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Search of human proteins with 197304744
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
(456 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197304744 RUN domain containing 3B isoform b [Homo sapiens] 903 0.0
gi|19923090 RUN domain containing 3B isoform a [Homo sapiens] 892 0.0
gi|197304746 RUN domain containing 3B isoform c [Homo sapiens] 779 0.0
gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens] 443 e-124
gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens] 405 e-113
gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens] 399 e-111
gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo sa... 123 3e-28
gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo sa... 119 7e-27
gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo sapi... 118 1e-26
gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo sap... 118 1e-26
gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo sap... 113 3e-25
gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo sap... 105 9e-23
gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo sap... 105 9e-23
gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo sa... 89 6e-18
gi|116292170 RUN domain containing 2A [Homo sapiens] 62 8e-10
gi|221139728 pleckstrin homology domain containing, family M (wi... 47 5e-05
gi|122891862 DENN/MADD domain containing 5B [Homo sapiens] 47 5e-05
gi|44889475 RAB6 interacting protein 1 [Homo sapiens] 45 2e-04
gi|40538728 pleckstrin homology domain containing, family M (wit... 42 0.002
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 38 0.022
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 38 0.022
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 37 0.037
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 37 0.049
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 37 0.049
gi|16306548 seryl-tRNA synthetase [Homo sapiens] 36 0.083
gi|31982906 cingulin-like 1 [Homo sapiens] 35 0.11
gi|5032281 dystrophin Dp427c isoform [Homo sapiens] 35 0.18
gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens] 35 0.18
gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens] 35 0.18
gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens] 35 0.18
>gi|197304744 RUN domain containing 3B isoform b [Homo sapiens]
Length = 456
Score = 903 bits (2334), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS 60
MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS
Sbjct: 1 MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS 60
Query: 61 PEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSS 120
PEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSS
Sbjct: 61 PEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSS 120
Query: 121 SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAI 180
SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAI
Sbjct: 121 SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAI 180
Query: 181 DFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPP 240
DFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPP
Sbjct: 181 DFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPP 240
Query: 241 FLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLA 300
FLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLA
Sbjct: 241 FLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLA 300
Query: 301 HKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYR 360
HKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYR
Sbjct: 301 HKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYR 360
Query: 361 KHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLC 420
KHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLC
Sbjct: 361 KHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLC 420
Query: 421 GSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS 456
GSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS
Sbjct: 421 GSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS 456
>gi|19923090 RUN domain containing 3B isoform a [Homo sapiens]
Length = 473
Score = 892 bits (2306), Expect = 0.0
Identities = 456/473 (96%), Positives = 456/473 (96%), Gaps = 17/473 (3%)
Query: 1 MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS 60
MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS
Sbjct: 1 MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS 60
Query: 61 PEFNNFAAILEQILSHRLK-----------------GQVTWFGYESPRSFWDYIRVACRK 103
PEFNNFAAILEQILSHRLK GQVTWFGYESPRSFWDYIRVACRK
Sbjct: 61 PEFNNFAAILEQILSHRLKEISQSCRWLAHLQIPLQGQVTWFGYESPRSFWDYIRVACRK 120
Query: 104 VSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVL 163
VSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVL
Sbjct: 121 VSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVL 180
Query: 164 GEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRT 223
GEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRT
Sbjct: 181 GEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRT 240
Query: 224 LGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSES 283
LGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSES
Sbjct: 241 LGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSES 300
Query: 284 VSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPS 343
VSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPS
Sbjct: 301 VSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPS 360
Query: 344 PGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTL 403
PGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTL
Sbjct: 361 PGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTL 420
Query: 404 NVMSEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS 456
NVMSEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS
Sbjct: 421 NVMSEGKEDTPSLLGLCGSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS 473
>gi|197304746 RUN domain containing 3B isoform c [Homo sapiens]
Length = 407
Score = 779 bits (2011), Expect = 0.0
Identities = 407/456 (89%), Positives = 407/456 (89%), Gaps = 49/456 (10%)
Query: 1 MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS 60
MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS
Sbjct: 1 MASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSS 60
Query: 61 PEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSS 120
PEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSS
Sbjct: 61 PEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSS 120
Query: 121 SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAI 180
SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAI
Sbjct: 121 SRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAI 180
Query: 181 DFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPP 240
DFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPP
Sbjct: 181 DFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPP 240
Query: 241 FLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLA 300
FLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLA
Sbjct: 241 FLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLA 300
Query: 301 HKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYR 360
HKLEKEQLEYIIVELQDQL
Sbjct: 301 HKLEKEQLEYIIVELQDQL----------------------------------------- 319
Query: 361 KHNKQWYEKSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLC 420
KSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLC
Sbjct: 320 --------KSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLC 371
Query: 421 GSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS 456
GSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS
Sbjct: 372 GSLTSVASYKSLTSLKSNDYLASPTTEMTSPGLTPS 407
>gi|221307578 RUN domain containing 3A isoform 1 [Homo sapiens]
Length = 446
Score = 443 bits (1140), Expect = e-124
Identities = 244/448 (54%), Positives = 316/448 (70%), Gaps = 23/448 (5%)
Query: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
Query: 78 LK-----GQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVA 132
K G V+WF + R FWDYIR+AC KV NC+ SIENMEN+S++RAKGRAWIRVA
Sbjct: 73 FKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVA 132
Query: 133 LMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLD 192
LMEK +SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AIDFSFCLKGE LD
Sbjct: 133 LMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLD 192
Query: 193 GSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKC 252
G P VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P + DE+SW++K
Sbjct: 193 GKTPVVIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKW 251
Query: 253 KRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYII 312
+++QK+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++ ++ EK +LE +I
Sbjct: 252 HKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVI 311
Query: 313 VELQDQLTVLKNND----LRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYE 368
+ELQ+QLT L +D + +ELT L NQWPS G L+ A ++ LYR+H
Sbjct: 312 LELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRH------ 365
Query: 369 KSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCGSLTSVAS 428
S+ S + LSAE SLS S + G+G +D GK+ TPS+LGLCGSL S+ S
Sbjct: 366 -SFMSTEPLSAEASLSSDS-----QRLGEGTRDEEPWGPIGKDPTPSMLGLCGSLASIPS 419
Query: 429 YKSLTSLKSNDYLASPTTEMTSPGLTPS 456
KSL S KSN+ L S + E SP L+PS
Sbjct: 420 CKSLASFKSNECLVSDSPE-GSPALSPS 446
>gi|221307580 RUN domain containing 3A isoform 3 [Homo sapiens]
Length = 400
Score = 405 bits (1040), Expect = e-113
Identities = 215/388 (55%), Positives = 281/388 (72%), Gaps = 17/388 (4%)
Query: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
Query: 78 LKGQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKH 137
KG V+WF + R FWDYIR+AC KV NC+ SIENMEN+S++RAKGRAWIRVALMEK
Sbjct: 73 FKGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVALMEKR 132
Query: 138 LSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPA 197
+SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AIDFSFCLKGE LDG P
Sbjct: 133 MSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLDGKTPV 192
Query: 198 VIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQ 257
VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P + DE+SW++K +++Q
Sbjct: 193 VIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKWHKMEQ 251
Query: 258 KYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQD 317
K+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++ ++ EK +LE +I+ELQ+
Sbjct: 252 KFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVILELQE 311
Query: 318 QLTVLKNND----LRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQS 373
QLT L +D + +ELT L NQWPS G L+ A ++ LYR+H S+ S
Sbjct: 312 QLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRH-------SFMS 364
Query: 374 LDQLSAEVSLSQTSLDPGQSQEGDGKQD 401
+ LSAE SLS S + G+G +D
Sbjct: 365 TEPLSAEASLSSDS-----QRLGEGTRD 387
>gi|5730015 RUN domain containing 3A isoform 2 [Homo sapiens]
Length = 405
Score = 399 bits (1024), Expect = e-111
Identities = 215/393 (54%), Positives = 281/393 (71%), Gaps = 22/393 (5%)
Query: 18 GGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHR 77
G K S+RN AVER+NLITVCRFSVKTL+++ E IDDSS EF NFAAILEQILSHR
Sbjct: 13 GLSSKKASSRNVAVERKNLITVCRFSVKTLLEKYTAEPIDDSSEEFVNFAAILEQILSHR 72
Query: 78 LK-----GQVTWFGYESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVA 132
K G V+WF + R FWDYIR+AC KV NC+ SIENMEN+S++RAKGRAWIRVA
Sbjct: 73 FKACAPAGPVSWFSSDGQRGFWDYIRLACSKVPNNCVSSIENMENISTARAKGRAWIRVA 132
Query: 133 LMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLD 192
LMEK +SEYI+TALRD +TTRRFY+ GAI+L +EA +L GML+GL+AIDFSFCLKGE LD
Sbjct: 133 LMEKRMSEYITTALRDTRTTRRFYDSGAIMLRDEATILTGMLIGLSAIDFSFCLKGEVLD 192
Query: 193 GSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKC 252
G P VIDYTPYLK+ QS D + +DEEE + SS SE ++PE+ P + DE+SW++K
Sbjct: 193 GKTPVVIDYTPYLKFTQSYDYL-TDEEERHSAESSTSEDNSPEHPYLPLVTDEDSWYSKW 251
Query: 253 KRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYII 312
+++QK+++ QKGYLEEL+RLRE+QL + ++N+ L ++E++ ++ EK +LE +I
Sbjct: 252 HKMEQKFRIVYAQKGYLEELVRLRESQLKDLEAENRRLQLQLEEAAAQNQREKRELEGVI 311
Query: 313 VELQDQLTVLKNND----LRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYE 368
+ELQ+QLT L +D + +ELT L NQWPS G L+ A ++ LYR+H
Sbjct: 312 LELQEQLTGLIPSDHAPLAQGSKELTTPLVNQWPSLGTLNGAEGASNSKLYRRH------ 365
Query: 369 KSYQSLDQLSAEVSLSQTSLDPGQSQEGDGKQD 401
S+ S + LSAE SLS S + G+G +D
Sbjct: 366 -SFMSTEPLSAEASLSSDS-----QRLGEGTRD 392
>gi|195220720 RUN and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 506
Score = 123 bits (309), Expect = 3e-28
Identities = 73/208 (35%), Positives = 113/208 (54%), Gaps = 7/208 (3%)
Query: 14 GGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILE 71
GGG G K A ER NL+ + + S+K LI+ + T+D F ++E
Sbjct: 110 GGGSSGSGKHHPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVME 169
Query: 72 QILSHRLKGQVTWFGYESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWI 129
L H LK + T+ G +SFW + + + V + S++++ + + +GRAW+
Sbjct: 170 HCLKHGLKAKKTFLGQN--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWL 227
Query: 130 RVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGE 189
R+ALM+K LSEY+ + + FYE A+++ EE ++AG+L+GLN ID +FC+KGE
Sbjct: 228 RLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGE 287
Query: 190 GLDGSFPAVIDYTPYLKYIQSSDSISSD 217
LD S VID++ YLK SS D
Sbjct: 288 DLD-SQVGVIDFSMYLKDGNSSKGTEGD 314
>gi|109240556 RUN and FYVE domain-containing 2 isoform a [Homo
sapiens]
Length = 641
Score = 119 bits (297), Expect = 7e-27
Identities = 110/392 (28%), Positives = 187/392 (47%), Gaps = 64/392 (16%)
Query: 2 ASRSLGGLSGIRGGGGGG-GKKSLSARN-AAVERRNLITVCRFSVKTLIDR--SCFETID 57
AS+ L + GG G ++SL+ ++ AVER NL+ + + S+K LI+ S T+D
Sbjct: 13 ASQVLAWVPDAEGGRRGMLTRRSLATKDPTAVERANLLNMAKLSIKGLIESALSFGRTLD 72
Query: 58 DSSPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACRKV--SQNCICSIENM 115
P F ++E L H LK + ++ Y ++ W + + + ++ S+ ++
Sbjct: 73 SDYPPLQQFFVVMEHCLKHGLKVRKSFLSYN--KTIWGPLELVEKLYPEAEEIGASVRDL 130
Query: 116 ENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLL 175
+ + + RAW+R+ALM+K +++Y+ + FYE A+++ EE ++ G+L+
Sbjct: 131 PGLKTPLGRARAWLRLALMQKKMADYLRCLIIQRDLLSEFYEYHALMMEEEGAVIVGLLV 190
Query: 176 GLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPE 235
GLN ID + C+KGE LD S VID++ YLK E
Sbjct: 191 GLNVIDANLCVKGEDLD-SQVGVIDFSMYLK--------------------------NEE 223
Query: 236 NVGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIE 295
++G NK + V + L+QK Y+EEL R QL+ +VS + +E
Sbjct: 224 DIG-----------NKERNV--QIAAILDQKNYVEELNR----QLNSTVSSLHSRVDSLE 266
Query: 296 DSDLAHKLEKEQLEYIIVELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALD 355
S+ E + I++LQ++ N+ LRS +L T Q L+V V ++
Sbjct: 267 KSNTKLIEELAIAKNNIIKLQEE-----NHQLRSENKLILMKTQQ-----HLEVTKVDVE 316
Query: 356 TLLYR-KHNKQWYEKSY-QSLDQLSAEVSLSQ 385
T L KH++Q ++ Y ++ QL E L Q
Sbjct: 317 TELQTYKHSRQGLDEMYNEARRQLRDESQLRQ 348
>gi|7662352 RUN and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 469
Score = 118 bits (295), Expect = 1e-26
Identities = 68/192 (35%), Positives = 108/192 (56%), Gaps = 7/192 (3%)
Query: 30 AVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
A ER NL+ + + S+K LI+ + T+D F ++E L H LK + T+ G
Sbjct: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
Query: 88 ESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTA 145
+SFW + + + V + S++++ + + +GRAW+R+ALM+K LSEY+
Sbjct: 126 N--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKAL 183
Query: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
+ + FYE A+++ EE ++AG+L+GLN ID +FC+KGE LD S VID++ YL
Sbjct: 184 INKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLD-SQVGVIDFSMYL 242
Query: 206 KYIQSSDSISSD 217
K SS D
Sbjct: 243 KDGNSSKGTEGD 254
>gi|82697315 RUN and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 620
Score = 118 bits (295), Expect = 1e-26
Identities = 68/192 (35%), Positives = 108/192 (56%), Gaps = 7/192 (3%)
Query: 30 AVERRNLITVCRFSVKTLIDRSCF--ETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
A ER NL+ + + S+K LI+ + T+D F ++E L H LK + T+ G
Sbjct: 66 ANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQ 125
Query: 88 ESPRSFWDYIRVACRKVSQ--NCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTA 145
+SFW + + + V + S++++ + + +GRAW+R+ALM+K LSEY+
Sbjct: 126 N--KSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKAL 183
Query: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
+ + FYE A+++ EE ++AG+L+GLN ID +FC+KGE LD S VID++ YL
Sbjct: 184 INKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLD-SQVGVIDFSMYL 242
Query: 206 KYIQSSDSISSD 217
K SS D
Sbjct: 243 KDGNSSKGTEGD 254
Score = 30.0 bits (66), Expect = 4.5
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 8/97 (8%)
Query: 257 QKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDS----DLAHKLEKEQLEYII 312
Q L ++QK L L + NQ++ ++ Q + L++ E S +L ++L K+ I
Sbjct: 413 QSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQRLRQAERSRQSAELDNRLFKQDFGDKI 472
Query: 313 VELQ---DQLTVLKNN-DLRSRQELTAHLTNQWPSPG 345
LQ ++LT +N +L +QE L N PG
Sbjct: 473 NSLQLEVEELTRQRNQLELELKQEKERRLQNDRSIPG 509
>gi|94721336 RUN and FYVE domain-containing 1 isoform a [Homo
sapiens]
Length = 708
Score = 113 bits (283), Expect = 3e-25
Identities = 103/387 (26%), Positives = 174/387 (44%), Gaps = 74/387 (19%)
Query: 2 ASRSLGGLSGIRGGGGGGGKKSLSARNAAVERRNLITVCRFSVKTLIDR--SCFETIDDS 59
A R+ GL G G G G ++ S ER NL+ + + S+K L+ S ++D
Sbjct: 84 ALRAAAGLGG--GDSGDGTARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDAD 141
Query: 60 SPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFW---DYIRVACRKVSQNCICSIENME 116
F ++E L H LK + ++ G +SF+ + + C + S + S+ N+
Sbjct: 142 HAPLQQFFVVMEHCLKHGLKVKKSFIGQN--KSFFGPLELVEKLCPEAS-DIATSVRNLP 198
Query: 117 NVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIVLGEEANMLAGMLLG 176
+ ++ +GRAW+ +ALM+K L++Y+ + + FYE A+++ EE ++ G+L+G
Sbjct: 199 ELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVG 258
Query: 177 LNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPEN 236
LN +D + CLKGE LD S VID++ YLK +Q D G E +
Sbjct: 259 LNVLDANLCLKGEDLD-SQVGVIDFSLYLKDVQDLD--------------GGKEHERITD 303
Query: 237 VGPPFLMDENSWFNKCKRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIED 296
V L+QK Y+EEL R LS +V + + +E
Sbjct: 304 V-------------------------LDQKNYVEELNR----HLSCTVGDLQTKIDGLEK 334
Query: 297 SDLAHKLEKEQLEYIIVELQDQLTVLK--NNDLRSRQELTAHLTNQWPSPGALDVNAVAL 354
++ + E I LQ++ L+ N +R R E + +T Q
Sbjct: 335 TNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQ-------------- 380
Query: 355 DTLLYRKHNKQWYEKSYQSLDQLSAEV 381
DT K + Y+++ Q LD++ ++V
Sbjct: 381 DT----KVELETYKQTRQGLDEMYSDV 403
>gi|94721330 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 105 bits (262), Expect = 9e-23
Identities = 94/357 (26%), Positives = 162/357 (45%), Gaps = 72/357 (20%)
Query: 32 ERRNLITVCRFSVKTLIDR--SCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGYES 89
ER NL+ + + S+K L+ S ++D F ++E L H LK + ++ G
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQN- 62
Query: 90 PRSFW---DYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTAL 146
+SF+ + + C + S + S+ N+ + ++ +GRAW+ +ALM+K L++Y+ +
Sbjct: 63 -KSFFGPLELVEKLCPEAS-DIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 147 RDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLK 206
+ FYE A+++ EE ++ G+L+GLN +D + CLKGE LD S VID++ YLK
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLD-SQVGVIDFSLYLK 179
Query: 207 YIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQK 266
+Q D G E +V L+QK
Sbjct: 180 DVQDLD--------------GGKEHERITDV-------------------------LDQK 200
Query: 267 GYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLK--N 324
Y+EEL R LS +V + + +E ++ + E I LQ++ L+ N
Sbjct: 201 NYVEELNR----HLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQN 256
Query: 325 NDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEV 381
+R R E + +T Q DT K + Y+++ Q LD++ ++V
Sbjct: 257 ELIRERSEKSVEITKQ--------------DT----KVELETYKQTRQGLDEMYSDV 295
>gi|94721332 RUN and FYVE domain-containing 1 isoform b [Homo
sapiens]
Length = 600
Score = 105 bits (262), Expect = 9e-23
Identities = 94/357 (26%), Positives = 162/357 (45%), Gaps = 72/357 (20%)
Query: 32 ERRNLITVCRFSVKTLIDR--SCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGYES 89
ER NL+ + + S+K L+ S ++D F ++E L H LK + ++ G
Sbjct: 4 ERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQN- 62
Query: 90 PRSFW---DYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTAL 146
+SF+ + + C + S + S+ N+ + ++ +GRAW+ +ALM+K L++Y+ +
Sbjct: 63 -KSFFGPLELVEKLCPEAS-DIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLI 120
Query: 147 RDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLK 206
+ FYE A+++ EE ++ G+L+GLN +D + CLKGE LD S VID++ YLK
Sbjct: 121 DNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLD-SQVGVIDFSLYLK 179
Query: 207 YIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQK 266
+Q D G E +V L+QK
Sbjct: 180 DVQDLD--------------GGKEHERITDV-------------------------LDQK 200
Query: 267 GYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLK--N 324
Y+EEL R LS +V + + +E ++ + E I LQ++ L+ N
Sbjct: 201 NYVEELNR----HLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQN 256
Query: 325 NDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEV 381
+R R E + +T Q DT K + Y+++ Q LD++ ++V
Sbjct: 257 ELIRERSEKSVEITKQ--------------DT----KVELETYKQTRQGLDEMYSDV 295
>gi|109240552 RUN and FYVE domain-containing 2 isoform b [Homo
sapiens]
Length = 403
Score = 89.4 bits (220), Expect = 6e-18
Identities = 99/362 (27%), Positives = 153/362 (42%), Gaps = 96/362 (26%)
Query: 30 AVERRNLITVCRFSVKTLIDR--SCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGY 87
AVER NL+ + + S+K LI+ S T+D P F ++E L H LK + ++ Y
Sbjct: 8 AVERANLLNMAKLSIKGLIESALSFGRTLDSDYPPLQQFFVVMEHCLKHGLKVRKSFLSY 67
Query: 88 ESPRSFWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHL--SEYISTA 145
W + L+EK +E I +
Sbjct: 68 NKT------------------------------------IWGPLELVEKLYPEAEEIGAS 91
Query: 146 LRDFKTTRRFYEDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL 205
+RD FYE A+++ EE ++ G+L+GLN ID + C+KGE LD S VID++ YL
Sbjct: 92 VRDLPGLNEFYEYHALMMEEEGAVIVGLLVGLNVIDANLCVKGEDLD-SQVGVIDFSMYL 150
Query: 206 KYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLEQ 265
K E++G NK + V + L+Q
Sbjct: 151 K--------------------------NEEDIG-----------NKERNV--QIAAILDQ 171
Query: 266 KGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLKNN 325
K Y+EEL R QL+ +VS + +E S+ E + I++LQ++ N+
Sbjct: 172 KNYVEELNR----QLNSTVSSLHSRVDSLEKSNTKLIEELAIAKNNIIKLQEE-----NH 222
Query: 326 DLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYR-KHNKQWYEKSY-QSLDQLSAEVSL 383
LRS +L T Q L+V V ++T L KH++Q ++ Y ++ QL E L
Sbjct: 223 QLRSENKLILMKTQQ-----HLEVTKVDVETELQTYKHSRQGLDEMYNEARRQLRDESQL 277
Query: 384 SQ 385
Q
Sbjct: 278 RQ 279
>gi|116292170 RUN domain containing 2A [Homo sapiens]
Length = 375
Score = 62.4 bits (150), Expect = 8e-10
Identities = 69/233 (29%), Positives = 99/233 (42%), Gaps = 34/233 (14%)
Query: 54 ETIDDSSPEFNNFAAILEQILSHRLKG------------QVTWFGY--ESPRSFWDYIRV 99
E DS A E +L H LK Q F E+ FW Y++
Sbjct: 33 EIASDSDSRVTCLCAQFEAVLQHGLKRSRGLALTAAAIKQAAGFASKTETEPVFWYYVKE 92
Query: 100 ACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDG 159
K S+ + ++S +GRAW+R AL E L Y+ L D FYED
Sbjct: 93 VLNKHELQRFYSLRH---IASDVGRGRAWLRCALNEHSLERYLHMLLADRCRLSTFYEDW 149
Query: 160 AIVLGEE-ANMLAGMLLGLNAIDFSFCLKGEGLDGS---FPAVID--------YTPYLKY 207
+ V+ EE ++ML M GLN+I F+ + + L+G P V D T LK
Sbjct: 150 SFVMDEERSSMLPTMAAGLNSILFAINIDNKDLNGQSKFAPTVSDLLKESTQNVTSLLK- 208
Query: 208 IQSSDSISSDEEELRTLGSSGSESSTPENVGPPF-LMDEN-SWFNKCKRVKQK 258
+S+ +SS E+ T S+ S PE P ++ N S KCK+ ++K
Sbjct: 209 -ESTQGVSSLFREI-TASSAVSILIKPEQETDPLPVVSRNVSADAKCKKERKK 259
>gi|221139728 pleckstrin homology domain containing, family M (with
RUN domain) member 2 [Homo sapiens]
Length = 1019
Score = 46.6 bits (109), Expect = 5e-05
Identities = 45/196 (22%), Positives = 82/196 (41%), Gaps = 8/196 (4%)
Query: 43 SVKTLIDRSCFETIDDSSPEFNNFAAILEQILSHRLKGQVTWFGYESPRSFWDYIRVACR 102
SVK L +S F +D P N +L+++ H L + + + +W + R
Sbjct: 17 SVKKL--QSYFAACEDEIPAIRNHDKVLQRLCEH-LDHALLYGLQDLSSGYWVLVVHFTR 73
Query: 103 KVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIV 162
+ I IE +++V+++ + RAW+ +AL E L Y+ + ++Y A+V
Sbjct: 74 R---EAIKQIEVLQHVATNLGRSRAWLYLALNENSLESYLRLFQENLGLLHKYYVKNALV 130
Query: 163 LG-EEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYLKYIQSSDSISSDEEEL 221
+ + ++ GL I F L LD + P + DY + D + S
Sbjct: 131 CSHDHLTLFLTLVSGLEFIRFELDLDAPYLDLA-PYMPDYYKPQYLLDFEDRLPSSVHGS 189
Query: 222 RTLGSSGSESSTPENV 237
+L + S T N+
Sbjct: 190 DSLSLNSFNSVTSTNL 205
>gi|122891862 DENN/MADD domain containing 5B [Homo sapiens]
Length = 1274
Score = 46.6 bits (109), Expect = 5e-05
Identities = 26/75 (34%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Query: 112 IENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIV-LGEEANML 170
I+NM + + + RAWIR++L +K LS+++ L + T++ Y+ A + EE
Sbjct: 853 IQNMSEIKTDVGRARAWIRLSLEKKLLSQHLKQLLSNQPLTKKLYKRYAFLRCEEEREQF 912
Query: 171 AGMLLGLNAIDFSFC 185
LL LNA+D+ FC
Sbjct: 913 LYHLLSLNAVDY-FC 926
>gi|44889475 RAB6 interacting protein 1 [Homo sapiens]
Length = 1287
Score = 44.7 bits (104), Expect = 2e-04
Identities = 23/75 (30%), Positives = 42/75 (56%), Gaps = 2/75 (2%)
Query: 112 IENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTTRRFYEDGAIV-LGEEANML 170
I+N+ + + K RAW+R+++ +K LS ++ L D + T++ Y+ A + +E
Sbjct: 871 IQNIGEIKTDVGKARAWVRLSMEKKLLSRHLKQLLSDHELTKKLYKRYAFLRCDDEKEQF 930
Query: 171 AGMLLGLNAIDFSFC 185
LL NA+D+ FC
Sbjct: 931 LYHLLSFNAVDY-FC 944
>gi|40538728 pleckstrin homology domain containing, family M (with
RUN domain) member 1 [Homo sapiens]
Length = 1056
Score = 41.6 bits (96), Expect = 0.002
Identities = 24/96 (25%), Positives = 46/96 (47%), Gaps = 4/96 (4%)
Query: 93 FWDYIRVACRKVSQNCICSIENMENVSSSRAKGRAWIRVALMEKHLSEYISTALRDFKTT 152
FW ++ K + I +E++ V++ + RAW+R+AL + + Y+ L++
Sbjct: 89 FWPLLKAVTHK---HIISELEHLTFVNTDVGRCRAWLRLALNDGLMECYLKLLLQEQARL 145
Query: 153 RRFYEDGAIVL-GEEANMLAGMLLGLNAIDFSFCLK 187
+Y+ A++ EE L L GL ++ F K
Sbjct: 146 HEYYQPTALLRDAEEGEFLLSFLQGLTSLSFELSYK 181
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 37.7 bits (86), Expect = 0.022
Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 22/190 (11%)
Query: 266 KGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLK-N 324
K LE+ +++E +N+ L + IE L +KL KEQ + +E+++ LK +
Sbjct: 678 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 737
Query: 325 NDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLS 384
D++ + D+N LD K EK D LS +VS
Sbjct: 738 EDMKKSHDAIID-----------DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 786
Query: 385 QTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCG-------SLTSVASYKSLTSLKS 437
+T P + E + N++ E K+ L CG +LTS +L + S
Sbjct: 787 ETVFVPPEKHEKEIIALKSNIV-ELKKQLSELKKKCGEDQEKIHALTS--ENTNLKKMMS 843
Query: 438 NDYLASPTTE 447
N Y+ T E
Sbjct: 844 NQYVPVKTHE 853
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 37.7 bits (86), Expect = 0.022
Identities = 48/190 (25%), Positives = 77/190 (40%), Gaps = 22/190 (11%)
Query: 266 KGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYIIVELQDQLTVLK-N 324
K LE+ +++E +N+ L + IE L +KL KEQ + +E+++ LK +
Sbjct: 691 KSRLEQKSGELGKKITELTLKNQTLQKEIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVS 750
Query: 325 NDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQLSAEVSLS 384
D++ + D+N LD K EK D LS +VS
Sbjct: 751 EDMKKSHDAIID-----------DLNRKLLDVTQKYTEKKLEMEKLLLENDSLSKDVSRL 799
Query: 385 QTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCG-------SLTSVASYKSLTSLKS 437
+T P + E + N++ E K+ L CG +LTS +L + S
Sbjct: 800 ETVFVPPEKHEKEIIALKSNIV-ELKKQLSELKKKCGEDQEKIHALTS--ENTNLKKMMS 856
Query: 438 NDYLASPTTE 447
N Y+ T E
Sbjct: 857 NQYVPVKTHE 866
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 37.0 bits (84), Expect = 0.037
Identities = 44/199 (22%), Positives = 88/199 (44%), Gaps = 22/199 (11%)
Query: 253 KRVKQKYQLTLEQKGYLEELLRLRENQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYII 312
KR+++ L +QK L + + +N++ E++ + + +Q +E+ LA +KE LE I
Sbjct: 710 KRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEER-LAR--QKEVLESSI 766
Query: 313 VELQDQLTVLKNNDLRSRQELTAHLTNQWPSPGALDVNAVALDTLLYRKHN-KQWYEKSY 371
+ + ++ R Q+L HLT Q ++ + Y K K+ EK
Sbjct: 767 AHEKRKAKEALESEKRKVQDLENHLTQQ---------KEISESNIAYEKRKAKEAMEKEK 817
Query: 372 QSLDQLSAEVSLSQTSLDPGQSQEGDGKQDTLNVMSEGKEDTPSLLGLCGSLTSVASYKS 431
+ + L ++ Q +E + K+ +V++ D +++ + S K+
Sbjct: 818 KKVQDLENRLT--------KQKEELELKEQKEDVLNNKLSDALAMVEETQKTKATESLKA 869
Query: 432 LT-SLKSNDYLASPTTEMT 449
+ +LK N+ LA T T
Sbjct: 870 ESLALKLNETLAELETTKT 888
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 36.6 bits (83), Expect = 0.049
Identities = 53/227 (23%), Positives = 96/227 (42%), Gaps = 38/227 (16%)
Query: 204 YLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFN-KCKRVKQKYQLT 262
Y + ++ ++ + +D + L++L ++ T L ++ + ++ + +L
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1313
Query: 263 LEQKGYLEELLRLRENQLSESVSQNKILL-QRIEDSDLAHKLEKEQLEYIIVELQDQLTV 321
+ KG LEE R +Q+ + QN+ LL Q +E DL H EQ +YI D+L
Sbjct: 1314 SQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFH---VEQRQYI-----DKLNE 1365
Query: 322 LKNNDLRSRQELTAHLTNQW----PSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQL 377
L+ R +++L + +Q+ PSP N + L K K + +SL
Sbjct: 1366 LR----RQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL--- 1418
Query: 378 SAEVSLSQTSLDPGQSQEGDG--------KQDTLNVMSEGKEDTPSL 416
+L P +S +G QD+ +V S ED +L
Sbjct: 1419 ---------TLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTL 1456
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 36.6 bits (83), Expect = 0.049
Identities = 53/227 (23%), Positives = 96/227 (42%), Gaps = 38/227 (16%)
Query: 204 YLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDENSWFN-KCKRVKQKYQLT 262
Y + ++ ++ + +D + L++L ++ T L ++ + ++ + +L
Sbjct: 1253 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELL 1312
Query: 263 LEQKGYLEELLRLRENQLSESVSQNKILL-QRIEDSDLAHKLEKEQLEYIIVELQDQLTV 321
+ KG LEE R +Q+ + QN+ LL Q +E DL H EQ +YI D+L
Sbjct: 1313 SQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFH---VEQRQYI-----DKLNE 1364
Query: 322 LKNNDLRSRQELTAHLTNQW----PSPGALDVNAVALDTLLYRKHNKQWYEKSYQSLDQL 377
L+ R +++L + +Q+ PSP N + L K K + +SL
Sbjct: 1365 LR----RQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSL--- 1417
Query: 378 SAEVSLSQTSLDPGQSQEGDG--------KQDTLNVMSEGKEDTPSL 416
+L P +S +G QD+ +V S ED +L
Sbjct: 1418 ---------TLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTL 1455
>gi|16306548 seryl-tRNA synthetase [Homo sapiens]
Length = 514
Score = 35.8 bits (81), Expect = 0.083
Identities = 26/90 (28%), Positives = 40/90 (44%), Gaps = 6/90 (6%)
Query: 157 EDGAIVLGEEANMLAGMLLGLNAIDFSFCLKGEGLDGSFPAVIDYTPYL---KYIQSSDS 213
E GA+V G L G+L+ L + L+ G G P YTP+ + +Q
Sbjct: 183 EKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPI---YTPFFMRKEVMQEVAQ 239
Query: 214 ISSDEEELRTLGSSGSESSTPENVGPPFLM 243
+S +EEL + GSE S + +L+
Sbjct: 240 LSQFDEELYKVIGKGSEKSDDNSYDEKYLI 269
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 35.4 bits (80), Expect = 0.11
Identities = 41/145 (28%), Positives = 64/145 (44%), Gaps = 37/145 (25%)
Query: 219 EELRTLGSSGSESSTPENVGPPFLMDENSWFNKCKRVKQKYQLTLE-------------- 264
E+++TL S + S+ N NS ++QK +LT+E
Sbjct: 583 EKIQTLKSRAAGSAQGNNQAC------NSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKN 636
Query: 265 QKGYLEELLRLREN------QLSESVSQNKILLQRIEDSD----------LAHKLEKEQL 308
Q+ EE R+R N Q +E V +N L QR+E+S+ K+E+EQ
Sbjct: 637 QQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKMEREQH 696
Query: 309 EYIIVELQDQLTVLKNN-DLRSRQE 332
+ I +LQDQL+ + + D R E
Sbjct: 697 QTEIRDLQDQLSEMHDELDSAKRSE 721
>gi|5032281 dystrophin Dp427c isoform [Homo sapiens]
Length = 3677
Score = 34.7 bits (78), Expect = 0.18
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 201 YTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDEN------SWFNKCKR 254
Y YLK +Q D I + +RTL ++G E + ++ E W CK+
Sbjct: 2133 YKWYLKELQ--DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQ 2190
Query: 255 VKQKYQLTLEQKGYLEELLR-LRE--NQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYI 311
+ + + EQK L E R L E L E+ + I L+ ++ L KL EQ++ +
Sbjct: 2191 LSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL--EQVKLL 2248
Query: 312 IVELQDQLTVLK 323
+ EL + +LK
Sbjct: 2249 VEELPLRQGILK 2260
>gi|5032291 dystrophin Dp260-2 isoform [Homo sapiens]
Length = 2341
Score = 34.7 bits (78), Expect = 0.18
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 201 YTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDEN------SWFNKCKR 254
Y YLK +Q D I + +RTL ++G E + ++ E W CK+
Sbjct: 797 YKWYLKELQ--DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQ 854
Query: 255 VKQKYQLTLEQKGYLEELLR-LRE--NQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYI 311
+ + + EQK L E R L E L E+ + I L+ ++ L KL EQ++ +
Sbjct: 855 LSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL--EQVKLL 912
Query: 312 IVELQDQLTVLK 323
+ EL + +LK
Sbjct: 913 VEELPLRQGILK 924
>gi|150036268 dystrophin Dp260-1 isoform [Homo sapiens]
Length = 2344
Score = 34.7 bits (78), Expect = 0.18
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 201 YTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDEN------SWFNKCKR 254
Y YLK +Q D I + +RTL ++G E + ++ E W CK+
Sbjct: 800 YKWYLKELQ--DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQ 857
Query: 255 VKQKYQLTLEQKGYLEELLR-LRE--NQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYI 311
+ + + EQK L E R L E L E+ + I L+ ++ L KL EQ++ +
Sbjct: 858 LSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL--EQVKLL 915
Query: 312 IVELQDQLTVLK 323
+ EL + +LK
Sbjct: 916 VEELPLRQGILK 927
>gi|5032315 dystrophin Dp427p2 isoform [Homo sapiens]
Length = 3562
Score = 34.7 bits (78), Expect = 0.18
Identities = 37/132 (28%), Positives = 60/132 (45%), Gaps = 13/132 (9%)
Query: 201 YTPYLKYIQSSDSISSDEEELRTLGSSGSESSTPENVGPPFLMDEN------SWFNKCKR 254
Y YLK +Q D I + +RTL ++G E + ++ E W CK+
Sbjct: 2018 YKWYLKELQ--DGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQ 2075
Query: 255 VKQKYQLTLEQKGYLEELLR-LRE--NQLSESVSQNKILLQRIEDSDLAHKLEKEQLEYI 311
+ + + EQK L E R L E L E+ + I L+ ++ L KL EQ++ +
Sbjct: 2076 LSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKL--EQVKLL 2133
Query: 312 IVELQDQLTVLK 323
+ EL + +LK
Sbjct: 2134 VEELPLRQGILK 2145
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,908,368
Number of Sequences: 37866
Number of extensions: 730995
Number of successful extensions: 4329
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 31
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 4179
Number of HSP's gapped (non-prelim): 223
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.