMEE-----ARRRQHEAEEGVRR-------KQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKF 422
++ + L A E+ + + K + PAA E + F
Sbjct: 2596 EQLQLLEEQHRAALAHSEEVTAS--QVAATKTLPNGRDALDGPAAEAEPEHSF 2646
Score = 34.7 bits (78), Expect = 0.19
Identities = 74/331 (22%), Positives = 136/331 (41%), Gaps = 33/331 (9%)
Query: 107 EVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARD-LELLIQTATRDL 165
EV R R + ++ Q Q D ++ E L Q ++ E+ D L +Q A R
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQ--RELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
Q A + + E+ R ++L EE + E K+EE QR +++ + +
Sbjct: 1231 EQIQAMPLADSQAVR-----EQLRQEQALLEEIERHGE-KVEECQRFAKQYINA-IKDYE 1283
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE--------QELEALFTKELEKVY 277
QL +L+ + PK S+ V+ E EL L ++ ++ +
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 278 DP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E++ R E++R RE + + V+ ++ L E A + + + E + +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 337 EMHPAYTEE-------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+ EE + R +EEL A+ Q +++ EA RS+ R+E + R +
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 390 Q-QAVLHMEQRKQQQQQQQGHKAPAAHPEGQ 419
+ Q QR + + Q +A A E Q
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQ 1488
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 49/272 (18%)
Query: 189 RYLESLGEE-QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE-----------ELD 236
R + +GE Q++ ER +E ++ R R AQL E W+ EL+
Sbjct: 1154 RGAQEVGERLQQRHGERDVEVERWRERV----------AQLLERWQAVLAQTDVRQRELE 1203
Query: 237 GLDPN-RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE------- 288
L R+ ++ L D +++++A+ + + V + +E + E
Sbjct: 1204 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1263
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLE---EFLASTQRK---EFGDTGEGWETVEMHPAY 342
EE R + + + + +LVT + E +AS +K + G E V++ Y
Sbjct: 1264 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1323
Query: 343 TE-------------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+E E LRR EEE E + + +RL++ AL + + EA +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 390 QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
QA ++ +Q+ Q++ + AA Q K
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Score = 33.9 bits (76), Expect = 0.32
Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 55/366 (15%)
Query: 72 LQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAK-MDAEQDPNVQVD 130
L+ AE+ + +L+ + F + + + K RL L KA + E+ + D
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 131 HLNLLKQFEHLDPQNQHTFEAR-----DLELLIQTATRDLAQYDAAHHEEFKRYEMLK-E 184
L +Q E + +FE +LEL +L + + + + E + E
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELE 1968
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
R+R L + E +R+EAE ++++ E + Q K EE++ L
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--------QRKAALEEVERLKAK--- 2017
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
V + + L +E + E R EE+ H
Sbjct: 2018 --------------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA----HAFAVQ 2059
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
Q+ TL+ Q + D G A EE R E AA+ +
Sbjct: 2060 QKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 365 AQRLSQ--ETEALGRSQGRLEAQK--RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
A+RL Q E +A R+Q + A+K +E +Q Q +Q +Q+ +A A E
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHK 2171
Query: 421 KFHPDT 426
KF T
Sbjct: 2172 KFAEQT 2177
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 71 KLQAANAEDIKSGKLSRELDFVSHHVRTKL-DELKRQEVSRLRMLLKAKMDAEQDPNVQ- 128
+LQA A ++ R+ + +R ++ DE +R+ + + + + K +AE Q
Sbjct: 1478 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1537
Query: 129 ----VDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDL---------------AQYD 169
++ L L + + AR +++ ++TA R AQ +
Sbjct: 1538 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1597
Query: 170 AAHHEEFKRYEMLKEH-ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQL 228
+ EE L+E ERR ++ E R+EAER+LE Q + E ++ + Q
Sbjct: 1598 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-----QA 1652
Query: 229 KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+EV ++ L ++ +E E EA + E+ + RE
Sbjct: 1653 EEVAQQKS--------------LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRE 1692
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR 348
+ E+ L + + + T Q RL +E + E G E EEEL
Sbjct: 1693 LAEQELEKQRQLAEG--TAQQRLAAEQELIRLRAETEQG---------EQQRQLLEEELA 1741
Query: 349 RFEEELAA---REAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
R + E AA + EL A+ ++ E E L S+ R E + R E+ KQ+ +
Sbjct: 1742 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEA 1795
Query: 406 QQGHKAPAAHPEGQLK 421
+ G A +L+
Sbjct: 1796 EAGRFRELAEEAARLR 1811
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/417 (19%), Positives = 171/417 (41%), Gaps = 79/417 (18%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ AE ++ + +++ VR +++EL + LKA+++AE +
Sbjct: 2211 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK---------LKARIEAENRALILR 2261
Query: 130 DHLNLLKQF-EHLDPQNQHTFEARDLELLIQTATR-------DLAQYDAAHHEEFK-RYE 180
D N + E + Q EA L + Q A R DLAQ A + K + +
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2321
Query: 181 MLKEHERRRYLESLGEEQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLK-------E 230
++E R + L ++Q++ A+ R+L+E + + + G Q L+ E
Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381
Query: 231 VWEELDGL----------------DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ E + L D RF + I ++ + ++++ + T E++
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2441
Query: 275 KV---YDPKNEEDDMREMEEERLRMREHV-MKNVDTNQDRLVTLEEFLASTQRKEFGDTG 330
+ +D + + + E+E E+ ++++ + + + + + V E+ L TQ +
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2501
Query: 331 EGWETVEMHPAYTEEELRRFE--------------EELAAREAELNAKAQRLSQETEALG 376
E +++ + E+E + E EE ++ ++ + QRL E
Sbjct: 2502 EK-DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQ----------------QQGHKAPAAHPE 417
R Q E R Q+ + +EQ+++QQ++ ++ H+A AH E
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2617
Score = 42.7 bits (99), Expect = 7e-04
Identities = 88/383 (22%), Positives = 149/383 (38%), Gaps = 63/383 (16%)
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EVSRLRMLLKAKMDAEQDPNVQVDHL 132
AE +L+ E + + T+ E +RQ E++RL+ A Q+ ++ +
Sbjct: 1705 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1764
Query: 133 N-----LLKQFEHLDPQNQHTFEARDLELLIQTAT-RDLAQYDA---AHHEEFKRYEMLK 183
LL + +++ T E L + R+LA+ A A EE KR L
Sbjct: 1765 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1824
Query: 184 EHERRRY-----------LESLGEEQR-----------KEAE----RKLEEQQRRHREHP 217
E + R L ++GE R KEAE R+L E + R
Sbjct: 1825 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1884
Query: 218 KVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ--ELEALFTK---- 271
+ +A ++E +L + + + + ++E+ L+A F K
Sbjct: 1885 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1944
Query: 272 ----ELEKVYDPKNEEDDMREMEEERL---RMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
ELE N ED +R E+ L R R+ + ++ +++ LA+ + +
Sbjct: 1945 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA-EEE 2003
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
E VE A EE R L R + +A+ +L+QE +Q RL+A
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARR-----LRERAEQESARQLQLAQEA-----AQKRLQA 2053
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
+++ AV EQ QQ QQ+
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQE 2076
Score = 38.9 bits (89), Expect = 0.010
Identities = 64/257 (24%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 187 RRRYLESLGEEQRKEAERK------LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
R+R LE LG + R E L++ +RR + + + SQA +++ +E L+
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Query: 241 -NRFNPKTF----FILHDINSDGVLDEQELEALFTK-ELEKVYDPKN------------- 281
R K F IN+ + + EL+ + K +LE V P
Sbjct: 1262 IERHGEKVEECQRFAKQYINA---IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1318
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
E D+R E + +K + R+ EE LA QR E E E+ A
Sbjct: 1319 EYVDLRTHYSELTTLTSQYIKFISETLRRMEE-EERLAEQQRAE-----ERERLAEVEAA 1372
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQ--KRELQQAVLHME 397
E+ R+ E A +A+ +A+ L Q + E + R + ++AQ KR +Q+ + +
Sbjct: 1373 L--EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1430
Query: 398 QRKQQQQQQQGHKAPAA 414
Q + + Q + +A AA
Sbjct: 1431 QSSEAEIQAKARQAEAA 1447
Score = 37.7 bits (86), Expect = 0.022
Identities = 87/413 (21%), Positives = 155/413 (37%), Gaps = 73/413 (17%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ---EVS 109
R+LQE + ++ +L A E + +L+ E + K+ + K Q E +
Sbjct: 2268 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2327
Query: 110 RLR-----MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA---RDLELL---- 157
RL+ + + ++ EQ +Q D + +Q Q T EA R LE+
Sbjct: 2328 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2387
Query: 158 -IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRY----------------LESLGEEQRK 200
++ ++++ A E+ +R+ E + LE ++
Sbjct: 2388 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2447
Query: 201 EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS--DG 258
+AER E RE K+ QLK EE+ + + +T + S D
Sbjct: 2448 DAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQTVQQEQLLQETQALQQSFLSEKDS 2505
Query: 259 VLD-----EQE---LEALFTKELEKVYDPKNEED-DMREMEEERLRMREHVMKNVDTNQD 309
+L EQE LE LF E+ K + E+ ++ME+ER R+
Sbjct: 2506 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL------------- 2552
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ ++EE R+ + EG +EEL++ E++ +E L + QRL
Sbjct: 2553 -VASMEE-----ARRRQHEAEEGVRR-------KQEELQQLEQQRRQQEELLAEENQRLR 2599
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKF 422
++ + L A E+ + + K + PAA E + F
Sbjct: 2600 EQLQLLEEQHRAALAHSEEVTAS--QVAATKTLPNGRDALDGPAAEAEPEHSF 2650
Score = 34.7 bits (78), Expect = 0.19
Identities = 74/331 (22%), Positives = 136/331 (41%), Gaps = 33/331 (9%)
Query: 107 EVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARD-LELLIQTATRDL 165
EV R R + ++ Q Q D ++ E L Q ++ E+ D L +Q A R
Sbjct: 1177 EVERWRERVAQLLERWQAVLAQTDVRQ--RELEQLGRQLRYYRESADPLGAWLQDARRRQ 1234
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
Q A + + E+ R ++L EE + E K+EE QR +++ + +
Sbjct: 1235 EQIQAMPLADSQAVR-----EQLRQEQALLEEIERHGE-KVEECQRFAKQYINA-IKDYE 1287
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE--------QELEALFTKELEKVY 277
QL +L+ + PK S+ V+ E EL L ++ ++ +
Sbjct: 1288 LQLVTYKAQLEPVASPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1342
Query: 278 DP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E++ R E++R RE + + V+ ++ L E A + + + E + +
Sbjct: 1343 ETLRRMEEEERLAEQQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401
Query: 337 EMHPAYTEE-------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+ EE + R +EEL A+ Q +++ EA RS+ R+E + R +
Sbjct: 1402 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1461
Query: 390 Q-QAVLHMEQRKQQQQQQQGHKAPAAHPEGQ 419
+ Q QR + + Q +A A E Q
Sbjct: 1462 RLQLEATERQRGGAEGELQALRARAEEAEAQ 1492
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 49/272 (18%)
Query: 189 RYLESLGEE-QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE-----------ELD 236
R + +GE Q++ ER +E ++ R R AQL E W+ EL+
Sbjct: 1158 RGAQEVGERLQQRHGERDVEVERWRERV----------AQLLERWQAVLAQTDVRQRELE 1207
Query: 237 GLDPN-RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE------- 288
L R+ ++ L D +++++A+ + + V + +E + E
Sbjct: 1208 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1267
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLE---EFLASTQRK---EFGDTGEGWETVEMHPAY 342
EE R + + + + +LVT + E +AS +K + G E V++ Y
Sbjct: 1268 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1327
Query: 343 TE-------------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+E E LRR EEE E + + +RL++ AL + + EA +
Sbjct: 1328 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1387
Query: 390 QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
QA ++ +Q+ Q++ + AA Q K
Sbjct: 1388 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1419
Score = 33.9 bits (76), Expect = 0.32
Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 55/366 (15%)
Query: 72 LQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAK-MDAEQDPNVQVD 130
L+ AE+ + +L+ + F + + + K RL L KA + E+ + D
Sbjct: 1860 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1919
Query: 131 HLNLLKQFEHLDPQNQHTFEAR-----DLELLIQTATRDLAQYDAAHHEEFKRYEMLK-E 184
L +Q E + +FE +LEL +L + + + + E + E
Sbjct: 1920 TLRQRRQVEEEILALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELE 1972
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
R+R L + E +R+EAE ++++ E + Q K EE++ L
Sbjct: 1973 AARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--------QRKAALEEVERLKAK--- 2021
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
V + + L +E + E R EE+ H
Sbjct: 2022 --------------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA----HAFAVQ 2063
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
Q+ TL+ Q + D G A EE R E AA+ +
Sbjct: 2064 QKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2117
Query: 365 AQRLSQ--ETEALGRSQGRLEAQK--RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
A+RL Q E +A R+Q + A+K +E +Q Q +Q +Q+ +A A E
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHK 2175
Query: 421 KFHPDT 426
KF T
Sbjct: 2176 KFAEQT 2181
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 71 KLQAANAEDIKSGKLSRELDFVSHHVRTKL-DELKRQEVSRLRMLLKAKMDAEQDPNVQ- 128
+LQA A ++ R+ + +R ++ DE +R+ + + + + K +AE Q
Sbjct: 1474 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1533
Query: 129 ----VDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDL---------------AQYD 169
++ L L + + AR +++ ++TA R AQ +
Sbjct: 1534 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1593
Query: 170 AAHHEEFKRYEMLKEH-ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQL 228
+ EE L+E ERR ++ E R+EAER+LE Q + E ++ + Q
Sbjct: 1594 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-----QA 1648
Query: 229 KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+EV ++ L ++ +E E EA + E+ + RE
Sbjct: 1649 EEVAQQKS--------------LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRE 1688
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR 348
+ E+ L + + + T Q RL +E + E G E EEEL
Sbjct: 1689 LAEQELEKQRQLAEG--TAQQRLAAEQELIRLRAETEQG---------EQQRQLLEEELA 1737
Query: 349 RFEEELAA---REAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
R + E AA + EL A+ ++ E E L S+ R E + R E+ KQ+ +
Sbjct: 1738 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEA 1791
Query: 406 QQGHKAPAAHPEGQLK 421
+ G A +L+
Sbjct: 1792 EAGRFRELAEEAARLR 1807
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/417 (19%), Positives = 171/417 (41%), Gaps = 79/417 (18%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ AE ++ + +++ VR +++EL + LKA+++AE +
Sbjct: 2207 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK---------LKARIEAENRALILR 2257
Query: 130 DHLNLLKQF-EHLDPQNQHTFEARDLELLIQTATR-------DLAQYDAAHHEEFK-RYE 180
D N + E + Q EA L + Q A R DLAQ A + K + +
Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317
Query: 181 MLKEHERRRYLESLGEEQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLK-------E 230
++E R + L ++Q++ A+ R+L+E + + + G Q L+ E
Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377
Query: 231 VWEELDGL----------------DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ E + L D RF + I ++ + ++++ + T E++
Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437
Query: 275 KV---YDPKNEEDDMREMEEERLRMREHV-MKNVDTNQDRLVTLEEFLASTQRKEFGDTG 330
+ +D + + + E+E E+ ++++ + + + + + V E+ L TQ +
Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497
Query: 331 EGWETVEMHPAYTEEELRRFE--------------EELAAREAELNAKAQRLSQETEALG 376
E +++ + E+E + E EE ++ ++ + QRL E
Sbjct: 2498 EK-DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQ----------------QQGHKAPAAHPE 417
R Q E R Q+ + +EQ+++QQ++ ++ H+A AH E
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2613
Score = 42.7 bits (99), Expect = 7e-04
Identities = 88/383 (22%), Positives = 149/383 (38%), Gaps = 63/383 (16%)
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EVSRLRMLLKAKMDAEQDPNVQVDHL 132
AE +L+ E + + T+ E +RQ E++RL+ A Q+ ++ +
Sbjct: 1701 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1760
Query: 133 N-----LLKQFEHLDPQNQHTFEARDLELLIQTAT-RDLAQYDA---AHHEEFKRYEMLK 183
LL + +++ T E L + R+LA+ A A EE KR L
Sbjct: 1761 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1820
Query: 184 EHERRRY-----------LESLGEEQR-----------KEAE----RKLEEQQRRHREHP 217
E + R L ++GE R KEAE R+L E + R
Sbjct: 1821 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1880
Query: 218 KVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ--ELEALFTK---- 271
+ +A ++E +L + + + + ++E+ L+A F K
Sbjct: 1881 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1940
Query: 272 ----ELEKVYDPKNEEDDMREMEEERL---RMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
ELE N ED +R E+ L R R+ + ++ +++ LA+ + +
Sbjct: 1941 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA-EEE 1999
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
E VE A EE R L R + +A+ +L+QE +Q RL+A
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARR-----LRERAEQESARQLQLAQEA-----AQKRLQA 2049
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
+++ AV EQ QQ QQ+
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQE 2072
Score = 38.9 bits (89), Expect = 0.010
Identities = 64/257 (24%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 187 RRRYLESLGEEQRKEAERK------LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
R+R LE LG + R E L++ +RR + + + SQA +++ +E L+
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 241 -NRFNPKTF----FILHDINSDGVLDEQELEALFTK-ELEKVYDPKN------------- 281
R K F IN+ + + EL+ + K +LE V P
Sbjct: 1258 IERHGEKVEECQRFAKQYINA---IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1314
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
E D+R E + +K + R+ EE LA QR E E E+ A
Sbjct: 1315 EYVDLRTHYSELTTLTSQYIKFISETLRRMEE-EERLAEQQRAE-----ERERLAEVEAA 1368
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQ--KRELQQAVLHME 397
E+ R+ E A +A+ +A+ L Q + E + R + ++AQ KR +Q+ + +
Sbjct: 1369 L--EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1426
Query: 398 QRKQQQQQQQGHKAPAA 414
Q + + Q + +A AA
Sbjct: 1427 QSSEAEIQAKARQAEAA 1443
Score = 37.7 bits (86), Expect = 0.022
Identities = 87/413 (21%), Positives = 155/413 (37%), Gaps = 73/413 (17%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ---EVS 109
R+LQE + ++ +L A E + +L+ E + K+ + K Q E +
Sbjct: 2264 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2323
Query: 110 RLR-----MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA---RDLELL---- 157
RL+ + + ++ EQ +Q D + +Q Q T EA R LE+
Sbjct: 2324 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2383
Query: 158 -IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRY----------------LESLGEEQRK 200
++ ++++ A E+ +R+ E + LE ++
Sbjct: 2384 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2443
Query: 201 EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS--DG 258
+AER E RE K+ QLK EE+ + + +T + S D
Sbjct: 2444 DAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQTVQQEQLLQETQALQQSFLSEKDS 2501
Query: 259 VLD-----EQE---LEALFTKELEKVYDPKNEED-DMREMEEERLRMREHVMKNVDTNQD 309
+L EQE LE LF E+ K + E+ ++ME+ER R+
Sbjct: 2502 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL------------- 2548
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ ++EE R+ + EG +EEL++ E++ +E L + QRL
Sbjct: 2549 -VASMEE-----ARRRQHEAEEGVRR-------KQEELQQLEQQRRQQEELLAEENQRLR 2595
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKF 422
++ + L A E+ + + K + PAA E + F
Sbjct: 2596 EQLQLLEEQHRAALAHSEEVTAS--QVAATKTLPNGRDALDGPAAEAEPEHSF 2646
Score = 34.7 bits (78), Expect = 0.19
Identities = 74/331 (22%), Positives = 136/331 (41%), Gaps = 33/331 (9%)
Query: 107 EVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARD-LELLIQTATRDL 165
EV R R + ++ Q Q D ++ E L Q ++ E+ D L +Q A R
Sbjct: 1173 EVERWRERVAQLLERWQAVLAQTDVRQ--RELEQLGRQLRYYRESADPLGAWLQDARRRQ 1230
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
Q A + + E+ R ++L EE + E K+EE QR +++ + +
Sbjct: 1231 EQIQAMPLADSQAVR-----EQLRQEQALLEEIERHGE-KVEECQRFAKQYINA-IKDYE 1283
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE--------QELEALFTKELEKVY 277
QL +L+ + PK S+ V+ E EL L ++ ++ +
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 278 DP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E++ R E++R RE + + V+ ++ L E A + + + E + +
Sbjct: 1339 ETLRRMEEEERLAEQQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 337 EMHPAYTEE-------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+ EE + R +EEL A+ Q +++ EA RS+ R+E + R +
Sbjct: 1398 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1457
Query: 390 Q-QAVLHMEQRKQQQQQQQGHKAPAAHPEGQ 419
+ Q QR + + Q +A A E Q
Sbjct: 1458 RLQLEATERQRGGAEGELQALRARAEEAEAQ 1488
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 49/272 (18%)
Query: 189 RYLESLGEE-QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE-----------ELD 236
R + +GE Q++ ER +E ++ R R AQL E W+ EL+
Sbjct: 1154 RGAQEVGERLQQRHGERDVEVERWRERV----------AQLLERWQAVLAQTDVRQRELE 1203
Query: 237 GLDPN-RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE------- 288
L R+ ++ L D +++++A+ + + V + +E + E
Sbjct: 1204 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1263
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLE---EFLASTQRK---EFGDTGEGWETVEMHPAY 342
EE R + + + + +LVT + E +AS +K + G E V++ Y
Sbjct: 1264 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1323
Query: 343 TE-------------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+E E LRR EEE E + + +RL++ AL + + EA +
Sbjct: 1324 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1383
Query: 390 QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
QA ++ +Q+ Q++ + AA Q K
Sbjct: 1384 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1415
Score = 33.9 bits (76), Expect = 0.32
Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 55/366 (15%)
Query: 72 LQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAK-MDAEQDPNVQVD 130
L+ AE+ + +L+ + F + + + K RL L KA + E+ + D
Sbjct: 1856 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1915
Query: 131 HLNLLKQFEHLDPQNQHTFEAR-----DLELLIQTATRDLAQYDAAHHEEFKRYEMLK-E 184
L +Q E + +FE +LEL +L + + + + E + E
Sbjct: 1916 TLRQRRQVEEEILALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELE 1968
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
R+R L + E +R+EAE ++++ E + Q K EE++ L
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--------QRKAALEEVERLKAK--- 2017
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
V + + L +E + E R EE+ H
Sbjct: 2018 --------------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA----HAFAVQ 2059
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
Q+ TL+ Q + D G A EE R E AA+ +
Sbjct: 2060 QKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 365 AQRLSQ--ETEALGRSQGRLEAQK--RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
A+RL Q E +A R+Q + A+K +E +Q Q +Q +Q+ +A A E
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHK 2171
Query: 421 KFHPDT 426
KF T
Sbjct: 2172 KFAEQT 2177
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 71 KLQAANAEDIKSGKLSRELDFVSHHVRTKL-DELKRQEVSRLRMLLKAKMDAEQDPNVQ- 128
+LQA A ++ R+ + +R ++ DE +R+ + + + + K +AE Q
Sbjct: 1442 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1501
Query: 129 ----VDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDL---------------AQYD 169
++ L L + + AR +++ ++TA R AQ +
Sbjct: 1502 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1561
Query: 170 AAHHEEFKRYEMLKEH-ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQL 228
+ EE L+E ERR ++ E R+EAER+LE Q + E ++ + Q
Sbjct: 1562 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-----QA 1616
Query: 229 KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+EV ++ L ++ +E E EA + E+ + RE
Sbjct: 1617 EEVAQQKS--------------LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRE 1656
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR 348
+ E+ L + + + T Q RL +E + E G E EEEL
Sbjct: 1657 LAEQELEKQRQLAEG--TAQQRLAAEQELIRLRAETEQG---------EQQRQLLEEELA 1705
Query: 349 RFEEELAA---REAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
R + E AA + EL A+ ++ E E L S+ R E + R E+ KQ+ +
Sbjct: 1706 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEA 1759
Query: 406 QQGHKAPAAHPEGQLK 421
+ G A +L+
Sbjct: 1760 EAGRFRELAEEAARLR 1775
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/417 (19%), Positives = 171/417 (41%), Gaps = 79/417 (18%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ AE ++ + +++ VR +++EL + LKA+++AE +
Sbjct: 2175 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK---------LKARIEAENRALILR 2225
Query: 130 DHLNLLKQF-EHLDPQNQHTFEARDLELLIQTATR-------DLAQYDAAHHEEFK-RYE 180
D N + E + Q EA L + Q A R DLAQ A + K + +
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2285
Query: 181 MLKEHERRRYLESLGEEQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLK-------E 230
++E R + L ++Q++ A+ R+L+E + + + G Q L+ E
Sbjct: 2286 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345
Query: 231 VWEELDGL----------------DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ E + L D RF + I ++ + ++++ + T E++
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2405
Query: 275 KV---YDPKNEEDDMREMEEERLRMREHV-MKNVDTNQDRLVTLEEFLASTQRKEFGDTG 330
+ +D + + + E+E E+ ++++ + + + + + V E+ L TQ +
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2465
Query: 331 EGWETVEMHPAYTEEELRRFE--------------EELAAREAELNAKAQRLSQETEALG 376
E +++ + E+E + E EE ++ ++ + QRL E
Sbjct: 2466 EK-DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQ----------------QQGHKAPAAHPE 417
R Q E R Q+ + +EQ+++QQ++ ++ H+A AH E
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2581
Score = 42.7 bits (99), Expect = 7e-04
Identities = 88/383 (22%), Positives = 149/383 (38%), Gaps = 63/383 (16%)
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EVSRLRMLLKAKMDAEQDPNVQVDHL 132
AE +L+ E + + T+ E +RQ E++RL+ A Q+ ++ +
Sbjct: 1669 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1728
Query: 133 N-----LLKQFEHLDPQNQHTFEARDLELLIQTAT-RDLAQYDA---AHHEEFKRYEMLK 183
LL + +++ T E L + R+LA+ A A EE KR L
Sbjct: 1729 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1788
Query: 184 EHERRRY-----------LESLGEEQR-----------KEAE----RKLEEQQRRHREHP 217
E + R L ++GE R KEAE R+L E + R
Sbjct: 1789 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1848
Query: 218 KVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ--ELEALFTK---- 271
+ +A ++E +L + + + + ++E+ L+A F K
Sbjct: 1849 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1908
Query: 272 ----ELEKVYDPKNEEDDMREMEEERL---RMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
ELE N ED +R E+ L R R+ + ++ +++ LA+ + +
Sbjct: 1909 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA-EEE 1967
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
E VE A EE R L R + +A+ +L+QE +Q RL+A
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARR-----LRERAEQESARQLQLAQEA-----AQKRLQA 2017
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
+++ AV EQ QQ QQ+
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQE 2040
Score = 38.9 bits (89), Expect = 0.010
Identities = 64/257 (24%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 187 RRRYLESLGEEQRKEAERK------LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
R+R LE LG + R E L++ +RR + + + SQA +++ +E L+
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Query: 241 -NRFNPKTF----FILHDINSDGVLDEQELEALFTK-ELEKVYDPKN------------- 281
R K F IN+ + + EL+ + K +LE V P
Sbjct: 1226 IERHGEKVEECQRFAKQYINA---IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1282
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
E D+R E + +K + R+ EE LA QR E E E+ A
Sbjct: 1283 EYVDLRTHYSELTTLTSQYIKFISETLRRMEE-EERLAEQQRAE-----ERERLAEVEAA 1336
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQ--KRELQQAVLHME 397
E+ R+ E A +A+ +A+ L Q + E + R + ++AQ KR +Q+ + +
Sbjct: 1337 L--EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1394
Query: 398 QRKQQQQQQQGHKAPAA 414
Q + + Q + +A AA
Sbjct: 1395 QSSEAEIQAKARQAEAA 1411
Score = 37.7 bits (86), Expect = 0.022
Identities = 87/413 (21%), Positives = 155/413 (37%), Gaps = 73/413 (17%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ---EVS 109
R+LQE + ++ +L A E + +L+ E + K+ + K Q E +
Sbjct: 2232 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2291
Query: 110 RLR-----MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA---RDLELL---- 157
RL+ + + ++ EQ +Q D + +Q Q T EA R LE+
Sbjct: 2292 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2351
Query: 158 -IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRY----------------LESLGEEQRK 200
++ ++++ A E+ +R+ E + LE ++
Sbjct: 2352 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2411
Query: 201 EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS--DG 258
+AER E RE K+ QLK EE+ + + +T + S D
Sbjct: 2412 DAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQTVQQEQLLQETQALQQSFLSEKDS 2469
Query: 259 VLD-----EQE---LEALFTKELEKVYDPKNEED-DMREMEEERLRMREHVMKNVDTNQD 309
+L EQE LE LF E+ K + E+ ++ME+ER R+
Sbjct: 2470 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL------------- 2516
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ ++EE R+ + EG +EEL++ E++ +E L + QRL
Sbjct: 2517 -VASMEE-----ARRRQHEAEEGVRR-------KQEELQQLEQQRRQQEELLAEENQRLR 2563
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKF 422
++ + L A E+ + + K + PAA E + F
Sbjct: 2564 EQLQLLEEQHRAALAHSEEVTAS--QVAATKTLPNGRDALDGPAAEAEPEHSF 2614
Score = 34.7 bits (78), Expect = 0.19
Identities = 74/331 (22%), Positives = 136/331 (41%), Gaps = 33/331 (9%)
Query: 107 EVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARD-LELLIQTATRDL 165
EV R R + ++ Q Q D ++ E L Q ++ E+ D L +Q A R
Sbjct: 1141 EVERWRERVAQLLERWQAVLAQTDVRQ--RELEQLGRQLRYYRESADPLGAWLQDARRRQ 1198
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
Q A + + E+ R ++L EE + E K+EE QR +++ + +
Sbjct: 1199 EQIQAMPLADSQAVR-----EQLRQEQALLEEIERHGE-KVEECQRFAKQYINA-IKDYE 1251
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE--------QELEALFTKELEKVY 277
QL +L+ + PK S+ V+ E EL L ++ ++ +
Sbjct: 1252 LQLVTYKAQLEPVASPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1306
Query: 278 DP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E++ R E++R RE + + V+ ++ L E A + + + E + +
Sbjct: 1307 ETLRRMEEEERLAEQQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365
Query: 337 EMHPAYTEE-------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+ EE + R +EEL A+ Q +++ EA RS+ R+E + R +
Sbjct: 1366 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1425
Query: 390 Q-QAVLHMEQRKQQQQQQQGHKAPAAHPEGQ 419
+ Q QR + + Q +A A E Q
Sbjct: 1426 RLQLEATERQRGGAEGELQALRARAEEAEAQ 1456
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 49/272 (18%)
Query: 189 RYLESLGEE-QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE-----------ELD 236
R + +GE Q++ ER +E ++ R R AQL E W+ EL+
Sbjct: 1122 RGAQEVGERLQQRHGERDVEVERWRERV----------AQLLERWQAVLAQTDVRQRELE 1171
Query: 237 GLDPN-RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE------- 288
L R+ ++ L D +++++A+ + + V + +E + E
Sbjct: 1172 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1231
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLE---EFLASTQRK---EFGDTGEGWETVEMHPAY 342
EE R + + + + +LVT + E +AS +K + G E V++ Y
Sbjct: 1232 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1291
Query: 343 TE-------------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+E E LRR EEE E + + +RL++ AL + + EA +
Sbjct: 1292 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1351
Query: 390 QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
QA ++ +Q+ Q++ + AA Q K
Sbjct: 1352 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1383
Score = 33.9 bits (76), Expect = 0.32
Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 55/366 (15%)
Query: 72 LQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAK-MDAEQDPNVQVD 130
L+ AE+ + +L+ + F + + + K RL L KA + E+ + D
Sbjct: 1824 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1883
Query: 131 HLNLLKQFEHLDPQNQHTFEAR-----DLELLIQTATRDLAQYDAAHHEEFKRYEMLK-E 184
L +Q E + +FE +LEL +L + + + + E + E
Sbjct: 1884 TLRQRRQVEEEILALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELE 1936
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
R+R L + E +R+EAE ++++ E + Q K EE++ L
Sbjct: 1937 AARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--------QRKAALEEVERLKAK--- 1985
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
V + + L +E + E R EE+ H
Sbjct: 1986 --------------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA----HAFAVQ 2027
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
Q+ TL+ Q + D G A EE R E AA+ +
Sbjct: 2028 QKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2081
Query: 365 AQRLSQ--ETEALGRSQGRLEAQK--RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
A+RL Q E +A R+Q + A+K +E +Q Q +Q +Q+ +A A E
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHK 2139
Query: 421 KFHPDT 426
KF T
Sbjct: 2140 KFAEQT 2145
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 71 KLQAANAEDIKSGKLSRELDFVSHHVRTKL-DELKRQEVSRLRMLLKAKMDAEQDPNVQ- 128
+LQA A ++ R+ + +R ++ DE +R+ + + + + K +AE Q
Sbjct: 1611 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1670
Query: 129 ----VDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDL---------------AQYD 169
++ L L + + AR +++ ++TA R AQ +
Sbjct: 1671 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730
Query: 170 AAHHEEFKRYEMLKEH-ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQL 228
+ EE L+E ERR ++ E R+EAER+LE Q + E ++ + Q
Sbjct: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-----QA 1785
Query: 229 KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+EV ++ L ++ +E E EA + E+ + RE
Sbjct: 1786 EEVAQQKS--------------LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRE 1825
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR 348
+ E+ L + + + T Q RL +E + E G E EEEL
Sbjct: 1826 LAEQELEKQRQLAEG--TAQQRLAAEQELIRLRAETEQG---------EQQRQLLEEELA 1874
Query: 349 RFEEELAA---REAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
R + E AA + EL A+ ++ E E L S+ R E + R E+ KQ+ +
Sbjct: 1875 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEA 1928
Query: 406 QQGHKAPAAHPEGQLK 421
+ G A +L+
Sbjct: 1929 EAGRFRELAEEAARLR 1944
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/417 (19%), Positives = 171/417 (41%), Gaps = 79/417 (18%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ AE ++ + +++ VR +++EL + LKA+++AE +
Sbjct: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK---------LKARIEAENRALILR 2394
Query: 130 DHLNLLKQF-EHLDPQNQHTFEARDLELLIQTATR-------DLAQYDAAHHEEFK-RYE 180
D N + E + Q EA L + Q A R DLAQ A + K + +
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454
Query: 181 MLKEHERRRYLESLGEEQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLK-------E 230
++E R + L ++Q++ A+ R+L+E + + + G Q L+ E
Sbjct: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514
Query: 231 VWEELDGL----------------DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ E + L D RF + I ++ + ++++ + T E++
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574
Query: 275 KV---YDPKNEEDDMREMEEERLRMREHV-MKNVDTNQDRLVTLEEFLASTQRKEFGDTG 330
+ +D + + + E+E E+ ++++ + + + + + V E+ L TQ +
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634
Query: 331 EGWETVEMHPAYTEEELRRFE--------------EELAAREAELNAKAQRLSQETEALG 376
E +++ + E+E + E EE ++ ++ + QRL E
Sbjct: 2635 EK-DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQ----------------QQGHKAPAAHPE 417
R Q E R Q+ + +EQ+++QQ++ ++ H+A AH E
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2750
Score = 42.7 bits (99), Expect = 7e-04
Identities = 88/383 (22%), Positives = 149/383 (38%), Gaps = 63/383 (16%)
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EVSRLRMLLKAKMDAEQDPNVQVDHL 132
AE +L+ E + + T+ E +RQ E++RL+ A Q+ ++ +
Sbjct: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1897
Query: 133 N-----LLKQFEHLDPQNQHTFEARDLELLIQTAT-RDLAQYDA---AHHEEFKRYEMLK 183
LL + +++ T E L + R+LA+ A A EE KR L
Sbjct: 1898 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1957
Query: 184 EHERRRY-----------LESLGEEQR-----------KEAE----RKLEEQQRRHREHP 217
E + R L ++GE R KEAE R+L E + R
Sbjct: 1958 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 2017
Query: 218 KVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ--ELEALFTK---- 271
+ +A ++E +L + + + + ++E+ L+A F K
Sbjct: 2018 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 2077
Query: 272 ----ELEKVYDPKNEEDDMREMEEERL---RMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
ELE N ED +R E+ L R R+ + ++ +++ LA+ + +
Sbjct: 2078 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA-EEE 2136
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
E VE A EE R L R + +A+ +L+QE +Q RL+A
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARR-----LRERAEQESARQLQLAQEA-----AQKRLQA 2186
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
+++ AV EQ QQ QQ+
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQE 2209
Score = 38.9 bits (89), Expect = 0.010
Identities = 64/257 (24%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 187 RRRYLESLGEEQRKEAERK------LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
R+R LE LG + R E L++ +RR + + + SQA +++ +E L+
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Query: 241 -NRFNPKTF----FILHDINSDGVLDEQELEALFTK-ELEKVYDPKN------------- 281
R K F IN+ + + EL+ + K +LE V P
Sbjct: 1395 IERHGEKVEECQRFAKQYINA---IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1451
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
E D+R E + +K + R+ EE LA QR E E E+ A
Sbjct: 1452 EYVDLRTHYSELTTLTSQYIKFISETLRRMEE-EERLAEQQRAE-----ERERLAEVEAA 1505
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQ--KRELQQAVLHME 397
E+ R+ E A +A+ +A+ L Q + E + R + ++AQ KR +Q+ + +
Sbjct: 1506 L--EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1563
Query: 398 QRKQQQQQQQGHKAPAA 414
Q + + Q + +A AA
Sbjct: 1564 QSSEAEIQAKARQAEAA 1580
Score = 37.7 bits (86), Expect = 0.022
Identities = 87/413 (21%), Positives = 155/413 (37%), Gaps = 73/413 (17%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ---EVS 109
R+LQE + ++ +L A E + +L+ E + K+ + K Q E +
Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460
Query: 110 RLR-----MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA---RDLELL---- 157
RL+ + + ++ EQ +Q D + +Q Q T EA R LE+
Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520
Query: 158 -IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRY----------------LESLGEEQRK 200
++ ++++ A E+ +R+ E + LE ++
Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580
Query: 201 EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS--DG 258
+AER E RE K+ QLK EE+ + + +T + S D
Sbjct: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQTVQQEQLLQETQALQQSFLSEKDS 2638
Query: 259 VLD-----EQE---LEALFTKELEKVYDPKNEED-DMREMEEERLRMREHVMKNVDTNQD 309
+L EQE LE LF E+ K + E+ ++ME+ER R+
Sbjct: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL------------- 2685
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ ++EE R+ + EG +EEL++ E++ +E L + QRL
Sbjct: 2686 -VASMEE-----ARRRQHEAEEGVRR-------KQEELQQLEQQRRQQEELLAEENQRLR 2732
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKF 422
++ + L A E+ + + K + PAA E + F
Sbjct: 2733 EQLQLLEEQHRAALAHSEEVTAS--QVAATKTLPNGRDALDGPAAEAEPEHSF 2783
Score = 34.7 bits (78), Expect = 0.19
Identities = 74/331 (22%), Positives = 136/331 (41%), Gaps = 33/331 (9%)
Query: 107 EVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARD-LELLIQTATRDL 165
EV R R + ++ Q Q D ++ E L Q ++ E+ D L +Q A R
Sbjct: 1310 EVERWRERVAQLLERWQAVLAQTDVRQ--RELEQLGRQLRYYRESADPLGAWLQDARRRQ 1367
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
Q A + + E+ R ++L EE + E K+EE QR +++ + +
Sbjct: 1368 EQIQAMPLADSQAVR-----EQLRQEQALLEEIERHGE-KVEECQRFAKQYINA-IKDYE 1420
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE--------QELEALFTKELEKVY 277
QL +L+ + PK S+ V+ E EL L ++ ++ +
Sbjct: 1421 LQLVTYKAQLEPVASPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475
Query: 278 DP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E++ R E++R RE + + V+ ++ L E A + + + E + +
Sbjct: 1476 ETLRRMEEEERLAEQQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534
Query: 337 EMHPAYTEE-------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+ EE + R +EEL A+ Q +++ EA RS+ R+E + R +
Sbjct: 1535 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1594
Query: 390 Q-QAVLHMEQRKQQQQQQQGHKAPAAHPEGQ 419
+ Q QR + + Q +A A E Q
Sbjct: 1595 RLQLEATERQRGGAEGELQALRARAEEAEAQ 1625
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 49/272 (18%)
Query: 189 RYLESLGEE-QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE-----------ELD 236
R + +GE Q++ ER +E ++ R R AQL E W+ EL+
Sbjct: 1291 RGAQEVGERLQQRHGERDVEVERWRERV----------AQLLERWQAVLAQTDVRQRELE 1340
Query: 237 GLDPN-RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE------- 288
L R+ ++ L D +++++A+ + + V + +E + E
Sbjct: 1341 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1400
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLE---EFLASTQRK---EFGDTGEGWETVEMHPAY 342
EE R + + + + +LVT + E +AS +K + G E V++ Y
Sbjct: 1401 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1460
Query: 343 TE-------------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+E E LRR EEE E + + +RL++ AL + + EA +
Sbjct: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1520
Query: 390 QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
QA ++ +Q+ Q++ + AA Q K
Sbjct: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1552
Score = 33.9 bits (76), Expect = 0.32
Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 55/366 (15%)
Query: 72 LQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAK-MDAEQDPNVQVD 130
L+ AE+ + +L+ + F + + + K RL L KA + E+ + D
Sbjct: 1993 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 2052
Query: 131 HLNLLKQFEHLDPQNQHTFEAR-----DLELLIQTATRDLAQYDAAHHEEFKRYEMLK-E 184
L +Q E + +FE +LEL +L + + + + E + E
Sbjct: 2053 TLRQRRQVEEEILALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELE 2105
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
R+R L + E +R+EAE ++++ E + Q K EE++ L
Sbjct: 2106 AARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--------QRKAALEEVERLKAK--- 2154
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
V + + L +E + E R EE+ H
Sbjct: 2155 --------------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA----HAFAVQ 2196
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
Q+ TL+ Q + D G A EE R E AA+ +
Sbjct: 2197 QKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2250
Query: 365 AQRLSQ--ETEALGRSQGRLEAQK--RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
A+RL Q E +A R+Q + A+K +E +Q Q +Q +Q+ +A A E
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHK 2308
Query: 421 KFHPDT 426
KF T
Sbjct: 2309 KFAEQT 2314
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 71 KLQAANAEDIKSGKLSRELDFVSHHVRTKL-DELKRQEVSRLRMLLKAKMDAEQDPNVQ- 128
+LQA A ++ R+ + +R ++ DE +R+ + + + + K +AE Q
Sbjct: 1452 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1511
Query: 129 ----VDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDL---------------AQYD 169
++ L L + + AR +++ ++TA R AQ +
Sbjct: 1512 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
Query: 170 AAHHEEFKRYEMLKEH-ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQL 228
+ EE L+E ERR ++ E R+EAER+LE Q + E ++ + Q
Sbjct: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-----QA 1626
Query: 229 KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+EV ++ L ++ +E E EA + E+ + RE
Sbjct: 1627 EEVAQQKS--------------LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRE 1666
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR 348
+ E+ L + + + T Q RL +E + E G E EEEL
Sbjct: 1667 LAEQELEKQRQLAEG--TAQQRLAAEQELIRLRAETEQG---------EQQRQLLEEELA 1715
Query: 349 RFEEELAA---REAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
R + E AA + EL A+ ++ E E L S+ R E + R E+ KQ+ +
Sbjct: 1716 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEA 1769
Query: 406 QQGHKAPAAHPEGQLK 421
+ G A +L+
Sbjct: 1770 EAGRFRELAEEAARLR 1785
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/417 (19%), Positives = 171/417 (41%), Gaps = 79/417 (18%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ AE ++ + +++ VR +++EL + LKA+++AE +
Sbjct: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK---------LKARIEAENRALILR 2235
Query: 130 DHLNLLKQF-EHLDPQNQHTFEARDLELLIQTATR-------DLAQYDAAHHEEFK-RYE 180
D N + E + Q EA L + Q A R DLAQ A + K + +
Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295
Query: 181 MLKEHERRRYLESLGEEQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLK-------E 230
++E R + L ++Q++ A+ R+L+E + + + G Q L+ E
Sbjct: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355
Query: 231 VWEELDGL----------------DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ E + L D RF + I ++ + ++++ + T E++
Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415
Query: 275 KV---YDPKNEEDDMREMEEERLRMREHV-MKNVDTNQDRLVTLEEFLASTQRKEFGDTG 330
+ +D + + + E+E E+ ++++ + + + + + V E+ L TQ +
Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475
Query: 331 EGWETVEMHPAYTEEELRRFE--------------EELAAREAELNAKAQRLSQETEALG 376
E +++ + E+E + E EE ++ ++ + QRL E
Sbjct: 2476 EK-DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQ----------------QQGHKAPAAHPE 417
R Q E R Q+ + +EQ+++QQ++ ++ H+A AH E
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2591
Score = 42.7 bits (99), Expect = 7e-04
Identities = 88/383 (22%), Positives = 149/383 (38%), Gaps = 63/383 (16%)
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EVSRLRMLLKAKMDAEQDPNVQVDHL 132
AE +L+ E + + T+ E +RQ E++RL+ A Q+ ++ +
Sbjct: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1738
Query: 133 N-----LLKQFEHLDPQNQHTFEARDLELLIQTAT-RDLAQYDA---AHHEEFKRYEMLK 183
LL + +++ T E L + R+LA+ A A EE KR L
Sbjct: 1739 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1798
Query: 184 EHERRRY-----------LESLGEEQR-----------KEAE----RKLEEQQRRHREHP 217
E + R L ++GE R KEAE R+L E + R
Sbjct: 1799 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1858
Query: 218 KVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ--ELEALFTK---- 271
+ +A ++E +L + + + + ++E+ L+A F K
Sbjct: 1859 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1918
Query: 272 ----ELEKVYDPKNEEDDMREMEEERL---RMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
ELE N ED +R E+ L R R+ + ++ +++ LA+ + +
Sbjct: 1919 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA-EEE 1977
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
E VE A EE R L R + +A+ +L+QE +Q RL+A
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARR-----LRERAEQESARQLQLAQEA-----AQKRLQA 2027
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
+++ AV EQ QQ QQ+
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQE 2050
Score = 38.9 bits (89), Expect = 0.010
Identities = 64/257 (24%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 187 RRRYLESLGEEQRKEAERK------LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
R+R LE LG + R E L++ +RR + + + SQA +++ +E L+
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Query: 241 -NRFNPKTF----FILHDINSDGVLDEQELEALFTK-ELEKVYDPKN------------- 281
R K F IN+ + + EL+ + K +LE V P
Sbjct: 1236 IERHGEKVEECQRFAKQYINA---IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1292
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
E D+R E + +K + R+ EE LA QR E E E+ A
Sbjct: 1293 EYVDLRTHYSELTTLTSQYIKFISETLRRMEE-EERLAEQQRAE-----ERERLAEVEAA 1346
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQ--KRELQQAVLHME 397
E+ R+ E A +A+ +A+ L Q + E + R + ++AQ KR +Q+ + +
Sbjct: 1347 L--EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1404
Query: 398 QRKQQQQQQQGHKAPAA 414
Q + + Q + +A AA
Sbjct: 1405 QSSEAEIQAKARQAEAA 1421
Score = 37.7 bits (86), Expect = 0.022
Identities = 87/413 (21%), Positives = 155/413 (37%), Gaps = 73/413 (17%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ---EVS 109
R+LQE + ++ +L A E + +L+ E + K+ + K Q E +
Sbjct: 2242 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2301
Query: 110 RLR-----MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA---RDLELL---- 157
RL+ + + ++ EQ +Q D + +Q Q T EA R LE+
Sbjct: 2302 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2361
Query: 158 -IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRY----------------LESLGEEQRK 200
++ ++++ A E+ +R+ E + LE ++
Sbjct: 2362 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2421
Query: 201 EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS--DG 258
+AER E RE K+ QLK EE+ + + +T + S D
Sbjct: 2422 DAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQTVQQEQLLQETQALQQSFLSEKDS 2479
Query: 259 VLD-----EQE---LEALFTKELEKVYDPKNEED-DMREMEEERLRMREHVMKNVDTNQD 309
+L EQE LE LF E+ K + E+ ++ME+ER R+
Sbjct: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL------------- 2526
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ ++EE R+ + EG +EEL++ E++ +E L + QRL
Sbjct: 2527 -VASMEE-----ARRRQHEAEEGVRR-------KQEELQQLEQQRRQQEELLAEENQRLR 2573
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKF 422
++ + L A E+ + + K + PAA E + F
Sbjct: 2574 EQLQLLEEQHRAALAHSEEVTAS--QVAATKTLPNGRDALDGPAAEAEPEHSF 2624
Score = 34.7 bits (78), Expect = 0.19
Identities = 74/331 (22%), Positives = 136/331 (41%), Gaps = 33/331 (9%)
Query: 107 EVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARD-LELLIQTATRDL 165
EV R R + ++ Q Q D ++ E L Q ++ E+ D L +Q A R
Sbjct: 1151 EVERWRERVAQLLERWQAVLAQTDVRQ--RELEQLGRQLRYYRESADPLGAWLQDARRRQ 1208
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
Q A + + E+ R ++L EE + E K+EE QR +++ + +
Sbjct: 1209 EQIQAMPLADSQAVR-----EQLRQEQALLEEIERHGE-KVEECQRFAKQYINA-IKDYE 1261
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE--------QELEALFTKELEKVY 277
QL +L+ + PK S+ V+ E EL L ++ ++ +
Sbjct: 1262 LQLVTYKAQLEPVASPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
Query: 278 DP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E++ R E++R RE + + V+ ++ L E A + + + E + +
Sbjct: 1317 ETLRRMEEEERLAEQQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375
Query: 337 EMHPAYTEE-------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+ EE + R +EEL A+ Q +++ EA RS+ R+E + R +
Sbjct: 1376 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
Query: 390 Q-QAVLHMEQRKQQQQQQQGHKAPAAHPEGQ 419
+ Q QR + + Q +A A E Q
Sbjct: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQ 1466
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 49/272 (18%)
Query: 189 RYLESLGEE-QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE-----------ELD 236
R + +GE Q++ ER +E ++ R R AQL E W+ EL+
Sbjct: 1132 RGAQEVGERLQQRHGERDVEVERWRERV----------AQLLERWQAVLAQTDVRQRELE 1181
Query: 237 GLDPN-RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE------- 288
L R+ ++ L D +++++A+ + + V + +E + E
Sbjct: 1182 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1241
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLE---EFLASTQRK---EFGDTGEGWETVEMHPAY 342
EE R + + + + +LVT + E +AS +K + G E V++ Y
Sbjct: 1242 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1301
Query: 343 TE-------------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+E E LRR EEE E + + +RL++ AL + + EA +
Sbjct: 1302 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1361
Query: 390 QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
QA ++ +Q+ Q++ + AA Q K
Sbjct: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1393
Score = 33.9 bits (76), Expect = 0.32
Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 55/366 (15%)
Query: 72 LQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAK-MDAEQDPNVQVD 130
L+ AE+ + +L+ + F + + + K RL L KA + E+ + D
Sbjct: 1834 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1893
Query: 131 HLNLLKQFEHLDPQNQHTFEAR-----DLELLIQTATRDLAQYDAAHHEEFKRYEMLK-E 184
L +Q E + +FE +LEL +L + + + + E + E
Sbjct: 1894 TLRQRRQVEEEILALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELE 1946
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
R+R L + E +R+EAE ++++ E + Q K EE++ L
Sbjct: 1947 AARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--------QRKAALEEVERLKAK--- 1995
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
V + + L +E + E R EE+ H
Sbjct: 1996 --------------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA----HAFAVQ 2037
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
Q+ TL+ Q + D G A EE R E AA+ +
Sbjct: 2038 QKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2091
Query: 365 AQRLSQ--ETEALGRSQGRLEAQK--RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
A+RL Q E +A R+Q + A+K +E +Q Q +Q +Q+ +A A E
Sbjct: 2092 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHK 2149
Query: 421 KFHPDT 426
KF T
Sbjct: 2150 KFAEQT 2155
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 71 KLQAANAEDIKSGKLSRELDFVSHHVRTKL-DELKRQEVSRLRMLLKAKMDAEQDPNVQ- 128
+LQA A ++ R+ + +R ++ DE +R+ + + + + K +AE Q
Sbjct: 1460 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1519
Query: 129 ----VDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDL---------------AQYD 169
++ L L + + AR +++ ++TA R AQ +
Sbjct: 1520 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1579
Query: 170 AAHHEEFKRYEMLKEH-ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQL 228
+ EE L+E ERR ++ E R+EAER+LE Q + E ++ + Q
Sbjct: 1580 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-----QA 1634
Query: 229 KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+EV ++ L ++ +E E EA + E+ + RE
Sbjct: 1635 EEVAQQKS--------------LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRE 1674
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR 348
+ E+ L + + + T Q RL +E + E G E EEEL
Sbjct: 1675 LAEQELEKQRQLAEG--TAQQRLAAEQELIRLRAETEQG---------EQQRQLLEEELA 1723
Query: 349 RFEEELAA---REAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
R + E AA + EL A+ ++ E E L S+ R E + R E+ KQ+ +
Sbjct: 1724 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEA 1777
Query: 406 QQGHKAPAAHPEGQLK 421
+ G A +L+
Sbjct: 1778 EAGRFRELAEEAARLR 1793
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/417 (19%), Positives = 171/417 (41%), Gaps = 79/417 (18%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ AE ++ + +++ VR +++EL + LKA+++AE +
Sbjct: 2193 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK---------LKARIEAENRALILR 2243
Query: 130 DHLNLLKQF-EHLDPQNQHTFEARDLELLIQTATR-------DLAQYDAAHHEEFK-RYE 180
D N + E + Q EA L + Q A R DLAQ A + K + +
Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2303
Query: 181 MLKEHERRRYLESLGEEQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLK-------E 230
++E R + L ++Q++ A+ R+L+E + + + G Q L+ E
Sbjct: 2304 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363
Query: 231 VWEELDGL----------------DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ E + L D RF + I ++ + ++++ + T E++
Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2423
Query: 275 KV---YDPKNEEDDMREMEEERLRMREHV-MKNVDTNQDRLVTLEEFLASTQRKEFGDTG 330
+ +D + + + E+E E+ ++++ + + + + + V E+ L TQ +
Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2483
Query: 331 EGWETVEMHPAYTEEELRRFE--------------EELAAREAELNAKAQRLSQETEALG 376
E +++ + E+E + E EE ++ ++ + QRL E
Sbjct: 2484 EK-DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQ----------------QQGHKAPAAHPE 417
R Q E R Q+ + +EQ+++QQ++ ++ H+A AH E
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2599
Score = 42.7 bits (99), Expect = 7e-04
Identities = 88/383 (22%), Positives = 149/383 (38%), Gaps = 63/383 (16%)
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EVSRLRMLLKAKMDAEQDPNVQVDHL 132
AE +L+ E + + T+ E +RQ E++RL+ A Q+ ++ +
Sbjct: 1687 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1746
Query: 133 N-----LLKQFEHLDPQNQHTFEARDLELLIQTAT-RDLAQYDA---AHHEEFKRYEMLK 183
LL + +++ T E L + R+LA+ A A EE KR L
Sbjct: 1747 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1806
Query: 184 EHERRRY-----------LESLGEEQR-----------KEAE----RKLEEQQRRHREHP 217
E + R L ++GE R KEAE R+L E + R
Sbjct: 1807 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1866
Query: 218 KVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ--ELEALFTK---- 271
+ +A ++E +L + + + + ++E+ L+A F K
Sbjct: 1867 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1926
Query: 272 ----ELEKVYDPKNEEDDMREMEEERL---RMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
ELE N ED +R E+ L R R+ + ++ +++ LA+ + +
Sbjct: 1927 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA-EEE 1985
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
E VE A EE R L R + +A+ +L+QE +Q RL+A
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARR-----LRERAEQESARQLQLAQEA-----AQKRLQA 2035
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
+++ AV EQ QQ QQ+
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQE 2058
Score = 38.9 bits (89), Expect = 0.010
Identities = 64/257 (24%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 187 RRRYLESLGEEQRKEAERK------LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
R+R LE LG + R E L++ +RR + + + SQA +++ +E L+
Sbjct: 1184 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Query: 241 -NRFNPKTF----FILHDINSDGVLDEQELEALFTK-ELEKVYDPKN------------- 281
R K F IN+ + + EL+ + K +LE V P
Sbjct: 1244 IERHGEKVEECQRFAKQYINA---IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1300
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
E D+R E + +K + R+ EE LA QR E E E+ A
Sbjct: 1301 EYVDLRTHYSELTTLTSQYIKFISETLRRMEE-EERLAEQQRAE-----ERERLAEVEAA 1354
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQ--KRELQQAVLHME 397
E+ R+ E A +A+ +A+ L Q + E + R + ++AQ KR +Q+ + +
Sbjct: 1355 L--EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1412
Query: 398 QRKQQQQQQQGHKAPAA 414
Q + + Q + +A AA
Sbjct: 1413 QSSEAEIQAKARQAEAA 1429
Score = 37.7 bits (86), Expect = 0.022
Identities = 87/413 (21%), Positives = 155/413 (37%), Gaps = 73/413 (17%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ---EVS 109
R+LQE + ++ +L A E + +L+ E + K+ + K Q E +
Sbjct: 2250 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2309
Query: 110 RLR-----MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA---RDLELL---- 157
RL+ + + ++ EQ +Q D + +Q Q T EA R LE+
Sbjct: 2310 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2369
Query: 158 -IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRY----------------LESLGEEQRK 200
++ ++++ A E+ +R+ E + LE ++
Sbjct: 2370 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2429
Query: 201 EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS--DG 258
+AER E RE K+ QLK EE+ + + +T + S D
Sbjct: 2430 DAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQTVQQEQLLQETQALQQSFLSEKDS 2487
Query: 259 VLD-----EQE---LEALFTKELEKVYDPKNEED-DMREMEEERLRMREHVMKNVDTNQD 309
+L EQE LE LF E+ K + E+ ++ME+ER R+
Sbjct: 2488 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL------------- 2534
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ ++EE R+ + EG +EEL++ E++ +E L + QRL
Sbjct: 2535 -VASMEE-----ARRRQHEAEEGVRR-------KQEELQQLEQQRRQQEELLAEENQRLR 2581
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKF 422
++ + L A E+ + + K + PAA E + F
Sbjct: 2582 EQLQLLEEQHRAALAHSEEVTAS--QVAATKTLPNGRDALDGPAAEAEPEHSF 2632
Score = 34.7 bits (78), Expect = 0.19
Identities = 74/331 (22%), Positives = 136/331 (41%), Gaps = 33/331 (9%)
Query: 107 EVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARD-LELLIQTATRDL 165
EV R R + ++ Q Q D ++ E L Q ++ E+ D L +Q A R
Sbjct: 1159 EVERWRERVAQLLERWQAVLAQTDVRQ--RELEQLGRQLRYYRESADPLGAWLQDARRRQ 1216
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
Q A + + E+ R ++L EE + E K+EE QR +++ + +
Sbjct: 1217 EQIQAMPLADSQAVR-----EQLRQEQALLEEIERHGE-KVEECQRFAKQYINA-IKDYE 1269
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE--------QELEALFTKELEKVY 277
QL +L+ + PK S+ V+ E EL L ++ ++ +
Sbjct: 1270 LQLVTYKAQLEPVASPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324
Query: 278 DP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E++ R E++R RE + + V+ ++ L E A + + + E + +
Sbjct: 1325 ETLRRMEEEERLAEQQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383
Query: 337 EMHPAYTEE-------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+ EE + R +EEL A+ Q +++ EA RS+ R+E + R +
Sbjct: 1384 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1443
Query: 390 Q-QAVLHMEQRKQQQQQQQGHKAPAAHPEGQ 419
+ Q QR + + Q +A A E Q
Sbjct: 1444 RLQLEATERQRGGAEGELQALRARAEEAEAQ 1474
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 49/272 (18%)
Query: 189 RYLESLGEE-QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE-----------ELD 236
R + +GE Q++ ER +E ++ R R AQL E W+ EL+
Sbjct: 1140 RGAQEVGERLQQRHGERDVEVERWRERV----------AQLLERWQAVLAQTDVRQRELE 1189
Query: 237 GLDPN-RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE------- 288
L R+ ++ L D +++++A+ + + V + +E + E
Sbjct: 1190 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1249
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLE---EFLASTQRK---EFGDTGEGWETVEMHPAY 342
EE R + + + + +LVT + E +AS +K + G E V++ Y
Sbjct: 1250 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1309
Query: 343 TE-------------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+E E LRR EEE E + + +RL++ AL + + EA +
Sbjct: 1310 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1369
Query: 390 QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
QA ++ +Q+ Q++ + AA Q K
Sbjct: 1370 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1401
Score = 33.9 bits (76), Expect = 0.32
Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 55/366 (15%)
Query: 72 LQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAK-MDAEQDPNVQVD 130
L+ AE+ + +L+ + F + + + K RL L KA + E+ + D
Sbjct: 1842 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1901
Query: 131 HLNLLKQFEHLDPQNQHTFEAR-----DLELLIQTATRDLAQYDAAHHEEFKRYEMLK-E 184
L +Q E + +FE +LEL +L + + + + E + E
Sbjct: 1902 TLRQRRQVEEEILALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELE 1954
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
R+R L + E +R+EAE ++++ E + Q K EE++ L
Sbjct: 1955 AARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--------QRKAALEEVERLKAK--- 2003
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
V + + L +E + E R EE+ H
Sbjct: 2004 --------------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA----HAFAVQ 2045
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
Q+ TL+ Q + D G A EE R E AA+ +
Sbjct: 2046 QKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2099
Query: 365 AQRLSQ--ETEALGRSQGRLEAQK--RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
A+RL Q E +A R+Q + A+K +E +Q Q +Q +Q+ +A A E
Sbjct: 2100 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHK 2157
Query: 421 KFHPDT 426
KF T
Sbjct: 2158 KFAEQT 2163
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 56.6 bits (135), Expect = 5e-08
Identities = 84/376 (22%), Positives = 148/376 (39%), Gaps = 67/376 (17%)
Query: 71 KLQAANAEDIKSGKLSRELDFVSHHVRTKL-DELKRQEVSRLRMLLKAKMDAEQDPNVQ- 128
+LQA A ++ R+ + +R ++ DE +R+ + + + + K +AE Q
Sbjct: 1501 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQR 1560
Query: 129 ----VDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDL---------------AQYD 169
++ L L + + AR +++ ++TA R AQ +
Sbjct: 1561 ALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1620
Query: 170 AAHHEEFKRYEMLKEH-ERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQL 228
+ EE L+E ERR ++ E R+EAER+LE Q + E ++ + Q
Sbjct: 1621 RSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRL-----QA 1675
Query: 229 KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+EV ++ L ++ +E E EA + E+ + RE
Sbjct: 1676 EEVAQQKS--------------LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRE 1715
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR 348
+ E+ L + + + T Q RL +E + E G E EEEL
Sbjct: 1716 LAEQELEKQRQLAEG--TAQQRLAAEQELIRLRAETEQG---------EQQRQLLEEELA 1764
Query: 349 RFEEELAA---REAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
R + E AA + EL A+ ++ E E L S+ R E + R E+ KQ+ +
Sbjct: 1765 RLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS------EKSKQRLEA 1818
Query: 406 QQGHKAPAAHPEGQLK 421
+ G A +L+
Sbjct: 1819 EAGRFRELAEEAARLR 1834
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/417 (19%), Positives = 171/417 (41%), Gaps = 79/417 (18%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV 129
E+LQ AE ++ + +++ VR +++EL + LKA+++AE +
Sbjct: 2234 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK---------LKARIEAENRALILR 2284
Query: 130 DHLNLLKQF-EHLDPQNQHTFEARDLELLIQTATR-------DLAQYDAAHHEEFK-RYE 180
D N + E + Q EA L + Q A R DLAQ A + K + +
Sbjct: 2285 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2344
Query: 181 MLKEHERRRYLESLGEEQRKEAE---RKLEEQQRRHREHPKVNVPGSQAQLK-------E 230
++E R + L ++Q++ A+ R+L+E + + + G Q L+ E
Sbjct: 2345 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2404
Query: 231 VWEELDGL----------------DPNRFNPKTFFILHDINSDGVLDEQELEALFTKELE 274
+ E + L D RF + I ++ + ++++ + T E++
Sbjct: 2405 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2464
Query: 275 KV---YDPKNEEDDMREMEEERLRMREHV-MKNVDTNQDRLVTLEEFLASTQRKEFGDTG 330
+ +D + + + E+E E+ ++++ + + + + + V E+ L TQ +
Sbjct: 2465 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2524
Query: 331 EGWETVEMHPAYTEEELRRFE--------------EELAAREAELNAKAQRLSQETEALG 376
E +++ + E+E + E EE ++ ++ + QRL E
Sbjct: 2525 EK-DSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQQ----------------QQGHKAPAAHPE 417
R Q E R Q+ + +EQ+++QQ++ ++ H+A AH E
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2640
Score = 42.7 bits (99), Expect = 7e-04
Identities = 88/383 (22%), Positives = 149/383 (38%), Gaps = 63/383 (16%)
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EVSRLRMLLKAKMDAEQDPNVQVDHL 132
AE +L+ E + + T+ E +RQ E++RL+ A Q+ ++ +
Sbjct: 1728 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKV 1787
Query: 133 N-----LLKQFEHLDPQNQHTFEARDLELLIQTAT-RDLAQYDA---AHHEEFKRYEMLK 183
LL + +++ T E L + R+LA+ A A EE KR L
Sbjct: 1788 RAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA 1847
Query: 184 EHERRRY-----------LESLGEEQR-----------KEAE----RKLEEQQRRHREHP 217
E + R L ++GE R KEAE R+L E + R
Sbjct: 1848 EEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL 1907
Query: 218 KVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ--ELEALFTK---- 271
+ +A ++E +L + + + + ++E+ L+A F K
Sbjct: 1908 EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1967
Query: 272 ----ELEKVYDPKNEEDDMREMEEERL---RMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
ELE N ED +R E+ L R R+ + ++ +++ LA+ + +
Sbjct: 1968 KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA-EEE 2026
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
E VE A EE R L R + +A+ +L+QE +Q RL+A
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARR-----LRERAEQESARQLQLAQEA-----AQKRLQA 2076
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
+++ AV EQ QQ QQ+
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQE 2099
Score = 38.9 bits (89), Expect = 0.010
Identities = 64/257 (24%), Positives = 108/257 (42%), Gaps = 40/257 (15%)
Query: 187 RRRYLESLGEEQRKEAERK------LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
R+R LE LG + R E L++ +RR + + + SQA +++ +E L+
Sbjct: 1225 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Query: 241 -NRFNPKTF----FILHDINSDGVLDEQELEALFTK-ELEKVYDPKN------------- 281
R K F IN+ + + EL+ + K +LE V P
Sbjct: 1285 IERHGEKVEECQRFAKQYINA---IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ 1341
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPA 341
E D+R E + +K + R+ EE LA QR E E E+ A
Sbjct: 1342 EYVDLRTHYSELTTLTSQYIKFISETLRRMEE-EERLAEQQRAE-----ERERLAEVEAA 1395
Query: 342 YTEEELRRFEEELAAREAELNAKAQRLSQ--ETEALGRSQGRLEAQ--KRELQQAVLHME 397
E+ R+ E A +A+ +A+ L Q + E + R + ++AQ KR +Q+ + +
Sbjct: 1396 L--EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLR 1453
Query: 398 QRKQQQQQQQGHKAPAA 414
Q + + Q + +A AA
Sbjct: 1454 QSSEAEIQAKARQAEAA 1470
Score = 37.7 bits (86), Expect = 0.022
Identities = 87/413 (21%), Positives = 155/413 (37%), Gaps = 73/413 (17%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ---EVS 109
R+LQE + ++ +L A E + +L+ E + K+ + K Q E +
Sbjct: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2350
Query: 110 RLR-----MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA---RDLELL---- 157
RL+ + + ++ EQ +Q D + +Q Q T EA R LE+
Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410
Query: 158 -IQTATRDLAQYDAAHHEEFKRYEMLKEHERRRY----------------LESLGEEQRK 200
++ ++++ A E+ +R+ E + LE ++
Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470
Query: 201 EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS--DG 258
+AER E RE K+ QLK EE+ + + +T + S D
Sbjct: 2471 DAERLREAIAELEREKEKLQQEAKLLQLKS--EEMQTVQQEQLLQETQALQQSFLSEKDS 2528
Query: 259 VLD-----EQE---LEALFTKELEKVYDPKNEED-DMREMEEERLRMREHVMKNVDTNQD 309
+L EQE LE LF E+ K + E+ ++ME+ER R+
Sbjct: 2529 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL------------- 2575
Query: 310 RLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
+ ++EE R+ + EG +EEL++ E++ +E L + QRL
Sbjct: 2576 -VASMEE-----ARRRQHEAEEGVRR-------KQEELQQLEQQRRQQEELLAEENQRLR 2622
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKF 422
++ + L A E+ + + K + PAA E + F
Sbjct: 2623 EQLQLLEEQHRAALAHSEEVTAS--QVAATKTLPNGRDALDGPAAEAEPEHSF 2673
Score = 34.7 bits (78), Expect = 0.19
Identities = 74/331 (22%), Positives = 136/331 (41%), Gaps = 33/331 (9%)
Query: 107 EVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARD-LELLIQTATRDL 165
EV R R + ++ Q Q D ++ E L Q ++ E+ D L +Q A R
Sbjct: 1200 EVERWRERVAQLLERWQAVLAQTDVRQ--RELEQLGRQLRYYRESADPLGAWLQDARRRQ 1257
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
Q A + + E+ R ++L EE + E K+EE QR +++ + +
Sbjct: 1258 EQIQAMPLADSQAVR-----EQLRQEQALLEEIERHGE-KVEECQRFAKQYINA-IKDYE 1310
Query: 226 AQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE--------QELEALFTKELEKVY 277
QL +L+ + PK S+ V+ E EL L ++ ++ +
Sbjct: 1311 LQLVTYKAQLEPVASPAKKPKV-----QSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1365
Query: 278 DP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E++ R E++R RE + + V+ ++ L E A + + + E + +
Sbjct: 1366 ETLRRMEEEERLAEQQRAEERERLAE-VEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 337 EMHPAYTEE-------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+ EE + R +EEL A+ Q +++ EA RS+ R+E + R +
Sbjct: 1425 QEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1484
Query: 390 Q-QAVLHMEQRKQQQQQQQGHKAPAAHPEGQ 419
+ Q QR + + Q +A A E Q
Sbjct: 1485 RLQLEATERQRGGAEGELQALRARAEEAEAQ 1515
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/272 (22%), Positives = 111/272 (40%), Gaps = 49/272 (18%)
Query: 189 RYLESLGEE-QRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE-----------ELD 236
R + +GE Q++ ER +E ++ R R AQL E W+ EL+
Sbjct: 1181 RGAQEVGERLQQRHGERDVEVERWRERV----------AQLLERWQAVLAQTDVRQRELE 1230
Query: 237 GLDPN-RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMRE------- 288
L R+ ++ L D +++++A+ + + V + +E + E
Sbjct: 1231 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGE 1290
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLE---EFLASTQRK---EFGDTGEGWETVEMHPAY 342
EE R + + + + +LVT + E +AS +K + G E V++ Y
Sbjct: 1291 KVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHY 1350
Query: 343 TE-------------EELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKREL 389
+E E LRR EEE E + + +RL++ AL + + EA +
Sbjct: 1351 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAK 1410
Query: 390 QQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLK 421
QA ++ +Q+ Q++ + AA Q K
Sbjct: 1411 AQAEREAKELQQRMQEEVVRREEAAVDAQQQK 1442
Score = 33.9 bits (76), Expect = 0.32
Identities = 80/366 (21%), Positives = 134/366 (36%), Gaps = 55/366 (15%)
Query: 72 LQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAK-MDAEQDPNVQVD 130
L+ AE+ + +L+ + F + + + K RL L KA + E+ + D
Sbjct: 1883 LKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVED 1942
Query: 131 HLNLLKQFEHLDPQNQHTFEAR-----DLELLIQTATRDLAQYDAAHHEEFKRYEMLK-E 184
L +Q E + +FE +LEL +L + + + + E + E
Sbjct: 1943 TLRQRRQVEEEILALKASFEKAAAGKAELEL-------ELGRIRSNAEDTLRSKEQAELE 1995
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
R+R L + E +R+EAE ++++ E + Q K EE++ L
Sbjct: 1996 AARQRQLAAEEERRRREAEERVQKSLAAEEEAAR--------QRKAALEEVERLKAK--- 2044
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
V + + L +E + E R EE+ H
Sbjct: 2045 --------------VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA----HAFAVQ 2086
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
Q+ TL+ Q + D G A EE R E AA+ +
Sbjct: 2087 QKEQELQQTLQ------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2140
Query: 365 AQRLSQ--ETEALGRSQGRLEAQK--RELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQL 420
A+RL Q E +A R+Q + A+K +E +Q Q +Q +Q+ +A A E
Sbjct: 2141 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEMEKHK 2198
Query: 421 KFHPDT 426
KF T
Sbjct: 2199 KFAEQT 2204
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 55.8 bits (133), Expect = 8e-08
Identities = 62/343 (18%), Positives = 159/343 (46%), Gaps = 48/343 (13%)
Query: 96 VRTKLDELKRQEV----SRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA 151
+R + ++++RQE +M + +M E++ ++ + ++ E + Q + +E
Sbjct: 330 IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 389
Query: 152 RDLELLIQTATRDLAQYDAAHHEEFKRYE--MLKEHERRRYLESL----------GEEQR 199
+ I+ + + + +E KR E ++E E+R+ E+ EE+
Sbjct: 390 EEK---IRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKI 446
Query: 200 KEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGV 259
+E E+K+ Q+ + E K+ + + +E+W + + + + +H+ +
Sbjct: 447 REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHE--QEEK 504
Query: 260 LDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDT--NQDRLVTLEEF 317
+ +QE E ++ +E EK+ + +E+ +RE EE+ R E + + + ++++ E+
Sbjct: 505 IRKQE-EKVWRQE-EKI---REQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKI 559
Query: 318 LASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGR 377
+R+E D + W EE++R EE++ +E ++ + ++ ++ E + +
Sbjct: 560 WEEEKRQEQED--KMWRQ--------EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK 609
Query: 378 SQGRLEAQK----------RELQQAVLHMEQRKQQQQQQQGHK 410
+ ++ Q+ RE ++ + E+ Q+Q+++ G +
Sbjct: 610 QEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQ 652
Score = 51.2 bits (121), Expect = 2e-06
Identities = 58/323 (17%), Positives = 142/323 (43%), Gaps = 45/323 (13%)
Query: 99 KLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLI 158
K+ E ++++ +M + + EQ+ ++ + +Q E + Q + E +
Sbjct: 418 KIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR----- 472
Query: 159 QTATRDLAQYDAAHHEE--FKRYEMLKEHER--RRYLESLG--EEQRKEAERKLEEQQRR 212
Q Q + H +E +++ E + E E R+ E + EE+ +E E K+ EQ+ +
Sbjct: 473 QEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK 532
Query: 213 H-REHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDE---QELEAL 268
R+ K+ + +E+W E + + + + +E QE E
Sbjct: 533 MWRQEEKIR------EQEEMWREEEKMH---------------EQEKIWEEEKRQEQEDK 571
Query: 269 FTKELEKVYDPKN----EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRK 324
++ EK+ + + +E+ +RE EE+R E + K Q+ + +E Q +
Sbjct: 572 MWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK-----QEEKIREQEEKIQEQEE 626
Query: 325 EFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEA 384
+ + E E EE++ EE++ +E ++ + + + ++ E + + ++
Sbjct: 627 KIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIRE 686
Query: 385 QKRELQQAVLHMEQRKQQQQQQQ 407
Q+ ++++ M++++++ +Q+
Sbjct: 687 QEEKIREQEEMMQEQEEKMWEQE 709
Score = 50.4 bits (119), Expect = 3e-06
Identities = 59/326 (18%), Positives = 148/326 (45%), Gaps = 43/326 (13%)
Query: 87 RELDFVSHHV-RTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQN 145
REL+ H + + E KRQE ++R EQ+ Q + +Q E +
Sbjct: 394 RELEEKMHEQEKIREQEEKRQEEEKIR---------EQEKR-QEQEAKMWRQEEKI---- 439
Query: 146 QHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRK--EAE 203
R+ E I+ + + + + HE+ E ++E E+R+ E + ++ K E E
Sbjct: 440 ------REQEEKIREQEKKMWRQEEKIHEQ----EKIREEEKRQEQEEMWRQEEKIHEQE 489
Query: 204 RKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQ 263
++++ H + K+ + Q ++VW + + + + + + +++
Sbjct: 490 EIWRQKEKMHEQEEKI-----RKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQE 544
Query: 264 ELEALFTKELEKVYDPKN--EEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLAST 321
E+ +E EK+++ + EE+ +E E++ R E + + ++++ EE +
Sbjct: 545 EM----WREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQ----EEKVWRQEEKIREQ 596
Query: 322 QRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGR 381
+ K + W+ E EE+++ EE++ +E ++ + + ++ E +G + +
Sbjct: 597 EEKRQEQEEKMWKQEEKIREQ-EEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK 655
Query: 382 LEAQKRELQQAVLHMEQRKQQQQQQQ 407
+ Q+ ++Q+ M +++++ ++Q+
Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQE 681
Score = 47.4 bits (111), Expect = 3e-05
Identities = 57/284 (20%), Positives = 122/284 (42%), Gaps = 37/284 (13%)
Query: 116 KAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEE 175
K KM EQ+ ++ + +Q E + Q + + R+ E + + + + EE
Sbjct: 495 KEKMH-EQEEKIRKQEEKVWRQEEKIREQEE---KIREQEEKMWRQEEKIREQEEMWREE 550
Query: 176 FKRYEMLK--EHERRRYLESL---GEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKE 230
K +E K E E+R+ E EE+ +E E K+ Q+ + RE + Q Q ++
Sbjct: 551 EKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKR----QEQEEK 606
Query: 231 VWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREME 290
+W++ + + QE E ++ EK+ E+++M + +
Sbjct: 607 MWKQEEKIREQEEKI-----------------QEQEEKIREQEEKI----REQEEMTQEQ 645
Query: 291 EERLRMREHVMKNVDTN---QDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEEL 347
EE++ +E M + Q+ + +E Q K+ + E E EE++
Sbjct: 646 EEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 705
Query: 348 RRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQ 391
EE++ +E ++ + +++ ++ E + + RL Q+ ++Q+
Sbjct: 706 WEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 44.7 bits (104), Expect = 2e-04
Identities = 78/378 (20%), Positives = 157/378 (41%), Gaps = 53/378 (14%)
Query: 91 FVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPN-VQVDHLNLLKQFEHLDPQNQHTF 149
+ S H +L+ R +SRL K + EQ + V + E L +
Sbjct: 147 YYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEELTKER---- 202
Query: 150 EARDLELLIQTAT-RDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKL-- 206
+A LEL T T +L + +A E+ + L E E+ ++ E +RK KL
Sbjct: 203 DALSLELYRNTITDEELKEKNAKLQEKLQ----LVESEKSEIQLNVKELKRKLERAKLLL 258
Query: 207 -EEQQRRHREHPKVNVPGSQAQLK------EVWEELDGLDPNRFNPKTFFILHDINSDGV 259
++Q + +H + A+L+ E+W L N+ + + + +
Sbjct: 259 PQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRL-----NQQQEEKMWRQEEKIQEWE 313
Query: 260 LDEQELEALFTKELEKVYDPKNEEDDMREMEE------ERLRMREHVMKNVDTNQDRLVT 313
QE E ++ EK+ + +E+ MR EE E++R +E +M ++++
Sbjct: 314 EKIQEQEEKIREQEEKI---REQEEKMRRQEEMMWEKEEKMRRQEEMMWE---KEEKMRR 367
Query: 314 LEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETE 373
EE + + K WE EE++R EE++ +E ++ ++ E
Sbjct: 368 QEEMMWEKEEKMRRQEEMMWEK--------EEKIRELEEKMHEQE--------KIREQEE 411
Query: 374 ALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHPDTDDVPVPA 433
+ E +KR+ Q+A + ++ K ++Q+++ + + K H + + +
Sbjct: 412 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH-EQEKIREEE 470
Query: 434 PAGDQKEVDTSEKKLLER 451
+Q+E+ E+K+ E+
Sbjct: 471 KRQEQEEMWRQEEKIHEQ 488
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 55.5 bits (132), Expect = 1e-07
Identities = 64/271 (23%), Positives = 113/271 (41%), Gaps = 33/271 (12%)
Query: 174 EEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE 233
E+ +R ++ ++ RR L E+R + E+ + +E K + AQ+ E E
Sbjct: 552 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 611
Query: 234 ELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMR-----E 288
+ + + +E+ + K++E+V + +E++ R +
Sbjct: 612 K-------------------AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 652
Query: 289 MEEERLRMREHVMKNVDTNQDRL-VTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEEL 347
EEE R +E + K + Q+RL E + QR++ E E E+E
Sbjct: 653 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
Query: 348 RRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQ---- 403
R E +LA E E + +RL E E R + L QK +LQ+ + +++++QQ
Sbjct: 713 REQERQLA--EQERRREQERLQAERELQEREKA-LRLQKEQLQRELEEKKKKEEQQRLAE 769
Query: 404 -QQQQGHKAPAAHPEGQLKFHPDTDDVPVPA 433
Q Q+ + A G K T DV PA
Sbjct: 770 RQLQEEQEKKAKEAAGASKALNVTVDVQSPA 800
Score = 43.9 bits (102), Expect = 3e-04
Identities = 54/226 (23%), Positives = 98/226 (43%), Gaps = 32/226 (14%)
Query: 184 EHERRRYLESLGEEQRKEAER--KLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPN 241
E ER+R LE+L ++ E R K+EE +RR E K+ + +L++V + + ++
Sbjct: 536 EKERQR-LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK---REERLRKVLQARERVEQM 591
Query: 242 RFNPKTFFILHDINSDGVLDEQELEALFT-KELEKVYDPKNEEDDMREMEEERLRMREHV 300
+ K D ++ + E L K +K K EE + R +EE R +
Sbjct: 592 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
Query: 301 MKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAE 360
+ + + +E L + +E +E LR+ E A R AE
Sbjct: 652 QQEEEERRH-----QELLQKKKEEE------------------QERLRKAAE--AKRLAE 686
Query: 361 LNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQ 406
+ +R + E R Q R E ++RE ++ + E+R++Q++ Q
Sbjct: 687 QREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
Score = 43.9 bits (102), Expect = 3e-04
Identities = 71/323 (21%), Positives = 120/323 (37%), Gaps = 95/323 (29%)
Query: 92 VSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA 151
V R +L+E+K + RLR +L+A+ EQ + + ++F +D + + E
Sbjct: 559 VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE--QKFAQIDEKTEKAKEE 616
Query: 152 RDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQR 211
R LA+ A K+ E E E RR E EE R+ + EE++R
Sbjct: 617 R------------LAEEKAKKKAAAKKME---EVEARRKQE---EEARRLRWLQQEEEER 658
Query: 212 RHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTK 271
RH+E + Q +L++ E K
Sbjct: 659 RHQELLQKKKEEEQERLRKAAE------------------------------------AK 682
Query: 272 ELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGE 331
L + + + E + RE E RE + E LA +R+
Sbjct: 683 RLAEQREQERREQERREQERREQERREQERRE----------QERQLAEQERRR------ 726
Query: 332 GWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQ 391
E+E + E EL RE L + ++L +E E E +K+E QQ
Sbjct: 727 ------------EQERLQAERELQEREKALRLQKEQLQRELE---------EKKKKEEQQ 765
Query: 392 AVLHMEQRKQQQQQQQGHKAPAA 414
+ E++ Q++Q+++ +A A
Sbjct: 766 RL--AERQLQEEQEKKAKEAAGA 786
Score = 42.0 bits (97), Expect = 0.001
Identities = 51/208 (24%), Positives = 87/208 (41%), Gaps = 56/208 (26%)
Query: 240 PNRFNPKTFFILHDINSDGVLDEQELEALFTKE-LEKVYDPKNEEDDMREMEEERLRMRE 298
P R +PK F+ + Q LE L KE E++ K EED R +EE +L+ RE
Sbjct: 525 PLRMDPKCSFVEKE--------RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK-RE 575
Query: 299 HVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVE--------------------- 337
++ V ++R+ ++E ++F E E +
Sbjct: 576 ERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 635
Query: 338 ------------MHPAYTEEELRRFEEELAAREAELN------AKAQRLSQETEALGRSQ 379
+ EEE RR +E L ++ E A+A+RL+++ E R Q
Sbjct: 636 EARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQ 695
Query: 380 GRLEAQKRELQQAVLHMEQRKQQQQQQQ 407
R E ++RE E+R+Q++++Q+
Sbjct: 696 ERREQERRE-------QERREQERREQE 716
Score = 40.0 bits (92), Expect = 0.004
Identities = 38/168 (22%), Positives = 77/168 (45%), Gaps = 9/168 (5%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLR 112
R L+EV L+ + R+ LQA + + ++++ + K ++ K + ++ +
Sbjct: 565 RRLEEV--KLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 622
Query: 113 MLLKA---KMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYD 169
KA KM+ + Q + L+ + + + +H + + Q R A+
Sbjct: 623 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK 682
Query: 170 --AAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHRE 215
A E+ +R + +E ERR + E++R+E ER+L EQ+RR +
Sbjct: 683 RLAEQREQERREQERREQERRE--QERREQERREQERQLAEQERRREQ 728
Score = 35.8 bits (81), Expect = 0.084
Identities = 36/177 (20%), Positives = 70/177 (39%), Gaps = 18/177 (10%)
Query: 100 LDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQ 159
L + K +E RLR +AK AEQ + + ++ + Q + E R+ E +
Sbjct: 664 LQKKKEEEQERLRKAAEAKRLAEQR---EQERREQERREQERREQERREQERREQERQLA 720
Query: 160 TATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKV 219
R Q E + E ++ + L E+++KE +++L E+Q + + K
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 780
Query: 220 NVPGSQAQLKEVWEELDG-------------LDPNRFNPKTFFILHDINSDGVLDEQ 263
++ V ++ P + NP + + D+NSD D++
Sbjct: 781 KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGM--DLNSDDSTDDE 835
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 55.5 bits (132), Expect = 1e-07
Identities = 64/271 (23%), Positives = 113/271 (41%), Gaps = 33/271 (12%)
Query: 174 EEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWE 233
E+ +R ++ ++ RR L E+R + E+ + +E K + AQ+ E E
Sbjct: 548 EQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTE 607
Query: 234 ELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMR-----E 288
+ + + +E+ + K++E+V + +E++ R +
Sbjct: 608 K-------------------AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQ 648
Query: 289 MEEERLRMREHVMKNVDTNQDRL-VTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEEL 347
EEE R +E + K + Q+RL E + QR++ E E E+E
Sbjct: 649 QEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708
Query: 348 RRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQ---- 403
R E +LA E E + +RL E E R + L QK +LQ+ + +++++QQ
Sbjct: 709 REQERQLA--EQERRREQERLQAERELQEREKA-LRLQKEQLQRELEEKKKKEEQQRLAE 765
Query: 404 -QQQQGHKAPAAHPEGQLKFHPDTDDVPVPA 433
Q Q+ + A G K T DV PA
Sbjct: 766 RQLQEEQEKKAKEAAGASKALNVTVDVQSPA 796
Score = 45.8 bits (107), Expect = 8e-05
Identities = 55/227 (24%), Positives = 99/227 (43%), Gaps = 32/227 (14%)
Query: 183 KEHERRRYLESLGEEQRKEAER--KLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDP 240
KE ER+R LE+L ++ E R K+EE +RR E K+ + +L++V + + ++
Sbjct: 531 KEKERQR-LENLRRKEEAEQLRRQKVEEDKRRRLEEVKLK---REERLRKVLQARERVEQ 586
Query: 241 NRFNPKTFFILHDINSDGVLDEQELEALFT-KELEKVYDPKNEEDDMREMEEERLRMREH 299
+ K D ++ + E L K +K K EE + R +EE R
Sbjct: 587 MKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRW 646
Query: 300 VMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREA 359
+ + + + +E L + +E +E LR+ E A R A
Sbjct: 647 LQQEEEERRH-----QELLQKKKEEE------------------QERLRKAAE--AKRLA 681
Query: 360 ELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQ 406
E + +R + E R Q R E ++RE ++ + E+R++Q++ Q
Sbjct: 682 EQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 728
Score = 43.9 bits (102), Expect = 3e-04
Identities = 71/323 (21%), Positives = 120/323 (37%), Gaps = 95/323 (29%)
Query: 92 VSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEA 151
V R +L+E+K + RLR +L+A+ EQ + + ++F +D + + E
Sbjct: 555 VEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIE--QKFAQIDEKTEKAKEE 612
Query: 152 RDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQR 211
R LA+ A K+ E E E RR E EE R+ + EE++R
Sbjct: 613 R------------LAEEKAKKKAAAKKME---EVEARRKQE---EEARRLRWLQQEEEER 654
Query: 212 RHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTK 271
RH+E + Q +L++ E K
Sbjct: 655 RHQELLQKKKEEEQERLRKAAE------------------------------------AK 678
Query: 272 ELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGE 331
L + + + E + RE E RE + E LA +R+
Sbjct: 679 RLAEQREQERREQERREQERREQERREQERRE----------QERQLAEQERRR------ 722
Query: 332 GWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQ 391
E+E + E EL RE L + ++L +E E E +K+E QQ
Sbjct: 723 ------------EQERLQAERELQEREKALRLQKEQLQRELE---------EKKKKEEQQ 761
Query: 392 AVLHMEQRKQQQQQQQGHKAPAA 414
+ E++ Q++Q+++ +A A
Sbjct: 762 RL--AERQLQEEQEKKAKEAAGA 782
Score = 38.1 bits (87), Expect = 0.017
Identities = 39/173 (22%), Positives = 77/173 (44%), Gaps = 19/173 (10%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLR 112
R L+EV L+ + R+ LQA + + ++++ + K ++ K + ++ +
Sbjct: 561 RRLEEV--KLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEK 618
Query: 113 MLLKA------KMDAEQDPNVQVDHLNLLKQFE----HLDPQNQHTFEARDLELLIQTAT 162
KA +++A + + L L+Q E H + + E ++ A
Sbjct: 619 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK 678
Query: 163 RDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHRE 215
R Q + E+ +R + +E ERR E++R+E ER+L EQ+RR +
Sbjct: 679 RLAEQREQERREQERREQERREQERR-------EQERREQERQLAEQERRREQ 724
Score = 35.8 bits (81), Expect = 0.084
Identities = 36/177 (20%), Positives = 70/177 (39%), Gaps = 18/177 (10%)
Query: 100 LDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQ 159
L + K +E RLR +AK AEQ + + ++ + Q + E R+ E +
Sbjct: 660 LQKKKEEEQERLRKAAEAKRLAEQR---EQERREQERREQERREQERREQERREQERQLA 716
Query: 160 TATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKV 219
R Q E + E ++ + L E+++KE +++L E+Q + + K
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKA 776
Query: 220 NVPGSQAQLKEVWEELDG-------------LDPNRFNPKTFFILHDINSDGVLDEQ 263
++ V ++ P + NP + + D+NSD D++
Sbjct: 777 KEAAGASKALNVTVDVQSPACTSYQMTPQGHRAPPKINPDNYGM--DLNSDDSTDDE 831
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 55.1 bits (131), Expect = 1e-07
Identities = 78/373 (20%), Positives = 157/373 (42%), Gaps = 59/373 (15%)
Query: 69 REKLQAANAEDIKSG-KLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNV 127
+E+L+A + I++ +LS+EL++++ V+ ++LK ++ + LK D +V
Sbjct: 117 KEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSV 176
Query: 128 QVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHER 187
+ L ++ E L QN L ++T T +L A E+ LK
Sbjct: 177 KYREKRLEQEKELLHSQNTW------LNTELKTKTDELL---ALGREKGNEILELK---- 223
Query: 188 RRYLESLGEEQRKEAERKLEEQQ---RRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
E +KE +LEEQ + EH + +V +LKE E+ ++ N
Sbjct: 224 ------CNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHN 277
Query: 245 PKTFFI-LHDINSDGVLDEQELEALFTKELEKVYDPKNE--------EDDMREMEEERLR 295
I L ++ D + T+ +E+++ E +D + E+E+ + +
Sbjct: 278 ELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQ 337
Query: 296 MREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGE------------------GWETVE 337
M + +++ + + L + L++T+RK + E G + E
Sbjct: 338 MEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTE 397
Query: 338 MHPAYTEE---------ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRE 388
++ AY E E +R + L E+ AKA L ++ E R+Q + + +
Sbjct: 398 LYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVK 457
Query: 389 LQQAVLHMEQRKQ 401
L+QA+ +++ ++
Sbjct: 458 LEQAMKEIQRLQE 470
Score = 38.9 bits (89), Expect = 0.010
Identities = 59/276 (21%), Positives = 110/276 (39%), Gaps = 40/276 (14%)
Query: 146 QHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERK 205
Q E +L L ++ L ++ A E + LK + +ES E+Q E E++
Sbjct: 6 QQVLERTELNKLPKSVQNKLEKFLADQQSEI---DGLKGRHEKFKVES--EQQYFEIEKR 60
Query: 206 LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHD----INSDGVLD 261
L Q R + + +L+++ +L L K I D I S
Sbjct: 61 LSHSQERLVNETR-ECQSLRLELEKLNNQLKALTEKN---KELEIAQDRNIAIQSQFTRT 116
Query: 262 EQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLAST 321
++ELEA ++ + + + ++ + E+ R+ E + ++ T + + L+E AS
Sbjct: 117 KEELEA---EKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQAS- 172
Query: 322 QRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQG- 380
++ Y E+ L + +E L ++ LN + + + E ALGR +G
Sbjct: 173 ---------------DVSVKYREKRLEQEKELLHSQNTWLNTELKTKTDELLALGREKGN 217
Query: 381 -------RLEAQKRELQQAVLHMEQRKQQQQQQQGH 409
LE +K E+ + M K + Q H
Sbjct: 218 EILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKH 253
Score = 37.4 bits (85), Expect = 0.029
Identities = 79/373 (21%), Positives = 158/373 (42%), Gaps = 57/373 (15%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLR 112
R LQE+ D L + REK+Q + +L ++ + ++ + T +++ R+E RL
Sbjct: 1233 RELQELQDSLNAE---REKVQVTAKTMAQHEELMKKTETMNVVMET--NKMLREEKERLE 1287
Query: 113 MLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAH 172
L+ + V+ L++L P + E + ++Q + L
Sbjct: 1288 QDLQ-----QMQAKVRKLELDIL-------PLQEANAELSEKSGMLQAEKKLL------- 1328
Query: 173 HEEFKRYEMLKEHERRRYLESLGEEQRK-----EAERKLEEQQRRHREHPKVNVPGSQAQ 227
E+ KR++ +H + + EE RK E K +Q K + S A
Sbjct: 1329 EEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNAS 1388
Query: 228 LKEVWEELDGL--DPNRFNPKTFFILHDINSDGVLDEQELEALFT--KELEKVYDPKNEE 283
L + L D N+ + I D+++ ++D QE T K++ + Y + EE
Sbjct: 1389 LTNNQNLIQSLKEDLNKVRTEKETIQKDLDAK-IIDIQEKVKTITQVKKIGRRYKTQYEE 1447
Query: 284 DDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYT 343
++ ++ ++ E ++ +Q++ V+++E +E +T ET
Sbjct: 1448 -----LKAQQDKVMETSAQSSGDHQEQHVSVQEM------QELKETLNQAETKSKS---L 1493
Query: 344 EEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQ- 402
E ++ ++ L+ +E E A+ L ++T L Q L +++LQ EQ +QQ
Sbjct: 1494 ESQVENLQKTLSEKETE----ARNLQEQTVQL---QSELSRLRQDLQDRTTQEEQLRQQI 1546
Query: 403 -QQQQQGHKAPAA 414
+++++ KA A
Sbjct: 1547 TEKEEKTRKAIVA 1559
Score = 36.2 bits (82), Expect = 0.064
Identities = 90/455 (19%), Positives = 177/455 (38%), Gaps = 84/455 (18%)
Query: 24 VLAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSG 83
+L+ +GA EE A SP T + ++ + + E + E E +++
Sbjct: 359 LLSATKRKGAILSEEELAAMSP-TAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENK 417
Query: 84 KLSRELDFVSHHVRTKLDELKRQE---------VSRLRMLLKAKMDAEQDPNVQVDHLNL 134
++++ LD + V K LKRQ V+ L + L+ M Q D N
Sbjct: 418 RINKYLDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKAN- 476
Query: 135 LKQFEHLDPQNQHT-FEARDLELLIQTATRDL----------------------AQYDAA 171
KQ L+ N+ + +DL I+ +L ++ +
Sbjct: 477 -KQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEEVSSADISSSSEVISQ 535
Query: 172 HHEEFKRYEMLKEHERRRY--LESLGEEQRKEAER-----------KLE------EQQRR 212
H ++ E L++ +R L LGE + +E + KLE EQ R+
Sbjct: 536 HLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSSKITELQLKLESALTELEQLRK 595
Query: 213 HREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDG-------------- 258
R+H ++ + S + ++++ L P L D++
Sbjct: 596 SRQH-QMQLVDSIVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPKRPSTSQTVSTP 654
Query: 259 ----VLDEQE-LEALFT-KELEKVYDP-KNEEDDMREMEEERLRMREHVMKNVDTNQDRL 311
V++ E +EA K+L+++++ K E+ + +++ E+L + + ++ + ++
Sbjct: 655 APVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKIQNEQLEKLQEQVTDLRSQNTKI 714
Query: 312 VTLEEFLASTQRKEFGDTGEGW--ETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLS 369
T +F AS + + D EG+ E +H E ++ +E +N Q L
Sbjct: 715 STQLDF-ASKRYEMLQDNVEGYRREITSLH-----ERNQKLTATTQKQEQIINTMTQDLR 768
Query: 370 QETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQ 404
E L ++ R E K+E + L + QQ++
Sbjct: 769 GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRE 803
Score = 34.3 bits (77), Expect = 0.24
Identities = 75/400 (18%), Positives = 153/400 (38%), Gaps = 67/400 (16%)
Query: 60 DVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVR---TKLDELKRQEVSRLRMLLK 116
++LE + K + + + + L + + HV TKL E K Q+ S ++
Sbjct: 218 EILELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQAS-----ME 272
Query: 117 AKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEF 176
K E + ++++ +L + N+ T +L L++ A + + A +
Sbjct: 273 EKFHNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEA----GEANKAIQDHL 328
Query: 177 KRYEMLKEHERRRYLESLGE--------------EQRKEA---ERKLEEQQRRHREHPKV 219
E K+ + LE +G +RK A E +L K+
Sbjct: 329 LEVEQSKDQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKI 388
Query: 220 NVPGSQ-AQLKEVWEE------LDGLDPNRFNPKTFFILHDINSDGVLDEQELEAL---- 268
PG + +L + E L+ L+ R N I+ ++ + + +++ E
Sbjct: 389 VKPGMKLTELYNAYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQ 448
Query: 269 ------------FTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLE- 315
KE++++ + ++ + + E R E +K++ + Q R++ +E
Sbjct: 449 KAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDL-SQQIRVLLMEL 507
Query: 316 -----EFLASTQRKEFGDTGEGWETVEMH-PAYTE-EELRRFEEELAAREAELNAKAQRL 368
+ + D E + H +Y EEL++ + L EL +R
Sbjct: 508 EEARGNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETRERE 567
Query: 369 SQETEALGRSQGRLEAQKRELQQAVLHMEQ-RKQQQQQQQ 407
QET + ++ + +L+ A+ +EQ RK +Q Q Q
Sbjct: 568 EQET-----TSSKITELQLKLESALTELEQLRKSRQHQMQ 602
Score = 33.9 bits (76), Expect = 0.32
Identities = 86/398 (21%), Positives = 160/398 (40%), Gaps = 30/398 (7%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLL-KAKMDAEQDPNVQ 128
E LQAA + K + + L+ + ++L E K R RML + + +++
Sbjct: 1094 EALQAAKEQVSKMASVRQHLEETTQKAESQLLECKASWEERERMLKDEVSKCVCRCEDLE 1153
Query: 129 VDHLNLLKQFEHL-DPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHER 187
+ L Q E L D E L + + +Q F R E KE
Sbjct: 1154 KQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQEQILEILRFIRRE--KEIAE 1211
Query: 188 RRY----LESLGEEQRKEA-ERKLEE-QQRRHREHPKVNVPG-SQAQLKEVWEELDGLDP 240
R+ +ESL QR E ER+L+E Q + E KV V + AQ +E+ ++ + ++
Sbjct: 1212 TRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNV 1271
Query: 241 NRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHV 300
K + + EQ+L+ + K + D ++ E+ E+ M +
Sbjct: 1272 VMETNKM------LREEKERLEQDLQQMQAKVRKLELDILPLQEANAELSEKS-GMLQAE 1324
Query: 301 MKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTE------EELRRFEEEL 354
K ++ + R + L S Q+ DT E + + +T+ EE+ R + E+
Sbjct: 1325 KKLLEEDVKRWKARNQHLVSQQKDP--DTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEI 1382
Query: 355 AAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQ--QQQQQQGHKAP 412
A A L + E L + + E +++L ++ ++++ + Q ++ G +
Sbjct: 1383 ARSNASLTNNQNLIQSLKEDLNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYK 1442
Query: 413 AAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLE 450
+ E LK D +GD +E S +++ E
Sbjct: 1443 TQYEE--LKAQQDKVMETSAQSSGDHQEQHVSVQEMQE 1478
Score = 29.6 bits (65), Expect = 6.0
Identities = 64/373 (17%), Positives = 152/373 (40%), Gaps = 63/373 (16%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGK----LSRELDFVSHHVRTKLDELKRQEV 108
R+++ ++ ET + + A E ++ + L REL + + + +++ Q
Sbjct: 1201 RFIRREKEIAET------RFEVAQVESLRYRQRVELLERELQELQDSLNAEREKV--QVT 1252
Query: 109 SRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEAR----DLELL-IQTATR 163
++ + M + NV ++ +L++ + Q+ +A+ +L++L +Q A
Sbjct: 1253 AKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQDLQQMQAKVRKLELDILPLQEANA 1312
Query: 164 DLAQYDAAHHEEFKRYE--MLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNV 221
+L++ E K E + + R ++L S ++ E RKL ++ H +
Sbjct: 1313 ELSEKSGMLQAEKKLLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTK------ 1366
Query: 222 PGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKN 281
+++++ EE+ L ++ + + Q L ++L KV K
Sbjct: 1367 -----RIQQLTEEIGRLKAEIAR----------SNASLTNNQNLIQSLKEDLNKVRTEK- 1410
Query: 282 EEDDMREMEEERLRMREHVM---------KNVDTNQDRLVTLEEFLASTQRKEFGDTGEG 332
E ++++ + + ++E V + T + L ++ + T + GD E
Sbjct: 1411 -ETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMETSAQSSGDHQEQ 1469
Query: 333 WETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQA 392
+V+ E++ +E L E K++ L + E L ++ E + R LQ+
Sbjct: 1470 HVSVQ--------EMQELKETLNQAET----KSKSLESQVENLQKTLSEKETEARNLQEQ 1517
Query: 393 VLHMEQRKQQQQQ 405
+ ++ + +Q
Sbjct: 1518 TVQLQSELSRLRQ 1530
>gi|34878777 ring finger protein 20 [Homo sapiens]
Length = 975
Score = 54.3 bits (129), Expect = 2e-07
Identities = 76/388 (19%), Positives = 163/388 (42%), Gaps = 32/388 (8%)
Query: 52 HRYLQ-EVIDVLETDGHFREKLQAANAE-------DIKSGKLSRELDFVSHHVRTKLDEL 103
H+ L+ EVI + +T R++ + E + ++G ++RE+ + ++ +L
Sbjct: 431 HKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQL 490
Query: 104 KRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATR 163
K + + R L +A+ D + ++ L Q DP+++ D E L ++
Sbjct: 491 KGEVLRYKRKLREAQSDLNKT-RLRSGSALLQSQSSTEDPKDEPAELKPDSEDLSSQSSA 549
Query: 164 DLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPG 223
A + A+ + KR E +E ERR E+ KE ER+ E+Q+ + E + +
Sbjct: 550 SKASQEDANEIKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSAKD 609
Query: 224 SQAQ------------LKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTK 271
+ +K++ EL ++ K ++ D+ +L A K
Sbjct: 610 KEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKK 669
Query: 272 ELEKVYDPKNEEDDM--REMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRK----- 324
++ D + D+ +E +E + E ++ + ++++ L++ LA +++
Sbjct: 670 SKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALL 729
Query: 325 -EFGDTGEGWETVEMHPAYTEEELRRFEE---ELAAREAELNAKAQRLSQETEALGRSQG 380
E TG+ +E ++ ++LR ++ +L + + N + L +E E L
Sbjct: 730 SEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVL 789
Query: 381 RLEAQKRELQQAVLHMEQRKQQQQQQQG 408
L+ Q Q V +E+++ Q G
Sbjct: 790 TLKTQVDAQLQVVRKLEEKEHLLQSNIG 817
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 54.3 bits (129), Expect = 2e-07
Identities = 93/427 (21%), Positives = 170/427 (39%), Gaps = 63/427 (14%)
Query: 25 LAVPLERGAPNKEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQ---AANAEDIK 81
L VP R A N E D+ + +E I VL+ + +EKL E+
Sbjct: 1706 LIVP--RSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETV 1763
Query: 82 SGKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQV-----------D 130
S + ++ + E K+ E + L+ +++ + + +
Sbjct: 1764 SSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKN 1823
Query: 131 HLNLLKQFEHLDPQNQHTFEARDL-----ELLIQTATRDLAQYDAAHHEEFKRYEMLKEH 185
++ + E++ Q T + ++L E I+ L + H E + E+ ++
Sbjct: 1824 NIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEME--ELTSKY 1881
Query: 186 ERRRYLESL-GEEQRKEA-ERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLD--PN 241
E+ + L+ + G + E E EE+ + H PK+ + +AQ ++ +L G +
Sbjct: 1882 EKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKL-LSNMEAQHNDLEFKLAGAEREKQ 1940
Query: 242 RFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLR------ 295
+ + + D+ +QELE L +K YD + EE +E E+ L+
Sbjct: 1941 KLGKEIVRLQKDLRMLRKEHQQELEIL-----KKEYDQEREEKIKQEQEDLELKHNSTLK 1995
Query: 296 --MREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELR----- 348
MRE + Q+ +T++E + Q E E +E H T + L+
Sbjct: 1996 QLMREFNTQLAQKEQELEMTIKETINKAQEVEA-------ELLESHQEETNQLLKKIAEK 2048
Query: 349 ---------RFEEELAAREAELNAKAQRLSQETEALGRS-QGRLEAQKRELQQAVLHMEQ 398
R+EE L ARE E+ AK + L + E L + Q +LE ++ V ME
Sbjct: 2049 DDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMEL 2108
Query: 399 RKQQQQQ 405
+ Q Q+
Sbjct: 2109 QTQLAQK 2115
Score = 48.5 bits (114), Expect = 1e-05
Identities = 99/465 (21%), Positives = 180/465 (38%), Gaps = 104/465 (22%)
Query: 25 LAVPLE--RGAPNKEETPATESPDTGLYYHRYLQ-----EVIDVLETDGHFR-EKLQAAN 76
LAV LE + NKE T E T L ++ Q E + VL+ EKL+
Sbjct: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKC 649
Query: 77 AEDIKSGKLSRELDFVSHHVRTKLDELKRQEV---------SRLRMLLKAKMDAEQDPNV 127
++ ++ +E+ F +H L++ +V S L +LKA+ E++ +V
Sbjct: 650 EQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSV 709
Query: 128 QVDHLNLLKQ--FEHLDPQNQHTFEARD-----------------------LELLIQTAT 162
D + +KQ +D Q H + D LELL++
Sbjct: 710 LKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERD 769
Query: 163 RDLAQYDA--------------------AHHEEFKRYEMLKEHERRRYLESLGEEQRK-- 200
+ L ++ A A + F+ Y+ + + Y E L + Q+K
Sbjct: 770 KHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
Query: 201 --EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDG 258
E ER L +Q V +AQ K+V ELD + ++ +
Sbjct: 830 DLETERILLTKQ----------VAEVEAQKKDVCTELDA-----HKIQVQDLMQQLEKQN 874
Query: 259 VLDEQELEALFTKELEKVYDPKNEEDDMREMEEER----LRMREHVMKNVDTNQDRLVTL 314
EQ++++L K+ D E++ +++ E+ L+MRE K ++ +L
Sbjct: 875 SEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAK 934
Query: 315 EE---FLASTQRKEFGDTGEGWETVEM---------------HPAYTEEELRRFEEELAA 356
E+ L +F + + E V+ A ++EL EL+
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQ 994
Query: 357 REAELNAKAQRLSQETEA-LGRSQGRLEAQKRELQQAVLHMEQRK 400
+E + NAK ++Q A + + RLE ++E +++ + +R+
Sbjct: 995 KEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRE 1039
Score = 46.6 bits (109), Expect = 5e-05
Identities = 87/410 (21%), Positives = 161/410 (39%), Gaps = 79/410 (19%)
Query: 55 LQEVIDV-LETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQEVSRLRM 113
L +V D+ + D +EK+ A D S K S + +K ++ ++
Sbjct: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQI---QL 1467
Query: 114 LLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQH---------------TFEARDLELLI 158
LK+K E+D + +NLLK E LD QN+ + +LE +
Sbjct: 1468 ELKSKEAYEKD-----EQINLLK--EELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 159 QTATRDLAQYD----------AAHHEEFKRYEMLKEHERR------RYLESLGEEQR--- 199
++ T + + + + +E K Y K+ E + ++ + LGEE+
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 200 KEAERKLE-------------EQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRF--- 243
KEAE K+ E +++ EH ++V + +LK + + L+ +
Sbjct: 1581 KEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAEL 1640
Query: 244 NPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKN 303
K + I + +E E + K E N + RE E + + E +K+
Sbjct: 1641 KRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQERERE---VHILEEKLKS 1697
Query: 304 VDTNQDRLVTL----EEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREA 359
V+++Q + + + A T+++E G +T E E++ + L +E
Sbjct: 1698 VESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYE-------EKISVLQRNLTEKEK 1750
Query: 360 ELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGH 409
L QR+ QE E S + Q +E + H E ++ + Q GH
Sbjct: 1751 LL----QRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH 1796
Score = 34.7 bits (78), Expect = 0.19
Identities = 75/361 (20%), Positives = 148/361 (40%), Gaps = 59/361 (16%)
Query: 102 ELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLN--LLKQFEHLDPQNQHTFEAR-----DL 154
E+K +E+++LR +K ++ Q + ++ E Q T EAR ++
Sbjct: 378 EMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEM 437
Query: 155 ELLIQTATRDLAQYDAAHHEEFKRYE------MLKEHERR-RYLESLGEEQ--RKEAE-- 203
+ I+T + + + +E R + M K E + L+ L E++ RKE E
Sbjct: 438 DEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQELT 497
Query: 204 RKLEEQQRRHREHPKVNVPGSQAQ---LKEVWEELDGLDPNRFNPKTFFILHDINSDGVL 260
+KL+ ++R +E KV + SQ++ + + E+ + L + IL + +
Sbjct: 498 KKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRD 557
Query: 261 DEQELEALFTKELE-------KVYDPKNEEDDMR-EMEEERLRMREHVMKNVDTNQDRLV 312
+QE E T+ LE + + KN+ D+ +E E+ + + + V+ ++ L
Sbjct: 558 LQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELE 617
Query: 313 TLE-----------EFLASTQRKEFGDTGEGWET----------------VEMHPAYTEE 345
+L+ + L + E E E +E T E
Sbjct: 618 SLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEEMNEKTLE 677
Query: 346 ELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQ 405
+L + EL + +EL+ + + E L + + + K+EL+ M+++K QQ
Sbjct: 678 KLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELE---AKMDEQKNHHQQ 734
Query: 406 Q 406
Q
Sbjct: 735 Q 735
Score = 33.1 bits (74), Expect = 0.54
Identities = 80/406 (19%), Positives = 156/406 (38%), Gaps = 46/406 (11%)
Query: 36 KEETPATESPDTGLYYHRYLQEVIDVLETDGHFREKLQAANAEDIKSGK-----LSRELD 90
KEE P ES + + ++ L+ +E L E I+S K L+ E +
Sbjct: 260 KEENP--ESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317
Query: 91 FVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEH--------LD 142
+ + +L EL++ + L M K K+ + D NL++Q E
Sbjct: 318 ALQEQLDERLQELEK--IKDLHMAEKTKLITQLR-----DAKNLIEQLEQDKGMVIAETK 370
Query: 143 PQNQHTFEARDLEL------LIQTATRDLAQYDAAHHEEFKRYEML--------KEHERR 188
Q T E ++ E+ + Q T+ + E +E L K E R
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430
Query: 189 RYLESLGEEQRKEAERKLEE-----QQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRF 243
R L++ +EQ K E+ EE QQ R +V V + +E +L L
Sbjct: 431 RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEV-VDVMKKSSEEQIAKLQKLHEKEL 489
Query: 244 NPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKN 303
K + + + +++++ K + E++ + E L +++ +
Sbjct: 490 ARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILT 549
Query: 304 VDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNA 363
N+ R + E T+ E + E ++++ + +++ E E E+
Sbjct: 550 ESENKLRDLQQEAETYRTRILELESSLE--KSLQENKNQSKDLAVHLEAEKNKHNKEITV 607
Query: 364 KAQRLSQETEALGRSQGRLEAQKREL--QQAVLHMEQRKQQQQQQQ 407
++ E E+L Q L +K ++ QQ ME+ +++ +Q++
Sbjct: 608 MVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEK 653
Score = 30.0 bits (66), Expect = 4.6
Identities = 32/171 (18%), Positives = 69/171 (40%), Gaps = 15/171 (8%)
Query: 281 NEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHP 340
N + +E +RLR E + + LVT + L ++K G + +
Sbjct: 130 NSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSLRRI 189
Query: 341 AYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHMEQRK 400
A EEL+ ++ + E +A + Q L Q ++ K+ L+ ++++ K
Sbjct: 190 AELREELQMDQQAKKHLQEEFDASLEEKDQYISVL---QTQVSLLKQRLRNGPMNVDVLK 246
Query: 401 QQQQQQQGHKAPAAHPEGQL---KFHPDTDDVPVPAPAGDQKEVDTSEKKL 448
P P+ ++ + +P++D PV K ++T ++++
Sbjct: 247 ---------PLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRV 288
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 54.3 bits (129), Expect = 2e-07
Identities = 79/344 (22%), Positives = 148/344 (43%), Gaps = 62/344 (18%)
Query: 141 LDPQNQHTFEARDLELLIQTATRDLAQYDAAHHEEFKRY---EMLKEH----ERRRYLES 193
L+ +++ T E +L+ +Q ++ Q + E R E+ +H E L+
Sbjct: 613 LEQKSKLTIEVAELQRQLQLEVKN--QQNIKEERERMRANLEELRSQHNEKVEENSTLQQ 670
Query: 194 LGEEQRKEAERKLEE--QQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFIL 251
EE E + LEE Q + RE + + Q QL E+ +ELD + K
Sbjct: 671 RLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREK----- 725
Query: 252 HDINSDGVLDEQELEALFTKELEKVYDPKNEEDDM-REMEEERLRMREHVMKNVDTNQDR 310
G L E+ L+A ++L+ + K E++D+ R+ E E ++ + + V ++
Sbjct: 726 ------GALIEELLQA--KQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQE 777
Query: 311 LVTL-EEFLASTQ--RKEFGDTGEGWE-------TVEMHPAYTEEELRRFEEE---LAAR 357
+ L E++ A Q R+ + + E T E A TE ++ +EE L R
Sbjct: 778 MDKLKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGR 837
Query: 358 EAELNAKAQRLSQETEALGRSQGRL-------EAQKRELQQAVLHMEQRKQQQQQQQGHK 410
EL + +L ++ E L + + E + R+L++A++H RK++++ +
Sbjct: 838 SEELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVH--ARKEEKEAVSARR 895
Query: 411 APAAHPEGQLKFHPDTDDVPVPAPAGDQKEVDTSEKKLLERLPE 454
A E +L+ A G+ + +K+L E+L E
Sbjct: 896 A----LENELE-----------AAQGNLSQTTQEQKQLSEKLKE 924
Score = 43.1 bits (100), Expect = 5e-04
Identities = 76/376 (20%), Positives = 148/376 (39%), Gaps = 50/376 (13%)
Query: 69 REKLQAA--NAEDIKSGKLSRELDFVSHHVRTKL------------DELKRQEVSRLRML 114
RE ++ A N E + S + E D +R KL +EL+R+ R +
Sbjct: 793 RESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEELERRVAQLQRQI 852
Query: 115 LKAKMDAEQDPNVQVDHLNLLKQFE----HLDPQNQHTFEARD-LELLIQTATRDLAQYD 169
K D + + ++Q E H + + AR LE ++ A +L+Q
Sbjct: 853 EDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQGNLSQ-- 910
Query: 170 AAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLK 229
E+ + E LKE E ++KE R+L+ + R H + Q ++
Sbjct: 911 -TTQEQKQLSEKLKE-----------ESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMA 958
Query: 230 EVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREM 289
++ E T + + ++ + +EL + + EK + + +M
Sbjct: 959 DIVE--------ASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKM 1010
Query: 290 EEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRR 349
++E +R+ E +++ QD +T + L T + D E +++
Sbjct: 1011 QDE-MRLMEEELRDYQRAQDEALTKRQLLEQTLK----DLEYELEAKSHLKDDRSRLVKQ 1065
Query: 350 FEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQ---AVLHMEQRK-QQQQQ 405
E++++ E EL + +E + RS+ ++E + EL Q A +E K ++Q
Sbjct: 1066 MEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQ 1125
Query: 406 QQGHKAPAAHPEGQLK 421
+ K+ H EG +
Sbjct: 1126 NKDLKSRIIHLEGSYR 1141
Score = 38.9 bits (89), Expect = 0.010
Identities = 70/337 (20%), Positives = 145/337 (43%), Gaps = 45/337 (13%)
Query: 70 EKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELK---RQEVSRLRMLLKAK-MDAEQDP 125
EKLQ A+ +++ + S + ++ +LDE K R+E++ ++ LK K ++AE+
Sbjct: 951 EKLQKEMADIVEASRTS------TLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSR 1004
Query: 126 NVQV---DHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLA-QYDAAHHEEFKRYEM 181
+ D + L++ E L + EA L++ +DL + +A H + R +
Sbjct: 1005 LTAMKMQDEMRLME--EELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRL 1062
Query: 182 LKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPN 241
+K+ E ++ + E +LEE+ R + + + S+ Q++++ EL
Sbjct: 1063 VKQME----------DKVSQLEMELEEE-RNNSDLLSERISRSREQMEQLRNELLQERAA 1111
Query: 242 RFNPKTFFILHDINSDGVLDEQELEALFTK--ELEKVYDPKNE------EDDMREMEEER 293
R D+ D + E++ + L ++ LE Y E E + E+E+ R
Sbjct: 1112 R---------QDLECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELED-R 1161
Query: 294 LRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEE 353
L E N+ + RL + L E + + + + + ++ EEE
Sbjct: 1162 LESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEE 1221
Query: 354 LAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQ 390
+ E+ + L ++ + QG+L + K++L+
Sbjct: 1222 IDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR 1258
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 53.1 bits (126), Expect = 5e-07
Identities = 78/358 (21%), Positives = 157/358 (43%), Gaps = 38/358 (10%)
Query: 70 EKLQAANAEDIKS--GKLSRELDFVSHHVRTKLDELKRQEVSRLRMLLKAKMDAEQDPNV 127
E+ +AA+ +++ K +E + + L+ L+R+++ L M LK + + +
Sbjct: 845 EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME-LEMRLKEQQTEMEA--I 901
Query: 128 QVDHLNLLKQFEHLDPQNQHTFEARD---LELLIQTATRDLAQYDAAHHEEFKRYEMLKE 184
Q Q E Q Q E LE L+QT ++LA DA+ E R +M +
Sbjct: 902 QAQREEERTQAESALCQMQLETEKERVSLLETLLQTQ-KELA--DASQQLERLRQDMKVQ 958
Query: 185 HERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFN 244
+ + + + Q +EA+R+L+E R+HR+ L + EE L ++ +
Sbjct: 959 KLKEQETTGILQTQLQEAQRELKEAARQHRD-----------DLAALQEESSSLLQDKMD 1007
Query: 245 PKTFFILHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNV 304
+ + D+ S V + + + EK+ + + +E+E E+ + +M+
Sbjct: 1008 LQK--QVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME-- 1063
Query: 305 DTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAK 364
+ RL+ L+E S +++E + + + ++ +E+ +EA+ A+
Sbjct: 1064 --KEQRLLVLQE-ADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQ 1120
Query: 365 AQRLSQETEALGRSQGRLEAQ--KRELQQAVLHMEQRKQQQQ-------QQQGHKAPA 413
+L +E EA ++ +L A +E + A L + R + Q QQ G++A A
Sbjct: 1121 EAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQA 1178
Score = 45.1 bits (105), Expect = 1e-04
Identities = 62/339 (18%), Positives = 132/339 (38%), Gaps = 59/339 (17%)
Query: 96 VRTKLDELKRQEVSRLRMLLKAKMDAE---QDPNVQVDHLNLLKQFEHLDPQNQHTFEAR 152
+R ++ EL++Q + L +D + Q+ ++Q + + L++ + + R
Sbjct: 1440 LRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQER 1499
Query: 153 DLELLIQTATRDLAQYDAAHHEEFKRYEMLKEHERRRYLES------------------- 193
+ +L +Q + D +++L+ ++ + +ES
Sbjct: 1500 EQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLA 1559
Query: 194 --LGEEQRK-EAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFI 250
L E K E ++KL ++ RE +V + L+E +EL
Sbjct: 1560 LELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQ--------- 1610
Query: 251 LHDINSDGVLDEQELEALFTKELEKVYDPKNEEDDMREMEEERLRMREHVMKNVDTNQDR 310
+HD+ S + +EL+ + E RE EE R +EH+ ++++
Sbjct: 1611 IHDLESHSTVLARELQ-----------ERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 311 LVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQ 370
L+ +E + + + T EE+L + + L R EL + Q + +
Sbjct: 1660 LMLQKERIQVLEDQRTRQT-----------KILEEDLEQIKLSLRERGRELTTQRQLMQE 1708
Query: 371 ETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGH 409
E +G +AQ+ L+ L + ++++ + QQ H
Sbjct: 1709 RAE---EGKGPSKAQRGSLEHMKLILRDKEKEVECQQEH 1744
Score = 44.3 bits (103), Expect = 2e-04
Identities = 87/388 (22%), Positives = 150/388 (38%), Gaps = 45/388 (11%)
Query: 53 RYLQEVIDVLETDGHFREKLQAANAEDIKSGKLSRELDFVSHHVRTKLDELKRQ----EV 108
R +QE ++ +LQA + + + L + + L E ++Q EV
Sbjct: 726 RAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEV 785
Query: 109 SR--LRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLA 166
++ L + ++ A++ +V L L E + + AR L Q L
Sbjct: 786 TKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALE 845
Query: 167 QYDAAHHEEFKRYEMLKEHER-------RRYLESLGEEQRKEAERKLEEQQ--------R 211
Q AAH +E + E ER + LESL E ++ E E +L+EQQ +
Sbjct: 846 QQKAAHEKEVNQLREKWEKERSWHQQELAKALESL-EREKMELEMRLKEQQTEMEAIQAQ 904
Query: 212 RHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFF----ILHDINSD---GVLDEQE 264
R E + Q QL+ E + L+ K L + D L EQE
Sbjct: 905 REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQE 964
Query: 265 LEALFTKELEKVYDPKNE-----EDDMREMEEER---LRMREHVMKNVDTNQDRLVTLEE 316
+ +L++ E DD+ ++EE L+ + + K V+ + +LV ++
Sbjct: 965 TTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024
Query: 317 FLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALG 376
+QR + E + + +E E E A+ L K QRL EA
Sbjct: 1025 ----SQRLVEQEVQEKLRETQEYNRIQKE----LEREKASLTLSLMEKEQRLLVLQEADS 1076
Query: 377 RSQGRLEAQKRELQQAVLHMEQRKQQQQ 404
Q L A ++++Q+A ++ Q +
Sbjct: 1077 IRQQELSALRQDMQEAQGEQKELSAQME 1104
Score = 41.2 bits (95), Expect = 0.002
Identities = 83/370 (22%), Positives = 147/370 (39%), Gaps = 58/370 (15%)
Query: 55 LQEVIDVLETDGHFREK----LQAANAEDIKSGKL-SRELDFVSHHVRTKLDELKRQEVS 109
L+EV+ L + +EK LQ AE + ++ +R L + L E + QE+
Sbjct: 1885 LEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKE-RDQELE 1943
Query: 110 RLRMLLKAKMDAEQDPNVQVDHLN--LLKQFEHLDPQNQHTFEARDLELLIQTATRDL-A 166
LR ++ E+ + + L L K L + QH E +L ++ +T L A
Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003
Query: 167 QYDA--AHHEEFKRYEMLKEHERR----RYLESLGEEQRKEAERKLEEQQRRHREHPKVN 220
DA AH + + ++E E + RY E + + Q+ A+R +++ RH++ +
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQR---DEELRHQQEREQL 2060
Query: 221 VPGSQAQL--KEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALF--TKELEKV 276
+ S AQ + + +E L R +E+E+ L +EL+
Sbjct: 2061 LEKSLAQRVQENMIQEKQNLGQER------------------EEEEIRGLHQSVRELQLT 2102
Query: 277 YDPKNEEDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETV 336
+ + E+E L +RE +N LE S + + +++
Sbjct: 2103 ---------LAQKEQEILELRETQQRN---------NLEALPHSHKTSPMEEQSLKLDSL 2144
Query: 337 EMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAVLHM 396
E E L+ + ARE E KAQ L+ S L+ LQ +VL
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLER 2204
Query: 397 EQRKQQQQQQ 406
+ +Q+ Q +
Sbjct: 2205 DSEQQRLQDE 2214
Score = 38.5 bits (88), Expect = 0.013
Identities = 85/403 (21%), Positives = 156/403 (38%), Gaps = 60/403 (14%)
Query: 56 QEVIDVLETDGHFREKLQAANAEDIKSG--KLSRELDFVSHHVRTKLDELK------RQE 107
+E I VLE + K+ + E IK + REL ++ + +E K R
Sbjct: 1664 KERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKAQRGS 1723
Query: 108 VSRLRMLLKAKMDAEQDPNVQVDHLNLLKQF-EHLDPQNQHTF-EARDLELLIQTATRDL 165
+ ++++L+ D E++ Q +H++ L++ + L+ Q Q + + LL+ +++
Sbjct: 1724 LEHMKLILR---DKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEI 1780
Query: 166 AQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQ 225
E ++ E LKE + L+ E QR A+R +Q+ + + G +
Sbjct: 1781 VVLQQQLQEAREQGE-LKEQSLQSQLD---EAQRALAQR---DQELEALQQEQQQAQGQE 1833
Query: 226 AQLKEVWEELDG-LDPNRFNPKTFF-ILHDINSDGVLDEQEL--EALFTKELEKVYDPKN 281
++KE + L G L+ K L D E+EL E + LE+V
Sbjct: 1834 ERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLR 1893
Query: 282 EEDDMREMEEERLRMREHVMKNVDTNQ------------------DRLVTLEEFLASTQ- 322
E RE E+ L +++ + ++ +R LE A +Q
Sbjct: 1894 AES--REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQS 1951
Query: 323 ---------------RKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQR 367
++ G + E H E R E A +A L+A
Sbjct: 1952 SRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAH 2011
Query: 368 LSQETEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHK 410
Q EAL +G ++ Q Q+ V ++Q Q+ ++ H+
Sbjct: 2012 SRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ 2054
Score = 33.9 bits (76), Expect = 0.32
Identities = 36/152 (23%), Positives = 69/152 (45%), Gaps = 16/152 (10%)
Query: 262 EQELEALFTK------ELEKVYDPKNE-EDDMREMEEERLRMREHVMKNVDTNQDRLVTL 314
E+ EAL+ K +L+K + E + D+R+++EE +E + K + ++
Sbjct: 651 EKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEE----KEEIQKKLSESRH----- 701
Query: 315 EEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEA 374
++ A+TQ ++ + E V +E L R + L R + Q L+++ +
Sbjct: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG 761
Query: 375 LGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQ 406
L ++ LE+ E QQ +E K Q + Q
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQ 793
Score = 30.0 bits (66), Expect = 4.6
Identities = 50/267 (18%), Positives = 107/267 (40%), Gaps = 42/267 (15%)
Query: 177 KRYEMLKE-HERRR---YLESLGEEQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVW 232
K E+ KE HER + L+S G+ ++ E + ++ E + K N + +K +
Sbjct: 252 KTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQN-EDYEKMIKALR 310
Query: 233 EELDGLDPNRFNPKTFFILHDINSDGVLDEQELEAL-FTKELEKVYDPKNEEDDMREMEE 291
E ++ L+ N T + H+ + E++L K++ +V + + E
Sbjct: 311 ETVEILETNH----TELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHE 366
Query: 292 ERLRMREHVMKNVD-TNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAYTEEELRRF 350
L + + D + D+ +TL + + +R+ D + + +++ ++
Sbjct: 367 NSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426
Query: 351 EEE-----------------LAAREAELNAKAQRLSQETEALGRSQGRLEAQKRELQQAV 393
EEE LA + +L + LS+E E L +++ L Q L+Q
Sbjct: 427 EEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEA 486
Query: 394 LHMEQ--------------RKQQQQQQ 406
+ + +K++QQ++
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQQEE 513
Score = 29.6 bits (65), Expect = 6.0
Identities = 53/271 (19%), Positives = 110/271 (40%), Gaps = 30/271 (11%)
Query: 158 IQTATRDLAQYDAAHHEEFKRYE---------MLKEHERRRYLESL---GEEQRKEAERK 205
+ T +DL + + + EE ++E +++ HE L+S E QR EA+ +
Sbjct: 1283 VHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGE 1342
Query: 206 LEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQEL 265
E Q +E+ V QA + E + + +T + ++ V E+E
Sbjct: 1343 RELLQAA-KENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERER 1401
Query: 266 EALFTKELE-KVYDPKNEEDDMR-------EMEEERLRMREHVMKNVDTNQDRLVTLEEF 317
++ E KV K ++++ E EEE +R + + ++ ++ E
Sbjct: 1402 AQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQE-LEKQREMQKAALEL 1460
Query: 318 LASTQRKEFGDTGEGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQETEALGR 377
L+ +K + E ++ EL + L + + Q+L+ + E +
Sbjct: 1461 LSLDLKKRNQEVDLQQEQIQ--------ELEKCRSVLEHLPMAVQEREQKLTVQREQIRE 1512
Query: 378 SQGRLEAQKRELQQAVLHMEQRKQQQQQQQG 408
+ E Q+ L+ +L +E++ Q + Q+G
Sbjct: 1513 LEKDRETQRNVLEHQLLELEKKDQMIESQRG 1543
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 52.8 bits (125), Expect = 7e-07
Identities = 79/371 (21%), Positives = 154/371 (41%), Gaps = 32/371 (8%)
Query: 112 RMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQTATRDLAQYDAA 171
R L +++ + +P Q H L + HL+ Q Q + + Q + ++ +
Sbjct: 87 RELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQ-----QLSQLQQEKHQSV 141
Query: 172 HHEEFKRYEMLKEHERRRYLESLGEEQR-KEAERKLEEQQRRHREHPKVNVPGSQAQLKE 230
HH+E K L +++ + + E+QR ++ + +L+ QQ + ++ V Q QL++
Sbjct: 142 HHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQ-----VLQQQEQLQQ 196
Query: 231 VWEELDGLDPNRFNPKTFFILHDINS--DGVLDEQELEALFTKELEKVYDPKNEEDDMRE 288
+E L + + +L +Q+ + ++L + + + +
Sbjct: 197 QVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQ 256
Query: 289 MEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEF-GDTGEGWETVEMHPAYTE-EE 346
++ +L+ + + Q L+ +E L Q+++ E + ++ P E EE
Sbjct: 257 QQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316
Query: 347 LRRFEEELA----AREAELNAKAQRLSQETEALGRSQGRLEAQ---KRELQQAVLHMEQR 399
E EL E EL + Q L ++ E L R Q + + Q + ELQQ +EQ+
Sbjct: 317 EEEVELELMPVDLGSEQELEQQRQELERQQE-LERQQEQRQLQLKLQEELQQLEQQLEQQ 375
Query: 400 KQQQQQQQGH------KAPAAHPEGQLKFHPDTDDVP---VPAPAGDQKEVDTSEKKLLE 450
+QQ +QQ+ + A E QL+ P ++ VPA G V + ++
Sbjct: 376 QQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLELVPAAGGGGAAVPGAPAAVVV 435
Query: 451 RLPEVEVPQHL 461
P V Q L
Sbjct: 436 APPGYVVVQEL 446
Score = 45.8 bits (107), Expect = 8e-05
Identities = 58/277 (20%), Positives = 120/277 (43%), Gaps = 18/277 (6%)
Query: 197 EQRKEAERKLEEQQRRHREHPKVNVPGSQAQLKEVWEELDGLDPNRFNPKTFFILHDINS 256
E+ + +R+L+ QQ + P+ Q Q + EL P + + L
Sbjct: 80 EETRPGQRELQLQQLEQQPEPQQQPQHEQLQQPQPHLELQQ-QPQQDGQQQLSQLQQEKH 138
Query: 257 DGVLDEQELEALFTKELEKVYDPKNEEDDMR-EMEEERLRMREHVMKNVDTNQDRLV--T 313
V ++ L ++ P+ ++ R + ++E+L+ ++ + V Q++L
Sbjct: 139 QSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQV 198
Query: 314 LEEFLASTQRKEFGDTG--EGWETVEMHPAYTEEELRRFEEELAAREAELNAKAQRLSQE 371
E+ L Q+++ + E ++ ++E + +++L + + + Q L Q+
Sbjct: 199 QEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQ 258
Query: 372 TEALGRSQGRLEAQKRELQQAVLHMEQRKQQQQQQQGHKAPAAHPEGQLKFHP------D 425
L Q LE Q+ +LQQ +L +Q + QQQQQQ Q + P +
Sbjct: 259 QAQL--QQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEE 316
Query: 426 TDDVP---VPAPAGDQKEVDTSEKKLLERLPEVEVPQ 459
++V +P G ++E++ +++ LER E+E Q
Sbjct: 317 EEEVELELMPVDLGSEQELE-QQRQELERQQELERQQ 352
Score = 34.3 bits (77), Expect = 0.24
Identities = 30/144 (20%), Positives = 66/144 (45%), Gaps = 4/144 (2%)
Query: 100 LDELKRQEVSRLRMLLKAKMDAEQDPNVQVDHLNLLKQFEHLDPQNQHTFEARDLELLIQ 159
L++ + Q +L + + ++ +Q + L+Q + L P E ++EL +
Sbjct: 267 LEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQ-QQLQPPPLEPEEEEEVELELM 325
Query: 160 TATRDLAQYDAAHHEEFKRYEMLKEHERRRYLESLGEEQRKEAERKLEEQQRRHREHP-- 217
Q +E +R + L+ + +R L+ +E+ ++ E++LE+QQ++ +
Sbjct: 326 PVDLGSEQELEQQRQELERQQELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQ 385
Query: 218 -KVNVPGSQAQLKEVWEELDGLDP 240
++ AQ +EV EL + P
Sbjct: 386 LELTPVELGAQQQEVQLELTPVQP 409
>gi|38569484 kinesin family member 21A [Homo sapiens]
Length = 1661
Score = 52.0 bits (123), Expect = 1e-06
Identities = 58/255 (22%), Positives = 116/255 (45%), Gaps = 46/255 (18%)
Query: 177 KRYEMLKEHERRRYLESLGEEQRKEAER-KLEEQQRRHREHPKVNVPGSQA------QLK 229
K E LK E+R+ G+E + ++ K EE+ RE+ ++ V SQ + +
Sbjct: 543 KDLEKLKRKEKRKKKSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEVSDHEDEEE 602
Query: 230 EVWEELDGLDPNRFNPKTFFILHDINSDGVLDEQELEALFT-------KELEKVYDPKNE 282
E EE D +D + ++ D SD + Q A T K ++++ + +
Sbjct: 603 EEEEEEDDIDGGESSDES-----DSESDEKANYQADLANITCEIAIKQKLIDELENSQKR 657
Query: 283 EDDMREMEEERLRMREHVMKNVDTNQDRLVTLEEFLASTQRKEFGDTGEGWETVEMHPAY 342
+++ EE+L M +H +++ +D+++ + L S + +Y
Sbjct: 658 LQTLKKQYEEKLMMLQHKIRDTQLERDQVL---QNLGSVE------------------SY 696
Query: 343 TEEELRRFEEELAAREAELNAKAQRL---SQETEALGRSQGRLEAQKRELQQAVLHMEQR 399
+EE+ ++ E + +N + QRL +E L ++Q + E Q ++LQQ V+ M++
Sbjct: 697 SEEKAKKVRSEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKT 756
Query: 400 K---QQQQQQQGHKA 411
K +Q +++ KA
Sbjct: 757 KVRLMKQMKEEQEKA 771
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,600,904
Number of Sequences: 37866
Number of extensions: 951141
Number of successful extensions: 12512
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 255
Number of HSP's successfully gapped in prelim test: 758
Number of HSP's that attempted gapping in prelim test: 6711
Number of HSP's gapped (non-prelim): 3451
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.