Search of human proteins with 195947369

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|195947369 junction-mediating and regulatory protein [Homo
sapiens]
         (988 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|195947369 junction-mediating and regulatory protein [Homo sap...  1952   0.0  
gi|122937271 WAS protein homolog associated with actin, golgi me...   456   e-128
gi|169208040 PREDICTED: similar to WAS protein homolog associate...   132   2e-30
gi|169208753 PREDICTED: similar to WHDC1-like protein 1 [Homo sa...   111   4e-24
gi|239745156 PREDICTED: similar to WAS protein homolog associate...   111   4e-24
gi|239745125 PREDICTED: similar to WAS protein homolog associate...   110   7e-24
gi|56549694 enabled homolog isoform a [Homo sapiens]                   71   4e-12
gi|39930375 enabled homolog isoform b [Homo sapiens]                   71   4e-12
gi|150170670 piccolo isoform 2 [Homo sapiens]                          69   2e-11
gi|150378539 piccolo isoform 1 [Homo sapiens]                          69   2e-11
gi|47132519 Ras association and pleckstrin homology domains 1 is...    68   4e-11
gi|33356148 formin-like 1 [Homo sapiens]                               67   8e-11
gi|52485606 formin-like 2 [Homo sapiens]                               67   1e-10
gi|158534059 formin binding protein 4 [Homo sapiens]                   65   3e-10
gi|148746195 trichohyalin [Homo sapiens]                               64   5e-10
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]         63   1e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                        62   3e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                        62   3e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                         62   3e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                         62   3e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                         62   3e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens]                         62   3e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                         62   3e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                         62   3e-09
gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens]           62   3e-09
gi|126090663 zinc finger homeodomain 4 [Homo sapiens]                  61   6e-09
gi|150378503 leiomodin 2 (cardiac) [Homo sapiens]                      61   6e-09
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   60   1e-08
gi|194294521 intersectin 2 isoform 1 [Homo sapiens]                    59   3e-08
gi|194294525 intersectin 2 isoform 2 [Homo sapiens]                    59   3e-08

>gi|195947369 junction-mediating and regulatory protein [Homo
           sapiens]
          Length = 988

 Score = 1952 bits (5057), Expect = 0.0
 Identities = 988/988 (100%), Positives = 988/988 (100%)

Query: 1   MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSRE 60
           MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSRE
Sbjct: 1   MSFALEETLESDWVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSRE 60

Query: 61  QAGARGGAEAGGAASDGSRGPGSPAGRGRPEATASATLVRSPGPRRSSAWAEGGSPRSTR 120
           QAGARGGAEAGGAASDGSRGPGSPAGRGRPEATASATLVRSPGPRRSSAWAEGGSPRSTR
Sbjct: 61  QAGARGGAEAGGAASDGSRGPGSPAGRGRPEATASATLVRSPGPRRSSAWAEGGSPRSTR 120

Query: 121 SLLGDPRLRSPGSKGAESRLRSPVRAKPIPGQKTSEADDAAGAAAAAARPAPREAQVSSV 180
           SLLGDPRLRSPGSKGAESRLRSPVRAKPIPGQKTSEADDAAGAAAAAARPAPREAQVSSV
Sbjct: 121 SLLGDPRLRSPGSKGAESRLRSPVRAKPIPGQKTSEADDAAGAAAAAARPAPREAQVSSV 180

Query: 181 RIVSASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRA 240
           RIVSASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRA
Sbjct: 181 RIVSASGTVSEEIEVLEMVKEDEAPLALSDAEQPPPATELESPAEECSWAGLFSFQDLRA 240

Query: 241 VHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTC 300
           VHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTC
Sbjct: 241 VHQQLCSVNSQLEPCLPVFPEEPSGMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTC 300

Query: 301 GWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLD 360
           GWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLD
Sbjct: 301 GWKILSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLD 360

Query: 361 LYQLEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQK 420
           LYQLEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQK
Sbjct: 361 LYQLEDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQK 420

Query: 421 EDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKL 480
           EDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKL
Sbjct: 421 EDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKL 480

Query: 481 QYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV 540
           QYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV
Sbjct: 481 QYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV 540

Query: 541 QFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQ 600
           QFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQ
Sbjct: 541 QFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQ 600

Query: 601 KLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREK 660
           KLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREK
Sbjct: 601 KLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREK 660

Query: 661 LHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDH 720
           LHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDH
Sbjct: 661 LHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDH 720

Query: 721 CDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSEL 780
           CDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSEL
Sbjct: 721 CDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSEL 780

Query: 781 PPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKD 840
           PPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKD
Sbjct: 781 PPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKD 840

Query: 841 LPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKR 900
           LPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKR
Sbjct: 841 LPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKR 900

Query: 901 GSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPDTDPLTRSI 960
           GSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPDTDPLTRSI
Sbjct: 901 GSFHLKKVEQRTLPPFPDEDDSNNILAQIRKGVKLKKVQKDVLRESFTLLPDTDPLTRSI 960

Query: 961 HEALRRIKEASPESEDEEEALPCTDWEN 988
           HEALRRIKEASPESEDEEEALPCTDWEN
Sbjct: 961 HEALRRIKEASPESEDEEEALPCTDWEN 988


>gi|122937271 WAS protein homolog associated with actin, golgi
           membranes and microtubules [Homo sapiens]
          Length = 809

 Score =  456 bits (1173), Expect = e-128
 Identities = 287/788 (36%), Positives = 420/788 (53%), Gaps = 56/788 (7%)

Query: 214 PPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPS--------- 264
           P P  + E+     SWAGL S   LR  H+QL ++   LE C P  P E           
Sbjct: 63  PEPEPKPEAAVSPSSWAGLLSAAGLRGAHRQLAALWPPLERCFPRLPPELDVGGGGAWGL 122

Query: 265 --GMWTVLFGGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYYES 322
             G+W +L+       E  +  LC QL+ YLG   D CG   +   LF       +  ES
Sbjct: 123 GLGLWALLWPTRAGPGEAALQELCGQLERYLGAAADGCGGATVRDALFPAEGGAADC-ES 181

Query: 323 LSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQY 382
             E R++        A  R+++++  H    +MV L+++YQ EDEAY  L    T  +QY
Sbjct: 182 PREFRERALRARWVEADARLRQVIQGHGKANTMVALMNVYQEEDEAYQELVTVATMFFQY 241

Query: 383 LLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVK 442
           LLQPFR MRE+A L +  I  S++ D LGPRR+ +L+KE  +W R+A  AV+SIQD+TV 
Sbjct: 242 LLQPFRAMREVATLCKLDILKSLDEDDLGPRRVVALEKEAEEWTRRAEEAVVSIQDITVN 301

Query: 443 YFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQR 502
           YF+ T KA   +   M  D K+FG+A+WA A  R+EKLQ  +++ETLQ+MRAKE+CL  +
Sbjct: 302 YFKETVKALAGMQKEMEQDAKRFGQAAWATAIPRLEKLQLMLARETLQLMRAKELCLNHK 361

Query: 503 KHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRL 562
           +  ++ +M+ L    +    +D+LE  +Y++QL+LYEV+FEILK EE+LLT QL+S+KRL
Sbjct: 362 RAEIQGKMEDLPEQEKNTNVVDELEIQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRL 421

Query: 563 ISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSY 622
           I EK+DEVVYYD  E+ E +   + +      +  E+++L+++ +QLE++RGR+ AK++ 
Sbjct: 422 IKEKQDEVVYYDPCENPEELKVIDCVVGLQDDKNLEVKELRRQCQQLESKRGRICAKRAS 481

Query: 623 LRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDR 682
           LR++K+ C   H  ++QQ        R HH++Q+KR+K+ +EE++K  W++QERQ+TL R
Sbjct: 482 LRSRKDQCKENHRFRLQQAEESIRYSRQHHSIQMKRDKIKEEEQKKKEWINQERQKTLQR 541

Query: 683 LRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRV 742
           LR+FK +            RLA + R  + S    E    +LPS L  +          V
Sbjct: 542 LRSFKDK------------RLAQSVRNTSGS----EPVAPNLPSDLSQQMCLPASHAVSV 585

Query: 743 KRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINP 802
               S+ T    L +  +         S         +P  + +P+ +   +  S +   
Sbjct: 586 IHPSSRKTRGVPLSEAGNVK-------SPKCQNCHGNIPVQVFVPVGD---QTHSKSSEE 635

Query: 803 LPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSASAPSAHL 862
           L  P PP PPPPPPPPPPPPPPPL     S      ++L        R P     P   +
Sbjct: 636 LSLPPPPPPPPPPPPPPPPPPPPLRALSSSSQAATHQNL------GFRAPVKDDQPRPLV 689

Query: 863 FDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDS 922
            +S           +  + L+       MDEVLASL+ G   L+KVE   + P P    +
Sbjct: 690 CES--------PAERPRDSLESFSCPGSMDEVLASLRHGRAPLRKVEVPAVRP-PHASIN 740

Query: 923 NNILAQIRKGVKLKKVQKDV---LRESFTLLPDTDPLTRSIHEALRRIKEASPESEDEEE 979
            +ILA IR+GVKLKKV  D+        T    T  L RSI  AL+RIK  S +SE++ +
Sbjct: 741 EHILAAIRQGVKLKKVHPDLGPNPSSKPTSNRRTSDLERSIKAALQRIKRVSADSEEDSD 800

Query: 980 ALPCTDWE 987
                 W+
Sbjct: 801 EQDPGQWD 808



 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 31/57 (54%), Positives = 40/57 (70%), Gaps = 4/57 (7%)

Query: 13 WVAVRPHVFDEREKHKFVFIVAWNEIEGKFAITCHNRTAQRQRSGSREQAGARGGAE 69
          WV VR  +F E E+H+  F+VAWN  EGKFA+TCH+RTAQ++R     + GAR G E
Sbjct: 12 WVPVREGLFAEPERHRLRFLVAWNGAEGKFAVTCHDRTAQQRRL----REGARLGPE 64


>gi|169208040 PREDICTED: similar to WAS protein homolog associated
           with actin, golgi membranes and microtubules isoform 1
           [Homo sapiens]
          Length = 131

 Score =  132 bits (332), Expect = 2e-30
 Identities = 65/125 (52%), Positives = 95/125 (76%)

Query: 458 MRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGT 517
           M  D K+FG+A+WA A  R+EKL+  +++ETLQ+MRAKE+ L +++  ++ +M+ L    
Sbjct: 5   MEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKELYLNRKRAEIQGKMEDLPEQE 64

Query: 518 EAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYE 577
           + I  +D+LE  +Y++QL+LYEV+FEILK EE+LLT QL+S+KRLI EK+DEVVYYD  E
Sbjct: 65  KNINVVDELEMQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKEKQDEVVYYDPCE 124

Query: 578 SMEAM 582
           S E +
Sbjct: 125 SPEEL 129


>gi|169208753 PREDICTED: similar to WHDC1-like protein 1 [Homo
           sapiens]
          Length = 130

 Score =  111 bits (277), Expect = 4e-24
 Identities = 54/116 (46%), Positives = 85/116 (73%)

Query: 451 QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
           Q  +   M  D K+FG+A+WA A  R+EKL+  +++ETLQ+MRAKE+ L +++  ++ +M
Sbjct: 14  QLGMQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKELYLNRKRAEIQGKM 73

Query: 511 QSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEK 566
           + L    + I  +D+LE  +Y++QL+LYEV+FEILK EE+LLT QL+S+KRLI ++
Sbjct: 74  EDLPEQEKNINVVDELEMQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKDE 129


>gi|239745156 PREDICTED: similar to WAS protein homolog associated
           with actin, golgi membranes and microtubules isoform 2
           [Homo sapiens]
          Length = 130

 Score =  111 bits (277), Expect = 4e-24
 Identities = 54/116 (46%), Positives = 85/116 (73%)

Query: 451 QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
           Q  +   M  D K+FG+A+WA A  R+EKL+  +++ETLQ+MRAKE+ L +++  ++ +M
Sbjct: 14  QLGMQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKELYLNRKRAEIQGKM 73

Query: 511 QSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEK 566
           + L    + I  +D+LE  +Y++QL+LYEV+FEILK EE+LLT QL+S+KRLI ++
Sbjct: 74  EDLPEQEKNINVVDELEMQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKDE 129


>gi|239745125 PREDICTED: similar to WAS protein homolog associated
           with actin, golgi membranes and microtubules [Homo
           sapiens]
          Length = 130

 Score =  110 bits (275), Expect = 7e-24
 Identities = 54/116 (46%), Positives = 84/116 (72%)

Query: 451 QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
           Q  +   M  D K+FG+A+WA A  R+EKL+  +++ETLQ+MRAKE+ L +++  ++ +M
Sbjct: 14  QLGMQKEMEQDVKRFGQAAWATAIPRLEKLKLMLAQETLQLMRAKELYLNRKRAEIQGKM 73

Query: 511 QSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEK 566
           + L    + I  +D+LE  +Y++QL+LYEV+FEILK EE+LLT QL+S+KRLI  +
Sbjct: 74  EDLPEQEKNINVVDELEMQFYEIQLELYEVKFEILKNEEILLTTQLDSLKRLIKNE 129


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 70/253 (27%), Positives = 112/253 (44%), Gaps = 29/253 (11%)

Query: 586 EEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIE 645
           +E      L+RE L++ + +  +LE  R R+  ++      ++  + +  ++ +++ R+E
Sbjct: 148 QEQQRQKELERERLERERMERERLE--RERLERERLERERLEQEQLERERQERERQERLE 205

Query: 646 DEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAH 705
            + R     +L+R++  D E ++     QER+R L+RL   +Q    Q  L+  +L    
Sbjct: 206 RQERLERQERLERQERLDRERQER----QERER-LERLERERQERERQEQLEREQLEWER 260

Query: 706 ARR-KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLT 764
            RR   AA+P   E   +S+      +    E G     + P++T   Q +V      L 
Sbjct: 261 ERRISSAAAPASVETPLNSVLG----DSSASEPGLQAASQ-PAETPSQQGIV------LG 309

Query: 765 QLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPP----PPPP 820
            L     P       LPP  +   +     P      PLPS  PP PPPPPP     PPP
Sbjct: 310 PLAPPPPP------PLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPP 363

Query: 821 PPPPPLPVAKDSG 833
           PPPPP P    SG
Sbjct: 364 PPPPPAPPLPASG 376


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 70/253 (27%), Positives = 112/253 (44%), Gaps = 29/253 (11%)

Query: 586 EEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIE 645
           +E      L+RE L++ + +  +LE  R R+  ++      ++  + +  ++ +++ R+E
Sbjct: 148 QEQQRQKELERERLERERMERERLE--RERLERERLERERLEQEQLERERQERERQERLE 205

Query: 646 DEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAH 705
            + R     +L+R++  D E ++     QER+R L+RL   +Q    Q  L+  +L    
Sbjct: 206 RQERLERQERLERQERLDRERQER----QERER-LERLERERQERERQEQLEREQLEWER 260

Query: 706 ARR-KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLT 764
            RR   AA+P   E   +S+      +    E G     + P++T   Q +V      L 
Sbjct: 261 ERRISSAAAPASVETPLNSVLG----DSSASEPGLQAASQ-PAETPSQQGIV------LG 309

Query: 765 QLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPP----PPPP 820
            L     P       LPP  +   +     P      PLPS  PP PPPPPP     PPP
Sbjct: 310 PLAPPPPP------PLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPP 363

Query: 821 PPPPPLPVAKDSG 833
           PPPPP P    SG
Sbjct: 364 PPPPPAPPLPASG 376


>gi|150170670 piccolo isoform 2 [Homo sapiens]
          Length = 4935

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 56/176 (31%), Positives = 72/176 (40%), Gaps = 20/176 (11%)

Query: 727  VLQVEEKTEEVGEGRVKRGPSQTT---EPQSLV------QLEDTSLTQLEA--TSLPLSG 775
            VL+     +E+   R K   S+T     P S++      QL  T  T  E      P S 
Sbjct: 2316 VLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQ 2375

Query: 776  VTSELPPTISLPLLNNNL-EPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGP 834
            + S  P   SLP          S+ I+  P P PP PPPPPPPPPPPPPPPLP      P
Sbjct: 2376 LPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKP 2435

Query: 835  ETLEKDLPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSP 890
              L K        +K    S    +  LFD+   +     LR     + R   ++P
Sbjct: 2436 TILPK--------KKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP 2483



 Score = 34.7 bits (78), Expect = 0.45
 Identities = 55/226 (24%), Positives = 84/226 (37%), Gaps = 40/226 (17%)

Query: 659 EKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQE 718
           E   +E  +K   V +E+ +    ++   Q+ P + I K          ++G     LQ+
Sbjct: 183 EASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPK----------QQGPGRDPLQQ 232

Query: 719 DHCDSLPSVLQVEE-KTEEVGEGRVKRGPSQT--TEPQSLVQLEDTSLTQLEATSL---- 771
           D      S  Q E+ K++  G G+  +GP+QT  T+   L    D S  Q +   +    
Sbjct: 233 DGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGE 292

Query: 772 ------------PLSGVTSELPPTISLPLLNNNLEPCSVTINP--LPSPL---PPTPPPP 814
                       P+   T   PP        +   P      P  L  PL   P T  PP
Sbjct: 293 SVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPP 352

Query: 815 PPPP--PPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSASAP 858
             PP    PP  PL  AK    +T  +    K  +E+  PK+ + P
Sbjct: 353 VQPPGTTKPPAQPLGPAKPPAQQTGSE----KPSSEQPGPKALAQP 394



 Score = 30.4 bits (67), Expect = 8.6
 Identities = 18/53 (33%), Positives = 21/53 (39%), Gaps = 3/53 (5%)

Query: 804 PSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPET---LEKDLPRKEGNEKRIPK 853
           PS LP    PPP  P P  PPP        P       K  P++ G  K  P+
Sbjct: 470 PSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQ 522



 Score = 30.4 bits (67), Expect = 8.6
 Identities = 27/90 (30%), Positives = 48/90 (53%), Gaps = 11/90 (12%)

Query: 578  SMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEK 637
            ++E   E+EE+      + EEL K Q+K R++E ++ + S+KKS  ++K E+   +  E+
Sbjct: 1769 TIEDSSEEEELR-----EEEELLKEQEKQREIEQQQRKSSSKKS-KKDKDELRAQRRRER 1822

Query: 638  IQ----QRTRIEDEYRTHHTVQ-LKREKLH 662
             +      + IED   T    Q  + E+LH
Sbjct: 1823 PKTPPSNLSPIEDASPTEELRQAAEMEELH 1852



 Score = 30.4 bits (67), Expect = 8.6
 Identities = 22/93 (23%), Positives = 36/93 (38%), Gaps = 14/93 (15%)

Query: 746  PSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPS 805
            P  T+   +++  +  ++     T+ PL    + L  T    +L +N  P +      P 
Sbjct: 2428 PPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTA---VLRSNGLPVTRICTTAPP 2484

Query: 806  PLPPTPP-----------PPPPPPPPPPPPPLP 827
            P+PP P            P P  PP  P P +P
Sbjct: 2485 PVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIP 2517


>gi|150378539 piccolo isoform 1 [Homo sapiens]
          Length = 5142

 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 56/176 (31%), Positives = 72/176 (40%), Gaps = 20/176 (11%)

Query: 727  VLQVEEKTEEVGEGRVKRGPSQTT---EPQSLV------QLEDTSLTQLEA--TSLPLSG 775
            VL+     +E+   R K   S+T     P S++      QL  T  T  E      P S 
Sbjct: 2316 VLEAYRDKKELEAERTKSSLSETVFDHPPSSVIALPMKEQLSTTYFTSGETFGQEKPASQ 2375

Query: 776  VTSELPPTISLPLLNNNL-EPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGP 834
            + S  P   SLP          S+ I+  P P PP PPPPPPPPPPPPPPPLP      P
Sbjct: 2376 LPSGSPSVSSLPAKPRPFFRSSSLDISAQPPPPPPPPPPPPPPPPPPPPPPLPPPTSPKP 2435

Query: 835  ETLEKDLPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSP 890
              L K        +K    S    +  LFD+   +     LR     + R   ++P
Sbjct: 2436 TILPK--------KKLTVASPVTTATPLFDAVTTLETTAVLRSNGLPVTRICTTAP 2483



 Score = 34.7 bits (78), Expect = 0.45
 Identities = 55/226 (24%), Positives = 84/226 (37%), Gaps = 40/226 (17%)

Query: 659 EKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQE 718
           E   +E  +K   V +E+ +    ++   Q+ P + I K          ++G     LQ+
Sbjct: 183 EASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPK----------QQGPGRDPLQQ 232

Query: 719 DHCDSLPSVLQVEE-KTEEVGEGRVKRGPSQT--TEPQSLVQLEDTSLTQLEATSL---- 771
           D      S  Q E+ K++  G G+  +GP+QT  T+   L    D S  Q +   +    
Sbjct: 233 DGTPKSISSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGE 292

Query: 772 ------------PLSGVTSELPPTISLPLLNNNLEPCSVTINP--LPSPL---PPTPPPP 814
                       P+   T   PP        +   P      P  L  PL   P T  PP
Sbjct: 293 SVKPSLPSPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPP 352

Query: 815 PPPP--PPPPPPPLPVAKDSGPETLEKDLPRKEGNEKRIPKSASAP 858
             PP    PP  PL  AK    +T  +    K  +E+  PK+ + P
Sbjct: 353 VQPPGTTKPPAQPLGPAKPPAQQTGSE----KPSSEQPGPKALAQP 394



 Score = 30.4 bits (67), Expect = 8.6
 Identities = 18/53 (33%), Positives = 21/53 (39%), Gaps = 3/53 (5%)

Query: 804 PSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPET---LEKDLPRKEGNEKRIPK 853
           PS LP    PPP  P P  PPP        P       K  P++ G  K  P+
Sbjct: 470 PSQLPGPAKPPPQQPGPAKPPPQQPGSAKPPSQQPGSTKPPPQQPGPAKPSPQ 522



 Score = 30.4 bits (67), Expect = 8.6
 Identities = 27/90 (30%), Positives = 48/90 (53%), Gaps = 11/90 (12%)

Query: 578  SMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEK 637
            ++E   E+EE+      + EEL K Q+K R++E ++ + S+KKS  ++K E+   +  E+
Sbjct: 1769 TIEDSSEEEELR-----EEEELLKEQEKQREIEQQQRKSSSKKS-KKDKDELRAQRRRER 1822

Query: 638  IQ----QRTRIEDEYRTHHTVQ-LKREKLH 662
             +      + IED   T    Q  + E+LH
Sbjct: 1823 PKTPPSNLSPIEDASPTEELRQAAEMEELH 1852



 Score = 30.4 bits (67), Expect = 8.6
 Identities = 22/93 (23%), Positives = 36/93 (38%), Gaps = 14/93 (15%)

Query: 746  PSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPS 805
            P  T+   +++  +  ++     T+ PL    + L  T    +L +N  P +      P 
Sbjct: 2428 PPPTSPKPTILPKKKLTVASPVTTATPLFDAVTTLETTA---VLRSNGLPVTRICTTAPP 2484

Query: 806  PLPPTPP-----------PPPPPPPPPPPPPLP 827
            P+PP P            P P  PP  P P +P
Sbjct: 2485 PVPPKPSSIPSGLVFTHRPEPSKPPIAPKPVIP 2517


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 68.2 bits (165), Expect = 4e-11
 Identities = 36/78 (46%), Positives = 48/78 (61%), Gaps = 8/78 (10%)

Query: 757 QLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPP 816
           QLE++S  ++E+ + P    TS +PP    P +   + P + +  P P PLPP PPPPPP
Sbjct: 586 QLEESSKARMESMNRPY---TSLVPPLSPQPKI---VTPYTAS-QPSP-PLPPPPPPPPP 637

Query: 817 PPPPPPPPPLPVAKDSGP 834
           PPPPPPPPP P+   S P
Sbjct: 638 PPPPPPPPPPPLPSQSAP 655



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 39/124 (31%), Positives = 49/124 (39%), Gaps = 25/124 (20%)

Query: 742 VKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTIN 801
           VK+  SQ   P +   +E   L  + A   P S      PP +         +P S+   
Sbjct: 862 VKQIASQFPPPPTPPAMESQPLKPVPANVAPQS------PPAVKA---KPKWQPSSI--- 909

Query: 802 PLPSP-LPPTPP-------PPPP-----PPPPPPPPPLPVAKDSGPETLEKDLPRKEGNE 848
           P+PSP  PP PP       PPPP     PPPPPPP   P    SG    +       G +
Sbjct: 910 PVPSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGK 969

Query: 849 KRIP 852
           K  P
Sbjct: 970 KPPP 973



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 3/65 (4%)

Query: 781 PPTISLPLLNNNLEPCSV-TINPLPSPLPPTPPPPPPPPPPPPP--PPLPVAKDSGPETL 837
           P   SLP  +    P  +  +  +    PPTPPPPPP P P PP  PP P+     P + 
Sbjct: 732 PCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTST 791

Query: 838 EKDLP 842
           +   P
Sbjct: 792 KTVAP 796



 Score = 39.3 bits (90), Expect = 0.018
 Identities = 34/109 (31%), Positives = 46/109 (42%), Gaps = 19/109 (17%)

Query: 746 PSQTTEPQSLVQLEDTSLTQLEA-TSLPLSGVTSELPPTIS-LPLLNNNLEPCSVTINPL 803
           P  +  P  L   +   +TQ+   T  P   + + LPP     PL+       + T+ P+
Sbjct: 738 PQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPV 797

Query: 804 PSPL-PPTPPPPPPP------------PPPPPPPPLPVAKDSGPETLEK 839
            +   PPTP PP PP            PP PP PP+PV     P TL K
Sbjct: 798 VTQAAPPTPTPPVPPAKKQPAFPASYIPPSPPTPPVPVP----PPTLPK 842



 Score = 38.5 bits (88), Expect = 0.031
 Identities = 16/37 (43%), Positives = 18/37 (48%)

Query: 807 LPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPR 843
           +PP    PPPPPPPPPP P        P      LP+
Sbjct: 703 VPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQ 739



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 12/63 (19%)

Query: 776 VTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPP----------PPPPPP 825
           VT   PPT + P+     +P +   + +P P PPTPP P PPP           PPP P 
Sbjct: 798 VTQAAPPTPTPPVPPAKKQP-AFPASYIP-PSPPTPPVPVPPPTLPKQQSFCAKPPPSPL 855

Query: 826 LPV 828
            PV
Sbjct: 856 SPV 858



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 46/157 (29%), Positives = 63/157 (40%), Gaps = 18/157 (11%)

Query: 84   PAGRGRPEATASATLVRS--PGPRRSSAWAEGG-----SPRSTRSLLGDPRLRSPGSKGA 136
            PA    P  TAS T  +S  PG + S   + GG     +P+   S+        P  K  
Sbjct: 936  PAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKPPPTPQRNSSIKSSSGAEHPEPK-- 993

Query: 137  ESRLRSPVRAKPIPGQKTSEADDAAGAAAAAARPAPREAQVSSVRI--VSASGTVSEEIE 194
               + S V     P +  S + +     AA   P P +  +S V +  V   G VS +  
Sbjct: 994  RPSVDSLVSKFTPPAESGSPSKETLPPPAAP--PKPGKLNLSGVNLPGVLQQGCVSAKAP 1051

Query: 195  VL-----EMVKEDEAPLALSDAEQPPPATELESPAEE 226
            VL     + V E  +P + SD   PPP TEL  P  E
Sbjct: 1052 VLSGRGKDSVVEFPSPPSDSDFPPPPPETELPLPPIE 1088



 Score = 34.7 bits (78), Expect = 0.45
 Identities = 17/34 (50%), Positives = 17/34 (50%), Gaps = 17/34 (50%)

Query: 808 PPTPP-------------PP----PPPPPPPPPP 824
           PPTPP             PP    PPPPPPPPPP
Sbjct: 686 PPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPP 719



 Score = 34.7 bits (78), Expect = 0.45
 Identities = 15/26 (57%), Positives = 15/26 (57%)

Query: 797 SVTINPLPSPLPPTPPPPPPPPPPPP 822
           SV    L  P    PPPPPPPPPP P
Sbjct: 696 SVKPQILVPPNGVVPPPPPPPPPPTP 721



 Score = 32.7 bits (73), Expect = 1.7
 Identities = 29/90 (32%), Positives = 36/90 (40%), Gaps = 15/90 (16%)

Query: 781 PPTISLPLLNNNL-EPCSVTINPLPSPLPPTPPPP-------PPPPPPP---PPPPLPVA 829
           PPT  +P+    L +  S    P PSPL P P          PPPP PP     P  PV 
Sbjct: 828 PPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPPAMESQPLKPVP 887

Query: 830 KDSGPETLEKDLPRKEGNEKRIPKSASAPS 859
            +  P++     P  +   K  P S   PS
Sbjct: 888 ANVAPQS----PPAVKAKPKWQPSSIPVPS 913



 Score = 32.3 bits (72), Expect = 2.3
 Identities = 26/97 (26%), Positives = 31/97 (31%), Gaps = 36/97 (37%)

Query: 781 PPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPP-----------------------PPP 817
           PPT  +    +      V  N +  P PP PPPP                       PPP
Sbjct: 686 PPTPPVMQSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPP 745

Query: 818 P-------------PPPPPPPLPVAKDSGPETLEKDL 841
           P             PP PPPP P+     P+   K L
Sbjct: 746 PLKIHQVQHITQVAPPTPPPPPPIPAPLPPQAPPKPL 782


>gi|33356148 formin-like 1 [Homo sapiens]
          Length = 1100

 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 74/288 (25%), Positives = 117/288 (40%), Gaps = 58/288 (20%)

Query: 584 EKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKK-EICIAKHNEKIQQRT 642
           E   +    YL+R  L +  +   Q++A    +    + L + + +  + +H E++Q++ 
Sbjct: 349 EFTHLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQ- 407

Query: 643 RIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQRTLDR--LRTFKQRYPGQVILKST 699
                      V L  E+L D E    A +++ E+Q +  R  L T ++R+     + ++
Sbjct: 408 -----------VALLTERLRDAENESMAKIAELEKQLSQARKELETLRERFSESTAMGAS 456

Query: 700 RLRLAHARRKGAASPVLQEDHCDSLPSVLQVE-EKTEEVGEGRVKRGPSQTTEPQSL-VQ 757
           R R     +   A+P        + PS L+++ E+ EE G  R+ RGP      + L V 
Sbjct: 457 R-RPPEPEKAPPAAP--------TRPSALELKVEELEEKGLIRILRGPGDAVSIEILPVA 507

Query: 758 LEDTSLTQLEATSLPLSGVTSEL------------PPTISLPLLNNNLE----------- 794
           +   S        +P    + +L            PP   LP L +  E           
Sbjct: 508 VATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAAPPPPPPLPGLPSPQEAPPSAPPQAPP 567

Query: 795 ----PCSVTINPLPSPLPPTPPPPPPPP----PPPPPPPLPVAKDSGP 834
               P      PLP  LPP PPPPPPPP    P PPPPP P     GP
Sbjct: 568 LPGSPEPPPAPPLPGDLPPPPPPPPPPPGTDGPVPPPPPPPPPPPGGP 615


>gi|52485606 formin-like 2 [Homo sapiens]
          Length = 1092

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 90/355 (25%), Positives = 144/355 (40%), Gaps = 75/355 (21%)

Query: 495 KEICLE-QRKHALKEEMQSLRGGTE-AIARLDQLEADYYDLQLQLYEV--QFEILKCEEL 550
           KE+C E QR   L E  ++     +  +A +  +    + ++   + V  Q+E  K   L
Sbjct: 291 KEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTK---L 347

Query: 551 LLTAQLESIKRLISEKRDEVV--YYDTYESMEAMLEKEEMAASAYLQREELQK----LQQ 604
            L   L+ +K   S+K    +  Y D    + A+LE  E   +A  + EEL++    L +
Sbjct: 348 GLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAALERVEELEENISHLSE 407

Query: 605 KARQLE--ARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLH 662
           K +  E  A    V  +K  ++  KE+ + +   K        D     HT+   R+ + 
Sbjct: 408 KLQDTENEAMSKIVELEKQLMQRNKELDVVREIYK--------DANTQVHTL---RKMVK 456

Query: 663 DEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCD 722
           ++EE      + +RQ TL++ +  +    G + ++          +KG           D
Sbjct: 457 EKEE------AIQRQSTLEK-KIHELEKQGTIKIQ----------KKG-----------D 488

Query: 723 SLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPP 782
              ++L V      V  G +  G         +V       T   A+S PL      LPP
Sbjct: 489 GDIAILPV------VASGTLSMG-------SEVVAGNSVGPTMGAASSGPLPPPPPPLPP 535

Query: 783 TISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETL 837
           +   P    N         P+  P+PP PPPPPPPPPPPPPPP P       ET+
Sbjct: 536 SSDTPETVQN--------GPVTPPMPPPPPPPPPPPPPPPPPPPPPLPGPAAETV 582



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 32/139 (23%), Positives = 48/139 (34%), Gaps = 14/139 (10%)

Query: 730 VEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLL 789
           V+EK E +             E Q  ++++      +    +  SG  S     ++    
Sbjct: 455 VKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVASGTLSMGSEVVA---- 510

Query: 790 NNNLEPC--SVTINPLPSPLPPTPPPPPPPP--------PPPPPPPLPVAKDSGPETLEK 839
            N++ P   + +  PLP P PP PP    P         PP PPPP P      P     
Sbjct: 511 GNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPPPPPP 570

Query: 840 DLPRKEGNEKRIPKSASAP 858
             P      + +P    AP
Sbjct: 571 PPPLPGPAAETVPAPPLAP 589


>gi|158534059 formin binding protein 4 [Homo sapiens]
          Length = 1017

 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 53/187 (28%), Positives = 79/187 (42%), Gaps = 23/187 (12%)

Query: 731 EEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSL---PLSGVTSE---LPPTI 784
           EE+  +  E R +    QT + ++      T  ++    SL     SG  S    +P T 
Sbjct: 632 EEEESQAQENRDETLAKQTLKDKTGTDSNSTESSETSTGSLCKESFSGQVSSSSLMPLTP 691

Query: 785 SLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPV---------AKDSGPE 835
              LL +N+    V   PLP  +PP PPPPP  PPPPPPPP P           +D G E
Sbjct: 692 FWTLLQSNVP---VLQPPLPLEMPPPPPPPPESPPPPPPPPPPAEDGEIQEVEMEDEGSE 748

Query: 836 T-----LEKDLPRKEGNEKRIPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSP 890
                  E+D P K   +  +  S S+  + +  SS     ++K  + +  + +R  +  
Sbjct: 749 EPPAPGTEEDTPLKPSAQTTVVTSQSSVDSTISSSSSTKGIKRKATEISTAVVQRSATIG 808

Query: 891 MDEVLAS 897
              VL S
Sbjct: 809 SSPVLYS 815



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 16/26 (61%), Positives = 19/26 (73%)

Query: 802 PLPSPLPPTPPPPPPPPPPPPPPPLP 827
           P  + + P PPPPPPPPPPPP P +P
Sbjct: 898 PTATIIEPPPPPPPPPPPPPPAPKMP 923



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 29/71 (40%), Positives = 32/71 (45%), Gaps = 12/71 (16%)

Query: 796 CSVTINPLPSPLPP----------TPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKE 845
           CSV I      L P          T   PPPPPPPPPPPP P  K   PE  +K   RK+
Sbjct: 877 CSVPIGVTAPSLQPVQARGAVPTATIIEPPPPPPPPPPPPPPAPKMPPPEKTKKG--RKD 934

Query: 846 GNEKRIPKSAS 856
             +K   K  S
Sbjct: 935 KAKKSKTKMPS 945



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 26/70 (37%), Positives = 35/70 (50%), Gaps = 5/70 (7%)

Query: 770 SLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPPLPVA 829
           S+P+ GVT+   P++  P+      P +  I P P P PP PPPPP P  PPP       
Sbjct: 878 SVPI-GVTA---PSLQ-PVQARGAVPTATIIEPPPPPPPPPPPPPPAPKMPPPEKTKKGR 932

Query: 830 KDSGPETLEK 839
           KD   ++  K
Sbjct: 933 KDKAKKSKTK 942



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 24/74 (32%), Positives = 32/74 (43%)

Query: 766 LEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPP 825
           L A    +S     +P  ++ P L       +V    +  P PP PPPPPPPPP P  PP
Sbjct: 865 LAAAPAIMSYAECSVPIGVTAPSLQPVQARGAVPTATIIEPPPPPPPPPPPPPPAPKMPP 924

Query: 826 LPVAKDSGPETLEK 839
               K    +  +K
Sbjct: 925 PEKTKKGRKDKAKK 938


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 99/465 (21%), Positives = 203/465 (43%), Gaps = 50/465 (10%)

Query: 314 DDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLA 373
           D+ +     L ELR+KG EE  Q+ R+R   +  + +  E       L + E++      
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265

Query: 374 EATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRI---ESLQKEDADWQRKAH 430
           +   EL +       +  +L  L RQ+++   + +    +R+   + L+++  + +R+  
Sbjct: 266 QRQRELQE-------EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318

Query: 431 MAVLSIQDLTVKYFE-----ITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVS 485
                 Q+   +  E     +  + ++    ++R +Q++  +       +  E+ +  + 
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378

Query: 486 KETLQMMRAKEICLEQ---RKHALKEEMQSLRGGTEAIARLDQLEADYY---DLQLQLYE 539
           +E  Q+ R +++  EQ   R+  L+ E Q  R   + + R  QL  +     + + + +E
Sbjct: 379 REQ-QLRREQQLRREQQLRREQQLRREQQLRR--EQQLRREQQLRREQQLRREQEEERHE 435

Query: 540 VQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEK--EEMAASAYLQRE 597
            + E  + E+ L   Q E    L   KR+E       E  +  L++  EE     +L+ E
Sbjct: 436 QKHEQERREQRLKREQEERRDWL---KREEETERHEQERRKQQLKRDQEEERRERWLKLE 492

Query: 598 ELQKL-QQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQL 656
           E ++  QQ+ R+ + RR +   ++  L+ ++E       E++QQR R E + R     + 
Sbjct: 493 EEERREQQERREQQLRREQEERREQRLKRQEE------EERLQQRLRSEQQLRREQ--EE 544

Query: 657 KREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVL 716
           +RE+L   EE K      E++R   RL+  ++    Q++ +    R    +R+       
Sbjct: 545 RREQLLKREEEKRL----EQERREQRLKREQEERRDQLLKREEERRQQRLKRE------- 593

Query: 717 QEDHCDSLPSVLQVEE-KTEEVGEGRVKRGPSQTTEPQSLVQLED 760
           QE+  +      +VE  + EE  E R+KR   +    Q L++ E+
Sbjct: 594 QEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEE 638



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 82/381 (21%), Positives = 162/381 (42%), Gaps = 51/381 (13%)

Query: 325 ELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAY----SSLAEATTELY 380
           +LR++  EE  ++  +R QE   + +      +L    QL  E        L        
Sbjct: 350 QLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409

Query: 381 QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESL---QKEDADWQRKAHMAVLSIQ 437
           +  L+  + +R    LRR+Q +   E  +   RR + L   Q+E  DW ++         
Sbjct: 410 EQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREE------- 462

Query: 438 DLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEI 497
                  E     Q+    +++ DQ++  +  W    E   + Q    +   Q+ R +E 
Sbjct: 463 -------ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQ--ERREQQLRREQEE 513

Query: 498 CLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEE---LLLTA 554
             EQR    +EE            RL Q       L+ +  E + ++LK EE   L    
Sbjct: 514 RREQRLKRQEEE-----------ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQER 562

Query: 555 QLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKAR------- 607
           + + +KR   E+RD+++  +     + +  ++E      L+REE+++L+Q+ R       
Sbjct: 563 REQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622

Query: 608 ---QLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDE 664
              + E R+  + +++   R ++++   +   + Q+  R E+E R     +LKRE  H+E
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQ--RLKRE--HEE 678

Query: 665 EERKSAWVSQERQRTLDRLRT 685
           E R+     +E+++  +R+++
Sbjct: 679 ERREQELAEEEQEQARERIKS 699



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 91/369 (24%), Positives = 158/369 (42%), Gaps = 44/369 (11%)

Query: 332  EEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDMR 391
            EE  ++AR+RI+  + K +           +QLE EA +  ++  +   +   Q  R  +
Sbjct: 687  EEEQEQARERIKSRIPKWQ-----------WQLESEADARQSKVYSRPRKQEGQRRRQEQ 735

Query: 392  ELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAV------LSIQDLTVKYFE 445
            E    RR+      E +    ++ E  Q+ D  WQ +A          LS +    +  E
Sbjct: 736  EEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRE 795

Query: 446  ITAKAQKAVYDRMR-ADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKH 504
               +A++      R   +++  +       ER ++LQ+   +E LQ  R +   L++ + 
Sbjct: 796  RQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR-RERAQQLQEEED 854

Query: 505  ALKEEMQSLRGGTEAIARLDQ-----LEADYYDLQLQLYEVQF--EILKCEELLLTAQLE 557
             L+E+ +  R   +   R DQ     LE +    +  LY      E L+ E+ LL  + E
Sbjct: 855  GLQEDQERRRSQEQ---RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE 911

Query: 558  SIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKL-QQKARQLEARRGRV 616
             ++R   EKR         +  E    +EE      LQ+EE Q L +++ ++    R R 
Sbjct: 912  ELQREEREKRRR-------QEQERQYREEEQ-----LQQEEEQLLREEREKRRRQERERQ 959

Query: 617  SAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQER 676
              K   L+ K+E  + +  EK +++ R E +YR    +Q + E+L  EE  K      ER
Sbjct: 960  YRKDKKLQQKEEQLLGEEPEKRRRQER-EKKYREEEELQQEEEQLLREEREKRRRQEWER 1018

Query: 677  Q-RTLDRLR 684
            Q R  D L+
Sbjct: 1019 QYRKKDELQ 1027



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 83/380 (21%), Positives = 162/380 (42%), Gaps = 50/380 (13%)

Query: 312  ETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDE---- 367
            E +   ++ E   +L+++   + LQ     +QE  ++ ++ E   +    +QLE+E    
Sbjct: 826  EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 368  -----AYSSLAEATTELYQYLLQPFRDMR--ELAMLRRQQIKISMENDYLGPRRIESLQK 420
                 A  +L E   +  Q L +   +++  E    RRQ+ +     +    +  E L +
Sbjct: 886  RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLR 945

Query: 421  EDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKL 480
            E+ + +R+        +D  ++  E     ++    R +  +KK+ +       E +++ 
Sbjct: 946  EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREE------EELQQE 999

Query: 481  QYAVSKETLQMMRAKEICLEQRK--HALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +  + +E  +  R +E   + RK     +EE Q LR   E   RL + E  Y + +    
Sbjct: 1000 EEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK-RRLQERERQYREEE---- 1054

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                E+ + EE LL  + E+ +R               + +E    KEE      LQ+EE
Sbjct: 1055 ----ELQQEEEQLLGEERETRRR---------------QELERQYRKEEE-----LQQEE 1090

Query: 599  LQKLQQK-ARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLK 657
             Q L+++  ++    R R   ++  L+ ++E  + +  EK ++R  +E +YR    VQ +
Sbjct: 1091 EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREK-RRRQELERQYREEEEVQQE 1149

Query: 658  REKLHDEEERKSAWVSQERQ 677
             E+L  EE  K      ERQ
Sbjct: 1150 EEQLLREEPEKRRRQELERQ 1169



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 74/362 (20%), Positives = 146/362 (40%), Gaps = 43/362 (11%)

Query: 335  LQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDMRELA 394
            LQ   ++ Q+LL + +      E     + E E      E   +  + LL+  R+ R   
Sbjct: 895  LQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKR--- 951

Query: 395  MLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAV 454
              RRQ+ +     D    ++ E L  E+ + +R+        Q+   KY E   + Q+  
Sbjct: 952  --RRQERERQYRKDKKLQQKEEQLLGEEPEKRRR--------QEREKKYRE-EEELQQEE 1000

Query: 455  YDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQS-- 512
               +R +++K  +  W     + ++LQ    +   +    + +   +R++  +EE+Q   
Sbjct: 1001 EQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEE 1060

Query: 513  --LRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEV 570
              L G      R  +LE  Y          + E+ + EE LL  + E  +R   E++   
Sbjct: 1061 EQLLGEERETRRRQELERQY--------RKEEELQQEEEQLLREEPEKRRRQERERQCR- 1111

Query: 571  VYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEIC 630
                  E  E   E+E++      +  E ++ Q+  RQ          ++  LR + E  
Sbjct: 1112 ------EEEELQQEEEQLLR----EEREKRRRQELERQYREEEEVQQEEEQLLREEPE-- 1159

Query: 631  IAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQE---RQRTLDRLRTFK 687
              +  ++++++ R E+E +      L+ E+    +ER+  +  +E   RQ+   R R   
Sbjct: 1160 -KRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDED 1218

Query: 688  QR 689
            QR
Sbjct: 1219 QR 1220



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 81/391 (20%), Positives = 165/391 (42%), Gaps = 52/391 (13%)

Query: 307 QVLFTETDDPEEYYESLSELRQKGYEEVLQRARK--RIQELLDKHKNTESMVELLDLYQL 364
           Q L    +  E   + L   +Q+  E+ L+R  +  R+++ L +    E   +  +L + 
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQ--ELAEE 688

Query: 365 EDEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQK-EDA 423
           E E      ++    +Q+ L+   D R+  +  R             PR+ E  ++ ++ 
Sbjct: 689 EQEQARERIKSRIPKWQWQLESEADARQSKVYSR-------------PRKQEGQRRRQEQ 735

Query: 424 DWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYA 483
           + +R+   + L  Q+            ++A   +   +Q++     W A  +     Q  
Sbjct: 736 EEKRRRRESELQWQE-----------EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRL 784

Query: 484 VSKETLQMMRAKEICLEQRKHA----LKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYE 539
            ++  L+  R +++  E+R+      L EE +  +   +   R  +L+    + QLQ  E
Sbjct: 785 SARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844

Query: 540 VQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQ---R 596
              ++ + E+ L   Q    +R   ++RD+   +   E  E    +  + A   LQ   R
Sbjct: 845 RAQQLQEEEDGLQEDQER--RRSQEQRRDQKWRWQLEE--ERKRRRHTLYAKPALQEQLR 900

Query: 597 EELQKLQQKARQLE----ARRGRVSAKKSY-----LRNKKEICIAKHNEKIQQRTRIEDE 647
           +E Q LQ++  +L+     +R R   ++ Y     L+ ++E  + +  EK +++ R E +
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER-ERQ 959

Query: 648 YRTHHTVQLKREKLHDEEERKSAWVSQERQR 678
           YR    +Q K E+L  EE  K     QER++
Sbjct: 960 YRKDKKLQQKEEQLLGEEPEKRR--RQEREK 988



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 50/200 (25%), Positives = 88/200 (44%), Gaps = 15/200 (7%)

Query: 577 ESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNE 636
           E   A  + +E       Q E+ ++ + + RQLE   G+   +K   R ++E  +A+  E
Sbjct: 97  EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQK---RQEQERELAEGEE 153

Query: 637 KIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVIL 696
           + +++ R+E   R     +L R++  + +ER+     +E+ ++     T  + +P +  L
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQR-QEWQEREERRAEEEQLQSCKGHET--EEFPDEEQL 210

Query: 697 KSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPS---QTTEPQ 753
           +  R  L   RRKG      Q+   +    V Q EE+ E      V R      Q  EPQ
Sbjct: 211 R--RRELLELRRKGREEK--QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266

Query: 754 SL--VQLEDTSLTQLEATSL 771
               +Q E+  L +LE   L
Sbjct: 267 RQRELQEEEEQLRKLERQEL 286



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 80/399 (20%), Positives = 164/399 (41%), Gaps = 33/399 (8%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            + L  L  +  E   ++ R+R Q+  D+H   E  +E       E++  +   +  ++  
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQR-DRHFPEEEQLER------EEQKEAKRRDRKSQEE 1317

Query: 381  QYLLQPFRDMRELAMLRRQQI--KISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQD 438
            + LL+  R+ +     RRQ+   K   E   L  R  + L++++ D  RK     L  Q+
Sbjct: 1318 KQLLREEREEKR----RRQETDRKFREEEQLLQEREEQPLRRQERD--RKFREEELRHQE 1371

Query: 439  LTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEIC 498
               K+ E   +       R +  ++KF K       +  E+ Q    ++       +++ 
Sbjct: 1372 QGRKFLEEEQRL------RRQERERKFLKEEQQLRCQEREQ-QLRQDRDRKFREEEQQLS 1424

Query: 499  LEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQ--- 555
             ++R    +EE Q +R        L++ +    +   +  E +  + + EE  L  Q   
Sbjct: 1425 RQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERD 1484

Query: 556  ---LESIKRLISEKRDEVVYYDTYESMEA---MLEKEEMAASAYLQREELQKLQQKARQL 609
               LE  ++L  ++RD         S E     LE+E+       QR+ LQ+ QQ  RQ 
Sbjct: 1485 RKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQE 1544

Query: 610  EARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKS 669
              ++ R    + + R ++++   +  +++ ++ R + ++R       ++E+     E + 
Sbjct: 1545 RGQQRRQDRDRKF-REEEQLRQEREEQQLSRQER-DRKFRLEEQKVRRQEQERKFMEDEQ 1602

Query: 670  AWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                QE Q+ L + R  K R   Q++ +    +L    R
Sbjct: 1603 QLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641



 Score = 38.5 bits (88), Expect = 0.031
 Identities = 80/383 (20%), Positives = 156/383 (40%), Gaps = 30/383 (7%)

Query: 326 LRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQ 385
           L+++  E + QR ++   E L++ +  E  ++  +  +   +      E      Q L +
Sbjct: 590 LKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRR 649

Query: 386 PFRDMRELAMLRRQQ---IKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVK 442
             ++ RE  + R ++   ++  ++ ++   RR + L +E+   Q +A   + S       
Sbjct: 650 EQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE---QEQARERIKSRIPKWQW 706

Query: 443 YFEITAKA-QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQ 501
             E  A A Q  VY R R  + +  +        R E       +E     + +E   EQ
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE---EQ 763

Query: 502 RKHAL---KEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLES 558
           R+      + E +S RG     AR    E     L+ +  + + +    EE     + E 
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEE----EEKEQ 819

Query: 559 IKRLISEKRDEVVYYDTYESMEA-----MLEKEE--MAASAYLQREELQKLQQKAR-QLE 610
            +R   E+  E+ + +  E ++       L++EE  +      +R + Q+  QK R QLE
Sbjct: 820 RRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLE 879

Query: 611 ARRGR----VSAKKSYLRN-KKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEE 665
             R R    + AK +     +KE  + +  E+  QR   E   R     Q + E+   +E
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939

Query: 666 ERKSAWVSQERQRTLDRLRTFKQ 688
           E +     +E++R  +R R +++
Sbjct: 940 EEQLLREEREKRRRQERERQYRK 962



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 63/301 (20%), Positives = 122/301 (40%), Gaps = 22/301 (7%)

Query: 327  RQKGYEEVLQRARKRIQE---LLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            RQ+G +++ Q   ++ +E   LL + +  +   +  D   LE+E      E   +L    
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665

Query: 384  LQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKY 443
             + FR+  +L     +Q     E D       + L++++ + +       L  Q+L  K+
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKF 1725

Query: 444  FEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRK 503
             E     Q+   +++R  Q+++ K         +E+ Q    +E  Q+ R +     + +
Sbjct: 1726 REEEQLRQETEQEQLRR-QERYRKI--------LEEEQLRPEREEQQLRRQERDRKFREE 1776

Query: 504  HALKEEM--QSLRG--GTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
              L++E   Q LR           +QL  +  + QL+  +   +    EE L   QLE  
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL---QLEEQ 1833

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            ++ + ++RD        E   A  EK         Q EE ++ Q++ R+L     R   K
Sbjct: 1834 EQRLRQERDRQY---RAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQK 1890

Query: 620  K 620
            +
Sbjct: 1891 E 1891



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 73/367 (19%), Positives = 152/367 (41%), Gaps = 33/367 (8%)

Query: 327  RQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQP 386
            RQ   EE LQR +KR Q   D+ + ++        +Q E E  +++ +          + 
Sbjct: 1197 RQYREEEELQR-QKRKQRYRDEDQRSDLK------WQWEPEKENAVRDNKVYCKGRENEQ 1249

Query: 387  FRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEI 446
            FR + + + LR +Q +  +++  LG ++    ++E   WQ++             ++F  
Sbjct: 1250 FRQLED-SQLRDRQSQQDLQH-LLGEQQERDREQERRRWQQRD------------RHFPE 1295

Query: 447  TAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHA- 505
              + ++      +   +K  +       ER EK +    +ET +  R +E  L++R+   
Sbjct: 1296 EEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRR---RQETDRKFREEEQLLQEREEQP 1352

Query: 506  LKEEMQSLRGGTEAIARLDQLEADYYDLQ-LQLYEVQFEILKCEELLLTAQLESIKRLIS 564
            L+ + +  +   E +   +Q      + Q L+  E + + LK E+ L   + E   R   
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412

Query: 565  EK--RDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSY 622
            ++  R+E       E      E+E+       ++E  +K  ++ +QL   R R   ++  
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVR----RQERERKFLEEEQQLRQERHRKFREEEQ 1468

Query: 623  LRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQ-RTLD 681
            L  ++E       E+ ++    E + R     +  RE+    +E +  ++ +E+Q     
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 682  RLRTFKQ 688
            R R F Q
Sbjct: 1529 RQRKFLQ 1535


>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
          Length = 2115

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 115/558 (20%), Positives = 234/558 (41%), Gaps = 108/558 (19%)

Query: 326  LRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQ 385
            L ++G  + L+R       ++ + + ++ + E L L Q E  + S+ A   +   +  +Q
Sbjct: 1242 LEKEGESKELKRL------VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQ 1295

Query: 386  PFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFE 445
              R+  E   +  + ++  + +      R E L +E   WQ K      ++  L +++  
Sbjct: 1296 SLREEAEKQRVASENLRQELTSQ---AERAEELGQELKAWQEKFFQKEQALSTLQLEHTS 1352

Query: 446  ITAKAQ-----KAVYDRMRADQ--------KKFGKASWAAAAERMEKLQ----------- 481
              A        K +  +++A+Q        ++  ++  AA   R E L+           
Sbjct: 1353 TQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELIPL 1412

Query: 482  ---YAVSKETLQMMRAK------EICLEQRKHALKEEMQSLRGGTEAIAR------LDQL 526
                A  + T Q +RA+      ++ + ++ H L  E     G    + R      LDQ 
Sbjct: 1413 RQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQA 1472

Query: 527  EADYY--------DLQLQLYEVQFEILKCEELL--LTAQLESIKRLISEKRDEVVYYDTY 576
               Y         D + +L EVQ E       L  +TA+ E  K  + E+R    + +  
Sbjct: 1473 REKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQR--FQEER 1530

Query: 577  ESMEAMLEKEEMAASAYLQREELQKLQQKARQL----------EARRGRVSAKKSYLRNK 626
            + + A +E+ E+      QRE+ +++++ +++L          + +   V A+    + +
Sbjct: 1531 QKLTAQVEQLEV-----FQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQE 1585

Query: 627  KEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTF 686
             +   A+ NE +Q +   +++   H+ +Q+++ K H + +++     QE+ R+L++L+  
Sbjct: 1586 AQRLQAQLNE-LQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644

Query: 687  KQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPS--------VLQVEEKTEEVG 738
             +       L++   RL H  ++        E  C  L +        V   +++  ++G
Sbjct: 1645 NKE------LRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLG 1698

Query: 739  EGRVKRGPSQTTEPQSLVQLEDTSLTQLEAT---SLPLSGVTSELPPT----ISLPLLNN 791
            + +V     ++ EPQ+  QL D S+  L+ +     PLS +TS+LP T     S+P    
Sbjct: 1699 KFQVATDALKSREPQAKPQL-DLSIDSLDLSCEEGTPLS-ITSKLPRTQPDGTSVP---- 1752

Query: 792  NLEPCSVTINPLPSPLPP 809
              EP S    P+   LPP
Sbjct: 1753 -GEPAS----PISQRLPP 1765



 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 104/473 (21%), Positives = 203/473 (42%), Gaps = 51/473 (10%)

Query: 333 EVLQRARKRIQELLDKHKNT------ESMVELLDLYQLEDEAYSSLAEATTELYQY--LL 384
           E+LQ    +++E L + ++       E + ++L L  L+ EA ++LA   T+L     +L
Sbjct: 381 EILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEA-ATLAANNTQLQARVEML 439

Query: 385 QPFRDMRELAML--------RRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSI 436
           +  R  +E  +L         +QQ+  S+  D        S  KE+ +   +AH A L+ 
Sbjct: 440 ETERGQQEAKLLAERGHFEEEKQQLS-SLITDLQSSISNLSQAKEELEQASQAHGARLTA 498

Query: 437 QDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKE 496
           Q  ++     T  A     D+  A  K+  K   A  A+ +++ + A S+     +    
Sbjct: 499 QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQA-SQGLRHQVEQLS 557

Query: 497 ICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQL 556
             L+Q++  LKE  +      +  A+     A+  +  L+  +   + L+  E    A+L
Sbjct: 558 SSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKL 617

Query: 557 ESIKRLI---SEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARR 613
           E +++ +   +E RD      T    +A  EK E++       EELQ   + ARQ E   
Sbjct: 618 EILQQQLQVANEARDSAQTSVT----QAQREKAELSRKV----EELQACVETARQ-EQHE 668

Query: 614 GRVSAKKSYLRNKKEICIAKHNEKI-QQRTRIEDEYRT-HHTVQLKREKLHDEEERKSAW 671
            +    +  L+ + E   A   E++ Q++ +++++ +    ++++ +  L +EE+R++A 
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL-EEEKRRAAD 727

Query: 672 VSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKG-------------AASPVLQE 718
             +E+QR +  L+   +    Q   +   L    A RKG             A + VL+ 
Sbjct: 728 ALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRR 787

Query: 719 DHCDSLPSVLQVEEKTE----EVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
           +  +++ +    E + E    EV   R +   SQ  E Q     ++  +T  E
Sbjct: 788 ELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKE 840



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 103/515 (20%), Positives = 207/515 (40%), Gaps = 64/515 (12%)

Query: 305 LSQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQL 364
           +  +L T         + L++ R    E  L+ A  R + L +K      M + +D   L
Sbjct: 205 MGDILQTPQFQMRRLKKQLADERSNRDELELELAENR-KLLTEKDAQIAMMQQRIDRLAL 263

Query: 365 EDEAYSSLAEATTELYQYLLQPFRDMRELAMLR-----RQQIKISMENDYLGPRRIESLQ 419
            +E      +A + L    L+  RD  E   +R     +Q   +  E   +  R+I  L 
Sbjct: 264 LNEK-----QAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMD-RKINQLS 317

Query: 420 KEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWA-----AAA 474
           +E+ D   K       +Q L     E+T +  KA  + +    +   + S A        
Sbjct: 318 EENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLE 377

Query: 475 ERMEKLQYAVSKETLQMMRAKEICLEQR---------KHALKEEMQSL-RGGTEAIARLD 524
           E+ E LQ  +S+    + + ++   +++            LK+E  +L    T+  AR++
Sbjct: 378 EKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVE 437

Query: 525 QLEAD--YYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEV-----VYYDTYE 577
            LE +    + +L      FE  K +   L   L+S    +S+ ++E+      +     
Sbjct: 438 MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLT 497

Query: 578 SMEAMLEKEEMAASAYLQR--EELQKLQQKARQLEARRGRVSAKKSY----LRNKKEICI 631
           +  A L  E    +A +Q+  +EL  L+Q+A++ +A+  +   ++      LR++ E   
Sbjct: 498 AQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLS 557

Query: 632 AKHNEKIQQRTRI---EDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQ 688
           +   +K QQ   +   ++  R  H  QL        EER+++   +ER   L +L   ++
Sbjct: 558 SSLKQKEQQLKEVAEKQEATRQDHAQQLATA----AEEREAS--LRERDAALKQLEALEK 611

Query: 689 RYPGQVILKSTRLRLAHARRKGAASPVLQEDH--------CDSLPSVLQVEEKTEEVGEG 740
               ++ +   +L++A+  R  A + V Q            + L + ++   + +   + 
Sbjct: 612 EKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQA 671

Query: 741 RV-------KRGPSQTTEPQSLVQLEDTSLTQLEA 768
           +V       +    + TE + + Q +D    QL+A
Sbjct: 672 QVAELELQLRSEQQKATEKERVAQEKDQLQEQLQA 706



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 99/482 (20%), Positives = 192/482 (39%), Gaps = 58/482 (12%)

Query: 310  FTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLED--E 367
            + ++   E  Y ++ + +    +E  ++AR+ +QE  +K    ES  EL    Q  +  E
Sbjct: 817  YEDSQQEEAQYGAMFQEQLMTLKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAE 876

Query: 368  AYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQR 427
             +++LA A  ++ +  ++  +   +L+ L+ +    S E       R+E+L ++  + Q 
Sbjct: 877  LHANLARALQQVQEKEVRAQKLADDLSTLQEKMAATSKE-----VARLETLVRKAGEQQE 931

Query: 428  KAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKE 487
             A   +       VK        Q    +  +  Q    +A+  A     E++   + + 
Sbjct: 932  TASREL-------VKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERL 984

Query: 488  TLQMMRAKEICLEQRKHALKE--EMQSLRGGTEAIARLDQLEADYYDLQLQ--LYEVQFE 543
               +M ++    E+R    +E   +   RG  +A   L++      +++LQ  L E + E
Sbjct: 985  RAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVE 1044

Query: 544  ILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQ 603
                +E L  A  E        K  E+      E+ + + E EE+  +    +E+L K +
Sbjct: 1045 FATLQEALAHALTEK-----EGKDQELAKLRGLEAAQ-IKELEELRQTVKQLKEQLAKKE 1098

Query: 604  QKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHD 663
            ++       +   + +      K E   A+ + K++Q+ + + E        L+R     
Sbjct: 1099 KEHASGSGAQSEAAGRTEPTGPKLEALRAEVS-KLEQQCQKQQE----QADSLERSL--- 1150

Query: 664  EEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRL-----RLAHARRKGAASPVLQE 718
            E ER S     ER   L+ L+       GQ+  K+  L      LA A+R+ AA     +
Sbjct: 1151 EAERAS---RAERDSALETLQ-------GQLEEKAQELGHSQSALASAQRELAAFRTKVQ 1200

Query: 719  DHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTS 778
            DH            K E+  + +V RG  +     SL+   +  ++ L    L   G + 
Sbjct: 1201 DH-----------SKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESK 1249

Query: 779  EL 780
            EL
Sbjct: 1250 EL 1251


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 96/451 (21%), Positives = 192/451 (42%), Gaps = 35/451 (7%)

Query: 324  SELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            +E +++  +E  +R R+++Q+  +  +  ++ VEL    + E EA      A   L +  
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 384  LQPF---RDMRELAMLRRQQIKISMENDYLGPRRIES-LQKEDADWQRKAHMAVLSIQDL 439
            LQ     R +R+  + R +Q+++++E      R  E+ LQ + A +  K      S+Q+ 
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALET---AQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 440  TVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICL 499
             V   ++  +A++      RA Q+   + +   A   +E+ Q   ++     ++A+E+  
Sbjct: 1600 HVAVAQLREEAER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA- 1652

Query: 500  EQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
             Q+K   + E +  +   E  AR      +    Q +L E + E  K  +L   A+  + 
Sbjct: 1653 -QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE--KQRQL---AEGTAQ 1706

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            +RL +E+          E +    E E+      L  EEL +LQ++A     +R  + A+
Sbjct: 1707 QRLAAEQ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756

Query: 620  KSYLRNKKEICIA-KHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQ 677
             + +R + E+ +A K   + + R+  E   +       +  +L +E  R  A   + +RQ
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816

Query: 678  RTLDRLRTFKQRYPGQVILKSTRLRLAHARR-KGAASPVLQEDHCDSLPSVLQVEEKTEE 736
            R L      +QR   + +L      +  A R K  A   L+E   ++       E++  +
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876

Query: 737  VGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
                  +    +    + L QL   S ++LE
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELE 1907



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 141/652 (21%), Positives = 263/652 (40%), Gaps = 101/652 (15%)

Query: 152  QKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDA 211
            Q+ S  D   G A AA R A  EA+ + V+    +     ++E  E +K+     A + A
Sbjct: 2071 QEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 212  EQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLF 271
            +    A +L   AE+         Q  +A  +Q  + ++++E     F E+         
Sbjct: 2130 QAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQ----- 2180

Query: 272  GGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY-ESLSELRQKG 330
                   EQE+ TL  QL+                     ETD  +    E L  L+ + 
Sbjct: 2181 ---KAQVEQELTTLRLQLE---------------------ETDHQKNLLDEELQRLKAEA 2216

Query: 331  YEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDM 390
             E   QR++   +EL       E + +L    + E+ A     +  T+  ++L +    M
Sbjct: 2217 TEAARQRSQVE-EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKM 2273

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            +++A    +  ++S+        R+  L +ED   QR                    A A
Sbjct: 2274 KQVA---EEAARLSVAAQEAA--RLRQLAEEDLAQQR--------------------ALA 2308

Query: 451  QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
            +K + ++M+A Q+        A AE +++ +    ++  ++   KE   +Q    L EE 
Sbjct: 2309 EKMLKEKMQAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ----LAEET 2361

Query: 511  QSLRGGTEAIARLDQLE--ADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRD 568
            Q  +   EA  R  QLE  A+   L+L++ E+     + EE          +R    K+ 
Sbjct: 2362 QGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEE--------DAQRF--RKQA 2410

Query: 569  EVVYYDTYESMEAMLEKEEMAASAYLQREE----LQKLQQKARQLEARRGRVSAKKSYLR 624
            E +    + +  A  EK  +  +  +QR++     ++L++   +LE  + ++  +   L+
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470

Query: 625  NKKEICIAKHNEKIQQRTR-IEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRL 683
             K E       E++ Q T+ ++  + +     L+RE+  ++E+ K   + Q+      +L
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 684  RTFKQRYPGQVILKSTRL--RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEV--GE 739
            R  +QR   Q+  +  RL   +  ARR+   +        + L  + Q   + EE+   E
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590

Query: 740  GRVKRGPSQTTEPQ---SLVQLEDTSLTQLEAT-SLP-----LSGVTSELPP 782
             +  R   Q  E Q   +L   E+ + +Q+ AT +LP     L G  +E  P
Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2642



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 102/488 (20%), Positives = 205/488 (42%), Gaps = 58/488 (11%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            E  +  R+   EEV +R + +++E     +  E   E     QL  EA     +A  + +
Sbjct: 1998 EEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ--ESARQLQLAQEAAQKRLQAEEKAH 2054

Query: 381  QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLT 440
             + +Q      +  + + Q +   +  +    RR    + E+A  Q +   A        
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAA-------- 2105

Query: 441  VKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLE 500
                +   + ++A   +  A+++   +A   AAAE++ K      +E  +  +A++  L 
Sbjct: 2106 ----QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK---EAEQEAARRAQAEQAALR 2158

Query: 501  QRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV--QFEILKCEELLLTAQLES 558
            Q++ A  E  +  +   + + +  Q+E +   L+LQL E   Q  +L  E   L A+   
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218

Query: 559  IKRLISEKRDEV----VYYDTYESMEAMLEKEEMA--------ASAYLQREELQKLQQKA 606
              R  S+  +E+    V  +    ++A +E E  A           +LQ EE +K++Q A
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVA 2277

Query: 607  RQL--------EARRGRVSAKKSYLRNK--KEICIAKHNEKIQQRTRIEDE----YRTHH 652
             +         EA R R  A++   + +   E  + +  + +Q+ TR++ E     +   
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337

Query: 653  TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA 712
              Q +  +L +++E+ +  +++E Q     L   +QR   ++  ++ RL+L  A    A 
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSAEAERLKLRVAEMSRAQ 2396

Query: 713  SPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLP 772
            +   +ED         +  ++ EE+GE ++ R    T E  +LVQ  +    Q +  +  
Sbjct: 2397 ARA-EED-------AQRFRKQAEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447

Query: 773  LSGVTSEL 780
            L    +EL
Sbjct: 2448 LREAIAEL 2455



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 92/420 (21%), Positives = 155/420 (36%), Gaps = 61/420 (14%)

Query: 365  EDEAYSSLAEATTELYQYLLQPFRDMRE-LAMLRRQ-----QIKISMENDYLGPRRIESL 418
            EDEA+         L +   Q   D+ E LA LR+      + +  +  D L  RR   +
Sbjct: 1871 EDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR--QV 1923

Query: 419  QKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERME 478
            ++E    +     A     +L ++   I + A+  +  + +A+ +   +   AA  ER  
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983

Query: 479  KLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +      +   + + A+E    QRK AL EE++ L+   E   RL +        QLQL 
Sbjct: 1984 R---EAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQL- 2038

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                           AQ  + KRL +E                  EK    A    ++E 
Sbjct: 2039 ---------------AQEAAQKRLQAE------------------EKAHAFAVQQKEQEL 2065

Query: 599  LQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHT----- 653
             Q LQQ+   L+  RG   A +      +E  +    E  Q R ++E+  R   +     
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 654  -----VQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                  Q   EKL  E E+++A  +Q  Q  L + +                LR      
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 709  KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEA 768
            +   +  LQ +  D   ++L  E +  +       R  SQ  E    V+++   L++L+A
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/432 (18%), Positives = 174/432 (40%), Gaps = 37/432 (8%)

Query: 335  LQRARKRIQELLDKHKNT--ESMVELLDLYQLEDEA--YSSLAEATTELYQYLLQPFRDM 390
            ++R R+R+ +LL++ +    ++ V   +L QL  +   Y   A+      Q   +    +
Sbjct: 1174 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1233

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            + + +   Q ++  +  +      IE   ++  + QR A   + +I+D  ++   +T KA
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL--VTYKA 1291

Query: 451  Q-KAVYDRMRADQKKFGKAS----WAAAAERMEKLQYAVSK------ETLQMMRAKEICL 499
            Q + V    +  + + G  S    +        +L    S+      ETL+ M  +E   
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1351

Query: 500  EQRKHALKEEMQSLRGGTEAIARLD--------QLEADYYDLQLQLYEVQFEILKCEELL 551
            EQ++   +E +  +    E   +L         Q E +  +LQ ++ E   E+++ EE  
Sbjct: 1352 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVRREEAA 1408

Query: 552  LTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
            + AQ +  KR I E+  ++      E      + E    S     EE++ ++ +    E 
Sbjct: 1409 VDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
            +RG    +   LR + E   A+  +  ++  R+  + +     + + E       +  A 
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 672  VSQERQRTLDRLRTFK-------QRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSL 724
             ++E+QR L  L   +       +R     + ++ ++++A    + +A   LQ       
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586

Query: 725  PSVLQVEEKTEE 736
                Q+E   +E
Sbjct: 1587 EKTAQLERSLQE 1598


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 96/451 (21%), Positives = 192/451 (42%), Gaps = 35/451 (7%)

Query: 324  SELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            +E +++  +E  +R R+++Q+  +  +  ++ VEL    + E EA      A   L +  
Sbjct: 1489 AEAQKRQAQEEAERLRRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1546

Query: 384  LQPF---RDMRELAMLRRQQIKISMENDYLGPRRIES-LQKEDADWQRKAHMAVLSIQDL 439
            LQ     R +R+  + R +Q+++++E      R  E+ LQ + A +  K      S+Q+ 
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALET---AQRSAEAELQSKRASFAEKTAQLERSLQEE 1603

Query: 440  TVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICL 499
             V   ++  +A++      RA Q+   + +   A   +E+ Q   ++     ++A+E+  
Sbjct: 1604 HVAVAQLREEAER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA- 1656

Query: 500  EQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
             Q+K   + E +  +   E  AR      +    Q +L E + E  K  +L   A+  + 
Sbjct: 1657 -QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE--KQRQL---AEGTAQ 1710

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            +RL +E+          E +    E E+      L  EEL +LQ++A     +R  + A+
Sbjct: 1711 QRLAAEQ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1760

Query: 620  KSYLRNKKEICIA-KHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQ 677
             + +R + E+ +A K   + + R+  E   +       +  +L +E  R  A   + +RQ
Sbjct: 1761 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1820

Query: 678  RTLDRLRTFKQRYPGQVILKSTRLRLAHARR-KGAASPVLQEDHCDSLPSVLQVEEKTEE 736
            R L      +QR   + +L      +  A R K  A   L+E   ++       E++  +
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880

Query: 737  VGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
                  +    +    + L QL   S ++LE
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELE 1911



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 141/652 (21%), Positives = 263/652 (40%), Gaps = 101/652 (15%)

Query: 152  QKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDA 211
            Q+ S  D   G A AA R A  EA+ + V+    +     ++E  E +K+     A + A
Sbjct: 2075 QEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2133

Query: 212  EQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLF 271
            +    A +L   AE+         Q  +A  +Q  + ++++E     F E+         
Sbjct: 2134 QAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQ----- 2184

Query: 272  GGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY-ESLSELRQKG 330
                   EQE+ TL  QL+                     ETD  +    E L  L+ + 
Sbjct: 2185 ---KAQVEQELTTLRLQLE---------------------ETDHQKNLLDEELQRLKAEA 2220

Query: 331  YEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDM 390
             E   QR++   +EL       E + +L    + E+ A     +  T+  ++L +    M
Sbjct: 2221 TEAARQRSQVE-EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKM 2277

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            +++A    +  ++S+        R+  L +ED   QR                    A A
Sbjct: 2278 KQVA---EEAARLSVAAQEAA--RLRQLAEEDLAQQR--------------------ALA 2312

Query: 451  QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
            +K + ++M+A Q+        A AE +++ +    ++  ++   KE   +Q    L EE 
Sbjct: 2313 EKMLKEKMQAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ----LAEET 2365

Query: 511  QSLRGGTEAIARLDQLE--ADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRD 568
            Q  +   EA  R  QLE  A+   L+L++ E+     + EE          +R    K+ 
Sbjct: 2366 QGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEE--------DAQRF--RKQA 2414

Query: 569  EVVYYDTYESMEAMLEKEEMAASAYLQREE----LQKLQQKARQLEARRGRVSAKKSYLR 624
            E +    + +  A  EK  +  +  +QR++     ++L++   +LE  + ++  +   L+
Sbjct: 2415 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2474

Query: 625  NKKEICIAKHNEKIQQRTR-IEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRL 683
             K E       E++ Q T+ ++  + +     L+RE+  ++E+ K   + Q+      +L
Sbjct: 2475 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2534

Query: 684  RTFKQRYPGQVILKSTRL--RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEV--GE 739
            R  +QR   Q+  +  RL   +  ARR+   +        + L  + Q   + EE+   E
Sbjct: 2535 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2594

Query: 740  GRVKRGPSQTTEPQ---SLVQLEDTSLTQLEAT-SLP-----LSGVTSELPP 782
             +  R   Q  E Q   +L   E+ + +Q+ AT +LP     L G  +E  P
Sbjct: 2595 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2646



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 102/488 (20%), Positives = 205/488 (42%), Gaps = 58/488 (11%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            E  +  R+   EEV +R + +++E     +  E   E     QL  EA     +A  + +
Sbjct: 2002 EEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ--ESARQLQLAQEAAQKRLQAEEKAH 2058

Query: 381  QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLT 440
             + +Q      +  + + Q +   +  +    RR    + E+A  Q +   A        
Sbjct: 2059 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAA-------- 2109

Query: 441  VKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLE 500
                +   + ++A   +  A+++   +A   AAAE++ K      +E  +  +A++  L 
Sbjct: 2110 ----QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK---EAEQEAARRAQAEQAALR 2162

Query: 501  QRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV--QFEILKCEELLLTAQLES 558
            Q++ A  E  +  +   + + +  Q+E +   L+LQL E   Q  +L  E   L A+   
Sbjct: 2163 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2222

Query: 559  IKRLISEKRDEV----VYYDTYESMEAMLEKEEMA--------ASAYLQREELQKLQQKA 606
              R  S+  +E+    V  +    ++A +E E  A           +LQ EE +K++Q A
Sbjct: 2223 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVA 2281

Query: 607  RQL--------EARRGRVSAKKSYLRNK--KEICIAKHNEKIQQRTRIEDE----YRTHH 652
             +         EA R R  A++   + +   E  + +  + +Q+ TR++ E     +   
Sbjct: 2282 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2341

Query: 653  TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA 712
              Q +  +L +++E+ +  +++E Q     L   +QR   ++  ++ RL+L  A    A 
Sbjct: 2342 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSAEAERLKLRVAEMSRAQ 2400

Query: 713  SPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLP 772
            +   +ED         +  ++ EE+GE ++ R    T E  +LVQ  +    Q +  +  
Sbjct: 2401 ARA-EED-------AQRFRKQAEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2451

Query: 773  LSGVTSEL 780
            L    +EL
Sbjct: 2452 LREAIAEL 2459



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 92/420 (21%), Positives = 155/420 (36%), Gaps = 61/420 (14%)

Query: 365  EDEAYSSLAEATTELYQYLLQPFRDMRE-LAMLRRQ-----QIKISMENDYLGPRRIESL 418
            EDEA+         L +   Q   D+ E LA LR+      + +  +  D L  RR   +
Sbjct: 1875 EDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR--QV 1927

Query: 419  QKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERME 478
            ++E    +     A     +L ++   I + A+  +  + +A+ +   +   AA  ER  
Sbjct: 1928 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1987

Query: 479  KLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +      +   + + A+E    QRK AL EE++ L+   E   RL +        QLQL 
Sbjct: 1988 R---EAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQL- 2042

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                           AQ  + KRL +E                  EK    A    ++E 
Sbjct: 2043 ---------------AQEAAQKRLQAE------------------EKAHAFAVQQKEQEL 2069

Query: 599  LQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHT----- 653
             Q LQQ+   L+  RG   A +      +E  +    E  Q R ++E+  R   +     
Sbjct: 2070 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2129

Query: 654  -----VQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                  Q   EKL  E E+++A  +Q  Q  L + +                LR      
Sbjct: 2130 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2189

Query: 709  KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEA 768
            +   +  LQ +  D   ++L  E +  +       R  SQ  E    V+++   L++L+A
Sbjct: 2190 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2249



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/432 (18%), Positives = 174/432 (40%), Gaps = 37/432 (8%)

Query: 335  LQRARKRIQELLDKHKNT--ESMVELLDLYQLEDEA--YSSLAEATTELYQYLLQPFRDM 390
            ++R R+R+ +LL++ +    ++ V   +L QL  +   Y   A+      Q   +    +
Sbjct: 1178 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1237

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            + + +   Q ++  +  +      IE   ++  + QR A   + +I+D  ++   +T KA
Sbjct: 1238 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL--VTYKA 1295

Query: 451  Q-KAVYDRMRADQKKFGKAS----WAAAAERMEKLQYAVSK------ETLQMMRAKEICL 499
            Q + V    +  + + G  S    +        +L    S+      ETL+ M  +E   
Sbjct: 1296 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1355

Query: 500  EQRKHALKEEMQSLRGGTEAIARLD--------QLEADYYDLQLQLYEVQFEILKCEELL 551
            EQ++   +E +  +    E   +L         Q E +  +LQ ++ E   E+++ EE  
Sbjct: 1356 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVRREEAA 1412

Query: 552  LTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
            + AQ +  KR I E+  ++      E      + E    S     EE++ ++ +    E 
Sbjct: 1413 VDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1470

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
            +RG    +   LR + E   A+  +  ++  R+  + +     + + E       +  A 
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530

Query: 672  VSQERQRTLDRLRTFK-------QRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSL 724
             ++E+QR L  L   +       +R     + ++ ++++A    + +A   LQ       
Sbjct: 1531 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1590

Query: 725  PSVLQVEEKTEE 736
                Q+E   +E
Sbjct: 1591 EKTAQLERSLQE 1602


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 96/451 (21%), Positives = 192/451 (42%), Gaps = 35/451 (7%)

Query: 324  SELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            +E +++  +E  +R R+++Q+  +  +  ++ VEL    + E EA      A   L +  
Sbjct: 1485 AEAQKRQAQEEAERLRRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542

Query: 384  LQPF---RDMRELAMLRRQQIKISMENDYLGPRRIES-LQKEDADWQRKAHMAVLSIQDL 439
            LQ     R +R+  + R +Q+++++E      R  E+ LQ + A +  K      S+Q+ 
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALET---AQRSAEAELQSKRASFAEKTAQLERSLQEE 1599

Query: 440  TVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICL 499
             V   ++  +A++      RA Q+   + +   A   +E+ Q   ++     ++A+E+  
Sbjct: 1600 HVAVAQLREEAER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA- 1652

Query: 500  EQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
             Q+K   + E +  +   E  AR      +    Q +L E + E  K  +L   A+  + 
Sbjct: 1653 -QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE--KQRQL---AEGTAQ 1706

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            +RL +E+          E +    E E+      L  EEL +LQ++A     +R  + A+
Sbjct: 1707 QRLAAEQ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1756

Query: 620  KSYLRNKKEICIA-KHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQ 677
             + +R + E+ +A K   + + R+  E   +       +  +L +E  R  A   + +RQ
Sbjct: 1757 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1816

Query: 678  RTLDRLRTFKQRYPGQVILKSTRLRLAHARR-KGAASPVLQEDHCDSLPSVLQVEEKTEE 736
            R L      +QR   + +L      +  A R K  A   L+E   ++       E++  +
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876

Query: 737  VGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
                  +    +    + L QL   S ++LE
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELE 1907



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 141/652 (21%), Positives = 263/652 (40%), Gaps = 101/652 (15%)

Query: 152  QKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDA 211
            Q+ S  D   G A AA R A  EA+ + V+    +     ++E  E +K+     A + A
Sbjct: 2071 QEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2129

Query: 212  EQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLF 271
            +    A +L   AE+         Q  +A  +Q  + ++++E     F E+         
Sbjct: 2130 QAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQ----- 2180

Query: 272  GGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY-ESLSELRQKG 330
                   EQE+ TL  QL+                     ETD  +    E L  L+ + 
Sbjct: 2181 ---KAQVEQELTTLRLQLE---------------------ETDHQKNLLDEELQRLKAEA 2216

Query: 331  YEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDM 390
             E   QR++   +EL       E + +L    + E+ A     +  T+  ++L +    M
Sbjct: 2217 TEAARQRSQVE-EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKM 2273

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            +++A    +  ++S+        R+  L +ED   QR                    A A
Sbjct: 2274 KQVA---EEAARLSVAAQEAA--RLRQLAEEDLAQQR--------------------ALA 2308

Query: 451  QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
            +K + ++M+A Q+        A AE +++ +    ++  ++   KE   +Q    L EE 
Sbjct: 2309 EKMLKEKMQAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ----LAEET 2361

Query: 511  QSLRGGTEAIARLDQLE--ADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRD 568
            Q  +   EA  R  QLE  A+   L+L++ E+     + EE          +R    K+ 
Sbjct: 2362 QGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEE--------DAQRF--RKQA 2410

Query: 569  EVVYYDTYESMEAMLEKEEMAASAYLQREE----LQKLQQKARQLEARRGRVSAKKSYLR 624
            E +    + +  A  EK  +  +  +QR++     ++L++   +LE  + ++  +   L+
Sbjct: 2411 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2470

Query: 625  NKKEICIAKHNEKIQQRTR-IEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRL 683
             K E       E++ Q T+ ++  + +     L+RE+  ++E+ K   + Q+      +L
Sbjct: 2471 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2530

Query: 684  RTFKQRYPGQVILKSTRL--RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEV--GE 739
            R  +QR   Q+  +  RL   +  ARR+   +        + L  + Q   + EE+   E
Sbjct: 2531 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2590

Query: 740  GRVKRGPSQTTEPQ---SLVQLEDTSLTQLEAT-SLP-----LSGVTSELPP 782
             +  R   Q  E Q   +L   E+ + +Q+ AT +LP     L G  +E  P
Sbjct: 2591 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2642



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 102/488 (20%), Positives = 205/488 (42%), Gaps = 58/488 (11%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            E  +  R+   EEV +R + +++E     +  E   E     QL  EA     +A  + +
Sbjct: 1998 EEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ--ESARQLQLAQEAAQKRLQAEEKAH 2054

Query: 381  QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLT 440
             + +Q      +  + + Q +   +  +    RR    + E+A  Q +   A        
Sbjct: 2055 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAA-------- 2105

Query: 441  VKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLE 500
                +   + ++A   +  A+++   +A   AAAE++ K      +E  +  +A++  L 
Sbjct: 2106 ----QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK---EAEQEAARRAQAEQAALR 2158

Query: 501  QRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV--QFEILKCEELLLTAQLES 558
            Q++ A  E  +  +   + + +  Q+E +   L+LQL E   Q  +L  E   L A+   
Sbjct: 2159 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2218

Query: 559  IKRLISEKRDEV----VYYDTYESMEAMLEKEEMA--------ASAYLQREELQKLQQKA 606
              R  S+  +E+    V  +    ++A +E E  A           +LQ EE +K++Q A
Sbjct: 2219 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVA 2277

Query: 607  RQL--------EARRGRVSAKKSYLRNK--KEICIAKHNEKIQQRTRIEDE----YRTHH 652
             +         EA R R  A++   + +   E  + +  + +Q+ TR++ E     +   
Sbjct: 2278 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2337

Query: 653  TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA 712
              Q +  +L +++E+ +  +++E Q     L   +QR   ++  ++ RL+L  A    A 
Sbjct: 2338 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSAEAERLKLRVAEMSRAQ 2396

Query: 713  SPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLP 772
            +   +ED         +  ++ EE+GE ++ R    T E  +LVQ  +    Q +  +  
Sbjct: 2397 ARA-EED-------AQRFRKQAEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2447

Query: 773  LSGVTSEL 780
            L    +EL
Sbjct: 2448 LREAIAEL 2455



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 92/420 (21%), Positives = 155/420 (36%), Gaps = 61/420 (14%)

Query: 365  EDEAYSSLAEATTELYQYLLQPFRDMRE-LAMLRRQ-----QIKISMENDYLGPRRIESL 418
            EDEA+         L +   Q   D+ E LA LR+      + +  +  D L  RR   +
Sbjct: 1871 EDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR--QV 1923

Query: 419  QKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERME 478
            ++E    +     A     +L ++   I + A+  +  + +A+ +   +   AA  ER  
Sbjct: 1924 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1983

Query: 479  KLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +      +   + + A+E    QRK AL EE++ L+   E   RL +        QLQL 
Sbjct: 1984 R---EAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQL- 2038

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                           AQ  + KRL +E                  EK    A    ++E 
Sbjct: 2039 ---------------AQEAAQKRLQAE------------------EKAHAFAVQQKEQEL 2065

Query: 599  LQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHT----- 653
             Q LQQ+   L+  RG   A +      +E  +    E  Q R ++E+  R   +     
Sbjct: 2066 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2125

Query: 654  -----VQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                  Q   EKL  E E+++A  +Q  Q  L + +                LR      
Sbjct: 2126 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2185

Query: 709  KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEA 768
            +   +  LQ +  D   ++L  E +  +       R  SQ  E    V+++   L++L+A
Sbjct: 2186 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2245



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/432 (18%), Positives = 174/432 (40%), Gaps = 37/432 (8%)

Query: 335  LQRARKRIQELLDKHKNT--ESMVELLDLYQLEDEA--YSSLAEATTELYQYLLQPFRDM 390
            ++R R+R+ +LL++ +    ++ V   +L QL  +   Y   A+      Q   +    +
Sbjct: 1174 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1233

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            + + +   Q ++  +  +      IE   ++  + QR A   + +I+D  ++   +T KA
Sbjct: 1234 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL--VTYKA 1291

Query: 451  Q-KAVYDRMRADQKKFGKAS----WAAAAERMEKLQYAVSK------ETLQMMRAKEICL 499
            Q + V    +  + + G  S    +        +L    S+      ETL+ M  +E   
Sbjct: 1292 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1351

Query: 500  EQRKHALKEEMQSLRGGTEAIARLD--------QLEADYYDLQLQLYEVQFEILKCEELL 551
            EQ++   +E +  +    E   +L         Q E +  +LQ ++ E   E+++ EE  
Sbjct: 1352 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVRREEAA 1408

Query: 552  LTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
            + AQ +  KR I E+  ++      E      + E    S     EE++ ++ +    E 
Sbjct: 1409 VDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1466

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
            +RG    +   LR + E   A+  +  ++  R+  + +     + + E       +  A 
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526

Query: 672  VSQERQRTLDRLRTFK-------QRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSL 724
             ++E+QR L  L   +       +R     + ++ ++++A    + +A   LQ       
Sbjct: 1527 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1586

Query: 725  PSVLQVEEKTEE 736
                Q+E   +E
Sbjct: 1587 EKTAQLERSLQE 1598


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 96/451 (21%), Positives = 192/451 (42%), Gaps = 35/451 (7%)

Query: 324  SELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            +E +++  +E  +R R+++Q+  +  +  ++ VEL    + E EA      A   L +  
Sbjct: 1453 AEAQKRQAQEEAERLRRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510

Query: 384  LQPF---RDMRELAMLRRQQIKISMENDYLGPRRIES-LQKEDADWQRKAHMAVLSIQDL 439
            LQ     R +R+  + R +Q+++++E      R  E+ LQ + A +  K      S+Q+ 
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALET---AQRSAEAELQSKRASFAEKTAQLERSLQEE 1567

Query: 440  TVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICL 499
             V   ++  +A++      RA Q+   + +   A   +E+ Q   ++     ++A+E+  
Sbjct: 1568 HVAVAQLREEAER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA- 1620

Query: 500  EQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
             Q+K   + E +  +   E  AR      +    Q +L E + E  K  +L   A+  + 
Sbjct: 1621 -QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE--KQRQL---AEGTAQ 1674

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            +RL +E+          E +    E E+      L  EEL +LQ++A     +R  + A+
Sbjct: 1675 QRLAAEQ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1724

Query: 620  KSYLRNKKEICIA-KHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQ 677
             + +R + E+ +A K   + + R+  E   +       +  +L +E  R  A   + +RQ
Sbjct: 1725 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1784

Query: 678  RTLDRLRTFKQRYPGQVILKSTRLRLAHARR-KGAASPVLQEDHCDSLPSVLQVEEKTEE 736
            R L      +QR   + +L      +  A R K  A   L+E   ++       E++  +
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844

Query: 737  VGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
                  +    +    + L QL   S ++LE
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELE 1875



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 141/652 (21%), Positives = 263/652 (40%), Gaps = 101/652 (15%)

Query: 152  QKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDA 211
            Q+ S  D   G A AA R A  EA+ + V+    +     ++E  E +K+     A + A
Sbjct: 2039 QEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2097

Query: 212  EQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLF 271
            +    A +L   AE+         Q  +A  +Q  + ++++E     F E+         
Sbjct: 2098 QAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQ----- 2148

Query: 272  GGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY-ESLSELRQKG 330
                   EQE+ TL  QL+                     ETD  +    E L  L+ + 
Sbjct: 2149 ---KAQVEQELTTLRLQLE---------------------ETDHQKNLLDEELQRLKAEA 2184

Query: 331  YEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDM 390
             E   QR++   +EL       E + +L    + E+ A     +  T+  ++L +    M
Sbjct: 2185 TEAARQRSQVE-EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKM 2241

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            +++A    +  ++S+        R+  L +ED   QR                    A A
Sbjct: 2242 KQVA---EEAARLSVAAQEAA--RLRQLAEEDLAQQR--------------------ALA 2276

Query: 451  QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
            +K + ++M+A Q+        A AE +++ +    ++  ++   KE   +Q    L EE 
Sbjct: 2277 EKMLKEKMQAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ----LAEET 2329

Query: 511  QSLRGGTEAIARLDQLE--ADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRD 568
            Q  +   EA  R  QLE  A+   L+L++ E+     + EE          +R    K+ 
Sbjct: 2330 QGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEE--------DAQRF--RKQA 2378

Query: 569  EVVYYDTYESMEAMLEKEEMAASAYLQREE----LQKLQQKARQLEARRGRVSAKKSYLR 624
            E +    + +  A  EK  +  +  +QR++     ++L++   +LE  + ++  +   L+
Sbjct: 2379 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2438

Query: 625  NKKEICIAKHNEKIQQRTR-IEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRL 683
             K E       E++ Q T+ ++  + +     L+RE+  ++E+ K   + Q+      +L
Sbjct: 2439 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2498

Query: 684  RTFKQRYPGQVILKSTRL--RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEV--GE 739
            R  +QR   Q+  +  RL   +  ARR+   +        + L  + Q   + EE+   E
Sbjct: 2499 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2558

Query: 740  GRVKRGPSQTTEPQ---SLVQLEDTSLTQLEAT-SLP-----LSGVTSELPP 782
             +  R   Q  E Q   +L   E+ + +Q+ AT +LP     L G  +E  P
Sbjct: 2559 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2610



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 102/488 (20%), Positives = 205/488 (42%), Gaps = 58/488 (11%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            E  +  R+   EEV +R + +++E     +  E   E     QL  EA     +A  + +
Sbjct: 1966 EEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ--ESARQLQLAQEAAQKRLQAEEKAH 2022

Query: 381  QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLT 440
             + +Q      +  + + Q +   +  +    RR    + E+A  Q +   A        
Sbjct: 2023 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAA-------- 2073

Query: 441  VKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLE 500
                +   + ++A   +  A+++   +A   AAAE++ K      +E  +  +A++  L 
Sbjct: 2074 ----QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK---EAEQEAARRAQAEQAALR 2126

Query: 501  QRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV--QFEILKCEELLLTAQLES 558
            Q++ A  E  +  +   + + +  Q+E +   L+LQL E   Q  +L  E   L A+   
Sbjct: 2127 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2186

Query: 559  IKRLISEKRDEV----VYYDTYESMEAMLEKEEMA--------ASAYLQREELQKLQQKA 606
              R  S+  +E+    V  +    ++A +E E  A           +LQ EE +K++Q A
Sbjct: 2187 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVA 2245

Query: 607  RQL--------EARRGRVSAKKSYLRNK--KEICIAKHNEKIQQRTRIEDE----YRTHH 652
             +         EA R R  A++   + +   E  + +  + +Q+ TR++ E     +   
Sbjct: 2246 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2305

Query: 653  TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA 712
              Q +  +L +++E+ +  +++E Q     L   +QR   ++  ++ RL+L  A    A 
Sbjct: 2306 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSAEAERLKLRVAEMSRAQ 2364

Query: 713  SPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLP 772
            +   +ED         +  ++ EE+GE ++ R    T E  +LVQ  +    Q +  +  
Sbjct: 2365 ARA-EED-------AQRFRKQAEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2415

Query: 773  LSGVTSEL 780
            L    +EL
Sbjct: 2416 LREAIAEL 2423



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 92/420 (21%), Positives = 155/420 (36%), Gaps = 61/420 (14%)

Query: 365  EDEAYSSLAEATTELYQYLLQPFRDMRE-LAMLRRQ-----QIKISMENDYLGPRRIESL 418
            EDEA+         L +   Q   D+ E LA LR+      + +  +  D L  RR   +
Sbjct: 1839 EDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR--QV 1891

Query: 419  QKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERME 478
            ++E    +     A     +L ++   I + A+  +  + +A+ +   +   AA  ER  
Sbjct: 1892 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1951

Query: 479  KLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +      +   + + A+E    QRK AL EE++ L+   E   RL +        QLQL 
Sbjct: 1952 R---EAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQL- 2006

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                           AQ  + KRL +E                  EK    A    ++E 
Sbjct: 2007 ---------------AQEAAQKRLQAE------------------EKAHAFAVQQKEQEL 2033

Query: 599  LQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHT----- 653
             Q LQQ+   L+  RG   A +      +E  +    E  Q R ++E+  R   +     
Sbjct: 2034 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2093

Query: 654  -----VQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                  Q   EKL  E E+++A  +Q  Q  L + +                LR      
Sbjct: 2094 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2153

Query: 709  KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEA 768
            +   +  LQ +  D   ++L  E +  +       R  SQ  E    V+++   L++L+A
Sbjct: 2154 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2213



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/432 (18%), Positives = 174/432 (40%), Gaps = 37/432 (8%)

Query: 335  LQRARKRIQELLDKHKNT--ESMVELLDLYQLEDEA--YSSLAEATTELYQYLLQPFRDM 390
            ++R R+R+ +LL++ +    ++ V   +L QL  +   Y   A+      Q   +    +
Sbjct: 1142 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1201

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            + + +   Q ++  +  +      IE   ++  + QR A   + +I+D  ++   +T KA
Sbjct: 1202 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL--VTYKA 1259

Query: 451  Q-KAVYDRMRADQKKFGKAS----WAAAAERMEKLQYAVSK------ETLQMMRAKEICL 499
            Q + V    +  + + G  S    +        +L    S+      ETL+ M  +E   
Sbjct: 1260 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1319

Query: 500  EQRKHALKEEMQSLRGGTEAIARLD--------QLEADYYDLQLQLYEVQFEILKCEELL 551
            EQ++   +E +  +    E   +L         Q E +  +LQ ++ E   E+++ EE  
Sbjct: 1320 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVRREEAA 1376

Query: 552  LTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
            + AQ +  KR I E+  ++      E      + E    S     EE++ ++ +    E 
Sbjct: 1377 VDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1434

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
            +RG    +   LR + E   A+  +  ++  R+  + +     + + E       +  A 
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494

Query: 672  VSQERQRTLDRLRTFK-------QRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSL 724
             ++E+QR L  L   +       +R     + ++ ++++A    + +A   LQ       
Sbjct: 1495 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1554

Query: 725  PSVLQVEEKTEE 736
                Q+E   +E
Sbjct: 1555 EKTAQLERSLQE 1566


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 96/451 (21%), Positives = 192/451 (42%), Gaps = 35/451 (7%)

Query: 324  SELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            +E +++  +E  +R R+++Q+  +  +  ++ VEL    + E EA      A   L +  
Sbjct: 1622 AEAQKRQAQEEAERLRRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679

Query: 384  LQPF---RDMRELAMLRRQQIKISMENDYLGPRRIES-LQKEDADWQRKAHMAVLSIQDL 439
            LQ     R +R+  + R +Q+++++E      R  E+ LQ + A +  K      S+Q+ 
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALET---AQRSAEAELQSKRASFAEKTAQLERSLQEE 1736

Query: 440  TVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICL 499
             V   ++  +A++      RA Q+   + +   A   +E+ Q   ++     ++A+E+  
Sbjct: 1737 HVAVAQLREEAER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA- 1789

Query: 500  EQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
             Q+K   + E +  +   E  AR      +    Q +L E + E  K  +L   A+  + 
Sbjct: 1790 -QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE--KQRQL---AEGTAQ 1843

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            +RL +E+          E +    E E+      L  EEL +LQ++A     +R  + A+
Sbjct: 1844 QRLAAEQ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893

Query: 620  KSYLRNKKEICIA-KHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQ 677
             + +R + E+ +A K   + + R+  E   +       +  +L +E  R  A   + +RQ
Sbjct: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1953

Query: 678  RTLDRLRTFKQRYPGQVILKSTRLRLAHARR-KGAASPVLQEDHCDSLPSVLQVEEKTEE 736
            R L      +QR   + +L      +  A R K  A   L+E   ++       E++  +
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013

Query: 737  VGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
                  +    +    + L QL   S ++LE
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELE 2044



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 141/652 (21%), Positives = 263/652 (40%), Gaps = 101/652 (15%)

Query: 152  QKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDA 211
            Q+ S  D   G A AA R A  EA+ + V+    +     ++E  E +K+     A + A
Sbjct: 2208 QEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2266

Query: 212  EQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLF 271
            +    A +L   AE+         Q  +A  +Q  + ++++E     F E+         
Sbjct: 2267 QAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQ----- 2317

Query: 272  GGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY-ESLSELRQKG 330
                   EQE+ TL  QL+                     ETD  +    E L  L+ + 
Sbjct: 2318 ---KAQVEQELTTLRLQLE---------------------ETDHQKNLLDEELQRLKAEA 2353

Query: 331  YEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDM 390
             E   QR++   +EL       E + +L    + E+ A     +  T+  ++L +    M
Sbjct: 2354 TEAARQRSQVE-EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKM 2410

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            +++A    +  ++S+        R+  L +ED   QR                    A A
Sbjct: 2411 KQVA---EEAARLSVAAQEAA--RLRQLAEEDLAQQR--------------------ALA 2445

Query: 451  QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
            +K + ++M+A Q+        A AE +++ +    ++  ++   KE   +Q    L EE 
Sbjct: 2446 EKMLKEKMQAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ----LAEET 2498

Query: 511  QSLRGGTEAIARLDQLE--ADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRD 568
            Q  +   EA  R  QLE  A+   L+L++ E+     + EE          +R    K+ 
Sbjct: 2499 QGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEE--------DAQRF--RKQA 2547

Query: 569  EVVYYDTYESMEAMLEKEEMAASAYLQREE----LQKLQQKARQLEARRGRVSAKKSYLR 624
            E +    + +  A  EK  +  +  +QR++     ++L++   +LE  + ++  +   L+
Sbjct: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2607

Query: 625  NKKEICIAKHNEKIQQRTR-IEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRL 683
             K E       E++ Q T+ ++  + +     L+RE+  ++E+ K   + Q+      +L
Sbjct: 2608 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2667

Query: 684  RTFKQRYPGQVILKSTRL--RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEV--GE 739
            R  +QR   Q+  +  RL   +  ARR+   +        + L  + Q   + EE+   E
Sbjct: 2668 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2727

Query: 740  GRVKRGPSQTTEPQ---SLVQLEDTSLTQLEAT-SLP-----LSGVTSELPP 782
             +  R   Q  E Q   +L   E+ + +Q+ AT +LP     L G  +E  P
Sbjct: 2728 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2779



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 102/488 (20%), Positives = 205/488 (42%), Gaps = 58/488 (11%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            E  +  R+   EEV +R + +++E     +  E   E     QL  EA     +A  + +
Sbjct: 2135 EEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ--ESARQLQLAQEAAQKRLQAEEKAH 2191

Query: 381  QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLT 440
             + +Q      +  + + Q +   +  +    RR    + E+A  Q +   A        
Sbjct: 2192 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAA-------- 2242

Query: 441  VKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLE 500
                +   + ++A   +  A+++   +A   AAAE++ K      +E  +  +A++  L 
Sbjct: 2243 ----QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK---EAEQEAARRAQAEQAALR 2295

Query: 501  QRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV--QFEILKCEELLLTAQLES 558
            Q++ A  E  +  +   + + +  Q+E +   L+LQL E   Q  +L  E   L A+   
Sbjct: 2296 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2355

Query: 559  IKRLISEKRDEV----VYYDTYESMEAMLEKEEMA--------ASAYLQREELQKLQQKA 606
              R  S+  +E+    V  +    ++A +E E  A           +LQ EE +K++Q A
Sbjct: 2356 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVA 2414

Query: 607  RQL--------EARRGRVSAKKSYLRNK--KEICIAKHNEKIQQRTRIEDE----YRTHH 652
             +         EA R R  A++   + +   E  + +  + +Q+ TR++ E     +   
Sbjct: 2415 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2474

Query: 653  TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA 712
              Q +  +L +++E+ +  +++E Q     L   +QR   ++  ++ RL+L  A    A 
Sbjct: 2475 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSAEAERLKLRVAEMSRAQ 2533

Query: 713  SPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLP 772
            +   +ED         +  ++ EE+GE ++ R    T E  +LVQ  +    Q +  +  
Sbjct: 2534 ARA-EED-------AQRFRKQAEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2584

Query: 773  LSGVTSEL 780
            L    +EL
Sbjct: 2585 LREAIAEL 2592



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 92/420 (21%), Positives = 155/420 (36%), Gaps = 61/420 (14%)

Query: 365  EDEAYSSLAEATTELYQYLLQPFRDMRE-LAMLRRQ-----QIKISMENDYLGPRRIESL 418
            EDEA+         L +   Q   D+ E LA LR+      + +  +  D L  RR   +
Sbjct: 2008 EDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR--QV 2060

Query: 419  QKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERME 478
            ++E    +     A     +L ++   I + A+  +  + +A+ +   +   AA  ER  
Sbjct: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120

Query: 479  KLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +      +   + + A+E    QRK AL EE++ L+   E   RL +        QLQL 
Sbjct: 2121 R---EAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQL- 2175

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                           AQ  + KRL +E                  EK    A    ++E 
Sbjct: 2176 ---------------AQEAAQKRLQAE------------------EKAHAFAVQQKEQEL 2202

Query: 599  LQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHT----- 653
             Q LQQ+   L+  RG   A +      +E  +    E  Q R ++E+  R   +     
Sbjct: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262

Query: 654  -----VQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                  Q   EKL  E E+++A  +Q  Q  L + +                LR      
Sbjct: 2263 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2322

Query: 709  KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEA 768
            +   +  LQ +  D   ++L  E +  +       R  SQ  E    V+++   L++L+A
Sbjct: 2323 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2382



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/432 (18%), Positives = 174/432 (40%), Gaps = 37/432 (8%)

Query: 335  LQRARKRIQELLDKHKNT--ESMVELLDLYQLEDEA--YSSLAEATTELYQYLLQPFRDM 390
            ++R R+R+ +LL++ +    ++ V   +L QL  +   Y   A+      Q   +    +
Sbjct: 1311 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1370

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            + + +   Q ++  +  +      IE   ++  + QR A   + +I+D  ++   +T KA
Sbjct: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL--VTYKA 1428

Query: 451  Q-KAVYDRMRADQKKFGKAS----WAAAAERMEKLQYAVSK------ETLQMMRAKEICL 499
            Q + V    +  + + G  S    +        +L    S+      ETL+ M  +E   
Sbjct: 1429 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1488

Query: 500  EQRKHALKEEMQSLRGGTEAIARLD--------QLEADYYDLQLQLYEVQFEILKCEELL 551
            EQ++   +E +  +    E   +L         Q E +  +LQ ++ E   E+++ EE  
Sbjct: 1489 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVRREEAA 1545

Query: 552  LTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
            + AQ +  KR I E+  ++      E      + E    S     EE++ ++ +    E 
Sbjct: 1546 VDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1603

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
            +RG    +   LR + E   A+  +  ++  R+  + +     + + E       +  A 
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663

Query: 672  VSQERQRTLDRLRTFK-------QRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSL 724
             ++E+QR L  L   +       +R     + ++ ++++A    + +A   LQ       
Sbjct: 1664 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1723

Query: 725  PSVLQVEEKTEE 736
                Q+E   +E
Sbjct: 1724 EKTAQLERSLQE 1735


>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 96/451 (21%), Positives = 192/451 (42%), Gaps = 35/451 (7%)

Query: 324  SELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            +E +++  +E  +R R+++Q+  +  +  ++ VEL    + E EA      A   L +  
Sbjct: 1463 AEAQKRQAQEEAERLRRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520

Query: 384  LQPF---RDMRELAMLRRQQIKISMENDYLGPRRIES-LQKEDADWQRKAHMAVLSIQDL 439
            LQ     R +R+  + R +Q+++++E      R  E+ LQ + A +  K      S+Q+ 
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALET---AQRSAEAELQSKRASFAEKTAQLERSLQEE 1577

Query: 440  TVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICL 499
             V   ++  +A++      RA Q+   + +   A   +E+ Q   ++     ++A+E+  
Sbjct: 1578 HVAVAQLREEAER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA- 1630

Query: 500  EQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
             Q+K   + E +  +   E  AR      +    Q +L E + E  K  +L   A+  + 
Sbjct: 1631 -QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE--KQRQL---AEGTAQ 1684

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            +RL +E+          E +    E E+      L  EEL +LQ++A     +R  + A+
Sbjct: 1685 QRLAAEQ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1734

Query: 620  KSYLRNKKEICIA-KHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQ 677
             + +R + E+ +A K   + + R+  E   +       +  +L +E  R  A   + +RQ
Sbjct: 1735 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1794

Query: 678  RTLDRLRTFKQRYPGQVILKSTRLRLAHARR-KGAASPVLQEDHCDSLPSVLQVEEKTEE 736
            R L      +QR   + +L      +  A R K  A   L+E   ++       E++  +
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854

Query: 737  VGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
                  +    +    + L QL   S ++LE
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELE 1885



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 141/652 (21%), Positives = 263/652 (40%), Gaps = 101/652 (15%)

Query: 152  QKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDA 211
            Q+ S  D   G A AA R A  EA+ + V+    +     ++E  E +K+     A + A
Sbjct: 2049 QEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2107

Query: 212  EQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLF 271
            +    A +L   AE+         Q  +A  +Q  + ++++E     F E+         
Sbjct: 2108 QAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQ----- 2158

Query: 272  GGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY-ESLSELRQKG 330
                   EQE+ TL  QL+                     ETD  +    E L  L+ + 
Sbjct: 2159 ---KAQVEQELTTLRLQLE---------------------ETDHQKNLLDEELQRLKAEA 2194

Query: 331  YEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDM 390
             E   QR++   +EL       E + +L    + E+ A     +  T+  ++L +    M
Sbjct: 2195 TEAARQRSQVE-EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKM 2251

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            +++A    +  ++S+        R+  L +ED   QR                    A A
Sbjct: 2252 KQVA---EEAARLSVAAQEAA--RLRQLAEEDLAQQR--------------------ALA 2286

Query: 451  QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
            +K + ++M+A Q+        A AE +++ +    ++  ++   KE   +Q    L EE 
Sbjct: 2287 EKMLKEKMQAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ----LAEET 2339

Query: 511  QSLRGGTEAIARLDQLE--ADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRD 568
            Q  +   EA  R  QLE  A+   L+L++ E+     + EE          +R    K+ 
Sbjct: 2340 QGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEE--------DAQRF--RKQA 2388

Query: 569  EVVYYDTYESMEAMLEKEEMAASAYLQREE----LQKLQQKARQLEARRGRVSAKKSYLR 624
            E +    + +  A  EK  +  +  +QR++     ++L++   +LE  + ++  +   L+
Sbjct: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2448

Query: 625  NKKEICIAKHNEKIQQRTR-IEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRL 683
             K E       E++ Q T+ ++  + +     L+RE+  ++E+ K   + Q+      +L
Sbjct: 2449 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2508

Query: 684  RTFKQRYPGQVILKSTRL--RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEV--GE 739
            R  +QR   Q+  +  RL   +  ARR+   +        + L  + Q   + EE+   E
Sbjct: 2509 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2568

Query: 740  GRVKRGPSQTTEPQ---SLVQLEDTSLTQLEAT-SLP-----LSGVTSELPP 782
             +  R   Q  E Q   +L   E+ + +Q+ AT +LP     L G  +E  P
Sbjct: 2569 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2620



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 102/488 (20%), Positives = 205/488 (42%), Gaps = 58/488 (11%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            E  +  R+   EEV +R + +++E     +  E   E     QL  EA     +A  + +
Sbjct: 1976 EEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ--ESARQLQLAQEAAQKRLQAEEKAH 2032

Query: 381  QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLT 440
             + +Q      +  + + Q +   +  +    RR    + E+A  Q +   A        
Sbjct: 2033 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAA-------- 2083

Query: 441  VKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLE 500
                +   + ++A   +  A+++   +A   AAAE++ K      +E  +  +A++  L 
Sbjct: 2084 ----QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK---EAEQEAARRAQAEQAALR 2136

Query: 501  QRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV--QFEILKCEELLLTAQLES 558
            Q++ A  E  +  +   + + +  Q+E +   L+LQL E   Q  +L  E   L A+   
Sbjct: 2137 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2196

Query: 559  IKRLISEKRDEV----VYYDTYESMEAMLEKEEMA--------ASAYLQREELQKLQQKA 606
              R  S+  +E+    V  +    ++A +E E  A           +LQ EE +K++Q A
Sbjct: 2197 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVA 2255

Query: 607  RQL--------EARRGRVSAKKSYLRNK--KEICIAKHNEKIQQRTRIEDE----YRTHH 652
             +         EA R R  A++   + +   E  + +  + +Q+ TR++ E     +   
Sbjct: 2256 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2315

Query: 653  TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA 712
              Q +  +L +++E+ +  +++E Q     L   +QR   ++  ++ RL+L  A    A 
Sbjct: 2316 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSAEAERLKLRVAEMSRAQ 2374

Query: 713  SPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLP 772
            +   +ED         +  ++ EE+GE ++ R    T E  +LVQ  +    Q +  +  
Sbjct: 2375 ARA-EED-------AQRFRKQAEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2425

Query: 773  LSGVTSEL 780
            L    +EL
Sbjct: 2426 LREAIAEL 2433



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 92/420 (21%), Positives = 155/420 (36%), Gaps = 61/420 (14%)

Query: 365  EDEAYSSLAEATTELYQYLLQPFRDMRE-LAMLRRQ-----QIKISMENDYLGPRRIESL 418
            EDEA+         L +   Q   D+ E LA LR+      + +  +  D L  RR   +
Sbjct: 1849 EDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR--QV 1901

Query: 419  QKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERME 478
            ++E    +     A     +L ++   I + A+  +  + +A+ +   +   AA  ER  
Sbjct: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961

Query: 479  KLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +      +   + + A+E    QRK AL EE++ L+   E   RL +        QLQL 
Sbjct: 1962 R---EAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQL- 2016

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                           AQ  + KRL +E                  EK    A    ++E 
Sbjct: 2017 ---------------AQEAAQKRLQAE------------------EKAHAFAVQQKEQEL 2043

Query: 599  LQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHT----- 653
             Q LQQ+   L+  RG   A +      +E  +    E  Q R ++E+  R   +     
Sbjct: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103

Query: 654  -----VQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                  Q   EKL  E E+++A  +Q  Q  L + +                LR      
Sbjct: 2104 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2163

Query: 709  KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEA 768
            +   +  LQ +  D   ++L  E +  +       R  SQ  E    V+++   L++L+A
Sbjct: 2164 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2223



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/432 (18%), Positives = 174/432 (40%), Gaps = 37/432 (8%)

Query: 335  LQRARKRIQELLDKHKNT--ESMVELLDLYQLEDEA--YSSLAEATTELYQYLLQPFRDM 390
            ++R R+R+ +LL++ +    ++ V   +L QL  +   Y   A+      Q   +    +
Sbjct: 1152 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1211

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            + + +   Q ++  +  +      IE   ++  + QR A   + +I+D  ++   +T KA
Sbjct: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL--VTYKA 1269

Query: 451  Q-KAVYDRMRADQKKFGKAS----WAAAAERMEKLQYAVSK------ETLQMMRAKEICL 499
            Q + V    +  + + G  S    +        +L    S+      ETL+ M  +E   
Sbjct: 1270 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1329

Query: 500  EQRKHALKEEMQSLRGGTEAIARLD--------QLEADYYDLQLQLYEVQFEILKCEELL 551
            EQ++   +E +  +    E   +L         Q E +  +LQ ++ E   E+++ EE  
Sbjct: 1330 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVRREEAA 1386

Query: 552  LTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
            + AQ +  KR I E+  ++      E      + E    S     EE++ ++ +    E 
Sbjct: 1387 VDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1444

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
            +RG    +   LR + E   A+  +  ++  R+  + +     + + E       +  A 
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504

Query: 672  VSQERQRTLDRLRTFK-------QRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSL 724
             ++E+QR L  L   +       +R     + ++ ++++A    + +A   LQ       
Sbjct: 1505 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1564

Query: 725  PSVLQVEEKTEE 736
                Q+E   +E
Sbjct: 1565 EKTAQLERSLQE 1576


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 96/451 (21%), Positives = 192/451 (42%), Gaps = 35/451 (7%)

Query: 324  SELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            +E +++  +E  +R R+++Q+  +  +  ++ VEL    + E EA      A   L +  
Sbjct: 1471 AEAQKRQAQEEAERLRRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1528

Query: 384  LQPF---RDMRELAMLRRQQIKISMENDYLGPRRIES-LQKEDADWQRKAHMAVLSIQDL 439
            LQ     R +R+  + R +Q+++++E      R  E+ LQ + A +  K      S+Q+ 
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALET---AQRSAEAELQSKRASFAEKTAQLERSLQEE 1585

Query: 440  TVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICL 499
             V   ++  +A++      RA Q+   + +   A   +E+ Q   ++     ++A+E+  
Sbjct: 1586 HVAVAQLREEAER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA- 1638

Query: 500  EQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
             Q+K   + E +  +   E  AR      +    Q +L E + E  K  +L   A+  + 
Sbjct: 1639 -QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE--KQRQL---AEGTAQ 1692

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            +RL +E+          E +    E E+      L  EEL +LQ++A     +R  + A+
Sbjct: 1693 QRLAAEQ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1742

Query: 620  KSYLRNKKEICIA-KHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQ 677
             + +R + E+ +A K   + + R+  E   +       +  +L +E  R  A   + +RQ
Sbjct: 1743 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1802

Query: 678  RTLDRLRTFKQRYPGQVILKSTRLRLAHARR-KGAASPVLQEDHCDSLPSVLQVEEKTEE 736
            R L      +QR   + +L      +  A R K  A   L+E   ++       E++  +
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862

Query: 737  VGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
                  +    +    + L QL   S ++LE
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELE 1893



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 141/652 (21%), Positives = 263/652 (40%), Gaps = 101/652 (15%)

Query: 152  QKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDA 211
            Q+ S  D   G A AA R A  EA+ + V+    +     ++E  E +K+     A + A
Sbjct: 2057 QEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2115

Query: 212  EQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLF 271
            +    A +L   AE+         Q  +A  +Q  + ++++E     F E+         
Sbjct: 2116 QAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQ----- 2166

Query: 272  GGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY-ESLSELRQKG 330
                   EQE+ TL  QL+                     ETD  +    E L  L+ + 
Sbjct: 2167 ---KAQVEQELTTLRLQLE---------------------ETDHQKNLLDEELQRLKAEA 2202

Query: 331  YEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDM 390
             E   QR++   +EL       E + +L    + E+ A     +  T+  ++L +    M
Sbjct: 2203 TEAARQRSQVE-EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKM 2259

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            +++A    +  ++S+        R+  L +ED   QR                    A A
Sbjct: 2260 KQVA---EEAARLSVAAQEAA--RLRQLAEEDLAQQR--------------------ALA 2294

Query: 451  QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
            +K + ++M+A Q+        A AE +++ +    ++  ++   KE   +Q    L EE 
Sbjct: 2295 EKMLKEKMQAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ----LAEET 2347

Query: 511  QSLRGGTEAIARLDQLE--ADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRD 568
            Q  +   EA  R  QLE  A+   L+L++ E+     + EE          +R    K+ 
Sbjct: 2348 QGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEE--------DAQRF--RKQA 2396

Query: 569  EVVYYDTYESMEAMLEKEEMAASAYLQREE----LQKLQQKARQLEARRGRVSAKKSYLR 624
            E +    + +  A  EK  +  +  +QR++     ++L++   +LE  + ++  +   L+
Sbjct: 2397 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2456

Query: 625  NKKEICIAKHNEKIQQRTR-IEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRL 683
             K E       E++ Q T+ ++  + +     L+RE+  ++E+ K   + Q+      +L
Sbjct: 2457 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2516

Query: 684  RTFKQRYPGQVILKSTRL--RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEV--GE 739
            R  +QR   Q+  +  RL   +  ARR+   +        + L  + Q   + EE+   E
Sbjct: 2517 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2576

Query: 740  GRVKRGPSQTTEPQ---SLVQLEDTSLTQLEAT-SLP-----LSGVTSELPP 782
             +  R   Q  E Q   +L   E+ + +Q+ AT +LP     L G  +E  P
Sbjct: 2577 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2628



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 102/488 (20%), Positives = 205/488 (42%), Gaps = 58/488 (11%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            E  +  R+   EEV +R + +++E     +  E   E     QL  EA     +A  + +
Sbjct: 1984 EEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ--ESARQLQLAQEAAQKRLQAEEKAH 2040

Query: 381  QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLT 440
             + +Q      +  + + Q +   +  +    RR    + E+A  Q +   A        
Sbjct: 2041 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAA-------- 2091

Query: 441  VKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLE 500
                +   + ++A   +  A+++   +A   AAAE++ K      +E  +  +A++  L 
Sbjct: 2092 ----QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK---EAEQEAARRAQAEQAALR 2144

Query: 501  QRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV--QFEILKCEELLLTAQLES 558
            Q++ A  E  +  +   + + +  Q+E +   L+LQL E   Q  +L  E   L A+   
Sbjct: 2145 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2204

Query: 559  IKRLISEKRDEV----VYYDTYESMEAMLEKEEMA--------ASAYLQREELQKLQQKA 606
              R  S+  +E+    V  +    ++A +E E  A           +LQ EE +K++Q A
Sbjct: 2205 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVA 2263

Query: 607  RQL--------EARRGRVSAKKSYLRNK--KEICIAKHNEKIQQRTRIEDE----YRTHH 652
             +         EA R R  A++   + +   E  + +  + +Q+ TR++ E     +   
Sbjct: 2264 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2323

Query: 653  TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA 712
              Q +  +L +++E+ +  +++E Q     L   +QR   ++  ++ RL+L  A    A 
Sbjct: 2324 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSAEAERLKLRVAEMSRAQ 2382

Query: 713  SPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLP 772
            +   +ED         +  ++ EE+GE ++ R    T E  +LVQ  +    Q +  +  
Sbjct: 2383 ARA-EED-------AQRFRKQAEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2433

Query: 773  LSGVTSEL 780
            L    +EL
Sbjct: 2434 LREAIAEL 2441



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 92/420 (21%), Positives = 155/420 (36%), Gaps = 61/420 (14%)

Query: 365  EDEAYSSLAEATTELYQYLLQPFRDMRE-LAMLRRQ-----QIKISMENDYLGPRRIESL 418
            EDEA+         L +   Q   D+ E LA LR+      + +  +  D L  RR   +
Sbjct: 1857 EDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR--QV 1909

Query: 419  QKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERME 478
            ++E    +     A     +L ++   I + A+  +  + +A+ +   +   AA  ER  
Sbjct: 1910 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1969

Query: 479  KLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +      +   + + A+E    QRK AL EE++ L+   E   RL +        QLQL 
Sbjct: 1970 R---EAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQL- 2024

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                           AQ  + KRL +E                  EK    A    ++E 
Sbjct: 2025 ---------------AQEAAQKRLQAE------------------EKAHAFAVQQKEQEL 2051

Query: 599  LQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHT----- 653
             Q LQQ+   L+  RG   A +      +E  +    E  Q R ++E+  R   +     
Sbjct: 2052 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2111

Query: 654  -----VQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                  Q   EKL  E E+++A  +Q  Q  L + +                LR      
Sbjct: 2112 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2171

Query: 709  KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEA 768
            +   +  LQ +  D   ++L  E +  +       R  SQ  E    V+++   L++L+A
Sbjct: 2172 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2231



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/432 (18%), Positives = 174/432 (40%), Gaps = 37/432 (8%)

Query: 335  LQRARKRIQELLDKHKNT--ESMVELLDLYQLEDEA--YSSLAEATTELYQYLLQPFRDM 390
            ++R R+R+ +LL++ +    ++ V   +L QL  +   Y   A+      Q   +    +
Sbjct: 1160 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1219

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            + + +   Q ++  +  +      IE   ++  + QR A   + +I+D  ++   +T KA
Sbjct: 1220 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL--VTYKA 1277

Query: 451  Q-KAVYDRMRADQKKFGKAS----WAAAAERMEKLQYAVSK------ETLQMMRAKEICL 499
            Q + V    +  + + G  S    +        +L    S+      ETL+ M  +E   
Sbjct: 1278 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1337

Query: 500  EQRKHALKEEMQSLRGGTEAIARLD--------QLEADYYDLQLQLYEVQFEILKCEELL 551
            EQ++   +E +  +    E   +L         Q E +  +LQ ++ E   E+++ EE  
Sbjct: 1338 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVRREEAA 1394

Query: 552  LTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
            + AQ +  KR I E+  ++      E      + E    S     EE++ ++ +    E 
Sbjct: 1395 VDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1452

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
            +RG    +   LR + E   A+  +  ++  R+  + +     + + E       +  A 
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512

Query: 672  VSQERQRTLDRLRTFK-------QRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSL 724
             ++E+QR L  L   +       +R     + ++ ++++A    + +A   LQ       
Sbjct: 1513 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1572

Query: 725  PSVLQVEEKTEE 736
                Q+E   +E
Sbjct: 1573 EKTAQLERSLQE 1584


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 96/451 (21%), Positives = 192/451 (42%), Gaps = 35/451 (7%)

Query: 324  SELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYL 383
            +E +++  +E  +R R+++Q+  +  +  ++ VEL    + E EA      A   L +  
Sbjct: 1512 AEAQKRQAQEEAERLRRQVQD--ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569

Query: 384  LQPF---RDMRELAMLRRQQIKISMENDYLGPRRIES-LQKEDADWQRKAHMAVLSIQDL 439
            LQ     R +R+  + R +Q+++++E      R  E+ LQ + A +  K      S+Q+ 
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALET---AQRSAEAELQSKRASFAEKTAQLERSLQEE 1626

Query: 440  TVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICL 499
             V   ++  +A++      RA Q+   + +   A   +E+ Q   ++     ++A+E+  
Sbjct: 1627 HVAVAQLREEAER------RAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVA- 1679

Query: 500  EQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLTAQLESI 559
             Q+K   + E +  +   E  AR      +    Q +L E + E  K  +L   A+  + 
Sbjct: 1680 -QQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE--KQRQL---AEGTAQ 1733

Query: 560  KRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAK 619
            +RL +E+          E +    E E+      L  EEL +LQ++A     +R  + A+
Sbjct: 1734 QRLAAEQ----------ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1783

Query: 620  KSYLRNKKEICIA-KHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQ-ERQ 677
             + +R + E+ +A K   + + R+  E   +       +  +L +E  R  A   + +RQ
Sbjct: 1784 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ 1843

Query: 678  RTLDRLRTFKQRYPGQVILKSTRLRLAHARR-KGAASPVLQEDHCDSLPSVLQVEEKTEE 736
            R L      +QR   + +L      +  A R K  A   L+E   ++       E++  +
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903

Query: 737  VGEGRVKRGPSQTTEPQSLVQLEDTSLTQLE 767
                  +    +    + L QL   S ++LE
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELE 1934



 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 141/652 (21%), Positives = 263/652 (40%), Gaps = 101/652 (15%)

Query: 152  QKTSEADDAAGAAAAAARPAPREAQVSSVRIVSASGTVSEEIEVLEMVKEDEAPLALSDA 211
            Q+ S  D   G A AA R A  EA+ + V+    +     ++E  E +K+     A + A
Sbjct: 2098 QEQSVLDQLRGEAEAARRAA-EEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARA 2156

Query: 212  EQPPPATELESPAEECSWAGLFSFQDLRAVHQQLCSVNSQLEPCLPVFPEEPSGMWTVLF 271
            +    A +L   AE+         Q  +A  +Q  + ++++E     F E+         
Sbjct: 2157 QAQAAAEKLRKEAEQ---EAARRAQAEQAALRQKQAADAEMEKHKK-FAEQTLRQ----- 2207

Query: 272  GGAPEMTEQEIDTLCYQLQVYLGHGLDTCGWKILSQVLFTETDDPEEYY-ESLSELRQKG 330
                   EQE+ TL  QL+                     ETD  +    E L  L+ + 
Sbjct: 2208 ---KAQVEQELTTLRLQLE---------------------ETDHQKNLLDEELQRLKAEA 2243

Query: 331  YEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDM 390
             E   QR++   +EL       E + +L    + E+ A     +  T+  ++L +    M
Sbjct: 2244 TEAARQRSQVE-EELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ--RFLQEEAEKM 2300

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            +++A    +  ++S+        R+  L +ED   QR                    A A
Sbjct: 2301 KQVA---EEAARLSVAAQEAA--RLRQLAEEDLAQQR--------------------ALA 2335

Query: 451  QKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEM 510
            +K + ++M+A Q+        A AE +++ +    ++  ++   KE   +Q    L EE 
Sbjct: 2336 EKMLKEKMQAVQEA---TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQ----LAEET 2388

Query: 511  QSLRGGTEAIARLDQLE--ADYYDLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRD 568
            Q  +   EA  R  QLE  A+   L+L++ E+     + EE          +R    K+ 
Sbjct: 2389 QGFQRTLEA-ERQRQLEMSAEAERLKLRVAEMSRAQARAEE--------DAQRF--RKQA 2437

Query: 569  EVVYYDTYESMEAMLEKEEMAASAYLQREE----LQKLQQKARQLEARRGRVSAKKSYLR 624
            E +    + +  A  EK  +  +  +QR++     ++L++   +LE  + ++  +   L+
Sbjct: 2438 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQ 2497

Query: 625  NKKEICIAKHNEKIQQRTR-IEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRL 683
             K E       E++ Q T+ ++  + +     L+RE+  ++E+ K   + Q+      +L
Sbjct: 2498 LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQL 2557

Query: 684  RTFKQRYPGQVILKSTRL--RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEV--GE 739
            R  +QR   Q+  +  RL   +  ARR+   +        + L  + Q   + EE+   E
Sbjct: 2558 REEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE 2617

Query: 740  GRVKRGPSQTTEPQ---SLVQLEDTSLTQLEAT-SLP-----LSGVTSELPP 782
             +  R   Q  E Q   +L   E+ + +Q+ AT +LP     L G  +E  P
Sbjct: 2618 NQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2669



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 102/488 (20%), Positives = 205/488 (42%), Gaps = 58/488 (11%)

Query: 321  ESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELY 380
            E  +  R+   EEV +R + +++E     +  E   E     QL  EA     +A  + +
Sbjct: 2025 EEAARQRKAALEEV-ERLKAKVEEARRLRERAEQ--ESARQLQLAQEAAQKRLQAEEKAH 2081

Query: 381  QYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLT 440
             + +Q      +  + + Q +   +  +    RR    + E+A  Q +   A        
Sbjct: 2082 AFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE-EAEEARVQAEREAA-------- 2132

Query: 441  VKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLE 500
                +   + ++A   +  A+++   +A   AAAE++ K      +E  +  +A++  L 
Sbjct: 2133 ----QSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK---EAEQEAARRAQAEQAALR 2185

Query: 501  QRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEV--QFEILKCEELLLTAQLES 558
            Q++ A  E  +  +   + + +  Q+E +   L+LQL E   Q  +L  E   L A+   
Sbjct: 2186 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE 2245

Query: 559  IKRLISEKRDEV----VYYDTYESMEAMLEKEEMA--------ASAYLQREELQKLQQKA 606
              R  S+  +E+    V  +    ++A +E E  A           +LQ EE +K++Q A
Sbjct: 2246 AARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ-EEAEKMKQVA 2304

Query: 607  RQL--------EARRGRVSAKKSYLRNK--KEICIAKHNEKIQQRTRIEDE----YRTHH 652
             +         EA R R  A++   + +   E  + +  + +Q+ TR++ E     +   
Sbjct: 2305 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2364

Query: 653  TVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAA 712
              Q +  +L +++E+ +  +++E Q     L   +QR   ++  ++ RL+L  A    A 
Sbjct: 2365 LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL-EMSAEAERLKLRVAEMSRAQ 2423

Query: 713  SPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLP 772
            +   +ED         +  ++ EE+GE ++ R    T E  +LVQ  +    Q +  +  
Sbjct: 2424 ARA-EED-------AQRFRKQAEEIGE-KLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2474

Query: 773  LSGVTSEL 780
            L    +EL
Sbjct: 2475 LREAIAEL 2482



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 92/420 (21%), Positives = 155/420 (36%), Gaps = 61/420 (14%)

Query: 365  EDEAYSSLAEATTELYQYLLQPFRDMRE-LAMLRRQ-----QIKISMENDYLGPRRIESL 418
            EDEA+         L +   Q   D+ E LA LR+      + +  +  D L  RR   +
Sbjct: 1898 EDEAFQR-----RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRR--QV 1950

Query: 419  QKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERME 478
            ++E    +     A     +L ++   I + A+  +  + +A+ +   +   AA  ER  
Sbjct: 1951 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2010

Query: 479  KLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLY 538
            +      +   + + A+E    QRK AL EE++ L+   E   RL +        QLQL 
Sbjct: 2011 R---EAEERVQKSLAAEEEAARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQL- 2065

Query: 539  EVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREE 598
                           AQ  + KRL +E                  EK    A    ++E 
Sbjct: 2066 ---------------AQEAAQKRLQAE------------------EKAHAFAVQQKEQEL 2092

Query: 599  LQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHT----- 653
             Q LQQ+   L+  RG   A +      +E  +    E  Q R ++E+  R   +     
Sbjct: 2093 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2152

Query: 654  -----VQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARR 708
                  Q   EKL  E E+++A  +Q  Q  L + +                LR      
Sbjct: 2153 QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVE 2212

Query: 709  KGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEA 768
            +   +  LQ +  D   ++L  E +  +       R  SQ  E    V+++   L++L+A
Sbjct: 2213 QELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKA 2272



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 81/432 (18%), Positives = 174/432 (40%), Gaps = 37/432 (8%)

Query: 335  LQRARKRIQELLDKHKNT--ESMVELLDLYQLEDEA--YSSLAEATTELYQYLLQPFRDM 390
            ++R R+R+ +LL++ +    ++ V   +L QL  +   Y   A+      Q   +    +
Sbjct: 1201 VERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1260

Query: 391  RELAMLRRQQIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKA 450
            + + +   Q ++  +  +      IE   ++  + QR A   + +I+D  ++   +T KA
Sbjct: 1261 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL--VTYKA 1318

Query: 451  Q-KAVYDRMRADQKKFGKAS----WAAAAERMEKLQYAVSK------ETLQMMRAKEICL 499
            Q + V    +  + + G  S    +        +L    S+      ETL+ M  +E   
Sbjct: 1319 QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLA 1378

Query: 500  EQRKHALKEEMQSLRGGTEAIARLD--------QLEADYYDLQLQLYEVQFEILKCEELL 551
            EQ++   +E +  +    E   +L         Q E +  +LQ ++ E   E+++ EE  
Sbjct: 1379 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQE---EVVRREEAA 1435

Query: 552  LTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
            + AQ +  KR I E+  ++      E      + E    S     EE++ ++ +    E 
Sbjct: 1436 VDAQQQ--KRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATER 1493

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
            +RG    +   LR + E   A+  +  ++  R+  + +     + + E       +  A 
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553

Query: 672  VSQERQRTLDRLRTFK-------QRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSL 724
             ++E+QR L  L   +       +R     + ++ ++++A    + +A   LQ       
Sbjct: 1554 AAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFA 1613

Query: 725  PSVLQVEEKTEE 736
                Q+E   +E
Sbjct: 1614 EKTAQLERSLQE 1625


>gi|87116683 proline/serine-rich coiled-coil 2 [Homo sapiens]
          Length = 1989

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 81/348 (23%), Positives = 140/348 (40%), Gaps = 34/348 (9%)

Query: 585 KEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRI 644
           KE++  +  +Q    QK++   +   A++   +AK++  + + +       +K Q+R + 
Sbjct: 398 KEKLTKTKTVQ----QKVKTSTKTHSAKKVSTTAKQALRKQQTKAWKKLQQQKEQERQKE 453

Query: 645 EDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLA 704
           ED+          R++  +EE RK     +E  R +  L   +++Y   + L   + R  
Sbjct: 454 EDQ----------RKQAEEEERRKR----EEEIRKIRDLSNQEEQYNRFMKLVGGKRRSR 499

Query: 705 HARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQSLVQLEDTSL- 763
                      L +   DS   + Q +   EEV         S    P       + SL 
Sbjct: 500 SKSSDPDLRRSLDKQPTDSGGGIYQYDNY-EEVAMDTDSETSSPAPSPVQPPFFSECSLG 558

Query: 764 --TQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPP 821
             +   + SLP     S LPP +S P +    E   V++ PLP PLPP PP PP  P  P
Sbjct: 559 YFSPAPSLSLPPPPQVSSLPP-LSQPYV----EGLCVSLEPLP-PLPPLPPLPPEDPEQP 612

Query: 822 PPPPLPVAKDSGPETLEKDLPRKEGNEKRI-PKSASA----PSAHLFDSSQLVSARKKLR 876
           P PP    ++     L ++L +   N++   P+  S+    PS  + ++S  V       
Sbjct: 613 PKPPFADEEEEEEMLLREELLKSLANKRAFKPEETSSNSDPPSPPVLNNSHPVPRSNLSI 672

Query: 877 KTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQRTLPPFPDEDDSNN 924
            +   + + R+ +P       L R    L K  +  +    D DDS +
Sbjct: 673 VSINTVSQPRIQNPKFHRGPRLPRTVISLPK-HKSVVVTLNDSDDSES 719


>gi|126090663 zinc finger homeodomain 4 [Homo sapiens]
          Length = 3571

 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 30/65 (46%), Positives = 34/65 (52%), Gaps = 2/65 (3%)

Query: 780  LPPTISLPLLNNNLEPCSVTINPL--PSPLPPTPPPPPPPPPPPPPPPLPVAKDSGPETL 837
            LPP    P     ++  +    PL  P P PP PPPPPPPPPPPPPPP P A       +
Sbjct: 1967 LPPAPPQPSSMGPVKIPNTVSTPLQAPPPTPPPPPPPPPPPPPPPPPPPPSAPPQVQLPV 2026

Query: 838  EKDLP 842
              DLP
Sbjct: 2027 SLDLP 2031



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 29/60 (48%), Positives = 34/60 (56%), Gaps = 18/60 (30%)

Query: 779  ELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPPPPPPPPPPPPPPP-------LPVAKD 831
            ++P T+S PL             P P+P PP PPPPPPPPPPPPPPP       LPV+ D
Sbjct: 1981 KIPNTVSTPLQA-----------PPPTPPPPPPPPPPPPPPPPPPPPSAPPQVQLPVSLD 2029



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 59/258 (22%), Positives = 108/258 (41%), Gaps = 32/258 (12%)

Query: 585  KEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRI 644
            K+++    ++ + +LQ LQQ+A+Q +A + ++  +K   +           ++ QQ +++
Sbjct: 1734 KQQIQTQHHVGQTQLQILQQQAQQYQATQPQLQPQKQQQQPPPP-----QQQQQQQASKL 1788

Query: 645  EDEYRTHHTVQ----LKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVILKSTR 700
              + +++        +K    + E E  S    + +Q  +      K+   G+   K   
Sbjct: 1789 LKQEQSNIVSADCQIMKDVPSYKEAEDISEKPEKPKQEFISEGEGLKE---GKDTKKQKS 1845

Query: 701  L-------RLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEPQ 753
            L       R+A   R  AA  +L+         V+Q  E  ++V + + K G  + T+  
Sbjct: 1846 LEPSIPPPRIASGARGNAAKALLENF---GFELVIQYNENRQKV-QKKGKSGEGENTD-- 1899

Query: 754  SLVQLEDTSLTQLEATSLPLSG----VTSELPPTISLPLLNNNLEPCSVTINPLPSPLPP 809
               +LE  +  +L +  L L      V  +  P  +L             + P+    P 
Sbjct: 1900 ---KLECGTCGKLFSNVLILKSHQEHVHGQFFPYAALEKFARQYREAYDKLYPISPSSPE 1956

Query: 810  TPPPPPPPPPPPPPPPLP 827
            TPPPPPPPPP PP PP P
Sbjct: 1957 TPPPPPPPPPLPPAPPQP 1974



 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 30/93 (32%), Positives = 39/93 (41%), Gaps = 10/93 (10%)

Query: 795  PCSVTINPLPS----PLPPTPPPPPPPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKR 850
            P S T +P  S    P  P    PPPPPPPPPPPP         E   K+  +K+    +
Sbjct: 3094 PTSATSSPALSLSSAPTKPLLQTPPPPPPPPPPPPSSSLSGQQTEQQNKESEKKQTKPNK 3153

Query: 851  IPK------SASAPSAHLFDSSQLVSARKKLRK 877
            + K       A+ P  H     ++ SA   L K
Sbjct: 3154 VKKIKEEELEATKPEKHPKKEEKISSALSVLGK 3186



 Score = 33.9 bits (76), Expect = 0.77
 Identities = 37/154 (24%), Positives = 54/154 (35%), Gaps = 26/154 (16%)

Query: 693  QVILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVEEKTEEVGEGRVKRGPSQTTEP 752
            QV+ K   +       K AA+P        S P +   + + E       K  P      
Sbjct: 2313 QVVYKHCTVSGQTDAAKNAAAPAASSGSGTSTPLIPSPKPEPE-------KTSPKPEYPA 2365

Query: 753  QSLVQLEDTSLTQLEATSLPLSGVTSELPPTISLPLLNNNLEPCSVTINPLPSPLPPTPP 812
            +   Q + +  +Q    +LPL+  +S+ PP  S             T  P P P PP  P
Sbjct: 2366 EKPKQSDPSPPSQGTKPALPLASTSSD-PPQAS-------------TAQPQPQPQPPKQP 2411

Query: 813  -----PPPPPPPPPPPPPLPVAKDSGPETLEKDL 841
                 PP     P P  PL ++  S   +L   L
Sbjct: 2412 QLIGRPPSASQTPVPSSPLQISMTSLQNSLPPQL 2445


>gi|150378503 leiomodin 2 (cardiac) [Homo sapiens]
          Length = 547

 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 50/150 (33%), Positives = 69/150 (46%), Gaps = 28/150 (18%)

Query: 795 PCSVTINPLPSPLPPTPPPPP----PPPPPPPPPPLPVAKDSGPETLEKDLPRKEGNEKR 850
           P S    P P P PP PPPP     PPPPPPPPPPLP          EK L  +   E  
Sbjct: 414 PLSPVATPPPPPPPPPPPPPSSQRLPPPPPPPPPPLP----------EKKLITRNIAEV- 462

Query: 851 IPKSASAPSAHLFDSSQLVSARKKLRKTAEGLQRRRVSSPMDEVLASLKRGSFHLKKVEQ 910
           I +  SA  A    + Q     KK++K        + +S + E+  SL+  S   KK+E 
Sbjct: 463 IKQQESAQRA--LQNGQKKKKGKKVKK--------QPNSILKEIKNSLR--SVQEKKMED 510

Query: 911 RTLPPFPDEDDSNNILAQIRKGVKLKKVQK 940
            + P  P      N++  IR G  +K++++
Sbjct: 511 SSRPSTPQRSAHENLMEAIR-GSSIKQLKR 539


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 112/473 (23%), Positives = 188/473 (39%), Gaps = 72/473 (15%)

Query: 343  QELLDKHKN--------TESMVELLDLY-QLEDE--AYSSLAEATTELYQYLLQPFRDMR 391
            +ELL+K  N        T+   +LL L  QLE++  AYSS+A    EL Q L++    +R
Sbjct: 676  EELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELEQELMEKNEKIR 735

Query: 392  EL-----------AMLRRQQIKISMENDYLGPRRIESL--QKEDADWQRKAHMAVLSI-- 436
             L            +   +  KI +E      ++IE L  Q E  D Q K     +S+  
Sbjct: 736  SLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEKKDQQFKEQEKTMSMLQ 795

Query: 437  QDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETL---QMMR 493
            QD+  K   + +       DR+  + K   K       E ++ LQ  VS+ET+   Q+  
Sbjct: 796  QDIICKQHHLES------LDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDS 849

Query: 494  AKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKCEELLLT 553
            A EIC E                 E +  L+QLE +    + QL +      K EE+   
Sbjct: 850  ALEICKE-----------------ELVLHLNQLEGNKEKFEKQLKK------KSEEVYCL 886

Query: 554  AQLESIKR--LISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQRE-ELQKLQQKARQLE 610
             +   IK   L       V+   T +  + ML++E +        + +L+K   K  Q  
Sbjct: 887  QKELKIKNHSLQETSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQEL 946

Query: 611  ARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSA 670
             ++   SA+K  LR  +E C +  +E   +R ++ +   T   V+++ ++  +E  +   
Sbjct: 947  QKQRESSAEK--LRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEK 1004

Query: 671  WVSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQV 730
             +   ++   ++     Q     +IL  T+  L            LQ      L   LQ 
Sbjct: 1005 EIMHLKRDGENKAMHLSQL---DMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQK 1061

Query: 731  EEKTE---EVGEGRVKRGPSQTTEPQSLVQLEDTSLTQLEATSLPLSGVTSEL 780
             E  E   +   G +K    Q  E + ++Q    SL +   T   +  +T+EL
Sbjct: 1062 REVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTT---IKDLTAEL 1111



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 90/440 (20%), Positives = 174/440 (39%), Gaps = 65/440 (14%)

Query: 332  EEVLQRARKRIQELLDKHKNTESMVELLDLYQLEDEAYSSLAEATTELYQYLLQPFRDMR 391
            +++LQ+   R  EL D     E  V  L+      +      E++ E  + + +      
Sbjct: 915  QQMLQQETIRNGELEDTQTKLEKQVSKLE------QELQKQRESSAEKLRKMEEKCESAA 968

Query: 392  ELAMLRRQ----------QIKISMENDYLGPRRIESLQKEDADWQRKAHMAVLSIQDLTV 441
              A L+RQ          Q+KI M+        +  ++KE    +R      + +  L  
Sbjct: 969  HEADLKRQKVIELTGTARQVKIEMDQY---KEELSKMEKEIMHLKRDGENKAMHLSQLD- 1024

Query: 442  KYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVSKETLQMMRAKEICLEQ 501
                            M  DQ K        A + +EKLQ++   E  + ++ +E+   +
Sbjct: 1025 ----------------MILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETE 1068

Query: 502  RKHALKEEMQSLRGGTE-------AIARLDQLEADYYDLQLQLYEVQFEI--LKCEELLL 552
             ++A  E   +LR   E       A   L++      DL  +L E + EI   K E L +
Sbjct: 1069 LQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEM 1128

Query: 553  TAQLESIKRLISEKRDEVVYYD-TYESMEAMLEKEEMAASAYLQREELQKLQQKARQLEA 611
               L+     + ++  +V + D T       +E++ +     L++ EL+ L++  +Q+E+
Sbjct: 1129 DQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELE-LKECNKQIES 1187

Query: 612  RRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAW 671
               ++   K  LR K+ I +    E  Q +  IE   RT   ++ + E +  E+E+  A 
Sbjct: 1188 LNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIE---RTQQRMK-EMESVMKEQEQYIAT 1243

Query: 672  VSQERQRTLDRLRTFKQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPSVLQVE 731
              +E       LR  +++      ++++   LA AR +   +    E     L  + Q+ 
Sbjct: 1244 QYKEAIDLGQELRLTREQ------VQNSHTELAEARHQQVQAQREIERLSSELEDMKQLS 1297

Query: 732  EK--------TEEVGEGRVK 743
            ++         EE+G  +V+
Sbjct: 1298 KEKDAHGNHLAEELGASKVR 1317



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 107/489 (21%), Positives = 198/489 (40%), Gaps = 65/489 (13%)

Query: 306 SQVLFTETDDPEEYYESLSELRQKGYEEVLQRARKRIQELLDKHKNTESMVELLDLYQLE 365
           S+V+   T+  +   +  SEL  K  +E+L+     + E  +      +  E LDL Q E
Sbjct: 445 SEVMAQLTESRQSILKLESELENK--DEILRDKFSLMNENRELKVRVAAQNERLDLCQQE 502

Query: 366 DEAYSSLAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYLGPRRIESLQKEDADW 425
            E+      +  ++   L  P +  REL   +           YL   ++ S   ++   
Sbjct: 503 IESSRVELRSLEKIISQL--PLK--RELFGFK----------SYLSKYQMSSFSNKEDRC 548

Query: 426 QRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAAAERMEKLQYAVS 485
                   L I +L +K     A+ QK ++  + A+Q      +   + E  +       
Sbjct: 549 IGCCEANKLVISELRIKLAIKEAEIQK-LHANLTANQLSQSLITCNDSQESSKLSSLETE 607

Query: 486 KETLQMMRAKEICLEQRKHAL-----KEEMQSLRGGTEAIARLDQLEADYYDLQLQLYE- 539
              L   +  E   +Q +H +     KE  + + G  E   +L Q+EA+  DL++ +   
Sbjct: 608 PVKLGGHQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIEAENSDLKVNMAHR 667

Query: 540 -VQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESM--EAMLEKEEMAASAYLQR 596
             QF++++ EELL  A   S  +L SE   +     T E    E ++    +AA      
Sbjct: 668 TSQFQLIQ-EELLEKASNSS--KLESEMTKKCSQLLTLEKQLEEKIVAYSSIAAKNAELE 724

Query: 597 EELQKLQQKARQLEARRGRVSAKKSYLRNK-KEICIAKHNEKIQQRTRIEDEYRTHHTVQ 655
           +EL +  +K R LE        K      K K+I + +H E  +Q  R+E +        
Sbjct: 725 QELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLE------ 778

Query: 656 LKREKLHDEEERKSAWVSQE------RQRTLDRLRT------FKQRYPGQVILKSTRLRL 703
            K+++   E+E+  + + Q+         +LDRL T       K+       LK+ + ++
Sbjct: 779 -KKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQV 837

Query: 704 AH----ARRKGAASPVLQED---HCDSLPS-----VLQVEEKTEEV----GEGRVKRGPS 747
           +      R+  +A  + +E+   H + L         Q+++K+EEV     E ++K    
Sbjct: 838 SEETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSL 897

Query: 748 QTTEPQSLV 756
           Q T  Q+++
Sbjct: 898 QETSEQNVI 906



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 47/203 (23%), Positives = 90/203 (44%), Gaps = 23/203 (11%)

Query: 486 KETLQMMRAKEICLEQRKHALKEEMQSLRGG-TEAIARLDQLE------ADYYDLQLQLY 538
           +E L  +R +  CL  + H+L  + +S+    T++ A++  LE      A    L+ Q+ 
Sbjct: 235 REKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSMLESAQQQAASVPILEEQII 294

Query: 539 EVQFEILKCEELLLTAQ--LESIKRLISEKRDEV---------VYYDTYESMEAMLEKEE 587
            ++ E+   +++L  A+  LE  ++++ EK   +         +  D  E  +     E 
Sbjct: 295 NLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQGKRAER 354

Query: 588 MAASAYLQREELQK-LQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRT---R 643
               A    EEL K  QQ  +++  +  +V A++  L      C  K N+++Q+R    +
Sbjct: 355 QRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLTNC-EKENKRLQERCGLYK 413

Query: 644 IEDEYRTHHTVQLKREKLHDEEE 666
            E E       QLK E  + +E+
Sbjct: 414 SELEILKEKLRQLKEENNNGKEK 436



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 58/272 (21%), Positives = 117/272 (43%), Gaps = 20/272 (7%)

Query: 414 RIESLQKEDADWQRKAHMAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKKFGKASWAAA 473
           ++  L++++A    + H  +   + +   +FE+T    K     + + Q++   AS    
Sbjct: 237 KLNKLRQQNACLVTQNHSLMTKFESI---HFELTQSRAKV--SMLESAQQQ--AASVPIL 289

Query: 474 AERMEKLQYAVSKETLQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARL--DQLEADYY 531
            E++  L+  VS +  +++R  E  LEQ +  + E+ QSL+   E   +L  D LE    
Sbjct: 290 EEQIINLEAEVSAQD-KVLREAENKLEQSQKMVIEKEQSLQESKEECIKLKVDLLEQTKQ 348

Query: 532 DLQLQLYEVQFEILKCEELLLTAQLESIKRLISEKRDEVVYYDTYESMEAML-----EKE 586
             + +    +  +   EEL  +   +  K+ ++EK ++V   +  E +E  L     E +
Sbjct: 349 GKRAERQRNE-ALYNAEEL--SKAFQQYKKKVAEKLEKVQAEE--EILERNLTNCEKENK 403

Query: 587 EMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIED 646
            +     L + EL+ L++K RQL+        K   +  K    +A+  E  Q   ++E 
Sbjct: 404 RLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLES 463

Query: 647 EYRTHHTVQLKREKLHDEEERKSAWVSQERQR 678
           E      +   +  L +E       V+ + +R
Sbjct: 464 ELENKDEILRDKFSLMNENRELKVRVAAQNER 495


>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
          Length = 1697

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 106/494 (21%), Positives = 217/494 (43%), Gaps = 55/494 (11%)

Query: 315 DPEEYYESLSELRQKGYEEVLQ-RARKRIQELLDKHKNTESM--VELLDLYQLEDEAYSS 371
           + EE+     EL+++ +++ L+   R   Q  L++ +  E    +E  +  + E E    
Sbjct: 400 EKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRR 459

Query: 372 LAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYL-GPRRIESLQKEDADWQRKAH 430
           L        + L Q  R+  E+  L  ++  + +E + L G  +  S + +D   +++  
Sbjct: 460 LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQ 519

Query: 431 MAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKK--FGKASWAAAAERMEKLQYAVSKET 488
              L + D   K  ++     K +   ++  Q K  +         ER++ +Q++ + ++
Sbjct: 520 KTELEVLD---KQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576

Query: 489 -LQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKC 547
            + ++  K +  E+    LKE++ +L    E  ++L ++  D ++ QL+   +   +L+C
Sbjct: 577 GVSLLHKKSLEKEELCQRLKEQLDALE--KETASKLSEM--DSFNNQLKCGNMDDSVLQC 632

Query: 548 EELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKAR 607
              LL+  L ++  L+ E R+    Y+T +     L K +      ++R+ L+ +Q+K  
Sbjct: 633 LLSLLSC-LNNLFLLLKELRET---YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL 688

Query: 608 QLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEER 667
           + EA R     K++  +      + K  E+ Q+R +   E +T   +Q        EEER
Sbjct: 689 EDEAARKAKQGKENLWKEN----LRKEEEEKQKRLQ---EEKTQEKIQ--------EEER 733

Query: 668 KSAWVSQERQRTLDRLRTF-KQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPS 726
           K+    +++++  D L+   K+R    V++    L    AR          ++   +   
Sbjct: 734 KA---EEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARN--------HDEMSFNSGD 782

Query: 727 VLQVEEKTEEVGEGRVKRGPSQTTE---PQSLVQLEDTSLTQLEATSLPLSGVTSELPPT 783
           ++QV+EKT  VGE     G  Q      P + V+   +S  +       +S   + LPPT
Sbjct: 783 IIQVDEKT--VGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKA-----VSPKKALLPPT 835

Query: 784 ISLPLLNNNLEPCS 797
           +SL   + + EP S
Sbjct: 836 VSLSATSTSSEPLS 849



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 30/130 (23%), Positives = 58/130 (44%), Gaps = 8/130 (6%)

Query: 576 YESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHN 635
           YE     LEK   A     QRE  +K Q++  + E ++  +  ++     KK++ + K  
Sbjct: 371 YERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEW----KKQLELEKRL 426

Query: 636 EKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVI 695
           EK ++  R  +E R     + +  K   E +R+  W    RQ  L++    K R   +++
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQ----KNREQEEIV 482

Query: 696 LKSTRLRLAH 705
             +++ +  H
Sbjct: 483 RLNSKKKNLH 492


>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
          Length = 1249

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 106/494 (21%), Positives = 217/494 (43%), Gaps = 55/494 (11%)

Query: 315 DPEEYYESLSELRQKGYEEVLQ-RARKRIQELLDKHKNTESM--VELLDLYQLEDEAYSS 371
           + EE+     EL+++ +++ L+   R   Q  L++ +  E    +E  +  + E E    
Sbjct: 400 EKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRR 459

Query: 372 LAEATTELYQYLLQPFRDMRELAMLRRQQIKISMENDYL-GPRRIESLQKEDADWQRKAH 430
           L        + L Q  R+  E+  L  ++  + +E + L G  +  S + +D   +++  
Sbjct: 460 LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQ 519

Query: 431 MAVLSIQDLTVKYFEITAKAQKAVYDRMRADQKK--FGKASWAAAAERMEKLQYAVSKET 488
              L + D   K  ++     K +   ++  Q K  +         ER++ +Q++ + ++
Sbjct: 520 KTELEVLD---KQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576

Query: 489 -LQMMRAKEICLEQRKHALKEEMQSLRGGTEAIARLDQLEADYYDLQLQLYEVQFEILKC 547
            + ++  K +  E+    LKE++ +L    E  ++L ++  D ++ QL+   +   +L+C
Sbjct: 577 GVSLLHKKSLEKEELCQRLKEQLDALE--KETASKLSEM--DSFNNQLKCGNMDDSVLQC 632

Query: 548 EELLLTAQLESIKRLISEKRDEVVYYDTYESMEAMLEKEEMAASAYLQREELQKLQQKAR 607
              LL+  L ++  L+ E R+    Y+T +     L K +      ++R+ L+ +Q+K  
Sbjct: 633 LLSLLSC-LNNLFLLLKELRET---YNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKL 688

Query: 608 QLEARRGRVSAKKSYLRNKKEICIAKHNEKIQQRTRIEDEYRTHHTVQLKREKLHDEEER 667
           + EA R     K++  +      + K  E+ Q+R +   E +T   +Q        EEER
Sbjct: 689 EDEAARKAKQGKENLWKEN----LRKEEEEKQKRLQ---EEKTQEKIQ--------EEER 733

Query: 668 KSAWVSQERQRTLDRLRTF-KQRYPGQVILKSTRLRLAHARRKGAASPVLQEDHCDSLPS 726
           K+    +++++  D L+   K+R    V++    L    AR          ++   +   
Sbjct: 734 KA---EEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARN--------HDEMSFNSGD 782

Query: 727 VLQVEEKTEEVGEGRVKRGPSQTTE---PQSLVQLEDTSLTQLEATSLPLSGVTSELPPT 783
           ++QV+EKT  VGE     G  Q      P + V+   +S  +       +S   + LPPT
Sbjct: 783 IIQVDEKT--VGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKA-----VSPKKALLPPT 835

Query: 784 ISLPLLNNNLEPCS 797
           +SL   + + EP S
Sbjct: 836 VSLSATSTSSEPLS 849



 Score = 37.0 bits (84), Expect = 0.091
 Identities = 30/130 (23%), Positives = 58/130 (44%), Gaps = 8/130 (6%)

Query: 576 YESMEAMLEKEEMAASAYLQREELQKLQQKARQLEARRGRVSAKKSYLRNKKEICIAKHN 635
           YE     LEK   A     QRE  +K Q++  + E ++  +  ++     KK++ + K  
Sbjct: 371 YERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEW----KKQLELEKRL 426

Query: 636 EKIQQRTRIEDEYRTHHTVQLKREKLHDEEERKSAWVSQERQRTLDRLRTFKQRYPGQVI 695
           EK ++  R  +E R     + +  K   E +R+  W    RQ  L++    K R   +++
Sbjct: 427 EKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQ----KNREQEEIV 482

Query: 696 LKSTRLRLAH 705
             +++ +  H
Sbjct: 483 RLNSKKKNLH 492


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.129    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,683,072
Number of Sequences: 37866
Number of extensions: 2659095
Number of successful extensions: 80161
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 994
Number of HSP's successfully gapped in prelim test: 1532
Number of HSP's that attempted gapping in prelim test: 30815
Number of HSP's gapped (non-prelim): 22956
length of query: 988
length of database: 18,247,518
effective HSP length: 112
effective length of query: 876
effective length of database: 14,006,526
effective search space: 12269716776
effective search space used: 12269716776
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.