Search of human proteins with 194578923

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194578923 sperm associated antigen 9 isoform 1 [Homo
sapiens]
         (1321 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]     2614   0.0  
gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]      2577   0.0  
gi|94557295 mitogen-activated protein kinase 8 interacting prote...  1387   0.0  
gi|94557297 mitogen-activated protein kinase 8 interacting prote...  1384   0.0  
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...   156   1e-37
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...   103   1e-21
gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like...   103   1e-21
gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapi...    99   2e-20
gi|56961680 coiled-coil domain containing 147 [Homo sapiens]           77   8e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     73   2e-12
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    68   7e-11
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    66   2e-10
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    66   2e-10
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    66   2e-10
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    66   2e-10
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    66   2e-10
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ...    66   2e-10
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo...    66   3e-10
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo...    66   3e-10
gi|156104908 myosin heavy chain 6 [Homo sapiens]                       65   3e-10
gi|64085252 hypothetical protein LOC145508 [Homo sapiens]              64   7e-10
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo...    64   1e-09
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    64   1e-09
gi|148746195 trichohyalin [Homo sapiens]                               62   3e-09
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]                    62   3e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    62   4e-09
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo...    62   4e-09
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]                   60   1e-08
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H...    60   2e-08
gi|38044112 restin isoform b [Homo sapiens]                            58   7e-08

>gi|194578923 sperm associated antigen 9 isoform 1 [Homo sapiens]
          Length = 1321

 Score = 2614 bits (6775), Expect = 0.0
 Identities = 1321/1321 (100%), Positives = 1321/1321 (100%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN
Sbjct: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR
Sbjct: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
            VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
Sbjct: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240
            QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP
Sbjct: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240

Query: 241  RSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG 300
            RSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG
Sbjct: 241  RSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG 300

Query: 301  FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 360
            FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY
Sbjct: 301  FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 360

Query: 361  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL 420
            KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL
Sbjct: 361  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL 420

Query: 421  LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA 480
            LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA
Sbjct: 421  LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA 480

Query: 481  EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 540
            EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE
Sbjct: 481  EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 540

Query: 541  NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP 600
            NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP
Sbjct: 541  NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP 600

Query: 601  GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG 660
            GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG
Sbjct: 601  GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG 660

Query: 661  QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD 720
            QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD
Sbjct: 661  QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD 720

Query: 721  TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN 780
            TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN
Sbjct: 721  TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN 780

Query: 781  ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG 840
            ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG
Sbjct: 781  ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG 840

Query: 841  GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG 900
            GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG
Sbjct: 841  GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG 900

Query: 901  SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE 960
            SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE
Sbjct: 901  SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE 960

Query: 961  EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG 1020
            EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG
Sbjct: 961  EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG 1020

Query: 1021 TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK 1080
            TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK
Sbjct: 1021 TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK 1080

Query: 1081 SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK 1140
            SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK
Sbjct: 1081 SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK 1140

Query: 1141 LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK 1200
            LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK
Sbjct: 1141 LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK 1200

Query: 1201 VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP 1260
            VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP
Sbjct: 1201 VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP 1260

Query: 1261 GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN 1320
            GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN
Sbjct: 1261 GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN 1320

Query: 1321 E 1321
            E
Sbjct: 1321 E 1321


>gi|27436920 sperm associated antigen 9 isoform 3 [Homo sapiens]
          Length = 1307

 Score = 2577 bits (6680), Expect = 0.0
 Identities = 1307/1321 (98%), Positives = 1307/1321 (98%), Gaps = 14/1321 (1%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN
Sbjct: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR
Sbjct: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
            VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH
Sbjct: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240
            QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP
Sbjct: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240

Query: 241  RSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG 300
            RSHTSLK              DELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG
Sbjct: 241  RSHTSLK--------------DELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEG 286

Query: 301  FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 360
            FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY
Sbjct: 287  FVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGY 346

Query: 361  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL 420
            KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL
Sbjct: 347  KGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQL 406

Query: 421  LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA 480
            LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA
Sbjct: 407  LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA 466

Query: 481  EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 540
            EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE
Sbjct: 467  EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRE 526

Query: 541  NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP 600
            NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP
Sbjct: 527  NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLP 586

Query: 601  GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG 660
            GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG
Sbjct: 587  GDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNG 646

Query: 661  QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD 720
            QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD
Sbjct: 647  QGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD 706

Query: 721  TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN 780
            TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN
Sbjct: 707  TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGN 766

Query: 781  ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG 840
            ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG
Sbjct: 767  ILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG 826

Query: 841  GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG 900
            GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG
Sbjct: 827  GITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSEVDENVPTAEEATEATEGNAG 886

Query: 901  SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE 960
            SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE
Sbjct: 887  SAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE 946

Query: 961  EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG 1020
            EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG
Sbjct: 947  EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADG 1006

Query: 1021 TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK 1080
            TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK
Sbjct: 1007 TLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEK 1066

Query: 1081 SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK 1140
            SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK
Sbjct: 1067 SFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGK 1126

Query: 1141 LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK 1200
            LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK
Sbjct: 1127 LGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK 1186

Query: 1201 VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP 1260
            VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP
Sbjct: 1187 VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEP 1246

Query: 1261 GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN 1320
            GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN
Sbjct: 1247 GSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGN 1306

Query: 1321 E 1321
            E
Sbjct: 1307 E 1307


>gi|94557295 mitogen-activated protein kinase 8 interacting protein 3
            isoform 2 [Homo sapiens]
          Length = 1330

 Score = 1387 bits (3589), Expect = 0.0
 Identities = 776/1366 (56%), Positives = 971/1366 (71%), Gaps = 86/1366 (6%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            M+   GVV  ++   SG+VMSERVSGLAGSIYREFERLI  YDEEVVKELMPLVV VLEN
Sbjct: 6    MDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLEN 65

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LDSV +++QEH+VELELLR+DNEQL+TQYEREKALR+ AEEKFIEFED+ EQEKK+LQ +
Sbjct: 66   LDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQ 125

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
            VE  E QTRQLELKAKNYADQISRLEERE+E+KKEYNALHQRHTEMI  Y+EH+ER+K+ 
Sbjct: 126  VEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ 185

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE-TPGSEQWKFQELSQ 239
            Q+ G+ Q ES+   R RKERP SL +FPL  G    T  AQ GG+  P  + W   +L Q
Sbjct: 186  QVGGNSQTESSLPGR-RKERPTSLNVFPLADG----TVRAQIGGKLVPAGDHWHLSDLGQ 240

Query: 240  PRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDT--PLKEE 297
             +S +S +       +    Q    +  S  G+K+ TP S+  S   T   ++  PL + 
Sbjct: 241  LQSSSSYQCPQDEMSESG--QSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDY 298

Query: 298  NEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDL 357
              G      A  K + S+++EVQV QE RNVS G   ++E S+VQ II+STPELDM  + 
Sbjct: 299  GVGSKNSKRAREKRD-SRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPET 357

Query: 358  SGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG----MGREVENL 413
               +  S+PT+GI NKAF  NT+SL+ ELS+AGS +IGDVDEGADLLG    MG+EV NL
Sbjct: 358  RLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSGMGKEVGNL 417

Query: 414  ILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEEL 473
            +LEN+QLLETKNALN+VKNDLIAKVD+L+ E++VL+GELEA KQAK+KLE + +ELEEEL
Sbjct: 418  LLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIKELEEEL 477

Query: 474  RKARAEAEDARQKAKDD----------DDSDIPTAQRKRFTRVEMARVLMERNQYKERLM 523
            ++ ++EA  AR++ K++          +   IP AQR+RFTRVEMARVLMERNQYKERLM
Sbjct: 478  KRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQYKERLM 537

Query: 524  ELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT--TKKPEPPVNLKYNAP 581
            ELQEAVRWTEMIRASRE+P++QEKK+S+IWQFFSRLFSSSS+    K+P P VN+ Y +P
Sbjct: 538  ELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVNIHYKSP 597

Query: 582  TSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDG 641
            T+      ++R+  +  +    S+  +F  ++ + + ++RREQKREQYRQV+ HV+ +DG
Sbjct: 598  TT--AGFSQRRNHAMCPISAG-SRPLEFFPDD-DCTSSARREQKREQYRQVREHVRNDDG 653

Query: 642  RVQAFGWSLPQKYKQVT--NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGK 699
            R+QA GWSLP KYKQ++   GQ + +MKN+PVPVY RPL EKD +MKLWCA GVNLSG +
Sbjct: 654  RLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGVNLSGWR 713

Query: 700  TRDGGSVVGASVFY-KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLV 758
              +  +  G      +D    D EG  +  ++ +S +K      ++ KEL   +  SS V
Sbjct: 714  PNEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEK------KKAKELPEMDATSSRV 767

Query: 759  WICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDLSESGQV 818
            WI TST + +KV+IIDA QPG ++D FTVCN+HVLCI+S+P A ++DYP GE   +S   
Sbjct: 768  WILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMFLDSD-- 825

Query: 819  DKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAE- 877
                      +      D +L GIT+VGC+        ++ S+ G +PV+DK     A  
Sbjct: 826  ---------VNPEDPGADGVLAGITLVGCATR-CNVPRSNCSSRGDTPVLDKGQGEVATI 875

Query: 878  -NSEVDENVPTAEEATEATE-GNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVY 935
             N +V+ +  T EEATEATE  + G +E      + G  TEHVFTDP         S   
Sbjct: 876  ANGKVNPSQST-EEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTP-----SSGP 929

Query: 936  QSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLH 995
            Q  +++    D  S  P E +   +     SS  PTMWLGAQNG LYVHS+VA W+KCLH
Sbjct: 930  QPGSENGPEPDSSSTRP-EPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVANWKKCLH 988

Query: 996  SIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTV 1055
            SIKLKDS+LS+VHVKG VLVALADGTLAIFHRG DGQWDLSNYHL+DLG PHHSIRCM V
Sbjct: 989  SIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHSIRCMAV 1048

Query: 1056 VHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLY 1115
            V+D+VWCGY+NK++V+QPK M+IEKSFDAHPR+ESQVRQLAW+GDGVWVSIRLDSTLRLY
Sbjct: 1049 VYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLDSTLRLY 1108

Query: 1116 HAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTET 1175
            HAHT+QHLQDVDIEPYVSKMLGTGKLGFSFVRITAL+V+ +RLWVGTGNGV+ISIPLTET
Sbjct: 1109 HAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVISIPLTET 1168

Query: 1176 -------------NKTSGVPGN--RPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFH 1220
                         NKTS   G   RPG +I VYGD++SD+    +FIPYCSMA AQLCFH
Sbjct: 1169 VVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSSDRAA-SSFIPYCSMAQAQLCFH 1227

Query: 1221 GHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQT---PLKSMLVISGGEG 1277
            GHRDAVKFFV+VPG V+   ++ +G+ L     GP    P S+     L+++LV+SGGEG
Sbjct: 1228 GHRDAVKFFVSVPGNVL---ATLNGSVLDSPAEGPGPAAPASEVEGQKLRNVLVLSGGEG 1284

Query: 1278 YIDFRMGD-EGGESEL-LGEDLPLEPSVTKAERSHLIVWQVMYGNE 1321
            YIDFR+GD E  E+E   G+   ++P ++KAERSH+IVWQV Y  E
Sbjct: 1285 YIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE 1330


>gi|94557297 mitogen-activated protein kinase 8 interacting protein 3
            isoform 1 [Homo sapiens]
          Length = 1336

 Score = 1384 bits (3583), Expect = 0.0
 Identities = 776/1372 (56%), Positives = 971/1372 (70%), Gaps = 92/1372 (6%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            M+   GVV  ++   SG+VMSERVSGLAGSIYREFERLI  YDEEVVKELMPLVV VLEN
Sbjct: 6    MDEGGGVVVYQDDYCSGSVMSERVSGLAGSIYREFERLIHCYDEEVVKELMPLVVNVLEN 65

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            LDSV +++QEH+VELELLR+DNEQL+TQYEREKALR+ AEEKFIEFED+ EQEKK+LQ +
Sbjct: 66   LDSVLSENQEHEVELELLREDNEQLLTQYEREKALRRQAEEKFIEFEDALEQEKKELQIQ 125

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
            VE  E QTRQLELKAKNYADQISRLEERE+E+KKEYNALHQRHTEMI  Y+EH+ER+K+ 
Sbjct: 126  VEHYEFQTRQLELKAKNYADQISRLEERESEMKKEYNALHQRHTEMIQTYVEHIERSKMQ 185

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE-TPGSEQWKFQELSQ 239
            Q+ G+ Q ES+   R RKERP SL +FPL  G    T  AQ GG+  P  + W   +L Q
Sbjct: 186  QVGGNSQTESSLPGR-RKERPTSLNVFPLADG----TVRAQIGGKLVPAGDHWHLSDLGQ 240

Query: 240  PRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDT--PLKEE 297
             +S +S +       +    Q    +  S  G+K+ TP S+  S   T   ++  PL + 
Sbjct: 241  LQSSSSYQCPQDEMSESG--QSSAAATPSTTGTKSNTPTSSVPSAAVTPLNESLQPLGDY 298

Query: 298  NEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDL 357
              G      A  K + S+++EVQV QE RNVS G   ++E S+VQ II+STPELDM  + 
Sbjct: 299  GVGSKNSKRAREKRD-SRNMEVQVTQEMRNVSIGMGSSDEWSDVQDIIDSTPELDMCPET 357

Query: 358  SGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG----------MG 407
               +  S+PT+GI NKAF  NT+SL+ ELS+AGS +IGDVDEGADLLG          MG
Sbjct: 358  RLDRTGSSPTQGIVNKAFGINTDSLYHELSTAGSEVIGDVDEGADLLGEFSVRDDFFGMG 417

Query: 408  REVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNR 467
            +EV NL+LEN+QLLETKNALN+VKNDLIAKVD+L+ E++VL+GELEA KQAK+KLE + +
Sbjct: 418  KEVGNLLLENSQLLETKNALNVVKNDLIAKVDQLSGEQEVLRGELEAAKQAKVKLENRIK 477

Query: 468  ELEEELRKARAEAEDARQKAKDD----------DDSDIPTAQRKRFTRVEMARVLMERNQ 517
            ELEEEL++ ++EA  AR++ K++          +   IP AQR+RFTRVEMARVLMERNQ
Sbjct: 478  ELEEELKRVKSEAIIARREPKEEAEDVSSYLCTESDKIPMAQRRRFTRVEMARVLMERNQ 537

Query: 518  YKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNT--TKKPEPPVN 575
            YKERLMELQEAVRWTEMIRASRE+P++QEKK+S+IWQFFSRLFSSSS+    K+P P VN
Sbjct: 538  YKERLMELQEAVRWTEMIRASREHPSVQEKKKSTIWQFFSRLFSSSSSPPPAKRPYPSVN 597

Query: 576  LKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAH 635
            + Y +PT+      ++R+  +  +    S+  +F  ++ + + ++RREQKREQYRQV+ H
Sbjct: 598  IHYKSPTT--AGFSQRRNHAMCPISAG-SRPLEFFPDD-DCTSSARREQKREQYRQVREH 653

Query: 636  VQKEDGRVQAFGWSLPQKYKQVT--NGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGV 693
            V+ +DGR+QA GWSLP KYKQ++   GQ + +MKN+PVPVY RPL EKD +MKLWCA GV
Sbjct: 654  VRNDDGRLQACGWSLPAKYKQLSPNGGQEDTRMKNVPVPVYCRPLVEKDPTMKLWCAAGV 713

Query: 694  NLSGGKTRDGGSVVGASVFY-KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQE 752
            NLSG +  +  +  G      +D    D EG  +  ++ +S +K      ++ KEL   +
Sbjct: 714  NLSGWRPNEDDAGNGVKPAPGRDPLTCDREGDGEPKSAHTSPEK------KKAKELPEMD 767

Query: 753  ELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDYPAGEDL 812
              SS VWI TST + +KV+IIDA QPG ++D FTVCN+HVLCI+S+P A ++DYP GE  
Sbjct: 768  ATSSRVWILTSTLTTSKVVIIDANQPGTVVDQFTVCNAHVLCISSIPAASDSDYPPGEMF 827

Query: 813  SESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPP 872
             +S             +      D +L GIT+VGC+        ++ S+ G +PV+DK  
Sbjct: 828  LDSD-----------VNPEDPGADGVLAGITLVGCATR-CNVPRSNCSSRGDTPVLDKGQ 875

Query: 873  EMEAE--NSEVDENVPTAEEATEATE-GNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPE 929
               A   N +V+ +  T EEATEATE  + G +E      + G  TEHVFTDP       
Sbjct: 876  GEVATIANGKVNPSQST-EEATEATEVPDPGPSEPETATLRPGPLTEHVFTDPAPTP--- 931

Query: 930  DLSPVYQSSNDSDAYKDQISVLPNEQDLVREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQ 989
              S   Q  +++    D  S  P E +   +     SS  PTMWLGAQNG LYVHS+VA 
Sbjct: 932  --SSGPQPGSENGPEPDSSSTRP-EPEPSGDPTGAGSSAAPTMWLGAQNGWLYVHSAVAN 988

Query: 990  WRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHS 1049
            W+KCLHSIKLKDS+LS+VHVKG VLVALADGTLAIFHRG DGQWDLSNYHL+DLG PHHS
Sbjct: 989  WKKCLHSIKLKDSVLSLVHVKGRVLVALADGTLAIFHRGEDGQWDLSNYHLMDLGHPHHS 1048

Query: 1050 IRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLD 1109
            IRCM VV+D+VWCGY+NK++V+QPK M+IEKSFDAHPR+ESQVRQLAW+GDGVWVSIRLD
Sbjct: 1049 IRCMAVVYDRVWCGYKNKVHVIQPKTMQIEKSFDAHPRRESQVRQLAWIGDGVWVSIRLD 1108

Query: 1110 STLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIIS 1169
            STLRLYHAHT+QHLQDVDIEPYVSKMLGTGKLGFSFVRITAL+V+ +RLWVGTGNGV+IS
Sbjct: 1109 STLRLYHAHTHQHLQDVDIEPYVSKMLGTGKLGFSFVRITALLVAGSRLWVGTGNGVVIS 1168

Query: 1170 IPLTET-------------NKTSGVPGN--RPGSVIRVYGDENSDKVTPGTFIPYCSMAH 1214
            IPLTET             NKTS   G   RPG +I VYGD++SD+    +FIPYCSMA 
Sbjct: 1169 IPLTETVVLHRGQLLGLRANKTSPTSGEGARPGGIIHVYGDDSSDRAA-SSFIPYCSMAQ 1227

Query: 1215 AQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQT---PLKSMLV 1271
            AQLCFHGHRDAVKFFV+VPG V+   ++ +G+ L     GP    P S+     L+++LV
Sbjct: 1228 AQLCFHGHRDAVKFFVSVPGNVL---ATLNGSVLDSPAEGPGPAAPASEVEGQKLRNVLV 1284

Query: 1272 ISGGEGYIDFRMGD-EGGESEL-LGEDLPLEPSVTKAERSHLIVWQVMYGNE 1321
            +SGGEGYIDFR+GD E  E+E   G+   ++P ++KAERSH+IVWQV Y  E
Sbjct: 1285 LSGGEGYIDFRIGDGEDDETEEGAGDMSQVKPVLSKAERSHIIVWQVSYTPE 1336


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score =  156 bits (394), Expect = 1e-37
 Identities = 158/616 (25%), Positives = 259/616 (42%), Gaps = 105/616 (17%)

Query: 748  LKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPGARETDY- 806
            L +  E S  VW+C S     +V ++      ++     VC++ +LCI +VPG +   + 
Sbjct: 1506 LNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHR 1565

Query: 807  ---------------PAGEDLSESGQVDKASLCGSMTSNSSAETDSLLG-GITVVGCSAE 850
                           PAG +L      D+ +   +          S+ G G+ +     E
Sbjct: 1566 EPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGE 1625

Query: 851  GVTGAATSP----STNGASPVMDKPPEMEAENSEV-----DENVPTAEEATEATEGNAGS 901
            G       P    S + +SP      + +A  S +     +E  P+++EAT  T  +   
Sbjct: 1626 GDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEE 1685

Query: 902  AEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDS---DAYKDQISVLPNEQDLV 958
             E    +  +G +       P G   P D   + +SS+ S    + +D +SV P      
Sbjct: 1686 QEPGF-LPLSGSFGPG---GPCGTS-PMDGRALRRSSHGSFTRGSLEDLLSVDP------ 1734

Query: 959  REEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKD--SILSIVHVKGIVLVA 1016
              EA + S     +WLG ++GC++V+ S    R   +S+KL+   S+  I+++   V V+
Sbjct: 1735 --EAYQSS-----VWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVS 1787

Query: 1017 LADGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAM 1076
            LA+G L ++ R     WD  N+  + LG     I  M  V  ++WCG +N++ V+ P  +
Sbjct: 1788 LANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTL 1847

Query: 1077 KIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKML 1136
            ++E  F         V  +     GVWV+++  + + LYH  T++ L +VD+ P V +ML
Sbjct: 1848 QLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRML 1907

Query: 1137 GTGKLGF-----SFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIR 1191
                        + +RITAL+V    LWVGT  GV++++P +            PG+V  
Sbjct: 1908 AGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTS------------PGTVS- 1954

Query: 1192 VYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAV----------PGQVISPQS 1241
                            P   ++   L   GH   V+F  AV          P     P +
Sbjct: 1955 ---------------CPRAPLSPTGLG-QGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDT 1998

Query: 1242 SSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGG-ESELLGEDLPLE 1300
                      +  P  + P    P   MLVISGG+GY DFR+   GG  SE +G D    
Sbjct: 1999 GPEKLPSLEHRDSPWHRGPAPARP--KMLVISGGDGYEDFRLSSGGGSSSETVGRD---- 2052

Query: 1301 PSVTKAERSHLIVWQV 1316
                    +HL++W+V
Sbjct: 2053 -----DSTNHLLLWRV 2063


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 1 [Homo sapiens]
          Length = 1279

 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/224 (29%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 962  AQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK--DSILSIVHVKGIVLVALAD 1019
            A   +++ PT+ LG Q+G + ++SSV    +CL S +      +L + H    +L  L D
Sbjct: 884  ADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQD 943

Query: 1020 GTLAIFHRGVDGQ-WDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1078
            GTLA + R   G  WDL +  +     P   +R +  + D VW     ++ V++   ++ 
Sbjct: 944  GTLAAYPRTSGGVLWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQP 1002

Query: 1079 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1138
            ++SF+AH  +   V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L  
Sbjct: 1003 QQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP- 1061

Query: 1139 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVP 1182
               G   + +T+L++    LWVGT  GVI+ +P+    +  G+P
Sbjct: 1062 ---GQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP---RLEGIP 1099


>gi|74136547 Rho guanine nucleotide exchange factor (GEF) 10-like
            isoform 2 [Homo sapiens]
          Length = 1240

 Score =  103 bits (256), Expect = 1e-21
 Identities = 65/224 (29%), Positives = 117/224 (52%), Gaps = 11/224 (4%)

Query: 962  AQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLK--DSILSIVHVKGIVLVALAD 1019
            A   +++ PT+ LG Q+G + ++SSV    +CL S +      +L + H    +L  L D
Sbjct: 845  ADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQD 904

Query: 1020 GTLAIFHRGVDGQ-WDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1078
            GTLA + R   G  WDL +  +     P   +R +  + D VW     ++ V++   ++ 
Sbjct: 905  GTLAAYPRTSGGVLWDLESPPVCLTVGPG-PVRTLLSLEDAVWASCGPRVTVLEATTLQP 963

Query: 1079 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1138
            ++SF+AH  +   V  +   G GVW++    +++RL+H  T +HLQ+++I    + +L  
Sbjct: 964  QQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLP- 1022

Query: 1139 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVP 1182
               G   + +T+L++    LWVGT  GVI+ +P+    +  G+P
Sbjct: 1023 ---GQKHLCVTSLLICQGLLWVGTDQGVIVLLPVP---RLEGIP 1060


>gi|62548864 Rho guanine nucleotide exchange factor 10 [Homo sapiens]
          Length = 1344

 Score = 99.4 bits (246), Expect = 2e-20
 Identities = 67/272 (24%), Positives = 124/272 (45%), Gaps = 47/272 (17%)

Query: 966  SSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKL-------KDSILSIVHVKGIVLVALA 1018
            +S +PT+ +G + G + ++ S    +K    ++L       K +++S+      +   L 
Sbjct: 960  ASDVPTICVGTEEGSISIYKSSQGSKK----VRLQHFFTPEKSTVMSLACTSQSLYAGLV 1015

Query: 1019 DGTLAIFHRGVDGQWDLSNYHLLDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKI 1078
            +G +A + R  DG WD     ++ LG     +R + ++ D +W     +++++  +   +
Sbjct: 1016 NGAVASYARAPDGSWDSEPQKVIKLGVL--PVRSLLMMEDTLWAASGGQVFIISVETHAV 1073

Query: 1079 EKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGT 1138
            E   +AH  +   +  +A  G G+W++    STLRL+H  T +HLQD++I   V  ML  
Sbjct: 1074 EGQLEAHQEEGMVISHMAVSGVGIWIAFTSGSTLRLFHTETLKHLQDINIATPVHNMLP- 1132

Query: 1139 GKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENS 1198
               G   + +T+L+V    L VGT  GV++++P+    +  G+P                
Sbjct: 1133 ---GHQRLSVTSLLVCHGLLMVGTSLGVLVALPVP---RLQGIP---------------- 1170

Query: 1199 DKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFV 1230
             KVT              + +H H   VKF V
Sbjct: 1171 -KVT----------GRGMVSYHAHNSPVKFIV 1191


>gi|56961680 coiled-coil domain containing 147 [Homo sapiens]
          Length = 872

 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 113/539 (20%), Positives = 238/539 (44%), Gaps = 56/539 (10%)

Query: 22  ERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDD 81
           E+ SGL+   +     L+ R+ EEV KE   L+  V++  +S+ AQ  E Q E E  +++
Sbjct: 135 EQGSGLSMDQHSNIRDLL-RFKEEVTKERDQLLSEVVKLRESL-AQTTEQQQETERSKEE 192

Query: 82  NEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQ 141
            E  I+Q+++E   R++   +    ++  E+E K +Q  ++S +++ + L+   +   ++
Sbjct: 193 AEHAISQFQQEIQQRQNEASREFRKKEKLEKELKQIQADMDSRQTEIKALQQYVQKSKEE 252

Query: 142 ISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERP 201
           + +LE++     KE   L++R  + +  +   +   KL Q       E+  HS + ++  
Sbjct: 253 LQKLEQQ----LKEQKILNERAAKELEQF--QMRNAKLQQ-------ENEQHSLVCEQ-- 297

Query: 202 ISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ------ELSQPRSHTSLKVSNSPEPQ 255
                        L   + QK  E    E+   Q      +L++ R     K+ ++ + +
Sbjct: 298 -------------LSQENQQKALELKAKEEEVHQMRLDIGKLNKIREQIHKKLHHTEDQK 344

Query: 256 KAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEE---NEGFVKVTDAPNKSE 312
             VEQ  E       G +    AS   +++     D  L+E    N+  +K  +A  K  
Sbjct: 345 AEVEQHKETLKNQIVGLEREVEASKKQAELDRKAMDELLRERDILNKNMLKAVNATQKQT 404

Query: 313 ISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIEN 372
                 V++ ++ +    G  +N  K E Q   +    L+ ++D    + S    K + N
Sbjct: 405 DL----VKLHEQAKRNLEGEIQN-YKDEAQKQRKIIFHLEKERDRYINQASDLTQKVLMN 459

Query: 373 KAFDRNTES-LFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVK 431
               +  E+ +F+         I  + +  +L    R   NL  +N  L+E ++ +  +K
Sbjct: 460 MEDIKVRETQIFDYRKKIAESEI-KLKQQQNLYEAVRSDRNLYSKN--LVEAQDEITDMK 516

Query: 432 NDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD 491
             L   + ++    D L+ ++ A + A +KL  + + +E+E    +AE +  RQ+A +  
Sbjct: 517 RKLKIMIHQV----DELKEDISAKESALVKLHLEQQRIEKEKETLKAELQKLRQQALETK 572

Query: 492 D-SDIPTAQRKRFTRVEMARVLMERNQYKERLMEL--QEAVRWTEMIRASRENPAMQEK 547
              +   A+ ++  R+ +A    ER + K+ L ++  +  +  ++++R + E   + EK
Sbjct: 573 HFIEKQEAEERKLLRI-IAEADGERLRQKKELDQVISERDILGSQLVRRNDELALLYEK 630



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 27/116 (23%), Positives = 51/116 (43%), Gaps = 8/116 (6%)

Query: 54  VVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRK--HAEEKFIEFEDSQE 111
           ++  +  L        E  VE ELL  + E+L  + +   A +    A E+   +  +  
Sbjct: 726 LIQKIHTLQKRLISKTEEVVEKELLLQEKEKLYMELKHVLARQPGPEAAEQLKLYRRTLH 785

Query: 112 QEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMI 167
            +K+ L+     L S+    E+++K Y  ++ +L      LKK+Y  L Q+  E +
Sbjct: 786 DKKQQLKV----LSSELNMYEVQSKEYKYEVEKLTNELQNLKKKY--LAQKRKEQL 835


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 145/666 (21%), Positives = 276/666 (41%), Gaps = 97/666 (14%)

Query: 32   YREFERLIGRYDEEVVKELMPL--VVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQY 89
            + E ER+     ++V K  + L  V  +L   DS  ++  +    LE    D ++L+ + 
Sbjct: 1261 FNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEE 1320

Query: 90   EREKA-----LRKHAEEK--FIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQI 142
             R+K      L++  +EK  F E  + +E+ K +L+ ++ +L +Q   ++ K ++    +
Sbjct: 1321 NRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCL 1380

Query: 143  SRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH-QLSGSDQLESTAHSRI----- 196
               EE + +L+K+   L QRH E +  Y + LE+TK   Q    D L    H R      
Sbjct: 1381 ETAEEVKRKLQKDLEGLSQRHEEKVAAY-DKLEKTKTRLQQELDDLLVDLDHQRQSACNL 1439

Query: 197  -RKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQ 255
             +K++            D LL  +     +    E+ + +  ++ +   +L ++ + E  
Sbjct: 1440 EKKQKKF----------DQLLAEEKTISAKY-AEERDRAEAEAREKETKALSLARALE-- 1486

Query: 256  KAVEQEDELSDVSQGGSKATTPASTANSDVATIPTD----------------TPLKEENE 299
            +A+EQ+ EL  +++          ++  DV     +                T L+E  +
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546

Query: 300  GFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSE--VQAIIESTPELDMDKD- 356
                  DA  + E++  ++   AQ  R++     ++EEK +  V+ + E   EL+ ++  
Sbjct: 1547 ELQATEDAKLRLEVN--LQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604

Query: 357  ----LSGYKGSSTPTKGIE------NKAFDRNTESLFEELSSAGSGLIGDVDEGA----D 402
                ++  K      K +E      NK  D   + L  +L +     + ++D+      +
Sbjct: 1605 RSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQL-RKLQAQMKDCMRELDDTRASREE 1663

Query: 403  LLGMGREVENLI----LENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 458
            +L   +E E  +     E  QL E   A    K     + DEL  E     G+     + 
Sbjct: 1664 ILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEE 1723

Query: 459  KLKLEEKNRELEEELRKARAEAE---DARQKAK---DDDDSDIPTAQRKRFTRVEMARVL 512
            K +LE +  +LEEEL + +   E   D  +KA    D  ++D+   +R    + E AR  
Sbjct: 1724 KRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL-NLERSHAQKNENARQQ 1782

Query: 513  MERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEP 572
            +ER Q KE  ++LQE +  T   +      A++ K         ++L     N TK+ + 
Sbjct: 1783 LER-QNKELKVKLQE-MEGTVKSKYKASITALEAK--------IAQLEEQLDNETKERQ- 1831

Query: 573  PVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQV 632
                   A    V  + KK    L Q+  ++  A  +  +  +AS  +R +Q + Q  + 
Sbjct: 1832 -------AACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKAS--TRLKQLKRQLEEA 1882

Query: 633  KAHVQK 638
            +   Q+
Sbjct: 1883 EEEAQR 1888



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 121/607 (19%), Positives = 235/607 (38%), Gaps = 112/607 (18%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R +EE          ++EL   +  + E+L+S  A       Q ++   ELE 
Sbjct: 1084 ELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEA 1143

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKN 137
            L+ + E  +     ++ LR   E++    + + E+E K  + +++ +  +  Q     + 
Sbjct: 1144 LKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ---AVEE 1200

Query: 138  YADQISRLEEREAELKKEYNALHQRHTEMIHNY---------MEHLERTKLHQLSGSDQL 188
             A+Q+ + +  +A L+K    L     E+ +            EH +R K+       Q+
Sbjct: 1201 LAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEH-KRKKVEAQLQELQV 1259

Query: 189  ESTAHSRIRKERPISLGIFPLPAGD--GLLTPDAQKGGETP------GSEQWKFQELSQP 240
            +     R+R E    +    +   +  GLL+    K  +         S+    QEL Q 
Sbjct: 1260 KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQE 1319

Query: 241  RSHTSLKVSNSPEPQKAVEQE-----DELSDVSQGGSKATTPASTANSDVATIPTDTPLK 295
             +   L +S      K VE E     ++L +  +         +T ++ VA    D   K
Sbjct: 1320 ENRQKLSLSTK---LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVA----DMKKK 1372

Query: 296  EENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD-- 352
             E+      T    K ++ K +E    +    V+      + K+ +Q  ++    +LD  
Sbjct: 1373 MEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQ 1432

Query: 353  ------MDKDLSGYKGSSTPTKGIENKAFDRNTESLFE------ELSSAGSGLIGDVDEG 400
                  ++K    +       K I  K  +    +  E      +  S    L   +++ 
Sbjct: 1433 RQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQK 1492

Query: 401  ADLLGMGR----EVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVK 456
            A+L  + +    E+E+L+     + ++ + L   K  L  +V+E+  + + L+ EL+A +
Sbjct: 1493 AELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATE 1552

Query: 457  QAKLKL----------------------EEKNRELEEELRKARAEAEDARQKAK------ 488
             AKL+L                      EEK ++L  ++R+  AE ED R++        
Sbjct: 1553 DAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAAR 1612

Query: 489  -------DDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASREN 541
                    D ++ I +A + R   ++  R L  + Q K+ + EL +        RASRE 
Sbjct: 1613 KKLEMDLKDLEAHIDSANKNRDEAIKQLRKL--QAQMKDCMRELDDT-------RASREE 1663

Query: 542  PAMQEKK 548
               Q K+
Sbjct: 1664 ILAQAKE 1670



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 120/605 (19%), Positives = 250/605 (41%), Gaps = 101/605 (16%)

Query: 68   DQEHQVELELLRDDNEQLITQYEREKA-LRKHAEEKFIEFEDSQEQEKKDLQTRVESLES 126
            D+  ++++EL  D+   L++Q + + + L K       + +D+QE  +++ + ++ SL +
Sbjct: 1273 DKVTKLQVEL--DNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKL-SLST 1329

Query: 127  QTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM-------------------- 166
            + +Q+E +  ++ +Q+   EE +  L+K+   LH +  +M                    
Sbjct: 1330 KLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRK 1389

Query: 167  IHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGE- 225
            +   +E L +    +++  D+LE T  +R+++E             D L+  D Q+    
Sbjct: 1390 LQKDLEGLSQRHEEKVAAYDKLEKT-KTRLQQE-----------LDDLLVDLDHQRQSAC 1437

Query: 226  TPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDV 285
                +Q KF +L       S K +   +  +A  +E E   +S   ++A   A    +++
Sbjct: 1438 NLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSL--ARALEEAMEQKAEL 1495

Query: 286  ATIPTDTPLKEENEGFVKVTDAPNKS--EISKHIEVQVAQETRNVSTGSAENEEKSEVQA 343
              +  +   + E E  +   D   KS  E+ K  +  + Q+   + T   E E+  E+QA
Sbjct: 1496 ERL--NKQFRTEMEDLMSSKDDVGKSVHELEKS-KRALEQQVEEMKTQLEELED--ELQA 1550

Query: 344  IIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADL 403
              ++  +L ++ +L   K             F+R+ +   E+       L+  V E    
Sbjct: 1551 TEDA--KLRLEVNLQAMKAQ-----------FERDLQGRDEQSEEKKKQLVRQVRE---- 1593

Query: 404  LGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLE 463
              M  E+E+   + +  +  +  L +   DL A +D     +D      EA+KQ + KL+
Sbjct: 1594 --MEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRD------EAIKQLR-KLQ 1644

Query: 464  EKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLM 523
             + ++   EL   RA  E+   +AK+++             + E+A     + Q ++   
Sbjct: 1645 AQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERD 1704

Query: 524  ELQEAVRWTEMIRASRENP-AMQEKKR--SSIWQFFSRLFSSSSNTTKKPEPPVNLKYNA 580
            EL +     E+  +S +   A++EK+R  + I Q    L     N               
Sbjct: 1705 ELAD-----EIANSSGKGALALEEKRRLEARIAQLEEELEEEQGN--------------- 1744

Query: 581  PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED 640
             T  +   +KK +  + Q+  D +     L         + R+Q   Q +++K  +Q+ +
Sbjct: 1745 -TELINDRLKKANLQIDQINTDLN-----LERSHAQKNENARQQLERQNKELKVKLQEME 1798

Query: 641  GRVQA 645
            G V++
Sbjct: 1799 GTVKS 1803



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 104/518 (20%), Positives = 211/518 (40%), Gaps = 48/518 (9%)

Query: 43   DEEVVKELMPLV---VAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHA 99
            +EE  K L  L     A++ +L+    ++++ + ELE  R   E   T    + A     
Sbjct: 1011 EEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIA---EL 1067

Query: 100  EEKFIEFEDSQEQEKKDLQTRVESLESQTRQLEL---KAKNYADQISRLEEREAELKKEY 156
            + +  E +    +++++LQ  +  +E +  Q  +   K +    QIS L+E   +L+ E 
Sbjct: 1068 QAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQE---DLESE- 1123

Query: 157  NALHQRHTEMIHNYMEHLERTKLHQLSGSDQLEST-AHSRIRKERPISLGIFPLPAGDGL 215
             A   +  +   +  E LE  K       D L+ST A   +R +R   + I      +  
Sbjct: 1124 RASRNKAEKQKRDLGEELEALKTEL---EDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180

Query: 216  LTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQE-----DELSDVSQG 270
             T +AQ   E         +EL++    T    +N  + ++ +E E     +E+  + QG
Sbjct: 1181 KTHEAQI-QEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQG 1239

Query: 271  GSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNK-SEISKHIEVQVAQETRNVS 329
               +        + +  +       + NEG    T+  +K +++   ++      +++ S
Sbjct: 1240 KGDSEHKRKKVEAQLQELQV-----KFNEGERVRTELADKVTKLQVELDNVTGLLSQSDS 1294

Query: 330  TGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIEN------------KAFDR 377
              S   ++ S +++ ++ T EL + ++       ST  K +E+            +    
Sbjct: 1295 KSSKLTKDFSALESQLQDTQEL-LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353

Query: 378  NTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAK 437
            N E     L +  + +   +++    L    EV+  + ++ + L  ++   +   D + K
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEK 1413

Query: 438  V-DELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIP 496
                L  E D L  +L+  +Q+   LE+K ++ ++ L    AE +    K  ++ D    
Sbjct: 1414 TKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLL----AEEKTISAKYAEERDRAEA 1469

Query: 497  TAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEM 534
             A+ K    + +AR L E  + K  L  L +  R TEM
Sbjct: 1470 EAREKETKALSLARALEEAMEQKAELERLNKQFR-TEM 1506



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 110/512 (21%), Positives = 210/512 (41%), Gaps = 90/512 (17%)

Query: 288  IPTDTPLKEENEGFVKVTDAPNK-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIE 346
            + T+  LK+  E  + + D   K ++  K +E ++A+ T N++    E EEKS+  A ++
Sbjct: 967  VTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLT----EEEEKSKSLAKLK 1022

Query: 347  STPEL---DMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADL 403
            +  E    D+++ L                   R  E   +EL      L GD  + +D 
Sbjct: 1023 NKHEAMITDLEERL-------------------RREEKQRQELEKTRRKLEGDSTDLSDQ 1063

Query: 404  LGMGREVENLILE-NTQLLETKNALNIV----------KNDLIAKVDELTCEKDVLQGEL 452
            +    E++  I E   QL + +  L             KN  + K+ EL  +   LQ +L
Sbjct: 1064 IA---ELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDL 1120

Query: 453  EAVKQAKLKLEEKNRELEEELRKARAEAED------ARQ--KAKDDDDSDIPTAQRKRFT 504
            E+ + ++ K E++ R+L EEL   + E ED      A+Q  ++K + + +I     +   
Sbjct: 1121 ESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEA 1180

Query: 505  RVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQ-EKKRSSIWQFFSRLF--- 560
            +   A++   R ++ + + EL E +  T+ ++A+ E      E +R  +      L    
Sbjct: 1181 KTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGK 1240

Query: 561  SSSSNTTKKPE---PPVNLKYN---APTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEET 614
              S +  KK E     + +K+N      + +   V K    L  + G  S++      ++
Sbjct: 1241 GDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQS------DS 1294

Query: 615  EASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQG---------ENK 665
            ++S  ++     E   Q    + +E+ R +    SL  K KQV + +          E  
Sbjct: 1295 KSSKLTKDFSALESQLQDTQELLQEENRQKL---SLSTKLKQVEDEKNSFREQLEEEEEA 1351

Query: 666  MKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSK 725
              NL   +        D   K+  +VG   +  + +            KD+ GL ++  +
Sbjct: 1352 KHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVK--------RKLQKDLEGL-SQRHE 1402

Query: 726  QRSASQSSLDK----LDQELKEQQKELKNQEE 753
            ++ A+   L+K    L QEL +   +L +Q +
Sbjct: 1403 EKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQ 1434



 Score = 43.9 bits (102), Expect = 0.001
 Identities = 124/608 (20%), Positives = 243/608 (39%), Gaps = 57/608 (9%)

Query: 39   IGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKH 98
            + R +EE++ +   LV    + L +     +   ++ +L+ +   QL  Q + E  L   
Sbjct: 840  VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAE-KLQLQEQLQAETELCAE 898

Query: 99   AEE---KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKE 155
            AEE   +    +   E+   DL+ RVE  E + + L+ + K     I  LEE   +L++E
Sbjct: 899  AEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEE---QLEEE 955

Query: 156  YNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR-------------IRKERPI 202
             +A  +   E +    + L++ +  Q+   DQ    A  +             + +E   
Sbjct: 956  ESARQKLQLEKVTTEAK-LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEK 1014

Query: 203  SLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQED 262
            S  +  L      +  D +   E    E+ + QEL + R    L+  ++    +  E + 
Sbjct: 1015 SKSLAKLKNKHEAMITDLE---ERLRREEKQRQELEKTR--RKLEGDSTDLSDQIAELQA 1069

Query: 263  ELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVA 322
            +++++    +K       A + V     +    ++N    K+ +   +S+IS   E+Q  
Sbjct: 1070 QIAELKMQLAKKEEELQAALARV-----EEEAAQKNMALKKIREL--ESQIS---ELQED 1119

Query: 323  QETRNVSTGSAENEEK---SEVQAI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRN 378
             E+   S   AE +++    E++A+  E    LD        +        I  K  +  
Sbjct: 1120 LESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEE 1179

Query: 379  TESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNA--LNIVKNDLIA 436
             ++   ++          V+E A+ L   + V+  + +  Q LE +     N VK  L  
Sbjct: 1180 AKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQG 1239

Query: 437  KVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIP 496
            K D     K V + +L+ ++    + E    EL +++ K + E ++        D     
Sbjct: 1240 KGDSEHKRKKV-EAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKS-- 1296

Query: 497  TAQRKRFTRVE-----MARVLMERNQYKERLMELQEAVRWTEMIRAS-RENPAMQEKKRS 550
            +   K F+ +E        +L E N+ K   + L   ++  E  + S RE    +E+ + 
Sbjct: 1297 SKLTKDFSALESQLQDTQELLQEENRQK---LSLSTKLKQVEDEKNSFREQLEEEEEAKH 1353

Query: 551  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 610
            ++ +  + L +  ++  KK E  V     A    V   ++K    LSQ   +K  A+D L
Sbjct: 1354 NLEKQIATLHAQVADMKKKMEDSVGCLETA--EEVKRKLQKDLEGLSQRHEEKVAAYDKL 1411

Query: 611  SEETEASL 618
             E+T+  L
Sbjct: 1412 -EKTKTRL 1418



 Score = 33.5 bits (75), Expect = 1.4
 Identities = 52/240 (21%), Positives = 104/240 (43%), Gaps = 25/240 (10%)

Query: 419  QLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA 478
            +L   K  L  + +DL A+V+E       LQ E + ++Q   +LEE+  E E   +K + 
Sbjct: 905  RLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQKLQL 964

Query: 479  E--AEDARQKAKDD-----DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRW 531
            E    +A+ K  ++     +D +   A+ K+     +A       + +E+   L +    
Sbjct: 965  EKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNK 1024

Query: 532  TE-MIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKK--------PEPPVNL-----K 577
             E MI    E    +EK+R  + +   +L   S++ + +         E  + L     +
Sbjct: 1025 HEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKKEEE 1084

Query: 578  YNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASR---REQKREQYRQVKA 634
              A  + V     +++  L ++   +S+  + L E+ E+  ASR    +QKR+   +++A
Sbjct: 1085 LQAALARVEEEAAQKNMALKKIRELESQISE-LQEDLESERASRNKAEKQKRDLGEELEA 1143



 Score = 32.3 bits (72), Expect = 3.1
 Identities = 82/459 (17%), Positives = 178/459 (38%), Gaps = 64/459 (13%)

Query: 34   EFERLIGRYDE--EVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYER 91
            E E L+   D+  + V EL     A+ + ++ +  Q +E + EL+   D   +L    + 
Sbjct: 1505 EMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564

Query: 92   EKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAE 151
             KA      E+ ++  D Q +EKK      + L  Q R++E + ++   Q S       +
Sbjct: 1565 MKA----QFERDLQGRDEQSEEKK------KQLVRQVREMEAELEDERKQRSMAVAARKK 1614

Query: 152  LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPA 211
            L+ +   L         N  E +++ +  Q    D +     +R  +E  ++        
Sbjct: 1615 LEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQA------ 1668

Query: 212  GDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGG 271
                   + +K  ++  +E  + QE        + + +     Q+  E  DE+++ S  G
Sbjct: 1669 ------KENEKKLKSMEAEMIQLQE-----ELAAAERAKRQAQQERDELADEIANSSGKG 1717

Query: 272  SKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTG 331
            + A        + +A +  +  L+EE      + D   K+ +      Q+ Q   ++   
Sbjct: 1718 ALALEEKRRLEARIAQLEEE--LEEEQGNTELINDRLKKANL------QIDQINTDL--- 1766

Query: 332  SAENEEKSEVQAIIESTPELD-MDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAG 390
               N E+S  Q    +  +L+  +K+L            ++ +  +   +S ++   +A 
Sbjct: 1767 ---NLERSHAQKNENARQQLERQNKELK-----------VKLQEMEGTVKSKYKASITAL 1812

Query: 391  SGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQG 450
               I  ++E  D      E +       Q+  T+  L     D++ +VD+     +  + 
Sbjct: 1813 EAKIAQLEEQLD-----NETKERQAACKQVRRTEKKLK----DVLLQVDDERRNAEQYKD 1863

Query: 451  ELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKD 489
            + +       +L+ +  E EEE ++A A     +++ +D
Sbjct: 1864 QADKASTRLKQLKRQLEEAEEEAQRANASRRKLQRELED 1902


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 67.8 bits (164), Expect = 7e-11
 Identities = 146/727 (20%), Positives = 287/727 (39%), Gaps = 97/727 (13%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFI----EFEDSQEQEKK------DLQT 119
            E + E+  ++++ ++   +  + +A RK  EEK +    E  D Q Q +       D + 
Sbjct: 847  ETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEE 906

Query: 120  RVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKL 179
            R E L     QLE K K   ++    EE  AEL  +   L    +E+  + ++ LE T  
Sbjct: 907  RCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKD-IDDLELTLA 965

Query: 180  HQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQ 239
                     E+   +   +   +   I  L      L    Q+  +   +E+ K   L++
Sbjct: 966  KVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTK 1025

Query: 240  PRSHTSLKVSN---SPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKE 296
             ++    +V +   S E +K +  + E +     G       ST + +      D  L++
Sbjct: 1026 AKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEK 1085

Query: 297  ENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKD 356
            +     ++++  +K E  + +E+Q+ ++ +             E+QA IE     ++ ++
Sbjct: 1086 KE---FEISNLISKIEDEQAVEIQLQKKIK-------------ELQARIE-----ELGEE 1124

Query: 357  LSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVD----EGADLLGMGREVEN 412
            +   + S    +  +     R  E + E L  AG      V+      A+   + R++E 
Sbjct: 1125 IEAERASRAKAEK-QRSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEE 1183

Query: 413  LILENTQL---LETKNA------------LNIVKNDLIAKVDELTCEKDVLQGELEAVKQ 457
              L++  +   L  K+A            L  VK  L  +  EL  E D L    EA+ +
Sbjct: 1184 ATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISK 1243

Query: 458  AKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRV--EMARVLMER 515
            AK  LE+  R LE+++ + + + E+ ++   D       TAQR R      E +R L E+
Sbjct: 1244 AKGNLEKMCRSLEDQVSELKTKEEEQQRLIND------LTAQRARLQTEAGEYSRQLDEK 1297

Query: 516  NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVN 575
            +    +L   ++A   T+ I   +     + K ++++               ++ E    
Sbjct: 1298 DALVSQLSRSKQAS--TQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQE 1355

Query: 576  LKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAH 635
             K     + +  ++ K +S ++Q              + E     R E+  E  +++   
Sbjct: 1356 GK-----AELQRALSKANSEVAQ-----------WRTKYETDAIQRTEELEEAKKKLAQR 1399

Query: 636  VQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPV-----YLRPLDEKDTSMKLWCA 690
            +Q+ +  V+A         K  T  + +N++++L + V         LD+K  +      
Sbjct: 1400 LQEAEEHVEAVNAKCASLEK--TKQRLQNEVEDLMLDVERSNAACAALDKKQRNF----- 1452

Query: 691  VGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKN 750
                LS  K +   +        K+   L TE  K ++  + SLD+L + L+ + K L  
Sbjct: 1453 -DKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQL-ETLRRENKNL-- 1508

Query: 751  QEELSSL 757
            Q+E+S L
Sbjct: 1509 QQEISDL 1515



 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 120/636 (18%), Positives = 251/636 (39%), Gaps = 56/636 (8%)

Query: 48   KELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLIT--------------QYEREK 93
            KEL   +V +L+  + +  Q Q     L    +  EQLI               + E E+
Sbjct: 874  KELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEE 933

Query: 94   ALRKHAEEKFIEFEDSQEQEKKD---LQTRVESLESQTRQLELKAKNYADQISRLEEREA 150
             +      K  + ED   + KKD   L+  +  +E +    E K KN  ++++ L+E  A
Sbjct: 934  EINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIA 993

Query: 151  ELKKEYNALHQRHTEMIHNYMEHLER--------TKLHQ----LSGSDQLESTAHSRIRK 198
            +L KE  AL + H + + +     ++        TKL Q    L GS + E      + +
Sbjct: 994  KLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLER 1053

Query: 199  ERPISLGIFPLPAGDGL-LTPDAQKGGETPGSEQWKFQEL-SQPRSHTSLKVSNSPEPQK 256
             +    G   L     + +  D Q+  E    ++++   L S+     ++++    + ++
Sbjct: 1054 AKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKE 1113

Query: 257  AVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKS-EISK 315
               + +EL +  +    +   A    SD++       L+E +E   +   A +   E++K
Sbjct: 1114 LQARIEELGEEIEAERASRAKAEKQRSDLSR-----ELEEISERLEEAGGATSAQVELNK 1168

Query: 316  HIEVQVAQETRNVSTGSAENE------EKSEVQAIIESTPELDMDKDLSGYKGSSTPTKG 369
              E +  +  R++   + ++E       K    ++ E   ++D  + +            
Sbjct: 1169 KREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELK 1228

Query: 370  IENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNI 429
            +E      N E++ +   +         D+ ++L     E + LI     L   +  L  
Sbjct: 1229 METDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLI---NDLTAQRARLQT 1285

Query: 430  VKNDLIAKVDELTCEKDVLQGELEAVKQAKL-KLEEKNRELEEELRKARAEAEDARQKAK 488
               +   ++DE    KD L  +L   KQA   ++EE   +LEEE  KA+     A Q ++
Sbjct: 1286 EAGEYSRQLDE----KDALVSQLSRSKQASTQQIEELKHQLEEE-TKAKNALAHALQSSR 1340

Query: 489  DDDDSDIPTAQRKRFTRVEMARVLMERNQ--YKERLMELQEAVRWTEMIRASRENPAMQE 546
             D D      + ++  + E+ R L + N    + R     +A++ TE +  +++  A + 
Sbjct: 1341 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1400

Query: 547  KKRSSIWQFFSRLFSSSSNTTKKPEPPV-NLKYNAPTSHVT-PSVKKRSSTLSQLPGDKS 604
            ++     +  +   +S   T ++ +  V +L  +   S+    ++ K+     ++  +  
Sbjct: 1401 QEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWK 1460

Query: 605  KAFDFLSEETEASLASRREQKREQYRQVKAHVQKED 640
            + ++    E EAS    R    E ++    + +  D
Sbjct: 1461 QKYEETQAELEASQKESRSLSTELFKVKNVYEESLD 1496



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 102/518 (19%), Positives = 189/518 (36%), Gaps = 100/518 (19%)

Query: 68   DQEHQVELELLRDDNEQLITQYEREKAL--RKHAE---------------EKFIEFEDSQ 110
            +++ + E + LR D E+   Q+E   A   +KHA+               ++ +E E S+
Sbjct: 1167 NKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSE 1226

Query: 111  -EQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHN 169
             + E  DL +  E++      LE   ++  DQ+S L+ +E E ++  N L  +   +   
Sbjct: 1227 LKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARL--- 1283

Query: 170  YMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTP-DAQKGGETPG 228
                             Q E+  +SR   E+            D L++     K   T  
Sbjct: 1284 -----------------QTEAGEYSRQLDEK------------DALVSQLSRSKQASTQQ 1314

Query: 229  SEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT- 287
             E+ K Q   + ++  +L  +            ++  +  +G ++     S ANS+VA  
Sbjct: 1315 IEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQW 1374

Query: 288  ---IPTDTPLKEENEGFVKVTDAPNKSEISKHIEV---------QVAQETRNVSTGSAEN 335
                 TD   + E     K   A    E  +H+E          +  Q  +N       +
Sbjct: 1375 RTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLD 1434

Query: 336  EEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIG 395
             E+S          + + DK LS +K     T+  E +A  + + SL  EL         
Sbjct: 1435 VERSNAACAALDKKQRNFDKVLSEWKQKYEETQA-ELEASQKESRSLSTELF-------- 1485

Query: 396  DVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 455
                         +V+N+  E+   LET    N      I+ + E   E      ELE +
Sbjct: 1486 -------------KVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKI 1532

Query: 456  KQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMER 515
            K          +++E+E  + +A  E+A    + ++   +         + E+ R + E+
Sbjct: 1533 K----------KQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEK 1582

Query: 516  ----NQYKERLMELQEAVRWTEMIRASRENPAMQEKKR 549
                +Q K     + E ++ T        N A++ KK+
Sbjct: 1583 DEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKK 1620



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 99/480 (20%), Positives = 188/480 (39%), Gaps = 103/480 (21%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKF 103
            EE  K+L   +    E++++V A+    +   + L+++ E L+   ER  A     ++K 
Sbjct: 1390 EEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQ 1449

Query: 104  IEFE---DSQEQEKKDLQTRVESLESQTRQLE---LKAKNY----ADQISRLEEREAELK 153
              F+      +Q+ ++ Q  +E+ + ++R L     K KN      DQ+  L      L+
Sbjct: 1450 RNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQ 1509

Query: 154  KEYNALHQRHTE---MIHNY---MEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
            +E + L ++  E    IH      + +E+ K    +  ++ E++      K   I L   
Sbjct: 1510 QEISDLTEQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQL--- 1566

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDV 267
                                        EL+Q +S    K++         E+++E+  +
Sbjct: 1567 ----------------------------ELNQVKSEVDRKIA---------EKDEEIDQL 1589

Query: 268  SQGGSKAT-TPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS-KHIEVQVAQET 325
             +  ++   T  ST ++++ +      +K++ EG +      N+ EI   H     A+  
Sbjct: 1590 KRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDL------NEMEIQLNHANRLAAESL 1643

Query: 326  RNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA--FDRNTESLF 383
            RN              Q I++ T +L +D  L G +        +E +A       E L+
Sbjct: 1644 RNYRN----------TQGILKET-QLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELW 1692

Query: 384  EELSSAG-SGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELT 442
              L     S  I +     +LL     V+ L  +NT L+ TK  L   +ND+        
Sbjct: 1693 ATLEQTERSRKIAE----QELLDASERVQLLHTQNTSLINTKKKL---ENDV-------- 1737

Query: 443  CEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKR 502
                 LQ E+E V Q       ++R  EE+ +KA  +A    ++ K + D+     + K+
Sbjct: 1738 ---SQLQSEVEEVIQ-------ESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1787



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 100/461 (21%), Positives = 182/461 (39%), Gaps = 81/461 (17%)

Query: 69   QEHQVELELLRDDNEQL------ITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVE 122
            +E   +LE LR +N+ L      +T+   E   + H  EK    +   EQEK ++Q  +E
Sbjct: 1492 EESLDQLETLRRENKNLQQEISDLTEQIAEGGKQIHELEKI---KKQVEQEKCEIQAALE 1548

Query: 123  SLESQTRQLE---LKAKNYADQI-SRLEEREAELKKEYNALHQRHTEMIHNYMEHLE--- 175
              E+     E   L+ +   +Q+ S ++ + AE  +E + L + HT ++      L+   
Sbjct: 1549 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEI 1608

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKG--GETP------ 227
            R++   L    ++E   +     E  I L      A + L      +G   ET       
Sbjct: 1609 RSRNDALRVKKKMEGDLN-----EMEIQLNHANRLAAESLRNYRNTQGILKETQLHLDDA 1663

Query: 228  --GSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQ----GGSKATTPASTA 281
              G E  K ++L+      +L  +   E    +EQ +    +++      S+      T 
Sbjct: 1664 LRGQEDLK-EQLAIVERRANLLQAEIEELWATLEQTERSRKIAEQELLDASERVQLLHTQ 1722

Query: 282  NSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEV 341
            N+ +     +T  K EN+           S++   +E +V QE+RN     AE + K  +
Sbjct: 1723 NTSLI----NTKKKLEND----------VSQLQSEVE-EVIQESRN-----AEEKAKKAI 1762

Query: 342  QAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS-GLIGDVDEG 400
                    EL  ++D S +            K  ++  + L   L  A    L G   + 
Sbjct: 1763 TDAAMMAEELKKEQDTSAHLERM-------KKNLEQTVKDLQHRLDEAEQLALKGGKKQI 1815

Query: 401  ADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEK--------------D 446
              L    RE+E  + EN Q    +    + K++   +V ELT +               D
Sbjct: 1816 QKLEARVRELEGEV-ENEQKRNAEAVKGLRKHE--RRVKELTYQTEEDRKNVLRLQDLVD 1872

Query: 447  VLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKA 487
             LQ ++++ K+   + EE++     + RK + E E+A ++A
Sbjct: 1873 KLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERA 1913


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 139/683 (20%), Positives = 274/683 (40%), Gaps = 108/683 (15%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            +  E E + G  +E   K      + + +++ S+ +Q Q+ Q   ELL+++  Q +    
Sbjct: 1285 LQNEVESVTGMLNEAEGK-----AIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVST 1336

Query: 91   REKALRKHAEEKFIEFEDSQEQE---KKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
            + + L    EE+    +D  ++E   K++L+  + +L  Q    + K +++A  +  LEE
Sbjct: 1337 KLRQL----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
             +   +KE   L Q++ E    Y + LE+TK       D L     ++ +          
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQRQ---------- 1441

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDV 267
                    L  + +K       +Q KF +L     + S K ++  +  +A  +E E   +
Sbjct: 1442 --------LVSNLEK-------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486

Query: 268  SQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 327
            S   ++A   A  A  ++    T+  LK E E  V   D   K+ + +  + + A ET+ 
Sbjct: 1487 SL--ARALEEALEAKEELER--TNKMLKAEMEDLVSSKDDVGKN-VHELEKSKRALETQM 1541

Query: 328  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 387
                +   E + E+QA  ++  +L ++ ++   KG            F+R+ ++  E+  
Sbjct: 1542 EEMKTQLEELEDELQATEDA--KLRLEVNMQALKGQ-----------FERDLQARDEQNE 1588

Query: 388  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDV 447
                 L   + E         E+E+   +       K  L     DL  + D        
Sbjct: 1589 EKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLELQAD------SA 1636

Query: 448  LQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD-------------DSD 494
            ++G  EA+KQ + KL+ + ++ + EL  ARA  ++    AK+++               D
Sbjct: 1637 IKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695

Query: 495  IPTAQR--------KRFTRVEMARVLMERN--QYKERLMELQEAVRWTEMIRASRENPAM 544
            +  A+R        K     E+A  L  RN  Q ++R +E + A    E+        AM
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755

Query: 545  QEKKRSSIWQF--FSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGD 602
             ++ R +  Q    S   ++  +T +K E        +    +    K+  S L ++ G 
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNE--------SARQQLERQNKELRSKLHEMEGA 1807

Query: 603  KSKAFDFLSEETEASLASRREQKREQYRQVKA---HVQKEDGRVQAFGWSLPQKYKQVTN 659
                F       EA +A   EQ  ++ R+ +A    ++++D +++     +  + K    
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867

Query: 660  GQGENKMKNLPVPVYLRPLDEKD 682
             + + +  N  V    R L+E +
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAE 1890



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 152/817 (18%), Positives = 321/817 (39%), Gaps = 137/817 (16%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R D+E+         ++EL   +  + E+LDS  A       Q ++   ELE 
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--------ESQTR 129
            L+ + E  +     ++ LR   E++    + + ++E +  + +V+ +        E  T 
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 130  QLEL--KAKNYADQISR-LEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            QLE   +AK   D+  + LE+  A+L  E   L Q   E+ H   +   + +  Q   SD
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 187  ------QLESTAHSRIRKERPISLGIFPLPAGDGL-LTPDAQKGGETPGSEQWKFQELSQ 239
                  +L    H +++ E     G+     G  + L  D           Q   QE ++
Sbjct: 1271 GERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329

Query: 240  PRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE 299
             + + S K+    E + +++  D+L +  +         ST N  ++        K++ +
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQ--DQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQ 1381

Query: 300  GFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD---- 352
             F    +A    K    K IE    Q     +      + K+ +Q  ++    +LD    
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441

Query: 353  ----MDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEGADLLG- 405
                ++K    +       K I +K  D     E+   E  +    L   ++E  +    
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 406  -------MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 458
                   +  E+E+L+     + +  + L   K  L  +++E+  + + L+ EL+A + A
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 459  KLKL----------------------EEKNRELEEELRKARAEAEDARQK------AKDD 490
            KL+L                      EEK R+L+ +L +   E ED R++      AK  
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621

Query: 491  DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRS 550
             + D+   + +  + ++     ++  Q ++   ++++  R  E  RASR+          
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIK--QLRKLQAQMKDFQRELEDARASRD---------- 1669

Query: 551  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 610
                    +F+++    KK +   +L+ +        +  +R+   + L  ++      L
Sbjct: 1670 -------EIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLEKEE------L 1713

Query: 611  SEETEASLASRREQKREQYR------QVKAHVQKEDGRVQAFG---WSLPQKYKQVTN-- 659
            +EE  +SL+ R   + E+ R      Q++  +++E G ++A         Q+ +Q++N  
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 660  -GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAG 718
              +     KN      L     K+   KL    G      K++   ++         +  
Sbjct: 1774 ATERSTAQKNESARQQLE-RQNKELRSKLHEMEG----AVKSKFKSTIAALEAKIAQLEE 1828

Query: 719  LDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 755
               + ++++ A+  SL + D++LKE   +++++ +++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 143/685 (20%), Positives = 269/685 (39%), Gaps = 122/685 (17%)

Query: 117  LQTRVESLESQTRQLE-LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            L T+V+ L   TRQ E ++AK   D++ + +ER+ + + E   L Q+H+++        +
Sbjct: 837  LFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEE-----K 889

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                 QL    +L + A     +E  + L        + L   +A+   E    +Q    
Sbjct: 890  NLLQEQLQAETELYAEA-----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ---- 940

Query: 236  ELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLK 295
                      L+       Q+ ++ E++L +      K      TA + +         K
Sbjct: 941  ----------LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI---------K 981

Query: 296  EENEGFVKVTDAPNK-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD 354
            +  +  + + D  NK S+  K +E +++  T N+    AE EEK++    +++  E  M 
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNL----AEEEEKAKNLTKLKNKHE-SMI 1036

Query: 355  KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG-ADLLGMGREVENL 413
             +L            +  K  +++ + L E+L     G   D  E  ADL     E++  
Sbjct: 1037 SELE-----------VRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 414  ILENTQLLETKNALN----IVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 469
            + +  + L+   A        KN+ + K+ EL      LQ +L++ + A+ K E++ R+L
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 470  EEELRKARAEAEDA--------RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKER 521
             EEL   + E ED           +AK + +  +        TR   A+V   R ++ + 
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 522  LMELQEAVRWTEMIRASRE-NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNA 580
            + EL E +   +  +A+ + N    EK+ + +      L  +      K           
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---------- 1254

Query: 581  PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED 640
                     KK  + + +L   +SK  D   E   A L  +  + + +   V   + + +
Sbjct: 1255 ---------KKLEAQVQEL---QSKCSD--GERARAELNDKVHKLQNEVESVTGMLNEAE 1300

Query: 641  GRVQAFGWSLPQKYKQVTNGQ---GENKMKNLPVPVYLRPLDEKDTSM------------ 685
            G+       +     Q+ + Q    E   + L V   LR L+E+  S+            
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360

Query: 686  ---KLWCAVGVNLSGGKTR--DGGSVV-----GASVFYKDVAGLDTEGSKQRSASQSSLD 735
               +    + + LS  K +  D  S V     G   F K++  L T+  ++++A+   L+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL-TQQYEEKAAAYDKLE 1419

Query: 736  K----LDQELKEQQKELKNQEELSS 756
            K    L QEL +   +L NQ +L S
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVS 1444



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 144/758 (18%), Positives = 296/758 (39%), Gaps = 119/758 (15%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLIT-------QYEREKALRKHAEEKFIEFEDSQE 111
            + L     + Q+ + EL+ L   + QL         Q + E  L   AEE  +     ++
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918

Query: 112  QEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
            + ++   +++ R+E  E + +QL+ + K  A Q+  LEE   +L++E  A  +   E + 
Sbjct: 919  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE---QLEEEEAARQKLQLEKV- 974

Query: 169  NYMEHLERTKLHQLSGSDQLESTAHSRIRKERP-ISLGIFPLPAGDGLLTPDAQKGGETP 227
                     K+ +L     +    ++++ KER  +   I  L          A+   +  
Sbjct: 975  -----TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 228  GSEQWKFQEL-----SQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTAN 282
               +    EL      + +S   L+         A +  ++++D+    ++     +   
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 283  SDV--ATIPTDTPLKEENEGFVKVTDAPNKSEISKHI-EVQVAQETRNVSTGSAENEEK- 338
             ++  A    D  + ++N    K+       E+  HI ++Q   ++   +   AE +++ 
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKI------RELEGHISDLQEDLDSERAARNKAEKQKRD 1143

Query: 339  --SEVQAI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIG 395
               E++A+  E    LD        +        +  KA D  T S   ++         
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203

Query: 396  DVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 455
             V+E  + L   +  +  + +N Q LE +NA                     L GEL  +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENA--------------------DLAGELRVL 1243

Query: 456  KQAKLKLEEKNRELEEELR----------KARAEAEDARQKAKDDDDSDIPTAQRKRFTR 505
             QAK ++E K ++LE +++          +ARAE  D   K +++ +S            
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 506  VEMAR-VLMERNQYKERLMELQEAVRW-----TEMIRASRENPAMQE------KKRSSIW 553
            +++A+ V    +Q ++    LQE  R      T++ +   E  ++Q+      + + ++ 
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363

Query: 554  QFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR----SSTLSQLPGDKSKAFDF 609
            +  S L    S++ KK      L+  A T       KKR       L+Q   +K+ A+D 
Sbjct: 1364 RHISTLNIQLSDSKKK------LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417

Query: 610  LSEETEASLASRREQ---KREQYRQVKAHVQKED---GRVQAFGWSLPQKY-KQVTNGQG 662
            L E+T+  L    +      +  RQ+ ++++K+     ++ A   ++  KY  +    + 
Sbjct: 1418 L-EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 663  ENKMKNLPVPVYLRPLDEK-------DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKD 715
            E + K        R L+E        + + K+  A   +L   K   G +V         
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--------- 1527

Query: 716  VAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEE 753
                  E  K + A ++ ++++  +L+E + EL+  E+
Sbjct: 1528 -----HELEKSKRALETQMEEMKTQLEELEDELQATED 1560



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 138/706 (19%), Positives = 275/706 (38%), Gaps = 114/706 (16%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            ++LE+ +  +EE      +  E+V+  A     E E L+       + +   L+   + +
Sbjct: 953  LDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            L +  A+++E    L  L++ +E +I++ E      + + ++  + +   E +  D   +
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 121  VESLESQTRQLELK-AKNYADQISRLEEREAELKKEYNALHQ-RHTE------------- 165
            +  L++Q  +L+++ AK   +  + L   + E+ ++ NAL + R  E             
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130

Query: 166  -MIHNYMEHLERTKLHQLSG-----SDQLESTA-HSRIRKERPISLGIFPLPAGDGLLTP 218
                N  E  +R    +L        D L+STA    +R +R   + +      +   + 
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 219  DA------QKGGE-----TPGSEQWKFQELSQPRSHTSLKVSNSP--------------- 252
            +A      QK  +     T   EQ+K  + +  ++  +L+  N+                
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250

Query: 253  --EPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT-IPTDTPLKEENEG-FVKVT-DA 307
              + +K   Q  EL      G +A    +     +   + + T +  E EG  +K+  D 
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310

Query: 308  PNKSEISKHIEVQVAQETR---NVSTGSAE-NEEKSEVQAIIESTPELDMDKDLSGYKGS 363
             + S   +  +  + +ETR   NVST   +  EE++ +Q  ++   E++  ++L      
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE--EMEAKQNL------ 1362

Query: 364  STPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMG-----REVENLILENT 418
                        +R+  +L  +LS +   L  D     + L  G     +E+ENL  +  
Sbjct: 1363 ------------ERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 419  QLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA 478
            +     + L   KN L  ++D+L         +L+  +Q    LE+K R+ ++ L    A
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVV-------DLDNQRQLVSNLEKKQRKFDQLL----A 1458

Query: 479  EAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRAS 538
            E ++   K  D+ D     A+ K    + +AR L E  + KE      E  R  +M++A 
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAE 1512

Query: 539  RENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQ 598
             E+    +           +  S  +  T+  E    L+        T   K R     Q
Sbjct: 1513 MEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 599  LPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 644
                       L  + E  L +R EQ  E+ RQ++  + + +  ++
Sbjct: 1571 A----------LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 113/563 (20%), Positives = 219/563 (38%), Gaps = 117/563 (20%)

Query: 33   REFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYERE 92
            +E E L  +Y+E+          A  + L+    + Q+   +L +  D+  QL++  E++
Sbjct: 1399 KEIENLTQQYEEKA---------AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 93   K-------ALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE--LKAKNYADQIS 143
            +       A  K+   K+ +  D  E E ++ +T+  SL    R LE  L+AK   ++ +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKEELERTN 1506

Query: 144  RLEEREAE--------LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR 195
            ++ + E E        + K  + L ++    +   ME + +T+L +L   D+L++T  ++
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHEL-EKSKRALETQMEEM-KTQLEELE--DELQATEDAK 1562

Query: 196  IRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQ 255
            +R E         + A  G    D Q   E    ++ + Q                   +
Sbjct: 1563 LRLE-------VNMQALKGQFERDLQARDEQNEEKRRQLQ-------------------R 1596

Query: 256  KAVEQEDELSDVSQGGSKATTPASTANSDVATIP--TDTPLKEENEGFVKVTDAPNKSEI 313
            +  E E EL D  +  + A         D+  +    D+ +K   E   ++     + + 
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656

Query: 314  SKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENK 373
             +  E++ A+ +R+    +A+  EK   +A       + + +DL+  + +         K
Sbjct: 1657 FQR-ELEDARASRDEIFATAKENEK---KAKSLEADLMQLQEDLAAAERA--------RK 1704

Query: 374  AFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKND 433
              D   E L EEL+S+ SG     DE        R +E  I +  + LE +       +D
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEK-------RRLEARIAQLEEELEEEQGNMEAMSD 1757

Query: 434  LIAKV--------DELTCEKDVLQG--------------------ELEAVKQAKLK---- 461
             + K         +EL  E+   Q                     E+E   ++K K    
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817

Query: 462  -LEEKNRELEE----ELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERN 516
             LE K  +LEE    E R+ +A  +  +QK K   +  +     ++       +      
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 517  QYKERLMELQEAVRWTEMIRASR 539
            + K+   +L+EA   ++ I A+R
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANR 1900


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 139/683 (20%), Positives = 274/683 (40%), Gaps = 108/683 (15%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            +  E E + G  +E   K      + + +++ S+ +Q Q+ Q   ELL+++  Q +    
Sbjct: 1292 LQNEVESVTGMLNEAEGK-----AIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVST 1343

Query: 91   REKALRKHAEEKFIEFEDSQEQE---KKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
            + + L    EE+    +D  ++E   K++L+  + +L  Q    + K +++A  +  LEE
Sbjct: 1344 KLRQL----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
             +   +KE   L Q++ E    Y + LE+TK       D L     ++ +          
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQRQ---------- 1448

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDV 267
                    L  + +K       +Q KF +L     + S K ++  +  +A  +E E   +
Sbjct: 1449 --------LVSNLEK-------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493

Query: 268  SQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 327
            S   ++A   A  A  ++    T+  LK E E  V   D   K+ + +  + + A ET+ 
Sbjct: 1494 SL--ARALEEALEAKEELER--TNKMLKAEMEDLVSSKDDVGKN-VHELEKSKRALETQM 1548

Query: 328  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 387
                +   E + E+QA  ++  +L ++ ++   KG            F+R+ ++  E+  
Sbjct: 1549 EEMKTQLEELEDELQATEDA--KLRLEVNMQALKGQ-----------FERDLQARDEQNE 1595

Query: 388  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDV 447
                 L   + E         E+E+   +       K  L     DL  + D        
Sbjct: 1596 EKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLELQAD------SA 1643

Query: 448  LQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD-------------DSD 494
            ++G  EA+KQ + KL+ + ++ + EL  ARA  ++    AK+++               D
Sbjct: 1644 IKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702

Query: 495  IPTAQR--------KRFTRVEMARVLMERN--QYKERLMELQEAVRWTEMIRASRENPAM 544
            +  A+R        K     E+A  L  RN  Q ++R +E + A    E+        AM
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762

Query: 545  QEKKRSSIWQF--FSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGD 602
             ++ R +  Q    S   ++  +T +K E        +    +    K+  S L ++ G 
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNE--------SARQQLERQNKELRSKLHEMEGA 1814

Query: 603  KSKAFDFLSEETEASLASRREQKREQYRQVKA---HVQKEDGRVQAFGWSLPQKYKQVTN 659
                F       EA +A   EQ  ++ R+ +A    ++++D +++     +  + K    
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

Query: 660  GQGENKMKNLPVPVYLRPLDEKD 682
             + + +  N  V    R L+E +
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAE 1897



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 152/817 (18%), Positives = 321/817 (39%), Gaps = 137/817 (16%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R D+E+         ++EL   +  + E+LDS  A       Q ++   ELE 
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--------ESQTR 129
            L+ + E  +     ++ LR   E++    + + ++E +  + +V+ +        E  T 
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 130  QLEL--KAKNYADQISR-LEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            QLE   +AK   D+  + LE+  A+L  E   L Q   E+ H   +   + +  Q   SD
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 187  ------QLESTAHSRIRKERPISLGIFPLPAGDGL-LTPDAQKGGETPGSEQWKFQELSQ 239
                  +L    H +++ E     G+     G  + L  D           Q   QE ++
Sbjct: 1278 GERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336

Query: 240  PRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE 299
             + + S K+    E + +++  D+L +  +         ST N  ++        K++ +
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQ--DQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQ 1388

Query: 300  GFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD---- 352
             F    +A    K    K IE    Q     +      + K+ +Q  ++    +LD    
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448

Query: 353  ----MDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEGADLLG- 405
                ++K    +       K I +K  D     E+   E  +    L   ++E  +    
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508

Query: 406  -------MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 458
                   +  E+E+L+     + +  + L   K  L  +++E+  + + L+ EL+A + A
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 459  KLKL----------------------EEKNRELEEELRKARAEAEDARQK------AKDD 490
            KL+L                      EEK R+L+ +L +   E ED R++      AK  
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628

Query: 491  DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRS 550
             + D+   + +  + ++     ++  Q ++   ++++  R  E  RASR+          
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIK--QLRKLQAQMKDFQRELEDARASRD---------- 1676

Query: 551  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 610
                    +F+++    KK +   +L+ +        +  +R+   + L  ++      L
Sbjct: 1677 -------EIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLEKEE------L 1720

Query: 611  SEETEASLASRREQKREQYR------QVKAHVQKEDGRVQAFG---WSLPQKYKQVTN-- 659
            +EE  +SL+ R   + E+ R      Q++  +++E G ++A         Q+ +Q++N  
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 660  -GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAG 718
              +     KN      L     K+   KL    G      K++   ++         +  
Sbjct: 1781 ATERSTAQKNESARQQLE-RQNKELRSKLHEMEG----AVKSKFKSTIAALEAKIAQLEE 1835

Query: 719  LDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 755
               + ++++ A+  SL + D++LKE   +++++ +++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 143/685 (20%), Positives = 269/685 (39%), Gaps = 122/685 (17%)

Query: 117  LQTRVESLESQTRQLE-LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            L T+V+ L   TRQ E ++AK   D++ + +ER+ + + E   L Q+H+++        +
Sbjct: 844  LFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEE-----K 896

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                 QL    +L + A     +E  + L        + L   +A+   E    +Q    
Sbjct: 897  NLLQEQLQAETELYAEA-----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ---- 947

Query: 236  ELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLK 295
                      L+       Q+ ++ E++L +      K      TA + +         K
Sbjct: 948  ----------LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI---------K 988

Query: 296  EENEGFVKVTDAPNK-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD 354
            +  +  + + D  NK S+  K +E +++  T N+    AE EEK++    +++  E  M 
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNL----AEEEEKAKNLTKLKNKHE-SMI 1043

Query: 355  KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG-ADLLGMGREVENL 413
             +L            +  K  +++ + L E+L     G   D  E  ADL     E++  
Sbjct: 1044 SELE-----------VRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 414  ILENTQLLETKNALN----IVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 469
            + +  + L+   A        KN+ + K+ EL      LQ +L++ + A+ K E++ R+L
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 470  EEELRKARAEAEDA--------RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKER 521
             EEL   + E ED           +AK + +  +        TR   A+V   R ++ + 
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 522  LMELQEAVRWTEMIRASRE-NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNA 580
            + EL E +   +  +A+ + N    EK+ + +      L  +      K           
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---------- 1261

Query: 581  PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED 640
                     KK  + + +L   +SK  D   E   A L  +  + + +   V   + + +
Sbjct: 1262 ---------KKLEAQVQEL---QSKCSD--GERARAELNDKVHKLQNEVESVTGMLNEAE 1307

Query: 641  GRVQAFGWSLPQKYKQVTNGQ---GENKMKNLPVPVYLRPLDEKDTSM------------ 685
            G+       +     Q+ + Q    E   + L V   LR L+E+  S+            
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367

Query: 686  ---KLWCAVGVNLSGGKTR--DGGSVV-----GASVFYKDVAGLDTEGSKQRSASQSSLD 735
               +    + + LS  K +  D  S V     G   F K++  L T+  ++++A+   L+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL-TQQYEEKAAAYDKLE 1426

Query: 736  K----LDQELKEQQKELKNQEELSS 756
            K    L QEL +   +L NQ +L S
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVS 1451



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 144/758 (18%), Positives = 296/758 (39%), Gaps = 119/758 (15%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLIT-------QYEREKALRKHAEEKFIEFEDSQE 111
            + L     + Q+ + EL+ L   + QL         Q + E  L   AEE  +     ++
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925

Query: 112  QEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
            + ++   +++ R+E  E + +QL+ + K  A Q+  LEE   +L++E  A  +   E + 
Sbjct: 926  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE---QLEEEEAARQKLQLEKV- 981

Query: 169  NYMEHLERTKLHQLSGSDQLESTAHSRIRKERP-ISLGIFPLPAGDGLLTPDAQKGGETP 227
                     K+ +L     +    ++++ KER  +   I  L          A+   +  
Sbjct: 982  -----TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 228  GSEQWKFQEL-----SQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTAN 282
               +    EL      + +S   L+         A +  ++++D+    ++     +   
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 283  SDV--ATIPTDTPLKEENEGFVKVTDAPNKSEISKHI-EVQVAQETRNVSTGSAENEEK- 338
             ++  A    D  + ++N    K+       E+  HI ++Q   ++   +   AE +++ 
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKI------RELEGHISDLQEDLDSERAARNKAEKQKRD 1150

Query: 339  --SEVQAI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIG 395
               E++A+  E    LD        +        +  KA D  T S   ++         
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210

Query: 396  DVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 455
             V+E  + L   +  +  + +N Q LE +NA                     L GEL  +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENA--------------------DLAGELRVL 1250

Query: 456  KQAKLKLEEKNRELEEELR----------KARAEAEDARQKAKDDDDSDIPTAQRKRFTR 505
             QAK ++E K ++LE +++          +ARAE  D   K +++ +S            
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 506  VEMAR-VLMERNQYKERLMELQEAVRW-----TEMIRASRENPAMQE------KKRSSIW 553
            +++A+ V    +Q ++    LQE  R      T++ +   E  ++Q+      + + ++ 
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370

Query: 554  QFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR----SSTLSQLPGDKSKAFDF 609
            +  S L    S++ KK      L+  A T       KKR       L+Q   +K+ A+D 
Sbjct: 1371 RHISTLNIQLSDSKKK------LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424

Query: 610  LSEETEASLASRREQ---KREQYRQVKAHVQKED---GRVQAFGWSLPQKY-KQVTNGQG 662
            L E+T+  L    +      +  RQ+ ++++K+     ++ A   ++  KY  +    + 
Sbjct: 1425 L-EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 663  ENKMKNLPVPVYLRPLDEK-------DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKD 715
            E + K        R L+E        + + K+  A   +L   K   G +V         
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--------- 1534

Query: 716  VAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEE 753
                  E  K + A ++ ++++  +L+E + EL+  E+
Sbjct: 1535 -----HELEKSKRALETQMEEMKTQLEELEDELQATED 1567



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 138/706 (19%), Positives = 275/706 (38%), Gaps = 114/706 (16%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            ++LE+ +  +EE      +  E+V+  A     E E L+       + +   L+   + +
Sbjct: 960  LDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            L +  A+++E    L  L++ +E +I++ E      + + ++  + +   E +  D   +
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 121  VESLESQTRQLELK-AKNYADQISRLEEREAELKKEYNALHQ-RHTE------------- 165
            +  L++Q  +L+++ AK   +  + L   + E+ ++ NAL + R  E             
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137

Query: 166  -MIHNYMEHLERTKLHQLSG-----SDQLESTA-HSRIRKERPISLGIFPLPAGDGLLTP 218
                N  E  +R    +L        D L+STA    +R +R   + +      +   + 
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 219  DA------QKGGE-----TPGSEQWKFQELSQPRSHTSLKVSNSP--------------- 252
            +A      QK  +     T   EQ+K  + +  ++  +L+  N+                
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257

Query: 253  --EPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT-IPTDTPLKEENEG-FVKVT-DA 307
              + +K   Q  EL      G +A    +     +   + + T +  E EG  +K+  D 
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317

Query: 308  PNKSEISKHIEVQVAQETR---NVSTGSAE-NEEKSEVQAIIESTPELDMDKDLSGYKGS 363
             + S   +  +  + +ETR   NVST   +  EE++ +Q  ++   E++  ++L      
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE--EMEAKQNL------ 1369

Query: 364  STPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMG-----REVENLILENT 418
                        +R+  +L  +LS +   L  D     + L  G     +E+ENL  +  
Sbjct: 1370 ------------ERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 419  QLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA 478
            +     + L   KN L  ++D+L         +L+  +Q    LE+K R+ ++ L    A
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVV-------DLDNQRQLVSNLEKKQRKFDQLL----A 1465

Query: 479  EAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRAS 538
            E ++   K  D+ D     A+ K    + +AR L E  + KE      E  R  +M++A 
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAE 1519

Query: 539  RENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQ 598
             E+    +           +  S  +  T+  E    L+        T   K R     Q
Sbjct: 1520 MEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 599  LPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 644
                       L  + E  L +R EQ  E+ RQ++  + + +  ++
Sbjct: 1578 A----------LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 113/563 (20%), Positives = 219/563 (38%), Gaps = 117/563 (20%)

Query: 33   REFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYERE 92
            +E E L  +Y+E+          A  + L+    + Q+   +L +  D+  QL++  E++
Sbjct: 1406 KEIENLTQQYEEKA---------AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 93   K-------ALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE--LKAKNYADQIS 143
            +       A  K+   K+ +  D  E E ++ +T+  SL    R LE  L+AK   ++ +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKEELERTN 1513

Query: 144  RLEEREAE--------LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR 195
            ++ + E E        + K  + L ++    +   ME + +T+L +L   D+L++T  ++
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHEL-EKSKRALETQMEEM-KTQLEELE--DELQATEDAK 1569

Query: 196  IRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQ 255
            +R E         + A  G    D Q   E    ++ + Q                   +
Sbjct: 1570 LRLE-------VNMQALKGQFERDLQARDEQNEEKRRQLQ-------------------R 1603

Query: 256  KAVEQEDELSDVSQGGSKATTPASTANSDVATIP--TDTPLKEENEGFVKVTDAPNKSEI 313
            +  E E EL D  +  + A         D+  +    D+ +K   E   ++     + + 
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663

Query: 314  SKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENK 373
             +  E++ A+ +R+    +A+  EK   +A       + + +DL+  + +         K
Sbjct: 1664 FQR-ELEDARASRDEIFATAKENEK---KAKSLEADLMQLQEDLAAAERA--------RK 1711

Query: 374  AFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKND 433
              D   E L EEL+S+ SG     DE        R +E  I +  + LE +       +D
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEK-------RRLEARIAQLEEELEEEQGNMEAMSD 1764

Query: 434  LIAKV--------DELTCEKDVLQG--------------------ELEAVKQAKLK---- 461
             + K         +EL  E+   Q                     E+E   ++K K    
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824

Query: 462  -LEEKNRELEE----ELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERN 516
             LE K  +LEE    E R+ +A  +  +QK K   +  +     ++       +      
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 517  QYKERLMELQEAVRWTEMIRASR 539
            + K+   +L+EA   ++ I A+R
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANR 1907


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 139/683 (20%), Positives = 274/683 (40%), Gaps = 108/683 (15%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            +  E E + G  +E   K      + + +++ S+ +Q Q+ Q   ELL+++  Q +    
Sbjct: 1292 LQNEVESVTGMLNEAEGK-----AIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVST 1343

Query: 91   REKALRKHAEEKFIEFEDSQEQE---KKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
            + + L    EE+    +D  ++E   K++L+  + +L  Q    + K +++A  +  LEE
Sbjct: 1344 KLRQL----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1399

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
             +   +KE   L Q++ E    Y + LE+TK       D L     ++ +          
Sbjct: 1400 GKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQRQ---------- 1448

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDV 267
                    L  + +K       +Q KF +L     + S K ++  +  +A  +E E   +
Sbjct: 1449 --------LVSNLEK-------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1493

Query: 268  SQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 327
            S   ++A   A  A  ++    T+  LK E E  V   D   K+ + +  + + A ET+ 
Sbjct: 1494 SL--ARALEEALEAKEELER--TNKMLKAEMEDLVSSKDDVGKN-VHELEKSKRALETQM 1548

Query: 328  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 387
                +   E + E+QA  ++  +L ++ ++   KG            F+R+ ++  E+  
Sbjct: 1549 EEMKTQLEELEDELQATEDA--KLRLEVNMQALKGQ-----------FERDLQARDEQNE 1595

Query: 388  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDV 447
                 L   + E         E+E+   +       K  L     DL  + D        
Sbjct: 1596 EKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLELQAD------SA 1643

Query: 448  LQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD-------------DSD 494
            ++G  EA+KQ + KL+ + ++ + EL  ARA  ++    AK+++               D
Sbjct: 1644 IKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1702

Query: 495  IPTAQR--------KRFTRVEMARVLMERN--QYKERLMELQEAVRWTEMIRASRENPAM 544
            +  A+R        K     E+A  L  RN  Q ++R +E + A    E+        AM
Sbjct: 1703 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1762

Query: 545  QEKKRSSIWQF--FSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGD 602
             ++ R +  Q    S   ++  +T +K E        +    +    K+  S L ++ G 
Sbjct: 1763 SDRVRKATQQAEQLSNELATERSTAQKNE--------SARQQLERQNKELRSKLHEMEGA 1814

Query: 603  KSKAFDFLSEETEASLASRREQKREQYRQVKA---HVQKEDGRVQAFGWSLPQKYKQVTN 659
                F       EA +A   EQ  ++ R+ +A    ++++D +++     +  + K    
Sbjct: 1815 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1874

Query: 660  GQGENKMKNLPVPVYLRPLDEKD 682
             + + +  N  V    R L+E +
Sbjct: 1875 YKEQAEKGNARVKQLKRQLEEAE 1897



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 152/817 (18%), Positives = 321/817 (39%), Gaps = 137/817 (16%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R D+E+         ++EL   +  + E+LDS  A       Q ++   ELE 
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--------ESQTR 129
            L+ + E  +     ++ LR   E++    + + ++E +  + +V+ +        E  T 
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1217

Query: 130  QLEL--KAKNYADQISR-LEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            QLE   +AK   D+  + LE+  A+L  E   L Q   E+ H   +   + +  Q   SD
Sbjct: 1218 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1277

Query: 187  ------QLESTAHSRIRKERPISLGIFPLPAGDGL-LTPDAQKGGETPGSEQWKFQELSQ 239
                  +L    H +++ E     G+     G  + L  D           Q   QE ++
Sbjct: 1278 GERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1336

Query: 240  PRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE 299
             + + S K+    E + +++  D+L +  +         ST N  ++        K++ +
Sbjct: 1337 QKLNVSTKLRQLEEERNSLQ--DQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQ 1388

Query: 300  GFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD---- 352
             F    +A    K    K IE    Q     +      + K+ +Q  ++    +LD    
Sbjct: 1389 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1448

Query: 353  ----MDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEGADLLG- 405
                ++K    +       K I +K  D     E+   E  +    L   ++E  +    
Sbjct: 1449 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1508

Query: 406  -------MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 458
                   +  E+E+L+     + +  + L   K  L  +++E+  + + L+ EL+A + A
Sbjct: 1509 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1568

Query: 459  KLKL----------------------EEKNRELEEELRKARAEAEDARQK------AKDD 490
            KL+L                      EEK R+L+ +L +   E ED R++      AK  
Sbjct: 1569 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1628

Query: 491  DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRS 550
             + D+   + +  + ++     ++  Q ++   ++++  R  E  RASR+          
Sbjct: 1629 LEGDLKDLELQADSAIKGREEAIK--QLRKLQAQMKDFQRELEDARASRD---------- 1676

Query: 551  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 610
                    +F+++    KK +   +L+ +        +  +R+   + L  ++      L
Sbjct: 1677 -------EIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLEKEE------L 1720

Query: 611  SEETEASLASRREQKREQYR------QVKAHVQKEDGRVQAFG---WSLPQKYKQVTN-- 659
            +EE  +SL+ R   + E+ R      Q++  +++E G ++A         Q+ +Q++N  
Sbjct: 1721 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1780

Query: 660  -GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAG 718
              +     KN      L     K+   KL    G      K++   ++         +  
Sbjct: 1781 ATERSTAQKNESARQQLE-RQNKELRSKLHEMEG----AVKSKFKSTIAALEAKIAQLEE 1835

Query: 719  LDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 755
               + ++++ A+  SL + D++LKE   +++++ +++
Sbjct: 1836 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1872



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 143/685 (20%), Positives = 269/685 (39%), Gaps = 122/685 (17%)

Query: 117  LQTRVESLESQTRQLE-LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            L T+V+ L   TRQ E ++AK   D++ + +ER+ + + E   L Q+H+++        +
Sbjct: 844  LFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEE-----K 896

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                 QL    +L + A     +E  + L        + L   +A+   E    +Q    
Sbjct: 897  NLLQEQLQAETELYAEA-----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ---- 947

Query: 236  ELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLK 295
                      L+       Q+ ++ E++L +      K      TA + +         K
Sbjct: 948  ----------LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI---------K 988

Query: 296  EENEGFVKVTDAPNK-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD 354
            +  +  + + D  NK S+  K +E +++  T N+    AE EEK++    +++  E  M 
Sbjct: 989  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNL----AEEEEKAKNLTKLKNKHE-SMI 1043

Query: 355  KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG-ADLLGMGREVENL 413
             +L            +  K  +++ + L E+L     G   D  E  ADL     E++  
Sbjct: 1044 SELE-----------VRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1091

Query: 414  ILENTQLLETKNALN----IVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 469
            + +  + L+   A        KN+ + K+ EL      LQ +L++ + A+ K E++ R+L
Sbjct: 1092 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 470  EEELRKARAEAEDA--------RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKER 521
             EEL   + E ED           +AK + +  +        TR   A+V   R ++ + 
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1211

Query: 522  LMELQEAVRWTEMIRASRE-NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNA 580
            + EL E +   +  +A+ + N    EK+ + +      L  +      K           
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---------- 1261

Query: 581  PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED 640
                     KK  + + +L   +SK  D   E   A L  +  + + +   V   + + +
Sbjct: 1262 ---------KKLEAQVQEL---QSKCSD--GERARAELNDKVHKLQNEVESVTGMLNEAE 1307

Query: 641  GRVQAFGWSLPQKYKQVTNGQ---GENKMKNLPVPVYLRPLDEKDTSM------------ 685
            G+       +     Q+ + Q    E   + L V   LR L+E+  S+            
Sbjct: 1308 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1367

Query: 686  ---KLWCAVGVNLSGGKTR--DGGSVV-----GASVFYKDVAGLDTEGSKQRSASQSSLD 735
               +    + + LS  K +  D  S V     G   F K++  L T+  ++++A+   L+
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL-TQQYEEKAAAYDKLE 1426

Query: 736  K----LDQELKEQQKELKNQEELSS 756
            K    L QEL +   +L NQ +L S
Sbjct: 1427 KTKNRLQQELDDLVVDLDNQRQLVS 1451



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 144/758 (18%), Positives = 296/758 (39%), Gaps = 119/758 (15%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLIT-------QYEREKALRKHAEEKFIEFEDSQE 111
            + L     + Q+ + EL+ L   + QL         Q + E  L   AEE  +     ++
Sbjct: 866  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 925

Query: 112  QEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
            + ++   +++ R+E  E + +QL+ + K  A Q+  LEE   +L++E  A  +   E + 
Sbjct: 926  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE---QLEEEEAARQKLQLEKV- 981

Query: 169  NYMEHLERTKLHQLSGSDQLESTAHSRIRKERP-ISLGIFPLPAGDGLLTPDAQKGGETP 227
                     K+ +L     +    ++++ KER  +   I  L          A+   +  
Sbjct: 982  -----TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1036

Query: 228  GSEQWKFQEL-----SQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTAN 282
               +    EL      + +S   L+         A +  ++++D+    ++     +   
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096

Query: 283  SDV--ATIPTDTPLKEENEGFVKVTDAPNKSEISKHI-EVQVAQETRNVSTGSAENEEK- 338
             ++  A    D  + ++N    K+       E+  HI ++Q   ++   +   AE +++ 
Sbjct: 1097 EELQAALARLDDEIAQKNNALKKI------RELEGHISDLQEDLDSERAARNKAEKQKRD 1150

Query: 339  --SEVQAI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIG 395
               E++A+  E    LD        +        +  KA D  T S   ++         
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1210

Query: 396  DVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 455
             V+E  + L   +  +  + +N Q LE +NA                     L GEL  +
Sbjct: 1211 AVEELTEQLEQFKRAKANLDKNKQTLEKENA--------------------DLAGELRVL 1250

Query: 456  KQAKLKLEEKNRELEEELR----------KARAEAEDARQKAKDDDDSDIPTAQRKRFTR 505
             QAK ++E K ++LE +++          +ARAE  D   K +++ +S            
Sbjct: 1251 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1310

Query: 506  VEMAR-VLMERNQYKERLMELQEAVRW-----TEMIRASRENPAMQE------KKRSSIW 553
            +++A+ V    +Q ++    LQE  R      T++ +   E  ++Q+      + + ++ 
Sbjct: 1311 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1370

Query: 554  QFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR----SSTLSQLPGDKSKAFDF 609
            +  S L    S++ KK      L+  A T       KKR       L+Q   +K+ A+D 
Sbjct: 1371 RHISTLNIQLSDSKKK------LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424

Query: 610  LSEETEASLASRREQ---KREQYRQVKAHVQKED---GRVQAFGWSLPQKY-KQVTNGQG 662
            L E+T+  L    +      +  RQ+ ++++K+     ++ A   ++  KY  +    + 
Sbjct: 1425 L-EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1483

Query: 663  ENKMKNLPVPVYLRPLDEK-------DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKD 715
            E + K        R L+E        + + K+  A   +L   K   G +V         
Sbjct: 1484 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--------- 1534

Query: 716  VAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEE 753
                  E  K + A ++ ++++  +L+E + EL+  E+
Sbjct: 1535 -----HELEKSKRALETQMEEMKTQLEELEDELQATED 1567



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 138/706 (19%), Positives = 275/706 (38%), Gaps = 114/706 (16%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            ++LE+ +  +EE      +  E+V+  A     E E L+       + +   L+   + +
Sbjct: 960  LDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1017

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            L +  A+++E    L  L++ +E +I++ E      + + ++  + +   E +  D   +
Sbjct: 1018 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 121  VESLESQTRQLELK-AKNYADQISRLEEREAELKKEYNALHQ-RHTE------------- 165
            +  L++Q  +L+++ AK   +  + L   + E+ ++ NAL + R  E             
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137

Query: 166  -MIHNYMEHLERTKLHQLSG-----SDQLESTA-HSRIRKERPISLGIFPLPAGDGLLTP 218
                N  E  +R    +L        D L+STA    +R +R   + +      +   + 
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 219  DA------QKGGE-----TPGSEQWKFQELSQPRSHTSLKVSNSP--------------- 252
            +A      QK  +     T   EQ+K  + +  ++  +L+  N+                
Sbjct: 1198 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1257

Query: 253  --EPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT-IPTDTPLKEENEG-FVKVT-DA 307
              + +K   Q  EL      G +A    +     +   + + T +  E EG  +K+  D 
Sbjct: 1258 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317

Query: 308  PNKSEISKHIEVQVAQETR---NVSTGSAE-NEEKSEVQAIIESTPELDMDKDLSGYKGS 363
             + S   +  +  + +ETR   NVST   +  EE++ +Q  ++   E++  ++L      
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE--EMEAKQNL------ 1369

Query: 364  STPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMG-----REVENLILENT 418
                        +R+  +L  +LS +   L  D     + L  G     +E+ENL  +  
Sbjct: 1370 ------------ERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYE 1416

Query: 419  QLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA 478
            +     + L   KN L  ++D+L         +L+  +Q    LE+K R+ ++ L    A
Sbjct: 1417 EKAAAYDKLEKTKNRLQQELDDLVV-------DLDNQRQLVSNLEKKQRKFDQLL----A 1465

Query: 479  EAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRAS 538
            E ++   K  D+ D     A+ K    + +AR L E  + KE      E  R  +M++A 
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAE 1519

Query: 539  RENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQ 598
             E+    +           +  S  +  T+  E    L+        T   K R     Q
Sbjct: 1520 MEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1577

Query: 599  LPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 644
                       L  + E  L +R EQ  E+ RQ++  + + +  ++
Sbjct: 1578 A----------LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 116/596 (19%), Positives = 230/596 (38%), Gaps = 117/596 (19%)

Query: 33   REFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYERE 92
            +E E L  +Y+E+          A  + L+    + Q+   +L +  D+  QL++  E++
Sbjct: 1406 KEIENLTQQYEEKA---------AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1456

Query: 93   K-------ALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE--LKAKNYADQIS 143
            +       A  K+   K+ +  D  E E ++ +T+  SL    R LE  L+AK   ++ +
Sbjct: 1457 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKEELERTN 1513

Query: 144  RLEEREAE--------LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR 195
            ++ + E E        + K  + L ++    +   ME + +T+L +L   D+L++T  ++
Sbjct: 1514 KMLKAEMEDLVSSKDDVGKNVHEL-EKSKRALETQMEEM-KTQLEELE--DELQATEDAK 1569

Query: 196  IRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQ 255
            +R E         + A  G    D Q   E    ++ + Q                   +
Sbjct: 1570 LRLE-------VNMQALKGQFERDLQARDEQNEEKRRQLQ-------------------R 1603

Query: 256  KAVEQEDELSDVSQGGSKATTPASTANSDVATIP--TDTPLKEENEGFVKVTDAPNKSEI 313
            +  E E EL D  +  + A         D+  +    D+ +K   E   ++     + + 
Sbjct: 1604 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1663

Query: 314  SKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENK 373
             +  E++ A+ +R+    +A+  EK   +A       + + +DL+  + +         K
Sbjct: 1664 FQR-ELEDARASRDEIFATAKENEK---KAKSLEADLMQLQEDLAAAERA--------RK 1711

Query: 374  AFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKND 433
              D   E L EEL+S+ SG     DE        R +E  I +  + LE +       +D
Sbjct: 1712 QADLEKEELAEELASSLSGRNALQDEK-------RRLEARIAQLEEELEEEQGNMEAMSD 1764

Query: 434  LIAKV--------DELTCEKDVLQG--------------------ELEAVKQAKLK---- 461
             + K         +EL  E+   Q                     E+E   ++K K    
Sbjct: 1765 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1824

Query: 462  -LEEKNRELEE----ELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERN 516
             LE K  +LEE    E R+ +A  +  +QK K   +  +     ++       +      
Sbjct: 1825 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1884

Query: 517  QYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEP 572
            + K+   +L+EA   ++ I A+R     +  + +   +   R  ++  +  + P P
Sbjct: 1885 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1940


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 139/683 (20%), Positives = 274/683 (40%), Gaps = 108/683 (15%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            +  E E + G  +E   K      + + +++ S+ +Q Q+ Q   ELL+++  Q +    
Sbjct: 1285 LQNEVESVTGMLNEAEGK-----AIKLAKDVASLSSQLQDTQ---ELLQEETRQKLNVST 1336

Query: 91   REKALRKHAEEKFIEFEDSQEQE---KKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
            + + L    EE+    +D  ++E   K++L+  + +L  Q    + K +++A  +  LEE
Sbjct: 1337 KLRQL----EEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEE 1392

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
             +   +KE   L Q++ E    Y + LE+TK       D L     ++ +          
Sbjct: 1393 GKKRFQKEIENLTQQYEEKAAAY-DKLEKTKNRLQQELDDLVVDLDNQRQ---------- 1441

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDV 267
                    L  + +K       +Q KF +L     + S K ++  +  +A  +E E   +
Sbjct: 1442 --------LVSNLEK-------KQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKAL 1486

Query: 268  SQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 327
            S   ++A   A  A  ++    T+  LK E E  V   D   K+ + +  + + A ET+ 
Sbjct: 1487 SL--ARALEEALEAKEELER--TNKMLKAEMEDLVSSKDDVGKN-VHELEKSKRALETQM 1541

Query: 328  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 387
                +   E + E+QA  ++  +L ++ ++   KG            F+R+ ++  E+  
Sbjct: 1542 EEMKTQLEELEDELQATEDA--KLRLEVNMQALKGQ-----------FERDLQARDEQNE 1588

Query: 388  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDV 447
                 L   + E         E+E+   +       K  L     DL  + D        
Sbjct: 1589 EKRRQLQRQLHE------YETELEDERKQRALAAAAKKKLEGDLKDLELQAD------SA 1636

Query: 448  LQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDD-------------DSD 494
            ++G  EA+KQ + KL+ + ++ + EL  ARA  ++    AK+++               D
Sbjct: 1637 IKGREEAIKQLR-KLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQED 1695

Query: 495  IPTAQR--------KRFTRVEMARVLMERN--QYKERLMELQEAVRWTEMIRASRENPAM 544
            +  A+R        K     E+A  L  RN  Q ++R +E + A    E+        AM
Sbjct: 1696 LAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM 1755

Query: 545  QEKKRSSIWQF--FSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGD 602
             ++ R +  Q    S   ++  +T +K E        +    +    K+  S L ++ G 
Sbjct: 1756 SDRVRKATQQAEQLSNELATERSTAQKNE--------SARQQLERQNKELRSKLHEMEGA 1807

Query: 603  KSKAFDFLSEETEASLASRREQKREQYRQVKA---HVQKEDGRVQAFGWSLPQKYKQVTN 659
                F       EA +A   EQ  ++ R+ +A    ++++D +++     +  + K    
Sbjct: 1808 VKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQ 1867

Query: 660  GQGENKMKNLPVPVYLRPLDEKD 682
             + + +  N  V    R L+E +
Sbjct: 1868 YKEQAEKGNARVKQLKRQLEEAE 1890



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 152/817 (18%), Positives = 321/817 (39%), Gaps = 137/817 (16%)

Query: 34   EFERLIGRYDEEV---------VKELMPLVVAVLENLDSVFA-------QDQEHQVELEL 77
            E +  + R D+E+         ++EL   +  + E+LDS  A       Q ++   ELE 
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 78   LRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--------ESQTR 129
            L+ + E  +     ++ LR   E++    + + ++E +  + +V+ +        E  T 
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTE 1210

Query: 130  QLEL--KAKNYADQISR-LEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            QLE   +AK   D+  + LE+  A+L  E   L Q   E+ H   +   + +  Q   SD
Sbjct: 1211 QLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSD 1270

Query: 187  ------QLESTAHSRIRKERPISLGIFPLPAGDGL-LTPDAQKGGETPGSEQWKFQELSQ 239
                  +L    H +++ E     G+     G  + L  D           Q   QE ++
Sbjct: 1271 GERARAELNDKVH-KLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETR 1329

Query: 240  PRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENE 299
             + + S K+    E + +++  D+L +  +         ST N  ++        K++ +
Sbjct: 1330 QKLNVSTKLRQLEEERNSLQ--DQLDEEMEAKQNLERHISTLNIQLSDS------KKKLQ 1381

Query: 300  GFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES-TPELD---- 352
             F    +A    K    K IE    Q     +      + K+ +Q  ++    +LD    
Sbjct: 1382 DFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQ 1441

Query: 353  ----MDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEELSSAGSGLIGDVDEGADLLG- 405
                ++K    +       K I +K  D     E+   E  +    L   ++E  +    
Sbjct: 1442 LVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEE 1501

Query: 406  -------MGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA 458
                   +  E+E+L+     + +  + L   K  L  +++E+  + + L+ EL+A + A
Sbjct: 1502 LERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDA 1561

Query: 459  KLKL----------------------EEKNRELEEELRKARAEAEDARQK------AKDD 490
            KL+L                      EEK R+L+ +L +   E ED R++      AK  
Sbjct: 1562 KLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKK 1621

Query: 491  DDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRS 550
             + D+   + +  + ++     ++  Q ++   ++++  R  E  RASR+          
Sbjct: 1622 LEGDLKDLELQADSAIKGREEAIK--QLRKLQAQMKDFQRELEDARASRD---------- 1669

Query: 551  SIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFL 610
                    +F+++    KK +   +L+ +        +  +R+   + L  ++      L
Sbjct: 1670 -------EIFATAKENEKKAK---SLEADLMQLQEDLAAAERARKQADLEKEE------L 1713

Query: 611  SEETEASLASRREQKREQYR------QVKAHVQKEDGRVQAFG---WSLPQKYKQVTN-- 659
            +EE  +SL+ R   + E+ R      Q++  +++E G ++A         Q+ +Q++N  
Sbjct: 1714 AEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNEL 1773

Query: 660  -GQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAG 718
              +     KN      L     K+   KL    G      K++   ++         +  
Sbjct: 1774 ATERSTAQKNESARQQLE-RQNKELRSKLHEMEG----AVKSKFKSTIAALEAKIAQLEE 1828

Query: 719  LDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELS 755
               + ++++ A+  SL + D++LKE   +++++ +++
Sbjct: 1829 QVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMA 1865



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 143/685 (20%), Positives = 269/685 (39%), Gaps = 122/685 (17%)

Query: 117  LQTRVESLESQTRQLE-LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            L T+V+ L   TRQ E ++AK   D++ + +ER+ + + E   L Q+H+++        +
Sbjct: 837  LFTKVKPLLQVTRQEEEMQAKE--DELQKTKERQQKAENELKELEQKHSQLTEE-----K 889

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
                 QL    +L + A     +E  + L        + L   +A+   E    +Q    
Sbjct: 890  NLLQEQLQAETELYAEA-----EEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQ---- 940

Query: 236  ELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLK 295
                      L+       Q+ ++ E++L +      K      TA + +         K
Sbjct: 941  ----------LQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKI---------K 981

Query: 296  EENEGFVKVTDAPNK-SEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD 354
            +  +  + + D  NK S+  K +E +++  T N+    AE EEK++    +++  E  M 
Sbjct: 982  KLEDEILVMDDQNNKLSKERKLLEERISDLTTNL----AEEEEKAKNLTKLKNKHE-SMI 1036

Query: 355  KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG-ADLLGMGREVENL 413
             +L            +  K  +++ + L E+L     G   D  E  ADL     E++  
Sbjct: 1037 SELE-----------VRLKKEEKSRQEL-EKLKRKLEGDASDFHEQIADLQAQIAELKMQ 1084

Query: 414  ILENTQLLETKNALN----IVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 469
            + +  + L+   A        KN+ + K+ EL      LQ +L++ + A+ K E++ R+L
Sbjct: 1085 LAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 470  EEELRKARAEAEDA--------RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKER 521
             EEL   + E ED           +AK + +  +        TR   A+V   R ++ + 
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQA 1204

Query: 522  LMELQEAVRWTEMIRASRE-NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNA 580
            + EL E +   +  +A+ + N    EK+ + +      L  +      K           
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK---------- 1254

Query: 581  PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED 640
                     KK  + + +L   +SK  D   E   A L  +  + + +   V   + + +
Sbjct: 1255 ---------KKLEAQVQEL---QSKCSD--GERARAELNDKVHKLQNEVESVTGMLNEAE 1300

Query: 641  GRVQAFGWSLPQKYKQVTNGQ---GENKMKNLPVPVYLRPLDEKDTSM------------ 685
            G+       +     Q+ + Q    E   + L V   LR L+E+  S+            
Sbjct: 1301 GKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQ 1360

Query: 686  ---KLWCAVGVNLSGGKTR--DGGSVV-----GASVFYKDVAGLDTEGSKQRSASQSSLD 735
               +    + + LS  K +  D  S V     G   F K++  L T+  ++++A+   L+
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL-TQQYEEKAAAYDKLE 1419

Query: 736  K----LDQELKEQQKELKNQEELSS 756
            K    L QEL +   +L NQ +L S
Sbjct: 1420 KTKNRLQQELDDLVVDLDNQRQLVS 1444



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 144/758 (18%), Positives = 296/758 (39%), Gaps = 119/758 (15%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLIT-------QYEREKALRKHAEEKFIEFEDSQE 111
            + L     + Q+ + EL+ L   + QL         Q + E  L   AEE  +     ++
Sbjct: 859  DELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQ 918

Query: 112  QEKK---DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH 168
            + ++   +++ R+E  E + +QL+ + K  A Q+  LEE   +L++E  A  +   E + 
Sbjct: 919  ELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE---QLEEEEAARQKLQLEKV- 974

Query: 169  NYMEHLERTKLHQLSGSDQLESTAHSRIRKERP-ISLGIFPLPAGDGLLTPDAQKGGETP 227
                     K+ +L     +    ++++ KER  +   I  L          A+   +  
Sbjct: 975  -----TAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLK 1029

Query: 228  GSEQWKFQEL-----SQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTAN 282
               +    EL      + +S   L+         A +  ++++D+    ++     +   
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089

Query: 283  SDV--ATIPTDTPLKEENEGFVKVTDAPNKSEISKHI-EVQVAQETRNVSTGSAENEEK- 338
             ++  A    D  + ++N    K+       E+  HI ++Q   ++   +   AE +++ 
Sbjct: 1090 EELQAALARLDDEIAQKNNALKKI------RELEGHISDLQEDLDSERAARNKAEKQKRD 1143

Query: 339  --SEVQAI-IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIG 395
               E++A+  E    LD        +        +  KA D  T S   ++         
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHAQ 1203

Query: 396  DVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 455
             V+E  + L   +  +  + +N Q LE +NA                     L GEL  +
Sbjct: 1204 AVEELTEQLEQFKRAKANLDKNKQTLEKENA--------------------DLAGELRVL 1243

Query: 456  KQAKLKLEEKNRELEEELR----------KARAEAEDARQKAKDDDDSDIPTAQRKRFTR 505
             QAK ++E K ++LE +++          +ARAE  D   K +++ +S            
Sbjct: 1244 GQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKA 1303

Query: 506  VEMAR-VLMERNQYKERLMELQEAVRW-----TEMIRASRENPAMQE------KKRSSIW 553
            +++A+ V    +Q ++    LQE  R      T++ +   E  ++Q+      + + ++ 
Sbjct: 1304 IKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLE 1363

Query: 554  QFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR----SSTLSQLPGDKSKAFDF 609
            +  S L    S++ KK      L+  A T       KKR       L+Q   +K+ A+D 
Sbjct: 1364 RHISTLNIQLSDSKKK------LQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417

Query: 610  LSEETEASLASRREQ---KREQYRQVKAHVQKED---GRVQAFGWSLPQKY-KQVTNGQG 662
            L E+T+  L    +      +  RQ+ ++++K+     ++ A   ++  KY  +    + 
Sbjct: 1418 L-EKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEA 1476

Query: 663  ENKMKNLPVPVYLRPLDEK-------DTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKD 715
            E + K        R L+E        + + K+  A   +L   K   G +V         
Sbjct: 1477 EAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNV--------- 1527

Query: 716  VAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEE 753
                  E  K + A ++ ++++  +L+E + EL+  E+
Sbjct: 1528 -----HELEKSKRALETQMEEMKTQLEELEDELQATED 1560



 Score = 50.8 bits (120), Expect = 8e-06
 Identities = 138/706 (19%), Positives = 275/706 (38%), Gaps = 114/706 (16%)

Query: 1    MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN 60
            ++LE+ +  +EE      +  E+V+  A     E E L+       + +   L+   + +
Sbjct: 953  LDLEEQL--EEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISD 1010

Query: 61   LDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            L +  A+++E    L  L++ +E +I++ E      + + ++  + +   E +  D   +
Sbjct: 1011 LTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 121  VESLESQTRQLELK-AKNYADQISRLEEREAELKKEYNALHQ-RHTE------------- 165
            +  L++Q  +L+++ AK   +  + L   + E+ ++ NAL + R  E             
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130

Query: 166  -MIHNYMEHLERTKLHQLSG-----SDQLESTA-HSRIRKERPISLGIFPLPAGDGLLTP 218
                N  E  +R    +L        D L+STA    +R +R   + +      +   + 
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 219  DA------QKGGE-----TPGSEQWKFQELSQPRSHTSLKVSNSP--------------- 252
            +A      QK  +     T   EQ+K  + +  ++  +L+  N+                
Sbjct: 1191 EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEV 1250

Query: 253  --EPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT-IPTDTPLKEENEG-FVKVT-DA 307
              + +K   Q  EL      G +A    +     +   + + T +  E EG  +K+  D 
Sbjct: 1251 EHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310

Query: 308  PNKSEISKHIEVQVAQETR---NVSTGSAE-NEEKSEVQAIIESTPELDMDKDLSGYKGS 363
             + S   +  +  + +ETR   NVST   +  EE++ +Q  ++   E++  ++L      
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDE--EMEAKQNL------ 1362

Query: 364  STPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMG-----REVENLILENT 418
                        +R+  +L  +LS +   L  D     + L  G     +E+ENL  +  
Sbjct: 1363 ------------ERHISTLNIQLSDSKKKL-QDFASTVEALEEGKKRFQKEIENLTQQYE 1409

Query: 419  QLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARA 478
            +     + L   KN L  ++D+L         +L+  +Q    LE+K R+ ++ L    A
Sbjct: 1410 EKAAAYDKLEKTKNRLQQELDDLVV-------DLDNQRQLVSNLEKKQRKFDQLL----A 1458

Query: 479  EAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRAS 538
            E ++   K  D+ D     A+ K    + +AR L E  + KE      E  R  +M++A 
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKE------ELERTNKMLKAE 1512

Query: 539  RENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQ 598
             E+    +           +  S  +  T+  E    L+        T   K R     Q
Sbjct: 1513 MEDLVSSKDDVGKNVHELEK--SKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQ 1570

Query: 599  LPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 644
                       L  + E  L +R EQ  E+ RQ++  + + +  ++
Sbjct: 1571 A----------LKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 116/596 (19%), Positives = 230/596 (38%), Gaps = 117/596 (19%)

Query: 33   REFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYERE 92
            +E E L  +Y+E+          A  + L+    + Q+   +L +  D+  QL++  E++
Sbjct: 1399 KEIENLTQQYEEKA---------AAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKK 1449

Query: 93   K-------ALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE--LKAKNYADQIS 143
            +       A  K+   K+ +  D  E E ++ +T+  SL    R LE  L+AK   ++ +
Sbjct: 1450 QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSL---ARALEEALEAKEELERTN 1506

Query: 144  RLEEREAE--------LKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSR 195
            ++ + E E        + K  + L ++    +   ME + +T+L +L   D+L++T  ++
Sbjct: 1507 KMLKAEMEDLVSSKDDVGKNVHEL-EKSKRALETQMEEM-KTQLEELE--DELQATEDAK 1562

Query: 196  IRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQ 255
            +R E         + A  G    D Q   E    ++ + Q                   +
Sbjct: 1563 LRLE-------VNMQALKGQFERDLQARDEQNEEKRRQLQ-------------------R 1596

Query: 256  KAVEQEDELSDVSQGGSKATTPASTANSDVATIP--TDTPLKEENEGFVKVTDAPNKSEI 313
            +  E E EL D  +  + A         D+  +    D+ +K   E   ++     + + 
Sbjct: 1597 QLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD 1656

Query: 314  SKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENK 373
             +  E++ A+ +R+    +A+  EK   +A       + + +DL+  + +         K
Sbjct: 1657 FQR-ELEDARASRDEIFATAKENEK---KAKSLEADLMQLQEDLAAAERA--------RK 1704

Query: 374  AFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKND 433
              D   E L EEL+S+ SG     DE        R +E  I +  + LE +       +D
Sbjct: 1705 QADLEKEELAEELASSLSGRNALQDEK-------RRLEARIAQLEEELEEEQGNMEAMSD 1757

Query: 434  LIAKV--------DELTCEKDVLQG--------------------ELEAVKQAKLK---- 461
             + K         +EL  E+   Q                     E+E   ++K K    
Sbjct: 1758 RVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIA 1817

Query: 462  -LEEKNRELEE----ELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERN 516
             LE K  +LEE    E R+ +A  +  +QK K   +  +     ++       +      
Sbjct: 1818 ALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNA 1877

Query: 517  QYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEP 572
            + K+   +L+EA   ++ I A+R     +  + +   +   R  ++  +  + P P
Sbjct: 1878 RVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRGPPP 1933


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 126/648 (19%), Positives = 251/648 (38%), Gaps = 92/648 (14%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYER----EKALRKHA 99
            E++VKE+  L  + +        + +E Q E E+L    E +  + ER     +A+R+  
Sbjct: 1584 EKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEK 1643

Query: 100  EE---KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEY 156
            +E   K    E ++++ +K LQ   + +E    ++   AK+   +I  LEE    L+ E 
Sbjct: 1644 QELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEV 1703

Query: 157  NALHQRHTEMIHNYM-------EHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPL 209
            +       E +   +       E LER K+   + S + +S                   
Sbjct: 1704 HPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLM----------------- 1746

Query: 210  PAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQ 269
                               SE+    E  Q   H      +     +A E+ D  ++V++
Sbjct: 1747 -------------------SEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNVTE 1787

Query: 270  GGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEV-QVAQETRNV 328
             G++ + P  T   D  ++ T  P   E+    K  +     + S H E+    Q+   +
Sbjct: 1788 EGTQ-SIPGETEEQDSLSMST-RPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQL 1845

Query: 329  STGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRN--TESLFEEL 386
                A  EE+ +       T E + +  LS         K ++ +    N   + + EEL
Sbjct: 1846 KERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEEL 1905

Query: 387  SSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKD 446
            S   + L    +E  D      ++E  ++   QL E   ++     D    V +   + +
Sbjct: 1906 SRV-TKLKETAEEEKD------DLEERLM--NQLAELNGSIGNYCQD----VTDAQIKNE 1952

Query: 447  VLQGELEAVKQAKLKLEEKNREL-------EEELRKARAEAEDARQKAKDDDDSDIPTAQ 499
            +L+ E++ +K+   +LEE+ ++L       E E+RK   E     QK   +        +
Sbjct: 1953 LLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQE 2012

Query: 500  RKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRA--------SREN--PAMQEKKR 549
              +  + E+ ++  +  +Y+E++  L+  V+  E ++         ++EN   A++ +K+
Sbjct: 2013 LLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKK 2072

Query: 550  SSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDF 609
            +       ++    + +        NLK          SVK   S + Q   D  +  + 
Sbjct: 2073 AQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVK---SQMKQKDEDLERRLE- 2128

Query: 610  LSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQV 657
             +EE         ++K +  R+ K H+++  G +Q    +L +K K+V
Sbjct: 2129 QAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQV---TLNKKDKEV 2173



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 92/441 (20%), Positives = 173/441 (39%), Gaps = 60/441 (13%)

Query: 64   VFAQDQEHQV---ELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTR 120
            V AQ++E       L LL+++ ++LIT+ +R     +           S E  K  L+  
Sbjct: 1527 VSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQ-------SLSSSCESLKLALEGL 1579

Query: 121  VESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH 180
             E  E   +++E    +   + +  +E+  EL+KEY  L Q + E + N  E ++    H
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSY-ENVSNEAERIQ----H 1634

Query: 181  QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP 240
             +    Q +   + ++R                   + +A K  ET    Q   QE+ + 
Sbjct: 1635 VVEAVRQEKQELYGKLR-------------------STEANKK-ETEKQLQEAEQEMEEM 1674

Query: 241  RSHTSLKVSNSPEPQKAVEQEDE----LSDVSQGGSKATTPASTANSDVATIPTDTP-LK 295
            +    ++     + QK +E E+E     ++V   G  A     T  S  A++  +   +K
Sbjct: 1675 KE--KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVK 1732

Query: 296  EENEGFVKVTDA--PNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDM 353
             E E   K   +    K  +S+ ++    Q   NVS            QA +E+T + D 
Sbjct: 1733 MEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK-----------QANLEATEKHDN 1781

Query: 354  DKDLSGYKGSSTPTKGIENKAFDRNTESLFEE----LSSAGSGLIGDVDEGADLLGMGRE 409
              +++     S P +  E  +   +T     E      SA   +  D     ++    ++
Sbjct: 1782 QTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQ 1841

Query: 410  VENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 469
            ++ L      L E K         L  + + L  +     GEL+ +++   K+   N+++
Sbjct: 1842 IDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQI 1901

Query: 470  EEELRKARAEAEDARQKAKDD 490
            +EEL +     E A ++ KDD
Sbjct: 1902 QEELSRVTKLKETAEEE-KDD 1921



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 104/494 (21%), Positives = 190/494 (38%), Gaps = 76/494 (15%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQ 118
            ENLDS   Q       +  L+DD +++I +        K  E KF +   S+E+E +  +
Sbjct: 2178 ENLDSTVTQLAAFTKSMSSLQDDRDRVIDE-------AKKWERKFSDAIQSKEEEIRLKE 2230

Query: 119  TRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTK 178
                 L+ Q RQ+ +  +     ISRLE      K+ + +  Q   ++     + L+   
Sbjct: 2231 DNCSVLKDQLRQMSIHMEELKINISRLEHD----KQIWESKAQTEVQLQQKVCDTLQGEN 2286

Query: 179  LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELS 238
               LS   QLE T H                      L   +Q       +E  K +   
Sbjct: 2287 KELLS---QLEETRH----------------------LYHSSQ-------NELAKLESEL 2314

Query: 239  QPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEEN 298
            +        +SNS E  K  EQ+  L  + +        A   NS  +    +T L+   
Sbjct: 2315 KSLKDQLTDLSNSLE--KCKEQKGNLEGIIR-----QQEADIQNSKFSYEQLETDLQASR 2367

Query: 299  EGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLS 358
            E   ++ +  N  E      +   +E   V+      +   E++         +++  LS
Sbjct: 2368 ELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIK---------ELENLLS 2418

Query: 359  GYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLI---GDVDEGADLLGMGREVENLIL 415
              +  +   +    KA D+ T  L E L +     I     +D     +   +   + I+
Sbjct: 2419 QEEEENIVLEEENKKAVDK-TNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIV 2477

Query: 416  ENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRK 475
             + Q LE ++   I++ D +  + E   E + L+ E+  ++     L  +N +L+ EL +
Sbjct: 2478 GDYQQLEERHLSIILEKDQL--IQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQ 2535

Query: 476  ARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMI 535
             R   ED  Q         I  +Q+K+   V++ +     N+Y +   +L+E+    E +
Sbjct: 2536 YR---EDLNQVI------TIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDL 2586

Query: 536  RASRENPAMQEKKR 549
            R  R   A+QE+K+
Sbjct: 2587 R--RSFNALQEEKQ 2598



 Score = 47.4 bits (111), Expect = 9e-05
 Identities = 125/670 (18%), Positives = 232/670 (34%), Gaps = 119/670 (17%)

Query: 83  EQLITQYEREKALRKHAEEKFIE---FEDSQEQEKKDLQTRVESLESQTRQLELKAKNYA 139
           ++L    +R + L +  ++   E     ++ E E+++ +  +E +E +  + +L   N  
Sbjct: 280 QELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKLSFHNLQ 339

Query: 140 DQISRLEER-------EAELKKEYNALHQRHTEMIHNYMEH---LERTKLHQLSGSDQLE 189
           +++  L E+       +AEL+  Y+AL Q+H   +     H   L++T     S  D L+
Sbjct: 340 EEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALK 399

Query: 190 STAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVS 249
                                    LL    ++  ++  + Q    +L Q     S  ++
Sbjct: 400 D--------------------QNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLN 439

Query: 250 NSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDT-------------PLKE 296
             P  Q     +    DV   G++A T  + A+     +  +               LK 
Sbjct: 440 RLPLQQHETASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKA 499

Query: 297 ENEGF----------------------VKVTDAPNKSEISKH------IEVQVAQETRNV 328
           ENE                        + + D  NK   S        +E   +Q+ + +
Sbjct: 500 ENEKLSSQITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKEL 559

Query: 329 STGSAENEEKSEVQAII----------ESTPELDMDKDLSGYKGSSTPTKGIENKAFDRN 378
           S    E +E  E  A +          E+  E+   K++   +G       I+ K F  +
Sbjct: 560 SVLLLEMKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAP--IKMKVFLED 617

Query: 379 TESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKV 438
           T   F  + +  S L     E A      R  E + L N   +E K+        L A  
Sbjct: 618 TGQDFPLMPNEESSLPAVEKEQASTEHQSRTSEEISL-NDAGVELKSTKQDGDKSLSAVP 676

Query: 439 DELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQ-----KAKDDDDS 493
           D   C +D L+     + + +L   +     E+ L +   E  +  Q     K   D++S
Sbjct: 677 DIGQCHQDELERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNS 736

Query: 494 DIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIW 553
              TA  +            ER+Q   ++ EL         ++    N A  E++R   +
Sbjct: 737 SAFTALSE------------ERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDY 784

Query: 554 QFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEE 613
           +      S +++     E   +L   A +  V   V +      QL         F  + 
Sbjct: 785 E------SQTAHDNLLTEQIHSLSIEAKSKDVKIEVLQNELDDVQL--------QFSEQS 830

Query: 614 T-EASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVP 672
           T   SL S+ + K  +  +    V+    +V+    +L QK  ++T        K   V 
Sbjct: 831 TLIRSLQSQLQNKESEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLLLEKKRDVE 890

Query: 673 VYLRPLDEKD 682
              + ++EKD
Sbjct: 891 TLQQTIEEKD 900



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 157/783 (20%), Positives = 282/783 (36%), Gaps = 166/783 (21%)

Query: 100  EEKFIEFEDSQEQEKKDLQTRVES-------LESQTRQLELKAKNYADQISRLEEREAEL 152
            EEK +  E  +EQ +K LQ  + S        + + R L  + K   D  +RL+E+  E 
Sbjct: 1163 EEKILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQ 1222

Query: 153  KKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGI---FPL 209
             KE   +  +  ++     E ++     +L  +DQ ES + S    E P+          
Sbjct: 1223 SKENENIGDQLRQLQIQVRESID----GKLPSTDQQESCS-STPGLEEPLFKATEQHHTQ 1277

Query: 210  PAGDGLLTPD---------AQKGGETPGSEQWKFQELSQPRSHTSLKVSNSP-------- 252
            P  +  L PD         A +GG +    + + +E+   +    LKVS++         
Sbjct: 1278 PVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSE 1337

Query: 253  ----------------EPQKAVEQEDE----------------------LSDVSQGGSKA 274
                            E  K V  E E                      L ++     + 
Sbjct: 1338 EVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDEL 1397

Query: 275  TTPASTANSDVATIPTDTPLKE-----------ENEGFVKVTDAPNKSEISKH------I 317
                S    DV+ +      KE           E E  +K      + +  +H      +
Sbjct: 1398 QKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQL 1457

Query: 318  EVQVAQETRNVSTGSAENEEKSEVQ-----AIIESTPELDMDKDLSGYKGSSTPTKGIEN 372
            +V++ +  +       E+  K ++Q     A+I     L  +K L             E 
Sbjct: 1458 QVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQ------------EE 1505

Query: 373  KAFDRNT-ESLFEELSSAGSGLIGDVDEGADLLG----MGREVENLILENTQLLETKNAL 427
             +  R T E L + L+   S +     E   +LG    +  E + LI E  + L    +L
Sbjct: 1506 LSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSL 1565

Query: 428  NIVKNDLIAKVDELTCEKDVLQGELEAVKQAKL----KLEEKNRELEEELRKARAEAEDA 483
            +     L   ++ LT +K+ L  E+E++K +K+    + +EK++EL++E        E+ 
Sbjct: 1566 SSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENV 1625

Query: 484  RQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPA 543
              +A+          Q K+    ++      + + +++L E ++ +   EM    R+   
Sbjct: 1626 SNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEME--EMKEKMRKFAK 1683

Query: 544  MQEKKRSSIWQFFSRLFSS--SSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPG 601
             +++K   + +   RL +    +  T K      L  NA        VK    TL     
Sbjct: 1684 SKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETL----- 1738

Query: 602  DKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQ 661
              SK F  L  E +    S  E+ ++   Q++ +V K+   ++A      +K+   TN  
Sbjct: 1739 --SKKFQSLMSEKD----SLSEEVQDLKHQIEGNVSKQ-ANLEA-----TEKHDNQTNVT 1786

Query: 662  GENKMKNLPVPVYLRPLDEKDTSMKLWCAVGV----NLSGGKTRDGGSVVGASVFYKD-- 715
             E       +P      D    S +  C+  V    + +   ++D  S    + + +   
Sbjct: 1787 EEGTQS---IPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQID 1843

Query: 716  -----VAGLDTEGSKQRSASQ----------SSLDKLDQELKEQQKELKN--------QE 752
                 +AGL+ E  K +  SQ          S +   D ELK  Q+E+          QE
Sbjct: 1844 QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQE 1903

Query: 753  ELS 755
            ELS
Sbjct: 1904 ELS 1906



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 120/650 (18%), Positives = 257/650 (39%), Gaps = 87/650 (13%)

Query: 30   SIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQY 89
            S+  + +R++G Y +++ +  + +++   + +    A++ + + E+  LR   + L ++ 
Sbjct: 2468 SLQNDRDRIVGDY-QQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSEN 2526

Query: 90   EREKA-LRKHAEE--KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLE 146
             +  A L ++ E+  + I  +DSQ+++  ++Q +      Q ++LE K     +++   E
Sbjct: 2527 AKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQ------QNKELENKYAKLEEKLKESE 2580

Query: 147  EREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGI 206
            E   +L++ +NAL +   ++     + +E  K+     + Q+     + +++E  + L  
Sbjct: 2581 EANEDLRRSFNALQEEKQDL----SKEIESLKVSISQLTRQV-----TALQEEGTLGLYH 2631

Query: 207  FPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQED---- 262
              L   +     +  +      S Q +  EL +      L        +K  E ED    
Sbjct: 2632 AQLKVKE----EEVHRLSALFSSSQKRIAELEE-----ELVCVQKEAAKKVGEIEDKLKK 2682

Query: 263  ELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVA 322
            EL  +            TA   VA +  D  L E  +  + VT      + +K +  Q+ 
Sbjct: 2683 ELKHLHHDAGIMRNETETAEERVAELARD--LVEMEQKLLMVT------KENKGLTAQIQ 2734

Query: 323  QETRNVSTGSAENEEKSEVQAIIESTPELDMD-KDLSGYKGSSTPTKGIENKAFDRNTES 381
               R++S  S +N      + + E   + D   K+L+  K         E    +R  ++
Sbjct: 2735 SFGRSMS--SLQNSRDHANEELDELKRKYDASLKELAQLK---------EQGLLNRERDA 2783

Query: 382  LFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIA---KV 438
            L  E + + +       E   L  + +  + L+ ++ QLL   + L    N + +    +
Sbjct: 2784 LLSETAFSMNS-----TEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAM 2838

Query: 439  DELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAED---ARQKAKDDDDSDI 495
              L  E+D L  ELE  +    K EE  +    +   + AE +    A    ++D D  +
Sbjct: 2839 ASLQNERDHLWNELEKFR----KSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLL 2894

Query: 496  PTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRAS--RENPAMQE-----KK 548
               +  +   +++ + + E +  K +L E Q+  +  ++++    +EN + Q      + 
Sbjct: 2895 KELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLRM 2954

Query: 549  RSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFD 608
              S W+   R            +       +   SH+   +++  S+ SQ    K +   
Sbjct: 2955 EKSSWEIHERRMKEQYLMAISDK-------DQQLSHLQNLIRELRSSSSQTQPLKVQYQR 3007

Query: 609  FLSEETEAS------LASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQ 652
              S ET AS      L    E  R Q       + +++ R+Q    +  Q
Sbjct: 3008 QASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRIQQLNSNFSQ 3057



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 119/637 (18%), Positives = 254/637 (39%), Gaps = 78/637 (12%)

Query: 20   MSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLR 79
            + ER++GL      E E+   +   + ++     +++ +   D      QE   ++ LL 
Sbjct: 1845 LKERIAGL------EEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLL- 1897

Query: 80   DDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYA 139
              N+Q+  +  R   L++ AEE           EK DL+   E L +Q  +L     NY 
Sbjct: 1898 --NQQIQEELSRVTKLKETAEE-----------EKDDLE---ERLMNQLAELNGSIGNYC 1941

Query: 140  DQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKE 199
              ++     +A++K   N L +   + +   +  LE  K   +    ++E    S IRKE
Sbjct: 1942 QDVT-----DAQIK---NELLESEMKNLKKCVSELEEEKQQLVKEKTKVE----SEIRKE 1989

Query: 200  RPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAV- 258
                +       G+     + Q   E    +Q + ++L +       K+S      KA+ 
Sbjct: 1990 YLEKIQGAQKEPGNKSHAKELQ---ELLKEKQQEVKQLQKDCIRYQEKISALERTVKALE 2046

Query: 259  ----EQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS 314
                E + +L    +  ++A      A +++A+        +     V   +   K E+ 
Sbjct: 2047 FVQTESQKDLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQ 2106

Query: 315  KH---IEVQVAQETRNVSTGSAENEEK--SEVQAIIESTPELDMDK-DLSGYKGSSTPTK 368
             +   ++ Q+ Q+  ++     + EEK   E + + E    L  +K  L    G    T 
Sbjct: 2107 SNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTL 2166

Query: 369  GIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETK--NA 426
               NK  D+  + L E L S  + L       + L    ++  + +++  +  E K  +A
Sbjct: 2167 ---NKK-DKEVQQLQENLDSTVTQLAAFTKSMSSL----QDDRDRVIDEAKKWERKFSDA 2218

Query: 427  LNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAE-DARQ 485
            +   + ++  K D  +  KD L+    ++   +LK+     E ++++ +++A+ E   +Q
Sbjct: 2219 IQSKEEEIRLKEDNCSVLKDQLR--QMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQ 2276

Query: 486  KAKD---DDDSDI-----PTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRA 537
            K  D    ++ ++      T      ++ E+A++  E    K++L +L  ++   +  + 
Sbjct: 2277 KVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKG 2336

Query: 538  SRENPAMQEKKRSSIWQF-FSRL---FSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRS 593
            + E    Q++      +F + +L     +S   T +    +N+K     S ++   +   
Sbjct: 2337 NLEGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQ 2396

Query: 594  STLSQLPGDKSKAF----DFLSEETEASLASRREQKR 626
              +++L     K      + LS+E E ++    E K+
Sbjct: 2397 VAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKK 2433



 Score = 34.3 bits (77), Expect = 0.81
 Identities = 119/644 (18%), Positives = 232/644 (36%), Gaps = 91/644 (14%)

Query: 74   ELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL--ESQTRQL 131
            +L LL    E    Q E +  +    ++ + E   + +  K++LQ   + L  E++ R+ 
Sbjct: 934  QLNLLSRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKR 993

Query: 132  ELKA-----KNYADQISRLEEREAELKKEYN---ALHQRHTEMIHNYMEHLERTKLHQLS 183
            +L+A     K    ++SRLEE  A LK E      L +     +    E+ E ++    S
Sbjct: 994  KLQAALINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTS 1053

Query: 184  GSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSH 243
               ++E      I  E+ + L                +K  E   + + +FQ L +  + 
Sbjct: 1054 KCQEIEIYLKQTI-SEKEVEL-------------QHIRKDLEEKLAAEEQFQALVKQMNQ 1099

Query: 244  TSLKVSNSPEPQKAVEQEDEL---------SDVSQGGSKATTPASTANSDVATIPTDTPL 294
            T    +N  +  +A   E++          +D S G S A    +   S   T  ++   
Sbjct: 1100 TLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWK 1159

Query: 295  KEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD 354
             E  E  + +     K ++ K  ++Q A  +R      A+ +E+           EL   
Sbjct: 1160 PELEEKILAL--EKEKEQLQK--KLQEALTSRKAILKKAQEKER-------HLREELKQQ 1208

Query: 355  KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLI 414
            KD           +  EN+        L  ++  +  G +   D+           E L 
Sbjct: 1209 KDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLF 1268

Query: 415  LENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQG---------ELEAVKQAKLKLEEK 465
                +  E  +   +++++L       + +   LQG         +L+ ++  K++LE K
Sbjct: 1269 ----KATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELK 1324

Query: 466  NRELEEELRKARAEAEDARQKAKDD--DDSDIPTAQRKRFTRVEMARVLMERNQYK---- 519
                  EL K   E    +++      +   + T   +     E  +  +E +Q +    
Sbjct: 1325 VSSTTSELTKKSEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGL 1384

Query: 520  ERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLK-- 577
            E L ELQ  +          E   +  KK   +     +L    +  TK     +  +  
Sbjct: 1385 EHLRELQPKL---------DELQKLISKKEEDVSYLSGQLSEKEAALTKIQTEIIEQEDL 1435

Query: 578  YNAPTSHVTPSVKKRSSTLSQLP-------------GDKSKAFDFLSEETEASLASRREQ 624
              A  + +    K+    + QL              G++S+A   +  + +A+L SR+E 
Sbjct: 1436 IKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEA 1495

Query: 625  KREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKN 668
             +E  + ++  +    G ++    SL     QV+    +NK K+
Sbjct: 1496 LKEN-KSLQEELSLARGTIERLTKSLADVESQVS---AQNKEKD 1535


>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
            sapiens]
          Length = 1939

 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 150/738 (20%), Positives = 291/738 (39%), Gaps = 119/738 (16%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVES-----L 124
            E + E+  ++++ E+   +  + +A RK  EEK +       QEK DLQ +V++      
Sbjct: 848  ETEKEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLM----QEKNDLQLQVQAEADALA 903

Query: 125  ESQTR---------QLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            +++ R         QLE K K   ++    EE  AEL  +   L    +E+  + ++ LE
Sbjct: 904  DAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD-IDDLE 962

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
             T         ++E   H+   K + ++  +  L      LT + +K  +    +     
Sbjct: 963  LTLA-------KVEKEKHATENKVKNLTEEMAGLDETIAKLTKE-KKALQEAHQQTLDDL 1014

Query: 236  ELSQPRSHTSLKVSNSPEPQ-----KAVEQEDEL-SDVSQGGSKATTPASTANSDVATIP 289
            ++ + + +T  K     E Q      ++EQE +L  D+ +   K       A    +T+ 
Sbjct: 1015 QMEEDKVNTLTKAKTKLEQQVDDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQE--STMD 1072

Query: 290  TDTPLKEENEGFVK----VTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAII 345
            T+   ++ NE   K    +++   K E  + + +Q+ ++ + +     E EE+ E +   
Sbjct: 1073 TENDKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERAS 1132

Query: 346  ESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVD----EGA 401
             +  E     DLS                  R  E + E L  AG      ++      A
Sbjct: 1133 RAKAE-KQRSDLS------------------RELEEISERLEEAGGATSAQIEMNKKREA 1173

Query: 402  DLLGMGREVENLILEN---------------TQLLETKNALNIVKNDLIAKVDELTCEKD 446
            +   M R++E   L++                +L E  ++L  VK  L  +  EL  E +
Sbjct: 1174 EFQKMRRDLEESTLQHEATAAALRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEIN 1233

Query: 447  VLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRF--T 504
             L   +E V +AK   E+  R LE++L + + + E+ ++   +       +AQ+ R    
Sbjct: 1234 DLASNMETVSKAKANFEKMCRTLEDQLSEIKTKEEEQQRLINE------LSAQKARLHTE 1287

Query: 505  RVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSS 564
              E +R L E++    +L   ++A  +T+ I   +     + K +S++            
Sbjct: 1288 SGEFSRQLDEKDAMVSQLSRGKQA--FTQQIEELKRQLEEETKAKSTLAHALQSARHDCD 1345

Query: 565  NTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQ 624
               ++ E     K     + +   + K +S ++Q              + E     R E+
Sbjct: 1346 LLREQYEEEQEAK-----AELQRGMSKANSEVAQ-----------WRTKYETDAIQRTEE 1389

Query: 625  KREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLR-----PLD 679
              E  +++   +Q  +  V+A         K  T  + +N++++L + V         LD
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNSKCASLEK--TKQRLQNEVEDLMIDVERSNAACIALD 1447

Query: 680  EKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQ 739
            +K  +          L+  K +   +        K+   L TE  K ++A + SLD L +
Sbjct: 1448 KKQRNF------DKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHL-E 1500

Query: 740  ELKEQQKELKNQEELSSL 757
             LK + K L  Q+E+S L
Sbjct: 1501 TLKRENKNL--QQEISDL 1516



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 101/474 (21%), Positives = 189/474 (39%), Gaps = 91/474 (19%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKF 103
            EE  K+L   +    E++++V ++    +   + L+++ E L+   ER  A     ++K 
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVEDLMIDVERSNAACIALDKKQ 1450

Query: 104  IEFED---SQEQEKKDLQTRVESLESQTRQLE---LKAKN-YADQISRLEEREAELKKEY 156
              F+      +Q+ ++ Q  +E+ + ++R L     K KN Y + +  LE     LK+E 
Sbjct: 1451 RNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLET----LKREN 1506

Query: 157  NALHQRHTEMIHNYMEHLERTKLHQLSG-SDQLESTAHSRIRKERPISLGIFPLPAGDGL 215
              L Q  +++     E  +   +H+L     QL+       + E   SL           
Sbjct: 1507 KNLQQEISDLTEQIAEGGKH--IHELEKVKKQLDHE-----KSELQTSL----------- 1548

Query: 216  LTPDAQKGGETPGSEQWKFQ-ELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKA 274
               +A+   E    +  + Q EL+Q +S    K++         E+++EL  + +   + 
Sbjct: 1549 --EEAEASLEHEEGKILRIQLELNQVKSEIDRKIA---------EKDEELDQLKRNHLRV 1597

Query: 275  T-TPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS-KHIEVQVAQETRNVSTGS 332
              +  ST ++++ +      +K++ EG +      N+ EI   H   Q A+  RN+    
Sbjct: 1598 VESMQSTLDAEIRSRNDALRIKKKMEGDL------NEMEIQLNHANRQAAEALRNLRN-- 1649

Query: 333  AENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKA--FDRNTESLFEELSSAG 390
                     Q I++ T +L +D  + G          +E +A       E L   L    
Sbjct: 1650 --------TQGILKDT-QLHLDDAIRGQDDLKEQLAMVERRANLMQAEVEELRASLERTE 1700

Query: 391  SGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDV--L 448
             G      E   LL     V+ L  +NT L+ TK  L                E D+  +
Sbjct: 1701 RGRKMAEQE---LLDASERVQLLHTQNTSLINTKKKL----------------ETDISQI 1741

Query: 449  QGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKR 502
            QGE+E + Q       + R  EE+ +KA  +A    ++ K + D+     + K+
Sbjct: 1742 QGEMEDIVQ-------EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 106/493 (21%), Positives = 195/493 (39%), Gaps = 95/493 (19%)

Query: 60   NLDSVFAQ----DQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKK 115
            N D V A+     +E Q ELE  + ++  L T+  + K    +A E+ ++  ++ ++E K
Sbjct: 1452 NFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVK----NAYEESLDHLETLKRENK 1507

Query: 116  DLQTRVESLESQT-------RQLELKAKNYADQISRL----EEREAELKKEYNALHQRHT 164
            +LQ  +  L  Q         +LE   K    + S L    EE EA L+ E   + +   
Sbjct: 1508 NLQQEISDLTEQIAEGGKHIHELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQL 1567

Query: 165  EM----------IHNYMEHLERTKLHQLSGSDQLESTAHSRIRK---------------- 198
            E+          I    E L++ K + L   + ++ST  + IR                 
Sbjct: 1568 ELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLN 1627

Query: 199  ERPISLGIFPLPAGDGLLTPDAQKG----------GETPGSEQWKFQELSQPRSHTSLKV 248
            E  I L      A + L      +G              G +  K ++L+      +L  
Sbjct: 1628 EMEIQLNHANRQAAEALRNLRNTQGILKDTQLHLDDAIRGQDDLK-EQLAMVERRANLMQ 1686

Query: 249  SNSPEPQKAVEQ--------EDELSDVSQGGSKATTPASTANSDVATIPTD-TPLKEENE 299
            +   E + ++E+        E EL D S+      T  ++  +    + TD + ++ E E
Sbjct: 1687 AEVEELRASLERTERGRKMAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEME 1746

Query: 300  GFVKVTDAPNKSEISKHI---EVQVAQETRNVSTGSA--ENEEKSEVQAIIESTPELDMD 354
              V+  +A N  E +K        +A+E +     SA  E  +K+  Q + +    LD  
Sbjct: 1747 DIVQ--EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEA 1804

Query: 355  KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLI 414
            + L+  KG     + +E +  +  +E   E+  +        V+    L    R V+ L 
Sbjct: 1805 EQLA-LKGGKKQIQKLEARVRELESEVESEQKHN--------VEAVKGLRKHERRVKELT 1855

Query: 415  LENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELR 474
             +  +  + KN L +   DL+          D LQ +++A K+   + EE++     + R
Sbjct: 1856 YQTEE--DRKNILRL--QDLV----------DKLQTKVKAYKRQAEEAEEQSNVNLAKFR 1901

Query: 475  KARAEAEDARQKA 487
            K + E E+A+++A
Sbjct: 1902 KLQHELEEAKERA 1914



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 104/525 (19%), Positives = 198/525 (37%), Gaps = 85/525 (16%)

Query: 43   DEEVVKELMPLVVAVLENLDSVFAQDQEHQVELEL----LRDDNEQLITQYEREKALRKH 98
            D++ + E +      + NL      +Q   ++L+     L+   E+L  + E E+A R  
Sbjct: 1076 DKQQLNEKLKKKEFEMSNLQGKIEDEQALAIQLQKKIKELQARIEELEEEIEAERASRAK 1135

Query: 99   AEEKFIEFE---------------------DSQEQEKKDLQTRVESLESQTRQLELKA-- 135
            AE++  +                       +  ++ + + Q     LE  T Q E  A  
Sbjct: 1136 AEKQRSDLSRELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAA 1195

Query: 136  --KNYADQISRLEER-------EAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
              K +AD ++ L E+       + +L+KE + L     ++  N ME + + K +      
Sbjct: 1196 LRKKHADSVAELGEQIDSLQRVKQKLEKEKSELKMEINDLASN-METVSKAKANFEKMCR 1254

Query: 187  QLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSL 246
             LE        KE      I  L A    L  ++ +       +     +LS+ +   + 
Sbjct: 1255 TLEDQLSEIKTKEEEQQRLINELSAQKARLHTESGEFSRQLDEKDAMVSQLSRGKQAFTQ 1314

Query: 247  KVSNSPEPQKAVEQE----------------------DELSDVSQGGSKATTPASTANSD 284
            ++    E ++ +E+E                      ++  +  +  ++     S ANS+
Sbjct: 1315 QIE---ELKRQLEEETKAKSTLAHALQSARHDCDLLREQYEEEQEAKAELQRGMSKANSE 1371

Query: 285  VA----TIPTDTPLKEENEGFVKVTDAPNKSEISKHIEV---------QVAQETRNVSTG 331
            VA       TD   + E     K   A    +  +H+E          +  Q  +N    
Sbjct: 1372 VAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEVED 1431

Query: 332  SAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGS 391
               + E+S    I     + + DK L+ +K     T+  E +A  + + SL  EL    +
Sbjct: 1432 LMIDVERSNAACIALDKKQRNFDKVLAEWKQKYEETQA-ELEASQKESRSLSTELFKVKN 1490

Query: 392  GLIGDVDEGADLLGMGREVENLILENTQLLE--TKNALNIVKNDLIAKVDELTCEKDVLQ 449
                 +D    L  + RE +NL  E + L E   +   +I + + + K  +L  EK  LQ
Sbjct: 1491 AYEESLDH---LETLKRENKNLQQEISDLTEQIAEGGKHIHELEKVKK--QLDHEKSELQ 1545

Query: 450  GELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSD 494
              LE  + +    E K   ++ EL + ++E +  R+ A+ D++ D
Sbjct: 1546 TSLEEAEASLEHEEGKILRIQLELNQVKSEID--RKIAEKDEELD 1588


>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 149/728 (20%), Positives = 287/728 (39%), Gaps = 99/728 (13%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFI----EFEDSQEQEKK------DLQT 119
            E + E+  ++++ +++  +  + +A RK  EEK +    E  D Q Q +       D + 
Sbjct: 850  ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909

Query: 120  RVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKL 179
            R + L     QLE K K   ++    EE  AEL  +   L    +E+  + ++ LE T  
Sbjct: 910  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD-IDDLELTLA 968

Query: 180  HQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQ 239
                     E+   +   +   +   I  L      L    Q+  +   +E+ K   L++
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028

Query: 240  PRSHTSLKVSNSPEPQKAVEQEDEL-SDVSQGGSKATTPASTANSDVATIPTDTPLKEE- 297
             +     +V    + + ++EQE +L  D+ +   K       A   +  I  +    +E 
Sbjct: 1029 AKIKLEQQVD---DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085

Query: 298  -NEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKD 356
              +   ++++  +K E  + + +Q+ ++ + +     E EE+ E +    +  E     D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE-KQRSD 1144

Query: 357  LSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVD----EGADLLGMGREVEN 412
            LS                  R  E + E L  AG      ++      A+   M R++E 
Sbjct: 1145 LS------------------RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186

Query: 413  LILEN---------------TQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQ 457
              L++                +L E  + L  VK  L  +  E+  E D L   +E V +
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246

Query: 458  AKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRV--EMARVLMER 515
            AK  LE+  R LE++L + +++ E+ ++   D       TAQR R      E +R L E+
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLIND------LTAQRGRLQTESGEFSRQLDEK 1300

Query: 516  NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVN 575
                 +L   ++A  +T+ I   +     + K ++++    +    SS +          
Sbjct: 1301 EALVSQLSRGKQA--FTQQIEELKRQLEEEIKAKNAL----AHALQSSRH---------- 1344

Query: 576  LKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSE---ETEASLASRREQKREQYRQV 632
                     +    ++   + ++L    SKA   +++   + E     R E+  E  +++
Sbjct: 1345 -----DCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399

Query: 633  KAHVQKEDGRVQAFGWSLP--QKYKQVTNGQGENKMKNLP-VPVYLRPLDEKDTSMKLWC 689
               +Q  +  V+A        +K KQ    + E+ M ++         LD+K  +     
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459

Query: 690  AVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELK 749
            A        K  +  + + AS   K+   L TE  K ++A + SLD+L + LK + K L 
Sbjct: 1460 AEWKQ----KCEETHAELEAS--QKEARSLGTELFKIKNAYEESLDQL-ETLKRENKNL- 1511

Query: 750  NQEELSSL 757
             Q+E+S L
Sbjct: 1512 -QQEISDL 1518



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 101/476 (21%), Positives = 193/476 (40%), Gaps = 95/476 (19%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKF 103
            EE  K+L   + A  E++++V A+    +   + L+++ E L+   ER  A     ++K 
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452

Query: 104  IEFED---SQEQEKKDLQTRVESLESQTRQLE---LKAKN-YADQISRLEEREAELKKEY 156
              F+      +Q+ ++    +E+ + + R L     K KN Y + + +LE     LK+E 
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET----LKREN 1508

Query: 157  NALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLL 216
              L Q  +++     E  +R  +H+L            +I+K+  +      L A     
Sbjct: 1509 KNLQQEISDLTEQIAEGGKR--IHELE-----------KIKKQ--VEQEKCELQAA---- 1549

Query: 217  TPDAQKGGETPGSEQWKFQ-ELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKAT 275
              +A+   E    +  + Q EL+Q +S    K++         E+++E+  + +   +  
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA---------EKDEEIDQLKRNHIRIV 1600

Query: 276  -TPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS-KHIEVQVAQETRNVSTGSA 333
             +  ST ++++ +      LK++ EG +      N+ EI   H     A+  RN      
Sbjct: 1601 ESMQSTLDAEIRSRNDAIRLKKKMEGDL------NEMEIQLNHANRMAAEALRNYRN--- 1651

Query: 334  ENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSA---- 389
                    Q I++ T ++ +D  L   +        +E +A     E   EEL +     
Sbjct: 1652 -------TQGILKDT-QIHLDDALRSQEDLKEQLAMVERRANLLQAE--IEELRATLEQT 1701

Query: 390  -GSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDV- 447
              S  I +     +LL     V+ L  +NT L+ TK  L                E D+ 
Sbjct: 1702 ERSRKIAE----QELLDASERVQLLHTQNTSLINTKKKL----------------ETDIS 1741

Query: 448  -LQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKR 502
             +QGE+E + Q       + R  EE+ +KA  +A    ++ K + D+     + K+
Sbjct: 1742 QMQGEMEDILQ-------EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1790



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 94/452 (20%), Positives = 185/452 (40%), Gaps = 63/452 (13%)

Query: 69   QEHQVELELLRDDNEQL------ITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVE 122
            +E   +LE L+ +N+ L      +T+   E   R H  EK    +   EQEK +LQ  +E
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI---KKQVEQEKCELQAALE 1551

Query: 123  SLESQTRQLE---LKAKNYADQI-SRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTK 178
              E+     E   L+ +   +Q+ S ++ + AE  +E + L + H  ++ +    L+  +
Sbjct: 1552 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD-AE 1610

Query: 179  LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKG---------GETPGS 229
            +   + + +L+      +  E  I L      A + L      +G          +   S
Sbjct: 1611 IRSRNDAIRLKKKMEGDLN-EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRS 1669

Query: 230  EQWKFQELSQPRSHTSLKVSNSPEPQKAVEQ--------EDELSDVSQGGSKATTPASTA 281
            ++   ++L+      +L  +   E +  +EQ        E EL D S+      T  ++ 
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1729

Query: 282  NSDVATIPTD-TPLKEENEGFVKVTDAPNKSEISKHI---EVQVAQETRNVSTGSA--EN 335
             +    + TD + ++ E E  ++  +A N  E +K        +A+E +     SA  E 
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQ--EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787

Query: 336  EEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIG 395
             +K+  Q + +    LD  + L+  KG     + +E +  +   E   E+  +A      
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLA-LKGGKKQIQKLEARVRELEGEVESEQKRNA------ 1840

Query: 396  DVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 455
              +    L    R V+ L  +  +  + KN L +   DL+          D LQ ++++ 
Sbjct: 1841 --EAVKGLRKHERRVKELTYQTEE--DRKNILRL--QDLV----------DKLQAKVKSY 1884

Query: 456  KQAKLKLEEKNRELEEELRKARAEAEDARQKA 487
            K+   + EE++     + RK + E E+A ++A
Sbjct: 1885 KRQAEEAEEQSNTNLAKFRKLQHELEEAEERA 1916



 Score = 37.4 bits (85), Expect = 0.096
 Identities = 161/825 (19%), Positives = 297/825 (36%), Gaps = 167/825 (20%)

Query: 58   LENLDSVFAQDQEHQVELEL----LRDDNEQLITQYEREKALRKHAEEKFIEFE------ 107
            + NL S    +Q   ++L+     L+   E+L  + E E+A R  AE++  +        
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152

Query: 108  ---------------DSQEQEKKDLQTRVESLESQTRQLELKA----KNYADQISRLEER 148
                           +  ++ + + Q     LE  T Q E  A    K +AD ++ L E+
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212

Query: 149  EAELKKEYNALHQRHTEM------IHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPI 202
               L++    L +  +EM      + + +E + + K +       LE        KE   
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQ 1272

Query: 203  SLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQE- 261
               I  L A  G L  ++ +       ++    +LS+ +   + ++    E ++ +E+E 
Sbjct: 1273 QRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIE---ELKRQLEEEI 1329

Query: 262  ---------------------DELSDVSQGGSKATTPASTANSDVA----TIPTDTPLKE 296
                                 ++  +  +  ++     S AN++VA       TD   + 
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 297  ENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIEST-------- 348
            E     K   A       +H+E   A+      T      E  ++   +E T        
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449

Query: 349  -PELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMG 407
              + + DK L+ +K     T   E +A  +   SL  EL    +     +D+   L  + 
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHA-ELEASQKEARSLGTELFKIKNAYEESLDQ---LETLK 1505

Query: 408  REVENLILENTQLLE--TKNALNIVKNDLIAK-VDELTCEKDVLQGELEA---------- 454
            RE +NL  E + L E   +    I + + I K V++  CE      E EA          
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL 1565

Query: 455  -----VKQAKLKLEEKNRELEEEL-------------------RKARAEAEDARQKAKDD 490
                 + Q K +++ K  E +EE+                    + R+  +  R K K +
Sbjct: 1566 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625

Query: 491  DDSDIPTAQRKRFTRVEMARVLMERNQ---YKERLMELQEAVRWTEMIRASRENPAMQEK 547
             D +    Q     R+    +   RN     K+  + L +A+R  E +   +E  AM E+
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL---KEQLAMVER 1682

Query: 548  KRSSIWQFFSRLFSSSSNTTKK----------PEPPVNLKYNAPTSHVTPSVKKRSSTLS 597
            + + +      L ++   T +               V L +   TS +  + KK  + +S
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN-TKKKLETDIS 1741

Query: 598  QLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQV 657
            Q+ G+     D L E      A   E+K ++     A + +E             K +Q 
Sbjct: 1742 QMQGEME---DILQE------ARNAEEKAKKAITDAAMMAEE------------LKKEQD 1780

Query: 658  TNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVA 717
            T+   E   KN+   V       KD  ++L  A  + L GGK +    +       +++ 
Sbjct: 1781 TSAHLERMKKNMEQTV-------KDLQLRLDEAEQLALKGGKKQ----IQKLEARVRELE 1829

Query: 718  GLDTEGSKQRSASQSSLDKLDQELKE----QQKELKNQEELSSLV 758
            G      K+ + +   L K ++ +KE     +++ KN   L  LV
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV 1874


>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
            sapiens]
          Length = 1941

 Score = 65.9 bits (159), Expect = 3e-10
 Identities = 149/728 (20%), Positives = 287/728 (39%), Gaps = 99/728 (13%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFI----EFEDSQEQEKK------DLQT 119
            E + E+  ++++ +++  +  + +A RK  EEK +    E  D Q Q +       D + 
Sbjct: 850  ETEKEMATMKEEFQKIKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQAEAEGLADAEE 909

Query: 120  RVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKL 179
            R + L     QLE K K   ++    EE  AEL  +   L    +E+  + ++ LE T  
Sbjct: 910  RCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKD-IDDLELTLA 968

Query: 180  HQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQ 239
                     E+   +   +   +   I  L      L    Q+  +   +E+ K   L++
Sbjct: 969  KVEKEKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTK 1028

Query: 240  PRSHTSLKVSNSPEPQKAVEQEDEL-SDVSQGGSKATTPASTANSDVATIPTDTPLKEE- 297
             +     +V    + + ++EQE +L  D+ +   K       A   +  I  +    +E 
Sbjct: 1029 AKIKLEQQVD---DLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEK 1085

Query: 298  -NEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKD 356
              +   ++++  +K E  + + +Q+ ++ + +     E EE+ E +    +  E     D
Sbjct: 1086 LKKKEFEISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAE-KQRSD 1144

Query: 357  LSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVD----EGADLLGMGREVEN 412
            LS                  R  E + E L  AG      ++      A+   M R++E 
Sbjct: 1145 LS------------------RELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEE 1186

Query: 413  LILEN---------------TQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQ 457
              L++                +L E  + L  VK  L  +  E+  E D L   +E V +
Sbjct: 1187 ATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSK 1246

Query: 458  AKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRV--EMARVLMER 515
            AK  LE+  R LE++L + +++ E+ ++   D       TAQR R      E +R L E+
Sbjct: 1247 AKGNLEKMCRTLEDQLSELKSKEEEQQRLIND------LTAQRGRLQTESGEFSRQLDEK 1300

Query: 516  NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVN 575
                 +L   ++A  +T+ I   +     + K ++++    +    SS +          
Sbjct: 1301 EALVSQLSRGKQA--FTQQIEELKRQLEEEIKAKNAL----AHALQSSRH---------- 1344

Query: 576  LKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSE---ETEASLASRREQKREQYRQV 632
                     +    ++   + ++L    SKA   +++   + E     R E+  E  +++
Sbjct: 1345 -----DCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAKKKL 1399

Query: 633  KAHVQKEDGRVQAFGWSLP--QKYKQVTNGQGENKMKNLP-VPVYLRPLDEKDTSMKLWC 689
               +Q  +  V+A        +K KQ    + E+ M ++         LD+K  +     
Sbjct: 1400 AQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQRNFDKIL 1459

Query: 690  AVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELK 749
            A        K  +  + + AS   K+   L TE  K ++A + SLD+L + LK + K L 
Sbjct: 1460 AEWKQ----KCEETHAELEAS--QKEARSLGTELFKIKNAYEESLDQL-ETLKRENKNL- 1511

Query: 750  NQEELSSL 757
             Q+E+S L
Sbjct: 1512 -QQEISDL 1518



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 101/476 (21%), Positives = 193/476 (40%), Gaps = 95/476 (19%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKF 103
            EE  K+L   + A  E++++V A+    +   + L+++ E L+   ER  A     ++K 
Sbjct: 1393 EEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALDKKQ 1452

Query: 104  IEFED---SQEQEKKDLQTRVESLESQTRQLE---LKAKN-YADQISRLEEREAELKKEY 156
              F+      +Q+ ++    +E+ + + R L     K KN Y + + +LE     LK+E 
Sbjct: 1453 RNFDKILAEWKQKCEETHAELEASQKEARSLGTELFKIKNAYEESLDQLET----LKREN 1508

Query: 157  NALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLL 216
              L Q  +++     E  +R  +H+L            +I+K+  +      L A     
Sbjct: 1509 KNLQQEISDLTEQIAEGGKR--IHELE-----------KIKKQ--VEQEKCELQAA---- 1549

Query: 217  TPDAQKGGETPGSEQWKFQ-ELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKAT 275
              +A+   E    +  + Q EL+Q +S    K++         E+++E+  + +   +  
Sbjct: 1550 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA---------EKDEEIDQLKRNHIRIV 1600

Query: 276  -TPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS-KHIEVQVAQETRNVSTGSA 333
             +  ST ++++ +      LK++ EG +      N+ EI   H     A+  RN      
Sbjct: 1601 ESMQSTLDAEIRSRNDAIRLKKKMEGDL------NEMEIQLNHANRMAAEALRNYRN--- 1651

Query: 334  ENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSA---- 389
                    Q I++ T ++ +D  L   +        +E +A     E   EEL +     
Sbjct: 1652 -------TQGILKDT-QIHLDDALRSQEDLKEQLAMVERRANLLQAE--IEELRATLEQT 1701

Query: 390  -GSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDV- 447
              S  I +     +LL     V+ L  +NT L+ TK  L                E D+ 
Sbjct: 1702 ERSRKIAE----QELLDASERVQLLHTQNTSLINTKKKL----------------ETDIS 1741

Query: 448  -LQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKR 502
             +QGE+E + Q       + R  EE+ +KA  +A    ++ K + D+     + K+
Sbjct: 1742 QMQGEMEDILQ-------EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1790



 Score = 39.3 bits (90), Expect = 0.025
 Identities = 94/452 (20%), Positives = 185/452 (40%), Gaps = 63/452 (13%)

Query: 69   QEHQVELELLRDDNEQL------ITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVE 122
            +E   +LE L+ +N+ L      +T+   E   R H  EK    +   EQEK +LQ  +E
Sbjct: 1495 EESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI---KKQVEQEKCELQAALE 1551

Query: 123  SLESQTRQLE---LKAKNYADQI-SRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTK 178
              E+     E   L+ +   +Q+ S ++ + AE  +E + L + H  ++ +    L+  +
Sbjct: 1552 EAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLD-AE 1610

Query: 179  LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKG---------GETPGS 229
            +   + + +L+      +  E  I L      A + L      +G          +   S
Sbjct: 1611 IRSRNDAIRLKKKMEGDLN-EMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRS 1669

Query: 230  EQWKFQELSQPRSHTSLKVSNSPEPQKAVEQ--------EDELSDVSQGGSKATTPASTA 281
            ++   ++L+      +L  +   E +  +EQ        E EL D S+      T  ++ 
Sbjct: 1670 QEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSL 1729

Query: 282  NSDVATIPTD-TPLKEENEGFVKVTDAPNKSEISKHI---EVQVAQETRNVSTGSA--EN 335
             +    + TD + ++ E E  ++  +A N  E +K        +A+E +     SA  E 
Sbjct: 1730 INTKKKLETDISQMQGEMEDILQ--EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLER 1787

Query: 336  EEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIG 395
             +K+  Q + +    LD  + L+  KG     + +E +  +   E   E+  +A      
Sbjct: 1788 MKKNMEQTVKDLQLRLDEAEQLA-LKGGKKQIQKLEARVRELEGEVESEQKRNA------ 1840

Query: 396  DVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAV 455
              +    L    R V+ L  +  +  + KN L +   DL+          D LQ ++++ 
Sbjct: 1841 --EAVKGLRKHERRVKELTYQTEE--DRKNILRL--QDLV----------DKLQAKVKSY 1884

Query: 456  KQAKLKLEEKNRELEEELRKARAEAEDARQKA 487
            K+   + EE++     + RK + E E+A ++A
Sbjct: 1885 KRQAEEAEEQSNTNLAKFRKLQHELEEAEERA 1916



 Score = 37.4 bits (85), Expect = 0.096
 Identities = 161/825 (19%), Positives = 297/825 (36%), Gaps = 167/825 (20%)

Query: 58   LENLDSVFAQDQEHQVELEL----LRDDNEQLITQYEREKALRKHAEEKFIEFE------ 107
            + NL S    +Q   ++L+     L+   E+L  + E E+A R  AE++  +        
Sbjct: 1093 ISNLQSKIEDEQALGIQLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEI 1152

Query: 108  ---------------DSQEQEKKDLQTRVESLESQTRQLELKA----KNYADQISRLEER 148
                           +  ++ + + Q     LE  T Q E  A    K +AD ++ L E+
Sbjct: 1153 SERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQ 1212

Query: 149  EAELKKEYNALHQRHTEM------IHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPI 202
               L++    L +  +EM      + + +E + + K +       LE        KE   
Sbjct: 1213 IDNLQRVKQKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQ 1272

Query: 203  SLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQE- 261
               I  L A  G L  ++ +       ++    +LS+ +   + ++    E ++ +E+E 
Sbjct: 1273 QRLINDLTAQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIE---ELKRQLEEEI 1329

Query: 262  ---------------------DELSDVSQGGSKATTPASTANSDVA----TIPTDTPLKE 296
                                 ++  +  +  ++     S AN++VA       TD   + 
Sbjct: 1330 KAKNALAHALQSSRHDCDLLREQYEEEQESKAELQRALSKANTEVAQWRTKYETDAIQRT 1389

Query: 297  ENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIEST-------- 348
            E     K   A       +H+E   A+      T      E  ++   +E T        
Sbjct: 1390 EELEEAKKKLAQRLQAAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERTNAACAALD 1449

Query: 349  -PELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMG 407
              + + DK L+ +K     T   E +A  +   SL  EL    +     +D+   L  + 
Sbjct: 1450 KKQRNFDKILAEWKQKCEETHA-ELEASQKEARSLGTELFKIKNAYEESLDQ---LETLK 1505

Query: 408  REVENLILENTQLLE--TKNALNIVKNDLIAK-VDELTCEKDVLQGELEA---------- 454
            RE +NL  E + L E   +    I + + I K V++  CE      E EA          
Sbjct: 1506 RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQVEQEKCELQAALEEAEASLEHEEGKIL 1565

Query: 455  -----VKQAKLKLEEKNRELEEEL-------------------RKARAEAEDARQKAKDD 490
                 + Q K +++ K  E +EE+                    + R+  +  R K K +
Sbjct: 1566 RIQLELNQVKSEVDRKIAEKDEEIDQLKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKME 1625

Query: 491  DDSDIPTAQRKRFTRVEMARVLMERNQ---YKERLMELQEAVRWTEMIRASRENPAMQEK 547
             D +    Q     R+    +   RN     K+  + L +A+R  E +   +E  AM E+
Sbjct: 1626 GDLNEMEIQLNHANRMAAEALRNYRNTQGILKDTQIHLDDALRSQEDL---KEQLAMVER 1682

Query: 548  KRSSIWQFFSRLFSSSSNTTKK----------PEPPVNLKYNAPTSHVTPSVKKRSSTLS 597
            + + +      L ++   T +               V L +   TS +  + KK  + +S
Sbjct: 1683 RANLLQAEIEELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLIN-TKKKLETDIS 1741

Query: 598  QLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQV 657
            Q+ G+     D L E      A   E+K ++     A + +E             K +Q 
Sbjct: 1742 QMQGEME---DILQE------ARNAEEKAKKAITDAAMMAEE------------LKKEQD 1780

Query: 658  TNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVA 717
            T+   E   KN+   V       KD  ++L  A  + L GGK +    +       +++ 
Sbjct: 1781 TSAHLERMKKNMEQTV-------KDLQLRLDEAEQLALKGGKKQ----IQKLEARVRELE 1829

Query: 718  GLDTEGSKQRSASQSSLDKLDQELKE----QQKELKNQEELSSLV 758
            G      K+ + +   L K ++ +KE     +++ KN   L  LV
Sbjct: 1830 GEVESEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLV 1874


>gi|156104908 myosin heavy chain 6 [Homo sapiens]
          Length = 1939

 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 150/731 (20%), Positives = 284/731 (38%), Gaps = 105/731 (14%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTR 129
            E + E+  ++++  ++    E+ +A RK  EEK +    S  QEK DLQ +V++ +    
Sbjct: 846  ETEKEMATMKEEFGRIKETLEKSEARRKELEEKMV----SLLQEKNDLQLQVQAEQDNLN 901

Query: 130  --------------QLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
                          QLE K K   +++   EE  AEL  +   L    +E+  + ++ LE
Sbjct: 902  DAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKD-IDDLE 960

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
             T           E+   +   +   +   I  L      L    Q+  +    E+ K  
Sbjct: 961  LTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQVEEDKVN 1020

Query: 236  ELSQPRSHTSLKVSN---SPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDT 292
             LS+ +     +V +   S E +K V  + E +     G    T  S  + +   +  + 
Sbjct: 1021 SLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKLQLEE 1080

Query: 293  PLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELD 352
             LK++      +    +K E  + + +Q+ ++ +       E EE+ E +    +  E  
Sbjct: 1081 KLKKKE---FDINQQNSKIEDEQVLALQLQKKLKENQARIEELEEELEAERTARAKVE-K 1136

Query: 353  MDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG----ADLLGMGR 408
            +  DLS                  R  E + E L  AG      ++      A+   M R
Sbjct: 1137 LRSDLS------------------RELEEISERLEEAGGATSVQIEMNKKREAEFQKMRR 1178

Query: 409  EVENLILEN---------------TQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELE 453
            ++E   L++                +L E  + L  VK  L  +  E   E D +   +E
Sbjct: 1179 DLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNME 1238

Query: 454  AVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRF--TRVEMARV 511
             + +AK  LE+ +R LE++  + R + E+A++   D       T QR +      E+AR 
Sbjct: 1239 QIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDF------TTQRAKLQTENGELARQ 1292

Query: 512  LMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPE 571
            L E+     +L   +  + +T+ +   +     + K ++++        + +  + +   
Sbjct: 1293 LEEKEALISQL--TRGKLSYTQQMEDLKRQLEEEGKAKNAL--------AHALQSARHDC 1342

Query: 572  PPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQ 631
              +  +Y   T       +  S   S++   ++K       ET+A    R E+  E  ++
Sbjct: 1343 DLLREQYEEETEAKAELQRVLSKANSEVAQWRTK------YETDA--IQRTEELEEAKKK 1394

Query: 632  VKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPV-----YLRPLDEKDTSMK 686
            +   +Q  +  V+A         K  T  + +N++++L V V         LD+K  +  
Sbjct: 1395 LAQRLQDAEEAVEAVNAKCSSLEK--TKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFD 1452

Query: 687  LWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQK 746
               A        K  +  S + +S   K+   L TE  K ++A + SL+ L +  K + K
Sbjct: 1453 KILAEWKQ----KYEESQSELESS--QKEARSLSTELFKLKNAYEESLEHL-ETFKRENK 1505

Query: 747  ELKNQEELSSL 757
             L  QEE+S L
Sbjct: 1506 NL--QEEISDL 1514



 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 162/778 (20%), Positives = 287/778 (36%), Gaps = 160/778 (20%)

Query: 68   DQEHQVELELLRDDNEQLITQYEREKAL--RKHAE---------EKFIEFEDSQEQEKKD 116
            +++ + E + +R D E+   Q+E   A   +KHA+         +     +   E+EK +
Sbjct: 1166 NKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSE 1225

Query: 117  LQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLER 176
             +  ++ + S   Q+ +KAK   +++SR  E +A    EY    +     ++++    +R
Sbjct: 1226 FKLELDDVTSNMEQI-IKAKANLEKVSRTLEDQAN---EYRVKLEEAQRSLNDFTT--QR 1279

Query: 177  TKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTP---DAQKGGETPGSEQWK 233
             KL   +G       A     KE  IS     L  G    T    D ++  E  G  +  
Sbjct: 1280 AKLQTENGE-----LARQLEEKEALIS----QLTRGKLSYTQQMEDLKRQLEEEGKAKNA 1330

Query: 234  FQELSQPRSHTS--LKVSNSPEPQKAVEQEDELS----DVSQGGSKATTPA--STANSDV 285
                 Q   H    L+     E +   E +  LS    +V+Q  +K  T A   T   + 
Sbjct: 1331 LAHALQSARHDCDLLREQYEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEELEE 1390

Query: 286  ATIPTDTPLKEENEGFVKVTDAPNKSEISKHI------EVQVAQETRNVSTGSAENEEKS 339
            A       L++  E    V    +  E +KH       ++ V  E  N +  + + ++++
Sbjct: 1391 AKKKLAQRLQDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN 1450

Query: 340  -------------EVQAIIESTPELDMDKDLSGYKGSSTPTKGIEN-KAFDRNTESLFEE 385
                         E Q+ +ES+ +         +K  +   + +E+ + F R  ++L EE
Sbjct: 1451 FDKILAEWKQKYEESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQEE 1510

Query: 386  LSSAGSGLIGDVDEGADLLGMGR---EVENLILENT-------------QLLETKNALNI 429
            +S     L G+  +    L   R   EVE L L++              ++L  +   N 
Sbjct: 1511 ISDLTEQL-GEGGKNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQ 1569

Query: 430  VKNDLIAKVDELTCEK-----------DVLQGELEA-------VKQAKLKLEEKNRELEE 471
            +K ++  K+ E   E            D LQ  L+A       V + K K+E    E+E 
Sbjct: 1570 IKAEIERKLAEKDEEMEQAKRNHQRVVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEI 1629

Query: 472  ELRKARAEAEDARQKAKD------DDDSDIPTAQRKRFTRVEMARVLMERNQ-YKERLME 524
            +L  A   A +A+++ K       D    +  A R      E   ++  RN   +  L E
Sbjct: 1630 QLSHANRMAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEE 1689

Query: 525  LQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSH 584
            L+  V  TE  R   E   ++  +R                        V L ++  TS 
Sbjct: 1690 LRAVVEQTERSRKLAEQELIETSER------------------------VQLLHSQNTSL 1725

Query: 585  VTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 644
            +    KK  S L+QL           SE  EA    R  +++ +     A +  E+    
Sbjct: 1726 INQK-KKMESDLTQLQ----------SEVEEAVQECRNAEEKAKKAITDAAMMAEE---- 1770

Query: 645  AFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGG 704
                    K +Q T+   E   KN+   +       KD   +L  A  + L GGK +   
Sbjct: 1771 -------LKKEQDTSAHLERMKKNMEQTI-------KDLQHRLDEAEQIALKGGKKQ--- 1813

Query: 705  SVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKE----QQKELKNQEELSSLV 758
             +       +++ G      K+ + S   + K ++ +KE     +++ KN   L  LV
Sbjct: 1814 -LQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQDLV 1870


>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
          Length = 1094

 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 122/639 (19%), Positives = 251/639 (39%), Gaps = 47/639 (7%)

Query: 78  LRDDNEQLITQYEREKALRKHAEEKFIE-FEDSQEQE--KKDLQTRVESLESQTRQLELK 134
           L DD  + +++  R  A  K A E+  E   ++Q+QE     ++ R++ LE + R     
Sbjct: 178 LGDDFNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTEREL 237

Query: 135 AKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHS 194
            +   DQ+  +  +  E  K+  A    H   I N +   E T+ +QL    +L     +
Sbjct: 238 VERRQDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTE-TEKNQLEQELELSRRLLN 296

Query: 195 RIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEP 254
           +    R   L        + L T   +  G+  G  Q +  ++S+ +S+   +       
Sbjct: 297 QSEGSRETLLHQV-----EELRTQLTKAEGDRKGL-QHQVSQISKQQSNYQDEQGEDWRF 350

Query: 255 QKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFV--KVTDAPNKSE 312
           ++ VE+E +  +      +     S   S++  +      K++ +  +  +V +   + E
Sbjct: 351 RRGVEREKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELE 410

Query: 313 ISKHIEVQVAQETRNVST--GSAENEEKSEVQAIIESTPEL-DMDKDLSGYKGSSTPTKG 369
             +  ++Q+    + +     + E E K     I E T    D  K    Y      ++ 
Sbjct: 411 NGEKQQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEA 470

Query: 370 IENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNI 429
           ++ +A  R  +   +   S     +        L      V+ L  +N Q+L+ K+ L  
Sbjct: 471 LKEEAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDEL-- 528

Query: 430 VKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKD 489
            K  L A + ++    + L+ EL  V   +   EE+    EE+LR  ++   D   + K+
Sbjct: 529 -KTQLYAALQQI----ENLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKN 583

Query: 490 DDD------------SDIPTAQR--KRFTRVEMARVLMERNQYKERLMELQEAVRWTEMI 535
             D            S I +  +  K     E+A +   + Q K +L+E+QE+++    I
Sbjct: 584 SLDTIHRLESELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAI 643

Query: 536 RASRENP-AMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPV-NLK-----YNAPTSHVTPS 588
           RA   N  A +E+ + ++ +  S L + + +  ++    +  LK     +      +T S
Sbjct: 644 RADLANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSS 703

Query: 589 VKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGW 648
           ++   +   Q   +  K F     E E  + + + +  E+    K H     G+++    
Sbjct: 704 LQSVKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKIH----RGQLEKLKS 759

Query: 649 SLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKL 687
              +  +++T  + ENK   L        L+E++  + +
Sbjct: 760 QCDRLTEELTQNENENKKLKLKYQCLKDQLEEREKHISI 798



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 62/283 (21%), Positives = 108/283 (38%), Gaps = 67/283 (23%)

Query: 76  ELLRDDNE---QLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLE 132
           ++L++ +E   QL    ++ + LRK   +   +    QE+E    + ++  ++S    LE
Sbjct: 520 QILKEKDELKTQLYAALQQIENLRKELNDVLTK-RALQEEELHSKEEKLRDIKSHQADLE 578

Query: 133 LKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTA 192
           L+ KN  D I RLE   +ELKK+     Q   E  H   E  E  K      +  LE   
Sbjct: 579 LEVKNSLDTIHRLE---SELKKQSKIQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEM-- 633

Query: 193 HSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSP 252
                                                 Q   ++LS  R+  + K++   
Sbjct: 634 --------------------------------------QESIKDLSAIRADLANKLAEEE 655

Query: 253 EPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEE-----------NEGF 301
             +KAV ++  LSD+       T  A + + + ATI T   L+ +           +   
Sbjct: 656 RAKKAVLKD--LSDL-------TAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQS 706

Query: 302 VKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAI 344
           VK     N  E+ KH + + ++   ++ T  AE+ E+  +  I
Sbjct: 707 VKTKHEQNIQELMKHFKKEKSEAENHIRTLKAESLEEKNMAKI 749



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 87/454 (19%), Positives = 187/454 (41%), Gaps = 58/454 (12%)

Query: 62  DSVFAQDQEHQVELELLRDDNEQL---ITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQ 118
           +++  Q +E + +L     D + L   ++Q  ++++  +  + +   F    E+EK+DL+
Sbjct: 303 ETLLHQVEELRTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVEREKQDLE 362

Query: 119 TRVESLESQTRQLELKAKNYADQISRLEE--REAELKKEYNALHQRHTEMIHNYMEHLER 176
            ++  L  Q         N++   S LEE  R  E K +  A      E +   +E+ E+
Sbjct: 363 KQMSDLRVQL--------NFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEK 414

Query: 177 TKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKG-GETPGSEQWKFQ 235
            +L  L    ++++   +   + +   L I  L       T  A++   E   SE  K +
Sbjct: 415 QQLQMLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALK-E 473

Query: 236 ELSQPRSHTSLKVSNS--------PEPQKAVEQEDELSDVSQGGSK-------------- 273
           E  + R    LK   S         + ++A+E++ E  D   G +               
Sbjct: 474 EAEKRREDLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLY 533

Query: 274 -ATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGS 332
            A         ++  + T   L+EE E   K     +       +E++V      +    
Sbjct: 534 AALQQIENLRKELNDVLTKRALQEE-ELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLE 592

Query: 333 AENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSG 392
           +E +++S++Q+ ++   +  ++++++  K S       ++KA     +   ++LS+  + 
Sbjct: 593 SELKKQSKIQSQMK-VEKAHLEEEIAELKKSQA-----QDKAKLLEMQESIKDLSAIRAD 646

Query: 393 LIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGEL 452
           L       A+ L      +  +L++   L  +      +   I  + +L  E+DV Q EL
Sbjct: 647 L-------ANKLAEEERAKKAVLKDLSDLTAQAKSRDEETATI--ITQLKLERDVHQREL 697

Query: 453 E----AVKQAKLKLEEKNRELEEELRKARAEAED 482
           +    +++  K K E+  +EL +  +K ++EAE+
Sbjct: 698 KDLTSSLQSVKTKHEQNIQELMKHFKKEKSEAEN 731


>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
            sapiens]
          Length = 1938

 Score = 63.9 bits (154), Expect = 1e-09
 Identities = 147/737 (19%), Positives = 287/737 (38%), Gaps = 117/737 (15%)

Query: 70   EHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVES-----L 124
            E + E+  +++D E+   +  R +A RK  EEK +    S  QEK DLQ +V+S     +
Sbjct: 848  EAEKEMATMKEDFERTKEELARSEARRKELEEKMV----SLLQEKNDLQLQVQSETENLM 903

Query: 125  ESQTR---------QLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLE 175
            +++ R          LE K K   +++   EE  +EL  +   L  + + +  + ++ LE
Sbjct: 904  DAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKKRNLEDKCSSLKRD-IDDLE 962

Query: 176  RTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
             T         ++E   H+   K + +S  +  L      LT + +K  +    +     
Sbjct: 963  LT-------LTKVEKEKHATENKVKNLSEEMTALEENISKLTKE-KKSLQEAHQQTLDDL 1014

Query: 236  ELSQPRSHTSLKVSNSPEPQK-----AVEQEDEL-SDVSQGGSKATTPASTANSDVATIP 289
            ++ + + +  +K++   E Q      ++EQE +L +D+ +   K       +   +  + 
Sbjct: 1015 QVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERAKRKLEGDLKMSQESIMDLE 1074

Query: 290  TDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTP 349
             D   K++ E  +K      + E+S   ++Q   +   V +   + + K E+QA IE   
Sbjct: 1075 ND---KQQIEEKLK----KKEFELS---QLQAKIDDEQVHSLQFQKKIK-ELQARIEELE 1123

Query: 350  ELDMDKDLSGYKGSSTPTKGIENKAFD--RNTESLFEELSSAGSGLIGDVD----EGADL 403
            E          +   T    IE +  D  R  E + E L  A       ++      A+ 
Sbjct: 1124 E--------EIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEF 1175

Query: 404  LGMGREVENLILEN---------------TQLLETKNALNIVKNDLIAKVDELTCEKDVL 448
              M R++E   L++                +L E  + L  VK  L  +  EL  E D +
Sbjct: 1176 QKMRRDLEEATLQHEATAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDM 1235

Query: 449  QGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEM 508
               +EA+ ++K  +E   R +E++  + +A+ E   Q   D                ++ 
Sbjct: 1236 ASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQTQLIHD--------------LNMQK 1281

Query: 509  ARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTK 568
            AR+  +  +   R+ E +  +             +   K + ++ Q    L       TK
Sbjct: 1282 ARLQTQNGELSHRVEEKESLI-------------SQLTKSKQALTQQLEELKRQMEEETK 1328

Query: 569  KPEPPVNLKYNA--PTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSE---ETEASLASRRE 623
                  +   ++      +    ++     ++L    SKA   +++   + E     R E
Sbjct: 1329 AKNAMAHALQSSRHDCDLLREQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTE 1388

Query: 624  QKREQYRQVKAHVQKEDGRVQAFGWSLP--QKYKQVTNGQGENKMKNLP-VPVYLRPLDE 680
            +  E  +++   +Q+ +   +         +K KQ   G+ E+ M++L         LD+
Sbjct: 1389 ELEEAKKKLAQRLQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDK 1448

Query: 681  KDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQE 740
            K  +          L+  K +   S        K+   L TE  K R+A +  +D+L + 
Sbjct: 1449 KQRNF------DKVLAEWKQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQL-ET 1501

Query: 741  LKEQQKELKNQEELSSL 757
            L+ + K L  QEE+S L
Sbjct: 1502 LRRENKNL--QEEISDL 1516



 Score = 40.4 bits (93), Expect = 0.011
 Identities = 96/472 (20%), Positives = 188/472 (39%), Gaps = 82/472 (17%)

Query: 45   EVVKELMPLVVAVLENLDSVFAQDQEHQ------VELELLRDDNEQLITQYEREKALRKH 98
            ++ KE   L  A  + LD +  ++ +         +LE   DD E  + Q ++ +A  + 
Sbjct: 995  KLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLER 1054

Query: 99   AEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNA 158
            A+ K        E + K  Q  +  LE+  +Q+E K K    ++S+L   +A++  E   
Sbjct: 1055 AKRKL-------EGDLKMSQESIMDLENDKQQIEEKLKKKEFELSQL---QAKIDDE--- 1101

Query: 159  LHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTP 218
              Q H+      ++ L+  ++ +L    + E T  ++I K+R                  
Sbjct: 1102 --QVHSLQFQKKIKELQ-ARIEELEEEIEAEHTLRAKIEKQR-----------------S 1141

Query: 219  DAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDE--LSDVSQGGSKATT 276
            D  +          + +E+S+     S   S   E  K  E E +    D+ +   +   
Sbjct: 1142 DLAR----------ELEEISERLEEASGATSAQIEMNKKREAEFQKMRRDLEEATLQHEA 1191

Query: 277  PASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQ-ETRNVSTGSAE- 334
             A+T     A    +   + +N   VK      KSE+   I+   +  E  + S  + E 
Sbjct: 1192 TAATLRKKQADSVAELGEQIDNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIER 1251

Query: 335  -----NEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSA 389
                  ++ SE++A  E   +L  D ++   + +   T+  E        ESL  +L+ +
Sbjct: 1252 TCRTVEDQFSEIKAKDEQQTQLIHDLNM---QKARLQTQNGELSHRVEEKESLISQLTKS 1308

Query: 390  GSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQ 449
               L   ++E      + R++E          ETK      KN +   +     + D+L+
Sbjct: 1309 KQALTQQLEE------LKRQMEE---------ETK-----AKNAMAHALQSSRHDCDLLR 1348

Query: 450  GELEAVKQAKLKLEEKNRELEEELRKARAEAE-DARQKAKDDDDSDIPTAQR 500
             + E  ++AK +L+    +   E+ + R + E DA Q+ ++ +++    AQR
Sbjct: 1349 EQYEEEQEAKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQR 1400



 Score = 38.9 bits (89), Expect = 0.033
 Identities = 79/453 (17%), Positives = 172/453 (37%), Gaps = 58/453 (12%)

Query: 48   KELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFE 107
            K L   +  + E +       QE +   +L+  +   L    E  +   +H E K +  +
Sbjct: 1507 KNLQEEISDLTEQIAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQ 1566

Query: 108  DSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAE-------LKKEYNA-L 159
                Q K +L  +V   + +  QL+  ++  A+ +  + + E         LKK+    L
Sbjct: 1567 LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKKMEGDL 1626

Query: 160  HQRHTEMIHNYMEHLERTKLHQLSGSDQL-ESTAH--SRIRKERPISLGIFPLPAGDGLL 216
            ++   ++ H+  +  E T+ H  +   QL +S  H    +R    +   +  +   +GLL
Sbjct: 1627 NEMEIQLGHSNRQMAE-TQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLL 1685

Query: 217  TPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATT 276
              + ++             +++  ++  + ++S     Q+ ++  D +  +    +    
Sbjct: 1686 LEELEE------------MKVALEQTERTRRLSE----QELLDASDRVQLLHSQNTSLIN 1729

Query: 277  PASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSA--E 334
                  +D+A         E      +  +A  K++ +      +A+E +     SA  E
Sbjct: 1730 TKKKLEADIAQCQA-----EVENSIQESRNAEEKAKKAITDAAMMAEELKKEQDTSAHLE 1784

Query: 335  NEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLI 394
              +K+  Q + +    LD  + L+  KG     + +EN+  +   E   E+         
Sbjct: 1785 RMKKNLEQTVKDLQHRLDEAEQLA-LKGGKKQIQKLENRVRELENELDVEQ--------- 1834

Query: 395  GDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEA 454
                 GA+ L    + E  + E T   E  +   +   DL+          D LQ ++++
Sbjct: 1835 ---KRGAEALKGAHKYERKVKEMTYQAEEDHKNILRLQDLV----------DKLQAKVKS 1881

Query: 455  VKQAKLKLEEKNRELEEELRKARAEAEDARQKA 487
             K+   + EE+        R+ + E E+A ++A
Sbjct: 1882 YKRQAEEAEEQANTQLSRCRRVQHELEEAAERA 1914



 Score = 36.6 bits (83), Expect = 0.16
 Identities = 75/441 (17%), Positives = 166/441 (37%), Gaps = 48/441 (10%)

Query: 65   FAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL 124
            + ++QE + EL+         + Q+      R   E   I+  +  E+ KK L  R++  
Sbjct: 1351 YEEEQEAKAELQRALSKANSEVAQW------RTKYETDAIQRTEELEEAKKKLAQRLQEA 1404

Query: 125  ESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM--IHNYMEHLERTKLHQL 182
            E  T     K  +      RL+    +L ++   L + HT    +     + ++      
Sbjct: 1405 EENTETANSKCASLEKTKQRLQGEVEDLMRD---LERSHTACATLDKKQRNFDKVLAEWK 1461

Query: 183  SGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRS 242
               D+ ++   +  ++ R +S  +F +      +    +       + Q +  +L++  +
Sbjct: 1462 QKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLRRENKNLQEEISDLTEQIA 1521

Query: 243  HTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFV 302
             T   +  + + +K VEQE                   ++  VA    +  L+ E    +
Sbjct: 1522 ETGKNLQEAEKTKKLVEQEK------------------SDLQVALEEVEGSLEHEESKIL 1563

Query: 303  KVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSE-VQAIIES-----TPELDMDKD 356
            +V      S++   ++ +V ++   +      ++  +E +Q+++++        L + K 
Sbjct: 1564 RVQ--LELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKKK 1621

Query: 357  LSGYKGSSTPTKGIENKAF---DRNTESLFEELSSAGSGLIGDVDEGADL---LGMGREV 410
            + G         G  N+      ++  ++  +L  +   L   +    DL   L +    
Sbjct: 1622 MEGDLNEMEIQLGHSNRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERR 1681

Query: 411  ENLILENTQLLETKNALNIVKNDLIAKVDELTCEKD---VLQGELEAVKQAKLKLEEKNR 467
              L+LE  +L E K AL   +        EL    D   +L  +  ++   K KLE    
Sbjct: 1682 NGLLLE--ELEEMKVALEQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIA 1739

Query: 468  ELEEELRKARAEAEDARQKAK 488
            + + E+  +  E+ +A +KAK
Sbjct: 1740 QCQAEVENSIQESRNAEEKAK 1760


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
            [Homo sapiens]
          Length = 1354

 Score = 63.5 bits (153), Expect = 1e-09
 Identities = 132/623 (21%), Positives = 246/623 (39%), Gaps = 88/623 (14%)

Query: 79   RDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNY 138
            R + E  ++Q E+EK L +H   ++    + + +++++++  V +L+ Q   L+  ++N 
Sbjct: 474  RRNLESTVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNS 533

Query: 139  A---DQISRLEEREAE----LKKEYNA---LHQRHTEMIHNYM-------EHLERTKLHQ 181
                +++S+L+++  E    L+ E +    L + HTEM  +         E  ER ++ +
Sbjct: 534  QLANEKLSQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILE 593

Query: 182  LSGSD------QLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQ 235
             S S       QL++   +  R     S  I  L A    L  + +         + + +
Sbjct: 594  NSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERK 653

Query: 236  ELSQPRSHTSLKVSNSP--------EPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT 287
            E     +H+  + +N            Q+ +EQE     V++        +      VA 
Sbjct: 654  EAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAM 713

Query: 288  IPTDTPLKEENEGFVKVTDAPNKSEIS---KHIEVQVAQETRNVSTGSAENEEKS----E 340
               +  LKEE E   K  +   + E       ++++ +Q+     TG+ E  E       
Sbjct: 714  CEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLT 773

Query: 341  VQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFE----------ELSSAG 390
            +Q   ES   L +  +L      +   KG+E K   +   +L E          +L+   
Sbjct: 774  LQLEQESNKRLLLQNELKTQAFEADNLKGLE-KQMKQEINTLLEAKRLLEFELAQLTKQY 832

Query: 391  SGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQG 450
             G  G + E  D L   +    L    TQ+ E K  +     + + K+ EL  EK+ L  
Sbjct: 833  RGNEGQMRELQDQLEAEQYFSTLY--KTQVKELKEEIEEKNRENLKKIQELQNEKETLAT 890

Query: 451  EL-------EAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRF 503
            +L       E+ + A+  LEE+  EL +E +KA   A   RQ+  D D +          
Sbjct: 891  QLDLAETKAESEQLARGLLEEQYFELTQESKKA---ASRNRQEITDKDHT---------V 938

Query: 504  TRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSS 563
            +R+E A  ++ ++                E++R  REN  + EK + +  ++        
Sbjct: 939  SRLEEANSMLTKD---------------IEILR--RENEELTEKMKKAEEEYKLEKEEEI 981

Query: 564  SNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETE-ASLASRR 622
            SN     E  +N +    T  V    +  +    ++   K+   D   +E E   L    
Sbjct: 982  SNLKAAFEKNINTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLEL 1041

Query: 623  EQKREQYRQVKAHVQKEDGRVQA 645
             Q+RE++ Q+    QKE   +QA
Sbjct: 1042 NQEREKFNQMVVKHQKELNDMQA 1064



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 111/531 (20%), Positives = 201/531 (37%), Gaps = 77/531 (14%)

Query: 34   EFERLIGRYDEEVVKELMPLVVAVLE-------NLDSVFAQDQEHQVELELLRDDNEQL- 85
            E ER    +D E++ +L   + ++ E       NL+ V  + +E Q  L     +   L 
Sbjct: 611  EAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLE 670

Query: 86   ITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRL 145
            I    + K+L++  E++  E + ++ +     Q+  E+      ++E K K   +   + 
Sbjct: 671  IDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKA 730

Query: 146  EEREAELKKEYNALHQRHTEMIHNYMEHL----ERTKLHQLSGSDQLESTAHSRIRKERP 201
            E R  +++K+ + L     +     +EHL    ER +    + + QLE  ++ R+  +  
Sbjct: 731  ENRVVQIEKQCSMLDV-DLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQNE 789

Query: 202  ISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQE 261
            +    F      GL     Q+      +++    EL+Q             E Q  +E E
Sbjct: 790  LKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAE 849

Query: 262  DELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQV 321
               S + +   K                    LKEE E         N+  + K  E+Q 
Sbjct: 850  QYFSTLYKTQVKE-------------------LKEEIE-------EKNRENLKKIQELQN 883

Query: 322  AQETRNVSTGSAENEEKSEVQA-------IIESTPE------------LDMDKDLSGYK- 361
             +ET       AE + +SE  A         E T E             D D  +S  + 
Sbjct: 884  EKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDKDHTVSRLEE 943

Query: 362  GSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLL 421
             +S  TK IE     R  E L E++  A         E    L    E+ NL     + +
Sbjct: 944  ANSMLTKDIE--ILRRENEELTEKMKKA---------EEEYKLEKEEEISNLKAAFEKNI 992

Query: 422  ETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAE 481
             T+  L   K   + K+ E+   KD      +A  Q   K E++NR+L+ EL + R +  
Sbjct: 993  NTERTL---KTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFN 1049

Query: 482  D---ARQKAKDDDDSD-IPTAQRKRFTRVEMARVLMERNQYKERLMELQEA 528
                  QK  +D  +  +     +   ++++A    +  Q + +L++L ++
Sbjct: 1050 QMVVKHQKELNDMQAQLVEECAHRNELQMQLASKESDIEQLRAKLLDLSDS 1100


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 115/625 (18%), Positives = 231/625 (36%), Gaps = 85/625 (13%)

Query: 67  QDQEHQVELELLRDDNEQLITQYER-EKALRKHAEEKFIE-FEDSQEQEKKDLQTRVESL 124
           Q++E + + E  R+  E+   Q ER E+ LR+  EE+  +     QE+E+++ Q R E  
Sbjct: 310 QEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQ- 368

Query: 125 ESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSG 184
           E + R+ +L+ +    +  +L  RE +L++E     ++            +  +  QL  
Sbjct: 369 EEERREQQLRREQQLRREQQLR-REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 427

Query: 185 SDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHT 244
             + E       ++ R   L        D L   +  +  E    +Q   ++  + R   
Sbjct: 428 EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487

Query: 245 SLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKV 304
            LK+      ++   +E +L    +   +                    LK + E     
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQR------------------LKRQEE----- 524

Query: 305 TDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSS 364
                        E ++ Q  R+      E EE+ E     E    L+ ++         
Sbjct: 525 -------------EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR-------- 563

Query: 365 TPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENT--QLLE 422
              + ++ +  +R  + L  E       L  + +E  +      EVE L  E    Q L+
Sbjct: 564 --EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK 621

Query: 423 TKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAE--- 479
            +      +  L+   ++    +  L+ E +  ++ +LK EE+   LE+ L++   E   
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERR 681

Query: 480 ----AEDARQKAKDDDDSDIP-----------TAQRKRFTRVEMARVLMERNQYKERLME 524
               AE+ +++A++   S IP             Q K ++R         R + +E+   
Sbjct: 682 EQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR 741

Query: 525 LQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAP--- 581
            +  ++W E  RA R+    +E++R   WQ+ +   S          PP+  +       
Sbjct: 742 RESELQWQEEERAHRQQQE-EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800

Query: 582 ------TSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAH 635
                      P  +++     Q   ++ K   FL EE +     R +Q +E+   ++  
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQ-RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859

Query: 636 VQK----EDGRVQAFGWSLPQKYKQ 656
            ++    E  R Q + W L ++ K+
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKR 884



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 118/622 (18%), Positives = 236/622 (37%), Gaps = 83/622 (13%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEK---FIEFEDSQEQEKK 115
            E  D +  +++E + +  L R+  E+L  + +RE+  R   EE+    ++ E+ +E+ ++
Sbjct: 573  ERRDQLLKREEERRQQ-RLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQ 631

Query: 116  DLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQ---RHTEMIHNYME 172
             L    E  E + +QL  + +   +Q  + EE E  L++     H+   R  E+     E
Sbjct: 632  QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQE 691

Query: 173  HL-ERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQ 231
               ER K        QLES A +R  K       ++  P              +  G  +
Sbjct: 692  QARERIKSRIPKWQWQLESEADARQSK-------VYSRPR-------------KQEGQRR 731

Query: 232  WKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTD 291
             + QE  + R  + L+        +  ++E++  D +    +A   +      ++  P  
Sbjct: 732  RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQW-QAEEKSERGRQRLSARP-- 788

Query: 292  TPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPEL 351
             PL+E+ E  ++  +   + +     E +  Q  R       E +   E + +       
Sbjct: 789  -PLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQ 847

Query: 352  DMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE 411
             + ++  G +      +  E +   +    L EE       L         L    R+ +
Sbjct: 848  QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQL----RKEQ 903

Query: 412  NLILENTQLL---ETKNALNIVKNDLIAKVDELTCEKDVL---------QGELEAVKQAK 459
             L+ E  + L   E +      +     + ++L  E++ L         + E E   +  
Sbjct: 904  QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963

Query: 460  LKLEEKNREL--EEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQ 517
             KL++K  +L  EE  ++ R E E   +K +++++      Q  R  R +  R   ER  
Sbjct: 964  KKLQQKEEQLLGEEPEKRRRQERE---KKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020

Query: 518  YKERLMELQEAVRWTEMIRASRENPAMQEKKR-----SSIWQFFSRLFSSSSNTTKKPEP 572
             K+  ++ +E     +++R  RE   +QE++R       + Q   +L      T ++ E 
Sbjct: 1021 RKKDELQQEE----EQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE- 1075

Query: 573  PVNLKYNAPTS---------HVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRRE 623
             +  +Y                 P  ++R     Q   ++      L +E E  L   RE
Sbjct: 1076 -LERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEE-----LQQEEEQLLREERE 1129

Query: 624  QKR-----EQYRQVKAHVQKED 640
            ++R      QYR+ +   Q+E+
Sbjct: 1130 KRRRQELERQYREEEEVQQEEE 1151



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 122/609 (20%), Positives = 237/609 (38%), Gaps = 82/609 (13%)

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLITQYER-EKALRKHAEEKFIEFEDSQEQEKKDL 117
            E  +    ++QE + E  L R + E+ + Q  R E+ LR+  EE+       ++  K++ 
Sbjct: 501  ERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER------REQLLKREE 554

Query: 118  QTRVESLESQTRQLELKAKNYADQISRLEE--REAELKKEY-NALHQRHTEMIHNYMEHL 174
            + R+E  E + ++L+ + +   DQ+ + EE  R+  LK+E    L QR           L
Sbjct: 555  EKRLEQ-ERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQR-----------L 602

Query: 175  ERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKF 234
            +R ++ +L   ++ E     R+++E P           +        K  E     Q + 
Sbjct: 603  KREEVERLEQEERRE----QRLKREEP-----------EEERRQQLLKSEEQEERRQQQL 647

Query: 235  QELSQPRSHTSLKVSNSPEPQKAVEQ--EDELSDVSQGGSKATTPASTANSDVATIPTDT 292
            +   Q R    LK     E ++ +EQ  + E  +  +    A      A   + +     
Sbjct: 648  RREQQERREQRLK---REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKW 704

Query: 293  PLKEENEGFV---KVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTP 349
              + E+E      KV   P K E  +  + Q  +  R  S    + EE++  Q       
Sbjct: 705  QWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQ-----QQ 759

Query: 350  ELDMDKDLS-GYKGSSTPTKGIENKAF------DRNTESLFEELSSAGSGLIGDVDEGAD 402
            E +  +D +  ++      +G +  +        R  +   EE        + + +E   
Sbjct: 760  EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQ 819

Query: 403  LLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKL 462
                 RE E    +  Q LE +  L   +     +  +L  E+D LQ + E  +  + + 
Sbjct: 820  RRRQRRERE----KELQFLEEEEQLQRRE-----RAQQLQEEEDGLQEDQERRRSQEQRR 870

Query: 463  EEKNR-ELEEELRKAR-------AEAEDAR--QKAKDDDDSDIPTAQRKRFTRVEMARVL 512
            ++K R +LEEE ++ R       A  E  R  Q+   +++ ++   +R++  R E  R  
Sbjct: 871  DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930

Query: 513  MERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEP 572
             E    +E+L + +E +   E  +  R+    Q +K   + Q   +L        ++ E 
Sbjct: 931  RE----EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER 986

Query: 573  PVNLKYNAPTSHVTPSV--KKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYR 630
                +           +  ++R     Q    + +  D L +E E  L   RE++R Q R
Sbjct: 987  EKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046

Query: 631  QVKAHVQKE 639
            + +   ++E
Sbjct: 1047 ERQYREEEE 1055



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 142/728 (19%), Positives = 269/728 (36%), Gaps = 112/728 (15%)

Query: 59  ENLDSVFAQDQEHQVELE--LLRDDNEQLITQ--------YEREKALRKHAEEKF----I 104
           E  D VF +++E +      +LR + E+L  +         E E+ LRK   ++      
Sbjct: 232 ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQ 291

Query: 105 EFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHT 164
           E E  Q++ +++ Q R +  E +  Q E + +    +  + E RE +L++E     +R  
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQ---EERRE 348

Query: 165 EMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGG 224
           + +    E   R    Q    +Q E     ++R+E+ +          +  L  + Q   
Sbjct: 349 QQLRREQEEERR---EQQLRREQEEERREQQLRREQQL--------RREQQLRREQQLRR 397

Query: 225 ETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSD 284
           E     + + +   Q R    L+     E Q   EQE+E  +      +           
Sbjct: 398 EQQLRREQQLRREQQLRREQQLR----REQQLRREQEEERHEQKHEQERREQRLKRE--- 450

Query: 285 VATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAI 344
                     +EE   ++K      + E  +H      QE R       + EE+ E    
Sbjct: 451 ----------QEERRDWLK-----REEETERH-----EQERRKQQLKRDQEEERRERWLK 490

Query: 345 IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLL 404
           +E     +  +            +  +        E L + L S    L  + +E  + L
Sbjct: 491 LEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRREQEERREQL 549

Query: 405 GMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEE 464
            + RE E  + +  +    K      ++ L+ + +E   ++  L+ E E   + +LK EE
Sbjct: 550 -LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQR--LKREQEERLEQRLKREE 606

Query: 465 KNRELEEELRKARAE----AEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKE 520
             R  +EE R+ R +     E+ RQ+    ++ +    Q+ R  + E     ++R + +E
Sbjct: 607 VERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEE 666

Query: 521 RL-----MELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVN 575
           RL      E +E  R  E+    +E    + K R   WQ+  +L S +     K      
Sbjct: 667 RLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQW--QLESEADARQSK------ 718

Query: 576 LKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYR----Q 631
             Y+ P        K+      Q   +K +  +   +  E   A R++Q+ EQ R    Q
Sbjct: 719 -VYSRPR-------KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770

Query: 632 VKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAV 691
            +A  + E GR Q      P + ++    + E + +      +L   +EK+   +     
Sbjct: 771 WQAEEKSERGR-QRLSARPPLREQRERQLRAEERQQR--EQRFLPEEEEKEQRRR----- 822

Query: 692 GVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQ 751
                  + R+           K++  L+ E   QR      L + +  L+E Q+  ++Q
Sbjct: 823 -----QRRERE-----------KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQ 866

Query: 752 EELSSLVW 759
           E+     W
Sbjct: 867 EQRRDQKW 874



 Score = 44.3 bits (103), Expect = 8e-04
 Identities = 40/200 (20%), Positives = 88/200 (44%), Gaps = 7/200 (3%)

Query: 69   QEHQVELELLRD----DNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESL 124
            QE Q +L   RD    ++EQL+ + E ++  R+  + KF+E E    +++++ Q R    
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLR-HDR 1665

Query: 125  ESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSG 184
            + + R+ E   +   +Q  R +ER+ + ++E   L ++  E    +++  ++ +  +L  
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERE--RKFLQEEQQLRRQELER 1723

Query: 185  SDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHT 244
              + E        +E+      +     +  L P+ ++          KF+E  Q R   
Sbjct: 1724 KFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQER 1783

Query: 245  SLKVSNSPEPQKAVEQEDEL 264
              +   S E  +   +E++L
Sbjct: 1784 EEQQLRSQESDRKFREEEQL 1803



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 25/86 (29%), Positives = 45/86 (52%), Gaps = 2/86 (2%)

Query: 83   EQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQI 142
            EQ +   ERE+ LR+  + KF E E    ++++D + R E  E Q R+ E + K   ++ 
Sbjct: 1396 EQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE--EQQVRRQERERKFLEEEQ 1453

Query: 143  SRLEEREAELKKEYNALHQRHTEMIH 168
               +ER  + ++E   L +R  + +H
Sbjct: 1454 QLRQERHRKFREEEQLLQEREEQQLH 1479



 Score = 41.2 bits (95), Expect = 0.007
 Identities = 117/625 (18%), Positives = 246/625 (39%), Gaps = 72/625 (11%)

Query: 41   RYDEEVVKELMPLVVAVLENLDSVFAQDQEHQV-ELELLRDDNEQLITQYEREKALRKHA 99
            R +EE+ +E   L+    E  +    Q+ E Q  + + L+ + EQL+ + EREK   +  
Sbjct: 991  REEEELQQEEEQLL---REEREKRRRQEWERQYRKKDELQQEEEQLLRE-EREKRRLQER 1046

Query: 100  EEKFIEFEDSQEQEKKDL-----QTRVESLESQTRQLELKAKNYADQISRLE-------E 147
            E ++ E E+ Q++E++ L       R + LE Q R+ E + +   +Q+ R E       E
Sbjct: 1047 ERQYREEEELQQEEEQLLGEERETRRRQELERQYRK-EEELQQEEEQLLREEPEKRRRQE 1105

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
            RE + ++E   L Q   +++    E   R +L +    ++       ++ +E P      
Sbjct: 1106 RERQCREE-EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEP------ 1158

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDV 267
                         +K        Q++ +E  Q      L+       Q+   Q  E  ++
Sbjct: 1159 -------------EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEEL 1205

Query: 268  SQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRN 327
             +   K         SD+       P KE      KV     ++E  + +E         
Sbjct: 1206 QRQKRKQRYRDEDQRSDLKW--QWEPEKENAVRDNKVYCKGRENEQFRQLE--------- 1254

Query: 328  VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELS 387
              +   + + + ++Q ++    E D +++   ++         E    +   E+   +  
Sbjct: 1255 -DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313

Query: 388  SAGSGLIGDVDEGADLLGMGREVENLILENTQLLETK--NALNIVKNDLIAKVDELTCEK 445
            S     +  + E  +     +E +    E  QLL+ +    L   + D   + +EL  ++
Sbjct: 1314 SQEEKQL--LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371

Query: 446  DVLQGELEAVKQAKLKLEEKNRE-LEEELRKARAEAEDARQKAKD----DDDSDIPTAQR 500
               QG     ++ +L+ +E+ R+ L+EE +    E E   ++ +D    +++  +   +R
Sbjct: 1372 ---QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428

Query: 501  KRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIW-QFFSRL 559
             R  R E  +V   R + + + +E ++ +R     +   E   +QE++   +  Q   R 
Sbjct: 1429 DRKFREEEQQV--RRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK 1486

Query: 560  FSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLA 619
            F       ++ E   + K+           +K      QL   + +   FL EE +    
Sbjct: 1487 FLEEEQQLRRQER--DRKFREQELRSQEPERKFLEEEQQLHRQQRQR-KFLQEEQQL--- 1540

Query: 620  SRREQKREQYRQVKAHVQKEDGRVQ 644
             RR+++ +Q RQ +    +E+ +++
Sbjct: 1541 -RRQERGQQRRQDRDRKFREEEQLR 1564



 Score = 37.7 bits (86), Expect = 0.073
 Identities = 87/507 (17%), Positives = 186/507 (36%), Gaps = 48/507 (9%)

Query: 62  DSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRV 121
           + ++ Q QE Q E E  R + EQL       ++ + H  E+F + E  + +E  +L+ + 
Sbjct: 171 EELWRQRQEWQ-EREERRAEEEQL-------QSCKGHETEEFPDEEQLRRRELLELRRKG 222

Query: 122 ESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM---IHNYMEHLERTK 178
              + Q R+         ++     +RE  L+KE   L +   +    +    E L + +
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 179 LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELS 238
             +L    Q E     R+R+E+ +                + ++  +    EQ + +E  
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLR-----------RKQEEERREQQEERREQQERREQQ 331

Query: 239 QPRSHTSLKVSNSP--EPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKE 296
           + R    L+       E Q   EQE+E  +      +              +  +  L+ 
Sbjct: 332 EERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRR 391

Query: 297 ENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKD 356
           E +   +      + ++ +  +++  Q+ R       E EE+   Q   +   E  + ++
Sbjct: 392 EQQ-LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKRE 450

Query: 357 LSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILE 416
               +      +  E    +R  + L  +           ++E        R  + L  E
Sbjct: 451 QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRRE 510

Query: 417 NTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKA 476
                E +    + + +   ++ +    +  L+ E E  ++  LK EE+ R LE+E R+ 
Sbjct: 511 Q----EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKR-LEQERREQ 565

Query: 477 R--------------AEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERL 522
           R               E E  +Q+ K + +  +     +R  R E+ R+  E  + +   
Sbjct: 566 RLKREQEERRDQLLKREEERRQQRLKREQEERL----EQRLKREEVERLEQEERREQRLK 621

Query: 523 MELQEAVRWTEMIRASRENPAMQEKKR 549
            E  E  R  +++++  +    Q++ R
Sbjct: 622 REEPEEERRQQLLKSEEQEERRQQQLR 648



 Score = 37.4 bits (85), Expect = 0.096
 Identities = 30/135 (22%), Positives = 60/135 (44%), Gaps = 4/135 (2%)

Query: 68   DQEHQVELELLRD--DNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLE 125
            ++E Q+  E  R   + EQL+ + E ++  R+  + KF+E E    ++++D + R + L 
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELR 1509

Query: 126  SQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGS 185
            SQ  + E K      Q+ R + +   L++E     Q   +      +   R +       
Sbjct: 1510 SQ--EPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567

Query: 186  DQLESTAHSRIRKER 200
            ++ + +   R RK R
Sbjct: 1568 EEQQLSRQERDRKFR 1582



 Score = 36.2 bits (82), Expect = 0.21
 Identities = 39/225 (17%), Positives = 88/225 (39%), Gaps = 10/225 (4%)

Query: 444 EKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRF 503
           E+++ +GE ++ KQ +L+  ++ R  EE  R+ +   E   ++A+++        + + F
Sbjct: 145 ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEF 204

Query: 504 TRVEMARVLMERNQYKERLMELQEAVRWT-EMIRASRENPAMQEKKRSSIWQFFSRLFSS 562
              E  R        +  L+EL+   R   +  R  R++   QE++    W+    +   
Sbjct: 205 PDEEQLR--------RRELLELRRKGREEKQQQRRERQDRVFQEEEEKE-WRKRETVLRK 255

Query: 563 SSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRR 622
                ++ EP    +       +    ++      Q    + +      +        RR
Sbjct: 256 EEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERR 315

Query: 623 EQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMK 667
           EQ+ E+  Q +   Q+E+ R Q       ++ +Q    + E + +
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERR 360



 Score = 35.8 bits (81), Expect = 0.28
 Identities = 41/181 (22%), Positives = 81/181 (44%), Gaps = 19/181 (10%)

Query: 32   YREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQE--HQVELELLRD--------D 81
            +RE E+ + R + E  K L        + L+  F ++++   + E E LR         +
Sbjct: 1693 FREEEQQLRRQERER-KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751

Query: 82   NEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQ 141
             EQL  + E ++  R+  + KF E E+   QE+++ Q R +  + + R+ E   +   +Q
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFRE-EEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810

Query: 142  ISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERP 201
              R ++R+ + + E   L     E      + L + +  Q    +Q  +   SR R+E+ 
Sbjct: 1811 QLRPQQRDGKYRWEEEQLQLEEQE------QRLRQERDRQYRAEEQFATQEKSR-REEQE 1863

Query: 202  I 202
            +
Sbjct: 1864 L 1864



 Score = 33.1 bits (74), Expect = 1.8
 Identities = 31/126 (24%), Positives = 57/126 (45%), Gaps = 20/126 (15%)

Query: 81   DNEQLITQYEREKALRKHAEEKFIEFEDS---QEQEKKDLQTRVESLESQTRQLELKAKN 137
            + EQL  + E ++  R+  + KF   E     QEQE+K ++   + L  Q  Q +L+   
Sbjct: 1559 EEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE-QQLRRQEGQQQLR--- 1614

Query: 138  YADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLH---QLSGSDQLESTAHS 194
                    +ER+ + +++   L +R  + +H   +  +R  L    QL   ++ +   H 
Sbjct: 1615 --------QERDRKFREDEQLLQEREEQQLHR--QERDRKFLEEEPQLRRQEREQQLRHD 1664

Query: 195  RIRKER 200
            R RK R
Sbjct: 1665 RDRKFR 1670



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 32/146 (21%), Positives = 62/146 (42%), Gaps = 6/146 (4%)

Query: 58  LENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDL 117
           L+  +    +DQE +   E  RD   +   Q E E+  R+H        ++   +E++ L
Sbjct: 849 LQEEEDGLQEDQERRRSQEQRRDQKWRW--QLEEERKRRRHTLYAKPALQEQLRKEQQLL 906

Query: 118 QTRVESL---ESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHL 174
           Q   E L   E + R+ + + + Y ++  +L++ E +L +E     +R         +  
Sbjct: 907 QEEEEELQREEREKRRRQEQERQYREE-EQLQQEEEQLLREEREKRRRQERERQYRKDKK 965

Query: 175 ERTKLHQLSGSDQLESTAHSRIRKER 200
            + K  QL G +  +     R +K R
Sbjct: 966 LQQKEEQLLGEEPEKRRRQEREKKYR 991


>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
          Length = 898

 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 115/602 (19%), Positives = 242/602 (40%), Gaps = 86/602 (14%)

Query: 62  DSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRV 121
           D + AQD   +  ++ L  +  Q + Q  ++    +  +E  +      E+E  DL+   
Sbjct: 270 DQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEK 329

Query: 122 ESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIH-------NYMEHL 174
           E+LE + R    + +   ++I +L + +  L + Y       T +I        +   H+
Sbjct: 330 ETLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHV 389

Query: 175 ERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKF 234
            + K  Q     +++S   ++ + +   +         D +             SE+ K 
Sbjct: 390 IKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKS 449

Query: 235 QELSQPRSHTSLKVSNSPEPQKAVEQED----------ELSDVSQGGSKATTPASTANSD 284
            EL        L+V+     ++  E+ D          EL D+ +   +      T  + 
Sbjct: 450 NELD-----AKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTK 504

Query: 285 VATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAI 344
           V  +  D  L+ E+E             +SK+ E+               N +K+E+Q +
Sbjct: 505 VKCLE-DERLRTEDE-------------LSKYKEII--------------NRQKAEIQNL 536

Query: 345 IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLL 404
           ++     D  ++              + +   +  E+L EE+ S  S LI D+ +  D+ 
Sbjct: 537 LDKVKTADQLQE--------------QLQRGKQEIENLKEEVESLNS-LINDLQK--DIE 579

Query: 405 GMGREVENLILENTQLLETKNA-LNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLE 463
           G  R+ E+ +L  T+ L +KNA L    N L ++ D+++C +  LQ + E +KQ  + LE
Sbjct: 580 G-SRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLE 638

Query: 464 EKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLM 523
            +  + EEELRK   +   A    +  +   + T Q +      + +     +  K+   
Sbjct: 639 SRLLK-EEELRKEEVQTLQAELACRQTEVKALST-QVEELKDELVTQRRKHASSIKDLTK 696

Query: 524 ELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTS 583
           +LQ+A R  + + +        +K+ SS+    S   S ++ ++ +   P N   +    
Sbjct: 697 QLQQARRKLDQVES-----GSYDKEVSSMGSRSSSSGSLNARSSAEDRSPENTGSSVAVD 751

Query: 584 HVTPSVKK-----RSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQK 638
           +  P V K     R   L +    K++  +F+ +  +  +    E+ R++ + +++++ +
Sbjct: 752 NF-PQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLV----EEIRKKTKIIQSYILR 806

Query: 639 ED 640
           E+
Sbjct: 807 EE 808



 Score = 37.4 bits (85), Expect = 0.096
 Identities = 90/468 (19%), Positives = 187/468 (39%), Gaps = 68/468 (14%)

Query: 34  EFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREK 93
           E  RLI   D+ + +++   V+ V    + + A+   H+   + L++   +L    E   
Sbjct: 370 ETTRLIREIDK-LKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEAD 428

Query: 94  ALRKHAEEKFIEFEDSQEQEKKDLQTRVE----SLESQTRQLELKAKNYADQISRLEERE 149
            +RK+ ++    +++S+E +  +L  ++      LE Q ++   + + +  +I  LE+ +
Sbjct: 429 QIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLK 488

Query: 150 AELKKEYNALHQRHTEM-------------IHNYMEHLERTK------LHQLSGSDQLES 190
              K+  + L    T++             +  Y E + R K      L ++  +DQL+ 
Sbjct: 489 RTFKEGMDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQE 548

Query: 191 TAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSN 250
                 ++   +   +  L +    L  D QK  +  GS + + + L      TS     
Sbjct: 549 QLQRGKQEIENLKEEVESLNS----LINDLQK--DIEGSRKRESELLLFTERLTSKNAQL 602

Query: 251 SPEPQKAVEQEDELS-DVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPN 309
             E      Q D++S   SQ  S+      T  +  + +  +  L++E    ++   A  
Sbjct: 603 QSESNSLQSQFDKVSCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACR 662

Query: 310 KSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKG 369
           ++E+ K +  QV +    + T     + +    +I + T +L           +      
Sbjct: 663 QTEV-KALSTQVEELKDELVT-----QRRKHASSIKDLTKQLQQ---------ARRKLDQ 707

Query: 370 IENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNI 429
           +E+ ++D+   S+    SS+GS            L      E+   ENT         + 
Sbjct: 708 VESGSYDKEVSSMGSRSSSSGS------------LNARSSAEDRSPENTG--------SS 747

Query: 430 VKNDLIAKVDE-LTCEKDVLQGELEAVKQAKLK-LEEKNRELEEELRK 475
           V  D   +VD+ +  E+ V   +  A K  K++ +E+  ++L EE+RK
Sbjct: 748 VAVDNFPQVDKAMLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRK 795



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 54/265 (20%), Positives = 108/265 (40%), Gaps = 29/265 (10%)

Query: 409 EVENLILENTQLLET-KNALNIVKNDLIAKVDELTCEKDVLQGELEAVK-QAKLKLEEKN 466
           E +NL  E  +  ET K  +N +K  L ++++EL  E    + +L A    AK  +++ +
Sbjct: 229 EKDNLREELKKRTETEKQHMNTIKQ-LESRIEELNKEVKASRDQLIAQDVTAKNAVQQLH 287

Query: 467 RELEEELRKARAEAEDARQKAK---------DDDDSDIPTAQRKRFTRVEMARVLMERN- 516
           +E+ + + +A  + E+ARQ+ +         + +  D+   +     ++  A   +E+N 
Sbjct: 288 KEMAQRMEQANKKCEEARQEKEAMVMKYVRGEKESLDLRKEKETLEKKLRDANKELEKNT 347

Query: 517 -------QYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSI----W---QFFSRLFSS 562
                  Q K RL +L E  +  E  R  RE   ++E   S +    W   +  + + S 
Sbjct: 348 NKIKQLSQEKGRLHQLYE-TKEGETTRLIREIDKLKEDINSHVIKVKWAQNKLKAEMDSH 406

Query: 563 SSNTTKKPEPPVNL-KYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASR 621
                K  E    L +       +  + +    T  +    KS   D     T+  L  +
Sbjct: 407 KETKDKLKETTTKLTQAKEEADQIRKNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQ 466

Query: 622 REQKREQYRQVKAHVQKEDGRVQAF 646
            ++K +Q     A +++ +   + F
Sbjct: 467 MQEKSDQLEMHHAKIKELEDLKRTF 491


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 161/797 (20%), Positives = 320/797 (40%), Gaps = 131/797 (16%)

Query: 20   MSERVSGLAGSIYREFERLIGRYDE-EVVKELMPLVVAVLENLDSVFA-------QDQEH 71
            ++++   L G++ R  +  + + +  +VV+EL   +  + E+ +S  A       Q ++ 
Sbjct: 1085 LAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDL 1144

Query: 72   QVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVE--------S 123
              ELE L+ + E  +     ++ LR   E++  E + + E+E K+ + +++        +
Sbjct: 1145 SEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATA 1204

Query: 124  LESQTRQLELKAKNYADQISR----LEEREAELKKEYNALHQRHTEMIHNYME-HLERTK 178
            LE  + QLE +AK +   + +    LE    EL  E   L Q   E  H   +   +  +
Sbjct: 1205 LEELSEQLE-QAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQE 1263

Query: 179  LH-QLSGSDQLE---STAHSRIRKERPISLGIFPLPAGDGL-LTPDAQKGGETPGSEQWK 233
            LH ++S  D+L    +   S+++ E      +       G+    DA          Q  
Sbjct: 1264 LHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQEL 1323

Query: 234  FQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGG---------SKATTPASTANSD 284
             QE ++ + + S ++    E + +++++ E  + ++           S+        + D
Sbjct: 1324 LQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDD 1383

Query: 285  VATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAI 344
            + TI +   L+E  +  +K  +A ++    K +     ++T+N                +
Sbjct: 1384 LGTIES---LEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN---------------RL 1425

Query: 345  IESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLL 404
             +   +L +D D      S+   K    K FD   + L EE S   S    +  + A+  
Sbjct: 1426 QQELDDLTVDLDHQRQVASNLEKK---QKKFD---QLLAEEKSI--SARYAEERDRAEAE 1477

Query: 405  GMGREVENLILENT--QLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKL 462
               +E + L L     + LE K         L A +++L   KD +   +        +L
Sbjct: 1478 AREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVH-------EL 1530

Query: 463  EEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERL 522
            E+  R LE+++ + R + E+   + +  +D+ +      +  + +  R L  R++  E  
Sbjct: 1531 EKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEK 1590

Query: 523  MELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPT 582
              L        +I+  RE  A  E +R        R  + +S    K +  ++LK     
Sbjct: 1591 KRL--------LIKQVRELEAELEDERK------QRALAVAS----KKKMEIDLK--DLE 1630

Query: 583  SHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRRE---QKREQYRQVKA----- 634
            + +  + K R   + QL   +++  D+   E E + ASR E   Q +E  +++K+     
Sbjct: 1631 AQIEAANKARDEVIKQLRKLQAQMKDY-QRELEEARASRDEIFAQSKESEKKLKSLEAEI 1689

Query: 635  -HVQKEDGRVQAFGWSLPQK----YKQVTNGQG-------ENKMKNLPVPVYLRPLDEKD 682
              +Q+E    +       Q+      ++TN          E +     +      L+E+ 
Sbjct: 1690 LQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQ 1749

Query: 683  TSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELK 742
            ++M+L     +N    KT               V  L+ E + +RSA+Q S D   Q+L+
Sbjct: 1750 SNMEL-----LNDRFRKTT------------LQVDTLNAELAAERSAAQKS-DNARQQLE 1791

Query: 743  EQQKELKNQ-EELSSLV 758
             Q KELK + +EL   V
Sbjct: 1792 RQNKELKAKLQELEGAV 1808



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 109/526 (20%), Positives = 215/526 (40%), Gaps = 57/526 (10%)

Query: 54   VVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKA-----LRKHAEEK--FIEF 106
            V  +LE  +    +  +    LE    D ++L+ +  R+K      +R+  EEK    E 
Sbjct: 1292 VSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQ 1351

Query: 107  EDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEM 166
            ++ +E+ +K+L+ +V +L+SQ    + K  +    I  LEE + +L K+  AL QR  E 
Sbjct: 1352 QEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEK 1411

Query: 167  IHNYMEHLERTKLHQLSGSDQL-------ESTAHSRIRKERPISLGIFPLPAGDGLLTPD 219
               Y + LE+TK       D L          A +  +K++     +    +       +
Sbjct: 1412 ALAY-DKLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEE 1470

Query: 220  AQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKA---VEQEDELSDVSQGGSKATT 276
              +       ++ K   L++     +L+     E Q      + ED +S     G     
Sbjct: 1471 RDRAEAEAREKETKALSLARALEE-ALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHE 1529

Query: 277  PASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENE 336
               +  +    +       EE E  ++ T+   K  +  +++   AQ  R++ T   +NE
Sbjct: 1530 LEKSKRALEQQVEEMRTQLEELEDELQATEDA-KLRLEVNMQAMKAQFERDLQTRDEQNE 1588

Query: 337  EKSE--VQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLI 394
            EK    ++ + E   EL+ ++       +S     I+ K    + E+  E  + A   +I
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLK----DLEAQIEAANKARDEVI 1644

Query: 395  GDVDE-GADLLGMGREVENLILENTQLL----ETKNALNIVKNDLIAKVDELTC------ 443
              + +  A +    RE+E       ++     E++  L  ++ +++   +EL        
Sbjct: 1645 KQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARR 1704

Query: 444  ----EKDVLQGEL-------EAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAK---- 488
                E+D L  E+        A+   K +LE +  +LEEEL + ++  E    + +    
Sbjct: 1705 HAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTL 1764

Query: 489  --DDDDSDIPTAQRKRFTRVEMARVLMER--NQYKERLMELQEAVR 530
              D  ++++  A+R    + + AR  +ER   + K +L EL+ AV+
Sbjct: 1765 QVDTLNAEL-AAERSAAQKSDNARQQLERQNKELKAKLQELEGAVK 1809



 Score = 57.4 bits (137), Expect = 9e-08
 Identities = 123/552 (22%), Positives = 218/552 (39%), Gaps = 86/552 (15%)

Query: 2    ELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDE---EVVKELMPLVVAVL 58
            +LE+ +  +E+          ++ G    +  +   L  + DE   ++ K+   L  A+ 
Sbjct: 1038 DLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA 1097

Query: 59   ENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQ 118
               D    ++   +V  EL     E L   +E EKA R  AE++  +  +  E  K +L+
Sbjct: 1098 RGDDETLHKNNALKVVRELQAQIAE-LQEDFESEKASRNKAEKQKRDLSEELEALKTELE 1156

Query: 119  TRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTK 178
               ++L++   Q EL+ K         E+  AELKK      + H   I + M     T 
Sbjct: 1157 ---DTLDTTAAQQELRTKR--------EQEVAELKKALEEETKNHEAQIQD-MRQRHATA 1204

Query: 179  LHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELS 238
            L +L  S+QLE     +   E+             GL T + +   E    +Q       
Sbjct: 1205 LEEL--SEQLEQAKRFKANLEK----------NKQGLETDNKELACEVKVLQQ------- 1245

Query: 239  QPRSHTSLKVSNSPEPQKAVEQEDEL-SDVSQGGSKATTPASTANSDVATIPTDTPLKEE 297
                   +K  +  + +K   Q  EL + VS+G       A  A+     +   + L EE
Sbjct: 1246 -------VKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEE 1298

Query: 298  NE--GFVKVTDAPNKSEISKHIEVQVAQETR---NVSTGSAE-NEEKSEVQAIIESTPEL 351
             E  G     DA +     +  +  + +ETR   N+S+   +  EEK+ +Q   E   E 
Sbjct: 1299 AEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEA 1358

Query: 352  --DMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGRE 409
              +++K +   +     TK    K  D +  ++ E L  A   L+ D +       + + 
Sbjct: 1359 RKNLEKQVLALQSQLADTK----KKVDDDLGTI-ESLEEAKKKLLKDAE------ALSQR 1407

Query: 410  VENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 469
            +E   L   +L +TKN L         ++D+LT        +L+  +Q    LE+K ++ 
Sbjct: 1408 LEEKALAYDKLEKTKNRLQ-------QELDDLTV-------DLDHQRQVASNLEKKQKKF 1453

Query: 470  EEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAV 529
            ++ L    AE +    +  ++ D     A+ K    + +AR L E  + KE      E  
Sbjct: 1454 DQLL----AEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKE------EFE 1503

Query: 530  RWTEMIRASREN 541
            R  + +RA  E+
Sbjct: 1504 RQNKQLRADMED 1515



 Score = 55.8 bits (133), Expect = 3e-07
 Identities = 131/650 (20%), Positives = 252/650 (38%), Gaps = 88/650 (13%)

Query: 31   IYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYE 90
            + R+ E L  + DEE++K        V E    V  + +E + + + L ++   L  Q +
Sbjct: 847  VTRQEEELQAK-DEELLK--------VKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897

Query: 91   REKALRKHAEE---KFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEE 147
             E  L   AEE   +    +   E+   DL++RVE  E + + L+ + K     I  LEE
Sbjct: 898  AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEE 957

Query: 148  REAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIF 207
               +L +E  A  +   E +          K+ ++     L    +S+  KE+       
Sbjct: 958  ---QLDEEEGARQKLQLEKV------TAEAKIKKMEEEILLLEDQNSKFIKEKK------ 1002

Query: 208  PLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQ-EDELSD 266
                   L+     +       E+ K + L++ R+   + +S+  E  K  E+   EL  
Sbjct: 1003 -------LMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEK 1055

Query: 267  VSQGGSKATT----PASTANSDVATIPTDTPLKEEN------EGFVKVTDAPNKSEISKH 316
              +     TT      +   + +  +      KEE        G  +     N  ++ + 
Sbjct: 1056 AKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRE 1115

Query: 317  IEVQVAQ-----ETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIE 371
            ++ Q+A+     E+   S   AE +++   + +     EL+   D +  +      +  E
Sbjct: 1116 LQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQE 1175

Query: 372  ----NKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNAL 427
                 KA +  T++   ++          ++E ++ L   +  +  + +N Q LET N  
Sbjct: 1176 VAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQGLETDN-- 1233

Query: 428  NIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELE------EELRKARAEAE 481
                        EL CE  VLQ      +  + KL+ + +EL       + LR   AE  
Sbjct: 1234 -----------KELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKA 1282

Query: 482  DARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLME--------LQEAVRWTE 533
               Q   D+  + +  A++K     + A  L  + Q  + L++        L   +R  E
Sbjct: 1283 SKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLE 1342

Query: 534  MIRAS-RENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKR 592
              + S +E    +E+ R ++ +    L S  ++T KK +   +L            + K 
Sbjct: 1343 EEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDD--DLGTIESLEEAKKKLLKD 1400

Query: 593  SSTLSQLPGDKSKAFDFLSEETEASLASRREQ---KREQYRQVKAHVQKE 639
            +  LSQ   +K+ A+D L E+T+  L    +      +  RQV ++++K+
Sbjct: 1401 AEALSQRLEEKALAYDKL-EKTKNRLQQELDDLTVDLDHQRQVASNLEKK 1449



 Score = 47.8 bits (112), Expect = 7e-05
 Identities = 171/790 (21%), Positives = 310/790 (39%), Gaps = 167/790 (21%)

Query: 11   EEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQE 70
            EE G    +  E+V+          E  I + +EE++         +LE+ +S F +  E
Sbjct: 961  EEEGARQKLQLEKVTA---------EAKIKKMEEEIL---------LLEDQNSKFIK--E 1000

Query: 71   HQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQ 130
             ++  + + + + QL  + E+ K L K   ++ +   D +E+ KK+ +TR E LE   R+
Sbjct: 1001 KKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQE-LEKAKRK 1059

Query: 131  LELKAKNYADQISRLEEREAEL------------KKE---YNALHQRHTEMIH--NYMEH 173
            L+ +  +  DQI       AEL            KKE     AL +   E +H  N ++ 
Sbjct: 1060 LDGETTDLQDQI-------AELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKV 1112

Query: 174  LERTKLHQLSGSDQLESTAHSRIRKE---RPIS--LGIFPLPAGDGLLTPDAQKGGETPG 228
            +   +       +  ES   SR + E   R +S  L        D L T  AQ       
Sbjct: 1113 VRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQ------- 1165

Query: 229  SEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATI 288
                  QEL   R     ++  + E ++    E ++ D+ Q  + A    S         
Sbjct: 1166 ------QELRTKREQEVAELKKALE-EETKNHEAQIQDMRQRHATALEELSEQLEQAKRF 1218

Query: 289  PTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEK-----SEVQA 343
              +  L++  +G     +  NK E++   EV+V Q+ +      AE+E K     ++VQ 
Sbjct: 1219 KAN--LEKNKQGL----ETDNK-ELA--CEVKVLQQVK------AESEHKRKKLDAQVQE 1263

Query: 344  IIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADL 403
            +     E D  +     K S      ++N+    N  +L EE    G   I    + A L
Sbjct: 1264 LHAKVSEGDRLRVELAEKASK-----LQNEL--DNVSTLLEEAEKKG---IKFAKDAASL 1313

Query: 404  LGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLE 463
                ++ + L+ E     ET+  LN     L +++ +L  EK+ LQ + E  ++A+  LE
Sbjct: 1314 ESQLQDTQELLQE-----ETRQKLN-----LSSRIRQLEEEKNSLQEQQEEEEEARKNLE 1363

Query: 464  EKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMER-------- 515
            ++   L+ +L   +        K  DDD   I + +  +   ++ A  L +R        
Sbjct: 1364 KQVLALQSQLADTK--------KKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAY 1415

Query: 516  ---NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEP 572
                + K RL   QE    T  +   R+  +  EKK+    Q  +             E 
Sbjct: 1416 DKLEKTKNRLQ--QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAE------------EK 1461

Query: 573  PVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQV 632
             ++ +Y           ++R    ++    ++KA   L+   E +L ++ E +R Q +Q+
Sbjct: 1462 SISARY----------AEERDRAEAEAREKETKALS-LARALEEALEAKEEFER-QNKQL 1509

Query: 633  KAHVQKEDGRVQAFGWSLP--QKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCA 690
            +A ++         G ++   +K K+    Q E     L         DE   +      
Sbjct: 1510 RADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLE-----ELEDELQATEDAKLR 1564

Query: 691  VGVNLSGGK--------TRDGGSVVGASVFYKDVAGLDTE---GSKQRSASQSSLDKLDQ 739
            + VN+   K        TRD  +     +  K V  L+ E     KQR+ + +S  K++ 
Sbjct: 1565 LEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEI 1624

Query: 740  ELKEQQKELK 749
            +LK+ + +++
Sbjct: 1625 DLKDLEAQIE 1634



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 41/178 (23%), Positives = 75/178 (42%), Gaps = 29/178 (16%)

Query: 44   EEVVKELMPLVVAVLE----------NLDSVFAQDQEHQVELELLRDDNEQLITQYEREK 93
            +EV+K+L  L   + +          + D +FAQ +E + +L+ L  +  QL  +    +
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSE 1700

Query: 94   ALRKHAEEKFIEFED----------SQEQEKKDLQTRV----ESLESQTRQLELKAKNYA 139
              R+HAE++  E  D          +   EK+ L+ R+    E LE +   +EL    + 
Sbjct: 1701 RARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFR 1760

Query: 140  DQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIR 197
                +++   AEL  E +A      +   N  + LER      +   +LE    S+ +
Sbjct: 1761 KTTLQVDTLNAELAAERSA-----AQKSDNARQQLERQNKELKAKLQELEGAVKSKFK 1813



 Score = 33.9 bits (76), Expect = 1.1
 Identities = 62/296 (20%), Positives = 115/296 (38%), Gaps = 65/296 (21%)

Query: 354  DKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENL 413
            D++L   K   T  +G E +  +R  + L EE +     L  + +  A+   M       
Sbjct: 858  DEELLKVKEKQTKVEG-ELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEM------- 909

Query: 414  ILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEEL 473
                 +L   K  L  + +DL ++V+E      +LQ E       K K++   ++LEE+L
Sbjct: 910  ---RARLAAKKQELEEILHDLESRVEEEEERNQILQNE-------KKKMQAHIQDLEEQL 959

Query: 474  RKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTE 533
                 E E ARQK +                        +E+   + ++ +++E +    
Sbjct: 960  ----DEEEGARQKLQ------------------------LEKVTAEAKIKKMEEEI---- 987

Query: 534  MIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNL-----KYNAPTSHVTPS 588
            ++   + +  ++EKK         R+   SS   ++ E   NL     K     S +   
Sbjct: 988  LLLEDQNSKFIKEKKLME-----DRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEER 1042

Query: 589  VKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQ 644
            +KK   T  +L   K K    L  ET   L  +  + + Q  ++K  + K++  +Q
Sbjct: 1043 LKKEEKTRQELEKAKRK----LDGET-TDLQDQIAELQAQIDELKLQLAKKEEELQ 1093



 Score = 32.7 bits (73), Expect = 2.4
 Identities = 89/459 (19%), Positives = 182/459 (39%), Gaps = 68/459 (14%)

Query: 48   KELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYER-EKALRKHAEEKF--- 103
            K+L   +  ++ + D V     E +     L    E++ TQ E  E  L+   + K    
Sbjct: 1507 KQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLE 1566

Query: 104  IEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKE--YNALHQ 161
            +  +  + Q ++DLQTR E  E + R L          I ++ E EAEL+ E    AL  
Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLL----------IKQVRELEAELEDERKQRALAV 1616

Query: 162  RHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQ 221
               + +   ++ LE     Q+  +++       ++RK +   +  +     +   + D +
Sbjct: 1617 ASKKKMEIDLKDLEA----QIEAANKARDEVIKQLRKLQA-QMKDYQRELEEARASRD-E 1670

Query: 222  KGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQE-----DELSDVSQGGSKATT 276
               ++  SE+ K + L         ++++S   ++  EQE     DE+++ + G S    
Sbjct: 1671 IFAQSKESEK-KLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLD 1729

Query: 277  PASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAE-N 335
                  + +A +  +  L+EE      + D   K+             T  V T +AE  
Sbjct: 1730 EKRRLEARIAQLEEE--LEEEQSNMELLNDRFRKT-------------TLQVDTLNAELA 1774

Query: 336  EEKSEVQAIIESTPELD-MDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLI 394
             E+S  Q    +  +L+  +K+L             + +  +   +S F+   SA    I
Sbjct: 1775 AERSAAQKSDNARQQLERQNKELKA-----------KLQELEGAVKSKFKATISALEAKI 1823

Query: 395  GDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEA 454
            G ++E  +     R   N ++  T+             ++  +V++     D  + ++E 
Sbjct: 1824 GQLEEQLEQEAKERAAANKLVRRTEKK---------LKEIFMQVEDERRHADQYKEQME- 1873

Query: 455  VKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDS 493
              +A  ++++  R+LEE   +A       R+  ++ DD+
Sbjct: 1874 --KANARMKQLKRQLEEAEEEATRANASRRKLQRELDDA 1910


>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
            sapiens]
          Length = 1939

 Score = 62.0 bits (149), Expect = 4e-09
 Identities = 138/704 (19%), Positives = 268/704 (38%), Gaps = 140/704 (19%)

Query: 83   EQLITQYEREKALRKHAEEKFIEFEDSQEQEKKD---LQTRVESLESQTRQLELKAKNYA 139
            +++  + E E+ +      K  + ED   + KKD   L+  +  +E +    E K KN  
Sbjct: 924  KEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLT 983

Query: 140  DQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKE 199
            ++++ L+E  A+L KE  AL + H + + +             +  D++ +   ++I+ E
Sbjct: 984  EEMAGLDETIAKLTKEKKALQEAHQQTLDDLQ-----------AEEDKVNTLTKAKIKLE 1032

Query: 200  RPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVE 259
            + +                                             +  S E +K + 
Sbjct: 1033 QQVD-------------------------------------------DLEGSLEQEKKIR 1049

Query: 260  QEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEV 319
             + E +     G       ST + +      D  LK++     +++   +K E  + + +
Sbjct: 1050 MDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKE---FEMSGLQSKIEDEQALGM 1106

Query: 320  QVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNT 379
            Q+ ++ + +     E EE+ E +    +  E     DLS                  R  
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAERASRAKAE-KQRSDLS------------------REL 1147

Query: 380  ESLFEELSSAGSGLIGDVD----EGADLLGMGREVENLILEN---------------TQL 420
            E + E L  AG      ++      A+   M R++E   L++                +L
Sbjct: 1148 EEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAEL 1207

Query: 421  LETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA 480
             E  + L  VK  L  +  E+  E D L   +E V +AK  LE+  R LE++L + + + 
Sbjct: 1208 GEQIDNLQRVKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKE 1267

Query: 481  EDARQKAKDDDDSDIPTAQRKRFTRV--EMARVLMERNQYKERLMELQEAVRWTEMIRAS 538
            E+ ++   D       TAQR R      E +R L E++    +L   ++A  +T+ I   
Sbjct: 1268 EEQQRLIND------LTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQA--FTQQIEEL 1319

Query: 539  RENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQ 598
            +     + K +S++    +    SS +           +  A  + +  ++ K +S ++Q
Sbjct: 1320 KRQLEEEIKAKSAL----AHALQSSRHDCDLLREQYEEEQEA-KAELQRAMSKANSEVAQ 1374

Query: 599  LPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVT 658
                          + E     R E+  E  +++   +Q  +  V+A         K  T
Sbjct: 1375 -----------WRTKYETDAIQRTEELEEAKKKLAQRLQDAEEHVEAVNAKCASLEK--T 1421

Query: 659  NGQGENKMKNLPVPV-----YLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFY 713
              + +N++++L + V         LD+K  +     A        K  +  + + AS   
Sbjct: 1422 KQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQ----KCEETHAELEAS--Q 1475

Query: 714  KDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSL 757
            K+   L TE  K ++A + SLD+L + LK + K L  Q+E+S L
Sbjct: 1476 KESRSLSTELFKIKNAYEESLDQL-ETLKRENKNL--QQEISDL 1516



 Score = 43.1 bits (100), Expect = 0.002
 Identities = 99/476 (20%), Positives = 190/476 (39%), Gaps = 95/476 (19%)

Query: 44   EEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKF 103
            EE  K+L   +    E++++V A+    +   + L+++ E L+   ER  A     ++K 
Sbjct: 1391 EEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQ 1450

Query: 104  IEFED---SQEQEKKDLQTRVESLESQTRQLE---LKAKN-YADQISRLEEREAELKKEY 156
              F+      +Q+ ++    +E+ + ++R L     K KN Y + + +LE     LK+E 
Sbjct: 1451 RNFDKILAEWKQKCEETHAELEASQKESRSLSTELFKIKNAYEESLDQLET----LKREN 1506

Query: 157  NALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLL 216
              L Q  +++     E  +R  +H+L    +      S ++                   
Sbjct: 1507 KNLQQEISDLTEQIAEGGKR--IHELEKIKKQVEQEKSELQAA----------------- 1547

Query: 217  TPDAQKGGETPGSEQWKFQ-ELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKAT 275
              +A+   E    +  + Q EL+Q +S    K++         E+++E+  + +   +  
Sbjct: 1548 LEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA---------EKDEEIDQMKRNHIRIV 1598

Query: 276  -TPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS-KHIEVQVAQETRNVSTGSA 333
             +  ST ++++ +      LK++ EG +      N+ EI   H     A+  RN      
Sbjct: 1599 ESMQSTLDAEIRSRNDAIRLKKKMEGDL------NEMEIQLNHANRMAAEALRNYRN--- 1649

Query: 334  ENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSA---- 389
                    QAI++ T +L +D  L   +        +E +A     E   EEL +     
Sbjct: 1650 -------TQAILKDT-QLHLDDALRSQEDLKEQLAMVERRANLLQAE--IEELRATLEQT 1699

Query: 390  -GSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDV- 447
              S  I +     +LL     V+ L  +NT L+ TK  L                E D+ 
Sbjct: 1700 ERSRKIAE----QELLDASERVQLLHTQNTSLINTKKKL----------------ETDIS 1739

Query: 448  -LQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKR 502
             +QGE+E + Q       + R  EE+ +KA  +A    ++ K + D+     + K+
Sbjct: 1740 QIQGEMEDIIQ-------EARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 95/504 (18%), Positives = 194/504 (38%), Gaps = 72/504 (14%)

Query: 68   DQEHQVELELLRDDNEQLITQYEREKA-LRKHAEEKFIEFEDSQEQEKKDLQTRVESLES 126
            +++ + E + +R D E+   Q+E   A LRK   +   E  +  +    +LQ   + LE 
Sbjct: 1168 NKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQID----NLQRVKQKLEK 1223

Query: 127  QTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSD 186
            +  +++++  + A  +  + + +  L+K   AL  + +E+     E  ++  ++ L+   
Sbjct: 1224 EKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEI--KTKEEEQQRLINDLTAQR 1281

Query: 187  ---QLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQ-KGGETPGSEQWKFQELSQPRS 242
               Q ES  +SR   E+            D L++  ++ K   T   E+ K Q   + ++
Sbjct: 1282 ARLQTESGEYSRQLDEK------------DTLVSQLSRGKQAFTQQIEELKRQLEEEIKA 1329

Query: 243  HTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT----IPTDTPLKEEN 298
             ++L  +            ++  +  +  ++     S ANS+VA       TD   + E 
Sbjct: 1330 KSALAHALQSSRHDCDLLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEE 1389

Query: 299  EGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIEST---------P 349
                K   A    +  +H+E   A+      T      E  ++   +E T          
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKK 1449

Query: 350  ELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGRE 409
            + + DK L+ +K     T   E +A  + + SL  EL                      +
Sbjct: 1450 QRNFDKILAEWKQKCEETHA-ELEASQKESRSLSTELF---------------------K 1487

Query: 410  VENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNREL 469
            ++N   E+   LET    N      I+ + E   E      ELE +K          +++
Sbjct: 1488 IKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKIK----------KQV 1537

Query: 470  EEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMER----NQYKERLMEL 525
            E+E  + +A  E+A    + ++   +         + E+ R + E+    +Q K   + +
Sbjct: 1538 EQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRI 1597

Query: 526  QEAVRWTEMIRASRENPAMQEKKR 549
             E+++ T        N A++ KK+
Sbjct: 1598 VESMQSTLDAEIRSRNDAIRLKKK 1621



 Score = 39.7 bits (91), Expect = 0.019
 Identities = 103/525 (19%), Positives = 215/525 (40%), Gaps = 77/525 (14%)

Query: 2    ELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLEN- 60
            E+ED ++  E    + A + ++         R F++++  + ++  +    L  +  E+ 
Sbjct: 1428 EVEDLMIDVERTNAACAALDKK--------QRNFDKILAEWKQKCEETHAELEASQKESR 1479

Query: 61   -----LDSVFAQDQEHQVELELLRDDNEQL------ITQYEREKALRKHAEEKFIEFEDS 109
                 L  +    +E   +LE L+ +N+ L      +T+   E   R H  EK    +  
Sbjct: 1480 SLSTELFKIKNAYEESLDQLETLKRENKNLQQEISDLTEQIAEGGKRIHELEKI---KKQ 1536

Query: 110  QEQEKKDLQTRVESLESQTRQLE---LKAKNYADQI-SRLEEREAELKKEYNALHQRHTE 165
             EQEK +LQ  +E  E+     E   L+ +   +Q+ S ++ + AE  +E + + + H  
Sbjct: 1537 VEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIR 1596

Query: 166  MIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGL--------LT 217
            ++ +    L+  ++   + + +L+      +  E  I L      A + L        + 
Sbjct: 1597 IVESMQSTLD-AEIRSRNDAIRLKKKMEGDLN-EMEIQLNHANRMAAEALRNYRNTQAIL 1654

Query: 218  PDAQKG-GETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQ--------EDELSDVS 268
             D Q    +   S++   ++L+      +L  +   E +  +EQ        E EL D S
Sbjct: 1655 KDTQLHLDDALRSQEDLKEQLAMVERRANLLQAEIEELRATLEQTERSRKIAEQELLDAS 1714

Query: 269  QGGSKATTPASTANSDVATIPTD-TPLKEENEGFVKVTDAPNKSEISKHI---EVQVAQE 324
            +      T  ++  +    + TD + ++ E E  ++  +A N  E +K        +A+E
Sbjct: 1715 ERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIIQ--EARNAEEKAKKAITDAAMMAEE 1772

Query: 325  TRNVSTGSA--ENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESL 382
             +     SA  E  +K+  Q + +    LD  + L+  KG     + +E +  +   E  
Sbjct: 1773 LKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLA-LKGGKKQIQKLEARVRELEGEVE 1831

Query: 383  FEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELT 442
             E+  +        V+    L    R+V+ L  +  +  + KN L +   DL+       
Sbjct: 1832 SEQKRN--------VEAVKGLRKHERKVKELTYQTEE--DRKNILRL--QDLV------- 1872

Query: 443  CEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKA 487
               D LQ ++++ K+   + EE++     + R+ + E E+A ++A
Sbjct: 1873 ---DKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEERA 1914



 Score = 37.0 bits (84), Expect = 0.13
 Identities = 158/807 (19%), Positives = 292/807 (36%), Gaps = 163/807 (20%)

Query: 72   QVELELLRDDNEQLITQYEREKALRKHAEEKFIEFE---------------------DSQ 110
            Q +++ L+   E+L  + E E+A R  AE++  +                       +  
Sbjct: 1109 QKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQIEMN 1168

Query: 111  EQEKKDLQTRVESLESQTRQLELKA----KNYADQISRLEEREAELKKEYNALHQRHTEM 166
            ++ + + Q     LE  T Q E  A    K +AD ++ L E+   L++    L +  +EM
Sbjct: 1169 KKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVKQKLEKEKSEM 1228

Query: 167  ------IHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDA 220
                  + + ME + + K +       LE        KE      I  L A    L  ++
Sbjct: 1229 KMEIDDLASNMETVSKAKGNLEKMCRALEDQLSEIKTKEEEQQRLINDLTAQRARLQTES 1288

Query: 221  QKGGETPGSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQE------------------- 261
             +       +     +LS+ +   + ++    E ++ +E+E                   
Sbjct: 1289 GEYSRQLDEKDTLVSQLSRGKQAFTQQIE---ELKRQLEEEIKAKSALAHALQSSRHDCD 1345

Query: 262  ---DELSDVSQGGSKATTPASTANSDVA----TIPTDTPLKEENEGFVKVTDAPNKSEIS 314
               ++  +  +  ++     S ANS+VA       TD   + E     K   A    +  
Sbjct: 1346 LLREQYEEEQEAKAELQRAMSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDAE 1405

Query: 315  KHIEVQVAQETRNVSTGSAENEEKSEVQAIIEST---------PELDMDKDLSGYKGSST 365
            +H+E   A+      T      E  ++   +E T          + + DK L+ +K    
Sbjct: 1406 EHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCE 1465

Query: 366  PTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLE--- 422
             T   E +A  + + SL  EL    +     +D+   L  + RE +NL  E + L E   
Sbjct: 1466 ETHA-ELEASQKESRSLSTELFKIKNAYEESLDQ---LETLKRENKNLQQEISDLTEQIA 1521

Query: 423  -----------TKNALNIVKNDLIAKVDELTCEKDVLQG-------ELEAVK-QAKLKLE 463
                        K  +   K++L A ++E     +  +G       EL  VK +   K+ 
Sbjct: 1522 EGGKRIHELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIA 1581

Query: 464  EKNRELEEELR---------------KARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEM 508
            EK+ E+++  R               + R+  +  R K K + D +    Q     R+  
Sbjct: 1582 EKDEEIDQMKRNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAA 1641

Query: 509  ARVLMERNQ---YKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSN 565
              +   RN     K+  + L +A+R  E +   +E  AM E++ + +      L ++   
Sbjct: 1642 EALRNYRNTQAILKDTQLHLDDALRSQEDL---KEQLAMVERRANLLQAEIEELRATLEQ 1698

Query: 566  TTKK----------PEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETE 615
            T +               V L +   TS +  + KK  + +SQ+ G+     D + E   
Sbjct: 1699 TERSRKIAEQELLDASERVQLLHTQNTSLIN-TKKKLETDISQIQGEME---DIIQE--- 1751

Query: 616  ASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYL 675
               A   E+K ++     A + +E             K +Q T+   E   KNL   V  
Sbjct: 1752 ---ARNAEEKAKKAITDAAMMAEE------------LKKEQDTSAHLERMKKNLEQTV-- 1794

Query: 676  RPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLD 735
                 KD   +L  A  + L GGK +    +       +++ G      K+   +   L 
Sbjct: 1795 -----KDLQHRLDEAEQLALKGGKKQ----IQKLEARVRELEGEVESEQKRNVEAVKGLR 1845

Query: 736  KLDQELKE----QQKELKNQEELSSLV 758
            K ++++KE     +++ KN   L  LV
Sbjct: 1846 KHERKVKELTYQTEEDRKNILRLQDLV 1872



 Score = 34.7 bits (78), Expect = 0.62
 Identities = 48/271 (17%), Positives = 115/271 (42%), Gaps = 27/271 (9%)

Query: 408  REVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNR 467
            +E+ N+  E  +  E        + +L  K+  L  EK+ LQ +++A   +    EE+  
Sbjct: 851  KEMANMKEEFEKTKEELAKTEAKRKELEEKMVTLMQEKNDLQLQVQAEADSLADAEERCD 910

Query: 468  ELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVE--------------MARVLM 513
            +L +   +  A+ ++  ++A+D+++ +     +KR    E              +A+V  
Sbjct: 911  QLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEK 970

Query: 514  ERNQYKERLMELQEAVRWTE--MIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPE 571
            E++  + ++  L E +   +  + + ++E  A+QE  + ++    +       NT  K  
Sbjct: 971  EKHATENKVKNLTEEMAGLDETIAKLTKEKKALQEAHQQTLDDLQAE--EDKVNTLTK-- 1026

Query: 572  PPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFD--FLSEETEASLASRREQKREQY 629
                +K       +  S+++       L   K K      L++E+   + + ++Q  E+ 
Sbjct: 1027 --AKIKLEQQVDDLEGSLEQEKKIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKL 1084

Query: 630  RQVKAHVQKEDGRV---QAFGWSLPQKYKQV 657
            ++ +  +     ++   QA G  L +K K++
Sbjct: 1085 KKKEFEMSGLQSKIEDEQALGMQLQKKIKEL 1115


>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
          Length = 1417

 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 80/375 (21%), Positives = 159/375 (42%), Gaps = 55/375 (14%)

Query: 411  ENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELE 470
            + L ++N  L ET    N++    + +  ++  ++ +  GELE     + KLE++  +LE
Sbjct: 888  KELKIKNHSLQETSEQ-NVILQHTLQQQQQMLQQETIRNGELE---DTQTKLEKQVSKLE 943

Query: 471  EELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMA----RVLMERNQYKERLMELQ 526
            +EL+K R  + +  +K ++  +S    A  KR   +E+     +V +E +QYKE L +++
Sbjct: 944  QELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKME 1003

Query: 527  EAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVT 586
            + +     ++   EN AM   +   I           +N  K+ E    L+++  T  +T
Sbjct: 1004 KEIM---HLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELE---KLQHSTET-ELT 1056

Query: 587  PSVKKR--------------SSTLSQLPGDK---SKAFDFLSEE--TEASLASRREQKRE 627
             +++KR               STL QL   +    KA   L E+  T   L +   + + 
Sbjct: 1057 EALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKM 1116

Query: 628  QYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTN---------GQGENKMKNLPVPVYLRPL 678
            +    K  + + D  ++   W L Q+  QVT+         G+ E K+  L   +    L
Sbjct: 1117 EIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSEL 1176

Query: 679  DEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLD 738
            + K+      C   +     K ++    +    F      +  +  ++ S  +  +++  
Sbjct: 1177 ELKE------CNKQIESLNDKLQNAKEQLREKEF------IMLQNEQEISQLKKEIERTQ 1224

Query: 739  QELKEQQKELKNQEE 753
            Q +KE +  +K QE+
Sbjct: 1225 QRMKEMESVMKEQEQ 1239



 Score = 55.1 bits (131), Expect = 4e-07
 Identities = 153/790 (19%), Positives = 299/790 (37%), Gaps = 140/790 (17%)

Query: 11  EEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQE 70
           ++   S  ++ E++  L   +  + + L  R  E  +++   +V+   ++L       QE
Sbjct: 280 QQQAASVPILEEQIINLEAEVSAQDKVL--REAENKLEQSQKMVIEKEQSL-------QE 330

Query: 71  HQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQ 130
            + E   L+ D  +   Q +R +  R  A     E   + +Q KK +  ++E ++++   
Sbjct: 331 SKEECIKLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEI 390

Query: 131 LELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLES 190
           LE    N   +  RL+ER    K E   L ++  ++        E+ ++  +  S+ +  
Sbjct: 391 LERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQ 450

Query: 191 TAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSN 250
              SR    + I      L   D +L                KF  +++ R    ++V+ 
Sbjct: 451 LTESR----QSILKLESELENKDEILRD--------------KFSLMNENRE-LKVRVAA 491

Query: 251 SPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGF--------- 301
             E     +QE E S V                 +  I +  PLK E  GF         
Sbjct: 492 QNERLDLCQQEIESSRVEL-------------RSLEKIISQLPLKRELFGFKSYLSKYQM 538

Query: 302 -----------------------VKVTDAPNKSEISK-HIEVQVAQETRNVSTGSAENEE 337
                                  +++  A  ++EI K H  +   Q ++++ T + +++E
Sbjct: 539 SSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCN-DSQE 597

Query: 338 KSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDV 397
            S++ ++     +L   +     K  +  T    NK +++  + L   +    + LI   
Sbjct: 598 SSKLSSLETEPVKLGGHQVAESVKDQNQHTM---NKQYEKERQRLVTGIEELRTKLIQIE 654

Query: 398 DEGADL-LGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVK 456
            E +DL + M        L   +LLE  +  + +++++  K  +L      L+ +LE   
Sbjct: 655 AENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLL----TLEKQLEEKI 710

Query: 457 QAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMA-RVLMER 515
            A   +  KN ELE+EL +   +            +++I T   K     E A ++ +E+
Sbjct: 711 VAYSSIAAKNAELEQELMEKNEKIRSL--------ETNINTEHEKICLAFEKAKKIHLEQ 762

Query: 516 NQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQ----------FFSRLFSSSSN 565
           ++  E+ +E  EA      +    +    QEK  S + Q             RL + S  
Sbjct: 763 HKEMEKQIERLEA-----QLEKKDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKG 817

Query: 566 TTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQK 625
             KK     N+K +     +   V + +  + QL      A +   EE            
Sbjct: 818 EMKKE----NMKKDEALKALQNQVSEETIKVRQL----DSALEICKEE------------ 857

Query: 626 REQYRQVKAHVQKEDGRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSM 685
                 +  H+ + +G  + F   L +K ++V   Q E K+KN      L+   E++  +
Sbjct: 858 ------LVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS----LQETSEQNVIL 907

Query: 686 KLWCAVGVNLSGGKT-RDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQ--ELK 742
           +        +   +T R+G      +   K V+ L+ E  KQR +S   L K+++  E  
Sbjct: 908 QHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESA 967

Query: 743 EQQKELKNQE 752
             + +LK Q+
Sbjct: 968 AHEADLKRQK 977



 Score = 40.0 bits (92), Expect = 0.015
 Identities = 109/527 (20%), Positives = 213/527 (40%), Gaps = 87/527 (16%)

Query: 58   LENLDSVFAQDQEHQVELELLRDDNEQLITQYERE-KALRKHAEEKFIEFEDSQEQ--EK 114
            L+    +  Q+     ELE  +   E+ +++ E+E +  R+ + EK  + E+  E    +
Sbjct: 911  LQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRKMEEKCESAAHE 970

Query: 115  KDLQT-RVESLESQTRQLELKAKNYADQISRLEEREAELKK--EYNALHQRHTEMIHNYM 171
             DL+  +V  L    RQ++++   Y +++S++E+    LK+  E  A+H    +MI    
Sbjct: 971  ADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMHLSQLDMI---- 1026

Query: 172  EHLERTKLH---QLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPG 228
              L++TK     + +   +LE   H                                   
Sbjct: 1027 --LDQTKTELEKKTNAVKELEKLQH----------------------------------- 1049

Query: 229  SEQWKFQELSQPRSHTSLKVSNS-PEPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT 287
            S + +  E  Q R     ++ N+  E +  + Q  EL DV Q    +     T   D+  
Sbjct: 1050 STETELTEALQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA 1109

Query: 288  IPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIES 347
                    E  E  +++ D   K E+   +E+  A + RN        +       I E 
Sbjct: 1110 --------ELRECKMEIED--KKQEL---LEMDQALKERNWELKQRAAQVTHLDMTIREH 1156

Query: 348  TPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMG 407
              E  M++ +   +G+   ++ +E K  ++  ESL ++L +A   L    ++   +L   
Sbjct: 1157 RGE--MEQKIIKLEGTLEKSE-LELKECNKQIESLNDKLQNAKEQL---REKEFIMLQNE 1210

Query: 408  REVENL--ILENTQ--LLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLE 463
            +E+  L   +E TQ  + E ++ +   +  +  +  E       L+   E V+ +  +L 
Sbjct: 1211 QEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLTREQVQNSHTELA 1270

Query: 464  EKNR---ELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVE----MARVLMERN 516
            E      + + E+ +  +E ED +Q +K+ D      A+    ++V      AR+  E  
Sbjct: 1271 EARHQQVQAQREIERLSSELEDMKQLSKEKDAHGNHLAEELGASKVREAHLEARMQAEIK 1330

Query: 517  QYKERLMELQEAVRWTEMIRASRENPA----MQEKKRSSIWQFFSRL 559
            +    +  L+EA    EMI + +EN A      + ++SS+ Q   +L
Sbjct: 1331 KLSAEVESLKEAYH-MEMI-SHQENHAKWKISADSQKSSVQQLNEQL 1375



 Score = 34.3 bits (77), Expect = 0.81
 Identities = 107/513 (20%), Positives = 195/513 (38%), Gaps = 87/513 (16%)

Query: 58   LENLDSVFAQDQEHQVELELLRDD---------NEQLITQYEREKALRKHAEEKFIEFED 108
            LE+LD +  + +    +  + +D+         +E+ I   + + AL    EE  +    
Sbjct: 805  LESLDRLLTESKGEMKKENMKKDEALKALQNQVSEETIKVRQLDSALEICKEELVLHLNQ 864

Query: 109  SQ-EQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMI 167
             +  +EK + Q + +S E    Q ELK KN++     L+E       E N + Q HT   
Sbjct: 865  LEGNKEKFEKQLKKKSEEVYCLQKELKIKNHS-----LQE-----TSEQNVILQ-HTLQQ 913

Query: 168  HNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETP 227
               M   E  +      + +LE T   + + E+ +S            L  + QK  E+ 
Sbjct: 914  QQQMLQQETIR------NGELEDT---QTKLEKQVS-----------KLEQELQKQRESS 953

Query: 228  GSEQWKFQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVAT 287
              +  K +E  +  +H +       + QK +E       V     +     S    ++  
Sbjct: 954  AEKLRKMEEKCESAAHEA-----DLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMH 1008

Query: 288  IPTDTPLKEENEGFVKVTDAPNKSEISKHIEV--QVAQETRNVSTGSAENEEKSEVQAII 345
            +  D   K  +   + +     K+E+ K      ++ +   +  T   E  +K EV    
Sbjct: 1009 LKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREV---- 1064

Query: 346  ESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLG 405
                   ++ +L    G        E K+  R  + L + L  A   L        DL  
Sbjct: 1065 -------LETELQNAHG--------ELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTA 1109

Query: 406  MGREVENLILENTQ-LLETKNAL---NIVKNDLIAKVDELTCEKDVLQGELE-------- 453
              RE +  I +  Q LLE   AL   N       A+V  L       +GE+E        
Sbjct: 1110 ELRECKMEIEDKKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEG 1169

Query: 454  AVKQAKLKLEEKNRELEEELRKARAEAEDARQK-----AKDDDDSDI-PTAQRKRFTRVE 507
             +++++L+L+E N+++E    K +   E  R+K       + + S +    +R +    E
Sbjct: 1170 TLEKSELELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKE 1229

Query: 508  MARVLMERNQYKERLMELQEAVRWTEMIRASRE 540
            M  V+ E+ QY     + +EA+   + +R +RE
Sbjct: 1230 MESVMKEQEQY--IATQYKEAIDLGQELRLTRE 1260



 Score = 31.2 bits (69), Expect = 6.9
 Identities = 49/262 (18%), Positives = 107/262 (40%), Gaps = 37/262 (14%)

Query: 58   LENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDL 117
            +E+L+      +E   E E +   NEQ I+Q ++E    +  +++  E E   +++++ +
Sbjct: 1185 IESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKE---IERTQQRMKEMESVMKEQEQYI 1241

Query: 118  QTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLER- 176
             T+ +      ++L L  +   +  + L E      +      QR  E + + +E +++ 
Sbjct: 1242 ATQYKEAIDLGQELRLTREQVQNSHTELAE-----ARHQQVQAQREIERLSSELEDMKQL 1296

Query: 177  TKLHQLSGSDQLESTAHSRIRK---ERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWK 233
            +K     G+   E    S++R+   E  +   I  L A    L             E + 
Sbjct: 1297 SKEKDAHGNHLAEELGASKVREAHLEARMQAEIKKLSAEVESL------------KEAYH 1344

Query: 234  FQELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTP 293
             + +S   +H   K+S       A  Q+  +  +++   KA      A   V+ +     
Sbjct: 1345 MEMISHQENHAKWKIS-------ADSQKSSVQQLNEQLEKAKLELEEAQDTVSNL--HQQ 1395

Query: 294  LKEENEGFVKVTDAPNKSEISK 315
            +++ NE    V +A N++ ++K
Sbjct: 1396 VQDRNE----VIEAANEALLTK 1413


>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
            sapiens]
          Length = 1940

 Score = 59.7 bits (143), Expect = 2e-08
 Identities = 138/713 (19%), Positives = 283/713 (39%), Gaps = 101/713 (14%)

Query: 90   EREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEERE 149
            E+E A  K   +K  +     E ++K+L+ ++ +L  +   L+L+ +  ++ +   EER 
Sbjct: 847  EKEMATMKEEFQKTKDELAKSEAKRKELEEKLVTLVQEKNDLQLQVQAESENLLDAEERC 906

Query: 150  AELKKEYNALHQRHTEMIHNYMEHLE-----RTKLHQLSGS--------DQLEST----- 191
             +L K    L  +  E+     +  E       K  +L           D LE T     
Sbjct: 907  DQLIKAKFQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVE 966

Query: 192  --AHSRIRKERPISLGIFPLPAGDGLLTPDA-------QKGGETPGSEQWKFQELSQPRS 242
               H+   K + ++  +  L      LT +        Q+  +   +E+ K   L++ +S
Sbjct: 967  KEKHATENKVKNLTEELSGLDETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKS 1026

Query: 243  HTSLKVSNSPEPQKAVEQEDELS-DVSQGGSKATTPASTANSDVATIPTDTPLKEENEGF 301
                +V    + + ++EQE +L  D+ +   K       A   +  +  D    +E    
Sbjct: 1027 KLEQQVE---DLESSLEQEKKLRVDLERNKRKLEGDLKLAQESILDLENDKQQLDER--- 1080

Query: 302  VKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYK 361
                    K +  ++ ++Q   E    + G    ++  E+QA IE     ++++++   +
Sbjct: 1081 -------LKKKDFEYCQLQSKVEDEQ-TLGLQFQKKIKELQARIE-----ELEEEIEAER 1127

Query: 362  GSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVD----EGADLLGMGREVENLILEN 417
             +   T+  +   + R  E L E L  AG      ++      A+ L + R++E   L++
Sbjct: 1128 ATRAKTEK-QRSDYARELEELSERLEEAGGVTSTQIELNKKREAEFLKLRRDLEEATLQH 1186

Query: 418  ---------------TQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKL 462
                            +L E  + L  VK  L  +  E   E D L   +E+V ++K  L
Sbjct: 1187 EAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLEIDDLSSSMESVSKSKANL 1246

Query: 463  EEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRV-EMARVLMERNQYKER 521
            E+  R LE++L +AR + E+ ++       S++ T + +  T   E++R L E+     +
Sbjct: 1247 EKICRTLEDQLSEARGKNEEIQRSL-----SELTTQKSRLQTEAGELSRQLEEKESIVSQ 1301

Query: 522  LMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAP 581
            L   ++A  +T+     +     + K ++++               ++ E     K    
Sbjct: 1302 LSRSKQA--FTQQTEELKRQLEEENKAKNALAHALQSSRHDCDLLREQYEEEQEGK---- 1355

Query: 582  TSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDG 641
             + +  ++ K +S ++Q              + E     R E+  E  +++   +Q  + 
Sbjct: 1356 -AELQRALSKANSEVAQ-----------WRTKYETDAIQRTEELEEAKKKLAQRLQDSEE 1403

Query: 642  RVQAFGWSLP--QKYKQVTNGQGENKMKNLPVPVYL-RPLDEKDTSMKLWCAVGVNLSGG 698
            +V+A        +K KQ   G+ E+ M ++     L   LD+K  +          L+  
Sbjct: 1404 QVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNF------DKVLAEW 1457

Query: 699  KTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQ 751
            KT+   S        K+   L TE  K ++A + +LD+L + +K + K L+ +
Sbjct: 1458 KTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQL-ETVKRENKNLEQE 1509



 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 131/668 (19%), Positives = 271/668 (40%), Gaps = 62/668 (9%)

Query: 36   ERLIGRYDEEVVKELMPLVVAVLENL-DSVFAQDQEHQVELELLRDDNEQLITQYEREKA 94
            E+L+    E+   +L   V A  ENL D+    DQ  + + +L     E +  + E E+ 
Sbjct: 876  EKLVTLVQEK--NDLQLQVQAESENLLDAEERCDQLIKAKFQLEAKIKE-VTERAEDEEE 932

Query: 95   LRKHAEEKFIEFEDSQEQEKKD---LQTRVESLESQTRQLELKAKNYADQISRLEEREAE 151
            +      K  + ED   + KKD   L+  +  +E +    E K KN  +++S L+E  A+
Sbjct: 933  INAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVKNLTEELSGLDETIAK 992

Query: 152  LKKEYNALHQRHTEMI------HNYMEHLERTK------LHQLSGSDQLESTAHSRIRKE 199
            L +E  AL + H + +       + +  L +TK      +  L  S + E      + + 
Sbjct: 993  LTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLEQQVEDLESSLEQEKKLRVDLERN 1052

Query: 200  RPISLGIFPLPAGDGL-LTPDAQKGGETPGSEQWKFQEL-SQPRSHTSLKVSNSPEPQKA 257
            +    G   L     L L  D Q+  E    + +++ +L S+     +L +    + ++ 
Sbjct: 1053 KRKLEGDLKLAQESILDLENDKQQLDERLKKKDFEYCQLQSKVEDEQTLGLQFQKKIKEL 1112

Query: 258  VEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHI 317
              + +EL +  +             SD A    +   + E  G V  T    + E++K  
Sbjct: 1113 QARIEELEEEIEAERATRAKTEKQRSDYARELEELSERLEEAGGVTST----QIELNKKR 1168

Query: 318  EVQVAQETRNVSTGSAENE------EKSEVQAIIESTPELD--------MDKDLSGYKGS 363
            E +  +  R++   + ++E       K    ++ E   ++D        ++K+ S +K  
Sbjct: 1169 EAEFLKLRRDLEEATLQHEAMVAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFK-- 1226

Query: 364  STPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLET 423
                  +E      + ES+ +  ++         D+ ++  G   E++  +   ++L   
Sbjct: 1227 ------LEIDDLSSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSL---SELTTQ 1277

Query: 424  KNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQA-KLKLEEKNRELEEELRKARAEAED 482
            K+ L     +L  +++    EK+ +  +L   KQA   + EE  R+LEEE  KA+     
Sbjct: 1278 KSRLQTEAGELSRQLE----EKESIVSQLSRSKQAFTQQTEELKRQLEEE-NKAKNALAH 1332

Query: 483  ARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQ--YKERLMELQEAVRWTEMIRASRE 540
            A Q ++ D D      + ++  + E+ R L + N    + R     +A++ TE +  +++
Sbjct: 1333 ALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKK 1392

Query: 541  NPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPV-NLKYNAPTSH-VTPSVKKRSSTLSQ 598
              A + +      +  +   +S   T ++ +  V +L  +   ++ +  ++ K+     +
Sbjct: 1393 KLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDK 1452

Query: 599  LPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED--GRVQAFGWSLPQKYKQ 656
            +  +     +    E EASL   R    E ++   A+ +  D    V+    +L Q+   
Sbjct: 1453 VLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIAD 1512

Query: 657  VTNGQGEN 664
            +T    EN
Sbjct: 1513 LTEQIAEN 1520



 Score = 42.0 bits (97), Expect = 0.004
 Identities = 127/625 (20%), Positives = 240/625 (38%), Gaps = 127/625 (20%)

Query: 65   FAQDQEHQVELE--LLRDDNE--QLITQYEREKALR----KHAEEKFIE-FEDSQEQ--- 112
            + ++QE + EL+  L + ++E  Q  T+YE +   R    + A++K  +  +DS+EQ   
Sbjct: 1348 YEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEA 1407

Query: 113  -----------------EKKDLQTRVESLESQTRQLELKAKNY----ADQISRLEEREAE 151
                             E +DL   VE   S    L+ K +N+    A+  ++ EE +AE
Sbjct: 1408 VNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAE 1467

Query: 152  LK---KEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFP 208
            L+   KE  +L     ++ + Y E L           DQLE+        E+ I+  +  
Sbjct: 1468 LEASLKESRSLSTELFKLKNAYEEAL-----------DQLETVKRENKNLEQEIA-DLTE 1515

Query: 209  LPAGDGLLTPDAQKGGETPGSE----QWKFQELSQPRSHTSLKVSN---------SPEPQ 255
              A +G    + +K  +    E    Q   +E      H   K+           S   +
Sbjct: 1516 QIAENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDR 1575

Query: 256  KAVEQEDELSDVSQGGSKAT-TPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEIS 314
            K  E+++E+  + +   +   T  S  +++V +      LK++ EG +            
Sbjct: 1576 KIAEKDEEIEQLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLN----------- 1624

Query: 315  KHIEVQVAQETRNVSTGSAEN-EEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENK 373
              IE+Q++   R     +AE  +    VQ  ++ T +L +D  L G              
Sbjct: 1625 -EIEIQLSHANRQ----AAETLKHLRSVQGQLKDT-QLHLDDALRGQ------------- 1665

Query: 374  AFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNIVKND 433
                  E L E+L+         V+  A+LL    EVE L      L +T+ A  + + +
Sbjct: 1666 ------EDLKEQLAI--------VERRANLLQA--EVEEL---RATLEQTERARKLAEQE 1706

Query: 434  LIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDS 493
            L+   + +     +L  +  ++   K KLE    +L+ E+  A  +A +A +KAK     
Sbjct: 1707 LLDSNERV----QLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITD 1762

Query: 494  DIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIW 553
                A+  +  +   A +   +   ++ + +LQ  +   E + A +      +K  + I 
Sbjct: 1763 AAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQL-ALKGGKKQIQKLETRIR 1821

Query: 554  QFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEE 613
            +    L       T+  +     KY      +T   ++    + +L          L ++
Sbjct: 1822 ELEFELEGEQKKNTESVKG--LRKYERRVKELTYQSEEDRKNVLRLQD--------LVDK 1871

Query: 614  TEASLASRREQKREQYRQVKAHVQK 638
             +  + S + Q  E   Q  AH+ K
Sbjct: 1872 LQVKVKSYKRQAEEADEQANAHLTK 1896


>gi|38044112 restin isoform b [Homo sapiens]
          Length = 1392

 Score = 57.8 bits (138), Expect = 7e-08
 Identities = 105/512 (20%), Positives = 199/512 (38%), Gaps = 68/512 (13%)

Query: 57   VLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEE--KFIEFEDSQEQEK 114
            V++N  S     +E  ++L+ LR  + +  ++ ++ +   + AE+  K +E E + E  K
Sbjct: 712  VIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSK 771

Query: 115  KDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHL 174
                TR    E Q R  ELK  N  + +S + + +  L+KE   L ++  E         
Sbjct: 772  ASSITR----ELQGR--ELKLTNLQENLSEVSQVKETLEKELQILKEKFAE--------- 816

Query: 175  ERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKF 234
                   +S    ++ T +   +KE   +           +L+ D +K  E     + KF
Sbjct: 817  --ASEEAVSVQRSMQETVNKLHQKEEQFN-----------MLSSDLEKLRENLADMEAKF 863

Query: 235  QELSQPRSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPL 294
            +E  + R    +K           + E++++++ +     ++  +  N ++     D   
Sbjct: 864  REKDE-REEQLIKAKE--------KLENDIAEIMKMSGDNSSQLTKMNDELRLKERDV-- 912

Query: 295  KEENEGFVKVTDA-PNKSEISKHIE-VQVAQETRNVSTGSAENEEKSEVQAIIESTPELD 352
                E  +K+T A  N S + K IE + V  E           EEK E++  +      D
Sbjct: 913  ---EELQLKLTKANENASFLQKSIEDMTVKAEQSQQEAAKKHEEEKKELERKLS-----D 964

Query: 353  MDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVEN 412
            ++K +          K    +A         E L +    L+   D+   L G   E   
Sbjct: 965  LEKKMETSHNQCQELKARYERATSETKTKHEEILQNLQKTLLDTEDK---LKGAREENSG 1021

Query: 413  LILENTQLLETKNALNIVK--NDLIAKVDELTCEKDVLQGELEAVKQAKLKLE------- 463
            L+ E  +L +  +     +   D +  ++++T EK      LE  KQ   KL+       
Sbjct: 1022 LLQELEELRKQADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1081

Query: 464  EKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERN-QYKERL 522
            E N +  EEL K++ E      +  ++   +I T ++    + +    L E N +  E L
Sbjct: 1082 ENNLKNVEELNKSK-ELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEENVKLAEEL 1140

Query: 523  MELQEAVRWTEMIRASR---ENPAMQEKKRSS 551
               ++ V   + +   R    N  ++ KKR S
Sbjct: 1141 GRSRDEVTSHQKLEEERSVLNNQLLEMKKRES 1172



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 147/721 (20%), Positives = 275/721 (38%), Gaps = 119/721 (16%)

Query: 58   LENLDSVFAQDQE---HQVELELLRDDNEQLITQYERE-KALRKHAEEKFIEFEDSQEQE 113
            +ENL +   QD E   H  E+E LR    ++I + E   +A+R     K  + ED    E
Sbjct: 628  IENLQN--QQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRS----KLDKAEDQHLVE 681

Query: 114  KKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEH 173
             +D   +++  E + ++LE+      +Q                      T++I N+   
Sbjct: 682  MEDTLNKLQEAEIKVKELEVLQAKCNEQ----------------------TKVIDNFTSQ 719

Query: 174  LERT--KLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTP-DAQKGGETPGSE 230
            L+ T  KL  L    +  S   S ++K R        L A +  +   + +K  E+    
Sbjct: 720  LKATEEKLLDLDALRKASSEGKSEMKKLRQ------QLEAAEKQIKHLEIEKNAESS--- 770

Query: 231  QWKFQELSQPRSHTSLKVSNSPEPQKAVEQ-----EDELSDVSQGGSKATTPASTANSDV 285
              K   +++      LK++N  E    V Q     E EL  + +  ++A+  A +    +
Sbjct: 771  --KASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSM 828

Query: 286  ATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSE-VQAI 344
                     KEE    +        S++ K  E        N++   A+  EK E  + +
Sbjct: 829  QETVNKLHQKEEQFNML-------SSDLEKLRE--------NLADMEAKFREKDEREEQL 873

Query: 345  IESTPELDMD----KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG 400
            I++  +L+ D      +SG   S       E +  +R+ E L  +L+ A        +E 
Sbjct: 874  IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKA--------NEN 925

Query: 401  ADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVK---- 456
            A  L    E   +  E +Q  E        K +L  K+ +L  + +    + + +K    
Sbjct: 926  ASFLQKSIEDMTVKAEQSQ-QEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 984

Query: 457  QAKLKLEEKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQ--RKRFTRVEMARVLME 514
            +A  + + K+ E+ + L+K   + ED  + A++++   +   +  RK+  + + A     
Sbjct: 985  RATSETKTKHEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKAA----- 1039

Query: 515  RNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPV 574
              Q  E  M++ E     +M +   E  A  E  + +  +  + L +   N  K  E  +
Sbjct: 1040 --QTAEDAMQIME-----QMTKEKTETLASLEDTKQTNAKLQNELDTLKENNLKNVE-EL 1091

Query: 575  NLKYNAPT--SHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQV 632
            N      T  +      +K   TL Q    KS+    L EE    LA    + R+   +V
Sbjct: 1092 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRSRD---EV 1147

Query: 633  KAHVQKEDGRVQAFGWSLPQKYKQ---VTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWC 689
             +H + E+ R       L  K ++   + +   E       + +    L EKD  ++   
Sbjct: 1148 TSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELE--- 1204

Query: 690  AVGVNLSGGKTRDGGSVVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELK 749
                 L    T   G    A   +  V  L+++  K     +  +  L+ +LKE +++L 
Sbjct: 1205 ----KLRNEVTVLRGENASAKSLHSVVQTLESDKVK----LELKVKNLELQLKENKRQLS 1256

Query: 750  N 750
            +
Sbjct: 1257 S 1257



 Score = 50.4 bits (119), Expect = 1e-05
 Identities = 83/429 (19%), Positives = 165/429 (38%), Gaps = 53/429 (12%)

Query: 74   ELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLEL 133
            E+  +  DN   +T+   E  L++   E+         +    LQ  +E +  +  Q + 
Sbjct: 886  EIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSIEDMTVKAEQSQQ 945

Query: 134  KA-KNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLESTA 192
            +A K + ++   LE + ++L+K+    H +  E+   Y      TK            T 
Sbjct: 946  EAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETK------------TK 993

Query: 193  HSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQPRSHTSLKVSNSP 252
            H  I +    +L          L T D  KG     S     QEL + R           
Sbjct: 994  HEEILQNLQKTL----------LDTEDKLKGAREENSGL--LQELEELRKQA-------- 1033

Query: 253  EPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEE----NEGFVKVTDAP 308
            +  KA +  ++   + +  +K  T    +  D  T  T+  L+ E     E  +K  +  
Sbjct: 1034 DKAKAAQTAEDAMQIMEQMTKEKTETLASLED--TKQTNAKLQNELDTLKENNLKNVEEL 1091

Query: 309  NKSEISKHIEVQVAQETRN-VSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPT 367
            NKS+    +E Q  +E R  + T      +KS+  + ++    + + ++L   +   T  
Sbjct: 1092 NKSKELLTVENQKMEEFRKEIETLKQAAAQKSQQLSALQEE-NVKLAEELGRSRDEVTSH 1150

Query: 368  KGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVENLIL--ENTQLLETKN 425
            + +E +    N + L  E+    S  I D DE    L     + + +L  ++ +L + +N
Sbjct: 1151 QKLEEERSVLNNQLL--EMKKRESKFIKDADEEKASLQKSISITSALLTEKDAELEKLRN 1208

Query: 426  ALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEAEDARQ 485
             + +++ +              L   ++ ++  K+KLE K + LE +L++ + +   +  
Sbjct: 1209 EVTVLRGE--------NASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSG 1260

Query: 486  KAKDDDDSD 494
                  D D
Sbjct: 1261 NTDTQADED 1269



 Score = 35.4 bits (80), Expect = 0.36
 Identities = 133/708 (18%), Positives = 257/708 (36%), Gaps = 134/708 (18%)

Query: 70  EHQVELELLRDDNEQLITQYERE----KALRKHAEEKFIEFEDSQEQEKK---DLQTRVE 122
           E + EL L RD ++Q + + E +    + + + A+ + +E  +  E+EK+   DLQ RVE
Sbjct: 387 EIEQELALARDGHDQHVLELEAKMDQLRTMVEAADREKVELLNQLEEEKRKVEDLQFRVE 446

Query: 123 SLESQTRQLELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQL 182
                   LE+   +   +I  LE+  A   +E   L +R           LE  K    
Sbjct: 447 EESITKGDLEVATVSEKSRIMELEKDLALRVQEVAELRRR-----------LESNK---- 491

Query: 183 SGSDQLESTAHSRIRKERPISLGIFPLPAGD-----GLLTPDAQKGGETPGSEQWKFQEL 237
                                      PAGD      LL   +    +   +     +E+
Sbjct: 492 ---------------------------PAGDVDMSLSLLQEISSLQEKLEVTRTDHQREI 524

Query: 238 SQPRSHTSLKVSNSPEPQKAV-EQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKE 296
           +  + H   +     +  KA+    ++LS  ++        A+  NSDV           
Sbjct: 525 TSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDV----------- 573

Query: 297 ENEGFVKVTDAPNKSEISKHIEVQVAQETRNVSTGSAENEEKSEVQAIIESTPELDMD-- 354
                + +  +  ++ I+ H   Q A E   VS       E +E   +     ++ +D  
Sbjct: 574 -----IALWKSKLETAIASH---QQAMEELKVSFSKGLGTETAEFAELKTQIEKMRLDYQ 625

Query: 355 ---KDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEGADLLGMGREVE 411
              ++L   + S       E +A       + +E  ++   +   +D+  D        +
Sbjct: 626 HEIENLQNQQDSERAAHAKEMEALRAKLMKVIKEKENSLEAIRSKLDKAED--------Q 677

Query: 412 NLILENTQLLETKNALNIVK--NDLIAKVDELTCEKDVLQGELEAVKQAKLKLE---EKN 466
           +L+     L + + A   VK    L AK +E T   D    +L+A ++  L L+   + +
Sbjct: 678 HLVEMEDTLNKLQEAEIKVKELEVLQAKCNEQTKVIDNFTSQLKATEEKLLDLDALRKAS 737

Query: 467 RELEEELRKARAEAEDARQKAKD-DDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMEL 525
            E + E++K R + E A ++ K  + + +  +++    TR    R L        +L  L
Sbjct: 738 SEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGREL--------KLTNL 789

Query: 526 QEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNTTKKPEPPVNLKYNAPTSHV 585
           QE +     ++ +       EK+   + + F+     + +  +  +  VN          
Sbjct: 790 QENLSEVSQVKET------LEKELQILKEKFAEASEEAVSVQRSMQETVN---------- 833

Query: 586 TPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQA 645
              + ++    + L  D  K    L E      A  RE+   + + +KA  + E+   + 
Sbjct: 834 --KLHQKEEQFNMLSSDLEK----LRENLADMEAKFREKDEREEQLIKAKEKLENDIAEI 887

Query: 646 FGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGS 705
              S          G   +++  +   + L+  D ++  +KL  A   N S  +      
Sbjct: 888 MKMS----------GDNSSQLTKMNDELRLKERDVEELQLKLTKA-NENASFLQKSIEDM 936

Query: 706 VVGASVFYKDVAGLDTEGSKQRSASQSSLDKLDQELKEQQKELKNQEE 753
            V A    ++ A    E  K+     S L+K  +    Q +ELK + E
Sbjct: 937 TVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYE 984


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.310    0.128    0.360 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 51,934,206
Number of Sequences: 37866
Number of extensions: 2529791
Number of successful extensions: 18861
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 276
Number of HSP's successfully gapped in prelim test: 828
Number of HSP's that attempted gapping in prelim test: 11354
Number of HSP's gapped (non-prelim): 6063
length of query: 1321
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1207
effective length of database: 13,930,794
effective search space: 16814468358
effective search space used: 16814468358
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.