Search of human proteins with 197333744

Search of human proteins with 197333744

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
         (502 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]       1001   0.0  
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          991   0.0  
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   716   0.0  
gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         603   e-172
gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]         603   e-172
gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]         596   e-170
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    375   e-104
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]                   353   3e-97
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   339   4e-93
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   326   3e-89
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             318   7e-87
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        317   1e-86
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           316   3e-86
gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]       251   1e-66
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...   239   3e-63
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...   239   3e-63
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...   239   3e-63
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...   239   3e-63
gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isof...   239   3e-63
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...   239   3e-63
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]    237   2e-62
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]    237   2e-62
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   228   7e-60
gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]      226   5e-59
gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]                   218   1e-56
gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]    217   2e-56
gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]    217   2e-56
gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2...   215   7e-56
gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1...   215   7e-56
gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]                 209   4e-54

>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score = 1001 bits (2589), Expect = 0.0
 Identities = 502/502 (100%), Positives = 502/502 (100%)

Query: 1   MQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPG 60
           MQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPG
Sbjct: 1   MQSEIAMDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPG 60

Query: 61  ELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDI 120
           ELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDI
Sbjct: 61  ELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDI 120

Query: 121 NKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEG 180
           NKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEG
Sbjct: 121 NKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEG 180

Query: 181 TYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEK 240
           TYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEK
Sbjct: 181 TYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEK 240

Query: 241 SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLI 300
           SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLI
Sbjct: 241 SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLI 300

Query: 301 NERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYE 360
           NERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYE
Sbjct: 301 NERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYE 360

Query: 361 MATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPR 420
           MATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPR
Sbjct: 361 MATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPR 420

Query: 421 LDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEA 480
           LDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEA
Sbjct: 421 LDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEA 480

Query: 481 SLRSSSMPDSGRPAFRVVDTEF 502
           SLRSSSMPDSGRPAFRVVDTEF
Sbjct: 481 SLRSSSMPDSGRPAFRVVDTEF 502


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  991 bits (2562), Expect = 0.0
 Identities = 496/496 (100%), Positives = 496/496 (100%)

Query: 7   MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 66
           MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR
Sbjct: 1   MDRMKKIKRQLSMTLRGGRGIDKTNGAPEQIGLDESGGGGGSDPGEAPTRAAPGELRSAR 60

Query: 67  GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 126
           GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL
Sbjct: 61  GPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSL 120

Query: 127 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 186
           PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY
Sbjct: 121 PADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVY 180

Query: 187 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 246
           KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF
Sbjct: 181 KGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVF 240

Query: 247 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 306
           EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL
Sbjct: 241 EYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGEL 300

Query: 307 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 366
           KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP
Sbjct: 301 KLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRP 360

Query: 367 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 426
           LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA
Sbjct: 361 LFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGA 420

Query: 427 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS
Sbjct: 421 DLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 480

Query: 487 MPDSGRPAFRVVDTEF 502
           MPDSGRPAFRVVDTEF
Sbjct: 481 MPDSGRPAFRVVDTEF 496


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  716 bits (1849), Expect = 0.0
 Identities = 356/512 (69%), Positives = 424/512 (82%), Gaps = 30/512 (5%)

Query: 10  MKKIKRQLSMTLRGGRGIDKT-NGAPEQIGLDESGGG-------GGSDPG---------- 51
           MKK KR+LS+TLRG + ID++ +   EQ+ ++E+           G  P           
Sbjct: 1   MKKFKRRLSLTLRGSQTIDESLSELAEQMTIEENSSKDNEPIVKNGRPPTSHSMHSFLHQ 60

Query: 52  ------EAPTRAAPGELRSARGPLSSAP------EIVHEDLKMGSDGESDQASATSSDEV 99
                 + P R     +  + G   + P      +IVHE+LKMGSDGESDQAS TSSDEV
Sbjct: 61  YTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLKMGSDGESDQASGTSSDEV 120

Query: 100 QSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVS 159
           QSP  V +RN   R+IS ED+NKRLSLPADIR+P+GYLEKL +NSP FD+P+SRR RR S
Sbjct: 121 QSPTGVCLRNRIHRRISMEDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMSRRSRRAS 180

Query: 160 LSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVS 219
           LSEIGFGK+ETYIKL+KLGEGTYATVYKG+SKLT+NLVALKEIRLEHEEGAPCTAIREVS
Sbjct: 181 LSEIGFGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVS 240

Query: 220 LLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRG 279
           LLKDLKHANIVTLHDI+HT+KSLTLVFEYLDKDLKQY+DDCGNI++MHNVKLFL+Q+LRG
Sbjct: 241 LLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDCGNIMSMHNVKLFLYQILRG 300

Query: 280 LAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL 339
           LAYCHR+KVLHRDLKPQNLLINE+GELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+L
Sbjct: 301 LAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

Query: 340 LGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNE 399
           LGS++YSTQIDMWGVGCIF+EMA+GRPLFPGSTVE++LH IFR+LGTP++ETWPGI SNE
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPSQETWPGISSNE 420

Query: 400 EFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERI 459
           EFK YN+PKY+ + L++HAPRLDS+G +L+TK LQ+E + R+SAE+AMKH +F SLG RI
Sbjct: 421 EFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKHVYFRSLGPRI 480

Query: 460 HKLPDTTSIFALKEIQLQKEASLRSSSMPDSG 491
           H LP++ SIF+LKEIQLQK+   R+SS P++G
Sbjct: 481 HALPESVSIFSLKEIQLQKDPGFRNSSYPETG 512


>gi|47078231 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  603 bits (1555), Expect = e-172
 Identities = 297/424 (70%), Positives = 351/424 (82%), Gaps = 8/424 (1%)

Query: 77  HEDLKMGSDG-----ESDQASATSSDEVQ---SPVRVRMRNHPPRKISTEDINKRLSLPA 128
           +E+L++G  G     E    S T S E     SP     R    R+ S ED++KRLSLP 
Sbjct: 42  NENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPM 101

Query: 129 DIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKG 188
           DIRLP+ +L+KL + SP   KPLSR  RR SLS+IGFGKLETY+KLDKLGEGTYATV+KG
Sbjct: 102 DIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKG 161

Query: 189 KSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEY 248
           +SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD+IHT++SLTLVFEY
Sbjct: 162 RSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEY 221

Query: 249 LDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKL 308
           LD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLKPQNLLINERGELKL
Sbjct: 222 LDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKL 281

Query: 309 ADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF 368
           ADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGVGCI YEMATGRPLF
Sbjct: 282 ADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLF 341

Query: 369 PGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADL 428
           PGSTV+E+LH IFR+LGTPTEETWPG+ +  EF+TY++P Y  + L++HAPRLD+DG  L
Sbjct: 342 PGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHL 401

Query: 429 LTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMP 488
           L+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEIQLQK+   R  +  
Sbjct: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461

Query: 489 DSGR 492
             GR
Sbjct: 462 QPGR 465


>gi|47078229 PCTAIRE protein kinase 3 isoform b [Homo sapiens]
          Length = 474

 Score =  603 bits (1555), Expect = e-172
 Identities = 297/424 (70%), Positives = 351/424 (82%), Gaps = 8/424 (1%)

Query: 77  HEDLKMGSDG-----ESDQASATSSDEVQ---SPVRVRMRNHPPRKISTEDINKRLSLPA 128
           +E+L++G  G     E    S T S E     SP     R    R+ S ED++KRLSLP 
Sbjct: 42  NENLQLGPLGRDPPQECSTFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPM 101

Query: 129 DIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKG 188
           DIRLP+ +L+KL + SP   KPLSR  RR SLS+IGFGKLETY+KLDKLGEGTYATV+KG
Sbjct: 102 DIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKG 161

Query: 189 KSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEY 248
           +SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD+IHT++SLTLVFEY
Sbjct: 162 RSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEY 221

Query: 249 LDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKL 308
           LD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLKPQNLLINERGELKL
Sbjct: 222 LDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKL 281

Query: 309 ADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLF 368
           ADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGVGCI YEMATGRPLF
Sbjct: 282 ADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLF 341

Query: 369 PGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADL 428
           PGSTV+E+LH IFR+LGTPTEETWPG+ +  EF+TY++P Y  + L++HAPRLD+DG  L
Sbjct: 342 PGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHL 401

Query: 429 LTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSMP 488
           L+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEIQLQK+   R  +  
Sbjct: 402 LSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQ 461

Query: 489 DSGR 492
             GR
Sbjct: 462 QPGR 465


>gi|47078233 PCTAIRE protein kinase 3 isoform a [Homo sapiens]
          Length = 504

 Score =  596 bits (1536), Expect = e-170
 Identities = 304/498 (61%), Positives = 372/498 (74%), Gaps = 17/498 (3%)

Query: 7   MDRMKKIKRQLSMTLRGGRGIDKT------------NGAPEQIGLDESGGGGGSDPGEAP 54
           M++MK  KR+ S+++     I+++            N   E + L    G  G DP +  
Sbjct: 3   MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQL----GPLGRDPPQEC 58

Query: 55  TRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRK 114
           +  +P +     G LS   +      +     E  +AS     +V       +       
Sbjct: 59  STFSPTDSGEEPGQLSPGVQFQRRQNQRRFSMEV-RASGALPRQVAGCTHKGVHRRAAAL 117

Query: 115 ISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKL 174
               D++KRLSLP DIRLP+ +L+KL + SP   KPLSR  RR SLS+IGFGKLETY+KL
Sbjct: 118 QPDFDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLSRMSRRASLSDIGFGKLETYVKL 177

Query: 175 DKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHD 234
           DKLGEGTYATV+KG+SKLT+NLVALKEIRLEHEEGAPCTAIREVSLLK+LKHANIVTLHD
Sbjct: 178 DKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHD 237

Query: 235 IIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLK 294
           +IHT++SLTLVFEYLD DLKQYLD CGN+++MHNVK+F+FQLLRGLAYCH +K+LHRDLK
Sbjct: 238 LIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLK 297

Query: 295 PQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGV 354
           PQNLLINERGELKLADFGLARAKS+PTKTYSNEVVTLWYRPPD+LLGST+YST IDMWGV
Sbjct: 298 PQNLLINERGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGV 357

Query: 355 GCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEAL 414
           GCI YEMATGRPLFPGSTV+E+LH IFR+LGTPTEETWPG+ +  EF+TY++P Y  + L
Sbjct: 358 GCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPL 417

Query: 415 LSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEI 474
           ++HAPRLD+DG  LL+ LL +E ++R+SAE A+ H +F SLGER+H+L DT SIF+LKEI
Sbjct: 418 INHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEI 477

Query: 475 QLQKEASLRSSSMPDSGR 492
           QLQK+   R  +    GR
Sbjct: 478 QLQKDPGYRGLAFQQPGR 495


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  375 bits (963), Expect = e-104
 Identities = 192/319 (60%), Positives = 239/319 (74%), Gaps = 3/319 (0%)

Query: 165 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 224
           FGK ++Y KL+KLGEG+YATVYKGKSK+   LVALK IRL+ EEG P TAIRE SLLK L
Sbjct: 111 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGL 170

Query: 225 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 284
           KHANIV LHDIIHT+++LTLVFEY+  DL QY+D     ++  NVKLFLFQLLRGL+Y H
Sbjct: 171 KHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIH 230

Query: 285 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 344
           ++ +LHRDLKPQNLLI++ GELKLADFGLARAKS+P+ TYSNEVVTLWYRPPD+LLGST+
Sbjct: 231 QRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTE 290

Query: 345 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGILSNEEFKT 403
           YST +DMWGVGCIF EM  G   FPG   +++QL  IF +LGTP E+TWPG+ S   FK 
Sbjct: 291 YSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKP 350

Query: 404 YNYPKYRAEALLSHAPRLD--SDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 461
             +  Y ++ L     +L   +   DL +KLLQ   +NR+SA+ A+ H +F  L  R+ +
Sbjct: 351 ERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWE 410

Query: 462 LPDTTSIFALKEIQLQKEA 480
           L D +SIF +  ++LQ EA
Sbjct: 411 LTDMSSIFTVPNVRLQPEA 429


>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
          Length = 384

 Score =  353 bits (905), Expect = 3e-97
 Identities = 180/333 (54%), Positives = 240/333 (72%), Gaps = 3/333 (0%)

Query: 165 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 224
           FG   +Y+ L+KLGEG+YATVYKG S++   LVALK I +  EEG P TAIRE SLLK L
Sbjct: 46  FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPFTAIREASLLKGL 105

Query: 225 KHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCH 284
           KHANIV LHDIIHT+++LT VFEY+  DL QY+      ++ HNV+LF+FQLLRGLAY H
Sbjct: 106 KHANIVLLHDIIHTKETLTFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIH 165

Query: 285 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 344
            Q VLHRDLKPQNLLI+  GELKLADFGLARAKSIP++TYS+EVVTLWYRPPD LLG+T+
Sbjct: 166 HQHVLHRDLKPQNLLISHLGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATE 225

Query: 345 YSTQIDMWGVGCIFYEMATGRPLFPG-STVEEQLHFIFRILGTPTEETWPGI--LSNEEF 401
           YS+++D+WG GCIF EM  G+PLFPG S + EQL  I+ +LG PTE+TWPG+  L N   
Sbjct: 226 YSSELDIWGAGCIFIEMFQGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNP 285

Query: 402 KTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHK 461
           + +  P  R+  ++ +      +  DL +++L+   R+R+SA++A+ H +F +L  ++++
Sbjct: 286 EWFPLPTPRSLHVVWNRLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQ 345

Query: 462 LPDTTSIFALKEIQLQKEASLRSSSMPDSGRPA 494
           LPD  S+F +  ++L+ E     +S      PA
Sbjct: 346 LPDEESLFTVSGVRLKPEMCDLLASYQKGHHPA 378


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  339 bits (869), Expect = 4e-93
 Identities = 167/288 (57%), Positives = 216/288 (75%), Gaps = 5/288 (1%)

Query: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 226
           ++ Y KL+K+GEGTY TV+K K++ T  +VALK +RL+ + EG P +A+RE+ LLK+LKH
Sbjct: 1   MQKYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH 60

Query: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYCHRQ 286
            NIV LHD++H++K LTLVFE+ D+DLK+Y D C   ++   VK FLFQLL+GL +CH +
Sbjct: 61  KNIVRLHDVLHSDKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120

Query: 287 KVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYS 346
            VLHRDLKPQNLLIN  GELKLADFGLARA  IP + YS EVVTLWYRPPD+L G+  YS
Sbjct: 121 NVLHRDLKPQNLLINRNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLYS 180

Query: 347 TQIDMWGVGCIFYEMA-TGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 405
           T IDMW  GCIF E+A  GRPLFPG+ V++QL  IFR+LGTPTEE WP +    ++K   
Sbjct: 181 TSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKLPDYKP-- 238

Query: 406 YPKYRA-EALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
           YP Y A  +L++  P+L++ G DLL  LL+     RISAE+A++HP+F
Sbjct: 239 YPMYPATTSLVNVVPKLNATGRDLLQNLLKCNPVQRISAEEALQHPYF 286


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  326 bits (835), Expect = 3e-89
 Identities = 157/289 (54%), Positives = 219/289 (75%), Gaps = 3/289 (1%)

Query: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 226
           ++ + K++K+GEGTY  VYK K++ T  LVALK+IRL+ E EG P TAIRE+SLLK+LKH
Sbjct: 1   MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKH 60

Query: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC-GNIINMHNVKLFLFQLLRGLAYCHR 285
            NIV L D++H E+ L LVFE+L +DLK+Y+D   G+ + +H +K +LFQLL+G+++CH 
Sbjct: 61  PNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHS 120

Query: 286 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 345
            +V+HRDLKPQNLLINE G +KLADFGLARA  +P +TY++EVVTLWYR P+ILLGS  Y
Sbjct: 121 HRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFY 180

Query: 346 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 405
           +T +D+W +GCIF EM T + LFPG +  +QL  IFR+LGTP+E+TWPG+    ++K  +
Sbjct: 181 TTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKG-S 239

Query: 406 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLS 454
           +PK+  + L    P L+ +G DLL +LLQ++   RI+A+ A+ HP+F S
Sbjct: 240 FPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSS 288


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  318 bits (815), Expect = 7e-87
 Identities = 154/298 (51%), Positives = 216/298 (72%), Gaps = 4/298 (1%)

Query: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 226
           +E Y K++K+GEGTY  VYKG+ K T  +VA+K+IRLE  EEG P TAIRE+SLLK+L+H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC--GNIINMHNVKLFLFQLLRGLAYCH 284
            NIV+L D++  +  L L+FE+L  DLK+YLD    G  ++   VK +L+Q+L+G+ +CH
Sbjct: 61  PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120

Query: 285 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 344
            ++VLHRDLKPQNLLI+++G +KLADFGLARA  IP + Y++EVVTLWYR P++LLGS  
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR 180

Query: 345 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 404
           YST +D+W +G IF E+AT +PLF G +  +QL  IFR LGTP  E WP + S +++K  
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239

Query: 405 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 462
            +PK++  +L SH   LD +G DLL+K+L ++   RIS + A+ HP+F  L  +I K+
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  317 bits (813), Expect = 1e-86
 Identities = 159/287 (55%), Positives = 208/287 (72%), Gaps = 3/287 (1%)

Query: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 226
           +E + K++K+GEGTY  VYK ++KLT  +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCHR 285
            NIV L D+IHTE  L LVFE+L +DLK+++D      I +  +K +LFQLL+GLA+CH 
Sbjct: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120

Query: 286 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 345
            +VLHRDLKPQNLLIN  G +KLADFGLARA  +P +TY++EVVTLWYR P+ILLG   Y
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY 180

Query: 346 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 405
           ST +D+W +GCIF EM T R LFPG +  +QL  IFR LGTP E  WPG+ S  ++K  +
Sbjct: 181 STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 239

Query: 406 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
           +PK+  +      P LD DG  LL+++L ++   RISA+ A+ HPFF
Sbjct: 240 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  316 bits (810), Expect = 3e-86
 Identities = 152/298 (51%), Positives = 215/298 (72%), Gaps = 4/298 (1%)

Query: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLE-HEEGAPCTAIREVSLLKDLKH 226
           +E Y K++K+GEGTY  VYKG+ K T  +VA+K+IRLE  EEG P TAIRE+SLLK+L+H
Sbjct: 1   MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH 60

Query: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC--GNIINMHNVKLFLFQLLRGLAYCH 284
            NIV+L D++  +  L L+FE+L  DLK+YLD    G  ++   VK +L+Q+L+G+ +CH
Sbjct: 61  PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH 120

Query: 285 RQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTD 344
            ++VLHRDLKPQNLLI+++G +KLADFGLARA  IP + Y++E +TLWYR P++LLGS  
Sbjct: 121 SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLLGSAR 180

Query: 345 YSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTY 404
           YST +D+W +G IF E+AT +PLF G +  +QL  IFR LGTP  E WP + S +++K  
Sbjct: 181 YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKN- 239

Query: 405 NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKL 462
            +PK++  +L SH   LD +G DLL+K+L ++   RIS + A+ HP+F  L  +I K+
Sbjct: 240 TFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM 297


>gi|166362719 cyclin-dependent kinase 2 isoform 2 [Homo sapiens]
          Length = 264

 Score =  251 bits (641), Expect = 1e-66
 Identities = 137/287 (47%), Positives = 182/287 (63%), Gaps = 37/287 (12%)

Query: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 226
           +E + K++K+GEGTY  VYK ++KLT  +VALK+IRL+ E EG P TAIRE+SLLK+L H
Sbjct: 1   MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH 60

Query: 227 ANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLLRGLAYCHR 285
            NIV L D+IHTE  L LVFE+L +DLK+++D      I +  +K +LFQLL+GLA+CH 
Sbjct: 61  PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS 120

Query: 286 QKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDY 345
            +VLHRDLKPQNLLIN  G +KLADFGLARA  +P +TY++EV                 
Sbjct: 121 HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEV----------------- 163

Query: 346 STQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKTYN 405
                            T R LFPG +  +QL  IFR LGTP E  WPG+ S  ++K  +
Sbjct: 164 -----------------TRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKP-S 205

Query: 406 YPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
           +PK+  +      P LD DG  LL+++L ++   RISA+ A+ HPFF
Sbjct: 206 FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 252


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score =  239 bits (611), Expect = 3e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 274 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 333

Query: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 334 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 392

Query: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 393 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 450

Query: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 451 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 510

Query: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 511 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 570

Query: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 571 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 630

Query: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 631 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 690

Query: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 691 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 728


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score =  239 bits (611), Expect = 3e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 342

Query: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 343 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 401

Query: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 402 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 459

Query: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 460 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 519

Query: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 520 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 579

Query: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 580 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 639

Query: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 640 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 699

Query: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 700 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 737


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score =  239 bits (611), Expect = 3e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 251 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 310

Query: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 311 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 369

Query: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 370 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 427

Query: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 428 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 487

Query: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 488 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 547

Query: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 548 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 607

Query: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 608 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 667

Query: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 668 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 705


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score =  239 bits (611), Expect = 3e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 240 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 299

Query: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 300 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 358

Query: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 359 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 416

Query: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 417 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 476

Query: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 477 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 536

Query: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 537 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 596

Query: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 597 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 656

Query: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 657 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 694


>gi|16332360 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           3 [Homo sapiens]
          Length = 526

 Score =  239 bits (611), Expect = 3e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 29  ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 88

Query: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 89  SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 147

Query: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 148 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 205

Query: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 206 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 265

Query: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 266 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 325

Query: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 326 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 385

Query: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 386 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 445

Query: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 446 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 483


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score =  239 bits (611), Expect = 3e-63
 Identities = 159/463 (34%), Positives = 236/463 (50%), Gaps = 25/463 (5%)

Query: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 285 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 344

Query: 101 SPVRVRMR-NH----PPRKIS-----TEDINKRLS--LPADIRLPEG-YLEKLTLNSPIF 147
           S    R   NH    P  +       +E+  + +    P    L EG Y+      SPI 
Sbjct: 345 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPI- 403

Query: 148 DKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE 207
              L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E
Sbjct: 404 --ELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKE 461

Query: 208 -EGAPCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNII 264
            EG P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++      
Sbjct: 462 KEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPF 521

Query: 265 NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTY 324
               VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y
Sbjct: 522 LPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAY 581

Query: 325 SNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRIL 384
           +  VVTLWYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG +  +Q++ +F+ L
Sbjct: 582 TPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDL 641

Query: 385 GTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISA 443
           GTP+E+ WPG       K   + ++    L      L SD G DL+ K L +    RISA
Sbjct: 642 GTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISA 701

Query: 444 EDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           ED +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 702 EDGLKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 739


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score =  237 bits (604), Expect = 2e-62
 Identities = 156/460 (33%), Positives = 235/460 (51%), Gaps = 19/460 (4%)

Query: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 273 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 332

Query: 101 SPVRVRMRNHPPRKI--STEDINKRLSLPADIRLPEGYLEK--LTLNSPIFDKP------ 150
           S    R   +    +  S  D +   S  A+  + EG  +   LT    + D P      
Sbjct: 333 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 392

Query: 151 LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EG 209
           L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E EG
Sbjct: 393 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 452

Query: 210 APCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMH 267
            P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++         
Sbjct: 453 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 512

Query: 268 NVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE 327
            VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  
Sbjct: 513 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 572

Query: 328 VVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTP 387
           VVT WYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG++  +Q++ +F+ LGTP
Sbjct: 573 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 632

Query: 388 TEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISAEDA 446
           +E+ WPG       K   + ++    L      L SD G DL+ K L +    RISAED 
Sbjct: 633 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 692

Query: 447 MKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 693 LKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 727


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score =  237 bits (604), Expect = 2e-62
 Identities = 156/460 (33%), Positives = 235/460 (51%), Gaps = 19/460 (4%)

Query: 41  ESGGGGGSDPGEAPTRAAPGELRSARGPLSSAPEIVHEDLKMGSDGESDQASATSSDEVQ 100
           ESG G   +  E       G             E   E+    S+  S+Q++   S+E  
Sbjct: 283 ESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEM 342

Query: 101 SPVRVRMRNHPPRKI--STEDINKRLSLPADIRLPEGYLEK--LTLNSPIFDKP------ 150
           S    R   +    +  S  D +   S  A+  + EG  +   LT    + D P      
Sbjct: 343 SEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALLPIE 402

Query: 151 LSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EG 209
           L + L +   +  G   +E +  L+++ EGTY  VY+ K K TD +VALK +++E E EG
Sbjct: 403 LKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEG 462

Query: 210 APCTAIREVSLLKDLKHANIVTLHDII--HTEKSLTLVFEYLDKDLKQYLDDCGNIINMH 267
            P T++RE++ +   +H NIVT+ +I+       + +V  Y++ DLK  ++         
Sbjct: 463 FPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPG 522

Query: 268 NVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNE 327
            VK  + QLLRG+ + H   +LHRDLK  NLL++  G LK+ DFGLAR    P K Y+  
Sbjct: 523 EVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPV 582

Query: 328 VVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTP 387
           VVT WYR P++LLG+ +YST +DMW VGCIF E+ T +PLFPG++  +Q++ +F+ LGTP
Sbjct: 583 VVTQWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGNSEIDQINKVFKELGTP 642

Query: 388 TEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSD-GADLLTKLLQFEGRNRISAEDA 446
           +E+ WPG       K   + ++    L      L SD G DL+ K L +    RISAED 
Sbjct: 643 SEKIWPGYSELPVVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDG 702

Query: 447 MKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSS 486
           +KH +F     R   LP   S+F     + +++   R +S
Sbjct: 703 LKHEYF-----RETPLPIDPSMFPTWPAKSEQQRVKRGTS 737


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  228 bits (582), Expect = 7e-60
 Identities = 119/291 (40%), Positives = 180/291 (61%), Gaps = 8/291 (2%)

Query: 167 KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEH----EEGAPCTAIREVSLLK 222
           + + Y KLD LGEG +ATVYK + K T+ +VA+K+I+L H    ++G   TA+RE+ LL+
Sbjct: 8   RAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQ 67

Query: 223 DLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAY 282
           +L H NI+ L D    + +++LVF++++ DL+  + D   ++   ++K ++   L+GL Y
Sbjct: 68  ELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 283 CHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGS 342
            H+  +LHRDLKP NLL++E G LKLADFGLA++   P + Y+++VVT WYR P++L G+
Sbjct: 128 LHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGA 187

Query: 343 TDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFK 402
             Y   +DMW VGCI  E+    P  PG +  +QL  IF  LGTPTEE WP + S  ++ 
Sbjct: 188 RMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYV 247

Query: 403 TY-NYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
           T+ ++P      + S A     D  DL+  L  F    RI+A  A+K  +F
Sbjct: 248 TFKSFPGIPLHHIFSAA---GDDLLDLIQGLFLFNPCARITATQALKMKYF 295


>gi|148596926 cyclin-dependent kinase 10 isoform a [Homo sapiens]
          Length = 360

 Score =  226 bits (575), Expect = 5e-59
 Identities = 118/289 (40%), Positives = 177/289 (61%), Gaps = 5/289 (1%)

Query: 168 LETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKH 226
           ++ + KL+++GEGTY  VY+ +   TD +VALK++R++ E +G P +++RE++LL  L+H
Sbjct: 36  VKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRH 95

Query: 227 ANIVTLHDII---HTEKSLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLLRGLAYC 283
            NIV L +++   H E S+ LV  Y ++DL   L++     +   VK  + Q+LRGL Y 
Sbjct: 96  PNIVELKEVVVGNHLE-SIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYL 154

Query: 284 HRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGST 343
           HR  ++HRDLK  NLL+ ++G +K ADFGLARA  +P K  + +VVTLWYR P++LLG+T
Sbjct: 155 HRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTT 214

Query: 344 DYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSNEEFKT 403
             +T IDMW VGCI  E+   RPL PG++   Q+  I ++LGTP+E  WPG         
Sbjct: 215 TQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQ 274

Query: 404 YNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFF 452
           Y+  K     L    P L   G  LL  L  ++ + R +A D ++  +F
Sbjct: 275 YSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYF 323


>gi|4502747 cyclin-dependent kinase 9 [Homo sapiens]
          Length = 372

 Score =  218 bits (555), Expect = 1e-56
 Identities = 123/303 (40%), Positives = 176/303 (58%), Gaps = 15/303 (4%)

Query: 167 KLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLK 225
           ++  Y KL K+G+GT+  V+K + + T   VALK++ +E+E EG P TA+RE+ +L+ LK
Sbjct: 15  EVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLK 74

Query: 226 HANIVTLHDIIHTEKS--------LTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 277
           H N+V L +I  T+ S        + LVF++ + DL   L +      +  +K  +  LL
Sbjct: 75  HENVVNLIEICRTKASPYNRCKGSIYLVFDFCEHDLAGLLSNVLVKFTLSEIKRVMQMLL 134

Query: 278 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKT----YSNEVVTLWY 333
            GL Y HR K+LHRD+K  N+LI   G LKLADFGLARA S+   +    Y+N VVTLWY
Sbjct: 135 NGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWY 194

Query: 334 RPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWP 393
           RPP++LLG  DY   ID+WG GCI  EM T  P+  G+T + QL  I ++ G+ T E WP
Sbjct: 195 RPPELLLGERDYGPPIDLWGAGCIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWP 254

Query: 394 GILSNEEFKTYNYPKYRAEALLSH--APRLDSDGADLLTKLLQFEGRNRISAEDAMKHPF 451
            + + E ++     K +   +     A   D    DL+ KLL  +   RI ++DA+ H F
Sbjct: 255 NVDNYELYEKLELVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDF 314

Query: 452 FLS 454
           F S
Sbjct: 315 FWS 317


>gi|145309302 cell division cycle 2-like 5 isoform 1 [Homo sapiens]
          Length = 1512

 Score =  217 bits (553), Expect = 2e-56
 Identities = 133/393 (33%), Positives = 202/393 (51%), Gaps = 23/393 (5%)

Query: 111  PPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGK--L 168
            PP     +D++K          PE       L+S    K    R       +I +GK  +
Sbjct: 652  PPELPGGDDLSKS---------PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCV 702

Query: 169  ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 227
            + +  +  +GEGTY  VYK + K T  +VALK++RL++E EG P TAIRE+ +L+ L H 
Sbjct: 703  DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762

Query: 228  NIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 277
            +I+ + +I+  ++          +  LVFEY+D DL   L+      N +++K F+ QL+
Sbjct: 763  SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822

Query: 278  RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKTYSNEVVTLWYRPP 336
             GL YCH++  LHRD+K  N+L+N RG++KLADFGLAR   S  ++ Y+N+V+TLWYRPP
Sbjct: 823  EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882

Query: 337  DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 396
            ++LLG   Y+  ID+W  GCI  E+ T +P+F  +    QL  I RI G+P    WP ++
Sbjct: 883  ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 942

Query: 397  SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 456
                F T    K     L      + +   DL   +L  +   R +AE A++  F   + 
Sbjct: 943  KLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002

Query: 457  ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPD 489
                  PD        E+  +K    +   M D
Sbjct: 1003 PSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTD 1035


>gi|145309300 cell division cycle 2-like 5 isoform 2 [Homo sapiens]
          Length = 1452

 Score =  217 bits (553), Expect = 2e-56
 Identities = 133/393 (33%), Positives = 202/393 (51%), Gaps = 23/393 (5%)

Query: 111  PPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGK--L 168
            PP     +D++K          PE       L+S    K    R       +I +GK  +
Sbjct: 652  PPELPGGDDLSKS---------PEEKKTATQLHSKRRPKICGPRYGETKEKDIDWGKRCV 702

Query: 169  ETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTAIREVSLLKDLKHA 227
            + +  +  +GEGTY  VYK + K T  +VALK++RL++E EG P TAIRE+ +L+ L H 
Sbjct: 703  DKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQ 762

Query: 228  NIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNIINMHNVKLFLFQLL 277
            +I+ + +I+  ++          +  LVFEY+D DL   L+      N +++K F+ QL+
Sbjct: 763  SIINMKEIVTDKEDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLM 822

Query: 278  RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKTYSNEVVTLWYRPP 336
             GL YCH++  LHRD+K  N+L+N RG++KLADFGLAR   S  ++ Y+N+V+TLWYRPP
Sbjct: 823  EGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSSEESRPYTNKVITLWYRPP 882

Query: 337  DILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPGIL 396
            ++LLG   Y+  ID+W  GCI  E+ T +P+F  +    QL  I RI G+P    WP ++
Sbjct: 883  ELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRICGSPCPAVWPDVI 942

Query: 397  SNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLG 456
                F T    K     L      + +   DL   +L  +   R +AE A++  F   + 
Sbjct: 943  KLPYFNTMKPKKQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 1002

Query: 457  ERIHKLPDTTSIFALKEIQLQKEASLRSSSMPD 489
                  PD        E+  +K    +   M D
Sbjct: 1003 PSKMPPPDLPLWQDCHELWSKKRRRQKQMGMTD 1035


>gi|157817073 Cdc2-related kinase, arginine/serine-rich isoform 2
            [Homo sapiens]
          Length = 1481

 Score =  215 bits (548), Expect = 7e-56
 Identities = 118/308 (38%), Positives = 177/308 (57%), Gaps = 12/308 (3%)

Query: 156  RRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTA 214
            RR + S+ G   ++ +  +  +GEGTY  VYK K K T  LVALK++RL++E EG P TA
Sbjct: 712  RRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITA 771

Query: 215  IREVSLLKDLKHANIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNII 264
            IRE+ +L+ L H ++V + +I+  ++          +  LVFEY+D DL   L+      
Sbjct: 772  IREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHF 831

Query: 265  NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKT 323
            +  ++K F+ QL+ GL YCH++  LHRD+K  N+L+N  G++KLADFGLAR   S  ++ 
Sbjct: 832  SEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRP 891

Query: 324  YSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRI 383
            Y+N+V+TLWYRPP++LLG   Y+  ID+W  GCI  E+ T +P+F  +    QL  I R+
Sbjct: 892  YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRL 951

Query: 384  LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISA 443
             G+P    WP ++    F T    K     L      + S   DLL  +L  +   R +A
Sbjct: 952  CGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTA 1011

Query: 444  EDAMKHPF 451
            E  ++  F
Sbjct: 1012 EQTLQSDF 1019


>gi|157817023 Cdc2-related kinase, arginine/serine-rich isoform 1
            [Homo sapiens]
          Length = 1490

 Score =  215 bits (548), Expect = 7e-56
 Identities = 118/308 (38%), Positives = 177/308 (57%), Gaps = 12/308 (3%)

Query: 156  RRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHE-EGAPCTA 214
            RR + S+ G   ++ +  +  +GEGTY  VYK K K T  LVALK++RL++E EG P TA
Sbjct: 712  RRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITA 771

Query: 215  IREVSLLKDLKHANIVTLHDIIHTEK----------SLTLVFEYLDKDLKQYLDDCGNII 264
            IRE+ +L+ L H ++V + +I+  ++          +  LVFEY+D DL   L+      
Sbjct: 772  IREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHF 831

Query: 265  NMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARA-KSIPTKT 323
            +  ++K F+ QL+ GL YCH++  LHRD+K  N+L+N  G++KLADFGLAR   S  ++ 
Sbjct: 832  SEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRP 891

Query: 324  YSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRI 383
            Y+N+V+TLWYRPP++LLG   Y+  ID+W  GCI  E+ T +P+F  +    QL  I R+
Sbjct: 892  YTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRL 951

Query: 384  LGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISA 443
             G+P    WP ++    F T    K     L      + S   DLL  +L  +   R +A
Sbjct: 952  CGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTA 1011

Query: 444  EDAMKHPF 451
            E  ++  F
Sbjct: 1012 EQTLQSDF 1019


>gi|223718134 cyclin-dependent kinase 6 [Homo sapiens]
          Length = 326

 Score =  209 bits (533), Expect = 4e-54
 Identities = 127/300 (42%), Positives = 177/300 (59%), Gaps = 20/300 (6%)

Query: 169 ETYIKLDKLGEGTYATVYKGKS-KLTDNLVALKEIRLEH-EEGAPCTAIREVSLLKDLK- 225
           + Y  + ++GEG Y  V+K +  K     VALK +R++  EEG P + IREV++L+ L+ 
Sbjct: 11  QQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLET 70

Query: 226 --HANIVTLHDIIHT-----EKSLTLVFEYLDKDLKQYLDDCGNI-INMHNVKLFLFQLL 277
             H N+V L D+        E  LTLVFE++D+DL  YLD      +    +K  +FQLL
Sbjct: 71  FEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLL 130

Query: 278 RGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPD 337
           RGL + H  +V+HRDLKPQN+L+   G++KLADFGLAR  S      ++ VVTLWYR P+
Sbjct: 131 RGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSF-QMALTSVVVTLWYRAPE 189

Query: 338 ILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEETWPG--I 395
           +LL S+ Y+T +D+W VGCIF EM   +PLF GS+  +QL  I  ++G P EE WP    
Sbjct: 190 VLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVA 248

Query: 396 LSNEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSL 455
           L  + F + +     A+ +      +D  G DLL K L F    RISA  A+ HP+F  L
Sbjct: 249 LPRQAFHSKS-----AQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDL 303


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.136    0.392 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,497,045
Number of Sequences: 37866
Number of extensions: 960029
Number of successful extensions: 6140
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 719
Number of HSP's successfully gapped in prelim test: 126
Number of HSP's that attempted gapping in prelim test: 3731
Number of HSP's gapped (non-prelim): 1163
length of query: 502
length of database: 18,247,518
effective HSP length: 107
effective length of query: 395
effective length of database: 14,195,856
effective search space: 5607363120
effective search space used: 5607363120
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.