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Search of human proteins with 197209974
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|197209974 coiled-coil and C2 domain containing 2A isoform a
[Homo sapiens]
(1620 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|197209974 coiled-coil and C2 domain containing 2A isoform a [... 3259 0.0
gi|197209817 coiled-coil and C2 domain containing 2A isoform b [... 2993 0.0
gi|229577352 coiled-coil and C2 domain containing 2B isoform 1 [... 376 e-104
gi|109452583 coiled-coil and C2 domain containing 2B isoform 2 [... 219 2e-56
gi|21314728 centrosomal protein 76kDa [Homo sapiens] 66 2e-10
gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens] 50 2e-05
gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens] 50 2e-05
gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens] 50 2e-05
gi|148746195 trichohyalin [Homo sapiens] 49 5e-05
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 48 9e-05
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 47 2e-04
gi|92859701 myosin VI [Homo sapiens] 46 3e-04
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 46 3e-04
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 46 3e-04
gi|110349719 titin isoform N2-A [Homo sapiens] 45 7e-04
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 44 0.001
gi|62198235 drebrin-like isoform b [Homo sapiens] 44 0.001
gi|21361670 drebrin-like isoform a [Homo sapiens] 44 0.001
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 44 0.002
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 44 0.002
gi|217272804 hyaluronan-mediated motility receptor isoform d [Ho... 43 0.002
gi|217272802 hyaluronan-mediated motility receptor isoform a [Ho... 43 0.002
gi|217416398 hyaluronan-mediated motility receptor isoform c [Ho... 43 0.002
gi|217416394 hyaluronan-mediated motility receptor isoform b [Ho... 43 0.002
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 43 0.003
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 43 0.003
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 43 0.003
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 43 0.003
gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens] 42 0.004
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 42 0.005
>gi|197209974 coiled-coil and C2 domain containing 2A isoform a [Homo
sapiens]
Length = 1620
Score = 3259 bits (8450), Expect = 0.0
Identities = 1620/1620 (100%), Positives = 1620/1620 (100%)
Query: 1 MNPREEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNP 60
MNPREEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNP
Sbjct: 1 MNPREEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNP 60
Query: 61 QEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALL 120
QEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALL
Sbjct: 61 QEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALL 120
Query: 121 QEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQ 180
QEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQ
Sbjct: 121 QEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQ 180
Query: 181 VPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMD 240
VPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMD
Sbjct: 181 VPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMD 240
Query: 241 EEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKL 300
EEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKL
Sbjct: 241 EEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKL 300
Query: 301 PENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPF 360
PENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPF
Sbjct: 301 PENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPF 360
Query: 361 PSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPC 420
PSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPC
Sbjct: 361 PSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPC 420
Query: 421 FSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKT 480
FSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKT
Sbjct: 421 FSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKT 480
Query: 481 INEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKAD 540
INEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKAD
Sbjct: 481 INEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKAD 540
Query: 541 QKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAE 600
QKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAE
Sbjct: 541 QKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAE 600
Query: 601 EHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSV 660
EHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSV
Sbjct: 601 EHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSV 660
Query: 661 TPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNW 720
TPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNW
Sbjct: 661 TPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHFGQIFNLQIVNW 720
Query: 721 PESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSG 780
PESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSG
Sbjct: 721 PESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQHVTLDHEGVGSG 780
Query: 781 VPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSI 840
VPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSI
Sbjct: 781 VPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRSALKKADAISSI 840
Query: 841 GTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFV 900
GTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFV
Sbjct: 841 GTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFRLEQLQQEFNFV 900
Query: 901 SDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEH 960
SDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEH
Sbjct: 901 SDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRLRDRNVIETKEH 960
Query: 961 IDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRP 1020
IDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRP
Sbjct: 961 IDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGLSLFKLAEQKRP 1020
Query: 1021 LRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAAS 1080
LRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAAS
Sbjct: 1021 LRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRSSRMFSEKHAAS 1080
Query: 1081 PSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYS 1140
PSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYS
Sbjct: 1081 PSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELELPFRAPNGDYS 1140
Query: 1141 TASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARID 1200
TASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARID
Sbjct: 1141 TASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMPFSTIYFQARID 1200
Query: 1201 GTFKIDIPPVLLGYSKERNMILERGFDSVRSLSEGSYITLFITIEPQLVPGESIREKFES 1260
GTFKIDIPPVLLGYSKERNMILERGFDSVRSLSEGSYITLFITIEPQLVPGESIREKFES
Sbjct: 1201 GTFKIDIPPVLLGYSKERNMILERGFDSVRSLSEGSYITLFITIEPQLVPGESIREKFES 1260
Query: 1261 QEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNN 1320
QEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNN
Sbjct: 1261 QEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNPPQELLNVYPNN 1320
Query: 1321 LQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLG 1380
LQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLG
Sbjct: 1321 LQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHAVLLCNYFLSLG 1380
Query: 1381 KKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIW 1440
KKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIW
Sbjct: 1381 KKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKNVGCLIGPDNIW 1440
Query: 1441 FNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRI 1500
FNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRI
Sbjct: 1441 FNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSDKAAAAELQDRI 1500
Query: 1501 EKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFS 1560
EKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFS
Sbjct: 1501 EKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAELLKQLGDYRFS 1560
Query: 1561 GFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR 1620
GFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR
Sbjct: 1561 GFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRNR 1620
>gi|197209817 coiled-coil and C2 domain containing 2A isoform b [Homo
sapiens]
Length = 1512
Score = 2993 bits (7759), Expect = 0.0
Identities = 1502/1571 (95%), Positives = 1506/1571 (95%), Gaps = 59/1571 (3%)
Query: 50 MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ 109
MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ
Sbjct: 1 MVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQ 60
Query: 110 AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH 169
AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH
Sbjct: 61 AARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFH 120
Query: 170 DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE 229
DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE
Sbjct: 121 DSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEE 180
Query: 230 PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP 289
PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP
Sbjct: 181 PPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIP 240
Query: 290 SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR 349
SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR
Sbjct: 241 SRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGR 300
Query: 350 ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID 409
ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID
Sbjct: 301 ILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDID 360
Query: 410 ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK 469
ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK
Sbjct: 361 ISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEK 420
Query: 470 PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP 529
PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP
Sbjct: 421 PHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTP 480
Query: 530 LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR 589
LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR
Sbjct: 481 LKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQR 540
Query: 590 AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT 649
AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT
Sbjct: 541 AKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPT 600
Query: 650 LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF 709
LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF
Sbjct: 601 LVPELSLAGSVTPNDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRPLGADFRVHF 660
Query: 710 GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH 769
GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH
Sbjct: 661 GQIFNLQIVNWPESLTLQVYETVGHSSPTLLAEVFLPIPETTVVTGRAPTEEVEFSSNQH 720
Query: 770 VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS 829
VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS
Sbjct: 721 VTLDHEGVGSGVPFSFEADGSNQLTLMTSGKVSHSVAWAIGENGIPLIPPLSQQNIGFRS 780
Query: 830 ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR 889
ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR
Sbjct: 781 ALKKADAISSIGTSGLTDMKKLAKWAAESKLDPNDPNNAPLMQLISVATSGESYVPDFFR 840
Query: 890 LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL 949
LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL
Sbjct: 841 LEQLQQEFNFVSDQELNRSKRFRLLHLRSQEVPEFRNYKQVPVYDREIMEKVFQDYEKRL 900
Query: 950 RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL 1009
RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL
Sbjct: 901 RDRNVIETKEHIDTHRAIVAKYLQQVRESVINRFLIAKQYFLLADMIVEEEVPNISILGL 960
Query: 1010 SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS 1069
SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS
Sbjct: 961 SLFKLAEQKRPLRPRRKGRKKVTAQNLSDGDIKLLVNIVRAYDIPVRKPAVSKFQQPSRS 1020
Query: 1070 SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE 1129
SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE
Sbjct: 1021 SRMFSEKHAASPSTYSPTHNADYPLGQVLVRPFVEVSFQRTVCHTTTAEGPNPSWNEELE 1080
Query: 1130 LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP 1189
LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP
Sbjct: 1081 LPFRAPNGDYSTASLQSVKDVVFINIFDEVLHDVLEDDRERGSGIHTRIERHWLGCVKMP 1140
Query: 1190 FSTIYFQARIDGTFKIDIPPVLLGYSKERNMILERGFDSVRSLSEGSYITLFITIEPQLV 1249
FSTIYFQAR + S+E +L+
Sbjct: 1141 FSTIYFQARFE--------------SQEDEKLLQ-------------------------- 1160
Query: 1250 PGESIREKFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP 1309
EKF QAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP
Sbjct: 1161 ----ATEKF---------------QAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP 1201
Query: 1310 PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA 1369
PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA
Sbjct: 1202 PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA 1261
Query: 1370 VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN 1429
VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN
Sbjct: 1262 VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN 1321
Query: 1430 VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD 1489
VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD
Sbjct: 1322 VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD 1381
Query: 1490 KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE 1549
KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE
Sbjct: 1382 KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE 1441
Query: 1550 LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV 1609
LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV
Sbjct: 1442 LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV 1501
Query: 1610 WIYVASLIRNR 1620
WIYVASLIRNR
Sbjct: 1502 WIYVASLIRNR 1512
>gi|229577352 coiled-coil and C2 domain containing 2B isoform 1 [Homo
sapiens]
Length = 401
Score = 376 bits (966), Expect = e-104
Identities = 172/371 (46%), Positives = 250/371 (67%)
Query: 1250 PGESIREKFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP 1309
P ++ ++ E + ++LQ + F+ C FPNR+ +TTV + G +TRY+K LNP
Sbjct: 31 PFSALLQQSEFLDQTEVLQRAQIFKKNCKAMFPNRRIVTTVFNDEGIQFLVTRYIKALNP 90
Query: 1310 PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA 1369
PQ+LL+++ +N AT +L+AR+VSLIPF+P+T D+W TS+ + L G++EEHA
Sbjct: 91 PQQLLDIFLHNSNATFDLIARFVSLIPFVPNTPDENDGSDIWMTSEHCISLAIGNKEEHA 150
Query: 1370 VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN 1429
+LLCN+FL GKKA +L+G ++ EG AYV+T E YL+WNP +G Y QFD FCPLK+
Sbjct: 151 ILLCNFFLYFGKKALVLLGTSVLEGHVAYVVTQETNEYLLWNPSTGQCYKQFDPFCPLKS 210
Query: 1430 VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQPEELIYQRSD 1489
V CL N+WFNIQ+ +P+ + FD ++ WK +++ + S+QPEE+IY +D
Sbjct: 211 VDCLFDDRNVWFNIQQNNTPMAVFFDYSKESFWKQLLPKNVQGTKIQSIQPEEIIYFETD 270
Query: 1490 KAAAAELQDRIEKILKEKIMDWRPRHLTRWNRYCTSTLRHFLPLLEKSQGEDVEDDHRAE 1549
K+ +L++RIE+ LK K+M+WRP+H T WNR CT LR LP LE G V + E
Sbjct: 271 KSMVEDLRNRIERTLKSKVMEWRPKHPTHWNRQCTFILRQILPKLEFGIGSFVSSEGDNE 330
Query: 1550 LLKQLGDYRFSGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSV 1609
+ L Y +GFP+ MPY +V+ +IDAVY TG+H+ + P EFALAVYIHPYP N+LSV
Sbjct: 331 FERILQFYWVTGFPIQMPYIDVQSIIDAVYQTGIHSAEFPQTEFALAVYIHPYPNNILSV 390
Query: 1610 WIYVASLIRNR 1620
W+Y+ASL++++
Sbjct: 391 WVYLASLVQHQ 401
>gi|109452583 coiled-coil and C2 domain containing 2B isoform 2 [Homo
sapiens]
Length = 322
Score = 219 bits (557), Expect = 2e-56
Identities = 99/230 (43%), Positives = 150/230 (65%)
Query: 1250 PGESIREKFESQEDEKLLQATEKFQAECALKFPNRQCLTTVIDISGKTVFITRYLKPLNP 1309
P ++ ++ E + ++LQ + F+ C FPNR+ +TTV + G +TRY+K LNP
Sbjct: 31 PFSALLQQSEFLDQTEVLQRAQIFKKNCKAMFPNRRIVTTVFNDEGIQFLVTRYIKALNP 90
Query: 1310 PQELLNVYPNNLQATAELVARYVSLIPFLPDTVSFGGICDLWSTSDQFLDLLAGDEEEHA 1369
PQ+LL+++ +N AT +L+AR+VSLIPF+P+T D+W TS+ + L G++EEHA
Sbjct: 91 PQQLLDIFLHNSNATFDLIARFVSLIPFVPNTPDENDGSDIWMTSEHCISLAIGNKEEHA 150
Query: 1370 VLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLTWEQGRYLIWNPCSGHFYGQFDTFCPLKN 1429
+LLCN+FL GKKA +L+G ++ EG AYV+T E YL+WNP +G Y QFD FCPLK+
Sbjct: 151 ILLCNFFLYFGKKALVLLGTSVLEGHVAYVVTQETNEYLLWNPSTGQCYKQFDPFCPLKS 210
Query: 1430 VGCLIGPDNIWFNIQRYESPLRINFDVTRPKLWKSFFSRSLPYPGLSSVQ 1479
V CL N+WFNIQ+ +P+ + FD ++ WK +++ + S+Q
Sbjct: 211 VDCLFDDRNVWFNIQQNNTPMAVFFDYSKESFWKQLLPKNVQGTKIQSIQ 260
Score = 93.2 bits (230), Expect = 2e-18
Identities = 37/61 (60%), Positives = 52/61 (85%)
Query: 1560 SGFPLHMPYSEVKPLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRN 1619
+GFP+ MPY +V+ +IDAVY TG+H+ + P EFALAVYIHPYP N+LSVW+Y+ASL+++
Sbjct: 262 TGFPIQMPYIDVQSIIDAVYQTGIHSAEFPQTEFALAVYIHPYPNNILSVWVYLASLVQH 321
Query: 1620 R 1620
+
Sbjct: 322 Q 322
>gi|21314728 centrosomal protein 76kDa [Homo sapiens]
Length = 659
Score = 66.2 bits (160), Expect = 2e-10
Identities = 89/416 (21%), Positives = 164/416 (39%), Gaps = 44/416 (10%)
Query: 1237 YITLFITIEPQLVPGESIREKFESQEDEKL--LQATEKFQAECALKFPNRQCLTTVI--D 1292
Y L T+ ++V + E+ ++ E E+L + A + ++ ++ + L + D
Sbjct: 253 YPPLNQTLSQEVVNTQLALERQKTAEKERLFLVYAKQWWREYLQIRPSHNSRLVKIFAQD 312
Query: 1293 ISGKTVFITRYLKPLNPPQELLNVYPNNLQATAELVARYVSLIPF-LPDTVSFGGICDLW 1351
+G + Y+KPL L T AR+V+++ + + GG + W
Sbjct: 313 ENGINRPVCSYVKPLRA---------GRLLDTPRQAARFVNVLGYERAPVIGGGGKQEQW 363
Query: 1352 STSDQFLDLLAGDEEEHAVLLCNYFLSLGKKAWLLMGNAIPEGPTAYVLT-WEQGRYLIW 1410
T FL GD E+HA LLC+ L G +A++ +G P A+V+T G W
Sbjct: 364 CTLLAFLCRNKGDCEDHANLLCSLLLGYGLEAFVCVGTKAKGVPHAWVMTCGTDGAITFW 423
Query: 1411 NPCSGHFY-------------GQFDTFCPLKNVGCLIGPDNIWFNIQRYESPLRINFDVT 1457
+GH Y Q P + +GC+ N Q ++ FD+
Sbjct: 424 ESLTGHRYIHKPTNPDEPPVAEQPKPLYPYRTIGCVFNHQMFLGNCQPSDAVETCVFDLN 483
Query: 1458 RPKLWKSFFS---RSLPYPGLSSVQP--EELIYQRSDKAAAA-ELQDRIEKILKEKIMDW 1511
WK +S+ PG ++ P L D + + E++ ++ ++ E D
Sbjct: 484 DESKWKPMSEEAIKSVCAPGATTSLPPFPPLCASTIDASVTSNEIEMQLRLLVSEHRKDL 543
Query: 1512 RPRHLTRWNRYCTSTLRHFLPLLEKSQGEDV---EDDHRAELLKQLGD-YRFSGFPLHMP 1567
T W + L L E + + ++ + + + + D + F GFP+H
Sbjct: 544 --GLTTVWEDQLSYLLSPALASYEFERTTSISAGNEEFQDAIRRAVPDGHTFKGFPIHFV 601
Query: 1568 YSEVK----PLIDAVYSTGVHNIDVPNVEFALAVYIHPYPKNVLSVWIYVASLIRN 1619
Y + + + + + V A+ V + YP++ +VWI A R+
Sbjct: 602 YRNARRAFATCLRSPFCEEIICCRGDQVRLAVRVRVFTYPESACAVWIMFACKYRS 657
>gi|110347418 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 50.1 bits (118), Expect = 2e-05
Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 46/260 (17%)
Query: 382 KKAVKYVHSSQHVIRSGDPPGNFQLD-------IDISGLIFTHHPCFS-----REHVLAA 429
+KA+++V + V + D D + + G +F H S + +
Sbjct: 617 QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILT 676
Query: 430 KLAQLYD-QYLARHQRNKAKFLTDKLQALRNA--------------------VQTGLDPE 468
K +L D Q R + N+ + L ++L L+N +QT L
Sbjct: 677 KFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQS 736
Query: 469 KPH---QSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 525
H + LD ++KTI E + ++ T++ + +EK L + K ++ RE +
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM----KNAEAERE-REL 791
Query: 526 TNTPLKLVLRKEKAD---QKADEEAYEAE-IQAEISELLEEHTEEYAQKMEEYRTSLQQW 581
+ KL K KAD +K E+ E E I E+ EL EHT Y Q++E +++ +
Sbjct: 792 KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHT-SYKQQLEAVNEAIKSY 850
Query: 582 KAWRKVQRAKKKKRKQAAEE 601
++ +V A+ K K++ +
Sbjct: 851 ESQIEVMAAEVAKNKESVNK 870
>gi|110347425 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 50.1 bits (118), Expect = 2e-05
Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 46/260 (17%)
Query: 382 KKAVKYVHSSQHVIRSGDPPGNFQLD-------IDISGLIFTHHPCFS-----REHVLAA 429
+KA+++V + V + D D + + G +F H S + +
Sbjct: 617 QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILT 676
Query: 430 KLAQLYD-QYLARHQRNKAKFLTDKLQALRNA--------------------VQTGLDPE 468
K +L D Q R + N+ + L ++L L+N +QT L
Sbjct: 677 KFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQS 736
Query: 469 KPH---QSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 525
H + LD ++KTI E + ++ T++ + +EK L + K ++ RE +
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM----KNAEAERE-REL 791
Query: 526 TNTPLKLVLRKEKAD---QKADEEAYEAE-IQAEISELLEEHTEEYAQKMEEYRTSLQQW 581
+ KL K KAD +K E+ E E I E+ EL EHT Y Q++E +++ +
Sbjct: 792 KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHT-SYKQQLEAVNEAIKSY 850
Query: 582 KAWRKVQRAKKKKRKQAAEE 601
++ +V A+ K K++ +
Sbjct: 851 ESQIEVMAAEVAKNKESVNK 870
>gi|110347420 structural maintenance of chromosomes 2 [Homo sapiens]
Length = 1197
Score = 50.1 bits (118), Expect = 2e-05
Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 46/260 (17%)
Query: 382 KKAVKYVHSSQHVIRSGDPPGNFQLD-------IDISGLIFTHHPCFS-----REHVLAA 429
+KA+++V + V + D D + + G +F H S + +
Sbjct: 617 QKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILT 676
Query: 430 KLAQLYD-QYLARHQRNKAKFLTDKLQALRNA--------------------VQTGLDPE 468
K +L D Q R + N+ + L ++L L+N +QT L
Sbjct: 677 KFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQS 736
Query: 469 KPH---QSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 525
H + LD ++KTI E + ++ T++ + +EK L + K ++ RE +
Sbjct: 737 SYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKM----KNAEAERE-REL 791
Query: 526 TNTPLKLVLRKEKAD---QKADEEAYEAE-IQAEISELLEEHTEEYAQKMEEYRTSLQQW 581
+ KL K KAD +K E+ E E I E+ EL EHT Y Q++E +++ +
Sbjct: 792 KDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHT-SYKQQLEAVNEAIKSY 850
Query: 582 KAWRKVQRAKKKKRKQAAEE 601
++ +V A+ K K++ +
Sbjct: 851 ESQIEVMAAEVAKNKESVNK 870
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 48.5 bits (114), Expect = 5e-05
Identities = 50/209 (23%), Positives = 88/209 (42%), Gaps = 13/209 (6%)
Query: 490 QTRKFRDAEQEKDRTLLKTIIKVWKEMKSLRE------FQRFTNTPLK---LVLRKEKAD 540
+T +F D EQ + R LL+ K +E + R FQ + VLRKE+
Sbjct: 200 ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 541 QKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAE 600
+ +E + E+Q E +L + +E ++ +E Q+ + ++++R ++++R++ E
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 601 EHPGD----EIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSL 656
E E E E+ L + + EQE R Q RR E +L
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 657 AGSVTPNDQCPRAEVSRREDVKKRSVYLK 685
+ Q R + RRE +R L+
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLR 408
Score = 44.7 bits (104), Expect = 7e-04
Identities = 50/220 (22%), Positives = 105/220 (47%), Gaps = 10/220 (4%)
Query: 436 DQYLARHQRNKAKFLTDKLQA-LRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKF 494
+Q R QR K + ++LQ LR+ Q + E+ + L ++ + E R+ R
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE-KRLEQERREQRLK 568
Query: 495 RDAEQEKDRTLLKTIIKVWKEMKSLRE---FQRFTNTPLKLVLRKEKADQKADEEAYEAE 551
R+ E+ +D+ L + + + +K +E QR ++ + ++E+ +Q+ E E E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 552 IQAEI--SELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 609
+ ++ SE EE ++ ++ ++ R Q+ K + +R +++ +++ EE E+AE
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERRE-QRLKREEEEERLEQRLKREHEEERREQELAE 687
Query: 610 PYPEE--DLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWE 647
E+ + +K P+ + E + R+ SR R E
Sbjct: 688 EEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQE 727
Score = 40.0 bits (92), Expect = 0.018
Identities = 136/700 (19%), Positives = 258/700 (36%), Gaps = 81/700 (11%)
Query: 13 EEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTR- 71
E+ ++ +E+ + ++ + +++R+ +++ + +E + L QE E+ R
Sbjct: 547 EQLLKREEEKRLEQERREQRLKREQEERRDQL-LKREEERRQQRLKREQEERLEQRLKRE 605
Query: 72 ---LLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRP 128
L RR R P R S R + Q R + E R
Sbjct: 606 EVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER---------RE 656
Query: 129 RRLRSPSKKE-LETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPS 187
+RL+ ++E LE E E ER +QE+ + + + +R K + Q+ S
Sbjct: 657 QRLKREEEEERLEQRLKRE--HEEERREQELAEEEQEQARERIKSRIPKWQWQLE----S 710
Query: 188 AEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNG 247
+A ++ + EG + + + + E + +EEE + +E +
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Query: 248 DDAEDFLLGLDHVADDFVAVRPADYESIHDRLQME----REMLFIPSRQTVPTYKKLPEN 303
AE+ ++ RP E +L+ E RE F+P + ++
Sbjct: 771 WQAEE----KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRE 826
Query: 304 VQP--RFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFP 361
+ +FLE+E R E A+ Q E L +D ERR + R
Sbjct: 827 REKELQFLEEEEQLQ--RRERAQQLQE--EEDGLQEDQERRRSQEQRR------------ 870
Query: 362 SRPPVLTQEQSIKAELETLYKKAV--KYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHP 419
+ E+ K TLY K + + Q +++ + Q +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE--ELQREEREKRRRQEQER 928
Query: 420 CFSREHVLAAKLAQLY--DQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTI 477
+ E L + QL ++ R Q + ++ DK + G +PEK +
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQ--ER 986
Query: 478 QKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVW-KEMKSLREFQRFTNTPLKLVLRK 536
+K E + ++ + E+EK R + W ++ + E Q+ L+ K
Sbjct: 987 EKKYREEEELQQEEEQLLREEREKRRR------QEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 537 EKADQKADEEAYEAEIQAEISELL-EEHTEEYAQKME-EYRTSLQQWKAWRKVQRAKKKK 594
+ ++ + E E+Q E +LL EE Q++E +YR + + ++ R + +K
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEK 1100
Query: 595 RKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQE--------------VRERAAQ 640
R++ E E E EE+ + E R +E++ +RE +
Sbjct: 1101 RRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEK 1160
Query: 641 SRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKR 680
RR+ E E L +Q R E +R ++R
Sbjct: 1161 RRRQELERQYREEEELQ---QEEEQLLREEQEKRRQERER 1197
Score = 38.5 bits (88), Expect = 0.053
Identities = 49/215 (22%), Positives = 85/215 (39%), Gaps = 23/215 (10%)
Query: 478 QKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKE 537
Q+ E + E R+ + R+ E+E+ L+ ++ +E + RE Q L+ +
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 538 KADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQ 597
+ Q E+ E Q + E H +++ Q+ E R +Q +R KR++
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQ------EERRDWLKREE 462
Query: 598 AAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAV-IEQEVR----ERAAQSRRRPWEPTLVP 652
E H + ++ L + E +R + +E+E R ER Q RR E
Sbjct: 463 ETERHEQER-----RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQ 517
Query: 653 ELS-------LAGSVTPNDQCPRAEVSRREDVKKR 680
L L + Q R + RRE + KR
Sbjct: 518 RLKRQEEEERLQQRLRSEQQLRREQEERREQLLKR 552
Score = 38.5 bits (88), Expect = 0.053
Identities = 45/232 (19%), Positives = 98/232 (42%), Gaps = 23/232 (9%)
Query: 436 DQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQT---R 492
++ R Q + KF+ D+ Q R Q L E+ + + Q + ++ + R
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR 1643
Query: 493 KFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEI 552
KF + E + R + ++ ++ K RE ++ + LR+++ D+K EE +
Sbjct: 1644 KFLEEEPQLRRQEREQQLRHDRDRK-FREEEQLLQEGEEQQLRRQERDRKFREEEQQLRR 1702
Query: 553 QAEISELLEEHT------------EEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAE 600
Q + L+E EE + E + L++ + +RK+ ++ + ++ +
Sbjct: 1703 QERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQ 1762
Query: 601 EHPGDEIAEPYPEEDLVKPSPPE------PTDRAVIEQE-VRERAAQSRRRP 645
+ E + EE+ ++ E +DR E+E +R+ + + RP
Sbjct: 1763 QLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Score = 35.4 bits (80), Expect = 0.45
Identities = 128/651 (19%), Positives = 244/651 (37%), Gaps = 111/651 (17%)
Query: 4 REEKVKIITEEFIENDEDADMGRQNKNSKVR----RQPRKKQPPTAVPKEMVSEKSHLGN 59
R+E+ K EE E+ + R+ + + R RQ RKK ++++ E+
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 60 PQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESAL 119
QE ++ + L + + L T R E + R E+LQ + E L
Sbjct: 1043 LQERERQYREEEELQ---QEEEQLLGEERETRRR--QELERQYRKEEELQ----QEEEQL 1093
Query: 120 LQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKP 179
L+E P R R+ R +E E E+++ ++++ + + + + R+ + +
Sbjct: 1094 LREEPEKRRRQERERQCREEE---------ELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 180 QVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEG---EEEEPPAQGGG 236
+V EE +PE +E + Q+EEE EE+E Q
Sbjct: 1145 EVQ----QEEEQL----LREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196
Query: 237 KEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPT 296
++ EEE L + D +D P ++ D
Sbjct: 1197 RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDN----------------KV 1240
Query: 297 YKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNP 356
Y K EN Q R LED L + + + R Q+ RRW D
Sbjct: 1241 YCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQE-RRRWQQRD--------- 1290
Query: 357 IKPFPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFT 416
+ FP +E+ ++ E + K+ + + ++R + + D
Sbjct: 1291 -RHFP-------EEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRK----- 1337
Query: 417 HHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDT 476
F E L L + +Q L R +R++ KF ++L+ + L+ E+ + +
Sbjct: 1338 ----FREEEQL---LQEREEQPLRRQERDR-KFREEELRHQEQG-RKFLEEEQRLRRQER 1388
Query: 477 IQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRK 536
+K + E + ++R + + Q++DR K E Q+ L +
Sbjct: 1389 ERKFLKE-EQQLRCQEREQQLRQDRDR-------------KFREEEQQ---------LSR 1425
Query: 537 EKADQKADEEAYEAEIQAEISELLEEH---TEEYAQKMEEYRTSLQQWKAWRKVQRAKKK 593
++ D+K EE + Q + LEE +E +K E LQ+ + + ++ + +
Sbjct: 1426 QERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Query: 594 KRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 644
K + ++ E + E++L P +R +E+E + Q +R+
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEP----ERKFLEEEQQLHRQQRQRK 1532
Score = 32.0 bits (71), Expect = 5.0
Identities = 26/108 (24%), Positives = 49/108 (45%), Gaps = 7/108 (6%)
Query: 535 RKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKK 594
R+ + Q+ + E E E Q+E E LE+ + ++ EE Q+W+ +R +++
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQERLEQRDRQ--RRDEELWRQRQEWQ-----EREERRA 188
Query: 595 RKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSR 642
++ + G E E EE L + E + E++ + R Q R
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDR 236
Score = 31.2 bits (69), Expect = 8.5
Identities = 64/334 (19%), Positives = 116/334 (34%), Gaps = 35/334 (10%)
Query: 13 EEFIENDEDADMGRQNKNSKVRR--QPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKT 70
E+ + E RQ+++ K R Q R+++ + ++ K L + QE+ +
Sbjct: 1537 EQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERK 1596
Query: 71 RLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRR 130
+ R + F E + RE+ Q R + + L+E P R +
Sbjct: 1597 FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQE 1656
Query: 131 LRSPSKKELETEFGTEP-----GKEVERTQQEVDS-------------------QSYSRV 166
+ + + +F E G+E + +QE D Q ++
Sbjct: 1657 REQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQL 1716
Query: 167 KFHDSARKIKPKPQVPPGFPSAE----EAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEE 222
+ + RK + + Q+ + E Y PE E++ + + R +EE
Sbjct: 1717 RRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE 1776
Query: 223 EEGEEEEPPAQGGGKEMD----EEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDR 278
E+ +E Q +E D EEE L + E L E R
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQR 1836
Query: 279 LQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDE 312
L+ ER+ + Q T +K Q + E+E
Sbjct: 1837 LRQERDRQYRAEEQ-FATQEKSRREEQELWQEEE 1869
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 47.8 bits (112), Expect = 9e-05
Identities = 56/230 (24%), Positives = 98/230 (42%), Gaps = 34/230 (14%)
Query: 438 YLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIR----QTRK 493
+L Q NK + + Q L Q E Q L QK I + K + R Q R+
Sbjct: 356 FLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRR 415
Query: 494 FRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQ 553
R+A ++++R + + +E + L E +R ++E+ ++A+EE E +
Sbjct: 416 EREARRQQEREQRR---REQEEKRRLEELERRR--------KEEEERRRAEEEKRRVERE 464
Query: 554 AE-ISELLEE---HTEEYAQKMEEYRTSLQQ--WKAWRKVQRAKKKKRKQAAEE------ 601
E I LEE H E Q++ + + L + W+ + ++A++ +R+ E+
Sbjct: 465 QEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSL 524
Query: 602 -------HPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 644
HP P P+++ KPS P +A E R R + R R
Sbjct: 525 QHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFR 574
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 46.6 bits (109), Expect = 2e-04
Identities = 49/214 (22%), Positives = 85/214 (39%), Gaps = 6/214 (2%)
Query: 490 QTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYE 549
+ R D EK ++ +K +K ++ KS + P K + +KE+ EE
Sbjct: 773 EARSPADKFPEKAKSPVKEEVKSPEKAKS--PLKEDAKAPEKEIPKKEEVKSPVKEEEKP 830
Query: 550 AEIQA-EISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIA 608
E++ E + EE K EE + S ++ ++ + K +++K+ A E P +
Sbjct: 831 QEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKV 890
Query: 609 EPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRR---RPWEPTLVPELSLAGSVTPNDQ 665
E EE K P P A + EV+E A + EP + +
Sbjct: 891 EAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950
Query: 666 CPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSR 699
P + ++ E KK K KE +T+S+
Sbjct: 951 APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSK 984
Score = 42.7 bits (99), Expect = 0.003
Identities = 40/175 (22%), Positives = 74/175 (42%), Gaps = 14/175 (8%)
Query: 3 PREEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQE 62
P+E KVK ++ E A + K + + KK+ PK V EK +E
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE----APKPKVEEK------KE 879
Query: 63 PVQEEPK-TRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQ 121
P E+PK +++ + + P P E + +EK + A+ + + A +
Sbjct: 880 PAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAK 939
Query: 122 EIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEV--DSQSYSRVKFHDSARK 174
E P ++ +P KK+ + E +P +E +T+ + D ++ S+ A K
Sbjct: 940 EPSKPAEKKEAAPEKKDTKEEKAKKP-EEKPKTEAKAKEDDKTLSKEPSKPKAEK 993
Score = 40.4 bits (93), Expect = 0.014
Identities = 49/245 (20%), Positives = 104/245 (42%), Gaps = 32/245 (13%)
Query: 6 EKVKIITEEFIENDEDADMG-RQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPV 64
EK K +E +++ E A +++ + + P+K++ + V +E ++ + P +
Sbjct: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA 842
Query: 65 QEE-----PKTRLLSMTVRR-GPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESA 118
+EE PKT + + P+ P P E ++ K++A + +AE
Sbjct: 843 EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEK--KEPAVEKPKESKVEAKKEEAEDK 900
Query: 119 LLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPK 178
+++PTP +P+K E++ + +P ++ E ++E D K + ++ + K
Sbjct: 901 --KKVPTPEKE---APAKVEVKED--AKPKEKTEVAKKEPDD-----AKAKEPSKPAEKK 948
Query: 179 PQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKE 238
P + EE + + EEKPK +A + + E +P A+ K
Sbjct: 949 EAAPEKKDTKEE-----------KAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKS 997
Query: 239 MDEEE 243
++
Sbjct: 998 SSTDQ 1002
Score = 38.9 bits (89), Expect = 0.041
Identities = 56/245 (22%), Positives = 108/245 (44%), Gaps = 39/245 (15%)
Query: 3 PREEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQE 62
P +E+ + ++F E + + + + K+ + + P K+ P++ + +K + +
Sbjct: 769 PAKEEARSPADKFPEKAK-SPVKEEVKSPEKAKSPLKED--AKAPEKEIPKKEEV---KS 822
Query: 63 PVQEEPKTRLLSMTVRRGPRSLPP--IPSTSRTGFAEFSMRGRMREKLQAARSKAESALL 120
PV+EE K + + V+ P+ P+T +T EK SK E A
Sbjct: 823 PVKEEEKPQ--EVKVKEPPKKAEEEKAPATPKT-----------EEKKD---SKKEEAPK 866
Query: 121 QEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEV---DSQSYSRVKFHDSARKIKP 177
+E P P+ + P+ E E E KE +++V + ++ ++V+ + A K K
Sbjct: 867 KEAPKPKVEEKKEPAV-EKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDA-KPKE 924
Query: 178 KPQVPPGFPSAEEAYNFFTFNFDPEP-EGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGG 236
K +V P +A EP + +E+K A + T +E+ + EE+P +
Sbjct: 925 KTEVAKKEPDDAKA---------KEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975
Query: 237 KEMDE 241
KE D+
Sbjct: 976 KEDDK 980
Score = 32.0 bits (71), Expect = 5.0
Identities = 32/144 (22%), Positives = 60/144 (41%), Gaps = 14/144 (9%)
Query: 536 KEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKR 595
K K +K+++E E Q E +++ EE TEE EE ++ K + + +
Sbjct: 443 KIKVVEKSEKETVIVEEQTEETQVTEEVTEE-----EEKEAKEEEGKEEEGGEEEEAEGG 497
Query: 596 KQAAEEHPGDEIAEPYPE-EDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPEL 654
++ + P +E A P E + VK P + E+E + A+ + PE
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKS--------PEK 549
Query: 655 SLAGSVTPNDQCPRAEVSRREDVK 678
+ + + P A+ +E+ K
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAK 573
Score = 32.0 bits (71), Expect = 5.0
Identities = 50/253 (19%), Positives = 102/253 (40%), Gaps = 25/253 (9%)
Query: 6 EKVKIITEEFIENDEDADMGRQN--KNSKVRRQPRKKQP--PTAVPKEMVSEKSHLGNPQ 61
EK K T+E ++ E A + K+ + + P K + P + +E +
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695
Query: 62 EPVQEEPKTRLLSMTVRRGPRSLP-----PIPSTSRTGFAEFSMRGRMREKLQAARSKAE 116
PV+EE K+ + + + P P+ ++T S + + A+S E
Sbjct: 696 SPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP-E 754
Query: 117 SALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIK 176
A ++ +P + +P+K+E + P K ++EV S ++ + A+
Sbjct: 755 KAKTLDVKSPEAK---TPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKA-- 809
Query: 177 PKPQVPPGFPSAEEAYNFFTFNFDP------EPEGSEEKPKARHRAGTNQEEEEGEEEEP 230
P+ ++P EE + P EP E+ KA T ++++ +EE P
Sbjct: 810 PEKEIP----KKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAP 865
Query: 231 PAQGGGKEMDEEE 243
+ +++E++
Sbjct: 866 KKEAPKPKVEEKK 878
>gi|92859701 myosin VI [Homo sapiens]
Length = 1285
Score = 46.2 bits (108), Expect = 3e-04
Identities = 48/257 (18%), Positives = 108/257 (42%), Gaps = 22/257 (8%)
Query: 444 RNKAKFLTDKLQALRNAVQTGLDPEKPHQSLD------TIQKTINEYKSEI--------R 489
+NK K+ + ++ ++ L + +D T++K ++++ +
Sbjct: 807 KNKIKYRAEACIKMQKTIRMWLCKRRHKPRIDGLVKVGTLKKRLDKFNEVVSVLKDGKPE 866
Query: 490 QTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYE 549
++ ++ E D + K + + + +E+ + +L+ +K Q+ +E
Sbjct: 867 MNKQIKNLEISIDTLMAKIKSTMMTQEQIQKEYDALVKSSEELLSALQKKKQQEEEAERL 926
Query: 550 AEIQAEISELLE--EHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEI 607
IQ E+ + + E E+ +K EE R + +A RK + ++KKR+ ++
Sbjct: 927 RRIQEEMEKERKRREEDEKRRRKEEEERRMKLEMEAKRKQEEEERKKRED------DEKR 980
Query: 608 AEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCP 667
+ E L + E +AV+EQE R+R R E L+ + + A +
Sbjct: 981 IQAEVEAQLARQKEEESQQQAVLEQERRDRELALRIAQSEAELISDEAQADLALRRNDGT 1040
Query: 668 RAEVSRREDVKKRSVYL 684
R +++ + K+ S +L
Sbjct: 1041 RPKMTPEQMAKEMSEFL 1057
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 45.8 bits (107), Expect = 3e-04
Identities = 52/249 (20%), Positives = 100/249 (40%), Gaps = 17/249 (6%)
Query: 7 KVKIITEEFIENDEDADMG------RQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNP 60
K +++ + +E E A + S V + P +++ + VPK V EK P
Sbjct: 598 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 657
Query: 61 QEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALL 120
+ PV+E+ K+ + V +S P+P + + G+ +K + + E+
Sbjct: 658 KSPVEEKGKSPVSKSPVEEKAKS--PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKE 715
Query: 121 QEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQ 180
+++ + P KK+ E+ E EV + V K + + + +
Sbjct: 716 EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKE 775
Query: 181 VPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMD 240
G +EE D +GS ++ A + +EE E E +E +G G+E +
Sbjct: 776 KAGGEGGSEEE------GSDKGAKGSRKEDIAVNGEVEGKEEVEQETKE---KGSGREEE 826
Query: 241 EEELLNGDD 249
+ + NG D
Sbjct: 827 KGVVTNGLD 835
Score = 40.8 bits (94), Expect = 0.011
Identities = 50/247 (20%), Positives = 98/247 (39%), Gaps = 26/247 (10%)
Query: 17 ENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVS-------EKSHLGNPQEPVQEEPK 69
E + +A+ + +K ++ +K A +E+V+ EK+ P+ PV+E+ K
Sbjct: 568 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK 627
Query: 70 TRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPR 129
+ + V +S P G + + + EK ++ SK+ + P P+
Sbjct: 628 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVP-KSPVEEKGKSPVSKSPVEEKAKSPVPKSP 686
Query: 130 RLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAE 189
+ SK E+ GK ++ ++E VK K++ K + P P +
Sbjct: 687 VEEAKSKAEV--------GKGEQKEEEE------KEVKEAPKEEKVEKKEEKPKDVPEKK 732
Query: 190 EAYNFFTFNFDPEPEGSEEKPKARHRAGTNQE----EEEGEEEEPPAQGGGKEMDEEELL 245
+A + E + K T +E ++E E+E+ +GG +E ++
Sbjct: 733 KAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGA 792
Query: 246 NGDDAED 252
G ED
Sbjct: 793 KGSRKED 799
Score = 36.2 bits (82), Expect = 0.26
Identities = 44/202 (21%), Positives = 71/202 (35%), Gaps = 34/202 (16%)
Query: 41 QPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSM 100
+PP + ++ +K + P+ VQ + ++ T +S T+ T SM
Sbjct: 427 RPPITISSKI--QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSM 484
Query: 101 RGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDS 160
+ +E + + E+ + P + +P KE E E E G+E E + E
Sbjct: 485 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAK 544
Query: 161 QSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQ 220
AEE + E EGS EK + G +
Sbjct: 545 SD------------------------QAEEGGS--------EKEGSSEKEEGEQEEGETE 572
Query: 221 EEEEGEEEEPPAQGGGKEMDEE 242
E EGEE E + +E EE
Sbjct: 573 AEAEGEEAEAKEEKKVEEKSEE 594
Score = 33.5 bits (75), Expect = 1.7
Identities = 45/182 (24%), Positives = 81/182 (44%), Gaps = 23/182 (12%)
Query: 468 EKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLRE------ 521
E+ + L + Q TI + ++E+R T+ + + LL + + E+ + R+
Sbjct: 350 ERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLNVKMALDIEIAAYRKLLEGEE 409
Query: 522 --FQRFTNT---PL---KLVLRKEKADQKADEEAYEAEIQAE-ISELLEE-HTEEYAQKM 571
F F + PL + + QK EA + ++Q + + E++EE E+ +M
Sbjct: 410 TRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEM 469
Query: 572 EEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIE 631
EE T++ + A + +KK+ + EE P E EE K SP + T V E
Sbjct: 470 EEALTAITEELAVS--MKEEKKEAAEEKEEEP-----EAEEEEVAAKKSPVKATAPEVKE 522
Query: 632 QE 633
+E
Sbjct: 523 EE 524
Score = 32.3 bits (72), Expect = 3.8
Identities = 38/169 (22%), Positives = 68/169 (40%), Gaps = 13/169 (7%)
Query: 536 KEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKR 595
+E+ + +A+ E EAE + E + +EE +EE A K E + + K ++AK
Sbjct: 566 QEEGETEAEAEGEEAEAKEE--KKVEEKSEEVATKEELVADAKVE-----KPEKAKSPVP 618
Query: 596 KQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELS 655
K EE + + EE P P P + + + + P + V E
Sbjct: 619 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-- 676
Query: 656 LAGSVTP----NDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRP 700
A S P + +AEV + E ++ +K ++V + +P
Sbjct: 677 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 725
Score = 31.6 bits (70), Expect = 6.5
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 6/57 (10%)
Query: 200 DPEPEGSEEKPKARHR----AGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAED 252
+ EPE EE+ A+ +EEEGE+EE +G +E +E+E D AE+
Sbjct: 496 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEGAKSDQAEE 550
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 45.8 bits (107), Expect = 3e-04
Identities = 52/249 (20%), Positives = 100/249 (40%), Gaps = 17/249 (6%)
Query: 7 KVKIITEEFIENDEDADMG------RQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNP 60
K +++ + +E E A + S V + P +++ + VPK V EK P
Sbjct: 222 KEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP 281
Query: 61 QEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALL 120
+ PV+E+ K+ + V +S P+P + + G+ +K + + E+
Sbjct: 282 KSPVEEKGKSPVSKSPVEEKAKS--PVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKE 339
Query: 121 QEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQ 180
+++ + P KK+ E+ E EV + V K + + + +
Sbjct: 340 EKVEKKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKE 399
Query: 181 VPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMD 240
G +EE D +GS ++ A + +EE E E +E +G G+E +
Sbjct: 400 KAGGEGGSEEE------GSDKGAKGSRKEDIAVNGEVEGKEEVEQETKE---KGSGREEE 450
Query: 241 EEELLNGDD 249
+ + NG D
Sbjct: 451 KGVVTNGLD 459
Score = 40.8 bits (94), Expect = 0.011
Identities = 50/247 (20%), Positives = 98/247 (39%), Gaps = 26/247 (10%)
Query: 17 ENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVS-------EKSHLGNPQEPVQEEPK 69
E + +A+ + +K ++ +K A +E+V+ EK+ P+ PV+E+ K
Sbjct: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK 251
Query: 70 TRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPR 129
+ + V +S P G + + + EK ++ SK+ + P P+
Sbjct: 252 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVP-KSPVEEKGKSPVSKSPVEEKAKSPVPKSP 310
Query: 130 RLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAE 189
+ SK E+ GK ++ ++E VK K++ K + P P +
Sbjct: 311 VEEAKSKAEV--------GKGEQKEEEE------KEVKEAPKEEKVEKKEEKPKDVPEKK 356
Query: 190 EAYNFFTFNFDPEPEGSEEKPKARHRAGTNQE----EEEGEEEEPPAQGGGKEMDEEELL 245
+A + E + K T +E ++E E+E+ +GG +E ++
Sbjct: 357 KAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGA 416
Query: 246 NGDDAED 252
G ED
Sbjct: 417 KGSRKED 423
Score = 36.2 bits (82), Expect = 0.26
Identities = 44/202 (21%), Positives = 71/202 (35%), Gaps = 34/202 (16%)
Query: 41 QPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSM 100
+PP + ++ +K + P+ VQ + ++ T +S T+ T SM
Sbjct: 51 RPPITISSKI--QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSM 108
Query: 101 RGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDS 160
+ +E + + E+ + P + +P KE E E E G+E E + E
Sbjct: 109 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAK 168
Query: 161 QSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQ 220
AEE + E EGS EK + G +
Sbjct: 169 SD------------------------QAEEGGS--------EKEGSSEKEEGEQEEGETE 196
Query: 221 EEEEGEEEEPPAQGGGKEMDEE 242
E EGEE E + +E EE
Sbjct: 197 AEAEGEEAEAKEEKKVEEKSEE 218
Score = 32.3 bits (72), Expect = 3.8
Identities = 38/169 (22%), Positives = 68/169 (40%), Gaps = 13/169 (7%)
Query: 536 KEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKR 595
+E+ + +A+ E EAE + E + +EE +EE A K E + + K ++AK
Sbjct: 190 QEEGETEAEAEGEEAEAKEE--KKVEEKSEEVATKEELVADAKVE-----KPEKAKSPVP 242
Query: 596 KQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELS 655
K EE + + EE P P P + + + + P + V E
Sbjct: 243 KSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEE-- 300
Query: 656 LAGSVTP----NDQCPRAEVSRREDVKKRSVYLKVLFNNKEVSRTVSRP 700
A S P + +AEV + E ++ +K ++V + +P
Sbjct: 301 KAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP 349
Score = 31.6 bits (70), Expect = 6.5
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 6/57 (10%)
Query: 200 DPEPEGSEEKPKARHR----AGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAED 252
+ EPE EE+ A+ +EEEGE+EE +G +E +E+E D AE+
Sbjct: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEGAKSDQAEE 174
Score = 31.2 bits (69), Expect = 8.5
Identities = 29/95 (30%), Positives = 47/95 (49%), Gaps = 9/95 (9%)
Query: 541 QKADEEAYEAEIQAE-ISELLEE-HTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQA 598
QK EA + ++Q + + E++EE E+ +MEE T++ + A + +KK+ +
Sbjct: 61 QKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVS--MKEEKKEAAEE 118
Query: 599 AEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQE 633
EE P E EE K SP + T V E+E
Sbjct: 119 KEEEP-----EAEEEEVAAKKSPVKATAPEVKEEE 148
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 44.7 bits (104), Expect = 7e-04
Identities = 128/627 (20%), Positives = 229/627 (36%), Gaps = 88/627 (14%)
Query: 60 PQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESAL 119
P++PV EE K + P +P +P + + +
Sbjct: 9954 PRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEKPPPAKVPEVPKKPVP 10013
Query: 120 LQEIPTPRPRRLRSPSKKELETEFGTEPGKEVE-RTQQEVDSQSYSRVKFHDSARKIKPK 178
+++P P P+++ +P K E P K+V ++V++ K + +K+ P+
Sbjct: 10014 EEKVPVPVPKKVEAPPAKVPEVPKKPVPEKKVPVPAPKKVEAPP---AKVPEVPKKLIPE 10070
Query: 179 PQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKE 238
+ P P EA P P+ +++ QEEE EEE
Sbjct: 10071 EKKPTPVPKKVEA---------PPPKVPKKREPVPVPVALPQEEEVLFEEE--------I 10113
Query: 239 MDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQT-VPTY 297
+ EEE+L + E+ L + V + V P + E + ++ E ++P + VP
Sbjct: 10114 VPEEEVL--PEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEEEYVPEEEEFVPEE 10171
Query: 298 KKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRLLMQDPERRWFGDDGRILALPNPI 357
+ LPE V+P+ V V + + E ++++ E ++ +P +
Sbjct: 10172 EVLPE-VKPK--------VPVPAPVPEIKKKVTEKKVVIPKKEE---APPAKVPEVPKKV 10219
Query: 358 KP----FPSRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGL 413
+ P VL E + + E E + ++ + S + PP ++ +
Sbjct: 10220 EEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVEEVAPPR--VPEVIKKAV 10277
Query: 414 IFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQS 473
P + AK+++ + K K +A V PE P +
Sbjct: 10278 PEAPTPVPKKVEAPPAKVSK-------KIPEEKVPVPVQKKEAPPAKV-----PEVPKK- 10324
Query: 474 LDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLV 533
+K + K E K R +EK + + V KE L V
Sbjct: 10325 --VPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVV-KERLELE------------V 10369
Query: 534 LRKEKADQKADEEAYEAEIQAEISEL--------LEEHTEEYAQKMEEYRTSLQQWKAWR 585
+ E + +EE +E E E E LE+H E ++E+ ++ ++A
Sbjct: 10370 VEAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEA-E 10428
Query: 586 KVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLV--KPSP---PEPTDRAVIEQEVRERAAQ 640
+V+ +K K E I P +V K P PE + V+E++V R +
Sbjct: 10429 EVEVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKV--RVPE 10486
Query: 641 SRRRPWEPTLVPELSLAGSVTPNDQCP 667
R P PT VPE+ V P + P
Sbjct: 10487 EPRVP--PTKVPEVLPPKEVVPEKKVP 10511
Score = 38.9 bits (89), Expect = 0.041
Identities = 49/203 (24%), Positives = 92/203 (45%), Gaps = 19/203 (9%)
Query: 463 TGLDPEKPHQSLDTIQKTINEYK----SEIRQTRKFRDAEQEKDRTLLK---TIIKVWKE 515
T L P K + +D K E K + ++ +K ++A EK + + K I+ ++E
Sbjct: 9017 TTLIPAKAPEIIDVSSKA-EEVKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEE 9075
Query: 516 MKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEE---YAQKME 572
E + +T P + +E + D E + E + E+ E EE EE Y ++ E
Sbjct: 9076 PYDELEVEPYTE-PFEQPYYEEPDE---DYEEIKVEAKKEVHEEWEEDFEEGQEYYEREE 9131
Query: 573 EYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQ 632
Y ++W+ + +R + +K+ EE ++ PE+ P PP+ + VIE
Sbjct: 9132 GYDEGEEEWEEAYQ-EREVIQVQKEVYEESHERKVPAKVPEKKA--PPPPKVIKKPVIE- 9187
Query: 633 EVRERAAQSRRRPWEPTLVPELS 655
++ + + + + T VPE+S
Sbjct: 9188 KIEKTSRRMEEEKVQVTKVPEVS 9210
Score = 38.1 bits (87), Expect = 0.070
Identities = 130/696 (18%), Positives = 241/696 (34%), Gaps = 116/696 (16%)
Query: 38 RKKQPPTAVP----KEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRT 93
R++ PP AVP K++ E+ + +E V PK L + P+P +
Sbjct: 9391 REESPPPAVPEIPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPEEKVAVPVPVAKKA 9450
Query: 94 G--FAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKELETEFGT------ 145
AE S + + EK A K A+ Q + R E E G
Sbjct: 9451 PPPRAEVSKKTVVEEKRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYR 9510
Query: 146 ----EPGKEVERTQQEVDSQSYSRV---KFHDSARKIKPKPQ-----------VPPGFPS 187
E +E E T+ EV + V K H +++++ +P + P P+
Sbjct: 9511 EEEREEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTERQEKKIVLKPKIPA 9570
Query: 188 AEEAYNFFTFNFDPEPEGSEEKPKA-------------RHRAGTNQEEEEGEEEEPPAQG 234
E +P P E PK + + + EE ++ P +
Sbjct: 9571 KIE---------EPPPAKVPEAPKKIVPEKKVPAPVPKKEKVPPPKVPEEPKKPVPEKKV 9621
Query: 235 GGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRLQMEREMLFIPSRQTV 294
K + EE L PA H ++ E ++L +++
Sbjct: 9622 PPKVIKMEEPL-----------------------PAKVTERHMQITQEEKVLVAVTKKEA 9658
Query: 295 PTYKKLPENVQPRFLEDEGLYTGVRPE------VARTNQNIM-ENRLLMQDPERRWFGDD 347
P ++PE + E++ L + E V + ++ E ++ ++ P+R
Sbjct: 9659 PPKARVPEEPKRAVPEEKVLKLKPKREEEPPAKVTEFRKRVVKEEKVSIEAPKRE----- 9713
Query: 348 GRILALPNPIKPFP----SRPPVLTQEQSIKAELETLYKKAVKYVHSSQHVIRSGDPPGN 403
P PIK +E+++ + E Y++ +Y + +
Sbjct: 9714 ------PQPIKEVTIMEEKERAYTLEEEAVSVQREEEYEEYEEYDYKEFEEYEPTEEYDQ 9767
Query: 404 FQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYL-ARHQRNKAKFLTDKLQALRNAVQ 462
++ + + H + E + + ++ + + + AK L + + V
Sbjct: 9768 YEEYEEREYERYEEHEEYITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEEKVPVP 9827
Query: 463 TGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQE---KDRTLLKTII---KVWKEM 516
+ P + K + E K I T++ ++ E K K ++ KV
Sbjct: 9828 IPKKLKPPPPKVPEEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPR 9887
Query: 517 KSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRT 576
K + R P +L + +E A+E E+ + E L E EEY + EE+ T
Sbjct: 9888 KEVAPPVRVPEVPKEL---------EPEEVAFEEEVVTHVEEYLVEEEEEYIHEEEEFIT 9938
Query: 577 SLQQWKAWR-KVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVR 635
+ KV +K + + P + E P + P PE +I ++ +
Sbjct: 9939 EEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLIPKKEK 9998
Query: 636 ERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEV 671
A+ P +P VPE + V + P A+V
Sbjct: 9999 PPPAKVPEVPKKP--VPEEKVPVPVPKKVEAPPAKV 10032
Score = 37.0 bits (84), Expect = 0.16
Identities = 52/209 (24%), Positives = 75/209 (35%), Gaps = 35/209 (16%)
Query: 32 KVRRQPRKKQ--PPTAVP---KEMVSEKS----HLGNPQEPVQEEPKTRLLSMTVRRGPR 82
KV P KK PP VP KE+V EK P+ P + P+ ++ ++ P
Sbjct: 10509 KVPVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKAAVPEKKVPE 10568
Query: 83 SLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKELETE 142
++PP P + E +K+ AA K ++P +P + E +
Sbjct: 10569 AIPPKPESPPPEVPEAPKEVVPEKKVPAAPPKKPEVTPVKVP-------EAPKEVVPEKK 10621
Query: 143 FGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPE 202
P K+ E +V V I PKP+ PP P E +PE
Sbjct: 10622 VPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPP--PEVFE---------EPE 10670
Query: 203 PEGSEEKPKARHRAGTNQEEEEGEEEEPP 231
EE P + EE E PP
Sbjct: 10671 EVALEEPPA--------EVVEEPEPAAPP 10691
Score = 37.0 bits (84), Expect = 0.16
Identities = 57/253 (22%), Positives = 98/253 (38%), Gaps = 33/253 (13%)
Query: 5 EEKVKIITEEFIE--NDEDADMGRQNKNSKV----RRQPRKKQPPTAVPKEMVSEK--SH 56
EE KII E+ + +A ++ + KV + +PR PP A PKE V EK
Sbjct: 10841 EEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQL 10900
Query: 57 LGNPQEPVQEEP----KTRLLSMTVRRGPRSLPP-IPSTSRTGFAEFSMRGRMREKLQAA 111
P++ V E+P K L + V G + + +P E ++ +R++ +
Sbjct: 10901 KAIPKKKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEE 10960
Query: 112 RSKAESALLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDS 171
K E L+++ + P+ E P K VE + ++ ++
Sbjct: 10961 EPKVEPKKLEKV--------KKPAVPE------PPPPKPVEEVEVPTVTKRERKIPEPTK 11006
Query: 172 ARKIKPKPQVPPGFPSAEEAYNFFTFNFDP-EPEGSE-----EKPKARHRAGTNQEEEEG 225
+IKP +P P + T P EPE + P +A +EE
Sbjct: 11007 VPEIKPAIPLPAPEPKPKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAPKEEA 11066
Query: 226 EEEEPPAQGGGKE 238
+ + P +G K+
Sbjct: 11067 AKPKGPIKGVPKK 11079
Score = 35.8 bits (81), Expect = 0.35
Identities = 25/80 (31%), Positives = 36/80 (45%), Gaps = 3/80 (3%)
Query: 591 KKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTL 650
K RK+ EE P EP E + KP+ PEP +E+ + R+ EPT
Sbjct: 10950 KSVLRKRPEEEEPK---VEPKKLEKVKKPAVPEPPPPKPVEEVEVPTVTKRERKIPEPTK 11006
Query: 651 VPELSLAGSVTPNDQCPRAE 670
VPE+ A + + P+ E
Sbjct: 11007 VPEIKPAIPLPAPEPKPKPE 11026
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 44.3 bits (103), Expect = 0.001
Identities = 37/174 (21%), Positives = 84/174 (48%), Gaps = 18/174 (10%)
Query: 478 QKTINEYKSEI-RQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRK 536
++ I E + ++ RQ K R+ E+++ + K+WK+ + +RE + K+ ++
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQ----EQEEKMWKQEEKIREQEE------KIQEQE 625
Query: 537 EKADQKADEEAYEAEIQAEISELLEEHTE---EYAQKMEEYRTSLQQWKAWRKVQRAKKK 593
EK ++ ++ + E+ E E + E E E +KM+E ++ W+ K++ +KK
Sbjct: 626 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM--WRQEEKIREQEKK 683
Query: 594 KRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWE 647
R+Q + +E+ + +E+ + + ++ QE E+ + + WE
Sbjct: 684 IREQEEKIREQEEMMQ--EQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 735
Score = 37.4 bits (85), Expect = 0.12
Identities = 52/247 (21%), Positives = 109/247 (44%), Gaps = 30/247 (12%)
Query: 413 LIFTHHPCFSREHVLAAKLAQLYDQYLARHQRNKA--KFLTDKLQALRNAVQTGLDPEKP 470
L ++ H E +++L+D + + +A T K +A R + L E+
Sbjct: 146 LYYSQHAVKQLEGEARDLISRLHDSWKFAGELEQALSAVATQKKKADRYIEE--LTKERD 203
Query: 471 HQSLDTIQKTINEYKSEIRQTR---KFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTN 527
SL+ + TI + + + + + K + E EK L KE+K R+ +R
Sbjct: 204 ALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV-----KELK--RKLER--- 253
Query: 528 TPLKLVLRKEKADQKADE-----EAYEAEIQAEI--SELLEEHTEEYAQKMEEYRTSLQQ 580
KL+L +++ +AD ++ A++QA++ +EL ++ +KM +Q+
Sbjct: 254 --AKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQE 311
Query: 581 WKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQ 640
W+ K+Q ++K R+Q EE ++ + +E+++ + + + E E+ +
Sbjct: 312 WE--EKIQEQEEKIREQ--EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 367
Query: 641 SRRRPWE 647
WE
Sbjct: 368 QEEMMWE 374
Score = 35.0 bits (79), Expect = 0.59
Identities = 25/151 (16%), Positives = 67/151 (44%), Gaps = 10/151 (6%)
Query: 478 QKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKE 537
+K + K RQ K + E+ ++ + ++W++ + + E + K+ ++E
Sbjct: 444 EKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEE 503
Query: 538 KADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQW----------KAWRKV 587
K ++ ++ + E E E + E E+ ++ E+ R + W K W +
Sbjct: 504 KIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE 563
Query: 588 QRAKKKKRKQAAEEHPGDEIAEPYPEEDLVK 618
+R +++ + EE ++ + + +E+ ++
Sbjct: 564 KRQEQEDKMWRQEEKIREQEEKVWRQEEKIR 594
Score = 33.5 bits (75), Expect = 1.7
Identities = 55/265 (20%), Positives = 102/265 (38%), Gaps = 30/265 (11%)
Query: 4 REEKVKIITEEFIENDEDADMGRQNKN-----SKVRRQPRK--KQPPTAVPKEMVSEKSH 56
R+E+ KI +E +++A M RQ + K+R Q +K +Q +E + E+
Sbjct: 413 RQEEEKIREQEK-RQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 471
Query: 57 LGNPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAE 116
+E ++E K R+ + + + ++RE+ + R + E
Sbjct: 472 RQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEE 531
Query: 117 SALLQEIPTPRPRRLRSPSKKELETEFGTEPGK--EVERTQQEVDSQSYSRVKFHDSARK 174
QE ++R + E E E K E E+ Q++ D K + K
Sbjct: 532 KMWRQE------EKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEK 585
Query: 175 I------------KPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEE 222
+ K + Q + E+ + E + E++ K R + QE+
Sbjct: 586 VWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQ 645
Query: 223 EE--GEEEEPPAQGGGKEMDEEELL 245
EE GE+EE + K ++EE +
Sbjct: 646 EEKMGEQEEKMCEQEEKMQEQEETM 670
Score = 33.1 bits (74), Expect = 2.2
Identities = 42/220 (19%), Positives = 102/220 (46%), Gaps = 27/220 (12%)
Query: 431 LAQLYDQYLARHQRNKAKFLTDKLQAL--RNAVQTGLDPEKPHQSLDTIQKTINEYKSEI 488
L Q Q A H + + ++ KLQA N + L+ ++ + +K I E++ +I
Sbjct: 258 LPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK-IQEWEEKI 316
Query: 489 R-QTRKFRDAEQ---EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKAD 544
+ Q K R+ E+ E++ + + +W++ + +R + +++ KE+ ++ +
Sbjct: 317 QEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQE-------EMMWEKEEKMRRQE 369
Query: 545 EEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPG 604
E +E E E EE E +K+ E + + + R+ + ++++ K +E
Sbjct: 370 EMMWEKE---EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 426
Query: 605 DEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 644
++ A+ + +E+ ++ E+++RE+ + R+
Sbjct: 427 EQEAKMWRQEEKIREQ----------EEKIREQEKKMWRQ 456
Score = 32.7 bits (73), Expect = 2.9
Identities = 31/149 (20%), Positives = 70/149 (46%), Gaps = 24/149 (16%)
Query: 468 EKPHQSLDTIQ---KTINEYKSEIRQTRKFRDAEQEK-----------DRTLLKTIIKVW 513
EK + + IQ + I E + +IR+ + ++EK + + + +W
Sbjct: 612 EKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMW 671
Query: 514 KEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEE 573
++ + +RE ++ + + +E+ Q+ +E+ +E E ++ E+ EE Q+ EE
Sbjct: 672 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE-----EKMCEQ--EEKMQEQEE 724
Query: 574 YRTSLQQWKAWRKVQRAKKKKRKQAAEEH 602
+ Q+ K W + R ++++ K +EH
Sbjct: 725 -KMRRQEEKMWEQEVRLRQQEEKM--QEH 750
>gi|62198235 drebrin-like isoform b [Homo sapiens]
Length = 430
Score = 43.9 bits (102), Expect = 0.001
Identities = 46/184 (25%), Positives = 73/184 (39%), Gaps = 30/184 (16%)
Query: 51 VSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPP--IPSTSRTGFAEFSMRGRMREKL 108
+ EK Q +++E + R L RR R S RT + + R R +
Sbjct: 192 LEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQRTWEQQQEVVSRNRNEQ 251
Query: 109 QAA-------RSKAESALLQEIPTPRPRRLRSP-SKKEL---ETEFGTEPGKEVERTQQE 157
++A + K + I +P+P +LRSP +K+L ET FG EP + R + +
Sbjct: 252 ESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRAD 311
Query: 158 VDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAG 217
+ ++ +P P PP AEE + PE E E+P + G
Sbjct: 312 LPAE--------------EPAPSTPPCLVQAEEE---AVYEEPPEQETFYEQPPLVQQQG 354
Query: 218 TNQE 221
E
Sbjct: 355 AGSE 358
>gi|21361670 drebrin-like isoform a [Homo sapiens]
Length = 431
Score = 43.9 bits (102), Expect = 0.001
Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 31/185 (16%)
Query: 51 VSEKSHLGNPQEPVQEEPKTRLLSMTVRRGPRSLPP---IPSTSRTGFAEFSMRGRMREK 107
+ EK Q +++E + R L RR R SRT + + R R +
Sbjct: 192 LEEKRRAEEAQRQLEQERRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNE 251
Query: 108 LQAA-------RSKAESALLQEIPTPRPRRLRSP-SKKEL---ETEFGTEPGKEVERTQQ 156
++A + K + I +P+P +LRSP +K+L ET FG EP + R +
Sbjct: 252 QESAVHPREIFKQKERAMSTTSISSPQPGKLRSPFLQKQLTQPETHFGREPAAAISRPRA 311
Query: 157 EVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRA 216
++ ++ +P P PP AEE + PE E E+P +
Sbjct: 312 DLPAE--------------EPAPSTPPCLVQAEEE---AVYEEPPEQETFYEQPPLVQQQ 354
Query: 217 GTNQE 221
G E
Sbjct: 355 GAGSE 359
Score = 31.2 bits (69), Expect = 8.5
Identities = 34/191 (17%), Positives = 75/191 (39%), Gaps = 15/191 (7%)
Query: 440 ARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQ 499
A H A FL + + ++PE ++ + K S +++ +F+D
Sbjct: 98 ASHVSTMASFLKGAHVTINARAEEDVEPEC---IMEKVAKASGANYSFHKESGRFQDVGP 154
Query: 500 EKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEIS-E 558
+ + V+++ ++ E +R KE+ +++ +E+ E Q ++ E
Sbjct: 155 QAP------VGSVYQKTNAVSEIKRVGKDSFWAKAEKEEENRRLEEKRRAEEAQRQLEQE 208
Query: 559 LLEEHTEEYAQKMEEYRT----SLQQWKAWRKVQRAKKKKR-KQAAEEHPGDEIAEPYPE 613
E E A++ + Y+ + Q + W + Q + R +Q + HP + +
Sbjct: 209 RRERELREAARREQRYQEQGGEASPQSRTWEQQQEVVSRNRNEQESAVHPREIFKQKERA 268
Query: 614 EDLVKPSPPEP 624
S P+P
Sbjct: 269 MSTTSISSPQP 279
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 43.5 bits (101), Expect = 0.002
Identities = 41/205 (20%), Positives = 91/205 (44%), Gaps = 25/205 (12%)
Query: 470 PHQSLDTIQKTINEYKSEIR-QTRKFRDAEQ----------EKDRTLLKTIIKVWKEMKS 518
P +T+Q+ + + E+R Q +K R E+ E++ + + K+W++ K
Sbjct: 263 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKR 322
Query: 519 LREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQA-EISELLEEHTE------------ 565
LRE ++ K LR++K ++ +E+ E E + E E + E E
Sbjct: 323 LREQEKELREQEK-ELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ 381
Query: 566 EYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPT 625
E + +E + Q+ + W + +R ++K+ + +E +++ + E+ + +
Sbjct: 382 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRD 441
Query: 626 DRAVIEQEVRERAAQSRRRPWEPTL 650
+++E R R + + R E T+
Sbjct: 442 QEEKMQEEERIREREKKMREEEETM 466
Score = 43.5 bits (101), Expect = 0.002
Identities = 33/159 (20%), Positives = 74/159 (46%), Gaps = 10/159 (6%)
Query: 490 QTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYE 549
Q +K D E+ ++ + K W + + +RE +R K +R+E+ + EE +
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKK--MREEEEMMREQEE--K 611
Query: 550 AEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 609
+ Q E + EE E +KM+E Q+ K W + ++ +++ K ++ ++ +
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQE-----QEEKMWEQEEKMWEQEEKMWEQQRLPEQKEK 666
Query: 610 PYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSR-RRPWE 647
+ E + + + + + EQE E+ Q + ++ W+
Sbjct: 667 LWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWD 705
Score = 42.0 bits (97), Expect = 0.005
Identities = 38/187 (20%), Positives = 88/187 (47%), Gaps = 12/187 (6%)
Query: 466 DPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 525
D E+ + + +++ + + E R+ + QE++ + + K+W++ + ++E +
Sbjct: 580 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEE- 638
Query: 526 TNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTE-EYAQKMEEYRTSL-QQWKA 583
K+ ++EK ++ +E+ +E + E E L EH + + +KM+E + +Q K
Sbjct: 639 -----KMWEQEEKMWEQ-EEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKM 692
Query: 584 WRKVQRAKKK---KRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQ 640
+K Q +KK + K EE + + EE++++ + ++ QE E +
Sbjct: 693 EKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWE 752
Query: 641 SRRRPWE 647
+ WE
Sbjct: 753 QEEKMWE 759
Score = 38.1 bits (87), Expect = 0.070
Identities = 35/146 (23%), Positives = 74/146 (50%), Gaps = 14/146 (9%)
Query: 483 EYKSEIR-QTRKFRDAEQ---EKDRTL------LKTIIKVWKEMKSLREFQRFTNTPLKL 532
E + ++R Q +K RD E+ E+D L ++ K+W++++ +RE ++ K
Sbjct: 380 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKT 439
Query: 533 VLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKK 592
++EK ++ E +++ E + E+ EE QK EE Q+ K W++ QR +
Sbjct: 440 RDQEEKMQEEERIREREKKMREEEETMREQ--EEKMQKQEENMWE-QEEKEWQQ-QRLPE 495
Query: 593 KKRKQAAEEHPGDEIAEPYPEEDLVK 618
+K K +E ++ + + +E+ ++
Sbjct: 496 QKEKLWEQEKMQEQEEKIWEQEEKIR 521
Score = 38.1 bits (87), Expect = 0.070
Identities = 38/178 (21%), Positives = 79/178 (44%), Gaps = 28/178 (15%)
Query: 483 EYKSEIRQTRKFRDAE--QEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKAD 540
E K + ++ + + E QE++ + + K+W++ + + E QR +
Sbjct: 616 EEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL-------------PE 662
Query: 541 QKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAW-----RKVQRAKKKKR 595
QK E+ +E E E ++ E+ + + Q+ E +T Q+ K W R+ + +++++
Sbjct: 663 QK--EKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 596 KQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPE 653
K EE E E E++ + + + EQE E+ + + WE +PE
Sbjct: 721 KMREEEEMMREQEEKMQEQE----EKMQEQEEEMWEQE--EKMWEQEEKMWEQQRLPE 772
Score = 32.7 bits (73), Expect = 2.9
Identities = 50/247 (20%), Positives = 101/247 (40%), Gaps = 28/247 (11%)
Query: 1 MNPREEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAV--PKEMVSEKSHLG 58
M +E+K++ E E DE + K ++R Q + + + K+M ++
Sbjct: 385 MREQEQKMRDQEERMWEQDERL----REKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
Query: 59 NPQEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESA 118
+ +E +QEE + R +R + MRE+ + + + E+
Sbjct: 441 DQEEKMQEEERIREREKKMREEEET--------------------MREQEEKMQKQEENM 480
Query: 119 LLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPK 178
QE + +RL +K E E E +++ ++++ Q + R+ K +
Sbjct: 481 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 540
Query: 179 PQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKE 238
Q + E+ + +D E E E+K + + + +QEE+ EEE + K
Sbjct: 541 EQEDQMWEQEEKMRDQEQKMWDQE-ERMEKKTQEQEKKTWDQEEKM-REEERMREREKKM 598
Query: 239 MDEEELL 245
+EEE++
Sbjct: 599 REEEEMM 605
Score = 32.7 bits (73), Expect = 2.9
Identities = 37/181 (20%), Positives = 79/181 (43%), Gaps = 7/181 (3%)
Query: 469 KPHQSLDTIQKTINEYKSEIR-QTRKFRDAE---QEKDRTLLKTIIKVWKEMKSLREFQR 524
+ +S+ +K + E + +R Q K ++ E QE++ + + K+W++ + + E QR
Sbjct: 710 REEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769
Query: 525 FTNTPLKLVLRKEKADQ-KADEEAYEAEIQAEISELLEEHTEEYAQKM--EEYRTSLQQW 581
KL ++ +Q K E+ + Q E EE +KM +E + Q+
Sbjct: 770 LPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEE 829
Query: 582 KAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQS 641
K W + ++ ++ K +E +E + E+ + + + EQE + R +
Sbjct: 830 KMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Query: 642 R 642
+
Sbjct: 890 K 890
Score = 31.6 bits (70), Expect = 6.5
Identities = 33/189 (17%), Positives = 83/189 (43%), Gaps = 29/189 (15%)
Query: 478 QKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLR-- 535
Q+ + E K ++ + K ++ E+ K+W++ + +R+ + K+ +
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEE-----------KIWEQEEKIRDQEEMWGQEKKMWRQEK 538
Query: 536 -KEKADQKADEEAYEAEIQAEI---SELLEEHTEE-------YAQKMEEYRTSLQQWKAW 584
+E+ DQ ++E + + ++ E +E+ T+E +KM E ++ K
Sbjct: 539 MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKM 598
Query: 585 RKVQRAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRR 644
R+ + +++ ++ E+ +E + E+ + + + + EQE E+ + +
Sbjct: 599 REEEEMMREQEEKMQEQ---EEKMQEQEEKMWEQEEKMQEQEEKMWEQE--EKMWEQEEK 653
Query: 645 PWEPTLVPE 653
WE +PE
Sbjct: 654 MWEQQRLPE 662
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 43.5 bits (101), Expect = 0.002
Identities = 86/443 (19%), Positives = 166/443 (37%), Gaps = 68/443 (15%)
Query: 202 EPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVA 261
EP+ EE+ + +++ EE ++E A+ E +E E + +
Sbjct: 237 EPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQ------------ 284
Query: 262 DDFVAVRPADYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPE 321
D +A A E+ ERE R+ + +K + R E+E R
Sbjct: 285 DKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQR 344
Query: 322 VARTNQNIMENRLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLY 381
+ + E R +++ E+R + R A +E+ K E +
Sbjct: 345 IKEEEKRAAEERQRIKEEEKRAAEERQRARA---------------EEEEKAKVEEQKRN 389
Query: 382 KKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLAR 441
K+ + H+ Q G+ +++ I G + + + + A L + ++ +
Sbjct: 390 KQLEEKKHAMQETKIKGE-----KVEQKIEGK-WVNEKKAQEDKLQTAVLKKQGEEKGTK 443
Query: 442 HQRNKAKFLTD-----KLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQ--TRKF 494
Q + K D K + ++ +P++ +S +K E KS+ + T K
Sbjct: 444 VQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 503
Query: 495 RDAEQEKDRTLLKTI-----------IKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKA 543
+ E R + ++ K ++ LR + T + EK QK
Sbjct: 504 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESE-----EFEKLKQKQ 558
Query: 544 DEEAYEAE----IQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAA 599
E A E E + E ++LEE EE +K EE L++ + R+++ +++R +AA
Sbjct: 559 QEAALELEELKKKREERRKVLEE--EEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 616
Query: 600 EEHPGDEIAEPYPEEDLVKPSPP 622
E+ + PE+ L P
Sbjct: 617 EKR------QKMPEDGLSDDKKP 633
Score = 34.7 bits (78), Expect = 0.77
Identities = 26/115 (22%), Positives = 57/115 (49%), Gaps = 1/115 (0%)
Query: 537 EKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRK 596
E+A +A+E+A E + +E E EE + EE + ++ K + ++ K++ K
Sbjct: 291 ERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEK 350
Query: 597 QAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLV 651
+AAEE + E E+ + + E ++A +E++ R + + ++ + T +
Sbjct: 351 RAAEERQRIKEEEKRAAEERQR-ARAEEEEKAKVEEQKRNKQLEEKKHAMQETKI 404
>gi|217272804 hyaluronan-mediated motility receptor isoform d [Homo
sapiens]
Length = 638
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 37/237 (15%)
Query: 422 SREHV--LAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKP-----HQSL 474
+REH L A++ L +++ Q +KLQ + + L EK HQ L
Sbjct: 221 NREHNENLNAEMQNLKQKFILEQQER------EKLQQKELQIDSLLQQEKELSSSLHQKL 274
Query: 475 DTIQKTI----NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPL 530
+ Q+ + N ++ E++QT D Q+K+ + + ++ +E KS E L
Sbjct: 275 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------EL 327
Query: 531 KLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQ-- 588
KL+ K K + E++ A QA + LL+E + Q +E+ + +KA +
Sbjct: 328 KLLEEKLKGKEAELEKSSAAHTQATL--LLQEKYDSMVQSLEDVTAQFESYKALTASEIE 385
Query: 589 ---------RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRE 636
+ K K + AE+ +A ++ V+ T A+ E E++E
Sbjct: 386 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 442
>gi|217272802 hyaluronan-mediated motility receptor isoform a [Homo
sapiens]
Length = 725
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 37/237 (15%)
Query: 422 SREHV--LAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKP-----HQSL 474
+REH L A++ L +++ Q +KLQ + + L EK HQ L
Sbjct: 308 NREHNENLNAEMQNLKQKFILEQQER------EKLQQKELQIDSLLQQEKELSSSLHQKL 361
Query: 475 DTIQKTI----NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPL 530
+ Q+ + N ++ E++QT D Q+K+ + + ++ +E KS E L
Sbjct: 362 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------EL 414
Query: 531 KLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQ-- 588
KL+ K K + E++ A QA + LL+E + Q +E+ + +KA +
Sbjct: 415 KLLEEKLKGKEAELEKSSAAHTQATL--LLQEKYDSMVQSLEDVTAQFESYKALTASEIE 472
Query: 589 ---------RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRE 636
+ K K + AE+ +A ++ V+ T A+ E E++E
Sbjct: 473 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 529
>gi|217416398 hyaluronan-mediated motility receptor isoform c [Homo
sapiens]
Length = 709
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 37/237 (15%)
Query: 422 SREHV--LAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKP-----HQSL 474
+REH L A++ L +++ Q +KLQ + + L EK HQ L
Sbjct: 292 NREHNENLNAEMQNLKQKFILEQQER------EKLQQKELQIDSLLQQEKELSSSLHQKL 345
Query: 475 DTIQKTI----NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPL 530
+ Q+ + N ++ E++QT D Q+K+ + + ++ +E KS E L
Sbjct: 346 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------EL 398
Query: 531 KLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQ-- 588
KL+ K K + E++ A QA + LL+E + Q +E+ + +KA +
Sbjct: 399 KLLEEKLKGKEAELEKSSAAHTQATL--LLQEKYDSMVQSLEDVTAQFESYKALTASEIE 456
Query: 589 ---------RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRE 636
+ K K + AE+ +A ++ V+ T A+ E E++E
Sbjct: 457 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 513
>gi|217416394 hyaluronan-mediated motility receptor isoform b [Homo
sapiens]
Length = 724
Score = 43.1 bits (100), Expect = 0.002
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 37/237 (15%)
Query: 422 SREHV--LAAKLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKP-----HQSL 474
+REH L A++ L +++ Q +KLQ + + L EK HQ L
Sbjct: 307 NREHNENLNAEMQNLKQKFILEQQER------EKLQQKELQIDSLLQQEKELSSSLHQKL 360
Query: 475 DTIQKTI----NEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPL 530
+ Q+ + N ++ E++QT D Q+K+ + + ++ +E KS E L
Sbjct: 361 CSFQEEMVKEKNLFEEELKQTLDELDKLQQKEEQAERLVKQLEEEAKSRAE-------EL 413
Query: 531 KLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQ-- 588
KL+ K K + E++ A QA + LL+E + Q +E+ + +KA +
Sbjct: 414 KLLEEKLKGKEAELEKSSAAHTQATL--LLQEKYDSMVQSLEDVTAQFESYKALTASEIE 471
Query: 589 ---------RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRE 636
+ K K + AE+ +A ++ V+ T A+ E E++E
Sbjct: 472 DLKLENSSLQEKAAKAGKNAEDVQHQILATESSNQEYVRMLLDLQTKSALKETEIKE 528
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 42.7 bits (99), Expect = 0.003
Identities = 42/216 (19%), Positives = 100/216 (46%), Gaps = 14/216 (6%)
Query: 441 RHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEI-RQTRKFRDAE- 498
+ + +AKFL ++Q N +Q + + + L +K I + + ++ RQ + R+ E
Sbjct: 214 KRKLERAKFLLPQVQT--NTLQEEM--WRQEEELREQEKKIRKQEEKMWRQEERLREQEG 269
Query: 499 --QEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEI 556
+E++ + + ++ ++ K LRE ++ KL ++E+ ++ ++ + E E
Sbjct: 270 KMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQ 329
Query: 557 SELL---EEHTEEYAQKMEEYRTSL--QQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPY 611
E + EE E ++M E + Q+ + W + +R ++K+ + +E ++ E
Sbjct: 330 EEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQ-EEKM 388
Query: 612 PEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWE 647
EE+ ++ + + +E E+ + WE
Sbjct: 389 QEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Score = 38.1 bits (87), Expect = 0.070
Identities = 73/456 (16%), Positives = 180/456 (39%), Gaps = 44/456 (9%)
Query: 207 EEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVA 266
EE+ + + + QEE+ +EE + GK ++EE + + + +
Sbjct: 240 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKR--------LREQEKE 291
Query: 267 VRPADYESIHDR-LQMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVART 325
+R + E + L+ + E + + +K+ E + + ++E L+
Sbjct: 292 LREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW--------EQ 343
Query: 326 NQNIMENRLLMQDPERRWFGDDGRILALPNPIKP----------FPSRPPVLTQEQSIKA 375
+ + E M+D E R + D R+ ++ + +E+ ++
Sbjct: 344 EKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMRE 403
Query: 376 ELETLYKKAVKYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLY 435
E ET+ ++ K +++ + Q + ++ +E + + ++
Sbjct: 404 EEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIR 463
Query: 436 DQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFR 495
DQ Q K + +K++ + + E+ + D QK ++ + Q + R
Sbjct: 464 DQEEMWGQEKKM-WRQEKMREQEDQMW-----EQEEKMRDQEQKMWDQEERMWEQDERLR 517
Query: 496 DAEQEKDRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEK--ADQKADEEAYEAEIQ 553
+ E+ ++ K+W++ + +RE ++ K ++EK +++ E + +
Sbjct: 518 EKEER-----MREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Query: 554 AEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAEPYPE 613
E+ EE +E +KM E + W+ K+Q ++K +Q + +E + +
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKM--WEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630
Query: 614 EDLV--KPSPPEPTDRAVIEQEVRERAAQSRRRPWE 647
E+++ + + + + EQE + R + + R E
Sbjct: 631 EEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE 666
Score = 36.2 bits (82), Expect = 0.26
Identities = 23/141 (16%), Positives = 69/141 (48%), Gaps = 4/141 (2%)
Query: 466 DPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRF 525
D E+ + + +++ + + E R+ + QE++ + + K+W++ + ++E +
Sbjct: 551 DQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK 610
Query: 526 TNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWR 585
+ + +E+ D+ ++E E+ E E ++E E+ ++ E+ R ++ +
Sbjct: 611 MWEQEEKMWEQEEEDKMQEQE----EMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQE 666
Query: 586 KVQRAKKKKRKQAAEEHPGDE 606
+ + +++K ++ E+ G E
Sbjct: 667 EKMQGQEEKMREQEEKMQGQE 687
Score = 33.1 bits (74), Expect = 2.2
Identities = 47/244 (19%), Positives = 94/244 (38%), Gaps = 12/244 (4%)
Query: 4 REEKVKIITEEFIENDEDADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEP 63
RE++ K+ +E +++ ++ Q K + +++ R+++ +E + E+ QE
Sbjct: 272 REQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEE 331
Query: 64 VQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEI 123
+ RL + + R + R+REK + R + E QE
Sbjct: 332 KMWRQEERLWEQEKQMREQEQKMRDQEERM----WEQDERLREKEERMREQ-EKMWEQEE 386
Query: 124 PTPRPRRLRSPSKKELETEFGTEPGKEVERTQQE----VDSQSYSRVKFHDSARKIKPKP 179
R+R KK E E +E + Q+E + + + + + + K+ +
Sbjct: 387 KMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQE 446
Query: 180 QVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEM 239
++ E+ + D E +EK R QE++ E+EE K
Sbjct: 447 KMQE---QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMW 503
Query: 240 DEEE 243
D+EE
Sbjct: 504 DQEE 507
Score = 33.1 bits (74), Expect = 2.2
Identities = 49/246 (19%), Positives = 102/246 (41%), Gaps = 34/246 (13%)
Query: 4 REEKVKIITEEFIENDE---DADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNP 60
R+EK++ ++ E +E D + ++ ++ Q + + +E + E+ +
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREK----EERMREQKKMWQQ 532
Query: 61 QEPVQEEPKTRLLSMTVRRGPRSLPPIPSTSRTGFAEFSMRG--RMREKLQAARSKAESA 118
+E ++EE KT+ +T E MR RMRE+ + R + E
Sbjct: 533 EEKMREEKKTQ----------------EQEKKTWDQEEKMREEERMREREKKMREEEEMM 576
Query: 119 LLQEIPTPRPRRLRSPSKKELETEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPK 178
QE +++ +K E E + ++ E+ Q++ + K + + K +
Sbjct: 577 REQE------EKMQEQEEKMREQE--EKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQ 628
Query: 179 PQVPPGFPSAEEAYNFFTFNFDPEPEGSEEKPKARHRAGTNQ-EEEEGEEEEPPAQGGGK 237
Q + E+ ++ E + E++ K R + Q +EE+ E+E QG +
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE 688
Query: 238 EMDEEE 243
+M E+E
Sbjct: 689 KMREQE 694
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 42.7 bits (99), Expect = 0.003
Identities = 43/183 (23%), Positives = 86/183 (46%), Gaps = 16/183 (8%)
Query: 473 SLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIK-VWKEMKSLREFQRFTNTPLK 531
S++ +K E K+++++ K RD E+EKD+ K+ K KE + +E R T P K
Sbjct: 518 SVEVKKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWK 577
Query: 532 LVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAK 591
L++E+AD Y+ +I + E+ K++ +++ K K ++
Sbjct: 578 EFLKEEEAD------PYKFKI---------KEFEDVDPKVKLKDGLVRKEKEKHKDKKKD 622
Query: 592 KKKRKQAAEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLV 651
++K K+ ++ +++ + E+ + P+PP + + A SR P+L+
Sbjct: 623 REKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLL 682
Query: 652 PEL 654
P L
Sbjct: 683 PVL 685
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 42.7 bits (99), Expect = 0.003
Identities = 52/259 (20%), Positives = 105/259 (40%), Gaps = 42/259 (16%)
Query: 442 HQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEK 501
H R+K K +K++ + + E+ + K + R K RD E+EK
Sbjct: 372 HSRDKRKDTREKIKEKERVKEKDREKEREREK--------EREKEKERGKNKDRDKEREK 423
Query: 502 DRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLE 561
DR K+ + RE +R KE + E+ E + + E +
Sbjct: 424 DRE---------KDKEKDRERER----------EKEHEKDRDKEKEKEQDKEKEREKDRS 464
Query: 562 EHTEEYAQKMEEYRTSLQQWKAWRKVQ-RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPS 620
+ +E +K ++ RT + + A R+ + +++++R+++ ++ + PS
Sbjct: 465 KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 524
Query: 621 PPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKR 680
P + ++ R+ ++ R R E S + + ND+ +E ++K
Sbjct: 525 PRSRNKKDKKREKERDHISERRER--------ERSTSMRKSSNDR------DGKEKLEKN 570
Query: 681 SVYLKVLFNNKEVSRTVSR 699
S LK +NKE +VS+
Sbjct: 571 STSLKEKEHNKEPDSSVSK 589
Score = 37.4 bits (85), Expect = 0.12
Identities = 52/222 (23%), Positives = 84/222 (37%), Gaps = 49/222 (22%)
Query: 21 DADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRRG 80
D + + N+ + + P + P A KE+ + Q + + R+G
Sbjct: 248 DRPLKINHSNNAIVKPP--EMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKG 305
Query: 81 PRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKELE 140
RS S SR+ S R R + K +RS S Q+ RR +SP KK +
Sbjct: 306 GRSRSHTRSKSRSSSKSHSRRKRSQSK-HRSRSHNRSRSRQK----DRRRSKSPHKKRSK 360
Query: 141 TEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFD 200
+ R +++ S+S+SR K D+ KIK K +V
Sbjct: 361 S-----------RERRKSRSRSHSRDKRKDTREKIKEKERV------------------- 390
Query: 201 PEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEE 242
+EK + + R E E E E+ +G K+ D+E
Sbjct: 391 ------KEKDREKER------EREKEREKEKERGKNKDRDKE 420
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 42.7 bits (99), Expect = 0.003
Identities = 52/259 (20%), Positives = 105/259 (40%), Gaps = 42/259 (16%)
Query: 442 HQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEK 501
H R+K K +K++ + + E+ + K + R K RD E+EK
Sbjct: 256 HSRDKRKDTREKIKEKERVKEKDREKEREREK--------EREKEKERGKNKDRDKEREK 307
Query: 502 DRTLLKTIIKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLE 561
DR K+ + RE +R KE + E+ E + + E +
Sbjct: 308 DRE---------KDKEKDRERER----------EKEHEKDRDKEKEKEQDKEKEREKDRS 348
Query: 562 EHTEEYAQKMEEYRTSLQQWKAWRKVQ-RAKKKKRKQAAEEHPGDEIAEPYPEEDLVKPS 620
+ +E +K ++ RT + + A R+ + +++++R+++ ++ + PS
Sbjct: 349 KEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPS 408
Query: 621 PPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELSLAGSVTPNDQCPRAEVSRREDVKKR 680
P + ++ R+ ++ R R E S + + ND+ +E ++K
Sbjct: 409 PRSRNKKDKKREKERDHISERRER--------ERSTSMRKSSNDR------DGKEKLEKN 454
Query: 681 SVYLKVLFNNKEVSRTVSR 699
S LK +NKE +VS+
Sbjct: 455 STSLKEKEHNKEPDSSVSK 473
Score = 37.4 bits (85), Expect = 0.12
Identities = 52/222 (23%), Positives = 84/222 (37%), Gaps = 49/222 (22%)
Query: 21 DADMGRQNKNSKVRRQPRKKQPPTAVPKEMVSEKSHLGNPQEPVQEEPKTRLLSMTVRRG 80
D + + N+ + + P + P A KE+ + Q + + R+G
Sbjct: 132 DRPLKINHSNNAIVKPP--EMTPQAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKG 189
Query: 81 PRSLPPIPSTSRTGFAEFSMRGRMREKLQAARSKAESALLQEIPTPRPRRLRSPSKKELE 140
RS S SR+ S R R + K +RS S Q+ RR +SP KK +
Sbjct: 190 GRSRSHTRSKSRSSSKSHSRRKRSQSK-HRSRSHNRSRSRQK----DRRRSKSPHKKRSK 244
Query: 141 TEFGTEPGKEVERTQQEVDSQSYSRVKFHDSARKIKPKPQVPPGFPSAEEAYNFFTFNFD 200
+ R +++ S+S+SR K D+ KIK K +V
Sbjct: 245 S-----------RERRKSRSRSHSRDKRKDTREKIKEKERV------------------- 274
Query: 201 PEPEGSEEKPKARHRAGTNQEEEEGEEEEPPAQGGGKEMDEE 242
+EK + + R E E E E+ +G K+ D+E
Sbjct: 275 ------KEKDREKER------EREKEREKEKERGKNKDRDKE 304
>gi|111955162 5-azacytidine induced 1 isoform b [Homo sapiens]
Length = 1044
Score = 42.4 bits (98), Expect = 0.004
Identities = 51/237 (21%), Positives = 110/237 (46%), Gaps = 21/237 (8%)
Query: 430 KLAQLYDQYLARHQRNKAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIR 489
++ +L + A + + K++++K + ++ GL+PE IQK I +K E+R
Sbjct: 673 EIKKLKELMSATEKARREKWISEKTKKIKEVTVRGLEPE--------IQKLIARHKQEVR 724
Query: 490 QTRKFRDAE-QEKDRTLLKTIIKVWKEMKSL--REFQRFTNTPLKLVLRKEKAD----QK 542
+ + +AE + D + ++ +E++ RE + + ++++A+ ++
Sbjct: 725 RLKSLHEAELLQSDERASQRCLRQAEELREQLEREKEALGQQERERARQRQRAELEELRQ 784
Query: 543 ADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKKRKQA---- 598
EE+ A +A +E + E+ + E T QQ + R+ A + ++++A
Sbjct: 785 QLEESSSALTRALRAEFEKGREEQERRHQMELNTLKQQLELERQAWEAGRTRKEEAWLLN 844
Query: 599 AEEHPGDEIAEPYPEEDLVKPSPPEPTDRAVIEQEVRERAAQSRRRPWEPTLVPELS 655
E+ +EI + +E + E D A+ ++E E+AA+SR + ELS
Sbjct: 845 REQELREEIRKGRDKEIELVIHRLE-ADMALAKEE-SEKAAESRIKRLRDKYEAELS 899
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 42.0 bits (97), Expect = 0.005
Identities = 77/346 (22%), Positives = 137/346 (39%), Gaps = 55/346 (15%)
Query: 271 DYESIHDRLQMEREMLFIPSRQTVPTYKKLPENVQPR-FLEDEGLYTGVRPEVARTNQNI 329
D S+ +LQ +E+L +RQ + KL + + R L+D+ E QN+
Sbjct: 1309 DVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ------LDEEMEAKQNL 1362
Query: 330 MEN----RLLMQDPERRWFGDDGRILALPNPIKPFPSRPPVLTQEQSIKAELETLYKKAV 385
+ + + D +++ + AL K F LTQ+ KA Y K
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA---AAYDKLE 1419
Query: 386 KYVHSSQHVIRSGDPPGNFQLDIDISGLIFTHHPCFSREHVLAAKLAQLYDQYLARHQRN 445
K + Q + + +D+D + ++ K + +DQ LA +
Sbjct: 1420 KTKNRLQQEL------DDLVVDLDNQRQLVSN----------LEKKQRKFDQLLAEEKNI 1463
Query: 446 KAKFLTDKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTL 505
+K+ ++ +A A + E SL + E K E+ +T K AE E L
Sbjct: 1464 SSKYADERDRAEAEA----REKETKALSLARALEEALEAKEELERTNKMLKAEMED---L 1516
Query: 506 LKTIIKVWKEMKSLREFQRFTNTPL---KLVLRKEKADQKADEEA--------------Y 548
+ + V K + L + +R T + K L + + + +A E+A +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 549 EAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKVQRAKKKK 594
E ++QA E EE + +++ EY T L+ + R + A KKK
Sbjct: 1577 ERDLQAR-DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621
Score = 33.9 bits (76), Expect = 1.3
Identities = 34/112 (30%), Positives = 50/112 (44%), Gaps = 15/112 (13%)
Query: 511 KVWKEMKSLREFQRFTNTPLKLVLRKEKADQ------KADEEAYEAEIQAEISELLEEHT 564
K+ KE K L E R ++ L +EKA K + E E++ + E +
Sbjct: 996 KLSKERKLLEE--RISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQEL 1053
Query: 565 EEYAQKME-------EYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 609
E+ +K+E E LQ A K+Q AKK++ QAA DEIA+
Sbjct: 1054 EKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQ 1105
Score = 33.5 bits (75), Expect = 1.7
Identities = 85/400 (21%), Positives = 152/400 (38%), Gaps = 69/400 (17%)
Query: 220 QEEEEGEEEEPPAQGGGKEMDEEELLNGDDAEDFLLGLDHVADDFVAVRPADYESIHDRL 279
+ E E EE + K+ + EE+L+ +A L+ D ++ + L
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEAR-----LEEEEDRGQQLQAERKKMAQQML 953
Query: 280 QMEREMLFIPSRQTVPTYKKLPENVQPRFLEDEGLYTGVRPEVARTNQNIMENRL----- 334
+E ++ + + +K+ + + LEDE L + + ++E R+
Sbjct: 954 DLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTT 1013
Query: 335 -LMQDPERRWFGDDGRILALPNPIKPFPSRPPV-LTQEQSIKAELETLYKKAVKYVHSSQ 392
L ++ E+ + L N + S V L +E+ + ELE L +K
Sbjct: 1014 NLAEEEEKA-----KNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKL-------- 1060
Query: 393 HVIRSGDPPGNFQLDIDISGLIFT-HHPCFSREHVLAAKLAQLYDQYLARHQRNKAKFLT 451
GD + D+ I +E L A LA+L D+ Q+N A
Sbjct: 1061 ----EGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIA---QKNNALKKI 1113
Query: 452 DKLQALRNAVQTGLDPEKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKD--RTLLKTI 509
+L+ + +Q LD E+ ++ QK RD +E + +T L+
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQK---------------RDLGEELEALKTELEDT 1158
Query: 510 IKVWKEMKSLREFQRFTNTPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQ 569
+ + LR + T LK L +E ++EA++Q E +++AQ
Sbjct: 1159 LDSTATQQELRAKREQEVTVLKKALDEET-------RSHEAQVQ--------EMRQKHAQ 1203
Query: 570 KMEEYRTSLQQWKAWRKVQRAKKKKRKQAAEEHPGDEIAE 609
+EE L+Q+K +A K KQ E+ D E
Sbjct: 1204 AVEELTEQLEQFKR----AKANLDKNKQTLEKENADLAGE 1239
Score = 32.0 bits (71), Expect = 5.0
Identities = 24/134 (17%), Positives = 64/134 (47%), Gaps = 2/134 (1%)
Query: 468 EKPHQSLDTIQKTINEYKSEIRQTRKFRDAEQEKDRTLLKTIIKVWKEMKSLREFQRFTN 527
++ ++ ++ NE +E +K A Q+ +R + K+ + +++ +F +
Sbjct: 1757 DRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKS--KFKS 1814
Query: 528 TPLKLVLRKEKADQKADEEAYEAEIQAEISELLEEHTEEYAQKMEEYRTSLQQWKAWRKV 587
T L + + +++ ++EA E + + + ++ +E ++E+ R +Q+K +
Sbjct: 1815 TIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEK 1874
Query: 588 QRAKKKKRKQAAEE 601
A+ K+ K+ EE
Sbjct: 1875 GNARVKQLKRQLEE 1888
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,484,867
Number of Sequences: 37866
Number of extensions: 3358631
Number of successful extensions: 19821
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 484
Number of HSP's that attempted gapping in prelim test: 16218
Number of HSP's gapped (non-prelim): 3097
length of query: 1620
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1504
effective length of database: 13,855,062
effective search space: 20838013248
effective search space used: 20838013248
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.