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Search of human proteins with 197313636
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
(1464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1 ... 2978 0.0
gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1 pr... 2978 0.0
gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2 ... 2563 0.0
gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor ... 1463 0.0
gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor [... 1019 0.0
gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor ... 976 0.0
gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartat... 299 2e-80
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens] 298 3e-80
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens] 298 3e-80
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens] 298 3e-80
gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate... 250 8e-66
gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1 ... 188 4e-47
gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2 ... 188 4e-47
gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2 ... 186 2e-46
gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1 p... 184 5e-46
gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor ... 183 1e-45
gi|29029597 glutamate receptor KA2 precursor [Homo sapiens] 179 2e-44
gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [H... 177 5e-44
gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1 p... 177 9e-44
gi|29029595 glutamate receptor KA1 precursor [Homo sapiens] 176 1e-43
gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2 p... 176 1e-43
gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [H... 176 1e-43
gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens] 173 1e-42
gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1 p... 172 2e-42
gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [H... 172 3e-42
gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1 pre... 172 3e-42
gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2 p... 172 3e-42
gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2 pr... 171 6e-42
gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [H... 162 2e-39
gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Hom... 38 0.063
>gi|197313636 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 2978 bits (7720), Expect = 0.0
Identities = 1464/1464 (100%), Positives = 1464/1464 (100%)
Query: 1 MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA 60
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
Sbjct: 1 MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA 60
Query: 61 AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT 120
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
Sbjct: 61 AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT 120
Query: 121 FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY 180
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
Sbjct: 121 FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY 180
Query: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL 240
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL 240
Query: 241 SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT 300
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
Sbjct: 241 SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT 300
Query: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
Sbjct: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
Query: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
Sbjct: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
Query: 421 DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV 480
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
Sbjct: 421 DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV 480
Query: 481 TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS 540
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
Sbjct: 481 TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS 540
Query: 541 NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT 600
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
Sbjct: 541 NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT 600
Query: 601 IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD 660
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
Sbjct: 601 IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD 660
Query: 661 QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL 720
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
Sbjct: 661 QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL 720
Query: 721 KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL 780
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
Sbjct: 721 KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL 780
Query: 781 QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL 840
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
Sbjct: 781 QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL 840
Query: 841 FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS 900
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
Sbjct: 841 FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS 900
Query: 901 AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM 960
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
Sbjct: 901 AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM 960
Query: 961 NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS 1020
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
Sbjct: 961 NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS 1020
Query: 1021 IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH 1080
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
Sbjct: 1021 IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH 1080
Query: 1081 KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT 1140
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
Sbjct: 1081 KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT 1140
Query: 1141 LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH 1200
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
Sbjct: 1141 LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH 1200
Query: 1201 SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP 1260
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
Sbjct: 1201 SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP 1260
Query: 1261 ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL 1320
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
Sbjct: 1261 ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL 1320
Query: 1321 EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG 1380
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
Sbjct: 1321 EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG 1380
Query: 1381 RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS 1440
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
Sbjct: 1381 RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS 1440
Query: 1441 TPRVLNSCSNRRVYKKMPSIESDV 1464
TPRVLNSCSNRRVYKKMPSIESDV
Sbjct: 1441 TPRVLNSCSNRRVYKKMPSIESDV 1464
>gi|4504125 N-methyl-D-aspartate receptor subunit 2A isoform 1
precursor [Homo sapiens]
Length = 1464
Score = 2978 bits (7720), Expect = 0.0
Identities = 1464/1464 (100%), Positives = 1464/1464 (100%)
Query: 1 MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA 60
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
Sbjct: 1 MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA 60
Query: 61 AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT 120
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
Sbjct: 61 AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT 120
Query: 121 FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY 180
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
Sbjct: 121 FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY 180
Query: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL 240
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL 240
Query: 241 SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT 300
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
Sbjct: 241 SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT 300
Query: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
Sbjct: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
Query: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
Sbjct: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
Query: 421 DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV 480
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
Sbjct: 421 DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV 480
Query: 481 TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS 540
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
Sbjct: 481 TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS 540
Query: 541 NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT 600
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
Sbjct: 541 NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT 600
Query: 601 IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD 660
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
Sbjct: 601 IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD 660
Query: 661 QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL 720
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
Sbjct: 661 QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL 720
Query: 721 KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL 780
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
Sbjct: 721 KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL 780
Query: 781 QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL 840
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
Sbjct: 781 QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL 840
Query: 841 FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS 900
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
Sbjct: 841 FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS 900
Query: 901 AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM 960
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
Sbjct: 901 AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM 960
Query: 961 NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS 1020
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
Sbjct: 961 NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS 1020
Query: 1021 IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH 1080
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
Sbjct: 1021 IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH 1080
Query: 1081 KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT 1140
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
Sbjct: 1081 KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT 1140
Query: 1141 LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH 1200
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
Sbjct: 1141 LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH 1200
Query: 1201 SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP 1260
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP
Sbjct: 1201 SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNP 1260
Query: 1261 ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL 1320
ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL
Sbjct: 1261 ATGEQVYQQDWAQNNALQLQKNKLRISRQHSYDNIVDKPRELDLSRPSRSISLKDRERLL 1320
Query: 1321 EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG 1380
EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG
Sbjct: 1321 EGNFYGSLFSVPSSKLSGKKSSLFPQGLEDSKRSKSLLPDHTSDNPFLHSHRDDQRLVIG 1380
Query: 1381 RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS 1440
RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS
Sbjct: 1381 RCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHNDVYISEHVMPYAANKNNMYS 1440
Query: 1441 TPRVLNSCSNRRVYKKMPSIESDV 1464
TPRVLNSCSNRRVYKKMPSIESDV
Sbjct: 1441 TPRVLNSCSNRRVYKKMPSIESDV 1464
>gi|197313638 N-methyl-D-aspartate receptor subunit 2A isoform 2
precursor [Homo sapiens]
Length = 1281
Score = 2563 bits (6642), Expect = 0.0
Identities = 1258/1258 (100%), Positives = 1258/1258 (100%)
Query: 1 MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA 60
MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA
Sbjct: 1 MGRVGYWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQA 60
Query: 61 AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT 120
AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT
Sbjct: 61 AGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHT 120
Query: 121 FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY 180
FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY
Sbjct: 121 FVPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGY 180
Query: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL 240
REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL
Sbjct: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLIL 240
Query: 241 SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT 300
SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT
Sbjct: 241 SEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILT 300
Query: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR
Sbjct: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
Query: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE
Sbjct: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
Query: 421 DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV 480
DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV
Sbjct: 421 DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLV 480
Query: 481 TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS 540
TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS
Sbjct: 481 TNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRS 540
Query: 541 NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT 600
NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT
Sbjct: 541 NGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFT 600
Query: 601 IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD 660
IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD
Sbjct: 601 IGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVD 660
Query: 661 QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL 720
QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL
Sbjct: 661 QVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSL 720
Query: 721 KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL 780
KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL
Sbjct: 721 KTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALL 780
Query: 781 QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL 840
QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL
Sbjct: 781 QFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHL 840
Query: 841 FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS 900
FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS
Sbjct: 841 FYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRS 900
Query: 901 AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM 960
AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM
Sbjct: 901 AKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNM 960
Query: 961 NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS 1020
NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS
Sbjct: 961 NELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTESKANSRPRQLWKKSVDS 1020
Query: 1021 IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH 1080
IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH
Sbjct: 1021 IRQDSLSQNPVSQRDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKNH 1080
Query: 1081 KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT 1140
KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT
Sbjct: 1081 KTKDNFKRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGEKEPGFHLDPPQFVENVT 1140
Query: 1141 LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH 1200
LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH
Sbjct: 1141 LPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSNNDQYKLYSKHFTLKDKGSPH 1200
Query: 1201 SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETG 1258
SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETG
Sbjct: 1201 SETSERYRQNSTHCRSCLSNMPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETG 1258
>gi|167003331 N-methyl-D-aspartate receptor subunit 2B precursor [Homo
sapiens]
Length = 1484
Score = 1463 bits (3787), Expect = 0.0
Identities = 803/1513 (53%), Positives = 1031/1513 (68%), Gaps = 94/1513 (6%)
Query: 6 YWTLLVLPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPL 65
+W +L + A+ R A ++K PP++ IAV+L + D E ++ + L +
Sbjct: 12 FWLVLAVLAVSGSR-----ARSQKSPPSIGIAVILVGTSD--EVAIKDAHEKDDFHHLSV 64
Query: 66 DVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPIL 125
V + MN TDPKS+IT +CDLMS +I G+VF DDTDQEA+AQ+LDFIS+ T PIL
Sbjct: 65 VPRVELVAMNETDPKSIITRICDLMSDRKIQGVVFADDTDQEAIAQILDFISAQTLTPIL 124
Query: 126 GIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFIS 185
GIHGG+SMIMADKD +S FFQFG SI+QQA+VML IM++YDW++FS+VTT FPGY++F++
Sbjct: 125 GIHGGSSMIMADKDESSMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFVN 184
Query: 186 FVKTTVDNSFVGWDMQNVITLDTSFED--AKTQVQLKKIHSSVILLYCSKDEAVLILSEA 243
+++T++NSFVGW+++ V+ LD S +D +K Q QLKK+ S +ILLYC+K+EA I A
Sbjct: 185 KIRSTIENSFVGWELEEVLLLDMSLDDGDSKIQNQLKKLQSPIILLYCTKEEATYIFEVA 244
Query: 244 RSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAA 303
S+GLTGY + WIVPSLV+G+T+ +P EFP+GLISVSYD+WDY L ARVRDGI I+TTAA
Sbjct: 245 NSVGLTGYGYTWIVPSLVAGDTDTVPAEFPTGLISVSYDEWDYGLPARVRDGIAIITTAA 304
Query: 304 SSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVV 363
S ML + S+IPE K+SCY E+ + L+ +++NVT++G++LSF+E+GYQ+HP+LV+
Sbjct: 305 SDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVTFEGRNLSFSEDGYQMHPKLVI 364
Query: 364 IVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDID 423
I+LNK+R+WE+VGKW++ +L +++ VWPR ++ E +D+HLSIVTLEEAPFVIVE +D
Sbjct: 365 ILLNKERKWERVGKWKDKSLQMKYYVWPRMCPETE-EQEDDHLSIVTLEEAPFVIVESVD 423
Query: 424 PLTETCVRNTVPCRKFVKINNSTNEGMN-VKKCCKGFCIDILKKLSRTVKFTYDLYLVTN 482
PL+ TC+RNTVPC+K + N T+E +KKCCKGFCIDILKK+S++VKFTYDLYLVTN
Sbjct: 424 PLSGTCMRNTVPCQKRIVTENKTDEEPGYIKKCCKGFCIDILKKISKSVKFTYDLYLVTN 483
Query: 483 GKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNG 542
GKHGKK+N WNGMIGEVV +RA MAVGSLTINEERSEVVDFSVPF+ETGISVMVSRSNG
Sbjct: 484 GKHGKKINGTWNGMIGEVVMKRAYMAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNG 543
Query: 543 TVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIG 602
TVSPSAFLEPFSA VWVMMFVMLLIVSA+AVFVFEYFSPVGYNR LA G+ P GPSFTIG
Sbjct: 544 TVSPSAFLEPFSADVWVMMFVMLLIVSAVAVFVFEYFSPVGYNRCLADGREPGGPSFTIG 603
Query: 603 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQV 662
KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEE+VDQV
Sbjct: 604 KAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEYVDQV 663
Query: 663 TGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKT 722
+GLSDKKFQRP+D+SPPFRFGTVPNGSTERNIRNNY MH YM KFNQ+GV+DAL+SLKT
Sbjct: 664 SGLSDKKFQRPNDFSPPFRFGTVPNGSTERNIRNNYAEMHAYMGKFNQRGVDDALLSLKT 723
Query: 723 GKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQF 782
GKLDAFIYDAAVLNY AGRDEGCKLVTIGSG +FA+TGYGIA+QK S WKRQ+DLA+LQ
Sbjct: 724 GKLDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFASTGYGIAIQKDSGWKRQVDLAILQL 783
Query: 783 VGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842
GDGEMEELE LWLTGICHNEKNEVMSSQLDIDNMAGVFYML AAMALSLITFI EHLFY
Sbjct: 784 FGDGEMEELEALWLTGICHNEKNEVMSSQLDIDNMAGVFYMLGAAMALSLITFICEHLFY 843
Query: 843 WKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKK---KSPDFNLTGSQSNMLKLLR 899
W+ R CF GVCS +PG++FSISRGIYSCIHGV IEE++ SP + + SN+L+LLR
Sbjct: 844 WQFRHCFMGVCSGKPGMVFSISRGIYSCIHGVAIEERQSVMNSPTATMNNTHSNILRLLR 903
Query: 900 SAKNISSMSNMNSSRMDSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQG---KESIF 956
+AKN++++S +N SP+ A DFI+R S + D+ + + +SD +S+ +E++F
Sbjct: 904 TAKNMANLSGVNG----SPQSALDFIRRESSVYDISEHRRSFTHSDCKSYNNPPCEENLF 959
Query: 957 GDNMNELQTFVANRQKDNLNNYVFQGQHPLTLNESNPNTVEVAVSTES-------KANSR 1009
D ++E++ N Q + N Y H P+++ A S + ++
Sbjct: 960 SDYISEVERTFGNLQLKDSNVYQDHYHH-----HHRPHSIGSASSIDGLYDCDNPPFTTQ 1014
Query: 1010 PRQLWKKSVDSIRQDSLSQNPVSQRDEATAENRTHSLKSPRYL-PEEMAHSDISETSNRA 1068
R + KK +D P S+ + + S KS RY +++ SD+S+ S
Sbjct: 1015 SRSISKKPLD-------IGLPSSKHSQLSDLYGKFSFKSDRYSGHDDLIRSDVSDISTHT 1067
Query: 1069 TCHREPDNSKNHKTKDNF-----KRSVASKYPKDCSEVERTYLKTKSSSPRDKIYTIDGE 1123
+ + + + K + KR ++K ++ E+E Y + SP K Y D E
Sbjct: 1068 VTYGNIEGNAAKRRKQQYKDSLKKRPASAKSRREFDEIELAYRRRPPRSPDHKRYFRDKE 1127
Query: 1124 KEPGFHLDPPQFVENVTLPENVDFPDPYQDPSENFRKGDSTLPMNRNPLHNEEGLSN--N 1181
F+LD + EN E+VD D Y++ S++F++ DS P N + +
Sbjct: 1128 GLRDFYLDQFRTKENSPHWEHVDLTDIYKERSDDFKR-DSV--SGGGPCTNRSHIKHGTG 1184
Query: 1182 DQYKLYSKHFTLKDKGSPHSETSERYRQNSTHCRSCLSNMPTYSGHFT-----MRSPFKC 1236
D++ + S +K + E + R CRSC S + YS T ++ +C
Sbjct: 1185 DKHGVVSGVPAPWEKNLTNVEWED--RSGGNFCRSCPSKLHNYSTTVTGQNSGRQACIRC 1242
Query: 1237 DACLRMGNLYDIDEDQMLQETGNPATGEQV--------YQQDWAQNNALQLQKNKLRISR 1288
+AC + GNLYDI ED LQE PA V Y Q + A + +NKLR R
Sbjct: 1243 EACKKAGNLYDISEDNSLQELDQPAAPVAVTSNASTTKYPQSPTNSKAQKKNRNKLR--R 1300
Query: 1289 QHSYDNIVDKPRELDLSRPSRSISLKDRERLLEGNFYGSLF--SVPSSKLSGKKSSLFPQ 1346
QHSYD VD +E + + RS+SLKD+ R ++G+ Y +F S S + KSS+
Sbjct: 1301 QHSYDTFVDLQKE-EAALAPRSVSLKDKGRFMDGSPYAHMFEMSAGESTFANNKSSVPTA 1359
Query: 1347 GLEDSKR-------SKSLLPDHTSDNPFLHSHRDDQRLVIGRCPSDPYKHSLPSQAVNDS 1399
G SKSL PD + NPF+ + DDQ L+ G S Y P+ A S
Sbjct: 1360 GHHHHNNPGGGYMLSKSLYPDRVTQNPFIPTFGDDQCLLHG---SKSYFFRQPTVA-GAS 1415
Query: 1400 YLRSSLRS--------TASYCSRDSRGHNDVYISEHVMPYAANKNNMYSTPRVLNSCSNR 1451
R R+ +A + + +R D+ I P N N PR N SN
Sbjct: 1416 KARPDFRALVTNKPVVSALHGAVPARFQKDICIGNQSNPCVPNNKN----PRAFNGSSNG 1471
Query: 1452 RVYKKMPSIESDV 1464
VY+K+ SIESDV
Sbjct: 1472 HVYEKLSSIESDV 1484
>gi|55770854 N-methyl-D-aspartate receptor subunit 2C precursor
[Homo sapiens]
Length = 1233
Score = 1019 bits (2635), Expect = 0.0
Identities = 512/915 (55%), Positives = 654/915 (71%), Gaps = 23/915 (2%)
Query: 13 PALLV------WRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLD 66
PALL+ W G P +G + +AV+ S + + R P+ LPL+
Sbjct: 7 PALLLTSLFGAWAGLGPG----QGEQGMTVAVVFSSSGP-PQAQFRARLTPQSFLDLPLE 61
Query: 67 VNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILG 126
+ + + +N T+P SL+T +C L+ A +HG+VF D+ D EAVAQ+LDFISS T VPIL
Sbjct: 62 IQPLTVGVNTTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILS 121
Query: 127 IHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISF 186
I GG+++++ K+P S F Q G S++QQ V+ K++++YDW F+++T++ PG+ F+
Sbjct: 122 ISGGSAVVLTPKEPGSAFLQLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEG 181
Query: 187 VKTTVDNSFVGWDMQNVITLDTS--FEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEAR 244
V+ D S V W + +V+TL+ A+TQ L+++ + V + YCS++EA ++ +EA
Sbjct: 182 VRAVADASHVSWRLLDVVTLELGPGGPRARTQRLLRQLDAPVFVAYCSREEAEVLFAEAA 241
Query: 245 SLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGILTTAAS 304
GL G W+VP+L G+T+ P FP GLISV + W SL +VRDG+ IL A
Sbjct: 242 QAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTESWRLSLRQKVRDGVAILALGAH 301
Query: 305 SMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPRLVVI 364
S + +P C + ++NVTW+G+D SF+ GY V P +VVI
Sbjct: 302 SYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPGGYLVQPTMVVI 361
Query: 365 VLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424
LN+ R WE VG+WE+ L +++ VWPRY + D HL++ TLEE PFVIVE DP
Sbjct: 362 ALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPDP 421
Query: 425 LTETCVRNTVPCRKFVKINNSTNEG---MNVKKCCKGFCIDILKKLSRTVKFTYDLYLVT 481
T CV NTVPCR+ + N++ + G K CCKGFCIDILKKL+R VKF+YDLYLVT
Sbjct: 422 GTGGCVPNTVPCRR--QSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479
Query: 482 NGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSN 541
NGKHGK+V VWNGMIGEV Y+RA MA+GSLTINEERSE+VDFSVPFVETGISVMV+RSN
Sbjct: 480 NGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSN 539
Query: 542 GTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTI 601
GTVSPSAFLEP+S +VWVMMFVM L V AI VF+FEYFSPV YN+NL +GK GP+FTI
Sbjct: 540 GTVSPSAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTI 599
Query: 602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 661
GK++WLLW LVFNNSVP++NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQE+++D
Sbjct: 600 GKSVWLLWALVFNNSVPIENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDT 659
Query: 662 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLK 721
V+GLSDKKFQRP D PPFRFGTVPNGSTERNIR+NY MH +M KFNQ+ VEDAL SLK
Sbjct: 660 VSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMHTHMVKFNQRSVEDALTSLK 719
Query: 722 TGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQ 781
GKLDAFIYDAAVLNY AG+DEGCKLVTIGSG +FATTGYGIA+QK S WKR IDLALLQ
Sbjct: 720 MGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQ 779
Query: 782 FVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
F+GDGE ++LET+WL+GIC NEKNEVMSS+LDIDNMAGVFYML AM L+L+ F WEHL
Sbjct: 780 FLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLV 839
Query: 842 YWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVH---IEEKKKSPDFNLTGSQSNMLKLL 898
YWKLR S + L + SRGIYSC GV ++ SPD + +Q+++LK+L
Sbjct: 840 YWKLRHSVPN--SSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKML 897
Query: 899 RSAKNISSMSNMNSS 913
++A+++ + + ++SS
Sbjct: 898 QAARDMVTTAGVSSS 912
>gi|153946391 N-methyl-D-aspartate receptor subunit 2D precursor
[Homo sapiens]
Length = 1336
Score = 976 bits (2522), Expect = 0.0
Identities = 489/872 (56%), Positives = 617/872 (70%), Gaps = 39/872 (4%)
Query: 12 LPALLVWRGPAPSAAAEKGPPALNIAVMLGHSHDVTERELRTLWGPEQAAGLPLDVNVVA 71
L LV+ GPA +A A + PA+ AV ++ G LDV VA
Sbjct: 51 LNVALVFSGPAYAAEAARLGPAVAAAV--------------------RSPG--LDVRPVA 88
Query: 72 LLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGA 131
L++N +DP+SL+ +CDL+SG R+HG+VF DD+ AVA +LDF+S+ T +PI+ +HGGA
Sbjct: 89 LVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGA 148
Query: 132 SMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTV 191
++++ K+ STF Q G+S +QQ V+ +++++YDW F VTT PG+R F+S+++
Sbjct: 149 ALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLT 208
Query: 192 DNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGY 251
D S VGW+ + +TLD +A QL+ + + + LL+C+++EA + A GLTG
Sbjct: 209 DGSLVGWEHRGALTLDPGAGEAVLSAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGS 268
Query: 252 DFFWIV--PSLVSGNTELIPKE---------FPSGLISVSYDDWDYSLEARVRDGIGILT 300
+ W + P L G P E P+GL +V W L RV G+ ++
Sbjct: 269 GYVWFMVGPQLAGGGGSGAPGEPPLLPGGAPLPAGLFAVRSAGWRDDLARRVAAGVAVVA 328
Query: 301 TAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQVHPR 360
A ++L + ++PE C Q +LH + +N+TWD +D SF E+G+ V+P
Sbjct: 329 RGAQALLRDYGFLPELGHDCRAQNRTHR--GESLHRYFMNITWDNRDYSFNEDGFLVNPS 386
Query: 361 LVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVE 420
LVVI L +DR WE VG WE TL L++ +W RY F D HL++ TLEE PFVIVE
Sbjct: 387 LVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVE 446
Query: 421 DIDPLTETCVRNTVPCRKFVKINNS--TNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLY 478
DP++ TC+R++VPCR + +S + K+CCKGFCIDILK+L+ T+ F+YDLY
Sbjct: 447 PADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLY 506
Query: 479 LVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVS 538
LVTNGKHGKK++ VWNGMIGEV YQRA MA+GSLTINEERSE+VDFSVPFVETGISVMV+
Sbjct: 507 LVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVA 566
Query: 539 RSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPS 598
RSNGTVSPSAFLEP+S +VWVMMFVM L V A+ VF+FEY SPVGYNR+LA GK P G +
Sbjct: 567 RSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGST 626
Query: 599 FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEF 658
FTIGK+IWLLW LVFNNSVPV+NP+GTTSKIMV VWAFFAVIFLASYTANLAAFMIQEE+
Sbjct: 627 FTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEY 686
Query: 659 VDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALV 718
VD V+GLSD+KFQRP + PP +FGTVPNGSTE+NIR+NYP MH YM ++NQ VE+AL
Sbjct: 687 VDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALT 746
Query: 719 SLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLA 778
LK GKLDAFIYDAAVLNY A +DEGCKLVTIGSG +FATTGYGIAL KGS WKR IDLA
Sbjct: 747 QLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLA 806
Query: 779 LLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWE 838
LLQF+GD E+E LE LWL+GICHN+K EVMSS+LDIDNMAGVFYML AM LSL+ F WE
Sbjct: 807 LLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWE 866
Query: 839 HLFYWKLRFCFTGVCSDRPGLLFSISRGIYSC 870
HL YW+LR C + R L + SRG+YSC
Sbjct: 867 HLVYWRLRHCLGP--THRMDFLLAFSRGMYSC 896
>gi|223278356 glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
[Homo sapiens]
Length = 1115
Score = 299 bits (765), Expect = 2e-80
Identities = 238/875 (27%), Positives = 421/875 (48%), Gaps = 66/875 (7%)
Query: 77 TDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPILGIHGGASMIMA 136
+DP S + VC + + L+ + E + LD +S +P++ I
Sbjct: 175 SDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMME--LDLVSLVLHIPVISIVRH-EFPRE 231
Query: 137 DKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFV 196
++P S+ A V + I+ +W+ FSL+ + F+ T +NS
Sbjct: 232 SQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLL--LCQEDWNITDFLLLTQNNS-- 287
Query: 197 GWDMQNVITLDTSFEDAKT-----QVQLKKIHSS---VILLYCSKDEAVLILSEARSLGL 248
+ + ++I + + + Q+QL+ I +S V++ C + I G+
Sbjct: 288 KFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGV 347
Query: 249 TGYDFFWIVPSLVSGNTELIPKE-FPSGLISVSYDDWDYSLEARVRDGIGILT--TAASS 305
+ W++ S N E + E P GLI+ E V+D + ++ A ++
Sbjct: 348 MPPELRWVLGD--SQNVEELRTEGLPLGLIAHGKTTQSV-FEHYVQDAMELVARAVATAT 404
Query: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKDLSFTEEGYQV---HPRLV 362
M++ + + +C L F+ N T+ G S +G +
Sbjct: 405 MIQPELALIPSTMNCMEVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFF 464
Query: 363 VIVLNKDRE----WEKVGKWENHTLSLRHAVWP----RYKSFSDCEPDDNHLSIVTLEEA 414
+ L D W ++G W+ + + + +WP R+K+ P HL +VTL E
Sbjct: 465 IWNLQHDPMGKPMWTRLGSWQGGKIVMDYGIWPEQAQRHKTHFQ-HPSKLHLRVVTLIEH 523
Query: 415 PFVIVEDID-----PLTETCV----RNTVPCRKFVKINNSTNEGMNVK--KCCKGFCIDI 463
PFV ++D P + C+ ++ +S+N+ + +K KCC G+CID+
Sbjct: 524 PFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSSLHSSNDTVPIKFKKCCYGYCIDL 583
Query: 464 LKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVD 523
L+K++ + F +DLY+V +GK+G N W G++G+++ A MAV S +IN RS+V+D
Sbjct: 584 LEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVTSFSINTARSQVID 643
Query: 524 FSVPFVETGISVMVSRSNGTVSP-SAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPV 582
F+ PF T + ++V R+ T +P AF+ P ++W+ +FV L I +A+ + ++E+ SP
Sbjct: 644 FTSPFFSTSLGILV-RTRDTAAPIGAFMWPLHWTMWLGIFVALHI-TAVFLTLYEWKSPF 701
Query: 583 GYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFL 642
G KG+ F+ A+ + + L+F +V ++ PK T + ++++WA F + L
Sbjct: 702 GLT---PKGR-NRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCL 757
Query: 643 ASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMH 702
++YTANLAA M+ E+ ++++G+ D K P S FRFGTV S E +R ++P MH
Sbjct: 758 STYTANLAAVMVGEKIYEELSGIHDPKLHHP---SQGFRFGTVRESSAEDYVRQSFPEMH 814
Query: 703 QYMTKFNQKGVEDALVSLKTG--KLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTG 760
+YM ++N D + LK KLDAFI D A+L+Y+ D CKL+T+G FA G
Sbjct: 815 EYMRRYNVPATPDGVEYLKNDPEKLDAFIMDKALLDYEVSIDADCKLLTVGKP--FAIEG 872
Query: 761 YGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSS--QLDIDNMA 818
YGI L SP I + Q+ G M+ L W + +++ ++ Q+ I + +
Sbjct: 873 YGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRVVPCGKRSFAVTETLQMGIKHFS 932
Query: 819 GVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSI--SRGIYSCIHGVHI 876
G+F +L LS++T I EH+ Y R + ++ L + + S+ ++ I+ I
Sbjct: 933 GLFVLLCIGFGLSILTTIGEHIVY---RLLLPRI-KNKSKLQYWLHTSQRLHRAINTSFI 988
Query: 877 EEKKKSPDFNLTGSQSNMLKLLRSAKNISSMSNMN 911
EEK++ +SN+ + N S++S+ N
Sbjct: 989 EEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDN 1023
>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
Length = 885
Score = 298 bits (762), Expect = 3e-80
Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)
Query: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180
+P+LG+ S I +DK +F + Q++V ++M+ Y W H+ LV+ G
Sbjct: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
Query: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239
R ++T ++ + V+ D ++ + + K++ + VI+L S+D+A +
Sbjct: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
Query: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298
A L +TG + W+V +SGN + P G++ + + A + D +G+
Sbjct: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
Query: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356
+ A +LEK + I + C G + M + DG + F E+G +
Sbjct: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
Query: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413
++ L ++R+ +VG + H + + R +WP ++ L IVT+ +
Sbjct: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
Query: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466
PFV V+ E N P +K + N T+ G V +CC GFCID+L K
Sbjct: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
Query: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520
L+RT+ FTY+++LV +GK G ++VNN WNGM+GE++ +A M V LTIN ER++
Sbjct: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
Query: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580
++FS PF G++++V + + +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
Query: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640
P G R + + T+ A+W WG++ N+ + P+ +++I+ VWA FA+I
Sbjct: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
Query: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700
+ASYTANLAAF++ + +++TG++D + + P D F + TV S + R
Sbjct: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
Query: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758
M+++M K N + +A+ +++ KL AFI+D+AVL ++A + C LVT +G +F
Sbjct: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
Query: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817
+G+GI ++K SPWK+ + L++L+ +G ME+L+ W+ C + N + L +NM
Sbjct: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
Query: 818 AGVFYMLAAAMALSLITFIWE 838
AGVF ++A + + E
Sbjct: 814 AGVFMLVAGGIVAGIFLIFIE 834
>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
Length = 938
Score = 298 bits (762), Expect = 3e-80
Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)
Query: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180
+P+LG+ S I +DK +F + Q++V ++M+ Y W H+ LV+ G
Sbjct: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
Query: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239
R ++T ++ + V+ D ++ + + K++ + VI+L S+D+A +
Sbjct: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
Query: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298
A L +TG + W+V +SGN + P G++ + + A + D +G+
Sbjct: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
Query: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356
+ A +LEK + I + C G + M + DG + F E+G +
Sbjct: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
Query: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413
++ L ++R+ +VG + H + + R +WP ++ L IVT+ +
Sbjct: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
Query: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466
PFV V+ E N P +K + N T+ G V +CC GFCID+L K
Sbjct: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
Query: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520
L+RT+ FTY+++LV +GK G ++VNN WNGM+GE++ +A M V LTIN ER++
Sbjct: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
Query: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580
++FS PF G++++V + + +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
Query: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640
P G R + + T+ A+W WG++ N+ + P+ +++I+ VWA FA+I
Sbjct: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
Query: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700
+ASYTANLAAF++ + +++TG++D + + P D F + TV S + R
Sbjct: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
Query: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758
M+++M K N + +A+ +++ KL AFI+D+AVL ++A + C LVT +G +F
Sbjct: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
Query: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817
+G+GI ++K SPWK+ + L++L+ +G ME+L+ W+ C + N + L +NM
Sbjct: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
Query: 818 AGVFYMLAAAMALSLITFIWE 838
AGVF ++A + + E
Sbjct: 814 AGVFMLVAGGIVAGIFLIFIE 834
>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
Length = 901
Score = 298 bits (762), Expect = 3e-80
Identities = 215/741 (29%), Positives = 388/741 (52%), Gaps = 46/741 (6%)
Query: 122 VPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDW-HVFSLVTTIFPGY 180
+P+LG+ S I +DK +F + Q++V ++M+ Y W H+ LV+ G
Sbjct: 116 IPVLGLTTRMS-IYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG- 173
Query: 181 REFISFVKTTVDNSFVGWDMQNVITLDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLI 239
R ++T ++ + V+ D ++ + + K++ + VI+L S+D+A +
Sbjct: 174 RAAQKRLETLLEERES--KAEKVLQFDPGTKNVTALLMEAKELEARVIILSASEDDAATV 231
Query: 240 LSEARSLGLTGYDFFWIVPSL-VSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGIGI 298
A L +TG + W+V +SGN + P G++ + + A + D +G+
Sbjct: 232 YRAAAMLNMTGSGYVWLVGEREISGNAL---RYAPDGILGLQLINGKNE-SAHISDAVGV 287
Query: 299 LTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGKD--LSFTEEGYQ 356
+ A +LEK + I + C G + M + DG + F E+G +
Sbjct: 288 VAQAVHELLEKEN-ITDPPRGCVGNTNIWKTGPLFKRVLMSSKYADGVTGRVEFNEDGDR 346
Query: 357 VHPRLVVIVLNKDREWEKVGKWEN-HTL-SLRHAVWPRYKSFSDCEPD-DNHLSIVTLEE 413
++ L ++R+ +VG + H + + R +WP ++ L IVT+ +
Sbjct: 347 KFANYSIMNL-QNRKLVQVGIYNGTHVIPNDRKIIWPGGETEKPRGYQMSTRLKIVTIHQ 405
Query: 414 APFVIVEDI---DPLTETCVRNTVPCRKFVKIN-NSTNEGM---NVKKCCKGFCIDILKK 466
PFV V+ E N P +K + N T+ G V +CC GFCID+L K
Sbjct: 406 EPFVYVKPTLSDGTCKEEFTVNGDPVKKVICTGPNDTSPGSPRHTVPQCCYGFCIDLLIK 465
Query: 467 LSRTVKFTYDLYLVTNGKHG--KKVNNV----WNGMIGEVVYQRAVMAVGSLTINEERSE 520
L+RT+ FTY+++LV +GK G ++VNN WNGM+GE++ +A M V LTIN ER++
Sbjct: 466 LARTMNFTYEVHLVADGKFGTQERVNNSNKKEWNGMMGELLSGQADMIVAPLTINNERAQ 525
Query: 521 VVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFS 580
++FS PF G++++V + + +F++PF +++W+++ + + +V A+ +++ + FS
Sbjct: 526 YIEFSKPFKYQGLTILVKKEIPRSTLDSFMQPFQSTLWLLVGLSVHVV-AVMLYLLDRFS 584
Query: 581 PVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVI 640
P G R + + T+ A+W WG++ N+ + P+ +++I+ VWA FA+I
Sbjct: 585 PFG--RFKVNSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMI 642
Query: 641 FLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPY 700
+ASYTANLAAF++ + +++TG++D + + P D F + TV S + R
Sbjct: 643 IVASYTANLAAFLVLDRPEERITGINDPRLRNPSD---KFIYATVKQSSVDIYFRRQVEL 699
Query: 701 --MHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFAT 758
M+++M K N + +A+ +++ KL AFI+D+AVL ++A + C LVT +G +F
Sbjct: 700 STMYRHMEKHNYESAAEAIQAVRDNKLHAFIWDSAVLEFEA--SQKCDLVT--TGELFFR 755
Query: 759 TGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT-GICHNEKNEVMSSQLDIDNM 817
+G+GI ++K SPWK+ + L++L+ +G ME+L+ W+ C + N + L +NM
Sbjct: 756 SGFGIGMRKDSPWKQNVSLSILKSHENGFMEDLDKTWVRYQECDSRSN--APATLTFENM 813
Query: 818 AGVFYMLAAAMALSLITFIWE 838
AGVF ++A + + E
Sbjct: 814 AGVFMLVAGGIVAGIFLIFIE 834
>gi|62988346 glutamate receptor, ionotropic, N-methyl-D-aspartate 3B
[Homo sapiens]
Length = 1043
Score = 250 bits (638), Expect = 8e-66
Identities = 234/840 (27%), Positives = 387/840 (46%), Gaps = 115/840 (13%)
Query: 65 LDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSHTFVPI 124
L + +V DP SL +C + + L+ + E + L F+++ T P+
Sbjct: 70 LSLELVVAAPPARDPASLTRGLCQALVPPGVAALLAFPEARPELL--QLHFLAAATETPV 127
Query: 125 LGI-HGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHV--FSLVTTIFPGYR 181
L + A + +P + + ++ V++ ++Q + W +L T PG
Sbjct: 128 LSLLRREARAPLGAPNPFHLQLHWASPLETLLDVLVAVLQAHAWEDVGLALCRTQDPGGL 187
Query: 182 EFISFVKTTVDNSFVGWDMQNVITL---DTSFEDAKTQVQLKKIHSSV---------ILL 229
+ S G Q V+ L DT DA + +L + + V +LL
Sbjct: 188 -------VALWTSRAGRPPQLVLDLSRRDTG--DAGLRARLAPMAAPVGGEAPVPAAVLL 238
Query: 230 YCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPS-----GLISVSYDDW 284
C A +L EA G W++ T L PK P+ GL+++ +
Sbjct: 239 GCDIARARRVL-EAVPPGP-----HWLL------GTPLPPKALPTAGLPPGLLALG-EVA 285
Query: 285 DYSLEARVRDGIGILTTAASSMLE---KFSYIPEAKASCYG-QMERPEVPMHTLHPFMVN 340
LEA + D + ++ A S + K + +P A +C Q PE P L F+ N
Sbjct: 286 RPPLEAAIHDIVQLVARALGSAAQVQPKRALLP-APVNCGDLQPAGPESPGRFLARFLAN 344
Query: 341 VTWDGKDLSFTEEGY-QVHPRLVVIVLNKDRE------WEKVGKWENHTLSLRHA----- 388
++ G+ G QVH V + R+ W VG W + L L
Sbjct: 345 TSFQGRTGPVWVTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASAR 404
Query: 389 --------VWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDID-----PLTETCV----- 430
VWP+ L +VTL E PFV D D P + C+
Sbjct: 405 PPPPQGAQVWPK-------------LRVVTLLEHPFVFARDPDEDGQCPAGQLCLDPGTN 451
Query: 431 -RNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV 489
T+ N S + +KCC G+CID+L++L+ F ++LYLV +GK+G
Sbjct: 452 DSATLDALFAALANGSAPRAL--RKCCYGYCIDLLERLAEDTPFDFELYLVGDGKYGALR 509
Query: 490 NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSP-SA 548
+ W G++G+++ RA MAV S +IN RS+VVDF+ PF T + +MV R+ T SP A
Sbjct: 510 DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMV-RARDTASPIGA 568
Query: 549 FLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLL 608
F+ P S W+ +F L + +A+ + V+E+ SP G L F+ A+ L
Sbjct: 569 FMWPLHWSTWLGVFAALHL-TALFLTVYEWRSPYG----LTPRGRNRSTVFSYSSALNLC 623
Query: 609 WGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDK 668
+ ++F +V + PK T ++++++WA F ++ L+SYTANLAA M+ ++ ++++G+ D
Sbjct: 624 YAILFRRTVSSKTPKCPTGRLLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDP 683
Query: 669 KFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFN----QKGVEDALVSLKTGK 724
K P + FRFGTV S E I+ ++P MH +M + + +GV A+++ K
Sbjct: 684 KLHHP---AQGFRFGTVWESSAEAYIKKSFPDMHAHMRRHSAPTTPRGV--AMLTSDPPK 738
Query: 725 LDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVG 784
L+AFI D ++L+Y+ D CKL+T+G FA GYGI L + SP + + ++
Sbjct: 739 LNAFIMDKSLLDYEVSIDADCKLLTVGKP--FAIEGYGIGLPQNSPLTSNLSEFISRYKS 796
Query: 785 DGEMEELETLWLTGI-CHNEKNEVMSS-QLDIDNMAGVFYMLAAAMALSLITFIWEHLFY 842
G ++ L W + C V + Q+ I + AG+F +L + +L++ + EH F+
Sbjct: 797 SGFIDLLHDKWYKMVPCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALLSSLGEHAFF 856
>gi|11386137 glutamate receptor, ionotropic, kainate 2 isoform 1
precursor [Homo sapiens]
Length = 908
Score = 188 bits (477), Expect = 4e-47
Identities = 182/694 (26%), Positives = 318/694 (45%), Gaps = 111/694 (15%)
Query: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGN 264
L +DAK + ++K+ ++ CS + A IL +A ++G+ + +I +L
Sbjct: 204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263
Query: 265 TELIPKEFPSGL--------------ISVSYDDWDYS-LEARVRDGIGIL----TTAASS 305
++ P + SG+ +S + W L+A + G+L TT A+
Sbjct: 264 LDVEPYRY-SGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAAL 322
Query: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVT---------WDGKDLSFT---EE 353
M + + A + QM + + P+ W+G T
Sbjct: 323 MYDAVHVVSVAVQQ-FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTN 381
Query: 354 GYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412
G + L VI L K+ EK+G W+ + L++ + + + +D + L + T+
Sbjct: 382 GLRTDFDLDVISL-KEEGLEKIGTWDPASGLNMTESQKGKPANITD-SLSNRSLIVTTIL 439
Query: 413 EAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471
E P+V+ + D PL N EG +CID+L++LS +
Sbjct: 440 EEPYVLFKKSDKPL----------------YGNDRFEG---------YCIDLLRELSTIL 474
Query: 472 KFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFV 529
FTY++ LV +GK+G + N WNGM+ E++ +A +AV L I R +V+DFS PF+
Sbjct: 475 GFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFM 534
Query: 530 ETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNR 586
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV FSP YN
Sbjct: 535 TLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNP 592
Query: 587 NLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639
+ P P +FT+ + W G + + PK +++I+ +W FF +
Sbjct: 593 H------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTL 645
Query: 640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIR 695
I ++SYTANLAAF+ E + D Q +Y G V +G+T +++
Sbjct: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVEDGATMTFFKKSKI 699
Query: 696 NNYPYMHQYMT--------KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747
+ Y M +M+ K N++G++ L S AF+ ++ + + R+ C L
Sbjct: 700 STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNL 752
Query: 748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEV 807
IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G E+
Sbjct: 753 TQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESK 810
Query: 808 MSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
+S L + N+ G+F +LAA + LS+ + E L+
Sbjct: 811 EASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
>gi|28559003 glutamate receptor, ionotropic, kainate 2 isoform 2
precursor [Homo sapiens]
Length = 869
Score = 188 bits (477), Expect = 4e-47
Identities = 182/694 (26%), Positives = 318/694 (45%), Gaps = 111/694 (15%)
Query: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGN 264
L +DAK + ++K+ ++ CS + A IL +A ++G+ + +I +L
Sbjct: 204 LPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFA 263
Query: 265 TELIPKEFPSGL--------------ISVSYDDWDYS-LEARVRDGIGIL----TTAASS 305
++ P + SG+ +S + W L+A + G+L TT A+
Sbjct: 264 LDVEPYRY-SGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAAL 322
Query: 306 MLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVT---------WDGKDLSFT---EE 353
M + + A + QM + + P+ W+G T
Sbjct: 323 MYDAVHVVSVAVQQ-FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTN 381
Query: 354 GYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLE 412
G + L VI L K+ EK+G W+ + L++ + + + +D + L + T+
Sbjct: 382 GLRTDFDLDVISL-KEEGLEKIGTWDPASGLNMTESQKGKPANITD-SLSNRSLIVTTIL 439
Query: 413 EAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTV 471
E P+V+ + D PL N EG +CID+L++LS +
Sbjct: 440 EEPYVLFKKSDKPL----------------YGNDRFEG---------YCIDLLRELSTIL 474
Query: 472 KFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFV 529
FTY++ LV +GK+G + N WNGM+ E++ +A +AV L I R +V+DFS PF+
Sbjct: 475 GFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFM 534
Query: 530 ETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNR 586
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV FSP YN
Sbjct: 535 TLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYILLAYLGVSCV-LFVIARFSPYEWYNP 592
Query: 587 NLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAV 639
+ P P +FT+ + W G + + PK +++I+ +W FF +
Sbjct: 593 H------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTL 645
Query: 640 IFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIR 695
I ++SYTANLAAF+ E + D Q +Y G V +G+T +++
Sbjct: 646 IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVEDGATMTFFKKSKI 699
Query: 696 NNYPYMHQYMT--------KFNQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKL 747
+ Y M +M+ K N++G++ L S AF+ ++ + + R+ C L
Sbjct: 700 STYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDY-----AFLMESTTIEFVTQRN--CNL 752
Query: 748 VTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEV 807
IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G E+
Sbjct: 753 TQIGG--LIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESK 810
Query: 808 MSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
+S L + N+ G+F +LAA + LS+ + E L+
Sbjct: 811 EASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLY 844
>gi|28416444 glutamate receptor, ionotropic, kainate 1 isoform 2
precursor [Homo sapiens]
Length = 905
Score = 186 bits (471), Expect = 2e-46
Identities = 181/687 (26%), Positives = 310/687 (45%), Gaps = 98/687 (14%)
Query: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTG--YDFFWIVPSLVS 262
L + +DAK + ++KK ++ CS + A IL + +G+ Y +F+ L +
Sbjct: 205 LPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFA 264
Query: 263 GNTELIPKE-----------FPSGLISVSYDDWDYS-LEARVRDGIGIL----TTAASSM 306
+ EL + +S + W L+A R G+L TT A+ M
Sbjct: 265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALM 324
Query: 307 LEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN---------VTWDGKDLSFT---EEG 354
+ Y+ + Q+ + H P+ + WDG T G
Sbjct: 325 YDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNG 383
Query: 355 YQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEE 413
+ L +I L K+ EK+G W +++ L++ + + + +D + L + T+ E
Sbjct: 384 LRKDFDLDIISL-KEEGTEKIGIWNSNSGLNMTDSNKDKSSNITDSLANRT-LIVTTILE 441
Query: 414 APFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVK 472
P+V+ D PL N EG +C+D+LK+LS +
Sbjct: 442 EPYVMYRKSDKPL----------------YGNDRFEG---------YCLDLLKELSNILG 476
Query: 473 FTYDLYLVTNGKHGKKVNN-VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVET 531
F YD+ LV +GK+G + + WNGM+ E++ RA +AV LTI R +V+DFS PF+
Sbjct: 477 FIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTL 536
Query: 532 GISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVG-YNRNL 588
GIS++ + NGT +P +FL P S +W+ + + L VS + +FV F+P YN +
Sbjct: 537 GISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-LFVIARFTPYEWYNPH- 593
Query: 589 AKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIF 641
P P +FT+ + W G + + PK +++I+ +W FF +I
Sbjct: 594 -----PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKALSTRIVGGIWWFFTLII 647
Query: 642 LASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYM 701
++SYTANLAAF+ E + D Q +Y G V +GST + +
Sbjct: 648 ISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAVRDGSTMTFFKKSKIST 701
Query: 702 HQYMTKFNQKGVEDALVSLKTGKLD-------AFIYDAAVLNYKAGRDEGCKLVTIGSGY 754
++ M F + ALV + A + ++ + Y R+ C L IG
Sbjct: 702 YEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYVTQRN--CNLTQIGG-- 757
Query: 755 IFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDI 814
+ + GYG+ GSP++ +I +A+LQ +G++ ++ W G E++ +S L +
Sbjct: 758 LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDNKEASALGV 817
Query: 815 DNMAGVFYMLAAAMALSLITFIWEHLF 841
+N+ G+F +LAA + LS+ I E ++
Sbjct: 818 ENIGGIFIVLAAGLVLSVFVAIGEFIY 844
>gi|4504117 glutamate receptor, ionotropic, kainate 1 isoform 1
precursor [Homo sapiens]
Length = 918
Score = 184 bits (467), Expect = 5e-46
Identities = 184/703 (26%), Positives = 313/703 (44%), Gaps = 115/703 (16%)
Query: 206 LDTSFEDAKTQV-QLKKIHSSVILLYCSKDEAVLILSEARSLGLTG--YDFFWIVPSLVS 262
L + +DAK + ++KK ++ CS + A IL + +G+ Y +F+ L +
Sbjct: 205 LPSGNKDAKPLLKEMKKGKEFYVIFDCSHETAAEILKQILFMGMMTEYYHYFFTTLDLFA 264
Query: 263 GNTELIPKE-----------FPSGLISVSYDDWDYS-LEARVRDGIGIL----TTAASSM 306
+ EL + +S + W L+A R G+L TT A+ M
Sbjct: 265 LDLELYRYSGVNMTGFRLLNIDNPHVSSIIEKWSMERLQAPPRPETGLLDGMMTTEAALM 324
Query: 307 LEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVN---------VTWDG------------ 345
+ Y+ + Q+ + H P+ + WDG
Sbjct: 325 YDAV-YMVAIASHRASQLTVSSLQCHRHKPWRLGPRFMNLIKEARWDGLTGHITFNKTNG 383
Query: 346 --KD-----LSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHT-LSLRHAVWPRYKSFS 397
KD +S EEG + V L K W+K+G W +++ L++ + + + +
Sbjct: 384 LRKDFDLDIISLKEEGTEKAAGEVSKHLYK--VWKKIGIWNSNSGLNMTDSNKDKSSNIT 441
Query: 398 DCEPDDNHLSIVTLEEAPFVIVEDID-PLTETCVRNTVPCRKFVKINNSTNEGMNVKKCC 456
D + L + T+ E P+V+ D PL N EG
Sbjct: 442 DSLANRT-LIVTTILEEPYVMYRKSDKPL----------------YGNDRFEG------- 477
Query: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNN-VWNGMIGEVVYQRAVMAVGSLTIN 515
+C+D+LK+LS + F YD+ LV +GK+G + + WNGM+ E++ RA +AV LTI
Sbjct: 478 --YCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTIT 535
Query: 516 EERSEVVDFSVPFVETGISVMVSRSNGTVSPS--AFLEPFSASVWVMMFVMLLIVSAIAV 573
R +V+DFS PF+ GIS++ + NGT +P +FL P S +W+ + + L VS + +
Sbjct: 536 YVREKVIDFSKPFMTLGISILYRKPNGT-NPGVFSFLNPLSPDIWMYVLLACLGVSCV-L 593
Query: 574 FVFEYFSPVG-YNRNLAKGKAPHGP-------SFTIGKAIWLLWGLVFNNSVPVQNPKGT 625
FV F+P YN + P P +FT+ + W G + + PK
Sbjct: 594 FVIARFTPYEWYNPH------PCNPDSDVVENNFTLLNSFWFGVGALMQQGSELM-PKAL 646
Query: 626 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTV 685
+++I+ +W FF +I ++SYTANLAAF+ E + D Q +Y G V
Sbjct: 647 STRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEY------GAV 700
Query: 686 PNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKLD-------AFIYDAAVLNYK 738
+GST + + ++ M F + ALV + A + ++ + Y
Sbjct: 701 RDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDYALLMESTSIEYV 760
Query: 739 AGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTG 798
R+ C L IG + + GYG+ GSP++ +I +A+LQ +G++ ++ W G
Sbjct: 761 TQRN--CNLTQIGG--LIDSKGYGVGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRG 816
Query: 799 ICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
E++ +S L ++N+ G+F +LAA + LS+ I E ++
Sbjct: 817 NGCPEEDNKEASALGVENIGGIFIVLAAGLVLSVFVAIGEFIY 859
>gi|28605145 glutamate receptor, ionotropic, kainate 3 precursor
[Homo sapiens]
Length = 919
Score = 183 bits (464), Expect = 1e-45
Identities = 175/678 (25%), Positives = 307/678 (45%), Gaps = 98/678 (14%)
Query: 218 QLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGL- 276
++K+ I+ CS A IL +A ++G+ + +I +L +L P + SG+
Sbjct: 220 EMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRY-SGVN 278
Query: 277 -------------ISVSYDDWDYS-LEARVRDGIGILTTAASSMLEKFSYIPEAKASCYG 322
+S + W L+A R G+L + + CY
Sbjct: 279 LTGFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCY- 337
Query: 323 QMERPEVPMHTLH--------------PFMVNVTWDGKD--LSFTE-EGYQVHPRLVVIV 365
P++ +++L F+ W+G + F + G + L +I
Sbjct: 338 -QRAPQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIIS 396
Query: 366 LNKDREWEKVGKWENHT-LSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDP 424
L +D EKVG W L++ R + +D + L + T+ E PFV+ D
Sbjct: 397 LKEDG-LEKVGVWSPADGLNITEVAKGRGPNVTD-SLTNRSLIVTTVLEEPFVMFRKSD- 453
Query: 425 LTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGK 484
R +F +G+CID+LK+L+ + F+Y++ LV +GK
Sbjct: 454 ------RTLYGNDRF-----------------EGYCIDLLKELAHILGFSYEIRLVEDGK 490
Query: 485 HGKKVNN-VWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGT 543
+G + + WNGM+ E++ +A +AV LTI R + +DFS PF+ G+S++ + NGT
Sbjct: 491 YGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGT 550
Query: 544 VSPS--AFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGY--NRNLAKGKAPHGPSF 599
+PS +FL P S +W+ + + L VS + +FV FSP + G +F
Sbjct: 551 -NPSVFSFLNPLSPDIWMYVLLAYLGVSCV-LFVIARFSPYEWYDAHPCNPGSEVVENNF 608
Query: 600 TIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFV 659
T+ + W G + + PK +++I+ +W FF +I ++SYTANLAAF+ E
Sbjct: 609 TLLNSFWFGMGSLMQQGSELM-PKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERME 667
Query: 660 DQVTGLSDKKFQRPHDYSPPFRFGTVPNGST----ERNIRNNYPYMHQYMT-------KF 708
+ D Q +Y G V +G+T +++ + + M +M+ K
Sbjct: 668 SPIDSADDLAKQTKIEY------GAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKN 721
Query: 709 NQKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKG 768
N++G++ AL + A + ++ + Y R+ C L IG + + GYGI G
Sbjct: 722 NEEGIQRALTADY-----ALLMESTTIEYVTQRN--CNLTQIGG--LIDSKGYGIGTPMG 772
Query: 769 SPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAM 828
SP++ +I +A+LQ + ++ ++ W G E+ +S L I + G+F +LAA +
Sbjct: 773 SPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGL 832
Query: 829 ALSLITFIWEHLFYWKLR 846
LS++ + E F +KLR
Sbjct: 833 VLSVLVAVGE--FVYKLR 848
>gi|29029597 glutamate receptor KA2 precursor [Homo sapiens]
Length = 980
Score = 179 bits (454), Expect = 2e-44
Identities = 123/406 (30%), Positives = 207/406 (50%), Gaps = 34/406 (8%)
Query: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGK-KVNNVWNGMIGEVVYQRAVMAVGSLTIN 515
+GFC+D+L++L+ ++F Y L LV +G +G + N W GM+GE++ ++A +AV + TI
Sbjct: 444 EGFCVDMLRELAELLRFRYRLRLVEDGLYGAPEPNGSWTGMVGELINRKADLAVAAFTIT 503
Query: 516 EERSEVVDFSVPFVETGISVM----VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI 571
ER +V+DFS PF+ GIS++ + R G S FL+PFS +VW+ M + L VS +
Sbjct: 504 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPAVWLFMLLAYLAVSCV 560
Query: 572 AVFVFEYFSPV-GYNRNLAKGKAPH--GPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSK 628
+F+ SP YN + PH +T+G ++W G + P+ +++
Sbjct: 561 -LFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWFPVGGFMQQGSEIM-PRALSTR 618
Query: 629 IMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNG 688
+ VW F +I ++SYTANLAAF+ + V D Q +Y GT+ G
Sbjct: 619 CVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLADQTNIEY------GTIHAG 672
Query: 689 STERNIRNNYPYMHQYMTKFNQ--------KGVEDALVSLKTGKLDAFIYDAAVLNYKAG 740
ST +N+ +Q M + Q K E+ + + + AF+ ++ + Y
Sbjct: 673 STMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRY-AFLLESTMNEYH-- 729
Query: 741 RDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGIC 800
R C L IG + T GYGI + GSP++ +I LA+LQ + +E L+ W G
Sbjct: 730 RRLNCNLTQIGG--LLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILKRKWWEGGR 787
Query: 801 HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846
++ + + L ++N+ G+F +L + +++ + E F W R
Sbjct: 788 CPKEEDHRAKGLGMENIGGIFIVLICGLIIAVFVAVME--FIWSTR 831
>gi|167001484 glutamate receptor, ionotropic, AMPA 1 isoform 2 [Homo
sapiens]
Length = 906
Score = 177 bits (450), Expect = 5e-44
Identities = 176/760 (23%), Positives = 330/760 (43%), Gaps = 101/760 (13%)
Query: 140 PTSTFFQFGASIQQQAT-VMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGW 198
P T QF ++ + ++ I+ Y W F + G + T + + W
Sbjct: 114 PVDTSNQFVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKN---W 170
Query: 199 DMQNVITLDTSFEDAKTQVQ-LKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIV 257
+ V L T+ E + Q L+K ++++ C + IL + L G + +I+
Sbjct: 171 QVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYIL 230
Query: 258 PSLVSGNTELIPKEFP------SGLISVSYDD---------WDYS--------------- 287
+L G ++ +F +G V+Y D W S
Sbjct: 231 ANL--GFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKY 288
Query: 288 LEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHT---LHPFMVNVTWD 344
A DG+ ++ A S+ + I + + + P VP + + V ++
Sbjct: 289 TSALTYDGVKVMAEAFQSLRRQRIDISR-RGNAGDCLANPAVPWGQGIDIQRALQQVRFE 347
Query: 345 GK--DLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPD 402
G ++ F E+G + + L VI + D K+G W + A +D +
Sbjct: 348 GLTGNVQFNEKGRRTNYTLHVIEMKHDGI-RKIGYWNEDDKFVPAA--------TDAQAG 398
Query: 403 DNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCID 462
++ S+ I+ED +V + + N+ + +G+C++
Sbjct: 399 GDNSSVQNRTYIVTTILED----------------PYVMLKKNANQFEGNDRY-EGYCVE 441
Query: 463 ILKKLSRTVKFTYDLYLVTNGKHGKKV--NNVWNGMIGEVVYQRAVMAVGSLTINEERSE 520
+ ++++ V ++Y L +V++GK+G + WNGM+GE+VY RA +AV LTI R E
Sbjct: 442 LAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREE 501
Query: 521 VVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYF 579
V+DFS PF+ GIS+M+ + +FL+P + +W M V I ++ +F+ F
Sbjct: 502 VIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRF 560
Query: 580 SPV-GYNRNLAKGK----APHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVW 634
SP ++ +G+ + F I ++W G + +P+ + +I+ VW
Sbjct: 561 SPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVW 619
Query: 635 AFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNI 694
FF +I ++SYTANLAAF+ E V + D Q +GT+ GST+
Sbjct: 620 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLEAGSTKEFF 673
Query: 695 RNN--------YPYMHQYMTKFNQKGVEDALVSLKTGK-LDAFIYDAAVLNYKAGRDEGC 745
R + + YM + E+ ++ ++ K A++ ++ + Y R + C
Sbjct: 674 RRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQR-KPC 732
Query: 746 KLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL--TGICHNE 803
+ +G + GYGIA KGS + ++LA+L+ G +++L++ W G C ++
Sbjct: 733 DTMKVGGN--LDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSK 790
Query: 804 K--NEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
++ +S L + N+AGVFY+L + L+++ + E +
Sbjct: 791 DSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCY 830
>gi|163659856 glutamate receptor, ionotrophic, AMPA 3 isoform 1
precursor [Homo sapiens]
Length = 894
Score = 177 bits (448), Expect = 9e-44
Identities = 125/411 (30%), Positives = 207/411 (50%), Gaps = 40/411 (9%)
Query: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTI 514
+G+C+D+ ++++ V+ Y L +V +GK+G + +WNGM+GE+VY RA +AV LTI
Sbjct: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 515 NEERSEVVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAV 573
R EV+DFS PF+ GIS+M+ + +FL+P + +W M V I ++ +
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
Query: 574 FVFEYFSPVGYN--RNLAKGKAPHGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKGTT 626
F+ FSP ++ N + + P P F I ++W G + +P+ +
Sbjct: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
Query: 627 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVP 686
+I+ VW FF +I ++SYTANLAAF+ E V + D Q +GT+
Sbjct: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
Query: 687 NGSTERNIRNN----YPYMHQYM--------TKFNQKGVEDALVSLKTGKLDAFIYDAAV 734
+GST+ R + Y M YM TK GV A V GK AF+ ++ +
Sbjct: 684 SGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV--ARVRKSKGKF-AFLLESTM 740
Query: 735 LNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETL 794
Y R + C + +G + GYG+A KGS ++LA+L+ G +++L+
Sbjct: 741 NEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLKNK 797
Query: 795 WL--TGIC--HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
W G C + ++ +S L + N+AGVFY+L + L+++ + E +
Sbjct: 798 WWYDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
>gi|29029595 glutamate receptor KA1 precursor [Homo sapiens]
Length = 956
Score = 176 bits (446), Expect = 1e-43
Identities = 125/446 (28%), Positives = 218/446 (48%), Gaps = 47/446 (10%)
Query: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHG-KKVNNVWNGMIGEVVYQRAVMAVGSLTIN 515
+GFC+D+LK+L+ ++F Y + LV +G +G + N W GM+GE++ ++A +AV LTI
Sbjct: 445 EGFCVDMLKELAEILRFNYKIRLVGDGVYGVPEANGTWTGMVGELIARKADLAVAGLTIT 504
Query: 516 EERSEVVDFSVPFVETGISVM----VSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAI 571
ER +V+DFS PF+ GIS++ + R G S FL+PFS VW+ M + L VS +
Sbjct: 505 AEREKVIDFSKPFMTLGISILYRVHMGRKPGYFS---FLDPFSPGVWLFMLLAYLAVSCV 561
Query: 572 AVFV-----FEYFSPVGYNRNLAKGKAP-HGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT 625
V +E++SP A+G+ +++G ++W G + P+
Sbjct: 562 LFLVARLTPYEWYSP----HPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIA-PRAL 616
Query: 626 TSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTV 685
+++ + VW F +I ++SYTANLAAF+ + + + D Q +Y GT+
Sbjct: 617 STRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEY------GTI 670
Query: 686 PNGSTERNIRNN--------YPYMHQYMTKFNQKGVEDALVSLKTGKLDAFIYDAAVLNY 737
GS+ +N+ + YM+ K E+ + + AF+ ++ + Y
Sbjct: 671 HGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNY-AFLLESTMNEY 729
Query: 738 KAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLT 797
R C L IG + T GYGI + GS ++ + DLA+LQ + +E L+ W
Sbjct: 730 Y--RQRNCNLTQIGG--LLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILKRKWWE 785
Query: 798 GICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRF---CFTGVCS 854
G ++ + + L ++N+ G+F +L + +++ + E F W LR VC
Sbjct: 786 GGKCPKEEDHRAKGLGMENIGGIFVVLICGLIVAIFMAMLE--FLWTLRHSEATEVSVCQ 843
Query: 855 DRPGLLFSISRGIYSCIHGVHIEEKK 880
+ + + R I C +H ++
Sbjct: 844 E----MVTELRSIILCQDSIHPRRRR 865
>gi|163659858 glutamate receptor, ionotrophic, AMPA 3 isoform 2
precursor [Homo sapiens]
Length = 894
Score = 176 bits (446), Expect = 1e-43
Identities = 125/411 (30%), Positives = 207/411 (50%), Gaps = 40/411 (9%)
Query: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKK--VNNVWNGMIGEVVYQRAVMAVGSLTI 514
+G+C+D+ ++++ V+ Y L +V +GK+G + +WNGM+GE+VY RA +AV LTI
Sbjct: 452 EGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTI 511
Query: 515 NEERSEVVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAV 573
R EV+DFS PF+ GIS+M+ + +FL+P + +W M V I ++ +
Sbjct: 512 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 570
Query: 574 FVFEYFSPVGYN--RNLAKGKAPHGP-----SFTIGKAIWLLWGLVFNNSVPVQNPKGTT 626
F+ FSP ++ N + + P P F I ++W G + +P+ +
Sbjct: 571 FLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLS 629
Query: 627 SKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVP 686
+I+ VW FF +I ++SYTANLAAF+ E V + D Q +GT+
Sbjct: 630 GRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLD 683
Query: 687 NGSTERNIRNN----YPYMHQYM--------TKFNQKGVEDALVSLKTGKLDAFIYDAAV 734
+GST+ R + Y M YM TK GV A V GK AF+ ++ +
Sbjct: 684 SGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGV--ARVRKSKGKF-AFLLESTM 740
Query: 735 LNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETL 794
Y R + C + +G + GYG+A KGS ++LA+L+ G +++L+
Sbjct: 741 NEYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNK 797
Query: 795 WL--TGICHN--EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
W G C + ++ +S L + N+AGVFY+L + L+++ + E +
Sbjct: 798 WWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCY 848
>gi|167001419 glutamate receptor, ionotropic, AMPA 1 isoform 1 [Homo
sapiens]
Length = 906
Score = 176 bits (446), Expect = 1e-43
Identities = 176/760 (23%), Positives = 328/760 (43%), Gaps = 101/760 (13%)
Query: 140 PTSTFFQFGASIQQQAT-VMLKIMQDYDWHVFSLVTTIFPGYREFISFVKTTVDNSFVGW 198
P T QF ++ + ++ I+ Y W F + G + T + + W
Sbjct: 114 PVDTSNQFVLQLRPELQDALISIIDHYKWQKFVYIYDADRGLSVLQKVLDTAAEKN---W 170
Query: 199 DMQNVITLDTSFEDAKTQVQ-LKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIV 257
+ V L T+ E + Q L+K ++++ C + IL + L G + +I+
Sbjct: 171 QVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIIKLEKNGIGYHYIL 230
Query: 258 PSLVSGNTELIPKEFP------SGLISVSYDD---------WDYS--------------- 287
+L G ++ +F +G V+Y D W S
Sbjct: 231 ANL--GFMDIDLNKFKESGANVTGFQLVNYTDTIPAKIMQQWKNSDARDHTRVDWKRPKY 288
Query: 288 LEARVRDGIGILTTAASSMLEKFSYIPEAKASCYGQMERPEVPMHT---LHPFMVNVTWD 344
A DG+ ++ A S+ + I + + + P VP + + V ++
Sbjct: 289 TSALTYDGVKVMAEAFQSLRRQRIDISR-RGNAGDCLANPAVPWGQGIDIQRALQQVRFE 347
Query: 345 GK--DLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENHTLSLRHAVWPRYKSFSDCEPD 402
G ++ F E+G + + L VI + D K+G W + A +D +
Sbjct: 348 GLTGNVQFNEKGRRTNYTLHVIEMKHDGI-RKIGYWNEDDKFVPAA--------TDAQAG 398
Query: 403 DNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCID 462
++ S+ I+ED +V + + N+ + +G+C++
Sbjct: 399 GDNSSVQNRTYIVTTILED----------------PYVMLKKNANQFEGNDRY-EGYCVE 441
Query: 463 ILKKLSRTVKFTYDLYLVTNGKHGKKV--NNVWNGMIGEVVYQRAVMAVGSLTINEERSE 520
+ ++++ V ++Y L +V++GK+G + WNGM+GE+VY RA +AV LTI R E
Sbjct: 442 LAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREE 501
Query: 521 VVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYF 579
V+DFS PF+ GIS+M+ + +FL+P + +W M V I ++ +F+ F
Sbjct: 502 VIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRF 560
Query: 580 SPV-GYNRNLAKGK----APHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVW 634
SP ++ +G+ + F I ++W G + +P+ + +I+ VW
Sbjct: 561 SPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSGRIVGGVW 619
Query: 635 AFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNI 694
FF +I ++SYTANLAAF+ E V + D Q +GT+ GST+
Sbjct: 620 WFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLEAGSTKEFF 673
Query: 695 RNN--------YPYMHQYMTKFNQKGVEDALVSLKTGK-LDAFIYDAAVLNYKAGRDEGC 745
R + + YM + E+ ++ ++ K A++ ++ + Y R + C
Sbjct: 674 RRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQR-KPC 732
Query: 746 KLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWL--TGICHN- 802
+ +G + GYGIA KGS + ++LA+L+ G +++L+ W G C +
Sbjct: 733 DTMKVGGN--LDSKGYGIATPKGSALRNPVNLAVLKLNEQGLLDKLKNKWWYDKGECGSG 790
Query: 803 -EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
++ +S L + N+AGVFY+L + L+++ + E +
Sbjct: 791 GGDSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCY 830
>gi|157384977 glutamate receptor, ionotropic, delta 2 [Homo sapiens]
Length = 1007
Score = 173 bits (439), Expect = 1e-42
Identities = 187/758 (24%), Positives = 320/758 (42%), Gaps = 122/758 (16%)
Query: 157 VMLKIMQDYDWHVFSLVTTI---FPGYREFISFVKTTVDNSFVGWDMQNVITLDTSFEDA 213
V+L+++ +Y W F + G +EF+ V + + N+ + T+ D
Sbjct: 155 VILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDT 214
Query: 214 KTQVQLKKIHSSV--ILLYCSKDEAVLILSEARSLGLTGYDFFWI----------VPSLV 261
+L + ++ +L + A ++E L +D WI V LV
Sbjct: 215 MRIEELNRYRDTLRRAILVMNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELV 274
Query: 262 S---GNTELIPKEFP----------------SGLISVSYDDWDYSLEAR---VRDGIGIL 299
G +I + FP S + D + ++E + D + +L
Sbjct: 275 RRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSTLCDPKDPFAQNMEISNLYIYDTVLLL 334
Query: 300 TTAASSMLEKFSYIPEAKASCYGQMERPEVPMHTLHPFMVNVTWDGK--DLSFTEEGYQV 357
A LE + A SC + +P ++ + G +L F E G
Sbjct: 335 ANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLETIKKGGVSGLTGELEFGENGGNP 394
Query: 358 HPRLVVIVLNKDREW----EKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNH----LSIV 409
+ ++ N E K+G W + V S +D + ++N L +V
Sbjct: 395 NVHFEILGTNYGEELGRGVRKLGCW--------NPVTGLNGSLTDKKLENNMRGVVLRVV 446
Query: 410 TLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSR 469
T+ E PFV+V + + K +GF ID+L LS
Sbjct: 447 TVLEEPFVMVSE--------------------------NVLGKPKKYQGFSIDVLDALSN 480
Query: 470 TVKFTYDLYLVTNGKHGK-KVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPF 528
+ F Y++Y+ + K+G + + WNG++GE+V++RA + + +LTI +R VVDF+ +
Sbjct: 481 YLGFNYEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRY 540
Query: 529 VETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNL 588
++ + V++ R+ TV A L PF S+W + +L+V + V++ + +P L
Sbjct: 541 MDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVLLV-GLLVYLLNWLNP----PRL 595
Query: 589 AKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGT-TSKIMVSVWAFFAVIFLASYTA 647
G S T+ ++W ++G V P T +++M+ W FA+I ++SYTA
Sbjct: 596 QMGSM---TSTTLYNSMWFVYGSFVQQGGEV--PYTTLATRMMMGAWWLFALIVISSYTA 650
Query: 648 NLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR----------NN 697
NLAAF+ + L D Q Y GTV + + ++R +
Sbjct: 651 NLAAFLTITRIESSIQSLQDLSKQTEIPY------GTVLDSAVYEHVRMKGLNPFERDSM 704
Query: 698 YPYMHQYMTKFN--QKGVEDALVSLKTGKLD--AFIYDAAVLNYKAGRDEGCKLVTIGSG 753
Y M + + + N + V ++ ++ K AF++DAAVL Y A D C TIG+
Sbjct: 705 YSQMWRMINRSNGSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGN- 763
Query: 754 YIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLW--LTGIC---HNEKNEVM 808
A GYGIALQ GSP++ +L+ +G+M+ L+ W G C + +
Sbjct: 764 -TVADRGYGIALQHGSPYRDVFSQRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQK 822
Query: 809 SSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLR 846
LDI + AGVF +LAA + LS + E +W R
Sbjct: 823 GGALDIKSFAGVFCILAAGIVLSCFIAMLE--TWWNKR 858
>gi|164419734 glutamate receptor, ionotrophic, AMPA 4 isoform 1
precursor [Homo sapiens]
Length = 902
Score = 172 bits (436), Expect = 2e-42
Identities = 120/410 (29%), Positives = 206/410 (50%), Gaps = 40/410 (9%)
Query: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV--NNVWNGMIGEVVYQRAVMAVGSLTI 514
+G+C+D+ ++++ + Y + +V +GK+G + +WNGM+GE+VY +A +A+ LTI
Sbjct: 444 EGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTI 503
Query: 515 NEERSEVVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAV 573
R EV+DFS PF+ GIS+M+ + +FL+P + +W M V I ++ +
Sbjct: 504 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 562
Query: 574 FVFEYFSPVGYNRNLAKGKAPHGPS------FTIGKAIWLLWGLVFNNSVPVQNPKGTTS 627
F+ FSP ++ + GPS F I ++W G + +P+ +
Sbjct: 563 FLVSRFSPYEWHTEEPE-DGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSG 620
Query: 628 KIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPN 687
+I+ VW FF +I ++SYTANLAAF+ E V + D Q +GT+ +
Sbjct: 621 RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLDS 674
Query: 688 GSTERNIRNN----YPYMHQYM--------TKFNQKGVEDALVSLKTGKLDAFIYDAAVL 735
GST+ R + Y M YM T+ +GV A V GK AF+ ++ +
Sbjct: 675 GSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGV--ARVRKSKGKF-AFLLESTMN 731
Query: 736 NYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLW 795
Y R + C + +G + GYG+A KGS ++LA+L+ G +++L+ W
Sbjct: 732 EYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSSLGTPVNLAVLKLSEAGVLDKLKNKW 788
Query: 796 L--TGIC--HNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
G C + ++ +S L + N+AGVFY+L + L+++ + E +
Sbjct: 789 WYDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 838
>gi|134304851 glutamate receptor, ionotropic, AMPA 2 isoform 3 [Homo
sapiens]
Length = 836
Score = 172 bits (435), Expect = 3e-42
Identities = 172/676 (25%), Positives = 308/676 (45%), Gaps = 68/676 (10%)
Query: 207 DTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTE 266
D + ++LKK ++L C +D+ I+ + ++G + +I+ +L + +
Sbjct: 142 DEMYRSLFQDLELKKERR--VILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGD 199
Query: 267 LIPKEFP----SGLISVSYDD---------WDYSLEARVRDGIGILTTAASSMLEKFSYI 313
L+ +F SG V YDD W +LE + G T +S L +
Sbjct: 200 LLKIQFGGANVSGFQIVDYDDSLVSKFIERWS-TLEEKEYPGAHTTTIKYTSALTYDAVQ 258
Query: 314 PEAKASCYGQMERPEVPMH-TLHPFMVN--VTWDGKDLSFTEEGYQVHPRLVVIVLNKDR 370
+A + +R E+ + N V W G+ + QV V L+ +
Sbjct: 259 VMTEAFRNLRKQRIEISRRGNAGDCLANPAVPW-GQGVEIERALKQVQ----VEGLSGNI 313
Query: 371 EWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPL-TETC 429
++++ GK N+T+++ + D +VTL E P D L +T
Sbjct: 314 KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDK--MVVTLTELPSG--NDTSGLENKTV 369
Query: 430 VRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV 489
V T+ +V + + +E + + +G+C+D+ ++++ F Y L +V +GK+G +
Sbjct: 370 VVTTILESPYVMMKKN-HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 428
Query: 490 --NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSR-SNGTVSP 546
+WNGM+GE+VY +A +A+ LTI R EV+DFS PF+ GIS+M+ +
Sbjct: 429 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 488
Query: 547 SAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYN-RNLAKGKAPHGP----SFTI 601
+FL+P + +W M V I ++ +F+ FSP ++ G+ F I
Sbjct: 489 FSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGI 547
Query: 602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 661
++W G + +P+ + +I+ VW FF +I ++SYTANLAAF+ E V
Sbjct: 548 FNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 606
Query: 662 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNN----YPYMHQYM--------TKFN 709
+ D Q +GT+ +GST+ R + + M YM +
Sbjct: 607 IESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTT 660
Query: 710 QKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGS 769
+GV A V GK A++ ++ + Y R + C + +G + GYGIA KGS
Sbjct: 661 AEGV--ARVRKSKGKY-AYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGS 714
Query: 770 PWKRQIDLALLQFVGDGEMEELETLWL--TGIC--HNEKNEVMSSQLDIDNMAGVFYMLA 825
+ ++LA+L+ G +++L+ W G C + ++ +S L + N+AGVFY+L
Sbjct: 715 SLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILV 774
Query: 826 AAMALSLITFIWEHLF 841
+ L+++ + E +
Sbjct: 775 GGLGLAMLVALIEFCY 790
>gi|74275354 glutamate receptor, ionotropic, AMPA 2 isoform 1
precursor [Homo sapiens]
Length = 883
Score = 172 bits (435), Expect = 3e-42
Identities = 172/676 (25%), Positives = 308/676 (45%), Gaps = 68/676 (10%)
Query: 207 DTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTE 266
D + ++LKK ++L C +D+ I+ + ++G + +I+ +L + +
Sbjct: 189 DEMYRSLFQDLELKKERR--VILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGD 246
Query: 267 LIPKEFP----SGLISVSYDD---------WDYSLEARVRDGIGILTTAASSMLEKFSYI 313
L+ +F SG V YDD W +LE + G T +S L +
Sbjct: 247 LLKIQFGGANVSGFQIVDYDDSLVSKFIERWS-TLEEKEYPGAHTTTIKYTSALTYDAVQ 305
Query: 314 PEAKASCYGQMERPEVPMH-TLHPFMVN--VTWDGKDLSFTEEGYQVHPRLVVIVLNKDR 370
+A + +R E+ + N V W G+ + QV V L+ +
Sbjct: 306 VMTEAFRNLRKQRIEISRRGNAGDCLANPAVPW-GQGVEIERALKQVQ----VEGLSGNI 360
Query: 371 EWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPL-TETC 429
++++ GK N+T+++ + D +VTL E P D L +T
Sbjct: 361 KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDK--MVVTLTELPSG--NDTSGLENKTV 416
Query: 430 VRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV 489
V T+ +V + + +E + + +G+C+D+ ++++ F Y L +V +GK+G +
Sbjct: 417 VVTTILESPYVMMKKN-HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475
Query: 490 --NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSR-SNGTVSP 546
+WNGM+GE+VY +A +A+ LTI R EV+DFS PF+ GIS+M+ +
Sbjct: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535
Query: 547 SAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYN-RNLAKGKAPHGP----SFTI 601
+FL+P + +W M V I ++ +F+ FSP ++ G+ F I
Sbjct: 536 FSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGI 594
Query: 602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 661
++W G + +P+ + +I+ VW FF +I ++SYTANLAAF+ E V
Sbjct: 595 FNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 653
Query: 662 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNN----YPYMHQYM--------TKFN 709
+ D Q +GT+ +GST+ R + + M YM +
Sbjct: 654 IESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTT 707
Query: 710 QKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGS 769
+GV A V GK A++ ++ + Y R + C + +G + GYGIA KGS
Sbjct: 708 AEGV--ARVRKSKGKY-AYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGS 761
Query: 770 PWKRQIDLALLQFVGDGEMEELETLWL--TGIC--HNEKNEVMSSQLDIDNMAGVFYMLA 825
+ ++LA+L+ G +++L+ W G C + ++ +S L + N+AGVFY+L
Sbjct: 762 SLRTPVNLAVLKLSEQGVLDKLKNKWWYDKGECGAKDSGSKEKTSALSLSNVAGVFYILV 821
Query: 826 AAMALSLITFIWEHLF 841
+ L+++ + E +
Sbjct: 822 GGLGLAMLVALIEFCY 837
>gi|164419736 glutamate receptor, ionotrophic, AMPA 4 isoform 2
precursor [Homo sapiens]
Length = 884
Score = 172 bits (435), Expect = 3e-42
Identities = 120/410 (29%), Positives = 206/410 (50%), Gaps = 40/410 (9%)
Query: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV--NNVWNGMIGEVVYQRAVMAVGSLTI 514
+G+C+D+ ++++ + Y + +V +GK+G + +WNGM+GE+VY +A +A+ LTI
Sbjct: 444 EGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTI 503
Query: 515 NEERSEVVDFSVPFVETGISVMVSR-SNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAV 573
R EV+DFS PF+ GIS+M+ + +FL+P + +W M V I ++ +
Sbjct: 504 TLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIW-MCIVFAYIGVSVVL 562
Query: 574 FVFEYFSPVGYNRNLAKGKAPHGPS------FTIGKAIWLLWGLVFNNSVPVQNPKGTTS 627
F+ FSP ++ + GPS F I ++W G + +P+ +
Sbjct: 563 FLVSRFSPYEWHTEEPE-DGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDI-SPRSLSG 620
Query: 628 KIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPN 687
+I+ VW FF +I ++SYTANLAAF+ E V + D Q +GT+ +
Sbjct: 621 RIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQ------TEIAYGTLDS 674
Query: 688 GSTERNIRNN----YPYMHQYM--------TKFNQKGVEDALVSLKTGKLDAFIYDAAVL 735
GST+ R + Y M YM T+ +GV A V GK AF+ ++ +
Sbjct: 675 GSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGV--ARVRKSKGKF-AFLLESTMN 731
Query: 736 NYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLW 795
Y R + C + +G + GYG+A KGS ++LA+L+ G +++L+ W
Sbjct: 732 EYIEQR-KPCDTMKVGGN--LDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKW 788
Query: 796 L--TGICHN--EKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLF 841
G C + ++ +S L + N+AGVFY+L + L+++ + E +
Sbjct: 789 WYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCY 838
>gi|134304848 glutamate receptor, ionotropic, AMPA 2 isoform 2
precursor [Homo sapiens]
Length = 883
Score = 171 bits (432), Expect = 6e-42
Identities = 172/676 (25%), Positives = 308/676 (45%), Gaps = 68/676 (10%)
Query: 207 DTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTE 266
D + ++LKK ++L C +D+ I+ + ++G + +I+ +L + +
Sbjct: 189 DEMYRSLFQDLELKKERR--VILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGD 246
Query: 267 LIPKEFP----SGLISVSYDD---------WDYSLEARVRDGIGILTTAASSMLEKFSYI 313
L+ +F SG V YDD W +LE + G T +S L +
Sbjct: 247 LLKIQFGGANVSGFQIVDYDDSLVSKFIERWS-TLEEKEYPGAHTTTIKYTSALTYDAVQ 305
Query: 314 PEAKASCYGQMERPEVPMH-TLHPFMVN--VTWDGKDLSFTEEGYQVHPRLVVIVLNKDR 370
+A + +R E+ + N V W G+ + QV V L+ +
Sbjct: 306 VMTEAFRNLRKQRIEISRRGNAGDCLANPAVPW-GQGVEIERALKQVQ----VEGLSGNI 360
Query: 371 EWEKVGKWENHTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPL-TETC 429
++++ GK N+T+++ + D +VTL E P D L +T
Sbjct: 361 KFDQNGKRINYTINIMELKTNGPRKIGYWSEVDK--MVVTLTELPSG--NDTSGLENKTV 416
Query: 430 VRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKV 489
V T+ +V + + +E + + +G+C+D+ ++++ F Y L +V +GK+G +
Sbjct: 417 VVTTILESPYVMMKKN-HEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARD 475
Query: 490 --NNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSR-SNGTVSP 546
+WNGM+GE+VY +A +A+ LTI R EV+DFS PF+ GIS+M+ +
Sbjct: 476 ADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGV 535
Query: 547 SAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYN-RNLAKGKAPHGP----SFTI 601
+FL+P + +W M V I ++ +F+ FSP ++ G+ F I
Sbjct: 536 FSFLDPLAYEIW-MCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGI 594
Query: 602 GKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQ 661
++W G + +P+ + +I+ VW FF +I ++SYTANLAAF+ E V
Sbjct: 595 FNSLWFSLGAFMRQGCDI-SPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSP 653
Query: 662 VTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNN----YPYMHQYM--------TKFN 709
+ D Q +GT+ +GST+ R + + M YM +
Sbjct: 654 IESAEDLSKQ------TEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTT 707
Query: 710 QKGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGS 769
+GV A V GK A++ ++ + Y R + C + +G + GYGIA KGS
Sbjct: 708 AEGV--ARVRKSKGKY-AYLLESTMNEYIEQR-KPCDTMKVGGN--LDSKGYGIATPKGS 761
Query: 770 PWKRQIDLALLQFVGDGEMEELETLWL--TGICHN--EKNEVMSSQLDIDNMAGVFYMLA 825
+ ++LA+L+ G +++L+ W G C + ++ +S L + N+AGVFY+L
Sbjct: 762 SLRNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILV 821
Query: 826 AAMALSLITFIWEHLF 841
+ L+++ + E +
Sbjct: 822 GGLGLAMLVALIEFCY 837
>gi|55770852 glutamate receptor, ionotropic, delta 1 precursor [Homo
sapiens]
Length = 1009
Score = 162 bits (410), Expect = 2e-39
Identities = 111/412 (26%), Positives = 195/412 (47%), Gaps = 35/412 (8%)
Query: 457 KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNV-WNGMIGEVVYQRAVMAVGSLTIN 515
KGF ID+L L++ + F Y++Y +G++G +++N WNGMIGE++ +RA +A+ ++TI
Sbjct: 464 KGFSIDVLDALAKALGFKYEIYQAPDGRYGHQLHNTSWNGMIGELISKRADLAISAITIT 523
Query: 516 EERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFV 575
ER VVDFS +++ + +++ + +S + PF +VW + + +V + +FV
Sbjct: 524 PERESVVDFSKRYMDYSVGILIKKPEEKISIFSLFAPFDFAVWACIAAAIPVV-GVLIFV 582
Query: 576 FEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWA 635
V R + + S T+ AIW+++G F + +I++ W
Sbjct: 583 LNRIQAV---RAQSAAQPRPSASATLHSAIWIVYG-AFVQQGGESSVNSMAMRIVMGSWW 638
Query: 636 FFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIR 695
F +I +SYTANLAAF+ + + D Q Y GTV + + R
Sbjct: 639 LFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQVEMSY------GTVRDSAVYEYFR 692
Query: 696 --------NNYPYMHQYMTKFNQKGVEDALVSLKTGKLD------AFIYDAAVLNYKAGR 741
+ + + T G ++ + S G AF++D AV+ Y A
Sbjct: 693 AKGTNPLEQDSTFAELWRTISKNGGADNCVSSPSEGIRKAKKGNYAFLWDVAVVEYAALT 752
Query: 742 DEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICH 801
D+ C + IG+ ++ GYGIALQ GSP++ +L+ G+++ L+ W +
Sbjct: 753 DDDCSVTVIGNS--ISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQKWWPHMGR 810
Query: 802 NEKNEVMSSQLD-----IDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFC 848
+ S+Q D + + AGVF +LA + L+ + E +W C
Sbjct: 811 CDLTSHASAQADGKSLKLHSFAGVFCILAIGLLLACLVAALE--LWWNSNRC 860
>gi|50845418 WNK lysine deficient protein kinase 3 isoform 1 [Homo
sapiens]
Length = 1800
Score = 38.1 bits (87), Expect = 0.063
Identities = 41/194 (21%), Positives = 73/194 (37%), Gaps = 16/194 (8%)
Query: 916 DSPKRAADFIQRGSLIMDMVSDKGNLMYSDNRSFQGKESIFGDNMNELQTFVANRQKDNL 975
D+P+ AD++ + +++ +K + +I G L A + +
Sbjct: 780 DAPEDIADYMVEDNFVLESEKEK---------FVEELRAIVGQAQEILHVHFATERATGV 830
Query: 976 NNYVFQGQHPLTLNESNP--NTVEVAVSTESKANSRPRQLWKKSVDSIRQDSLSQNPVSQ 1033
++ T + N+ S ES S P W+ ++ ++ +Q+P S
Sbjct: 831 DSITVDSNSSQTGSSEQVQINSTSTQTSNESAPQSSPVGRWRFCINQTIRNRETQSPPSL 890
Query: 1034 RDEATAENRTHSLKSPRYLPEEMAHSDISETSNRATCHREPDNSKN-HKTKDNFK----R 1088
+ +A H L SP+ + D T CHR SK+ HK + K
Sbjct: 891 QHSMSAVPGRHPLPSPKNTSNKEISRDTLLTIENNPCHRALFTSKSEHKDVVDGKISECA 950
Query: 1089 SVASKYPKDCSEVE 1102
SV +K P +VE
Sbjct: 951 SVETKQPAILYQVE 964
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 55,621,259
Number of Sequences: 37866
Number of extensions: 2540140
Number of successful extensions: 7078
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 32
Number of HSP's successfully gapped in prelim test: 34
Number of HSP's that attempted gapping in prelim test: 6848
Number of HSP's gapped (non-prelim): 120
length of query: 1464
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1349
effective length of database: 13,892,928
effective search space: 18741559872
effective search space used: 18741559872
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.