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Search of human proteins with 191252785
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|191252785 centrobin, centrosomal BRCA2 interacting protein
isoform alpha [Homo sapiens]
(903 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|191252785 centrobin, centrosomal BRCA2 interacting protein is... 1776 0.0
gi|80861396 centrobin, centrosomal BRCA2 interacting protein iso... 1763 0.0
gi|148746195 trichohyalin [Homo sapiens] 107 7e-23
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 104 4e-22
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 104 4e-22
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 104 4e-22
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 104 4e-22
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 104 4e-22
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 104 4e-22
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 104 4e-22
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 104 4e-22
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 89 1e-17
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 89 1e-17
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 89 1e-17
gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 88 3e-17
gi|16262452 cingulin [Homo sapiens] 87 5e-17
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 87 7e-17
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 87 7e-17
gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] 86 2e-16
gi|21735548 centrosomal protein 2 [Homo sapiens] 86 2e-16
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 85 3e-16
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 85 3e-16
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 84 8e-16
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 84 8e-16
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 84 8e-16
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 84 8e-16
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 83 1e-15
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 82 2e-15
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 82 2e-15
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 2e-15
>gi|191252785 centrobin, centrosomal BRCA2 interacting protein
isoform alpha [Homo sapiens]
Length = 903
Score = 1776 bits (4600), Expect = 0.0
Identities = 903/903 (100%), Positives = 903/903 (100%)
Query: 1 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60
MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS
Sbjct: 1 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60
Query: 61 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120
TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD
Sbjct: 61 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120
Query: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180
PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP
Sbjct: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180
Query: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240
PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA
Sbjct: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240
Query: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300
RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR
Sbjct: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300
Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ
Sbjct: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420
TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD
Sbjct: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420
Query: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH
Sbjct: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
Query: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540
HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ
Sbjct: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540
Query: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600
QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW
Sbjct: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600
Query: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660
TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL
Sbjct: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660
Query: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720
TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV
Sbjct: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720
Query: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780
PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH
Sbjct: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780
Query: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTD 840
SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTD
Sbjct: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTD 840
Query: 841 GRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGG 900
GRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGG
Sbjct: 841 GRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGG 900
Query: 901 VWR 903
VWR
Sbjct: 901 VWR 903
>gi|80861396 centrobin, centrosomal BRCA2 interacting protein
isoform beta [Homo sapiens]
Length = 925
Score = 1763 bits (4567), Expect = 0.0
Identities = 903/925 (97%), Positives = 903/925 (97%), Gaps = 22/925 (2%)
Query: 1 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60
MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS
Sbjct: 1 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60
Query: 61 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120
TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD
Sbjct: 61 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120
Query: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180
PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP
Sbjct: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180
Query: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240
PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA
Sbjct: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240
Query: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300
RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR
Sbjct: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300
Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ
Sbjct: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420
TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD
Sbjct: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420
Query: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH
Sbjct: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
Query: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540
HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ
Sbjct: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540
Query: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600
QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW
Sbjct: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600
Query: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660
TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL
Sbjct: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660
Query: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720
TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV
Sbjct: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720
Query: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780
PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH
Sbjct: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780
Query: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEH---- 836
SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEH
Sbjct: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGYK 840
Query: 837 ------------------SGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT 878
SGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT
Sbjct: 841 PGRKEEGFSGWKLDYGEWSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT 900
Query: 879 EKPPARKKSGHPAPSSMRSRGGVWR 903
EKPPARKKSGHPAPSSMRSRGGVWR
Sbjct: 901 EKPPARKKSGHPAPSSMRSRGGVWR 925
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 107 bits (266), Expect = 7e-23
Identities = 99/394 (25%), Positives = 182/394 (46%), Gaps = 25/394 (6%)
Query: 181 PDFQGLR--DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKT 238
PD + LR + L+ R+ ++ + Q RV + +++ RK++T++ + ++
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW-----RKRETVLRKEEEK 259
Query: 239 LARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQES 298
L R E E LR L+ + E +QQ+ R EQ L E REQ+
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358
R +Q+ER +EER+ LR E E++R L+ E++ E RE + R EE
Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQE-------EERREQQLRREQEEER 372
Query: 359 RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGE 418
R+ ++E QL+ Q +E+ + ++ + + Q + + QL Q R E E
Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Query: 419 LDTARRERDALQLEMSLVQARYESQR--IQLESELAVQLEQRVTERLAQAQESSLRQA-A 475
+ E++ + + Q E +R ++ E E ++R ++L + QE R+
Sbjct: 433 RHEQKHEQERREQRLKREQ---EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 476 SLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER-QQQVAEDYELRLAREQARVCE 534
L E R++ Q+ Q + + + +++ E EER QQ++ + +LR +E+ R
Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 535 LQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568
L ++ EE+R+E R Q + + + +QLL
Sbjct: 550 L----KREEEKRLEQERREQRLKREQEERRDQLL 579
Score = 97.4 bits (241), Expect = 5e-20
Identities = 116/464 (25%), Positives = 192/464 (41%), Gaps = 53/464 (11%)
Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
+ EE + T LQ+ P + EE L + Q LR
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE----------EEQLRKLERQELRR 288
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
E +++ R Q + + E ++Q +++ E+ ++ L R
Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR------E 342
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET 308
E R + LR QEE + + R +Q+E R EQ L + L REQ+ R QQ RE
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEE--RREQQLRREQQ-LRREQQLRREQQLRREQ 399
Query: 309 LEEERQALT----LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQ 364
Q L LR E + +R L+ E++ R Q E E +EER+ W +
Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Query: 365 QEHQLKEHYQAL--------QEESQAQ----LEREKEKSQREAQAAWETQHQLALVQSEV 412
+E + + H Q QEE + + LE E+ + Q+E + + Q + +
Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR 472
+R E E R + L+ E L + + E + L+ E +LEQ E+ + ++ R
Sbjct: 520 KRQEEE----ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575
Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAR----- 527
RE R+Q Q L + ++ L +L + +VE E+EER++Q + E R
Sbjct: 576 DQLLKREEERRQ-QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634
Query: 528 -----EQARVCELQSGNQQLEEQRV---ELVERLQAMLQAHWDE 563
E+ R +L+ Q+ EQR+ E ERL+ L+ +E
Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678
Score = 89.0 bits (219), Expect = 2e-17
Identities = 102/381 (26%), Positives = 168/381 (44%), Gaps = 36/381 (9%)
Query: 184 QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243
Q R L+ E RR+H +L + LQ+QL RK+ ++++ ++ L R
Sbjct: 872 QKWRWQLEEERKRRRH------TLYAKPA-LQEQL-------RKEQQLLQEEEEELQRE- 916
Query: 244 EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ 303
R + R E R +EE Q + ++E + R E+ E + ++ +LQQ
Sbjct: 917 ---EREKRRRQEQERQYREEEQLQQ-----EEEQLLREEREKRRRQERERQYRKDKKLQQ 968
Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
+E + L EE + R E+++ +EE L E RE R E ERQ
Sbjct: 969 KEEQLLGEEPEK---RRRQEREKKYREEEELQQEEEQLLREEREK---RRRQEWERQYRK 1022
Query: 364 QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423
+ E Q +E Q L+EE + + +E+E+ RE + + + QL + E RR + R
Sbjct: 1023 KDELQQEEE-QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081
Query: 424 RERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK 483
+E + Q E L++ E +R Q + + R E L Q +E LR+ R
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQER-----ERQCREEEELQQEEEQLLREEREKRRRQEL 1136
Query: 484 QLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLE 543
+ Q + Q+ QL + + E R+E ++Q E+ EL+ EQ E + Q+ E
Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196
Query: 544 EQ-RVELVERLQAMLQAHWDE 563
Q R E + Q Q + DE
Sbjct: 1197 RQYREEEELQRQKRKQRYRDE 1217
Score = 88.6 bits (218), Expect = 2e-17
Identities = 115/433 (26%), Positives = 194/433 (44%), Gaps = 59/433 (13%)
Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADR----------KKDTMIEQLD 236
R+ + H ++ ER Q L+ E + L +R K+D E+ +
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486
Query: 237 KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQ 296
+ L E + R + LR QEE + L R +++E RL+Q L + L REQ
Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE---RLQQRLRSEQQ-LRREQ 542
Query: 297 ESAR--LQQRERE-TLEEERQALTLRLEAEQQRCCVL--QEERDAARAGQLSEHR----- 346
E R L +RE E LE+ER+ L+ E E++R +L +EER R + E R
Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 347 -ELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQL 405
E R EE R+ ++E +E Q L +S+ Q ER +++ +RE Q E + Q
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLL-KSEEQEERRQQQLRREQQ---ERREQR 658
Query: 406 ALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ 465
+ E RLE L +RE + + E L + E R +++S + Q +E A
Sbjct: 659 LKREEEEERLEQRL---KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE--AD 713
Query: 466 AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
A++S + +E R++ + + ++E S+L + E A R++++++ D+ +
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRE--SELQWQEEERAHRQQQEEEQRRDFTWQW 771
Query: 526 AREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPS 585
E+ + + G Q+L R L E+ + L+A +E Q L
Sbjct: 772 QAEE----KSERGRQRL-SARPPLREQRERQLRA--EERQQREQRFL------------- 811
Query: 586 SPGPQEPEKEERR 598
P+E EKE+RR
Sbjct: 812 ---PEEEEKEQRR 821
Score = 87.0 bits (214), Expect = 7e-17
Identities = 89/382 (23%), Positives = 162/382 (42%), Gaps = 35/382 (9%)
Query: 191 DSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHE 250
+ E ++ +R + + + LE ++QL R++ +++ + L E E
Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQ-----RRERAQQLQEEEDGLQEDQERRRSQE 867
Query: 251 AERTEVLRG-LQEEHQAAELT---RSKQQETVTRLEQSLSEAMEALNREQ---------- 296
R + R L+EE + T + QE + + +Q L E E L RE+
Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 297 ----ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLR 352
E +LQQ E + L EER+ + Q R ++++ G+ E R
Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR----- 982
Query: 353 AALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEV 412
+E + + ++E +E Q L+EE + + +E E+ R+ + + QL + E
Sbjct: 983 --RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR 472
RRL+ R E + Q E L+ E++R Q ++ + R E L Q +E LR
Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQ-----ELERQYRKEEELQQEEEQLLR 1095
Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
+ R ++ Q + Q+ QL + + E R+E ++Q E+ E++ EQ
Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155
Query: 533 CELQSGNQQLEEQRVELVERLQ 554
E + +Q E++ E LQ
Sbjct: 1156 EEPEKRRRQELERQYREEEELQ 1177
Score = 82.0 bits (201), Expect = 2e-15
Identities = 133/539 (24%), Positives = 208/539 (38%), Gaps = 75/539 (13%)
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQL-----------QTMLQTSRDTAYRDP 121
Q L R LE+ LK+++ + E E R Q Q +L++ R
Sbjct: 588 QRLKREQEERLEQRLKREEVER--LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645
Query: 122 LIPGAGSERRE--------EDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLR 173
+ ERRE E+ + R Q+L+ QA E + R
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI---- 701
Query: 174 PGPPLNPPDFQGLRDALDSE-HTRRKHCE----RHIQSLQTRVLELQQQLAVAVAADRKK 228
P + DA S+ ++R + E R Q + R E + Q A R++
Sbjct: 702 ---PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758
Query: 229 DTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEA 288
++ D T W E++E RG Q L ++++ Q +
Sbjct: 759 QEEEQRRDFT-------WQWQAEEKSE--RGRQRLSARPPLREQRERQLRAEERQQREQR 809
Query: 289 MEALNREQESARLQQRERET----LEEERQALTLRLEAEQQRCCVLQEERDAARAGQ--- 341
E+E R Q+RERE LEEE Q L R A+Q LQEE D + Q
Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQ-----LQEEEDGLQEDQERR 863
Query: 342 -LSEHRELETLRAALEEERQTWAQQ-------EHQLKEHYQALQEESQAQLEREKEKSQR 393
E R + R LEEER+ + QL++ Q LQEE + +L+RE+ + +R
Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-ELQREEREKRR 922
Query: 394 EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV 453
+ + + + L Q E + L E + RR+ Q + E Q + E E
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 454 QLEQ----RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
+ E+ R E L Q +E LR+ R + Q Q+ QL + + E
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568
+ER++Q E+ EL+ EQ ++ E +R + +ER + E QLL
Sbjct: 1043 LQERERQYREEEELQQEEEQLL-------GEERETRRRQELERQYRKEEELQQEEEQLL 1094
Score = 81.6 bits (200), Expect = 3e-15
Identities = 90/334 (26%), Positives = 150/334 (44%), Gaps = 20/334 (5%)
Query: 190 LDSEHTRRKHCERHIQS--LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247
L+ + RR+ ER Q R E QQQL +++D + D+ L + E
Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR------QERDRKFRE-DEQLLQEREEQQ 1635
Query: 248 RHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERE 307
H ER + L+EE Q R +QQ R + E E++ R Q+R+R+
Sbjct: 1636 LHRQERDR--KFLEEEPQLRRQER-EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692
Query: 308 TLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEH 367
EEE+Q L +++ LQEE+ R + RE E LR E+E+ ++
Sbjct: 1693 FREEEQQ-----LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Query: 368 QLKEHYQALQEESQAQLER-EKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426
++ E Q E + QL R E+++ RE + + + + L E R E + R+ER
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Query: 427 DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486
+ QL +Y + QL+ E Q ++ +R +A+E Q S RE ++ Q
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE-QELWQ 1866
Query: 487 DLSGQHQQELASQLAQFKVEMAEREE-RQQQVAE 519
+ + +QE +L + + ++EE R +QV E
Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQRHRQVGE 1900
Score = 78.2 bits (191), Expect = 3e-14
Identities = 109/405 (26%), Positives = 175/405 (43%), Gaps = 59/405 (14%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E +R+ ER + + ELQQ+ + +R+K R + W R
Sbjct: 974 LGEEPEKRRRQEREKKYREEE--ELQQEEEQLLREEREK------------RRRQEWERQ 1019
Query: 250 EAERTEVLRGLQEEHQAAELTRSK----QQETVTRLEQSLSEAMEAL-NREQESARLQQR 304
++ E+ QEE Q R K ++E R E+ L + E L E+E+ R Q+
Sbjct: 1020 YRKKDELQ---QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 305 ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAAL-EEERQT-- 361
ER+ +EE L+ E EQ ++ R R Q E EL+ L EER+
Sbjct: 1077 ERQYRKEEE----LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132
Query: 362 -------WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRR 414
+ ++E +E Q L+EE + + +E E+ RE + + + QL + E RR
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 415 LEGELDTARRERDALQLEMSLVQARYESQRIQL------ESELAVQ-----LEQRVTERL 463
E E RE + LQ + + R E QR L E E AV+ + R E+
Sbjct: 1193 QERE--RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250
Query: 464 AQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYEL 523
Q ++S LR S ++ LQ L G+ QQE + + + + +R +++ E E
Sbjct: 1251 RQLEDSQLRDRQS-----QQDLQHLLGE-QQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Query: 524 RLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568
+ A+ + R + Q Q L E+R E +R + + E QLL
Sbjct: 1305 KEAKRRDR--KSQEEKQLLREEREE--KRRRQETDRKFREEEQLL 1345
Score = 77.8 bits (190), Expect = 4e-14
Identities = 110/443 (24%), Positives = 194/443 (43%), Gaps = 80/443 (18%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E +H ++H Q + + L+ +Q+ ++D + + E RH
Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQE--------ERRDWLKRE---------EETERH 467
Query: 250 EAERT-EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET 308
E ER + L+ QEE + + +++E R +Q E + L REQE R +QR +
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEER--REQQERRE--QQLRREQEERR-EQRLKRQ 522
Query: 309 LEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
EEER L RL +EQQ L+ E++ R E L EE+R ++E +
Sbjct: 523 EEEER--LQQRLRSEQQ----LRREQEERR----------EQLLKREEEKRLEQERREQR 566
Query: 369 LKEHYQALQEESQAQ-LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARR-ER 426
LK QEE + Q L+RE+E+ Q+ + E + + L + EV RLE E +R +R
Sbjct: 567 LKRE----QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622
Query: 427 DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486
+ + E + E Q + + +L + ++R +RL + +E + REH ++ +
Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682
Query: 487 DLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQR 546
+ +QE A + + ++ + Q Q+ + + R ++ +R Q G ++ +EQ
Sbjct: 683 QELAEEEQEQARERIKSRI-----PKWQWQLESEADARQSKVYSRP-RKQEGQRRRQEQE 736
Query: 547 VELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMA 606
E R ++ LQ W E + Q+ E+E+RR +T A
Sbjct: 737 -EKRRRRESELQ--WQEEER--------------------AHRQQQEEEQRRDFTWQWQA 773
Query: 607 VALKPVLQQSREARDELPGAPPV 629
++S R L PP+
Sbjct: 774 E------EKSERGRQRLSARPPL 790
Score = 77.4 bits (189), Expect = 6e-14
Identities = 91/389 (23%), Positives = 160/389 (41%), Gaps = 38/389 (9%)
Query: 184 QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243
Q L+ L + R + ER + R ++QL + K+ Q +K L R
Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324
Query: 244 EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ 303
R R E R +EE Q L + ++++ + R E+ E L +++ + +
Sbjct: 1325 REEKRR---RQETDRKFREEEQ---LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378
Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ +ER+ L+ E +Q RC +ER+ QL + R+ + EE Q +
Sbjct: 1379 EEQRLRRQERERKFLK-EEQQLRC----QEREQ----QLRQDRDRK-----FREEEQQLS 1424
Query: 364 QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423
+QE K +EE Q + + + K E Q + +H+ + ++ + E R
Sbjct: 1425 RQERDRKFR----EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480
Query: 424 RERDALQLEMSLVQARYESQRIQLESELAVQ------LEQRVTERLAQAQESSLRQAASL 477
+ERD LE R E R E EL Q LE+ Q Q L++ L
Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540
Query: 478 RE----HHRKQLQDLSGQHQQELASQLAQFKVEMAEREER----QQQVAEDYELRLAREQ 529
R R+Q +D + +++L + + ++ ER+ + +Q+V + R E
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 530 ARVCELQSGNQQLEEQRVELVERLQAMLQ 558
+ Q G QQL ++R + +LQ
Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629
Score = 75.9 bits (185), Expect = 2e-13
Identities = 103/404 (25%), Positives = 167/404 (41%), Gaps = 46/404 (11%)
Query: 190 LDSEHTRRKHCER----HIQSLQTRVLELQQQLAVAVAAD----------RKKDTMIEQL 235
L S+ RK E H Q Q + L+ +QQL R+++ + ++
Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567
Query: 236 DKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAM---EAL 292
++ E + E +V R QE + + ++QE +L Q E L
Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 293 NREQESARL--QQRERETLEEERQALTLRLEAEQQ----RCCVLQEERDAARAGQLSEHR 346
+E+E +L Q+R+R+ LEEE Q R E EQQ R +EE + G+ + R
Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLR--RQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685
Query: 347 ELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLA 406
E R EEE+Q Q+ + + LQEE Q + + + K + E Q ET+ +
Sbjct: 1686 RQERDRKFREEEQQLRRQERER-----KFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740
Query: 407 LVQSEVRRL-----------EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
Q R++ E +L R+R + E L Q R E Q ES+ +
Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDR-KFREEEQLRQEREEQQLRSQESDRKFRE 1799
Query: 456 EQRV-TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQL---AQFKVEMAERE 511
E+++ ER Q R E + QL++ + +QE Q QF + R
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 512 ERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQA 555
E Q+ E+ + R + ++ E QQ EEQR V +++
Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903
Score = 74.3 bits (181), Expect = 5e-13
Identities = 104/410 (25%), Positives = 175/410 (42%), Gaps = 54/410 (13%)
Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
R L+ E R+ R + + + E ++Q DRK +QL +
Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ-------- 1497
Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306
R R + LR + E + E +Q R + L E + +E+ R Q R+R
Sbjct: 1498 ERDRKFREQELRSQEPERKFLE--EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Query: 307 ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE 366
+ EEE+ LR E E+Q+ + ++ERD + + R E R +E+E+Q Q+
Sbjct: 1556 KFREEEQ----LRQEREEQQ--LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609
Query: 367 HQ---------LKEHYQALQEESQAQLER--------EKEKSQREAQAAWETQHQLALVQ 409
Q +E Q LQE + QL R E+E R + + +H
Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669
Query: 410 SEVRRL--EGELDTARR-ERDALQLEMSLVQARYESQR--IQLESELAVQLEQRVTERLA 464
E +L EGE RR ERD E R E +R +Q E +L Q +R
Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729
Query: 465 QAQESSLRQAASLREHHRKQLQD---LSGQHQQELASQL--AQFKVEMAEREERQQQ--- 516
Q ++ + ++ +E +RK L++ + +Q+L Q +F+ E R+ER++Q
Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789
Query: 517 -------VAEDYELRLAREQARVCELQ-SGNQQLEEQRVELVERLQAMLQ 558
E+ +LR RE+ ++ Q G + EE++++L E+ Q + Q
Sbjct: 1790 SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Score = 73.2 bits (178), Expect = 1e-12
Identities = 97/412 (23%), Positives = 174/412 (42%), Gaps = 56/412 (13%)
Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
+D L E + ER + LQ R + R+++ + ++ ++ L E
Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQY-----------REEEELQQEEEQLLGEERETR 1071
Query: 247 NRHEAERT----EVLRGLQEE--HQAAELTRSKQQETVTRLEQSLSEAMEALNREQ-ESA 299
R E ER E L+ +E+ + E R +++E R E+ L + E L RE+ E
Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131
Query: 300 RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLS-EHRELETLRAALEEE 358
R Q+ ER+ EEE E +Q+ +L+EE + R +L ++RE E L+ EEE
Sbjct: 1132 RRQELERQYREEE--------EVQQEEEQLLREEPEKRRRQELERQYREEEELQQ--EEE 1181
Query: 359 RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAA-----WETQHQLALVQSEV- 412
+ +QE + +E + +EE + Q ++ K++ + E Q + WE + + A+ ++V
Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241
Query: 413 ---------RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV---------Q 454
R+LE D+ R+R + Q L+ + E R Q Q
Sbjct: 1242 CKGRENEQFRQLE---DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ 1298
Query: 455 LEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQ 514
LE+ + + S + LRE ++ + + QL Q + E R + +
Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358
Query: 515 QQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
+ + ELR + + E + ++ E +R L E Q Q + Q
Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410
Score = 72.0 bits (175), Expect = 2e-12
Identities = 79/345 (22%), Positives = 142/345 (41%), Gaps = 43/345 (12%)
Query: 259 GLQEEHQAA-----ELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313
GL EE +A L + ++QE R + +E ++ + Q++ERE E E
Sbjct: 94 GLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153
Query: 314 QA----------------------------LTLRLEAEQQRCCVLQEERDAARAGQLSEH 345
Q+ R E EQ + C E + QL
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213
Query: 346 RELETLRAALEE-ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQ 404
LE R EE ++Q +Q+ +E + + + L +E+EK Q E E Q Q
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE-----EPQRQ 268
Query: 405 LALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLA 464
L + E + + E RRER + + ++ + +R Q E E Q E+R ++
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ-EEERREQQEERREQQER 327
Query: 465 QAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREE---RQQQVAEDY 521
+ Q+ R+ RE ++ Q L + ++E Q + + E RE+ R+QQ+ +
Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387
Query: 522 ELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
+LR ++ R +L+ Q EQ++ ++L+ Q ++ +
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432
Score = 57.8 bits (138), Expect = 5e-08
Identities = 114/508 (22%), Positives = 200/508 (39%), Gaps = 76/508 (14%)
Query: 69 DGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGS 128
D QE + L EK + ++ + E E ++ + + +L R+T R L
Sbjct: 1024 DELQQEEEQLLREEREKR-RLQERERQYREEEELQQEEEQLLGEERETRRRQEL----ER 1078
Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
+ R+E+ + LL P + Q EE L + Q LR+
Sbjct: 1079 QYRKEEELQQEEEQ-LLREEPEKRRRQERERQCREE-----------EELQQEEEQLLRE 1126
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTM---------IEQLDKTL 239
+ E RR+ ER + + V + ++QL R++ + ++Q ++ L
Sbjct: 1127 --EREKRRRQELERQYRE-EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Query: 240 ARVVEGWNRHEAERT-----EVLRGLQEEHQAAELTRS--KQQETVTRLEQSLSEAMEAL 292
R + R E ER E+ R +++ E RS K Q + +
Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243
Query: 293 NREQESARL----QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHREL 348
RE E R Q R+R++ ++ + L EQQ ERD
Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLL-----GEQQ-------ERDR------------ 1279
Query: 349 ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408
E+ER+ W Q++ E Q L+ E Q + +R KSQ E Q E + +
Sbjct: 1280 -------EQERRRWQQRDRHFPEEEQ-LEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 409 QSEVRRL-EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQ 467
Q R+ E E RE L+ + + R E R Q + ++ EQR+ R + +
Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL--RRQERE 1389
Query: 468 ESSLRQAASLR-EHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLA 526
L++ LR + +QL+ + +E QL++ + + REE QQ ++ E +
Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFL 1449
Query: 527 REQARVCELQSGNQQLEEQRVELVERLQ 554
E+ ++ + + + EEQ ++ E Q
Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Score = 55.8 bits (133), Expect = 2e-07
Identities = 57/273 (20%), Positives = 117/273 (42%), Gaps = 18/273 (6%)
Query: 297 ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE 356
++ L + +R + + L R + E QR ++ + GQ + E R E
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150
Query: 357 EERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWETQHQLALVQSEVR 413
E Q+ Q+ + ++ + +E + Q ERE+ +++ E + + E
Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210
Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473
R L+ R+ R+ Q Q R R+ E E + E R E + + +E L++
Sbjct: 211 RRRELLELRRKGREEKQ-----QQRRERQDRVFQEEE---EKEWRKRETVLRKEEEKLQE 262
Query: 474 AASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVC 533
R+ ++L + +Q + + + E E E++QQ++ + +LR +E+ R
Sbjct: 263 EEPQRQ------RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER-R 315
Query: 534 ELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
E Q ++ +E+R + ER + L+ +E +
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERRE 348
Score = 37.0 bits (84), Expect = 0.083
Identities = 48/178 (26%), Positives = 78/178 (43%), Gaps = 18/178 (10%)
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRK---KDTMIEQLDKTLARV 242
LR + E RR+ R I + E ++Q DRK ++ + ++ ++ R
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Query: 243 VEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL- 301
E + E E LR +EE Q R +Q++ R E+ E L E++ RL
Sbjct: 1791 QESDRKFREE--EQLRQEREEQQL----RPQQRDGKYRWEE------EQLQLEEQEQRLR 1838
Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER 359
Q+R+R+ EE+ A + E+Q + QEE R + + RE R EE+R
Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQE--LWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 104 bits (259), Expect = 4e-22
Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2129
Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
Q + + + AL+++ A E EK K +++AQ E
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2367
Query: 557 LQA 559
L+A
Sbjct: 2368 LEA 2370
Score = 103 bits (256), Expect = 9e-22
Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1466
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
L+ L+ + AE + + QE RL + + E + E E
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
+AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+
Sbjct: 1527 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
+R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R +
Sbjct: 1581 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1635
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
+ +AL+L + + + Q E+E + +R R +A+E ++RQ
Sbjct: 1636 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690
Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+ KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A +
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
+ Q+LE + ++ ++ +L + + ST S Q E E
Sbjct: 1750 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1792
Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620
R + A L+ + ++++ R
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQR 1817
Score = 87.4 bits (215), Expect = 5e-17
Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)
Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
GAE++L E Q +L A+ ++ A A AQ D
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1150
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
EL + VG + L+++ G + + E+E R ++ +L+ + T R + G
Sbjct: 1151 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
+ R A L + R Q+ P + +QA+ E + Q
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1253
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
L + ++ + + C+R + + + + QL VA+ KK + + +
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313
Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
V+ H +E T E LR ++EE + AE R++++E + +E +L +
Sbjct: 1314 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372
Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
A E+E+ LQQR +E + +A ++A+QQ+ + +E
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1429
Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
+ +AA +L E+ +R LE + E +L+ +A EE++AQ
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1488
Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
+ +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
+R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A
Sbjct: 1549 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1604
Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA
Sbjct: 1605 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1648
Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
+E Q S + +E E+E RR AV + + +Q E +
Sbjct: 1649 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
+L G ++ +L L + Q + Q LE
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)
Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
+RQAEA R++L + +E R + + LE +++ G++ E++++R
Sbjct: 1437 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1480
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
+ + R + + + A+ + + QALEE
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
L R + L + + R + T ++ E +QS + E QL
Sbjct: 1541 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
VAVA A+R+ + E+ + R +E W + + E LR + + A+
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1655
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
Q E + E++ EA E+++ R ++ + LE++RQ
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715
Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
+ LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + +
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1773
Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
+E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ +
Sbjct: 1774 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1882
Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ +
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 548 EL 549
EL
Sbjct: 1943 EL 1944
Score = 85.9 bits (211), Expect = 2e-16
Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
ELQ+ A A A R++ + E+L R + E L+ E A + R
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2258
Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K QE +++Q EA QE+ARL+Q E L ++R L+ + Q
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2317
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL
Sbjct: 2318 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
E R +E +QR + A E TQ ++ LVQ+ E+
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
+R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2495
Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
L + SL + R +QL++ + QQ++ + + M E
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2614
Query: 564 --ANQLLST-TLP 573
A+Q+ +T TLP
Sbjct: 2615 VTASQVAATKTLP 2627
Score = 67.4 bits (163), Expect = 6e-11
Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)
Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
Q+QLA AA R++ L + LA + E + EAE E LR L E+
Sbjct: 1816 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
R + +E + + + E + L + +S +Q R+R +EEE AL
Sbjct: 1875 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
E A AG+ EL +R+ E+ ++ Q E + Q
Sbjct: 1932 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977
Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L
Sbjct: 1978 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2095
Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R Q + + Q Q E A +L Q E A+ + Q AE +E AR
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2148
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q E+ + + A ++ H A Q L
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Score = 67.4 bits (163), Expect = 6e-11
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E + K L E + +A ++ + E++ K + V+ R
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
+AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E +
Sbjct: 2326 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2378
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
E + L LR+ AE R EE DA R + +E + R L +E+ T Q
Sbjct: 2379 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
+ Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + +
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
R+Q L+ Q ++ LA + + + ++ EE+ + E
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Query: 526 AREQARVCELQSGNQQLEEQRVE 548
A + A L +G L+ E
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAE 2639
Score = 39.7 bits (91), Expect = 0.013
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)
Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
+E Q RLEA+ Q L + + R QL L T R EE+
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922
Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
+ Q H L+ HYQA +SQ ERE Q ++ Q A +
Sbjct: 923 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+
Sbjct: 980 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1033
Query: 469 SSL 471
L
Sbjct: 1034 EGL 1036
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 104 bits (259), Expect = 4e-22
Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV
Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015
Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++
Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075
Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A
Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2133
Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
Q + + + AL+++ A E EK K +++AQ E
Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193
Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+
Sbjct: 2194 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2253
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA
Sbjct: 2254 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313
Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q
Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2371
Query: 557 LQA 559
L+A
Sbjct: 2372 LEA 2374
Score = 103 bits (256), Expect = 9e-22
Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1470
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
L+ L+ + AE + + QE RL + + E + E E
Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
+AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+
Sbjct: 1531 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584
Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
+R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R +
Sbjct: 1585 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1639
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
+ +AL+L + + + Q E+E + +R R +A+E ++RQ
Sbjct: 1640 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1694
Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+ KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A +
Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1753
Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
+ Q+LE + ++ ++ +L + + ST S Q E E
Sbjct: 1754 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1796
Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620
R + A L+ + ++++ R
Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQR 1821
Score = 87.4 bits (215), Expect = 5e-17
Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)
Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
GAE++L E Q +L A+ ++ A A AQ D
Sbjct: 1104 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1154
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
EL + VG + L+++ G + + E+E R ++ +L+ + T R + G
Sbjct: 1155 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211
Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
+ R A L + R Q+ P + +QA+ E + Q
Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1257
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
L + ++ + + C+R + + + + QL VA+ KK + + +
Sbjct: 1258 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1317
Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
V+ H +E T E LR ++EE + AE R++++E + +E +L +
Sbjct: 1318 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1376
Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
A E+E+ LQQR +E + +A ++A+QQ+ + +E
Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1433
Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
+ +AA +L E+ +R LE + E +L+ +A EE++AQ
Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1492
Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
+ +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA
Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
+R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A
Sbjct: 1553 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1608
Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA
Sbjct: 1609 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1652
Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
+E Q S + +E E+E RR AV + + +Q E +
Sbjct: 1653 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702
Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
+L G ++ +L L + Q + Q LE
Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)
Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
+RQAEA R++L + +E R + + LE +++ G++ E++++R
Sbjct: 1441 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1484
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
+ + R + + + A+ + + QALEE
Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
L R + L + + R + T ++ E +QS + E QL
Sbjct: 1545 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602
Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
VAVA A+R+ + E+ + R +E W + + E LR + + A+
Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1659
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
Q E + E++ EA E+++ R ++ + LE++RQ
Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719
Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
+ LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + +
Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1777
Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
+E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ +
Sbjct: 1778 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++
Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1886
Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ +
Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946
Query: 548 EL 549
EL
Sbjct: 1947 EL 1948
Score = 85.9 bits (211), Expect = 2e-16
Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
ELQ+ A A A R++ + E+L R + E L+ E A + R
Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2262
Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K QE +++Q EA QE+ARL+Q E L ++R L+ + Q
Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2321
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL
Sbjct: 2322 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380
Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
E R +E +QR + A E TQ ++ LVQ+ E+
Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
+R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2499
Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
L + SL + R +QL++ + QQ++ + + M E
Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559
Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E
Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2618
Query: 564 --ANQLLST-TLP 573
A+Q+ +T TLP
Sbjct: 2619 VTASQVAATKTLP 2631
Score = 67.4 bits (163), Expect = 6e-11
Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)
Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
Q+QLA AA R++ L + LA + E + EAE E LR L E+
Sbjct: 1820 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878
Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
R + +E + + + E + L + +S +Q R+R +EEE AL
Sbjct: 1879 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
E A AG+ EL +R+ E+ ++ Q E + Q
Sbjct: 1936 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1981
Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L
Sbjct: 1982 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040
Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E
Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2099
Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R Q + + Q Q E A +L Q E A+ + Q AE +E AR
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2152
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q E+ + + A ++ H A Q L
Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182
Score = 67.4 bits (163), Expect = 6e-11
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E + K L E + +A ++ + E++ K + V+ R
Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
+AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E +
Sbjct: 2330 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2382
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
E + L LR+ AE R EE DA R + +E + R L +E+ T Q
Sbjct: 2383 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440
Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
+ Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + +
Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500
Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560
Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
R+Q L+ Q ++ LA + + + ++ EE+ + E
Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620
Query: 526 AREQARVCELQSGNQQLEEQRVE 548
A + A L +G L+ E
Sbjct: 2621 ASQVAATKTLPNGRDALDGPAAE 2643
Score = 39.7 bits (91), Expect = 0.013
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)
Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
+E Q RLEA+ Q L + + R QL L T R EE+
Sbjct: 867 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 926
Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
+ Q H L+ HYQA +SQ ERE Q ++ Q A +
Sbjct: 927 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 983
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+
Sbjct: 984 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1037
Query: 469 SSL 471
L
Sbjct: 1038 EGL 1040
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 104 bits (259), Expect = 4e-22
Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV
Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011
Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++
Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071
Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A
Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2129
Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
Q + + + AL+++ A E EK K +++AQ E
Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189
Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+
Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA
Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309
Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q
Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2367
Query: 557 LQA 559
L+A
Sbjct: 2368 LEA 2370
Score = 103 bits (256), Expect = 9e-22
Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1466
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
L+ L+ + AE + + QE RL + + E + E E
Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
+AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+
Sbjct: 1527 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
+R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R +
Sbjct: 1581 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1635
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
+ +AL+L + + + Q E+E + +R R +A+E ++RQ
Sbjct: 1636 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690
Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+ KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A +
Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1749
Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
+ Q+LE + ++ ++ +L + + ST S Q E E
Sbjct: 1750 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1792
Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620
R + A L+ + ++++ R
Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQR 1817
Score = 87.4 bits (215), Expect = 5e-17
Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)
Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
GAE++L E Q +L A+ ++ A A AQ D
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1150
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
EL + VG + L+++ G + + E+E R ++ +L+ + T R + G
Sbjct: 1151 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207
Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
+ R A L + R Q+ P + +QA+ E + Q
Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1253
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
L + ++ + + C+R + + + + QL VA+ KK + + +
Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313
Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
V+ H +E T E LR ++EE + AE R++++E + +E +L +
Sbjct: 1314 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372
Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
A E+E+ LQQR +E + +A ++A+QQ+ + +E
Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1429
Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
+ +AA +L E+ +R LE + E +L+ +A EE++AQ
Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1488
Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
+ +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA
Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
+R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A
Sbjct: 1549 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1604
Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA
Sbjct: 1605 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1648
Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
+E Q S + +E E+E RR AV + + +Q E +
Sbjct: 1649 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698
Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
+L G ++ +L L + Q + Q LE
Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)
Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
+RQAEA R++L + +E R + + LE +++ G++ E++++R
Sbjct: 1437 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1480
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
+ + R + + + A+ + + QALEE
Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
L R + L + + R + T ++ E +QS + E QL
Sbjct: 1541 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598
Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
VAVA A+R+ + E+ + R +E W + + E LR + + A+
Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1655
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
Q E + E++ EA E+++ R ++ + LE++RQ
Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715
Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
+ LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + +
Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1773
Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
+E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ +
Sbjct: 1774 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++
Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1882
Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ +
Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942
Query: 548 EL 549
EL
Sbjct: 1943 EL 1944
Score = 85.9 bits (211), Expect = 2e-16
Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
ELQ+ A A A R++ + E+L R + E L+ E A + R
Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2258
Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K QE +++Q EA QE+ARL+Q E L ++R L+ + Q
Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2317
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL
Sbjct: 2318 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376
Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
E R +E +QR + A E TQ ++ LVQ+ E+
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
+R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2495
Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
L + SL + R +QL++ + QQ++ + + M E
Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555
Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E
Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2614
Query: 564 --ANQLLST-TLP 573
A+Q+ +T TLP
Sbjct: 2615 VTASQVAATKTLP 2627
Score = 67.4 bits (163), Expect = 6e-11
Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)
Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
Q+QLA AA R++ L + LA + E + EAE E LR L E+
Sbjct: 1816 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874
Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
R + +E + + + E + L + +S +Q R+R +EEE AL
Sbjct: 1875 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
E A AG+ EL +R+ E+ ++ Q E + Q
Sbjct: 1932 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977
Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L
Sbjct: 1978 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036
Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E
Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2095
Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R Q + + Q Q E A +L Q E A+ + Q AE +E AR
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2148
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q E+ + + A ++ H A Q L
Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178
Score = 67.4 bits (163), Expect = 6e-11
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E + K L E + +A ++ + E++ K + V+ R
Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
+AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E +
Sbjct: 2326 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2378
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
E + L LR+ AE R EE DA R + +E + R L +E+ T Q
Sbjct: 2379 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436
Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
+ Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + +
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496
Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556
Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
R+Q L+ Q ++ LA + + + ++ EE+ + E
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616
Query: 526 AREQARVCELQSGNQQLEEQRVE 548
A + A L +G L+ E
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAE 2639
Score = 39.7 bits (91), Expect = 0.013
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)
Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
+E Q RLEA+ Q L + + R QL L T R EE+
Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922
Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
+ Q H L+ HYQA +SQ ERE Q ++ Q A +
Sbjct: 923 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+
Sbjct: 980 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1033
Query: 469 SSL 471
L
Sbjct: 1034 EGL 1036
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 104 bits (259), Expect = 4e-22
Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV
Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979
Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++
Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039
Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A
Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2097
Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
Q + + + AL+++ A E EK K +++AQ E
Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157
Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+
Sbjct: 2158 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2217
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA
Sbjct: 2218 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277
Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q
Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2335
Query: 557 LQA 559
L+A
Sbjct: 2336 LEA 2338
Score = 103 bits (256), Expect = 9e-22
Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1434
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
L+ L+ + AE + + QE RL + + E + E E
Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
+AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+
Sbjct: 1495 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548
Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
+R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R +
Sbjct: 1549 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1603
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
+ +AL+L + + + Q E+E + +R R +A+E ++RQ
Sbjct: 1604 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1658
Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+ KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A +
Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1717
Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
+ Q+LE + ++ ++ +L + + ST S Q E E
Sbjct: 1718 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1760
Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620
R + A L+ + ++++ R
Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQR 1785
Score = 87.4 bits (215), Expect = 5e-17
Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)
Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
GAE++L E Q +L A+ ++ A A AQ D
Sbjct: 1068 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1118
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
EL + VG + L+++ G + + E+E R ++ +L+ + T R + G
Sbjct: 1119 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175
Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
+ R A L + R Q+ P + +QA+ E + Q
Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1221
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
L + ++ + + C+R + + + + QL VA+ KK + + +
Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281
Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
V+ H +E T E LR ++EE + AE R++++E + +E +L +
Sbjct: 1282 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1340
Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
A E+E+ LQQR +E + +A ++A+QQ+ + +E
Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1397
Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
+ +AA +L E+ +R LE + E +L+ +A EE++AQ
Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1456
Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
+ +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA
Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
+R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A
Sbjct: 1517 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1572
Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA
Sbjct: 1573 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1616
Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
+E Q S + +E E+E RR AV + + +Q E +
Sbjct: 1617 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666
Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
+L G ++ +L L + Q + Q LE
Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)
Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
+RQAEA R++L + +E R + + LE +++ G++ E++++R
Sbjct: 1405 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1448
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
+ + R + + + A+ + + QALEE
Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
L R + L + + R + T ++ E +QS + E QL
Sbjct: 1509 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566
Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
VAVA A+R+ + E+ + R +E W + + E LR + + A+
Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1623
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
Q E + E++ EA E+++ R ++ + LE++RQ
Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683
Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
+ LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + +
Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1741
Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
+E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ +
Sbjct: 1742 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++
Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1850
Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ +
Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910
Query: 548 EL 549
EL
Sbjct: 1911 EL 1912
Score = 85.9 bits (211), Expect = 2e-16
Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
ELQ+ A A A R++ + E+L R + E L+ E A + R
Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2226
Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K QE +++Q EA QE+ARL+Q E L ++R L+ + Q
Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2285
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL
Sbjct: 2286 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344
Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
E R +E +QR + A E TQ ++ LVQ+ E+
Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
+R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2463
Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
L + SL + R +QL++ + QQ++ + + M E
Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523
Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E
Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2582
Query: 564 --ANQLLST-TLP 573
A+Q+ +T TLP
Sbjct: 2583 VTASQVAATKTLP 2595
Score = 67.4 bits (163), Expect = 6e-11
Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)
Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
Q+QLA AA R++ L + LA + E + EAE E LR L E+
Sbjct: 1784 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842
Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
R + +E + + + E + L + +S +Q R+R +EEE AL
Sbjct: 1843 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
E A AG+ EL +R+ E+ ++ Q E + Q
Sbjct: 1900 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1945
Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L
Sbjct: 1946 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004
Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E
Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2063
Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R Q + + Q Q E A +L Q E A+ + Q AE +E AR
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2116
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q E+ + + A ++ H A Q L
Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146
Score = 67.4 bits (163), Expect = 6e-11
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E + K L E + +A ++ + E++ K + V+ R
Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
+AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E +
Sbjct: 2294 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2346
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
E + L LR+ AE R EE DA R + +E + R L +E+ T Q
Sbjct: 2347 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404
Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
+ Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + +
Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464
Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524
Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
R+Q L+ Q ++ LA + + + ++ EE+ + E
Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584
Query: 526 AREQARVCELQSGNQQLEEQRVE 548
A + A L +G L+ E
Sbjct: 2585 ASQVAATKTLPNGRDALDGPAAE 2607
Score = 39.7 bits (91), Expect = 0.013
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)
Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
+E Q RLEA+ Q L + + R QL L T R EE+
Sbjct: 831 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 890
Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
+ Q H L+ HYQA +SQ ERE Q ++ Q A +
Sbjct: 891 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 947
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+
Sbjct: 948 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1001
Query: 469 SSL 471
L
Sbjct: 1002 EGL 1004
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 104 bits (259), Expect = 4e-22
Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV
Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148
Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++
Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208
Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A
Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2266
Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
Q + + + AL+++ A E EK K +++AQ E
Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326
Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+
Sbjct: 2327 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2386
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA
Sbjct: 2387 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446
Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q
Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2504
Query: 557 LQA 559
L+A
Sbjct: 2505 LEA 2507
Score = 103 bits (256), Expect = 9e-22
Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1603
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
L+ L+ + AE + + QE RL + + E + E E
Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
+AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+
Sbjct: 1664 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717
Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
+R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R +
Sbjct: 1718 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1772
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
+ +AL+L + + + Q E+E + +R R +A+E ++RQ
Sbjct: 1773 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827
Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+ KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A +
Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1886
Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
+ Q+LE + ++ ++ +L + + ST S Q E E
Sbjct: 1887 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1929
Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620
R + A L+ + ++++ R
Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQR 1954
Score = 87.4 bits (215), Expect = 5e-17
Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)
Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
GAE++L E Q +L A+ ++ A A AQ D
Sbjct: 1237 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1287
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
EL + VG + L+++ G + + E+E R ++ +L+ + T R + G
Sbjct: 1288 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344
Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
+ R A L + R Q+ P + +QA+ E + Q
Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1390
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
L + ++ + + C+R + + + + QL VA+ KK + + +
Sbjct: 1391 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1450
Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
V+ H +E T E LR ++EE + AE R++++E + +E +L +
Sbjct: 1451 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1509
Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
A E+E+ LQQR +E + +A ++A+QQ+ + +E
Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1566
Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
+ +AA +L E+ +R LE + E +L+ +A EE++AQ
Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1625
Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
+ +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA
Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
+R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A
Sbjct: 1686 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1741
Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA
Sbjct: 1742 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1785
Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
+E Q S + +E E+E RR AV + + +Q E +
Sbjct: 1786 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835
Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
+L G ++ +L L + Q + Q LE
Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)
Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
+RQAEA R++L + +E R + + LE +++ G++ E++++R
Sbjct: 1574 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1617
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
+ + R + + + A+ + + QALEE
Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
L R + L + + R + T ++ E +QS + E QL
Sbjct: 1678 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735
Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
VAVA A+R+ + E+ + R +E W + + E LR + + A+
Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1792
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
Q E + E++ EA E+++ R ++ + LE++RQ
Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852
Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
+ LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + +
Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1910
Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
+E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ +
Sbjct: 1911 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++
Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 2019
Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ +
Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079
Query: 548 EL 549
EL
Sbjct: 2080 EL 2081
Score = 85.9 bits (211), Expect = 2e-16
Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
ELQ+ A A A R++ + E+L R + E L+ E A + R
Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2395
Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K QE +++Q EA QE+ARL+Q E L ++R L+ + Q
Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2454
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL
Sbjct: 2455 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513
Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
E R +E +QR + A E TQ ++ LVQ+ E+
Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
+R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2632
Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
L + SL + R +QL++ + QQ++ + + M E
Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692
Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E
Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2751
Query: 564 --ANQLLST-TLP 573
A+Q+ +T TLP
Sbjct: 2752 VTASQVAATKTLP 2764
Score = 67.4 bits (163), Expect = 6e-11
Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)
Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
Q+QLA AA R++ L + LA + E + EAE E LR L E+
Sbjct: 1953 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011
Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
R + +E + + + E + L + +S +Q R+R +EEE AL
Sbjct: 2012 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
E A AG+ EL +R+ E+ ++ Q E + Q
Sbjct: 2069 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2114
Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L
Sbjct: 2115 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173
Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E
Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2232
Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R Q + + Q Q E A +L Q E A+ + Q AE +E AR
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2285
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q E+ + + A ++ H A Q L
Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315
Score = 67.4 bits (163), Expect = 6e-11
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E + K L E + +A ++ + E++ K + V+ R
Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
+AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E +
Sbjct: 2463 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2515
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
E + L LR+ AE R EE DA R + +E + R L +E+ T Q
Sbjct: 2516 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573
Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
+ Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + +
Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633
Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693
Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
R+Q L+ Q ++ LA + + + ++ EE+ + E
Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753
Query: 526 AREQARVCELQSGNQQLEEQRVE 548
A + A L +G L+ E
Sbjct: 2754 ASQVAATKTLPNGRDALDGPAAE 2776
Score = 39.7 bits (91), Expect = 0.013
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)
Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
+E Q RLEA+ Q L + + R QL L T R EE+
Sbjct: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1059
Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
+ Q H L+ HYQA +SQ ERE Q ++ Q A +
Sbjct: 1060 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1116
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+
Sbjct: 1117 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1170
Query: 469 SSL 471
L
Sbjct: 1171 EGL 1173
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 104 bits (259), Expect = 4e-22
Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV
Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989
Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++
Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049
Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A
Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2107
Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
Q + + + AL+++ A E EK K +++AQ E
Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167
Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+
Sbjct: 2168 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2227
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA
Sbjct: 2228 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287
Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q
Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2345
Query: 557 LQA 559
L+A
Sbjct: 2346 LEA 2348
Score = 103 bits (256), Expect = 9e-22
Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R
Sbjct: 1386 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1444
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
L+ L+ + AE + + QE RL + + E + E E
Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
+AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+
Sbjct: 1505 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
+R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R +
Sbjct: 1559 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1613
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
+ +AL+L + + + Q E+E + +R R +A+E ++RQ
Sbjct: 1614 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668
Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+ KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A +
Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1727
Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
+ Q+LE + ++ ++ +L + + ST S Q E E
Sbjct: 1728 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1770
Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620
R + A L+ + ++++ R
Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQR 1795
Score = 87.4 bits (215), Expect = 5e-17
Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)
Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
GAE++L E Q +L A+ ++ A A AQ D
Sbjct: 1078 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1128
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
EL + VG + L+++ G + + E+E R ++ +L+ + T R + G
Sbjct: 1129 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185
Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
+ R A L + R Q+ P + +QA+ E + Q
Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1231
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
L + ++ + + C+R + + + + QL VA+ KK + + +
Sbjct: 1232 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1291
Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
V+ H +E T E LR ++EE + AE R++++E + +E +L +
Sbjct: 1292 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1350
Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
A E+E+ LQQR +E + +A ++A+QQ+ + +E
Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1407
Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
+ +AA +L E+ +R LE + E +L+ +A EE++AQ
Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1466
Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
+ +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA
Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
+R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A
Sbjct: 1527 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1582
Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA
Sbjct: 1583 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1626
Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
+E Q S + +E E+E RR AV + + +Q E +
Sbjct: 1627 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676
Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
+L G ++ +L L + Q + Q LE
Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)
Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
+RQAEA R++L + +E R + + LE +++ G++ E++++R
Sbjct: 1415 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1458
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
+ + R + + + A+ + + QALEE
Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
L R + L + + R + T ++ E +QS + E QL
Sbjct: 1519 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576
Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
VAVA A+R+ + E+ + R +E W + + E LR + + A+
Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1633
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
Q E + E++ EA E+++ R ++ + LE++RQ
Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693
Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
+ LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + +
Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1751
Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
+E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ +
Sbjct: 1752 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++
Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1860
Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ +
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
Query: 548 EL 549
EL
Sbjct: 1921 EL 1922
Score = 85.9 bits (211), Expect = 2e-16
Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
ELQ+ A A A R++ + E+L R + E L+ E A + R
Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2236
Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K QE +++Q EA QE+ARL+Q E L ++R L+ + Q
Sbjct: 2237 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2295
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL
Sbjct: 2296 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
E R +E +QR + A E TQ ++ LVQ+ E+
Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
+R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2473
Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
L + SL + R +QL++ + QQ++ + + M E
Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533
Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E
Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2592
Query: 564 --ANQLLST-TLP 573
A+Q+ +T TLP
Sbjct: 2593 VTASQVAATKTLP 2605
Score = 67.4 bits (163), Expect = 6e-11
Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)
Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
Q+QLA AA R++ L + LA + E + EAE E LR L E+
Sbjct: 1794 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
R + +E + + + E + L + +S +Q R+R +EEE AL
Sbjct: 1853 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
E A AG+ EL +R+ E+ ++ Q E + Q
Sbjct: 1910 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1955
Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L
Sbjct: 1956 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014
Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E
Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2073
Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R Q + + Q Q E A +L Q E A+ + Q AE +E AR
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2126
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q E+ + + A ++ H A Q L
Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
Score = 67.4 bits (163), Expect = 6e-11
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E + K L E + +A ++ + E++ K + V+ R
Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
+AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E +
Sbjct: 2304 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2356
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
E + L LR+ AE R EE DA R + +E + R L +E+ T Q
Sbjct: 2357 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
+ Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + +
Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534
Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
R+Q L+ Q ++ LA + + + ++ EE+ + E
Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594
Query: 526 AREQARVCELQSGNQQLEEQRVE 548
A + A L +G L+ E
Sbjct: 2595 ASQVAATKTLPNGRDALDGPAAE 2617
Score = 39.7 bits (91), Expect = 0.013
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)
Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
+E Q RLEA+ Q L + + R QL L T R EE+
Sbjct: 841 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900
Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
+ Q H L+ HYQA +SQ ERE Q ++ Q A +
Sbjct: 901 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 957
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+
Sbjct: 958 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1011
Query: 469 SSL 471
L
Sbjct: 1012 EGL 1014
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 104 bits (259), Expect = 4e-22
Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV
Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997
Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++
Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057
Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A
Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2115
Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
Q + + + AL+++ A E EK K +++AQ E
Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175
Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+
Sbjct: 2176 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2235
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA
Sbjct: 2236 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295
Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q
Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2353
Query: 557 LQA 559
L+A
Sbjct: 2354 LEA 2356
Score = 103 bits (256), Expect = 9e-22
Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1452
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
L+ L+ + AE + + QE RL + + E + E E
Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
+AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+
Sbjct: 1513 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566
Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
+R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R +
Sbjct: 1567 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1621
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
+ +AL+L + + + Q E+E + +R R +A+E ++RQ
Sbjct: 1622 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1676
Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+ KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A +
Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1735
Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
+ Q+LE + ++ ++ +L + + ST S Q E E
Sbjct: 1736 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1778
Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620
R + A L+ + ++++ R
Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQR 1803
Score = 87.4 bits (215), Expect = 5e-17
Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)
Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
GAE++L E Q +L A+ ++ A A AQ D
Sbjct: 1086 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1136
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
EL + VG + L+++ G + + E+E R ++ +L+ + T R + G
Sbjct: 1137 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193
Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
+ R A L + R Q+ P + +QA+ E + Q
Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1239
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
L + ++ + + C+R + + + + QL VA+ KK + + +
Sbjct: 1240 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1299
Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
V+ H +E T E LR ++EE + AE R++++E + +E +L +
Sbjct: 1300 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1358
Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
A E+E+ LQQR +E + +A ++A+QQ+ + +E
Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1415
Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
+ +AA +L E+ +R LE + E +L+ +A EE++AQ
Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1474
Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
+ +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA
Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
+R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A
Sbjct: 1535 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1590
Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA
Sbjct: 1591 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1634
Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
+E Q S + +E E+E RR AV + + +Q E +
Sbjct: 1635 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684
Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
+L G ++ +L L + Q + Q LE
Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)
Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
+RQAEA R++L + +E R + + LE +++ G++ E++++R
Sbjct: 1423 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1466
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
+ + R + + + A+ + + QALEE
Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
L R + L + + R + T ++ E +QS + E QL
Sbjct: 1527 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584
Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
VAVA A+R+ + E+ + R +E W + + E LR + + A+
Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1641
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
Q E + E++ EA E+++ R ++ + LE++RQ
Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701
Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
+ LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + +
Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1759
Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
+E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ +
Sbjct: 1760 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++
Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1868
Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ +
Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928
Query: 548 EL 549
EL
Sbjct: 1929 EL 1930
Score = 85.9 bits (211), Expect = 2e-16
Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
ELQ+ A A A R++ + E+L R + E L+ E A + R
Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2244
Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K QE +++Q EA QE+ARL+Q E L ++R L+ + Q
Sbjct: 2245 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2303
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL
Sbjct: 2304 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362
Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
E R +E +QR + A E TQ ++ LVQ+ E+
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
+R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2481
Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
L + SL + R +QL++ + QQ++ + + M E
Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541
Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E
Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2600
Query: 564 --ANQLLST-TLP 573
A+Q+ +T TLP
Sbjct: 2601 VTASQVAATKTLP 2613
Score = 67.4 bits (163), Expect = 6e-11
Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)
Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
Q+QLA AA R++ L + LA + E + EAE E LR L E+
Sbjct: 1802 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860
Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
R + +E + + + E + L + +S +Q R+R +EEE AL
Sbjct: 1861 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
E A AG+ EL +R+ E+ ++ Q E + Q
Sbjct: 1918 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1963
Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L
Sbjct: 1964 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022
Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E
Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2081
Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R Q + + Q Q E A +L Q E A+ + Q AE +E AR
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2134
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q E+ + + A ++ H A Q L
Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164
Score = 67.4 bits (163), Expect = 6e-11
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E + K L E + +A ++ + E++ K + V+ R
Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
+AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E +
Sbjct: 2312 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2364
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
E + L LR+ AE R EE DA R + +E + R L +E+ T Q
Sbjct: 2365 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422
Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
+ Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + +
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482
Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542
Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
R+Q L+ Q ++ LA + + + ++ EE+ + E
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602
Query: 526 AREQARVCELQSGNQQLEEQRVE 548
A + A L +G L+ E
Sbjct: 2603 ASQVAATKTLPNGRDALDGPAAE 2625
Score = 39.7 bits (91), Expect = 0.013
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)
Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
+E Q RLEA+ Q L + + R QL L T R EE+
Sbjct: 849 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 908
Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
+ Q H L+ HYQA +SQ ERE Q ++ Q A +
Sbjct: 909 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 965
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+
Sbjct: 966 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1019
Query: 469 SSL 471
L
Sbjct: 1020 EGL 1022
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 104 bits (259), Expect = 4e-22
Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256
R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV
Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038
Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311
R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++
Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098
Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A
Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2156
Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400
Q + + + AL+++ A E EK K +++AQ E
Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216
Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447
T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+
Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2276
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498
E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA
Sbjct: 2277 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336
Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556
++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q
Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2394
Query: 557 LQA 559
L+A
Sbjct: 2395 LEA 2397
Score = 103 bits (256), Expect = 9e-22
Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%)
Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248
A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R
Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1493
Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297
L+ L+ + AE + + QE RL + + E + E E
Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357
+AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+
Sbjct: 1554 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607
Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417
+R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R +
Sbjct: 1608 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1662
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
+ +AL+L + + + Q E+E + +R R +A+E ++RQ
Sbjct: 1663 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1717
Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+ KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A +
Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1776
Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595
+ Q+LE + ++ ++ +L + + ST S Q E E
Sbjct: 1777 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1819
Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620
R + A L+ + ++++ R
Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQR 1844
Score = 87.4 bits (215), Expect = 5e-17
Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%)
Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72
GAE++L E Q +L A+ ++ A A AQ D
Sbjct: 1127 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1177
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128
EL + VG + L+++ G + + E+E R ++ +L+ + T R + G
Sbjct: 1178 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234
Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185
+ R A L + R Q+ P + +QA+ E + Q
Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1280
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239
L + ++ + + C+R + + + + QL VA+ KK + + +
Sbjct: 1281 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1340
Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287
V+ H +E T E LR ++EE + AE R++++E + +E +L +
Sbjct: 1341 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1399
Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332
A E+E+ LQQR +E + +A ++A+QQ+ + +E
Sbjct: 1400 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1456
Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
+ +AA +L E+ +R LE + E +L+ +A EE++AQ
Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1515
Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441
+ +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA
Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
+R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A
Sbjct: 1576 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1631
Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561
Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA
Sbjct: 1632 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1675
Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621
+E Q S + +E E+E RR AV + + +Q E +
Sbjct: 1676 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725
Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655
+L G ++ +L L + Q + Q LE
Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760
Score = 86.3 bits (212), Expect = 1e-16
Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%)
Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104
+RQAEA R++L + +E R + + LE +++ G++ E++++R
Sbjct: 1464 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1507
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
+ + R + + + A+ + + QALEE
Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219
L R + L + + R + T ++ E +QS + E QL
Sbjct: 1568 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625
Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
VAVA A+R+ + E+ + R +E W + + E LR + + A+
Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1682
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315
Q E + E++ EA E+++ R ++ + LE++RQ
Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742
Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368
+ LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + +
Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1800
Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427
+E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ +
Sbjct: 1801 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++
Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1909
Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ +
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969
Query: 548 EL 549
EL
Sbjct: 1970 EL 1971
Score = 85.9 bits (211), Expect = 2e-16
Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272
ELQ+ A A A R++ + E+L R + E L+ E A + R
Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2285
Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K QE +++Q EA QE+ARL+Q E L ++R L+ + Q
Sbjct: 2286 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2344
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384
V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL
Sbjct: 2345 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403
Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412
E R +E +QR + A E TQ ++ LVQ+ E+
Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470
+R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2522
Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510
L + SL + R +QL++ + QQ++ + + M E
Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582
Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563
RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E
Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2641
Query: 564 --ANQLLST-TLP 573
A+Q+ +T TLP
Sbjct: 2642 VTASQVAATKTLP 2654
Score = 67.4 bits (163), Expect = 6e-11
Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%)
Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265
Q+QLA AA R++ L + LA + E + EAE E LR L E+
Sbjct: 1843 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901
Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317
R + +E + + + E + L + +S +Q R+R +EEE AL
Sbjct: 1902 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377
E A AG+ EL +R+ E+ ++ Q E + Q
Sbjct: 1959 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2004
Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429
EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L
Sbjct: 2005 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063
Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480
QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E
Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2122
Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R Q + + Q Q E A +L Q E A+ + Q AE +E AR
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2175
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q E+ + + A ++ H A Q L
Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205
Score = 67.4 bits (163), Expect = 6e-11
Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L E + K L E + +A ++ + E++ K + V+ R
Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
+AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E +
Sbjct: 2353 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2405
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365
E + L LR+ AE R EE DA R + +E + R L +E+ T Q
Sbjct: 2406 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463
Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423
+ Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + +
Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523
Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583
Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
R+Q L+ Q ++ LA + + + ++ EE+ + E
Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2643
Query: 526 AREQARVCELQSGNQQLEEQRVE 548
A + A L +G L+ E
Sbjct: 2644 ASQVAATKTLPNGRDALDGPAAE 2666
Score = 39.7 bits (91), Expect = 0.013
Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%)
Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359
+E Q RLEA+ Q L + + R QL L T R EE+
Sbjct: 890 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 949
Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409
+ Q H L+ HYQA +SQ ERE Q ++ Q A +
Sbjct: 950 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1006
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468
S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+
Sbjct: 1007 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1060
Query: 469 SSL 471
L
Sbjct: 1061 EGL 1063
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 89.4 bits (220), Expect = 1e-17
Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%)
Query: 27 LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82
L + + + QL A L +AE T A + L E G +E SR +
Sbjct: 910 LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 968
Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141
+KK +HI E+E+ L+ + +R + + A ++ EED D
Sbjct: 969 -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1019
Query: 142 ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
+ L R L +D S+QA EE + SL + D L E R+
Sbjct: 1020 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1078
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257
E+ + L ELQ+Q+ V ++ + + QL + + R E E R ++L
Sbjct: 1079 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1135
Query: 258 RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307
+ L+E A AE + E V R + + L E +EAL E E S QQ R
Sbjct: 1136 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1195
Query: 308 TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363
E+E L LE E + +QE +R G+L+E E + A E+ R
Sbjct: 1196 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1255
Query: 364 QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413
+ +L+ +LQ E+ + +LE + ++ Q A +A E +L Q+E+
Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1315
Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473
+ G L+ A + L E+S +A+ + L+ E +L R +A+ + LR+
Sbjct: 1316 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1375
Query: 474 A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523
A+ RE ++LQ Q Q+E A L + E R + AE
Sbjct: 1376 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1431
Query: 524 RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577
RLA + V L+ G ++L+++ +E +L + L+ + +QLL
Sbjct: 1432 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1482
Query: 578 PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623
A +E E+ E A++L L++ +EAR+EL
Sbjct: 1483 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1527
Score = 86.7 bits (213), Expect = 9e-17
Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%)
Query: 6 DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65
D SS L E ++ L +L A+L + E ARAQL L S
Sbjct: 1086 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1142
Query: 66 EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124
L ++L + +++D + E+E++RG+L+ T+ T+ R
Sbjct: 1143 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1195
Query: 125 GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178
+RE++ + T T ++ +Q+L QAL EL + R G
Sbjct: 1196 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1249
Query: 179 ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234
+ LR L S T R+ E+ + L+ ++ E+Q + A + +++
Sbjct: 1250 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1309
Query: 235 LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277
L V N E++ + + L H A EL TR+K +
Sbjct: 1310 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1369
Query: 278 VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323
L + L E A E RE ++A+ Q E E EE R+ EA
Sbjct: 1370 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1429
Query: 324 QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
QR E D G+ +EL+ LE++RQ + E + ++ Q L EE A
Sbjct: 1430 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1489
Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436
L +E+ + EA+ L+L ++ E + R+ R AL+ E+ +
Sbjct: 1490 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1548
Query: 437 -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486
++ +E +R ++ + A L +VTE L A+++ LR +L+ H + LQ
Sbjct: 1549 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1608
Query: 487 -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
+ + +++LA QL +VE ER++R VA +L E+ + +G Q +E
Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1666
Query: 545 QRVELVERLQAMLQAHWDEANQ 566
+ V+ + ++QA ++ W E +
Sbjct: 1667 EAVKQLRKMQAQMKELWREVEE 1688
Score = 84.0 bits (206), Expect = 6e-16
Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%)
Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241
GLR+ L+ E R+ R +Q+ Q ++ E Q++ A A+ A E+ + AR
Sbjct: 1372 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1424
Query: 242 VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286
E + AE+TE + R LQ+E A + +Q++ V+ LE+
Sbjct: 1425 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484
Query: 287 ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322
E EA RE+E+ L +Q RE LE + +AL LEA
Sbjct: 1485 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1544
Query: 323 ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360
E +R C + E+ Q++E + LE AL + ER
Sbjct: 1545 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1604
Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397
+ E + Q ++ A++ER++E+ QR Q
Sbjct: 1605 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1664
Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453
E QL +Q++++ L E++ R R+ + + + R E++ ++L+ ELA
Sbjct: 1665 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1724
Query: 454 -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508
Q +Q E + +L +AA L E ++QL+ GQ ++EL + + ++ +
Sbjct: 1725 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1781
Query: 509 EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553
+R + E L+ E++ + +SG QQLE Q EL RL
Sbjct: 1782 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826
Score = 72.0 bits (175), Expect = 2e-12
Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%)
Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
ER E + + ++ A L TR L++ +A EEL + +LR + + L
Sbjct: 1497 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1543
Query: 189 ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
+ D S H + C E+ L+ +V EL+ +L A A + + ++ L R
Sbjct: 1544 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1603
Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300
++G + ER R L ++ + AE+ R ++ R +++L+ A + L E E +
Sbjct: 1604 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1655
Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
Q +EE +++A+ + EE +R S++RE E LE E
Sbjct: 1656 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1713
Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417
LQEE A ++ Q + A E + A + E R+LEG
Sbjct: 1714 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1761
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
L E + Q L+ RY +L +Q+E TE A+ S +A S
Sbjct: 1762 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1811
Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522
R+ +Q+Q+L G+ +E A A+ K+ +A E + Q E E
Sbjct: 1812 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1856
Score = 69.3 bits (168), Expect = 2e-11
Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%)
Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
D QG RD E RR+ + ++ + E ++Q +AVAA +K + +E+L +A
Sbjct: 1604 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1660
Query: 242 VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294
+G + +A+ E+ R ++E + E S+ +E+ RL+ +E + R
Sbjct: 1661 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1716
Query: 295 EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352
QE R R +++R + + + +L+E+R R GQL E E E
Sbjct: 1717 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1776
Query: 353 AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400
+ L + R+ Q E E + A E + QLER+ ++ + +A A
Sbjct: 1777 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1836
Query: 401 TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460
+ +A ++S++ + E +L+ RER +S R +R++ E L V+ E+RV
Sbjct: 1837 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1890
Query: 461 ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520
++L E + L ++QL++ +E AS+ + + E + AE
Sbjct: 1891 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1941
Query: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579
+ + R L+ G + V V RL+ + A +EA + + P P P +
Sbjct: 1942 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 1997
Query: 580 PPAGP 584
PPA P
Sbjct: 1998 PPAHP 2002
Score = 55.8 bits (133), Expect = 2e-07
Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%)
Query: 253 RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312
R + L+ +QE Q + + Q V +LE+ + E L E E + R L
Sbjct: 882 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 941
Query: 313 RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369
+Q L L + + R + EE + +R Q + R ++ L A LE E A+Q+ QL
Sbjct: 942 KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 996
Query: 370 K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425
+ E EE LE + K +E + + + + +E L+ R +
Sbjct: 997 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1056
Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485
+A +M + E R +LE +L++R+ ++ QE + Q + ++L
Sbjct: 1057 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1106
Query: 486 QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545
+ G+ ++EL + LA+ + E R + + + E + LA Q + + + E+Q
Sbjct: 1107 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1165
Query: 546 RVELVERLQAM 556
R +L E L+A+
Sbjct: 1166 RRDLGEELEAL 1176
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 89.4 bits (220), Expect = 1e-17
Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%)
Query: 27 LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82
L + + + QL A L +AE T A + L E G +E SR +
Sbjct: 902 LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 960
Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141
+KK +HI E+E+ L+ + +R + + A ++ EED D
Sbjct: 961 -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1011
Query: 142 ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
+ L R L +D S+QA EE + SL + D L E R+
Sbjct: 1012 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1070
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257
E+ + L ELQ+Q+ V ++ + + QL + + R E E R ++L
Sbjct: 1071 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1127
Query: 258 RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307
+ L+E A AE + E V R + + L E +EAL E E S QQ R
Sbjct: 1128 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1187
Query: 308 TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363
E+E L LE E + +QE +R G+L+E E + A E+ R
Sbjct: 1188 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1247
Query: 364 QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413
+ +L+ +LQ E+ + +LE + ++ Q A +A E +L Q+E+
Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1307
Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473
+ G L+ A + L E+S +A+ + L+ E +L R +A+ + LR+
Sbjct: 1308 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1367
Query: 474 A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523
A+ RE ++LQ Q Q+E A L + E R + AE
Sbjct: 1368 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1423
Query: 524 RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577
RLA + V L+ G ++L+++ +E +L + L+ + +QLL
Sbjct: 1424 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1474
Query: 578 PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623
A +E E+ E A++L L++ +EAR+EL
Sbjct: 1475 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1519
Score = 86.7 bits (213), Expect = 9e-17
Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%)
Query: 6 DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65
D SS L E ++ L +L A+L + E ARAQL L S
Sbjct: 1078 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1134
Query: 66 EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124
L ++L + +++D + E+E++RG+L+ T+ T+ R
Sbjct: 1135 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1187
Query: 125 GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178
+RE++ + T T ++ +Q+L QAL EL + R G
Sbjct: 1188 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1241
Query: 179 ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234
+ LR L S T R+ E+ + L+ ++ E+Q + A + +++
Sbjct: 1242 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1301
Query: 235 LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277
L V N E++ + + L H A EL TR+K +
Sbjct: 1302 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1361
Query: 278 VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323
L + L E A E RE ++A+ Q E E EE R+ EA
Sbjct: 1362 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1421
Query: 324 QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
QR E D G+ +EL+ LE++RQ + E + ++ Q L EE A
Sbjct: 1422 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1481
Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436
L +E+ + EA+ L+L ++ E + R+ R AL+ E+ +
Sbjct: 1482 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1540
Query: 437 -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486
++ +E +R ++ + A L +VTE L A+++ LR +L+ H + LQ
Sbjct: 1541 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1600
Query: 487 -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
+ + +++LA QL +VE ER++R VA +L E+ + +G Q +E
Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1658
Query: 545 QRVELVERLQAMLQAHWDEANQ 566
+ V+ + ++QA ++ W E +
Sbjct: 1659 EAVKQLRKMQAQMKELWREVEE 1680
Score = 84.0 bits (206), Expect = 6e-16
Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%)
Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241
GLR+ L+ E R+ R +Q+ Q ++ E Q++ A A+ A E+ + AR
Sbjct: 1364 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1416
Query: 242 VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286
E + AE+TE + R LQ+E A + +Q++ V+ LE+
Sbjct: 1417 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476
Query: 287 ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322
E EA RE+E+ L +Q RE LE + +AL LEA
Sbjct: 1477 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1536
Query: 323 ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360
E +R C + E+ Q++E + LE AL + ER
Sbjct: 1537 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1596
Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397
+ E + Q ++ A++ER++E+ QR Q
Sbjct: 1597 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1656
Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453
E QL +Q++++ L E++ R R+ + + + R E++ ++L+ ELA
Sbjct: 1657 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1716
Query: 454 -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508
Q +Q E + +L +AA L E ++QL+ GQ ++EL + + ++ +
Sbjct: 1717 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1773
Query: 509 EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553
+R + E L+ E++ + +SG QQLE Q EL RL
Sbjct: 1774 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818
Score = 72.0 bits (175), Expect = 2e-12
Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%)
Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
ER E + + ++ A L TR L++ +A EEL + +LR + + L
Sbjct: 1489 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1535
Query: 189 ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
+ D S H + C E+ L+ +V EL+ +L A A + + ++ L R
Sbjct: 1536 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1595
Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300
++G + ER R L ++ + AE+ R ++ R +++L+ A + L E E +
Sbjct: 1596 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1647
Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
Q +EE +++A+ + EE +R S++RE E LE E
Sbjct: 1648 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1705
Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417
LQEE A ++ Q + A E + A + E R+LEG
Sbjct: 1706 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1753
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
L E + Q L+ RY +L +Q+E TE A+ S +A S
Sbjct: 1754 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1803
Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522
R+ +Q+Q+L G+ +E A A+ K+ +A E + Q E E
Sbjct: 1804 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1848
Score = 69.3 bits (168), Expect = 2e-11
Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%)
Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
D QG RD E RR+ + ++ + E ++Q +AVAA +K + +E+L +A
Sbjct: 1596 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1652
Query: 242 VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294
+G + +A+ E+ R ++E + E S+ +E+ RL+ +E + R
Sbjct: 1653 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1708
Query: 295 EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352
QE R R +++R + + + +L+E+R R GQL E E E
Sbjct: 1709 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1768
Query: 353 AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400
+ L + R+ Q E E + A E + QLER+ ++ + +A A
Sbjct: 1769 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1828
Query: 401 TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460
+ +A ++S++ + E +L+ RER +S R +R++ E L V+ E+RV
Sbjct: 1829 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1882
Query: 461 ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520
++L E + L ++QL++ +E AS+ + + E + AE
Sbjct: 1883 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1933
Query: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579
+ + R L+ G + V V RL+ + A +EA + + P P P +
Sbjct: 1934 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 1989
Query: 580 PPAGP 584
PPA P
Sbjct: 1990 PPAHP 1994
Score = 55.8 bits (133), Expect = 2e-07
Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%)
Query: 253 RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312
R + L+ +QE Q + + Q V +LE+ + E L E E + R L
Sbjct: 874 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 933
Query: 313 RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369
+Q L L + + R + EE + +R Q + R ++ L A LE E A+Q+ QL
Sbjct: 934 KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 988
Query: 370 K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425
+ E EE LE + K +E + + + + +E L+ R +
Sbjct: 989 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1048
Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485
+A +M + E R +LE +L++R+ ++ QE + Q + ++L
Sbjct: 1049 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1098
Query: 486 QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545
+ G+ ++EL + LA+ + E R + + + E + LA Q + + + E+Q
Sbjct: 1099 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1157
Query: 546 RVELVERLQAM 556
R +L E L+A+
Sbjct: 1158 RRDLGEELEAL 1168
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 89.4 bits (220), Expect = 1e-17
Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%)
Query: 27 LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82
L + + + QL A L +AE T A + L E G +E SR +
Sbjct: 943 LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 1001
Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141
+KK +HI E+E+ L+ + +R + + A ++ EED D
Sbjct: 1002 -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1052
Query: 142 ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
+ L R L +D S+QA EE + SL + D L E R+
Sbjct: 1053 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1111
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257
E+ + L ELQ+Q+ V ++ + + QL + + R E E R ++L
Sbjct: 1112 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1168
Query: 258 RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307
+ L+E A AE + E V R + + L E +EAL E E S QQ R
Sbjct: 1169 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1228
Query: 308 TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363
E+E L LE E + +QE +R G+L+E E + A E+ R
Sbjct: 1229 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1288
Query: 364 QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413
+ +L+ +LQ E+ + +LE + ++ Q A +A E +L Q+E+
Sbjct: 1289 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1348
Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473
+ G L+ A + L E+S +A+ + L+ E +L R +A+ + LR+
Sbjct: 1349 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1408
Query: 474 A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523
A+ RE ++LQ Q Q+E A L + E R + AE
Sbjct: 1409 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1464
Query: 524 RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577
RLA + V L+ G ++L+++ +E +L + L+ + +QLL
Sbjct: 1465 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1515
Query: 578 PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623
A +E E+ E A++L L++ +EAR+EL
Sbjct: 1516 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1560
Score = 86.7 bits (213), Expect = 9e-17
Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%)
Query: 6 DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65
D SS L E ++ L +L A+L + E ARAQL L S
Sbjct: 1119 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1175
Query: 66 EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124
L ++L + +++D + E+E++RG+L+ T+ T+ R
Sbjct: 1176 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1228
Query: 125 GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178
+RE++ + T T ++ +Q+L QAL EL + R G
Sbjct: 1229 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1282
Query: 179 ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234
+ LR L S T R+ E+ + L+ ++ E+Q + A + +++
Sbjct: 1283 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1342
Query: 235 LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277
L V N E++ + + L H A EL TR+K +
Sbjct: 1343 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1402
Query: 278 VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323
L + L E A E RE ++A+ Q E E EE R+ EA
Sbjct: 1403 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1462
Query: 324 QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383
QR E D G+ +EL+ LE++RQ + E + ++ Q L EE A
Sbjct: 1463 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1522
Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436
L +E+ + EA+ L+L ++ E + R+ R AL+ E+ +
Sbjct: 1523 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1581
Query: 437 -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486
++ +E +R ++ + A L +VTE L A+++ LR +L+ H + LQ
Sbjct: 1582 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1641
Query: 487 -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
+ + +++LA QL +VE ER++R VA +L E+ + +G Q +E
Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1699
Query: 545 QRVELVERLQAMLQAHWDEANQ 566
+ V+ + ++QA ++ W E +
Sbjct: 1700 EAVKQLRKMQAQMKELWREVEE 1721
Score = 84.0 bits (206), Expect = 6e-16
Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%)
Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241
GLR+ L+ E R+ R +Q+ Q ++ E Q++ A A+ A E+ + AR
Sbjct: 1405 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1457
Query: 242 VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286
E + AE+TE + R LQ+E A + +Q++ V+ LE+
Sbjct: 1458 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1517
Query: 287 ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322
E EA RE+E+ L +Q RE LE + +AL LEA
Sbjct: 1518 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1577
Query: 323 ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360
E +R C + E+ Q++E + LE AL + ER
Sbjct: 1578 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1637
Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397
+ E + Q ++ A++ER++E+ QR Q
Sbjct: 1638 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1697
Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453
E QL +Q++++ L E++ R R+ + + + R E++ ++L+ ELA
Sbjct: 1698 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1757
Query: 454 -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508
Q +Q E + +L +AA L E ++QL+ GQ ++EL + + ++ +
Sbjct: 1758 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1814
Query: 509 EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553
+R + E L+ E++ + +SG QQLE Q EL RL
Sbjct: 1815 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859
Score = 72.0 bits (175), Expect = 2e-12
Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%)
Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188
ER E + + ++ A L TR L++ +A EEL + +LR + + L
Sbjct: 1530 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1576
Query: 189 ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
+ D S H + C E+ L+ +V EL+ +L A A + + ++ L R
Sbjct: 1577 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1636
Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300
++G + ER R L ++ + AE+ R ++ R +++L+ A + L E E +
Sbjct: 1637 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1688
Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360
Q +EE +++A+ + EE +R S++RE E LE E
Sbjct: 1689 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1746
Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417
LQEE A ++ Q + A E + A + E R+LEG
Sbjct: 1747 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1794
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
L E + Q L+ RY +L +Q+E TE A+ S +A S
Sbjct: 1795 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1844
Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522
R+ +Q+Q+L G+ +E A A+ K+ +A E + Q E E
Sbjct: 1845 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1889
Score = 69.3 bits (168), Expect = 2e-11
Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%)
Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
D QG RD E RR+ + ++ + E ++Q +AVAA +K + +E+L +A
Sbjct: 1637 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1693
Query: 242 VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294
+G + +A+ E+ R ++E + E S+ +E+ RL+ +E + R
Sbjct: 1694 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1749
Query: 295 EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352
QE R R +++R + + + +L+E+R R GQL E E E
Sbjct: 1750 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1809
Query: 353 AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400
+ L + R+ Q E E + A E + QLER+ ++ + +A A
Sbjct: 1810 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1869
Query: 401 TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460
+ +A ++S++ + E +L+ RER +S R +R++ E L V+ E+RV
Sbjct: 1870 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1923
Query: 461 ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520
++L E + L ++QL++ +E AS+ + + E + AE
Sbjct: 1924 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1974
Query: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579
+ + R L+ G + V V RL+ + A +EA + + P P P +
Sbjct: 1975 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 2030
Query: 580 PPAGP 584
PPA P
Sbjct: 2031 PPAHP 2035
Score = 55.8 bits (133), Expect = 2e-07
Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%)
Query: 253 RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312
R + L+ +QE Q + + Q V +LE+ + E L E E + R L
Sbjct: 915 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 974
Query: 313 RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369
+Q L L + + R + EE + +R Q + R ++ L A LE E A+Q+ QL
Sbjct: 975 KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 1029
Query: 370 K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425
+ E EE LE + K +E + + + + +E L+ R +
Sbjct: 1030 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1089
Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485
+A +M + E R +LE +L++R+ ++ QE + Q + ++L
Sbjct: 1090 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1139
Query: 486 QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545
+ G+ ++EL + LA+ + E R + + + E + LA Q + + + E+Q
Sbjct: 1140 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1198
Query: 546 RVELVERLQAM 556
R +L E L+A+
Sbjct: 1199 RRDLGEELEAL 1209
>gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens]
Length = 1080
Score = 88.2 bits (217), Expect = 3e-17
Identities = 134/562 (23%), Positives = 228/562 (40%), Gaps = 72/562 (12%)
Query: 25 PGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGF-AQELSRSLSVGL 83
PG ++ SEV++ + +RL + E +A L L L +E ++LS L
Sbjct: 557 PGPLELGSEVSTSV---MRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQL 613
Query: 84 EKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTAT 143
++ + + + ++ L + Q D +E ++ED ++ A
Sbjct: 614 QRQREHYEAT--------IQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQ 665
Query: 144 L-----LNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRK 198
L + L++L ++ E+ T + +GL + R K
Sbjct: 666 AQAQHELEIKKLKELMSATEKARREKWISEKTK-----KIKEVTVRGLEPEIQKLIARHK 720
Query: 199 HCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR 258
R ++SL L LQ + R+ + + EQL++ + G E R +
Sbjct: 721 QEVRRLKSLHEAEL-LQSDERASQRCLRQAEELREQLEREKEAL--GQQERERARQRFQQ 777
Query: 259 GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRE-RETLEEERQALT 317
L++E A + R RL ++E E L ++ R + E R+ LEE ALT
Sbjct: 778 HLEQEQWALQQQRQ-------RLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALT 830
Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA-----QQEHQLKEH 372
L AE ++ QE R EL TL+ LE ERQ W ++E L
Sbjct: 831 RALRAEFEKGREEQERR---------HQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881
Query: 373 YQALQEESQAQLEREKEK--SQREAQAAWETQHQLALVQSEVRRL----EGELDTARRER 426
Q L+EE + ++E E + EA A + +S ++RL E EL +
Sbjct: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSE 941
Query: 427 DALQ-----LEMSLVQARYESQRIQ---LESELAVQLEQRVTERLAQAQESSLRQAASLR 478
LQ L+ L +A E+ R+Q + E A++ Q V E+L+ ++ S+L Q
Sbjct: 942 RKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS-SERSNLAQVI--- 997
Query: 479 EHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R++ +D ++E Q K E+A + RQQ E+ R+ AR E S
Sbjct: 998 ---RQEFEDRLAASEEETR----QAKAELATLQARQQLELEEVHRRVKTALARKEEAVSS 1050
Query: 539 NQQLEEQRVELVERLQAMLQAH 560
+ E V+ + L+ +L+ H
Sbjct: 1051 LRTQHEAAVKRADHLEELLEQH 1072
Score = 72.0 bits (175), Expect = 2e-12
Identities = 89/332 (26%), Positives = 152/332 (45%), Gaps = 46/332 (13%)
Query: 269 LTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET---LEEERQALTLRLEAEQQ 325
L+ +K Q ++ L++ + L+ +QE + E + L+LE E++
Sbjct: 521 LSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEK 580
Query: 326 RCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEH-------------QLKEH 372
+ +L +R A+ L+ R ET +A RQ Q+EH QL E
Sbjct: 581 KQAMLLLQRALAQQRDLTARRVKETEKAL---SRQLQRQREHYEATIQRHLAFIDQLIED 637
Query: 373 YQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER------ 426
+ L E+ +A + K++ QR + + Q Q L +++ L + ARRE+
Sbjct: 638 KKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKT 697
Query: 427 --------DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR 478
L+ E+ + AR++ + +L+S +L Q ER A + LRQA LR
Sbjct: 698 KKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQS-DER---ASQRCLRQAEELR 753
Query: 479 EHHRKQLQDLSGQHQQELASQLAQFKVEMAE---REERQQ---QVAEDYELRLAREQARV 532
E ++ + L GQ ++E A Q Q +E + +++RQ+ +VAE+ E RL ++ AR
Sbjct: 754 EQLEREKEAL-GQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERE-RLGQQAARQ 811
Query: 533 -CELQSGNQQLEEQRVELVERLQAMLQAHWDE 563
EL+ QQLEE L L+A + +E
Sbjct: 812 RAELEELRQQLEESSSALTRALRAEFEKGREE 843
Score = 33.1 bits (74), Expect = 1.2
Identities = 93/403 (23%), Positives = 146/403 (36%), Gaps = 96/403 (23%)
Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQ 443
L R KE ++ EA+ +Q + R + + RR A +LE L+QA+ E Q
Sbjct: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQ----RRGAGAARLE-HLLQAKREEQ 304
Query: 444 RIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQF 503
R + + L Q+ +A+E RQA R +Q+L Q ++ L +Q
Sbjct: 305 RQRSGEGTLLDLHQQKEAARRKAREEKARQA------RRAAIQEL--QQKRALRAQ---- 352
Query: 504 KVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDE 563
K AER + + RV ++ Q+L + L+A+
Sbjct: 353 KASTAERGPPENP-----------RETRVPGMRQPAQELSPTPGGTAHQA---LKAN--- 395
Query: 564 ANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623
N P P SSP PQ+P ++ + VL Q A D L
Sbjct: 396 -NTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDR------------TQDVLAQD-AAGDNL 441
Query: 624 PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPD------------------------ 659
P S+ S GP + H+ Q LE +PD
Sbjct: 442 EMMAPSRGSAKS-----RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASS 496
Query: 660 LTSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLET 719
LT+ F L AF P P +G L L A+L+ + +FL ++ ++
Sbjct: 497 LTADNLEKFGKLSAF--------------PEPPEDGTL---LSEAKLQSIMSFLDEMEKS 539
Query: 720 VPQNNENPSVDLLPPKS-GPLTVPSWEEAPQVPRIPPPVHKTK 761
++ +P GPL + S E + V R+ V + K
Sbjct: 540 GQDQLDSQQEGWVPEAGPGPLELGS-EVSTSVMRLKLEVEEKK 581
>gi|16262452 cingulin [Homo sapiens]
Length = 1203
Score = 87.4 bits (215), Expect = 5e-17
Identities = 119/442 (26%), Positives = 195/442 (44%), Gaps = 82/442 (18%)
Query: 193 EHTRRKHCERHIQSL--QTRVLELQQQLAVA-VAADRKKDTMIE--QLDKTLARVVEGWN 247
E + ER Q + + R EL++QLAV V ADR ++ + QL KTL ++ + +
Sbjct: 639 EELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ--D 696
Query: 248 RHEAERTEVLRG-----LQEEHQAAELTRSKQQET-------VTRLEQSLSE-------- 287
EA + +++ L + A E T + QE + LEQ L E
Sbjct: 697 CEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGG 756
Query: 288 -AMEALNRE------------QESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEER 334
A+EA R+ +E+ Q E +L ++AL RLE Q+ L +E+
Sbjct: 757 EAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ 816
Query: 335 DAARAGQLSEHRELETLR---AALEEERQTWAQQEHQLKEHYQALQEES-------QAQL 384
E ++ E LR A LEE+++ + +L + + + E+S QAQL
Sbjct: 817 QTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQL 876
Query: 385 EREKEKSQRE-----------AQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEM 433
E KEK++RE A A +T L+ +Q E++RL L ++ ERD +L+
Sbjct: 877 EDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDK 936
Query: 434 SLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQ 493
L+ R Q ++ E+E + + +L +E R L E K +L
Sbjct: 937 ELLAQRL--QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDE--EKNTVELLTDRV 992
Query: 494 QELASQLAQFKVE-MAEREERQ---------QQVAEDYELRLA------REQARVCELQS 537
Q+ Q + E M ER RQ ++ +D + RLA + A + +L+S
Sbjct: 993 NRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLES 1052
Query: 538 GNQQLEEQRVELVERLQAMLQA 559
NQ L+E R++ ER + +LQ+
Sbjct: 1053 QNQLLQE-RLQAEEREKTVLQS 1073
Score = 73.6 bits (179), Expect = 8e-13
Identities = 112/430 (26%), Positives = 186/430 (43%), Gaps = 69/430 (16%)
Query: 207 LQTRVLELQQQLAVAVAADRKKDTMIEQLDKT---LARVVEGWNR-------HEAERTEV 256
L+T+V+ELQ +L + K+ +++ L +T L V+EG R E E T +
Sbjct: 441 LETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTAL 500
Query: 257 LRGLQEE----HQAAELTRSKQQETVTRLEQSLSEAME-----ALNREQESARLQ--QRE 305
L+EE Q E R + Q +L +S+ +A + R++ SA ++ QRE
Sbjct: 501 KGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRE 560
Query: 306 RETLEEER-------QALTLRLEAEQQRCCVLQEERDAARAGQLSE-----HRELETLRA 353
E EE Q L A +Q L+ E++ +L E RELE RA
Sbjct: 561 LEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEE-ELGEKIEVLQRELEQARA 619
Query: 354 ALEEERQTWAQQEHQLK--EHYQALQEESQAQ------LEREKEKS----QREAQAAWET 401
+ + RQ ++ L+ E + LQ E Q+Q +RE EK + EA E
Sbjct: 620 SAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGREL 679
Query: 402 QHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLES---------ELA 452
+ Q +Q +++L + + A + + + E +++ R + L
Sbjct: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739
Query: 453 VQLEQRVTERL-----AQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507
+ LEQ++ E +A E+ LR E ++QL++ Q+E S A +
Sbjct: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799
Query: 508 AEREERQQQVA----EDYEL-RLAREQARVCE-LQSGNQQLEEQRVEL---VERLQAMLQ 558
A EE Q+ +A E L R E+ + E L+ G +LEEQ+ L V+RL L+
Sbjct: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859
Query: 559 AHWDEANQLL 568
+++ Q L
Sbjct: 860 KIGEDSKQAL 869
Score = 61.2 bits (147), Expect = 4e-09
Identities = 82/321 (25%), Positives = 149/321 (46%), Gaps = 47/321 (14%)
Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164
QLQ L+ ++ A R+ A ++R+ +D + S++ T LQD QAL+
Sbjct: 871 QLQAQLEDYKEKARREV----ADAQRQAKD-WASEAEKTSGGLSRLQD-EIQRLRQALQA 924
Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAA 224
+ R L QGL +++ + R ++ L+ +V L+ +L
Sbjct: 925 SQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL------ 978
Query: 225 DRKKDTMIEQLDKTLARVVEGWNRHEAERTEVL--RGLQEEHQAAELTRSKQQETV-TRL 281
D +K+T+ D RV G ++ + RTE++ R +++ + +++ +Q + + TRL
Sbjct: 979 DEEKNTVELLTD----RVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRL 1034
Query: 282 EQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQ 341
S ++ SA L Q LE + Q L RL+AE++ VLQ
Sbjct: 1035 ASSEGF-------QKPSASLSQ-----LESQNQLLQERLQAEEREKTVLQSTNRKLE--- 1079
Query: 342 LSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ---EESQAQLER---EKEKSQREA 395
R+++ L +E+ERQ Q+ QL +AL+ +E++ ++ER ++K+QRE
Sbjct: 1080 ----RKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135
Query: 396 QAAWETQHQLALVQSEVRRLE 416
+ E QL Q+ ++ LE
Sbjct: 1136 EEQHEVNEQL---QARIKSLE 1153
Score = 54.7 bits (130), Expect = 4e-07
Identities = 90/452 (19%), Positives = 173/452 (38%), Gaps = 55/452 (12%)
Query: 211 VLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270
+L QQ+ A + D K T+ L EG + E + + E+ Q +
Sbjct: 298 LLRDQQEAAPPGSVDHMKATIYGILR-------EGSSESETSVRRKVSLVLEKMQPLVMV 350
Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVL 330
S + V + L+ +E L R+ + + ++R+ LE + L +LE + + C L
Sbjct: 351 SSGSTKAVAG-QGELTRKVEELQRKLDE---EVKKRQKLEPSQVGLERQLEEKTEECSRL 406
Query: 331 QEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKE------HYQALQEESQAQL 384
QE + + ++EL+ ++ L++ E Q+ E H Q + + L
Sbjct: 407 QELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLL 466
Query: 385 E---REKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE 441
+ +E + + + QL L + E+ L+G L RD E+ V+ +Y+
Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQ---EVEHVRQQYQ 523
Query: 442 SQRIQL--------ESELAVQLEQRVTERLAQAQESSLRQAASLREH----HRKQLQDLS 489
QL + ++ E++ L + + L + + H +K +DL
Sbjct: 524 RDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLR 583
Query: 490 GQHQ---------QELASQLAQFKVEMAEREERQQQVA-------EDYELRLAREQARVC 533
Q +E+ +L + K+E+ +RE Q + + E + L R Q +
Sbjct: 584 ATKQELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK 642
Query: 534 ELQSGNQQLE---EQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQ 590
ELQ+ Q E R +E+ A+L+ D +L L +
Sbjct: 643 ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK 702
Query: 591 EPEKEERRVWTMPPMAVALKPVLQQSREARDE 622
E + A++ L++++E DE
Sbjct: 703 AKMVAEAEATVLGQRRAAVETTLRETQEENDE 734
Score = 52.4 bits (124), Expect = 2e-06
Identities = 77/349 (22%), Positives = 146/349 (41%), Gaps = 20/349 (5%)
Query: 104 GQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALE 163
GQ Q L + + + + G EE D T LN + L+ + S QAL+
Sbjct: 813 GQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN-KELEKIGEDSK-QALQ 870
Query: 164 ELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVA 223
+L + + D Q R A D K + LQ + L+Q L + A
Sbjct: 871 QLQAQLEDYKEKARREVADAQ--RQAKDWASEAEK-TSGGLSRLQDEIQRLRQALQASQA 927
Query: 224 ----ADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVT 279
A K+ + ++L + L + E R + +R L+GL+E+ E +++ TV
Sbjct: 928 ERDTARLDKELLAQRL-QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE 986
Query: 280 RLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-ERDAAR 338
L ++ + +++ + ++ R+ LE ++ +L + + + R + ++ +A
Sbjct: 987 LLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSAS 1046
Query: 339 AGQLSEHRELETLRAALEEERQTWAQQ-----EHQLKEHYQALQEESQAQLEREKEKSQR 393
QL +L R EE +T Q E ++KE +++E Q +++ + S R
Sbjct: 1047 LSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLR 1106
Query: 394 EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYES 442
+ Q+ + E+ RL+G A+RE + +QAR +S
Sbjct: 1107 VKAL----KRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151
Score = 51.6 bits (122), Expect = 3e-06
Identities = 99/478 (20%), Positives = 188/478 (39%), Gaps = 75/478 (15%)
Query: 81 VGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDS 140
+GLE+ LK+ G + E+V +L+ LQ R A + L + + EE S
Sbjct: 740 LGLEQQLKETRGL--VDGGEAVEARLRDKLQ--RLEAEKQQLEEALNASQEEEGSL---- 791
Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
A A L R + G + Q L AL+ E +R
Sbjct: 792 ------------------AAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR--- 830
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260
+ L+ EL++Q + DR D + ++L+K + + +A+ +
Sbjct: 831 ----EVLRRGKAELEEQKRLL---DRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKA 883
Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320
+ E A+ + LS + + R +++ + Q ER+T +++ L RL
Sbjct: 884 RREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRL 943
Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALEEERQT----------WAQQEHQL 369
+ +Q + +D RA QL E + L L+EE+ T Q QL
Sbjct: 944 QGLEQEAENKKRSQDD-RARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQL 1002
Query: 370 KEHYQALQEESQAQ-LEREKEKSQRE----------AQAAWETQHQLALVQSEVRRLEGE 418
+ + +QE S Q LE +K +R+ ++ + L+ ++S+ + L+
Sbjct: 1003 RT--ELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQER 1060
Query: 419 LDTARRERDALQLEMSLVQARYESQRIQLESEL--------AVQLEQRVTERLAQAQESS 470
L RE+ LQ ++ + + IQ+E E + L + +R E
Sbjct: 1061 LQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEE 1120
Query: 471 LRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528
+ + LR+ ++++++ Q E+ QL Q +++ E++ ++ E L E
Sbjct: 1121 IERLDGLRKKAQREVEE-----QHEVNEQL-QARIKSLEKDSWRKASRSAAESALKNE 1172
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 87.0 bits (214), Expect = 7e-17
Identities = 92/407 (22%), Positives = 185/407 (45%), Gaps = 37/407 (9%)
Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
RDAL E R + + L+ + ELQ++L + + + ++ L + L
Sbjct: 199 RDALSLELYRNTITD---EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL------- 248
Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSL--SEAMEALNREQESARLQQR 304
ER ++L Q+ A+ + Q +L+ + +E LN++QE +Q
Sbjct: 249 -----ERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE 303
Query: 305 ERETLEEER---QALTLRLEAE----QQRCCVLQEERDAARAGQL--SEHRELETLRAAL 355
E+ +EE+ Q L +R + E Q+ QEE+ + ++ E + E
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363
Query: 356 EEERQTWAQQE--HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVR 413
E+E + W Q+E + E Q +EE Q E+ +E+ ++ + W + ++ ++R
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR 423
Query: 414 RLEGELDTARRERDALQLEMSL----VQARYESQRIQLESELAVQLE---QRVTERLAQA 466
E E+ R+E +LE + + R +++Q E E + E QR E++ +
Sbjct: 424 EQEEEM--WRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQ 481
Query: 467 QESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLA 526
+E + RQ L++ + Q+ Q+E + + E E+ +RQ++ + E+RL
Sbjct: 482 EEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLW 541
Query: 527 REQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLP 573
+++ ++ E + Q+LEE+ +L ++ + + A + +Q L T P
Sbjct: 542 QQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP 588
Score = 54.7 bits (130), Expect = 4e-07
Identities = 56/267 (20%), Positives = 123/267 (46%), Gaps = 21/267 (7%)
Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
+ER+ L E T+ E +++ LQE+ + + ++ L+ LE +
Sbjct: 197 KERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLP 256
Query: 364 QQEHQ-----LKEHYQALQEESQAQLEREK---EKSQREAQAAWETQHQLALVQSEVRRL 415
QQ+ Q L + Q++ + QAQ+E + +Q++ + W + ++ + E +
Sbjct: 257 QQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ--EQEEKMC 314
Query: 416 EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRV---TERLAQAQESSLR 472
E EL +E + E + + + ++I+ + + + E+++ E++ + +E R
Sbjct: 315 EQELKIREQEEKMWRQEEKMHE---QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWR 371
Query: 473 QAASLREHHRK-QLQDLSGQHQQELASQLAQFKVEMAEREER----QQQVAEDYELRLAR 527
Q +RE K Q Q+ Q+E + + + E R+E+ Q + + E + R
Sbjct: 372 QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431
Query: 528 EQARVCELQSGNQQLEEQRVELVERLQ 554
++ ++ EL+ Q EE+ E+ E++Q
Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQ 458
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 87.0 bits (214), Expect = 7e-17
Identities = 107/398 (26%), Positives = 182/398 (45%), Gaps = 50/398 (12%)
Query: 184 QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243
QGL +L ++ E+ + +L+ +LQ+QLA ++ +EQ + R V
Sbjct: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861
Query: 244 EGWNRHEAERTEVLR---GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEA--LNREQES 298
E R E+ + + GL + AAE E TRL EA+E +++
Sbjct: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE-KEALEGSLFEVQRQL 920
Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358
A+L+ R RE LE E QAL L E L+++ A + +A+L++E
Sbjct: 921 AQLEAR-REQLEAEGQALLLAKETLTGELAGLRQQIIATQE------------KASLDKE 967
Query: 359 RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAW-ETQHQLALVQSEVRRLEG 417
AQ+ Q + QA E +A E + ++ QRE +AAW E + + A +QS+++R +
Sbjct: 968 --LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQE 1025
Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
EL AR E+++ +L E+A L+Q E L A ES +QA SL
Sbjct: 1026 EL-----------------LARLEAEKEELSEEIAA-LQQERDEGLLLA-ESEKQQALSL 1066
Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQ--------VAEDYELRLAREQ 529
+E + L + + LA+ + + + + + RQ+Q +E +LR RE+
Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126
Query: 530 ARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567
A Q ++L+EQ +L ++ + L+ + QL
Sbjct: 1127 AAAAHAQE-VRRLQEQARDLGKQRDSCLREAEELRTQL 1163
Score = 78.2 bits (191), Expect = 3e-14
Identities = 105/342 (30%), Positives = 153/342 (44%), Gaps = 48/342 (14%)
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260
E Q+LQ RV LQ+Q+A + +E+L+ LA+V E E + +RGL
Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES----EGALRDKVRGL 1731
Query: 261 QEE--HQAAEL--TRSKQ---QETVTRLE---QSLSEAMEALNREQESARLQQ----RER 306
E +A L TR K Q+ +T E Q L E ++A + AR Q +
Sbjct: 1732 TEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQV 1791
Query: 307 ETLEEERQALTL-RLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER------ 359
+TL E L L R+EAE Q LQ+ R+ R Q E L T++ +E R
Sbjct: 1792 QTLRGEVADLELQRVEAEGQ----LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERL 1847
Query: 360 ----QTWAQQEHQLKE-HYQALQ-EESQAQLEREKEKSQREAQAAWETQHQLALVQSEV- 412
+ AQ E + +E AL+ E+ + L R +K +RE + E +L+ + +
Sbjct: 1848 GSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLD 1907
Query: 413 RRLEG-ELDTARRERDALQLEMSLVQARYESQRIQLE---SELAVQLEQRVTERLAQAQE 468
R L G EL+ A +R QLE +V QLE + ++L+Q V ERL AQ
Sbjct: 1908 RTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV-ERLRSAQA 1966
Query: 469 SSLRQAASLREHHR-------KQLQDLSGQHQQELASQLAQF 503
+ R + HR +Q+ L GQ QQEL A F
Sbjct: 1967 QTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008
Score = 77.4 bits (189), Expect = 6e-14
Identities = 133/548 (24%), Positives = 228/548 (41%), Gaps = 92/548 (16%)
Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDS----FDS 138
LEK+ KD ++ + +ES+R Q Q L+T + L A + + +S S
Sbjct: 414 LEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGS 473
Query: 139 DSTATLLNTRPLQDLSPSSSAQALEELFP-RYTSLRPGP--------------------P 177
+ TA N L+ LS + P R S R GP
Sbjct: 474 ERTADASN-GSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQ 532
Query: 178 LNPPDFQG-----------LRDALDSEHTRRKHCERHIQSLQTR---VLELQQQLAVAVA 223
L D +G LR L + R+ E +Q L+ + ++ + V
Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592
Query: 224 ADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQ 283
R + ++ + LA ++ ++ E LR +E+ QAA+ +Q++ RLE+
Sbjct: 593 RLRSANELLSREKSNLAHSLQ----VAQQQAEELRQEREKLQAAQEELRRQRD---RLEE 645
Query: 284 SLSEAMEALNREQESARLQQRERETLEEERQAL--------------TLRLEAEQQRCCV 329
+A++ R + R+ E LE +R L TL+ + Q
Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705
Query: 330 LQEERDAARAGQLSEHRELETLRA----------ALEEERQTWAQQEHQLKEHYQALQEE 379
+ E A AG++ + LRA L ++ AQ + L L+EE
Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765
Query: 380 SQAQLEREKEKSQREAQAAWETQHQL--ALVQSEVRR--LEGELDTARRERDALQLEMSL 435
A L+ + ++++EA A E Q +L ++ EV R LEG L A + ++A LE L
Sbjct: 766 KSA-LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA--LEQQL 822
Query: 436 VQARYESQRIQLE-SELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQ 494
R+E ++Q + ++L+ QL R E L QA+ + RQ +L + + + ++
Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQE-LEQARREAQRQVEAL---------ERAAREKE 872
Query: 495 ELASQLAQFKVEMAEREERQQQVAED-YELRLARE--QARVCELQSGNQQLEEQRVELVE 551
LA + A V++ E + ++E+ LRL +E + + E+Q QLE +R +L
Sbjct: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932
Query: 552 RLQAMLQA 559
QA+L A
Sbjct: 933 EGQALLLA 940
Score = 75.1 bits (183), Expect = 3e-13
Identities = 113/396 (28%), Positives = 170/396 (42%), Gaps = 80/396 (20%)
Query: 188 DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247
+AL R E + L+ LQ L+ + L+++LA+ N
Sbjct: 708 EALTKAEAGRVELELSMTKLRAEEASLQDSLS-----------KLSALNESLAQDKLDLN 756
Query: 248 RHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQE--------SA 299
R A+ E LQ + AE Q+ TV R EQ E +E L EQE S
Sbjct: 757 RLVAQLEEEKSALQGRQRQAE-----QEATVAREEQ---ERLEELRLEQEVARQGLEGSL 808
Query: 300 RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER 359
R+ ++ +E LE+ Q TLR E Q LQE+ A+ + RE E +A E +R
Sbjct: 809 RVAEQAQEALEQ--QLPTLRHERSQ-----LQEQ--LAQLSRQLSGREQELEQARREAQR 859
Query: 360 QTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGEL 419
Q E+ + REKE +E QL + E R L E
Sbjct: 860 QV-----------------EALERAAREKEALAKEHAG---LAVQLVAAEREGRTLSEEA 899
Query: 420 DTARRERDALQLEMSLVQ---ARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAAS 476
R E++AL+ + VQ A+ E++R QLE+E + L A+E+ + A
Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE---------GQALLLAKETLTGELAG 950
Query: 477 LREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREE----RQQQVAEDYEL-RLARE-QA 530
LR+ Q ++ Q + L +L K+ AERE R+Q+ A + +L RL RE +A
Sbjct: 951 LRQ------QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA 1004
Query: 531 RVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
EL++ QL+ Q E L A L+A +E ++
Sbjct: 1005 AWRELEAERAQLQSQLQREQEELLARLEAEKEELSE 1040
Score = 68.6 bits (166), Expect = 3e-11
Identities = 130/514 (25%), Positives = 198/514 (38%), Gaps = 80/514 (15%)
Query: 74 ELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREE 133
E +R+ + L L +G E E R ++Q ++ R L G G R
Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451
Query: 134 DSFDSDSTATLLNTRPLQDLSPSSSAQALE-----ELFPRYTSLRPGPPLNP--PDF--Q 184
+ + P +D S + L E P PGP +P PD +
Sbjct: 1452 PA------PRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPE 1505
Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE 244
+R AL + +R L+T+ L +QLA A + QL K +A
Sbjct: 1506 AVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE--- 1562
Query: 245 GWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR 304
EA R+ ++ LS L ++ES R +R
Sbjct: 1563 ---SEEARRS--------------------------VDGRLSGVQAELALQEESVRRSER 1593
Query: 305 ERE-------TLEEERQALTLRLEAEQQRCCVLQE-----ERDAARAGQL---SEHR--E 347
ER TLE QA L A Q++ ++ E D R ++ SE R +
Sbjct: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653
Query: 348 LETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLAL 407
LE R +LE E Q + QALQ+ + L+R+ S+ +A T +L
Sbjct: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDS-LQRQVADSEVKAGTLQLTVERLNG 1712
Query: 408 VQSEVRRLEGEL-DTARRERDAL-QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ 465
++V EG L D R +AL Q SL R ++ +Q Q + ERL
Sbjct: 1713 ALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDA 1772
Query: 466 AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
A RQA S RKQ L G+ Q L ++A +++ E E + QQ+ E R
Sbjct: 1773 A-----RQALS---EARKQSSSL-GEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823
Query: 526 AREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
E A + + Q+L+++R L ERL ++ +A
Sbjct: 1824 EGEAAALNTV----QKLQDERRLLQERLGSLQRA 1853
Score = 62.0 bits (149), Expect = 2e-09
Identities = 135/643 (20%), Positives = 242/643 (37%), Gaps = 94/643 (14%)
Query: 27 LNQVSSEVTSQLYASLRLSRQAEATAR--AQLYLPSTSPPHEG----------------L 68
L Q E Q+ A R +R+ EA A+ A L + + EG L
Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909
Query: 69 DGFAQELSRSLS-VGLEKNLKKKDGSKHIFEMESVRGQLQTMLQ---TSRDTAYRDPLIP 124
+G E+ R L+ + + + +G + E++ G+L + Q +++ A D +
Sbjct: 910 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969
Query: 125 GAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQ 184
+ E ++ S + LQ L A A EL L Q
Sbjct: 970 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA-AWRELEAERAQL-----------Q 1017
Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTM-IEQLDKTLARVV 243
E R E+ S + L+ ++ + +A K+ + +++ +KT
Sbjct: 1018 SQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK 1077
Query: 244 EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAME-----ALNREQES 298
RH + ++ + + A+ + + + TV L L + A QE
Sbjct: 1078 LMGTRHSLATISL--EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEV 1135
Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358
RLQ++ R+ L ++R + E + + +L++ RD R L R+L + E +
Sbjct: 1136 RRLQEQARD-LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194
Query: 359 RQTWAQQEHQL------KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQ--- 409
RQ + L +E + EE ++ +++ + + A + + +LAL++
Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ---- 465
+ V + GEL T +E +E S ++AR E Q ++ + ++ R+ LA+
Sbjct: 1255 TAVGKEAGELRTGLQE-----VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGR 1309
Query: 466 ------AQESSLRQAASLREHHRKQLQDLSGQHQQ------ELASQLAQFK--------- 504
A++ S R+ LR+ K L Q+ +L Q +F+
Sbjct: 1310 LALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS 1369
Query: 505 VEMAEREERQQ-QVAEDYELRLAREQARVCEL------QSGNQQLEEQRVELVERLQAML 557
+E A E+QQ A EL+L +A EL G Q E + VE +
Sbjct: 1370 LEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAA 1429
Query: 558 QAHWDEANQLLSTTL-----PPPNPPAPPAGPSSPGPQEPEKE 595
+A L L P P P P P+ P E E
Sbjct: 1430 EAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472
Score = 54.7 bits (130), Expect = 4e-07
Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 9/176 (5%)
Query: 402 QHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE-SELAVQLEQRVT 460
Q + L+Q E+ R+E L +R ERD L ++ + V R E Q ++LE EL Q + +
Sbjct: 80 QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLE-QALRLEPGELETQEPRGLV 138
Query: 461 ERLAQAQESSLRQAASLREHHR--KQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVA 518
+ + + + AS R + ++ Q Q Q L ++ Q+K +E E++ + +
Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198
Query: 519 EDYELRLAREQARVCELQSGNQQLEE--QRVELVERLQAMLQAHWDE---ANQLLS 569
+ E + R+ +L+S +LEE QR + ++ AML+ D+ ANQ LS
Sbjct: 199 GELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALS 254
Score = 53.9 bits (128), Expect = 7e-07
Identities = 108/437 (24%), Positives = 179/437 (40%), Gaps = 77/437 (17%)
Query: 151 QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTR 210
QD +S + E+ R S P L P +L E+ + ++ L +
Sbjct: 40 QDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQ 99
Query: 211 VLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER------TEVLRGLQEEH 264
+ +LA+ K + + E+L++ L R+ G + R E+ R LQEE
Sbjct: 100 SRAERDELAI------KYNAVSERLEQAL-RLEPGELETQEPRGLVRQSVELRRQLQEEQ 152
Query: 265 -------QAAELTRSKQQETVTRLEQSLSE------AMEALNREQESARLQQRERETLE- 310
QA + + +Q + V RL+ + + +E E+ QQR R+T
Sbjct: 153 ASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHS 212
Query: 311 EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLK 370
++ ++ +RLE EQQR L + R + L + + W + +L
Sbjct: 213 QDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKEL- 271
Query: 371 EHYQALQEESQAQLEREKEKSQREAQAAWETQH-QLALVQSEV---RRLEGELDTARRER 426
E +A RE+E A + +H +L L+ +V RRL E+ ER
Sbjct: 272 -------EHREAAWRREEE----SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF-TER 319
Query: 427 DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486
D LQL L + + R E+ L + R+ E A E++L + A L+ +QL+
Sbjct: 320 DLLQLGGELAR----TSRAVQEAGLGLSTGLRLAESRA---EAALEKQALLQAQLEEQLR 372
Query: 487 DLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQR 546
D KV + E++ QQQ+ D L A ARV EL ++LE+Q
Sbjct: 373 D----------------KV-LREKDLAQQQMQSD--LDKADLSARVTELGLAVKRLEKQN 413
Query: 547 VE-------LVERLQAM 556
+E L E+L+A+
Sbjct: 414 LEKDQVNKDLTEKLEAL 430
Score = 52.8 bits (125), Expect = 1e-06
Identities = 112/441 (25%), Positives = 179/441 (40%), Gaps = 90/441 (20%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ-LDKTLARVVEGWNRHEAERTE 255
+K C Q L R EL+QQ R +DT Q L+ L R+ E R A +
Sbjct: 184 KKRCSELEQQLLERSGELEQQ--------RLRDTEHSQDLESALIRLEEEQQR-SASLAQ 234
Query: 256 VLRGLQEEHQAAELTRSKQQETV-------TRLEQSLSEAMEALNREQES---------A 299
V L+E+ A E + TR + L A RE+ES +
Sbjct: 235 VNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHS 294
Query: 300 RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQ-----LSEHRELETLRA- 353
RL R+ + R +++ E+ + E +RA Q LS L RA
Sbjct: 295 RLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE 354
Query: 354 -ALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEV 412
ALE++ AQ E QL++ ++ +Q Q++ + +K+ A+ T+ LA V
Sbjct: 355 AALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARV---TELGLA-----V 406
Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQ----LESELAVQLEQRVTERLAQA-- 466
+RLE + E+D + +++ ES R+Q LE+E L+Q + + LAQA
Sbjct: 407 KRLEKQ----NLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRD-LAQAVL 461
Query: 467 --QESSLRQAASLR--EHHRKQLQDLSGQHQQEL----------------------ASQL 500
ES ++ + S R + L+ LSGQ +S L
Sbjct: 462 SDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTL 521
Query: 501 AQFKVEMAEREERQQQVAEDYELR---LAREQARVCELQSGNQQLEEQRVELVERLQAML 557
A + +R+ + Q + YE L + ++ + +S + LEEQ L ++ +
Sbjct: 522 ALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 581
Query: 558 QAHWD---------EANQLLS 569
QAH D AN+LLS
Sbjct: 582 QAHEDAQREVQRLRSANELLS 602
>gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens]
Length = 1133
Score = 85.9 bits (211), Expect = 2e-16
Identities = 111/440 (25%), Positives = 187/440 (42%), Gaps = 72/440 (16%)
Query: 203 HIQSLQTRVLELQQQLAVAVAAD---RKKDTMIEQLDKTLARVVEGWNRHEA-------- 251
H + LQ L +++ A +A R +++I Q++K + + E +R EA
Sbjct: 708 HEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQE 767
Query: 252 ------ERTEVLRGLQE----EHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
+R E LR LQE + + E RS+QQE + ++E L+E L +E+
Sbjct: 768 RELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTA 827
Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
+Q + E+++ L+E+R E ELE ++AL EE+++
Sbjct: 828 EQSKAESMQR-----------------ALEEQRKVTAQQMAMERAELERAKSALLEEQKS 870
Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
+ + + A E AQ + KE+++REA+ A + Q EG L +
Sbjct: 871 VMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQ----------REGTLIS 920
Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
+E+ L++ S ++A + QL +E A ++R RL E A +LR
Sbjct: 921 LAKEQAELKIRASELRA----EEKQLAAERAALEQERQELRL----EKERINATALRVKL 972
Query: 482 RKQLQDLSGQHQQELASQLAQFKVEMAEREERQ-QQVAEDYELRLAREQARVCELQSGNQ 540
R + + E S++A K E ER R+ QQV + + RL Q + L+ Q
Sbjct: 973 RAE--------EVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024
Query: 541 QLEEQRVELV-ERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRV 599
+ ++ + L +RLQ D A Q L ++L P A SS P R
Sbjct: 1025 HMHQEHLSLAQQRLQL------DRARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRW 1078
Query: 600 WTMPPMAVALKPVLQQSREA 619
+ PP + P+ +R A
Sbjct: 1079 CSQPPTGLDPSPLHLHARLA 1098
Score = 64.3 bits (155), Expect = 5e-10
Identities = 109/445 (24%), Positives = 176/445 (39%), Gaps = 91/445 (20%)
Query: 174 PGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIE 233
P PL P R L S +++ +Q LQ ELQ +L + A + + +
Sbjct: 541 PVQPLLPESLA--RSLLPSTEYQKQLLAAQVQ-LQCSPAELQAELLHSQARLAELEAQVR 597
Query: 234 QLDKTLARVVEGWNRHEAERTEVLRGLQEEHQA-AELTRSKQQETVTRLEQSLSEAMEAL 292
+L+ A+ HE +L LQ++HQA EL S + + LE S + E L
Sbjct: 598 KLELERAQ-------HEL----LLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERL 646
Query: 293 NREQESARLQQRERETLEEERQALTLRLEAEQQR-----------CCVLQEE-------R 334
RE E E + L+ EAEQ R + QE+ R
Sbjct: 647 RRENE------------ELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLR 694
Query: 335 DAARAGQLSEHR--ELETLRAALEEERQTWAQQE------------HQLKEHYQALQEES 380
+ RA L R E + R L ++R+ A HQ+++ +L E S
Sbjct: 695 ELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELS 754
Query: 381 QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY 440
SQ + QL +Q + + + +++ ER Q + ++AR
Sbjct: 755 SRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDME---EERSRQQEVIGKMEARL 811
Query: 441 ESQRIQLESE---------------LAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485
Q LE E A++ +++VT + + + L +A S +K +
Sbjct: 812 NEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSV 871
Query: 486 QDLSGQHQQELASQLAQFKV------EMAERE-ERQQQVAEDYE---LRLAREQA----R 531
G+ ++ LA++ A+F E AERE ER QV E + LA+EQA R
Sbjct: 872 MLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIR 931
Query: 532 VCELQSGNQQLEEQRVELVERLQAM 556
EL++ +QL +R L + Q +
Sbjct: 932 ASELRAEEKQLAAERAALEQERQEL 956
Score = 32.7 bits (73), Expect = 1.6
Identities = 24/76 (31%), Positives = 38/76 (50%), Gaps = 4/76 (5%)
Query: 495 ELASQLAQFKVEMAERE----ERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELV 550
EL +Q+ + ++E A+ E QQQ D EL + ++R+ L++ QQ EE+
Sbjct: 591 ELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRREN 650
Query: 551 ERLQAMLQAHWDEANQ 566
E L A + EA Q
Sbjct: 651 EELSARYLSQCQEAEQ 666
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 85.5 bits (210), Expect = 2e-16
Identities = 121/474 (25%), Positives = 212/474 (44%), Gaps = 68/474 (14%)
Query: 125 GAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQ 184
G+ E R E S DS ++ P Q+ + S LF R GP L +
Sbjct: 1194 GSVCESRPELSGGGDSAPSVWGLEPDQNGARS--------LFKR------GPLLTALSAE 1239
Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE 244
+ AL H ++ L+ +V +L+++L A + T ++ L + L++ E
Sbjct: 1240 AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE 1299
Query: 245 GWNRHEAERT----------EVLRGLQEEHQAAELTRSKQQ---ETVTRLEQSLSEAMEA 291
++ E ++ E + LQ + AEL R + Q E + +++L+ +E
Sbjct: 1300 EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEH 1359
Query: 292 LNREQESARLQQRERETLEEE----RQALTLR---LEAEQQRCCVLQEERD--AARAGQL 342
L AR Q LEE+ R AL L+ +E+E++R LQE+ + A+ L
Sbjct: 1360 LQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKAL 1419
Query: 343 SEH------------RELETLRAALEE-ERQTWAQQEH------QLKEHYQA--LQEESQ 381
E+ E+ETLR ++E E+Q Q+ LK+ Q LQ+E
Sbjct: 1420 QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479
Query: 382 AQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE 441
+LE+ + + A E + +L + + ++R LE + +T R + LE+ E
Sbjct: 1480 QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539
Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501
SQR Q++ +L QL E LA E + + E +K +++L GQ + + + L
Sbjct: 1540 SQRGQVQ-DLKKQLV--TLECLALELEENHHK----MECQQKLIKELEGQRETQRVA-LT 1591
Query: 502 QFKVEMAER-EERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
+++ ER +E Q Q ++ ++L + ELQ +Q+++ QR E +E LQ
Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLE-SHSTVLARELQERDQEVKSQR-EQIEELQ 1643
Score = 85.1 bits (209), Expect = 3e-16
Identities = 122/456 (26%), Positives = 200/456 (43%), Gaps = 87/456 (19%)
Query: 182 DFQGLRDALDSE----HTRRKHCERHIQSLQTRVLELQQQLAVA-VAADRKKDTMIEQLD 236
+ Q L+D L+ + H + + + ++ LQQQL A + K+ ++ QLD
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
Query: 237 KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQ 296
+ R A+R + L LQ+E Q A+ + +E L+ +L +A L
Sbjct: 1807 EA--------QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858
Query: 297 ESARLQQRERETLEEER-------QAL-----TLRLEAEQQRCCVLQEERDAARAGQLSE 344
+ + + LEEE QAL LR E+ +Q +L ++ A Q E
Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE--QAQE 1916
Query: 345 HRELETLRAALEEERQTWAQQEHQLKEHYQ---ALQEESQAQLEREKEKSQR-------- 393
H E+ET AL++ +W Q + LKE Q AL+ ESQ+ +E+ R
Sbjct: 1917 H-EVET--RALQD---SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEAL 1970
Query: 394 -EAQAAWETQHQLALVQSEV-RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
+A AA + + Q L Q+E+ R LE T + DA Q ++ E+ RIQ E E+
Sbjct: 1971 GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE---EALRIQ-EGEI 2026
Query: 452 AVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA-ER 510
Q + R E + Q Q++ ++ LR H +++ Q L Q + + Q K + ER
Sbjct: 2027 QDQ-DLRYQEDVQQLQQALAQRDEELR-HQQEREQLLEKSLAQRVQENMIQEKQNLGQER 2084
Query: 511 EERQ----QQVAEDYELRLAREQARVCELQSGNQQ--------------LEEQRVEL--- 549
EE + Q + +L LA+++ + EL+ Q+ +EEQ ++L
Sbjct: 2085 EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144
Query: 550 -------VERLQAML------QAHWDEANQLLSTTL 572
+ERLQA L + W E Q L+ +L
Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSL 2180
Score = 84.0 bits (206), Expect = 6e-16
Identities = 115/482 (23%), Positives = 214/482 (44%), Gaps = 66/482 (13%)
Query: 147 TRPLQDLSPSSSAQA--LEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHI 204
T L++ S AQ+ + +L T L + + R+ ++ +++H + +
Sbjct: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL 1653
Query: 205 QSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEH 264
+ + + L LQ++ + R + T I L++ L ++ E T + +QE
Sbjct: 1654 ER-RDQELMLQKERIQVLEDQRTRQTKI--LEEDLEQIKLSLRERGRELTTQRQLMQERA 1710
Query: 265 QAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQAL-------T 317
+ + Q+ ++ ++ L + + + +QE Q ++ LE++ Q L +
Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770
Query: 318 LRLEAEQQRCCVLQEE-RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQAL 376
L L +Q VLQ++ ++A G+L E ++L++ L+E ++ AQ++ +L E Q
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKE----QSLQSQLDEAQRALAQRDQEL-EALQQE 1825
Query: 377 QEESQAQLEREKEKSQREAQAAWETQH--------QLALVQSEVRRLEGELDTARRERDA 428
Q+++Q Q ER KEK+ Q A E H +L + + RRLE EL R A
Sbjct: 1826 QQQAQGQEERVKEKAD-ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA 1884
Query: 429 LQLEMSLVQARYESQR---IQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK-- 483
L+ + ++A Q + L+ + A Q ++ E A Q+S L+ A L+E ++
Sbjct: 1885 LEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA-LQDSWLQAQAVLKERDQELE 1943
Query: 484 --QLQDLSGQHQQELASQLAQFKVEM-----AEREERQQQVAEDYELRLARE------QA 530
+ + S +HQ+E A A+ E A + ++Q + E EL + E QA
Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003
Query: 531 RVCELQSGNQQLEE-----------QRVELVERLQAMLQA---------HWDEANQLLST 570
+ Q+ ++QLEE Q + E +Q + QA H E QLL
Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEK 2063
Query: 571 TL 572
+L
Sbjct: 2064 SL 2065
Score = 83.2 bits (204), Expect = 1e-15
Identities = 96/400 (24%), Positives = 185/400 (46%), Gaps = 38/400 (9%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ---LDKTLARVVEGW 246
L E + C R + Q R LQ LA A+++++ + E+ L+ L + E
Sbjct: 620 LQLEEENQSVCSRMEAAEQARNA-LQVDLA---EAEKRREALWEKNTHLEAQLQKAEEAG 675
Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306
+A+ ++ +E + +R +Q+ T+LEQ EA R++E +E+
Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA----KRQEEVLARAVQEK 731
Query: 307 ETLEEERQALTLRLEA-EQQRCCVLQEERDAARAGQLSE---------HRELETLRAALE 356
E L E+ AL +RL+A E+ R + ++ + + A +L E + +E + LE
Sbjct: 732 EALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791
Query: 357 EERQTWAQQEHQLKEHYQALQ-----EESQAQLERE---KEKSQREAQAAWETQHQLALV 408
+ QT Q + ++ + L+ E SQA+ ER+ ++ +Q E + + Q A
Sbjct: 792 VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH 851
Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE 468
+ EV +L + + +ER Q E++ E ++++LE L EQ+ QAQ
Sbjct: 852 EKEVNQLREKWE---KERSWHQQELAKALESLEREKMELEMRLK---EQQTEMEAIQAQR 905
Query: 469 SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528
R A E Q+Q + + + L L Q + E+A+ ++ +++ +D +++ +E
Sbjct: 906 EEERTQA---ESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962
Query: 529 QARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568
Q LQ+ Q+ + + E + + L A +E++ LL
Sbjct: 963 QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002
Score = 80.9 bits (198), Expect = 5e-15
Identities = 112/474 (23%), Positives = 201/474 (42%), Gaps = 52/474 (10%)
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEG---WNRHEAERTEVL 257
E+ ++ Q + ELQ+ KD + +QL +V E ++ E E +
Sbjct: 1735 EKEVECQQEHIHELQEL----------KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784
Query: 258 RGLQEEHQAAELTRSKQQETVTRLEQSLSEA---MEALNREQESARLQQRERETLEEERQ 314
+ LQE + EL Q + +++L++ +EAL +EQ+ A Q + E ++E+
Sbjct: 1785 QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA---QGQEERVKEKAD 1841
Query: 315 ALTLRLEAE----QQRCCVLQEERDAARAGQLSEHRELETLRA-ALEEERQTWAQQEHQL 369
AL LE ++R LQ+ ++ AR +L E +E R ALEE + +
Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQAR--RLEEELAVEGRRVQALEEVLGDLRAESREQ 1899
Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAW-ETQHQLALVQSEVRRLEGELDTARRERDA 428
++ ALQ++ A+ +E E R Q +W + Q L E+ L E ++R + +A
Sbjct: 1900 EKALLALQQQC-AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA 1958
Query: 429 LQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL--- 485
+ +Q L+ + LEQ R +A ++L+ + + H +QL
Sbjct: 1959 ARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEA 2018
Query: 486 ----------QDLSGQHQ-QELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCE 534
QDL Q Q+L LAQ E+ ++ER+Q + + R+ ++ + E
Sbjct: 2019 LRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV--QENMIQE 2076
Query: 535 LQSGNQQLEEQRV----ELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQ 590
Q+ Q+ EE+ + + V LQ L E +L T P + +SP +
Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136
Query: 591 EPEK----EERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLL 640
+ K E R + + AL+ + E R++ L + + +S L
Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190
Score = 79.0 bits (193), Expect = 2e-14
Identities = 103/405 (25%), Positives = 191/405 (47%), Gaps = 68/405 (16%)
Query: 204 IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR---GL 260
++ +Q E+Q++L+ + T +EQL + R E R E+ ++R L
Sbjct: 682 LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741
Query: 261 QEEHQAAELTRSKQQETVTRL-------EQSLSEAMEA-----LNREQESARLQQ--RER 306
+ QA E R E + L E SL EA + + + Q ++Q + +
Sbjct: 742 EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801
Query: 307 ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE 366
E ++ E + L L L+ E+ + ++ERDAA +E +T ALE+++ ++
Sbjct: 802 EVIQGEVRCLKLELDTERSQA---EQERDAAARQLAQAEQEGKT---ALEQQKAAHEKEV 855
Query: 367 HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426
+QL+E ++ + Q +L + E +RE E + +L Q+E+ ++ A+RE
Sbjct: 856 NQLREKWEKERSWHQQELAKALESLEREKM---ELEMRLKEQQTEMEAIQ-----AQREE 907
Query: 427 DALQLEMSLVQARYESQR---------IQLESELAVQLEQRVTERLAQ--------AQES 469
+ Q E +L Q + E+++ +Q + ELA +Q ERL Q QE+
Sbjct: 908 ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ--LERLRQDMKVQKLKEQET 965
Query: 470 SLRQAASLREHHRKQLQDLSGQHQQELA------SQLAQFKVEMAEREE--RQQQVAEDY 521
+ L+E R +L++ + QH+ +LA S L Q K+++ ++ E + Q VA+D
Sbjct: 966 TGILQTQLQEAQR-ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024
Query: 522 ELRLARE--QARVCELQSGN---QQLEEQR----VELVERLQAML 557
RL + Q ++ E Q N ++LE ++ + L+E+ Q +L
Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069
Score = 77.8 bits (190), Expect = 4e-14
Identities = 115/530 (21%), Positives = 226/530 (42%), Gaps = 63/530 (11%)
Query: 27 LNQVSSEVTSQLYASLRLSRQAEATARA----QLYLPSTSPPHEGLDGFAQELSRSLSVG 82
L Q+ E Q R ++ EA R ++ L + + L Q LS + +
Sbjct: 710 LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL- 768
Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTA 142
LE +L + + E+ +GQL+ +QT T ++ + + E D+ S +
Sbjct: 769 LESSLFEAQQQNSVIEV--TKGQLEVQIQTV--TQAKEVIQGEVRCLKLELDTERSQAEQ 824
Query: 143 TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHT-RRKHCE 201
+D + AQA +E T+L + + LR+ + E + ++
Sbjct: 825 E-------RDAAARQLAQAEQE---GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELA 874
Query: 202 RHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQ 261
+ ++SL+ +EL+ +L +++ T +E + + E ERT+ L
Sbjct: 875 KALESLEREKMELEMRL-------KEQQTEMEAIQA----------QREEERTQAESALC 917
Query: 262 EEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ-RERET-------LEEER 313
+ E R ET+ + ++ L++A + L R ++ ++Q+ +E+ET L+E +
Sbjct: 918 QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977
Query: 314 QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHY 373
+ L + LQEE + ++ +++E L++ L + + E +++E
Sbjct: 978 RELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037
Query: 374 QALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEM 433
+ QE ++ Q E E+EK+ L+L++ E R L + + R+++ L
Sbjct: 1038 RETQEYNRIQKELEREKASL----------TLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087
Query: 434 SLVQARYESQRIQLESELAVQLEQRVTERLAQ--AQESSLRQAASLREHHRKQLQDLSGQ 491
+ +A+ E + + + EL L Q V E+ A AQE+ L + L H + Q +
Sbjct: 1088 DMQEAQGEQKELSAQMEL---LRQEVKEKEADFLAQEAQLLE--ELEASHITEQQLRASL 1142
Query: 492 HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQ 541
QE + Q ++ E + + AE A+ QA++ L S QQ
Sbjct: 1143 WAQEAKAAQLQLRLRSTE-SQLEALAAEQQPGNQAQAQAQLASLYSALQQ 1191
Score = 74.7 bits (182), Expect = 4e-13
Identities = 100/416 (24%), Positives = 180/416 (43%), Gaps = 45/416 (10%)
Query: 224 ADRKKDTMIEQL----DKTLARVVEGWNR----HEAERTEVLRGLQEEHQAAELTRSKQQ 275
A+++ T +EQ +K + ++ E W + H+ E + L L+ E E+ R K+Q
Sbjct: 836 AEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEM-RLKEQ 894
Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV---LQE 332
+T E +A R Q + L Q + ET +E L L+ +++ L+
Sbjct: 895 QT----EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER 950
Query: 333 ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQ 392
R + +L E L+ L+E ++ + Q ++ ALQEES + L+ +K Q
Sbjct: 951 LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ-DKMDLQ 1009
Query: 393 REAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELA 452
++ + + + QL R +E E+ RE E + +Q E ++ L L
Sbjct: 1010 KQVE---DLKSQLVAQDDSQRLVEQEVQEKLRETQ----EYNRIQKELEREKASLTLSL- 1061
Query: 453 VQLEQRV-----TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507
++ EQR+ + + Q + S+LRQ + +K+L +QE+ + A F +
Sbjct: 1062 MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121
Query: 508 AER-EERQQQVAEDYELR--LAREQARVCELQ----SGNQQLE----EQRVELVERLQAM 556
A+ EE + + +LR L ++A+ +LQ S QLE EQ+ + QA
Sbjct: 1122 AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ 1181
Query: 557 LQAHWDEANQLLSTTLPPPNPPAPPAGPSSP---GPQEPEKEERRVWTMPPMAVAL 609
L + + Q L + P G S+P G + + R ++ P+ AL
Sbjct: 1182 LASLYSALQQALGSVC-ESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTAL 1236
Score = 70.9 bits (172), Expect = 5e-12
Identities = 94/380 (24%), Positives = 167/380 (43%), Gaps = 48/380 (12%)
Query: 204 IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV--EGWNRHEAERTEVLRGL- 260
++ L+T EL + A +++ ++Q+ K + +V+ EG N + E L
Sbjct: 313 VEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELD 372
Query: 261 -----QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA 315
Q ++Q A+ + + +TR Q++ + + L QE+ L Q++ + EEE +A
Sbjct: 373 SSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKA 432
Query: 316 LTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQA 375
L RL+ L ERD + E++ +L +ER+ + +L++ +
Sbjct: 433 LRQRLQK-------LTGERDTLAGQTVDLQGEVD----SLSKERELLQKAREELRQQLEV 481
Query: 376 LQEES--------QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427
L++E+ + QL+ + + Q+E E Q +L L E RL+ L ++
Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQKE-----EQQEELHLAVRERERLQEMLMGLEAKQS 536
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487
E+ ++ ES LE EL Q + VT LA+A E S+ + +S + ++ D
Sbjct: 537 ESLSELITLREALESS--HLEGELLRQEQTEVTAALARA-EQSIAELSSSENTLKTEVAD 593
Query: 488 LSGQH------QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQ 541
L + LA ++ + EE Q V E A EQAR LQ +
Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRME---AAEQARNA-LQVDLAE 649
Query: 542 LEEQRVELVER---LQAMLQ 558
E++R L E+ L+A LQ
Sbjct: 650 AEKRREALWEKNTHLEAQLQ 669
Score = 62.4 bits (150), Expect = 2e-09
Identities = 124/574 (21%), Positives = 223/574 (38%), Gaps = 80/574 (13%)
Query: 29 QVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSP---PHEGLDGFAQELSRSLSVGLEK 85
++ E Q+ SLR R E T + QL P + G + + L +K
Sbjct: 1679 KILEEDLEQIKLSLR-ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILR---DK 1734
Query: 86 NLKKKDGSKHIFEMESVRGQLQTMLQ--------TSRDTAYRDP---LIPGAGSERREED 134
+ + +HI E++ ++ QL+ LQ TS + R+ ++ E RE+
Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794
Query: 135 SFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEH 194
S + L+ + + Q LE L + L+ AL+ H
Sbjct: 1795 ELKEQSLQSQLDEA---QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAH 1851
Query: 195 TRRKHCERHIQSLQTRVLELQQQLAVAV--------------AADRKKDTMIEQLDKTLA 240
K +Q + + L+++LAV A R+++ + L + A
Sbjct: 1852 MTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCA 1911
Query: 241 R-----------VVEGWNRHEA---ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS 286
+ + W + +A ER + L L+ E Q++ + L+++L
Sbjct: 1912 EQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971
Query: 287 EAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE----ERDAARAGQL 342
+A AL +++ Q +LE L L+A Q L+E + + L
Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031
Query: 343 SEHRELETLRAAL--EEERQTWAQQEHQLKEHYQA-------LQEESQAQLEREKEKSQR 393
+++ L+ AL +E Q+ QL E A +QE+ ERE+E+ +
Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091
Query: 394 EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV 453
Q+ E Q LA + E+ EL ++ + L S + E Q ++L+S
Sbjct: 2092 LHQSVRELQLTLAQKEQEIL----ELRETQQRNNLEALPHSHKTSPMEEQSLKLDS---- 2143
Query: 454 QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER 513
LE R+ L + Q ++LRQ + R++ QDL A LAQ K ++ +E
Sbjct: 2144 -LEPRLQRELERLQ-AALRQTEAREIEWREKAQDL--------ALSLAQTKASVSSLQEV 2193
Query: 514 QQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547
+ R + +Q EL+ + LE++R+
Sbjct: 2194 AMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227
Score = 60.1 bits (144), Expect = 9e-09
Identities = 105/446 (23%), Positives = 181/446 (40%), Gaps = 102/446 (22%)
Query: 207 LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH----EAERTEVLRGLQE 262
LQ +V +L+ QL + R ++EQ + R + +NR E E+ + L E
Sbjct: 1008 LQKQVEDLKSQLVAQDDSQR----LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063
Query: 263 EHQAAELTR---SKQQETVTRLEQSLSEAM---EALNREQESARLQQRERET--LEEERQ 314
+ Q + + S +Q+ ++ L Q + EA + L+ + E R + +E+E L +E Q
Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123
Query: 315 ALTLRLEA-----EQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
L LEA +Q R + +E AA+ E + A E++ AQ + QL
Sbjct: 1124 LLE-ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182
Query: 370 KEHYQALQEESQAQLEREKEKS--------------------------------QREAQA 397
Y ALQ+ + E E S EA A
Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242
Query: 398 A---------WETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQ----------A 438
+ W+TQ +++ +V++LE L E+ + E+ +Q +
Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302
Query: 439 RYESQRIQLESE----------LAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDL 488
++E ++ LESE L +L + +R+ E L QAA +E+ Q++ L
Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA--KENLTAQVEHL 1360
Query: 489 -------------SGQHQQELASQLAQFKV---EMAEREERQQQVAEDYELRLAREQARV 532
+G +++L + + K+ E+ ER Q + E EL++A+ +A
Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
Query: 533 CELQSGNQQLEEQRVELVERLQAMLQ 558
L Q L E R E VE L+ +Q
Sbjct: 1421 ENLALLTQTLAE-REEEVETLRGQIQ 1445
Score = 47.0 bits (110), Expect = 8e-05
Identities = 86/360 (23%), Positives = 134/360 (37%), Gaps = 56/360 (15%)
Query: 207 LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQA 266
L+ +VL LQQQ+A AA +K L+ QE Q
Sbjct: 20 LEEQVLALQQQMAENQAASWRK----------------------------LKNSQEAQQR 51
Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
K Q V + E + L E + QR E L +RLE EQQR
Sbjct: 52 QATLVRKLQAKVLQYRSWCQELEKRL--EATGGPIPQRWENVEEPNLDELLVRLEEEQQR 109
Query: 327 CCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLER 386
C L E R + LR +E+ W++ +L +++ESQ Q+E+
Sbjct: 110 CESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDEL------MRKESQWQMEQ 163
Query: 387 EKEKSQREAQAAWETQHQLALVQSEV--RRLEGELDTARRERDALQLEMSLVQARYESQR 444
E K + E L+L + V RR E+ +A +RD ++L+ V R
Sbjct: 164 EFFKGYLKG----EHGRLLSLWREVVTFRRHFLEMKSA-TDRDLMELKAEHV--RLSGSL 216
Query: 445 IQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
+ L V + R + Q L ++L+ + + QEL +Q
Sbjct: 217 LTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA-KTQELEKEAHERSQELIQLKSQGD 275
Query: 505 VEMAEREER----------QQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
+E AE ++R Q+ EDYE + + V L++ + +L E L Q
Sbjct: 276 LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQ 335
Score = 43.9 bits (102), Expect = 7e-04
Identities = 110/474 (23%), Positives = 186/474 (39%), Gaps = 59/474 (12%)
Query: 38 LYASLRLSRQAE--ATARAQLYLPSTSPPHEGLDGFAQ------ELSRSLSVGLEKNLKK 89
L A + SR E A ARA+ + H L G Q ELSRSL
Sbjct: 1945 LRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQAS 2004
Query: 90 KDGSK-HIFEMESV----RGQLQTM-LQTSRDTAYRDPLIPGAGSERR---EEDSFDSDS 140
D + H ++E G++Q L+ D + E R E + S
Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064
Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTR-RKH 199
A + +Q+ + EE+ + S+R L Q ++ L+ T+ R +
Sbjct: 2065 LAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE---LQLTLAQKEQEILELRETQQRNN 2121
Query: 200 CERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRG 259
E S +T +E Q K D++ +L + L R+ + EA E
Sbjct: 2122 LEALPHSHKTSPMEEQSL---------KLDSLEPRLQRELERLQAALRQTEAREIE---- 2168
Query: 260 LQEEHQAAELTRSKQQETVTRLEQ-SLSEAMEALNREQESARLQQR---ERETLEEER-- 313
+E+ Q L+ ++ + +V+ L++ ++ L R+ E RLQ R LE+ER
Sbjct: 2169 WREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLH 2228
Query: 314 ---QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE---H 367
T L + ++ L E A + E ++ R LE +Q A+ E
Sbjct: 2229 SPGATSTAELGSRGEQGVQLGEV-SGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS 2287
Query: 368 QLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427
+L+ H L+ + Q+ERE+ K +REA A + E+ + T + R
Sbjct: 2288 RLQRHNVQLRSTLE-QVERERRKLKREAMRAAQAG------SLEISKATASSPTQQDGRG 2340
Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
+ V A + + + L+++L ++ +Q+ AQ S R+ A L HH
Sbjct: 2341 QKNSDAKCV-AELQKEVVLLQAQLTLERKQKQDYITRSAQTS--RELAGL--HH 2389
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 85.1 bits (209), Expect = 3e-16
Identities = 86/389 (22%), Positives = 178/389 (45%), Gaps = 34/389 (8%)
Query: 205 QSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEH 264
+ L+ + ELQ++L + + + ++ L + L ER ++L Q+
Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL------------ERAQLLLPQQQLQ 261
Query: 265 QAAELTRSKQQETVTRLEQSL--SEAMEALNREQESARLQQRERETLEEER---QALTLR 319
A+ + Q +L+ + +E LN++QE +Q E+ +EE+ Q L +R
Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321
Query: 320 LEAE----QQRCCVLQEERDAARAGQL--SEHRELETLRAALEEERQTWAQQE--HQLKE 371
+ E Q+ QEE+ + ++ E + E E+E + W Q+E + E
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE 381
Query: 372 HYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQL 431
Q +EE Q E+ +E+ ++ + W + ++ ++R E E+ R+E +L
Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM--WRQEEKIREL 439
Query: 432 EMSL----VQARYESQRIQLESELAVQLE---QRVTERLAQAQESSLRQAASLREHHRKQ 484
E + + R +++Q E E + E QR E++ + +E + RQ L++ +
Sbjct: 440 EEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499
Query: 485 LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
Q+ Q+E + + E E+ +RQ++ + E+RL +++ ++ E + Q+LEE
Sbjct: 500 EQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEE 559
Query: 545 QRVELVERLQAMLQAHWDEANQLLSTTLP 573
+ +L ++ + + A + +Q L T P
Sbjct: 560 RLGKLGQKAELLGGAGRESGSQRLPTLTP 588
Score = 64.7 bits (156), Expect = 4e-10
Identities = 58/295 (19%), Positives = 138/295 (46%), Gaps = 25/295 (8%)
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260
E I+ + ++ E ++++ R++D I++ ++ + R E E +R E +
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320
+++ + + +Q+E + R E+ + E E + ++E R + + + EE+ Q ++
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471
Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEES 380
+ ++++ + ++E R +L + E E+E + W +QE ++ E + +QE+
Sbjct: 472 QRQEEK--IQEQEEKTWRQEKLLKQEE-----KIWEQEEKMW-RQEEKMWEQEEKMQEQE 523
Query: 381 QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY 440
+ +++R++EK + + W+ + ++ + ++ LE L ++ + L
Sbjct: 524 E-KMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELL----GGAGRES 578
Query: 441 ESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQ 494
SQR+ L L V+L+ + + L Q Q +H+R LQ +QQ
Sbjct: 579 GSQRLPTLTPILQVELKSQEAQSLQQQQ-----------DHYRGHLQQYVAAYQQ 622
Score = 64.3 bits (155), Expect = 5e-10
Identities = 74/316 (23%), Positives = 146/316 (46%), Gaps = 40/316 (12%)
Query: 226 RKKDTMIEQLDKTLARVVEGWNRHEA--ERTEVLRGLQEE----HQAAELTRSKQQETVT 279
R+++ + EQ +K + + W + E E+ E ++ +EE + K+QE +
Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Query: 280 RLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARA 339
R E+ + E E + ++E Q+ + LEE Q +L +++ +QEE + +
Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK---MQEEEEKMQE 466
Query: 340 GQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAW 399
+ R+ E ++ E+E +TW +QE LK QEE ++ ++EK R+ + W
Sbjct: 467 QEEKIQRQEEKIQ---EQEEKTW-RQEKLLK------QEE---KIWEQEEKMWRQEEKMW 513
Query: 400 ETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRV 459
E + ++ + +++R E ++ RE+ ++ + + + + Q ++L Q +
Sbjct: 514 EQEEKMQEQEEKMQRQEEKM----REQ---EVRLWQQEEKMQEQEVRL---------QEL 557
Query: 460 TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE--REERQQQV 517
ERL + + + + RE ++L L+ Q EL SQ AQ + + R QQ V
Sbjct: 558 EERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYV 617
Query: 518 AEDYELRLAREQARVC 533
A +L +E C
Sbjct: 618 AAYQQLASGKEALPSC 633
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 84.7 bits (208), Expect = 3e-16
Identities = 120/504 (23%), Positives = 202/504 (40%), Gaps = 52/504 (10%)
Query: 67 GLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGA 126
GL A+E L+ L++ + G +H ++E + L+ Q ++ A
Sbjct: 523 GLKQQAKEKQAQLAQTLQQQEQASQGLRH--QVEQLSSSLKQKEQQLKEVA--------- 571
Query: 127 GSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGL 186
++++ D L ++ S AL++L + Q
Sbjct: 572 ----EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627
Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
+A DS T +R L +V ELQ + A + + +L+ L
Sbjct: 628 NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL------- 680
Query: 247 NRHEAERTEVLRGLQEEHQAAE-LTRSKQQETVTR--LEQSLSEAMEALNREQESARLQQ 303
+ + TE R QE+ Q E L K+ VT+ LE+ A +AL +Q +
Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740
Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363
E +L E+ + LE E+ L+ AR QL E + ET L E
Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLE-----ARLQQLGEAHQAET--EVLRRELAEAM 793
Query: 364 QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423
+H + + L +E A ER ++ Q EAQ A+ Q ++ L+ E + AR
Sbjct: 794 AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG-------AMFQEQLMTLKEECEKAR 846
Query: 424 RERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK 483
+E + +++ +++ E Q + ++ELA +L + L Q QE +R +K
Sbjct: 847 QELQEAKEKVAGIESHSELQISRQQNELA-ELHANLARALQQVQEKEVRA--------QK 897
Query: 484 QLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLE 543
DLS ++ A+ ++E R+ +QQ E L +E AR + Q + LE
Sbjct: 898 LADDLSTLQEKMAATSKEVARLETLVRKAGEQQ--ETASRELVKEPARAGDRQP--EWLE 953
Query: 544 EQRVELVERLQAMLQAHWDEANQL 567
EQ+ QA LQA EA Q+
Sbjct: 954 EQQGRQFCSTQAALQAMEREAEQM 977
Score = 84.3 bits (207), Expect = 5e-16
Identities = 100/418 (23%), Positives = 186/418 (44%), Gaps = 70/418 (16%)
Query: 201 ERHIQSLQTRVLELQ---QQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVL 257
E + L +VLE + ++L V A+ +K +E+ + L + AER+ L
Sbjct: 1231 EEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL 1290
Query: 258 R----GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313
R L+EE + + ++ +T + E + L QE +++ TL+ E
Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350
Query: 314 ---QALTLRLEAEQQRCCVLQEERDAA------------------RAGQLSEHREL---- 348
QAL L + C LQ E+ AA RA L REL
Sbjct: 1351 TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELI 1410
Query: 349 ---------ETLRAALEEERQTWAQQEHQLKEHYQALQEES--------------QAQLE 385
E L E+ ++A+Q LK+ + L EE+ + +L+
Sbjct: 1411 PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD 1470
Query: 386 REKEKSQREAQAAW-ETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQR 444
+ +EK +E A + + +LA VQ E + EL+ + + ++++ + R++ +R
Sbjct: 1471 QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530
Query: 445 IQLESELAVQLEQRVTERLAQAQESSLR-----QAASLREHHRKQLQDLSGQHQQE---L 496
+L +++ QLE E+ Q +E S + QA+ +++ K +Q G+ QQE L
Sbjct: 1531 QKLTAQVE-QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRL 1589
Query: 497 ASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
+QL + + +++++E Q AE Y+L++ + + + NQ+L+EQ + +E+LQ
Sbjct: 1590 QAQLNELQAQLSQKE----QAAEHYKLQMEKAKTHYDAKKQQNQELQEQ-LRSLEQLQ 1642
Score = 81.6 bits (200), Expect = 3e-15
Identities = 95/431 (22%), Positives = 174/431 (40%), Gaps = 32/431 (7%)
Query: 150 LQDLSPSSSAQALEELFPRYTSLRPGPPL--NPPDFQGLRDALDSEH--------TRRKH 199
LQD P + L ++ T + L N Q + L++E R H
Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456
Query: 200 CERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRG 259
E Q L + + +LQ I L + + + H A T +
Sbjct: 457 FEEEKQQLSSLITDLQSS--------------ISNLSQAKEELEQASQAHGARLTAQVAS 502
Query: 260 LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLR 319
L E T +Q + + L+Q E L ++ + Q++ + L + + L+
Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQL---AQTLQQQEQASQGLRHQVEQLSSS 559
Query: 320 LEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379
L+ ++Q+ + E+++A R + R A ER +Q L++ A E
Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619
Query: 380 SQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQAR 439
Q QL+ E + + Q + A + +V L+ ++TAR+E+ Q +++ ++ +
Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679
Query: 440 YES-QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELAS 498
S Q+ E E Q + ++ E+L +ES SL E R+ L + QQ S
Sbjct: 680 LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL--EEQQRCIS 737
Query: 499 QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ-QLEEQRVELVERLQAML 557
+L + E+ +R+++ E+ +AR+ +L +Q + E R EL E + A
Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797
Query: 558 QAHWDEANQLL 568
A E QL+
Sbjct: 798 TAE-SECEQLV 807
Score = 71.6 bits (174), Expect = 3e-12
Identities = 98/412 (23%), Positives = 177/412 (42%), Gaps = 37/412 (8%)
Query: 177 PLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAAD-------RKKD 229
PL P + + LRD +S R + Q L+T ++ +++ + R+
Sbjct: 272 PLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFA 331
Query: 230 TMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAM 289
+ ++QL L + E ++ E E L++E AA + +E L+ LS+
Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391
Query: 290 EALNREQESARLQQRE-------RETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQL 342
E L++ Q++ ++ E ETL++E L Q R +L+ ER A L
Sbjct: 392 EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLL 451
Query: 343 SEHRELETLRAALEEERQTWA----QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAA 398
+E R EEE+Q + + + QA +E QA + + A
Sbjct: 452 AE-------RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504
Query: 399 WETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQR 458
E A +Q + + L G L +E+ A QL +L Q SQ ++ + E QL
Sbjct: 505 SELTTLNATIQQQDQELAG-LKQQAKEKQA-QLAQTLQQQEQASQGLRHQVE---QLSSS 559
Query: 459 VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK-VEMAEREERQQQV 517
+ ++ Q +E + +Q A+ R+ H +QL + + + L + A K +E E+E+ +
Sbjct: 560 LKQKEQQLKEVAEKQEAT-RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618
Query: 518 AEDYELRLAREQARVCELQSGNQQLEEQRVEL---VERLQAMLQAHWDEANQ 566
+L++A E Q+ Q + ++ EL VE LQA ++ E ++
Sbjct: 619 ILQQQLQVANEARD--SAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668
Score = 71.2 bits (173), Expect = 4e-12
Identities = 140/575 (24%), Positives = 233/575 (40%), Gaps = 99/575 (17%)
Query: 49 EATARAQLYLPSTSPPHEGLDGFA---QELSRSLSV--GLEKNLKKKDG--SKHIFEMES 101
E ARA+L + + +E FA + L+ +L+ G ++ L K G + I E+E
Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE 1082
Query: 102 VRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQA 161
+R QT+ Q A ++ +E S + T P +
Sbjct: 1083 LR---QTVKQLKEQLAKKE----------KEHASGSGAQSEAAGRTEP--------TGPK 1121
Query: 162 LEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVA 221
LE L + L L +L++E R + +++LQ ++ E Q+L +
Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181
Query: 222 ----------VAADRKK-DTMIEQLDKTLARVVEGWNRHEAERTEVL------------- 257
+AA R K + D+ A+V G R EAER L
Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARG--RQEAERKNSLISSLEEEVSILNR 1239
Query: 258 RGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET-LEEERQAL 316
+ L++E ++ EL R E+ Q L E + L E S + ER + L EE Q+L
Sbjct: 1240 QVLEKEGESKELKRLVMAES--EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297
Query: 317 TLRLEAEQQRCCV--LQEE--RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ---- 368
R EAE+QR L++E A RA +L + + + +E+ + Q EH
Sbjct: 1298 --REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355
Query: 369 -------LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGEL-- 419
K Q LQ E A +R +E+ ++ QAA + +L Q E+ GEL
Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL----GELIP 1411
Query: 420 ---DTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAAS 476
A +ER A QL +A Y Q L+ + E+ L + A+
Sbjct: 1412 LRQKVAEQERTAQQLRAE--KASYAEQLSMLKKAHGLLAEEN----------RGLGERAN 1459
Query: 477 L-REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535
L R+ +L ++ QELA+ A + +AE + Q A + E+ A+ + ++
Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519
Query: 536 QSGNQQLEEQRVEL---VERLQAMLQAHWDEANQL 567
Q+ +E+R +L VE+L+ + + +L
Sbjct: 1520 LEERQRFQEERQKLTAQVEQLEVFQREQTKQVEEL 1554
Score = 67.8 bits (164), Expect = 4e-11
Identities = 81/340 (23%), Positives = 149/340 (43%), Gaps = 57/340 (16%)
Query: 274 QQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEE 333
+++ + Q + + LN +Q ++ L+ +E E L ++ ++LT+RL ++C L+ E
Sbjct: 246 EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTE 305
Query: 334 RDA--ARAGQLSEHR-ELE-TLRAALEEERQTWAQQEHQLKEHYQALQE--ESQAQLERE 387
+ + QLSE +L LR +Q +EH +A QE E QAQLE+E
Sbjct: 306 KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365
Query: 388 -----------KEKSQREAQAAWETQHQLALVQSEVRRLEGE-------LDTARRERDAL 429
+EK++ + + L+ +Q + +GE L+T ++E L
Sbjct: 366 LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATL 425
Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE--------SSLRQAASLREHH 481
+ +QAR E LE+E Q + + ER +E + L+ + S
Sbjct: 426 AANNTQLQARVE----MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQA 481
Query: 482 RKQLQDLSGQHQQELASQLAQFKVEMA------------------EREERQQQVAEDYEL 523
+++L+ S H L +Q+A E+ + +E+Q Q+A+ +
Sbjct: 482 KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541
Query: 524 RLAREQA---RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
+ Q +V +L S +Q E+Q E+ E+ +A Q H
Sbjct: 542 QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH 581
Score = 65.5 bits (158), Expect = 2e-10
Identities = 135/581 (23%), Positives = 235/581 (40%), Gaps = 89/581 (15%)
Query: 39 YASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFE 98
++ L++SRQ A L + + AQ+L+ LS EK SK +
Sbjct: 862 HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT---SKEVAR 918
Query: 99 MESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSS 158
+E++ + +T+ ++P G +R+ E L + Q S ++
Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAG---DRQPE---------WLEEQQGRQFCSTQAA 966
Query: 159 AQALEELFPRYTSLRPGPPLNPPDFQGLRDAL----DSEHTRRKHCERHIQSLQTRVLEL 214
QA+E + + + + LR AL + R ER + L
Sbjct: 967 LQAMEREAEQMGN----------ELERLRAALMESQGQQQEERGQQEREVARLTQERGRA 1016
Query: 215 QQQLAVAVAAD-----RKKDTMIEQ------LDKTLARVVEGWNRHEAERTEVLRGLQEE 263
Q LA+ AA R ++ + EQ L + LA + + E + LRGL E
Sbjct: 1017 QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK-LRGL-EA 1074
Query: 264 HQAAELTRSKQQETVTRLEQSLS----EAMEALNREQESARLQQR---ERETLEEERQAL 316
Q EL +Q TV +L++ L+ E + E+A + + E L E L
Sbjct: 1075 AQIKELEELRQ--TVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132
Query: 317 TLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ---------TWAQQE- 366
+ + +Q++ L+ +A RA + LETL+ LEE+ Q AQ+E
Sbjct: 1133 EQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL 1192
Query: 367 ----HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTA 422
++++H +A ++E +AQ+ R +++++R+ + +++++ +V EGE
Sbjct: 1193 AAFRTKVQDHSKA-EDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251
Query: 423 RRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR-QAASLREHH 481
+R LV A E + E +Q E A + S+LR + SLRE
Sbjct: 1252 KR----------LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA 1301
Query: 482 RKQ-------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCE 534
KQ Q+L+ Q E A +L Q E+ +++Q +L QA V E
Sbjct: 1302 EKQRVASENLRQELTS--QAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSE 1359
Query: 535 LQSGN---QQLEEQRVELVERLQAMLQAHWDEANQLLSTTL 572
L QQL+ ++ +R + L+ A L + L
Sbjct: 1360 LLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400
Score = 46.2 bits (108), Expect = 1e-04
Identities = 47/186 (25%), Positives = 88/186 (47%), Gaps = 33/186 (17%)
Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE 468
Q ++RRL+ +L R RD L+LE++ E++++ E + + + Q+ +RLA E
Sbjct: 213 QFQMRRLKKQLADERSNRDELELELA------ENRKLLTEKDAQIAMMQQRIDRLALLNE 266
Query: 469 SSLRQAASLREHHRKQLQDLSGQHQ------QELASQLAQFKVEMAEREERQQQVAE--- 519
+QAAS E K+L++L +++ E Q K E ++ + + Q++E
Sbjct: 267 ---KQAASPLE--PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321
Query: 520 DYELRLAREQARVCELQSGNQQLEEQ-----------RVELVERLQAMLQAH--WDEANQ 566
D +L + + +LQ +L E+ + +L + L A LQ +E N+
Sbjct: 322 DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381
Query: 567 LLSTTL 572
+L L
Sbjct: 382 ILQGKL 387
Score = 45.8 bits (107), Expect = 2e-04
Identities = 57/278 (20%), Positives = 122/278 (43%), Gaps = 62/278 (22%)
Query: 201 ERHIQSL-------QTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253
E+++Q L +TR+ E+Q++ A + R+ + M + + +V+E R + ER
Sbjct: 1474 EKYVQELAAVRADAETRLAEVQRE---AQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530
Query: 254 TEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313
++ +++ E+ + +Q + V L + L+++ +A +Q+ + Q + ++E
Sbjct: 1531 QKLTAQVEQ----LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEA 1586
Query: 314 QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHY 373
Q L +L Q + L ++ AA EH +L+ +A K HY
Sbjct: 1587 QRLQAQLNELQAQ---LSQKEQAA------EHYKLQMEKA----------------KTHY 1621
Query: 374 QALQEESQ---------AQLEREKEKSQREAQAAWETQHQLAL-----------VQSEVR 413
A ++++Q QL++E ++ + EA+ Q L + ++VR
Sbjct: 1622 DAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVR 1681
Query: 414 RLEGEL---DTARRERDALQLEMSLVQARYESQRIQLE 448
LE ++ D R+ Q+ +++R + QL+
Sbjct: 1682 SLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 83.6 bits (205), Expect = 8e-16
Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%)
Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
T LL Q L+ S+ + LEE + L+D LD E +++
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1362
Query: 201 ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228
ERHI +L Q + L QQ AA ++ K
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 229 DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275
+ + ++LD L + +++ AE + +E AE +++
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321
L ++L EA+EA + + ++ + E E L E+ ++AL ++E
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 322 AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381
+ + L++E A +L ++ L+ E + Q +Q + + Q E +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 382 AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420
+LE E+++ A A E QL +Q++++ + EL+
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 421 TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472
AR RD A E E+ +QL+ +LA R E LA+ SSL
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
+L++ R+ L+ Q ++EL + + M++R + Q AE LA E++
Sbjct: 1723 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1780
Query: 533 CELQSGNQQLEEQRVELVERLQAM 556
+ +S QQLE Q EL +L M
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEM 1804
Score = 72.0 bits (175), Expect = 2e-12
Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251
R E + +T+ L L + L A+ A + + + L + +V G N HE
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 252 ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299
E+++ L L++E QA E + + + + L+ ++A + + E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 300 RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340
R Q + E ET LE+ER+ L A+++ L++ + D+A G
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 341 --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394
Q+ + RELE RA+ +E T + E + K LQE+ A K+ +
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 395 AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
+ A E L+ +Q E RRLE + E + Q M + S R++ ++
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1765
Query: 452 AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
A QL + TER AQ ES+ +Q + R +L ++ G + + S +A + ++A+
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
EE+ +Q A + +QA L+ +++L+E ++ VE + M + + ++A +
Sbjct: 1826 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1874
Score = 69.7 bits (169), Expect = 1e-11
Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%)
Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
+ Q LD E ++ + + I+ L+ + +LQ+ L AA K + L + L
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1148
Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
EA +TE+ L EL R+K+++ VT L+++L E E + E + +
Sbjct: 1149 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1197
Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
+Q+ + +EE + L E+ A+A + LE A L E +
Sbjct: 1198 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
Q + +++ + L+ AQ++ + K +A E ++ +Q+EV + G L+
Sbjct: 1243 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
A + L +++ + ++ + + L+ E +L V+ +L Q +E
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1344
Query: 482 RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R LQD + +Q L ++ +++++ +++ Q A E ++ E+++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 539 NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585
QQ EE+ + +E+ + LQ D+ QL+S A S
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 586 SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637
S E ++ E A++L L+++ EA++EL +L + DL
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Score = 68.6 bits (166), Expect = 3e-11
Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L+ E R + + + + ++L+L++QL AA +K QL+K A
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 976
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
EA+ ++ L++E + +K + LE+ +S+ L E+E A+ + +
Sbjct: 977 EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
E L +RL+ E++ L++ + H ++ L+A + E + A++E
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1089
Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429
EE QA L R ++ ++ A ++ ++ + L+ +LD+ R R+
Sbjct: 1090 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488
+ + + E+ + +LE L Q+ + + + L++A H Q+Q++
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 489 SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528
+H Q EL QL QFK A ++ +Q Q ++ E + +
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 529 QARVCELQSGNQQLEEQRVELVERLQAM 556
+A+V ELQS E R EL +++ +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKL 1285
Score = 67.0 bits (162), Expect = 7e-11
Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%)
Query: 272 SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331
++Q+E + E L + E + + + +++ L EE+ L +L+AE + +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 332 EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391
E R A + L + A LEEE Q + + K + +Q L+ E++
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 960
Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449
+ EA A + Q + ++++++LE E+ + + L E L++ R L E
Sbjct: 961 EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 450 ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501
E A L + + + E +R L + RK D S H+Q +L +Q+A
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 502 QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544
+ K+++A++EE Q + +A++ + + +LQ + + E+
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 545 QRVELVERLQAM 556
Q+ +L E L+A+
Sbjct: 1140 QKRDLGEELEAL 1151
Score = 66.2 bits (160), Expect = 1e-10
Identities = 111/537 (20%), Positives = 222/537 (41%), Gaps = 79/537 (14%)
Query: 36 SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92
S YA R +AEA + L E L+ +EL R+ L +E + KD
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1522
Query: 93 -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
K++ E+E + L+T ++ + E +E D+ L
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1565
Query: 152 DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211
+ QAL+ F R D Q RD + E +R+ +R + +T +
Sbjct: 1566 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1605
Query: 212 LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266
+ ++Q A+A AA +K + ++ L+ ++G R EA + ++ Q E +
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1663
Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
A +R + T E+ L + QE +R R+ + E++ L L +
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 327 CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377
LQ+E R AR QL E E +E + + + Q Q ++L Q
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 378 EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432
E ++ QLER+ ++ + E + A +++ + +A +++++ +LE +++ RE+ A
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 433 MSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQH 492
+ + + +Q+E E+++ E+ + E + L ++QL++ + +
Sbjct: 1844 LKQKDKKLKEILLQVED------ERKMAEQYKEQAEKGNARVKQL----KRQLEE-AEEE 1892
Query: 493 QQELASQLAQFKVEMAEREERQQQVAEDY-----ELRLAREQARVCELQSGNQQLEE 544
Q + + + + E+ E E + + + +LR E + V +SG +++ E
Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949
Score = 65.1 bits (157), Expect = 3e-10
Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%)
Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
T+ K VTR E+ + + L + +E + + E + LE++ LT
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 886
Query: 330 LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
EE++ L E + ET L A EE R A ++ +L+E + E +A+LE E+
Sbjct: 887 --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 935
Query: 389 EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448
++ Q + Q + + ++ LE +L+ R LQLE +A+ + +LE
Sbjct: 936 DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 984
Query: 449 SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
E+ V +Q +L + + S L + E K L L +H+ S +++ +
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1040
Query: 505 VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
V + ++EE+ +Q E + +L + + ++ +LQ+ +L+ Q + E LQA L
Sbjct: 1041 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 561 WDEANQ 566
DE Q
Sbjct: 1100 DDEIAQ 1105
Score = 60.1 bits (144), Expect = 9e-09
Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%)
Query: 255 EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304
E ++ ++E Q + + K + + LEQ S+ E N QE + +
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 305 ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354
+++ LEE + RLE E+ R LQ ER L +LE AA
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 355 -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400
LE+E Q ++L + + L+E + L E+EK++ + +
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1029
Query: 401 TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
+H+ + + EVR + EL+ +R+ + + A ++Q +L+ +LA +
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 456 EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500
E+ R+ + +AQ + ++L++ L H +DL + +++L +L
Sbjct: 1090 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148
Query: 501 AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560
K E+ E+ A ELR REQ E+ + L+E+ ++Q M Q H
Sbjct: 1149 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 561 WDEANQL 567
+L
Sbjct: 1202 AQAVEEL 1208
Score = 43.9 bits (102), Expect = 7e-04
Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%)
Query: 344 EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403
+ E++ L++ ++ + E++LKE E+ +QL EK Q + QA E
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 901
Query: 404 QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463
+ +E + L ++E + + EM E + QL++E +Q +
Sbjct: 902 ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 464 AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509
+E + RQ L E K+L+D + ++ L +++ +AE
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 510 REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
EE + + + + E+RL +E+ EL+ ++LE + E++ A LQA
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1076
Query: 560 HWDEANQLLS 569
E L+
Sbjct: 1077 QIAELKMQLA 1086
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 83.6 bits (205), Expect = 8e-16
Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%)
Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
T LL Q L+ S+ + LEE + L+D LD E +++
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1369
Query: 201 ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228
ERHI +L Q + L QQ AA ++ K
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 229 DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275
+ + ++LD L + +++ AE + +E AE +++
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321
L ++L EA+EA + + ++ + E E L E+ ++AL ++E
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 322 AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381
+ + L++E A +L ++ L+ E + Q +Q + + Q E +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 382 AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420
+LE E+++ A A E QL +Q++++ + EL+
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 421 TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472
AR RD A E E+ +QL+ +LA R E LA+ SSL
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
+L++ R+ L+ Q ++EL + + M++R + Q AE LA E++
Sbjct: 1730 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1787
Query: 533 CELQSGNQQLEEQRVELVERLQAM 556
+ +S QQLE Q EL +L M
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEM 1811
Score = 72.0 bits (175), Expect = 2e-12
Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251
R E + +T+ L L + L A+ A + + + L + +V G N HE
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 252 ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299
E+++ L L++E QA E + + + + L+ ++A + + E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 300 RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340
R Q + E ET LE+ER+ L A+++ L++ + D+A G
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 341 --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394
Q+ + RELE RA+ +E T + E + K LQE+ A K+ +
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 395 AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
+ A E L+ +Q E RRLE + E + Q M + S R++ ++
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1772
Query: 452 AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
A QL + TER AQ ES+ +Q + R +L ++ G + + S +A + ++A+
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
EE+ +Q A + +QA L+ +++L+E ++ VE + M + + ++A +
Sbjct: 1833 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1881
Score = 69.7 bits (169), Expect = 1e-11
Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%)
Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
+ Q LD E ++ + + I+ L+ + +LQ+ L AA K + L + L
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1155
Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
EA +TE+ L EL R+K+++ VT L+++L E E + E + +
Sbjct: 1156 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1204
Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
+Q+ + +EE + L E+ A+A + LE A L E +
Sbjct: 1205 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
Q + +++ + L+ AQ++ + K +A E ++ +Q+EV + G L+
Sbjct: 1250 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
A + L +++ + ++ + + L+ E +L V+ +L Q +E
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1351
Query: 482 RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R LQD + +Q L ++ +++++ +++ Q A E ++ E+++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 539 NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585
QQ EE+ + +E+ + LQ D+ QL+S A S
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 586 SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637
S E ++ E A++L L+++ EA++EL +L + DL
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Score = 68.6 bits (166), Expect = 3e-11
Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L+ E R + + + + ++L+L++QL AA +K QL+K A
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 983
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
EA+ ++ L++E + +K + LE+ +S+ L E+E A+ + +
Sbjct: 984 EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
E L +RL+ E++ L++ + H ++ L+A + E + A++E
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1096
Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429
EE QA L R ++ ++ A ++ ++ + L+ +LD+ R R+
Sbjct: 1097 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488
+ + + E+ + +LE L Q+ + + + L++A H Q+Q++
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 489 SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528
+H Q EL QL QFK A ++ +Q Q ++ E + +
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 529 QARVCELQSGNQQLEEQRVELVERLQAM 556
+A+V ELQS E R EL +++ +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKL 1292
Score = 67.0 bits (162), Expect = 7e-11
Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%)
Query: 272 SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331
++Q+E + E L + E + + + +++ L EE+ L +L+AE + +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 332 EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391
E R A + L + A LEEE Q + + K + +Q L+ E++
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 967
Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449
+ EA A + Q + ++++++LE E+ + + L E L++ R L E
Sbjct: 968 EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 450 ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501
E A L + + + E +R L + RK D S H+Q +L +Q+A
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 502 QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544
+ K+++A++EE Q + +A++ + + +LQ + + E+
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 545 QRVELVERLQAM 556
Q+ +L E L+A+
Sbjct: 1147 QKRDLGEELEAL 1158
Score = 66.2 bits (160), Expect = 1e-10
Identities = 111/537 (20%), Positives = 222/537 (41%), Gaps = 79/537 (14%)
Query: 36 SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92
S YA R +AEA + L E L+ +EL R+ L +E + KD
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1529
Query: 93 -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
K++ E+E + L+T ++ + E +E D+ L
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1572
Query: 152 DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211
+ QAL+ F R D Q RD + E +R+ +R + +T +
Sbjct: 1573 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1612
Query: 212 LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266
+ ++Q A+A AA +K + ++ L+ ++G R EA + ++ Q E +
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1670
Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
A +R + T E+ L + QE +R R+ + E++ L L +
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 327 CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377
LQ+E R AR QL E E +E + + + Q Q ++L Q
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 378 EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432
E ++ QLER+ ++ + E + A +++ + +A +++++ +LE +++ RE+ A
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 433 MSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQH 492
+ + + +Q+E E+++ E+ + E + L ++QL++ + +
Sbjct: 1851 LKQKDKKLKEILLQVED------ERKMAEQYKEQAEKGNARVKQL----KRQLEE-AEEE 1899
Query: 493 QQELASQLAQFKVEMAEREERQQQVAEDY-----ELRLAREQARVCELQSGNQQLEE 544
Q + + + + E+ E E + + + +LR E + V +SG +++ E
Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956
Score = 65.1 bits (157), Expect = 3e-10
Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%)
Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
T+ K VTR E+ + + L + +E + + E + LE++ LT
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 893
Query: 330 LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
EE++ L E + ET L A EE R A ++ +L+E + E +A+LE E+
Sbjct: 894 --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 942
Query: 389 EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448
++ Q + Q + + ++ LE +L+ R LQLE +A+ + +LE
Sbjct: 943 DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 991
Query: 449 SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
E+ V +Q +L + + S L + E K L L +H+ S +++ +
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1047
Query: 505 VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
V + ++EE+ +Q E + +L + + ++ +LQ+ +L+ Q + E LQA L
Sbjct: 1048 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 561 WDEANQ 566
DE Q
Sbjct: 1107 DDEIAQ 1112
Score = 60.1 bits (144), Expect = 9e-09
Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%)
Query: 255 EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304
E ++ ++E Q + + K + + LEQ S+ E N QE + +
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 305 ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354
+++ LEE + RLE E+ R LQ ER L +LE AA
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 355 -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400
LE+E Q ++L + + L+E + L E+EK++ + +
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1036
Query: 401 TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
+H+ + + EVR + EL+ +R+ + + A ++Q +L+ +LA +
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 456 EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500
E+ R+ + +AQ + ++L++ L H +DL + +++L +L
Sbjct: 1097 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155
Query: 501 AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560
K E+ E+ A ELR REQ E+ + L+E+ ++Q M Q H
Sbjct: 1156 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 561 WDEANQL 567
+L
Sbjct: 1209 AQAVEEL 1215
Score = 43.9 bits (102), Expect = 7e-04
Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%)
Query: 344 EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403
+ E++ L++ ++ + E++LKE E+ +QL EK Q + QA E
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 908
Query: 404 QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463
+ +E + L ++E + + EM E + QL++E +Q +
Sbjct: 909 ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 464 AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509
+E + RQ L E K+L+D + ++ L +++ +AE
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 510 REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
EE + + + + E+RL +E+ EL+ ++LE + E++ A LQA
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1083
Query: 560 HWDEANQLLS 569
E L+
Sbjct: 1084 QIAELKMQLA 1093
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 83.6 bits (205), Expect = 8e-16
Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%)
Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
T LL Q L+ S+ + LEE + L+D LD E +++
Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1369
Query: 201 ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228
ERHI +L Q + L QQ AA ++ K
Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429
Query: 229 DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275
+ + ++LD L + +++ AE + +E AE +++
Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489
Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321
L ++L EA+EA + + ++ + E E L E+ ++AL ++E
Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549
Query: 322 AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381
+ + L++E A +L ++ L+ E + Q +Q + + Q E +
Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 382 AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420
+LE E+++ A A E QL +Q++++ + EL+
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669
Query: 421 TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472
AR RD A E E+ +QL+ +LA R E LA+ SSL
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729
Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
+L++ R+ L+ Q ++EL + + M++R + Q AE LA E++
Sbjct: 1730 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1787
Query: 533 CELQSGNQQLEEQRVELVERLQAM 556
+ +S QQLE Q EL +L M
Sbjct: 1788 QKNESARQQLERQNKELRSKLHEM 1811
Score = 72.0 bits (175), Expect = 2e-12
Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251
R E + +T+ L L + L A+ A + + + L + +V G N HE
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537
Query: 252 ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299
E+++ L L++E QA E + + + + L+ ++A + + E
Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597
Query: 300 RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340
R Q + E ET LE+ER+ L A+++ L++ + D+A G
Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657
Query: 341 --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394
Q+ + RELE RA+ +E T + E + K LQE+ A K+ +
Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717
Query: 395 AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
+ A E L+ +Q E RRLE + E + Q M + S R++ ++
Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1772
Query: 452 AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
A QL + TER AQ ES+ +Q + R +L ++ G + + S +A + ++A+
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832
Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
EE+ +Q A + +QA L+ +++L+E ++ VE + M + + ++A +
Sbjct: 1833 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1881
Score = 70.1 bits (170), Expect = 9e-12
Identities = 82/391 (20%), Positives = 163/391 (41%), Gaps = 61/391 (15%)
Query: 77 RSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTML---QTSRDTAYRDPLIPGAGSERREE 133
++L E++L+ +D E R QLQ L +T + + + A ++ E
Sbjct: 1577 QALKGQFERDLQARDEQN-----EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631
Query: 134 DSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSE 193
D D + L S+ + EE + L+ + + R + D
Sbjct: 1632 DLKDLE-------------LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Query: 194 HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253
K E+ +SL+ +++LQ+ LA A A ++ D E+L + LA + G N + E+
Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738
Query: 254 TEV---LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLE 310
+ + L+EE + + + V + Q + L E+ +A+ + R+ LE
Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798
Query: 311 EERQALTLRLE---------------AEQQRCCVLQE-------ERDAARAGQLSEHREL 348
+ + L +L A + + L+E E+ AA + ++L
Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858
Query: 349 ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408
+ + +E+ER+ A+Q + E A ++ + QLE +E+SQR +
Sbjct: 1859 KEILLQVEDERKM-AEQYKEQAEKGNARVKQLKRQLEEAEEESQR--------------I 1903
Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQAR 439
+ R+L+ ELD A +A+ E++ ++++
Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 69.7 bits (169), Expect = 1e-11
Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%)
Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
+ Q LD E ++ + + I+ L+ + +LQ+ L AA K + L + L
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1155
Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
EA +TE+ L EL R+K+++ VT L+++L E E + E + +
Sbjct: 1156 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1204
Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
+Q+ + +EE + L E+ A+A + LE A L E +
Sbjct: 1205 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1249
Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
Q + +++ + L+ AQ++ + K +A E ++ +Q+EV + G L+
Sbjct: 1250 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305
Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
A + L +++ + ++ + + L+ E +L V+ +L Q +E
Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1351
Query: 482 RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R LQD + +Q L ++ +++++ +++ Q A E ++ E+++
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411
Query: 539 NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585
QQ EE+ + +E+ + LQ D+ QL+S A S
Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471
Query: 586 SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637
S E ++ E A++L L+++ EA++EL +L + DL
Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523
Score = 68.6 bits (166), Expect = 3e-11
Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L+ E R + + + + ++L+L++QL AA +K QL+K A
Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 983
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
EA+ ++ L++E + +K + LE+ +S+ L E+E A+ + +
Sbjct: 984 EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
E L +RL+ E++ L++ + H ++ L+A + E + A++E
Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1096
Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429
EE QA L R ++ ++ A ++ ++ + L+ +LD+ R R+
Sbjct: 1097 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1144
Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488
+ + + E+ + +LE L Q+ + + + L++A H Q+Q++
Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204
Query: 489 SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528
+H Q EL QL QFK A ++ +Q Q ++ E + +
Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264
Query: 529 QARVCELQSGNQQLEEQRVELVERLQAM 556
+A+V ELQS E R EL +++ +
Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKL 1292
Score = 67.0 bits (162), Expect = 7e-11
Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%)
Query: 272 SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331
++Q+E + E L + E + + + +++ L EE+ L +L+AE + +
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 332 EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391
E R A + L + A LEEE Q + + K + +Q L+ E++
Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 967
Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449
+ EA A + Q + ++++++LE E+ + + L E L++ R L E
Sbjct: 968 EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026
Query: 450 ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501
E A L + + + E +R L + RK D S H+Q +L +Q+A
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086
Query: 502 QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544
+ K+++A++EE Q + +A++ + + +LQ + + E+
Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146
Query: 545 QRVELVERLQAM 556
Q+ +L E L+A+
Sbjct: 1147 QKRDLGEELEAL 1158
Score = 65.1 bits (157), Expect = 3e-10
Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%)
Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
T+ K VTR E+ + + L + +E + + E + LE++ LT
Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 893
Query: 330 LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
EE++ L E + ET L A EE R A ++ +L+E + E +A+LE E+
Sbjct: 894 --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 942
Query: 389 EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448
++ Q + Q + + ++ LE +L+ R LQLE +A+ + +LE
Sbjct: 943 DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 991
Query: 449 SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
E+ V +Q +L + + S L + E K L L +H+ S +++ +
Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1047
Query: 505 VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
V + ++EE+ +Q E + +L + + ++ +LQ+ +L+ Q + E LQA L
Sbjct: 1048 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106
Query: 561 WDEANQ 566
DE Q
Sbjct: 1107 DDEIAQ 1112
Score = 64.7 bits (156), Expect = 4e-10
Identities = 105/483 (21%), Positives = 201/483 (41%), Gaps = 75/483 (15%)
Query: 36 SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92
S YA R +AEA + L E L+ +EL R+ L +E + KD
Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1529
Query: 93 -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
K++ E+E + L+T ++ + E +E D+ L
Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1572
Query: 152 DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211
+ QAL+ F R D Q RD + E +R+ +R + +T +
Sbjct: 1573 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1612
Query: 212 LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266
+ ++Q A+A AA +K + ++ L+ ++G R EA + ++ Q E +
Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1670
Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
A +R + T E+ L + QE +R R+ + E++ L L +
Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730
Query: 327 CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377
LQ+E R AR QL E E +E + + + Q Q ++L Q
Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790
Query: 378 EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432
E ++ QLER+ ++ + E + A +++ + +A +++++ +LE +++ RE+ A
Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850
Query: 433 MSLVQARYESQRIQLESE--LAVQLEQ----------RVTERLAQAQESSLRQAASLREH 480
+ + + +Q+E E +A Q ++ ++ +L +A+E S R A+ R+
Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910
Query: 481 HRK 483
R+
Sbjct: 1911 QRE 1913
Score = 60.1 bits (144), Expect = 9e-09
Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%)
Query: 255 EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304
E ++ ++E Q + + K + + LEQ S+ E N QE + +
Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918
Query: 305 ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354
+++ LEE + RLE E+ R LQ ER L +LE AA
Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978
Query: 355 -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400
LE+E Q ++L + + L+E + L E+EK++ + +
Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1036
Query: 401 TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
+H+ + + EVR + EL+ +R+ + + A ++Q +L+ +LA +
Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096
Query: 456 EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500
E+ R+ + +AQ + ++L++ L H +DL + +++L +L
Sbjct: 1097 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155
Query: 501 AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560
K E+ E+ A ELR REQ E+ + L+E+ ++Q M Q H
Sbjct: 1156 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1208
Query: 561 WDEANQL 567
+L
Sbjct: 1209 AQAVEEL 1215
Score = 43.9 bits (102), Expect = 7e-04
Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%)
Query: 344 EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403
+ E++ L++ ++ + E++LKE E+ +QL EK Q + QA E
Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 908
Query: 404 QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463
+ +E + L ++E + + EM E + QL++E +Q +
Sbjct: 909 ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964
Query: 464 AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509
+E + RQ L E K+L+D + ++ L +++ +AE
Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024
Query: 510 REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
EE + + + + E+RL +E+ EL+ ++LE + E++ A LQA
Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1083
Query: 560 HWDEANQLLS 569
E L+
Sbjct: 1084 QIAELKMQLA 1093
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 83.6 bits (205), Expect = 8e-16
Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%)
Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200
T LL Q L+ S+ + LEE + L+D LD E +++
Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1362
Query: 201 ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228
ERHI +L Q + L QQ AA ++ K
Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422
Query: 229 DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275
+ + ++LD L + +++ AE + +E AE +++
Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482
Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321
L ++L EA+EA + + ++ + E E L E+ ++AL ++E
Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542
Query: 322 AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381
+ + L++E A +L ++ L+ E + Q +Q + + Q E +
Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 382 AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420
+LE E+++ A A E QL +Q++++ + EL+
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662
Query: 421 TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472
AR RD A E E+ +QL+ +LA R E LA+ SSL
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722
Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532
+L++ R+ L+ Q ++EL + + M++R + Q AE LA E++
Sbjct: 1723 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1780
Query: 533 CELQSGNQQLEEQRVELVERLQAM 556
+ +S QQLE Q EL +L M
Sbjct: 1781 QKNESARQQLERQNKELRSKLHEM 1804
Score = 72.0 bits (175), Expect = 2e-12
Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%)
Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251
R E + +T+ L L + L A+ A + + + L + +V G N HE
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530
Query: 252 ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299
E+++ L L++E QA E + + + + L+ ++A + + E
Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590
Query: 300 RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340
R Q + E ET LE+ER+ L A+++ L++ + D+A G
Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650
Query: 341 --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394
Q+ + RELE RA+ +E T + E + K LQE+ A K+ +
Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710
Query: 395 AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
+ A E L+ +Q E RRLE + E + Q M + S R++ ++
Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1765
Query: 452 AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509
A QL + TER AQ ES+ +Q + R +L ++ G + + S +A + ++A+
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825
Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566
EE+ +Q A + +QA L+ +++L+E ++ VE + M + + ++A +
Sbjct: 1826 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1874
Score = 70.1 bits (170), Expect = 9e-12
Identities = 82/391 (20%), Positives = 163/391 (41%), Gaps = 61/391 (15%)
Query: 77 RSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTML---QTSRDTAYRDPLIPGAGSERREE 133
++L E++L+ +D E R QLQ L +T + + + A ++ E
Sbjct: 1570 QALKGQFERDLQARDEQN-----EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624
Query: 134 DSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSE 193
D D + L S+ + EE + L+ + + R + D
Sbjct: 1625 DLKDLE-------------LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Query: 194 HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253
K E+ +SL+ +++LQ+ LA A A ++ D E+L + LA + G N + E+
Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731
Query: 254 TEV---LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLE 310
+ + L+EE + + + V + Q + L E+ +A+ + R+ LE
Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791
Query: 311 EERQALTLRLE---------------AEQQRCCVLQE-------ERDAARAGQLSEHREL 348
+ + L +L A + + L+E E+ AA + ++L
Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851
Query: 349 ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408
+ + +E+ER+ A+Q + E A ++ + QLE +E+SQR +
Sbjct: 1852 KEILLQVEDERKM-AEQYKEQAEKGNARVKQLKRQLEEAEEESQR--------------I 1896
Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQAR 439
+ R+L+ ELD A +A+ E++ ++++
Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSK 1927
Score = 69.7 bits (169), Expect = 1e-11
Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%)
Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
+ Q LD E ++ + + I+ L+ + +LQ+ L AA K + L + L
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1148
Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
EA +TE+ L EL R+K+++ VT L+++L E E + E + +
Sbjct: 1149 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1197
Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361
+Q+ + +EE + L E+ A+A + LE A L E +
Sbjct: 1198 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1242
Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421
Q + +++ + L+ AQ++ + K +A E ++ +Q+EV + G L+
Sbjct: 1243 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298
Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481
A + L +++ + ++ + + L+ E +L V+ +L Q +E
Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1344
Query: 482 RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538
R LQD + +Q L ++ +++++ +++ Q A E ++ E+++
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404
Query: 539 NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585
QQ EE+ + +E+ + LQ D+ QL+S A S
Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464
Query: 586 SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637
S E ++ E A++L L+++ EA++EL +L + DL
Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516
Score = 68.6 bits (166), Expect = 3e-11
Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249
L+ E R + + + + ++L+L++QL AA +K QL+K A
Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 976
Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309
EA+ ++ L++E + +K + LE+ +S+ L E+E A+ + +
Sbjct: 977 EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369
E L +RL+ E++ L++ + H ++ L+A + E + A++E
Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1089
Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429
EE QA L R ++ ++ A ++ ++ + L+ +LD+ R R+
Sbjct: 1090 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1137
Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488
+ + + E+ + +LE L Q+ + + + L++A H Q+Q++
Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197
Query: 489 SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528
+H Q EL QL QFK A ++ +Q Q ++ E + +
Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257
Query: 529 QARVCELQSGNQQLEEQRVELVERLQAM 556
+A+V ELQS E R EL +++ +
Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKL 1285
Score = 67.0 bits (162), Expect = 7e-11
Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%)
Query: 272 SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331
++Q+E + E L + E + + + +++ L EE+ L +L+AE + +
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 332 EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391
E R A + L + A LEEE Q + + K + +Q L+ E++
Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 960
Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449
+ EA A + Q + ++++++LE E+ + + L E L++ R L E
Sbjct: 961 EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019
Query: 450 ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501
E A L + + + E +R L + RK D S H+Q +L +Q+A
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079
Query: 502 QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544
+ K+++A++EE Q + +A++ + + +LQ + + E+
Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139
Query: 545 QRVELVERLQAM 556
Q+ +L E L+A+
Sbjct: 1140 QKRDLGEELEAL 1151
Score = 65.1 bits (157), Expect = 3e-10
Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%)
Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
T+ K VTR E+ + + L + +E + + E + LE++ LT
Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 886
Query: 330 LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
EE++ L E + ET L A EE R A ++ +L+E + E +A+LE E+
Sbjct: 887 --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 935
Query: 389 EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448
++ Q + Q + + ++ LE +L+ R LQLE +A+ + +LE
Sbjct: 936 DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 984
Query: 449 SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504
E+ V +Q +L + + S L + E K L L +H+ S +++ +
Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1040
Query: 505 VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560
V + ++EE+ +Q E + +L + + ++ +LQ+ +L+ Q + E LQA L
Sbjct: 1041 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099
Query: 561 WDEANQ 566
DE Q
Sbjct: 1100 DDEIAQ 1105
Score = 64.7 bits (156), Expect = 4e-10
Identities = 105/483 (21%), Positives = 201/483 (41%), Gaps = 75/483 (15%)
Query: 36 SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92
S YA R +AEA + L E L+ +EL R+ L +E + KD
Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1522
Query: 93 -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
K++ E+E + L+T ++ + E +E D+ L
Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1565
Query: 152 DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211
+ QAL+ F R D Q RD + E +R+ +R + +T +
Sbjct: 1566 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1605
Query: 212 LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266
+ ++Q A+A AA +K + ++ L+ ++G R EA + ++ Q E +
Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1663
Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326
A +R + T E+ L + QE +R R+ + E++ L L +
Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723
Query: 327 CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377
LQ+E R AR QL E E +E + + + Q Q ++L Q
Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783
Query: 378 EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432
E ++ QLER+ ++ + E + A +++ + +A +++++ +LE +++ RE+ A
Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843
Query: 433 MSLVQARYESQRIQLESE--LAVQLEQ----------RVTERLAQAQESSLRQAASLREH 480
+ + + +Q+E E +A Q ++ ++ +L +A+E S R A+ R+
Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903
Query: 481 HRK 483
R+
Sbjct: 1904 QRE 1906
Score = 60.1 bits (144), Expect = 9e-09
Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%)
Query: 255 EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304
E ++ ++E Q + + K + + LEQ S+ E N QE + +
Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911
Query: 305 ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354
+++ LEE + RLE E+ R LQ ER L +LE AA
Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971
Query: 355 -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400
LE+E Q ++L + + L+E + L E+EK++ + +
Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1029
Query: 401 TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455
+H+ + + EVR + EL+ +R+ + + A ++Q +L+ +LA +
Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089
Query: 456 EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500
E+ R+ + +AQ + ++L++ L H +DL + +++L +L
Sbjct: 1090 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148
Query: 501 AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560
K E+ E+ A ELR REQ E+ + L+E+ ++Q M Q H
Sbjct: 1149 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1201
Query: 561 WDEANQL 567
+L
Sbjct: 1202 AQAVEEL 1208
Score = 43.9 bits (102), Expect = 7e-04
Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%)
Query: 344 EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403
+ E++ L++ ++ + E++LKE E+ +QL EK Q + QA E
Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 901
Query: 404 QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463
+ +E + L ++E + + EM E + QL++E +Q +
Sbjct: 902 ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957
Query: 464 AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509
+E + RQ L E K+L+D + ++ L +++ +AE
Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017
Query: 510 REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559
EE + + + + E+RL +E+ EL+ ++LE + E++ A LQA
Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1076
Query: 560 HWDEANQLLS 569
E L+
Sbjct: 1077 QIAELKMQLA 1086
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 82.8 bits (203), Expect = 1e-15
Identities = 93/404 (23%), Positives = 184/404 (45%), Gaps = 38/404 (9%)
Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246
RDAL E R + L+ + ELQ++L +A + + +++L + L R
Sbjct: 168 RDALSLELYRNTITN---EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLL 224
Query: 247 NRHEAERTEVLRGLQEEH-QAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRE 305
+ + + QEE + E KQ+E + R E+ L E E REQE +++++E
Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE-QEGKMREQEE-KMRRQE 282
Query: 306 RETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQ- 364
+ E+E++ E +Q+ QEE+ + ++ E E E+E + W Q
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE-----KMREQEEKMWRQE 337
Query: 365 -----QEHQLKEHYQALQEESQAQLE-----REKEKSQREAQAAWETQHQL---ALVQSE 411
QE Q++E Q ++++ + E REKE+ RE + WE + ++ ++
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397
Query: 412 VRRLEGELDTARRERDALQL--EMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQES 469
+++ E +T R + + +Q E Q E Q+ +L + EQ E++ + +E
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ---EKMQEQEEK 454
Query: 470 SLRQAASLREHHRKQLQDLSGQHQQELASQLAQF---KVEMAEREER---QQQVAEDYEL 523
Q +R+ Q+ Q+++ Q Q + +M ++E++ Q++ + +
Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514
Query: 524 RLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567
RL ++ R+ E + QQ E+ R E ++ Q + WD+ ++
Sbjct: 515 RLREKEERMREQKKMWQQEEKMREE--KKTQEQEKKTWDQEEKM 556
Score = 77.4 bits (189), Expect = 6e-14
Identities = 77/406 (18%), Positives = 182/406 (44%), Gaps = 45/406 (11%)
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADR---KKDTMIEQLDKTLARV 242
+R+ + + K + L+ + EL++Q + ++ +++ M EQ +K +
Sbjct: 271 MREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQE 330
Query: 243 VEGWNRHEA--ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNRE---QE 297
+ W + E E+ + +R +++ + E +Q E + E+ + E + +E QE
Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390
Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALE 356
R+++RE++ EEE + ++Q + ++E + +L E +E L E
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 450
Query: 357 EERQTWAQQE----------HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLA 406
+E + W Q+E + K Q E + Q+ ++EK + + Q W+ + ++
Sbjct: 451 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM- 509
Query: 407 LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQA 466
E D RE++ + R + + Q E ++ + + + E+
Sbjct: 510 ----------WEQDERLREKEE--------RMREQKKMWQQEEKMREEKKTQEQEKKTWD 551
Query: 467 QESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER---QQQVAEDYEL 523
QE +R+ +RE +K ++ +QE ++ + + +M E+EE+ Q++ ++ E
Sbjct: 552 QEEKMREEERMREREKKMREEEEMMREQE--EKMQEQEEKMREQEEKMWEQEEKMQEQEE 609
Query: 524 RLAREQARVCELQSGN--QQLEEQRVELVERLQAMLQAHWDEANQL 567
++ ++ ++ E + + Q+ EE E E++Q + W++ ++
Sbjct: 610 KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM 655
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/386 (16%), Positives = 170/386 (44%), Gaps = 30/386 (7%)
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEA-ERTEVLRG 259
E + + ++ E +Q++ ++D + + ++ + + W + E + E +R
Sbjct: 337 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRE 396
Query: 260 LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLR 319
+++ + E T +Q+E + + E+++ E E +E + RL +++ + E+E+
Sbjct: 397 REKKMREEEETMREQEEKMQKQEENMWEQEE---KEWQQQRLPEQKEKLWEQEKMQ---- 449
Query: 320 LEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379
EQ+ QEE+ + + +++ E+E Q W +QE ++++ Q + ++
Sbjct: 450 ---EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW-EQEEKMRDQEQKMWDQ 505
Query: 380 SQAQLE-----REKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMS 434
+ E REKE+ RE + W+ + ++ + + + D + R+ ++
Sbjct: 506 EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565
Query: 435 LVQARYESQRIQLESELAVQLEQRVTE---RLAQAQESSLRQAASLREHHRKQLQDLSGQ 491
+ R E + ++ + E + E+++ E ++ + +E Q + E K +
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625
Query: 492 HQQELASQLAQFKVEMAERE----------ERQQQVAEDYELRLAREQARVCELQSGNQQ 541
QE + + + +M E+E Q++ + E ++ ++ ++ E + Q
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685
Query: 542 LEEQRVELVERLQAMLQAHWDEANQL 567
EE+ E E+++ + W + ++
Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKM 711
Score = 61.6 bits (148), Expect = 3e-09
Identities = 68/311 (21%), Positives = 135/311 (43%), Gaps = 46/311 (14%)
Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA--ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQS 284
++D M EQ +K + + W++ E E+ E LR ++E + E + QQE R E+
Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR--EKEERMREQKKMWQQEEKMREEKK 541
Query: 285 LSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSE 344
E + ++E R ++R RE ++ R+ + E E++ +QE+ + R
Sbjct: 542 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK----MQEQEEKMR------ 591
Query: 345 HRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQ 404
E E+E + Q+E ++ + ++E E++K Q + + WE + +
Sbjct: 592 ----EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE-------EEDKMQEQEEMMWEQEEK 640
Query: 405 LALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLA 464
+ Q + ++ + + R + + ++ + +Q + E R Q E
Sbjct: 641 M---QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ--------------EEKM 683
Query: 465 QAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQF-KVEMAEREERQQQVAEDYEL 523
Q QE +R+ E R Q + + GQ ++ + + + EM E+EER + E +
Sbjct: 684 QGQEEKMREQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Query: 524 RLAREQARVCE 534
RL + R E
Sbjct: 741 RLPEHEERCSE 751
Score = 61.2 bits (147), Expect = 4e-09
Identities = 67/393 (17%), Positives = 179/393 (45%), Gaps = 26/393 (6%)
Query: 188 DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARV-VEGW 246
+ L + + + E+ ++ + R+ E ++L R+++ M EQ +K +
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397
Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306
+ E E +R +E+ Q E +Q+E + +Q L E E L +++ Q +
Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKLWEQEK----MQEQE 452
Query: 307 ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHREL--ETLRAALEEERQTWAQ 364
E + E+ + + + E Q + ++E+ + Q+ E E + + ++E + W Q
Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512
Query: 365 QEHQLKEHYQALQEES----QAQLEREKEKSQREAQAAWETQHQLA---LVQSEVRRLEG 417
E +L+E + ++E+ Q + RE++K+Q + + W+ + ++ ++ +++
Sbjct: 513 DE-RLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 571
Query: 418 ELDTARRERDALQLEMSLVQARYES-----QRIQLESELAVQLEQRVTERLAQAQESSLR 472
E + R + + +Q + ++ + E +++Q + E + E+++ E Q +E ++
Sbjct: 572 EEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE---QEEEDKMQ 628
Query: 473 QAASLREHHRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQA 530
+ + +++Q+ + Q+E + + E E+ + Q++ + E ++ ++
Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE 688
Query: 531 RVCELQSGNQQLEEQRVELVERLQAMLQAHWDE 563
++ E + + EE+ E++ + W +
Sbjct: 689 KMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 721
Score = 56.6 bits (135), Expect = 1e-07
Identities = 84/398 (21%), Positives = 170/398 (42%), Gaps = 44/398 (11%)
Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRK-KDTMIEQLDKTLARVVEG 245
++AL E + H R + +T EL+ L + A RK +D + + R+
Sbjct: 80 QEALRREIEAQDHTIRILTCQKT---ELETALYYSQDAARKFEDGNLGESKDLAGRLHHS 136
Query: 246 WNRHEAERTEVLRGLQEEHQAA-----ELTRSKQQETVTRLEQSLS-EAMEALNRE-QES 298
W+ E L + H+ A ELT+ + ++ +++ E ++ N E QE
Sbjct: 137 WH-FAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEK 195
Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358
RL + E+ ++ + L +LE + + + Q + + + + EL + ++
Sbjct: 196 LRLAESEKSEIQLNVKELKRKLE--RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 253
Query: 359 RQTWAQQEHQLKEHYQALQEES-----QAQLEREKEKSQREAQAAWETQHQL-----ALV 408
+ +QE +L+E ++E+ Q + RE+EK RE + Q +L +
Sbjct: 254 EEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQ 313
Query: 409 QSEVRRLEGELDTARRERDALQLEMSL----VQARYESQRIQLESELAVQLEQRVTERLA 464
+ E + E E +E + E L Q R + Q+++ + E + ++R+ E+
Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE 373
Query: 465 Q--------AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQ 516
+ QE +++ +RE +K ++ +QE Q + + E +E QQQ
Sbjct: 374 RMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433
Query: 517 VAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
RL ++ ++ E Q Q+ EE+ E E+++
Sbjct: 434 -------RLPEQKEKLWE-QEKMQEQEEKIWEQEEKIR 463
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 82.4 bits (202), Expect = 2e-15
Identities = 112/553 (20%), Positives = 241/553 (43%), Gaps = 51/553 (9%)
Query: 32 SEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKD 91
+E+ LY S +Q E AR + S H+ FA EL ++LS + KK
Sbjct: 140 TELQMALYYSQHAVKQLEGEARDLI-----SRLHDSWK-FAGELEQALSAVATQ---KKK 190
Query: 92 GSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151
++I E+ R L L+ R+T + L + + +S+ + LN + L+
Sbjct: 191 ADRYIEELTKERDALS--LELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 248
Query: 152 D-------LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRK-HCERH 203
L P QA + + + L + L+ + + E
Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308
Query: 204 IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEG-WNRHEAERT--EVLRGL 260
IQ + ++ E ++++ R+++ I + ++ + R E W + E R E++
Sbjct: 309 IQEWEEKIQEQEEKI-------REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 361
Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320
+E+ + E +++E + LE+ + E + REQE R Q+ E+ +E+RQ ++
Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKI--REQEEKR-QEEEKIREQEKRQEQEAKM 418
Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRELETL--RAALEEERQTWAQQEHQLKEHYQALQE 378
++++ ++E+ + R + R+ E + + + EE + Q+E +E QE
Sbjct: 419 WRQEEK---IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 475
Query: 379 ESQAQLER--EKEKSQREAQAAWETQHQLALVQSEVRRLEGEL-----------DTARRE 425
E Q E+ E+EK +++ + W + ++ + ++R E ++ + R +
Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ 535
Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK-Q 484
+ ++ + ++Q + E Q E + +R E++ + +E Q +RE K
Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW 595
Query: 485 LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544
Q+ + Q+E+ + + E E+ Q++ ++ E ++ R++ ++ E + +Q EE
Sbjct: 596 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 655
Query: 545 QRVELVERLQAML 557
+ E E L+A +
Sbjct: 656 KMQEHQEHLEAAI 668
Score = 74.3 bits (181), Expect = 5e-13
Identities = 75/405 (18%), Positives = 179/405 (44%), Gaps = 31/405 (7%)
Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV-- 243
L++ L + + + +++ L+ R LE + L + D + ++L A++
Sbjct: 226 LQEKLQLVESEKSEIQLNVKELK-RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284
Query: 244 ----EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQE-- 297
E WNR ++ E + +E+ Q E +Q+E + E+ + E E + R++E
Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344
Query: 298 -SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE 356
+ R +E + E++ RLE ++ E+ + R + H E E +R E
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEE------MMWEKEEKIRELEEKMH-EQEKIREQEE 397
Query: 357 EERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQ---HQLALVQSEVR 413
+ ++ +E + ++ +A + ++ ++EK + + + W + H+ ++ E +
Sbjct: 398 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 457
Query: 414 RLEGELDTARRERDALQLEMSLVQAR-YESQRIQLESELAVQLEQRV----------TER 462
R E E + E+ Q E+ + + +E ++I+ + E + E+++ E+
Sbjct: 458 RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEK 517
Query: 463 LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522
+ + +E Q +RE K + +QE + K++ E+ RQ++ + E
Sbjct: 518 MWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577
Query: 523 LRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567
++ ++ ++ E + + EE+ E E +Q + W++ ++
Sbjct: 578 EKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 82.4 bits (202), Expect = 2e-15
Identities = 96/398 (24%), Positives = 176/398 (44%), Gaps = 45/398 (11%)
Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR---GLQEEHQAAEL 269
ELQ+ L+ +K D IE+L K + R+ E+ + LQE+ AE
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239
Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329
+S+ Q V L++ L A L + Q + ++ R+ E Q +R + E+
Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM---W 296
Query: 330 LQEERDAARAGQLSEHRE-LETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388
QEER + G++ E E + L E+ + +QE +L+E + ++E Q Q + EK
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
Query: 389 ------------EKSQREAQAAWETQHQLALVQSEVRRLE---GELDTARRERDALQLEM 433
EK R+ + WE + Q+ + ++R E E D RE++ E
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416
Query: 434 SLVQARYESQRIQ----------LESELAVQLEQRVTER--LAQAQESSLRQAASLREHH 481
+ + E R + + E +Q E+R+ ER + +E ++R+ E
Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ---EEKM 473
Query: 482 RKQLQDLSGQHQQELASQ-LAQFKVEMAEREERQQQVAEDYE----LRLARE---QARVC 533
+KQ +++ Q ++E Q L + K ++ E+E+ Q+Q + +E +R E Q +
Sbjct: 474 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533
Query: 534 ELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTT 571
Q ++ E+Q E E+++ Q WD+ ++ T
Sbjct: 534 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571
Score = 76.6 bits (187), Expect = 9e-14
Identities = 77/422 (18%), Positives = 192/422 (45%), Gaps = 28/422 (6%)
Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260
E + + ++ E +Q++ ++D + + ++ + + W + E R E
Sbjct: 375 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434
Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320
QE+ + + +++E + E+ + E E + REQE +Q E +EE++ RL
Sbjct: 435 QEKKTRDQEEKMQEEERIREREKKMREEEETM-REQEEKMQKQEENMWEQEEKEWQQQRL 493
Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALEEERQTWAQ-----QEHQLKEHYQ 374
++++ + ++E+ + ++ E E + +E++ W Q QE Q+ E +
Sbjct: 494 PEQKEK--LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 375 ALQEESQA---QLEREKEKSQREAQAAWETQHQL---ALVQSEVRRLEGELDTARRERDA 428
++++ Q Q ER ++K+Q + + W+ + ++ ++ +++ E + R + +
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 429 LQLEMSLVQARYE-----SQRIQLESELAVQLEQRVTERLAQ--AQESSLRQAASLREHH 481
+Q + +Q + E +++Q + E + E+++ E+ + Q+ Q L EH
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 482 RKQLQDLSGQHQQELASQLAQFKVEMAEREER---QQQVAEDYELRLAREQARVCELQSG 538
+ Q Q+ Q Q+E + + + + E+E++ Q+++ E+ +R ++ R E +
Sbjct: 672 KMQEQE-KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR--EEEEM 728
Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERR 598
++ EE+ E E++Q + W++ ++ P E +E+ +
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Query: 599 VW 600
+W
Sbjct: 789 IW 790
Score = 66.6 bits (161), Expect = 1e-10
Identities = 72/345 (20%), Positives = 147/345 (42%), Gaps = 18/345 (5%)
Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA----ERTEVLRGLQEEHQAAELTRSKQQETVTRLE 282
++D M EQ +K + + W++ E + + + +E + E R +++E R E
Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601
Query: 283 QSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEE------RDA 336
+ + E +EQE +Q E+ +EE+ EQ+ QEE R
Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 337 ARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLE-----REKEKS 391
+ +L EH +++ E+E + W Q++ + K Q + Q ++ RE+EK
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721
Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451
RE + Q + Q E + + E + E+ Q E Q R Q+ +L
Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781
Query: 452 AVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVE--MAE 509
+Q ++++ E+ + ++ + E R Q + + GQ ++ + + E M
Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQ-EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG 840
Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
+EE+ E E ++ ++ ++ E + + EE+ E E+++
Sbjct: 841 QEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885
Score = 45.4 bits (106), Expect = 2e-04
Identities = 51/203 (25%), Positives = 86/203 (42%), Gaps = 35/203 (17%)
Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEM-------------------SLVQA 438
A E Q L+ V + ++ + ++ +ERDAL LE+ L A
Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA 237
Query: 439 RYESQRIQLESELAVQLEQRVTERLAQAQESSL-----RQAASLREHHRKQLQDLSGQHQ 493
E IQL + + +R L Q Q ++L RQ LRE +K + +
Sbjct: 238 ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297
Query: 494 QELASQLAQFKVEMAEREE---RQQQVAEDYELRL------AREQARVCELQSGNQQLEE 544
QE +L + + +M E+EE RQ++ + E L REQ + E + Q+ EE
Sbjct: 298 QE--ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355
Query: 545 QRVELVERLQAMLQAHWDEANQL 567
+ E E+++ + W + +L
Sbjct: 356 KMWEQEEKMREQEEKMWRQEERL 378
Score = 33.1 bits (74), Expect = 1.2
Identities = 29/159 (18%), Positives = 73/159 (45%), Gaps = 7/159 (4%)
Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA------ERTEVLRGLQEEHQAAELTRSKQQETVTR 280
+++ M EQ +K + E W + E + E R +++ + E + ++QE +
Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791
Query: 281 LEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAG 340
E+ + + E + ++E R Q+ + EE+ ++ ++++ QEE+ +
Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG-QEEKMWGQEE 850
Query: 341 QLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379
++ E + + + +EE+ +++ + +E QEE
Sbjct: 851 KMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 82.4 bits (202), Expect = 2e-15
Identities = 90/449 (20%), Positives = 198/449 (44%), Gaps = 51/449 (11%)
Query: 148 RPLQDLSPSSSAQALEELFPRYTSLRPGPPL-----NPPDFQGLRDALDSEHTRRKHCER 202
+PL L P + EE G P+ + + L+ + + K C+
Sbjct: 246 KPLPQLEPQAEVFTKEE-----NPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE 300
Query: 203 HIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQE 262
IQS + + L + K+ + EQLD+ L + + + H AE+T+++ L++
Sbjct: 301 TIQSHKEQCTLLTSE----------KEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350
Query: 263 EHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER-------ETLEEERQA 315
E + + ++ + E +E +E+E A+L+ R + E E++ ++
Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEM--KEEEIAQLRSRIKQMTTQGEELREQKEKS 408
Query: 316 LTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEH--- 372
E ++ Q+ +A R + +++T+ EEER + Q+ ++K+
Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468
Query: 373 ------------YQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420
Q L E+ A+ E+E K + + ++ Q ++AL +S+ L+ +
Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528
Query: 421 TARRER---DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477
++E + L+L+ + E++ L+ E A R+ E L + E SL++ +
Sbjct: 529 KEQQESLALEELELQKKAILTESENKLRDLQQE-AETYRTRILE-LESSLEKSLQENKNQ 586
Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQS 537
+ L+ +H +E+ + + K E+ E + QQ +L++ ++Q + E++
Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTEL-ESLKHQQDALWTEKLQVLKQQYQT-EMEK 644
Query: 538 GNQQLEEQRVELVERLQAMLQAHWDEANQ 566
++ E+++ L++ + + QAH +E N+
Sbjct: 645 LREKCEQEKETLLKDKEIIFQAHIEEMNE 673
Score = 78.2 bits (191), Expect = 3e-14
Identities = 94/408 (23%), Positives = 194/408 (47%), Gaps = 79/408 (19%)
Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQ--------------QQLAVAVAADRKKD----TM 231
L + + ++ ++ +TR+LEL+ + LAV + A++ K T+
Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607
Query: 232 IEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAA-ELTRSK---QQETVTRLEQSLSE 287
+ + KT ++ ++ +A TE L+ L++++Q E R K ++ET+ + ++ + +
Sbjct: 608 MVEKHKTELESLK--HQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665
Query: 288 A-MEALNREQ-ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEH 345
A +E +N + E ++Q E E+L E + ++ VL+++ D +
Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK------- 718
Query: 346 RELETLRAALEEERQTWAQQ-EHQLKEHYQALQEESQA------QLE---REKEKSQREA 395
+ L A ++E++ QQ + +KEH ++Q +A QLE +E++K +E
Sbjct: 719 ---QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775
Query: 396 QAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQAR---YESQRIQLESELA 452
QA E ++++++R EGEL A + D Q S + YE Q QL+ +L
Sbjct: 776 QAHVEN------LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829
Query: 453 VQLEQRV--TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAER 510
+R+ T+++A+ E+ + + + H+ Q+QDL + Q + + +E
Sbjct: 830 DLETERILLTKQVAEV-EAQKKDVCTELDAHKIQVQDL-----------MQQLEKQNSEM 877
Query: 511 EERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQ 558
E++ + + + YE +L + GN++ E+ + LVE+ +LQ
Sbjct: 878 EQKVKSLTQVYESKL----------EDGNKEQEQTKQILVEKENMILQ 915
Score = 72.0 bits (175), Expect = 2e-12
Identities = 83/399 (20%), Positives = 180/399 (45%), Gaps = 50/399 (12%)
Query: 191 DSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHE 250
+ E T H E Q Q R+++L+ A A + +MI L + L + ++
Sbjct: 1758 EKEETVSSHFEMRCQ-YQERLIKLEH----AEAKQHEDQSMIGHLQEELEEKNKKYSLIV 1812
Query: 251 AERTEVLRG---------LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
A+ E G L+ + T +++ T LEQ + E L R++E R+
Sbjct: 1813 AQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRV 1872
Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQL----------SEHRELETL 351
+ E + E+ QAL +++ + +L+E + L ++H +LE
Sbjct: 1873 EMEELTSKYEKLQALQ-QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931
Query: 352 RAALEEERQTWAQQEHQLKEHYQALQEESQAQLE-REKEKSQREAQAAWETQHQLALV-Q 409
A E E+Q ++ +L++ + L++E Q +LE +KE Q + + Q L L
Sbjct: 1932 LAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN 1991
Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLE-QRVTERLAQAQE 468
S +++L E +T +++ +LEM++ + ++Q ++ E + Q E ++ +++A+ +
Sbjct: 1992 STLKQLMREFNTQLAQKEQ-ELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050
Query: 469 SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAE--------- 519
R A K+ +++ ++E+ +++ + ++ E +++ QQ E
Sbjct: 2051 DLKRTA--------KRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDN 2102
Query: 520 ----DYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554
+ + +LA++ + + + Q+ EQ L +RL+
Sbjct: 2103 VTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141
Score = 70.1 bits (170), Expect = 9e-12
Identities = 120/592 (20%), Positives = 241/592 (40%), Gaps = 63/592 (10%)
Query: 3 TSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTS 62
T ++P S E ++ D + L + V Q R ++ L S
Sbjct: 259 TKEENPESD--GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK 316
Query: 63 PP-HEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDP 121
E LD QEL + K+L + +K I ++ + ++ + Q
Sbjct: 317 EALQEQLDERLQELEKI------KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETK 370
Query: 122 LIPGAGSERREEDSFDSDSTATLLNTR--PLQDLSPSSSAQALEELFPRYTSLRPGPPLN 179
E +EE+ S + T+ L++ S A EEL ++ +
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430
Query: 180 PPDFQGLRDALDSE-HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKT 238
+ L+ +D + T K E SLQ + ++Q++ D K + EQ+ K
Sbjct: 431 ----RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV-----DVMKKSSEEQIAKL 481
Query: 239 LARVVEGWNRHEAERTEVLRGLQEEHQ-----AAELTRSKQQETVTRLEQSLSEAMEALN 293
+ R E E T+ L+ + E Q A E ++S+ + EQ S A+E L
Sbjct: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELE 541
Query: 294 REQESARLQQRERETLEEERQALTLR---LEAEQQRCCVLQEERDAARAGQLSEHRELET 350
Q+ A L + E + + +++A T R LE E LQE ++ ++ L+ H E E
Sbjct: 542 L-QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK--DLAVHLEAEK 598
Query: 351 -----------------LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQR 393
L + ++ W ++ LK+ YQ E+ + + E+EKE +
Sbjct: 599 NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658
Query: 394 EAQAAWE---------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQR 444
+ + ++ T +L + Q+E+ L EL + R L+ E+S+++ + + +
Sbjct: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
Query: 445 IQLESELAVQL--EQRVTERLAQAQESSLRQAASLREHHRKQLQDL---SGQHQQELASQ 499
+LE+++ Q Q+ + + + E S+++ + QL+ L +H +E +
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778
Query: 500 LAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVE 551
+ + ++ E QQ + ++ + + A + ++ +QL + + +L++
Sbjct: 779 VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830
Score = 66.2 bits (160), Expect = 1e-10
Identities = 115/524 (21%), Positives = 218/524 (41%), Gaps = 73/524 (13%)
Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERRE 132
Q+L +G EK+ + K+ + I +E+ ++ L+T +++E
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET----------------KKKE 1607
Query: 133 EDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDS 192
+ + + + L+D S SA L EL + + Q L +
Sbjct: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAEL-----KRKAEQKIAAIKKQLLSQMEEK 1662
Query: 193 EHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE 252
E +K E H+ L T++ E ++++ + + K ++ +TL +V ++ A
Sbjct: 1663 EEQYKKGTESHLSELNTKLQEREREVHI---LEEKLKSVESSQSETL--IVPRSAKNVAA 1717
Query: 253 RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR---EQESARLQQRERETL 309
TE QEE + + +E ++ L+++L+E + L R E+E E
Sbjct: 1718 YTE-----QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772
Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAAL---EEERQTWAQQE 366
+ER EA+Q D + G L E E + + +L + + +
Sbjct: 1773 YQERLIKLEHAEAKQ--------HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNN 1824
Query: 367 HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426
Q K++ + + ++ Q L+ EKE + + + + + Q EV R+E E T++ E+
Sbjct: 1825 IQAKQNLENVFDDVQKTLQ-EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEK 1883
Query: 427 -DAL-QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHR-- 482
AL Q++ + + +S+ + + ++ AQ + + A + RE +
Sbjct: 1884 LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
Query: 483 -------KQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELR-------LARE 528
K L+ L +HQQEL ++ EREE+ +Q ED EL+ L RE
Sbjct: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYD---QEREEKIKQEQEDLELKHNSTLKQLMRE 2000
Query: 529 QARVCELQSGNQQLEEQRVELVERLQ----AMLQAHWDEANQLL 568
+L Q+LE E + + Q +L++H +E NQLL
Sbjct: 2001 FN--TQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL 2042
Score = 61.6 bits (148), Expect = 3e-09
Identities = 74/376 (19%), Positives = 174/376 (46%), Gaps = 41/376 (10%)
Query: 195 TRRKHCERHIQSLQTRVL-------ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247
+R HC+ ++ +L EL+ QL +++T+ + ++ E N
Sbjct: 1248 SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT---EEQNTLNISFQQATHQLEEKEN 1304
Query: 248 RHEAERTEV------LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301
+ ++ + ++ LQ+E + S+++ +T+L++ LSE + A+ +E +
Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364
Query: 302 QQRERETLEEERQALTLRLE------AEQQRCCVLQEERDAARAGQLSEHRELETLRAAL 355
++ E +L ++ L ++L+ ++ L+++ D + L + ++L L
Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424
Query: 356 EEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE-VRR 414
+E+ + +Q + ++++Q++ + + + +E Q E + + A + E +
Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRF-TQHQNTVKELQIQLELKSKEAYEKDEQINL 1483
Query: 415 LEGELDTARRERDALQLEMSLVQARYESQRIQLESEL------AVQLEQRVTERLAQAQE 468
L+ ELD + D L+ EM +++ E + LE+EL ++LE +T++ + +
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIE- 1542
Query: 469 SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528
SL E + Q +H +EL +L F+ E+ E ++ + + AE+ L L +
Sbjct: 1543 -------SLNEVLKNYNQQKDIEH-KELVQKLQHFQ-ELGEEKDNRVKEAEEKILTLENQ 1593
Query: 529 -QARVCELQSGNQQLE 543
+ EL++ ++LE
Sbjct: 1594 VYSMKAELETKKKELE 1609
Score = 57.8 bits (138), Expect = 5e-08
Identities = 64/313 (20%), Positives = 151/313 (48%), Gaps = 32/313 (10%)
Query: 211 VLELQQQLAVAV-AADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAEL 269
+L+ Q L+ V ++K + +EQ+D + E + ++ T+ ++E EL
Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLEL 1469
Query: 270 TRSKQQETVTRLEQS--LSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRC 327
K +E + EQ L E ++ N+ + + + + ++ E++++ L E + Q
Sbjct: 1470 ---KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES-NLETELKSQTA 1525
Query: 328 CVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLERE 387
+++ E + + E+E+L L+ Q Q++ + KE Q LQ + L E
Sbjct: 1526 RIMELEDHITQ-----KTIEIESLNEVLKNYNQ---QKDIEHKELVQKLQHFQE--LGEE 1575
Query: 388 KEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL 447
K+ +EA+ ++ ++++V ++ EL+T ++E + + L + + ++ +L
Sbjct: 1576 KDNRVKEAE------EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL 1629
Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507
ESE A +LA+ + + ++ A++++ Q+++ Q+++ S L++ ++
Sbjct: 1630 ESESAA--------KLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681
Query: 508 AEREERQQQVAED 520
ER ER+ + E+
Sbjct: 1682 QER-EREVHILEE 1693
Score = 52.8 bits (125), Expect = 1e-06
Identities = 79/405 (19%), Positives = 174/405 (42%), Gaps = 62/405 (15%)
Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241
+ + L L R E + L+ + +++Q+L + D +K+ +Q+D +
Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKM--DEQKNHHQQQVDSIIKE 742
Query: 242 VVEGWNRHEAERTEVLRGLQ----------EEHQAAELTRSKQQETVTRLEQSLSEAMEA 291
R E + + L+ +EHQA + + R E L +A
Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHV---ENLEADIKRSEGELQQASAK 799
Query: 292 LN---------------REQESARLQQRERETLEEERQALT---LRLEAEQQRCCVLQEE 333
L+ E++ A+LQQ+ + LE ER LT +EA+++ C E
Sbjct: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLD-LETERILLTKQVAEVEAQKKDVCT---E 855
Query: 334 RDAARAGQLSEHRELETLRAALEEERQTWAQ-QEHQLKEHYQALQEESQAQLEREKEKSQ 392
DA + ++LE + +E++ ++ Q E +L++ + ++ Q +E+E Q
Sbjct: 856 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915
Query: 393 REAQAAWETQ---HQLALVQSEVRRLEGELDT----ARRERDALQLEMSLVQARYESQRI 445
E + +L+ + + L E +T ++ + ++ + +Q + + +
Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
Query: 446 QLESELAVQLEQRVTE-------------RLAQAQESSLRQAAS-LREHHRKQLQDLSGQ 491
E++L +LE E +AQA + + A S L + ++Q++ L+
Sbjct: 976 DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035
Query: 492 HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQ 536
H++EL ++ ++ ++ ++ E Q++ +E++L ++ V EL+
Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEI---HEIQLQEKEQEVAELK 1077
Score = 48.9 bits (115), Expect = 2e-05
Identities = 68/350 (19%), Positives = 149/350 (42%), Gaps = 22/350 (6%)
Query: 227 KKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS 286
+K+ MI Q+ + + +E + + + + + L EE++ + K+ E V + + +
Sbjct: 908 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967
Query: 287 EAMEALNREQESARLQQRERETLE---EERQALTLRLEAEQQRCCVLQEERDAARAGQLS 343
E ++ +QE+ ++ E LE +E+Q LE Q + + Q
Sbjct: 968 ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027
Query: 344 EHREL-ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQ 402
+ L E R L + W E +L + + LQE + QL+ EK Q A E +
Sbjct: 1028 QIESLTEVHRRELNDVISIW---EKKLNQQAEELQEIHEIQLQ---EKEQEVA----ELK 1077
Query: 403 HQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTER 462
++ L E + E+ + E ++ +Q + + + + S L Q T+
Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS-----LAQDETKL 1132
Query: 463 LAQAQESSLRQAASLREHH--RKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520
A ++ + SL+E+ ++QL +L +E ++++ ++ +E Q +
Sbjct: 1133 KAHLEKLEVDLNKSLKENTFLQEQLVELK-MLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191
Query: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLST 570
+E + + E + +++L Q ++ +A+L+A +E + S+
Sbjct: 1192 HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS 1241
Score = 48.5 bits (114), Expect = 3e-05
Identities = 93/470 (19%), Positives = 181/470 (38%), Gaps = 105/470 (22%)
Query: 198 KHCERHIQSL---QTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT 254
K H+ SL +T++ ++L V + K++T +++ L + E R +E T
Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175
Query: 255 EVLRGLQEEHQAAELTRSKQQETVT-------RLEQSLSEAMEALNREQESARLQQRERE 307
L+ EE Q+ + + K +++ +L + L+ ++ ++ E A L+ + E
Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE-ALLEAKTNE 1234
Query: 308 TLE---EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT--- 361
+ + A+ R+ Q R ++E A + ELE L EE+ T
Sbjct: 1235 LINISSSKTNAILSRISHCQHRTTKVKE----ALLIKTCTVSELEAQLRQLTEEQNTLNI 1290
Query: 362 -WAQQEHQLKEHYQALQEESQ--AQLEREKEKSQREA----QAAWETQHQLALVQSEVRR 414
+ Q HQL+E ++ L EKE Q+E QAA E + + ++ E+
Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350
Query: 415 LEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV------------QLEQRVTER 462
+ + E ++E+S + + +QL++ +++ Q ++ E
Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410
Query: 463 LAQAQESSLRQAASLRE----------------HHRKQLQDLSGQHQ------------- 493
L Q Q+ S + +E +K+ Q QHQ
Sbjct: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK 1470
Query: 494 ---------------QELASQLAQF---KVEMAEREERQQQVAEDYELRLAREQARVCEL 535
+EL Q +F K EM + + + ++ + E L + AR+ EL
Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530
Query: 536 QSG------------------NQQLEEQRVELVERLQAMLQAHWDEANQL 567
+ NQQ + + ELV++LQ + ++ N++
Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Score = 46.6 bits (109), Expect = 1e-04
Identities = 80/411 (19%), Positives = 167/411 (40%), Gaps = 74/411 (18%)
Query: 205 QSLQTRVLELQQQLAVAVAADR---------KKDTMIEQLDKTLARVVEGWNRHEAERTE 255
Q + +LQQ LA A A+ + + EQLD+ G + A++ +
Sbjct: 7 QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66
Query: 256 V----LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR-EQESARLQQRERETLE 310
+ + L L RS +E++ R + + E+LNR + +S+ ++
Sbjct: 67 LRVPSVESLFRSPIKESLFRSSSKESLVR-----TSSRESLNRLDLDSSTASFDPPSDMD 121
Query: 311 EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLK 370
E + L + L++ + ++ LR +E ++ + +L
Sbjct: 122 SEAEDLV-------------------GNSDSLNKEQLIQRLRR-MERSLSSYRGKYSELV 161
Query: 371 EHYQALQEES---QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427
YQ LQ E Q L + ++KS R E + +L + Q + L+ E D + E+D
Sbjct: 162 TAYQMLQREKKKLQGILSQSQDKSLRRIA---ELREELQMDQQAKKHLQEEFDASLEEKD 218
Query: 428 ----ALQLEMSLVQARYESQRI---------QLESELAVQLEQR---------VTERLAQ 465
LQ ++SL++ R + + QLE + V ++ V + +
Sbjct: 219 QYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSV 278
Query: 466 AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525
+L+Q +E+ K+ ++ H+++ ++ + + +ER Q++ + +L +
Sbjct: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM 338
Query: 526 AREQARVCELQSGN---QQLEEQR----VELVERLQAMLQAHWDEANQLLS 569
A + + +L+ +QLE+ + E ++ L+ +E QL S
Sbjct: 339 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.126 0.354
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,429,877
Number of Sequences: 37866
Number of extensions: 2227272
Number of successful extensions: 37287
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 489
Number of HSP's successfully gapped in prelim test: 1674
Number of HSP's that attempted gapping in prelim test: 16791
Number of HSP's gapped (non-prelim): 10247
length of query: 903
length of database: 18,247,518
effective HSP length: 111
effective length of query: 792
effective length of database: 14,044,392
effective search space: 11123158464
effective search space used: 11123158464
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.