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Search of human proteins with 194248057
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194248057 growth associated protein 43 isoform 1 [Homo
sapiens]
(274 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens] 543 e-155
gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens] 446 e-125
gi|30795231 brain abundant, membrane attached signal protein 1 [... 66 3e-11
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 66 4e-11
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 66 4e-11
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 66 4e-11
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 66 4e-11
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 64 1e-10
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 64 1e-10
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 63 3e-10
gi|153070260 myristoylated alanine-rich protein kinase C substra... 62 7e-10
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 60 2e-09
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 60 2e-09
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 60 2e-09
gi|24415404 MDN1, midasin homolog [Homo sapiens] 57 1e-08
gi|157738619 smoothelin-like 1 [Homo sapiens] 56 3e-08
gi|117938759 GNAS complex locus XLas [Homo sapiens] 55 5e-08
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 55 7e-08
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 53 3e-07
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 53 3e-07
gi|42518068 trans-golgi network protein 2 [Homo sapiens] 53 3e-07
gi|14790190 spen homolog, transcriptional regulator [Homo sapiens] 52 7e-07
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 52 7e-07
gi|55956788 nucleolin [Homo sapiens] 51 1e-06
gi|104526627 triadin [Homo sapiens] 51 1e-06
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 50 3e-06
gi|7662162 ALEX2 protein [Homo sapiens] 49 5e-06
gi|29540562 ALEX2 protein [Homo sapiens] 49 5e-06
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 49 5e-06
gi|169658378 trinucleotide repeat containing 18 [Homo sapiens] 49 6e-06
>gi|194248057 growth associated protein 43 isoform 1 [Homo sapiens]
Length = 274
Score = 543 bits (1400), Expect = e-155
Identities = 274/274 (100%), Positives = 274/274 (100%)
Query: 1 MTKSCSELCHPALHFLPCLGGLRKNLQRAVRPSPYSLGFLTFWISRVEKNDDDQKIEQDG 60
MTKSCSELCHPALHFLPCLGGLRKNLQRAVRPSPYSLGFLTFWISRVEKNDDDQKIEQDG
Sbjct: 1 MTKSCSELCHPALHFLPCLGGLRKNLQRAVRPSPYSLGFLTFWISRVEKNDDDQKIEQDG 60
Query: 61 IKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEG 120
IKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEG
Sbjct: 61 IKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEG 120
Query: 121 TTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESAT 180
TTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESAT
Sbjct: 121 TTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESAT 180
Query: 181 KASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQ 240
KASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQ
Sbjct: 181 KASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQ 240
Query: 241 AEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
AEENIEAVDETKPKESARQDEGKEEEPEADQEHA
Sbjct: 241 AEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
>gi|4503911 growth associated protein 43 isoform 2 [Homo sapiens]
Length = 238
Score = 446 bits (1147), Expect = e-125
Identities = 228/229 (99%), Positives = 229/229 (100%)
Query: 46 RVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 105
+VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK
Sbjct: 10 QVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 69
Query: 106 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 165
DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA
Sbjct: 70 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 129
Query: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 225
SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA
Sbjct: 130 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 189
Query: 226 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA
Sbjct: 190 KATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 238
>gi|30795231 brain abundant, membrane attached signal protein 1
[Homo sapiens]
Length = 227
Score = 66.2 bits (160), Expect = 3e-11
Identities = 53/184 (28%), Positives = 79/184 (42%), Gaps = 9/184 (4%)
Query: 85 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 144
KK KG +D +A E + + A +G K+ E AE A A K ++P + E
Sbjct: 7 KKKKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGK-EKPDQDAEGK 65
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 204
+EEK+GE DAA A +AP + EK A A + A E PK A
Sbjct: 66 AEEKEGEKDAAA--AKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAA 123
Query: 205 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA----VDETKPKESARQD 260
+ AA +AA PAA + +K +P ++ A + ++ ++KP S
Sbjct: 124 EAAAAPAESAA--PAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGAPASDSKPGSSEAAP 181
Query: 261 EGKE 264
KE
Sbjct: 182 SSKE 185
Score = 60.8 bits (146), Expect = 1e-09
Identities = 62/189 (32%), Positives = 82/189 (43%), Gaps = 33/189 (17%)
Query: 49 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 108
K DQ E + E + AA K +A K + EK + A+AE K E
Sbjct: 55 KEKPDQDAEGKAEEKEGEKDAAAAKEEAP--------KAEPEKTEGAAEAKAEPPKAPEQ 106
Query: 109 P-VADGVEKKGEGTTTAEAA--PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 165
A G GE AEAA PA + P AGE PS+E EG+ +A P APA
Sbjct: 107 EQAAPGPAAGGEAPKAAEAAAAPAESAAP----AAGEEPSKE---EGEPKKTEA-PAAPA 158
Query: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAA 225
+ E K+ A + S++ +PSSK + PAA T A ++TP A+ AA
Sbjct: 159 AQETKSDGAPASDSKPGSSEAAPSSK-------------ETPAA-TEAPSSTPKAQGPAA 204
Query: 226 KATAQPPTE 234
A P E
Sbjct: 205 SAEEPKPVE 213
Score = 56.6 bits (135), Expect = 2e-08
Identities = 60/227 (26%), Positives = 97/227 (42%), Gaps = 32/227 (14%)
Query: 46 RVEKNDDDQKIEQDGIKPEDK-AHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 104
++ K + + K +DK A AAT+ + + + E + A AEA +
Sbjct: 4 KLSKKKKGYNVNDEKAKEKDKKAEGAATEEEGTPK----------ESEPQAAAEPAEAKE 53
Query: 105 KDEAPVAD----GVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 160
E P D EK+GE A A ++P++ A E +E K EQAA
Sbjct: 54 GKEKPDQDAEGKAEEKEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKA---PEQEQAA 110
Query: 161 PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-------- 212
P PA+ E +AE +A S +P++ E + + EPK+ + PAA A
Sbjct: 111 P-GPAAGGEAPKAAEAAAAPAESA--APAAGEEPSKEEGEPKKTEAPAAPAAQETKSDGA 167
Query: 213 -AAATTPAAEDAAAKATAQPPTETGESS--QAEENIEAVDETKPKES 256
A+ + P + +AA + P SS +A+ + +E KP E+
Sbjct: 168 PASDSKPGSSEAAPSSKETPAATEAPSSTPKAQGPAASAEEPKPVEA 214
Score = 43.1 bits (100), Expect = 3e-04
Identities = 39/147 (26%), Positives = 57/147 (38%), Gaps = 11/147 (7%)
Query: 139 KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESAT----KASTDNSPSSKAED 194
K G ++EK E D E AA + + +E A E A K D KAE+
Sbjct: 9 KKGYNVNDEKAKEKDKKAEGAATEEEGTPKESEPQAAAEPAEAKEGKEKPDQDAEGKAEE 68
Query: 195 -------APAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEA 247
A AKEE +A+ AA A + + A P GE+ +A E A
Sbjct: 69 KEGEKDAAAAKEEAPKAEPEKTEGAAEAKAEPPKAPEQEQAAPGPAAGGEAPKAAEAAAA 128
Query: 248 VDETKPKESARQDEGKEEEPEADQEHA 274
E+ + + +E EP+ + A
Sbjct: 129 PAESAAPAAGEEPSKEEGEPKKTEAPA 155
Score = 37.0 bits (84), Expect = 0.019
Identities = 30/84 (35%), Positives = 41/84 (48%), Gaps = 13/84 (15%)
Query: 104 KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 163
KK EAP A ++ T ++ APA+ SK PG + PS + E AATE AP +
Sbjct: 149 KKTEAPAAPAAQE-----TKSDGAPASDSK---PGSSEAAPSSK---ETPAATE--APSS 195
Query: 164 PASSEEKAGSAETESATKASTDNS 187
++ A SAE +A NS
Sbjct: 196 TPKAQGPAASAEEPKPVEAPAANS 219
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 65.9 bits (159), Expect = 4e-11
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 85 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 140
KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 141 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 195
G S+ K G+ + +E +SSEE + S E A KA S K A A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 196 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 255
PAKE P++ PA T PA A A + + E S +EE EA + KP
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431
Query: 256 SARQ 259
A Q
Sbjct: 432 KAPQ 435
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 69 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 123
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 124 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 178
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424
Query: 179 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 238
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482
Query: 239 SQAEENIEAVDETKPKESARQDEGK 263
E + A++ + K + + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 95 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 144
V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 199
+ K G A P+ + S E+ +E E+ + S K A APAK
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309
Query: 200 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361
Score = 47.8 bits (112), Expect = 1e-05
Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 24/192 (12%)
Query: 71 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 130
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1076 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134
Query: 131 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 190
G TPS + + A E + A S+ T T A NS +S
Sbjct: 1135 ---------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1182
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1183 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1231
Query: 251 TKPKESARQDEG 262
T P++S + +G
Sbjct: 1232 TTPQKSRKPKKG 1243
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 202
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659
Query: 203 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 246
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/249 (23%), Positives = 94/249 (37%), Gaps = 16/249 (6%)
Query: 29 AVRPSPYSLGFLTFWISRVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKK 86
A +P S G + D+ +E + +KP KA +TK + + K
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK 244
Query: 87 LKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSE 146
+ G+ V+ K+ + P + E EG+ + E APA G++ KA E +
Sbjct: 245 V-GDVTPQVKGGALPPAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQ 299
Query: 147 EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEP 201
+ A PA + A A K D+ SS+ E+ PA +
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359
Query: 202 KQADVPAAVT-AAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD 260
QA + AA+ PA E A PP +TG A +A + +S+ ++
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEE 416
Query: 261 EGKEEEPEA 269
EEE A
Sbjct: 417 SDSEEEAPA 425
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 63 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 122
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511
Query: 123 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 169
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 170 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 210
KAG + + DNS SS+ A E + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627
Query: 211 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 251
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 252 KPKESARQDEGKEEEPE 268
+P E + E + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704
Score = 42.4 bits (98), Expect = 4e-04
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)
Query: 62 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 113
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 114 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 166
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904
Query: 167 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 213
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 214 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 247
A TPA AA+ KA A T SS++E+ N+
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023
Query: 248 VDETKP--------------KESARQDEGKEEEPEADQ 271
+ P KES+R +GK++E A Q
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Score = 42.0 bits (97), Expect = 6e-04
Identities = 56/259 (21%), Positives = 95/259 (36%), Gaps = 34/259 (13%)
Query: 45 SRVEKNDDDQKIEQDG-IKPEDKAHKAATKIQASFR-----------GHITRKKLKGEKK 92
S E++D +++ E +KP K H+ + + G + K+
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQ 929
Query: 93 DDVQAAEAEANKKDEAPVADGVEK----------KGEGTTTAEAAPATGSKPDEPGKAGE 142
DD ++ E++ EAP A + A PA P KA
Sbjct: 930 DDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARA 989
Query: 143 TPSEEKKGEGDAATEQAAPQAPA------SSEEKAGSAETESATKASTDNSPSSKAEDAP 196
+ S + ++ E P ++ +A A KAS + SSK
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 197 A---KEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-PPTETGESSQAEENIEAVDETK 252
+ K+E V +AV AT+P + AK T + + E QA + E+ D++
Sbjct: 1050 SDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS- 1108
Query: 253 PKESARQDEGKEEEPEADQ 271
++S+ G EE+ E Q
Sbjct: 1109 -EDSSDSSSGSEEDGEGPQ 1126
Score = 38.1 bits (87), Expect = 0.008
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 46 RVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 103
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656
Query: 104 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 157
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Query: 158 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 190
A + KA S AE + +++S + S S
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 235
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 236 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
G +S + + +D G EE +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 31.2 bits (69), Expect = 1.0
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)
Query: 147 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 197
++K E DAA + + + +S EE+ AET AT + S D P+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 198 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 243
KE+ K A T + PA A + +A+P T S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Score = 30.4 bits (67), Expect = 1.7
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 91 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 150
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1187 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1243
Query: 151 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 193
G+ A Q+ +S K + E K D + S +
Sbjct: 1244 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1303
Query: 194 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
+++ D PAA T + A E A + + + T + + +
Sbjct: 1304 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1363
Query: 251 TKPKESARQDEGKEEEPEAD 270
K + + +G ++EPE +
Sbjct: 1364 EKKGKGSLGSQGAKDEPEEE 1383
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 65.9 bits (159), Expect = 4e-11
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 85 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 140
KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 141 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 195
G S+ K G+ + +E +SSEE + S E A KA S K A A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 196 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 255
PAKE P++ PA T PA A A + + E S +EE EA + KP
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431
Query: 256 SARQ 259
A Q
Sbjct: 432 KAPQ 435
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 69 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 123
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 124 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 178
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424
Query: 179 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 238
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482
Query: 239 SQAEENIEAVDETKPKESARQDEGK 263
E + A++ + K + + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 95 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 144
V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 199
+ K G A P+ + S E+ +E E+ + S K A APAK
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309
Query: 200 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361
Score = 47.4 bits (111), Expect = 1e-05
Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)
Query: 71 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 130
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1114 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1172
Query: 131 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 190
G P ET EE A E + A S+ T T A NS +S
Sbjct: 1173 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1219
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1220 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1268
Query: 251 TKPKESARQDEG 262
T P++S + +G
Sbjct: 1269 TTPQKSRKPKKG 1280
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 202
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659
Query: 203 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 246
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Score = 46.6 bits (109), Expect = 2e-05
Identities = 49/214 (22%), Positives = 80/214 (37%), Gaps = 51/214 (23%)
Query: 92 KDDVQAAEAEANKKDEAPVADGVEKKGE------GTTTAEAAPATGSKPDEPGKAGETPS 145
++D ++E E++ ++EA V+ G+ A+ +P G+ P PGK G + +
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 924
Query: 146 EEKK--------------GEGDAATEQA--------------APQAPASSEEKAGSAETE 177
+ K GE AA A +P PA++ +A +A T
Sbjct: 925 QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 984
Query: 178 SATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGE 237
+AS + SS +E P + + T P A A + G
Sbjct: 985 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASM----AGA 1040
Query: 238 SSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 271
SS KES+R +GK++E A Q
Sbjct: 1041 SSS-------------KESSRISDGKKQEGPATQ 1061
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/249 (23%), Positives = 94/249 (37%), Gaps = 16/249 (6%)
Query: 29 AVRPSPYSLGFLTFWISRVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKK 86
A +P S G + D+ +E + +KP KA +TK + + K
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK 244
Query: 87 LKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSE 146
+ G+ V+ K+ + P + E EG+ + E APA G++ KA E +
Sbjct: 245 V-GDVTPQVKGGALPPAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQ 299
Query: 147 EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEP 201
+ A PA + A A K D+ SS+ E+ PA +
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359
Query: 202 KQADVPAAVT-AAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD 260
QA + AA+ PA E A PP +TG A +A + +S+ ++
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEE 416
Query: 261 EGKEEEPEA 269
EEE A
Sbjct: 417 SDSEEEAPA 425
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 63 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 122
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511
Query: 123 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 169
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 170 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 210
KAG + + DNS SS+ A E + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627
Query: 211 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 251
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 252 KPKESARQDEGKEEEPE 268
+P E + E + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704
Score = 38.1 bits (87), Expect = 0.008
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 46 RVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 103
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656
Query: 104 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 157
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Query: 158 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 190
A + KA S AE + +++S + S S
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 235
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 236 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
G +S + + +D G EE +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 32.7 bits (73), Expect = 0.35
Identities = 33/169 (19%), Positives = 68/169 (40%), Gaps = 15/169 (8%)
Query: 102 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 161
++ K+ + ++DG +++G T ++ PA+ P + + A A
Sbjct: 1041 SSSKESSRISDGKKQEGPATQVSKKNPAS------------LPLTQAALKVLAQKASEAQ 1088
Query: 162 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 221
A ++ +G A++ S S +A+ +PK +V A T A ++ +E
Sbjct: 1089 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA-TKAPESSDDSE 1147
Query: 222 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 270
D++ ++ E GE Q ++ + T + +E E E D
Sbjct: 1148 DSSDSSSGS--EEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDD 1194
Score = 31.2 bits (69), Expect = 1.0
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)
Query: 147 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 197
++K E DAA + + + +S EE+ AET AT + S D P+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 198 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 243
KE+ K A T + PA A + +A+P T S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Score = 30.4 bits (67), Expect = 1.7
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 91 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 150
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1224 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1280
Query: 151 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 193
G+ A Q+ +S K + E K D + S +
Sbjct: 1281 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1340
Query: 194 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
+++ D PAA T + A E A + + + T + + +
Sbjct: 1341 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1400
Query: 251 TKPKESARQDEGKEEEPEAD 270
K + + +G ++EPE +
Sbjct: 1401 EKKGKGSLGSQGAKDEPEEE 1420
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 65.9 bits (159), Expect = 4e-11
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 85 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 140
KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 141 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 195
G S+ K G+ + +E +SSEE + S E A KA S K A A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 196 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 255
PAKE P++ PA T PA A A + + E S +EE EA + KP
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431
Query: 256 SARQ 259
A Q
Sbjct: 432 KAPQ 435
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 69 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 123
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 124 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 178
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424
Query: 179 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 238
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482
Query: 239 SQAEENIEAVDETKPKESARQDEGK 263
E + A++ + K + + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 95 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 144
V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 199
+ K G A P+ + S E+ +E E+ + S K A APAK
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309
Query: 200 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361
Score = 47.4 bits (111), Expect = 1e-05
Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)
Query: 71 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 130
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1076 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1134
Query: 131 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 190
G P ET EE A E + A S+ T T A NS +S
Sbjct: 1135 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1181
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1182 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1230
Query: 251 TKPKESARQDEG 262
T P++S + +G
Sbjct: 1231 TTPQKSRKPKKG 1242
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 202
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659
Query: 203 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 246
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/249 (23%), Positives = 94/249 (37%), Gaps = 16/249 (6%)
Query: 29 AVRPSPYSLGFLTFWISRVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKK 86
A +P S G + D+ +E + +KP KA +TK + + K
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK 244
Query: 87 LKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSE 146
+ G+ V+ K+ + P + E EG+ + E APA G++ KA E +
Sbjct: 245 V-GDVTPQVKGGALPPAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQ 299
Query: 147 EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEP 201
+ A PA + A A K D+ SS+ E+ PA +
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359
Query: 202 KQADVPAAVT-AAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD 260
QA + AA+ PA E A PP +TG A +A + +S+ ++
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEE 416
Query: 261 EGKEEEPEA 269
EEE A
Sbjct: 417 SDSEEEAPA 425
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 63 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 122
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511
Query: 123 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 169
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 170 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 210
KAG + + DNS SS+ A E + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627
Query: 211 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 251
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 252 KPKESARQDEGKEEEPE 268
+P E + E + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704
Score = 42.4 bits (98), Expect = 4e-04
Identities = 67/278 (24%), Positives = 104/278 (37%), Gaps = 71/278 (25%)
Query: 62 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 113
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 114 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 166
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904
Query: 167 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA----------- 213
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVD 963
Query: 214 -------AATTPAAEDAAA---KATAQPPTETGESSQAEE----------------NIEA 247
A TPA AA+ KA A T SS++E+ N+
Sbjct: 964 PNRSPAGPAATPAQAQAASTPRKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVT 1023
Query: 248 VDETKP--------------KESARQDEGKEEEPEADQ 271
+ P KES+R +GK++E A Q
Sbjct: 1024 MPTAHPRIAPKASMAGASSSKESSRISDGKKQEGPATQ 1061
Score = 42.0 bits (97), Expect = 6e-04
Identities = 56/259 (21%), Positives = 95/259 (36%), Gaps = 34/259 (13%)
Query: 45 SRVEKNDDDQKIEQDG-IKPEDKAHKAATKIQASFR-----------GHITRKKLKGEKK 92
S E++D +++ E +KP K H+ + + G + K+
Sbjct: 870 SSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQ 929
Query: 93 DDVQAAEAEANKKDEAPVADGVEK----------KGEGTTTAEAAPATGSKPDEPGKAGE 142
DD ++ E++ EAP A + A PA P KA
Sbjct: 930 DDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTPRKARA 989
Query: 143 TPSEEKKGEGDAATEQAAPQAPA------SSEEKAGSAETESATKASTDNSPSSKAEDAP 196
+ S + ++ E P ++ +A A KAS + SSK
Sbjct: 990 SESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASMAGASSSKESSRI 1049
Query: 197 A---KEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-PPTETGESSQAEENIEAVDETK 252
+ K+E V +AV AT+P + AK T + + E QA + E+ D++
Sbjct: 1050 SDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDS- 1108
Query: 253 PKESARQDEGKEEEPEADQ 271
++S+ G EE+ E Q
Sbjct: 1109 -EDSSDSSSGSEEDGEGPQ 1126
Score = 38.1 bits (87), Expect = 0.008
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 46 RVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 103
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656
Query: 104 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 157
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Query: 158 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 190
A + KA S AE + +++S + S S
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 235
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 236 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
G +S + + +D G EE +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 31.2 bits (69), Expect = 1.0
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)
Query: 147 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 197
++K E DAA + + + +S EE+ AET AT + S D P+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 198 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 243
KE+ K A T + PA A + +A+P T S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
Score = 30.4 bits (67), Expect = 1.7
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 91 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 150
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1186 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1242
Query: 151 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 193
G+ A Q+ +S K + E K D + S +
Sbjct: 1243 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1302
Query: 194 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
+++ D PAA T + A E A + + + T + + +
Sbjct: 1303 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1362
Query: 251 TKPKESARQDEGKEEEPEAD 270
K + + +G ++EPE +
Sbjct: 1363 EKKGKGSLGSQGAKDEPEEE 1382
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 65.9 bits (159), Expect = 4e-11
Identities = 54/184 (29%), Positives = 80/184 (43%), Gaps = 21/184 (11%)
Query: 85 KKLKGEKKDDVQAAEAE----ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA 140
KK + E + + +E+E A + + ++ + + + A+ P G+ P PGKA
Sbjct: 264 KKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPGKGATPAPPGKA 323
Query: 141 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDA 195
G S+ K G+ + +E +SSEE + S E A KA S K A A
Sbjct: 324 GAVASQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASA 376
Query: 196 PAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKE 255
PAKE P++ PA T PA A A + + E S +EE EA + KP
Sbjct: 377 PAKESPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSG 431
Query: 256 SARQ 259
A Q
Sbjct: 432 KAPQ 435
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 69 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 123
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 313 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 372
Query: 124 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 178
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 373 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 424
Query: 179 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 238
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 425 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 482
Query: 239 SQAEENIEAVDETKPKESARQDEGK 263
E + A++ + K + + K
Sbjct: 483 DSDREALAAMNAAQVKPLGKSPQVK 507
Score = 50.8 bits (120), Expect = 1e-06
Identities = 45/180 (25%), Positives = 78/180 (43%), Gaps = 24/180 (13%)
Query: 95 VQAAEAEANKKDEAPVADGVEKKGE----------GTTTAEAAPATGSKPDEPGKAGETP 144
V A +A+++ +D + +D + +G+ + + + +PA + P PGK G+
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAP-APGKVGDVT 249
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 199
+ K G A P+ + S E+ +E E+ + S K A APAK
Sbjct: 250 PQVKGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKG 309
Query: 200 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
P + PA A A A++ A P E ESS +EE+ ++ +ET ++ Q
Sbjct: 310 TPGKGATPAPPGKAGA-------VASQTKAGKPEEDSESS-SEESSDSEEETPAAKALLQ 361
Score = 47.8 bits (112), Expect = 1e-05
Identities = 52/205 (25%), Positives = 80/205 (39%), Gaps = 27/205 (13%)
Query: 83 TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE------ 136
T ++K EK++D +++E E++ +EA + K T A+A PA P
Sbjct: 750 TVTQVKAEKQEDSESSEEESDS-EEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISA 808
Query: 137 PGKA--------GETPSEEKKGEGDAATEQAAPQAPAS--SEEKAGSAETESATKASTDN 186
PGK +PS+ K + + PAS S KA + ++ T D+
Sbjct: 809 PGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDS 868
Query: 187 SPSSKAEDAPAKEEPKQADVPAAVT--AAAATTPAAEDAAAKATAQPPTETGESSQAEEN 244
S + D+ + E P+ T AA PA E A PP +TG S
Sbjct: 869 GSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPS------ 922
Query: 245 IEAVDETKPKESARQDEGKEEEPEA 269
A K +S E + + EA
Sbjct: 923 --AAQAGKQDDSGSSSEESDSDGEA 945
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 540 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 599
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 202
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 659
Query: 203 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 246
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 660 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 703
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/249 (23%), Positives = 94/249 (37%), Gaps = 16/249 (6%)
Query: 29 AVRPSPYSLGFLTFWISRVEKNDDDQKIE-QDGIKPED-KAHKAATKIQASFRGHITRKK 86
A +P S G + D+ +E + +KP KA +TK + + K
Sbjct: 185 AAKPGMVSAGQADSSSEDTSSSSDETDVEGKPSVKPAQVKASSVSTKESPARKAAPAPGK 244
Query: 87 LKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSE 146
+ G+ V+ K+ + P + E EG+ + E APA G++ KA E +
Sbjct: 245 V-GDVTPQVKGGALPPAKRAKKPEEES-ESSEEGSESEEEAPA-GTRSQV--KASEKILQ 299
Query: 147 EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEP 201
+ A PA + A A K D+ SS+ E+ PA +
Sbjct: 300 VRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKAL 359
Query: 202 KQADVPAAVT-AAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD 260
QA + AA+ PA E A PP +TG A +A + +S+ ++
Sbjct: 360 LQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEE 416
Query: 261 EGKEEEPEA 269
EEE A
Sbjct: 417 SDSEEEAPA 425
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 63 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 122
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 455 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 511
Query: 123 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 169
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 512 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 571
Query: 170 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 210
KAG + + DNS SS+ A E + PAA+
Sbjct: 572 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 627
Query: 211 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 251
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 628 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 687
Query: 252 KPKESARQDEGKEEEPE 268
+P E + E + E E
Sbjct: 688 RPAEDSSSSEESDSEEE 704
Score = 38.1 bits (87), Expect = 0.008
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 46 RVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 103
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 600 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 656
Query: 104 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 157
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 657 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 712
Query: 158 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 190
A + KA S AE + +++S + S S
Sbjct: 713 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 772
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 235
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 773 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 832
Query: 236 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
G +S + + +D G EE +E A
Sbjct: 833 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 881
Score = 36.6 bits (83), Expect = 0.024
Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 16/104 (15%)
Query: 92 KDDVQAAEAEANKKDEAPVADGVEKKGE------GTTTAEAAPATGSKPDEPGKAGETPS 145
++D ++E E++ ++EA V+ G+ A+ +P G+ P PGK G PS
Sbjct: 865 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTG--PS 922
Query: 146 EEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPS 189
+ G+ D + +SSEE E +A ++ D S
Sbjct: 923 AAQAGKQD--------DSGSSSEESDSDGEAPAAVTSAQDQESS 958
Score = 35.8 bits (81), Expect = 0.041
Identities = 43/169 (25%), Positives = 70/169 (41%), Gaps = 20/169 (11%)
Query: 62 KPEDKAHKAATKIQA-----SFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADG--- 113
K + KA+ AA + + S G + + +++ + N ++ +A G
Sbjct: 787 KTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPAS 846
Query: 114 VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK-------KGEGDAATEQAAPQAPAS 166
V G+ TA A TG + D E+ SEE+ K G +AA APA
Sbjct: 847 VPSVGKAVATAAQAQ-TGPEEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAA-LAPAK 904
Query: 167 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD--VPAAVTAA 213
+ G+A T K + + K +D+ + E +D PAAVT+A
Sbjct: 905 ESPRKGAAPTPPG-KTGPSAAQAGKQDDSGSSSEESDSDGEAPAAVTSA 952
Score = 31.2 bits (69), Expect = 1.0
Identities = 30/114 (26%), Positives = 45/114 (39%), Gaps = 17/114 (14%)
Query: 147 EKKGEGDAATEQAAPQ-------APASSEEKAGSAETESATKASTDNSPSSKAEDAPA-- 197
++K E DAA + + + +S EE+ AET AT + S D P+
Sbjct: 62 KRKAEEDAALQAKKTRVSDPISTSESSEEEEEAEAETAKATPRLASTNSSVLGADLPSSM 121
Query: 198 KEEPKQADVPAAVTAAAATTPAAEDAAA--------KATAQPPTETGESSQAEE 243
KE+ K A T + PA A + +A+P T S+ EE
Sbjct: 122 KEKAKAETEKAGKTGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEE 175
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 64.3 bits (155), Expect = 1e-10
Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 27/180 (15%)
Query: 95 VQAAEAEANKKDEAPVAD--GVEKKGE--------GTTTAEAAPATGSKPDEPGKAGETP 144
V A +A+++ +D + +D VE K + A+ P G+ P PGKAG
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 250
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 199
S+ K G+ + +E +SSEE + S E A KA S K A APAKE
Sbjct: 251 SQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303
Query: 200 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
P++ PA T PA A A + + E S +EE EA + KP A Q
Sbjct: 304 SPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSGKAPQ 358
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 69 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 123
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295
Query: 124 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 178
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 347
Query: 179 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 238
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 405
Query: 239 SQAEENIEAVDETKPKESARQDEGK 263
E + A++ + K + + K
Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVK 430
Score = 47.8 bits (112), Expect = 1e-05
Identities = 49/192 (25%), Positives = 77/192 (40%), Gaps = 24/192 (12%)
Query: 71 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 130
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1037 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1095
Query: 131 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 190
G TPS + + A E + A S+ T T A NS +S
Sbjct: 1096 ---------VGPTPSRTETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1143
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1144 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1192
Query: 251 TKPKESARQDEG 262
T P++S + +G
Sbjct: 1193 TTPQKSRKPKKG 1204
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 463 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 522
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 202
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 582
Query: 203 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 246
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 583 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Score = 46.6 bits (109), Expect = 2e-05
Identities = 49/214 (22%), Positives = 80/214 (37%), Gaps = 51/214 (23%)
Query: 92 KDDVQAAEAEANKKDEAPVADGVEKKGE------GTTTAEAAPATGSKPDEPGKAGETPS 145
++D ++E E++ ++EA V+ G+ A+ +P G+ P PGK G + +
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847
Query: 146 EEKK--------------GEGDAATEQA--------------APQAPASSEEKAGSAETE 177
+ K GE AA A +P PA++ +A +A T
Sbjct: 848 QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 907
Query: 178 SATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGE 237
+AS + SS +E P + + T P A A + G
Sbjct: 908 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASM----AGA 963
Query: 238 SSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 271
SS KES+R +GK++E A Q
Sbjct: 964 SSS-------------KESSRISDGKKQEGPATQ 984
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 63 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 122
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 378 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 434
Query: 123 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 169
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 435 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494
Query: 170 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 210
KAG + + DNS SS+ A E + PAA+
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 550
Query: 211 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 251
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 551 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 610
Query: 252 KPKESARQDEGKEEEPE 268
+P E + E + E E
Sbjct: 611 RPAEDSSSSEESDSEEE 627
Score = 41.6 bits (96), Expect = 8e-04
Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 9/168 (5%)
Query: 108 APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 167
A G+ G+ +++E ++ + D KA E + + A PA
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPP 243
Query: 168 EEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAATTPAAE 221
+ A A K D+ SS+ E+ PA + QA + AA+ PA E
Sbjct: 244 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303
Query: 222 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 269
A PP +TG A +A + +S+ ++ EEE A
Sbjct: 304 SPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 348
Score = 40.8 bits (94), Expect = 0.001
Identities = 51/226 (22%), Positives = 75/226 (33%), Gaps = 28/226 (12%)
Query: 44 ISRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 103
IS E ++++++ E + K AT AS + L K+ +A +A
Sbjct: 82 ISTSESSEEEEEAEAETAK--------ATPRLASTNSSVLGADLPSSMKEKAKAETEKAG 133
Query: 104 KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 163
K + + G T A + A T E + EG AA
Sbjct: 134 K-----TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA-- 186
Query: 164 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 223
K G A +S D S SS D K K V AA+ PA
Sbjct: 187 ------KPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV------RAASAPAKGTP 234
Query: 224 AAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 269
AT PP + G + ++ +E S + +EE P A
Sbjct: 235 GKGATPAPPGKAG-AVASQTKAGKPEEDSESSSEESSDSEEETPAA 279
Score = 38.1 bits (87), Expect = 0.008
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 46 RVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 103
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 579
Query: 104 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 157
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 580 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635
Query: 158 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 190
A + KA S AE + +++S + S S
Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 235
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 696 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 755
Query: 236 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
G +S + + +D G EE +E A
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804
Score = 31.6 bits (70), Expect = 0.78
Identities = 30/153 (19%), Positives = 62/153 (40%), Gaps = 20/153 (13%)
Query: 102 ANKKDEAPVADGVEKKGEGTTTAEAAPAT-----GSKPDEPGKAGETPSEEKKGEGDAAT 156
++ K+ + ++DG +++G T ++ PA+ + KA E + + +
Sbjct: 964 SSSKESSRISDGKKQEGPATQVSKKNPASLPLTQAALKVLAQKASEAQPPVARTQPSSGV 1023
Query: 157 EQAAPQAPASSEE-------------KAGSAETESATKA--STDNSPSSKAEDAPAKEEP 201
+ A PA+S + K E + ATKA S+D+S S + ++E+
Sbjct: 1024 DSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAPESSDDSEDSSDSSSGSEEDG 1083
Query: 202 KQADVPAAVTAAAATTPAAEDAAAKATAQPPTE 234
+ + TP+ + + TA +E
Sbjct: 1084 EGPQGAKSAHTLVGPTPSRTETLVEETAAESSE 1116
Score = 30.4 bits (67), Expect = 1.7
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 91 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 150
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1148 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1204
Query: 151 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 193
G+ A Q+ +S K + E K D + S +
Sbjct: 1205 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1264
Query: 194 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
+++ D PAA T + A E A + + + T + + +
Sbjct: 1265 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1324
Query: 251 TKPKESARQDEGKEEEPEAD 270
K + + +G ++EPE +
Sbjct: 1325 EKKGKGSLGSQGAKDEPEEE 1344
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 64.3 bits (155), Expect = 1e-10
Identities = 56/180 (31%), Positives = 78/180 (43%), Gaps = 27/180 (15%)
Query: 95 VQAAEAEANKKDEAPVAD--GVEKKGE--------GTTTAEAAPATGSKPDEPGKAGETP 144
V A +A+++ +D + +D VE K + A+ P G+ P PGKAG
Sbjct: 191 VSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVA 250
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK-----AEDAPAKE 199
S+ K G+ + +E +SSEE + S E A KA S K A APAKE
Sbjct: 251 SQTKAGKPEEDSE-------SSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303
Query: 200 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
P++ PA T PA A A + + E S +EE EA + KP A Q
Sbjct: 304 SPRKGAAPA---PPGKTGPAVAKAQAGKREEDSQSSSEESDSEE--EAPAQAKPSGKAPQ 358
Score = 57.4 bits (137), Expect = 1e-08
Identities = 47/205 (22%), Positives = 88/205 (42%), Gaps = 20/205 (9%)
Query: 69 KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN-KKDEAPVADGV-EKKGEGTTT--- 123
K AT G + + G+ ++D +++ E++ ++E P A + + K G T+
Sbjct: 236 KGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVG 295
Query: 124 -----AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 178
A+ +P G+ P PGK G ++ + G+ + ++ SS E++ S E
Sbjct: 296 AASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQ--------SSSEESDSEEEAP 347
Query: 179 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES 238
A + +P +A APAKE P++ PA AA+ K + + ES
Sbjct: 348 AQAKPSGKAPQVRAASAPAKESPRKGAAPAPPRKTGPA--AAQVQVGKQEEDSRSSSEES 405
Query: 239 SQAEENIEAVDETKPKESARQDEGK 263
E + A++ + K + + K
Sbjct: 406 DSDREALAAMNAAQVKPLGKSPQVK 430
Score = 47.4 bits (111), Expect = 1e-05
Identities = 51/192 (26%), Positives = 77/192 (40%), Gaps = 25/192 (13%)
Query: 71 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPAT 130
+T +QA + + KL E + +A E+ + +D + + G E+ GEG A++A
Sbjct: 1037 STSVQAKGTNKLRKPKLP-EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTL 1095
Query: 131 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 190
G P ET EE A E + A S+ T T A NS +S
Sbjct: 1096 GPTPSRT----ETLVEE------TAAESSEDDVVAPSQSLLSGYMTPGLTPA---NSQAS 1142
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
KA PK P+ ++T A +D K A+P G S EA
Sbjct: 1143 KAT-------PKLDSSPSV----SSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1191
Query: 251 TKPKESARQDEG 262
T P++S + +G
Sbjct: 1192 TTPQKSRKPKKG 1203
Score = 47.0 bits (110), Expect = 2e-05
Identities = 38/164 (23%), Positives = 63/164 (38%), Gaps = 5/164 (3%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
K E+ + + E+ + E P A ++ +A P + P KAG +
Sbjct: 463 KWEEDSESSSEESSDSSDGEVPTAVAPAQEKSLGNILQAKPTSSPAKGPPQKAGPVAVQV 522
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS-----TDNSPSSKAEDAPAKEEPK 202
K + +E + + ++ E+A +A T + K + T P A AK P
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKVAPV 582
Query: 203 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE 246
+ A A AT+PA A Q P E SS+ ++ E
Sbjct: 583 RVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEE 626
Score = 46.6 bits (109), Expect = 2e-05
Identities = 49/214 (22%), Positives = 80/214 (37%), Gaps = 51/214 (23%)
Query: 92 KDDVQAAEAEANKKDEAPVADGVEKKGE------GTTTAEAAPATGSKPDEPGKAGETPS 145
++D ++E E++ ++EA V+ G+ A+ +P G+ P PGK G + +
Sbjct: 788 EEDSGSSEEESDSEEEAETLAQVKPSGKTHQIRAALAPAKESPRKGAAPTPPGKTGPSAA 847
Query: 146 EEKK--------------GEGDAATEQA--------------APQAPASSEEKAGSAETE 177
+ K GE AA A +P PA++ +A +A T
Sbjct: 848 QAGKQDDSGSSSEESDSDGEAPAAVTSAQVIKPPLIFVDPNRSPAGPAATPAQAQAASTP 907
Query: 178 SATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGE 237
+AS + SS +E P + + T P A A + G
Sbjct: 908 RKARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAPKASM----AGA 963
Query: 238 SSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 271
SS KES+R +GK++E A Q
Sbjct: 964 SSS-------------KESSRISDGKKQEGPATQ 984
Score = 44.3 bits (103), Expect = 1e-04
Identities = 59/257 (22%), Positives = 89/257 (34%), Gaps = 58/257 (22%)
Query: 63 PEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTT 122
P K AA ++Q + +R E+ D + A A N P+ + K +T
Sbjct: 378 PPRKTGPAAAQVQVGKQEEDSRSS--SEESDSDREALAAMNAAQVKPLGKSPQVK-PAST 434
Query: 123 TAEAAPATGSKPDEPGKAG-----------ETPSEEKKGEGDAATEQAAPQAPASSEE-- 169
G+ P PGK G E SE E +++ P A A ++E
Sbjct: 435 MGMGPLGKGAGPVPPGKVGPATPSAQVGKWEEDSESSSEESSDSSDGEVPTAVAPAQEKS 494
Query: 170 -------------------KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 210
KAG + + DNS SS+ A E + PAA+
Sbjct: 495 LGNILQAKPTSSPAKGPPQKAGPVAVQVKAEKPMDNSESSEESSDSADSE----EAPAAM 550
Query: 211 TAAAA-----------------TTPAAEDAAAKATAQPPTETGESSQAEENIEAV--DET 251
TAA A TT +A+ A + Q P + G ++ + AV
Sbjct: 551 TAAQAKPALKIPQTKACPKKTNTTASAKVAPVRVGTQAPRKAGTATSPAGSSPAVAGGTQ 610
Query: 252 KPKESARQDEGKEEEPE 268
+P E + E + E E
Sbjct: 611 RPAEDSSSSEESDSEEE 627
Score = 41.6 bits (96), Expect = 8e-04
Identities = 39/168 (23%), Positives = 63/168 (37%), Gaps = 9/168 (5%)
Query: 108 APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 167
A G+ G+ +++E ++ + D KA E + + A PA
Sbjct: 184 AAAKPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPAPP 243
Query: 168 EEKAGSAETESATKASTDNSPSSK-----AEDAPAKEEPKQADVPAAVT-AAAATTPAAE 221
+ A A K D+ SS+ E+ PA + QA + AA+ PA E
Sbjct: 244 GKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKE 303
Query: 222 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 269
A PP +TG A +A + +S+ ++ EEE A
Sbjct: 304 SPRKGAAPAPPGKTG---PAVAKAQAGKREEDSQSSSEESDSEEEAPA 348
Score = 40.8 bits (94), Expect = 0.001
Identities = 51/226 (22%), Positives = 75/226 (33%), Gaps = 28/226 (12%)
Query: 44 ISRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 103
IS E ++++++ E + K AT AS + L K+ +A +A
Sbjct: 82 ISTSESSEEEEEAEAETAK--------ATPRLASTNSSVLGADLPSSMKEKAKAETEKAG 133
Query: 104 KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA 163
K + + G T A + A T E + EG AA
Sbjct: 134 K-----TGNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAA-- 186
Query: 164 PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 223
K G A +S D S SS D K K V AA+ PA
Sbjct: 187 ------KPGMVSAGQADSSSEDTSSSSDETDVEVKASEKILQV------RAASAPAKGTP 234
Query: 224 AAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 269
AT PP + G + ++ +E S + +EE P A
Sbjct: 235 GKGATPAPPGKAG-AVASQTKAGKPEEDSESSSEESSDSEEETPAA 279
Score = 38.1 bits (87), Expect = 0.008
Identities = 61/289 (21%), Positives = 101/289 (34%), Gaps = 67/289 (23%)
Query: 46 RVEKNDDDQKIEQDGIKPED--KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN 103
+ EK D+ + ++ D +A A T QA I + K +K + +A+
Sbjct: 523 KAEKPMDNSESSEESSDSADSEEAPAAMTAAQAKPALKIPQTKACPKKTNTTASAKV--- 579
Query: 104 KKDEAPVADGVE---KKGEGTTTAEAAPATGS---KPDEPGKAGETPSEEKKGEGDAATE 157
APV G + K G T+ A ++PA +P E + E E++ G A T
Sbjct: 580 ----APVRVGTQAPRKAGTATSPAGSSPAVAGGTQRPAEDSSSSEESDSEEEKTGLAVTV 635
Query: 158 QAAPQAPASSEEKAGS---------------------------AETESATKASTDNSPSS 190
A + KA S AE + +++S + S S
Sbjct: 636 GQAKSVGKGLQVKAASVPVKGSLGQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSE 695
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAE----------DAAAKATAQPPTET----- 235
+A +PA+ + A AAA P+A+ AAA+A + P++
Sbjct: 696 EAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVR 755
Query: 236 ----------GESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
G +S + + +D G EE +E A
Sbjct: 756 NPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESDSEEEA 804
Score = 32.7 bits (73), Expect = 0.35
Identities = 33/169 (19%), Positives = 68/169 (40%), Gaps = 15/169 (8%)
Query: 102 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 161
++ K+ + ++DG +++G T ++ PA+ P + + A A
Sbjct: 964 SSSKESSRISDGKKQEGPATQVSKKNPAS------------LPLTQAALKVLAQKASEAQ 1011
Query: 162 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 221
A ++ +G A++ S S +A+ +PK +V A T A ++ +E
Sbjct: 1012 PPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQA-TKAPESSDDSE 1070
Query: 222 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 270
D++ ++ E GE Q ++ + T + +E E E D
Sbjct: 1071 DSSDSSSGS--EEDGEGPQGAKSAHTLGPTPSRTETLVEETAAESSEDD 1117
Score = 30.4 bits (67), Expect = 1.7
Identities = 37/200 (18%), Positives = 67/200 (33%), Gaps = 23/200 (11%)
Query: 91 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 150
K D + + KD+ DG ++ +P TG K G + + KKG
Sbjct: 1147 KLDSSPSVSSTLAAKDDP---DGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKPKKG 1203
Query: 151 EGDAATEQAAPQA-----------------PASSEEKAGSAETESATKASTDNSPSSKAE 193
G+ A Q+ +S K + E K D + S +
Sbjct: 1204 AGNPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRK 1263
Query: 194 DAPAKEEPKQADVPAAVTAAAATTP---AAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
+++ D PAA T + A E A + + + T + + +
Sbjct: 1264 GWESRKRKLSGDQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVK 1323
Query: 251 TKPKESARQDEGKEEEPEAD 270
K + + +G ++EPE +
Sbjct: 1324 EKKGKGSLGSQGAKDEPEEE 1343
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 62.8 bits (151), Expect = 3e-10
Identities = 65/243 (26%), Positives = 114/243 (46%), Gaps = 32/243 (13%)
Query: 47 VEKNDDDQKIEQDGIKPEDKAH-KAATKIQASFRGHITRKKLKGE---KKDDVQAAEAEA 102
+++ +++ + E DG++ + K+ + A +++ +K +G+ + D V+A EAE
Sbjct: 2009 MQEAEEEAQPESDGVEAQPKSEGEEAQEVEGE------TQKTEGDAQPESDGVEAPEAE- 2061
Query: 103 NKKDEAPVADGVEKKGEGTTTAE-----AAPATG-SKPDEPG-KAGETPSEEKKGEGDAA 155
+EA A+G ++ EG E A A G ++P+ G +A E E +K EG A
Sbjct: 2062 ---EEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEA 2118
Query: 156 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA--AVTAA 213
E P S +A AE E+ + S +A+DA + +P+ + A A A
Sbjct: 2119 PETEGEAQPESEGIEAPEAEGEAQPE-----SEGVEAQDAEGEAQPESEGIEAQEAEEEA 2173
Query: 214 AATTPAAEDAAAKATAQPPTETGESSQAE----ENIEAVDETKPKESARQDEGKEEEPEA 269
E A+ AQP +E E+ +AE +E V+ + +E A+ + E PEA
Sbjct: 2174 QPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEA 2233
Query: 270 DQE 272
+ E
Sbjct: 2234 EGE 2236
Score = 62.0 bits (149), Expect = 5e-10
Identities = 64/242 (26%), Positives = 101/242 (41%), Gaps = 42/242 (17%)
Query: 48 EKNDDDQKIEQDGIKP---EDKAHKAATKIQASFRGHITRKKLKGEKKD-DVQAAEAEAN 103
+K + D + E DG++ E++A +A ++Q + + E +D D Q AE EA
Sbjct: 2042 QKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEA------EGEAHPESEDVDAQEAEGEAQ 2095
Query: 104 KKDE---APVADGVEKKGEGT----TTAEAAPATGS--KPDEPGKA-------------G 141
+ E AP A+G +K EG T EA P + P+ G+A G
Sbjct: 2096 PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEG 2155
Query: 142 ETPSEEKKGEGDAATEQAAPQ-----APASSEEKAGSAETESATKASTDNSPSSKAEDAP 196
E E + E A E+A P+ AP + E +E A +A + P + +AP
Sbjct: 2156 EAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAP 2215
Query: 197 -----AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDET 251
A+ EP+ + P A A + K + Q G+S +A E+ V E
Sbjct: 2216 EAEEEAQPEPEGVETPEAEGEAQPESEGETQGEKKGSPQVSLGDGQSEEASESSSPVPED 2275
Query: 252 KP 253
+P
Sbjct: 2276 RP 2277
Score = 60.8 bits (146), Expect = 1e-09
Identities = 59/230 (25%), Positives = 94/230 (40%), Gaps = 17/230 (7%)
Query: 49 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 108
+ ++ Q++E + K E A + ++A ++ E + +VQ AE EA+ + E
Sbjct: 2030 EGEEAQEVEGETQKTEGDAQPESDGVEAP-----EAEEEAQEAEGEVQEAEGEAHPESED 2084
Query: 109 PVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPS-EEKKGEGDAATEQAAPQAPASS 167
D E +GE +E A P+ G+A + E + EG+A E +AP +
Sbjct: 2085 --VDAQEAEGEAQPESEGVEA----PEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAE 2138
Query: 168 EEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ-----ADVPAAVTAAAATTPAAED 222
E +E A A + P S+ +A EE Q + P A A + E
Sbjct: 2139 GEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEA 2198
Query: 223 AAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 272
A+ AQP E E+ +AEE + E A + E E E E
Sbjct: 2199 PEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQGE 2248
Score = 58.5 bits (140), Expect = 6e-09
Identities = 61/204 (29%), Positives = 95/204 (46%), Gaps = 28/204 (13%)
Query: 96 QAAEAEANKKDEAPVADGVEKKGE--GTTTAEAAPATG-SKPDEPG-KAGETPSEEKKGE 151
Q + E N + EA A G + G+ G EA A G ++P+ G +A E + ++ E
Sbjct: 1806 QGSGHEDNLQGEA-AAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAE 1864
Query: 152 GDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE---EPKQADVPA 208
G+A E +AP + E +E +A + P S+ +AP E +P+ V A
Sbjct: 1865 GEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEA 1924
Query: 209 AVT-------AAAATTPAAEDAA--AKATAQPPTETGESSQAE-------ENIEAVD--- 249
T + A AE+AA A+ QP +E ES +AE E++EA++
Sbjct: 1925 LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV 1984
Query: 250 ETKPKESARQDEGKE-EEPEADQE 272
ET+ E Q E ++ E PEA+ E
Sbjct: 1985 ETQEAEGEAQPESEDVEAPEAEGE 2008
Score = 57.4 bits (137), Expect = 1e-08
Identities = 54/195 (27%), Positives = 81/195 (41%), Gaps = 20/195 (10%)
Query: 97 AAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSE-------EKK 149
A EAE + E+ V + E + E +E A + + GE E E +
Sbjct: 1947 AQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAE 2006
Query: 150 GEGDAATEQAAPQA------PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 203
GE A E+A P++ P S E+A E E+ K D P S +AP EE Q
Sbjct: 2007 GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQ-KTEGDAQPESDGVEAPEAEEEAQ 2065
Query: 204 ADVPAAVTAAAATTPAAEDA---AAKATAQPPTETGESSQAE---ENIEAVDETKPKESA 257
A P +ED A+ AQP +E E+ +AE + E ++ + + A
Sbjct: 2066 EAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEA 2125
Query: 258 RQDEGKEEEPEADQE 272
+ + E PEA+ E
Sbjct: 2126 QPESEGIEAPEAEGE 2140
Score = 57.0 bits (136), Expect = 2e-08
Identities = 55/196 (28%), Positives = 89/196 (45%), Gaps = 27/196 (13%)
Query: 90 EKKDDVQAAEAEANKKDE---APVADG-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPS 145
E + D Q AE EA + E AP A+G + + E T EA +P+ G E P
Sbjct: 1855 EAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEV--QPESEG--AEAPE 1910
Query: 146 EEKKGEGDA----ATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSK---AEDAPAK 198
EK+ + + A E P S +A AE E+A +A P S+ +++A +
Sbjct: 1911 AEKEAQPETESVEALETEGEDEPESEGAEAQEAE-EAAQEAEGQTQPESEVIESQEAEEE 1969
Query: 199 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 258
+P+ DV A E A+ AQP +E E+ +AE ++ +E E+
Sbjct: 1970 AQPESEDVEALEVEV-------ETQEAEGEAQPESEDVEAPEAEGEMQEAEE----EAQP 2018
Query: 259 QDEGKEEEPEADQEHA 274
+ +G E +P+++ E A
Sbjct: 2019 ESDGVEAQPKSEGEEA 2034
Score = 52.4 bits (124), Expect = 4e-07
Identities = 52/201 (25%), Positives = 86/201 (42%), Gaps = 21/201 (10%)
Query: 89 GEKKDDVQAAEAEANKKDEAPVADG----VEKKGEGTTTAEAAPATGSKPDE--PGKAG- 141
GE + D A E E + A E++GEG + GS ++ G+A
Sbjct: 1761 GEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAA 1820
Query: 142 ---ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP-- 196
+ P + EG A E P S +A AE + A +A + P S+ +AP
Sbjct: 1821 GGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGD-AQEAEGEAQPESEDVEAPEA 1879
Query: 197 ---AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES----SQAEENIEAVD 249
A+ E + + P A + AE A+ AQP TE+ E+ + E E +
Sbjct: 1880 EGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAE 1939
Query: 250 ETKPKESARQDEGKEEEPEAD 270
+ +E+A++ EG + +PE++
Sbjct: 1940 AQEAEEAAQEAEG-QTQPESE 1959
Score = 51.6 bits (122), Expect = 7e-07
Identities = 45/182 (24%), Positives = 84/182 (46%), Gaps = 8/182 (4%)
Query: 91 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 150
+ + +A EAE + E + +E +GE +E A A ++ G+T E +
Sbjct: 1902 ESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVI 1961
Query: 151 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP-AKEEPKQADVPAA 209
E A E+A P+ S + +A E E+ +A + P S+ +AP A+ E ++A+ A
Sbjct: 1962 ESQEAEEEAQPE---SEDVEALEVEVET-QEAEGEAQPESEDVEAPEAEGEMQEAEEEAQ 2017
Query: 210 VTA-AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 268
+ P +E A+ +T +Q E + V+ + +E A++ EG+ +E E
Sbjct: 2018 PESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPES--DGVEAPEAEEEAQEAEGEVQEAE 2075
Query: 269 AD 270
+
Sbjct: 2076 GE 2077
Score = 50.8 bits (120), Expect = 1e-06
Identities = 53/201 (26%), Positives = 89/201 (44%), Gaps = 19/201 (9%)
Query: 91 KKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKG 150
+ +DV+A EAE + E+ + E + E +E A A ++ + + + E +G
Sbjct: 1870 ESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEG 1929
Query: 151 EGDAATEQA-APQAPASSEEKAGSAETESATKAS--TDNSPSSKAEDAPAKE---EPKQA 204
E + +E A A +A +++E G + ES S + ++ED A E E ++A
Sbjct: 1930 EDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEA 1989
Query: 205 DVPAAVTAAAATTPAAEDAAAKAT--AQPPTETGES---SQAEENIEAVDETKPKESARQ 259
+ A + P AE +A AQP ++ E+ S+ EE E ET+ E Q
Sbjct: 1990 EGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQ 2049
Query: 260 DEG--------KEEEPEADQE 272
E +EE EA+ E
Sbjct: 2050 PESDGVEAPEAEEEAQEAEGE 2070
Score = 40.8 bits (94), Expect = 0.001
Identities = 37/164 (22%), Positives = 71/164 (43%), Gaps = 8/164 (4%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
+G + ++ + E E +++EA + + E GEG + E G GE E
Sbjct: 1334 EGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEG 1393
Query: 148 KKGEG--DAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD 205
K EG + + + ASS + GS E + + + S+ AE PA+ + +
Sbjct: 1394 LKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRA-SASAEPCPAEGTEEPTE 1452
Query: 206 VPAAVTAAAATTPAAEDAAAKATAQPPTE--TGESSQAEENIEA 247
P+ + + T P+A + + + +P E G + +E+ +A
Sbjct: 1453 PPSHL---SETDPSASERQSGSQLEPGLEKPPGATMMGQEHTQA 1493
Score = 40.0 bits (92), Expect = 0.002
Identities = 53/218 (24%), Positives = 86/218 (39%), Gaps = 15/218 (6%)
Query: 66 KAHKAATK--IQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTT 123
KA AT+ I+ +F ++ +GE D +AAE K P + + EG
Sbjct: 1673 KATMGATRGPIKEAFDLQQILQRKRGEHTDG-EAAEVAPGKTHTDPTSTRTVQGAEGGLG 1731
Query: 124 AEAAPATGSKPDEPGKAGETPSEEK-----KGEGDAATEQAAPQAPASSEEKAGSAETES 178
+ G E G+ + + +K + EGDA ++ + +SE AGS E+
Sbjct: 1732 PGLSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKT-HNSETSAGSELGEA 1790
Query: 179 ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED---AAAKATAQPPTET 235
+ + E+ Q + A + AE A+ AQP +E
Sbjct: 1791 EQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEG 1850
Query: 236 GESSQAEENI-EAVDETKPKESARQDEGKEEEPEADQE 272
E+ +AE + EA E +P+ + E E E EA E
Sbjct: 1851 VEAPEAEGDAQEAEGEAQPE--SEDVEAPEAEGEAQPE 1886
Score = 32.7 bits (73), Expect = 0.35
Identities = 37/161 (22%), Positives = 64/161 (39%), Gaps = 21/161 (13%)
Query: 88 KGEKKDDVQAAEAEANK----KDEAPVADGVEKKGEGTTTAEAA---------PATGSKP 134
+G+++++ Q E E ++E + V++ EG EA P GS
Sbjct: 1347 EGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVH 1406
Query: 135 DEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEE--KAGSAETESATKASTDNSPSSKA 192
+ +P + E D E+ A +A AS+E G+ E ++ PS+
Sbjct: 1407 GQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEPPSHLSETDPSASE 1466
Query: 193 EDAPAKEEPKQADVPAAV------TAAAATTPAAEDAAAKA 227
+ ++ EP P A T A T AAE +++ A
Sbjct: 1467 RQSGSQLEPGLEKPPGATMMGQEHTQAQPTQGAAERSSSVA 1507
Score = 30.8 bits (68), Expect = 1.3
Identities = 25/120 (20%), Positives = 50/120 (41%), Gaps = 9/120 (7%)
Query: 119 EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETES 178
+G +A + G++ G GE P G G EQ P + E+ S+++ +
Sbjct: 478 DGVDSASPSAQIGAERKAGGSLGEDPGLCIDGAGLGGPEQGGRLTPRARSEEGASSDSSA 537
Query: 179 ATKASTDNSP--------SSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 230
+T + +S KA +++E + PA+ A + ++ ++D A+ Q
Sbjct: 538 STGSHEGSSEWGGRPQGCPGKARAETSQQEASEGGDPAS-PALSLSSLRSDDLQAETQGQ 596
Score = 29.3 bits (64), Expect = 3.9
Identities = 42/195 (21%), Positives = 66/195 (33%), Gaps = 22/195 (11%)
Query: 92 KDDVQAAEAEANKKDEAPVAD-GVEKKGEGT---TTAEAAPATGSKPDEPGKAGETPSEE 147
KD + E + KD P D G ++ G T ++A P GS + S
Sbjct: 1142 KDSPRYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQALPDLGSHAMTENFTPTSSSGV 1201
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 207
G + +++ P + + + TE K S S E E +Q P
Sbjct: 1202 DISSGSGGSGESS--VPCAMDGTLVTQGTELPLKTSNQRPDSRTYESPGDLENQQQCCFP 1259
Query: 208 AAVTAAAATTPAAEDAA----------------AKATAQPPTETGESSQAEENIEAVDET 251
+ A A ED A A+ T Q + E+ + E +E
Sbjct: 1260 TFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEEVQLEETKEGTEGEGLQEEA 1319
Query: 252 KPKESARQDEGKEEE 266
E + +EG +EE
Sbjct: 1320 VQLEETKTEEGLQEE 1334
>gi|153070260 myristoylated alanine-rich protein kinase C substrate
[Homo sapiens]
Length = 332
Score = 61.6 bits (148), Expect = 7e-10
Identities = 49/196 (25%), Positives = 84/196 (42%), Gaps = 24/196 (12%)
Query: 66 KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD-------EAPVADGVEKKG 118
KA AT ++ +K+ +K + + NKK+ EAP A+G + +
Sbjct: 137 KAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEA 196
Query: 119 EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQA--------PASSEEK 170
G A AA A + ++ GE + ++G ++A PQ PAS E K
Sbjct: 197 AGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAAGGDPQEAKPQEAAVAPEKPPASDETK 256
Query: 171 AGSAET--------ESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED 222
A + E+ A+ +PS+ AP ++E A+ PAA A++A +++
Sbjct: 257 AAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAPPEQEAAPAEEPAAAAASSACAAPSQE 316
Query: 223 AAAKATAQ-PPTETGE 237
A + + + PP E E
Sbjct: 317 AQPECSPEAPPAEAAE 332
Score = 52.4 bits (124), Expect = 4e-07
Identities = 64/222 (28%), Positives = 87/222 (39%), Gaps = 61/222 (27%)
Query: 106 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPA 165
D +P A K E A A +P G +PS +KGE AA AAP+A A
Sbjct: 44 DASPAAAESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAA---AAPEAGA 100
Query: 166 SSEEKAG-------------SAETESATKASTDNSPSSKAED----APAKEEPK------ 202
S EK +AE E+A+ AS+ +SP KAED +P+ E PK
Sbjct: 101 SPVEKEAPAEGEAAEPGSPTAAEGEAASAASSTSSP--KAEDGATPSPSNETPKKKKKRF 158
Query: 203 ------------------------QADVPAAV----TAAAATTPAAEDAAAKATAQPPTE 234
+A+ PAA AA AA +A A + Q
Sbjct: 159 SFKKSFKLSGFSFKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAP 218
Query: 235 TGESSQAEENIEAVD--ETKPKESARQDEGKEEEPEADQEHA 274
E++ EE D E KP+E+A E+ P +D+ A
Sbjct: 219 GEEAAAGEEGAAGGDPQEAKPQEAA---VAPEKPPASDETKA 257
Score = 46.6 bits (109), Expect = 2e-05
Identities = 66/253 (26%), Positives = 89/253 (35%), Gaps = 41/253 (16%)
Query: 58 QDGIKPEDKAH---KAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK---KDEAPVA 111
+ G K E +A+ AA K + + G EK + AA EA + EAP
Sbjct: 51 ESGAKEELQANGSAPAADKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAE 110
Query: 112 DGVEKKGEGTTT----AEAAPATGSKPDE----PGKAGETPSEEKKG------------- 150
+ G T A AA +T S E P + ETP ++KK
Sbjct: 111 GEAAEPGSPTAAEGEAASAASSTSSPKAEDGATPSPSNETPKKKKKRFSFKKSFKLSGFS 170
Query: 151 ------EGDAATEQAAPQAPASSEEKAGSAETESATK-ASTDNSPSSKAEDAPAKEEPKQ 203
E E AP A +E AG A +A A++ ++ E+A A EE
Sbjct: 171 FKKNKKEAGEGGEAEAPAAEGGKDEAAGGAAAAAAEAGAASGEQAAAPGEEAAAGEEGAA 230
Query: 204 ADVPA-AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEE------NIEAVDETKPKES 256
P A AA P A+ + A E +AEE EA P
Sbjct: 231 GGDPQEAKPQEAAVAPEKPPASDETKAAEEPSKVEEKKAEEAGASAAACEAPSAAGPGAP 290
Query: 257 ARQDEGKEEEPEA 269
Q+ EEP A
Sbjct: 291 PEQEAAPAEEPAA 303
Score = 45.1 bits (105), Expect = 7e-05
Identities = 47/151 (31%), Positives = 66/151 (43%), Gaps = 27/151 (17%)
Query: 99 EAEANKKDEAPVADGVEK-----KGEGTTTAEAAPA---TGSKPDEPGKAGETPSEEKKG 150
EA A + EA VA K G +A+PA +G+K +E G P+ +K+
Sbjct: 13 EAAAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAK-EELQANGSAPAADKEE 71
Query: 151 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEE------PKQA 204
A + A+P A E A +A A SP K +APA+ E P A
Sbjct: 72 PAAAGSGAASPSAAEKGEPAAAAAPEAGA-------SPVEK--EAPAEGEAAEPGSPTAA 122
Query: 205 DVPAAVTAAAATTPAAEDAAAKATAQPPTET 235
+ AA A++ ++P AED AT P ET
Sbjct: 123 EGEAASAASSTSSPKAEDG---ATPSPSNET 150
Score = 41.6 bits (96), Expect = 8e-04
Identities = 35/134 (26%), Positives = 56/134 (41%), Gaps = 17/134 (12%)
Query: 117 KGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATE----------QAAPQAPAS 166
KGE A P + P KA + K GDA+ QA APA+
Sbjct: 11 KGEA---AAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAESGAKEELQANGSAPAA 67
Query: 167 SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAED---- 222
+E+ +A + +A+ ++ + + A A P + + PA AA +P A +
Sbjct: 68 DKEEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEGEAA 127
Query: 223 AAAKATAQPPTETG 236
+AA +T+ P E G
Sbjct: 128 SAASSTSSPKAEDG 141
Score = 37.7 bits (86), Expect = 0.011
Identities = 42/139 (30%), Positives = 54/139 (38%), Gaps = 25/139 (17%)
Query: 151 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAE----------DAPA--K 198
+G+AA E+ A ASS KA E K + D SP++ APA K
Sbjct: 11 KGEAAAERPGEAAVASSPSKANGQEN-GHVKVNGDASPAAAESGAKEELQANGSAPAADK 69
Query: 199 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQP----------PTETGESSQAEENIEAV 248
EEP A AA +AA A AA +A A P E G + AE EA
Sbjct: 70 EEPAAAGSGAASPSAAEKGEPAAAAAPEAGASPVEKEAPAEGEAAEPGSPTAAEG--EAA 127
Query: 249 DETKPKESARQDEGKEEEP 267
S + ++G P
Sbjct: 128 SAASSTSSPKAEDGATPSP 146
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 60.5 bits (145), Expect = 2e-09
Identities = 56/232 (24%), Positives = 97/232 (41%), Gaps = 28/232 (12%)
Query: 47 VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 106
VE+ ++ K+E + + E+ ++ S +K EKK+ A +K+
Sbjct: 453 VEEIIEETKVEDEKSEMEEALTAITEELAVS---------MKEEKKE-------AAEEKE 496
Query: 107 EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA-APQAPA 165
E P A+ E A+ +P + P+ + GE EE + E + E A + QA
Sbjct: 497 EEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 550
Query: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT-----AAAATTPAA 220
EK GS+E E + + ++ E+A AKEE K + V A A
Sbjct: 551 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 610
Query: 221 EDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 272
E A + P E G+S + +E ++ +S +++GK P++ E
Sbjct: 611 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 662
Score = 49.7 bits (117), Expect = 3e-06
Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 31/241 (12%)
Query: 49 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 108
K + + E+ +PE + + A K K+ +GEK+++ + E ++DE
Sbjct: 485 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEG 542
Query: 109 PVAD-----GVEKKG----------EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 153
+D G EK+G EG T AEA E +A E E+K E
Sbjct: 543 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-------GEEAEAKEEKKVEEKSEEV 595
Query: 154 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAA 213
A E+ A EKA S K+ + S +P +E+ K + VP +
Sbjct: 596 ATKEELVADAKVEKPEKAKS----PVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEE 650
Query: 214 AATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKESARQDEGKEEEPEADQ 271
+P + + P +++ +A+ + V+E K K + E KEEE + +
Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710
Query: 272 E 272
E
Sbjct: 711 E 711
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/216 (23%), Positives = 79/216 (36%), Gaps = 35/216 (16%)
Query: 53 DQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD 112
D K+E KPE KA K +G K E+K ++ +K ++PV
Sbjct: 604 DAKVE----KPE-KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 658
Query: 113 G-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKA 171
VE+KG+ + P E S+ + G+G+ E+ A EEK
Sbjct: 659 SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 718
Query: 172 GSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAK-ATAQ 230
E K +D P K++ A +P E+A A+ T
Sbjct: 719 EKKE--------------EKPKDVPEKKK--------------AESPVKEEAVAEVVTIT 750
Query: 231 PPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 266
+ + +E + + + K KE A + G EEE
Sbjct: 751 KSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 786
Score = 30.8 bits (68), Expect = 1.3
Identities = 39/153 (25%), Positives = 65/153 (42%), Gaps = 18/153 (11%)
Query: 51 DDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPV 110
+ + K E ++ E + KA + + G + K KG +K+D+ A E K+E V
Sbjct: 758 EKETKEEGKPLQQEKEKEKAGGEGGSEEEG--SDKGAKGSRKEDI-AVNGEVEGKEE--V 812
Query: 111 ADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEK 170
++KG G + G +P++EKKG GD + E+ + EK
Sbjct: 813 EQETKEKGSGREEEKGVVTNG--------LDLSPADEKKG-GDKSEEKV---VVTKTVEK 860
Query: 171 AGSAETESATKASTDN-SPSSKAEDAPAKEEPK 202
S + ATK T + + + K E+ E K
Sbjct: 861 ITSEGGDGATKYITKSVTVTQKVEEHEETFEEK 893
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 60.5 bits (145), Expect = 2e-09
Identities = 56/232 (24%), Positives = 97/232 (41%), Gaps = 28/232 (12%)
Query: 47 VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 106
VE+ ++ K+E + + E+ ++ S +K EKK+ A +K+
Sbjct: 77 VEEIIEETKVEDEKSEMEEALTAITEELAVS---------MKEEKKE-------AAEEKE 120
Query: 107 EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA-APQAPA 165
E P A+ E A+ +P + P+ + GE EE + E + E A + QA
Sbjct: 121 EEPEAE------EEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEE 174
Query: 166 SSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT-----AAAATTPAA 220
EK GS+E E + + ++ E+A AKEE K + V A A
Sbjct: 175 GGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKP 234
Query: 221 EDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 272
E A + P E G+S + +E ++ +S +++GK P++ E
Sbjct: 235 EKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVE 286
Score = 49.7 bits (117), Expect = 3e-06
Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 31/241 (12%)
Query: 49 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 108
K + + E+ +PE + + A K K+ +GEK+++ + E ++DE
Sbjct: 109 KEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEE--EGQEEEEEEDEG 166
Query: 109 PVAD-----GVEKKG----------EGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 153
+D G EK+G EG T AEA E +A E E+K E
Sbjct: 167 AKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAE-------GEEAEAKEEKKVEEKSEEV 219
Query: 154 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAA 213
A E+ A EKA S K+ + S +P +E+ K + VP +
Sbjct: 220 ATKEELVADAKVEKPEKAKS----PVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEE 274
Query: 214 AATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKESARQDEGKEEEPEADQ 271
+P + + P +++ +A+ + V+E K K + E KEEE + +
Sbjct: 275 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 334
Query: 272 E 272
E
Sbjct: 335 E 335
Score = 44.3 bits (103), Expect = 1e-04
Identities = 50/216 (23%), Positives = 79/216 (36%), Gaps = 35/216 (16%)
Query: 53 DQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD 112
D K+E KPE KA K +G K E+K ++ +K ++PV
Sbjct: 228 DAKVE----KPE-KAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPK 282
Query: 113 G-VEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKA 171
VE+KG+ + P E S+ + G+G+ E+ A EEK
Sbjct: 283 SPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKV 342
Query: 172 GSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAK-ATAQ 230
E K +D P K++ A +P E+A A+ T
Sbjct: 343 EKKE--------------EKPKDVPEKKK--------------AESPVKEEAVAEVVTIT 374
Query: 231 PPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 266
+ + +E + + + K KE A + G EEE
Sbjct: 375 KSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEE 410
Score = 30.8 bits (68), Expect = 1.3
Identities = 39/153 (25%), Positives = 65/153 (42%), Gaps = 18/153 (11%)
Query: 51 DDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPV 110
+ + K E ++ E + KA + + G + K KG +K+D+ A E K+E V
Sbjct: 382 EKETKEEGKPLQQEKEKEKAGGEGGSEEEG--SDKGAKGSRKEDI-AVNGEVEGKEE--V 436
Query: 111 ADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEK 170
++KG G + G +P++EKKG GD + E+ + EK
Sbjct: 437 EQETKEKGSGREEEKGVVTNG--------LDLSPADEKKG-GDKSEEKV---VVTKTVEK 484
Query: 171 AGSAETESATKASTDN-SPSSKAEDAPAKEEPK 202
S + ATK T + + + K E+ E K
Sbjct: 485 ITSEGGDGATKYITKSVTVTQKVEEHEETFEEK 517
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 60.1 bits (144), Expect = 2e-09
Identities = 61/231 (26%), Positives = 103/231 (44%), Gaps = 13/231 (5%)
Query: 48 EKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEANKKD 106
E +++ K E+ G + E + + TK + K+ K K++ ++ AEA++ +K+
Sbjct: 477 EAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKE 536
Query: 107 EA--PVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG--DAATEQAAPQ 162
EA P +K + EA +K E +A ++P+E K E A E+A
Sbjct: 537 EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEA-KSPAEVKSPEKAKSPAKEEAKSP 595
Query: 163 APASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-EEPKQADVPA---AVTAAAATTP 218
A A S EKA S E A + SP + +PA+ + P++A P A + A +P
Sbjct: 596 AEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP 655
Query: 219 AAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR---QDEGKEEE 266
E+A + A+ P + S + E K E A+ ++E K E
Sbjct: 656 EKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPE 706
Score = 59.7 bits (143), Expect = 3e-09
Identities = 53/224 (23%), Positives = 95/224 (42%), Gaps = 15/224 (6%)
Query: 58 QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKK 117
++ IK +K+ K ++ +++ E++ + + E + + E A+G E++
Sbjct: 441 EEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEE 500
Query: 118 GEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE 177
+ EAA + ++P+E K E E+A A S EKA S E
Sbjct: 501 TKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE----KEEAKSPAEVKSPEKAKSPAKE 556
Query: 178 SATKASTDNSPSSKAEDAPAK-EEPKQADVPA---------AVTAAAATTPAAEDAAAKA 227
A SP + +PA+ + P++A PA A + A +P E+A + A
Sbjct: 557 EAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPA 616
Query: 228 TAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 271
A+ P + S AE ++ KE A+ E K + PE ++
Sbjct: 617 EAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPE-KAKSPEKEE 659
Score = 56.6 bits (135), Expect = 2e-08
Identities = 57/225 (25%), Positives = 88/225 (39%), Gaps = 17/225 (7%)
Query: 61 IKPEDKA-HKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA-PVADGVEKKG 118
+K E K KA + ++ + K + K DV++ EA+ K+EA AD +K
Sbjct: 726 VKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKA 785
Query: 119 EGTTTAEA-APATGSKP-DEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAET 176
+ E +P P E KA E +K+ E+ PQ E + E
Sbjct: 786 KSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEE 845
Query: 177 ESATKASTDNSPSSKAEDAPAKEEPK----QADVPAAVTAAAATTPAAEDAAAKATAQPP 232
++ T+ SK E+AP KE PK + PA + A ++ A P
Sbjct: 846 KAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPT 905
Query: 233 TETGESSQAEENIEAVDETKPKESA-----RQDEGKEEEPEADQE 272
E +A +E ++ KPKE D+ K +EP E
Sbjct: 906 PE----KEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAE 946
Score = 55.8 bits (133), Expect = 4e-08
Identities = 58/229 (25%), Positives = 97/229 (42%), Gaps = 27/229 (11%)
Query: 57 EQDGIKPEDK-AHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVE 115
+++ P DK KA + ++ + + +K K K+D +A E E KK+E E
Sbjct: 771 KEEARSPADKFPEKAKSPVKEEVK---SPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEE 827
Query: 116 KKGEGTTTAE-----------AAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAP 164
+K + E A P T K D K E P +E ++ A + P
Sbjct: 828 EKPQEVKVKEPPKKAEEEKAPATPKTEEKKDS--KKEEAPKKEAPKPKVEEKKEPAVEKP 885
Query: 165 ASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAA 224
S+ +A E E K T ++APAK E K+ P T A P +DA
Sbjct: 886 KESKVEAKKEEAEDKKKVPTPE------KEAPAKVEVKEDAKPKEKTEVAKKEP--DDAK 937
Query: 225 AKATAQPPTETGESSQAEENIEAVDETKPKESARQD-EGKEEEPEADQE 272
AK ++ P E E++ +++ + KP+E + + + KE++ +E
Sbjct: 938 AKEPSK-PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985
Score = 53.9 bits (128), Expect = 1e-07
Identities = 53/194 (27%), Positives = 86/194 (44%), Gaps = 16/194 (8%)
Query: 83 TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKP--DEPGKA 140
T K+K E+K V K ++ V VE++ E T E K +E GK
Sbjct: 434 THIKVKSEEKIKV------VEKSEKETVI--VEEQTEETQVTEEVTEEEEKEAKEEEGKE 485
Query: 141 GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-E 199
E EE+ G+ T+ + AS E++A S E A + SP + +PA+ +
Sbjct: 486 EEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVK 545
Query: 200 EPKQADVPA---AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 256
P++A PA A + A +P E+A + A + P + S A+E ++ E K E
Sbjct: 546 SPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKA--KSPAKEEAKSPAEAKSPEK 603
Query: 257 ARQDEGKEEEPEAD 270
A+ +E + A+
Sbjct: 604 AKSPVKEEAKSPAE 617
Score = 53.5 bits (127), Expect = 2e-07
Identities = 53/229 (23%), Positives = 104/229 (45%), Gaps = 15/229 (6%)
Query: 54 QKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDE----AP 109
+K E++ + E++ + + + K+ +G++++ + EAE +++ A
Sbjct: 448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAE 507
Query: 110 VADGVEKKGEGTTTAEA-APATGSKPD--EPGKAGETPSEEKKGEGDAATEQAAPQAPAS 166
A EK+ + EA +PA P+ E E S EK ++ P+A +
Sbjct: 508 EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP 567
Query: 167 SEEKAGS-AETESATKASTDNSPSSKAEDAPAK-EEPKQADVPA---AVTAAAATTPAAE 221
+E+A S AE +S KA SP+ + +PA+ + P++A P A + A A +P E
Sbjct: 568 EKEEAKSPAEVKSPEKAK---SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 222 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEAD 270
+A + A + P + ++ E ++ KE A+ E + +A+
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAE 673
Score = 52.8 bits (125), Expect = 3e-07
Identities = 50/222 (22%), Positives = 98/222 (44%), Gaps = 19/222 (8%)
Query: 52 DDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEANKKDEAPV 110
++ K + PE + K+ ++++ +K K K++ ++ AEA++ +K ++PV
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSP-------EKAKSPAKEEAKSPAEAKSPEKAKSPV 608
Query: 111 ADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEK 170
+ + E + + + ++ P KA EE K A + + + A S EK
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPE---KEEAKSPEK 665
Query: 171 AGS---AETESATKASTDNSPSSKAED---APAKEEPKQADVPAAVTAAAATTPAAEDAA 224
A S AE +S KA + +K+ + +P KEE K + + A +P +
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSP 725
Query: 225 AKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 266
K A+ P + S +E ++ ++ K E A+ + K E
Sbjct: 726 VKEEAKTPEKA--KSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765
Score = 50.4 bits (119), Expect = 2e-06
Identities = 46/197 (23%), Positives = 76/197 (38%), Gaps = 20/197 (10%)
Query: 90 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKK 149
EK++ AE ++ +K ++P + + E + +A + P +A EE K
Sbjct: 568 EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAK 627
Query: 150 GEGDAATEQAAP---QAPASSEEKAGSAETESATKASTDNSP------SSKAEDAPAKEE 200
+ + + A + A S EKA S E E A SP S + +P K E
Sbjct: 628 SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687
Query: 201 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR-- 258
K + A +P E+A + A+ P + S + +E K E A+
Sbjct: 688 AKSPE--------KAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSP 739
Query: 259 -QDEGKEEEPEADQEHA 274
++E K E E A
Sbjct: 740 VKEEAKSPEKAKSPEKA 756
Score = 49.7 bits (117), Expect = 3e-06
Identities = 58/212 (27%), Positives = 92/212 (43%), Gaps = 12/212 (5%)
Query: 61 IKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQA-AEAEANKKDEA--PVADGVEKK 117
+K +KA A + S + +K K K++ ++ AEA++ K+EA P +K
Sbjct: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637
Query: 118 GEGTTTAEA-APATGSKPD-EPGKAGETPSEEKKGEGDAATEQAAP-QAPASSEEKAGSA 174
+ T EA +P P+ E K+ E K E + + +P +A A S EKA S
Sbjct: 638 AKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSP 697
Query: 175 ETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTE 234
E A S + + S E+A + E+ K A T A +P E+A + A+ P
Sbjct: 698 VKEEA--KSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSP-- 753
Query: 235 TGESSQAEENIEAVDETKPKESARQDEGKEEE 266
E ++ + +T KE AR K E
Sbjct: 754 --EKAKTLDVKSPEAKTPAKEEARSPADKFPE 783
Score = 48.1 bits (113), Expect = 8e-06
Identities = 63/259 (24%), Positives = 98/259 (37%), Gaps = 41/259 (15%)
Query: 52 DDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVA 111
++ K + PE + K+ K ++ + EK AEA++ +K ++PV
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP----EKAKSPVKAEAKSPEKAKSPVK 699
Query: 112 DGVEK--------KGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA--- 160
+ + K E + +A + P KA EE K A + + A
Sbjct: 700 EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTL 759
Query: 161 ----PQA--PASSE---------EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQAD 205
P+A PA E EKA S E SP + AP KE PK+ +
Sbjct: 760 DVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEE 819
Query: 206 VPAAV------TAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
V + V P + KA A P TE + S+ EE + KPK ++
Sbjct: 820 VKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEE-APKKEAPKPKVEEKK 878
Query: 260 ----DEGKEEEPEADQEHA 274
++ KE + EA +E A
Sbjct: 879 EPAVEKPKESKVEAKKEEA 897
Score = 48.1 bits (113), Expect = 8e-06
Identities = 47/185 (25%), Positives = 78/185 (42%), Gaps = 17/185 (9%)
Query: 85 KKLKGEKKDDV-QAAEAEANKKDEAPVADG----VEKKGEGTTTAEAAPATGSKPDEPGK 139
KK + EK + E + +KK+EAP + VE+K E +K +E
Sbjct: 840 KKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED 899
Query: 140 AGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE-SATKASTDNSPSSKAEDAPAK 198
+ P+ EK+ A + + A +EK A+ E KA + P+ K E AP K
Sbjct: 900 KKKVPTPEKE-----APAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEK 954
Query: 199 EEPKQ--ADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 256
++ K+ A P A + +K ++P E E S + + ++KP E
Sbjct: 955 KDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQ----KDSKPPEK 1010
Query: 257 ARQDE 261
A +D+
Sbjct: 1011 ATEDK 1015
Score = 47.0 bits (110), Expect = 2e-05
Identities = 48/196 (24%), Positives = 86/196 (43%), Gaps = 17/196 (8%)
Query: 85 KKLKGEKKDDVQAAE-AEANKKDEAPVADGVEK--KGEGTTTAEAAPATGSKPDEPGKAG 141
+K K K++ ++ E A++ +K+EA + + K E + +A ++ P KA
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695
Query: 142 ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEP 201
EE K A ++ + A S EKA S E A SP + +P K +
Sbjct: 696 SPVKEEAKSPEKA---KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKS 752
Query: 202 KQADVPAAVTAAAATTPAAEDA---------AAKATAQPPTETGESSQA--EENIEAVDE 250
+ V + A TPA E+A AK+ + ++ E +++ +E+ +A ++
Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEK 812
Query: 251 TKPKESARQDEGKEEE 266
PK+ + KEEE
Sbjct: 813 EIPKKEEVKSPVKEEE 828
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 57.4 bits (137), Expect = 1e-08
Identities = 45/231 (19%), Positives = 94/231 (40%), Gaps = 10/231 (4%)
Query: 48 EKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDE 107
++ ++D K E+ G +++ + K G+ + K + +KK++ + AEA+ + E
Sbjct: 4787 DEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGE 4846
Query: 108 APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP------SEEKKGEGDAATEQAAP 161
+ + ++++ + K EP +A + P SE+K G D E+
Sbjct: 4847 DKINEQIDERDYDENEVDPYHGNQEKVPEP-EALDLPDDLNLDSEDKNGGEDTDNEEGEE 4905
Query: 162 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 221
+ P +EK A E+ + T+ + +E P + D A+
Sbjct: 4906 ENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDD---KAEGEEEMDTGAD 4962
Query: 222 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 272
D A P + E Q+ E + + + E+ D+G + + E ++E
Sbjct: 4963 DQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEERE 5013
Score = 40.8 bits (94), Expect = 0.001
Identities = 42/184 (22%), Positives = 71/184 (38%), Gaps = 24/184 (13%)
Query: 89 GEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK 148
GE D+ + E + E P G E + G T E P EP E PSE+
Sbjct: 4895 GEDTDNEEGEEENPLEIKEKPEEAGHEAEERGET--ETDQNESQSPQEPE---EGPSEDD 4949
Query: 149 KGEGDAATEQAA----------PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK 198
K EG+ + A P+ + ++++ + + A + +N P+ + +
Sbjct: 4950 KAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQGFQPQEE 5009
Query: 199 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 258
EE + +D V A E + Q E +++QA E A E KE +
Sbjct: 5010 EEREDSDTEEQV------PEALERKEHASCGQTGVENMQNTQAMELAGAAPE---KEQGK 5060
Query: 259 QDEG 262
++ G
Sbjct: 5061 EEHG 5064
Score = 37.7 bits (86), Expect = 0.011
Identities = 45/221 (20%), Positives = 87/221 (39%), Gaps = 20/221 (9%)
Query: 48 EKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDE 107
E+ +D EQ E K H + + + +L G + Q E + +
Sbjct: 5010 EEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAAD 5069
Query: 108 APVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASS 167
A A+G E A+ A ++ + T S ++K G A E++
Sbjct: 5070 ANQAEG----HESNFIAQLASQKHTRKN-------TQSFKRK-PGQADNERSMGDHNERV 5117
Query: 168 EEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKA 227
++ + +T+S + P ++ EDA A E KQ + A D A+K
Sbjct: 5118 HKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQ--------GSDAYDAQTYDVASKE 5169
Query: 228 TAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 268
Q ++G+ + EE + + +T+ +E + + ++ +PE
Sbjct: 5170 QQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPE 5210
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 56.2 bits (134), Expect = 3e-08
Identities = 48/185 (25%), Positives = 79/185 (42%), Gaps = 12/185 (6%)
Query: 101 EANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 160
E+ K+++AP DG+ + +G S+ + GK + +E KK +G+
Sbjct: 67 ESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKE-DAEAELKKEDGEKEETTVG 125
Query: 161 PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ------ADVP---AAVT 211
Q +E+ S E+ K ST S KAE+ AK E Q D P A V
Sbjct: 126 SQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVE 185
Query: 212 AAAATTPAAEDAAAK--ATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 269
A T + E+ + + +P + + E+ +AV E + K ++ +GKEE
Sbjct: 186 EEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHG 245
Query: 270 DQEHA 274
+E A
Sbjct: 246 AKEEA 250
Score = 50.4 bits (119), Expect = 2e-06
Identities = 53/219 (24%), Positives = 81/219 (36%), Gaps = 43/219 (19%)
Query: 85 KKLKGEKKDDVQAA-EAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE------- 136
K+ K +D + A + EAN DE V E G+ AE G K +
Sbjct: 70 KQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETTVGSQEM 129
Query: 137 PGKAGETPSEEKKGEGDAAT--------------------------EQAAPQAPASSEEK 170
G+ ET SE K+ E +T ++ P+A E+
Sbjct: 130 TGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKATVEEEDA 189
Query: 171 AGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 230
+++ E+ + P KA D AK E ++A V A E+A A
Sbjct: 190 KTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAK-- 247
Query: 231 PPTETGESSQAEENIEAVDETKP-KESARQDEGKEEEPE 268
E + A+E E +E +P S Q++ E+EPE
Sbjct: 248 ------EEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPE 280
Score = 47.8 bits (112), Expect = 1e-05
Identities = 46/195 (23%), Positives = 79/195 (40%), Gaps = 21/195 (10%)
Query: 85 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 144
KK GEK++ ++ +K+E ++ E T +E KA E
Sbjct: 113 KKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQ-----------KAEEKE 161
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAG--SAETESATKASTDNSPSSKAEDAPAKEEPK 202
++ + G+ A ++ P+ A+ EE+ +++ E+ + P KA D AK E +
Sbjct: 162 AKPESGQKADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQ 221
Query: 203 QADVPAAVTAAA--------ATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPK 254
+A V A A A E+A AK A+ E S +EE + V++
Sbjct: 222 KAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEG 281
Query: 255 ESARQDEGKEEEPEA 269
+ EE PE+
Sbjct: 282 GAGVIPSSPEEWPES 296
Score = 47.0 bits (110), Expect = 2e-05
Identities = 52/220 (23%), Positives = 81/220 (36%), Gaps = 30/220 (13%)
Query: 80 GHITRKKLKGEKKDDVQAAEAEANKKDE--APVADGVEKKGEGTTTAEAAPATGSK---- 133
G + E ++ ++ E + ++ +P AD E G G E G
Sbjct: 4 GAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINEG 63
Query: 134 -PDEPGKAGETPSE-----EKKGEGDAATE-------QAAPQAPASSEEKAGSAETESAT 180
P E GK + P+E E +GE + E +A + A +E K E E T
Sbjct: 64 PPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEETT 123
Query: 181 KASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ-----PPTET 235
S + + + + KE ++ A+ A A ++ KA A P T
Sbjct: 124 VGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKAT 183
Query: 236 GE------SSQAEENIEAVDETKPKESARQDEGKEEEPEA 269
E +SQ E T+PKE A +E K E +A
Sbjct: 184 VEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKA 223
Score = 43.5 bits (101), Expect = 2e-04
Identities = 56/228 (24%), Positives = 87/228 (38%), Gaps = 21/228 (9%)
Query: 57 EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKD--DVQAAEAEANKKDEAPVADGV 114
E G K E K+ + + S + +K K E+K+ +A+AN +D+ V
Sbjct: 128 EMTGRKEETKSEPKEAEEKEST---LASEKQKAEEKEAKPESGQKADANDRDKPEPKATV 184
Query: 115 EKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAAT----EQAAPQAPASSEEK 170
E++ T + E EP + + EE K E A +A P+ P EE
Sbjct: 185 EEEDAKTASQEETGQRKECSTEPKE--KATDEEAKAESQKAVVEDEAKAEPKEPDGKEEA 242
Query: 171 AGSAETESATKASTDN-------SPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 223
A+ E+ K ++ SPS + E KE A V + +P E
Sbjct: 243 KHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTGEGH 302
Query: 224 AAKATAQPP--TETGESS-QAEENIEAVDETKPKESARQDEGKEEEPE 268
P +G++S A E+ + P ES E KE+ PE
Sbjct: 303 NLSTDGLGPDCVASGQTSPSASESSPSDVPQSPPESPSSGEKKEKAPE 350
Score = 40.4 bits (93), Expect = 0.002
Identities = 43/174 (24%), Positives = 65/174 (37%), Gaps = 7/174 (4%)
Query: 51 DDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPV 110
D++ K E ED+A + K+ K++ A EAE E
Sbjct: 213 DEEAKAESQKAVVEDEAKAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQE 272
Query: 111 ADGVEKKGEGTTTAEAAPATGSK-PDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEE 169
D VEK+ EG A P++ + P+ P G S + G A+ Q +P A SS
Sbjct: 273 QD-VEKEPEGG--AGVIPSSPEEWPESPTGEGHNLSTDGLGPDCVASGQTSPSASESSPS 329
Query: 170 KAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVT---AAAATTPAA 220
+ ES + + APA+ +A A+ AA+ P A
Sbjct: 330 DVPQSPPESPSSGEKKEKAPERRVSAPARPRGPRAQNRKAIVDKFGGAASGPTA 383
Score = 36.6 bits (83), Expect = 0.024
Identities = 34/124 (27%), Positives = 51/124 (41%), Gaps = 16/124 (12%)
Query: 150 GEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAA 209
GE D + E A E+K G + T + ++P APA+E A A
Sbjct: 7 GESDCSAE-----AREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAG--KA 59
Query: 210 VTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEE-EPE 268
+ T ++ A P E G S++ + +DE K ES R+ GKE+ E E
Sbjct: 60 INEGPPTESGKQEKA-------PAEDGMSAELQGEANGLDEVK-VESQREAGGKEDAEAE 111
Query: 269 ADQE 272
+E
Sbjct: 112 LKKE 115
>gi|117938759 GNAS complex locus XLas [Homo sapiens]
Length = 1037
Score = 55.5 bits (132), Expect = 5e-08
Identities = 63/229 (27%), Positives = 81/229 (35%), Gaps = 15/229 (6%)
Query: 34 PYSLGFLTFWISRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKD 93
P+ +G + N D I DG P K A K + + R + + + E
Sbjct: 308 PFEIGSAPAGVDDTPVNMDSPPIALDG--PPIKVSGAPDKRERAERPPVEEEAAEMEGAA 365
Query: 94 DVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGD 153
D AE K T A AAPA + PD +G TP + G
Sbjct: 366 DA----AEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPD----SGATPEDPDSGTAP 417
Query: 154 AATEQAAPQA-PASSEEKAGSAETESATKASTDNSPSS-KAEDAPAKEEPKQADVPAAVT 211
A + A A P S A A+ +S P S A DAPA +P P A
Sbjct: 418 ADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPA--DPDAGAAPEAPA 475
Query: 212 A-AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
A AAA T AA A A A PT S+ + P AR+
Sbjct: 476 APAAAETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARR 524
Score = 44.3 bits (103), Expect = 1e-04
Identities = 46/178 (25%), Positives = 67/178 (37%), Gaps = 27/178 (15%)
Query: 89 GEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK 148
G +D + A A+ A AD A A P +G+ PD P + +
Sbjct: 405 GATPEDPDSGTAPADPDSGAFAAD---PDSGAAPAAPADPDSGAAPDAPADPDSGAAPDA 461
Query: 149 KGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA 208
+ DA AP APA++E +A +P + A APA + A V
Sbjct: 462 PADPDAGAAPEAPAAPAAAETRAAHV---------APAAPDAGAPTAPAASATRAAQVRR 512
Query: 209 AVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES-ARQDEGKEE 265
A +AA A+ A K +PP+ I+A D P+ + A GK E
Sbjct: 513 AASAAPAS-----GARRKIHLRPPS---------PEIQAADPPTPRPTRASAWRGKSE 556
Score = 37.0 bits (84), Expect = 0.019
Identities = 33/139 (23%), Positives = 53/139 (38%), Gaps = 9/139 (6%)
Query: 134 PDEPGKAGETPSEEKKGEGDAATEQAAP---QAPASSEEKAGSAETESATKASTDNSPSS 190
PD+ +A P EE+ E + A + A +P AG+A ++A +A+ + +
Sbjct: 343 PDKRERAERPPVEEEAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAP--AAPA 400
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDE 250
+ E+P PA + A AA A A P + + A+ + A
Sbjct: 401 DPDSGATPEDPDSGTAPADPDSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAA-- 458
Query: 251 TKPKESARQDEGKEEEPEA 269
P A D G E A
Sbjct: 459 --PDAPADPDAGAAPEAPA 475
Score = 36.6 bits (83), Expect = 0.024
Identities = 41/156 (26%), Positives = 55/156 (35%), Gaps = 11/156 (7%)
Query: 125 EAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST 184
EAA G+ G +P G A+ + AA APA+ + A E +
Sbjct: 357 EAAEMEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTA 416
Query: 185 DNSPSSKAEDAPAKEEPKQADVPAAV----TAAAATTPAAEDAAAKATAQPPTETGESSQ 240
P S A A +P PAA + AA PA D+ A A + G + +
Sbjct: 417 PADPDSGAFAA----DPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPE 472
Query: 241 AEENIEAVDETKPKE--SARQDEGKEEEPEADQEHA 274
A A ET+ A D G P A A
Sbjct: 473 APA-APAAAETRAAHVAPAAPDAGAPTAPAASATRA 507
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 55.1 bits (131), Expect = 7e-08
Identities = 57/236 (24%), Positives = 88/236 (37%), Gaps = 29/236 (12%)
Query: 48 EKNDDDQKIE--QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK 105
+ +++DQK + Q G+KP+ KA KA K K K D ++E E K
Sbjct: 135 DDDEEDQKKQPVQKGVKPQAKAAKAPPK------------KAKSSDSDSDSSSEDEP-PK 181
Query: 106 DEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEG-DAATEQAAPQAP 164
++ P V K + T A PA + GKA + S D + E+ A P
Sbjct: 182 NQKPKITPVTVKAQ--TKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATP 239
Query: 165 ASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ-----------ADVPAAVTAA 213
+ K A+T SS +ED+ + EE +Q + VP
Sbjct: 240 KKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPP 299
Query: 214 AATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 269
+ + Q P E+ E S E + + +E KP A + + P A
Sbjct: 300 PKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPA 355
Score = 53.1 bits (126), Expect = 3e-07
Identities = 54/238 (22%), Positives = 86/238 (36%), Gaps = 30/238 (12%)
Query: 45 SRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 104
S + DD + E+ P+ K +A + T + K +D + E E K
Sbjct: 221 SSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTR-KSSSSEDSSSDEEEEQK 279
Query: 105 K----------DEAPVADGVEKKGEGTT----TAEAAPATGSKPDEPGKAGETPSEEKKG 150
K P + KK GT E S D ++ + EEKK
Sbjct: 280 KPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKP 339
Query: 151 EGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAV 210
A +A + P + + S+++ + + D +PS PA ++ PA
Sbjct: 340 PTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK-----PAGTTKNSSNKPAVT 394
Query: 211 TAAAATTPAAED----------AAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 258
T + A PAA KA + E SS+ E+ + V TKPK +A+
Sbjct: 395 TKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAK 452
Score = 50.4 bits (119), Expect = 2e-06
Identities = 58/263 (22%), Positives = 111/263 (42%), Gaps = 44/263 (16%)
Query: 45 SRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 104
S + D ++ E+ P KA A ++ G K + ++ + E ++
Sbjct: 83 SSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLP-PGKAAAKASESSSSEESSDDDDEEDQ 141
Query: 105 KDEAPVADGVEKKGEGTTTAEAAP--ATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQ 162
K + PV GV+ + + A+A P A S D + + P + +K + T +A +
Sbjct: 142 KKQ-PVQKGVKPQAKA---AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTK 197
Query: 163 APAS--------SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 214
AP + KA S+ + S++ +S+D+S KA P K PK+ V A A
Sbjct: 198 APPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKK-QVVAKAPVKA 256
Query: 215 ATTPAAEDAAAKATAQ-------------------------PPTETGESSQAEENIEAVD 249
ATTP + ++++ ++ PP + +Q + +AV+
Sbjct: 257 ATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPK--KAVE 314
Query: 250 ETKPKESARQDEGKEEEPEADQE 272
+ +P ES+ +D E + +++E
Sbjct: 315 KQQPVESS-EDSSDESDSSSEEE 336
Score = 45.8 bits (107), Expect = 4e-05
Identities = 48/224 (21%), Positives = 93/224 (41%), Gaps = 16/224 (7%)
Query: 49 KNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEA 108
++ +D E D E+K K TK S + K + ++++++++ DEA
Sbjct: 320 ESSEDSSDESDSSSEEEK--KPPTKAVVS-KATTKPPPAKKAAESSSDSSDSDSSEDDEA 376
Query: 109 PVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSE 168
P K GTT + + K P + G T +A +SSE
Sbjct: 377 P------SKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKA---DSSSSE 427
Query: 169 EKAGSAETESATKASTDNSPSSKAEDA---PAKEEPKQADVPAAVTAAAATTPAAEDAAA 225
E++ S+E E K P + A+ A PAK+ P+ + ++ + ++++ E +
Sbjct: 428 EESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSK 487
Query: 226 KATAQPPTE-TGESSQAEENIEAVDETKPKESARQDEGKEEEPE 268
A + P + G ++ ++ + + S+ D+ EEE E
Sbjct: 488 SAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEE 531
Score = 41.6 bits (96), Expect = 8e-04
Identities = 48/233 (20%), Positives = 91/233 (39%), Gaps = 19/233 (8%)
Query: 49 KNDDDQKIEQDGIKPEDKAHK--AATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKD 106
K D E+ E+K K A TK +A+ + ++ + A +A +D
Sbjct: 420 KADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALS-----------LPAKQAPQGSRD 468
Query: 107 EAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS 166
+ +D + E T+++A + G A P+ KKG+ +++ ++ +
Sbjct: 469 SSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEE 528
Query: 167 SEEK---AGSAETES--ATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 221
EEK GS ++ A S + + KA +EE ++ V+ + + +
Sbjct: 529 EEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQ 588
Query: 222 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
+ AAK A+ P Q + + + S+ +EEE E D A
Sbjct: 589 NEAAK-EAETPQAKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVDSRVA 640
Score = 37.4 bits (85), Expect = 0.014
Identities = 36/174 (20%), Positives = 61/174 (35%), Gaps = 7/174 (4%)
Query: 101 EANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAA 160
E + PVA +KK + + +++ P K P++ A +A+
Sbjct: 65 ERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKAS 124
Query: 161 PQAPASSEEKAGSAETESATKASTDNS--PSSKAEDAP---AKEEPKQADVPAAVTAAAA 215
+ SSEE + + E K P +KA AP AK +D +
Sbjct: 125 ESS--SSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKN 182
Query: 216 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEA 269
P KA + P + ++ N +A + S+ + EEE A
Sbjct: 183 QKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAA 236
Score = 30.4 bits (67), Expect = 1.7
Identities = 24/134 (17%), Positives = 53/134 (39%), Gaps = 8/134 (5%)
Query: 139 KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK 198
K+ + P + + G A + + + SE+ + E A P+ + P K
Sbjct: 59 KSAKVPERKLQANGPVAKKAKKKASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGK 118
Query: 199 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESAR 258
K ++ ++++ +++D + + P + G QA+ + K +S
Sbjct: 119 AAAKASE-------SSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDS-D 170
Query: 259 QDEGKEEEPEADQE 272
D E+EP +Q+
Sbjct: 171 SDSSSEDEPPKNQK 184
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 53.1 bits (126), Expect = 3e-07
Identities = 44/197 (22%), Positives = 74/197 (37%), Gaps = 15/197 (7%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKA----GET 143
+GE + + + E E ++ E +G E++GEG E G +E G+ GE
Sbjct: 890 EGEGEGEEEEGEGEGEEEGEG---EGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEG 946
Query: 144 PSEEKKGEGDAATEQAA----PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKE 199
EE++GE + E+ + EE G E E + + E+ E
Sbjct: 947 EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE 1006
Query: 200 EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGES----SQAEENIEAVDETKPKE 255
E + + E+ + + E GE + EEN +E + +E
Sbjct: 1007 EEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066
Query: 256 SARQDEGKEEEPEADQE 272
Q+ G+EE D E
Sbjct: 1067 GKYQETGEEENERQDGE 1083
Score = 51.6 bits (122), Expect = 7e-07
Identities = 52/234 (22%), Positives = 86/234 (36%), Gaps = 24/234 (10%)
Query: 48 EKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEAN---- 103
E+ + + K E +G + E + K + + R K+ KGE++ D E E
Sbjct: 749 EEKEGEGKEEGEGEEVEGEREKEEGERKKEERAG---KEEKGEEEGDQGEGEEEETEGRG 805
Query: 104 --KKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAP 161
K++ V G ++G+G E G + + G+ E EE++GEG E
Sbjct: 806 EEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEG 865
Query: 162 QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAE 221
+ EE G E E + E+ E ++ + E
Sbjct: 866 EGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGE------------GEGE 913
Query: 222 DAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD---EGKEEEPEADQE 272
+ + + E GE EE E E E ++ EG+EEE E + E
Sbjct: 914 EEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGE 967
Score = 50.1 bits (118), Expect = 2e-06
Identities = 40/185 (21%), Positives = 70/185 (37%), Gaps = 13/185 (7%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
+GE K + + E E ++ E +G E++GEG E G +E G+ E
Sbjct: 853 EGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEE---GEGEGEEEEGEG----EGE 905
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVP 207
++GEG+ E+ + EE G E E D + E+ + E ++ +
Sbjct: 906 EEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGE-- 963
Query: 208 AAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEP 267
E + + GE + E E +E + +E + +EEE
Sbjct: 964 ----GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEG 1019
Query: 268 EADQE 272
E + E
Sbjct: 1020 EVEGE 1024
Score = 49.7 bits (117), Expect = 3e-06
Identities = 51/223 (22%), Positives = 82/223 (36%), Gaps = 20/223 (8%)
Query: 57 EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEK 116
++DG + E K + +GH + + E+ + + E E + D + EK
Sbjct: 704 KRDGEEQEQKERE---------QGHQKERNQEMEEGGEEEHGEGEEEEGDRE---EEEEK 751
Query: 117 KGEGTTTAEAAPATGSKPDEPG--KAGETPSEEKKG--EGDAATEQAAPQAPASSEEKAG 172
+GEG E G + E G K E +E+KG EGD E + EEK
Sbjct: 752 EGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQG-EGEEEETEGRGEEKEE 810
Query: 173 SAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPP 232
E E + E+ +EE + + E+ + +
Sbjct: 811 GGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEE 870
Query: 233 TETGESSQAEENIEAVDETKPKESARQDEGK---EEEPEADQE 272
E GE EE E E + + ++EG+ EEE E + E
Sbjct: 871 GEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGE 913
Score = 49.7 bits (117), Expect = 3e-06
Identities = 48/237 (20%), Positives = 88/237 (37%), Gaps = 12/237 (5%)
Query: 48 EKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDE 107
E+ + ++ E +G + E + + + + G + +GE+ + E + +E
Sbjct: 830 EEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEE 889
Query: 108 APVADGVEKKGEGTTTAEA-----APATGSKPDEPGKAGETPSEEKKGEG---DAATEQA 159
+G E++GEG E K +E G+ GE EE++GEG D E
Sbjct: 890 EGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGE 949
Query: 160 APQAPASSEEKAGSAETESATKASTD----NSPSSKAEDAPAKEEPKQADVPAAVTAAAA 215
+ EE+ G E E + + + E +EE ++
Sbjct: 950 EEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEG 1009
Query: 216 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 272
E+ + + E GE EE E E + KE ++ + E E ++E
Sbjct: 1010 EGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066
Score = 45.1 bits (105), Expect = 7e-05
Identities = 42/189 (22%), Positives = 73/189 (38%), Gaps = 15/189 (7%)
Query: 85 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 144
KK GE+++ + + ++++ G E+ GEG G + +E K GE
Sbjct: 703 KKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEG------EEEEGDREEEEEKEGE-G 755
Query: 145 SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 204
EE +GE + E+ + EE+AG E + + E+ + ++
Sbjct: 756 KEEGEGE-EVEGEREKEEGERKKEERAGKEE------KGEEEGDQGEGEEEETEGRGEEK 808
Query: 205 DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAE-ENIEAVDETKPKESARQDEGK 263
+ V E + + E GE + E E E E K +E + EG+
Sbjct: 809 EEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGE 868
Query: 264 EEEPEADQE 272
EE E + E
Sbjct: 869 EEGEEGEGE 877
Score = 37.4 bits (85), Expect = 0.014
Identities = 45/190 (23%), Positives = 68/190 (35%), Gaps = 13/190 (6%)
Query: 87 LKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP-- 144
L + D + +E +A EA DG E +G+G T E + DE + GE
Sbjct: 626 LSDDLTDKAEVSEGKAKSVGEAE--DGPEGRGDG-TCEEGSSGAEHWQDEEREKGEKDKG 682
Query: 145 --SEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPK 202
E+ GEG+ + EE+ E E + + E+ + E +
Sbjct: 683 RGEMERPGEGEKELAEKEEWKKRDGEEQE-QKEREQGHQKERNQEMEEGGEEEHGEGEEE 741
Query: 203 QADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEG 262
+ D E + + E GE + E A E K +E Q EG
Sbjct: 742 EGDREEEEEKEGEGKEEGE--GEEVEGEREKEEGERKKEE---RAGKEEKGEEEGDQGEG 796
Query: 263 KEEEPEADQE 272
+EEE E E
Sbjct: 797 EEEETEGRGE 806
Score = 35.8 bits (81), Expect = 0.041
Identities = 32/155 (20%), Positives = 60/155 (38%), Gaps = 16/155 (10%)
Query: 57 EQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEK 116
E++G + + + + G + +GE++ + + E E ++E +G E+
Sbjct: 934 EEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEE 993
Query: 117 KGE--------GTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSE 168
+GE G E G + +E GE EE +GEG E+ +
Sbjct: 994 EGEEEGEEEGEG---EEEGEGEGEEEEEGEVEGEVEGEEGEGEG----EEEEGEEEGEER 1046
Query: 169 EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 203
EK G E E+ + K ++ +E +Q
Sbjct: 1047 EKEGEGE-ENRRNREEEEEEEGKYQETGEEENERQ 1080
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 53.1 bits (126), Expect = 3e-07
Identities = 53/195 (27%), Positives = 82/195 (42%), Gaps = 19/195 (9%)
Query: 61 IKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEG 120
+ E A +A ++Q+ T ++ E +Q A DE P A+ E
Sbjct: 495 LSEETSAEEAHAEVQSPLAEETTAEEASAE----IQLLAAIEAPADETP-AEAQSPLSE- 548
Query: 121 TTTAEAAPATGSKPDEPGKA-GETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESA 179
T+AE APA P G + E P E + G+ T +EE + + + +A
Sbjct: 549 ETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETT----------AEEASAAIQLLAA 598
Query: 180 TKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAKATAQPPTETGES 238
T+AS + +P+ + + PA+E P + P A A A P AE+A A+ P E
Sbjct: 599 TEASAEEAPA-EVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAE 657
Query: 239 SQAEENIEAVDETKP 253
Q EA E +P
Sbjct: 658 VQPPPAEEAPAEVQP 672
Score = 51.6 bits (122), Expect = 7e-07
Identities = 53/192 (27%), Positives = 86/192 (44%), Gaps = 18/192 (9%)
Query: 90 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPA-------TGSKPDEPGKAGE 142
E+ ++Q + A +EAP E TTAE A A T DE
Sbjct: 435 EEARELQLSTAMETPAEEAPTEFQSPLPKE--TTAEEASAEIQLLAATEPPADETPAEAR 492
Query: 143 TPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETE--SATKASTDNSPSSKAEDAPAKEE 200
+P E+ +A E +P A ++ E+A SAE + +A +A D +P+ +P EE
Sbjct: 493 SPLSEETSAEEAHAEVQSPLAEETTAEEA-SAEIQLLAAIEAPADETPAE--AQSPLSEE 549
Query: 201 PKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQD 260
+ PA V + +A + E+A + QPP +GE + AEE A+ E++ ++
Sbjct: 550 TSAEEAPAEVQSPSAKGVSIEEAPLE--LQPP--SGEETTAEEASAAIQLLAATEASAEE 605
Query: 261 EGKEEEPEADQE 272
E +P +E
Sbjct: 606 APAEVQPPPAEE 617
Score = 46.6 bits (109), Expect = 2e-05
Identities = 54/226 (23%), Positives = 93/226 (41%), Gaps = 12/226 (5%)
Query: 58 QDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDV--QAAEAEANKKDEAPVADGVE 115
Q + E A +A+ +IQ + E + + + + EA+ + ++P+A+
Sbjct: 458 QSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETT 517
Query: 116 KKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAG--- 172
+ E + + A + DE ++P E+ +A E +P A S E+A
Sbjct: 518 AE-EASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLEL 576
Query: 173 ---SAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA-AAATTPAAEDAAAKAT 228
S E +A +AS + A +A A+E P + P A A A P AE+A A+
Sbjct: 577 QPPSGEETTAEEASAAIQLLA-ATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQ 635
Query: 229 AQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
P E Q EA E +P A + + + P A++ A
Sbjct: 636 PPPAEEAPAEVQPPPAEEAPAEVQP-PPAEEAPAEVQPPPAEEAPA 680
Score = 39.7 bits (91), Expect = 0.003
Identities = 31/133 (23%), Positives = 57/133 (42%), Gaps = 9/133 (6%)
Query: 128 PATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNS 187
PA G+ + P K EE + + AP+ E+A + +A + + +
Sbjct: 400 PAEGALEEAPAKVEPPTVEETLADVQPLLPEEAPR------EEARELQLSTAMETPAEEA 453
Query: 188 PSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTET-GESSQAEENIE 246
P+ +P +E + A + AAT P A++ A+A + ET E + AE
Sbjct: 454 PTE--FQSPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSP 511
Query: 247 AVDETKPKESARQ 259
+ET +E++ +
Sbjct: 512 LAEETTAEEASAE 524
Score = 38.9 bits (89), Expect = 0.005
Identities = 37/153 (24%), Positives = 58/153 (37%), Gaps = 9/153 (5%)
Query: 98 AEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPD-EPGKAGETPSEEKKGEGDAAT 156
AE + +EAP E + PA + + +P A E P+E + + A
Sbjct: 608 AEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAP 667
Query: 157 EQAAP----QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA 212
+ P +APA + T A+ + P A+D PA+E P A
Sbjct: 668 AEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHSPP---ADDVPAEEASVDKHSPPADLL 724
Query: 213 AAATTPAAEDAAAKATAQPPTETGESSQAEENI 245
P E A+A+ + P +T E EN+
Sbjct: 725 LTEEFPIGE-ASAEVSPPPSEQTPEDEALVENV 756
Score = 33.5 bits (75), Expect = 0.21
Identities = 56/250 (22%), Positives = 95/250 (38%), Gaps = 38/250 (15%)
Query: 55 KIEQDGIKPEDKAHKAATKIQAS----FRGHITRKKLKGEKKDDVQAAEAEANKKDEAPV 110
K ++D +K HK++ KI AS F+ + G+K + E K +
Sbjct: 176 KSKEDALK-----HKSSGKIFASEHPEFQPATNSNEEIGQKNISRTSFTQETKKGPPVLL 230
Query: 111 ADGVEKKGEGTTTAE--AAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPAS-- 166
D + ++ E A S EP + P++ + + AT +A P+ PA
Sbjct: 231 EDELREEVTVPVVQEGSAVKKVASAEIEPPSTEKFPAKIQPPLVEEATAKAEPR-PAEET 289
Query: 167 ------SEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTA------AA 214
S E+ AE +A ++ AE+AP E P + P+A + A
Sbjct: 290 HVQVQPSTEETPDAEAATAVAENSVKVQPPPAEEAPLVEFPAEIQPPSAEESPSVELLAE 349
Query: 215 ATTPAAEDAAAK----ATAQPPTETGESSQAEENIEAVDETK--------PKESARQDEG 262
P+AE++ ++ PP E S + I + K P E A ++
Sbjct: 350 ILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPAEGALEEAP 409
Query: 263 KEEEPEADQE 272
+ EP +E
Sbjct: 410 AKVEPPTVEE 419
>gi|42518068 trans-golgi network protein 2 [Homo sapiens]
Length = 437
Score = 52.8 bits (125), Expect = 3e-07
Identities = 50/209 (23%), Positives = 81/209 (38%), Gaps = 28/209 (13%)
Query: 92 KDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGE 151
KD + AEA +++P G E K + + +++ + D P K+G K G
Sbjct: 134 KDSTGKSGAEAQTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGS 193
Query: 152 GDAATEQAAP-----------QAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAK-- 198
+ E P Q P K+G+ E S + ++D+P K
Sbjct: 194 SKSGAEDQTPKDVPNKSGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVV 253
Query: 199 -EEPKQAD--VPAAVTAAAATTPAAE--DAAAKATAQP---PTETGES----SQAEENI- 245
E+P + D P + + P A+ A K P TE+GE S +E +
Sbjct: 254 PEQPSRKDHSKPISNPSDNKELPKADTNQLADKGKLSPHAFKTESGEETDLISPPQEEVK 313
Query: 246 --EAVDETKPKESARQDEGKEEEPEADQE 272
E ++ +PKE+ D G EE +E
Sbjct: 314 SSEPTEDVEPKEAEDDDTGPEEGSPPKEE 342
Score = 46.2 bits (108), Expect = 3e-05
Identities = 62/262 (23%), Positives = 102/262 (38%), Gaps = 55/262 (20%)
Query: 55 KIEQDGIKPEDKAHKAATKIQASFR-GHITRKKLKGEK-KDDVQAAEAEANKKDEAPVAD 112
K E+ G++P A +T S R G T+ + + KD + AEA ++ P
Sbjct: 27 KQEEAGVRPS--AGNVSTHPSLSQRPGGSTKSHPEPQTPKDSPSKSSAEAQTPEDTPNKS 84
Query: 113 GVEKKGE---------------GTT-------------TAEAAPATGSKPDEPGKAG--- 141
G E K + G+T T+++ P + D GK+G
Sbjct: 85 GAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDSTSKSHPELQTPKDSTGKSGAEA 144
Query: 142 ETPSEEKKGEG-DAATEQAAPQAPASSEEKAGSAETESATKAST--DNSPSSKAEDAPAK 198
+TP + G +A T++ +P S + +S T D S S AED K
Sbjct: 145 QTPEDSPNRSGAEAKTQKDSPSKSGSEAQTTKDVPNKSGADGQTPKDGSSKSGAEDQTPK 204
Query: 199 EEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENI--EAVDETKPKES 256
+ P + + A TP + A Q P + S AEE ++ ++ P++
Sbjct: 205 DVPNK-------SGAEKQTPKDGSNKSGAEEQGPIDGPSKSGAEEQTSKDSPNKVVPEQP 257
Query: 257 ARQDEGK--------EEEPEAD 270
+R+D K +E P+AD
Sbjct: 258 SRKDHSKPISNPSDNKELPKAD 279
Score = 32.3 bits (72), Expect = 0.46
Identities = 27/145 (18%), Positives = 56/145 (38%), Gaps = 11/145 (7%)
Query: 124 AEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAS 183
A A P ++ + +AG PS G+ +T P+ S+ GS ++ +
Sbjct: 15 AGAVPLLATESVKQEEAGVRPSA-----GNVSTH------PSLSQRPGGSTKSHPEPQTP 63
Query: 184 TDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEE 243
D+ S AE ++ P ++ A ++ AE K + ++++
Sbjct: 64 KDSPSKSSAEAQTPEDTPNKSGAEAKTQKDSSNKSGAEAKTQKGSTSKSGSEAQTTKDST 123
Query: 244 NIEAVDETKPKESARQDEGKEEEPE 268
+ + PK+S + + + PE
Sbjct: 124 SKSHPELQTPKDSTGKSGAEAQTPE 148
>gi|14790190 spen homolog, transcriptional regulator [Homo sapiens]
Length = 3664
Score = 51.6 bits (122), Expect = 7e-07
Identities = 55/202 (27%), Positives = 82/202 (40%), Gaps = 21/202 (10%)
Query: 82 ITRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAG 141
+TR + K EK+ D + E E + E + + P+ G
Sbjct: 1590 LTRMQQK-EKEKDQKPKEVEKQEDTENHPKTPESAPENKDSELKTPPSVGPPSVTVVTLE 1648
Query: 142 ETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEP 201
PS +K GD E AP +EEK E AT S + P+S+ AP E+
Sbjct: 1649 SAPSALEKTTGDKTVE-----APLVTEEKT----VEPAT-VSEEAKPASEPAPAPV-EQL 1697
Query: 202 KQADVP--------AAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIE-AVDETK 252
+Q D+P AA+ A ++ D A+PPT SQAE N++ D T+
Sbjct: 1698 EQVDLPPGADPDKEAAMMPAGVEEGSSGDQPPYLDAKPPTPGASFSQAESNVDPEPDSTQ 1757
Query: 253 PKESARQDEGKEEEPEADQEHA 274
P Q + EP+A++ A
Sbjct: 1758 PLSKPAQKSEEANEPKAEKPDA 1779
Score = 45.1 bits (105), Expect = 7e-05
Identities = 47/213 (22%), Positives = 84/213 (39%), Gaps = 13/213 (6%)
Query: 64 EDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAE-AEANKKDEAPVADGVEKKGEGTT 122
E + +AA RG + + + +++++ +A E AE K E + +K
Sbjct: 1935 ERELQEAAAVPTTPRRGRPPKTRRRADEEEENEAKEPAETLKPPEGWRSPRSQK------ 1988
Query: 123 TAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKA 182
TA G K K T E G + + P ++EE+AGS + A
Sbjct: 1989 TAAGGGPQGKKGKNEPKVDATRPEATTEVGPQIGVKESSMEPKAAEEEAGSEQKRDRKDA 2048
Query: 183 STDNSPSSKA-----EDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGE 237
TD +P A E PA E+ ++ + + A +A A P +
Sbjct: 2049 GTDKNPPETAPVEVVEKKPAPEKNSKSKRGRSRNSRLAVDKSASLKNVDAAVSPRGAAAQ 2108
Query: 238 SSQAEENIEAVDETKPKESARQDEGKEEEPEAD 270
+ + E + AV K ES ++++G + ++D
Sbjct: 2109 AGERESGVVAVSPEK-SESPQKEDGLSSQLKSD 2140
Score = 43.5 bits (101), Expect = 2e-04
Identities = 48/212 (22%), Positives = 73/212 (34%), Gaps = 8/212 (3%)
Query: 45 SRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 104
S +EK D+ +E + E A +A + E+ + V
Sbjct: 1652 SALEKTTGDKTVEAPLVTEEKTVEPATVSEEAKPASEPAPAPV--EQLEQVDLPPGADPD 1709
Query: 105 KDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAP 164
K+ A + GVE+ G + P +KP PG + E D+ T+ + A
Sbjct: 1710 KEAAMMPAGVEEGSSG----DQPPYLDAKPPTPGASFSQAESNVDPEPDS-TQPLSKPAQ 1764
Query: 165 ASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAA 224
S E AE AT A + + KAE AP + P D+ AA +
Sbjct: 1765 KSEEANEPKAEKPDAT-ADAEPDANQKAEAAPESQPPASEDLEVDPPVAAKDKKPNKSKR 1823
Query: 225 AKATAQPPTETGESSQAEENIEAVDETKPKES 256
+K Q + E +D K K S
Sbjct: 1824 SKTPVQAAAVSIVEKPVTRKSERIDREKLKRS 1855
Score = 41.6 bits (96), Expect = 8e-04
Identities = 47/193 (24%), Positives = 72/193 (37%), Gaps = 17/193 (8%)
Query: 85 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETP 144
+K KG +K + NKK APV V + + + AA G+ P E P
Sbjct: 2327 RKDKGRQKTTRSRRKRNTNKKVVAPVESHVPESNQAQGESPAANE-GTTVQHP----EAP 2381
Query: 145 SEEKKGEGDAATEQAA--------PQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP 196
EEK+ E +T + P SS+E S E + TKAS + AP
Sbjct: 2382 QEEKQSEKPHSTPPQSCTSDLSKIPSTENSSQEI--SVEERTPTKASVPPDLPPPPQPAP 2439
Query: 197 AKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKES 256
EEP+ ++ + TP ++ + T P+ T + P
Sbjct: 2440 VDEEPQARFRVHSIIESDPVTPPSDPSIPIPTL--PSVTAAKLSPPVASGGIPHQSPPTK 2497
Query: 257 ARQDEGKEEEPEA 269
+ ++EEP A
Sbjct: 2498 VTEWITRQEEPRA 2510
Score = 32.0 bits (71), Expect = 0.60
Identities = 39/178 (21%), Positives = 61/178 (34%), Gaps = 15/178 (8%)
Query: 96 QAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 155
+ A A+A +++ VA EK + S P +P K E G A
Sbjct: 2103 RGAAAQAGERESGVVAVSPEKSESPQKEDGLSSQLKSDPVDPDKEPEKEDVSASGPSPEA 2162
Query: 156 TEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAA 215
T+ A + E SA+ A ++P A + + K A + AAA
Sbjct: 2163 TQLAKQMELEQAVEHIAKLAEASASAAYKADAPEGLAPE----DRDKPAHQASETELAAA 2218
Query: 216 TTPAAEDAAAKAT--AQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 271
D + + PP GES + +P A+ + EE E D+
Sbjct: 2219 IGSIINDISGEPENFPAPPPYPGESQ---------TDLQPPAGAQALQPSEEGMETDE 2267
Score = 29.6 bits (65), Expect = 3.0
Identities = 17/42 (40%), Positives = 18/42 (42%)
Query: 188 PSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATA 229
P+SKA P KE K D AA T A P A A A
Sbjct: 3221 PASKAPQQPGKEAAKTPDAKAAPTPTPAPVPVPVPLPAPAPA 3262
Score = 28.9 bits (63), Expect = 5.1
Identities = 29/177 (16%), Positives = 68/177 (38%), Gaps = 10/177 (5%)
Query: 28 RAVRPSPYSLGFLTFWISRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKL 87
R R PY + + E+ + ++ E D D+ H+ ++ H+ R +
Sbjct: 681 RDYRNDPYEQDIREYSYRQRERERERERFESD----RDRDHERRPIERSQSPVHLRRPQS 736
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
G + +++ ++ + +D + + +P K D+ T +E+
Sbjct: 737 PGASPSQAERLPSDSERRLYSRSSD------RSGSCSSLSPPRYEKLDKSRLERYTKNEK 790
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA 204
E E+ + +EK +T+ + +SPSS++ + + E +Q+
Sbjct: 791 TDKERTFDPERVERERRLIRKEKVEKDKTDKQKRKGKVHSPSSQSSETDQENEREQS 847
Score = 28.5 bits (62), Expect = 6.6
Identities = 17/85 (20%), Positives = 35/85 (41%)
Query: 131 GSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS 190
G +P+ + + S + + ++ A QA + +GS ++ + + +S SS
Sbjct: 230 GRRPERNYQHSRSRSPHSSQSRNQSPQRLASQASRPTRSPSGSGSRSRSSSSDSISSSSS 289
Query: 191 KAEDAPAKEEPKQADVPAAVTAAAA 215
+ D+ D PA +AA
Sbjct: 290 TSSDSSDSSSSSSDDSPARSVQSAA 314
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 51.6 bits (122), Expect = 7e-07
Identities = 47/184 (25%), Positives = 74/184 (40%), Gaps = 9/184 (4%)
Query: 90 EKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE---PGKAGETPSE 146
EK + + EA +K+ E EG TT E P+E K G E
Sbjct: 865 EKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIE 924
Query: 147 EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADV 206
+ + EG E + EEKA + E E + ++ S ++ +P ++E
Sbjct: 925 KFEDEGAGFEESSET---GDYEEKAETEEAEEPEEDGEEHVCVSASKHSPTEDEESAKAE 981
Query: 207 PAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEE 266
A + A+ D A+ E GE+ Q+EE DE E AR++E + E+
Sbjct: 982 ADAYIREKRESVASGDDRAEEDMDEAIEKGEAEQSEEE---ADEEDKAEDAREEEYEPEK 1038
Query: 267 PEAD 270
EA+
Sbjct: 1039 MEAE 1042
Score = 47.8 bits (112), Expect = 1e-05
Identities = 56/234 (23%), Positives = 92/234 (39%), Gaps = 26/234 (11%)
Query: 52 DDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVA 111
+D+K E++ KP+ + K K ++++K E K +++ E + KK+
Sbjct: 647 EDKKEEKE--KPKKEVAKKEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKET 704
Query: 112 DGVEKKGEGTTTAEAAPATGSKPDEPGKA-GETPSEEKKGEGDAATEQAAPQAPASSEEK 170
E K E E + EP K + P + KK ++T + + PA+ + K
Sbjct: 705 PPKEVKKE--VKKEEKKEVKKEEKEPKKEIKKLPKDAKK----SSTPLSEAKKPAALKPK 758
Query: 171 AGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQ 230
E + P K + K+E K A+ AA ATT A AA A
Sbjct: 759 VPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIAAIG 818
Query: 231 PP----------------TETGESSQAEENIEAVDETKPKESARQDEGKEEEPE 268
P T+ E +AEE ++ + KP+ +DE K +E E
Sbjct: 819 PAKELEAERSLMSSPEDLTKDFEELKAEE-VDVTKDIKPQLELIEDEEKLKETE 871
Score = 46.6 bits (109), Expect = 2e-05
Identities = 54/194 (27%), Positives = 84/194 (43%), Gaps = 21/194 (10%)
Query: 93 DDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEK---K 149
DD++ E E +E+ E+K E T AE G + + +P+E++ K
Sbjct: 921 DDIEKFEDEGAGFEESSETGDYEEKAE-TEEAEEPEEDGEEHVCVSASKHSPTEDEESAK 979
Query: 150 GEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSS-----KAEDAPAKE-EPKQ 203
E DA + ++ AS +++A E+ K + S KAEDA +E EP++
Sbjct: 980 AEADAYIREKR-ESVASGDDRAEEDMDEAIEKGEAEQSEEEADEEDKAEDAREEEYEPEK 1038
Query: 204 A---DVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAV-DETKPKES--- 256
D AV AA AE+ T P + G S E ++ DET P S
Sbjct: 1039 MEAEDYVMAVVDKAAEAGGAEEQYGFLTT-PTKQLGAQSPGREPASSIHDETLPGGSESE 1097
Query: 257 --ARQDEGKEEEPE 268
A +E +E++PE
Sbjct: 1098 ATASDEENREDQPE 1111
Score = 39.3 bits (90), Expect = 0.004
Identities = 60/274 (21%), Positives = 102/274 (37%), Gaps = 46/274 (16%)
Query: 23 RKNLQRAVRPSPYSLGFLTFWISRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHI 82
R++L+ A +P P V K ++ E + +K K +K + +
Sbjct: 542 RESLKPAAKPLPSK---------SVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKD- 591
Query: 83 TRKKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGE 142
K +K E K V E + K++ +PV V +K +AA K + K +
Sbjct: 592 --KPIKTETKPSVTEKEVPS-KEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPED 648
Query: 143 TPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAE-----DAPA 197
E++K + + A ++ + P EEK E + K + + + P
Sbjct: 649 KKEEKEKPKKEVAKKE--DKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPP 706
Query: 198 KE------------------EPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESS 239
KE EPK+ A ++TP +E A A +P E S
Sbjct: 707 KEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSE-AKKPAALKPKVPKKEES 765
Query: 240 QAEENIEAVDETKPKESAR----QDEGKEEEPEA 269
++++ A KPKE + + EGK E A
Sbjct: 766 VKKDSVAA---GKPKEKGKIKVIKKEGKAAEAVA 796
Score = 33.9 bits (76), Expect = 0.16
Identities = 37/191 (19%), Positives = 68/191 (35%), Gaps = 33/191 (17%)
Query: 112 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATE--QAAPQAPASSEE 169
DG G+ + + E S P+ G + ET ++ + D +T + A + + +
Sbjct: 1996 DGGHTLGDPSYSYETTEKITSFPESEGYSYETSTKTTRTP-DTSTYCYETAEKITRTPQA 2054
Query: 170 KAGSAETESATKASTDNSPSSKAEDAP-----------------------------AKEE 200
S ET + SPS +D A EE
Sbjct: 2055 STYSYETSDLCYTAEKKSPSEARQDVDLCLVSSCEYKHPKTELSPSFINPNPLEWFASEE 2114
Query: 201 P-KQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQ 259
P ++++ P + A P + + PPT ES+ ++ + + ET+ S
Sbjct: 2115 PTEESEKPLTQSGGAPPPPGGKQQGRQCDETPPTSVSESAPSQTDSDVPPETEECPSITA 2174
Query: 260 DEGKEEEPEAD 270
D + E E++
Sbjct: 2175 DANIDSEDESE 2185
Score = 32.0 bits (71), Expect = 0.60
Identities = 31/125 (24%), Positives = 49/125 (39%), Gaps = 8/125 (6%)
Query: 85 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAA-PATGSKPDEPGKAGET 143
K LK + K+ + + K +PV KK +G + AA P + K
Sbjct: 2233 KALKKDLKEKTKTKKPGTKTKSSSPV-----KKSDGKSKPLAASPKPAGLKESSDKVSRV 2287
Query: 144 PSEEKKGEGD-AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPK 202
S +KK + AA P+ A+ E+ ET++A AS S + + K
Sbjct: 2288 ASPKKKESVEKAAKPTTTPEVKAARGEEKDK-ETKNAANASASKSAKTATAGPGTTKTTK 2346
Query: 203 QADVP 207
+ VP
Sbjct: 2347 SSAVP 2351
Score = 29.3 bits (64), Expect = 3.9
Identities = 31/120 (25%), Positives = 47/120 (39%), Gaps = 18/120 (15%)
Query: 61 IKPEDKAHKAATKIQASFRGHITRKKLK---------GEKKDDVQAAEAEANKKDEAPVA 111
+K + K K TK ++S + K K G K+ + + + KK E+
Sbjct: 2239 LKEKTKTKKPGTKTKSSSPVKKSDGKSKPLAASPKPAGLKESSDKVSRVASPKKKES--- 2295
Query: 112 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKA 171
VEK + TTT E A G + D+ K S K A T A P +++ A
Sbjct: 2296 --VEKAAKPTTTPEVKAARGEEKDKETKNAANASASK----SAKTATAGPGTTKTTKSSA 2349
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 51.2 bits (121), Expect = 1e-06
Identities = 56/237 (23%), Positives = 89/237 (37%), Gaps = 11/237 (4%)
Query: 47 VEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGE--KKDDV---QAAEAE 101
+ ++++D ++ + P+ K KAA T+K KK V + A A
Sbjct: 33 MSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAAT 92
Query: 102 ANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDE--PGKAGETPSEEKKGEGDAATEQA 159
KK P +G T +A AT K P K + KK + D +
Sbjct: 93 PAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDD 152
Query: 160 APQAPASSE-EKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPA---AVTAAAA 215
+ + E E E E A + +P+S+ ED E+ + D + A
Sbjct: 153 SEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAME 212
Query: 216 TTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 272
TTPA AAK E EE+ E D+ ++ D+ +EE E ++E
Sbjct: 213 TTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEE 269
Score = 38.1 bits (87), Expect = 0.008
Identities = 44/180 (24%), Positives = 68/180 (37%), Gaps = 6/180 (3%)
Query: 96 QAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAA 155
+A A KK A A G K G+ ++ +E + E E++ E + A
Sbjct: 116 KALVATPGKKGAAIPAKGA-KNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDED-EIEPA 173
Query: 156 TEQAAPQAPASSEEKAGSAET-ESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAA 214
+AA APAS +E E E D+S E PAK + VP A
Sbjct: 174 AMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVA 233
Query: 215 ATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEHA 274
ED + + + + +E E +E +P + A GK ++ A Q+ A
Sbjct: 234 EDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEA---PGKRKKEMAKQKAA 290
Score = 31.2 bits (69), Expect = 1.0
Identities = 36/159 (22%), Positives = 55/159 (34%), Gaps = 20/159 (12%)
Query: 85 KKLKGEKKDDVQAAEAEANKKDEAPVADGVEKKGE----GTTTAEAAPATGSKPDEPG-- 138
K K KK+D E + +++DE D E + E A AAPA+ + DE
Sbjct: 135 KNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDED 194
Query: 139 --------------KAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST 184
+A ET + K +A A EE+ E + +
Sbjct: 195 DEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDE 254
Query: 185 DNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDA 223
D+ E+ +EE + P A AA +A
Sbjct: 255 DDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEA 293
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 51.2 bits (121), Expect = 1e-06
Identities = 56/242 (23%), Positives = 94/242 (38%), Gaps = 29/242 (11%)
Query: 48 EKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDE 107
EK + +K E + E K K A K + T+K++KG K++ V+ A+ + +
Sbjct: 188 EKIEKKEKPETKTLAKEQKKAKTAEKSEEK-----TKKEVKGGKQEKVKQTAAKVKEVQK 242
Query: 108 APVADGVEKKGEGTTTAEAAPATGSKPDEPG--------------KAGETPSEEKKGEGD 153
P K E +AA + + D+ K G++P+
Sbjct: 243 TP-----SKPKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPP---- 293
Query: 154 AATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQA-DVPAAVTA 212
TEQA+ PAS + E + A K T + + ED K E + A DV
Sbjct: 294 LPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPG 353
Query: 213 AAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQE 272
A+ T A A E E S+ + V++ K K+ ++++ E +E
Sbjct: 354 KASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKE 413
Query: 273 HA 274
H+
Sbjct: 414 HS 415
Score = 47.4 bits (111), Expect = 1e-05
Identities = 51/206 (24%), Positives = 83/206 (40%), Gaps = 42/206 (20%)
Query: 88 KGEKKDDVQAAEAEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE 147
+GEKK + +E KK++ + ++KK E T + + EPGKA ET
Sbjct: 313 EGEKKKAEKKVTSETKKKEK----EDIKKKSEKETAIDV------EKKEPGKASET---- 358
Query: 148 KKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAED------APAKEEP 201
K+G T + A QA A +EK +++ K + P K ++ PAK
Sbjct: 359 KQG-----TVKIAAQAAAKKDEK--KEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPK 411
Query: 202 KQADVPAAVTAAAATTPAAEDAAAKA---------------TAQPPTETGESSQAEENIE 246
K+ VP+ A T A E+ A + T + +S + ++
Sbjct: 412 KEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILK 471
Query: 247 AVDETKPKESARQDEGKEEEPEADQE 272
+ K KE KE+EPE ++
Sbjct: 472 DKEPIKGKEEKVPASLKEKEPETKKD 497
Score = 42.7 bits (99), Expect = 3e-04
Identities = 52/221 (23%), Positives = 83/221 (37%), Gaps = 17/221 (7%)
Query: 63 PEDKAHKAATKIQASFRGHITRKKLKGEKKDD--VQAAEAEANKKDEAPVADGVEKKGEG 120
P DK KA T+ G ++ KK KK++ + E E K+ + ++ K
Sbjct: 417 PSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPI 476
Query: 121 TTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESAT 180
E PA+ K EP ET +EK + + PQ EEK + A
Sbjct: 477 KGKEEKVPAS-LKEKEP----ETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAK 531
Query: 181 KASTDNSPSSKAE-------DAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPT 233
A ++ K + + K E K AVT P A +PP+
Sbjct: 532 PAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPS 591
Query: 234 -ETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEH 273
+T + + V E+ K++ + KE + +AD +H
Sbjct: 592 IKTDKPKPTPKGTSEVTESGKKKTEISE--KESKEKADMKH 630
Score = 29.6 bits (65), Expect = 3.0
Identities = 42/177 (23%), Positives = 70/177 (39%), Gaps = 27/177 (15%)
Query: 53 DQKIEQDG--IKPED------KAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK 104
D+K+ + G +KP+ K K +I+ + I+ +K++ K+D V+ + ++
Sbjct: 497 DEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAIS-EKVQIHKQDIVKPEKTVSHG 555
Query: 105 KDEAPV-----ADGVEKKGEGTTTAEAA---------PATGSKPDEPGKAGETPSEEKKG 150
K E V A +EK + T +A KP G + T S +KK
Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
Query: 151 EGDAATEQAAPQAPASSEEKAG----SAETESATKASTDNSPSSKAEDAPAKEEPKQ 203
E + EEK S + + TKA S ED PA ++ K+
Sbjct: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKE 672
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 49.7 bits (117), Expect = 3e-06
Identities = 49/208 (23%), Positives = 83/208 (39%), Gaps = 35/208 (16%)
Query: 64 EDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEAEANK--KDEAPVADGVEKKGEGT 121
ED K K +A ++ + E ++D + EA K KDE DG E K G
Sbjct: 106 EDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKN-GN 164
Query: 122 TTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATK 181
E A K E GK GE + KG G+ E+ + ++ G + K
Sbjct: 165 EKGEDA-----KEKEDGKKGE----DGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGK 215
Query: 182 ASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAAEDAAAKATAQPPTETGESSQA 241
D + +D KE+ K+ + ED E+ +
Sbjct: 216 EKGDKK---EGKDVKVKEDEKERE------------DGKEDEGGNEE--------EAGKE 252
Query: 242 EENIEAVDETKPKESARQDEGKEEEPEA 269
+E+++ +E K ++ ++D+GK+EEP++
Sbjct: 253 KEDLKEEEEGKEEDEIKEDDGKKEEPQS 280
>gi|7662162 ALEX2 protein [Homo sapiens]
Length = 632
Score = 48.9 bits (115), Expect = 5e-06
Identities = 71/269 (26%), Positives = 95/269 (35%), Gaps = 61/269 (22%)
Query: 62 KPEDKAHKAA-TKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD--GVEKKG 118
KP+++A + +A R T G AEAE +DEA D G E
Sbjct: 40 KPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVA 99
Query: 119 EGTTTAEAAPATGSKPDEPGKAGETPSEEKK-------------------GEGDAATEQA 159
++AEA GS+ E AG P E G +A
Sbjct: 100 PAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAG 159
Query: 160 AP---QAPASSEEKAGSAE------TESATKASTDNSPS----SKAEDAPAKEEPKQA-- 204
AP +AP +E + TE+A P +K +AP P +A
Sbjct: 160 APKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAE 219
Query: 205 -DVPAAVTAAAATTPAAE----------------DAAAKATAQPPTETGESSQAEENIEA 247
VPA T AAA T AAE AA KAT P TG +A A
Sbjct: 220 APVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKAT--PGAHTGAIPKATSATGA 277
Query: 248 VDETKPKESAR-----QDEGKEEEPEADQ 271
V + K R + +GK+ + E D+
Sbjct: 278 VPKGGGKGVTRSRNGGKGKGKKSKVEVDE 306
Score = 34.3 bits (77), Expect = 0.12
Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%)
Query: 121 TTTAEA-APATGSKPDEPGKAGETPSEEKKGE-----GDAATEQAAPQAPASSEEKAGSA 174
T AEA PAT + P A E+P G +A ++A P A + KA SA
Sbjct: 215 TEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSA 274
Query: 175 E---TESATKASTDNSPSSKAEDAPAKEEPKQADVP--AAVTAAAATTPAAEDAAAKATA 229
+ K T + K + +K E + + AAAA +A A
Sbjct: 275 TGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE 334
Query: 230 QPPTETGES--SQAEENIEAVDETKPKESARQDEGKEEEP 267
P +E GES + E + ++ ET+ + R+ ++ P
Sbjct: 335 VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRP 374
>gi|29540562 ALEX2 protein [Homo sapiens]
Length = 632
Score = 48.9 bits (115), Expect = 5e-06
Identities = 71/269 (26%), Positives = 95/269 (35%), Gaps = 61/269 (22%)
Query: 62 KPEDKAHKAA-TKIQASFRGHITRKKLKGEKKDDVQAAEAEANKKDEAPVAD--GVEKKG 118
KP+++A + +A R T G AEAE +DEA D G E
Sbjct: 40 KPKNRAVAGTGARARAGLRAGFTIDLGSGFSPPTPVRAEAEDRAQDEASALDTVGAEAVA 99
Query: 119 EGTTTAEAAPATGSKPDEPGKAGETPSEEKK-------------------GEGDAATEQA 159
++AEA GS+ E AG P E G +A
Sbjct: 100 PAASSAEAQSGAGSQAQEADGAGVGPKAESVVGAAMASAIAPPPGVTEALGAAEAPAMAG 159
Query: 160 AP---QAPASSEEKAGSAE------TESATKASTDNSPS----SKAEDAPAKEEPKQA-- 204
AP +AP +E + TE+A P +K +AP P +A
Sbjct: 160 APKVAEAPREAETSRAAVPPGTVVPTEAAAPTEVTEGPGVAAPTKVAEAPGVASPTEAAE 219
Query: 205 -DVPAAVTAAAATTPAAE----------------DAAAKATAQPPTETGESSQAEENIEA 247
VPA T AAA T AAE AA KAT P TG +A A
Sbjct: 220 APVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKAT--PGAHTGAIPKATSATGA 277
Query: 248 VDETKPKESAR-----QDEGKEEEPEADQ 271
V + K R + +GK+ + E D+
Sbjct: 278 VPKGGGKGVTRSRNGGKGKGKKSKVEVDE 306
Score = 34.3 bits (77), Expect = 0.12
Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 13/160 (8%)
Query: 121 TTTAEA-APATGSKPDEPGKAGETPSEEKKGE-----GDAATEQAAPQAPASSEEKAGSA 174
T AEA PAT + P A E+P G +A ++A P A + KA SA
Sbjct: 215 TEAAEAPVPATPTGAAAPTGAAESPGTSGSPRTAVVPGTSAAKKATPGAHTGAIPKATSA 274
Query: 175 E---TESATKASTDNSPSSKAEDAPAKEEPKQADVP--AAVTAAAATTPAAEDAAAKATA 229
+ K T + K + +K E + + AAAA +A A
Sbjct: 275 TGAVPKGGGKGVTRSRNGGKGKGKKSKVEVDELGMGFRPGDGAAAAAAASANGGQAFLAE 334
Query: 230 QPPTETGES--SQAEENIEAVDETKPKESARQDEGKEEEP 267
P +E GES + E + ++ ET+ + R+ ++ P
Sbjct: 335 VPDSEEGESGWTDTESDSDSEPETQRRGRGRRPVAMQKRP 374
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 48.9 bits (115), Expect = 5e-06
Identities = 56/241 (23%), Positives = 94/241 (39%), Gaps = 28/241 (11%)
Query: 54 QKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAEA-EANKKDEA-PVA 111
QK E+ + E++ K+A + S + R+ L + + A+ A E + K +A P +
Sbjct: 413 QKKEKKDKERENEKEKSALARERSLK---KRQSLPASPRARLSASTASELSPKSKARPSS 469
Query: 112 DGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEE----KKGEGDAATEQAAPQAPASS 167
+ P P P G T S + +K E + A P+ + S
Sbjct: 470 PSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPEDKSQS 529
Query: 168 EEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPAA------- 220
+ +A S E ESA AS SP+ AP ++E A+ P AA T+P A
Sbjct: 530 KRRA-SNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETP--TDAAVLTSPPAPAPPVTP 586
Query: 221 ---------EDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQ 271
+ A + A+ + E + EE + + K + +E E A++
Sbjct: 587 SKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEARAER 646
Query: 272 E 272
E
Sbjct: 647 E 647
Score = 28.1 bits (61), Expect = 8.6
Identities = 39/186 (20%), Positives = 75/186 (40%), Gaps = 18/186 (9%)
Query: 71 ATKIQASFRGHITRKKLKGEKKDDVQAAEAEANKK-DEAPVADGVEKKGEGTTTAEAAPA 129
AT++ A R ++ E+++ + +AE +K+ E +A E + E AEA
Sbjct: 599 ATRLLAEKRRQAREQR---EREEQERRLQAERDKRMREEQLAREAEARAE--REAEARRR 653
Query: 130 TGSKPDEPGKAGETPSE---EKKGEGDAATEQAAPQAPASSEEKAGSAETESATKAST-- 184
+ E +A + E ++K E +A + + A + E+ E E +
Sbjct: 654 EEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRKRLE 713
Query: 185 ---DNSPSSKAEDAPAKEEPKQADV----PAAVTAAAATTPAAEDAAAKATAQPPTETGE 237
+ S+ + K++ K+A+ P V A A +P + A + P E
Sbjct: 714 EIMKRTRKSEVSETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQKEEPIPQEPQW 773
Query: 238 SSQAEE 243
S ++E
Sbjct: 774 SLPSKE 779
>gi|169658378 trinucleotide repeat containing 18 [Homo sapiens]
Length = 2968
Score = 48.5 bits (114), Expect = 6e-06
Identities = 46/235 (19%), Positives = 94/235 (40%), Gaps = 12/235 (5%)
Query: 40 LTFWISRVEKNDDDQKIEQDGIKPEDKAHKAATKIQASFRGHITRKKLKGEKKDDVQAAE 99
LTF S K+ D + EQDG + + + +++ +S + G + + E
Sbjct: 2533 LTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSSSSS----SSSSSSGSETE----GE 2584
Query: 100 AEANKKDEAPVADGVEKKGEGTTTAEAAPATGSKPDEPGKAGETPSEEKKGEGDAATEQA 159
E +K + G ++ A A+PA+ S + + S +++ +
Sbjct: 2585 EEGDKNGDGGCGTGGRNCSAASSRA-ASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643
Query: 160 APQAPASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQADVPAAVTAAAATTPA 219
+ + +SS + S+ + S++ +S+ +S S+ ED+ + + A P A +A A P
Sbjct: 2644 S--SSSSSSSSSSSSSSSSSSSSSSSSSSSTTDEDSSCSSDDEAAPAPTAGPSAQAALPT 2701
Query: 220 -AEDAAAKATAQPPTETGESSQAEENIEAVDETKPKESARQDEGKEEEPEADQEH 273
A A KA + ++ + T+P + Q K + + H
Sbjct: 2702 KATKQAGKARPSAHSPGKKTPAPQPQAPPPQPTQPLQPKAQAGAKSRPKKREGVH 2756
Score = 35.8 bits (81), Expect = 0.041
Identities = 42/179 (23%), Positives = 68/179 (37%), Gaps = 32/179 (17%)
Query: 123 TAEAAPATGSKPDEPGKA----GETPSEEKKGEGDAATEQA-----APQAPASSEEKAGS 173
T E + +EPG G PS + KG+ A E+ P P + E +
Sbjct: 2311 TGEGKDGGTAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTP 2370
Query: 174 AETESATKASTDNSPSSKAEDAPAKEEPKQ------------ADVPAAVTAAAA----TT 217
+S + + + KA AP + P A++PA T+ A T
Sbjct: 2371 GSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITM 2430
Query: 218 PAAED------AAAKATAQPPTETGESSQAEENIEAVDETKPK-ESARQDEGKEEEPEA 269
PA AA ++ A+ P GE ++ ++ T PK + A++ E+P A
Sbjct: 2431 PATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHEGVTSPKSKKAKEALLLREDPGA 2489
Score = 33.5 bits (75), Expect = 0.21
Identities = 43/157 (27%), Positives = 61/157 (38%), Gaps = 14/157 (8%)
Query: 130 TGSKPDEPGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKA----STD 185
TG D E P + +G G + +A A+ EE + E S A ST
Sbjct: 2311 TGEGKDGGTAGSEEPGAKARGRGRKPSAKAKGDRAATLEEGNPTDEVPSTPLALEPSSTP 2370
Query: 186 NSPSSKAE--DAPAK------EEPKQADVPAAVTAAAATTPAAE-DAAAKATAQPPTETG 236
S S E D AK P+ + P A T+ A P AE A A + A P T
Sbjct: 2371 GSKKSPPEPVDKRAKAPKARPAPPQPSPAPPAFTSCPAPEPFAELPAPATSLAPAPLITM 2430
Query: 237 ESSQAE-ENIEAVDETKPKESARQDEGKEEEPEADQE 272
+++ + + A +E+ K R E E + D E
Sbjct: 2431 PATRPKPKKARAAEESGAKGPRRPGEEAELLVKLDHE 2467
Score = 32.3 bits (72), Expect = 0.46
Identities = 26/124 (20%), Positives = 53/124 (42%), Gaps = 10/124 (8%)
Query: 137 PGKAGETPSEEKKGEGDAATEQAAPQAPASSEEKAGSAETESATKASTDNSPSSKAEDAP 196
PG E K + A + A ++ +SS +GS+ +S+ +S SS +E
Sbjct: 2531 PGLTFEDSGNPKSPDKAQAEQDGAEESESSSSSSSGSS-------SSSSSSSSSGSETEG 2583
Query: 197 AKEEPKQADVPAAV---TAAAATTPAAEDAAAKATAQPPTETGESSQAEENIEAVDETKP 253
+E K D +AA++ AA A++ +++ + + SS + + + +
Sbjct: 2584 EEEGDKNGDGGCGTGGRNCSAASSRAASPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2643
Query: 254 KESA 257
S+
Sbjct: 2644 SSSS 2647
Score = 32.0 bits (71), Expect = 0.60
Identities = 31/125 (24%), Positives = 47/125 (37%), Gaps = 11/125 (8%)
Query: 146 EEKKGEGDAATEQAAPQA--PASSEEKAGSAETESATKASTDNSPSSKAEDAPAKEEPKQ 203
+ +KG+G P A P S A SA T +S + S + D PAKE +
Sbjct: 153 DTQKGQGPGGDGFYLPTAGAPGSLHSHAPSARTPGGGHSSGAPAKGSSSRDGPAKERAGR 212
Query: 204 ADVPAAVTAAAATTPAAEDAAA---------KATAQPPTETGESSQAEENIEAVDETKPK 254
P + E+A+ +A A+ + G AE + E+K K
Sbjct: 213 GGEPPPLFGKKDPRARGEEASGPRGVVDLTQEARAEGRQDRGPPRLAERLSPFLAESKTK 272
Query: 255 ESARQ 259
+A Q
Sbjct: 273 NAALQ 277
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.299 0.117 0.317
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,682,606
Number of Sequences: 37866
Number of extensions: 592967
Number of successful extensions: 10951
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 476
Number of HSP's successfully gapped in prelim test: 1222
Number of HSP's that attempted gapping in prelim test: 5334
Number of HSP's gapped (non-prelim): 4802
length of query: 274
length of database: 18,247,518
effective HSP length: 101
effective length of query: 173
effective length of database: 14,423,052
effective search space: 2495187996
effective search space used: 2495187996
T: 11
A: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.6 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.