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Search of human proteins with 195972857
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|195972857 Rho/Rac guanine nucleotide exchange factor 18
isoform b [Homo sapiens]
(1173 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isofo... 2309 0.0
gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isofor... 1994 0.0
gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens] 639 0.0
gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens] 597 e-170
gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens] 597 e-170
gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens] 597 e-170
gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isofor... 467 e-131
gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isoofor... 467 e-131
gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isofor... 462 e-130
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 190 8e-48
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 190 8e-48
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 183 1e-45
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 181 5e-45
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 181 5e-45
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 181 5e-45
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 92 4e-18
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 92 4e-18
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 86 3e-16
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 86 3e-16
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 86 3e-16
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 85 5e-16
gi|38373682 pleckstrin homology domain containing family G membe... 72 3e-12
gi|111154084 pleckstrin homology domain containing family G memb... 72 3e-12
gi|111154088 pleckstrin homology domain containing family G memb... 72 3e-12
gi|111154080 pleckstrin homology domain containing family G memb... 72 3e-12
gi|111154078 pleckstrin homology domain containing family G memb... 72 3e-12
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 70 1e-11
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 69 2e-11
gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens] 69 3e-11
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 69 3e-11
>gi|195972857 Rho/Rac guanine nucleotide exchange factor 18 isoform b
[Homo sapiens]
Length = 1173
Score = 2309 bits (5984), Expect = 0.0
Identities = 1173/1173 (100%), Positives = 1173/1173 (100%)
Query: 1 MVTVGTNILPSRPAASANTAREDAALFSRRIPPRHKNGAAQPGAAPGPGAPGANMGNAHS 60
MVTVGTNILPSRPAASANTAREDAALFSRRIPPRHKNGAAQPGAAPGPGAPGANMGNAHS
Sbjct: 1 MVTVGTNILPSRPAASANTAREDAALFSRRIPPRHKNGAAQPGAAPGPGAPGANMGNAHS 60
Query: 61 KSGDRHSALPGRPELSFYGSFPRKWSENVFLDNELLTSKILSVLRPQSERGFRAGDLRYP 120
KSGDRHSALPGRPELSFYGSFPRKWSENVFLDNELLTSKILSVLRPQSERGFRAGDLRYP
Sbjct: 61 KSGDRHSALPGRPELSFYGSFPRKWSENVFLDNELLTSKILSVLRPQSERGFRAGDLRYP 120
Query: 121 THFLSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQL 180
THFLSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQL
Sbjct: 121 THFLSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQL 180
Query: 181 GPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAES 240
GPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAES
Sbjct: 181 GPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAES 240
Query: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI
Sbjct: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
Query: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE
Sbjct: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
Query: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV
Sbjct: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
Query: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK
Sbjct: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
Query: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD
Sbjct: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
Query: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC
Sbjct: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
Query: 601 PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLE 660
PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLE
Sbjct: 601 PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLE 660
Query: 661 DLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQAEDGGSSTGPPR 720
DLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQAEDGGSSTGPPR
Sbjct: 661 DLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQAEDGGSSTGPPR 720
Query: 721 RAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQV 780
RAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQV
Sbjct: 721 RAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQV 780
Query: 781 VEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFR 840
VEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFR
Sbjct: 781 VEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFR 840
Query: 841 LQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARL 900
LQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARL
Sbjct: 841 LQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARL 900
Query: 901 QEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNT 960
QEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNT
Sbjct: 901 QEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNT 960
Query: 961 APGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTENR 1020
APGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTENR
Sbjct: 961 APGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTENR 1020
Query: 1021 LAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGGKDKGGKSRGSQRWESSASFDLK 1080
LAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGGKDKGGKSRGSQRWESSASFDLK
Sbjct: 1021 LAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGGKDKGGKSRGSQRWESSASFDLK 1080
Query: 1081 QQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAG 1140
QQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAG
Sbjct: 1081 QQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSPSEGFSLKAG 1140
Query: 1141 GTALLPGPPAPSPLPATPLSAKEDASKEDVIFF 1173
GTALLPGPPAPSPLPATPLSAKEDASKEDVIFF
Sbjct: 1141 GTALLPGPPAPSPLPATPLSAKEDASKEDVIFF 1173
>gi|41327769 Rho/Rac guanine nucleotide exchange factor 18 isoform a
[Homo sapiens]
Length = 1015
Score = 1994 bits (5167), Expect = 0.0
Identities = 1015/1015 (100%), Positives = 1015/1015 (100%)
Query: 159 MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE 218
MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE
Sbjct: 1 MTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSLSLTSPNTESIFVE 60
Query: 219 DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 278
DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL
Sbjct: 61 DPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 120
Query: 279 KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV 338
KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV
Sbjct: 121 KIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYV 180
Query: 339 IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI 398
IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI
Sbjct: 181 IQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSI 240
Query: 399 VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS 458
VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS
Sbjct: 241 VRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVS 300
Query: 459 ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI 518
ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI
Sbjct: 301 ECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAI 360
Query: 519 LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI 578
LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI
Sbjct: 361 LLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEI 420
Query: 579 YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL 638
YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL
Sbjct: 421 YTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQL 480
Query: 639 IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI 698
IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI
Sbjct: 481 IAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQGELILKSAMSEIEGIQSLI 540
Query: 699 CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP 758
CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP
Sbjct: 541 CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPP 600
Query: 759 NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI 818
NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI
Sbjct: 601 NSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVI 660
Query: 819 AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE 878
AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE
Sbjct: 661 AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE 720
Query: 879 QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA 938
QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA
Sbjct: 721 QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA 780
Query: 939 QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG 998
QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG
Sbjct: 781 QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSG 840
Query: 999 VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG 1058
VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG
Sbjct: 841 VGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAASTKGG 900
Query: 1059 KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP 1118
KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP
Sbjct: 901 KDKGGKSRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSPAPPPDP 960
Query: 1119 GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF 1173
GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF
Sbjct: 961 GFPAPSPPPADSPSEGFSLKAGGTALLPGPPAPSPLPATPLSAKEDASKEDVIFF 1015
>gi|122937434 Rho-guanine nucleotide exchange factor [Homo sapiens]
Length = 1651
Score = 639 bits (1647), Expect = 0.0
Identities = 378/838 (45%), Positives = 522/838 (62%), Gaps = 46/838 (5%)
Query: 151 PALSRNVGMTVSQKG--GPQPTPSPAGPGTQLGPI----TGEMDEADSAFLKFKQTADDS 204
P+ S VG+ ++ G S + PGT L T E+D + + +D+
Sbjct: 733 PSSSVPVGLPTGRRETVGQVHPLSRSVPGTTLESFRRSATSLESESDHNSCRSRSHSDEL 792
Query: 205 LSL--TSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQD 262
L +SP+TES +ED +SL S++ SD EFEAESWSL VD ++ +Q+++V+KRQD
Sbjct: 793 LQSMGSSPSTESFIMEDVVDSSLWSDLSSDAQEFEAESWSLVVDPSFCNRQEKDVIKRQD 852
Query: 263 VLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLK 322
V++ELMQTE+HH++TL IM +++ + ++EELQ + ++FPC D+LLE H HF +K
Sbjct: 853 VIFELMQTEMHHIQTLFIMSEIFRKGMKEELQLDHSTVDKIFPCLDELLEIHRHFFYSMK 912
Query: 323 ERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQ 382
ERRQES GSDRN+VI +IGD+LVQQFS EN +MK+ YG FC H EAV+ +K L QQ
Sbjct: 913 ERRQESCA-GSDRNFVIDRIGDILVQQFSEENASKMKKIYGEFCCHHKEAVNLFKEL-QQ 970
Query: 383 NKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQA 442
NKKFQN IK + + RR G+ ECILLVTQRITKYPVLVERI+Q T+ TE+++DL +A
Sbjct: 971 NKKFQNFIKLRNSNLLARRRGIPECILLVTQRITKYPVLVERILQYTKERTEEHKDLRKA 1030
Query: 443 LNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRKEDML--QRQLHLE 500
L LIKD+I+ VD KV+E EK Q+ EI K++ K+ +KLKNG FRK+ ++ +R L +
Sbjct: 1031 LCLIKDMIATVDLKVNEYEKNQKWLEILNKIENKTYTKLKNGHVFRKQALMSEERTLLYD 1090
Query: 501 GMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEE 560
G++ WKT +GR KDILA+LLTDVLL LQEKDQKY+FA+VD KP VISLQKLI REVANEE
Sbjct: 1091 GLVYWKTATGRFKDILALLLTDVLLFLQEKDQKYIFAAVDQKPSVISLQKLIAREVANEE 1150
Query: 561 KAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEEERKVVEA 620
+ MFLISAS GPEMYEI+T+SKE+RN WM IQ+AVESCP+E+ G S +E+++ EA
Sbjct: 1151 RGMFLISASSAGPEMYEIHTNSKEERNNWMRRIQQAVESCPEEKGGRTSESDEDKRKAEA 1210
Query: 621 RATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPSETLQG 680
R +++ QE L+ +DQ I L EK IY E+ E+ G ED+ L DP E Q
Sbjct: 1211 RVAKIQQCQEILTNQDQQICAYLEEKLHIYAELGELSGFEDVHLEPHLLIKPDPGEPPQA 1270
Query: 681 ELILKSAMSEIEGIQSLI-CRQLGSANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKN-- 737
+L +A+ E E +Q + Q+G+ + ED S G A+T + +D SPT +
Sbjct: 1271 ASLLAAALKEAESLQVAVKASQMGAVSQSCED---SCGDSVLADTLSSHDVPGSPTASLV 1327
Query: 738 --GSFKKKVSSTDPRPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTV 795
G + S DP + DL +SD+ E + PG+
Sbjct: 1328 TGGREGRGCSDVDPGIQG-----VVTDLAVSDAG------EKVECRNFPGSS-------- 1368
Query: 796 LESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQ 855
+SE++Q IQ L++LL +LQA + QDS++E R +Q++E S L+ ++
Sbjct: 1369 -QSEIIQAIQNLTRLLYSLQAALTIQDSHIEIHRLVLQQQEGLSLGHSILRGGPLQDQKS 1427
Query: 856 RNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLE 915
R+ ++Q EE A + +LQ QL+ EQ+RW R + Q + + LQERE E + E L
Sbjct: 1428 RDADRQHEELANVHQLQHQLQQEQRRWLRRCEQQQRAQATRESWLQERERECQSQEELLL 1487
Query: 916 QERAELERQRQAYQHDLERLREAQRAVERERERLELLRRL------KKQNTAPGALPP 967
+ R EL+ Q Q YQH LERLRE QR VERE+ R+ + L +Q + P L P
Sbjct: 1488 RSRGELDLQLQEYQHSLERLREGQRLVEREQARMRAQQSLLGHWKHGRQRSLPAVLLP 1545
>gi|31563330 A-kinase anchor protein 13 isoform 1 [Homo sapiens]
Length = 2817
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 188 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 240
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 1920 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 1979
Query: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 1980 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 2039
Query: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 2040 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 2099
Query: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 2100 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 2159
Query: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 2160 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 2219
Query: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 2220 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 2279
Query: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 2280 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2339
Query: 601 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 659
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 2340 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 2394
Query: 660 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 709
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 2395 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 2453
Query: 710 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 766
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 2454 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 2500
Query: 767 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 826
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 2501 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 2551
Query: 827 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 886
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 2552 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 2609
Query: 887 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 946
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 2610 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 2669
Query: 947 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 1005
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 2670 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 2715
Query: 1006 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 1055
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 2716 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 2775
Query: 1056 ----------KGGKDKGGKSRGSQRWESSAS 1076
K K K K+ SQ + AS
Sbjct: 2776 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 2806
>gi|21493031 A-kinase anchor protein 13 isoform 3 [Homo sapiens]
Length = 1058
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 188 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 240
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 161 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 220
Query: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 221 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 280
Query: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 281 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 340
Query: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 341 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 400
Query: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 401 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 460
Query: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 461 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 520
Query: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 521 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 580
Query: 601 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 659
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 581 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 635
Query: 660 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 709
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 636 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 694
Query: 710 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 766
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 695 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 741
Query: 767 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 826
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 742 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 792
Query: 827 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 886
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 793 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 850
Query: 887 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 946
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 851 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 910
Query: 947 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 1005
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 911 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 956
Query: 1006 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 1055
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 957 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 1016
Query: 1056 ----------KGGKDKGGKSRGSQRWESSAS 1076
K K K K+ SQ + AS
Sbjct: 1017 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 1047
>gi|21493029 A-kinase anchor protein 13 isoform 2 [Homo sapiens]
Length = 2813
Score = 597 bits (1540), Expect = e-170
Identities = 378/931 (40%), Positives = 549/931 (58%), Gaps = 86/931 (9%)
Query: 188 DEADSAFLKFKQTADDSL---SLTSPNTESIFVE----DPYTASLRSEIESDGHEFEAES 240
DE S KF + DSL S + +TES+ E D L + E + + EAES
Sbjct: 1916 DENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAES 1975
Query: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
WS +D+ + K+QK++VVKRQ+V+YELMQTE HHVRTLKIM VYS+ + +L F + +
Sbjct: 1976 WSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMV 2035
Query: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
+LFPC D+L+ HS F R+ ER++ESL + S++N++I++IGD+LV QFSGEN ER+K+
Sbjct: 2036 EKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKK 2095
Query: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
YG FC HN++V+++K L ++K+FQ +KK + S+VRRLG+ ECILLVTQRITKYPV
Sbjct: 2096 TYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPV 2155
Query: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
L +RI+Q T+ + EDL Q+L+L+KD+I VD+KV+ EK RL EI K D KS +
Sbjct: 2156 LFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMR 2215
Query: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
+K+G F KED+ +++L +G + K +GRLK++ A+LLTD+L+ LQEKDQKY+FAS+D
Sbjct: 2216 MKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLD 2275
Query: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
K VISL+KLIVREVA+EEK +FLIS + PEM E++ SSKE+RN+W+ IQ + +
Sbjct: 2276 QKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTL 2335
Query: 601 -PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 659
DE+EG S EEE+K+++ TR R+ +E+L KDQ I L EK+ I+ +MAE
Sbjct: 2336 NRDEDEGIPSENEEEKKMLD---TRARELKEQLHQKDQKILLLLEEKEMIFRDMAECS-- 2390
Query: 660 EDLPQ-------PRGLFRGGDPSETLQGELILKSAMSEIEGIQSLICRQLGSANGQA--- 709
LP+ PR LFR + E L+G ++KSA++E+E +Q L+ LG G
Sbjct: 2391 TPLPEDCSPTHSPRVLFR-SNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSS 2449
Query: 710 ---EDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKLS 766
+D PRRAETF G+D G K++ + DL+ +
Sbjct: 2450 PIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEE-------------GDDGQDLRRT 2496
Query: 767 DSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVE 826
+SD + +V S+ ++VQ + L +LL LQ V+ QDSY+E
Sbjct: 2497 ESDSGLKKGGNANLVFMLKRNSE---------QVVQSVVHLYELLSALQGVVLQQDSYIE 2547
Query: 827 TQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWERER 886
Q+ + ER L +R + L+EQE+QR+ EKQR++ A L+K Q+Q E++R ERE
Sbjct: 2548 DQKLVLSERALTRSL--SRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREW 2605
Query: 887 QWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERER 946
+ + +EL A L +RE E +Q ++ LE+ER EL++++ YQ+DLERLR AQ+ +ERE+
Sbjct: 2606 EARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQ 2665
Query: 947 ERLEL-LRRLKKQNTAPGALPPDTLAEAQPPSHPPSFNGEGLEGPRVSMLPSGVGPEYAE 1005
E+L RL ++ T + SHP + + + P S PS P
Sbjct: 2666 EQLRREAERLSQRQTE---------RDLCQVSHP---HTKLMRIP--SFFPSPEEPPSPS 2711
Query: 1006 RPEVARRDSAPTE----------NRLAKSDVPIQLLSATNQFQRQAAVQQQIPTKLAAST 1055
P +A+ S +E +R K P +LS+T+Q + Q Q P +AST
Sbjct: 2712 APSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSAST 2771
Query: 1056 ----------KGGKDKGGKSRGSQRWESSAS 1076
K K K K+ SQ + AS
Sbjct: 2772 RLFGLTKPKEKKEKKKKNKTSRSQPGDGPAS 2802
>gi|253735778 Rho/Rac guanine nucleotide exchange factor 2 isoform 2
[Homo sapiens]
Length = 985
Score = 467 bits (1201), Expect = e-131
Identities = 306/823 (37%), Positives = 459/823 (55%), Gaps = 79/823 (9%)
Query: 124 LSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPI 183
L N+ L SV+ K R S P+ S + S++G + + + T I
Sbjct: 99 LKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTN---I 155
Query: 184 TGEM-DEADSAFLKFKQTADDSLSLTSP--NTESIFVEDPYTASLRSEIESDGHEFEAES 240
G DE+ + + DSL++ + + ES+ E+ + L S+ E D +F A+S
Sbjct: 156 AGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADS 215
Query: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
WSLAVD+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL +
Sbjct: 216 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 275
Query: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
LFPC D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M +
Sbjct: 276 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 335
Query: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
Y FCS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+
Sbjct: 336 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 395
Query: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
L+ RI+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ +
Sbjct: 396 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTP 455
Query: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
+ F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D
Sbjct: 456 VPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD 515
Query: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
KP V+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +C
Sbjct: 516 -KPSVVSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTC 572
Query: 601 PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLE 660
P E+ P E+E LR + L KD+ + + L EK ++ EM E
Sbjct: 573 PSREDFPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEE 624
Query: 661 D------LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSA 705
D LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 625 DGGSGMALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPA 683
Query: 706 NGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKL 765
D G +T P A + T NGS + + +D RD
Sbjct: 684 LPLEPDSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN---------- 726
Query: 766 SDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYV 825
G+ SPQ E +QR+ L LL LQA +A QD+ +
Sbjct: 727 ------GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLM 762
Query: 826 ETQ-RAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWER 884
E + + REK R S G EKQ E A L++ + L+ E +R R
Sbjct: 763 EARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRR 822
Query: 885 ERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQA 927
+ + E ARL+E E Q R LE+E E RQ A
Sbjct: 823 LGEERATEAGSLEARLRESE----QARALLEREAEEARRQLAA 861
>gi|15011974 Rho/Rac guanine nucleotide exchange factor 2 isooform 3
[Homo sapiens]
Length = 958
Score = 467 bits (1201), Expect = e-131
Identities = 306/823 (37%), Positives = 459/823 (55%), Gaps = 79/823 (9%)
Query: 124 LSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPI 183
L N+ L SV+ K R S P+ S + S++G + + + T I
Sbjct: 72 LKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTN---I 128
Query: 184 TGEM-DEADSAFLKFKQTADDSLSLTSP--NTESIFVEDPYTASLRSEIESDGHEFEAES 240
G DE+ + + DSL++ + + ES+ E+ + L S+ E D +F A+S
Sbjct: 129 AGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEEVIYSELMSDFEMDEKDFAADS 188
Query: 241 WSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAI 300
WSLAVD+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL +
Sbjct: 189 WSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGVV 248
Query: 301 GRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKE 360
LFPC D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M +
Sbjct: 249 QGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMCK 308
Query: 361 KYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPV 420
Y FCS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP+
Sbjct: 309 TYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYPL 368
Query: 421 LVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK 480
L+ RI+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ +
Sbjct: 369 LISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQTP 428
Query: 481 LKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVD 540
+ F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++D
Sbjct: 429 VPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTLD 488
Query: 541 SKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESC 600
KP V+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +C
Sbjct: 489 -KPSVVSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRTC 545
Query: 601 PDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGLE 660
P E+ P E+E LR + L KD+ + + L EK ++ EM E
Sbjct: 546 PSREDFPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAEE 597
Query: 661 D------LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGSA 705
D LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+ A
Sbjct: 598 DGGSGMALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREPA 656
Query: 706 NGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLKL 765
D G +T P A + T NGS + + +D RD
Sbjct: 657 LPLEPDSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN---------- 699
Query: 766 SDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYV 825
G+ SPQ E +QR+ L LL LQA +A QD+ +
Sbjct: 700 ------GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTLM 735
Query: 826 ETQ-RAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWER 884
E + + REK R S G EKQ E A L++ + L+ E +R R
Sbjct: 736 EARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCRR 795
Query: 885 ERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQA 927
+ + E ARL+E E Q R LE+E E RQ A
Sbjct: 796 LGEERATEAGSLEARLRESE----QARALLEREAEEARRQLAA 834
>gi|253735775 Rho/Rac guanine nucleotide exchange factor 2 isoform 1
[Homo sapiens]
Length = 986
Score = 462 bits (1189), Expect = e-130
Identities = 306/824 (37%), Positives = 459/824 (55%), Gaps = 80/824 (9%)
Query: 124 LSTNSVLASVTASLKEHPRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPI 183
L N+ L SV+ K R S P+ S + S++G + + + T I
Sbjct: 99 LKNNTALQSVSLRSKTTIRERPSSAIYPSDSFRQSLLGSRRGRSSLSLAKSVSTTN---I 155
Query: 184 TGEM-DEADSAFLKFKQTADDSLSLTSP--NTESIFVE-DPYTASLRSEIESDGHEFEAE 239
G DE+ + + DSL++ + + ES+ E + + L S+ E D +F A+
Sbjct: 156 AGHFNDESPLGLRRILSQSTDSLNMRNRTLSVESLIDEAEVIYSELMSDFEMDEKDFAAD 215
Query: 240 SWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKA 299
SWSLAVD+++ ++ K+EV+K+QDV+YEL+QTE+HHVRTLKIM +++ + EEL
Sbjct: 216 SWSLAVDSSFLQQHKKEVMKQQDVIYELIQTELHHVRTLKIMTRLFRTGMLEELHLEPGV 275
Query: 300 IGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMK 359
+ LFPC D+L + H+ FL++L ERR+++L GS RN+VI ++GDLL+ QFSG + E+M
Sbjct: 276 VQGLFPCVDELSDIHTRFLSQLLERRRQALCPGSTRNFVIHRLGDLLISQFSGPSAEQMC 335
Query: 360 EKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYP 419
+ Y FCS H++A+ YK L ++K+FQ I+K+ ++++R GVQECILLVTQRITKYP
Sbjct: 336 KTYSEFCSRHSKALKLYKELYARDKRFQQFIRKVTRPAVLKRHGVQECILLVTQRITKYP 395
Query: 420 VLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSS 479
+L+ RI+Q++ E+ +DLT AL L+K+++S VD + + EKG RL+EI +MD ++ +
Sbjct: 396 LLISRILQHSHGIEEERQDLTTALGLVKELLSNVDEGIYQLEKGARLQEIYNRMDPRAQT 455
Query: 480 KLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASV 539
+ F +E++L+R+L +G L WKT +GR KD+L +L+TDVL+ LQEKDQKY+F ++
Sbjct: 456 PVPGKGPFGREELLRRKLIHDGCLLWKTATGRFKDVLVLLMTDVLVFLQEKDQKYIFPTL 515
Query: 540 DSKPPVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVES 599
D KP V+SLQ LIVR++AN+EK MFLISA+ PEMYE++T+S++DR+ W+ IQ++V +
Sbjct: 516 D-KPSVVSLQNLIVRDIANQEKGMFLISAA--PPEMYEVHTASRDDRSTWIRVIQQSVRT 572
Query: 600 CPDEEEGPFSLPEEERKVVEARATRLRDFQERLSMKDQLIAQSLLEKQQIYLEMAEMGGL 659
CP E+ P E+E LR + L KD+ + + L EK ++ EM
Sbjct: 573 CPSREDFPLIETEDE--------AYLRRIKMELQQKDRALVELLREKVGLFAEMTHFQAE 624
Query: 660 ED------LPQ-PRGLFRGGDPSETLQGELILKSAMSEIEGIQ--------SLICRQLGS 704
ED LP PRGLFR + E+ +GE +L+ A+ E+EG++ L+
Sbjct: 625 EDGGSGMALPTLPRGLFR-SESLESPRGERLLQDAIREVEGLKDLLVGPGVELLLTPREP 683
Query: 705 ANGQAEDGGSSTGPPRRAETFAGYDCTNSPTKNGSFKKKVSSTDPRPRDWRGPPNSPDLK 764
A D G +T P A + T NGS + + +D RD
Sbjct: 684 ALPLEPDSGGNTSPGVTAN-------GEARTFNGSIELCRADSDSSQRDRN--------- 727
Query: 765 LSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSY 824
G+ SPQ E +QR+ L LL LQA +A QD+
Sbjct: 728 -------GNQLRSPQ------------------EEALQRLVNLYGLLHGLQAAVAQQDTL 762
Query: 825 VETQ-RAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRWE 883
+E + + REK R S G EKQ E A L++ + L+ E +R
Sbjct: 763 MEARFPEGPERREKLCRANSRDGEAGRAGAAPVAPEKQATELALLQRQHALLQEELRRCR 822
Query: 884 RERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQA 927
R + + E ARL+E E Q R LE+E E RQ A
Sbjct: 823 RLGEERATEAGSLEARLRESE----QARALLEREAEEARRQLAA 862
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 190 bits (482), Expect = 8e-48
Identities = 135/498 (27%), Positives = 246/498 (49%), Gaps = 50/498 (10%)
Query: 141 PRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQT 200
P L SD S + R +G + S KG + S +MD A A +
Sbjct: 634 PEDLLESDSSRSEIR-LGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSA 692
Query: 201 ADDSLSLTSPNTESIFVEDPYTASL-RSEIESDGHEF----------------------- 236
+ + SL++ + E+ P+T + R IES F
Sbjct: 693 SSSTSSLSTRSLEN--PTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPE 750
Query: 237 -EAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQF 295
+A++W V + + RQ+V+ EL TE H+RTL+++ ++ + +++E
Sbjct: 751 PDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLM 810
Query: 296 SSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENG 355
+ + RLFP +L+E H+ + +K+ R+E +I++I DL++ +F G
Sbjct: 811 PREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKEISDLMLARFDGPAR 862
Query: 356 ERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRI 415
E +++ FCS + A+ K ++ +FQ +++ + RRL +++ I+ QR+
Sbjct: 863 EELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRL 922
Query: 416 TKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDL 475
TKYP+L+E II++TE GT ++E L +A + ++I+ V+ V + E RL ++D
Sbjct: 923 TKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDA 982
Query: 476 KSSSKLKNGLT--FRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQK 533
+ + N L F+ D+ R++ EG L W+ + + D+ +LL D+L+LLQ++D+K
Sbjct: 983 TALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEK 1042
Query: 534 YVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISASLQG-PEMYEIYTS 581
+ S DSK PV+ L +++R VA +++A F+I S G P++YE+
Sbjct: 1043 LLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVAL 1102
Query: 582 SKEDRNAWMAHIQRAVES 599
+ D+N WM ++ AV +
Sbjct: 1103 TSSDKNTWMELLEEAVRN 1120
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 190 bits (482), Expect = 8e-48
Identities = 135/498 (27%), Positives = 246/498 (49%), Gaps = 50/498 (10%)
Query: 141 PRGTLLSDGSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQT 200
P L SD S + R +G + S KG + S +MD A A +
Sbjct: 594 PEDLLESDSSRSEIR-LGRSESLKGREEMKRSRKAENVPRSRSDVDMDAAAEATRLHQSA 652
Query: 201 ADDSLSLTSPNTESIFVEDPYTASL-RSEIESDGHEF----------------------- 236
+ + SL++ + E+ P+T + R IES F
Sbjct: 653 SSSTSSLSTRSLEN--PTPPFTPKMGRRSIESPSLGFCTDTLLPHLLEDDLGQLSDLEPE 710
Query: 237 -EAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQF 295
+A++W V + + RQ+V+ EL TE H+RTL+++ ++ + +++E
Sbjct: 711 PDAQNWQHTVGKDVVAGLTQREIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLM 770
Query: 296 SSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENG 355
+ + RLFP +L+E H+ + +K+ R+E +I++I DL++ +F G
Sbjct: 771 PREELARLFPNLPELIEIHNSWCEAMKKLREEGP--------IIKEISDLMLARFDGPAR 822
Query: 356 ERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRI 415
E +++ FCS + A+ K ++ +FQ +++ + RRL +++ I+ QR+
Sbjct: 823 EELQQVAAQFCSYQSIALELIKTKQRKESRFQLFMQEAESHPQCRRLQLRDLIISEMQRL 882
Query: 416 TKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDL 475
TKYP+L+E II++TE GT ++E L +A + ++I+ V+ V + E RL ++D
Sbjct: 883 TKYPLLLESIIKHTEGGTSEHEKLCRARDQCREILKYVNEAVKQTENRHRLEGYQKRLDA 942
Query: 476 KSSSKLKNGLT--FRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQK 533
+ + N L F+ D+ R++ EG L W+ + + D+ +LL D+L+LLQ++D+K
Sbjct: 943 TALERASNPLAAEFKSLDLTTRKMIHEGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEK 1002
Query: 534 YVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISASLQG-PEMYEIYTS 581
+ S DSK PV+ L +++R VA +++A F+I S G P++YE+
Sbjct: 1003 LLLKCHSKTAVGSSDSKQTFSPVLKLNAVLIRSVATDKRAFFIICTSKLGPPQIYELVAL 1062
Query: 582 SKEDRNAWMAHIQRAVES 599
+ D+N WM ++ AV +
Sbjct: 1063 TSSDKNTWMELLEEAVRN 1080
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 183 bits (464), Expect = 1e-45
Identities = 127/429 (29%), Positives = 219/429 (51%), Gaps = 29/429 (6%)
Query: 228 EIESDGHEFEAE------SWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIM 281
E +S+ +FE + +W V K +KRQ+V+ EL TE HVRTLK++
Sbjct: 750 ESQSEDEQFENDLETDPPNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVL 809
Query: 282 LKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQK 341
+V+ + + E S + ++F +D+L+ H ++K R+ + VI +
Sbjct: 810 DQVFYQRVSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRN------ETSVIDQ 863
Query: 342 IGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRR 401
IG+ L+ FSG E++K FCS A+ K +++ +FQ ++ + + RR
Sbjct: 864 IGEDLLTWFSGPGEEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRR 923
Query: 402 LGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECE 461
L +++ I QR+TKYP+L++ I + TE TE E + +A + + I++ V+ V E E
Sbjct: 924 LQLKDIIPTQMQRLTKYPLLLDNIAKYTEWPTE-REKVKKAADHCRQILNYVNQAVKEAE 982
Query: 462 KGQRLREIAGKMDLKS--SSKLKNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAIL 519
QRL + ++D S S+ N R D+ +R++ EG L WK + D+ +L
Sbjct: 983 NKQRLEDYQRRLDTSSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLL 1042
Query: 520 LTDVLLLLQEKDQKYVF--------ASVDSK---PPVISLQKLIVREVANEEKAMFLISA 568
L D+L+LLQ++D + V ++ DSK PVI L ++VR+VA + KA+F+IS
Sbjct: 1043 LEDILVLLQKQDDRLVLRCHSKILASTADSKHTFSPVIKLSTVLVRQVATDNKALFVISM 1102
Query: 569 SLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPDEEEGPFSLPEE---ERKVVEARATRL 625
S G ++YE+ + ++ W I R S ++ P LP+ E E ++L
Sbjct: 1103 SDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSTKPIPLPQSTPGEGDNDEEDPSKL 1162
Query: 626 RDFQERLSM 634
++ Q +S+
Sbjct: 1163 KEEQHGISV 1171
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1
[Homo sapiens]
Length = 927
Score = 181 bits (458), Expect = 5e-45
Identities = 168/608 (27%), Positives = 270/608 (44%), Gaps = 76/608 (12%)
Query: 149 GSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSL--- 205
G P+ RN+G P PG L P++ + + + + D S
Sbjct: 321 GMPSRDRNIG-----------APGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGP 369
Query: 206 ----SLTSPNT--ESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKRE 256
SL P + E E P E G E E E W V +
Sbjct: 370 MSLESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKS 428
Query: 257 VVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSH 316
VKRQ+V+ EL+ TE HVR L+++ ++ + + E L F + + +FP D+L+E HS
Sbjct: 429 QVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSL 488
Query: 317 FLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHY 376
FL RL +RRQES Y+I++IGD+L+ +F G G ++ FCS + A+
Sbjct: 489 FLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQL 541
Query: 377 KLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDY 436
K +++ +F +++ + RRL +++ I QR+TKYP+L++ I QNTE TE
Sbjct: 542 KAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-R 600
Query: 437 EDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQ 494
E + A ++I+ V+ V + E RL++ ++DL + + + F+ D+ +
Sbjct: 601 EKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITK 660
Query: 495 RQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP--- 543
++L EG L W+ T + ++ +LL D+LLLLQ +D++ + S D K
Sbjct: 661 KKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLR 720
Query: 544 PVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR-------- 595
PV+ L + REVA + KA +++ Q ++YE+ + +R W A I
Sbjct: 721 PVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVP 780
Query: 596 AVESCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIA 640
A S P P S E E +AR R L D R + QL A
Sbjct: 781 APASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAA 840
Query: 641 QSL---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIE 692
+L L +Q+ E G G+ GG S E + L L+ M ++E
Sbjct: 841 TALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLE 900
Query: 693 GIQSLICR 700
++ CR
Sbjct: 901 ELEEEFCR 908
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3
[Homo sapiens]
Length = 879
Score = 181 bits (458), Expect = 5e-45
Identities = 168/608 (27%), Positives = 270/608 (44%), Gaps = 76/608 (12%)
Query: 149 GSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSL--- 205
G P+ RN+G P PG L P++ + + + + D S
Sbjct: 273 GMPSRDRNIG-----------APGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGP 321
Query: 206 ----SLTSPNT--ESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKRE 256
SL P + E E P E G E E E W V +
Sbjct: 322 MSLESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKS 380
Query: 257 VVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSH 316
VKRQ+V+ EL+ TE HVR L+++ ++ + + E L F + + +FP D+L+E HS
Sbjct: 381 QVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSL 440
Query: 317 FLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHY 376
FL RL +RRQES Y+I++IGD+L+ +F G G ++ FCS + A+
Sbjct: 441 FLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQL 493
Query: 377 KLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDY 436
K +++ +F +++ + RRL +++ I QR+TKYP+L++ I QNTE TE
Sbjct: 494 KAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-R 552
Query: 437 EDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQ 494
E + A ++I+ V+ V + E RL++ ++DL + + + F+ D+ +
Sbjct: 553 EKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITK 612
Query: 495 RQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP--- 543
++L EG L W+ T + ++ +LL D+LLLLQ +D++ + S D K
Sbjct: 613 KKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLR 672
Query: 544 PVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR-------- 595
PV+ L + REVA + KA +++ Q ++YE+ + +R W A I
Sbjct: 673 PVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVP 732
Query: 596 AVESCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIA 640
A S P P S E E +AR R L D R + QL A
Sbjct: 733 APASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAA 792
Query: 641 QSL---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIE 692
+L L +Q+ E G G+ GG S E + L L+ M ++E
Sbjct: 793 TALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLE 852
Query: 693 GIQSLICR 700
++ CR
Sbjct: 853 ELEEEFCR 860
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2
[Homo sapiens]
Length = 912
Score = 181 bits (458), Expect = 5e-45
Identities = 168/608 (27%), Positives = 270/608 (44%), Gaps = 76/608 (12%)
Query: 149 GSPALSRNVGMTVSQKGGPQPTPSPAGPGTQLGPITGEMDEADSAFLKFKQTADDSL--- 205
G P+ RN+G P PG L P++ + + + + D S
Sbjct: 306 GMPSRDRNIG-----------APGQDTPGVSLHPLSLDSPDREPGADAPLELGDSSPQGP 354
Query: 206 ----SLTSPNT--ESIFVEDPYTASLRSEIESDGHEFEAES---WSLAVDAAYAKKQKRE 256
SL P + E E P E G E E E W V +
Sbjct: 355 MSLESLAPPESTDEGAETESPEPGD-EGEPGRSGLELEPEEPPGWRELVPPDTLHSLPKS 413
Query: 257 VVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSH 316
VKRQ+V+ EL+ TE HVR L+++ ++ + + E L F + + +FP D+L+E HS
Sbjct: 414 QVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMAECLFFPLEELQNIFPSLDELIEVHSL 473
Query: 317 FLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHY 376
FL RL +RRQES Y+I++IGD+L+ +F G G ++ FCS + A+
Sbjct: 474 FLDRLMKRRQES-------GYLIEEIGDVLLARFDGAEGSWFQKISSRFCSRQSFALEQL 526
Query: 377 KLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDY 436
K +++ +F +++ + RRL +++ I QR+TKYP+L++ I QNTE TE
Sbjct: 527 KAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRLTKYPLLLQSIGQNTEEPTE-R 585
Query: 437 EDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGL--TFRKEDMLQ 494
E + A ++I+ V+ V + E RL++ ++DL + + + F+ D+ +
Sbjct: 586 EKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDLSHLRQSSDPMLSEFKNLDITK 645
Query: 495 RQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFAS--------VDSKP--- 543
++L EG L W+ T + ++ +LL D+LLLLQ +D++ + S D K
Sbjct: 646 KKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDERLLLKSHSRTLTPTPDGKTMLR 705
Query: 544 PVISLQKLIVREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQR-------- 595
PV+ L + REVA + KA +++ Q ++YE+ + +R W A I
Sbjct: 706 PVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQTVSERKNWCALITETAGSLKVP 765
Query: 596 AVESCPDEEEGPFSLPE------------EERKVVEARATR-LRDFQE--RLSMKDQLIA 640
A S P P S E E +AR R L D R + QL A
Sbjct: 766 APASRPKPRPSPSSTREPLLSSSENGNGGRETSPADARTERILSDLLPFCRPGPEGQLAA 825
Query: 641 QSL---LEKQQIYLEMAEMGGLEDLPQPRGLFRGGDPS-----ETLQGELILKSAMSEIE 692
+L L +Q+ E G G+ GG S E + L L+ M ++E
Sbjct: 826 TALRKVLSLKQLLFPAEEDNGAGPPRDGDGVPGGGPLSPARTQEIQENLLSLEETMKQLE 885
Query: 693 GIQSLICR 700
++ CR
Sbjct: 886 ELEEEFCR 893
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 91.7 bits (226), Expect = 4e-18
Identities = 92/382 (24%), Positives = 177/382 (46%), Gaps = 42/382 (10%)
Query: 259 KRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFL 318
KRQ ++EL+QTE ++ L+++++V+ + + E + + +F +L+ +++ L
Sbjct: 1182 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1241
Query: 319 ARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKL 378
L+ R++ E+ +Q IGD+L + S + Y FCS + +
Sbjct: 1242 KALRVRKKTGGEK-----MPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQ 1290
Query: 379 LLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYED 438
++ F+ +KK+ + + + + +L QRIT+YP+L+ I++NT D+
Sbjct: 1291 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1350
Query: 439 LTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK--LKNGLTFRKEDMLQRQ 496
L AL +++ SQV+ V E E RL I + + ++ + N LT + R+
Sbjct: 1351 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT---NCLGPRK 1407
Query: 497 LHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQ-------KYVFASVDS------KP 543
L G L +KT S K++ L D LLL Q + +F+S + K
Sbjct: 1408 LLHSGKL-YKTKSN--KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKT 1464
Query: 544 PVISLQKLI-VREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPD 602
P+ + L+ + + ++ +F IS +Y + T + +R AW+ I+ A E D
Sbjct: 1465 PIFLNEVLVKLPTDPSSDEPVFHIS---HIDRVYTLRTDNINERTAWVQKIKAASEQYID 1521
Query: 603 EEEGPFSLPEEERKVVEARATR 624
E+ ++ K +AR+ +
Sbjct: 1522 TEK------KKREKAYQARSQK 1537
Score = 61.2 bits (147), Expect = 5e-09
Identities = 51/130 (39%), Positives = 79/130 (60%), Gaps = 14/130 (10%)
Query: 832 IQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRW-ERERQWQH 890
+QE E Q +L T E +R+ N+E+ E LEK + L +QQR ER+ Q +
Sbjct: 350 MQEEEPQKKLPVT-----FEDKRKANYERGNME---LEKRRQALMEQQQREAERKAQKEK 401
Query: 891 QELERAGARLQEREGEAR-QLRERLEQERAELERQRQAYQH-DLERLREAQRAVERERER 948
+E ER LQE+E + + +L +RLE++R ELERQR+ + D+ER A++ +ER+R R
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQR-ELERQREEERRKDIERREAAKQELERQR-R 459
Query: 949 LELLRRLKKQ 958
LE R+++Q
Sbjct: 460 LE-WERIRRQ 468
Score = 43.1 bits (100), Expect = 0.002
Identities = 52/187 (27%), Positives = 81/187 (43%), Gaps = 21/187 (11%)
Query: 775 EESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQE 834
EE PQ + P T D R + ++ Q L+ Q A + + E + ++
Sbjct: 352 EEEPQK-KLPVTFEDKRKANYERGNM--ELEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
Query: 835 REKQFRLQSTRGNLLLEQERQRNFEKQREER---------AALEKLQSQLRHEQQRWERE 885
RE Q + + L E+QR E+QREE AA ++L+ Q R E WER
Sbjct: 409 RELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE---WERI 465
Query: 886 RQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERE 945
R+ QEL R QE E +L + + ELE +Q RL++ + + +
Sbjct: 466 RR---QELLNQKNREQE---EIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQ 519
Query: 946 RERLELL 952
+ LE+L
Sbjct: 520 KTELEVL 526
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/126 (23%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
Query: 825 VETQRAAIQEREKQFRLQSTRGNLLLEQ-ERQRNFEKQREERAALEKLQSQLRHEQQRWE 883
+E QR ++RE++ R R ++ ERQR E +R R L +++ + E R
Sbjct: 426 LEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLN 485
Query: 884 RERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVE 943
+++ H ELE + Q+ G + +R + + ++ ELE + ++ +++ Q+ ++
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQ 545
Query: 944 RERERL 949
+ +L
Sbjct: 546 EYQNKL 551
Score = 32.3 bits (72), Expect = 2.7
Identities = 40/169 (23%), Positives = 74/169 (43%), Gaps = 30/169 (17%)
Query: 795 VLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQST--RGNLLLEQ 852
VL+ + I + QL LQ ++ Y+ ++ + ER K + +T G LL +
Sbjct: 525 VLDKQCDLEIMEIKQLQQELQEY-QNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHK 583
Query: 853 ERQRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRE 912
++ EK E+L +L+ + E+E ++L E + QL+E
Sbjct: 584 ---KSLEK--------EELCQRLKEQLDALEKE----------TASKLSEMDSFNNQLKE 622
Query: 913 RLEQERAELERQRQAYQHDLERLREAQRAVERERERLELLRRLKKQNTA 961
E + Q Y+ ++L+E ER+RLEL+++ K ++ A
Sbjct: 623 LRETYNTQQLALEQLYKIKRDKLKEI------ERKRLELMQKKKLEDEA 665
Score = 31.6 bits (70), Expect = 4.6
Identities = 34/158 (21%), Positives = 75/158 (47%), Gaps = 15/158 (9%)
Query: 797 ESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLL--LEQER 854
+ EL QR L + L L+ A + S +++ ++E + + Q L +++++
Sbjct: 588 KEELCQR---LKEQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDK 644
Query: 855 QRNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERL 914
+ E++R E +KL+ + + ++ +E W+ + L + Q+R E + +
Sbjct: 645 LKEIERKRLELMQKKKLEDEAARKAKQG-KENLWK-ENLRKEEEEKQKRLQEEKTQEKIQ 702
Query: 915 EQERAELERQRQAYQHDLERLREAQRAVERERERLELL 952
E+ER E+QR+ ++ +A E++RE +L
Sbjct: 703 EEERKAEEKQRKD--------KDTLKAEEKKRETASVL 732
Score = 30.8 bits (68), Expect = 7.9
Identities = 24/87 (27%), Positives = 32/87 (36%), Gaps = 10/87 (11%)
Query: 1077 FDLKQQLLLNKLMGKD-----ESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSP 1131
F + +L+ KL G+ + SP++ R P+ P P PP A P
Sbjct: 79 FSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA--P 136
Query: 1132 SEGFSLKAGGTALLPGPPAPSPLPATP 1158
S GT L PP P P P
Sbjct: 137 ITSLSSATSGTNL---PPLMMPTPLVP 160
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 91.7 bits (226), Expect = 4e-18
Identities = 92/382 (24%), Positives = 177/382 (46%), Gaps = 42/382 (10%)
Query: 259 KRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFL 318
KRQ ++EL+QTE ++ L+++++V+ + + E + + +F +L+ +++ L
Sbjct: 1209 KRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLL 1268
Query: 319 ARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKL 378
L+ R++ E+ +Q IGD+L + S + Y FCS + +
Sbjct: 1269 KALRVRKKTGGEK-----MPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQ 1317
Query: 379 LLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYED 438
++ F+ +KK+ + + + + +L QRIT+YP+L+ I++NT D+
Sbjct: 1318 KTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSS 1377
Query: 439 LTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSK--LKNGLTFRKEDMLQRQ 496
L AL +++ SQV+ V E E RL I + + ++ + N LT + R+
Sbjct: 1378 LKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLT---NCLGPRK 1434
Query: 497 LHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQ-------KYVFASVDS------KP 543
L G L +KT S K++ L D LLL Q + +F+S + K
Sbjct: 1435 LLHSGKL-YKTKSN--KELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKT 1491
Query: 544 PVISLQKLI-VREVANEEKAMFLISASLQGPEMYEIYTSSKEDRNAWMAHIQRAVESCPD 602
P+ + L+ + + ++ +F IS +Y + T + +R AW+ I+ A E D
Sbjct: 1492 PIFLNEVLVKLPTDPSSDEPVFHIS---HIDRVYTLRTDNINERTAWVQKIKAASEQYID 1548
Query: 603 EEEGPFSLPEEERKVVEARATR 624
E+ ++ K +AR+ +
Sbjct: 1549 TEK------KKREKAYQARSQK 1564
Score = 61.2 bits (147), Expect = 5e-09
Identities = 51/130 (39%), Positives = 79/130 (60%), Gaps = 14/130 (10%)
Query: 832 IQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHEQQRW-ERERQWQH 890
+QE E Q +L T E +R+ N+E+ E LEK + L +QQR ER+ Q +
Sbjct: 350 MQEEEPQKKLPVT-----FEDKRKANYERGNME---LEKRRQALMEQQQREAERKAQKEK 401
Query: 891 QELERAGARLQEREGEAR-QLRERLEQERAELERQRQAYQH-DLERLREAQRAVERERER 948
+E ER LQE+E + + +L +RLE++R ELERQR+ + D+ER A++ +ER+R R
Sbjct: 402 EEWERKQRELQEQEWKKQLELEKRLEKQR-ELERQREEERRKDIERREAAKQELERQR-R 459
Query: 949 LELLRRLKKQ 958
LE R+++Q
Sbjct: 460 LE-WERIRRQ 468
Score = 43.1 bits (100), Expect = 0.002
Identities = 52/187 (27%), Positives = 81/187 (43%), Gaps = 21/187 (11%)
Query: 775 EESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQE 834
EE PQ + P T D R + ++ Q L+ Q A + + E + ++
Sbjct: 352 EEEPQK-KLPVTFEDKRKANYERGNM--ELEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
Query: 835 REKQFRLQSTRGNLLLEQERQRNFEKQREE---------RAALEKLQSQLRHEQQRWERE 885
RE Q + + L E+QR E+QREE AA ++L+ Q R E WER
Sbjct: 409 RELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLE---WERI 465
Query: 886 RQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERE 945
R+ QEL R QE E +L + + ELE +Q RL++ + + +
Sbjct: 466 RR---QELLNQKNREQE---EIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQ 519
Query: 946 RERLELL 952
+ LE+L
Sbjct: 520 KTELEVL 526
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/126 (23%), Positives = 63/126 (50%), Gaps = 1/126 (0%)
Query: 825 VETQRAAIQEREKQFRLQSTRGNLLLEQ-ERQRNFEKQREERAALEKLQSQLRHEQQRWE 883
+E QR ++RE++ R R ++ ERQR E +R R L +++ + E R
Sbjct: 426 LEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLN 485
Query: 884 RERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVE 943
+++ H ELE + Q+ G + +R + + ++ ELE + ++ +++ Q+ ++
Sbjct: 486 SKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQ 545
Query: 944 RERERL 949
+ +L
Sbjct: 546 EYQNKL 551
Score = 33.5 bits (75), Expect = 1.2
Identities = 31/157 (19%), Positives = 73/157 (46%), Gaps = 22/157 (14%)
Query: 796 LESELVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQ 855
++ ++Q + +L L NL ++ TQ+ A+++ K +++++
Sbjct: 625 MDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYK------------IKRDKL 672
Query: 856 RNFEKQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLE 915
+ E++R E +KL+ + + ++ +E W+ + L + Q+R E + + E
Sbjct: 673 KEIERKRLELMQKKKLEDEAARKAKQG-KENLWK-ENLRKEEEEKQKRLQEEKTQEKIQE 730
Query: 916 QERAELERQRQAYQHDLERLREAQRAVERERERLELL 952
+ER E+QR+ ++ +A E++RE +L
Sbjct: 731 EERKAEEKQRKD--------KDTLKAEEKKRETASVL 759
Score = 30.8 bits (68), Expect = 7.9
Identities = 24/87 (27%), Positives = 32/87 (36%), Gaps = 10/87 (11%)
Query: 1077 FDLKQQLLLNKLMGKD-----ESTSRNRRSLSPILPGRHSPAPPPDPGFPAPSPPPADSP 1131
F + +L+ KL G+ + SP++ R P+ P P PP A P
Sbjct: 79 FSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA--P 136
Query: 1132 SEGFSLKAGGTALLPGPPAPSPLPATP 1158
S GT L PP P P P
Sbjct: 137 ITSLSSATSGTNL---PPLMMPTPLVP 160
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2
[Homo sapiens]
Length = 532
Score = 85.5 bits (210), Expect = 3e-16
Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)
Query: 196 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 255
+F QT S+S S + I P++ R+ S +++ WS D +
Sbjct: 68 RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 124
Query: 256 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 315
+ +KRQ+ ++EL Q E + LK+ K Y + + + + + ++F D L+ H
Sbjct: 125 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 184
Query: 316 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 375
L++L++ R+ +GS + +G +LV Y +CS A
Sbjct: 185 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 227
Query: 376 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 432
K LL +Q+ + Q+ +++ R+L + + + R+ KYP+L+ I+++T
Sbjct: 228 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 286
Query: 433 TEDYEDLTQALNLIKDIISQVDAKVSECE 461
D + L +A+N+I+ I+++++ K E E
Sbjct: 287 NPDQQHLEEAINIIQGIVAEINTKTGESE 315
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1
[Homo sapiens]
Length = 558
Score = 85.5 bits (210), Expect = 3e-16
Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)
Query: 196 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 255
+F QT S+S S + I P++ R+ S +++ WS D +
Sbjct: 94 RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 150
Query: 256 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 315
+ +KRQ+ ++EL Q E + LK+ K Y + + + + + ++F D L+ H
Sbjct: 151 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 210
Query: 316 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 375
L++L++ R+ +GS + +G +LV Y +CS A
Sbjct: 211 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 253
Query: 376 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 432
K LL +Q+ + Q+ +++ R+L + + + R+ KYP+L+ I+++T
Sbjct: 254 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 312
Query: 433 TEDYEDLTQALNLIKDIISQVDAKVSECE 461
D + L +A+N+I+ I+++++ K E E
Sbjct: 313 NPDQQHLEEAINIIQGIVAEINTKTGESE 341
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 85.5 bits (210), Expect = 3e-16
Identities = 63/269 (23%), Positives = 125/269 (46%), Gaps = 24/269 (8%)
Query: 196 KFKQTADDSLSLTSPNTESIFVEDPYTASLRSEIESDGHEFEAESWSLAVDAAYAKKQKR 255
+F QT S+S S + I P++ R+ S +++ WS D +
Sbjct: 62 RFSQTLQRSISFRSESRPDILAPRPWS---RNAAPSSTKRRDSKLWSETFDVCVNQMLTS 118
Query: 256 EVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHS 315
+ +KRQ+ ++EL Q E + LK+ K Y + + + + + ++F D L+ H
Sbjct: 119 KEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHE 178
Query: 316 HFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSH 375
L++L++ R+ +GS + +G +LV Y +CS A
Sbjct: 179 ELLSQLRDVRKP---DGSTEH-----VGPILVGWLP------CLSSYDSYCSNQVAA--- 221
Query: 376 YKLLL---QQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAG 432
K LL +Q+ + Q+ +++ R+L + + + R+ KYP+L+ I+++T
Sbjct: 222 -KALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPND 280
Query: 433 TEDYEDLTQALNLIKDIISQVDAKVSECE 461
D + L +A+N+I+ I+++++ K E E
Sbjct: 281 NPDQQHLEEAINIIQGIVAEINTKTGESE 309
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 84.7 bits (208), Expect = 5e-16
Identities = 80/351 (22%), Positives = 148/351 (42%), Gaps = 27/351 (7%)
Query: 259 KRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQFSSKAIGRLFPCADDLLETHSHFL 318
KRQ ++EL+ TE ++V L+++ +++ + L E + K + +F +L+ + L
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296
Query: 319 ARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKL 378
L+ R++ S E+ ++ IGD+L Q + Y FCS + +
Sbjct: 1297 KALRVRKKMSGEK-----MPVKMIGDILSAQLPH------MQPYIRFCSRQLNGAALIQQ 1345
Query: 379 LLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYED 438
+ F+ +K++ + + + IL QR+T+YP++++ I++NT D+
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405
Query: 439 LTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKLKNGLTFRK-EDMLQRQL 497
L AL +++ SQV+ V E E RL I + + L L F + L +
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEG---LSEQLVFNSVTNCLGPRK 1462
Query: 498 HLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVA 557
L +K S K++ L D LLL Q + P +LQ + +
Sbjct: 1463 FLHSGKLYKAKSN--KELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPI 1520
Query: 558 NEEKAMFLISASLQGPE----------MYEIYTSSKEDRNAWMAHIQRAVE 598
+ + + G E +Y + S +R AW+ I+ A E
Sbjct: 1521 FLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESINERTAWVQKIKAASE 1571
Score = 64.3 bits (155), Expect = 6e-10
Identities = 47/127 (37%), Positives = 73/127 (57%), Gaps = 6/127 (4%)
Query: 836 EKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQ--SQLRHEQQRWERERQWQ---H 890
E + R RGNL LE+ RQ E+QR+E+ L +L+ Q R E++R E+ER+ Q
Sbjct: 351 EDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQERKERERQEQERKRQLELE 410
Query: 891 QELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERLE 950
++LE+ ++RE E R+ ER E + ELERQRQ + + R +E +E+E +
Sbjct: 411 KQLEKQRELERQREEERRKEIERREAAKRELERQRQ-LEWERNRRQELLNQRNKEQEDIV 469
Query: 951 LLRRLKK 957
+L+ KK
Sbjct: 470 VLKAKKK 476
Score = 49.3 bits (116), Expect = 2e-05
Identities = 51/222 (22%), Positives = 98/222 (44%), Gaps = 40/222 (18%)
Query: 765 LSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQR-------IQTLSQLLLNLQAV 817
+S + + E P V+E + + +LP E + + ++ Q LL Q
Sbjct: 320 ISSTSVDQRLPEEP-VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQR- 377
Query: 818 IAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQ--ERQRNFEKQREE--RAALEKLQS 873
Q+ + +RA + +E++ + Q + L LE+ E+QR E+QREE R +E+ ++
Sbjct: 378 -KEQERLAQLERAEQERKERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREA 436
Query: 874 QLRH-EQQR---WERERQWQ----------------------HQELERAGARLQEREGEA 907
R E+QR WER R+ + ELE + + EG+
Sbjct: 437 AKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKL 496
Query: 908 RQLRERLEQERAELERQRQAYQHDLERLREAQRAVERERERL 949
+ +R RL +R E+E ++ + + + Q+ ++ ++ L
Sbjct: 497 QDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQML 538
Score = 42.0 bits (97), Expect = 0.003
Identities = 42/162 (25%), Positives = 72/162 (44%), Gaps = 16/162 (9%)
Query: 800 LVQRIQTLSQLLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFE 859
L+ Q L+ L +Q H+DS V +RA K+ Q R L E
Sbjct: 541 LIPEKQILNDQLKQVQQNSLHRDSLVTLKRAL---EAKELARQHLRDQL---------DE 588
Query: 860 KQREERAALEKLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERA 919
++E R+ L+++ Q E Q+L++ + ER + Q R+ +E E+
Sbjct: 589 VEKETRSKLQEIDI---FNNQLKELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQ 645
Query: 920 ELERQRQAYQHDLERLREAQRAVERERER-LELLRRLKKQNT 960
+ E QR+A + D + L Q+ E +R R L +LK++ +
Sbjct: 646 KEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHEEEKLKREES 687
>gi|38373682 pleckstrin homology domain containing family G member 5
isoform a [Homo sapiens]
Length = 1006
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 224 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 278
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 355
Query: 279 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 329
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 330 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 389
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 416 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 462
Query: 390 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 449
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 463 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 521
Query: 450 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 493
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 522 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 581
Query: 494 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 553
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 582 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 638
Query: 554 REV 556
RE+
Sbjct: 639 REL 641
>gi|111154084 pleckstrin homology domain containing family G member
5 isoform b [Homo sapiens]
Length = 1083
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 224 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 278
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 375 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 432
Query: 279 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 329
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 433 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 492
Query: 330 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 389
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 493 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 539
Query: 390 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 449
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 540 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 598
Query: 450 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 493
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 599 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 658
Query: 494 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 553
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 659 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 715
Query: 554 REV 556
RE+
Sbjct: 716 REL 718
>gi|111154088 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 224 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 278
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 355
Query: 279 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 329
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 330 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 389
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 416 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 462
Query: 390 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 449
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 463 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 521
Query: 450 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 493
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 522 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 581
Query: 494 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 553
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 582 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 638
Query: 554 REV 556
RE+
Sbjct: 639 REL 641
>gi|111154080 pleckstrin homology domain containing family G member
5 isoform a [Homo sapiens]
Length = 1006
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 224 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 278
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 298 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 355
Query: 279 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 329
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 356 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 415
Query: 330 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 389
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 416 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 462
Query: 390 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 449
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 463 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 521
Query: 450 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 493
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 522 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 581
Query: 494 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 553
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 582 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 638
Query: 554 REV 556
RE+
Sbjct: 639 REL 641
>gi|111154078 pleckstrin homology domain containing family G member
5 isoform c [Homo sapiens]
Length = 1062
Score = 72.0 bits (175), Expect = 3e-12
Identities = 86/363 (23%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 224 SLRSEIESDGHEFEA-----ESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTL 278
S E + D E A +SW +D +K R +Q+ ++EL+ TE ++R L
Sbjct: 354 SWEEEYDEDEDEDNACLRLEDSWRELIDGH--EKLTRRQCHQQEAVWELLHTEASYIRKL 411
Query: 279 KIMLKVYSRAL---QEELQFSSKAIGRLFPCADDLLETHSHFLARL------KERRQESL 329
++++ ++ L QE RLF ++ + H A + K RR +L
Sbjct: 412 RVIINLFLCCLLNLQESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRAL 471
Query: 330 EEGSDRNYVIQKIGDLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNKKFQNL 389
+ D + G L + Y +C + + + LL+ N F+
Sbjct: 472 LQPGDFLKGFKMFGSLF-------------KPYIRYCMEEEGCMEYMRGLLRDNDLFRAY 518
Query: 390 IKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDI 449
I +RL + + + QR+TKYP+L++ +++ TE E + + ++
Sbjct: 519 ITWAEKHPQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTEE-PRAKEAVVAMIGSVERF 577
Query: 450 ISQVDAKVSECEKGQRLREIAGKMD----LKSSSKLKNGL--TFRKEDML---------- 493
I V+A + + ++ QRL + ++D ++SSS + L F D+
Sbjct: 578 IHHVNACMRQRQERQRLAAVVSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEE 637
Query: 494 QRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIV 553
RQL LEG L K D+ L TD LLL K K + +PP++ + K++
Sbjct: 638 TRQLLLEGSLRMKEGKDSKMDVYCFLFTD--LLLVTKAVKKAERTRVIRPPLL-VDKIVC 694
Query: 554 REV 556
RE+
Sbjct: 695 REL 697
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 70.1 bits (170), Expect = 1e-11
Identities = 96/392 (24%), Positives = 159/392 (40%), Gaps = 67/392 (17%)
Query: 750 RPRDWRGPPNSPDLKLSDSDIPGSSEESPQVVEAPGTESDPRLPTVLESELVQRIQTLSQ 809
R R RG + + + S GS EE +V P E +P + E TL +
Sbjct: 308 RTRKKRGEKDETEYEYS-----GSEEEEEEV---PEQEGEPSSIVNVPGE-----STLRR 354
Query: 810 LLLNLQAVIAHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALE 869
L LQ + + Q+ +E+Q R Q LL ERQ+ E+Q+E+R LE
Sbjct: 355 DFLRLQQENKERSEALRRQQLL---QEQQLREQEEYKRQLLA-ERQKRIEQQKEQRRRLE 410
Query: 870 KLQSQLRHEQQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQ 929
EQQR ERE + Q + +R + ++R E + R + E+ER E +++ +
Sbjct: 411 --------EQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVE 462
Query: 930 HDLERLREAQRAVERERERLELLRRLKKQNTA-------------PGALPPDTLAEAQPP 976
+ E +R R +E E+ LE+L++ Q A PP ++P
Sbjct: 463 REQEYIR---RQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPS 519
Query: 977 SHPPSFNGEGLEGPRVSMLPSGVGPEYAERPEVARRDSAPTEN----RLAKSDVPIQLLS 1032
H P P+ P+ E +R S ++ R+ + VP + S
Sbjct: 520 FHAPE--------PKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSES 571
Query: 1033 ATN--------QFQRQAAVQQQIPTKLAASTKGGKD---KGGKSRGSQRWESSASFDLKQ 1081
+N QR A Q + T + +D +G + SQ + +++ ++
Sbjct: 572 FSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEP 631
Query: 1082 QLL---LNKLMGKDESTSRNRRSLSPILPGRH 1110
+LL + KL+ + S S + S S PG H
Sbjct: 632 RLLWERVEKLVPRPGSGSSSGSSNSGSQPGSH 663
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 69.3 bits (168), Expect = 2e-11
Identities = 74/356 (20%), Positives = 155/356 (43%), Gaps = 24/356 (6%)
Query: 819 AHQDSYVETQRAAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAALEKLQSQLRHE 878
A + ++ Q+ A+Q++++Q + Q + L +Q++Q+ ++ + +++A+++ + +
Sbjct: 147 ATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQ 206
Query: 879 QQRWERERQWQHQELERAGARLQEREGEARQLRERLEQERAELERQRQAYQHDLERLREA 938
QQ+ ++++Q Q ++ Q+ + + +QL+ + + + ++Q+Q Q ++ +A
Sbjct: 207 QQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQA 266
Query: 939 QRAVERERERLELLRRLKKQNTAPGALPPDTLAEAQPPSH--PPSFNGEGLEGPRVSMLP 996
Q +++ +++ P P L + H PP + + P P
Sbjct: 267 QPPIQQP--------PMQQPQPPPSQALPQQLQQMHHTQHHQPPP---QPQQPPVAQNQP 315
Query: 997 SGVGPEYAERPEVARRDSAPTENRLAKSDVPIQLLSATNQFQR---QAAVQQQIPTKLAA 1053
S + P+ +P V++ + P ++ + P++ + A Q+ Q VQQQ A
Sbjct: 316 SQLPPQSQTQPLVSQAQALP--GQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTA 373
Query: 1054 STKGGKDKGGK-SRGSQRWESSASFDLKQQLLLNKLMGKDESTSRNRRSLSPILPGRHSP 1112
G + S+ S SS S + Q + S + S P P
Sbjct: 374 QAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGP 433
Query: 1113 APPPDPGFPAPSPPPADSP-----SEGFSLKAGGTALLPGPPAPSPLPATPLSAKE 1163
AP P P+PSP P+ SP + FS+ + G P P+ PA A+E
Sbjct: 434 APSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEE 489
>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
Length = 766
Score = 68.9 bits (167), Expect = 3e-11
Identities = 77/368 (20%), Positives = 160/368 (43%), Gaps = 39/368 (10%)
Query: 245 VDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLKVYSRALQEELQ---FSSKAIG 301
+D + K+ E K + EL+ TE +V L ++ +V+ L EE F ++ +
Sbjct: 193 LDQHHEMKETNEQ-KLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVN 251
Query: 302 RLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIGDLLVQQFSGENGERMKEK 361
++F + HS FL E+R + E ++QK+ L +
Sbjct: 252 KIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFL-------------KM 298
Query: 362 YGVFCSGHNEAVSHYKLLLQQNKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVL 421
YG + G + A+ K + ++ +F++++++I I L +Q +L QRI +Y +L
Sbjct: 299 YGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEML 358
Query: 422 VERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSECEKGQRLREIAGKMDLKSSSKL 481
++ ++ + D+ D ++L +I S ++ + + E ++L EI + +
Sbjct: 359 LKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVN 418
Query: 482 KNGLTFRKEDMLQRQLHLEGMLCWKTTSGRLKDILAILLTDVLLLLQEKDQKYVFASVDS 541
+ ++ +L+ L + TS + + + L ++LL K F+ V S
Sbjct: 419 PSNELIKEGQILK--------LAARNTSAQERYL--FLFNNMLLYCVPK-----FSLVGS 463
Query: 542 KPPV---ISLQKLIVREVANEEKAMFLISASLQGPE-MYEIYTSSKEDRNAWMAHIQRAV 597
K V + + + + E NEE + + + G E E+ SS +D+ W+ +Q +
Sbjct: 464 KFTVRTRVGIDGMKIVETQNEE---YPHTFQVSGKERTLELQASSAQDKEEWIKALQETI 520
Query: 598 ESCPDEEE 605
++ E
Sbjct: 521 DAFHQRHE 528
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1
[Homo sapiens]
Length = 596
Score = 68.9 bits (167), Expect = 3e-11
Identities = 54/241 (22%), Positives = 105/241 (43%), Gaps = 21/241 (8%)
Query: 224 SLRSEIESDGHEFEAESWSLAVDAAYAKKQKREVVKRQDVLYELMQTEVHHVRTLKIMLK 283
S RS + + + WS +D + ++RQ+ +YE+ + E + LK+ K
Sbjct: 139 SSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARK 198
Query: 284 VYSRALQEELQFSSKAIGRLFPCADDLLETHSHFLARLKERRQESLEEGSDRNYVIQKIG 343
Y + + S + + +F D + H L R+ E + + +++IG
Sbjct: 199 AYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKP--------DGTVEQIG 250
Query: 344 DLLVQQFSGENGERMKEKYGVFCSGHNEAVSHYKLLLQQNK---KFQNLIKKIGNFSIVR 400
+LV N Y +CS A K LL Q K + Q+ +++ R
Sbjct: 251 HILVSWLPRLNA------YRGYCSNQLAA----KALLDQKKQDPRVQDFLQRCLESPFSR 300
Query: 401 RLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYEDLTQALNLIKDIISQVDAKVSEC 460
+L + + + R+ KYP+L++ I+++T D + L A+ +I+ ++S ++ K E
Sbjct: 301 KLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGES 360
Query: 461 E 461
E
Sbjct: 361 E 361
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,779,784
Number of Sequences: 37866
Number of extensions: 2812596
Number of successful extensions: 41345
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 631
Number of HSP's successfully gapped in prelim test: 1378
Number of HSP's that attempted gapping in prelim test: 19130
Number of HSP's gapped (non-prelim): 13702
length of query: 1173
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1060
effective length of database: 13,968,660
effective search space: 14806779600
effective search space used: 14806779600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.