Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 19924156
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19924156 regulatory factor X-associated ankyrin-containing
protein isoform b [Homo sapiens]
(237 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19924156 regulatory factor X-associated ankyrin-containing pr... 479 e-135
gi|4506499 regulatory factor X-associated ankyrin-containing pro... 457 e-129
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 212 2e-55
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 84 8e-17
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 77 1e-14
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 76 3e-14
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 76 3e-14
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 76 3e-14
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 76 3e-14
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 76 3e-14
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 75 4e-14
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 75 6e-14
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 73 2e-13
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 73 2e-13
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 73 2e-13
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 73 2e-13
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 72 5e-13
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 72 5e-13
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 71 7e-13
gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain ... 71 7e-13
gi|34304381 inversin isoform a [Homo sapiens] 70 1e-12
gi|34304379 inversin isoform b [Homo sapiens] 70 1e-12
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 69 3e-12
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 69 3e-12
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 69 3e-12
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 69 3e-12
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 69 3e-12
gi|62420875 integrin-linked kinase [Homo sapiens] 69 4e-12
gi|62420873 integrin-linked kinase [Homo sapiens] 69 4e-12
gi|4758606 integrin-linked kinase [Homo sapiens] 69 4e-12
>gi|19924156 regulatory factor X-associated ankyrin-containing
protein isoform b [Homo sapiens]
Length = 237
Score = 479 bits (1232), Expect = e-135
Identities = 237/237 (100%), Positives = 237/237 (100%)
Query: 1 MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS 60
MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS
Sbjct: 1 MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS 60
Query: 61 PQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFL 120
PQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFL
Sbjct: 61 PQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFL 120
Query: 121 LEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 180
LEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV
Sbjct: 121 LEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 180
Query: 181 KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE 237
KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE
Sbjct: 181 KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE 237
>gi|4506499 regulatory factor X-associated ankyrin-containing
protein isoform a [Homo sapiens]
Length = 260
Score = 457 bits (1177), Expect = e-129
Identities = 236/260 (90%), Positives = 236/260 (90%), Gaps = 23/260 (8%)
Query: 1 MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS 60
MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS
Sbjct: 1 MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS 60
Query: 61 PQ-GSSLKHSTTLTNRQRGNEVSALPATLDC----------------------DNLVNKP 97
PQ GSSLKHSTTLTNRQRGNEVSALPATLD DNLVNKP
Sbjct: 61 PQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKP 120
Query: 98 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 157
DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD
Sbjct: 121 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 180
Query: 158 VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 217
VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ
Sbjct: 181 VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 240
Query: 218 VIENHILKLFQSNLVPADPE 237
VIENHILKLFQSNLVPADPE
Sbjct: 241 VIENHILKLFQSNLVPADPE 260
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
Length = 313
Score = 212 bits (540), Expect = 2e-55
Identities = 110/187 (58%), Positives = 130/187 (69%), Gaps = 21/187 (11%)
Query: 64 SSLKHSTTLTNRQRGNEVSALP---------------------ATLDCDNLVNKPDERGF 102
S +K STTLTN+ RGNEVS P ++ +N++N DE GF
Sbjct: 124 SPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQENVINHTDEEGF 183
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL+WA+A G+I V FLL+ GADP +L K RESALSLA + GYTDIV +LL+ VD+N
Sbjct: 184 TPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVNE 243
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
YDWNGGTPLLYAV GNHVKCV+ LL GAD T E DSGY MDLAVALGYR VQQVIE+H
Sbjct: 244 YDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIESH 303
Query: 223 ILKLFQS 229
+LKL Q+
Sbjct: 304 LLKLLQN 310
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 84.3 bits (207), Expect = 8e-17
Identities = 51/158 (32%), Positives = 82/158 (51%), Gaps = 1/158 (0%)
Query: 66 LKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA 125
L + T L + + V + L C + D G+T L+WA G + V LL GA
Sbjct: 69 LDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSHGA 128
Query: 126 DPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEA 185
+P + + A+ G+ DIV LLL+ +N D G TPL++A R H++CV+
Sbjct: 129 NPSVTGLYSVYPIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKH 188
Query: 186 LLARGADLTTEADSGYTPMDLAVALGY-RKVQQVIENH 222
LLA GAD+ E + T + +AV GY + V+++++ +
Sbjct: 189 LLAMGADVDQEGANSMTALIVAVKGGYTQSVKEILKRN 226
Score = 72.8 bits (177), Expect = 2e-13
Identities = 44/126 (34%), Positives = 69/126 (54%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN D+ G TPL+WA+ G +E V+ LL GAD +AL +A GGYT V +
Sbjct: 163 VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANSMTALIVAVKGGYTQSVKEI 222
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
L+R+ ++N+ D +G T L+ A + H + V+ LL G + SG T + AV G+
Sbjct: 223 LKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHV 282
Query: 214 KVQQVI 219
++ + +
Sbjct: 283 EIVRAL 288
Score = 69.7 bits (169), Expect = 2e-12
Identities = 50/172 (29%), Positives = 84/172 (48%), Gaps = 5/172 (2%)
Query: 48 EPVNPEPDASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIW 107
E + P+ +++ G+ T L + + LD VN PD G T LI
Sbjct: 221 EILKRNPNVNLTDKDGN-----TALMIASKEGHTEIVQDLLDAGTYVNIPDRSGDTVLIG 275
Query: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
A G +E VR LL+ AD I ++ ++AL A G +V +L+ + D I +G
Sbjct: 276 AVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEICTKDG 335
Query: 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
TPL+ A + +++ VE LL +GA ++ G TP+ +A+ RK+ +++
Sbjct: 336 ETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELL 387
Score = 56.2 bits (134), Expect = 2e-08
Identities = 43/151 (28%), Positives = 75/151 (49%)
Query: 69 STTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH 128
S ++ N + AL A L+ V++ +E G TPL+ A+ G +E V+ L++ GA+ +
Sbjct: 6 SQSVINYVEEENIPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCN 65
Query: 129 ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLA 188
+ + +AL AS G+ IV LL+ V++ D G T L++A VE LL+
Sbjct: 66 LEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLS 125
Query: 189 RGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
GA+ + P+ A G+ + ++
Sbjct: 126 HGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
Score = 54.3 bits (129), Expect = 9e-08
Identities = 42/140 (30%), Positives = 61/140 (43%), Gaps = 3/140 (2%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L RG V + A L ++ + T L WA G VR +L+ D I
Sbjct: 271 TVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWAVEKGNATMVRDILQCNPDTEI 330
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
K+ E+ L A+ ++V LLL++ ++ D G TPL A+RG K E LL
Sbjct: 331 CTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGDTPLHIAIRGRSRKLAELLLRN 390
Query: 190 GAD---LTTEADSGYTPMDL 206
D L +G TP ++
Sbjct: 391 PKDGRLLYRPNKAGETPYNI 410
Score = 51.2 bits (121), Expect = 8e-07
Identities = 32/114 (28%), Positives = 56/114 (49%)
Query: 104 PLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIY 163
P+IWA+ G + V LL+ GA + K + L A+ G+ + V LL D++
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
Query: 164 DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 217
N T L+ AV+G + + V+ +L R ++ G T + +A G+ ++ Q
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Score = 39.7 bits (91), Expect = 0.002
Identities = 30/109 (27%), Positives = 52/109 (47%)
Query: 114 IETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
I ++ LLE D + ++ L +A+ G +IV L++ + N+ D + T L+
Sbjct: 18 IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77
Query: 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
A + HV VE LL G +L G+T + A G V +++ +H
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH 126
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sapiens]
Length = 2603
Score = 77.4 bits (189), Expect = 1e-14
Identities = 66/228 (28%), Positives = 101/228 (44%), Gaps = 25/228 (10%)
Query: 10 LIQTQQ-----TPASELGDPEDPGEEAADG-----SDTVVLSLFPCTPEPVNPEPDASVS 59
L +TQQ +PA L D D A G S+T S+ +P P P +S
Sbjct: 1003 LTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTPSPIIS 1062
Query: 60 SPQ------------GSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIW 107
+ H T LT G + L+ + D++GFTPLI
Sbjct: 1063 PSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLIL 1122
Query: 108 ASAFGEIETVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWN 166
A+ G + V LL+ GAD ++ +++ LSLA +GG ++V LLL R + + +
Sbjct: 1123 AATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVS 1182
Query: 167 GGTPLLYAVRGNHVKCVEALLARGADLTTEADS--GYTPMDLAVALGY 212
TPL A G +V ++ LL GA++ + S G +P+ LA G+
Sbjct: 1183 DYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1230
Score = 74.7 bits (182), Expect = 6e-14
Identities = 42/121 (34%), Positives = 71/121 (58%), Gaps = 1/121 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL+ A+ G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 221
G TPL+ A R HV V+ L+++GA++ T A++ +T + LA A G+ V +++
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 222 H 222
H
Sbjct: 686 H 686
Score = 68.6 bits (166), Expect = 5e-12
Identities = 49/145 (33%), Positives = 70/145 (48%), Gaps = 1/145 (0%)
Query: 69 STTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH 128
+T LT G V + L+ + +E G TPL+ A + G +E R LLE GA +
Sbjct: 335 NTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN 394
Query: 129 ILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 187
+ E +ESAL+LA G+ ++V LLE D T L+ A HV+ LL
Sbjct: 395 THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL 454
Query: 188 ARGADLTTEADSGYTPMDLAVALGY 212
GA + ADS +P+ LA G+
Sbjct: 455 DSGAQVNMPADSFESPLTLAACGGH 479
Score = 67.4 bits (163), Expect = 1e-11
Identities = 53/169 (31%), Positives = 82/169 (48%), Gaps = 10/169 (5%)
Query: 71 TLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI- 129
TL Q EV +L LD V + G TPL+ A++ G E R LL+ GAD +
Sbjct: 1257 TLACFQGRTEVVSL--LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1314
Query: 130 -LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLA 188
+ R++AL++A+ G+ LL+ R I++ + G TPL A G H+ V+ L+
Sbjct: 1315 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1374
Query: 189 RGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE 237
GAD+ + TP+ A G+ KV + + + N P+D E
Sbjct: 1375 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEV------NQFPSDSE 1417
Score = 65.5 bits (158), Expect = 4e-11
Identities = 38/104 (36%), Positives = 54/104 (51%)
Query: 112 GEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPL 171
G +E VRFLLE GAD E +AL A G+ ++ LLL+ +N+ + +PL
Sbjct: 412 GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 471
Query: 172 LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
A G HV+ L+ RGA L D GYTP+ A G+ ++
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Score = 65.5 bits (158), Expect = 4e-11
Identities = 42/122 (34%), Positives = 67/122 (54%), Gaps = 2/122 (1%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+K DE T L+ A G +E R LL+ GA ++ A ES L+LA+ GG+ ++ LL+
Sbjct: 429 HKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA-DSGYTPMDLAVALGYR 213
ER + + G TPL+ A R H + V LL +GA++ + ++ T + LA G+
Sbjct: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
Query: 214 KV 215
+V
Sbjct: 548 EV 549
Score = 63.9 bits (154), Expect = 1e-10
Identities = 36/107 (33%), Positives = 58/107 (54%)
Query: 92 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 151
N+ ++ + TPL+ A+ G ++ V+ LL AD + + +AL+ A GGY D+V
Sbjct: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
Query: 152 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
+LLE I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 352 VLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Score = 61.6 bits (148), Expect = 6e-10
Identities = 40/113 (35%), Positives = 60/113 (53%), Gaps = 1/113 (0%)
Query: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
A + G++ VR LL G + +E ES L LA + GY ++ +LL ++ G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 168 G-TPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
TPL+ A G HVK V+ LLA AD+ ++ +G T + A A GY V +V+
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Score = 60.1 bits (144), Expect = 2e-09
Identities = 43/141 (30%), Positives = 70/141 (49%), Gaps = 1/141 (0%)
Query: 80 EVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SAL 138
+V+A+ L VN+ E G + L A + G E + LL A+ + + + L
Sbjct: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
Query: 139 SLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
A+ GG+ IV LLL D+N G T L YA G +V V+ LL GA + +
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 199 SGYTPMDLAVALGYRKVQQVI 219
+G+TP+ A + G+ +V +++
Sbjct: 366 NGHTPLMEAGSAGHVEVARLL 386
Score = 58.2 bits (139), Expect = 6e-09
Identities = 33/86 (38%), Positives = 52/86 (60%), Gaps = 1/86 (1%)
Query: 135 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 194
++AL+LA GG+ ++V LLER I D G TPL+ A HV VE LL GAD+
Sbjct: 1084 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 1143
Query: 195 TEAD-SGYTPMDLAVALGYRKVQQVI 219
+++ + TP+ LA + G ++V +++
Sbjct: 1144 AQSERTKDTPLSLACSGGRQEVVELL 1169
Score = 58.2 bits (139), Expect = 6e-09
Identities = 44/155 (28%), Positives = 76/155 (49%), Gaps = 5/155 (3%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKP--DERGFTPLIWASAFGEIETVRFLLEWGADP 127
T L+ G V+ + L+ +N + G +PL+ A+ G V+ LL+ G+D
Sbjct: 1185 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 1244
Query: 128 HI-LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
+ + R +AL+LA G T++V LLL+R ++ G TPL+ A G + + L
Sbjct: 1245 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1304
Query: 187 LARGADLTTE--ADSGYTPMDLAVALGYRKVQQVI 219
L +GAD+ S T + +A G+ K +++
Sbjct: 1305 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1339
Score = 49.7 bits (117), Expect = 2e-06
Identities = 38/119 (31%), Positives = 52/119 (43%), Gaps = 1/119 (0%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH- 128
T LT L + E G TPL+ A+ G + TV+FL+ GA+ +
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 129 ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 187
A + LSLA GG+ +V LLL D +G T L+ A +G H V LL
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 48.9 bits (115), Expect = 4e-06
Identities = 42/151 (27%), Positives = 65/151 (43%), Gaps = 1/151 (0%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L G V + L VN G T L +A A G ++ V+ LLE GA
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWN-GGTPLLYAVRGNHVKCVEALLA 188
+ + L A + G+ ++ LLLE IN + + L A H++ V LL
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 189 RGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
GAD + D +T + A G+ +V +++
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Score = 46.6 bits (109), Expect = 2e-05
Identities = 44/181 (24%), Positives = 69/181 (38%), Gaps = 31/181 (17%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L V LD VN P + +PL A+ G +E L+E GA
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINI--------------------------- 162
+ E + L A+ G+ ++V LLL + +IN
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
Query: 163 ----YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ TPL+ A + H++ V+ LLA GA++ +G T + A G+ V V
Sbjct: 556 AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615
Query: 219 I 219
+
Sbjct: 616 L 616
Score = 36.6 bits (83), Expect = 0.019
Identities = 32/106 (30%), Positives = 44/106 (41%), Gaps = 6/106 (5%)
Query: 56 ASVSSPQGSSLKHS-----TTLTNRQRGNEVSALPATLDCDNLVNKPDERG-FTPLIWAS 109
A V G+ L+H T L R V + + VN+ T L A
Sbjct: 613 ADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC 672
Query: 110 AFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLE 155
A G + V LL GADP K+ + L A+ GG+T +V LL+
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 75.9 bits (185), Expect = 3e-14
Identities = 50/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 80 EVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SAL 138
+V+A+ LD VN+ E G + L A + G E + LL A+ + + + L
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 139 SLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
AS+GGY DIV LLL D D+N G T L YA G V V+ LL GA++ +
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 199 SGYTPMDLAVALGYRKVQQVIENH 222
+G+TP+ A + G+ +V +V+ +H
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDH 360
Score = 68.9 bits (167), Expect = 4e-12
Identities = 53/159 (33%), Positives = 77/159 (48%), Gaps = 4/159 (2%)
Query: 55 DASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEI 114
DA V+S + +T LT G V + L+ + +E G TPL+ A++ G +
Sbjct: 295 DADVNSQSATG---NTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 115 ETVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
E R LL+ GA + + E +ESAL+LA G+ D+V LLE D T L+
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
A HV+ LL GA + ADS +P+ LA G+
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
Score = 67.8 bits (164), Expect = 8e-12
Identities = 43/122 (35%), Positives = 69/122 (56%), Gaps = 2/122 (1%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+K DE T L+ A G +E R LL+ GA ++ A ES L+LA+ GG+ ++ LL+
Sbjct: 400 HKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 458
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA-DSGYTPMDLAVALGYR 213
ER ++ + G TPL+ A R H + V LLA+GA++ + ++ T + LA G+
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518
Query: 214 KV 215
+V
Sbjct: 519 EV 520
Score = 64.7 bits (156), Expect = 7e-11
Identities = 36/107 (33%), Positives = 60/107 (56%)
Query: 92 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 151
N+ ++ ++ TPL+ AS+ G ++ V+ LL AD + + +AL+ A GG+ DIV
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 152 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
+LL +I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Score = 64.7 bits (156), Expect = 7e-11
Identities = 48/165 (29%), Positives = 83/165 (50%), Gaps = 7/165 (4%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIE 115
A V+ P S + LT G V ++ + + ++ G+TPL+ A+ G E
Sbjct: 429 AQVNMPADS---FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEE 485
Query: 116 TVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
V LL GA+ + +E +E+AL+LA GG++++ L++ DI + TPL+ A
Sbjct: 486 MVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEA 542
Query: 175 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
+ H++ V+ LLA GA++ +G T + A G+ V V+
Sbjct: 543 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 45.4 bits (106), Expect = 4e-05
Identities = 22/59 (37%), Positives = 36/59 (61%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 161
TPL+ AS G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 75.9 bits (185), Expect = 3e-14
Identities = 50/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 80 EVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SAL 138
+V+A+ LD VN+ E G + L A + G E + LL A+ + + + L
Sbjct: 206 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 265
Query: 139 SLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
AS+GGY DIV LLL D D+N G T L YA G V V+ LL GA++ +
Sbjct: 266 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 325
Query: 199 SGYTPMDLAVALGYRKVQQVIENH 222
+G+TP+ A + G+ +V +V+ +H
Sbjct: 326 NGHTPLMEAASAGHVEVARVLLDH 349
Score = 68.9 bits (167), Expect = 4e-12
Identities = 53/159 (33%), Positives = 77/159 (48%), Gaps = 4/159 (2%)
Query: 55 DASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEI 114
DA V+S + +T LT G V + L+ + +E G TPL+ A++ G +
Sbjct: 284 DADVNSQSATG---NTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 340
Query: 115 ETVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
E R LL+ GA + + E +ESAL+LA G+ D+V LLE D T L+
Sbjct: 341 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 400
Query: 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
A HV+ LL GA + ADS +P+ LA G+
Sbjct: 401 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 439
Score = 67.8 bits (164), Expect = 8e-12
Identities = 43/122 (35%), Positives = 69/122 (56%), Gaps = 2/122 (1%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+K DE T L+ A G +E R LL+ GA ++ A ES L+LA+ GG+ ++ LL+
Sbjct: 389 HKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 447
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA-DSGYTPMDLAVALGYR 213
ER ++ + G TPL+ A R H + V LLA+GA++ + ++ T + LA G+
Sbjct: 448 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 507
Query: 214 KV 215
+V
Sbjct: 508 EV 509
Score = 64.7 bits (156), Expect = 7e-11
Identities = 36/107 (33%), Positives = 60/107 (56%)
Query: 92 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 151
N+ ++ ++ TPL+ AS+ G ++ V+ LL AD + + +AL+ A GG+ DIV
Sbjct: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
Query: 152 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
+LL +I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 358
Score = 64.7 bits (156), Expect = 7e-11
Identities = 48/165 (29%), Positives = 83/165 (50%), Gaps = 7/165 (4%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIE 115
A V+ P S + LT G V ++ + + ++ G+TPL+ A+ G E
Sbjct: 418 AQVNMPADS---FESPLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEE 474
Query: 116 TVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
V LL GA+ + +E +E+AL+LA GG++++ L++ DI + TPL+ A
Sbjct: 475 MVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEA 531
Query: 175 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
+ H++ V+ LLA GA++ +G T + A G+ V V+
Sbjct: 532 SQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
Score = 45.4 bits (106), Expect = 4e-05
Identities = 22/59 (37%), Positives = 36/59 (61%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 161
TPL+ AS G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D++
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 75.9 bits (185), Expect = 3e-14
Identities = 50/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 80 EVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SAL 138
+V+A+ LD VN+ E G + L A + G E + LL A+ + + + L
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 139 SLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
AS+GGY DIV LLL D D+N G T L YA G V V+ LL GA++ +
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 199 SGYTPMDLAVALGYRKVQQVIENH 222
+G+TP+ A + G+ +V +V+ +H
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDH 360
Score = 73.2 bits (178), Expect = 2e-13
Identities = 51/167 (30%), Positives = 80/167 (47%), Gaps = 7/167 (4%)
Query: 49 PVNPEPDASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWA 108
PV P D + H T LT G + + D + D++GFTPLI A
Sbjct: 1040 PVYPSVDIDAHTESN----HDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILA 1095
Query: 109 SAFGEIETVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
+ G + V LL+ G D ++ +++ LSLA +GG ++V LLL R + + +
Sbjct: 1096 ATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD 1155
Query: 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADS--GYTPMDLAVALGY 212
TPL A G +V ++ LL GA++ + S G +P+ LA G+
Sbjct: 1156 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202
Score = 72.4 bits (176), Expect = 3e-13
Identities = 41/121 (33%), Positives = 70/121 (57%), Gaps = 1/121 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL+ AS G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D+
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 221
G TPL+ A R H+ V+ L+++GA++ A++ +T + LA A G+ V +++
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 222 H 222
H
Sbjct: 657 H 657
Score = 68.9 bits (167), Expect = 4e-12
Identities = 53/159 (33%), Positives = 77/159 (48%), Gaps = 4/159 (2%)
Query: 55 DASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEI 114
DA V+S + +T LT G V + L+ + +E G TPL+ A++ G +
Sbjct: 295 DADVNSQSATG---NTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 115 ETVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
E R LL+ GA + + E +ESAL+LA G+ D+V LLE D T L+
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
A HV+ LL GA + ADS +P+ LA G+
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
Score = 67.8 bits (164), Expect = 8e-12
Identities = 43/122 (35%), Positives = 69/122 (56%), Gaps = 2/122 (1%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+K DE T L+ A G +E R LL+ GA ++ A ES L+LA+ GG+ ++ LL+
Sbjct: 400 HKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 458
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA-DSGYTPMDLAVALGYR 213
ER ++ + G TPL+ A R H + V LLA+GA++ + ++ T + LA G+
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518
Query: 214 KV 215
+V
Sbjct: 519 EV 520
Score = 66.6 bits (161), Expect = 2e-11
Identities = 51/171 (29%), Positives = 79/171 (46%), Gaps = 8/171 (4%)
Query: 69 STTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH 128
+T LT + LD V + G TPL+ A++ G E R LL+ GAD +
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 129 I--LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
+ R++AL++A+ G+ LL+ R I++ + G TPL A G H V+ L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 187 LARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE 237
+ GAD+ + TP+ A G+ KV Q + + N P+D E
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV------NQFPSDIE 1389
Score = 64.7 bits (156), Expect = 7e-11
Identities = 36/107 (33%), Positives = 60/107 (56%)
Query: 92 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 151
N+ ++ ++ TPL+ AS+ G ++ V+ LL AD + + +AL+ A GG+ DIV
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 152 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
+LL +I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Score = 57.8 bits (138), Expect = 8e-09
Identities = 43/155 (27%), Positives = 76/155 (49%), Gaps = 5/155 (3%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKP--DERGFTPLIWASAFGEIETVRFLLEWGADP 127
T L+ G V+ + L+ +N + G +PL+ A+ G + V+ LL+ G+D
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
Query: 128 HI-LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
+ + R +AL+LA G ++V LLL+R ++ G TPL+ A G + + L
Sbjct: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
Query: 187 LARGADLTTE--ADSGYTPMDLAVALGYRKVQQVI 219
L +GAD+ S T + +A G+ K +++
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Score = 57.4 bits (137), Expect = 1e-08
Identities = 31/86 (36%), Positives = 52/86 (60%), Gaps = 1/86 (1%)
Query: 135 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 194
++AL+LA GG+ ++V +L+ RD I D G TPL+ A HV VE LL +G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 195 TEAD-SGYTPMDLAVALGYRKVQQVI 219
+++ + TP+ LA + G ++V ++
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLL 1141
Score = 55.8 bits (133), Expect = 3e-08
Identities = 41/120 (34%), Positives = 60/120 (50%), Gaps = 1/120 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
T L A A G E V L+ A K+ + L LA+T G+ +V +LL++ DI
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 163 Y-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 221
+ TPL A G + V+ LLARGA+ S YTP+ LA + GY + +++ N
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Score = 50.8 bits (120), Expect = 1e-06
Identities = 39/133 (29%), Positives = 58/133 (43%), Gaps = 1/133 (0%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIE 115
AS ++ ++ T LT L + E G TPL+ A+ G +
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
Query: 116 TVRFLLEWGADPH-ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
TV+FL+ GA+ + A + +SLA GG+ +V LLL D +G T L+ A
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675
Query: 175 VRGNHVKCVEALL 187
+G H V LL
Sbjct: 676 AKGGHTNVVSYLL 688
Score = 46.6 bits (109), Expect = 2e-05
Identities = 44/181 (24%), Positives = 70/181 (38%), Gaps = 31/181 (17%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L V LD VN P + +PL A+ G +E L+E GA+
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINI--------------------------- 162
+ E + L A+ G+ ++V LLL + +IN
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK 526
Query: 163 ----YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ TPL+ A + H++ V+ LLA GA++ +G T + A G+ V V
Sbjct: 527 AGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
Query: 219 I 219
+
Sbjct: 587 L 587
Score = 36.2 bits (82), Expect = 0.025
Identities = 21/63 (33%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 158 VDINIY-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQ 216
VDI+ + + N T L A G H + V L+AR A + G+TP+ LA G+ V
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
Query: 217 QVI 219
+++
Sbjct: 1105 EIL 1107
Score = 35.8 bits (81), Expect = 0.033
Identities = 30/106 (28%), Positives = 45/106 (42%), Gaps = 6/106 (5%)
Query: 56 ASVSSPQGSSLKHS-----TTLTNRQRGNEVSALPATLDCDNLVNKPDERG-FTPLIWAS 109
A V G+ L+H T L R + + + VN+ T + A
Sbjct: 584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643
Query: 110 AFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLE 155
A G + V LL GADP K+ + L A+ GG+T++V LL+
Sbjct: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 75.9 bits (185), Expect = 3e-14
Identities = 50/144 (34%), Positives = 76/144 (52%), Gaps = 1/144 (0%)
Query: 80 EVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SAL 138
+V+A+ LD VN+ E G + L A + G E + LL A+ + + + L
Sbjct: 217 DVNAVRKLLDEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGNKGDITPL 276
Query: 139 SLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
AS+GGY DIV LLL D D+N G T L YA G V V+ LL GA++ +
Sbjct: 277 MAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVKVLLNEGANIEDHNE 336
Query: 199 SGYTPMDLAVALGYRKVQQVIENH 222
+G+TP+ A + G+ +V +V+ +H
Sbjct: 337 NGHTPLMEAASAGHVEVARVLLDH 360
Score = 73.2 bits (178), Expect = 2e-13
Identities = 51/167 (30%), Positives = 80/167 (47%), Gaps = 7/167 (4%)
Query: 49 PVNPEPDASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWA 108
PV P D + H T LT G + + D + D++GFTPLI A
Sbjct: 1040 PVYPSVDIDAHTESN----HDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILA 1095
Query: 109 SAFGEIETVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
+ G + V LL+ G D ++ +++ LSLA +GG ++V LLL R + + +
Sbjct: 1096 ATAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSD 1155
Query: 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADS--GYTPMDLAVALGY 212
TPL A G +V ++ LL GA++ + S G +P+ LA G+
Sbjct: 1156 YTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202
Score = 72.4 bits (176), Expect = 3e-13
Identities = 41/121 (33%), Positives = 70/121 (57%), Gaps = 1/121 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL+ AS G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D+
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 221
G TPL+ A R H+ V+ L+++GA++ A++ +T + LA A G+ V +++
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 222 H 222
H
Sbjct: 657 H 657
Score = 68.9 bits (167), Expect = 4e-12
Identities = 53/159 (33%), Positives = 77/159 (48%), Gaps = 4/159 (2%)
Query: 55 DASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEI 114
DA V+S + +T LT G V + L+ + +E G TPL+ A++ G +
Sbjct: 295 DADVNSQSATG---NTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHV 351
Query: 115 ETVRFLLEWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 173
E R LL+ GA + + E +ESAL+LA G+ D+V LLE D T L+
Sbjct: 352 EVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALME 411
Query: 174 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
A HV+ LL GA + ADS +P+ LA G+
Sbjct: 412 ACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGH 450
Score = 67.8 bits (164), Expect = 8e-12
Identities = 43/122 (35%), Positives = 69/122 (56%), Gaps = 2/122 (1%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+K DE T L+ A G +E R LL+ GA ++ A ES L+LA+ GG+ ++ LL+
Sbjct: 400 HKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 458
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA-DSGYTPMDLAVALGYR 213
ER ++ + G TPL+ A R H + V LLA+GA++ + ++ T + LA G+
Sbjct: 459 ERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFS 518
Query: 214 KV 215
+V
Sbjct: 519 EV 520
Score = 66.6 bits (161), Expect = 2e-11
Identities = 51/171 (29%), Positives = 79/171 (46%), Gaps = 8/171 (4%)
Query: 69 STTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH 128
+T LT + LD V + G TPL+ A++ G E R LL+ GAD +
Sbjct: 1225 NTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVN 1284
Query: 129 I--LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
+ R++AL++A+ G+ LL+ R I++ + G TPL A G H V+ L
Sbjct: 1285 APPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Query: 187 LARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE 237
+ GAD+ + TP+ A G+ KV Q + + N P+D E
Sbjct: 1345 VQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV------NQFPSDIE 1389
Score = 64.7 bits (156), Expect = 7e-11
Identities = 36/107 (33%), Positives = 60/107 (56%)
Query: 92 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 151
N+ ++ ++ TPL+ AS+ G ++ V+ LL AD + + +AL+ A GG+ DIV
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 152 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
+LL +I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Score = 57.8 bits (138), Expect = 8e-09
Identities = 43/155 (27%), Positives = 76/155 (49%), Gaps = 5/155 (3%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKP--DERGFTPLIWASAFGEIETVRFLLEWGADP 127
T L+ G V+ + L+ +N + G +PL+ A+ G + V+ LL+ G+D
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDI 1216
Query: 128 HI-LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
+ + R +AL+LA G ++V LLL+R ++ G TPL+ A G + + L
Sbjct: 1217 NAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1276
Query: 187 LARGADLTTE--ADSGYTPMDLAVALGYRKVQQVI 219
L +GAD+ S T + +A G+ K +++
Sbjct: 1277 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1311
Score = 57.4 bits (137), Expect = 1e-08
Identities = 31/86 (36%), Positives = 52/86 (60%), Gaps = 1/86 (1%)
Query: 135 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 194
++AL+LA GG+ ++V +L+ RD I D G TPL+ A HV VE LL +G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 195 TEAD-SGYTPMDLAVALGYRKVQQVI 219
+++ + TP+ LA + G ++V ++
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLL 1141
Score = 55.8 bits (133), Expect = 3e-08
Identities = 41/120 (34%), Positives = 60/120 (50%), Gaps = 1/120 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
T L A A G E V L+ A K+ + L LA+T G+ +V +LL++ DI
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 163 Y-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 221
+ TPL A G + V+ LLARGA+ S YTP+ LA + GY + +++ N
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Score = 50.8 bits (120), Expect = 1e-06
Identities = 39/133 (29%), Positives = 58/133 (43%), Gaps = 1/133 (0%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIE 115
AS ++ ++ T LT L + E G TPL+ A+ G +
Sbjct: 556 ASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHLC 615
Query: 116 TVRFLLEWGADPH-ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
TV+FL+ GA+ + A + +SLA GG+ +V LLL D +G T L+ A
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675
Query: 175 VRGNHVKCVEALL 187
+G H V LL
Sbjct: 676 AKGGHTNVVSYLL 688
Score = 46.6 bits (109), Expect = 2e-05
Identities = 44/181 (24%), Positives = 70/181 (38%), Gaps = 31/181 (17%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L V LD VN P + +PL A+ G +E L+E GA+
Sbjct: 407 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGANLEE 466
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINI--------------------------- 162
+ E + L A+ G+ ++V LLL + +IN
Sbjct: 467 VNDEGYTPLMEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIK 526
Query: 163 ----YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ TPL+ A + H++ V+ LLA GA++ +G T + A G+ V V
Sbjct: 527 AGADIELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADV 586
Query: 219 I 219
+
Sbjct: 587 L 587
Score = 36.2 bits (82), Expect = 0.025
Identities = 21/63 (33%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 158 VDINIY-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQ 216
VDI+ + + N T L A G H + V L+AR A + G+TP+ LA G+ V
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
Query: 217 QVI 219
+++
Sbjct: 1105 EIL 1107
Score = 35.8 bits (81), Expect = 0.033
Identities = 30/106 (28%), Positives = 45/106 (42%), Gaps = 6/106 (5%)
Query: 56 ASVSSPQGSSLKHS-----TTLTNRQRGNEVSALPATLDCDNLVNKPDERG-FTPLIWAS 109
A V G+ L+H T L R + + + VN+ T + A
Sbjct: 584 ADVLLQAGADLEHESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLAC 643
Query: 110 AFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLE 155
A G + V LL GADP K+ + L A+ GG+T++V LL+
Sbjct: 644 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 75.9 bits (185), Expect = 3e-14
Identities = 64/247 (25%), Positives = 107/247 (43%), Gaps = 36/247 (14%)
Query: 2 ELTQPAEDLIQTQQTPASELG---DPEDPGEEAADGSDTVVL------------------ 40
+LT P+ DL + + P L P++P + A+ + T+ +
Sbjct: 733 QLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTH 792
Query: 41 SLFPCTPEPVNPEPDASVSSPQ------------GSSLKHSTTLTNRQRGNEVSALPATL 88
S+ +P P P +S + H T LT G + L
Sbjct: 793 SIAASISQPQTPTPSPIISPSAMLPIYPAIDIDAQTESNHDTALTLACAGGHEELVQTLL 852
Query: 89 DCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE-RESALSLASTGGYT 147
+ + D++GFTPLI A+ G + V LL+ GAD ++ +++ LSLA +GG
Sbjct: 853 ERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQ 912
Query: 148 DIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADS--GYTPMD 205
++V LLL R + + + TPL A G +V ++ LL GA++ + S G +P+
Sbjct: 913 EVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLM 972
Query: 206 LAVALGY 212
LA G+
Sbjct: 973 LAAMNGH 979
Score = 74.7 bits (182), Expect = 6e-14
Identities = 42/121 (34%), Positives = 71/121 (58%), Gaps = 1/121 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL+ A+ G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 221
G TPL+ A R HV V+ L+++GA++ T A++ +T + LA A G+ V +++
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 222 H 222
H
Sbjct: 686 H 686
Score = 68.6 bits (166), Expect = 5e-12
Identities = 49/145 (33%), Positives = 70/145 (48%), Gaps = 1/145 (0%)
Query: 69 STTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH 128
+T LT G V + L+ + +E G TPL+ A + G +E R LLE GA +
Sbjct: 335 NTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGIN 394
Query: 129 ILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 187
+ E +ESAL+LA G+ ++V LLE D T L+ A HV+ LL
Sbjct: 395 THSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLL 454
Query: 188 ARGADLTTEADSGYTPMDLAVALGY 212
GA + ADS +P+ LA G+
Sbjct: 455 DSGAQVNMPADSFESPLTLAACGGH 479
Score = 67.4 bits (163), Expect = 1e-11
Identities = 53/169 (31%), Positives = 82/169 (48%), Gaps = 10/169 (5%)
Query: 71 TLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI- 129
TL Q EV +L LD V + G TPL+ A++ G E R LL+ GAD +
Sbjct: 1006 TLACFQGRTEVVSL--LLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAP 1063
Query: 130 -LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLA 188
+ R++AL++A+ G+ LL+ R I++ + G TPL A G H+ V+ L+
Sbjct: 1064 PVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLLVQ 1123
Query: 189 RGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE 237
GAD+ + TP+ A G+ KV + + + N P+D E
Sbjct: 1124 AGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEV------NQFPSDSE 1166
Score = 65.5 bits (158), Expect = 4e-11
Identities = 38/104 (36%), Positives = 54/104 (51%)
Query: 112 GEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPL 171
G +E VRFLLE GAD E +AL A G+ ++ LLL+ +N+ + +PL
Sbjct: 412 GHLEMVRFLLEAGADQEHKTDEMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPL 471
Query: 172 LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
A G HV+ L+ RGA L D GYTP+ A G+ ++
Sbjct: 472 TLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEM 515
Score = 65.5 bits (158), Expect = 4e-11
Identities = 42/122 (34%), Positives = 67/122 (54%), Gaps = 2/122 (1%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+K DE T L+ A G +E R LL+ GA ++ A ES L+LA+ GG+ ++ LL+
Sbjct: 429 HKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLI 487
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA-DSGYTPMDLAVALGYR 213
ER + + G TPL+ A R H + V LL +GA++ + ++ T + LA G+
Sbjct: 488 ERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFL 547
Query: 214 KV 215
+V
Sbjct: 548 EV 549
Score = 63.9 bits (154), Expect = 1e-10
Identities = 36/107 (33%), Positives = 58/107 (54%)
Query: 92 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 151
N+ ++ + TPL+ A+ G ++ V+ LL AD + + +AL+ A GGY D+V
Sbjct: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
Query: 152 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
+LLE I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 352 VLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Score = 61.6 bits (148), Expect = 6e-10
Identities = 40/113 (35%), Positives = 60/113 (53%), Gaps = 1/113 (0%)
Query: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
A + G++ VR LL G + +E ES L LA + GY ++ +LL ++ G
Sbjct: 241 ACSEGDVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKG 300
Query: 168 G-TPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
TPL+ A G HVK V+ LLA AD+ ++ +G T + A A GY V +V+
Sbjct: 301 DITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVL 353
Score = 60.1 bits (144), Expect = 2e-09
Identities = 43/141 (30%), Positives = 70/141 (49%), Gaps = 1/141 (0%)
Query: 80 EVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-SAL 138
+V+A+ L VN+ E G + L A + G E + LL A+ + + + L
Sbjct: 246 DVNAVRKLLIEGRSVNEHTEEGESLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPL 305
Query: 139 SLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 198
A+ GG+ IV LLL D+N G T L YA G +V V+ LL GA + +
Sbjct: 306 MAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNE 365
Query: 199 SGYTPMDLAVALGYRKVQQVI 219
+G+TP+ A + G+ +V +++
Sbjct: 366 NGHTPLMEAGSAGHVEVARLL 386
Score = 58.2 bits (139), Expect = 6e-09
Identities = 33/86 (38%), Positives = 52/86 (60%), Gaps = 1/86 (1%)
Query: 135 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 194
++AL+LA GG+ ++V LLER I D G TPL+ A HV VE LL GAD+
Sbjct: 833 DTALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIE 892
Query: 195 TEAD-SGYTPMDLAVALGYRKVQQVI 219
+++ + TP+ LA + G ++V +++
Sbjct: 893 AQSERTKDTPLSLACSGGRQEVVELL 918
Score = 58.2 bits (139), Expect = 6e-09
Identities = 44/155 (28%), Positives = 76/155 (49%), Gaps = 5/155 (3%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKP--DERGFTPLIWASAFGEIETVRFLLEWGADP 127
T L+ G V+ + L+ +N + G +PL+ A+ G V+ LL+ G+D
Sbjct: 934 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHTAAVKLLLDMGSDI 993
Query: 128 HI-LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
+ + R +AL+LA G T++V LLL+R ++ G TPL+ A G + + L
Sbjct: 994 NAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVL 1053
Query: 187 LARGADLTTE--ADSGYTPMDLAVALGYRKVQQVI 219
L +GAD+ S T + +A G+ K +++
Sbjct: 1054 LDKGADVNAPPVPSSRDTALTIAADKGHYKFCELL 1088
Score = 49.7 bits (117), Expect = 2e-06
Identities = 38/119 (31%), Positives = 52/119 (43%), Gaps = 1/119 (0%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH- 128
T LT L + E G TPL+ A+ G + TV+FL+ GA+ +
Sbjct: 599 TALTYACENGHTDVADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNR 658
Query: 129 ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 187
A + LSLA GG+ +V LLL D +G T L+ A +G H V LL
Sbjct: 659 TTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLL 717
Score = 48.9 bits (115), Expect = 4e-06
Identities = 42/151 (27%), Positives = 65/151 (43%), Gaps = 1/151 (0%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L G V + L VN G T L +A A G ++ V+ LLE GA
Sbjct: 303 TPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVKVLLESGASIED 362
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWN-GGTPLLYAVRGNHVKCVEALLA 188
+ + L A + G+ ++ LLLE IN + + L A H++ V LL
Sbjct: 363 HNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLE 422
Query: 189 RGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
GAD + D +T + A G+ +V +++
Sbjct: 423 AGADQEHKTDEMHTALMEACMDGHVEVARLL 453
Score = 46.6 bits (109), Expect = 2e-05
Identities = 44/181 (24%), Positives = 69/181 (38%), Gaps = 31/181 (17%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L V LD VN P + +PL A+ G +E L+E GA
Sbjct: 436 TALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGASLEE 495
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINI--------------------------- 162
+ E + L A+ G+ ++V LLL + +IN
Sbjct: 496 VNDEGYTPLMEAAREGHEEMVALLLGQGANINAQTEETQETALTLACCGGFLEVADFLIK 555
Query: 163 ----YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ TPL+ A + H++ V+ LLA GA++ +G T + A G+ V V
Sbjct: 556 AGADIELGCSTPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADV 615
Query: 219 I 219
+
Sbjct: 616 L 616
Score = 36.6 bits (83), Expect = 0.019
Identities = 32/106 (30%), Positives = 44/106 (41%), Gaps = 6/106 (5%)
Query: 56 ASVSSPQGSSLKHS-----TTLTNRQRGNEVSALPATLDCDNLVNKPDERG-FTPLIWAS 109
A V G+ L+H T L R V + + VN+ T L A
Sbjct: 613 ADVLLQAGADLEHESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLAC 672
Query: 110 AFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLE 155
A G + V LL GADP K+ + L A+ GG+T +V LL+
Sbjct: 673 AGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 75.5 bits (184), Expect = 4e-14
Identities = 40/114 (35%), Positives = 62/114 (54%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN D+ G+TP+IWA+ + ++ V+ LL G+D +I E L A+ G DI +L
Sbjct: 866 VNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEIL 925
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
L D++ + +G +PL A R N CV L+R +D+T + G TP+ A
Sbjct: 926 LAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979
Score = 55.1 bits (131), Expect = 5e-08
Identities = 39/131 (29%), Positives = 67/131 (51%), Gaps = 5/131 (3%)
Query: 96 KPDERGFTP--LIWASAFGEIETVRFLLEWGADPHILAKE--RESALSLASTGGYTDIVG 151
KP + F P L +++ GE++ V +L G DP+ + + S L A+ G+ DI
Sbjct: 731 KPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICH 790
Query: 152 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 211
+L++ +I+ + TPL+ A NH++ V+ L+ GA + + G T + LA G
Sbjct: 791 MLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKG 850
Query: 212 -YRKVQQVIEN 221
Y VQ ++ N
Sbjct: 851 HYEVVQYLLSN 861
Score = 54.7 bits (130), Expect = 7e-08
Identities = 31/92 (33%), Positives = 53/92 (57%), Gaps = 1/92 (1%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLER-DVDIN 161
TPL+ A+ +E V++L++ GA E + L LA+ G+ ++V LL +D+N
Sbjct: 808 TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVN 867
Query: 162 IYDWNGGTPLLYAVRGNHVKCVEALLARGADL 193
D G TP+++A HV V+ LL++G+D+
Sbjct: 868 CQDDGGWTPMIWATEYKHVDLVKLLLSKGSDI 899
Score = 44.3 bits (103), Expect = 9e-05
Identities = 27/103 (26%), Positives = 53/103 (51%), Gaps = 1/103 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
+PL A+ G ++ L++ GA+ ++++ + L A+ + + V L++ ++
Sbjct: 775 SPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDP 834
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARG-ADLTTEADSGYTPM 204
D G T L A + H + V+ LL+ G D+ + D G+TPM
Sbjct: 835 KDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPM 877
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 74.7 bits (182), Expect = 6e-14
Identities = 39/128 (30%), Positives = 73/128 (57%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
+ G+TPL A+ +++ LLE+GAD + + ++ +++ LA+ G+ D+V LLL R+
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
++N+ + +G TPL A + + V E L+ +GA + + GYTP+ + G K+
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
Query: 219 IENHILKL 226
+ H K+
Sbjct: 749 LLQHSAKV 756
Score = 70.5 bits (171), Expect = 1e-12
Identities = 39/126 (30%), Positives = 68/126 (53%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L AS G +E V LL+ A+ K+ +AL +AS G ++V +L
Sbjct: 67 INICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVL 126
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ ++N NG TPL A + NH++ V+ LL GA + + G+TP+ +A+ G+
Sbjct: 127 VTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHD 186
Query: 214 KVQQVI 219
+V ++
Sbjct: 187 QVVSLL 192
Score = 66.6 bits (161), Expect = 2e-11
Identities = 44/146 (30%), Positives = 69/146 (47%)
Query: 77 RGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 136
R ++ A L DN + + GFTPL A+ +G I LL A A+ +
Sbjct: 211 RKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT 270
Query: 137 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 196
L +AS G ++V LLL+R I+ +G TPL R H + VE LL R A + ++
Sbjct: 271 PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSK 330
Query: 197 ADSGYTPMDLAVALGYRKVQQVIENH 222
+G +P+ +A + Q++ H
Sbjct: 331 TKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 65.1 bits (157), Expect = 5e-11
Identities = 42/164 (25%), Positives = 71/164 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P +L T L + N + + L + E G TP+ A+ G + V
Sbjct: 391 ANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS 450
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
L+ GA P+ E+AL +A+ G ++V L++ + + TPL + R
Sbjct: 451 QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLG 510
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
V+ LL +GA SGYTP+ L+ G+ V + +H
Sbjct: 511 KADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDH 554
Score = 64.7 bits (156), Expect = 7e-11
Identities = 40/125 (32%), Positives = 63/125 (50%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
N + RG T L A+ G+ E VR+L++ GA AK+ ++ L +++ G DIV LL
Sbjct: 460 NTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL 519
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 214
++ N +G TPL + R H LL GA L+ G+TP+ +A G +
Sbjct: 520 QQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLE 579
Query: 215 VQQVI 219
V ++
Sbjct: 580 VANLL 584
Score = 62.0 bits (149), Expect = 4e-10
Identities = 48/175 (27%), Positives = 82/175 (46%), Gaps = 11/175 (6%)
Query: 48 EPVNPEPDASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIW 107
E + E + ++ +G++ H +L + EV + T + VN + GFTPL
Sbjct: 92 ELLQREANVDAATKKGNTALHIASLAGQA---EVVKVLVTNGAN--VNAQSQNGFTPLYM 146
Query: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
A+ +E V+FLL+ GA + ++ + L++A G+ +V LLLE D +
Sbjct: 147 AAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV----- 201
Query: 168 GTPLLY-AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 221
P L+ A R + K LL + E+ SG+TP+ +A G V ++ N
Sbjct: 202 RLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Score = 60.1 bits (144), Expect = 2e-09
Identities = 40/121 (33%), Positives = 54/121 (44%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G TPL A+ + + LL+ GA PH AK + L +A+ DI LLE D
Sbjct: 598 GLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADA 657
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
N G + A + HV V LL R A++ SG TP+ LA V +V+
Sbjct: 658 NAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLV 717
Query: 221 N 221
N
Sbjct: 718 N 718
Score = 59.7 bits (143), Expect = 2e-09
Identities = 34/124 (27%), Positives = 63/124 (50%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
+ G +PL A+ + V+ LL+ + + +AL +A+ G+ + +LL++
Sbjct: 332 KNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKA 391
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ N NG TPL A + N +K +E LL GA + +SG TP+ +A +G+ +
Sbjct: 392 NPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQ 451
Query: 219 IENH 222
+ +H
Sbjct: 452 LMHH 455
Score = 55.8 bits (133), Expect = 3e-08
Identities = 38/157 (24%), Positives = 69/157 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP ++++ T L R + + + V + TPL ++ G+ + V+
Sbjct: 457 ASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQ 516
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P+ + L L++ G+ D+ LL+ ++I G TPL A +
Sbjct: 517 QLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYG 576
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
++ LL + A SG TP+ +A +KV
Sbjct: 577 KLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKV 613
Score = 55.5 bits (132), Expect = 4e-08
Identities = 35/117 (29%), Positives = 57/117 (48%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL AS G V+ LL+ GA ++ + L + G+ +V +LL+R I
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
NG +PL A +G+H+ CV+ LL + + T + +A G+ KV +V+
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Score = 54.7 bits (130), Expect = 7e-08
Identities = 35/113 (30%), Positives = 56/113 (49%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
N G+TPL ++ G + FLL+ GA I K+ + L +A+ G ++ LLL
Sbjct: 526 NAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLL 585
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
++ + +G TPL A ++ K LL +GA A +GYTP+ +A
Sbjct: 586 QKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Score = 52.4 bits (124), Expect = 3e-07
Identities = 44/161 (27%), Positives = 74/161 (45%), Gaps = 4/161 (2%)
Query: 76 QRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE 135
+RGN + + LD ++ G TPL + G + V LL+ A K
Sbjct: 277 KRGN-ANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGL 335
Query: 136 SALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
S L +A+ G + + V LLL+ +V ++ + T L A H K + LL + A+
Sbjct: 336 SPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNA 395
Query: 196 EADSGYTPMDLAVALGYRKVQQVIENH---ILKLFQSNLVP 233
+A +G+TP+ +A KV +++ H I + +S L P
Sbjct: 396 KALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTP 436
Score = 52.0 bits (123), Expect = 4e-07
Identities = 29/108 (26%), Positives = 57/108 (52%)
Query: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
A+ G +E ++ G D +I + +AL LAS G+ ++V LL+R+ +++ G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
T L A + V+ L+ GA++ ++ +G+TP+ +A + +V
Sbjct: 108 NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEV 155
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/93 (31%), Positives = 46/93 (49%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
V+ + G+TPL +G I+ V FLL+ A + K + L A+ G+T I+ +L
Sbjct: 723 VDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVL 782
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
L+ + N NG T L A R ++ V+ L
Sbjct: 783 LQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 39.3 bits (90), Expect = 0.003
Identities = 31/113 (27%), Positives = 48/113 (42%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
T L A+ G + + LL+ A+P+ A + L +A ++ LLL+ I
Sbjct: 369 TALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+G TP+ A HV V L+ GA T G T + +A G +V
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 481
Score = 37.7 bits (86), Expect = 0.009
Identities = 24/79 (30%), Positives = 39/79 (49%)
Query: 141 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 200
A+ G+ + ++ VDINI + NG L A + HV+ V LL R A++ G
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG 107
Query: 201 YTPMDLAVALGYRKVQQVI 219
T + +A G +V +V+
Sbjct: 108 NTALHIASLAGQAEVVKVL 126
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 73.2 bits (178), Expect = 2e-13
Identities = 46/127 (36%), Positives = 71/127 (55%), Gaps = 5/127 (3%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA-----STGGYTD 148
VNK D G T LI A+ G E V LL+ GA+ + + +ALS+A ++ G+
Sbjct: 670 VNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHAS 729
Query: 149 IVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAV 208
+V LL++R +++ D +G TPLL A HV V+ LL GAD+ ++G TP+ A
Sbjct: 730 VVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAA 789
Query: 209 ALGYRKV 215
++G+ V
Sbjct: 790 SMGHASV 796
Score = 68.9 bits (167), Expect = 4e-12
Identities = 60/198 (30%), Positives = 85/198 (42%), Gaps = 7/198 (3%)
Query: 30 EAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQGSSLKHS-----TTLTNRQRGNEVSAL 84
E DG + ++ C P S+ +G+ + H T L V +
Sbjct: 706 EDVDGRTALSVAAL-CVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVV 764
Query: 85 PATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTG 144
L+ V+ D G TPL+ A++ G V LL WGA + E + LS+AS
Sbjct: 765 DLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQ 824
Query: 145 GYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPM 204
G ++V LL+R +D N D G TPL A H EAL+ +GA + G P
Sbjct: 825 GNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDGRIPF 884
Query: 205 DLAVALG-YRKVQQVIEN 221
LA G Y VQ ++EN
Sbjct: 885 ILASQEGHYDCVQILLEN 902
Score = 61.6 bits (148), Expect = 6e-10
Identities = 44/138 (31%), Positives = 63/138 (45%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T LT R + + C +N D+ G+T L A+ G E V LL G
Sbjct: 580 TPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDC 639
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+ +AL A+ GG+ DIV LL+ ++N D G T L+ A H + VE LL
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Query: 190 GADLTTEADSGYTPMDLA 207
GA++ E G T + +A
Sbjct: 700 GAEVNHEDVDGRTALSVA 717
Score = 60.8 bits (146), Expect = 1e-09
Identities = 40/122 (32%), Positives = 60/122 (49%), Gaps = 2/122 (1%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN D+R T I A +++R LL+ GA + + L+ A+ G D+V LL
Sbjct: 507 VNSEDDR--TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLL 564
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ R D+ I D +G TPL A R H K V L+ GA++ G+T + A G+
Sbjct: 565 VSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHT 624
Query: 214 KV 215
+V
Sbjct: 625 EV 626
Score = 60.1 bits (144), Expect = 2e-09
Identities = 38/125 (30%), Positives = 64/125 (51%)
Query: 98 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 157
D G TPL A+ G + V L+ GA+ + ++ +AL A+ GG+T++V LL
Sbjct: 575 DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAG 634
Query: 158 VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 217
V ++ D + T L A G H V LL GA++ + G T + A +G+R++ +
Sbjct: 635 VKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVE 694
Query: 218 VIENH 222
+ +H
Sbjct: 695 HLLDH 699
Score = 57.8 bits (138), Expect = 8e-09
Identities = 38/129 (29%), Positives = 62/129 (48%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
V D G T L + G +E V+ L+ + AD + E+ SAL A+ G+ +V LL
Sbjct: 972 VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLL 1031
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+E ++ G T L A + H+ V+ LL GAD G T M +A G+
Sbjct: 1032 IEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHS 1091
Query: 214 KVQQVIENH 222
++ +++E +
Sbjct: 1092 QIIKLLEKY 1100
Score = 56.6 bits (135), Expect = 2e-08
Identities = 43/131 (32%), Positives = 62/131 (47%), Gaps = 1/131 (0%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T+ RQ ++ LD VN+ D G T L A+ G ++ V L+ GAD I
Sbjct: 514 TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEI 573
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+ L+LA+ G+T +V L+ +IN D +G T L A G H + V ALL
Sbjct: 574 EDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYA 633
Query: 190 GADL-TTEADS 199
G + +ADS
Sbjct: 634 GVKVDCADADS 644
Score = 55.8 bits (133), Expect = 3e-08
Identities = 37/129 (28%), Positives = 62/129 (48%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
V+ D G T L ASA G +E VR LL+ G D + + L +A+ G+ I L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+E+ N D +G P + A + H CV+ LL +++ G + +A G+R
Sbjct: 867 IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
Query: 214 KVQQVIENH 222
+ +++ +H
Sbjct: 927 DIVELLFSH 935
Score = 52.8 bits (125), Expect = 3e-07
Identities = 36/125 (28%), Positives = 58/125 (46%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
N+ D G P I AS G + V+ LLE ++ + +AL +A+ G+ DIV LL
Sbjct: 874 NEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLF 933
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 214
D+N D +G L N + E L GA++ G T + ++ G+ +
Sbjct: 934 SHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHME 993
Query: 215 VQQVI 219
+ QV+
Sbjct: 994 MVQVL 998
Score = 49.7 bits (117), Expect = 2e-06
Identities = 46/176 (26%), Positives = 68/176 (38%), Gaps = 26/176 (14%)
Query: 66 LKHSTT--LTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 123
+KH T L N G+ + A+ T NL + LI ++ E + + W
Sbjct: 418 VKHCTQKYLCNAAEGHRMLAMSYTCQAKNLTPLEAQEFALHLINSNLQLETAELALWMIW 477
Query: 124 GADP------HILAKERESALSLASTGGYT------------------DIVGLLLERDVD 159
P ++ KE+E L G + D + LL+
Sbjct: 478 NGTPVRDSLSTLIPKEQEVLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGAS 537
Query: 160 INIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+N D NG T L A + V L++RGADL E G+TP+ LA G+ KV
Sbjct: 538 VNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKV 593
Score = 48.9 bits (115), Expect = 4e-06
Identities = 44/153 (28%), Positives = 65/153 (42%), Gaps = 1/153 (0%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L+ V + LD N D+ G+TPL A+ G L+E GA +
Sbjct: 816 TVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNE 875
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+ + LAS G+ D V +LLE +I+ ++G L A H VE L +
Sbjct: 876 IDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSH 935
Query: 190 GADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 221
GAD+ +AD T LA+ + +EN
Sbjct: 936 GADVNCKDADGRPTLYILALENQLTMAEYFLEN 968
Score = 48.1 bits (113), Expect = 6e-06
Identities = 35/129 (27%), Positives = 58/129 (44%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN D G L + ++ + LE GA+ E +AL ++ G+ ++V +L
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ D+N D + L A HVK V+ L+ GA + + G T + +A G+
Sbjct: 999 IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
Query: 214 KVQQVIENH 222
V QV+ H
Sbjct: 1059 DVVQVLLEH 1067
Score = 45.8 bits (107), Expect = 3e-05
Identities = 30/98 (30%), Positives = 48/98 (48%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN D + L A+ G ++ V+ L+E GA + +AL +A+ G+ D+V +L
Sbjct: 1005 VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGA 191
LE D N D G T + A + H + ++ L GA
Sbjct: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
Score = 37.4 bits (85), Expect = 0.011
Identities = 21/61 (34%), Positives = 36/61 (59%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+V+ +G T L A+ G I+ V+ LLE GADP+ + +A+ +A+ G++ I+ L
Sbjct: 1037 VVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKL 1096
Query: 153 L 153
L
Sbjct: 1097 L 1097
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 72.8 bits (177), Expect = 2e-13
Identities = 44/115 (38%), Positives = 62/115 (53%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+VN+ E GFTPL A+ +G + LL GA A+ + L +AS G T++V L
Sbjct: 204 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 263
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
LL+R I+ +G TPL A R H + VE LL RGA L +G +P+ +A
Sbjct: 264 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 318
Score = 71.2 bits (173), Expect = 7e-13
Identities = 38/126 (30%), Positives = 68/126 (53%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L A+ G + V+ LL G+ K+ +AL +AS G ++V +L
Sbjct: 36 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 95
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
++ +IN NG TPL A + NH+ V+ LL GA+ +T + G+TP+ +A+ G+
Sbjct: 96 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 155
Query: 214 KVQQVI 219
+ ++
Sbjct: 156 QAVAIL 161
Score = 70.9 bits (172), Expect = 9e-13
Identities = 46/164 (28%), Positives = 79/164 (48%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP ++ T L + N++ L+ N ++G TPL AS G + V
Sbjct: 599 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 658
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA+ H+ K ++L LA+ ++ +L + D + + G TPL+ A
Sbjct: 659 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYG 718
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
+VK V LL +GA++ + +GYTP+ A G+ + V+ H
Sbjct: 719 NVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 762
Score = 62.4 bits (150), Expect = 3e-10
Identities = 42/120 (35%), Positives = 60/120 (50%)
Query: 100 RGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVD 159
RG T L A+ G++E VR LL GA A+E ++ L +AS G T+IV LLL+
Sbjct: 442 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 501
Query: 160 INIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
+ NG TPL + R V LL GA + G+TP+ +A G V +++
Sbjct: 502 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Score = 59.7 bits (143), Expect = 2e-09
Identities = 39/124 (31%), Positives = 54/124 (43%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
+ G TPL A+ + + LLE GA PH AK + L +A+ I LL
Sbjct: 573 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 632
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ NI G TPL A + H V LL +GA++ SG T + LA V +
Sbjct: 633 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 692
Query: 219 IENH 222
+ H
Sbjct: 693 LTKH 696
Score = 59.3 bits (142), Expect = 3e-09
Identities = 37/122 (30%), Positives = 61/122 (50%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G+TPL ++ G+++ LLE GA + K+ + L +A+ G D+ LLL+R
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ NG TPL A ++ K LL +GA A +GYTP+ +A ++ +
Sbjct: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
Query: 221 NH 222
N+
Sbjct: 629 NY 630
Score = 58.9 bits (141), Expect = 4e-09
Identities = 40/135 (29%), Positives = 68/135 (50%), Gaps = 7/135 (5%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
+ G +PL A+ +E V+ LL+ A + + +AL +A+ G+ + LLL++
Sbjct: 309 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 368
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ N NG TPL A + N +K +E L+ GA + +SG TP+ +A +G+
Sbjct: 369 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL----- 423
Query: 219 IENHILKLFQSNLVP 233
N +L L Q+ P
Sbjct: 424 --NIVLLLLQNGASP 436
Score = 58.2 bits (139), Expect = 6e-09
Identities = 36/123 (29%), Positives = 62/123 (50%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
GFTPL A I+ + L+++GA + + + + +A+ G+ +IV LLL+
Sbjct: 377 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 436
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
++ + G T L A R V+ V LL GA + A TP+ +A LG ++ Q++
Sbjct: 437 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 496
Query: 221 NHI 223
H+
Sbjct: 497 QHM 499
Score = 57.4 bits (137), Expect = 1e-08
Identities = 37/119 (31%), Positives = 59/119 (49%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G TPL AS G V+ LL+ G ++ + L A+ G+ +V LLLER +
Sbjct: 245 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 304
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
NG +PL A +G+HV+CV+ LL A + T + +A G+ +V +++
Sbjct: 305 LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 363
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/161 (25%), Positives = 68/161 (42%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P +L T L + N + + + + E G TP+ A+ G + V
Sbjct: 368 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 427
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P + E+AL +A+ G ++V LL ++ TPL A R
Sbjct: 428 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 487
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
+ V+ LL A +GYTP+ ++ G V V+
Sbjct: 488 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 528
Score = 56.2 bits (134), Expect = 2e-08
Identities = 42/157 (26%), Positives = 69/157 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP ++++ T L R +V + L LV+ TPL AS G+ E V+
Sbjct: 434 ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQ 493
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ A P + L +++ G D+ +LLE ++ G TPL A +
Sbjct: 494 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 553
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+ + LL R A + +G TP+ +A +KV
Sbjct: 554 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 590
Score = 55.1 bits (131), Expect = 5e-08
Identities = 32/95 (33%), Positives = 50/95 (52%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G+TPLI A +G ++ V FLL+ GA+ + K + L A+ G+T I+ +LL+
Sbjct: 707 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 766
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
N NG T L A R ++ V+ L ++TT
Sbjct: 767 NATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 801
Score = 51.2 bits (121), Expect = 8e-07
Identities = 44/172 (25%), Positives = 76/172 (44%), Gaps = 14/172 (8%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
SS ++ K +T L + + + +N + GFTPL A+ I+ V+
Sbjct: 67 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 126
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY-AVRG 177
+LLE GA+ ++ + L++A G+ V +LLE D + P L+ A R
Sbjct: 127 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV-----RLPALHIAARK 181
Query: 178 NHVKCVEALLA--RGADLTTE------ADSGYTPMDLAVALGYRKVQQVIEN 221
+ K LL AD+ ++ +SG+TP+ +A G V ++ N
Sbjct: 182 DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Score = 43.5 bits (101), Expect = 2e-04
Identities = 31/116 (26%), Positives = 54/116 (46%), Gaps = 10/116 (8%)
Query: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
A+ G ++ V L+ G D + + +AL LA+ G+ +V LL R ++ G
Sbjct: 17 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 76
Query: 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 223
T L A + V+ L+ GA++ ++ +G+TP+ +A ENHI
Sbjct: 77 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ----------ENHI 122
Score = 42.0 bits (97), Expect = 5e-04
Identities = 24/82 (29%), Positives = 41/82 (50%)
Query: 138 LSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA 197
L +A+ G ++ LLL R ++ NG TPL A + + V+ LL RG + +
Sbjct: 216 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 275
Query: 198 DSGYTPMDLAVALGYRKVQQVI 219
G TP+ A G+ +V +++
Sbjct: 276 RDGLTPLHCAARSGHDQVVELL 297
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 72.8 bits (177), Expect = 2e-13
Identities = 44/115 (38%), Positives = 62/115 (53%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+VN+ E GFTPL A+ +G + LL GA A+ + L +AS G T++V L
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
LL+R I+ +G TPL A R H + VE LL RGA L +G +P+ +A
Sbjct: 285 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 71.2 bits (173), Expect = 7e-13
Identities = 38/126 (30%), Positives = 68/126 (53%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L A+ G + V+ LL G+ K+ +AL +AS G ++V +L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
++ +IN NG TPL A + NH+ V+ LL GA+ +T + G+TP+ +A+ G+
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 214 KVQQVI 219
+ ++
Sbjct: 177 QAVAIL 182
Score = 70.9 bits (172), Expect = 9e-13
Identities = 46/164 (28%), Positives = 79/164 (48%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP ++ T L + N++ L+ N ++G TPL AS G + V
Sbjct: 620 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 679
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA+ H+ K ++L LA+ ++ +L + D + + G TPL+ A
Sbjct: 680 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYG 739
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
+VK V LL +GA++ + +GYTP+ A G+ + V+ H
Sbjct: 740 NVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 62.4 bits (150), Expect = 3e-10
Identities = 42/120 (35%), Positives = 60/120 (50%)
Query: 100 RGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVD 159
RG T L A+ G++E VR LL GA A+E ++ L +AS G T+IV LLL+
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 160 INIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
+ NG TPL + R V LL GA + G+TP+ +A G V +++
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 59.7 bits (143), Expect = 2e-09
Identities = 39/124 (31%), Positives = 54/124 (43%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
+ G TPL A+ + + LLE GA PH AK + L +A+ I LL
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ NI G TPL A + H V LL +GA++ SG T + LA V +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 219 IENH 222
+ H
Sbjct: 714 LTKH 717
Score = 59.3 bits (142), Expect = 3e-09
Identities = 37/122 (30%), Positives = 61/122 (50%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G+TPL ++ G+++ LLE GA + K+ + L +A+ G D+ LLL+R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ NG TPL A ++ K LL +GA A +GYTP+ +A ++ +
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 221 NH 222
N+
Sbjct: 650 NY 651
Score = 58.9 bits (141), Expect = 4e-09
Identities = 40/135 (29%), Positives = 68/135 (50%), Gaps = 7/135 (5%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
+ G +PL A+ +E V+ LL+ A + + +AL +A+ G+ + LLL++
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ N NG TPL A + N +K +E L+ GA + +SG TP+ +A +G+
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL----- 444
Query: 219 IENHILKLFQSNLVP 233
N +L L Q+ P
Sbjct: 445 --NIVLLLLQNGASP 457
Score = 58.2 bits (139), Expect = 6e-09
Identities = 36/123 (29%), Positives = 62/123 (50%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
GFTPL A I+ + L+++GA + + + + +A+ G+ +IV LLL+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
++ + G T L A R V+ V LL GA + A TP+ +A LG ++ Q++
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 221 NHI 223
H+
Sbjct: 518 QHM 520
Score = 57.4 bits (137), Expect = 1e-08
Identities = 37/119 (31%), Positives = 59/119 (49%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G TPL AS G V+ LL+ G ++ + L A+ G+ +V LLLER +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
NG +PL A +G+HV+CV+ LL A + T + +A G+ +V +++
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/161 (25%), Positives = 68/161 (42%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P +L T L + N + + + + E G TP+ A+ G + V
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P + E+AL +A+ G ++V LL ++ TPL A R
Sbjct: 449 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
+ V+ LL A +GYTP+ ++ G V V+
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Score = 56.2 bits (134), Expect = 2e-08
Identities = 42/157 (26%), Positives = 69/157 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP ++++ T L R +V + L LV+ TPL AS G+ E V+
Sbjct: 455 ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQ 514
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ A P + L +++ G D+ +LLE ++ G TPL A +
Sbjct: 515 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 574
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+ + LL R A + +G TP+ +A +KV
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Score = 55.1 bits (131), Expect = 5e-08
Identities = 32/95 (33%), Positives = 50/95 (52%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G+TPLI A +G ++ V FLL+ GA+ + K + L A+ G+T I+ +LL+
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
N NG T L A R ++ V+ L ++TT
Sbjct: 788 NATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 51.2 bits (121), Expect = 8e-07
Identities = 44/172 (25%), Positives = 76/172 (44%), Gaps = 14/172 (8%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
SS ++ K +T L + + + +N + GFTPL A+ I+ V+
Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY-AVRG 177
+LLE GA+ ++ + L++A G+ V +LLE D + P L+ A R
Sbjct: 148 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV-----RLPALHIAARK 202
Query: 178 NHVKCVEALLA--RGADLTTE------ADSGYTPMDLAVALGYRKVQQVIEN 221
+ K LL AD+ ++ +SG+TP+ +A G V ++ N
Sbjct: 203 DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Score = 43.5 bits (101), Expect = 2e-04
Identities = 31/116 (26%), Positives = 54/116 (46%), Gaps = 10/116 (8%)
Query: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
A+ G ++ V L+ G D + + +AL LA+ G+ +V LL R ++ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 223
T L A + V+ L+ GA++ ++ +G+TP+ +A ENHI
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ----------ENHI 143
Score = 42.0 bits (97), Expect = 5e-04
Identities = 24/82 (29%), Positives = 41/82 (50%)
Query: 138 LSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA 197
L +A+ G ++ LLL R ++ NG TPL A + + V+ LL RG + +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 198 DSGYTPMDLAVALGYRKVQQVI 219
G TP+ A G+ +V +++
Sbjct: 297 RDGLTPLHCAARSGHDQVVELL 318
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 72.8 bits (177), Expect = 2e-13
Identities = 44/115 (38%), Positives = 62/115 (53%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+VN+ E GFTPL A+ +G + LL GA A+ + L +AS G T++V L
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
LL+R I+ +G TPL A R H + VE LL RGA L +G +P+ +A
Sbjct: 285 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 71.2 bits (173), Expect = 7e-13
Identities = 38/126 (30%), Positives = 68/126 (53%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L A+ G + V+ LL G+ K+ +AL +AS G ++V +L
Sbjct: 57 INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVL 116
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
++ +IN NG TPL A + NH+ V+ LL GA+ +T + G+TP+ +A+ G+
Sbjct: 117 VKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHN 176
Query: 214 KVQQVI 219
+ ++
Sbjct: 177 QAVAIL 182
Score = 70.9 bits (172), Expect = 9e-13
Identities = 46/164 (28%), Positives = 79/164 (48%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP ++ T L + N++ L+ N ++G TPL AS G + V
Sbjct: 620 ASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVT 679
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA+ H+ K ++L LA+ ++ +L + D + + G TPL+ A
Sbjct: 680 LLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYG 739
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
+VK V LL +GA++ + +GYTP+ A G+ + V+ H
Sbjct: 740 NVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQH 783
Score = 62.4 bits (150), Expect = 3e-10
Identities = 42/120 (35%), Positives = 60/120 (50%)
Query: 100 RGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVD 159
RG T L A+ G++E VR LL GA A+E ++ L +AS G T+IV LLL+
Sbjct: 463 RGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAH 522
Query: 160 INIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
+ NG TPL + R V LL GA + G+TP+ +A G V +++
Sbjct: 523 PDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 59.7 bits (143), Expect = 2e-09
Identities = 39/124 (31%), Positives = 54/124 (43%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
+ G TPL A+ + + LLE GA PH AK + L +A+ I LL
Sbjct: 594 KNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGA 653
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ NI G TPL A + H V LL +GA++ SG T + LA V +
Sbjct: 654 ETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADI 713
Query: 219 IENH 222
+ H
Sbjct: 714 LTKH 717
Score = 59.3 bits (142), Expect = 3e-09
Identities = 37/122 (30%), Positives = 61/122 (50%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G+TPL ++ G+++ LLE GA + K+ + L +A+ G D+ LLL+R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ NG TPL A ++ K LL +GA A +GYTP+ +A ++ +
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 221 NH 222
N+
Sbjct: 650 NY 651
Score = 58.9 bits (141), Expect = 4e-09
Identities = 40/135 (29%), Positives = 68/135 (50%), Gaps = 7/135 (5%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
+ G +PL A+ +E V+ LL+ A + + +AL +A+ G+ + LLL++
Sbjct: 330 KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRA 389
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 218
+ N NG TPL A + N +K +E L+ GA + +SG TP+ +A +G+
Sbjct: 390 NPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL----- 444
Query: 219 IENHILKLFQSNLVP 233
N +L L Q+ P
Sbjct: 445 --NIVLLLLQNGASP 457
Score = 58.2 bits (139), Expect = 6e-09
Identities = 36/123 (29%), Positives = 62/123 (50%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
GFTPL A I+ + L+++GA + + + + +A+ G+ +IV LLL+
Sbjct: 398 GFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASP 457
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
++ + G T L A R V+ V LL GA + A TP+ +A LG ++ Q++
Sbjct: 458 DVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLL 517
Query: 221 NHI 223
H+
Sbjct: 518 QHM 520
Score = 57.4 bits (137), Expect = 1e-08
Identities = 37/119 (31%), Positives = 59/119 (49%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G TPL AS G V+ LL+ G ++ + L A+ G+ +V LLLER +
Sbjct: 266 GITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPL 325
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
NG +PL A +G+HV+CV+ LL A + T + +A G+ +V +++
Sbjct: 326 LARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/161 (25%), Positives = 68/161 (42%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P +L T L + N + + + + E G TP+ A+ G + V
Sbjct: 389 ANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVL 448
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P + E+AL +A+ G ++V LL ++ TPL A R
Sbjct: 449 LLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLG 508
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
+ V+ LL A +GYTP+ ++ G V V+
Sbjct: 509 KTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVL 549
Score = 56.2 bits (134), Expect = 2e-08
Identities = 42/157 (26%), Positives = 69/157 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP ++++ T L R +V + L LV+ TPL AS G+ E V+
Sbjct: 455 ASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQ 514
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ A P + L +++ G D+ +LLE ++ G TPL A +
Sbjct: 515 LLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYG 574
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+ + LL R A + +G TP+ +A +KV
Sbjct: 575 SLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKV 611
Score = 55.1 bits (131), Expect = 5e-08
Identities = 32/95 (33%), Positives = 50/95 (52%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
G+TPLI A +G ++ V FLL+ GA+ + K + L A+ G+T I+ +LL+
Sbjct: 728 GYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKP 787
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
N NG T L A R ++ V+ L ++TT
Sbjct: 788 NATTANGNTALAIAKRLGYISVVDTLKVVTEEVTT 822
Score = 51.2 bits (121), Expect = 8e-07
Identities = 44/172 (25%), Positives = 76/172 (44%), Gaps = 14/172 (8%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
SS ++ K +T L + + + +N + GFTPL A+ I+ V+
Sbjct: 88 SSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVK 147
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY-AVRG 177
+LLE GA+ ++ + L++A G+ V +LLE D + P L+ A R
Sbjct: 148 YLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV-----RLPALHIAARK 202
Query: 178 NHVKCVEALLA--RGADLTTE------ADSGYTPMDLAVALGYRKVQQVIEN 221
+ K LL AD+ ++ +SG+TP+ +A G V ++ N
Sbjct: 203 DDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Score = 43.5 bits (101), Expect = 2e-04
Identities = 31/116 (26%), Positives = 54/116 (46%), Gaps = 10/116 (8%)
Query: 108 ASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNG 167
A+ G ++ V L+ G D + + +AL LA+ G+ +V LL R ++ G
Sbjct: 38 AARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKG 97
Query: 168 GTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 223
T L A + V+ L+ GA++ ++ +G+TP+ +A ENHI
Sbjct: 98 NTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQ----------ENHI 143
Score = 42.0 bits (97), Expect = 5e-04
Identities = 24/82 (29%), Positives = 41/82 (50%)
Query: 138 LSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEA 197
L +A+ G ++ LLL R ++ NG TPL A + + V+ LL RG + +
Sbjct: 237 LHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKT 296
Query: 198 DSGYTPMDLAVALGYRKVQQVI 219
G TP+ A G+ +V +++
Sbjct: 297 RDGLTPLHCAARSGHDQVVELL 318
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 71.6 bits (174), Expect = 5e-13
Identities = 50/141 (35%), Positives = 69/141 (48%), Gaps = 5/141 (3%)
Query: 66 LKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA 125
L H+ + N + VS L +T D VN D G+TP+IWA+ IE +R LL GA
Sbjct: 721 LHHAAKIGNLEM---VSLLLSTGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 775
Query: 126 DPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEA 185
D + E L AS G I +LL D++ +++G TPL A R ++ CV
Sbjct: 776 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 835
Query: 186 LLARGADLTTEADSGYTPMDL 206
L+RGA+ G T DL
Sbjct: 836 FLSRGANPELRNKEGDTAWDL 856
Score = 59.3 bits (142), Expect = 3e-09
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 1/129 (0%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N D++ TPL+ A +E R++++ G + ++ + L A+ G ++V LL
Sbjct: 677 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 736
Query: 154 LER-DVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
L VD+N D G TP+++A H++ + LL RGAD+T + + A G
Sbjct: 737 LSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGS 796
Query: 213 RKVQQVIEN 221
+ +V+ N
Sbjct: 797 AAIAEVLLN 805
Score = 45.1 bits (105), Expect = 5e-05
Identities = 28/102 (27%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 112 GEIETVRFLLEWGADPHILAKE--RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGT 169
GE++ V +L DP+ + + + + L A+ G +I +LL+ +IN D T
Sbjct: 627 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 686
Query: 170 PLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 211
PL+ AV NH++ ++ RG + ++ + G T + A +G
Sbjct: 687 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 728
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 71.6 bits (174), Expect = 5e-13
Identities = 50/141 (35%), Positives = 69/141 (48%), Gaps = 5/141 (3%)
Query: 66 LKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA 125
L H+ + N + VS L +T D VN D G+TP+IWA+ IE +R LL GA
Sbjct: 755 LHHAAKIGNLEM---VSLLLSTGQVD--VNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGA 809
Query: 126 DPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEA 185
D + E L AS G I +LL D++ +++G TPL A R ++ CV
Sbjct: 810 DVTLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLL 869
Query: 186 LLARGADLTTEADSGYTPMDL 206
L+RGA+ G T DL
Sbjct: 870 FLSRGANPELRNKEGDTAWDL 890
Score = 59.3 bits (142), Expect = 3e-09
Identities = 36/129 (27%), Positives = 65/129 (50%), Gaps = 1/129 (0%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N D++ TPL+ A +E R++++ G + ++ + L A+ G ++V LL
Sbjct: 711 INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIGNLEMVSLL 770
Query: 154 LER-DVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
L VD+N D G TP+++A H++ + LL RGAD+T + + A G
Sbjct: 771 LSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADVTLTDNEENICLHWASFTGS 830
Query: 213 RKVQQVIEN 221
+ +V+ N
Sbjct: 831 AAIAEVLLN 839
Score = 45.1 bits (105), Expect = 5e-05
Identities = 28/102 (27%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 112 GEIETVRFLLEWGADPHILAKE--RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGT 169
GE++ V +L DP+ + + + + L A+ G +I +LL+ +IN D T
Sbjct: 661 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 720
Query: 170 PLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 211
PL+ AV NH++ ++ RG + ++ + G T + A +G
Sbjct: 721 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 762
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 71.2 bits (173), Expect = 7e-13
Identities = 46/131 (35%), Positives = 72/131 (54%), Gaps = 4/131 (3%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
N+ DE G+ PL +A+ G+ T R LL+ GA +E + L LA+ + ++ LL+
Sbjct: 422 NRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLV 481
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 214
R D N+++ G TPL A HV V+ L ++GA+L + + TP+ LAV G K
Sbjct: 482 SRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERG--K 539
Query: 215 VQQVIENHILK 225
V+ + H+LK
Sbjct: 540 VRAI--QHLLK 548
Score = 60.5 bits (145), Expect = 1e-09
Identities = 46/148 (31%), Positives = 72/148 (48%), Gaps = 2/148 (1%)
Query: 76 QRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE 135
+RG +V A+ L + + D+ G+ PL A+A G+ + LL +GA + +
Sbjct: 536 ERG-KVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGW 594
Query: 136 SALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
+ L LA+ G+ +I+ LL E ++ TPL A R V ALL GAD
Sbjct: 595 TPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNA 654
Query: 196 EADSGYTPMDLAVALG-YRKVQQVIENH 222
SG+TP+ LAV + V ++E+H
Sbjct: 655 AEQSGWTPLHLAVQRSTFLSVINLLEHH 682
Score = 55.1 bits (131), Expect = 5e-08
Identities = 43/156 (27%), Positives = 64/156 (41%), Gaps = 5/156 (3%)
Query: 69 STTLTNRQRGNEVSALPATLDCDNLVNKPDE-----RGFTPLIWASAFGEIETVRFLLEW 123
S L + GN + D NLV + +E TPL + A G +E VR LL
Sbjct: 325 SQELMDSDSGNYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAH 384
Query: 124 GADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 183
D + L +A+ D+ LLL D N D +G PL +A +
Sbjct: 385 EVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTA 444
Query: 184 EALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
LL GA + + G+TP+ LA + V +++
Sbjct: 445 RLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLL 480
Score = 52.4 bits (124), Expect = 3e-07
Identities = 38/123 (30%), Positives = 58/123 (47%)
Query: 97 PDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLER 156
P +G+TPL A+ G +E + L E A+ L + L LA+ G +V LL+
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQC 648
Query: 157 DVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQ 216
D N + +G TPL AV+ + V LL A++ G+TP LA G +
Sbjct: 649 GADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAIL 708
Query: 217 QVI 219
+V+
Sbjct: 709 KVL 711
Score = 48.9 bits (115), Expect = 4e-06
Identities = 39/130 (30%), Positives = 61/130 (46%), Gaps = 3/130 (2%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
N + G TPL A+ FG + V+ L GA+ + + L LA G + LL
Sbjct: 488 NLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLL 547
Query: 155 ERDVDINIYDWNGGTPL-LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ + D +G PL A RG ++ C + LL GA L G+TP+ LA G+
Sbjct: 548 KSGAVPDALDQSGYGPLHTAAARGKYLIC-KMLLRYGASLELPTHQGWTPLHLAAYKGHL 606
Query: 214 KVQQVI-ENH 222
++ ++ E+H
Sbjct: 607 EIIHLLAESH 616
Score = 42.0 bits (97), Expect = 5e-04
Identities = 31/113 (27%), Positives = 48/113 (42%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL A G++ ++ LL+ GA P L + L A+ G I +LL + +
Sbjct: 529 TPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLEL 588
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
G TPL A H++ + L A++ +TP+ LA G V
Sbjct: 589 PTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAV 641
Score = 42.0 bits (97), Expect = 5e-04
Identities = 33/119 (27%), Positives = 53/119 (44%)
Query: 102 FTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 161
+TPL A+ GE V LL+ GADP+ + + L LA V LLE +++
Sbjct: 627 WTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVH 686
Query: 162 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ G TP A + ++ L+ GA L + TP+ LA+ + + +E
Sbjct: 687 ARNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLE 745
Score = 41.2 bits (95), Expect = 8e-04
Identities = 33/107 (30%), Positives = 49/107 (45%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L R E + + A L C N ++ G+TPL A +V LLE A+ H
Sbjct: 628 TPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHA 687
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVR 176
K + LA+ G T I+ +L+E +++ D TPL A+R
Sbjct: 688 RNKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734
Score = 40.8 bits (94), Expect = 0.001
Identities = 24/78 (30%), Positives = 37/78 (47%)
Query: 145 GYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPM 204
G + V LLL +VD++ +G TPLL A + LLA GAD + G+ P+
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
Query: 205 DLAVALGYRKVQQVIENH 222
A G +++ +H
Sbjct: 433 HFAAQNGDDGTARLLLDH 450
>gi|18640738 ankyrin repeat, SAM and basic leucine zipper domain
containing 1 [Homo sapiens]
Length = 475
Score = 71.2 bits (173), Expect = 7e-13
Identities = 43/140 (30%), Positives = 74/140 (52%), Gaps = 4/140 (2%)
Query: 80 EVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALS 139
+VS + LD V+ + G+TPL++A++ E VR LL+ GA+ ++ ++
Sbjct: 58 DVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGANASFEKDKQSILIT 117
Query: 140 LASTGGYTD----IVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
S G + V LLL R+ D N+ TP++YA R H + V L+A GA++ T
Sbjct: 118 ACSAHGSEEQILKCVELLLSRNADPNVACRRLMTPIMYAARDGHTQVVALLVAHGAEVNT 177
Query: 196 EADSGYTPMDLAVALGYRKV 215
+ ++GYT + A G++ +
Sbjct: 178 QDENGYTALTWAARQGHKNI 197
Score = 37.4 bits (85), Expect = 0.011
Identities = 21/60 (35%), Positives = 30/60 (50%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN DE G+T L WA+ G V LLE GA+ + K+ + +A + +I LL
Sbjct: 175 VNTQDENGYTALTWAARQGHKNIVLKLLELGANKMLQTKDGKMPSEIAKRNKHHEIFNLL 234
Score = 35.4 bits (80), Expect = 0.043
Identities = 21/67 (31%), Positives = 34/67 (50%)
Query: 132 KERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGA 191
+E++ A T G +V LL+ + ++ G TPL+YA + + V LL RGA
Sbjct: 44 EEKKEKFKKAMTIGDVSLVQELLDSGISVDSNFQYGWTPLMYAASVANAELVRVLLDRGA 103
Query: 192 DLTTEAD 198
+ + E D
Sbjct: 104 NASFEKD 110
Score = 34.3 bits (77), Expect = 0.097
Identities = 23/80 (28%), Positives = 40/80 (50%)
Query: 100 RGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVD 159
R TP+++A+ G + V L+ GA+ + + +AL+ A+ G+ +IV LLE +
Sbjct: 148 RLMTPIMYAARDGHTQVVALLVAHGAEVNTQDENGYTALTWAARQGHKNIVLKLLELGAN 207
Query: 160 INIYDWNGGTPLLYAVRGNH 179
+ +G P A R H
Sbjct: 208 KMLQTKDGKMPSEIAKRNKH 227
>gi|34304381 inversin isoform a [Homo sapiens]
Length = 1065
Score = 70.5 bits (171), Expect = 1e-12
Identities = 46/182 (25%), Positives = 85/182 (46%), Gaps = 10/182 (5%)
Query: 31 AADGSDTVVLSLFPCTPEPVNPEPDASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDC 90
A GSD V+ ++ + + D +++ G + H+ L+ VS + L+
Sbjct: 330 AGKGSDDVLRTMLS-----LKSDIDINMADKYGGTALHAAALSGH-----VSTVKLLLEN 379
Query: 91 DNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 150
+ V+ D TPL A G + ++ L++ GA ++ ++ S L A+ GG D+
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439
Query: 151 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVAL 210
+L+E ++ N+ D+ G TPL A G ++ C+ L+ AD + G T + +
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
Query: 211 GY 212
GY
Sbjct: 500 GY 501
Score = 54.7 bits (130), Expect = 7e-08
Identities = 38/137 (27%), Positives = 70/137 (51%), Gaps = 5/137 (3%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
V+ D+ G + L WA+ G + + L+E +P++ + L A+ GGY + + +L
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL--ARGADLTTEADSGYTPMDLAVALG 211
+E + D NI D G T L ++ ++ ++ LL A + + YTP+D A+ LG
Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL-LG 534
Query: 212 YRK--VQQVIENHILKL 226
R +Q ++E+ L +
Sbjct: 535 ERHEVIQFMLEHGALSI 551
Score = 52.8 bits (125), Expect = 3e-07
Identities = 38/124 (30%), Positives = 60/124 (48%), Gaps = 2/124 (1%)
Query: 98 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG--LLLE 155
D +G TPL +A+ ETV+ L+ + E ++ A+ G D++ L L+
Sbjct: 286 DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLK 345
Query: 156 RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
D+DIN+ D GGT L A HV V+ LL A + +TP+ A +G++ V
Sbjct: 346 SDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDV 405
Query: 216 QQVI 219
Q +
Sbjct: 406 IQTL 409
Score = 41.2 bits (95), Expect = 8e-04
Identities = 42/175 (24%), Positives = 79/175 (45%), Gaps = 15/175 (8%)
Query: 72 LTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILA 131
LT R R + AL V+ D+ T L W++ + E V+ L++ D +I
Sbjct: 120 LTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKH--DSNIGI 177
Query: 132 KERESALSLASTGGYTD-----IVGLLLER---DVDINIYDWNGGTPLLYAVRGNHVKCV 183
+ E + L + D V +L+ + +N D+ G TPL +AV +V V
Sbjct: 178 PDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVV 237
Query: 184 EALLA-RGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE 237
+ L + ++T+ + TP+ A LG+ ++ + +L+ +S +P+D +
Sbjct: 238 DVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHL----LLERNKSGTIPSDSQ 288
Score = 40.0 bits (92), Expect = 0.002
Identities = 30/95 (31%), Positives = 44/95 (46%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
L +K D+ G TPL++ ++ LL+ GAD + + +AL LA+ G + L
Sbjct: 40 LKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKL 99
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 187
LL R + D TPL R KC+ LL
Sbjct: 100 LLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Score = 37.7 bits (86), Expect = 0.009
Identities = 22/73 (30%), Positives = 33/73 (45%)
Query: 164 DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 223
D G TPL+Y V + + C +ALL GAD+ S T + LA G + +++
Sbjct: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
Query: 224 LKLFQSNLVPADP 236
Q +L P
Sbjct: 105 ANWMQKDLEEMTP 117
>gi|34304379 inversin isoform b [Homo sapiens]
Length = 895
Score = 70.5 bits (171), Expect = 1e-12
Identities = 46/182 (25%), Positives = 85/182 (46%), Gaps = 10/182 (5%)
Query: 31 AADGSDTVVLSLFPCTPEPVNPEPDASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDC 90
A GSD V+ ++ + + D +++ G + H+ L+ VS + L+
Sbjct: 330 AGKGSDDVLRTMLS-----LKSDIDINMADKYGGTALHAAALSGH-----VSTVKLLLEN 379
Query: 91 DNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 150
+ V+ D TPL A G + ++ L++ GA ++ ++ S L A+ GG D+
Sbjct: 380 NAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 439
Query: 151 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVAL 210
+L+E ++ N+ D+ G TPL A G ++ C+ L+ AD + G T + +
Sbjct: 440 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNN 499
Query: 211 GY 212
GY
Sbjct: 500 GY 501
Score = 54.7 bits (130), Expect = 7e-08
Identities = 38/137 (27%), Positives = 70/137 (51%), Gaps = 5/137 (3%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
V+ D+ G + L WA+ G + + L+E +P++ + L A+ GGY + + +L
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL--ARGADLTTEADSGYTPMDLAVALG 211
+E + D NI D G T L ++ ++ ++ LL A + + YTP+D A+ LG
Sbjct: 476 MENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYAL-LG 534
Query: 212 YRK--VQQVIENHILKL 226
R +Q ++E+ L +
Sbjct: 535 ERHEVIQFMLEHGALSI 551
Score = 52.8 bits (125), Expect = 3e-07
Identities = 38/124 (30%), Positives = 60/124 (48%), Gaps = 2/124 (1%)
Query: 98 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG--LLLE 155
D +G TPL +A+ ETV+ L+ + E ++ A+ G D++ L L+
Sbjct: 286 DSQGATPLHYAAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLK 345
Query: 156 RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
D+DIN+ D GGT L A HV V+ LL A + +TP+ A +G++ V
Sbjct: 346 SDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDV 405
Query: 216 QQVI 219
Q +
Sbjct: 406 IQTL 409
Score = 41.2 bits (95), Expect = 8e-04
Identities = 42/175 (24%), Positives = 79/175 (45%), Gaps = 15/175 (8%)
Query: 72 LTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILA 131
LT R R + AL V+ D+ T L W++ + E V+ L++ D +I
Sbjct: 120 LTTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKH--DSNIGI 177
Query: 132 KERESALSLASTGGYTD-----IVGLLLER---DVDINIYDWNGGTPLLYAVRGNHVKCV 183
+ E + L + D V +L+ + +N D+ G TPL +AV +V V
Sbjct: 178 PDVEGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVV 237
Query: 184 EALLA-RGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADPE 237
+ L + ++T+ + TP+ A LG+ ++ + +L+ +S +P+D +
Sbjct: 238 DVLTSYESCNITSYDNLFRTPLHWAALLGHAQIVHL----LLERNKSGTIPSDSQ 288
Score = 40.0 bits (92), Expect = 0.002
Identities = 30/95 (31%), Positives = 44/95 (46%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
L +K D+ G TPL++ ++ LL+ GAD + + +AL LA+ G + L
Sbjct: 40 LKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKL 99
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 187
LL R + D TPL R KC+ LL
Sbjct: 100 LLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLL 134
Score = 37.7 bits (86), Expect = 0.009
Identities = 22/73 (30%), Positives = 33/73 (45%)
Query: 164 DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 223
D G TPL+Y V + + C +ALL GAD+ S T + LA G + +++
Sbjct: 45 DQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRR 104
Query: 224 LKLFQSNLVPADP 236
Q +L P
Sbjct: 105 ANWMQKDLEEMTP 117
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 69.3 bits (168), Expect = 3e-12
Identities = 44/154 (28%), Positives = 72/154 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+ P +L T L + N V + L ++ E G TPL AS G + V+
Sbjct: 395 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 454
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P++ + E+ L +A+ G+T++ LL+ +N + TPL A R
Sbjct: 455 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 514
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
H V+ LL A+ +G+TP+ +A G+
Sbjct: 515 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 548
Score = 68.9 bits (167), Expect = 4e-12
Identities = 48/157 (30%), Positives = 73/157 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P ++ T L R V + A L+ + ++GFTPL A+ +G++
Sbjct: 527 ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 586
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A P+ K + L +A DIV LLL R + WNG TPL A + N
Sbjct: 587 LLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 646
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 647 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683
Score = 66.2 bits (160), Expect = 2e-11
Identities = 40/117 (34%), Positives = 64/117 (54%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL A+ G E ++LL+ A + AK+ ++ L A+ G+T++V LLLE + + N+
Sbjct: 472 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 531
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
G TPL A R HV+ V ALL + A G+TP+ +A G +V +++
Sbjct: 532 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 588
Score = 64.7 bits (156), Expect = 7e-11
Identities = 40/126 (31%), Positives = 62/126 (49%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN + G TPL AS G + VR LL+ GA K+ + L A+ G+ I +L
Sbjct: 265 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 324
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
L+ I NG +P+ A +G+H+ CV LL A++ TP+ +A G+
Sbjct: 325 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 384
Query: 214 KVQQVI 219
+V +V+
Sbjct: 385 RVAKVL 390
Score = 63.5 bits (153), Expect = 1e-10
Identities = 36/128 (28%), Positives = 65/128 (50%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+ P G+TPL A+ ++E R LL++G + + + + L LA+ G+ ++V LLL
Sbjct: 629 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 688
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 214
+ + N+ + +G TPL + HV + L+ G + GYTP+ +A G K
Sbjct: 689 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 748
Query: 215 VQQVIENH 222
+ + + H
Sbjct: 749 LVKFLLQH 756
Score = 62.8 bits (151), Expect = 3e-10
Identities = 40/143 (27%), Positives = 69/143 (48%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L R V LD + + G +P+ A+ ++ VR LL++ A+
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+ + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E LL
Sbjct: 367 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 426
Query: 190 GADLTTEADSGYTPMDLAVALGY 212
GA + +SG TP+ +A +G+
Sbjct: 427 GASIDAVTESGLTPLHVASFMGH 449
Score = 60.1 bits (144), Expect = 2e-09
Identities = 44/150 (29%), Positives = 65/150 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP S++K T L R L VN + TPL A+ G V+
Sbjct: 461 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 520
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A+P++ + L +A+ G+ + V LLE++ G TPL A +
Sbjct: 521 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 580
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAV 208
V+ E LL R A +G TP+ +AV
Sbjct: 581 KVRVAELLLERDAHPNAAGKNGLTPLHVAV 610
Score = 59.3 bits (142), Expect = 3e-09
Identities = 36/129 (27%), Positives = 63/129 (48%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L AS G ++ V LL K+ +AL +A+ G ++V L
Sbjct: 71 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 130
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ ++N G TPL A + NH++ V+ LL GA+ + G+TP+ +A+ G+
Sbjct: 131 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 190
Query: 214 KVQQVIENH 222
V + N+
Sbjct: 191 NVVAHLINY 199
Score = 57.8 bits (138), Expect = 8e-09
Identities = 41/144 (28%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Query: 76 QRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE 135
+RGN V + LD + + TPL A+ G + LL+ GA K
Sbjct: 281 RRGN-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 339
Query: 136 SALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +GA +
Sbjct: 340 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 399
Query: 196 EADSGYTPMDLAVALGYRKVQQVI 219
A +G+TP+ +A + +V +++
Sbjct: 400 RALNGFTPLHIACKKNHVRVMELL 423
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/156 (26%), Positives = 68/156 (43%)
Query: 60 SPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRF 119
SP + T L + N+V + L N +G TPL A+ G E V
Sbjct: 627 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 686
Query: 120 LLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNH 179
LL A+ ++ K + L L + G+ + +L++ V ++ G TPL A +
Sbjct: 687 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 746
Query: 180 VKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+K V+ LL AD+ + GY+P+ A G+ +
Sbjct: 747 IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782
Score = 56.2 bits (134), Expect = 2e-08
Identities = 40/131 (30%), Positives = 63/131 (48%), Gaps = 4/131 (3%)
Query: 96 KPDER---GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
KP+ R GFTPL A + + LL+ GA + + + L +AS G+ IV
Sbjct: 396 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 455
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
LL+R N+ + TPL A R H + + LL A + +A TP+ A +G+
Sbjct: 456 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 515
Query: 213 -RKVQQVIENH 222
V+ ++EN+
Sbjct: 516 TNMVKLLLENN 526
Score = 56.2 bits (134), Expect = 2e-08
Identities = 35/94 (37%), Positives = 50/94 (53%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+V+ G+TPL AS +G I+ V+FLL+ AD + K S L A+ G+TDIV L
Sbjct: 726 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 785
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
LL+ N +G TPL A R ++ + L
Sbjct: 786 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 55.8 bits (133), Expect = 3e-08
Identities = 48/187 (25%), Positives = 74/187 (39%), Gaps = 29/187 (15%)
Query: 65 SLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 124
S K T L + N + + L+ N E GFTPL A G V L+ +G
Sbjct: 141 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Query: 125 A-----------------------------DPHILAKERESALSLASTGGYTDIVGLLLE 155
+P +L+K + L +A+ ++ LLL
Sbjct: 201 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 260
Query: 156 RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
R +N NG TPL A R +V V LL RGA + T+ TP+ A G+ ++
Sbjct: 261 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 320
Query: 216 QQVIENH 222
+++ +H
Sbjct: 321 SEILLDH 327
Score = 55.5 bits (132), Expect = 4e-08
Identities = 35/107 (32%), Positives = 53/107 (49%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
GFTPL A+ + + + LL GA + + + L +AS G +V LLL+R I
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
+ TPL A R HV+ E LL GA + + +G +P+ +A
Sbjct: 299 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 345
Score = 54.7 bits (130), Expect = 7e-08
Identities = 43/156 (27%), Positives = 64/156 (41%)
Query: 67 KHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGAD 126
K T L + +V L+ D N + G TPL A ++ V+ LL G
Sbjct: 568 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 627
Query: 127 PHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
PH A + L +A+ ++ LL+ N G TPL A + H + V L
Sbjct: 628 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 687
Query: 187 LARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L++ A+ SG TP+ L G+ V V+ H
Sbjct: 688 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Score = 53.5 bits (127), Expect = 2e-07
Identities = 48/166 (28%), Positives = 72/166 (43%), Gaps = 7/166 (4%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCD-NLVNKPDERGFTPLIWASAFGEI 114
A+ S QG + H L ++ E+ AL + + NL NK G TPL + G +
Sbjct: 661 ANAESVQGVTPLH---LAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 714
Query: 115 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
L++ G + + L +AS G +V LL+ D+N G +PL A
Sbjct: 715 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 774
Query: 175 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ H V LL GA + G TP+ +A LGY V V++
Sbjct: 775 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
Score = 47.0 bits (110), Expect = 1e-05
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 7/139 (5%)
Query: 88 LDCDNLVNKPDER-------GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSL 140
LDC L+ + D TPL A+ G + LL+ GA P+ A + L +
Sbjct: 351 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 410
Query: 141 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 200
A + ++ LLL+ I+ +G TPL A H+ V+ LL RGA
Sbjct: 411 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 470
Query: 201 YTPMDLAVALGYRKVQQVI 219
TP+ +A G+ +V + +
Sbjct: 471 ETPLHMAARAGHTEVAKYL 489
Score = 43.5 bits (101), Expect = 2e-04
Identities = 27/92 (29%), Positives = 50/92 (54%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + ++V LLE
Sbjct: 109 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 168
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARG 190
+ N+ +G TPL A++ H V L+ G
Sbjct: 169 NQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 47 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 106
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 221
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 107 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 166
Score = 35.0 bits (79), Expect = 0.057
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 132 KERESALSL--ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
K+ ++A S A+ G D L VDIN + NG L A + HVK V LL +
Sbjct: 41 KKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 100
Query: 190 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L T G T + +A G +V + + N+
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNY 133
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 69.3 bits (168), Expect = 3e-12
Identities = 44/154 (28%), Positives = 72/154 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+ P +L T L + N V + L ++ E G TPL AS G + V+
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P++ + E+ L +A+ G+T++ LL+ +N + TPL A R
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
H V+ LL A+ +G+TP+ +A G+
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 68.9 bits (167), Expect = 4e-12
Identities = 48/157 (30%), Positives = 73/157 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P ++ T L R V + A L+ + ++GFTPL A+ +G++
Sbjct: 494 ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 553
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A P+ K + L +A DIV LLL R + WNG TPL A + N
Sbjct: 554 LLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Score = 66.2 bits (160), Expect = 2e-11
Identities = 40/117 (34%), Positives = 64/117 (54%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL A+ G E ++LL+ A + AK+ ++ L A+ G+T++V LLLE + + N+
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
G TPL A R HV+ V ALL + A G+TP+ +A G +V +++
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 64.7 bits (156), Expect = 7e-11
Identities = 40/126 (31%), Positives = 62/126 (49%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN + G TPL AS G + VR LL+ GA K+ + L A+ G+ I +L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
L+ I NG +P+ A +G+H+ CV LL A++ TP+ +A G+
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
Query: 214 KVQQVI 219
+V +V+
Sbjct: 352 RVAKVL 357
Score = 63.5 bits (153), Expect = 1e-10
Identities = 36/128 (28%), Positives = 65/128 (50%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+ P G+TPL A+ ++E R LL++G + + + + L LA+ G+ ++V LLL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 214
+ + N+ + +G TPL + HV + L+ G + GYTP+ +A G K
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 215 VQQVIENH 222
+ + + H
Sbjct: 716 LVKFLLQH 723
Score = 62.8 bits (151), Expect = 3e-10
Identities = 40/143 (27%), Positives = 69/143 (48%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L R V LD + + G +P+ A+ ++ VR LL++ A+
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+ + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E LL
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 190 GADLTTEADSGYTPMDLAVALGY 212
GA + +SG TP+ +A +G+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416
Score = 60.1 bits (144), Expect = 2e-09
Identities = 44/150 (29%), Positives = 65/150 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP S++K T L R L VN + TPL A+ G V+
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A+P++ + L +A+ G+ + V LLE++ G TPL A +
Sbjct: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAV 208
V+ E LL R A +G TP+ +AV
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Score = 59.3 bits (142), Expect = 3e-09
Identities = 36/129 (27%), Positives = 63/129 (48%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L AS G ++ V LL K+ +AL +A+ G ++V L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ ++N G TPL A + NH++ V+ LL GA+ + G+TP+ +A+ G+
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 214 KVQQVIENH 222
V + N+
Sbjct: 158 NVVAHLINY 166
Score = 57.8 bits (138), Expect = 8e-09
Identities = 41/144 (28%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Query: 76 QRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE 135
+RGN V + LD + + TPL A+ G + LL+ GA K
Sbjct: 248 RRGN-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Query: 136 SALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +GA +
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 196 EADSGYTPMDLAVALGYRKVQQVI 219
A +G+TP+ +A + +V +++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELL 390
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/156 (26%), Positives = 68/156 (43%)
Query: 60 SPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRF 119
SP + T L + N+V + L N +G TPL A+ G E V
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 120 LLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNH 179
LL A+ ++ K + L L + G+ + +L++ V ++ G TPL A +
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 713
Query: 180 VKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+K V+ LL AD+ + GY+P+ A G+ +
Sbjct: 714 IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 56.2 bits (134), Expect = 2e-08
Identities = 40/131 (30%), Positives = 63/131 (48%), Gaps = 4/131 (3%)
Query: 96 KPDER---GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
KP+ R GFTPL A + + LL+ GA + + + L +AS G+ IV
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
LL+R N+ + TPL A R H + + LL A + +A TP+ A +G+
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 213 -RKVQQVIENH 222
V+ ++EN+
Sbjct: 483 TNMVKLLLENN 493
Score = 56.2 bits (134), Expect = 2e-08
Identities = 35/94 (37%), Positives = 50/94 (53%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+V+ G+TPL AS +G I+ V+FLL+ AD + K S L A+ G+TDIV L
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
LL+ N +G TPL A R ++ + L
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 55.8 bits (133), Expect = 3e-08
Identities = 48/187 (25%), Positives = 74/187 (39%), Gaps = 29/187 (15%)
Query: 65 SLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 124
S K T L + N + + L+ N E GFTPL A G V L+ +G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 125 A-----------------------------DPHILAKERESALSLASTGGYTDIVGLLLE 155
+P +L+K + L +A+ ++ LLL
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 156 RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
R +N NG TPL A R +V V LL RGA + T+ TP+ A G+ ++
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 216 QQVIENH 222
+++ +H
Sbjct: 288 SEILLDH 294
Score = 55.5 bits (132), Expect = 4e-08
Identities = 35/107 (32%), Positives = 53/107 (49%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
GFTPL A+ + + + LL GA + + + L +AS G +V LLL+R I
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
+ TPL A R HV+ E LL GA + + +G +P+ +A
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Score = 54.7 bits (130), Expect = 7e-08
Identities = 43/156 (27%), Positives = 64/156 (41%)
Query: 67 KHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGAD 126
K T L + +V L+ D N + G TPL A ++ V+ LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 127 PHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
PH A + L +A+ ++ LL+ N G TPL A + H + V L
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 187 LARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L++ A+ SG TP+ L G+ V V+ H
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 53.5 bits (127), Expect = 2e-07
Identities = 48/166 (28%), Positives = 72/166 (43%), Gaps = 7/166 (4%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCD-NLVNKPDERGFTPLIWASAFGEI 114
A+ S QG + H L ++ E+ AL + + NL NK G TPL + G +
Sbjct: 628 ANAESVQGVTPLH---LAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 681
Query: 115 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
L++ G + + L +AS G +V LL+ D+N G +PL A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 175 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ H V LL GA + G TP+ +A LGY V V++
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 47.0 bits (110), Expect = 1e-05
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 7/139 (5%)
Query: 88 LDCDNLVNKPDER-------GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSL 140
LDC L+ + D TPL A+ G + LL+ GA P+ A + L +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Query: 141 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 200
A + ++ LLL+ I+ +G TPL A H+ V+ LL RGA
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 201 YTPMDLAVALGYRKVQQVI 219
TP+ +A G+ +V + +
Sbjct: 438 ETPLHMAARAGHTEVAKYL 456
Score = 43.5 bits (101), Expect = 2e-04
Identities = 27/92 (29%), Positives = 50/92 (54%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + ++V LLE
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARG 190
+ N+ +G TPL A++ H V L+ G
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 221
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Score = 35.4 bits (80), Expect = 0.043
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 132 KERESALSL--ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+E ++A S A+ G D L VDIN + NG L A + HVK V LL +
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 190 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L T G T + +A G +V + + N+
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 69.3 bits (168), Expect = 3e-12
Identities = 44/154 (28%), Positives = 72/154 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+ P +L T L + N V + L ++ E G TPL AS G + V+
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P++ + E+ L +A+ G+T++ LL+ +N + TPL A R
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
H V+ LL A+ +G+TP+ +A G+
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 68.9 bits (167), Expect = 4e-12
Identities = 48/157 (30%), Positives = 73/157 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P ++ T L R V + A L+ + ++GFTPL A+ +G++
Sbjct: 494 ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 553
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A P+ K + L +A DIV LLL R + WNG TPL A + N
Sbjct: 554 LLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Score = 66.2 bits (160), Expect = 2e-11
Identities = 40/117 (34%), Positives = 64/117 (54%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL A+ G E ++LL+ A + AK+ ++ L A+ G+T++V LLLE + + N+
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
G TPL A R HV+ V ALL + A G+TP+ +A G +V +++
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 64.7 bits (156), Expect = 7e-11
Identities = 40/126 (31%), Positives = 62/126 (49%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN + G TPL AS G + VR LL+ GA K+ + L A+ G+ I +L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
L+ I NG +P+ A +G+H+ CV LL A++ TP+ +A G+
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
Query: 214 KVQQVI 219
+V +V+
Sbjct: 352 RVAKVL 357
Score = 63.5 bits (153), Expect = 1e-10
Identities = 36/128 (28%), Positives = 65/128 (50%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+ P G+TPL A+ ++E R LL++G + + + + L LA+ G+ ++V LLL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 214
+ + N+ + +G TPL + HV + L+ G + GYTP+ +A G K
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 215 VQQVIENH 222
+ + + H
Sbjct: 716 LVKFLLQH 723
Score = 62.8 bits (151), Expect = 3e-10
Identities = 40/143 (27%), Positives = 69/143 (48%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L R V LD + + G +P+ A+ ++ VR LL++ A+
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+ + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E LL
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 190 GADLTTEADSGYTPMDLAVALGY 212
GA + +SG TP+ +A +G+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416
Score = 60.1 bits (144), Expect = 2e-09
Identities = 44/150 (29%), Positives = 65/150 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP S++K T L R L VN + TPL A+ G V+
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A+P++ + L +A+ G+ + V LLE++ G TPL A +
Sbjct: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAV 208
V+ E LL R A +G TP+ +AV
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Score = 59.3 bits (142), Expect = 3e-09
Identities = 36/129 (27%), Positives = 63/129 (48%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L AS G ++ V LL K+ +AL +A+ G ++V L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ ++N G TPL A + NH++ V+ LL GA+ + G+TP+ +A+ G+
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 214 KVQQVIENH 222
V + N+
Sbjct: 158 NVVAHLINY 166
Score = 57.8 bits (138), Expect = 8e-09
Identities = 41/144 (28%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Query: 76 QRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE 135
+RGN V + LD + + TPL A+ G + LL+ GA K
Sbjct: 248 RRGN-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Query: 136 SALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +GA +
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 196 EADSGYTPMDLAVALGYRKVQQVI 219
A +G+TP+ +A + +V +++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELL 390
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/156 (26%), Positives = 68/156 (43%)
Query: 60 SPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRF 119
SP + T L + N+V + L N +G TPL A+ G E V
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 120 LLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNH 179
LL A+ ++ K + L L + G+ + +L++ V ++ G TPL A +
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 713
Query: 180 VKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+K V+ LL AD+ + GY+P+ A G+ +
Sbjct: 714 IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 56.2 bits (134), Expect = 2e-08
Identities = 40/131 (30%), Positives = 63/131 (48%), Gaps = 4/131 (3%)
Query: 96 KPDER---GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
KP+ R GFTPL A + + LL+ GA + + + L +AS G+ IV
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
LL+R N+ + TPL A R H + + LL A + +A TP+ A +G+
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 213 -RKVQQVIENH 222
V+ ++EN+
Sbjct: 483 TNMVKLLLENN 493
Score = 56.2 bits (134), Expect = 2e-08
Identities = 35/94 (37%), Positives = 50/94 (53%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+V+ G+TPL AS +G I+ V+FLL+ AD + K S L A+ G+TDIV L
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
LL+ N +G TPL A R ++ + L
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 55.8 bits (133), Expect = 3e-08
Identities = 48/187 (25%), Positives = 74/187 (39%), Gaps = 29/187 (15%)
Query: 65 SLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 124
S K T L + N + + L+ N E GFTPL A G V L+ +G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 125 A-----------------------------DPHILAKERESALSLASTGGYTDIVGLLLE 155
+P +L+K + L +A+ ++ LLL
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 156 RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
R +N NG TPL A R +V V LL RGA + T+ TP+ A G+ ++
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 216 QQVIENH 222
+++ +H
Sbjct: 288 SEILLDH 294
Score = 55.5 bits (132), Expect = 4e-08
Identities = 35/107 (32%), Positives = 53/107 (49%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
GFTPL A+ + + + LL GA + + + L +AS G +V LLL+R I
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
+ TPL A R HV+ E LL GA + + +G +P+ +A
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Score = 54.7 bits (130), Expect = 7e-08
Identities = 43/156 (27%), Positives = 64/156 (41%)
Query: 67 KHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGAD 126
K T L + +V L+ D N + G TPL A ++ V+ LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 127 PHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
PH A + L +A+ ++ LL+ N G TPL A + H + V L
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 187 LARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L++ A+ SG TP+ L G+ V V+ H
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 53.5 bits (127), Expect = 2e-07
Identities = 48/166 (28%), Positives = 72/166 (43%), Gaps = 7/166 (4%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCD-NLVNKPDERGFTPLIWASAFGEI 114
A+ S QG + H L ++ E+ AL + + NL NK G TPL + G +
Sbjct: 628 ANAESVQGVTPLH---LAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 681
Query: 115 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
L++ G + + L +AS G +V LL+ D+N G +PL A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 175 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ H V LL GA + G TP+ +A LGY V V++
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 47.0 bits (110), Expect = 1e-05
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 7/139 (5%)
Query: 88 LDCDNLVNKPDER-------GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSL 140
LDC L+ + D TPL A+ G + LL+ GA P+ A + L +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Query: 141 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 200
A + ++ LLL+ I+ +G TPL A H+ V+ LL RGA
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 201 YTPMDLAVALGYRKVQQVI 219
TP+ +A G+ +V + +
Sbjct: 438 ETPLHMAARAGHTEVAKYL 456
Score = 43.5 bits (101), Expect = 2e-04
Identities = 27/92 (29%), Positives = 50/92 (54%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + ++V LLE
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARG 190
+ N+ +G TPL A++ H V L+ G
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 221
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Score = 35.4 bits (80), Expect = 0.043
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 132 KERESALSL--ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+E ++A S A+ G D L VDIN + NG L A + HVK V LL +
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 190 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L T G T + +A G +V + + N+
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 69.3 bits (168), Expect = 3e-12
Identities = 44/154 (28%), Positives = 72/154 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+ P +L T L + N V + L ++ E G TPL AS G + V+
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P++ + E+ L +A+ G+T++ LL+ +N + TPL A R
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
H V+ LL A+ +G+TP+ +A G+
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 68.9 bits (167), Expect = 4e-12
Identities = 48/157 (30%), Positives = 73/157 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P ++ T L R V + A L+ + ++GFTPL A+ +G++
Sbjct: 494 ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 553
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A P+ K + L +A DIV LLL R + WNG TPL A + N
Sbjct: 554 LLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Score = 66.2 bits (160), Expect = 2e-11
Identities = 40/117 (34%), Positives = 64/117 (54%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL A+ G E ++LL+ A + AK+ ++ L A+ G+T++V LLLE + + N+
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
G TPL A R HV+ V ALL + A G+TP+ +A G +V +++
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 64.7 bits (156), Expect = 7e-11
Identities = 40/126 (31%), Positives = 62/126 (49%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN + G TPL AS G + VR LL+ GA K+ + L A+ G+ I +L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
L+ I NG +P+ A +G+H+ CV LL A++ TP+ +A G+
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
Query: 214 KVQQVI 219
+V +V+
Sbjct: 352 RVAKVL 357
Score = 63.5 bits (153), Expect = 1e-10
Identities = 36/128 (28%), Positives = 65/128 (50%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+ P G+TPL A+ ++E R LL++G + + + + L LA+ G+ ++V LLL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 214
+ + N+ + +G TPL + HV + L+ G + GYTP+ +A G K
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 215 VQQVIENH 222
+ + + H
Sbjct: 716 LVKFLLQH 723
Score = 62.8 bits (151), Expect = 3e-10
Identities = 40/143 (27%), Positives = 69/143 (48%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L R V LD + + G +P+ A+ ++ VR LL++ A+
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+ + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E LL
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 190 GADLTTEADSGYTPMDLAVALGY 212
GA + +SG TP+ +A +G+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416
Score = 60.1 bits (144), Expect = 2e-09
Identities = 44/150 (29%), Positives = 65/150 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP S++K T L R L VN + TPL A+ G V+
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A+P++ + L +A+ G+ + V LLE++ G TPL A +
Sbjct: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAV 208
V+ E LL R A +G TP+ +AV
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Score = 59.3 bits (142), Expect = 3e-09
Identities = 36/129 (27%), Positives = 63/129 (48%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L AS G ++ V LL K+ +AL +A+ G ++V L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ ++N G TPL A + NH++ V+ LL GA+ + G+TP+ +A+ G+
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 214 KVQQVIENH 222
V + N+
Sbjct: 158 NVVAHLINY 166
Score = 57.8 bits (138), Expect = 8e-09
Identities = 41/144 (28%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Query: 76 QRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE 135
+RGN V + LD + + TPL A+ G + LL+ GA K
Sbjct: 248 RRGN-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Query: 136 SALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +GA +
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 196 EADSGYTPMDLAVALGYRKVQQVI 219
A +G+TP+ +A + +V +++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELL 390
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/156 (26%), Positives = 68/156 (43%)
Query: 60 SPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRF 119
SP + T L + N+V + L N +G TPL A+ G E V
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 120 LLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNH 179
LL A+ ++ K + L L + G+ + +L++ V ++ G TPL A +
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 713
Query: 180 VKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+K V+ LL AD+ + GY+P+ A G+ +
Sbjct: 714 IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 56.2 bits (134), Expect = 2e-08
Identities = 40/131 (30%), Positives = 63/131 (48%), Gaps = 4/131 (3%)
Query: 96 KPDER---GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
KP+ R GFTPL A + + LL+ GA + + + L +AS G+ IV
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
LL+R N+ + TPL A R H + + LL A + +A TP+ A +G+
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 213 -RKVQQVIENH 222
V+ ++EN+
Sbjct: 483 TNMVKLLLENN 493
Score = 56.2 bits (134), Expect = 2e-08
Identities = 35/94 (37%), Positives = 50/94 (53%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+V+ G+TPL AS +G I+ V+FLL+ AD + K S L A+ G+TDIV L
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
LL+ N +G TPL A R ++ + L
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 55.8 bits (133), Expect = 3e-08
Identities = 48/187 (25%), Positives = 74/187 (39%), Gaps = 29/187 (15%)
Query: 65 SLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 124
S K T L + N + + L+ N E GFTPL A G V L+ +G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 125 A-----------------------------DPHILAKERESALSLASTGGYTDIVGLLLE 155
+P +L+K + L +A+ ++ LLL
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 156 RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
R +N NG TPL A R +V V LL RGA + T+ TP+ A G+ ++
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 216 QQVIENH 222
+++ +H
Sbjct: 288 SEILLDH 294
Score = 55.5 bits (132), Expect = 4e-08
Identities = 35/107 (32%), Positives = 53/107 (49%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
GFTPL A+ + + + LL GA + + + L +AS G +V LLL+R I
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
+ TPL A R HV+ E LL GA + + +G +P+ +A
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Score = 54.7 bits (130), Expect = 7e-08
Identities = 43/156 (27%), Positives = 64/156 (41%)
Query: 67 KHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGAD 126
K T L + +V L+ D N + G TPL A ++ V+ LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 127 PHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
PH A + L +A+ ++ LL+ N G TPL A + H + V L
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 187 LARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L++ A+ SG TP+ L G+ V V+ H
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 53.5 bits (127), Expect = 2e-07
Identities = 48/166 (28%), Positives = 72/166 (43%), Gaps = 7/166 (4%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCD-NLVNKPDERGFTPLIWASAFGEI 114
A+ S QG + H L ++ E+ AL + + NL NK G TPL + G +
Sbjct: 628 ANAESVQGVTPLH---LAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 681
Query: 115 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
L++ G + + L +AS G +V LL+ D+N G +PL A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 175 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ H V LL GA + G TP+ +A LGY V V++
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 47.0 bits (110), Expect = 1e-05
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 7/139 (5%)
Query: 88 LDCDNLVNKPDER-------GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSL 140
LDC L+ + D TPL A+ G + LL+ GA P+ A + L +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Query: 141 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 200
A + ++ LLL+ I+ +G TPL A H+ V+ LL RGA
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 201 YTPMDLAVALGYRKVQQVI 219
TP+ +A G+ +V + +
Sbjct: 438 ETPLHMAARAGHTEVAKYL 456
Score = 43.5 bits (101), Expect = 2e-04
Identities = 27/92 (29%), Positives = 50/92 (54%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + ++V LLE
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARG 190
+ N+ +G TPL A++ H V L+ G
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 221
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Score = 35.4 bits (80), Expect = 0.043
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 132 KERESALSL--ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+E ++A S A+ G D L VDIN + NG L A + HVK V LL +
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 190 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L T G T + +A G +V + + N+
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 69.3 bits (168), Expect = 3e-12
Identities = 44/154 (28%), Positives = 72/154 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+ P +L T L + N V + L ++ E G TPL AS G + V+
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVK 421
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LL+ GA P++ + E+ L +A+ G+T++ LL+ +N + TPL A R
Sbjct: 422 NLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIG 481
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
H V+ LL A+ +G+TP+ +A G+
Sbjct: 482 HTNMVKLLLENNANPNLATTAGHTPLHIAAREGH 515
Score = 68.9 bits (167), Expect = 4e-12
Identities = 48/157 (30%), Positives = 73/157 (46%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
++P ++ T L R V + A L+ + ++GFTPL A+ +G++
Sbjct: 494 ANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAE 553
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A P+ K + L +A DIV LLL R + WNG TPL A + N
Sbjct: 554 LLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQN 613
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 614 QVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Score = 66.2 bits (160), Expect = 2e-11
Identities = 40/117 (34%), Positives = 64/117 (54%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
TPL A+ G E ++LL+ A + AK+ ++ L A+ G+T++V LLLE + + N+
Sbjct: 439 TPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNL 498
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 219
G TPL A R HV+ V ALL + A G+TP+ +A G +V +++
Sbjct: 499 ATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 64.7 bits (156), Expect = 7e-11
Identities = 40/126 (31%), Positives = 62/126 (49%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
VN + G TPL AS G + VR LL+ GA K+ + L A+ G+ I +L
Sbjct: 232 VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEIL 291
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
L+ I NG +P+ A +G+H+ CV LL A++ TP+ +A G+
Sbjct: 292 LDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHH 351
Query: 214 KVQQVI 219
+V +V+
Sbjct: 352 RVAKVL 357
Score = 63.5 bits (153), Expect = 1e-10
Identities = 36/128 (28%), Positives = 65/128 (50%)
Query: 95 NKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLL 154
+ P G+TPL A+ ++E R LL++G + + + + L LA+ G+ ++V LLL
Sbjct: 596 HSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLL 655
Query: 155 ERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 214
+ + N+ + +G TPL + HV + L+ G + GYTP+ +A G K
Sbjct: 656 SKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIK 715
Query: 215 VQQVIENH 222
+ + + H
Sbjct: 716 LVKFLLQH 723
Score = 62.8 bits (151), Expect = 3e-10
Identities = 40/143 (27%), Positives = 69/143 (48%)
Query: 70 TTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 129
T L R V LD + + G +P+ A+ ++ VR LL++ A+
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 130 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+ + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E LL
Sbjct: 334 ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKT 393
Query: 190 GADLTTEADSGYTPMDLAVALGY 212
GA + +SG TP+ +A +G+
Sbjct: 394 GASIDAVTESGLTPLHVASFMGH 416
Score = 60.1 bits (144), Expect = 2e-09
Identities = 44/150 (29%), Positives = 65/150 (43%)
Query: 59 SSPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVR 118
+SP S++K T L R L VN + TPL A+ G V+
Sbjct: 428 ASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVK 487
Query: 119 FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 178
LLE A+P++ + L +A+ G+ + V LLE++ G TPL A +
Sbjct: 488 LLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYG 547
Query: 179 HVKCVEALLARGADLTTEADSGYTPMDLAV 208
V+ E LL R A +G TP+ +AV
Sbjct: 548 KVRVAELLLERDAHPNAAGKNGLTPLHVAV 577
Score = 59.3 bits (142), Expect = 3e-09
Identities = 36/129 (27%), Positives = 63/129 (48%)
Query: 94 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 153
+N ++ G L AS G ++ V LL K+ +AL +A+ G ++V L
Sbjct: 38 INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVREL 97
Query: 154 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 213
+ ++N G TPL A + NH++ V+ LL GA+ + G+TP+ +A+ G+
Sbjct: 98 VNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHE 157
Query: 214 KVQQVIENH 222
V + N+
Sbjct: 158 NVVAHLINY 166
Score = 57.8 bits (138), Expect = 8e-09
Identities = 41/144 (28%), Positives = 69/144 (47%), Gaps = 1/144 (0%)
Query: 76 QRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE 135
+RGN V + LD + + TPL A+ G + LL+ GA K
Sbjct: 248 RRGN-VIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGL 306
Query: 136 SALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 195
S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +GA +
Sbjct: 307 SPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNS 366
Query: 196 EADSGYTPMDLAVALGYRKVQQVI 219
A +G+TP+ +A + +V +++
Sbjct: 367 RALNGFTPLHIACKKNHVRVMELL 390
Score = 56.6 bits (135), Expect = 2e-08
Identities = 41/156 (26%), Positives = 68/156 (43%)
Query: 60 SPQGSSLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRF 119
SP + T L + N+V + L N +G TPL A+ G E V
Sbjct: 594 SPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVAL 653
Query: 120 LLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNH 179
LL A+ ++ K + L L + G+ + +L++ V ++ G TPL A +
Sbjct: 654 LLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGN 713
Query: 180 VKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
+K V+ LL AD+ + GY+P+ A G+ +
Sbjct: 714 IKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 56.2 bits (134), Expect = 2e-08
Identities = 40/131 (30%), Positives = 63/131 (48%), Gaps = 4/131 (3%)
Query: 96 KPDER---GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
KP+ R GFTPL A + + LL+ GA + + + L +AS G+ IV
Sbjct: 363 KPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKN 422
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGY 212
LL+R N+ + TPL A R H + + LL A + +A TP+ A +G+
Sbjct: 423 LLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGH 482
Query: 213 -RKVQQVIENH 222
V+ ++EN+
Sbjct: 483 TNMVKLLLENN 493
Score = 56.2 bits (134), Expect = 2e-08
Identities = 35/94 (37%), Positives = 50/94 (53%)
Query: 93 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 152
+V+ G+TPL AS +G I+ V+FLL+ AD + K S L A+ G+TDIV L
Sbjct: 693 MVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTL 752
Query: 153 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
LL+ N +G TPL A R ++ + L
Sbjct: 753 LLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 55.8 bits (133), Expect = 3e-08
Identities = 48/187 (25%), Positives = 74/187 (39%), Gaps = 29/187 (15%)
Query: 65 SLKHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 124
S K T L + N + + L+ N E GFTPL A G V L+ +G
Sbjct: 108 SQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Query: 125 A-----------------------------DPHILAKERESALSLASTGGYTDIVGLLLE 155
+P +L+K + L +A+ ++ LLL
Sbjct: 168 TKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLN 227
Query: 156 RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 215
R +N NG TPL A R +V V LL RGA + T+ TP+ A G+ ++
Sbjct: 228 RGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRI 287
Query: 216 QQVIENH 222
+++ +H
Sbjct: 288 SEILLDH 294
Score = 55.5 bits (132), Expect = 4e-08
Identities = 35/107 (32%), Positives = 53/107 (49%)
Query: 101 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 160
GFTPL A+ + + + LL GA + + + L +AS G +V LLL+R I
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 161 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 207
+ TPL A R HV+ E LL GA + + +G +P+ +A
Sbjct: 266 ETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMA 312
Score = 54.7 bits (130), Expect = 7e-08
Identities = 43/156 (27%), Positives = 64/156 (41%)
Query: 67 KHSTTLTNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGAD 126
K T L + +V L+ D N + G TPL A ++ V+ LL G
Sbjct: 535 KGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGS 594
Query: 127 PHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 186
PH A + L +A+ ++ LL+ N G TPL A + H + V L
Sbjct: 595 PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALL 654
Query: 187 LARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L++ A+ SG TP+ L G+ V V+ H
Sbjct: 655 LSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 53.5 bits (127), Expect = 2e-07
Identities = 48/166 (28%), Positives = 72/166 (43%), Gaps = 7/166 (4%)
Query: 56 ASVSSPQGSSLKHSTTLTNRQRGNEVSALPATLDCD-NLVNKPDERGFTPLIWASAFGEI 114
A+ S QG + H L ++ E+ AL + + NL NK G TPL + G +
Sbjct: 628 ANAESVQGVTPLH---LAAQEGHAEMVALLLSKQANGNLGNKS---GLTPLHLVAQEGHV 681
Query: 115 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 174
L++ G + + L +AS G +V LL+ D+N G +PL A
Sbjct: 682 PVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 175 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 220
+ H V LL GA + G TP+ +A LGY V V++
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 47.0 bits (110), Expect = 1e-05
Identities = 39/139 (28%), Positives = 61/139 (43%), Gaps = 7/139 (5%)
Query: 88 LDCDNLVNKPDER-------GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSL 140
LDC L+ + D TPL A+ G + LL+ GA P+ A + L +
Sbjct: 318 LDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHI 377
Query: 141 ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSG 200
A + ++ LLL+ I+ +G TPL A H+ V+ LL RGA
Sbjct: 378 ACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKV 437
Query: 201 YTPMDLAVALGYRKVQQVI 219
TP+ +A G+ +V + +
Sbjct: 438 ETPLHMAARAGHTEVAKYL 456
Score = 43.5 bits (101), Expect = 2e-04
Identities = 27/92 (29%), Positives = 50/92 (54%)
Query: 99 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 158
++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + ++V LLE
Sbjct: 76 KKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGA 135
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARG 190
+ N+ +G TPL A++ H V L+ G
Sbjct: 136 NQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 103 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 162
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 163 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 221
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Score = 35.4 bits (80), Expect = 0.043
Identities = 29/93 (31%), Positives = 42/93 (45%), Gaps = 2/93 (2%)
Query: 132 KERESALSL--ASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 189
+E ++A S A+ G D L VDIN + NG L A + HVK V LL +
Sbjct: 8 READAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHK 67
Query: 190 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 222
L T G T + +A G +V + + N+
Sbjct: 68 EIILETTTKKGNTALHIAALAGQDEVVRELVNY 100
>gi|62420875 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 68.9 bits (167), Expect = 4e-12
Identities = 45/137 (32%), Positives = 71/137 (51%)
Query: 73 TNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 132
T + GN V+ + +N +N+ D+ GF+PL WA G V L+ GA +++ +
Sbjct: 6 TQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNR 65
Query: 133 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 192
++ L LA++ G+ DIV LL+ DIN + +G PL YA + E L+A GA
Sbjct: 66 GDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGAL 125
Query: 193 LTTEADSGYTPMDLAVA 209
++ G P+D A A
Sbjct: 126 VSICNKYGEMPVDKAKA 142
Score = 36.2 bits (82), Expect = 0.025
Identities = 21/59 (35%), Positives = 31/59 (52%)
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 217
D+N D +G +PL +A R VE L+ RGA + TP+ LA + G+R + Q
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84
>gi|62420873 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 68.9 bits (167), Expect = 4e-12
Identities = 45/137 (32%), Positives = 71/137 (51%)
Query: 73 TNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 132
T + GN V+ + +N +N+ D+ GF+PL WA G V L+ GA +++ +
Sbjct: 6 TQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNR 65
Query: 133 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 192
++ L LA++ G+ DIV LL+ DIN + +G PL YA + E L+A GA
Sbjct: 66 GDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGAL 125
Query: 193 LTTEADSGYTPMDLAVA 209
++ G P+D A A
Sbjct: 126 VSICNKYGEMPVDKAKA 142
Score = 36.2 bits (82), Expect = 0.025
Identities = 21/59 (35%), Positives = 31/59 (52%)
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 217
D+N D +G +PL +A R VE L+ RGA + TP+ LA + G+R + Q
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84
>gi|4758606 integrin-linked kinase [Homo sapiens]
Length = 452
Score = 68.9 bits (167), Expect = 4e-12
Identities = 45/137 (32%), Positives = 71/137 (51%)
Query: 73 TNRQRGNEVSALPATLDCDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 132
T + GN V+ + +N +N+ D+ GF+PL WA G V L+ GA +++ +
Sbjct: 6 TQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNR 65
Query: 133 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 192
++ L LA++ G+ DIV LL+ DIN + +G PL YA + E L+A GA
Sbjct: 66 GDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGAL 125
Query: 193 LTTEADSGYTPMDLAVA 209
++ G P+D A A
Sbjct: 126 VSICNKYGEMPVDKAKA 142
Score = 36.2 bits (82), Expect = 0.025
Identities = 21/59 (35%), Positives = 31/59 (52%)
Query: 159 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 217
D+N D +G +PL +A R VE L+ RGA + TP+ LA + G+R + Q
Sbjct: 26 DLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQ 84
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.389
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,038,839
Number of Sequences: 37866
Number of extensions: 488171
Number of successful extensions: 3534
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 336
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 1379
Number of HSP's gapped (non-prelim): 1564
length of query: 237
length of database: 18,247,518
effective HSP length: 99
effective length of query: 138
effective length of database: 14,498,784
effective search space: 2000832192
effective search space used: 2000832192
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.