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Search of human proteins with 194394237
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194394237 villin 1 [Homo sapiens]
(827 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194394237 villin 1 [Homo sapiens] 1679 0.0
gi|17572824 advillin [Homo sapiens] 1040 0.0
gi|94721268 villin-like protein [Homo sapiens] 789 0.0
gi|4504165 gelsolin isoform a precursor [Homo sapiens] 684 0.0
gi|38044288 gelsolin isoform b [Homo sapiens] 684 0.0
gi|189083782 gelsolin isoform c [Homo sapiens] 684 0.0
gi|189083780 gelsolin isoform c [Homo sapiens] 684 0.0
gi|189083778 gelsolin isoform b [Homo sapiens] 684 0.0
gi|189083776 gelsolin isoform b [Homo sapiens] 684 0.0
gi|189083774 gelsolin isoform b [Homo sapiens] 684 0.0
gi|189083772 gelsolin isoform b [Homo sapiens] 684 0.0
gi|162951877 scinderin isoform 1 [Homo sapiens] 668 0.0
gi|14916473 scinderin isoform 2 [Homo sapiens] 469 e-132
gi|4503743 flightless I homolog [Homo sapiens] 270 4e-72
gi|63252913 gelsolin-like capping protein [Homo sapiens] 259 5e-69
gi|150417973 supervillin isoform 2 [Homo sapiens] 177 5e-44
gi|150417971 supervillin isoform 1 [Homo sapiens] 177 5e-44
gi|166706885 erythrocyte membrane protein band 4.9 isoform 3 [Ho... 64 4e-10
gi|166706883 erythrocyte membrane protein band 4.9 isoform 2 [Ho... 64 4e-10
gi|166706881 erythrocyte membrane protein band 4.9 isoform 2 [Ho... 64 4e-10
gi|166706877 erythrocyte membrane protein band 4.9 isoform 1 [Ho... 62 3e-09
gi|166706879 erythrocyte membrane protein band 4.9 isoform 1 [Ho... 62 3e-09
gi|166706875 erythrocyte membrane protein band 4.9 isoform 1 [Ho... 62 3e-09
gi|7662330 actin binding LIM protein family, member 3 [Homo sapi... 57 9e-08
gi|153792514 actin binding LIM protein family, member 2 isoform ... 52 3e-06
gi|194272204 actin binding LIM protein family, member 2 isoform ... 52 3e-06
gi|194272202 actin binding LIM protein family, member 2 isoform ... 52 3e-06
gi|194272200 actin binding LIM protein family, member 2 isoform ... 52 3e-06
gi|194272198 actin binding LIM protein family, member 2 isoform ... 52 3e-06
gi|194272196 actin binding LIM protein family, member 2 isoform ... 52 3e-06
>gi|194394237 villin 1 [Homo sapiens]
Length = 827
Score = 1679 bits (4349), Expect = 0.0
Identities = 827/827 (100%), Positives = 827/827 (100%)
Query: 1 MTKLSAQVKGSLNITTPGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSY 60
MTKLSAQVKGSLNITTPGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSY
Sbjct: 1 MTKLSAQVKGSLNITTPGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSY 60
Query: 61 DIHYWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKG 120
DIHYWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKG
Sbjct: 61 DIHYWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKG 120
Query: 121 GVASGMKHVETNSYDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGP 180
GVASGMKHVETNSYDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGP
Sbjct: 121 GVASGMKHVETNSYDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGP 180
Query: 181 ESTRMERLRGMTLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAV 240
ESTRMERLRGMTLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAV
Sbjct: 181 ESTRMERLRGMTLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAV 240
Query: 241 PDTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKG 300
PDTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKG
Sbjct: 241 PDTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKG 300
Query: 301 KKANEQEKKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGK 360
KKANEQEKKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGK
Sbjct: 301 KKANEQEKKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGK 360
Query: 361 THTVGSVAKVEQVKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGH 420
THTVGSVAKVEQVKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGH
Sbjct: 361 THTVGSVAKVEQVKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGH 420
Query: 421 FYGGDCYLLLYTYLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVP 480
FYGGDCYLLLYTYLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVP
Sbjct: 421 FYGGDCYLLLYTYLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVP 480
Query: 481 MGKEPPHLMSIFKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFL 540
MGKEPPHLMSIFKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFL
Sbjct: 481 MGKEPPHLMSIFKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFL 540
Query: 541 NSNDVFVLKTQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGG 600
NSNDVFVLKTQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGG
Sbjct: 541 NSNDVFVLKTQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGG 600
Query: 601 KAPYANTKRLQEENLVITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFF 660
KAPYANTKRLQEENLVITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFF
Sbjct: 601 KAPYANTKRLQEENLVITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFF 660
Query: 661 WIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
WIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS
Sbjct: 661 WIGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
Query: 721 NTKSYEDLKAELGNSRDWSQITAEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEEL 780
NTKSYEDLKAELGNSRDWSQITAEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEEL
Sbjct: 721 NTKSYEDLKAELGNSRDWSQITAEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEEL 780
Query: 781 PEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEKGLF 827
PEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEKGLF
Sbjct: 781 PEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKEKGLF 827
>gi|17572824 advillin [Homo sapiens]
Length = 819
Score = 1040 bits (2690), Expect = 0.0
Identities = 500/811 (61%), Positives = 620/811 (76%), Gaps = 5/811 (0%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSYDIHYWIGQDSSLDEQG 76
PG+ +WRIE M++ VP S G+F++GDCY+IL+ + AS LS DIH+WIG+DSS DEQ
Sbjct: 14 PGIIVWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHFWIGKDSSQDEQS 73
Query: 77 AAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYDV 136
AAIYTTQ+DD+L G VQHREVQ +ES+ FRGYFKQG++ ++GGVASGMKHVETN+YDV
Sbjct: 74 CAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVASGMKHVETNTYDV 133
Query: 137 QRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAKE 196
+RLLHVKGKRN+ A EVEMSW SFNRGDVFLLDLGK+IIQWNGPES ERL+ M LAK+
Sbjct: 134 KRLLHVKGKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGERLKAMLLAKD 193
Query: 197 IRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAALKLY 256
IRD+ERGGR +GV++G+ E ASP+LM+V+ LG+R +K VPD +++ K+ + LY
Sbjct: 194 IRDRERGGRAEIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQKQKSTIMLY 253
Query: 257 HVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKGKKANEQEKKGAMSHAL 316
H+SDS G L V EVATRPL QDLL+H+DCYILDQ G KIYVWKGK A + EK+ AMS AL
Sbjct: 254 HISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAEKQAAMSKAL 313
Query: 317 NFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQVKFD 376
FIK K YP ST VE NDGAESA+F+QLFQKW+ ++T GLGKT ++G +AKV Q KFD
Sbjct: 314 GFIKMKSYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTMGLGKTFSIGKIAKVFQDKFD 373
Query: 377 ATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYTYLIG 436
T +H KP+VAAQ++MVDDG+G+V+VWRIENLELVPV+ +W G FYGGDCYL+LYTY +
Sbjct: 374 VTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWYGFFYGGDCYLVLYTYEVN 433
Query: 437 EKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFKGRM 496
K H++LY+WQG ASQDE+ ASAYQAV +D++++G VQ+RV MG EP H M+IFKG++
Sbjct: 434 GKPHHILYIWQGRHASQDELAASAYQAVEVDRQFDGAAVQVRVRMGTEPRHFMAIFKGKL 493
Query: 497 VVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQSCCYL 556
V+++GGTSR N E P RLFQ+ G +NTKA EVPA A+ LNSNDVF+L+TQ+ YL
Sbjct: 494 VIFEGGTSRKGNAEPDPPVRLFQIHGNDKSNTKAVEVPAFASSLNSNDVFLLRTQAEHYL 553
Query: 557 WCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQEENLV 616
W GKG SGDER MAK +A + + V EGQEPA FW LGGK PYAN KRLQ+E L
Sbjct: 554 WYGKGSSGDERAMAKELASLLCDGSENTVAEGQEPAEFWDLLGGKTPYANDKRLQQEILD 613
Query: 617 ITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFFWIGKHANEEEKKAAAT 676
+ RLFECSNKTG+F+ TEI DF QDDL DV LLD WDQVF WIG AN EK++A
Sbjct: 614 VQSRLFECSNKTGQFVVTEITDFTQDDLNPTDVMLLDTWDQVFLWIGAEANATEKESALA 673
Query: 677 TAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYEDLKAELGNSR 736
TAQ+YL THPSGRDP+TPI+++KQG EPP FTGWFLAWDP WS K+YE LK ELG++
Sbjct: 674 TAQQYLHTHPSGRDPDTPILIIKQGFEPPIFTGWFLAWDPNIWSAGKTYEQLKEELGDAA 733
Query: 737 DWSQITAEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIE 796
+ITA++ K + NSN S +P+ L+ +ELPE V+P++KE +LS +
Sbjct: 734 AIMRITADM---KNATLSLNSNDSEP--KYYPIAVLLKNQNQELPEDVNPAKKENYLSEQ 788
Query: 797 DFTQAFGMTPAAFSALPRWKQQNLKKEKGLF 827
DF FG+T F+ALP WKQ +KKEKGLF
Sbjct: 789 DFVSVFGITRGQFAALPGWKQLQMKKEKGLF 819
Score = 119 bits (297), Expect = 1e-26
Identities = 119/420 (28%), Positives = 179/420 (42%), Gaps = 48/420 (11%)
Query: 391 KMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYTYLIGEKQHYLLYVWQGSQ 450
+ VD+ G + VWRIE +EL V G+FY GDCY++L T + ++ W G
Sbjct: 8 RAVDNDPGII-VWRIEKMELALVPVSAHGNFYEGDCYVILSTRRVASLLSQDIHFWIGKD 66
Query: 451 ASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFKGRMVVYQGG-TSRTNNL 509
+SQDE + +A LD G PVQ R E FK ++ QGG S ++
Sbjct: 67 SSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKQGIIYKQGGVASGMKHV 126
Query: 510 ETG--PSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGCSGDER 567
ET RL V+ G N +A EV + N DVF+L W G + ER
Sbjct: 127 ETNTYDVKRLLHVK--GKRNIRATEVEMSWDSFNRGDVFLLDLGKVIIQWNGPESNSGER 184
Query: 568 EMAKMVADTISRTEKQ-----VVVEGQEPAN-------FWMALGGKAPYANT--KRLQEE 613
A ++A I E+ V+EG + A LG ++ T + ++
Sbjct: 185 LKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPELMKVLQDTLGRRSIIKPTVPDEIIDQ 244
Query: 614 NLVITPRLFECSNKTGRFLATEIP--DFNQDDLEEDDVFLLD-VWDQVFFWIGKHANEEE 670
T L+ S+ G+ TE+ QD L DD ++LD +++ W GK A + E
Sbjct: 245 KQKSTIMLYHISDSAGQLAVTEVATRPLVQDLLNHDDCYILDQSGTKIYVWKGKGATKAE 304
Query: 671 KKAAATTAQEY--LKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYEDL 728
K+AA + A + +K++PS + ET V G E F F W S +D
Sbjct: 305 KQAAMSKALGFIKMKSYPSSTNVET----VNDGAESAMFKQLFQKW---------SVKDQ 351
Query: 729 KAELGNS----------RDWSQITAEVTSPKVDVFNANSNLSSGPLPIFPLEQLVNKPVE 778
LG + +D +T T P+V + +G + ++ +E L PVE
Sbjct: 352 TMGLGKTFSIGKIAKVFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVE 411
>gi|94721268 villin-like protein [Homo sapiens]
Length = 856
Score = 789 bits (2037), Expect = 0.0
Identities = 408/853 (47%), Positives = 558/853 (65%), Gaps = 52/853 (6%)
Query: 18 GLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIH---KTASSLSYDIHYWIGQDSSLDE 74
GL IW E +MVPVP +G+FF+ CY+IL + K S D+HYW+G+ + +
Sbjct: 13 GLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHYWVGKQAGAEA 72
Query: 75 QGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSY 134
QGAA + ++ D L G+ V HRE QG+ES+ F YF+ G++ RKGG+AS +KHVETN +
Sbjct: 73 QGAAEAFQQRLQDELGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKHVETNLF 132
Query: 135 DVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLA 194
++QRLLH+KG+++V A EVE+SW SFN+GD+FLLDLGK++IQWNGP+++ E+ RG+ L
Sbjct: 133 NIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSISEKARGLALT 192
Query: 195 KEIRDQERGG-RTYVGVVDGENELASPKLMEVMNHVLGKR-RELKAAVPDTVVEPALKAA 252
+RD+ERGG R +GVVD +E +P LM++M VLG+R L+AA P + KA
Sbjct: 193 YSLRDRERGGGRAQIGVVD--DEAKAPDLMQIMEAVLGRRVGSLRAATPSKDINQLQKAN 250
Query: 253 LKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGLKIYVWKGKKANEQEKKGAM 312
++LYHV + +LVV E+AT PLTQDLL ED YILDQGG KIYVW+G+ ++ QE+K A
Sbjct: 251 VRLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVWQGRMSSLQERKAAF 310
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
S A+ FI+AK YP T VEV NDGAESA F+QLF+ W+ R + +G K
Sbjct: 311 SRAVGFIQAKGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRR-----RNQKLGGRDKSIH 365
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
VK D +H +P++AAQ +MVDDGSG+V+VW I++L PVD K G G+CYL+LYT
Sbjct: 366 VKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPVDPKRHGQLCAGNCYLVLYT 425
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y + Y+LY+WQG QA+ DEI A A LD Y G VQ V MG EPPH ++IF
Sbjct: 426 YQRLGRVQYILYLWQGHQATADEIEALNSNAEELDVMYGGVLVQEHVTMGSEPPHFLAIF 485
Query: 493 KGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQS 552
+G++V++Q ++ +TRLFQVQGT ++NT+ EVPARA+ LNS+D+F+L T S
Sbjct: 486 QGQLVIFQERAGHHGKGQSASTTRLFQVQGTDSHNTRTMEVPARASSLNSSDIFLLVTAS 545
Query: 553 CCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQE 612
CYLW GKGC+GD+REMA++V ISR ++ V+EGQEP +FW ALGG+APY + KRL E
Sbjct: 546 VCYLWFGKGCNGDQREMARVVVTVISRKNEETVLEGQEPPHFWEALGGRAPYPSNKRLPE 605
Query: 613 ENLVITPRLFECSNKTGRFLATEIPDFNQDDLEEDDVFLLDVWDQVFFWIGKHANEEEKK 672
E PRLFECS+ G + E+ F+Q+DL++ D+ LLD W ++F W+G+ A+E K
Sbjct: 606 EVPSFQPRLFECSSHMGCLVLAEVGFFSQEDLDKYDIMLLDTWQEIFLWLGEAASEW--K 663
Query: 673 AAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYED----- 727
A QEYLKTHP+GR P TPI++VKQGHEPPTF GWF WDP+KW++ S+++
Sbjct: 664 EAVAWGQEYLKTHPAGRSPATPIVLVKQGHEPPTFIGWFFTWDPYKWTSHPSHKEVVDGS 723
Query: 728 ---------LKAELGNSR--DW----------------SQITAE---VTSPKVDVFNANS 757
+ AE+ N R W SQ ++E V SPK +S
Sbjct: 724 PAAASTISEITAEVNNLRLSRWPGNGRAGAVALQALKGSQDSSENDLVRSPKSAGSRTSS 783
Query: 758 NLSSGPLPI---FPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPR 814
++SS I EQL+++ VE+LPEGVDP+R+E +LS DF FG + F ++
Sbjct: 784 SVSSTSATINGGLRREQLMHQAVEDLPEGVDPARREFYLSDSDFQDIFGKSKEEFYSMAT 843
Query: 815 WKQQNLKKEKGLF 827
W+Q+ KK+ G F
Sbjct: 844 WRQRQEKKQLGFF 856
Score = 88.2 bits (217), Expect = 3e-17
Identities = 106/426 (24%), Positives = 177/426 (41%), Gaps = 65/426 (15%)
Query: 398 GEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLY-------TYLIGEKQHYLLYVWQGSQ 450
G + +W EN ++VPV G+F+ CY++L+ T HY W G Q
Sbjct: 12 GGLHIWISENRKMVPVPEGAYGNFFEEHCYVILHVPQSPKATQGASSDLHY----WVGKQ 67
Query: 451 A-SQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFKGRMVVYQGG-TSRTNN 508
A ++ + A A+Q + D+ G+ V R G E S F+ ++ +GG S +
Sbjct: 68 AGAEAQGAAEAFQQRLQDE-LGGQTVLHREAQGHESDCFCSYFRPGIIYRKGGLASDLKH 126
Query: 509 LETGPSTRLFQVQG----TGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGCSG 564
+E T LF +Q G + A EV N N D+F+L W G S
Sbjct: 127 VE----TNLFNIQRLLHIKGRKHVSATEVELSWNSFNKGDIFLLDLGKMMIQWNGPKTSI 182
Query: 565 DEREMAKMVADTISRTEKQ--------VVVEGQEPANFWM------------ALGGKAPY 604
E+ A+ +A T S +++ VV+ + A M +L P
Sbjct: 183 SEK--ARGLALTYSLRDRERGGGRAQIGVVDDEAKAPDLMQIMEAVLGRRVGSLRAATPS 240
Query: 605 ANTKRLQEENLVITPRLFECSNKTGRFLATEI--PDFNQDDLEEDDVFLLDVWD-QVFFW 661
+ +LQ+ N+ RL+ K + E+ P QD L+E+D ++LD +++ W
Sbjct: 241 KDINQLQKANV----RLYHVYEKGKDLVVLELATPPLTQDLLQEEDFYILDQGGFKIYVW 296
Query: 662 IGKHANEEEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSN 721
G+ ++ +E+KAA + A +++ G T + VV G E F F W + N
Sbjct: 297 QGRMSSLQERKAAFSRAVGFIQA--KGYPTYTNVEVVNDGAESAAFKQLFRTWSEKRRRN 354
Query: 722 TKSYEDLKAELGNSRDWSQITAEV----TSPKVDVFNANSNLSSGPLPIFPLEQLVNKPV 777
K LG + +V T PK+ + SG + ++ ++ L +PV
Sbjct: 355 QK--------LGGRDKSIHVKLDVGKLHTQPKLAAQLRMVDDGSGKVEVWCIQDLHRQPV 406
Query: 778 EELPEG 783
+ G
Sbjct: 407 DPKRHG 412
>gi|4504165 gelsolin isoform a precursor [Homo sapiens]
Length = 782
Score = 684 bits (1765), Expect = 0.0
Identities = 361/711 (50%), Positives = 452/711 (63%), Gaps = 14/711 (1%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIIL-AIHKTASSLSYDIHYWIGQDSSLDEQ 75
PGLQIWR+E +VPVP++ +G FF GD Y+IL + +L YD+HYW+G + S DE
Sbjct: 66 PGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDES 125
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
GAAAI+T Q+DD+L GRAVQHREVQG ES F GYFK GL +KGGVASG KHV N
Sbjct: 126 GAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVV 185
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
VQRL VKG+R V A EV +SW+SFN GD F+LDLG I QW G S R ERL+ ++K
Sbjct: 186 VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSK 245
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAAL-K 254
IRD ER GR V V + E E M VLG + L A DT E A L K
Sbjct: 246 GIRDNERSGRARVHVSEEGTE------PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAK 299
Query: 255 LYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQG-GLKIYVWKGKKANEQEKKGAM 312
LY VS+ G + V VA P Q L EDC+ILD G KI+VWKGK+AN +E+K A+
Sbjct: 300 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 359
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
A +FI YP TQV V +G E+ +F+Q F+ W ++T GLG ++ +A VE+
Sbjct: 360 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVER 419
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
V FDA ++H +AAQ M DDG+G+ Q+WRIE VPVD G FYGGD Y++LY
Sbjct: 420 VPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYN 479
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y G +Q ++Y WQG+Q++QDE+ ASA LD++ G PVQ RV GKEP HLMS+F
Sbjct: 480 YRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLF 539
Query: 493 KGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQ 551
G+ M++Y+GGTSR STRLFQV+ A T+A EV +A LNSND FVLKT
Sbjct: 540 GGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTP 599
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
S YLW G G S E+ A+ + + R + V EG EP FW ALGGKA Y + RL+
Sbjct: 600 SAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLK 658
Query: 612 EENL-VITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEE 669
++ + PRLF CSNK GRF+ E+P + Q+DL DDV LLD WDQVF W+GK + EE
Sbjct: 659 DKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEE 718
Query: 670 EKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
EK A T+A+ Y++T P+ RD TPI VVKQG EPP+F GWFL WD WS
Sbjct: 719 EKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWS 769
>gi|38044288 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 684 bits (1765), Expect = 0.0
Identities = 361/711 (50%), Positives = 452/711 (63%), Gaps = 14/711 (1%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIIL-AIHKTASSLSYDIHYWIGQDSSLDEQ 75
PGLQIWR+E +VPVP++ +G FF GD Y+IL + +L YD+HYW+G + S DE
Sbjct: 15 PGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDES 74
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
GAAAI+T Q+DD+L GRAVQHREVQG ES F GYFK GL +KGGVASG KHV N
Sbjct: 75 GAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVV 134
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
VQRL VKG+R V A EV +SW+SFN GD F+LDLG I QW G S R ERL+ ++K
Sbjct: 135 VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSK 194
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAAL-K 254
IRD ER GR V V + E E M VLG + L A DT E A L K
Sbjct: 195 GIRDNERSGRARVHVSEEGTE------PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAK 248
Query: 255 LYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQG-GLKIYVWKGKKANEQEKKGAM 312
LY VS+ G + V VA P Q L EDC+ILD G KI+VWKGK+AN +E+K A+
Sbjct: 249 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 308
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
A +FI YP TQV V +G E+ +F+Q F+ W ++T GLG ++ +A VE+
Sbjct: 309 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVER 368
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
V FDA ++H +AAQ M DDG+G+ Q+WRIE VPVD G FYGGD Y++LY
Sbjct: 369 VPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYN 428
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y G +Q ++Y WQG+Q++QDE+ ASA LD++ G PVQ RV GKEP HLMS+F
Sbjct: 429 YRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLF 488
Query: 493 KGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQ 551
G+ M++Y+GGTSR STRLFQV+ A T+A EV +A LNSND FVLKT
Sbjct: 489 GGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTP 548
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
S YLW G G S E+ A+ + + R + V EG EP FW ALGGKA Y + RL+
Sbjct: 549 SAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLK 607
Query: 612 EENL-VITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEE 669
++ + PRLF CSNK GRF+ E+P + Q+DL DDV LLD WDQVF W+GK + EE
Sbjct: 608 DKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEE 667
Query: 670 EKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
EK A T+A+ Y++T P+ RD TPI VVKQG EPP+F GWFL WD WS
Sbjct: 668 EKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWS 718
>gi|189083782 gelsolin isoform c [Homo sapiens]
Length = 742
Score = 684 bits (1765), Expect = 0.0
Identities = 361/711 (50%), Positives = 452/711 (63%), Gaps = 14/711 (1%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIIL-AIHKTASSLSYDIHYWIGQDSSLDEQ 75
PGLQIWR+E +VPVP++ +G FF GD Y+IL + +L YD+HYW+G + S DE
Sbjct: 26 PGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDES 85
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
GAAAI+T Q+DD+L GRAVQHREVQG ES F GYFK GL +KGGVASG KHV N
Sbjct: 86 GAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVV 145
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
VQRL VKG+R V A EV +SW+SFN GD F+LDLG I QW G S R ERL+ ++K
Sbjct: 146 VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSK 205
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAAL-K 254
IRD ER GR V V + E E M VLG + L A DT E A L K
Sbjct: 206 GIRDNERSGRARVHVSEEGTE------PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAK 259
Query: 255 LYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQG-GLKIYVWKGKKANEQEKKGAM 312
LY VS+ G + V VA P Q L EDC+ILD G KI+VWKGK+AN +E+K A+
Sbjct: 260 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 319
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
A +FI YP TQV V +G E+ +F+Q F+ W ++T GLG ++ +A VE+
Sbjct: 320 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVER 379
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
V FDA ++H +AAQ M DDG+G+ Q+WRIE VPVD G FYGGD Y++LY
Sbjct: 380 VPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYN 439
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y G +Q ++Y WQG+Q++QDE+ ASA LD++ G PVQ RV GKEP HLMS+F
Sbjct: 440 YRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLF 499
Query: 493 KGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQ 551
G+ M++Y+GGTSR STRLFQV+ A T+A EV +A LNSND FVLKT
Sbjct: 500 GGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTP 559
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
S YLW G G S E+ A+ + + R + V EG EP FW ALGGKA Y + RL+
Sbjct: 560 SAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLK 618
Query: 612 EENL-VITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEE 669
++ + PRLF CSNK GRF+ E+P + Q+DL DDV LLD WDQVF W+GK + EE
Sbjct: 619 DKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEE 678
Query: 670 EKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
EK A T+A+ Y++T P+ RD TPI VVKQG EPP+F GWFL WD WS
Sbjct: 679 EKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWS 729
>gi|189083780 gelsolin isoform c [Homo sapiens]
Length = 742
Score = 684 bits (1765), Expect = 0.0
Identities = 361/711 (50%), Positives = 452/711 (63%), Gaps = 14/711 (1%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIIL-AIHKTASSLSYDIHYWIGQDSSLDEQ 75
PGLQIWR+E +VPVP++ +G FF GD Y+IL + +L YD+HYW+G + S DE
Sbjct: 26 PGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDES 85
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
GAAAI+T Q+DD+L GRAVQHREVQG ES F GYFK GL +KGGVASG KHV N
Sbjct: 86 GAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVV 145
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
VQRL VKG+R V A EV +SW+SFN GD F+LDLG I QW G S R ERL+ ++K
Sbjct: 146 VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSK 205
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAAL-K 254
IRD ER GR V V + E E M VLG + L A DT E A L K
Sbjct: 206 GIRDNERSGRARVHVSEEGTE------PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAK 259
Query: 255 LYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQG-GLKIYVWKGKKANEQEKKGAM 312
LY VS+ G + V VA P Q L EDC+ILD G KI+VWKGK+AN +E+K A+
Sbjct: 260 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 319
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
A +FI YP TQV V +G E+ +F+Q F+ W ++T GLG ++ +A VE+
Sbjct: 320 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVER 379
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
V FDA ++H +AAQ M DDG+G+ Q+WRIE VPVD G FYGGD Y++LY
Sbjct: 380 VPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYN 439
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y G +Q ++Y WQG+Q++QDE+ ASA LD++ G PVQ RV GKEP HLMS+F
Sbjct: 440 YRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLF 499
Query: 493 KGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQ 551
G+ M++Y+GGTSR STRLFQV+ A T+A EV +A LNSND FVLKT
Sbjct: 500 GGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTP 559
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
S YLW G G S E+ A+ + + R + V EG EP FW ALGGKA Y + RL+
Sbjct: 560 SAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLK 618
Query: 612 EENL-VITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEE 669
++ + PRLF CSNK GRF+ E+P + Q+DL DDV LLD WDQVF W+GK + EE
Sbjct: 619 DKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEE 678
Query: 670 EKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
EK A T+A+ Y++T P+ RD TPI VVKQG EPP+F GWFL WD WS
Sbjct: 679 EKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWS 729
>gi|189083778 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 684 bits (1765), Expect = 0.0
Identities = 361/711 (50%), Positives = 452/711 (63%), Gaps = 14/711 (1%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIIL-AIHKTASSLSYDIHYWIGQDSSLDEQ 75
PGLQIWR+E +VPVP++ +G FF GD Y+IL + +L YD+HYW+G + S DE
Sbjct: 15 PGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDES 74
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
GAAAI+T Q+DD+L GRAVQHREVQG ES F GYFK GL +KGGVASG KHV N
Sbjct: 75 GAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVV 134
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
VQRL VKG+R V A EV +SW+SFN GD F+LDLG I QW G S R ERL+ ++K
Sbjct: 135 VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSK 194
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAAL-K 254
IRD ER GR V V + E E M VLG + L A DT E A L K
Sbjct: 195 GIRDNERSGRARVHVSEEGTE------PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAK 248
Query: 255 LYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQG-GLKIYVWKGKKANEQEKKGAM 312
LY VS+ G + V VA P Q L EDC+ILD G KI+VWKGK+AN +E+K A+
Sbjct: 249 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 308
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
A +FI YP TQV V +G E+ +F+Q F+ W ++T GLG ++ +A VE+
Sbjct: 309 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVER 368
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
V FDA ++H +AAQ M DDG+G+ Q+WRIE VPVD G FYGGD Y++LY
Sbjct: 369 VPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYN 428
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y G +Q ++Y WQG+Q++QDE+ ASA LD++ G PVQ RV GKEP HLMS+F
Sbjct: 429 YRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLF 488
Query: 493 KGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQ 551
G+ M++Y+GGTSR STRLFQV+ A T+A EV +A LNSND FVLKT
Sbjct: 489 GGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTP 548
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
S YLW G G S E+ A+ + + R + V EG EP FW ALGGKA Y + RL+
Sbjct: 549 SAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLK 607
Query: 612 EENL-VITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEE 669
++ + PRLF CSNK GRF+ E+P + Q+DL DDV LLD WDQVF W+GK + EE
Sbjct: 608 DKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEE 667
Query: 670 EKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
EK A T+A+ Y++T P+ RD TPI VVKQG EPP+F GWFL WD WS
Sbjct: 668 EKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWS 718
>gi|189083776 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 684 bits (1765), Expect = 0.0
Identities = 361/711 (50%), Positives = 452/711 (63%), Gaps = 14/711 (1%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIIL-AIHKTASSLSYDIHYWIGQDSSLDEQ 75
PGLQIWR+E +VPVP++ +G FF GD Y+IL + +L YD+HYW+G + S DE
Sbjct: 15 PGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDES 74
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
GAAAI+T Q+DD+L GRAVQHREVQG ES F GYFK GL +KGGVASG KHV N
Sbjct: 75 GAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVV 134
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
VQRL VKG+R V A EV +SW+SFN GD F+LDLG I QW G S R ERL+ ++K
Sbjct: 135 VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSK 194
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAAL-K 254
IRD ER GR V V + E E M VLG + L A DT E A L K
Sbjct: 195 GIRDNERSGRARVHVSEEGTE------PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAK 248
Query: 255 LYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQG-GLKIYVWKGKKANEQEKKGAM 312
LY VS+ G + V VA P Q L EDC+ILD G KI+VWKGK+AN +E+K A+
Sbjct: 249 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 308
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
A +FI YP TQV V +G E+ +F+Q F+ W ++T GLG ++ +A VE+
Sbjct: 309 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVER 368
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
V FDA ++H +AAQ M DDG+G+ Q+WRIE VPVD G FYGGD Y++LY
Sbjct: 369 VPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYN 428
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y G +Q ++Y WQG+Q++QDE+ ASA LD++ G PVQ RV GKEP HLMS+F
Sbjct: 429 YRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLF 488
Query: 493 KGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQ 551
G+ M++Y+GGTSR STRLFQV+ A T+A EV +A LNSND FVLKT
Sbjct: 489 GGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTP 548
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
S YLW G G S E+ A+ + + R + V EG EP FW ALGGKA Y + RL+
Sbjct: 549 SAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLK 607
Query: 612 EENL-VITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEE 669
++ + PRLF CSNK GRF+ E+P + Q+DL DDV LLD WDQVF W+GK + EE
Sbjct: 608 DKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEE 667
Query: 670 EKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
EK A T+A+ Y++T P+ RD TPI VVKQG EPP+F GWFL WD WS
Sbjct: 668 EKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWS 718
>gi|189083774 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 684 bits (1765), Expect = 0.0
Identities = 361/711 (50%), Positives = 452/711 (63%), Gaps = 14/711 (1%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIIL-AIHKTASSLSYDIHYWIGQDSSLDEQ 75
PGLQIWR+E +VPVP++ +G FF GD Y+IL + +L YD+HYW+G + S DE
Sbjct: 15 PGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDES 74
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
GAAAI+T Q+DD+L GRAVQHREVQG ES F GYFK GL +KGGVASG KHV N
Sbjct: 75 GAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVV 134
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
VQRL VKG+R V A EV +SW+SFN GD F+LDLG I QW G S R ERL+ ++K
Sbjct: 135 VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSK 194
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAAL-K 254
IRD ER GR V V + E E M VLG + L A DT E A L K
Sbjct: 195 GIRDNERSGRARVHVSEEGTE------PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAK 248
Query: 255 LYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQG-GLKIYVWKGKKANEQEKKGAM 312
LY VS+ G + V VA P Q L EDC+ILD G KI+VWKGK+AN +E+K A+
Sbjct: 249 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 308
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
A +FI YP TQV V +G E+ +F+Q F+ W ++T GLG ++ +A VE+
Sbjct: 309 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVER 368
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
V FDA ++H +AAQ M DDG+G+ Q+WRIE VPVD G FYGGD Y++LY
Sbjct: 369 VPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYN 428
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y G +Q ++Y WQG+Q++QDE+ ASA LD++ G PVQ RV GKEP HLMS+F
Sbjct: 429 YRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLF 488
Query: 493 KGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQ 551
G+ M++Y+GGTSR STRLFQV+ A T+A EV +A LNSND FVLKT
Sbjct: 489 GGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTP 548
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
S YLW G G S E+ A+ + + R + V EG EP FW ALGGKA Y + RL+
Sbjct: 549 SAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLK 607
Query: 612 EENL-VITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEE 669
++ + PRLF CSNK GRF+ E+P + Q+DL DDV LLD WDQVF W+GK + EE
Sbjct: 608 DKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEE 667
Query: 670 EKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
EK A T+A+ Y++T P+ RD TPI VVKQG EPP+F GWFL WD WS
Sbjct: 668 EKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWS 718
>gi|189083772 gelsolin isoform b [Homo sapiens]
Length = 731
Score = 684 bits (1765), Expect = 0.0
Identities = 361/711 (50%), Positives = 452/711 (63%), Gaps = 14/711 (1%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIIL-AIHKTASSLSYDIHYWIGQDSSLDEQ 75
PGLQIWR+E +VPVP++ +G FF GD Y+IL + +L YD+HYW+G + S DE
Sbjct: 15 PGLQIWRVEKFDLVPVPTNLYGDFFTGDAYVILKTVQLRNGNLQYDLHYWLGNECSQDES 74
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
GAAAI+T Q+DD+L GRAVQHREVQG ES F GYFK GL +KGGVASG KHV N
Sbjct: 75 GAAAIFTVQLDDYLNGRAVQHREVQGFESATFLGYFKSGLKYKKGGVASGFKHVVPNEVV 134
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
VQRL VKG+R V A EV +SW+SFN GD F+LDLG I QW G S R ERL+ ++K
Sbjct: 135 VQRLFQVKGRRVVRATEVPVSWESFNNGDCFILDLGNNIHQWCGSNSNRYERLKATQVSK 194
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAAL-K 254
IRD ER GR V V + E E M VLG + L A DT E A L K
Sbjct: 195 GIRDNERSGRARVHVSEEGTE------PEAMLQVLGPKPALPAGTEDTAKEDAANRKLAK 248
Query: 255 LYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQG-GLKIYVWKGKKANEQEKKGAM 312
LY VS+ G + V VA P Q L EDC+ILD G KI+VWKGK+AN +E+K A+
Sbjct: 249 LYKVSNGAGTMSVSLVADENPFAQGALKSEDCFILDHGKDGKIFVWKGKQANTEERKAAL 308
Query: 313 SHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQ 372
A +FI YP TQV V +G E+ +F+Q F+ W ++T GLG ++ +A VE+
Sbjct: 309 KTASDFITKMDYPKQTQVSVLPEGGETPLFKQFFKNWRDPDQTDGLGLSYLSSHIANVER 368
Query: 373 VKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYT 432
V FDA ++H +AAQ M DDG+G+ Q+WRIE VPVD G FYGGD Y++LY
Sbjct: 369 VPFDAATLHTSTAMAAQHGMDDDGTGQKQIWRIEGSNKVPVDPATYGQFYGGDSYIILYN 428
Query: 433 YLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIF 492
Y G +Q ++Y WQG+Q++QDE+ ASA LD++ G PVQ RV GKEP HLMS+F
Sbjct: 429 YRHGGRQGQIIYNWQGAQSTQDEVAASAILTAQLDEELGGTPVQSRVVQGKEPAHLMSLF 488
Query: 493 KGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQ 551
G+ M++Y+GGTSR STRLFQV+ A T+A EV +A LNSND FVLKT
Sbjct: 489 GGKPMIIYKGGTSREGGQTAPASTRLFQVRANSAGATRAVEVLPKAGALNSNDAFVLKTP 548
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
S YLW G G S E+ A+ + + R + V EG EP FW ALGGKA Y + RL+
Sbjct: 549 SAAYLWVGTGASEAEKTGAQELL-RVLRAQPVQVAEGSEPDGFWEALGGKAAYRTSPRLK 607
Query: 612 EENL-VITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEE 669
++ + PRLF CSNK GRF+ E+P + Q+DL DDV LLD WDQVF W+GK + EE
Sbjct: 608 DKKMDAHPPRLFACSNKIGRFVIEEVPGELMQEDLATDDVMLLDTWDQVFVWVGKDSQEE 667
Query: 670 EKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKWS 720
EK A T+A+ Y++T P+ RD TPI VVKQG EPP+F GWFL WD WS
Sbjct: 668 EKTEALTSAKRYIETDPANRDRRTPITVVKQGFEPPSFVGWFLGWDDDYWS 718
>gi|162951877 scinderin isoform 1 [Homo sapiens]
Length = 715
Score = 668 bits (1724), Expect = 0.0
Identities = 341/709 (48%), Positives = 468/709 (66%), Gaps = 18/709 (2%)
Query: 18 GLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSYDIHYWIGQDSSLDEQGA 77
GLQ+WRIE +++VPVP S G F+ GD Y++L KT+ +Y +H+W+G++ S DE A
Sbjct: 18 GLQVWRIEKLELVPVPQSAHGDFYVGDAYLVLHTAKTSRGFTYHLHFWLGKECSQDESTA 77
Query: 78 AAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYDVQ 137
AAI+T QMDD+L G+ VQ+RE+QG ES F YFK GL + GGVASG+ HV TN +
Sbjct: 78 AAIFTVQMDDYLGGKPVQNRELQGYESNDFVSYFKGGLKYKAGGVASGLNHVLTNDLTAK 137
Query: 138 RLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAKEI 197
RLLHVKG+R V A EV +SW SFN+GD F++DLG I QW G + ERL+ +A I
Sbjct: 138 RLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGSSCNKYERLKANQVATGI 197
Query: 198 RDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELK--AAVPDTVVEPALKAALKL 255
R ER GR+ + VV+ +E + + VLG++ EL D + + + + KL
Sbjct: 198 RYNERKGRSELIVVEEGSEPSE------LIKVLGEKPELPDGGDDDDIIADISNRKMAKL 251
Query: 256 YHVSDSEGNLVVREVA-TRPLTQDLLSHEDCYILDQGGLK-IYVWKGKKANEQEKKGAMS 313
Y VSD+ G++ V VA P + +L E+C+ILD G K I+VWKGK AN QE+K AM
Sbjct: 252 YMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAAMK 311
Query: 314 HALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVEQV 373
A F++ Y +TQ++V +G E+ +F+Q F+ W +++ G GK + VA+++Q+
Sbjct: 312 TAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIKQI 371
Query: 374 KFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYTY 433
FDA+ +H PQ+AAQ MVDDGSG+V++WR+EN + VD G FYGGDCY++LYTY
Sbjct: 372 PFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTY 431
Query: 434 LIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFK 493
G+ ++Y WQG+ A++DE+T SA+ V LD+ G+ VQIRV GKEP HL+S+FK
Sbjct: 432 PRGQ----IIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFK 487
Query: 494 GR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLK-TQ 551
+ +++Y+ GTS+ P TRLFQV+ A+ T+ EV AN LNSNDVFVLK Q
Sbjct: 488 DKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKLPQ 547
Query: 552 SCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKRLQ 611
+ Y+W GKG S +E + A+ VA ++ + + + EG+EP FW +LGGK Y + L+
Sbjct: 548 NSGYIWVGKGASQEEEKGAEYVA-SVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPLLE 606
Query: 612 EENLVITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANEEE 670
+ PRL+ CSNKTGRF+ EIP +F QDDL EDDV LLD W+Q+F WIGK ANE E
Sbjct: 607 TQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANEVE 666
Query: 671 KKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKW 719
KK + +A+ YL+T PSGRD TPI+++KQGHEPPTFTGWFL WD KW
Sbjct: 667 KKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 715
>gi|14916473 scinderin isoform 2 [Homo sapiens]
Length = 468
Score = 469 bits (1207), Expect = e-132
Identities = 233/471 (49%), Positives = 318/471 (67%), Gaps = 10/471 (2%)
Query: 254 KLYHVSDSEGNLVVREVATR-PLTQDLLSHEDCYILDQGGLK-IYVWKGKKANEQEKKGA 311
KLY VSD+ G++ V VA P + +L E+C+ILD G K I+VWKGK AN QE+K A
Sbjct: 3 KLYMVSDASGSMRVTVVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKDANPQERKAA 62
Query: 312 MSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWTASNRTSGLGKTHTVGSVAKVE 371
M A F++ Y +TQ++V +G E+ +F+Q F+ W +++ G GK + VA+++
Sbjct: 63 MKTAEEFLQQMNYSKNTQIQVLPEGGETPIFKQFFKDWRDKDQSDGFGKVYVTEKVAQIK 122
Query: 372 QVKFDATSMHVKPQVAAQQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLY 431
Q+ FDA+ +H PQ+AAQ MVDDGSG+V++WR+EN + VD G FYGGDCY++LY
Sbjct: 123 QIPFDASKLHSSPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILY 182
Query: 432 TYLIGEKQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSI 491
TY G+ ++Y WQG+ A++DE+T SA+ V LD+ G+ VQIRV GKEP HL+S+
Sbjct: 183 TYPRGQ----IIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSL 238
Query: 492 FKGR-MVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLK- 549
FK + +++Y+ GTS+ P TRLFQV+ A+ T+ EV AN LNSNDVFVLK
Sbjct: 239 FKDKPLIIYKNGTSKKGGQAPAPPTRLFQVRRNLASITRIVEVDVDANSLNSNDVFVLKL 298
Query: 550 TQSCCYLWCGKGCSGDEREMAKMVADTISRTEKQVVVEGQEPANFWMALGGKAPYANTKR 609
Q+ Y+W GKG S +E + A+ VA ++ + + + EG+EP FW +LGGK Y +
Sbjct: 299 PQNSGYIWVGKGASQEEEKGAEYVA-SVLKCKTLRIQEGEEPEEFWNSLGGKKDYQTSPL 357
Query: 610 LQEENLVITPRLFECSNKTGRFLATEIP-DFNQDDLEEDDVFLLDVWDQVFFWIGKHANE 668
L+ + PRL+ CSNKTGRF+ EIP +F QDDL EDDV LLD W+Q+F WIGK ANE
Sbjct: 358 LETQAEDHPPRLYGCSNKTGRFVIEEIPGEFTQDDLAEDDVMLLDAWEQIFIWIGKDANE 417
Query: 669 EEKKAAATTAQEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAWDPFKW 719
EKK + +A+ YL+T PSGRD TPI+++KQGHEPPTFTGWFL WD KW
Sbjct: 418 VEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSKW 468
Score = 101 bits (251), Expect = 3e-21
Identities = 102/361 (28%), Positives = 159/361 (44%), Gaps = 41/361 (11%)
Query: 5 SAQVKGSLNITTPG---LQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSYD 61
S Q+ N+ G ++IWR+E + V +++G F+ GDCYIIL +
Sbjct: 134 SPQMAAQHNMVDDGSGKVEIWRVENNGRIQVDQNSYGEFYGGDCYIILYTYPRGQI---- 189
Query: 62 IHYWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFK-QGLVIRKG 120
I+ W G +++ DE +A T Q+D L G+AVQ R QG E FK + L+I K
Sbjct: 190 IYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPVHLLSLFKDKPLIIYKN 249
Query: 121 GVASGMKHVETNSYDVQRLLHVKGKRNVVA----GEVEMSWKSFNRGDVFLLDLGKLIIQ 176
G + K RL V +RN+ + EV++ S N DVF+L L
Sbjct: 250 GTS---KKGGQAPAPPTRLFQV--RRNLASITRIVEVDVDANSLNSNDVFVLKL------ 298
Query: 177 WNGPESTRMERLRGMTLAKEIRDQERGGRTYVGVVDGENEL---ASPKLMEVMNHVLGKR 233
P+++ + + K +E G YV V L + E N + GK+
Sbjct: 299 ---PQNSGY-----IWVGKGASQEEEKGAEYVASVLKCKTLRIQEGEEPEEFWNSLGGKK 350
Query: 234 RELKAAVPDTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLSHEDCYILDQGGL 293
+ + +T E +LY S+ G V+ E+ TQD L+ +D +LD
Sbjct: 351 DYQTSPLLETQAE---DHPPRLYGCSNKTGRFVIEEIPGE-FTQDDLAEDDVMLLD-AWE 405
Query: 294 KIYVWKGKKANEQEKKGAMSHALNFIKA--KQYPPSTQVEVQNDGAESAVFQQLFQKWTA 351
+I++W GK ANE EKK ++ A +++ T + + G E F F W +
Sbjct: 406 QIFIWIGKDANEVEKKESLKSAKMYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDS 465
Query: 352 S 352
S
Sbjct: 466 S 466
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 270 bits (690), Expect = 4e-72
Identities = 218/786 (27%), Positives = 358/786 (45%), Gaps = 105/786 (13%)
Query: 17 PGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTAS-SLSYDIHYWIGQDSSLDEQ 75
PGL IW+IE V V + G F++ DCYI+L S SL+++I+YWIG +++LD++
Sbjct: 499 PGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKK 558
Query: 76 GAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETNSYD 135
+AI+ + ++L RE G+ESE F F + +GG ASG VE Y
Sbjct: 559 ACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHY- 617
Query: 136 VQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAK 195
V R+ V GK+N+ V + S + VFLLD G I W G ++T + A+
Sbjct: 618 VTRMYRVYGKKNIKLEPVPLKGTSLDPRFVFLLDRGLDIYVWRGAQATLSSTTKARLFAE 677
Query: 196 EIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVPDTVVEPALKAALKL 255
+I ER G+ + ++ EL P+ E + G+ E+K VP+ P KL
Sbjct: 678 KINKNERKGKAEITLLVQGQEL--PEFWEALG---GEPSEIKKHVPEDFWPP----QPKL 728
Query: 256 YHVSDSEGNLVVREV--------ATRP---------LTQDLLSHEDCYILDQGGLKIYVW 298
Y V G L + ++ RP L Q LL YILD +++W
Sbjct: 729 YKVGLGLGYLELPQINYKLSVEHKQRPKVELMPRMRLLQSLLDTRCVYILDCWS-DVFIW 787
Query: 299 KGKKANEQEKKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKWT-------A 351
G+K+ + A+ P V +G E+ VF+ F+ W
Sbjct: 788 LGRKSPRLVRAAALKLGQELCGMLHRPRHATVSRSLEGTEAQVFKAKFKNWDDVLTVDYT 847
Query: 352 SNRTSGLGKTHTVGSV----AKVEQVKFDATSMHVKPQ----VAAQQKMVDDGSGE---V 400
N + L G V K +Q+K D T++ + Q +A ++++++ + + +
Sbjct: 848 RNAEAVLQSPGLSGKVKRDAEKKDQMKADLTALFLPRQPPMSLAEAEQLMEEWNEDLDGM 907
Query: 401 QVWRIENLELVPVDSKWLGHFYGGDCYLLLYTYLI------------------------- 435
+ + +E + + + GHFY DCY+ L Y +
Sbjct: 908 EGFVLEGKKFARLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKKEDKEEKAEGKEGEEA 967
Query: 436 ----GEKQ-----HYLLYVWQGSQAS-QDEITASAYQAVILDQKYNGEPVQIRVPMGKEP 485
EKQ ++Y WQG +AS +T + + + G+ +R+ +E
Sbjct: 968 TAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQEN 1027
Query: 486 PHLMSIFKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTG-ANNTKAFEVPARANFLNSND 544
P +S FK + ++++G + ++ L+Q++ G A T+ ++ ++ LNS
Sbjct: 1028 PKFLSHFKRKFIIHRG---KRKAVQGAQQPSLYQIRTNGSALCTRCIQINTDSSLLNSEF 1084
Query: 545 VFVLK-------TQSCCYLWCGKGCSGDEREMAKMVADTISRT--EKQVVVEGQEPAN-F 594
F+LK Q Y W G+ DE ++A+ + +T+ T KQV+ EG+EP N F
Sbjct: 1085 CFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDTSYSKQVINEGEEPENFF 1144
Query: 595 WMALGGKAPYANTKRLQEENLVITPRLFECSNKTGRFLATE-IPDFNQDDLEEDDVFLLD 653
W+ +G + PY + + RLF CSN+ G F TE DF QDDL +DD+ LLD
Sbjct: 1145 WVGIGAQKPYDDDAEYMKHT-----RLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLD 1199
Query: 654 VWDQVFFWIGKHANEEEKKAAATTAQEYLKTHPSGRDPETP--IIVVKQGHEPPTFTGWF 711
+V+ W+G ++ E K + Q Y++ H ++ E P + +V++G+E FT F
Sbjct: 1200 NGQEVYMWVGTQTSQVEIKLSLKACQVYIQ-HMRSKEHERPRRLRLVRKGNEQHAFTRCF 1258
Query: 712 LAWDPF 717
AW F
Sbjct: 1259 HAWSAF 1264
>gi|63252913 gelsolin-like capping protein [Homo sapiens]
Length = 348
Score = 259 bits (663), Expect = 5e-69
Identities = 146/342 (42%), Positives = 201/342 (58%), Gaps = 14/342 (4%)
Query: 13 NITTPGLQIWRIEAMQMVPVPSSTFGSFFDGDCYIILAIHKTASSLSYDIHYWIGQDSSL 72
++ PGL +WR+E ++ VPV G FF GD Y++L H +S+ +H WIGQ SS
Sbjct: 15 SVQDPGLHVWRVEKLKPVPVAQENQGVFFSGDSYLVL--HNGPEEVSH-LHLWIGQQSSR 71
Query: 73 DEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVIRKGGVASGMKHVETN 132
DEQGA A+ ++ L R VQHREVQGNES+ F YF +GL ++GGV S T
Sbjct: 72 DEQGACAVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTG 131
Query: 133 S-YDVQRLLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGM 191
+ +++L VKGK+N+ A E ++W SFN GD F+LDLG+ I W G +S +ER +
Sbjct: 132 APAAIKKLYQVKGKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKAR 191
Query: 192 TLAKEIRDQERGGRTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVP--DTVVEPAL 249
LA IRD ER G+ V +V E A M VLG + LK P D + A
Sbjct: 192 DLALAIRDSERQGKAQVEIVTDGEEPAE------MIQVLGPKPALKEGNPEEDLTADKAN 245
Query: 250 KAALKLYHVSDSEGNLVVREVA-TRPLTQDLLSHEDCYILDQGGL-KIYVWKGKKANEQE 307
A LY VSD+ G + + +VA + P +LL +DC++LD G KIY+WKG+KANE+E
Sbjct: 246 AQAAALYKVSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKE 305
Query: 308 KKGAMSHALNFIKAKQYPPSTQVEVQNDGAESAVFQQLFQKW 349
++ A+ A FI QY P+TQVE+ G ES +F+Q F+ W
Sbjct: 306 RQAALQVAEGFISRMQYAPNTQVEILPQGHESPIFKQFFKDW 347
Score = 139 bits (351), Expect = 8e-33
Identities = 107/336 (31%), Positives = 165/336 (49%), Gaps = 30/336 (8%)
Query: 400 VQVWRIENLELVPVDSKWLGHFYGGDCYLLLYTYLIGEKQHYLLYVWQGSQASQDEITAS 459
+ VWR+E L+ VPV + G F+ GD YL+L+ G ++ L++W G Q+S+DE A
Sbjct: 21 LHVWRVEKLKPVPVAQENQGVFFSGDSYLVLHN---GPEEVSHLHLWIGQQSSRDEQGAC 77
Query: 460 AYQAVILDQKYNGEPVQIRVPMGKEPPHLMSIFKGRMVVYQGGT-SRTNNLETGPST--- 515
A AV L+ PVQ R G E MS F + +GG S + TG
Sbjct: 78 AVLAVHLNTLLGERPVQHREVQGNESDLFMSYFPRGLKYQEGGVESAFHKTSTGAPAAIK 137
Query: 516 RLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGCSGDEREMAKMVAD 575
+L+QV+ G N +A E + N+ D F+L + WCG + ER A+ +A
Sbjct: 138 KLYQVK--GKKNIRATERALNWDSFNTGDCFILDLGQNIFAWCGGKSNILERNKARDLAL 195
Query: 576 TISRTEKQ------VVVEGQEPANFWMALGGKAPYANTKRLQEENLVI------TPRLFE 623
I +E+Q +V +G+EPA LG K A + EE+L L++
Sbjct: 196 AIRDSERQGKAQVEIVTDGEEPAEMIQVLGPKP--ALKEGNPEEDLTADKANAQAAALYK 253
Query: 624 CSNKTGRFLATEIPDFNQDDLE---EDDVFLLD--VWDQVFFWIGKHANEEEKKAAATTA 678
S+ TG+ T++ D + LE DD F+LD + +++ W G+ ANE+E++AA A
Sbjct: 254 VSDATGQMNLTKVADSSPFALELLISDDCFVLDNGLCGKIYIWKGRKANEKERQAALQVA 313
Query: 679 QEYLKTHPSGRDPETPIIVVKQGHEPPTFTGWFLAW 714
+ ++ P T + ++ QGHE P F +F W
Sbjct: 314 EGFISRMQYA--PNTQVEILPQGHESPIFKQFFKDW 347
>gi|150417973 supervillin isoform 2 [Homo sapiens]
Length = 2214
Score = 177 bits (448), Expect = 5e-44
Identities = 199/799 (24%), Positives = 320/799 (40%), Gaps = 139/799 (17%)
Query: 139 LLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAKEIR 198
LL +KG+R+V VE + N GD FLL W G + +E+ + LA I+
Sbjct: 1445 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1504
Query: 199 DQERGG--RTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVP--DTVVEPALKAALK 254
+ G TY+ ++ + + + G+ A P D + E A+
Sbjct: 1505 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1564
Query: 255 LYHVSDSEGNLVVREVATRPLTQ-DLLSHEDCYILDQGGLKIYVWKGKKANEQEKKGAMS 313
+Y + D + LV + + + LL ++ + D G ++YVW GK+ ++K A
Sbjct: 1565 IYRLMDDK--LVPDDDYWGKIPKCSLLQPKEVLVFDFGS-EVYVWHGKEVTLAQRKIAFQ 1621
Query: 314 HA--------------LNFIKAKQYPPSTQVEVQN-----------DGAESAVFQQLFQK 348
A +N + + P + Q + E+ +F++ F
Sbjct: 1622 LAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLD 1681
Query: 349 WTASNRTS--GLGKTHTVGSVAKVEQVKFDATSMHVKPQVAA------------------ 388
WT R++ G+ + + +D T M PQ A
Sbjct: 1682 WTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEG 1741
Query: 389 -QQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYTYLI---------GE- 437
++ + S V VW I + + + +G F+ GD Y++ + +++ GE
Sbjct: 1742 HDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEH 1801
Query: 438 ------KQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSI 491
K+ + + WQG ++ E SA V LD++ Q++V GKEPP +
Sbjct: 1802 SVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGA---QVQVLQGKEPPCFLQC 1858
Query: 492 FKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKT- 550
F+G MVV+ G RL+ V+G EV + L S V+
Sbjct: 1859 FQGGMVVHSGRREEEEE-NVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNV 1917
Query: 551 -QSCCYLWCGKGCSGDEREMAKMVADTISR---------TEKQVVV----EGQEPANFWM 596
++ YLW G +E+ + A+ I + +V + EG EP FW
Sbjct: 1918 NKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWD 1977
Query: 597 ALGGKAPYANTKRLQEE-NLVITPRLFECSNKTGRFLATEIP------------DFNQDD 643
ALG + A LQ+ + PRLF S+ +G F ATE F Q+D
Sbjct: 1978 ALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQED 2037
Query: 644 L---EEDDVFLLDVWDQVFFWIGKHANEE------------EKKAAATTAQEYLKTHPSG 688
L + +FL+D +V+ W G E ++K+A T +Y K +
Sbjct: 2038 LYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGK-NL 2096
Query: 689 RDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYEDLKAELGNSRDWSQITAEVTSP 748
+ P ++ G EP TFT F +W+ + D ++IT T
Sbjct: 2097 KKPAPKSYLIHAGLEPLTFTNMFPSWE------------------HREDIAEITEMDTEV 2138
Query: 749 KVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAA 808
+ L+ I+PL L+ +P LPEGVDP + E +L+ EDF A MT
Sbjct: 2139 SNQITLVEDVLAKLCKTIYPLADLLARP---LPEGVDPLKLEIYLTDEDFEFALDMTRDE 2195
Query: 809 FSALPRWKQQNLKKEKGLF 827
++ALP WKQ NLKK KGLF
Sbjct: 2196 YNALPAWKQVNLKKAKGLF 2214
Score = 73.2 bits (178), Expect = 9e-13
Identities = 90/384 (23%), Positives = 154/384 (40%), Gaps = 58/384 (15%)
Query: 14 ITTPGLQIWRIEAMQMVPVPSSTFGSFFDGDCYII---LAIHKTASSLSYDIH------- 63
IT+ + +W I +P + G F +GD Y++ + S H
Sbjct: 1749 ITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGK 1808
Query: 64 ------YWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVI 117
+W G+ S++ E+G +A+ T ++D+ R Q + +QG E F F+ G+V+
Sbjct: 1809 EKCVYFFWQGRHSTVSEKGTSALMTVELDE---ERGAQVQVLQGKEPPCFLQCFQGGMVV 1865
Query: 118 RKGGVASGMKHVETNSYDVQRLLHVKGKRNVVAGEVEMSWKSF---NRGDVFLLDLGK-L 173
G + E N RL V+G+ V +E++ +R + +L++ K L
Sbjct: 1866 HSG----RREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKAL 1921
Query: 174 IIQWNGPESTRMERLRGMTLAKEIRDQ---ERGGRTYVGVVDGENELASPKLMEVMNHVL 230
I W+G ++ + G T A +I++Q E G + V E + S L L
Sbjct: 1922 IYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPL--GFWDAL 1979
Query: 231 GKRRELKAAVPDTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLS-----HEDC 285
G RR+ KA + A +L+ +S S G+ E ++S ED
Sbjct: 1980 G-RRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDL 2038
Query: 286 YILDQGGL-------KIYVWKGKKANE------------QEKKGAMSHALNFIKAKQY-P 325
Y Q L ++Y+W+G E ++K AM L + K K
Sbjct: 2039 YSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKK 2098
Query: 326 PSTQVEVQNDGAESAVFQQLFQKW 349
P+ + + + G E F +F W
Sbjct: 2099 PAPKSYLIHAGLEPLTFTNMFPSW 2122
Score = 60.5 bits (145), Expect = 6e-09
Identities = 69/273 (25%), Positives = 109/273 (39%), Gaps = 52/273 (19%)
Query: 503 TSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGC 562
T + +N P RL +Q G + + V RA+ LNS D F+L + CC+LW G+
Sbjct: 1429 TEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFA 1488
Query: 563 SGDEREMAKMVADTIS--------RTEKQVVVEG-----QEPANFWMALGGKAPYANTKR 609
+ E+ A +A I T Q + EG +FW LGG+ Y +
Sbjct: 1489 NVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGD 1548
Query: 610 LQEENLVITPRLFECSNKTGRFLATE-IPDFNQDD----------LEEDDVFLLDVWDQV 658
+E+ L + E +N R + + +PD DD L+ +V + D +V
Sbjct: 1549 PKEDEL-YEAAIIE-TNCIYRLMDDKLVPD---DDYWGKIPKCSLLQPKEVLVFDFGSEV 1603
Query: 659 FFWIGKHANEEEKKAAATTAQ-------EYLKTHPSGRDP-ETPIIVVKQGHEPP----- 705
+ W GK ++K A A+ +Y + DP E ++ ++G P
Sbjct: 1604 YVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIF 1663
Query: 706 ----------TFTGWFLAWDPFKWSNTKSYEDL 728
F FL W K SN K+ +L
Sbjct: 1664 GRLTEHNETILFKEKFLDWTELKRSNEKNPGEL 1696
>gi|150417971 supervillin isoform 1 [Homo sapiens]
Length = 1788
Score = 177 bits (448), Expect = 5e-44
Identities = 199/799 (24%), Positives = 320/799 (40%), Gaps = 139/799 (17%)
Query: 139 LLHVKGKRNVVAGEVEMSWKSFNRGDVFLLDLGKLIIQWNGPESTRMERLRGMTLAKEIR 198
LL +KG+R+V VE + N GD FLL W G + +E+ + LA I+
Sbjct: 1019 LLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFANVIEKAKASELATLIQ 1078
Query: 199 DQERGG--RTYVGVVDGENELASPKLMEVMNHVLGKRRELKAAVP--DTVVEPALKAALK 254
+ G TY+ ++ + + + G+ A P D + E A+
Sbjct: 1079 TKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYEAAIIETNC 1138
Query: 255 LYHVSDSEGNLVVREVATRPLTQ-DLLSHEDCYILDQGGLKIYVWKGKKANEQEKKGAMS 313
+Y + D + LV + + + LL ++ + D G ++YVW GK+ ++K A
Sbjct: 1139 IYRLMDDK--LVPDDDYWGKIPKCSLLQPKEVLVFDFGS-EVYVWHGKEVTLAQRKIAFQ 1195
Query: 314 HA--------------LNFIKAKQYPPSTQVEVQN-----------DGAESAVFQQLFQK 348
A +N + + P + Q + E+ +F++ F
Sbjct: 1196 LAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRLTEHNETILFKEKFLD 1255
Query: 349 WTASNRTS--GLGKTHTVGSVAKVEQVKFDATSMHVKPQVAA------------------ 388
WT R++ G+ + + +D T M PQ A
Sbjct: 1256 WTELKRSNEKNPGELAQHKEDPRTDVKAYDVTRMVSMPQTTAGTILDGVNVGRGYGLVEG 1315
Query: 389 -QQKMVDDGSGEVQVWRIENLELVPVDSKWLGHFYGGDCYLLLYTYLI---------GE- 437
++ + S V VW I + + + +G F+ GD Y++ + +++ GE
Sbjct: 1316 HDRRQFEITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEH 1375
Query: 438 ------KQHYLLYVWQGSQASQDEITASAYQAVILDQKYNGEPVQIRVPMGKEPPHLMSI 491
K+ + + WQG ++ E SA V LD++ Q++V GKEPP +
Sbjct: 1376 SVRAAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGA---QVQVLQGKEPPCFLQC 1432
Query: 492 FKGRMVVYQGGTSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKT- 550
F+G MVV+ G RL+ V+G EV + L S V+
Sbjct: 1433 FQGGMVVHSGRREEEEE-NVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNV 1491
Query: 551 -QSCCYLWCGKGCSGDEREMAKMVADTISR---------TEKQVVV----EGQEPANFWM 596
++ YLW G +E+ + A+ I + +V + EG EP FW
Sbjct: 1492 NKALIYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPLGFWD 1551
Query: 597 ALGGKAPYANTKRLQEE-NLVITPRLFECSNKTGRFLATEIP------------DFNQDD 643
ALG + A LQ+ + PRLF S+ +G F ATE F Q+D
Sbjct: 1552 ALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQED 1611
Query: 644 L---EEDDVFLLDVWDQVFFWIGKHANEE------------EKKAAATTAQEYLKTHPSG 688
L + +FL+D +V+ W G E ++K+A T +Y K +
Sbjct: 1612 LYSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGK-NL 1670
Query: 689 RDPETPIIVVKQGHEPPTFTGWFLAWDPFKWSNTKSYEDLKAELGNSRDWSQITAEVTSP 748
+ P ++ G EP TFT F +W+ + D ++IT T
Sbjct: 1671 KKPAPKSYLIHAGLEPLTFTNMFPSWE------------------HREDIAEITEMDTEV 1712
Query: 749 KVDVFNANSNLSSGPLPIFPLEQLVNKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAA 808
+ L+ I+PL L+ +P LPEGVDP + E +L+ EDF A MT
Sbjct: 1713 SNQITLVEDVLAKLCKTIYPLADLLARP---LPEGVDPLKLEIYLTDEDFEFALDMTRDE 1769
Query: 809 FSALPRWKQQNLKKEKGLF 827
++ALP WKQ NLKK KGLF
Sbjct: 1770 YNALPAWKQVNLKKAKGLF 1788
Score = 73.2 bits (178), Expect = 9e-13
Identities = 90/384 (23%), Positives = 154/384 (40%), Gaps = 58/384 (15%)
Query: 14 ITTPGLQIWRIEAMQMVPVPSSTFGSFFDGDCYII---LAIHKTASSLSYDIH------- 63
IT+ + +W I +P + G F +GD Y++ + S H
Sbjct: 1323 ITSVSVDVWHILEFDYSRLPKQSIGQFHEGDAYVVKWKFMVSTAVGSRQKGEHSVRAAGK 1382
Query: 64 ------YWIGQDSSLDEQGAAAIYTTQMDDFLKGRAVQHREVQGNESEAFRGYFKQGLVI 117
+W G+ S++ E+G +A+ T ++D+ R Q + +QG E F F+ G+V+
Sbjct: 1383 EKCVYFFWQGRHSTVSEKGTSALMTVELDE---ERGAQVQVLQGKEPPCFLQCFQGGMVV 1439
Query: 118 RKGGVASGMKHVETNSYDVQRLLHVKGKRNVVAGEVEMSWKSF---NRGDVFLLDLGK-L 173
G + E N RL V+G+ V +E++ +R + +L++ K L
Sbjct: 1440 HSG----RREEEEENVQSEWRLYCVRGEVPVEGNLLEVACHCSSLRSRTSMVVLNVNKAL 1495
Query: 174 IIQWNGPESTRMERLRGMTLAKEIRDQ---ERGGRTYVGVVDGENELASPKLMEVMNHVL 230
I W+G ++ + G T A +I++Q E G + V E + S L L
Sbjct: 1496 IYLWHGCKAQAHTKEVGRTAANKIKEQCPLEAGLHSSSKVTIHECDEGSEPL--GFWDAL 1553
Query: 231 GKRRELKAAVPDTVVEPALKAALKLYHVSDSEGNLVVREVATRPLTQDLLS-----HEDC 285
G RR+ KA + A +L+ +S S G+ E ++S ED
Sbjct: 1554 G-RRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFAATEFVYPARAPSVVSSMPFLQEDL 1612
Query: 286 YILDQGGL-------KIYVWKGKKANE------------QEKKGAMSHALNFIKAKQY-P 325
Y Q L ++Y+W+G E ++K AM L + K K
Sbjct: 1613 YSAPQPALFLVDNHHEVYLWQGWWPIENKITGSARIRWASDRKSAMETVLQYCKGKNLKK 1672
Query: 326 PSTQVEVQNDGAESAVFQQLFQKW 349
P+ + + + G E F +F W
Sbjct: 1673 PAPKSYLIHAGLEPLTFTNMFPSW 1696
Score = 60.5 bits (145), Expect = 6e-09
Identities = 69/273 (25%), Positives = 109/273 (39%), Gaps = 52/273 (19%)
Query: 503 TSRTNNLETGPSTRLFQVQGTGANNTKAFEVPARANFLNSNDVFVLKTQSCCYLWCGKGC 562
T + +N P RL +Q G + + V RA+ LNS D F+L + CC+LW G+
Sbjct: 1003 TEQNSNNSAVPYKRLMLLQIKGRRHVQTRLVEPRASALNSGDCFLLLSPHCCFLWVGEFA 1062
Query: 563 SGDEREMAKMVADTIS--------RTEKQVVVEG-----QEPANFWMALGGKAPYANTKR 609
+ E+ A +A I T Q + EG +FW LGG+ Y +
Sbjct: 1063 NVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGD 1122
Query: 610 LQEENLVITPRLFECSNKTGRFLATE-IPDFNQDD----------LEEDDVFLLDVWDQV 658
+E+ L + E +N R + + +PD DD L+ +V + D +V
Sbjct: 1123 PKEDEL-YEAAIIE-TNCIYRLMDDKLVPD---DDYWGKIPKCSLLQPKEVLVFDFGSEV 1177
Query: 659 FFWIGKHANEEEKKAAATTAQ-------EYLKTHPSGRDP-ETPIIVVKQGHEPP----- 705
+ W GK ++K A A+ +Y + DP E ++ ++G P
Sbjct: 1178 YVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIF 1237
Query: 706 ----------TFTGWFLAWDPFKWSNTKSYEDL 728
F FL W K SN K+ +L
Sbjct: 1238 GRLTEHNETILFKEKFLDWTELKRSNEKNPGEL 1270
>gi|166706885 erythrocyte membrane protein band 4.9 isoform 3 [Homo
sapiens]
Length = 358
Score = 64.3 bits (155), Expect = 4e-10
Identities = 35/75 (46%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Query: 755 ANSNLSSGPLPIFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSAL 812
+ S S L I+P E LV NK +LP GVD R E HLS EDF++ F M+P F L
Sbjct: 284 SGSETGSPGLQIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKL 343
Query: 813 PRWKQQNLKKEKGLF 827
WK+ LKK+ LF
Sbjct: 344 ALWKRNELKKKASLF 358
>gi|166706883 erythrocyte membrane protein band 4.9 isoform 2 [Homo
sapiens]
Length = 383
Score = 64.3 bits (155), Expect = 4e-10
Identities = 35/75 (46%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Query: 755 ANSNLSSGPLPIFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSAL 812
+ S S L I+P E LV NK +LP GVD R E HLS EDF++ F M+P F L
Sbjct: 309 SGSETGSPGLQIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKL 368
Query: 813 PRWKQQNLKKEKGLF 827
WK+ LKK+ LF
Sbjct: 369 ALWKRNELKKKASLF 383
>gi|166706881 erythrocyte membrane protein band 4.9 isoform 2 [Homo
sapiens]
Length = 383
Score = 64.3 bits (155), Expect = 4e-10
Identities = 35/75 (46%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Query: 755 ANSNLSSGPLPIFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSAL 812
+ S S L I+P E LV NK +LP GVD R E HLS EDF++ F M+P F L
Sbjct: 309 SGSETGSPGLQIYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKL 368
Query: 813 PRWKQQNLKKEKGLF 827
WK+ LKK+ LF
Sbjct: 369 ALWKRNELKKKASLF 383
>gi|166706877 erythrocyte membrane protein band 4.9 isoform 1 [Homo
sapiens]
Length = 405
Score = 61.6 bits (148), Expect = 3e-09
Identities = 32/64 (50%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P E LV NK +LP GVD R E HLS EDF++ F M+P F L WK+ LKK+
Sbjct: 342 IYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKK 401
Query: 824 KGLF 827
LF
Sbjct: 402 ASLF 405
>gi|166706879 erythrocyte membrane protein band 4.9 isoform 1 [Homo
sapiens]
Length = 405
Score = 61.6 bits (148), Expect = 3e-09
Identities = 32/64 (50%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P E LV NK +LP GVD R E HLS EDF++ F M+P F L WK+ LKK+
Sbjct: 342 IYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKK 401
Query: 824 KGLF 827
LF
Sbjct: 402 ASLF 405
>gi|166706875 erythrocyte membrane protein band 4.9 isoform 1 [Homo
sapiens]
Length = 405
Score = 61.6 bits (148), Expect = 3e-09
Identities = 32/64 (50%), Positives = 39/64 (60%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P E LV NK +LP GVD R E HLS EDF++ F M+P F L WK+ LKK+
Sbjct: 342 IYPYEMLVVTNKGRTKLPPGVDRMRLERHLSAEDFSRVFAMSPEEFGKLALWKRNELKKK 401
Query: 824 KGLF 827
LF
Sbjct: 402 ASLF 405
>gi|7662330 actin binding LIM protein family, member 3 [Homo
sapiens]
Length = 683
Score = 56.6 bits (135), Expect = 9e-08
Identities = 34/87 (39%), Positives = 47/87 (54%), Gaps = 6/87 (6%)
Query: 747 SPKVDVFNANS----NLSSGPLPIFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQ 800
+P D+F+ +S N I+P E L+ + LP+ VD +R E HLS E+F Q
Sbjct: 597 TPSADLFHYDSMNAVNWGMREYKIYPYELLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQ 656
Query: 801 AFGMTPAAFSALPRWKQQNLKKEKGLF 827
FGMT + F L WK+ LKK+ LF
Sbjct: 657 VFGMTISEFDRLALWKRNELKKQARLF 683
>gi|153792514 actin binding LIM protein family, member 2 isoform 6
[Homo sapiens]
Length = 521
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/64 (42%), Positives = 40/64 (62%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P + L+ N+ +LP+ VD +R E HLS E+F + FGM+ F L WK+ +LKK+
Sbjct: 458 IYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKK 517
Query: 824 KGLF 827
LF
Sbjct: 518 ALLF 521
>gi|194272204 actin binding LIM protein family, member 2 isoform 5
[Homo sapiens]
Length = 531
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/64 (42%), Positives = 40/64 (62%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P + L+ N+ +LP+ VD +R E HLS E+F + FGM+ F L WK+ +LKK+
Sbjct: 468 IYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKK 527
Query: 824 KGLF 827
LF
Sbjct: 528 ALLF 531
>gi|194272202 actin binding LIM protein family, member 2 isoform 4
[Homo sapiens]
Length = 559
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/64 (42%), Positives = 40/64 (62%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P + L+ N+ +LP+ VD +R E HLS E+F + FGM+ F L WK+ +LKK+
Sbjct: 496 IYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKK 555
Query: 824 KGLF 827
LF
Sbjct: 556 ALLF 559
>gi|194272200 actin binding LIM protein family, member 2 isoform 3
[Homo sapiens]
Length = 572
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/64 (42%), Positives = 40/64 (62%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P + L+ N+ +LP+ VD +R E HLS E+F + FGM+ F L WK+ +LKK+
Sbjct: 509 IYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKK 568
Query: 824 KGLF 827
LF
Sbjct: 569 ALLF 572
>gi|194272198 actin binding LIM protein family, member 2 isoform 2
[Homo sapiens]
Length = 611
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/64 (42%), Positives = 40/64 (62%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P + L+ N+ +LP+ VD +R E HLS E+F + FGM+ F L WK+ +LKK+
Sbjct: 548 IYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKK 607
Query: 824 KGLF 827
LF
Sbjct: 608 ALLF 611
>gi|194272196 actin binding LIM protein family, member 2 isoform 1
[Homo sapiens]
Length = 645
Score = 51.6 bits (122), Expect = 3e-06
Identities = 27/64 (42%), Positives = 40/64 (62%), Gaps = 2/64 (3%)
Query: 766 IFPLEQLV--NKPVEELPEGVDPSRKEEHLSIEDFTQAFGMTPAAFSALPRWKQQNLKKE 823
I+P + L+ N+ +LP+ VD +R E HLS E+F + FGM+ F L WK+ +LKK+
Sbjct: 582 IYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSIEEFDRLALWKRNDLKKK 641
Query: 824 KGLF 827
LF
Sbjct: 642 ALLF 645
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,358,095
Number of Sequences: 37866
Number of extensions: 1482014
Number of successful extensions: 3384
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2988
Number of HSP's gapped (non-prelim): 60
length of query: 827
length of database: 18,247,518
effective HSP length: 111
effective length of query: 716
effective length of database: 14,044,392
effective search space: 10055784672
effective search space used: 10055784672
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.