BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|191252785 centrobin, centrosomal BRCA2 interacting protein isoform alpha [Homo sapiens] (903 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|191252785 centrobin, centrosomal BRCA2 interacting protein is... 1776 0.0 gi|80861396 centrobin, centrosomal BRCA2 interacting protein iso... 1763 0.0 gi|148746195 trichohyalin [Homo sapiens] 107 7e-23 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 104 4e-22 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 104 4e-22 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 104 4e-22 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 104 4e-22 gi|41322916 plectin 1 isoform 6 [Homo sapiens] 104 4e-22 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 104 4e-22 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 104 4e-22 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 104 4e-22 gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 89 1e-17 gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 89 1e-17 gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 89 1e-17 gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] 88 3e-17 gi|16262452 cingulin [Homo sapiens] 87 5e-17 gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 87 7e-17 gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 87 7e-17 gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] 86 2e-16 gi|21735548 centrosomal protein 2 [Homo sapiens] 86 2e-16 gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 85 3e-16 gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 85 3e-16 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 84 8e-16 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 84 8e-16 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 84 8e-16 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 84 8e-16 gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 83 1e-15 gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 82 2e-15 gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 82 2e-15 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 82 2e-15 >gi|191252785 centrobin, centrosomal BRCA2 interacting protein isoform alpha [Homo sapiens] Length = 903 Score = 1776 bits (4600), Expect = 0.0 Identities = 903/903 (100%), Positives = 903/903 (100%) Query: 1 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS Sbjct: 1 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60 Query: 61 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD Sbjct: 61 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120 Query: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP Sbjct: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180 Query: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA Sbjct: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240 Query: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR Sbjct: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300 Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ Sbjct: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360 Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD Sbjct: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420 Query: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH Sbjct: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 Query: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ Sbjct: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540 Query: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW Sbjct: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600 Query: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL Sbjct: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660 Query: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV Sbjct: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720 Query: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH Sbjct: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780 Query: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTD 840 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTD Sbjct: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGTD 840 Query: 841 GRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGG 900 GRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGG Sbjct: 841 GRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKTEKPPARKKSGHPAPSSMRSRGG 900 Query: 901 VWR 903 VWR Sbjct: 901 VWR 903 >gi|80861396 centrobin, centrosomal BRCA2 interacting protein isoform beta [Homo sapiens] Length = 925 Score = 1763 bits (4567), Expect = 0.0 Identities = 903/925 (97%), Positives = 903/925 (97%), Gaps = 22/925 (2%) Query: 1 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS Sbjct: 1 MATSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPS 60 Query: 61 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD Sbjct: 61 TSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRD 120 Query: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP Sbjct: 121 PLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNP 180 Query: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA Sbjct: 181 PDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLA 240 Query: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR Sbjct: 241 RVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR 300 Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ Sbjct: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360 Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD Sbjct: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420 Query: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH Sbjct: 421 TARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 Query: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ Sbjct: 481 HRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ 540 Query: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW Sbjct: 541 QLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVW 600 Query: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL Sbjct: 601 TMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPDL 660 Query: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV Sbjct: 661 TSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLETV 720 Query: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH Sbjct: 721 PQNNENPSVDLLPPKSGPLTVPSWEEAPQVPRIPPPVHKTKVPLAMASSLFRVPEPPSSH 780 Query: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEH---- 836 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEH Sbjct: 781 SQGSGPSSGSPERGGDGLTFPRQLMEVSQLLRLYQARGWGALPAEDLLLYLKRLEHSGYK 840 Query: 837 ------------------SGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT 878 SGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT Sbjct: 841 PGRKEEGFSGWKLDYGEWSGTDGRGDNVPRRNTDSRLGEIPRKEIPSQAVPRRLATAPKT 900 Query: 879 EKPPARKKSGHPAPSSMRSRGGVWR 903 EKPPARKKSGHPAPSSMRSRGGVWR Sbjct: 901 EKPPARKKSGHPAPSSMRSRGGVWR 925 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 107 bits (266), Expect = 7e-23 Identities = 99/394 (25%), Positives = 182/394 (46%), Gaps = 25/394 (6%) Query: 181 PDFQGLR--DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKT 238 PD + LR + L+ R+ ++ + Q RV + +++ RK++T++ + ++ Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEW-----RKRETVLRKEEEK 259 Query: 239 LARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQES 298 L R E E LR L+ + E +QQ+ R EQ L E REQ+ Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319 Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358 R +Q+ER +EER+ LR E E++R L+ E++ E RE + R EE Sbjct: 320 ERREQQERREQQEERREQQLRREQEERREQQLRREQE-------EERREQQLRREQEEER 372 Query: 359 RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGE 418 R+ ++E QL+ Q +E+ + ++ + + Q + + QL Q R E E Sbjct: 373 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432 Query: 419 LDTARRERDALQLEMSLVQARYESQR--IQLESELAVQLEQRVTERLAQAQESSLRQA-A 475 + E++ + + Q E +R ++ E E ++R ++L + QE R+ Sbjct: 433 RHEQKHEQERREQRLKREQ---EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489 Query: 476 SLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER-QQQVAEDYELRLAREQARVCE 534 L E R++ Q+ Q + + + +++ E EER QQ++ + +LR +E+ R Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549 Query: 535 LQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568 L ++ EE+R+E R Q + + + +QLL Sbjct: 550 L----KREEEKRLEQERREQRLKREQEERRDQLL 579 Score = 97.4 bits (241), Expect = 5e-20 Identities = 116/464 (25%), Positives = 192/464 (41%), Gaps = 53/464 (11%) Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188 + EE + T LQ+ P + EE L + Q LR Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE----------EEQLRKLERQELRR 288 Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 E +++ R Q + + E ++Q +++ E+ ++ L R Sbjct: 289 ERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR------E 342 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET 308 E R + LR QEE + + R +Q+E R EQ L + L REQ+ R QQ RE Sbjct: 343 QEERREQQLRREQEEERREQQLRREQEEE--RREQQLRREQQ-LRREQQLRREQQLRREQ 399 Query: 309 LEEERQALT----LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQ 364 Q L LR E + +R L+ E++ R Q E E +EER+ W + Sbjct: 400 QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459 Query: 365 QEHQLKEHYQAL--------QEESQAQ----LEREKEKSQREAQAAWETQHQLALVQSEV 412 +E + + H Q QEE + + LE E+ + Q+E + + Q + + Sbjct: 460 REEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRL 519 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR 472 +R E E R + L+ E L + + E + L+ E +LEQ E+ + ++ R Sbjct: 520 KRQEEE----ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERR 575 Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAR----- 527 RE R+Q Q L + ++ L +L + +VE E+EER++Q + E R Sbjct: 576 DQLLKREEERRQ-QRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLL 634 Query: 528 -----EQARVCELQSGNQQLEEQRV---ELVERLQAMLQAHWDE 563 E+ R +L+ Q+ EQR+ E ERL+ L+ +E Sbjct: 635 KSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEE 678 Score = 89.0 bits (219), Expect = 2e-17 Identities = 102/381 (26%), Positives = 168/381 (44%), Gaps = 36/381 (9%) Query: 184 QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243 Q R L+ E RR+H +L + LQ+QL RK+ ++++ ++ L R Sbjct: 872 QKWRWQLEEERKRRRH------TLYAKPA-LQEQL-------RKEQQLLQEEEEELQRE- 916 Query: 244 EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ 303 R + R E R +EE Q + ++E + R E+ E + ++ +LQQ Sbjct: 917 ---EREKRRRQEQERQYREEEQLQQ-----EEEQLLREEREKRRRQERERQYRKDKKLQQ 968 Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 +E + L EE + R E+++ +EE L E RE R E ERQ Sbjct: 969 KEEQLLGEEPEK---RRRQEREKKYREEEELQQEEEQLLREEREK---RRRQEWERQYRK 1022 Query: 364 QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423 + E Q +E Q L+EE + + +E+E+ RE + + + QL + E RR + R Sbjct: 1023 KDELQQEEE-QLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR 1081 Query: 424 RERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK 483 +E + Q E L++ E +R Q + + R E L Q +E LR+ R Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQER-----ERQCREEEELQQEEEQLLREEREKRRRQEL 1136 Query: 484 QLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLE 543 + Q + Q+ QL + + E R+E ++Q E+ EL+ EQ E + Q+ E Sbjct: 1137 ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERE 1196 Query: 544 EQ-RVELVERLQAMLQAHWDE 563 Q R E + Q Q + DE Sbjct: 1197 RQYREEEELQRQKRKQRYRDE 1217 Score = 88.6 bits (218), Expect = 2e-17 Identities = 115/433 (26%), Positives = 194/433 (44%), Gaps = 59/433 (13%) Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADR----------KKDTMIEQLD 236 R+ + H ++ ER Q L+ E + L +R K+D E+ + Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRE 486 Query: 237 KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQ 296 + L E + R + LR QEE + L R +++E RL+Q L + L REQ Sbjct: 487 RWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEE---RLQQRLRSEQQ-LRREQ 542 Query: 297 ESAR--LQQRERE-TLEEERQALTLRLEAEQQRCCVL--QEERDAARAGQLSEHR----- 346 E R L +RE E LE+ER+ L+ E E++R +L +EER R + E R Sbjct: 543 EERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602 Query: 347 -ELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQL 405 E R EE R+ ++E +E Q L +S+ Q ER +++ +RE Q E + Q Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLL-KSEEQEERRQQQLRREQQ---ERREQR 658 Query: 406 ALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ 465 + E RLE L +RE + + E L + E R +++S + Q +E A Sbjct: 659 LKREEEEERLEQRL---KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESE--AD 713 Query: 466 AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 A++S + +E R++ + + ++E S+L + E A R++++++ D+ + Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRE--SELQWQEEERAHRQQQEEEQRRDFTWQW 771 Query: 526 AREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPS 585 E+ + + G Q+L R L E+ + L+A +E Q L Sbjct: 772 QAEE----KSERGRQRL-SARPPLREQRERQLRA--EERQQREQRFL------------- 811 Query: 586 SPGPQEPEKEERR 598 P+E EKE+RR Sbjct: 812 ---PEEEEKEQRR 821 Score = 87.0 bits (214), Expect = 7e-17 Identities = 89/382 (23%), Positives = 162/382 (42%), Gaps = 35/382 (9%) Query: 191 DSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHE 250 + E ++ +R + + + LE ++QL R++ +++ + L E E Sbjct: 813 EEEEKEQRRRQRREREKELQFLEEEEQLQ-----RRERAQQLQEEEDGLQEDQERRRSQE 867 Query: 251 AERTEVLRG-LQEEHQAAELT---RSKQQETVTRLEQSLSEAMEALNREQ---------- 296 R + R L+EE + T + QE + + +Q L E E L RE+ Sbjct: 868 QRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQE 927 Query: 297 ----ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLR 352 E +LQQ E + L EER+ + Q R ++++ G+ E R Sbjct: 928 RQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR----- 982 Query: 353 AALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEV 412 +E + + ++E +E Q L+EE + + +E E+ R+ + + QL + E Sbjct: 983 --RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREK 1040 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR 472 RRL+ R E + Q E L+ E++R Q ++ + R E L Q +E LR Sbjct: 1041 RRLQERERQYREEEELQQEEEQLLGEERETRRRQ-----ELERQYRKEEELQQEEEQLLR 1095 Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532 + R ++ Q + Q+ QL + + E R+E ++Q E+ E++ EQ Sbjct: 1096 EEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLR 1155 Query: 533 CELQSGNQQLEEQRVELVERLQ 554 E + +Q E++ E LQ Sbjct: 1156 EEPEKRRRQELERQYREEEELQ 1177 Score = 82.0 bits (201), Expect = 2e-15 Identities = 133/539 (24%), Positives = 208/539 (38%), Gaps = 75/539 (13%) Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQL-----------QTMLQTSRDTAYRDP 121 Q L R LE+ LK+++ + E E R Q Q +L++ R Sbjct: 588 QRLKREQEERLEQRLKREEVER--LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645 Query: 122 LIPGAGSERRE--------EDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLR 173 + ERRE E+ + R Q+L+ QA E + R Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRI---- 701 Query: 174 PGPPLNPPDFQGLRDALDSE-HTRRKHCE----RHIQSLQTRVLELQQQLAVAVAADRKK 228 P + DA S+ ++R + E R Q + R E + Q A R++ Sbjct: 702 ---PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQ 758 Query: 229 DTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEA 288 ++ D T W E++E RG Q L ++++ Q + Sbjct: 759 QEEEQRRDFT-------WQWQAEEKSE--RGRQRLSARPPLREQRERQLRAEERQQREQR 809 Query: 289 MEALNREQESARLQQRERET----LEEERQALTLRLEAEQQRCCVLQEERDAARAGQ--- 341 E+E R Q+RERE LEEE Q L R A+Q LQEE D + Q Sbjct: 810 FLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQ-----LQEEEDGLQEDQERR 863 Query: 342 -LSEHRELETLRAALEEERQTWAQQ-------EHQLKEHYQALQEESQAQLEREKEKSQR 393 E R + R LEEER+ + QL++ Q LQEE + +L+RE+ + +R Sbjct: 864 RSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEE-ELQREEREKRR 922 Query: 394 EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV 453 + + + + L Q E + L E + RR+ Q + E Q + E E Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982 Query: 454 QLEQ----RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509 + E+ R E L Q +E LR+ R + Q Q+ QL + + E Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042 Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568 +ER++Q E+ EL+ EQ ++ E +R + +ER + E QLL Sbjct: 1043 LQERERQYREEEELQQEEEQLL-------GEERETRRRQELERQYRKEEELQQEEEQLL 1094 Score = 81.6 bits (200), Expect = 3e-15 Identities = 90/334 (26%), Positives = 150/334 (44%), Gaps = 20/334 (5%) Query: 190 LDSEHTRRKHCERHIQS--LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247 L+ + RR+ ER Q R E QQQL +++D + D+ L + E Sbjct: 1583 LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLR------QERDRKFRE-DEQLLQEREEQQ 1635 Query: 248 RHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERE 307 H ER + L+EE Q R +QQ R + E E++ R Q+R+R+ Sbjct: 1636 LHRQERDR--KFLEEEPQLRRQER-EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRK 1692 Query: 308 TLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEH 367 EEE+Q L +++ LQEE+ R + RE E LR E+E+ ++ Sbjct: 1693 FREEEQQ-----LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747 Query: 368 QLKEHYQALQEESQAQLER-EKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426 ++ E Q E + QL R E+++ RE + + + + L E R E + R+ER Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807 Query: 427 DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486 + QL +Y + QL+ E Q ++ +R +A+E Q S RE ++ Q Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREE-QELWQ 1866 Query: 487 DLSGQHQQELASQLAQFKVEMAEREE-RQQQVAE 519 + + +QE +L + + ++EE R +QV E Sbjct: 1867 EEEQKRRQERERKLREEHIRRQQKEEQRHRQVGE 1900 Score = 78.2 bits (191), Expect = 3e-14 Identities = 109/405 (26%), Positives = 175/405 (43%), Gaps = 59/405 (14%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E +R+ ER + + ELQQ+ + +R+K R + W R Sbjct: 974 LGEEPEKRRRQEREKKYREEE--ELQQEEEQLLREEREK------------RRRQEWERQ 1019 Query: 250 EAERTEVLRGLQEEHQAAELTRSK----QQETVTRLEQSLSEAMEAL-NREQESARLQQR 304 ++ E+ QEE Q R K ++E R E+ L + E L E+E+ R Q+ Sbjct: 1020 YRKKDELQ---QEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076 Query: 305 ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAAL-EEERQT-- 361 ER+ +EE L+ E EQ ++ R R Q E EL+ L EER+ Sbjct: 1077 ERQYRKEEE----LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132 Query: 362 -------WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRR 414 + ++E +E Q L+EE + + +E E+ RE + + + QL + E RR Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192 Query: 415 LEGELDTARRERDALQLEMSLVQARYESQRIQL------ESELAVQ-----LEQRVTERL 463 E E RE + LQ + + R E QR L E E AV+ + R E+ Sbjct: 1193 QERE--RQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQF 1250 Query: 464 AQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYEL 523 Q ++S LR S ++ LQ L G+ QQE + + + + +R +++ E E Sbjct: 1251 RQLEDSQLRDRQS-----QQDLQHLLGE-QQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304 Query: 524 RLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568 + A+ + R + Q Q L E+R E +R + + E QLL Sbjct: 1305 KEAKRRDR--KSQEEKQLLREEREE--KRRRQETDRKFREEEQLL 1345 Score = 77.8 bits (190), Expect = 4e-14 Identities = 110/443 (24%), Positives = 194/443 (43%), Gaps = 80/443 (18%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E +H ++H Q + + L+ +Q+ ++D + + E RH Sbjct: 425 LRREQEEERHEQKHEQERREQRLKREQE--------ERRDWLKRE---------EETERH 467 Query: 250 EAERT-EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET 308 E ER + L+ QEE + + +++E R +Q E + L REQE R +QR + Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEER--REQQERRE--QQLRREQEERR-EQRLKRQ 522 Query: 309 LEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 EEER L RL +EQQ L+ E++ R E L EE+R ++E + Sbjct: 523 EEEER--LQQRLRSEQQ----LRREQEERR----------EQLLKREEEKRLEQERREQR 566 Query: 369 LKEHYQALQEESQAQ-LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARR-ER 426 LK QEE + Q L+RE+E+ Q+ + E + + L + EV RLE E +R +R Sbjct: 567 LKRE----QEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKR 622 Query: 427 DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486 + + E + E Q + + +L + ++R +RL + +E + REH ++ + Sbjct: 623 EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERRE 682 Query: 487 DLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQR 546 + +QE A + + ++ + Q Q+ + + R ++ +R Q G ++ +EQ Sbjct: 683 QELAEEEQEQARERIKSRI-----PKWQWQLESEADARQSKVYSRP-RKQEGQRRRQEQE 736 Query: 547 VELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMA 606 E R ++ LQ W E + Q+ E+E+RR +T A Sbjct: 737 -EKRRRRESELQ--WQEEER--------------------AHRQQQEEEQRRDFTWQWQA 773 Query: 607 VALKPVLQQSREARDELPGAPPV 629 ++S R L PP+ Sbjct: 774 E------EKSERGRQRLSARPPL 790 Score = 77.4 bits (189), Expect = 6e-14 Identities = 91/389 (23%), Positives = 160/389 (41%), Gaps = 38/389 (9%) Query: 184 QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243 Q L+ L + R + ER + R ++QL + K+ Q +K L R Sbjct: 1265 QDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREE 1324 Query: 244 EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ 303 R R E R +EE Q L + ++++ + R E+ E L +++ + + Sbjct: 1325 REEKRR---RQETDRKFREEEQ---LLQEREEQPLRRQERDRKFREEELRHQEQGRKFLE 1378 Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ +ER+ L+ E +Q RC +ER+ QL + R+ + EE Q + Sbjct: 1379 EEQRLRRQERERKFLK-EEQQLRC----QEREQ----QLRQDRDRK-----FREEEQQLS 1424 Query: 364 QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423 +QE K +EE Q + + + K E Q + +H+ + ++ + E R Sbjct: 1425 RQERDRKFR----EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHR 1480 Query: 424 RERDALQLEMSLVQARYESQRIQLESELAVQ------LEQRVTERLAQAQESSLRQAASL 477 +ERD LE R E R E EL Q LE+ Q Q L++ L Sbjct: 1481 QERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQL 1540 Query: 478 RE----HHRKQLQDLSGQHQQELASQLAQFKVEMAEREER----QQQVAEDYELRLAREQ 529 R R+Q +D + +++L + + ++ ER+ + +Q+V + R E Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600 Query: 530 ARVCELQSGNQQLEEQRVELVERLQAMLQ 558 + Q G QQL ++R + +LQ Sbjct: 1601 EQQLRRQEGQQQLRQERDRKFREDEQLLQ 1629 Score = 75.9 bits (185), Expect = 2e-13 Identities = 103/404 (25%), Positives = 167/404 (41%), Gaps = 46/404 (11%) Query: 190 LDSEHTRRKHCER----HIQSLQTRVLELQQQLAVAVAAD----------RKKDTMIEQL 235 L S+ RK E H Q Q + L+ +QQL R+++ + ++ Sbjct: 1508 LRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQER 1567 Query: 236 DKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAM---EAL 292 ++ E + E +V R QE + + ++QE +L Q E L Sbjct: 1568 EEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627 Query: 293 NREQESARL--QQRERETLEEERQALTLRLEAEQQ----RCCVLQEERDAARAGQLSEHR 346 +E+E +L Q+R+R+ LEEE Q R E EQQ R +EE + G+ + R Sbjct: 1628 LQEREEQQLHRQERDRKFLEEEPQLR--RQEREQQLRHDRDRKFREEEQLLQEGEEQQLR 1685 Query: 347 ELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLA 406 E R EEE+Q Q+ + + LQEE Q + + + K + E Q ET+ + Sbjct: 1686 RQERDRKFREEEQQLRRQERER-----KFLQEEQQLRRQELERKFREEEQLRQETEQEQL 1740 Query: 407 LVQSEVRRL-----------EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455 Q R++ E +L R+R + E L Q R E Q ES+ + Sbjct: 1741 RRQERYRKILEEEQLRPEREEQQLRRQERDR-KFREEEQLRQEREEQQLRSQESDRKFRE 1799 Query: 456 EQRV-TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQL---AQFKVEMAERE 511 E+++ ER Q R E + QL++ + +QE Q QF + R Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859 Query: 512 ERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQA 555 E Q+ E+ + R + ++ E QQ EEQR V +++ Sbjct: 1860 EEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKS 1903 Score = 74.3 bits (181), Expect = 5e-13 Identities = 104/410 (25%), Positives = 175/410 (42%), Gaps = 54/410 (13%) Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246 R L+ E R+ R + + + E ++Q DRK +QL + Sbjct: 1446 RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ-------- 1497 Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306 R R + LR + E + E +Q R + L E + +E+ R Q R+R Sbjct: 1498 ERDRKFREQELRSQEPERKFLE--EEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555 Query: 307 ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE 366 + EEE+ LR E E+Q+ + ++ERD + + R E R +E+E+Q Q+ Sbjct: 1556 KFREEEQ----LRQEREEQQ--LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEG 1609 Query: 367 HQ---------LKEHYQALQEESQAQLER--------EKEKSQREAQAAWETQHQLALVQ 409 Q +E Q LQE + QL R E+E R + + +H Sbjct: 1610 QQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKF 1669 Query: 410 SEVRRL--EGELDTARR-ERDALQLEMSLVQARYESQR--IQLESELAVQLEQRVTERLA 464 E +L EGE RR ERD E R E +R +Q E +L Q +R Sbjct: 1670 REEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEE 1729 Query: 465 QAQESSLRQAASLREHHRKQLQD---LSGQHQQELASQL--AQFKVEMAEREERQQQ--- 516 Q ++ + ++ +E +RK L++ + +Q+L Q +F+ E R+ER++Q Sbjct: 1730 QLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLR 1789 Query: 517 -------VAEDYELRLAREQARVCELQ-SGNQQLEEQRVELVERLQAMLQ 558 E+ +LR RE+ ++ Q G + EE++++L E+ Q + Q Sbjct: 1790 SQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839 Score = 73.2 bits (178), Expect = 1e-12 Identities = 97/412 (23%), Positives = 174/412 (42%), Gaps = 56/412 (13%) Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246 +D L E + ER + LQ R + R+++ + ++ ++ L E Sbjct: 1023 KDELQQEEEQLLREEREKRRLQERERQY-----------REEEELQQEEEQLLGEERETR 1071 Query: 247 NRHEAERT----EVLRGLQEE--HQAAELTRSKQQETVTRLEQSLSEAMEALNREQ-ESA 299 R E ER E L+ +E+ + E R +++E R E+ L + E L RE+ E Sbjct: 1072 RRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKR 1131 Query: 300 RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLS-EHRELETLRAALEEE 358 R Q+ ER+ EEE E +Q+ +L+EE + R +L ++RE E L+ EEE Sbjct: 1132 RRQELERQYREEE--------EVQQEEEQLLREEPEKRRRQELERQYREEEELQQ--EEE 1181 Query: 359 RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAA-----WETQHQLALVQSEV- 412 + +QE + +E + +EE + Q ++ K++ + E Q + WE + + A+ ++V Sbjct: 1182 QLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVY 1241 Query: 413 ---------RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV---------Q 454 R+LE D+ R+R + Q L+ + E R Q Q Sbjct: 1242 CKGRENEQFRQLE---DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQ 1298 Query: 455 LEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQ 514 LE+ + + S + LRE ++ + + QL Q + E R + + Sbjct: 1299 LEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQER 1358 Query: 515 QQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566 + + ELR + + E + ++ E +R L E Q Q + Q Sbjct: 1359 DRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQ 1410 Score = 72.0 bits (175), Expect = 2e-12 Identities = 79/345 (22%), Positives = 142/345 (41%), Gaps = 43/345 (12%) Query: 259 GLQEEHQAA-----ELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313 GL EE +A L + ++QE R + +E ++ + Q++ERE E E Sbjct: 94 GLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153 Query: 314 QA----------------------------LTLRLEAEQQRCCVLQEERDAARAGQLSEH 345 Q+ R E EQ + C E + QL Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRR 213 Query: 346 RELETLRAALEE-ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQ 404 LE R EE ++Q +Q+ +E + + + L +E+EK Q E E Q Q Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEE-----EPQRQ 268 Query: 405 LALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLA 464 L + E + + E RRER + + ++ + +R Q E E Q E+R ++ Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ-EEERREQQEERREQQER 327 Query: 465 QAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREE---RQQQVAEDY 521 + Q+ R+ RE ++ Q L + ++E Q + + E RE+ R+QQ+ + Sbjct: 328 REQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQ 387 Query: 522 ELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566 +LR ++ R +L+ Q EQ++ ++L+ Q ++ + Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE 432 Score = 57.8 bits (138), Expect = 5e-08 Identities = 114/508 (22%), Positives = 200/508 (39%), Gaps = 76/508 (14%) Query: 69 DGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGS 128 D QE + L EK + ++ + E E ++ + + +L R+T R L Sbjct: 1024 DELQQEEEQLLREEREKR-RLQERERQYREEEELQQEEEQLLGEERETRRRQEL----ER 1078 Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188 + R+E+ + LL P + Q EE L + Q LR+ Sbjct: 1079 QYRKEEELQQEEEQ-LLREEPEKRRRQERERQCREE-----------EELQQEEEQLLRE 1126 Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTM---------IEQLDKTL 239 + E RR+ ER + + V + ++QL R++ + ++Q ++ L Sbjct: 1127 --EREKRRRQELERQYRE-EEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183 Query: 240 ARVVEGWNRHEAERT-----EVLRGLQEEHQAAELTRS--KQQETVTRLEQSLSEAMEAL 292 R + R E ER E+ R +++ E RS K Q + + Sbjct: 1184 LREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCK 1243 Query: 293 NREQESARL----QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHREL 348 RE E R Q R+R++ ++ + L EQQ ERD Sbjct: 1244 GRENEQFRQLEDSQLRDRQSQQDLQHLL-----GEQQ-------ERDR------------ 1279 Query: 349 ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408 E+ER+ W Q++ E Q L+ E Q + +R KSQ E Q E + + Sbjct: 1280 -------EQERRRWQQRDRHFPEEEQ-LEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331 Query: 409 QSEVRRL-EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQ 467 Q R+ E E RE L+ + + R E R Q + ++ EQR+ R + + Sbjct: 1332 QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRL--RRQERE 1389 Query: 468 ESSLRQAASLR-EHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLA 526 L++ LR + +QL+ + +E QL++ + + REE QQ ++ E + Sbjct: 1390 RKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFL 1449 Query: 527 REQARVCELQSGNQQLEEQRVELVERLQ 554 E+ ++ + + + EEQ ++ E Q Sbjct: 1450 EEEQQLRQERHRKFREEEQLLQEREEQQ 1477 Score = 55.8 bits (133), Expect = 2e-07 Identities = 57/273 (20%), Positives = 117/273 (42%), Gaps = 18/273 (6%) Query: 297 ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE 356 ++ L + +R + + L R + E QR ++ + GQ + E R E Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAE 150 Query: 357 EERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWETQHQLALVQSEVR 413 E Q+ Q+ + ++ + +E + Q ERE+ +++ E + + E Sbjct: 151 GEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQL 210 Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473 R L+ R+ R+ Q Q R R+ E E + E R E + + +E L++ Sbjct: 211 RRRELLELRRKGREEKQ-----QQRRERQDRVFQEEE---EKEWRKRETVLRKEEEKLQE 262 Query: 474 AASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVC 533 R+ ++L + +Q + + + E E E++QQ++ + +LR +E+ R Sbjct: 263 EEPQRQ------RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER-R 315 Query: 534 ELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566 E Q ++ +E+R + ER + L+ +E + Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERRE 348 Score = 37.0 bits (84), Expect = 0.083 Identities = 48/178 (26%), Positives = 78/178 (43%), Gaps = 18/178 (10%) Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRK---KDTMIEQLDKTLARV 242 LR + E RR+ R I + E ++Q DRK ++ + ++ ++ R Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790 Query: 243 VEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL- 301 E + E E LR +EE Q R +Q++ R E+ E L E++ RL Sbjct: 1791 QESDRKFREE--EQLRQEREEQQL----RPQQRDGKYRWEE------EQLQLEEQEQRLR 1838 Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER 359 Q+R+R+ EE+ A + E+Q + QEE R + + RE R EE+R Sbjct: 1839 QERDRQYRAEEQFATQEKSRREEQE--LWQEEEQKRRQERERKLREEHIRRQQKEEQR 1894 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 104 bits (259), Expect = 4e-22 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256 R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011 Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311 R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++ Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071 Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2129 Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400 Q + + + AL+++ A E EK K +++AQ E Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189 Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447 T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+ Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498 E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309 Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556 ++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2367 Query: 557 LQA 559 L+A Sbjct: 2368 LEA 2370 Score = 103 bits (256), Expect = 9e-22 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%) Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1466 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297 L+ L+ + AE + + QE RL + + E + E E Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357 +AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+ Sbjct: 1527 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580 Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417 +R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R + Sbjct: 1581 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1635 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 + +AL+L + + + Q E+E + +R R +A+E ++RQ Sbjct: 1636 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690 Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 + KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A + Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1749 Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595 + Q+LE + ++ ++ +L + + ST S Q E E Sbjct: 1750 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1792 Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620 R + A L+ + ++++ R Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQR 1817 Score = 87.4 bits (215), Expect = 5e-17 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%) Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72 GAE++L E Q +L A+ ++ A A AQ D Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1150 Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128 EL + VG + L+++ G + + E+E R ++ +L+ + T R + G Sbjct: 1151 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207 Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185 + R A L + R Q+ P + +QA+ E + Q Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1253 Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239 L + ++ + + C+R + + + + QL VA+ KK + + + Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313 Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287 V+ H +E T E LR ++EE + AE R++++E + +E +L + Sbjct: 1314 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372 Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332 A E+E+ LQQR +E + +A ++A+QQ+ + +E Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1429 Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 + +AA +L E+ +R LE + E +L+ +A EE++AQ Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1488 Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441 + +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 +R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A Sbjct: 1549 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1604 Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561 Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA Sbjct: 1605 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1648 Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621 +E Q S + +E E+E RR AV + + +Q E + Sbjct: 1649 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698 Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655 +L G ++ +L L + Q + Q LE Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733 Score = 86.3 bits (212), Expect = 1e-16 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%) Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104 +RQAEA R++L + +E R + + LE +++ G++ E++++R Sbjct: 1437 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1480 Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 + + R + + + A+ + + QALEE Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219 L R + L + + R + T ++ E +QS + E QL Sbjct: 1541 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598 Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 VAVA A+R+ + E+ + R +E W + + E LR + + A+ Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1655 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315 Q E + E++ EA E+++ R ++ + LE++RQ Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715 Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 + LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + + Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1773 Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427 +E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ + Sbjct: 1774 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++ Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1882 Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ + Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942 Query: 548 EL 549 EL Sbjct: 1943 EL 1944 Score = 85.9 bits (211), Expect = 2e-16 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272 ELQ+ A A A R++ + E+L R + E L+ E A + R Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2258 Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K QE +++Q EA QE+ARL+Q E L ++R L+ + Q Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2317 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384 V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL Sbjct: 2318 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376 Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412 E R +E +QR + A E TQ ++ LVQ+ E+ Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470 +R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2495 Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510 L + SL + R +QL++ + QQ++ + + M E Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555 Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563 RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2614 Query: 564 --ANQLLST-TLP 573 A+Q+ +T TLP Sbjct: 2615 VTASQVAATKTLP 2627 Score = 67.4 bits (163), Expect = 6e-11 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%) Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265 Q+QLA AA R++ L + LA + E + EAE E LR L E+ Sbjct: 1816 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874 Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317 R + +E + + + E + L + +S +Q R+R +EEE AL Sbjct: 1875 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377 E A AG+ EL +R+ E+ ++ Q E + Q Sbjct: 1932 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977 Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429 EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L Sbjct: 1978 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036 Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2095 Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R Q + + Q Q E A +L Q E A+ + Q AE +E AR Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2148 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q E+ + + A ++ H A Q L Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178 Score = 67.4 bits (163), Expect = 6e-11 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E + K L E + +A ++ + E++ K + V+ R Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 +AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E + Sbjct: 2326 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2378 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365 E + L LR+ AE R EE DA R + +E + R L +E+ T Q Sbjct: 2379 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436 Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423 + Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + + Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496 Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556 Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 R+Q L+ Q ++ LA + + + ++ EE+ + E Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616 Query: 526 AREQARVCELQSGNQQLEEQRVE 548 A + A L +G L+ E Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAE 2639 Score = 39.7 bits (91), Expect = 0.013 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359 +E Q RLEA+ Q L + + R QL L T R EE+ Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922 Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409 + Q H L+ HYQA +SQ ERE Q ++ Q A + Sbjct: 923 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468 S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+ Sbjct: 980 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1033 Query: 469 SSL 471 L Sbjct: 1034 EGL 1036 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 104 bits (259), Expect = 4e-22 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256 R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV Sbjct: 1956 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2015 Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311 R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++ Sbjct: 2016 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2075 Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A Sbjct: 2076 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2133 Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400 Q + + + AL+++ A E EK K +++AQ E Sbjct: 2134 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2193 Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447 T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+ Sbjct: 2194 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2253 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498 E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA Sbjct: 2254 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2313 Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556 ++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q Sbjct: 2314 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2371 Query: 557 LQA 559 L+A Sbjct: 2372 LEA 2374 Score = 103 bits (256), Expect = 9e-22 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%) Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1470 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297 L+ L+ + AE + + QE RL + + E + E E Sbjct: 1471 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357 +AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+ Sbjct: 1531 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584 Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417 +R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R + Sbjct: 1585 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1639 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 + +AL+L + + + Q E+E + +R R +A+E ++RQ Sbjct: 1640 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1694 Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 + KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A + Sbjct: 1695 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1753 Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595 + Q+LE + ++ ++ +L + + ST S Q E E Sbjct: 1754 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1796 Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620 R + A L+ + ++++ R Sbjct: 1797 AGRFRELAEEAARLRALAEEAKRQR 1821 Score = 87.4 bits (215), Expect = 5e-17 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%) Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72 GAE++L E Q +L A+ ++ A A AQ D Sbjct: 1104 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1154 Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128 EL + VG + L+++ G + + E+E R ++ +L+ + T R + G Sbjct: 1155 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1211 Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185 + R A L + R Q+ P + +QA+ E + Q Sbjct: 1212 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1257 Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239 L + ++ + + C+R + + + + QL VA+ KK + + + Sbjct: 1258 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1317 Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287 V+ H +E T E LR ++EE + AE R++++E + +E +L + Sbjct: 1318 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1376 Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332 A E+E+ LQQR +E + +A ++A+QQ+ + +E Sbjct: 1377 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1433 Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 + +AA +L E+ +R LE + E +L+ +A EE++AQ Sbjct: 1434 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1492 Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441 + +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA Sbjct: 1493 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1552 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 +R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A Sbjct: 1553 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1608 Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561 Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA Sbjct: 1609 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1652 Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621 +E Q S + +E E+E RR AV + + +Q E + Sbjct: 1653 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1702 Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655 +L G ++ +L L + Q + Q LE Sbjct: 1703 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1737 Score = 86.3 bits (212), Expect = 1e-16 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%) Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104 +RQAEA R++L + +E R + + LE +++ G++ E++++R Sbjct: 1441 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1484 Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 + + R + + + A+ + + QALEE Sbjct: 1485 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1544 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219 L R + L + + R + T ++ E +QS + E QL Sbjct: 1545 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1602 Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 VAVA A+R+ + E+ + R +E W + + E LR + + A+ Sbjct: 1603 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1659 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315 Q E + E++ EA E+++ R ++ + LE++RQ Sbjct: 1660 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1719 Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 + LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + + Sbjct: 1720 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1777 Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427 +E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ + Sbjct: 1778 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1834 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++ Sbjct: 1835 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1886 Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ + Sbjct: 1887 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1946 Query: 548 EL 549 EL Sbjct: 1947 EL 1948 Score = 85.9 bits (211), Expect = 2e-16 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272 ELQ+ A A A R++ + E+L R + E L+ E A + R Sbjct: 2212 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2262 Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K QE +++Q EA QE+ARL+Q E L ++R L+ + Q Sbjct: 2263 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2321 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384 V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL Sbjct: 2322 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2380 Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412 E R +E +QR + A E TQ ++ LVQ+ E+ Sbjct: 2381 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470 +R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2499 Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510 L + SL + R +QL++ + QQ++ + + M E Sbjct: 2500 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2559 Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563 RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E Sbjct: 2560 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2618 Query: 564 --ANQLLST-TLP 573 A+Q+ +T TLP Sbjct: 2619 VTASQVAATKTLP 2631 Score = 67.4 bits (163), Expect = 6e-11 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%) Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265 Q+QLA AA R++ L + LA + E + EAE E LR L E+ Sbjct: 1820 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1878 Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317 R + +E + + + E + L + +S +Q R+R +EEE AL Sbjct: 1879 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1935 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377 E A AG+ EL +R+ E+ ++ Q E + Q Sbjct: 1936 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1981 Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429 EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L Sbjct: 1982 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2040 Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E Sbjct: 2041 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2099 Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R Q + + Q Q E A +L Q E A+ + Q AE +E AR Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2152 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q E+ + + A ++ H A Q L Sbjct: 2153 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2182 Score = 67.4 bits (163), Expect = 6e-11 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E + K L E + +A ++ + E++ K + V+ R Sbjct: 2270 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2329 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 +AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E + Sbjct: 2330 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2382 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365 E + L LR+ AE R EE DA R + +E + R L +E+ T Q Sbjct: 2383 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2440 Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423 + Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + + Sbjct: 2441 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2500 Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2560 Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 R+Q L+ Q ++ LA + + + ++ EE+ + E Sbjct: 2561 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2620 Query: 526 AREQARVCELQSGNQQLEEQRVE 548 A + A L +G L+ E Sbjct: 2621 ASQVAATKTLPNGRDALDGPAAE 2643 Score = 39.7 bits (91), Expect = 0.013 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359 +E Q RLEA+ Q L + + R QL L T R EE+ Sbjct: 867 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 926 Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409 + Q H L+ HYQA +SQ ERE Q ++ Q A + Sbjct: 927 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 983 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468 S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+ Sbjct: 984 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1037 Query: 469 SSL 471 L Sbjct: 1038 EGL 1040 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 104 bits (259), Expect = 4e-22 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256 R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV Sbjct: 1952 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2011 Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311 R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++ Sbjct: 2012 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2071 Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A Sbjct: 2072 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2129 Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400 Q + + + AL+++ A E EK K +++AQ E Sbjct: 2130 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2189 Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447 T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+ Sbjct: 2190 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2249 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498 E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA Sbjct: 2250 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2309 Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556 ++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q Sbjct: 2310 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2367 Query: 557 LQA 559 L+A Sbjct: 2368 LEA 2370 Score = 103 bits (256), Expect = 9e-22 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%) Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1466 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297 L+ L+ + AE + + QE RL + + E + E E Sbjct: 1467 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357 +AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+ Sbjct: 1527 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580 Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417 +R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R + Sbjct: 1581 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1635 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 + +AL+L + + + Q E+E + +R R +A+E ++RQ Sbjct: 1636 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1690 Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 + KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A + Sbjct: 1691 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1749 Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595 + Q+LE + ++ ++ +L + + ST S Q E E Sbjct: 1750 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1792 Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620 R + A L+ + ++++ R Sbjct: 1793 AGRFRELAEEAARLRALAEEAKRQR 1817 Score = 87.4 bits (215), Expect = 5e-17 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%) Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72 GAE++L E Q +L A+ ++ A A AQ D Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1150 Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128 EL + VG + L+++ G + + E+E R ++ +L+ + T R + G Sbjct: 1151 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1207 Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185 + R A L + R Q+ P + +QA+ E + Q Sbjct: 1208 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1253 Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239 L + ++ + + C+R + + + + QL VA+ KK + + + Sbjct: 1254 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1313 Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287 V+ H +E T E LR ++EE + AE R++++E + +E +L + Sbjct: 1314 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1372 Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332 A E+E+ LQQR +E + +A ++A+QQ+ + +E Sbjct: 1373 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1429 Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 + +AA +L E+ +R LE + E +L+ +A EE++AQ Sbjct: 1430 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1488 Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441 + +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA Sbjct: 1489 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1548 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 +R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A Sbjct: 1549 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1604 Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561 Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA Sbjct: 1605 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1648 Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621 +E Q S + +E E+E RR AV + + +Q E + Sbjct: 1649 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1698 Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655 +L G ++ +L L + Q + Q LE Sbjct: 1699 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1733 Score = 86.3 bits (212), Expect = 1e-16 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%) Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104 +RQAEA R++L + +E R + + LE +++ G++ E++++R Sbjct: 1437 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1480 Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 + + R + + + A+ + + QALEE Sbjct: 1481 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1540 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219 L R + L + + R + T ++ E +QS + E QL Sbjct: 1541 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1598 Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 VAVA A+R+ + E+ + R +E W + + E LR + + A+ Sbjct: 1599 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1655 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315 Q E + E++ EA E+++ R ++ + LE++RQ Sbjct: 1656 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1715 Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 + LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + + Sbjct: 1716 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1773 Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427 +E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ + Sbjct: 1774 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1830 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++ Sbjct: 1831 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1882 Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ + Sbjct: 1883 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1942 Query: 548 EL 549 EL Sbjct: 1943 EL 1944 Score = 85.9 bits (211), Expect = 2e-16 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272 ELQ+ A A A R++ + E+L R + E L+ E A + R Sbjct: 2208 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2258 Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K QE +++Q EA QE+ARL+Q E L ++R L+ + Q Sbjct: 2259 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2317 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384 V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL Sbjct: 2318 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376 Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412 E R +E +QR + A E TQ ++ LVQ+ E+ Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470 +R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2495 Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510 L + SL + R +QL++ + QQ++ + + M E Sbjct: 2496 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2555 Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563 RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E Sbjct: 2556 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2614 Query: 564 --ANQLLST-TLP 573 A+Q+ +T TLP Sbjct: 2615 VTASQVAATKTLP 2627 Score = 67.4 bits (163), Expect = 6e-11 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%) Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265 Q+QLA AA R++ L + LA + E + EAE E LR L E+ Sbjct: 1816 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1874 Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317 R + +E + + + E + L + +S +Q R+R +EEE AL Sbjct: 1875 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1931 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377 E A AG+ EL +R+ E+ ++ Q E + Q Sbjct: 1932 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1977 Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429 EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L Sbjct: 1978 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2036 Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E Sbjct: 2037 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2095 Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R Q + + Q Q E A +L Q E A+ + Q AE +E AR Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2148 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q E+ + + A ++ H A Q L Sbjct: 2149 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2178 Score = 67.4 bits (163), Expect = 6e-11 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E + K L E + +A ++ + E++ K + V+ R Sbjct: 2266 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2325 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 +AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E + Sbjct: 2326 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2378 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365 E + L LR+ AE R EE DA R + +E + R L +E+ T Q Sbjct: 2379 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436 Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423 + Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + + Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496 Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556 Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 R+Q L+ Q ++ LA + + + ++ EE+ + E Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616 Query: 526 AREQARVCELQSGNQQLEEQRVE 548 A + A L +G L+ E Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAE 2639 Score = 39.7 bits (91), Expect = 0.013 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359 +E Q RLEA+ Q L + + R QL L T R EE+ Sbjct: 863 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 922 Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409 + Q H L+ HYQA +SQ ERE Q ++ Q A + Sbjct: 923 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 979 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468 S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+ Sbjct: 980 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1033 Query: 469 SSL 471 L Sbjct: 1034 EGL 1036 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 104 bits (259), Expect = 4e-22 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256 R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV Sbjct: 1920 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1979 Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311 R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++ Sbjct: 1980 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2039 Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A Sbjct: 2040 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2097 Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400 Q + + + AL+++ A E EK K +++AQ E Sbjct: 2098 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2157 Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447 T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+ Sbjct: 2158 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2217 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498 E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA Sbjct: 2218 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2277 Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556 ++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q Sbjct: 2278 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2335 Query: 557 LQA 559 L+A Sbjct: 2336 LEA 2338 Score = 103 bits (256), Expect = 9e-22 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%) Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1434 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297 L+ L+ + AE + + QE RL + + E + E E Sbjct: 1435 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357 +AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+ Sbjct: 1495 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548 Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417 +R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R + Sbjct: 1549 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1603 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 + +AL+L + + + Q E+E + +R R +A+E ++RQ Sbjct: 1604 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1658 Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 + KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A + Sbjct: 1659 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1717 Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595 + Q+LE + ++ ++ +L + + ST S Q E E Sbjct: 1718 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1760 Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620 R + A L+ + ++++ R Sbjct: 1761 AGRFRELAEEAARLRALAEEAKRQR 1785 Score = 87.4 bits (215), Expect = 5e-17 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%) Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72 GAE++L E Q +L A+ ++ A A AQ D Sbjct: 1068 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1118 Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128 EL + VG + L+++ G + + E+E R ++ +L+ + T R + G Sbjct: 1119 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1175 Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185 + R A L + R Q+ P + +QA+ E + Q Sbjct: 1176 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1221 Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239 L + ++ + + C+R + + + + QL VA+ KK + + + Sbjct: 1222 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1281 Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287 V+ H +E T E LR ++EE + AE R++++E + +E +L + Sbjct: 1282 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1340 Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332 A E+E+ LQQR +E + +A ++A+QQ+ + +E Sbjct: 1341 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1397 Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 + +AA +L E+ +R LE + E +L+ +A EE++AQ Sbjct: 1398 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1456 Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441 + +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA Sbjct: 1457 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1516 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 +R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A Sbjct: 1517 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1572 Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561 Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA Sbjct: 1573 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1616 Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621 +E Q S + +E E+E RR AV + + +Q E + Sbjct: 1617 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1666 Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655 +L G ++ +L L + Q + Q LE Sbjct: 1667 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1701 Score = 86.3 bits (212), Expect = 1e-16 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%) Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104 +RQAEA R++L + +E R + + LE +++ G++ E++++R Sbjct: 1405 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1448 Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 + + R + + + A+ + + QALEE Sbjct: 1449 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1508 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219 L R + L + + R + T ++ E +QS + E QL Sbjct: 1509 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1566 Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 VAVA A+R+ + E+ + R +E W + + E LR + + A+ Sbjct: 1567 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1623 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315 Q E + E++ EA E+++ R ++ + LE++RQ Sbjct: 1624 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1683 Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 + LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + + Sbjct: 1684 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1741 Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427 +E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ + Sbjct: 1742 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1798 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++ Sbjct: 1799 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1850 Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ + Sbjct: 1851 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1910 Query: 548 EL 549 EL Sbjct: 1911 EL 1912 Score = 85.9 bits (211), Expect = 2e-16 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272 ELQ+ A A A R++ + E+L R + E L+ E A + R Sbjct: 2176 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2226 Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K QE +++Q EA QE+ARL+Q E L ++R L+ + Q Sbjct: 2227 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2285 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384 V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL Sbjct: 2286 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2344 Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412 E R +E +QR + A E TQ ++ LVQ+ E+ Sbjct: 2345 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470 +R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2463 Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510 L + SL + R +QL++ + QQ++ + + M E Sbjct: 2464 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2523 Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563 RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E Sbjct: 2524 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2582 Query: 564 --ANQLLST-TLP 573 A+Q+ +T TLP Sbjct: 2583 VTASQVAATKTLP 2595 Score = 67.4 bits (163), Expect = 6e-11 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%) Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265 Q+QLA AA R++ L + LA + E + EAE E LR L E+ Sbjct: 1784 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1842 Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317 R + +E + + + E + L + +S +Q R+R +EEE AL Sbjct: 1843 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1899 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377 E A AG+ EL +R+ E+ ++ Q E + Q Sbjct: 1900 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1945 Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429 EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L Sbjct: 1946 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2004 Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E Sbjct: 2005 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2063 Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R Q + + Q Q E A +L Q E A+ + Q AE +E AR Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2116 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q E+ + + A ++ H A Q L Sbjct: 2117 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2146 Score = 67.4 bits (163), Expect = 6e-11 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E + K L E + +A ++ + E++ K + V+ R Sbjct: 2234 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2293 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 +AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E + Sbjct: 2294 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2346 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365 E + L LR+ AE R EE DA R + +E + R L +E+ T Q Sbjct: 2347 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2404 Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423 + Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + + Sbjct: 2405 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2464 Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2524 Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 R+Q L+ Q ++ LA + + + ++ EE+ + E Sbjct: 2525 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2584 Query: 526 AREQARVCELQSGNQQLEEQRVE 548 A + A L +G L+ E Sbjct: 2585 ASQVAATKTLPNGRDALDGPAAE 2607 Score = 39.7 bits (91), Expect = 0.013 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359 +E Q RLEA+ Q L + + R QL L T R EE+ Sbjct: 831 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 890 Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409 + Q H L+ HYQA +SQ ERE Q ++ Q A + Sbjct: 891 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 947 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468 S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+ Sbjct: 948 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1001 Query: 469 SSL 471 L Sbjct: 1002 EGL 1004 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 104 bits (259), Expect = 4e-22 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256 R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV Sbjct: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2148 Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311 R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++ Sbjct: 2149 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208 Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A Sbjct: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2266 Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400 Q + + + AL+++ A E EK K +++AQ E Sbjct: 2267 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2326 Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447 T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+ Sbjct: 2327 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2386 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498 E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA Sbjct: 2387 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2446 Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556 ++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q Sbjct: 2447 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2504 Query: 557 LQA 559 L+A Sbjct: 2505 LEA 2507 Score = 103 bits (256), Expect = 9e-22 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%) Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1603 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297 L+ L+ + AE + + QE RL + + E + E E Sbjct: 1604 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357 +AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+ Sbjct: 1664 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717 Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417 +R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R + Sbjct: 1718 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1772 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 + +AL+L + + + Q E+E + +R R +A+E ++RQ Sbjct: 1773 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827 Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 + KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A + Sbjct: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1886 Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595 + Q+LE + ++ ++ +L + + ST S Q E E Sbjct: 1887 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1929 Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620 R + A L+ + ++++ R Sbjct: 1930 AGRFRELAEEAARLRALAEEAKRQR 1954 Score = 87.4 bits (215), Expect = 5e-17 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%) Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72 GAE++L E Q +L A+ ++ A A AQ D Sbjct: 1237 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1287 Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128 EL + VG + L+++ G + + E+E R ++ +L+ + T R + G Sbjct: 1288 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1344 Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185 + R A L + R Q+ P + +QA+ E + Q Sbjct: 1345 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1390 Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239 L + ++ + + C+R + + + + QL VA+ KK + + + Sbjct: 1391 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1450 Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287 V+ H +E T E LR ++EE + AE R++++E + +E +L + Sbjct: 1451 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1509 Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332 A E+E+ LQQR +E + +A ++A+QQ+ + +E Sbjct: 1510 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1566 Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 + +AA +L E+ +R LE + E +L+ +A EE++AQ Sbjct: 1567 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1625 Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441 + +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA Sbjct: 1626 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1685 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 +R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A Sbjct: 1686 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1741 Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561 Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA Sbjct: 1742 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1785 Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621 +E Q S + +E E+E RR AV + + +Q E + Sbjct: 1786 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835 Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655 +L G ++ +L L + Q + Q LE Sbjct: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870 Score = 86.3 bits (212), Expect = 1e-16 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%) Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104 +RQAEA R++L + +E R + + LE +++ G++ E++++R Sbjct: 1574 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1617 Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 + + R + + + A+ + + QALEE Sbjct: 1618 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219 L R + L + + R + T ++ E +QS + E QL Sbjct: 1678 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735 Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 VAVA A+R+ + E+ + R +E W + + E LR + + A+ Sbjct: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1792 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315 Q E + E++ EA E+++ R ++ + LE++RQ Sbjct: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852 Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 + LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + + Sbjct: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1910 Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427 +E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ + Sbjct: 1911 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1967 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++ Sbjct: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 2019 Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ + Sbjct: 2020 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 2079 Query: 548 EL 549 EL Sbjct: 2080 EL 2081 Score = 85.9 bits (211), Expect = 2e-16 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272 ELQ+ A A A R++ + E+L R + E L+ E A + R Sbjct: 2345 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2395 Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K QE +++Q EA QE+ARL+Q E L ++R L+ + Q Sbjct: 2396 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2454 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384 V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL Sbjct: 2455 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2513 Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412 E R +E +QR + A E TQ ++ LVQ+ E+ Sbjct: 2514 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470 +R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2632 Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510 L + SL + R +QL++ + QQ++ + + M E Sbjct: 2633 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2692 Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563 RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E Sbjct: 2693 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2751 Query: 564 --ANQLLST-TLP 573 A+Q+ +T TLP Sbjct: 2752 VTASQVAATKTLP 2764 Score = 67.4 bits (163), Expect = 6e-11 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%) Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265 Q+QLA AA R++ L + LA + E + EAE E LR L E+ Sbjct: 1953 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011 Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317 R + +E + + + E + L + +S +Q R+R +EEE AL Sbjct: 2012 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 2068 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377 E A AG+ EL +R+ E+ ++ Q E + Q Sbjct: 2069 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2114 Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429 EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L Sbjct: 2115 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173 Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E Sbjct: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2232 Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R Q + + Q Q E A +L Q E A+ + Q AE +E AR Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2285 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q E+ + + A ++ H A Q L Sbjct: 2286 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315 Score = 67.4 bits (163), Expect = 6e-11 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E + K L E + +A ++ + E++ K + V+ R Sbjct: 2403 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2462 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 +AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E + Sbjct: 2463 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2515 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365 E + L LR+ AE R EE DA R + +E + R L +E+ T Q Sbjct: 2516 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2573 Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423 + Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + + Sbjct: 2574 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633 Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2693 Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 R+Q L+ Q ++ LA + + + ++ EE+ + E Sbjct: 2694 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2753 Query: 526 AREQARVCELQSGNQQLEEQRVE 548 A + A L +G L+ E Sbjct: 2754 ASQVAATKTLPNGRDALDGPAAE 2776 Score = 39.7 bits (91), Expect = 0.013 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359 +E Q RLEA+ Q L + + R QL L T R EE+ Sbjct: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 1059 Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409 + Q H L+ HYQA +SQ ERE Q ++ Q A + Sbjct: 1060 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1116 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468 S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+ Sbjct: 1117 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1170 Query: 469 SSL 471 L Sbjct: 1171 EGL 1173 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 104 bits (259), Expect = 4e-22 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256 R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV Sbjct: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1989 Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311 R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++ Sbjct: 1990 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049 Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A Sbjct: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2107 Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400 Q + + + AL+++ A E EK K +++AQ E Sbjct: 2108 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2167 Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447 T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+ Sbjct: 2168 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2227 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498 E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA Sbjct: 2228 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2287 Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556 ++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q Sbjct: 2288 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2345 Query: 557 LQA 559 L+A Sbjct: 2346 LEA 2348 Score = 103 bits (256), Expect = 9e-22 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%) Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R Sbjct: 1386 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1444 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297 L+ L+ + AE + + QE RL + + E + E E Sbjct: 1445 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357 +AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+ Sbjct: 1505 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558 Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417 +R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R + Sbjct: 1559 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1613 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 + +AL+L + + + Q E+E + +R R +A+E ++RQ Sbjct: 1614 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668 Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 + KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A + Sbjct: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1727 Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595 + Q+LE + ++ ++ +L + + ST S Q E E Sbjct: 1728 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1770 Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620 R + A L+ + ++++ R Sbjct: 1771 AGRFRELAEEAARLRALAEEAKRQR 1795 Score = 87.4 bits (215), Expect = 5e-17 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%) Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72 GAE++L E Q +L A+ ++ A A AQ D Sbjct: 1078 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1128 Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128 EL + VG + L+++ G + + E+E R ++ +L+ + T R + G Sbjct: 1129 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1185 Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185 + R A L + R Q+ P + +QA+ E + Q Sbjct: 1186 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1231 Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239 L + ++ + + C+R + + + + QL VA+ KK + + + Sbjct: 1232 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1291 Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287 V+ H +E T E LR ++EE + AE R++++E + +E +L + Sbjct: 1292 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1350 Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332 A E+E+ LQQR +E + +A ++A+QQ+ + +E Sbjct: 1351 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1407 Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 + +AA +L E+ +R LE + E +L+ +A EE++AQ Sbjct: 1408 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1466 Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441 + +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA Sbjct: 1467 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1526 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 +R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A Sbjct: 1527 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1582 Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561 Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA Sbjct: 1583 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1626 Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621 +E Q S + +E E+E RR AV + + +Q E + Sbjct: 1627 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1676 Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655 +L G ++ +L L + Q + Q LE Sbjct: 1677 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711 Score = 86.3 bits (212), Expect = 1e-16 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%) Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104 +RQAEA R++L + +E R + + LE +++ G++ E++++R Sbjct: 1415 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1458 Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 + + R + + + A+ + + QALEE Sbjct: 1459 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219 L R + L + + R + T ++ E +QS + E QL Sbjct: 1519 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576 Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 VAVA A+R+ + E+ + R +E W + + E LR + + A+ Sbjct: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1633 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315 Q E + E++ EA E+++ R ++ + LE++RQ Sbjct: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693 Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 + LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + + Sbjct: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1751 Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427 +E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ + Sbjct: 1752 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++ Sbjct: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1860 Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ + Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920 Query: 548 EL 549 EL Sbjct: 1921 EL 1922 Score = 85.9 bits (211), Expect = 2e-16 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272 ELQ+ A A A R++ + E+L R + E L+ E A + R Sbjct: 2186 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2236 Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K QE +++Q EA QE+ARL+Q E L ++R L+ + Q Sbjct: 2237 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2295 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384 V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL Sbjct: 2296 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354 Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412 E R +E +QR + A E TQ ++ LVQ+ E+ Sbjct: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470 +R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2473 Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510 L + SL + R +QL++ + QQ++ + + M E Sbjct: 2474 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2533 Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563 RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E Sbjct: 2534 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2592 Query: 564 --ANQLLST-TLP 573 A+Q+ +T TLP Sbjct: 2593 VTASQVAATKTLP 2605 Score = 67.4 bits (163), Expect = 6e-11 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%) Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265 Q+QLA AA R++ L + LA + E + EAE E LR L E+ Sbjct: 1794 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852 Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317 R + +E + + + E + L + +S +Q R+R +EEE AL Sbjct: 1853 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1909 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377 E A AG+ EL +R+ E+ ++ Q E + Q Sbjct: 1910 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1955 Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429 EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L Sbjct: 1956 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2014 Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E Sbjct: 2015 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2073 Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R Q + + Q Q E A +L Q E A+ + Q AE +E AR Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2126 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q E+ + + A ++ H A Q L Sbjct: 2127 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156 Score = 67.4 bits (163), Expect = 6e-11 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E + K L E + +A ++ + E++ K + V+ R Sbjct: 2244 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2303 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 +AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E + Sbjct: 2304 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2356 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365 E + L LR+ AE R EE DA R + +E + R L +E+ T Q Sbjct: 2357 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414 Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423 + Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + + Sbjct: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474 Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534 Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 R+Q L+ Q ++ LA + + + ++ EE+ + E Sbjct: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594 Query: 526 AREQARVCELQSGNQQLEEQRVE 548 A + A L +G L+ E Sbjct: 2595 ASQVAATKTLPNGRDALDGPAAE 2617 Score = 39.7 bits (91), Expect = 0.013 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359 +E Q RLEA+ Q L + + R QL L T R EE+ Sbjct: 841 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900 Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409 + Q H L+ HYQA +SQ ERE Q ++ Q A + Sbjct: 901 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 957 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468 S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+ Sbjct: 958 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1011 Query: 469 SSL 471 L Sbjct: 1012 EGL 1014 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 104 bits (259), Expect = 4e-22 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256 R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV Sbjct: 1938 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 1997 Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311 R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++ Sbjct: 1998 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2057 Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A Sbjct: 2058 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2115 Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400 Q + + + AL+++ A E EK K +++AQ E Sbjct: 2116 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2175 Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447 T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+ Sbjct: 2176 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2235 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498 E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA Sbjct: 2236 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2295 Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556 ++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q Sbjct: 2296 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2353 Query: 557 LQA 559 L+A Sbjct: 2354 LEA 2356 Score = 103 bits (256), Expect = 9e-22 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%) Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1452 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297 L+ L+ + AE + + QE RL + + E + E E Sbjct: 1453 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357 +AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+ Sbjct: 1513 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566 Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417 +R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R + Sbjct: 1567 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1621 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 + +AL+L + + + Q E+E + +R R +A+E ++RQ Sbjct: 1622 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1676 Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 + KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A + Sbjct: 1677 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1735 Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595 + Q+LE + ++ ++ +L + + ST S Q E E Sbjct: 1736 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1778 Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620 R + A L+ + ++++ R Sbjct: 1779 AGRFRELAEEAARLRALAEEAKRQR 1803 Score = 87.4 bits (215), Expect = 5e-17 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%) Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72 GAE++L E Q +L A+ ++ A A AQ D Sbjct: 1086 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1136 Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128 EL + VG + L+++ G + + E+E R ++ +L+ + T R + G Sbjct: 1137 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1193 Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185 + R A L + R Q+ P + +QA+ E + Q Sbjct: 1194 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1239 Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239 L + ++ + + C+R + + + + QL VA+ KK + + + Sbjct: 1240 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1299 Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287 V+ H +E T E LR ++EE + AE R++++E + +E +L + Sbjct: 1300 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1358 Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332 A E+E+ LQQR +E + +A ++A+QQ+ + +E Sbjct: 1359 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1415 Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 + +AA +L E+ +R LE + E +L+ +A EE++AQ Sbjct: 1416 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1474 Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441 + +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA Sbjct: 1475 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1534 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 +R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A Sbjct: 1535 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1590 Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561 Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA Sbjct: 1591 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1634 Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621 +E Q S + +E E+E RR AV + + +Q E + Sbjct: 1635 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1684 Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655 +L G ++ +L L + Q + Q LE Sbjct: 1685 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1719 Score = 86.3 bits (212), Expect = 1e-16 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%) Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104 +RQAEA R++L + +E R + + LE +++ G++ E++++R Sbjct: 1423 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1466 Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 + + R + + + A+ + + QALEE Sbjct: 1467 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1526 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219 L R + L + + R + T ++ E +QS + E QL Sbjct: 1527 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1584 Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 VAVA A+R+ + E+ + R +E W + + E LR + + A+ Sbjct: 1585 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1641 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315 Q E + E++ EA E+++ R ++ + LE++RQ Sbjct: 1642 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1701 Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 + LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + + Sbjct: 1702 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1759 Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427 +E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ + Sbjct: 1760 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1816 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++ Sbjct: 1817 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1868 Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ + Sbjct: 1869 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1928 Query: 548 EL 549 EL Sbjct: 1929 EL 1930 Score = 85.9 bits (211), Expect = 2e-16 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272 ELQ+ A A A R++ + E+L R + E L+ E A + R Sbjct: 2194 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2244 Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K QE +++Q EA QE+ARL+Q E L ++R L+ + Q Sbjct: 2245 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2303 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384 V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL Sbjct: 2304 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362 Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412 E R +E +QR + A E TQ ++ LVQ+ E+ Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470 +R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2481 Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510 L + SL + R +QL++ + QQ++ + + M E Sbjct: 2482 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2541 Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563 RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E Sbjct: 2542 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2600 Query: 564 --ANQLLST-TLP 573 A+Q+ +T TLP Sbjct: 2601 VTASQVAATKTLP 2613 Score = 67.4 bits (163), Expect = 6e-11 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%) Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265 Q+QLA AA R++ L + LA + E + EAE E LR L E+ Sbjct: 1802 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1860 Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317 R + +E + + + E + L + +S +Q R+R +EEE AL Sbjct: 1861 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1917 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377 E A AG+ EL +R+ E+ ++ Q E + Q Sbjct: 1918 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 1963 Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429 EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L Sbjct: 1964 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2022 Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E Sbjct: 2023 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2081 Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R Q + + Q Q E A +L Q E A+ + Q AE +E AR Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2134 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q E+ + + A ++ H A Q L Sbjct: 2135 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2164 Score = 67.4 bits (163), Expect = 6e-11 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E + K L E + +A ++ + E++ K + V+ R Sbjct: 2252 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2311 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 +AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E + Sbjct: 2312 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2364 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365 E + L LR+ AE R EE DA R + +E + R L +E+ T Q Sbjct: 2365 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422 Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423 + Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + + Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482 Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542 Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 R+Q L+ Q ++ LA + + + ++ EE+ + E Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602 Query: 526 AREQARVCELQSGNQQLEEQRVE 548 A + A L +G L+ E Sbjct: 2603 ASQVAATKTLPNGRDALDGPAAE 2625 Score = 39.7 bits (91), Expect = 0.013 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359 +E Q RLEA+ Q L + + R QL L T R EE+ Sbjct: 849 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 908 Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409 + Q H L+ HYQA +SQ ERE Q ++ Q A + Sbjct: 909 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 965 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468 S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+ Sbjct: 966 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1019 Query: 469 SSL 471 L Sbjct: 1020 EGL 1022 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 104 bits (259), Expect = 4e-22 Identities = 109/423 (25%), Positives = 196/423 (46%), Gaps = 64/423 (15%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEV 256 R + E ++S + LE +Q +A +R++ E++ K+LA E + +A EV Sbjct: 1979 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV 2038 Query: 257 LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESAR--LQQRERE---TLEE 311 R + +A L +QE+ +L+ + A + L E+++ +QQ+E+E TL++ Sbjct: 2039 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2098 Query: 312 ERQALT-LRLEAEQQRCCV-------LQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E+ L LR EAE R +Q ER+AA++ + E E E L+ + EE+ Q A Sbjct: 2099 EQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVE--EAERLKQSAEEQAQARA 2156 Query: 364 QQE---------------HQLKEHYQALQEESQAQLEREKEKS------QREAQAAWE-- 400 Q + + + AL+++ A E EK K +++AQ E Sbjct: 2157 QAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT 2216 Query: 401 --------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE-----SQRIQL 447 T HQ L+ E++RL+ E A R+R ++ E+ V+ + E RI+ Sbjct: 2217 TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEA 2276 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAA------SLREHHRKQLQDLSGQ---HQQELAS 498 E+ + ++ T+R Q + ++Q A S+ +L+ L+ + Q+ LA Sbjct: 2277 ENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2336 Query: 499 QLAQFKVEMAEREERQQQVAE--DYELRLAREQARVCELQSGNQQLEEQRVELVERLQAM 556 ++ + K++ + R + AE + LA+EQAR LQ +Q+ +Q E + Q Sbjct: 2337 KMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLAEETQGFQRT 2394 Query: 557 LQA 559 L+A Sbjct: 2395 LEA 2397 Score = 103 bits (256), Expect = 9e-22 Identities = 108/445 (24%), Positives = 199/445 (44%), Gaps = 48/445 (10%) Query: 189 ALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNR 248 A+D++ +R E Q Q+ E+Q + A AA+R + IE+ + + +E R Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSR-LRIEEEIRVVRLQLEATER 1493 Query: 249 HEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-----------EAMEALNREQE 297 L+ L+ + AE + + QE RL + + E + E E Sbjct: 1494 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEE 357 +AR +QR + LEE LRL+AE+ + Q E + AR Q++ + A L+ Sbjct: 1554 AAREKQRALQALEE------LRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607 Query: 358 ERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEG 417 +R ++A++ QL+ ++LQEE A + + +E+++R AQ E + + E+ R + Sbjct: 1608 KRASFAEKTAQLE---RSLQEEHVA-VAQLREEAERRAQQQAEAERAREEAERELERWQ- 1662 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 + +AL+L + + + Q E+E + +R R +A+E ++RQ Sbjct: 1663 -----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1717 Query: 478 REHHRKQLQDLSGQHQQELAS--QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 + KQ Q G QQ LA+ +L + + E E+ E+Q+Q+ E+ RL RE A + Sbjct: 1718 EQELEKQRQLAEGTAQQRLAAEQELIRLRAE-TEQGEQQRQLLEEELARLQREAAAATQK 1776 Query: 536 QSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKE 595 + Q+LE + ++ ++ +L + + ST S Q E E Sbjct: 1777 R---QELEAELAKVRAEMEVLLASKARAEEESRST--------------SEKSKQRLEAE 1819 Query: 596 ERRVWTMPPMAVALKPVLQQSREAR 620 R + A L+ + ++++ R Sbjct: 1820 AGRFRELAEEAARLRALAEEAKRQR 1844 Score = 87.4 bits (215), Expect = 5e-17 Identities = 156/695 (22%), Positives = 282/695 (40%), Gaps = 113/695 (16%) Query: 13 GAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFA 72 GAE++L E Q +L A+ ++ A A AQ D Sbjct: 1127 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQ---------QPTFDALR 1177 Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSR----DTAYRDPLIPGAGS 128 EL + VG + L+++ G + + E+E R ++ +L+ + T R + G Sbjct: 1178 DELRGAQEVG--ERLQQRHGERDV-EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGR 1234 Query: 129 ERREEDSFDSDSTATLLNTRPLQD---LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQG 185 + R A L + R Q+ P + +QA+ E + Q Sbjct: 1235 QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQE--------------QA 1280 Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAV------AVAADRKKDTMIEQLDKTL 239 L + ++ + + C+R + + + + QL VA+ KK + + + Sbjct: 1281 LLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVI 1340 Query: 240 ARVVEGWNRHEAERT-----------EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSE- 287 V+ H +E T E LR ++EE + AE R++++E + +E +L + Sbjct: 1341 QEYVD-LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1399 Query: 288 -------AMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-------- 332 A E+E+ LQQR +E + +A ++A+QQ+ + +E Sbjct: 1400 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA---VDAQQQKRSIQEELQQLRQSS 1456 Query: 333 ---------ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 + +AA +L E+ +R LE + E +L+ +A EE++AQ Sbjct: 1457 EAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA-LRARAEEAEAQ 1515 Query: 384 LEREKEKSQR-EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQ-LEMSLVQARYE 441 + +E+++R Q E+Q + R++ E + AR ++ ALQ LE +QA Sbjct: 1516 KRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEA 1575 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 +R++ + V+ ++V L AQ S+ + S R ++ L Q+E + +A Sbjct: 1576 ERRLR---QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA-VA 1631 Query: 502 QFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHW 561 Q + E AER +QQ AE ARE+A ++LE +++ E L+ LQA Sbjct: 1632 QLR-EEAERRAQQQAEAE-----RAREEA--------ERELERWQLKANEALRLRLQA-- 1675 Query: 562 DEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARD 621 +E Q S + +E E+E RR AV + + +Q E + Sbjct: 1676 EEVAQQKSLA----------QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1725 Query: 622 EL-PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLE 655 +L G ++ +L L + Q + Q LE Sbjct: 1726 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1760 Score = 86.3 bits (212), Expect = 1e-16 Identities = 119/542 (21%), Positives = 231/542 (42%), Gaps = 71/542 (13%) Query: 45 SRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRG 104 +RQAEA R++L + +E R + + LE +++ G++ E++++R Sbjct: 1464 ARQAEAAERSRLRI--------------EEEIRVVRLQLEATERQRGGAEG--ELQALRA 1507 Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 + + R + + + A+ + + QALEE Sbjct: 1508 RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEE 1567 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLA----- 219 L R + L + + R + T ++ E +QS + E QL Sbjct: 1568 L--RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1625 Query: 220 --VAVA-----ADRK--KDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 VAVA A+R+ + E+ + R +E W + + E LR + + A+ Sbjct: 1626 EHVAVAQLREEAERRAQQQAEAERAREEAERELERW---QLKANEALRLRLQAEEVAQQK 1682 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA--------------- 315 Q E + E++ EA E+++ R ++ + LE++RQ Sbjct: 1683 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1742 Query: 316 LTLRLEAEQ--QRCCVLQEE-----RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ 368 + LR E EQ Q+ +L+EE R+AA A Q + +ELE A + E + + + Sbjct: 1743 IRLRAETEQGEQQRQLLEEELARLQREAAAATQ--KRQELEAELAKVRAEMEVLLASKAR 1800 Query: 369 LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLE-GELDTARRERD 427 +E ++ E+S+ +LE E + R + A E AL + R+ + E D AR+ + Sbjct: 1801 AEEESRSTSEKSKQRLEAE---AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1857 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 A ++ + A E+ R++ E+E+A++ ++ ERL + E Q R++L++ Sbjct: 1858 AERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ--------RRRLEE 1909 Query: 488 LSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + QH+ ++ +LAQ + ERQ+ + ED + + + + L++ ++ + Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969 Query: 548 EL 549 EL Sbjct: 1970 EL 1971 Score = 85.9 bits (211), Expect = 2e-16 Identities = 117/433 (27%), Positives = 186/433 (42%), Gaps = 85/433 (19%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRS 272 ELQ+ A A A R++ + E+L R + E L+ E A + R Sbjct: 2235 ELQRLKAEATEAARQRSQVEEELFSV---------RVQMEELSKLKARIEAENRALILRD 2285 Query: 273 KQ------QETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K QE +++Q EA QE+ARL+Q E L ++R L+ + Q Sbjct: 2286 KDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ- 2344 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAA-LEEERQTWAQQEHQLKEHYQ-ALQEESQAQL 384 V + R A A L + +EL +A L+E+++ AQQ + + +Q L+ E Q QL Sbjct: 2345 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2403 Query: 385 E--------------------REKEKSQREAQAAWE-----------TQHQLALVQS-EV 412 E R +E +QR + A E TQ ++ LVQ+ E+ Sbjct: 2404 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESE--LAVQLEQRVTERLAQAQESS 470 +R + + D R +LE + + E++ +QL+SE VQ EQ + E A Q+S Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQA-LQQSF 2522 Query: 471 LRQAASLREHHR--------------------KQLQDLSGQHQQELASQLAQFKVEMAER 510 L + SL + R +QL++ + QQ++ + + M E Sbjct: 2523 LSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEA 2582 Query: 511 EERQQQVAEDY-----ELRLAREQARVCE--LQSGNQQLEEQRVELVERLQAMLQAHWDE 563 RQ + E EL+ +Q R E L NQ+L EQ ++L+E AH +E Sbjct: 2583 RRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ-LQLLEEQHRAALAHSEE 2641 Query: 564 --ANQLLST-TLP 573 A+Q+ +T TLP Sbjct: 2642 VTASQVAATKTLP 2654 Score = 67.4 bits (163), Expect = 6e-11 Identities = 99/390 (25%), Positives = 156/390 (40%), Gaps = 63/390 (16%) Query: 215 QQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN-RHEAE--------RTEVLRGLQEEHQ 265 Q+QLA AA R++ L + LA + E + EAE E LR L E+ Sbjct: 1843 QRQLAEEDAA-RQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1901 Query: 266 AAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ--------RERETLEEERQALT 317 R + +E + + + E + L + +S +Q R+R +EEE AL Sbjct: 1902 ---FQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALK 1958 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ 377 E A AG+ EL +R+ E+ ++ Q E + Q Sbjct: 1959 ASFE--------------KAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAA 2004 Query: 378 EESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD--------AL 429 EE + + E E E+ Q+ A E Q EV RL+ +++ ARR R+ L Sbjct: 2005 EEERRRREAE-ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2063 Query: 430 QLEMSLVQARYES---------QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREH 480 QL Q R ++ Q+ + E + +Q EQ V ++L + + + R+AA E Sbjct: 2064 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQL-RGEAEAARRAAEEAEE 2122 Query: 481 HRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R Q + + Q Q E A +L Q E A+ + Q AE +E AR Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR------- 2175 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q E+ + + A ++ H A Q L Sbjct: 2176 RAQAEQAALRQKQAADAEMEKHKKFAEQTL 2205 Score = 67.4 bits (163), Expect = 6e-11 Identities = 91/383 (23%), Positives = 160/383 (41%), Gaps = 33/383 (8%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L E + K L E + +A ++ + E++ K + V+ R Sbjct: 2293 LQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRL 2352 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 +AE LQ++ + A+ + QE ++ Q L+E + R E+ R +Q E + Sbjct: 2353 KAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE---M 2405 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE-EERQTWAQQ--- 365 E + L LR+ AE R EE DA R + +E + R L +E+ T Q Sbjct: 2406 SAEAERLKLRV-AEMSRAQARAEE-DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2463 Query: 366 EHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE--VRRLEGELDTAR 423 + Q +H E+ A+LEREKEK Q+EA+ ++ VQ E ++ + + Sbjct: 2464 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2523 Query: 424 RERDAL-QLEMSLVQARYESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 E+D+L Q E + Q + + +++ Q E A QL + + Q ++ R AS+ E Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2583 Query: 482 RKQ----------------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 R+Q L+ Q ++ LA + + + ++ EE+ + E Sbjct: 2584 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2643 Query: 526 AREQARVCELQSGNQQLEEQRVE 548 A + A L +G L+ E Sbjct: 2644 ASQVAATKTLPNGRDALDGPAAE 2666 Score = 39.7 bits (91), Expect = 0.013 Identities = 51/183 (27%), Positives = 71/183 (38%), Gaps = 31/183 (16%) Query: 311 EERQALTLRLEAEQQRCCVLQEE-----------RDAARAGQLSEHRELETLRAALEEER 359 +E Q RLEA+ Q L + + R QL L T R EE+ Sbjct: 890 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 949 Query: 360 QTWAQQEHQLKEHYQALQEESQ----------AQLEREKEKSQREAQAAWETQHQLALVQ 409 + Q H L+ HYQA +SQ ERE Q ++ Q A + Sbjct: 950 R---QALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEE 1006 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTE-RLAQAQE 468 S +R EL R LQLE + + R+ L+ E A + QR+ E + AQA+ Sbjct: 1007 SRCQRCISELKDIR-----LQLEACETRTVHR-LRLPLDKEPARECAQRIAEQQKAQAEV 1060 Query: 469 SSL 471 L Sbjct: 1061 EGL 1063 >gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] Length = 2003 Score = 89.4 bits (220), Expect = 1e-17 Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%) Query: 27 LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82 L + + + QL A L +AE T A + L E G +E SR + Sbjct: 910 LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 968 Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141 +KK +HI E+E+ L+ + +R + + A ++ EED D Sbjct: 969 -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1019 Query: 142 ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200 + L R L +D S+QA EE + SL + D L E R+ Sbjct: 1020 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1078 Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257 E+ + L ELQ+Q+ V ++ + + QL + + R E E R ++L Sbjct: 1079 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1135 Query: 258 RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307 + L+E A AE + E V R + + L E +EAL E E S QQ R Sbjct: 1136 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1195 Query: 308 TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363 E+E L LE E + +QE +R G+L+E E + A E+ R Sbjct: 1196 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1255 Query: 364 QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413 + +L+ +LQ E+ + +LE + ++ Q A +A E +L Q+E+ Sbjct: 1256 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1315 Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473 + G L+ A + L E+S +A+ + L+ E +L R +A+ + LR+ Sbjct: 1316 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1375 Query: 474 A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523 A+ RE ++LQ Q Q+E A L + E R + AE Sbjct: 1376 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1431 Query: 524 RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577 RLA + V L+ G ++L+++ +E +L + L+ + +QLL Sbjct: 1432 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1482 Query: 578 PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623 A +E E+ E A++L L++ +EAR+EL Sbjct: 1483 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1527 Score = 86.7 bits (213), Expect = 9e-17 Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%) Query: 6 DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65 D SS L E ++ L +L A+L + E ARAQL L S Sbjct: 1086 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1142 Query: 66 EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124 L ++L + +++D + E+E++RG+L+ T+ T+ R Sbjct: 1143 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1195 Query: 125 GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178 +RE++ + T T ++ +Q+L QAL EL + R G Sbjct: 1196 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1249 Query: 179 ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234 + LR L S T R+ E+ + L+ ++ E+Q + A + +++ Sbjct: 1250 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1309 Query: 235 LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277 L V N E++ + + L H A EL TR+K + Sbjct: 1310 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1369 Query: 278 VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323 L + L E A E RE ++A+ Q E E EE R+ EA Sbjct: 1370 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1429 Query: 324 QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 QR E D G+ +EL+ LE++RQ + E + ++ Q L EE A Sbjct: 1430 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1489 Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436 L +E+ + EA+ L+L ++ E + R+ R AL+ E+ + Sbjct: 1490 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1548 Query: 437 -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486 ++ +E +R ++ + A L +VTE L A+++ LR +L+ H + LQ Sbjct: 1549 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1608 Query: 487 -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544 + + +++LA QL +VE ER++R VA +L E+ + +G Q +E Sbjct: 1609 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1666 Query: 545 QRVELVERLQAMLQAHWDEANQ 566 + V+ + ++QA ++ W E + Sbjct: 1667 EAVKQLRKMQAQMKELWREVEE 1688 Score = 84.0 bits (206), Expect = 6e-16 Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%) Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241 GLR+ L+ E R+ R +Q+ Q ++ E Q++ A A+ A E+ + AR Sbjct: 1372 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1424 Query: 242 VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286 E + AE+TE + R LQ+E A + +Q++ V+ LE+ Sbjct: 1425 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1484 Query: 287 ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322 E EA RE+E+ L +Q RE LE + +AL LEA Sbjct: 1485 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1544 Query: 323 ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360 E +R C + E+ Q++E + LE AL + ER Sbjct: 1545 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1604 Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397 + E + Q ++ A++ER++E+ QR Q Sbjct: 1605 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1664 Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453 E QL +Q++++ L E++ R R+ + + + R E++ ++L+ ELA Sbjct: 1665 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1724 Query: 454 -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508 Q +Q E + +L +AA L E ++QL+ GQ ++EL + + ++ + Sbjct: 1725 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1781 Query: 509 EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553 +R + E L+ E++ + +SG QQLE Q EL RL Sbjct: 1782 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1826 Score = 72.0 bits (175), Expect = 2e-12 Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%) Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188 ER E + + ++ A L TR L++ +A EEL + +LR + + L Sbjct: 1497 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1543 Query: 189 ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 + D S H + C E+ L+ +V EL+ +L A A + + ++ L R Sbjct: 1544 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1603 Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300 ++G + ER R L ++ + AE+ R ++ R +++L+ A + L E E + Sbjct: 1604 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1655 Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360 Q +EE +++A+ + EE +R S++RE E LE E Sbjct: 1656 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1713 Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417 LQEE A ++ Q + A E + A + E R+LEG Sbjct: 1714 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1761 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 L E + Q L+ RY +L +Q+E TE A+ S +A S Sbjct: 1762 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1811 Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522 R+ +Q+Q+L G+ +E A A+ K+ +A E + Q E E Sbjct: 1812 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1856 Score = 69.3 bits (168), Expect = 2e-11 Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%) Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 D QG RD E RR+ + ++ + E ++Q +AVAA +K + +E+L +A Sbjct: 1604 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1660 Query: 242 VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294 +G + +A+ E+ R ++E + E S+ +E+ RL+ +E + R Sbjct: 1661 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1716 Query: 295 EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352 QE R R +++R + + + +L+E+R R GQL E E E Sbjct: 1717 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1776 Query: 353 AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400 + L + R+ Q E E + A E + QLER+ ++ + +A A Sbjct: 1777 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1836 Query: 401 TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460 + +A ++S++ + E +L+ RER +S R +R++ E L V+ E+RV Sbjct: 1837 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1890 Query: 461 ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520 ++L E + L ++QL++ +E AS+ + + E + AE Sbjct: 1891 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1941 Query: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579 + + R L+ G + V V RL+ + A +EA + + P P P + Sbjct: 1942 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 1997 Query: 580 PPAGP 584 PPA P Sbjct: 1998 PPAHP 2002 Score = 55.8 bits (133), Expect = 2e-07 Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%) Query: 253 RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312 R + L+ +QE Q + + Q V +LE+ + E L E E + R L Sbjct: 882 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 941 Query: 313 RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369 +Q L L + + R + EE + +R Q + R ++ L A LE E A+Q+ QL Sbjct: 942 KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 996 Query: 370 K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425 + E EE LE + K +E + + + + +E L+ R + Sbjct: 997 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1056 Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485 +A +M + E R +LE +L++R+ ++ QE + Q + ++L Sbjct: 1057 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1106 Query: 486 QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545 + G+ ++EL + LA+ + E R + + + E + LA Q + + + E+Q Sbjct: 1107 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1165 Query: 546 RVELVERLQAM 556 R +L E L+A+ Sbjct: 1166 RRDLGEELEAL 1176 >gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] Length = 1995 Score = 89.4 bits (220), Expect = 1e-17 Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%) Query: 27 LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82 L + + + QL A L +AE T A + L E G +E SR + Sbjct: 902 LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 960 Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141 +KK +HI E+E+ L+ + +R + + A ++ EED D Sbjct: 961 -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1011 Query: 142 ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200 + L R L +D S+QA EE + SL + D L E R+ Sbjct: 1012 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1070 Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257 E+ + L ELQ+Q+ V ++ + + QL + + R E E R ++L Sbjct: 1071 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1127 Query: 258 RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307 + L+E A AE + E V R + + L E +EAL E E S QQ R Sbjct: 1128 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1187 Query: 308 TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363 E+E L LE E + +QE +R G+L+E E + A E+ R Sbjct: 1188 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1247 Query: 364 QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413 + +L+ +LQ E+ + +LE + ++ Q A +A E +L Q+E+ Sbjct: 1248 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1307 Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473 + G L+ A + L E+S +A+ + L+ E +L R +A+ + LR+ Sbjct: 1308 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1367 Query: 474 A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523 A+ RE ++LQ Q Q+E A L + E R + AE Sbjct: 1368 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1423 Query: 524 RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577 RLA + V L+ G ++L+++ +E +L + L+ + +QLL Sbjct: 1424 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1474 Query: 578 PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623 A +E E+ E A++L L++ +EAR+EL Sbjct: 1475 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1519 Score = 86.7 bits (213), Expect = 9e-17 Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%) Query: 6 DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65 D SS L E ++ L +L A+L + E ARAQL L S Sbjct: 1078 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1134 Query: 66 EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124 L ++L + +++D + E+E++RG+L+ T+ T+ R Sbjct: 1135 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1187 Query: 125 GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178 +RE++ + T T ++ +Q+L QAL EL + R G Sbjct: 1188 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1241 Query: 179 ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234 + LR L S T R+ E+ + L+ ++ E+Q + A + +++ Sbjct: 1242 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1301 Query: 235 LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277 L V N E++ + + L H A EL TR+K + Sbjct: 1302 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1361 Query: 278 VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323 L + L E A E RE ++A+ Q E E EE R+ EA Sbjct: 1362 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1421 Query: 324 QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 QR E D G+ +EL+ LE++RQ + E + ++ Q L EE A Sbjct: 1422 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1481 Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436 L +E+ + EA+ L+L ++ E + R+ R AL+ E+ + Sbjct: 1482 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1540 Query: 437 -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486 ++ +E +R ++ + A L +VTE L A+++ LR +L+ H + LQ Sbjct: 1541 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1600 Query: 487 -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544 + + +++LA QL +VE ER++R VA +L E+ + +G Q +E Sbjct: 1601 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1658 Query: 545 QRVELVERLQAMLQAHWDEANQ 566 + V+ + ++QA ++ W E + Sbjct: 1659 EAVKQLRKMQAQMKELWREVEE 1680 Score = 84.0 bits (206), Expect = 6e-16 Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%) Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241 GLR+ L+ E R+ R +Q+ Q ++ E Q++ A A+ A E+ + AR Sbjct: 1364 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1416 Query: 242 VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286 E + AE+TE + R LQ+E A + +Q++ V+ LE+ Sbjct: 1417 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1476 Query: 287 ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322 E EA RE+E+ L +Q RE LE + +AL LEA Sbjct: 1477 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1536 Query: 323 ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360 E +R C + E+ Q++E + LE AL + ER Sbjct: 1537 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1596 Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397 + E + Q ++ A++ER++E+ QR Q Sbjct: 1597 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1656 Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453 E QL +Q++++ L E++ R R+ + + + R E++ ++L+ ELA Sbjct: 1657 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1716 Query: 454 -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508 Q +Q E + +L +AA L E ++QL+ GQ ++EL + + ++ + Sbjct: 1717 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1773 Query: 509 EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553 +R + E L+ E++ + +SG QQLE Q EL RL Sbjct: 1774 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1818 Score = 72.0 bits (175), Expect = 2e-12 Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%) Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188 ER E + + ++ A L TR L++ +A EEL + +LR + + L Sbjct: 1489 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1535 Query: 189 ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 + D S H + C E+ L+ +V EL+ +L A A + + ++ L R Sbjct: 1536 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1595 Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300 ++G + ER R L ++ + AE+ R ++ R +++L+ A + L E E + Sbjct: 1596 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1647 Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360 Q +EE +++A+ + EE +R S++RE E LE E Sbjct: 1648 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1705 Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417 LQEE A ++ Q + A E + A + E R+LEG Sbjct: 1706 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1753 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 L E + Q L+ RY +L +Q+E TE A+ S +A S Sbjct: 1754 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1803 Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522 R+ +Q+Q+L G+ +E A A+ K+ +A E + Q E E Sbjct: 1804 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1848 Score = 69.3 bits (168), Expect = 2e-11 Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%) Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 D QG RD E RR+ + ++ + E ++Q +AVAA +K + +E+L +A Sbjct: 1596 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1652 Query: 242 VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294 +G + +A+ E+ R ++E + E S+ +E+ RL+ +E + R Sbjct: 1653 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1708 Query: 295 EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352 QE R R +++R + + + +L+E+R R GQL E E E Sbjct: 1709 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1768 Query: 353 AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400 + L + R+ Q E E + A E + QLER+ ++ + +A A Sbjct: 1769 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1828 Query: 401 TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460 + +A ++S++ + E +L+ RER +S R +R++ E L V+ E+RV Sbjct: 1829 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1882 Query: 461 ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520 ++L E + L ++QL++ +E AS+ + + E + AE Sbjct: 1883 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1933 Query: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579 + + R L+ G + V V RL+ + A +EA + + P P P + Sbjct: 1934 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 1989 Query: 580 PPAGP 584 PPA P Sbjct: 1990 PPAHP 1994 Score = 55.8 bits (133), Expect = 2e-07 Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%) Query: 253 RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312 R + L+ +QE Q + + Q V +LE+ + E L E E + R L Sbjct: 874 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 933 Query: 313 RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369 +Q L L + + R + EE + +R Q + R ++ L A LE E A+Q+ QL Sbjct: 934 KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 988 Query: 370 K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425 + E EE LE + K +E + + + + +E L+ R + Sbjct: 989 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1048 Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485 +A +M + E R +LE +L++R+ ++ QE + Q + ++L Sbjct: 1049 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1098 Query: 486 QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545 + G+ ++EL + LA+ + E R + + + E + LA Q + + + E+Q Sbjct: 1099 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1157 Query: 546 RVELVERLQAM 556 R +L E L+A+ Sbjct: 1158 RRDLGEELEAL 1168 >gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] Length = 2036 Score = 89.4 bits (220), Expect = 1e-17 Identities = 158/646 (24%), Positives = 262/646 (40%), Gaps = 77/646 (11%) Query: 27 LNQVSSEVTSQLYASLRLSRQAEAT----ARAQLYLPSTSPPHEGLDGFAQELSRSLSVG 82 L + + + QL A L +AE T A + L E G +E SR + Sbjct: 943 LEEERARLAEQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQT- 1001 Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFD-SDST 141 +KK +HI E+E+ L+ + +R + + A ++ EED D Sbjct: 1002 -----EKKRLQQHIQELEA---HLEAE-EGARQKLQLEKVTTEAKMKKFEEDLLLLEDQN 1052 Query: 142 ATLLNTRPL-QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200 + L R L +D S+QA EE + SL + D L E R+ Sbjct: 1053 SKLSKERKLLEDRLAEFSSQAAEEE-EKVKSLNKLRLKYEATIADMEDRLRKEEKGRQEL 1111 Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE---RTEVL 257 E+ + L ELQ+Q+ V ++ + + QL + + R E E R ++L Sbjct: 1112 EKLKRRLDGESSELQEQM---VEQQQRAEELRAQLGRKEEELQAALARAEDEGGARAQLL 1168 Query: 258 RGLQEEHQA-AELTRSKQQETVTRLE-----QSLSEAMEALNREQE----SARLQQRERE 307 + L+E A AE + E V R + + L E +EAL E E S QQ R Sbjct: 1169 KSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQELRS 1228 Query: 308 TLEEERQALTLRLEAEQQ-RCCVLQE--ERDAARAGQLSEHRELETL-RAALEEERQTWA 363 E+E L LE E + +QE +R G+L+E E + A E+ R Sbjct: 1229 KREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAWEKTRLALE 1288 Query: 364 QQEHQLKEHYQALQ------EESQAQLEREKEKSQREA----QAAWETQHQLALVQSEVR 413 + +L+ +LQ E+ + +LE + ++ Q A +A E +L Q+E+ Sbjct: 1289 AEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELE 1348 Query: 414 RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQ 473 + G L+ A + L E+S +A+ + L+ E +L R +A+ + LR+ Sbjct: 1349 NVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLRE 1408 Query: 474 A----ASLREHHRKQLQDLSGQ------HQQELASQLAQFKVEMAEREERQQQVAEDYEL 523 A+ RE ++LQ Q Q+E A L + E R + AE Sbjct: 1409 QLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGE----EARRRAAREAEALTQ 1464 Query: 524 RLAREQARVCELQSGNQQLEEQR------VELVERLQAMLQAHWDEANQLLSTTLPPPNP 577 RLA + V L+ G ++L+++ +E +L + L+ + +QLL Sbjct: 1465 RLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLL--------- 1515 Query: 578 PAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623 A +E E+ E A++L L++ +EAR+EL Sbjct: 1516 -AEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREEL 1560 Score = 86.7 bits (213), Expect = 9e-17 Identities = 145/622 (23%), Positives = 253/622 (40%), Gaps = 80/622 (12%) Query: 6 DSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPH 65 D SS L E ++ L +L A+L + E ARAQL L S Sbjct: 1119 DGESSEL-QEQMVEQQQRAEELRAQLGRKEEELQAALARAED-EGGARAQL-LKSLREAQ 1175 Query: 66 EGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQ-TMLQTSRDTAYRDPLIP 124 L ++L + +++D + E+E++RG+L+ T+ T+ R Sbjct: 1176 AALAEAQEDLESERVARTKAEKQRRDLGE---ELEALRGELEDTLDSTNAQQELRS---- 1228 Query: 125 GAGSERREEDSFDSDSTA---TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPL--- 178 +RE++ + T T ++ +Q+L QAL EL + R G Sbjct: 1229 -----KREQEVTELKKTLEEETRIHEAAVQELR-QRHGQALGELAEQLEQARRGKGAWEK 1282 Query: 179 ----NPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ 234 + LR L S T R+ E+ + L+ ++ E+Q + A + +++ Sbjct: 1283 TRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKLQR 1342 Query: 235 LDKTLARVVEGWNRHEAERTEVLRGLQEE----HQAAEL----TRSK---------QQET 277 L V N E++ + + L H A EL TR+K + Sbjct: 1343 AQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAE 1402 Query: 278 VTRLEQSLSE---AMEALNREQESARLQQRE-----------RETLEEERQALTLRLEAE 323 L + L E A E RE ++A+ Q E E EE R+ EA Sbjct: 1403 AAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAGEEARRRAAREAEAL 1462 Query: 324 QQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQ 383 QR E D G+ +EL+ LE++RQ + E + ++ Q L EE A Sbjct: 1463 TQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAV 1522 Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLV------- 436 L +E+ + EA+ L+L ++ E + R+ R AL+ E+ + Sbjct: 1523 LRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNR-ALRAELEALLSSKDDV 1581 Query: 437 -QARYESQR-IQLESELAVQLEQRVTE---RLAQAQESSLR---QAASLREHHRKQLQ-- 486 ++ +E +R ++ + A L +VTE L A+++ LR +L+ H + LQ Sbjct: 1582 GKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGR 1641 Query: 487 -DLSGQHQQELASQLAQFKVEM-AEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544 + + +++LA QL +VE ER++R VA +L E+ + +G Q +E Sbjct: 1642 DEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAG--QGKE 1699 Query: 545 QRVELVERLQAMLQAHWDEANQ 566 + V+ + ++QA ++ W E + Sbjct: 1700 EAVKQLRKMQAQMKELWREVEE 1721 Score = 84.0 bits (206), Expect = 6e-16 Identities = 112/465 (24%), Positives = 192/465 (41%), Gaps = 106/465 (22%) Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLEL---QQQLAVAVAADRKKDTMIEQLDKTLAR 241 GLR+ L+ E R+ R +Q+ Q ++ E Q++ A A+ A E+ + AR Sbjct: 1405 GLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAGALEAG-------EEARRRAAR 1457 Query: 242 VVEGWNRHEAERTEVL-------RGLQEEHQAAELTRSKQQETVTRLEQSLS-------- 286 E + AE+TE + R LQ+E A + +Q++ V+ LE+ Sbjct: 1458 EAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAE 1517 Query: 287 ------------EAMEALNREQESARL--------QQRERETLEEERQALTLRLEA---- 322 E EA RE+E+ L +Q RE LE + +AL LEA Sbjct: 1518 EKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1577 Query: 323 ---------EQQRCCVLQEERDAARAGQLSEHRE-----------LETLRAAL--EEERQ 360 E +R C + E+ Q++E + LE AL + ER Sbjct: 1578 KDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERD 1637 Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQRE-----------------------AQA 397 + E + Q ++ A++ER++E+ QR Q Sbjct: 1638 LQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQG 1697 Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY---ESQRIQLESELAV- 453 E QL +Q++++ L E++ R R+ + + + R E++ ++L+ ELA Sbjct: 1698 KEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEELAAS 1757 Query: 454 -----QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA 508 Q +Q E + +L +AA L E ++QL+ GQ ++EL + + ++ + Sbjct: 1758 DRARRQAQQDRDEMADEVANGNLSKAAILEE--KRQLEGRLGQLEEELEEEQSNSEL-LN 1814 Query: 509 EREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERL 553 +R + E L+ E++ + +SG QQLE Q EL RL Sbjct: 1815 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRL 1859 Score = 72.0 bits (175), Expect = 2e-12 Identities = 100/405 (24%), Positives = 169/405 (41%), Gaps = 56/405 (13%) Query: 129 ERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRD 188 ER E + + ++ A L TR L++ +A EEL + +LR + + L Sbjct: 1530 ERAEAEGREREARALSL-TRALEE-----EQEAREELERQNRALRA-------ELEALLS 1576 Query: 189 ALD----SEHTRRKHC---ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 + D S H + C E+ L+ +V EL+ +L A A + + ++ L R Sbjct: 1577 SKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHER 1636 Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS-EAMEALNREQESAR 300 ++G + ER R L ++ + AE+ R ++ R +++L+ A + L E E + Sbjct: 1637 DLQGRDEAGEERR---RQLAKQLRDAEVERDEE-----RKQRTLAVAARKKLEGELEELK 1688 Query: 301 LQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ 360 Q +EE +++A+ + EE +R S++RE E LE E Sbjct: 1689 AQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAE-- 1746 Query: 361 TWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH---QLALVQSEVRRLEG 417 LQEE A ++ Q + A E + A + E R+LEG Sbjct: 1747 ------------VLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEG 1794 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 L E + Q L+ RY +L +Q+E TE A+ S +A S Sbjct: 1795 RLGQLEEELEEEQSNSELLNDRYR--------KLLLQVESLTTE--LSAERSFSAKAESG 1844 Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522 R+ +Q+Q+L G+ +E A A+ K+ +A E + Q E E Sbjct: 1845 RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQLE 1889 Score = 69.3 bits (168), Expect = 2e-11 Identities = 102/425 (24%), Positives = 185/425 (43%), Gaps = 48/425 (11%) Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 D QG RD E RR+ + ++ + E ++Q +AVAA +K + +E+L +A Sbjct: 1637 DLQG-RDEAGEE--RRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMAS 1693 Query: 242 VVEG-------WNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR 294 +G + +A+ E+ R ++E + E S+ +E+ RL+ +E + R Sbjct: 1694 AGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVL----R 1749 Query: 295 EQESARLQQRERETLEEERQALTLRL-EAEQQRCCVLQEERDA-ARAGQLSEHRELETLR 352 QE R R +++R + + + +L+E+R R GQL E E E Sbjct: 1750 LQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSN 1809 Query: 353 AAL--EEERQTWAQQEHQLKE-----HYQALQEESQAQLEREKEK-----SQREAQAAWE 400 + L + R+ Q E E + A E + QLER+ ++ + +A A Sbjct: 1810 SELLNDRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELRGRLGEEDAGARAR 1869 Query: 401 TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVT 460 + +A ++S++ + E +L+ RER +S R +R++ E L V+ E+RV Sbjct: 1870 HKMTIAALESKLAQAEEQLEQETRER-----ILSGKLVRRAEKRLK-EVVLQVEEERRVA 1923 Query: 461 ERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520 ++L E + L ++QL++ +E AS+ + + E + AE Sbjct: 1924 DQLRDQLEKGNLRVKQL----KRQLEE-----AEEEASRAQAGRRRLQRELEDVTESAES 1974 Query: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPP-A 579 + + R L+ G + V V RL+ + A +EA + + P P P + Sbjct: 1975 MNREVTTLRNR---LRRGPLTFTTRTVRQVFRLEEGV-ASDEEAEEAQPGSGPSPEPEGS 2030 Query: 580 PPAGP 584 PPA P Sbjct: 2031 PPAHP 2035 Score = 55.8 bits (133), Expect = 2e-07 Identities = 73/311 (23%), Positives = 135/311 (43%), Gaps = 23/311 (7%) Query: 253 RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEE 312 R + L+ +QE Q + + Q V +LE+ + E L E E + R L Sbjct: 915 RAQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR 974 Query: 313 RQALTLRLEAEQQRCCVLQEERDAARAGQLSEHR---ELETLRAALEEERQTWAQQEHQL 369 +Q L L + + R + EE + +R Q + R ++ L A LE E A+Q+ QL Sbjct: 975 KQELELVVSELEAR---VGEEEECSRQMQTEKKRLQQHIQELEAHLEAEE--GARQKLQL 1029 Query: 370 K----EHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRE 425 + E EE LE + K +E + + + + +E L+ R + Sbjct: 1030 EKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLK 1089 Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485 +A +M + E R +LE +L++R+ ++ QE + Q + ++L Sbjct: 1090 YEATIADMEDRLRKEEKGRQELE-----KLKRRLDGESSELQEQMVEQ-----QQRAEEL 1139 Query: 486 QDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQ 545 + G+ ++EL + LA+ + E R + + + E + LA Q + + + E+Q Sbjct: 1140 RAQLGRKEEELQAALARAEDEGGARAQLLKSLRE-AQAALAEAQEDLESERVARTKAEKQ 1198 Query: 546 RVELVERLQAM 556 R +L E L+A+ Sbjct: 1199 RRDLGEELEAL 1209 >gi|111955084 5-azacytidine induced 1 isoform a [Homo sapiens] Length = 1080 Score = 88.2 bits (217), Expect = 3e-17 Identities = 134/562 (23%), Positives = 228/562 (40%), Gaps = 72/562 (12%) Query: 25 PGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGF-AQELSRSLSVGL 83 PG ++ SEV++ + +RL + E +A L L L +E ++LS L Sbjct: 557 PGPLELGSEVSTSV---MRLKLEVEEKKQAMLLLQRALAQQRDLTARRVKETEKALSRQL 613 Query: 84 EKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTAT 143 ++ + + + ++ L + Q D +E ++ED ++ A Sbjct: 614 QRQREHYEAT--------IQRHLAFIDQLIEDKKVLSEKCEAVVAELKQEDQRCTERVAQ 665 Query: 144 L-----LNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRK 198 L + L++L ++ E+ T + +GL + R K Sbjct: 666 AQAQHELEIKKLKELMSATEKARREKWISEKTK-----KIKEVTVRGLEPEIQKLIARHK 720 Query: 199 HCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR 258 R ++SL L LQ + R+ + + EQL++ + G E R + Sbjct: 721 QEVRRLKSLHEAEL-LQSDERASQRCLRQAEELREQLEREKEAL--GQQERERARQRFQQ 777 Query: 259 GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRE-RETLEEERQALT 317 L++E A + R RL ++E E L ++ R + E R+ LEE ALT Sbjct: 778 HLEQEQWALQQQRQ-------RLYSEVAEERERLGQQAARQRAELEELRQQLEESSSALT 830 Query: 318 LRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA-----QQEHQLKEH 372 L AE ++ QE R EL TL+ LE ERQ W ++E L Sbjct: 831 RALRAEFEKGREEQERR---------HQMELNTLKQQLELERQAWEAGRTRKEEAWLLNR 881 Query: 373 YQALQEESQAQLEREKEK--SQREAQAAWETQHQLALVQSEVRRL----EGELDTARRER 426 Q L+EE + ++E E + EA A + +S ++RL E EL + Sbjct: 882 EQELREEIRKGRDKEIELVIHRLEADMALAKEESEKAAESRIKRLRDKYEAELSELEQSE 941 Query: 427 DALQ-----LEMSLVQARYESQRIQ---LESELAVQLEQRVTERLAQAQESSLRQAASLR 478 LQ L+ L +A E+ R+Q + E A++ Q V E+L+ ++ S+L Q Sbjct: 942 RKLQERCSELKGQLGEAEGENLRLQGLVRQKERALEDAQAVNEQLS-SERSNLAQVI--- 997 Query: 479 EHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R++ +D ++E Q K E+A + RQQ E+ R+ AR E S Sbjct: 998 ---RQEFEDRLAASEEETR----QAKAELATLQARQQLELEEVHRRVKTALARKEEAVSS 1050 Query: 539 NQQLEEQRVELVERLQAMLQAH 560 + E V+ + L+ +L+ H Sbjct: 1051 LRTQHEAAVKRADHLEELLEQH 1072 Score = 72.0 bits (175), Expect = 2e-12 Identities = 89/332 (26%), Positives = 152/332 (45%), Gaps = 46/332 (13%) Query: 269 LTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET---LEEERQALTLRLEAEQQ 325 L+ +K Q ++ L++ + L+ +QE + E + L+LE E++ Sbjct: 521 LSEAKLQSIMSFLDEMEKSGQDQLDSQQEGWVPEAGPGPLELGSEVSTSVMRLKLEVEEK 580 Query: 326 RCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEH-------------QLKEH 372 + +L +R A+ L+ R ET +A RQ Q+EH QL E Sbjct: 581 KQAMLLLQRALAQQRDLTARRVKETEKAL---SRQLQRQREHYEATIQRHLAFIDQLIED 637 Query: 373 YQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER------ 426 + L E+ +A + K++ QR + + Q Q L +++ L + ARRE+ Sbjct: 638 KKVLSEKCEAVVAELKQEDQRCTERVAQAQAQHELEIKKLKELMSATEKARREKWISEKT 697 Query: 427 --------DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR 478 L+ E+ + AR++ + +L+S +L Q ER A + LRQA LR Sbjct: 698 KKIKEVTVRGLEPEIQKLIARHKQEVRRLKSLHEAELLQS-DER---ASQRCLRQAEELR 753 Query: 479 EHHRKQLQDLSGQHQQELASQLAQFKVEMAE---REERQQ---QVAEDYELRLAREQARV 532 E ++ + L GQ ++E A Q Q +E + +++RQ+ +VAE+ E RL ++ AR Sbjct: 754 EQLEREKEAL-GQQERERARQRFQQHLEQEQWALQQQRQRLYSEVAEERE-RLGQQAARQ 811 Query: 533 -CELQSGNQQLEEQRVELVERLQAMLQAHWDE 563 EL+ QQLEE L L+A + +E Sbjct: 812 RAELEELRQQLEESSSALTRALRAEFEKGREE 843 Score = 33.1 bits (74), Expect = 1.2 Identities = 93/403 (23%), Positives = 146/403 (36%), Gaps = 96/403 (23%) Query: 384 LEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQ 443 L R KE ++ EA+ +Q + R + + RR A +LE L+QA+ E Q Sbjct: 250 LPRRKEVTEEEAERFIHQVNQATVTIQRWYRHQVQ----RRGAGAARLE-HLLQAKREEQ 304 Query: 444 RIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQF 503 R + + L Q+ +A+E RQA R +Q+L Q ++ L +Q Sbjct: 305 RQRSGEGTLLDLHQQKEAARRKAREEKARQA------RRAAIQEL--QQKRALRAQ---- 352 Query: 504 KVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDE 563 K AER + + RV ++ Q+L + L+A+ Sbjct: 353 KASTAERGPPENP-----------RETRVPGMRQPAQELSPTPGGTAHQA---LKAN--- 395 Query: 564 ANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDEL 623 N P P SSP PQ+P ++ + VL Q A D L Sbjct: 396 -NTGGGLPAAGPGDRCLPTSDSSPEPQQPPEDR------------TQDVLAQD-AAGDNL 441 Query: 624 PGAPPVLCSSSSDLSLLLGPSFQSQHSFQPLEPKPD------------------------ 659 P S+ S GP + H+ Q LE +PD Sbjct: 442 EMMAPSRGSAKS-----RGPLEELLHTLQLLEKEPDVLPRPRTHHRGRYAWASEEDDASS 496 Query: 660 LTSSTAGAFSALGAFHPDHRAERPFPEEDPGPDGEGLLKQGLPPAQLEGLKNFLHQLLET 719 LT+ F L AF P P +G L L A+L+ + +FL ++ ++ Sbjct: 497 LTADNLEKFGKLSAF--------------PEPPEDGTL---LSEAKLQSIMSFLDEMEKS 539 Query: 720 VPQNNENPSVDLLPPKS-GPLTVPSWEEAPQVPRIPPPVHKTK 761 ++ +P GPL + S E + V R+ V + K Sbjct: 540 GQDQLDSQQEGWVPEAGPGPLELGS-EVSTSVMRLKLEVEEKK 581 >gi|16262452 cingulin [Homo sapiens] Length = 1203 Score = 87.4 bits (215), Expect = 5e-17 Identities = 119/442 (26%), Positives = 195/442 (44%), Gaps = 82/442 (18%) Query: 193 EHTRRKHCERHIQSL--QTRVLELQQQLAVA-VAADRKKDTMIE--QLDKTLARVVEGWN 247 E + ER Q + + R EL++QLAV V ADR ++ + QL KTL ++ + + Sbjct: 639 EELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQ--D 696 Query: 248 RHEAERTEVLRG-----LQEEHQAAELTRSKQQET-------VTRLEQSLSE-------- 287 EA + +++ L + A E T + QE + LEQ L E Sbjct: 697 CEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRILGLEQQLKETRGLVDGG 756 Query: 288 -AMEALNRE------------QESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEER 334 A+EA R+ +E+ Q E +L ++AL RLE Q+ L +E+ Sbjct: 757 EAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALEARLEEAQRGLARLGQEQ 816 Query: 335 DAARAGQLSEHRELETLR---AALEEERQTWAQQEHQLKEHYQALQEES-------QAQL 384 E ++ E LR A LEE+++ + +L + + + E+S QAQL Sbjct: 817 QTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELEKIGEDSKQALQQLQAQL 876 Query: 385 EREKEKSQRE-----------AQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEM 433 E KEK++RE A A +T L+ +Q E++RL L ++ ERD +L+ Sbjct: 877 EDYKEKARREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDK 936 Query: 434 SLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQ 493 L+ R Q ++ E+E + + +L +E R L E K +L Sbjct: 937 ELLAQRL--QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDE--EKNTVELLTDRV 992 Query: 494 QELASQLAQFKVE-MAEREERQ---------QQVAEDYELRLA------REQARVCELQS 537 Q+ Q + E M ER RQ ++ +D + RLA + A + +L+S Sbjct: 993 NRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLES 1052 Query: 538 GNQQLEEQRVELVERLQAMLQA 559 NQ L+E R++ ER + +LQ+ Sbjct: 1053 QNQLLQE-RLQAEEREKTVLQS 1073 Score = 73.6 bits (179), Expect = 8e-13 Identities = 112/430 (26%), Positives = 186/430 (43%), Gaps = 69/430 (16%) Query: 207 LQTRVLELQQQLAVAVAADRKKDTMIEQLDKT---LARVVEGWNR-------HEAERTEV 256 L+T+V+ELQ +L + K+ +++ L +T L V+EG R E E T + Sbjct: 441 LETQVMELQNKLKHVQGPEPAKEVLLKDLLETRELLEEVLEGKQRVEEQLRLRERELTAL 500 Query: 257 LRGLQEE----HQAAELTRSKQQETVTRLEQSLSEAME-----ALNREQESARLQ--QRE 305 L+EE Q E R + Q +L +S+ +A + R++ SA ++ QRE Sbjct: 501 KGALKEEVASRDQEVEHVRQQYQRDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRE 560 Query: 306 RETLEEER-------QALTLRLEAEQQRCCVLQEERDAARAGQLSE-----HRELETLRA 353 E EE Q L A +Q L+ E++ +L E RELE RA Sbjct: 561 LEETSEETGHWQSMFQKNKEDLRATKQELLQLRMEKEEMEE-ELGEKIEVLQRELEQARA 619 Query: 354 ALEEERQTWAQQEHQLK--EHYQALQEESQAQ------LEREKEKS----QREAQAAWET 401 + + RQ ++ L+ E + LQ E Q+Q +RE EK + EA E Sbjct: 620 SAGDTRQVEVLKKELLRTQEELKELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGREL 679 Query: 402 QHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLES---------ELA 452 + Q +Q +++L + + A + + + E +++ R + L Sbjct: 680 EEQNLQLQKTLQQLRQDCEEASKAKMVAEAEATVLGQRRAAVETTLRETQEENDEFRRRI 739 Query: 453 VQLEQRVTERL-----AQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507 + LEQ++ E +A E+ LR E ++QL++ Q+E S A + Sbjct: 740 LGLEQQLKETRGLVDGGEAVEARLRDKLQRLEAEKQQLEEALNASQEEEGSLAAAKRALE 799 Query: 508 AEREERQQQVA----EDYEL-RLAREQARVCE-LQSGNQQLEEQRVEL---VERLQAMLQ 558 A EE Q+ +A E L R E+ + E L+ G +LEEQ+ L V+RL L+ Sbjct: 800 ARLEEAQRGLARLGQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLNKELE 859 Query: 559 AHWDEANQLL 568 +++ Q L Sbjct: 860 KIGEDSKQAL 869 Score = 61.2 bits (147), Expect = 4e-09 Identities = 82/321 (25%), Positives = 149/321 (46%), Gaps = 47/321 (14%) Query: 105 QLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEE 164 QLQ L+ ++ A R+ A ++R+ +D + S++ T LQD QAL+ Sbjct: 871 QLQAQLEDYKEKARREV----ADAQRQAKD-WASEAEKTSGGLSRLQD-EIQRLRQALQA 924 Query: 165 LFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAA 224 + R L QGL +++ + R ++ L+ +V L+ +L Sbjct: 925 SQAERDTARLDKELLAQRLQGLEQEAENKKRSQDDRARQLKGLEEKVSRLETEL------ 978 Query: 225 DRKKDTMIEQLDKTLARVVEGWNRHEAERTEVL--RGLQEEHQAAELTRSKQQETV-TRL 281 D +K+T+ D RV G ++ + RTE++ R +++ + +++ +Q + + TRL Sbjct: 979 DEEKNTVELLTD----RVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRL 1034 Query: 282 EQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQ 341 S ++ SA L Q LE + Q L RL+AE++ VLQ Sbjct: 1035 ASSEGF-------QKPSASLSQ-----LESQNQLLQERLQAEEREKTVLQSTNRKLE--- 1079 Query: 342 LSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQ---EESQAQLER---EKEKSQREA 395 R+++ L +E+ERQ Q+ QL +AL+ +E++ ++ER ++K+QRE Sbjct: 1080 ----RKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEEIERLDGLRKKAQREV 1135 Query: 396 QAAWETQHQLALVQSEVRRLE 416 + E QL Q+ ++ LE Sbjct: 1136 EEQHEVNEQL---QARIKSLE 1153 Score = 54.7 bits (130), Expect = 4e-07 Identities = 90/452 (19%), Positives = 173/452 (38%), Gaps = 55/452 (12%) Query: 211 VLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELT 270 +L QQ+ A + D K T+ L EG + E + + E+ Q + Sbjct: 298 LLRDQQEAAPPGSVDHMKATIYGILR-------EGSSESETSVRRKVSLVLEKMQPLVMV 350 Query: 271 RSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVL 330 S + V + L+ +E L R+ + + ++R+ LE + L +LE + + C L Sbjct: 351 SSGSTKAVAG-QGELTRKVEELQRKLDE---EVKKRQKLEPSQVGLERQLEEKTEECSRL 406 Query: 331 QEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKE------HYQALQEESQAQL 384 QE + + ++EL+ ++ L++ E Q+ E H Q + + L Sbjct: 407 QELLERRKGEAQQSNKELQNMKRLLDQGEDLRHGLETQVMELQNKLKHVQGPEPAKEVLL 466 Query: 385 E---REKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE 441 + +E + + + QL L + E+ L+G L RD E+ V+ +Y+ Sbjct: 467 KDLLETRELLEEVLEGKQRVEEQLRLRERELTALKGALKEEVASRDQ---EVEHVRQQYQ 523 Query: 442 SQRIQL--------ESELAVQLEQRVTERLAQAQESSLRQAASLREH----HRKQLQDLS 489 QL + ++ E++ L + + L + + H +K +DL Sbjct: 524 RDTEQLRRSMQDATQDHAVLEAERQKMSALVRGLQRELEETSEETGHWQSMFQKNKEDLR 583 Query: 490 GQHQ---------QELASQLAQFKVEMAEREERQQQVA-------EDYELRLAREQARVC 533 Q +E+ +L + K+E+ +RE Q + + E + L R Q + Sbjct: 584 ATKQELLQLRMEKEEMEEELGE-KIEVLQRELEQARASAGDTRQVEVLKKELLRTQEELK 642 Query: 534 ELQSGNQQLE---EQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQ 590 ELQ+ Q E R +E+ A+L+ D +L L + Sbjct: 643 ELQAERQSQEVAGRHRDRELEKQLAVLRVEADRGRELEEQNLQLQKTLQQLRQDCEEASK 702 Query: 591 EPEKEERRVWTMPPMAVALKPVLQQSREARDE 622 E + A++ L++++E DE Sbjct: 703 AKMVAEAEATVLGQRRAAVETTLRETQEENDE 734 Score = 52.4 bits (124), Expect = 2e-06 Identities = 77/349 (22%), Positives = 146/349 (41%), Gaps = 20/349 (5%) Query: 104 GQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALE 163 GQ Q L + + + + G EE D T LN + L+ + S QAL+ Sbjct: 813 GQEQQTLNRALEEEGKQREVLRRGKAELEEQKRLLDRTVDRLN-KELEKIGEDSK-QALQ 870 Query: 164 ELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVA 223 +L + + D Q R A D K + LQ + L+Q L + A Sbjct: 871 QLQAQLEDYKEKARREVADAQ--RQAKDWASEAEK-TSGGLSRLQDEIQRLRQALQASQA 927 Query: 224 ----ADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVT 279 A K+ + ++L + L + E R + +R L+GL+E+ E +++ TV Sbjct: 928 ERDTARLDKELLAQRL-QGLEQEAENKKRSQDDRARQLKGLEEKVSRLETELDEEKNTVE 986 Query: 280 RLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE-ERDAAR 338 L ++ + +++ + ++ R+ LE ++ +L + + + R + ++ +A Sbjct: 987 LLTDRVNRGRDQVDQLRTELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSAS 1046 Query: 339 AGQLSEHRELETLRAALEEERQTWAQQ-----EHQLKEHYQALQEESQAQLEREKEKSQR 393 QL +L R EE +T Q E ++KE +++E Q +++ + S R Sbjct: 1047 LSQLESQNQLLQERLQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLR 1106 Query: 394 EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYES 442 + Q+ + E+ RL+G A+RE + +QAR +S Sbjct: 1107 VKAL----KRQVDEAEEEIERLDGLRKKAQREVEEQHEVNEQLQARIKS 1151 Score = 51.6 bits (122), Expect = 3e-06 Identities = 99/478 (20%), Positives = 188/478 (39%), Gaps = 75/478 (15%) Query: 81 VGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDS 140 +GLE+ LK+ G + E+V +L+ LQ R A + L + + EE S Sbjct: 740 LGLEQQLKETRGL--VDGGEAVEARLRDKLQ--RLEAEKQQLEEALNASQEEEGSL---- 791 Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200 A A L R + G + Q L AL+ E +R Sbjct: 792 ------------------AAAKRALEARLEEAQRGLARLGQEQQTLNRALEEEGKQR--- 830 Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260 + L+ EL++Q + DR D + ++L+K + + +A+ + Sbjct: 831 ----EVLRRGKAELEEQKRLL---DRTVDRLNKELEKIGEDSKQALQQLQAQLEDYKEKA 883 Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320 + E A+ + LS + + R +++ + Q ER+T +++ L RL Sbjct: 884 RREVADAQRQAKDWASEAEKTSGGLSRLQDEIQRLRQALQASQAERDTARLDKELLAQRL 943 Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALEEERQT----------WAQQEHQL 369 + +Q + +D RA QL E + L L+EE+ T Q QL Sbjct: 944 QGLEQEAENKKRSQDD-RARQLKGLEEKVSRLETELDEEKNTVELLTDRVNRGRDQVDQL 1002 Query: 370 KEHYQALQEESQAQ-LEREKEKSQRE----------AQAAWETQHQLALVQSEVRRLEGE 418 + + +QE S Q LE +K +R+ ++ + L+ ++S+ + L+ Sbjct: 1003 RT--ELMQERSARQDLECDKISLERQNKDLKTRLASSEGFQKPSASLSQLESQNQLLQER 1060 Query: 419 LDTARRERDALQLEMSLVQARYESQRIQLESEL--------AVQLEQRVTERLAQAQESS 470 L RE+ LQ ++ + + IQ+E E + L + +R E Sbjct: 1061 LQAEEREKTVLQSTNRKLERKVKELSIQIEDERQHVNDQKDQLSLRVKALKRQVDEAEEE 1120 Query: 471 LRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528 + + LR+ ++++++ Q E+ QL Q +++ E++ ++ E L E Sbjct: 1121 IERLDGLRKKAQREVEE-----QHEVNEQL-QARIKSLEKDSWRKASRSAAESALKNE 1172 >gi|239745127 PREDICTED: similar to Putative golgin subfamily A member 6-like protein 6 [Homo sapiens] Length = 655 Score = 87.0 bits (214), Expect = 7e-17 Identities = 92/407 (22%), Positives = 185/407 (45%), Gaps = 37/407 (9%) Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246 RDAL E R + + L+ + ELQ++L + + + ++ L + L Sbjct: 199 RDALSLELYRNTITD---EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL------- 248 Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSL--SEAMEALNREQESARLQQR 304 ER ++L Q+ A+ + Q +L+ + +E LN++QE +Q Sbjct: 249 -----ERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQE 303 Query: 305 ERETLEEER---QALTLRLEAE----QQRCCVLQEERDAARAGQL--SEHRELETLRAAL 355 E+ +EE+ Q L +R + E Q+ QEE+ + ++ E + E Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363 Query: 356 EEERQTWAQQE--HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVR 413 E+E + W Q+E + E Q +EE Q E+ +E+ ++ + W + ++ ++R Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIR 423 Query: 414 RLEGELDTARRERDALQLEMSL----VQARYESQRIQLESELAVQLE---QRVTERLAQA 466 E E+ R+E +LE + + R +++Q E E + E QR E++ + Sbjct: 424 EQEEEM--WRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQ 481 Query: 467 QESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLA 526 +E + RQ L++ + Q+ Q+E + + E E+ +RQ++ + E+RL Sbjct: 482 EEKTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLW 541 Query: 527 REQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLP 573 +++ ++ E + Q+LEE+ +L ++ + + A + +Q L T P Sbjct: 542 QQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP 588 Score = 54.7 bits (130), Expect = 4e-07 Identities = 56/267 (20%), Positives = 123/267 (46%), Gaps = 21/267 (7%) Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 +ER+ L E T+ E +++ LQE+ + + ++ L+ LE + Sbjct: 197 KERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLP 256 Query: 364 QQEHQ-----LKEHYQALQEESQAQLEREK---EKSQREAQAAWETQHQLALVQSEVRRL 415 QQ+ Q L + Q++ + QAQ+E + +Q++ + W + ++ + E + Sbjct: 257 QQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ--EQEEKMC 314 Query: 416 EGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRV---TERLAQAQESSLR 472 E EL +E + E + + + ++I+ + + + E+++ E++ + +E R Sbjct: 315 EQELKIREQEEKMWRQEEKMHE---QEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWR 371 Query: 473 QAASLREHHRK-QLQDLSGQHQQELASQLAQFKVEMAEREER----QQQVAEDYELRLAR 527 Q +RE K Q Q+ Q+E + + + E R+E+ Q + + E + R Sbjct: 372 QEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR 431 Query: 528 EQARVCELQSGNQQLEEQRVELVERLQ 554 ++ ++ EL+ Q EE+ E+ E++Q Sbjct: 432 QEEKIRELEEMMQDQEEKLREVEEKMQ 458 >gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] Length = 2017 Score = 87.0 bits (214), Expect = 7e-17 Identities = 107/398 (26%), Positives = 182/398 (45%), Gaps = 50/398 (12%) Query: 184 QGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV 243 QGL +L ++ E+ + +L+ +LQ+QLA ++ +EQ + R V Sbjct: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGREQELEQARREAQRQV 861 Query: 244 EGWNRHEAERTEVLR---GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEA--LNREQES 298 E R E+ + + GL + AAE E TRL EA+E +++ Sbjct: 862 EALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLE-KEALEGSLFEVQRQL 920 Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358 A+L+ R RE LE E QAL L E L+++ A + +A+L++E Sbjct: 921 AQLEAR-REQLEAEGQALLLAKETLTGELAGLRQQIIATQE------------KASLDKE 967 Query: 359 RQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAW-ETQHQLALVQSEVRRLEG 417 AQ+ Q + QA E +A E + ++ QRE +AAW E + + A +QS+++R + Sbjct: 968 --LMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEAAWRELEAERAQLQSQLQREQE 1025 Query: 418 ELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 EL AR E+++ +L E+A L+Q E L A ES +QA SL Sbjct: 1026 EL-----------------LARLEAEKEELSEEIAA-LQQERDEGLLLA-ESEKQQALSL 1066 Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQ--------VAEDYELRLAREQ 529 +E + L + + LA+ + + + + + RQ+Q +E +LR RE+ Sbjct: 1067 KESEKTALSEKLMGTRHSLATISLEMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREE 1126 Query: 530 ARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567 A Q ++L+EQ +L ++ + L+ + QL Sbjct: 1127 AAAAHAQE-VRRLQEQARDLGKQRDSCLREAEELRTQL 1163 Score = 78.2 bits (191), Expect = 3e-14 Identities = 105/342 (30%), Positives = 153/342 (44%), Gaps = 48/342 (14%) Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260 E Q+LQ RV LQ+Q+A + +E+L+ LA+V E E + +RGL Sbjct: 1676 EAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEES----EGALRDKVRGL 1731 Query: 261 QEE--HQAAEL--TRSKQ---QETVTRLE---QSLSEAMEALNREQESARLQQ----RER 306 E +A L TR K Q+ +T E Q L E ++A + AR Q + Sbjct: 1732 TEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEARKQSSSLGEQV 1791 Query: 307 ETLEEERQALTL-RLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER------ 359 +TL E L L R+EAE Q LQ+ R+ R Q E L T++ +E R Sbjct: 1792 QTLRGEVADLELQRVEAEGQ----LQQLREVLRQRQEGEAAALNTVQKLQDERRLLQERL 1847 Query: 360 ----QTWAQQEHQLKE-HYQALQ-EESQAQLEREKEKSQREAQAAWETQHQLALVQSEV- 412 + AQ E + +E AL+ E+ + L R +K +RE + E +L+ + + Sbjct: 1848 GSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRLSAEKGRLD 1907 Query: 413 RRLEG-ELDTARRERDALQLEMSLVQARYESQRIQLE---SELAVQLEQRVTERLAQAQE 468 R L G EL+ A +R QLE +V QLE + ++L+Q V ERL AQ Sbjct: 1908 RTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLELQQEV-ERLRSAQA 1966 Query: 469 SSLRQAASLREHHR-------KQLQDLSGQHQQELASQLAQF 503 + R + HR +Q+ L GQ QQEL A F Sbjct: 1967 QTERTLEARERAHRQRVRGLEEQVSTLKGQLQQELRRSSAPF 2008 Score = 77.4 bits (189), Expect = 6e-14 Identities = 133/548 (24%), Positives = 228/548 (41%), Gaps = 92/548 (16%) Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDS----FDS 138 LEK+ KD ++ + +ES+R Q Q L+T + L A + + +S S Sbjct: 414 LEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRDLAQAVLSDSESGVQLSGS 473 Query: 139 DSTATLLNTRPLQDLSPSSSAQALEELFP-RYTSLRPGP--------------------P 177 + TA N L+ LS + P R S R GP Sbjct: 474 ERTADASN-GSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKRQ 532 Query: 178 LNPPDFQG-----------LRDALDSEHTRRKHCERHIQSLQTR---VLELQQQLAVAVA 223 L D +G LR L + R+ E +Q L+ + ++ + V Sbjct: 533 LQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREVQ 592 Query: 224 ADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQ 283 R + ++ + LA ++ ++ E LR +E+ QAA+ +Q++ RLE+ Sbjct: 593 RLRSANELLSREKSNLAHSLQ----VAQQQAEELRQEREKLQAAQEELRRQRD---RLEE 645 Query: 284 SLSEAMEALNREQESARLQQRERETLEEERQAL--------------TLRLEAEQQRCCV 329 +A++ R + R+ E LE +R L TL+ + Q Sbjct: 646 EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQRDMLQAEKAE 705 Query: 330 LQEERDAARAGQLSEHRELETLRA----------ALEEERQTWAQQEHQLKEHYQALQEE 379 + E A AG++ + LRA L ++ AQ + L L+EE Sbjct: 706 VAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQDKLDLNRLVAQLEEE 765 Query: 380 SQAQLEREKEKSQREAQAAWETQHQL--ALVQSEVRR--LEGELDTARRERDALQLEMSL 435 A L+ + ++++EA A E Q +L ++ EV R LEG L A + ++A LE L Sbjct: 766 KSA-LQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQEA--LEQQL 822 Query: 436 VQARYESQRIQLE-SELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQ 494 R+E ++Q + ++L+ QL R E L QA+ + RQ +L + + + ++ Sbjct: 823 PTLRHERSQLQEQLAQLSRQLSGREQE-LEQARREAQRQVEAL---------ERAAREKE 872 Query: 495 ELASQLAQFKVEMAEREERQQQVAED-YELRLARE--QARVCELQSGNQQLEEQRVELVE 551 LA + A V++ E + ++E+ LRL +E + + E+Q QLE +R +L Sbjct: 873 ALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEALEGSLFEVQRQLAQLEARREQLEA 932 Query: 552 RLQAMLQA 559 QA+L A Sbjct: 933 EGQALLLA 940 Score = 75.1 bits (183), Expect = 3e-13 Identities = 113/396 (28%), Positives = 170/396 (42%), Gaps = 80/396 (20%) Query: 188 DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247 +AL R E + L+ LQ L+ + L+++LA+ N Sbjct: 708 EALTKAEAGRVELELSMTKLRAEEASLQDSLS-----------KLSALNESLAQDKLDLN 756 Query: 248 RHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQE--------SA 299 R A+ E LQ + AE Q+ TV R EQ E +E L EQE S Sbjct: 757 RLVAQLEEEKSALQGRQRQAE-----QEATVAREEQ---ERLEELRLEQEVARQGLEGSL 808 Query: 300 RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEER 359 R+ ++ +E LE+ Q TLR E Q LQE+ A+ + RE E +A E +R Sbjct: 809 RVAEQAQEALEQ--QLPTLRHERSQ-----LQEQ--LAQLSRQLSGREQELEQARREAQR 859 Query: 360 QTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGEL 419 Q E+ + REKE +E QL + E R L E Sbjct: 860 QV-----------------EALERAAREKEALAKEHAG---LAVQLVAAEREGRTLSEEA 899 Query: 420 DTARRERDALQLEMSLVQ---ARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAAS 476 R E++AL+ + VQ A+ E++R QLE+E + L A+E+ + A Sbjct: 900 TRLRLEKEALEGSLFEVQRQLAQLEARREQLEAE---------GQALLLAKETLTGELAG 950 Query: 477 LREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREE----RQQQVAEDYEL-RLARE-QA 530 LR+ Q ++ Q + L +L K+ AERE R+Q+ A + +L RL RE +A Sbjct: 951 LRQ------QIIATQEKASLDKELMAQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA 1004 Query: 531 RVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566 EL++ QL+ Q E L A L+A +E ++ Sbjct: 1005 AWRELEAERAQLQSQLQREQEELLARLEAEKEELSE 1040 Score = 68.6 bits (166), Expect = 3e-11 Identities = 130/514 (25%), Positives = 198/514 (38%), Gaps = 80/514 (15%) Query: 74 ELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREE 133 E +R+ + L L +G E E R ++Q ++ R L G G R Sbjct: 1392 EAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPS 1451 Query: 134 DSFDSDSTATLLNTRPLQDLSPSSSAQALE-----ELFPRYTSLRPGPPLNP--PDF--Q 184 + + P +D S + L E P PGP +P PD + Sbjct: 1452 PA------PRPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPE 1505 Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE 244 +R AL + +R L+T+ L +QLA A + QL K +A Sbjct: 1506 AVRGALREFLQELRSAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAE--- 1562 Query: 245 GWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR 304 EA R+ ++ LS L ++ES R +R Sbjct: 1563 ---SEEARRS--------------------------VDGRLSGVQAELALQEESVRRSER 1593 Query: 305 ERE-------TLEEERQALTLRLEAEQQRCCVLQE-----ERDAARAGQL---SEHR--E 347 ER TLE QA L A Q++ ++ E D R ++ SE R + Sbjct: 1594 ERRATLDQVATLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVK 1653 Query: 348 LETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLAL 407 LE R +LE E Q + QALQ+ + L+R+ S+ +A T +L Sbjct: 1654 LELQRRSLEGELQRSRLGLSDREAQAQALQDRVDS-LQRQVADSEVKAGTLQLTVERLNG 1712 Query: 408 VQSEVRRLEGEL-DTARRERDAL-QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ 465 ++V EG L D R +AL Q SL R ++ +Q Q + ERL Sbjct: 1713 ALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDA 1772 Query: 466 AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 A RQA S RKQ L G+ Q L ++A +++ E E + QQ+ E R Sbjct: 1773 A-----RQALS---EARKQSSSL-GEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQ 1823 Query: 526 AREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559 E A + + Q+L+++R L ERL ++ +A Sbjct: 1824 EGEAAALNTV----QKLQDERRLLQERLGSLQRA 1853 Score = 62.0 bits (149), Expect = 2e-09 Identities = 135/643 (20%), Positives = 242/643 (37%), Gaps = 94/643 (14%) Query: 27 LNQVSSEVTSQLYASLRLSRQAEATAR--AQLYLPSTSPPHEG----------------L 68 L Q E Q+ A R +R+ EA A+ A L + + EG L Sbjct: 850 LEQARREAQRQVEALERAAREKEALAKEHAGLAVQLVAAEREGRTLSEEATRLRLEKEAL 909 Query: 69 DGFAQELSRSLS-VGLEKNLKKKDGSKHIFEMESVRGQLQTMLQ---TSRDTAYRDPLIP 124 +G E+ R L+ + + + +G + E++ G+L + Q +++ A D + Sbjct: 910 EGSLFEVQRQLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELM 969 Query: 125 GAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQ 184 + E ++ S + LQ L A A EL L Q Sbjct: 970 AQKLVQAEREAQASLREQRAAHEEDLQRLQREKEA-AWRELEAERAQL-----------Q 1017 Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTM-IEQLDKTLARVV 243 E R E+ S + L+ ++ + +A K+ + +++ +KT Sbjct: 1018 SQLQREQEELLARLEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTALSEK 1077 Query: 244 EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAME-----ALNREQES 298 RH + ++ + + A+ + + + TV L L + A QE Sbjct: 1078 LMGTRHSLATISL--EMERQKRDAQSRQEQDRSTVNALTSELRDLRAQREEAAAAHAQEV 1135 Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358 RLQ++ R+ L ++R + E + + +L++ RD R L R+L + E + Sbjct: 1136 RRLQEQARD-LGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQEGREVQ 1194 Query: 359 RQTWAQQEHQL------KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQ--- 409 RQ + L +E + EE ++ +++ + + A + + +LAL++ Sbjct: 1195 RQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEAR 1254 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQ---- 465 + V + GEL T +E +E S ++AR E Q ++ + ++ R+ LA+ Sbjct: 1255 TAVGKEAGELRTGLQE-----VERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGR 1309 Query: 466 ------AQESSLRQAASLREHHRKQLQDLSGQHQQ------ELASQLAQFK--------- 504 A++ S R+ LR+ K L Q+ +L Q +F+ Sbjct: 1310 LALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGS 1369 Query: 505 VEMAEREERQQ-QVAEDYELRLAREQARVCEL------QSGNQQLEEQRVELVERLQAML 557 +E A E+QQ A EL+L +A EL G Q E + VE + Sbjct: 1370 LEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAA 1429 Query: 558 QAHWDEANQLLSTTL-----PPPNPPAPPAGPSSPGPQEPEKE 595 +A L L P P P P P+ P E E Sbjct: 1430 EAQLGGLRSALRRGLGLGRAPSPAPRPVPGSPARDAPAEGSGE 1472 Score = 54.7 bits (130), Expect = 4e-07 Identities = 50/176 (28%), Positives = 88/176 (50%), Gaps = 9/176 (5%) Query: 402 QHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE-SELAVQLEQRVT 460 Q + L+Q E+ R+E L +R ERD L ++ + V R E Q ++LE EL Q + + Sbjct: 80 QEENQLLQQELSRVEDLLAQSRAERDELAIKYNAVSERLE-QALRLEPGELETQEPRGLV 138 Query: 461 ERLAQAQESSLRQAASLREHHR--KQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVA 518 + + + + AS R + ++ Q Q Q L ++ Q+K +E E++ + + Sbjct: 139 RQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERS 198 Query: 519 EDYELRLAREQARVCELQSGNQQLEE--QRVELVERLQAMLQAHWDE---ANQLLS 569 + E + R+ +L+S +LEE QR + ++ AML+ D+ ANQ LS Sbjct: 199 GELEQQRLRDTEHSQDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALS 254 Score = 53.9 bits (128), Expect = 7e-07 Identities = 108/437 (24%), Positives = 179/437 (40%), Gaps = 77/437 (17%) Query: 151 QDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTR 210 QD +S + E+ R S P L P +L E+ + ++ L + Sbjct: 40 QDAQITSLPALIREIVTRNLSQPESPVLLPATEMASLLSLQEENQLLQQELSRVEDLLAQ 99 Query: 211 VLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER------TEVLRGLQEEH 264 + +LA+ K + + E+L++ L R+ G + R E+ R LQEE Sbjct: 100 SRAERDELAI------KYNAVSERLEQAL-RLEPGELETQEPRGLVRQSVELRRQLQEEQ 152 Query: 265 -------QAAELTRSKQQETVTRLEQSLSE------AMEALNREQESARLQQRERETLE- 310 QA + + +Q + V RL+ + + +E E+ QQR R+T Sbjct: 153 ASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKRCSELEQQLLERSGELEQQRLRDTEHS 212 Query: 311 EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLK 370 ++ ++ +RLE EQQR L + R + L + + W + +L Sbjct: 213 QDLESALIRLEEEQQRSASLAQVNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKEL- 271 Query: 371 EHYQALQEESQAQLEREKEKSQREAQAAWETQH-QLALVQSEV---RRLEGELDTARRER 426 E +A RE+E A + +H +L L+ +V RRL E+ ER Sbjct: 272 -------EHREAAWRREEE----SFNAYFSNEHSRLLLLWRQVVGFRRLVSEVKMF-TER 319 Query: 427 DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQ 486 D LQL L + + R E+ L + R+ E A E++L + A L+ +QL+ Sbjct: 320 DLLQLGGELAR----TSRAVQEAGLGLSTGLRLAESRA---EAALEKQALLQAQLEEQLR 372 Query: 487 DLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQR 546 D KV + E++ QQQ+ D L A ARV EL ++LE+Q Sbjct: 373 D----------------KV-LREKDLAQQQMQSD--LDKADLSARVTELGLAVKRLEKQN 413 Query: 547 VE-------LVERLQAM 556 +E L E+L+A+ Sbjct: 414 LEKDQVNKDLTEKLEAL 430 Score = 52.8 bits (125), Expect = 1e-06 Identities = 112/441 (25%), Positives = 179/441 (40%), Gaps = 90/441 (20%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ-LDKTLARVVEGWNRHEAERTE 255 +K C Q L R EL+QQ R +DT Q L+ L R+ E R A + Sbjct: 184 KKRCSELEQQLLERSGELEQQ--------RLRDTEHSQDLESALIRLEEEQQR-SASLAQ 234 Query: 256 VLRGLQEEHQAAELTRSKQQETV-------TRLEQSLSEAMEALNREQES---------A 299 V L+E+ A E + TR + L A RE+ES + Sbjct: 235 VNAMLREQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHS 294 Query: 300 RLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQ-----LSEHRELETLRA- 353 RL R+ + R +++ E+ + E +RA Q LS L RA Sbjct: 295 RLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTGLRLAESRAE 354 Query: 354 -ALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEV 412 ALE++ AQ E QL++ ++ +Q Q++ + +K+ A+ T+ LA V Sbjct: 355 AALEKQALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARV---TELGLA-----V 406 Query: 413 RRLEGELDTARRERDALQLEMSLVQARYESQRIQ----LESELAVQLEQRVTERLAQA-- 466 +RLE + E+D + +++ ES R+Q LE+E L+Q + + LAQA Sbjct: 407 KRLEKQ----NLEKDQVNKDLTEKLEALESLRLQEQAALETEDGEGLQQTLRD-LAQAVL 461 Query: 467 --QESSLRQAASLR--EHHRKQLQDLSGQHQQEL----------------------ASQL 500 ES ++ + S R + L+ LSGQ +S L Sbjct: 462 SDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTL 521 Query: 501 AQFKVEMAEREERQQQVAEDYELR---LAREQARVCELQSGNQQLEEQRVELVERLQAML 557 A + +R+ + Q + YE L + ++ + +S + LEEQ L ++ + Sbjct: 522 ALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 581 Query: 558 QAHWD---------EANQLLS 569 QAH D AN+LLS Sbjct: 582 QAHEDAQREVQRLRSANELLS 602 >gi|122937382 Fas (TNFRSF6) binding factor 1 [Homo sapiens] Length = 1133 Score = 85.9 bits (211), Expect = 2e-16 Identities = 111/440 (25%), Positives = 187/440 (42%), Gaps = 72/440 (16%) Query: 203 HIQSLQTRVLELQQQLAVAVAAD---RKKDTMIEQLDKTLARVVEGWNRHEA-------- 251 H + LQ L +++ A +A R +++I Q++K + + E +R EA Sbjct: 708 HEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELSSRVEASHLTTSQE 767 Query: 252 ------ERTEVLRGLQE----EHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301 +R E LR LQE + + E RS+QQE + ++E L+E L +E+ Sbjct: 768 RELGIRQRDEQLRALQERLGQQQRDMEEERSRQQEVIGKMEARLNEQSRLLEQERWRVTA 827 Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361 +Q + E+++ L+E+R E ELE ++AL EE+++ Sbjct: 828 EQSKAESMQR-----------------ALEEQRKVTAQQMAMERAELERAKSALLEEQKS 870 Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421 + + + A E AQ + KE+++REA+ A + Q EG L + Sbjct: 871 VMLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQ----------REGTLIS 920 Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 +E+ L++ S ++A + QL +E A ++R RL E A +LR Sbjct: 921 LAKEQAELKIRASELRA----EEKQLAAERAALEQERQELRL----EKERINATALRVKL 972 Query: 482 RKQLQDLSGQHQQELASQLAQFKVEMAEREERQ-QQVAEDYELRLAREQARVCELQSGNQ 540 R + + E S++A K E ER R+ QQV + + RL Q + L+ Q Sbjct: 973 RAE--------EVESMSKVASEKYEEGERALREAQQVQAEQQARLQAVQQQQERLRKQEQ 1024 Query: 541 QLEEQRVELV-ERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERRV 599 + ++ + L +RLQ D A Q L ++L P A SS P R Sbjct: 1025 HMHQEHLSLAQQRLQL------DRARQDLPSSLVGLFPRAQGPAASSQSALMPPAPTTRW 1078 Query: 600 WTMPPMAVALKPVLQQSREA 619 + PP + P+ +R A Sbjct: 1079 CSQPPTGLDPSPLHLHARLA 1098 Score = 64.3 bits (155), Expect = 5e-10 Identities = 109/445 (24%), Positives = 176/445 (39%), Gaps = 91/445 (20%) Query: 174 PGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIE 233 P PL P R L S +++ +Q LQ ELQ +L + A + + + Sbjct: 541 PVQPLLPESLA--RSLLPSTEYQKQLLAAQVQ-LQCSPAELQAELLHSQARLAELEAQVR 597 Query: 234 QLDKTLARVVEGWNRHEAERTEVLRGLQEEHQA-AELTRSKQQETVTRLEQSLSEAMEAL 292 +L+ A+ HE +L LQ++HQA EL S + + LE S + E L Sbjct: 598 KLELERAQ-------HEL----LLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERL 646 Query: 293 NREQESARLQQRERETLEEERQALTLRLEAEQQR-----------CCVLQEE-------R 334 RE E E + L+ EAEQ R + QE+ R Sbjct: 647 RRENE------------ELSARYLSQCQEAEQARAELTAQHQRRLAAIAQEKDQEMERLR 694 Query: 335 DAARAGQLSEHR--ELETLRAALEEERQTWAQQE------------HQLKEHYQALQEES 380 + RA L R E + R L ++R+ A HQ+++ +L E S Sbjct: 695 ELQRASILDMRRDHEEQLQRLKLLKDREVDAATSATSHTRSLNSIIHQMEKFSSSLHELS 754 Query: 381 QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY 440 SQ + QL +Q + + + +++ ER Q + ++AR Sbjct: 755 SRVEASHLTTSQERELGIRQRDEQLRALQERLGQQQRDME---EERSRQQEVIGKMEARL 811 Query: 441 ESQRIQLESE---------------LAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL 485 Q LE E A++ +++VT + + + L +A S +K + Sbjct: 812 NEQSRLLEQERWRVTAEQSKAESMQRALEEQRKVTAQQMAMERAELERAKSALLEEQKSV 871 Query: 486 QDLSGQHQQELASQLAQFKV------EMAERE-ERQQQVAEDYE---LRLAREQA----R 531 G+ ++ LA++ A+F E AERE ER QV E + LA+EQA R Sbjct: 872 MLKCGEERRRLAAEWAEFSAQQKLSKERAEREAERALQVDTQREGTLISLAKEQAELKIR 931 Query: 532 VCELQSGNQQLEEQRVELVERLQAM 556 EL++ +QL +R L + Q + Sbjct: 932 ASELRAEEKQLAAERAALEQERQEL 956 Score = 32.7 bits (73), Expect = 1.6 Identities = 24/76 (31%), Positives = 38/76 (50%), Gaps = 4/76 (5%) Query: 495 ELASQLAQFKVEMAERE----ERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELV 550 EL +Q+ + ++E A+ E QQQ D EL + ++R+ L++ QQ EE+ Sbjct: 591 ELEAQVRKLELERAQHELLLGSLQQQHQADLELIESAHRSRIKVLETSYQQREERLRREN 650 Query: 551 ERLQAMLQAHWDEANQ 566 E L A + EA Q Sbjct: 651 EELSARYLSQCQEAEQ 666 >gi|21735548 centrosomal protein 2 [Homo sapiens] Length = 2442 Score = 85.5 bits (210), Expect = 2e-16 Identities = 121/474 (25%), Positives = 212/474 (44%), Gaps = 68/474 (14%) Query: 125 GAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQ 184 G+ E R E S DS ++ P Q+ + S LF R GP L + Sbjct: 1194 GSVCESRPELSGGGDSAPSVWGLEPDQNGARS--------LFKR------GPLLTALSAE 1239 Query: 185 GLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE 244 + AL H ++ L+ +V +L+++L A + T ++ L + L++ E Sbjct: 1240 AVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE 1299 Query: 245 GWNRHEAERT----------EVLRGLQEEHQAAELTRSKQQ---ETVTRLEQSLSEAMEA 291 ++ E ++ E + LQ + AEL R + Q E + +++L+ +E Sbjct: 1300 EKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEH 1359 Query: 292 LNREQESARLQQRERETLEEE----RQALTLR---LEAEQQRCCVLQEERD--AARAGQL 342 L AR Q LEE+ R AL L+ +E+E++R LQE+ + A+ L Sbjct: 1360 LQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKAL 1419 Query: 343 SEH------------RELETLRAALEE-ERQTWAQQEH------QLKEHYQA--LQEESQ 381 E+ E+ETLR ++E E+Q Q+ LK+ Q LQ+E Sbjct: 1420 QENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQI 1479 Query: 382 AQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYE 441 +LE+ + + A E + +L + + ++R LE + +T R + LE+ E Sbjct: 1480 QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539 Query: 442 SQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLA 501 SQR Q++ +L QL E LA E + + E +K +++L GQ + + + L Sbjct: 1540 SQRGQVQ-DLKKQLV--TLECLALELEENHHK----MECQQKLIKELEGQRETQRVA-LT 1591 Query: 502 QFKVEMAER-EERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554 +++ ER +E Q Q ++ ++L + ELQ +Q+++ QR E +E LQ Sbjct: 1592 HLTLDLEERSQELQAQSSQIHDLE-SHSTVLARELQERDQEVKSQR-EQIEELQ 1643 Score = 85.1 bits (209), Expect = 3e-16 Identities = 122/456 (26%), Positives = 200/456 (43%), Gaps = 87/456 (19%) Query: 182 DFQGLRDALDSE----HTRRKHCERHIQSLQTRVLELQQQLAVA-VAADRKKDTMIEQLD 236 + Q L+D L+ + H + + + ++ LQQQL A + K+ ++ QLD Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806 Query: 237 KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQ 296 + R A+R + L LQ+E Q A+ + +E L+ +L +A L Sbjct: 1807 EA--------QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERH 1858 Query: 297 ESARLQQRERETLEEER-------QAL-----TLRLEAEQQRCCVLQEERDAARAGQLSE 344 + + + LEEE QAL LR E+ +Q +L ++ A Q E Sbjct: 1859 GELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAE--QAQE 1916 Query: 345 HRELETLRAALEEERQTWAQQEHQLKEHYQ---ALQEESQAQLEREKEKSQR-------- 393 H E+ET AL++ +W Q + LKE Q AL+ ESQ+ +E+ R Sbjct: 1917 H-EVET--RALQD---SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEAL 1970 Query: 394 -EAQAAWETQHQLALVQSEV-RRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451 +A AA + + Q L Q+E+ R LE T + DA Q ++ E+ RIQ E E+ Sbjct: 1971 GKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLE---EALRIQ-EGEI 2026 Query: 452 AVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMA-ER 510 Q + R E + Q Q++ ++ LR H +++ Q L Q + + Q K + ER Sbjct: 2027 QDQ-DLRYQEDVQQLQQALAQRDEELR-HQQEREQLLEKSLAQRVQENMIQEKQNLGQER 2084 Query: 511 EERQ----QQVAEDYELRLAREQARVCELQSGNQQ--------------LEEQRVEL--- 549 EE + Q + +L LA+++ + EL+ Q+ +EEQ ++L Sbjct: 2085 EEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL 2144 Query: 550 -------VERLQAML------QAHWDEANQLLSTTL 572 +ERLQA L + W E Q L+ +L Sbjct: 2145 EPRLQRELERLQAALRQTEAREIEWREKAQDLALSL 2180 Score = 84.0 bits (206), Expect = 6e-16 Identities = 115/482 (23%), Positives = 214/482 (44%), Gaps = 66/482 (13%) Query: 147 TRPLQDLSPSSSAQA--LEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHI 204 T L++ S AQ+ + +L T L + + R+ ++ +++H + + Sbjct: 1594 TLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDL 1653 Query: 205 QSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEH 264 + + + L LQ++ + R + T I L++ L ++ E T + +QE Sbjct: 1654 ER-RDQELMLQKERIQVLEDQRTRQTKI--LEEDLEQIKLSLRERGRELTTQRQLMQERA 1710 Query: 265 QAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQAL-------T 317 + + Q+ ++ ++ L + + + +QE Q ++ LE++ Q L + Sbjct: 1711 EEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770 Query: 318 LRLEAEQQRCCVLQEE-RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQAL 376 L L +Q VLQ++ ++A G+L E ++L++ L+E ++ AQ++ +L E Q Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKE----QSLQSQLDEAQRALAQRDQEL-EALQQE 1825 Query: 377 QEESQAQLEREKEKSQREAQAAWETQH--------QLALVQSEVRRLEGELDTARRERDA 428 Q+++Q Q ER KEK+ Q A E H +L + + RRLE EL R A Sbjct: 1826 QQQAQGQEERVKEKAD-ALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQA 1884 Query: 429 LQLEMSLVQARYESQR---IQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK-- 483 L+ + ++A Q + L+ + A Q ++ E A Q+S L+ A L+E ++ Sbjct: 1885 LEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRA-LQDSWLQAQAVLKERDQELE 1943 Query: 484 --QLQDLSGQHQQELASQLAQFKVEM-----AEREERQQQVAEDYELRLARE------QA 530 + + S +HQ+E A A+ E A + ++Q + E EL + E QA Sbjct: 1944 ALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQA 2003 Query: 531 RVCELQSGNQQLEE-----------QRVELVERLQAMLQA---------HWDEANQLLST 570 + Q+ ++QLEE Q + E +Q + QA H E QLL Sbjct: 2004 SLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEK 2063 Query: 571 TL 572 +L Sbjct: 2064 SL 2065 Score = 83.2 bits (204), Expect = 1e-15 Identities = 96/400 (24%), Positives = 185/400 (46%), Gaps = 38/400 (9%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQ---LDKTLARVVEGW 246 L E + C R + Q R LQ LA A+++++ + E+ L+ L + E Sbjct: 620 LQLEEENQSVCSRMEAAEQARNA-LQVDLA---EAEKRREALWEKNTHLEAQLQKAEEAG 675 Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306 +A+ ++ +E + +R +Q+ T+LEQ EA R++E +E+ Sbjct: 676 AELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEA----KRQEEVLARAVQEK 731 Query: 307 ETLEEERQALTLRLEA-EQQRCCVLQEERDAARAGQLSE---------HRELETLRAALE 356 E L E+ AL +RL+A E+ R + ++ + + A +L E + +E + LE Sbjct: 732 EALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLE 791 Query: 357 EERQTWAQQEHQLKEHYQALQ-----EESQAQLERE---KEKSQREAQAAWETQHQLALV 408 + QT Q + ++ + L+ E SQA+ ER+ ++ +Q E + + Q A Sbjct: 792 VQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAH 851 Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE 468 + EV +L + + +ER Q E++ E ++++LE L EQ+ QAQ Sbjct: 852 EKEVNQLREKWE---KERSWHQQELAKALESLEREKMELEMRLK---EQQTEMEAIQAQR 905 Query: 469 SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528 R A E Q+Q + + + L L Q + E+A+ ++ +++ +D +++ +E Sbjct: 906 EEERTQA---ESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKE 962 Query: 529 QARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLL 568 Q LQ+ Q+ + + E + + L A +E++ LL Sbjct: 963 QETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLL 1002 Score = 80.9 bits (198), Expect = 5e-15 Identities = 112/474 (23%), Positives = 201/474 (42%), Gaps = 52/474 (10%) Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEG---WNRHEAERTEVL 257 E+ ++ Q + ELQ+ KD + +QL +V E ++ E E + Sbjct: 1735 EKEVECQQEHIHELQEL----------KDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQ 1784 Query: 258 RGLQEEHQAAELTRSKQQETVTRLEQSLSEA---MEALNREQESARLQQRERETLEEERQ 314 + LQE + EL Q + +++L++ +EAL +EQ+ A Q + E ++E+ Sbjct: 1785 QQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQA---QGQEERVKEKAD 1841 Query: 315 ALTLRLEAE----QQRCCVLQEERDAARAGQLSEHRELETLRA-ALEEERQTWAQQEHQL 369 AL LE ++R LQ+ ++ AR +L E +E R ALEE + + Sbjct: 1842 ALQGALEQAHMTLKERHGELQDHKEQAR--RLEEELAVEGRRVQALEEVLGDLRAESREQ 1899 Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAW-ETQHQLALVQSEVRRLEGELDTARRERDA 428 ++ ALQ++ A+ +E E R Q +W + Q L E+ L E ++R + +A Sbjct: 1900 EKALLALQQQC-AEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEA 1958 Query: 429 LQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQL--- 485 + +Q L+ + LEQ R +A ++L+ + + H +QL Sbjct: 1959 ARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEA 2018 Query: 486 ----------QDLSGQHQ-QELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCE 534 QDL Q Q+L LAQ E+ ++ER+Q + + R+ ++ + E Sbjct: 2019 LRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRV--QENMIQE 2076 Query: 535 LQSGNQQLEEQRV----ELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQ 590 Q+ Q+ EE+ + + V LQ L E +L T P + +SP + Sbjct: 2077 KQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE 2136 Query: 591 EPEK----EERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDLSLL 640 + K E R + + AL+ + E R++ L + + +S L Sbjct: 2137 QSLKLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSL 2190 Score = 79.0 bits (193), Expect = 2e-14 Identities = 103/405 (25%), Positives = 191/405 (47%), Gaps = 68/405 (16%) Query: 204 IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR---GL 260 ++ +Q E+Q++L+ + T +EQL + R E R E+ ++R L Sbjct: 682 LRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAAL 741 Query: 261 QEEHQAAELTRSKQQETVTRL-------EQSLSEAMEA-----LNREQESARLQQ--RER 306 + QA E R E + L E SL EA + + + Q ++Q + + Sbjct: 742 EVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAK 801 Query: 307 ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE 366 E ++ E + L L L+ E+ + ++ERDAA +E +T ALE+++ ++ Sbjct: 802 EVIQGEVRCLKLELDTERSQA---EQERDAAARQLAQAEQEGKT---ALEQQKAAHEKEV 855 Query: 367 HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426 +QL+E ++ + Q +L + E +RE E + +L Q+E+ ++ A+RE Sbjct: 856 NQLREKWEKERSWHQQELAKALESLEREKM---ELEMRLKEQQTEMEAIQ-----AQREE 907 Query: 427 DALQLEMSLVQARYESQR---------IQLESELAVQLEQRVTERLAQ--------AQES 469 + Q E +L Q + E+++ +Q + ELA +Q ERL Q QE+ Sbjct: 908 ERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQ--LERLRQDMKVQKLKEQET 965 Query: 470 SLRQAASLREHHRKQLQDLSGQHQQELA------SQLAQFKVEMAEREE--RQQQVAEDY 521 + L+E R +L++ + QH+ +LA S L Q K+++ ++ E + Q VA+D Sbjct: 966 TGILQTQLQEAQR-ELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDD 1024 Query: 522 ELRLARE--QARVCELQSGN---QQLEEQR----VELVERLQAML 557 RL + Q ++ E Q N ++LE ++ + L+E+ Q +L Sbjct: 1025 SQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLL 1069 Score = 77.8 bits (190), Expect = 4e-14 Identities = 115/530 (21%), Positives = 226/530 (42%), Gaps = 63/530 (11%) Query: 27 LNQVSSEVTSQLYASLRLSRQAEATARA----QLYLPSTSPPHEGLDGFAQELSRSLSVG 82 L Q+ E Q R ++ EA R ++ L + + L Q LS + + Sbjct: 710 LEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKEL- 768 Query: 83 LEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTA 142 LE +L + + E+ +GQL+ +QT T ++ + + E D+ S + Sbjct: 769 LESSLFEAQQQNSVIEV--TKGQLEVQIQTV--TQAKEVIQGEVRCLKLELDTERSQAEQ 824 Query: 143 TLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHT-RRKHCE 201 +D + AQA +E T+L + + LR+ + E + ++ Sbjct: 825 E-------RDAAARQLAQAEQE---GKTALEQQKAAHEKEVNQLREKWEKERSWHQQELA 874 Query: 202 RHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQ 261 + ++SL+ +EL+ +L +++ T +E + + E ERT+ L Sbjct: 875 KALESLEREKMELEMRL-------KEQQTEMEAIQA----------QREEERTQAESALC 917 Query: 262 EEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQ-RERET-------LEEER 313 + E R ET+ + ++ L++A + L R ++ ++Q+ +E+ET L+E + Sbjct: 918 QMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQ 977 Query: 314 QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHY 373 + L + LQEE + ++ +++E L++ L + + E +++E Sbjct: 978 RELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKL 1037 Query: 374 QALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEM 433 + QE ++ Q E E+EK+ L+L++ E R L + + R+++ L Sbjct: 1038 RETQEYNRIQKELEREKASL----------TLSLMEKEQRLLVLQEADSIRQQELSALRQ 1087 Query: 434 SLVQARYESQRIQLESELAVQLEQRVTERLAQ--AQESSLRQAASLREHHRKQLQDLSGQ 491 + +A+ E + + + EL L Q V E+ A AQE+ L + L H + Q + Sbjct: 1088 DMQEAQGEQKELSAQMEL---LRQEVKEKEADFLAQEAQLLE--ELEASHITEQQLRASL 1142 Query: 492 HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQ 541 QE + Q ++ E + + AE A+ QA++ L S QQ Sbjct: 1143 WAQEAKAAQLQLRLRSTE-SQLEALAAEQQPGNQAQAQAQLASLYSALQQ 1191 Score = 74.7 bits (182), Expect = 4e-13 Identities = 100/416 (24%), Positives = 180/416 (43%), Gaps = 45/416 (10%) Query: 224 ADRKKDTMIEQL----DKTLARVVEGWNR----HEAERTEVLRGLQEEHQAAELTRSKQQ 275 A+++ T +EQ +K + ++ E W + H+ E + L L+ E E+ R K+Q Sbjct: 836 AEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEM-RLKEQ 894 Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV---LQE 332 +T E +A R Q + L Q + ET +E L L+ +++ L+ Sbjct: 895 QT----EMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER 950 Query: 333 ERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQ 392 R + +L E L+ L+E ++ + Q ++ ALQEES + L+ +K Q Sbjct: 951 LRQDMKVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQ-DKMDLQ 1009 Query: 393 REAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELA 452 ++ + + + QL R +E E+ RE E + +Q E ++ L L Sbjct: 1010 KQVE---DLKSQLVAQDDSQRLVEQEVQEKLRETQ----EYNRIQKELEREKASLTLSL- 1061 Query: 453 VQLEQRV-----TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507 ++ EQR+ + + Q + S+LRQ + +K+L +QE+ + A F + Sbjct: 1062 MEKEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQE 1121 Query: 508 AER-EERQQQVAEDYELR--LAREQARVCELQ----SGNQQLE----EQRVELVERLQAM 556 A+ EE + + +LR L ++A+ +LQ S QLE EQ+ + QA Sbjct: 1122 AQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQ 1181 Query: 557 LQAHWDEANQLLSTTLPPPNPPAPPAGPSSP---GPQEPEKEERRVWTMPPMAVAL 609 L + + Q L + P G S+P G + + R ++ P+ AL Sbjct: 1182 LASLYSALQQALGSVC-ESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTAL 1236 Score = 70.9 bits (172), Expect = 5e-12 Identities = 94/380 (24%), Positives = 167/380 (43%), Gaps = 48/380 (12%) Query: 204 IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV--EGWNRHEAERTEVLRGL- 260 ++ L+T EL + A +++ ++Q+ K + +V+ EG N + E L Sbjct: 313 VEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLELD 372 Query: 261 -----QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQA 315 Q ++Q A+ + + +TR Q++ + + L QE+ L Q++ + EEE +A Sbjct: 373 SSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKA 432 Query: 316 LTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQA 375 L RL+ L ERD + E++ +L +ER+ + +L++ + Sbjct: 433 LRQRLQK-------LTGERDTLAGQTVDLQGEVD----SLSKERELLQKAREELRQQLEV 481 Query: 376 LQEES--------QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427 L++E+ + QL+ + + Q+E E Q +L L E RL+ L ++ Sbjct: 482 LEQEAWRLRRVNVELQLQGDSAQGQKE-----EQQEELHLAVRERERLQEMLMGLEAKQS 536 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQD 487 E+ ++ ES LE EL Q + VT LA+A E S+ + +S + ++ D Sbjct: 537 ESLSELITLREALESS--HLEGELLRQEQTEVTAALARA-EQSIAELSSSENTLKTEVAD 593 Query: 488 LSGQH------QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQ 541 L + LA ++ + EE Q V E A EQAR LQ + Sbjct: 594 LRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRME---AAEQARNA-LQVDLAE 649 Query: 542 LEEQRVELVER---LQAMLQ 558 E++R L E+ L+A LQ Sbjct: 650 AEKRREALWEKNTHLEAQLQ 669 Score = 62.4 bits (150), Expect = 2e-09 Identities = 124/574 (21%), Positives = 223/574 (38%), Gaps = 80/574 (13%) Query: 29 QVSSEVTSQLYASLRLSRQAEATARAQLYLPSTSP---PHEGLDGFAQELSRSLSVGLEK 85 ++ E Q+ SLR R E T + QL P + G + + L +K Sbjct: 1679 KILEEDLEQIKLSLR-ERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILR---DK 1734 Query: 86 NLKKKDGSKHIFEMESVRGQLQTMLQ--------TSRDTAYRDP---LIPGAGSERREED 134 + + +HI E++ ++ QL+ LQ TS + R+ ++ E RE+ Sbjct: 1735 EKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQG 1794 Query: 135 SFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEH 194 S + L+ + + Q LE L + L+ AL+ H Sbjct: 1795 ELKEQSLQSQLDEA---QRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAH 1851 Query: 195 TRRKHCERHIQSLQTRVLELQQQLAVAV--------------AADRKKDTMIEQLDKTLA 240 K +Q + + L+++LAV A R+++ + L + A Sbjct: 1852 MTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCA 1911 Query: 241 R-----------VVEGWNRHEA---ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS 286 + + W + +A ER + L L+ E Q++ + L+++L Sbjct: 1912 EQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALG 1971 Query: 287 EAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQE----ERDAARAGQL 342 +A AL +++ Q +LE L L+A Q L+E + + L Sbjct: 1972 KAHAALQGKEQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDL 2031 Query: 343 SEHRELETLRAAL--EEERQTWAQQEHQLKEHYQA-------LQEESQAQLEREKEKSQR 393 +++ L+ AL +E Q+ QL E A +QE+ ERE+E+ + Sbjct: 2032 RYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRG 2091 Query: 394 EAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV 453 Q+ E Q LA + E+ EL ++ + L S + E Q ++L+S Sbjct: 2092 LHQSVRELQLTLAQKEQEIL----ELRETQQRNNLEALPHSHKTSPMEEQSLKLDS---- 2143 Query: 454 QLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER 513 LE R+ L + Q ++LRQ + R++ QDL A LAQ K ++ +E Sbjct: 2144 -LEPRLQRELERLQ-AALRQTEAREIEWREKAQDL--------ALSLAQTKASVSSLQEV 2193 Query: 514 QQQVAEDYELRLAREQARVCELQSGNQQLEEQRV 547 + R + +Q EL+ + LE++R+ Sbjct: 2194 AMFLQASVLERDSEQQRLQDELELTRRALEKERL 2227 Score = 60.1 bits (144), Expect = 9e-09 Identities = 105/446 (23%), Positives = 181/446 (40%), Gaps = 102/446 (22%) Query: 207 LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH----EAERTEVLRGLQE 262 LQ +V +L+ QL + R ++EQ + R + +NR E E+ + L E Sbjct: 1008 LQKQVEDLKSQLVAQDDSQR----LVEQEVQEKLRETQEYNRIQKELEREKASLTLSLME 1063 Query: 263 EHQAAELTR---SKQQETVTRLEQSLSEAM---EALNREQESARLQQRERET--LEEERQ 314 + Q + + S +Q+ ++ L Q + EA + L+ + E R + +E+E L +E Q Sbjct: 1064 KEQRLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQ 1123 Query: 315 ALTLRLEA-----EQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369 L LEA +Q R + +E AA+ E + A E++ AQ + QL Sbjct: 1124 LLE-ELEASHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQL 1182 Query: 370 KEHYQALQEESQAQLEREKEKS--------------------------------QREAQA 397 Y ALQ+ + E E S EA A Sbjct: 1183 ASLYSALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVA 1242 Query: 398 A---------WETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQ----------A 438 + W+TQ +++ +V++LE L E+ + E+ +Q + Sbjct: 1243 SALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKS 1302 Query: 439 RYESQRIQLESE----------LAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDL 488 ++E ++ LESE L +L + +R+ E L QAA +E+ Q++ L Sbjct: 1303 KWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAA--KENLTAQVEHL 1360 Query: 489 -------------SGQHQQELASQLAQFKV---EMAEREERQQQVAEDYELRLAREQARV 532 +G +++L + + K+ E+ ER Q + E EL++A+ +A Sbjct: 1361 QAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420 Query: 533 CELQSGNQQLEEQRVELVERLQAMLQ 558 L Q L E R E VE L+ +Q Sbjct: 1421 ENLALLTQTLAE-REEEVETLRGQIQ 1445 Score = 47.0 bits (110), Expect = 8e-05 Identities = 86/360 (23%), Positives = 134/360 (37%), Gaps = 56/360 (15%) Query: 207 LQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQA 266 L+ +VL LQQQ+A AA +K L+ QE Q Sbjct: 20 LEEQVLALQQQMAENQAASWRK----------------------------LKNSQEAQQR 51 Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 K Q V + E + L E + QR E L +RLE EQQR Sbjct: 52 QATLVRKLQAKVLQYRSWCQELEKRL--EATGGPIPQRWENVEEPNLDELLVRLEEEQQR 109 Query: 327 CCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLER 386 C L E R + LR +E+ W++ +L +++ESQ Q+E+ Sbjct: 110 CESLAEVNTQLRLHMEKADVVNKALREDVEKLTVDWSRARDEL------MRKESQWQMEQ 163 Query: 387 EKEKSQREAQAAWETQHQLALVQSEV--RRLEGELDTARRERDALQLEMSLVQARYESQR 444 E K + E L+L + V RR E+ +A +RD ++L+ V R Sbjct: 164 EFFKGYLKG----EHGRLLSLWREVVTFRRHFLEMKSA-TDRDLMELKAEHV--RLSGSL 216 Query: 445 IQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504 + L V + R + Q L ++L+ + + QEL +Q Sbjct: 217 LTCCLRLTVGAQSREPNGSGRMDGREPAQLLLLLA-KTQELEKEAHERSQELIQLKSQGD 275 Query: 505 VEMAEREER----------QQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554 +E AE ++R Q+ EDYE + + V L++ + +L E L Q Sbjct: 276 LEKAELQDRVTELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQ 335 Score = 43.9 bits (102), Expect = 7e-04 Identities = 110/474 (23%), Positives = 186/474 (39%), Gaps = 59/474 (12%) Query: 38 LYASLRLSRQAE--ATARAQLYLPSTSPPHEGLDGFAQ------ELSRSLSVGLEKNLKK 89 L A + SR E A ARA+ + H L G Q ELSRSL Sbjct: 1945 LRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQAS 2004 Query: 90 KDGSK-HIFEMESV----RGQLQTM-LQTSRDTAYRDPLIPGAGSERR---EEDSFDSDS 140 D + H ++E G++Q L+ D + E R E + S Sbjct: 2005 LDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKS 2064 Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTR-RKH 199 A + +Q+ + EE+ + S+R L Q ++ L+ T+ R + Sbjct: 2065 LAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRE---LQLTLAQKEQEILELRETQQRNN 2121 Query: 200 CERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRG 259 E S +T +E Q K D++ +L + L R+ + EA E Sbjct: 2122 LEALPHSHKTSPMEEQSL---------KLDSLEPRLQRELERLQAALRQTEAREIE---- 2168 Query: 260 LQEEHQAAELTRSKQQETVTRLEQ-SLSEAMEALNREQESARLQQR---ERETLEEER-- 313 +E+ Q L+ ++ + +V+ L++ ++ L R+ E RLQ R LE+ER Sbjct: 2169 WREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLH 2228 Query: 314 ---QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQE---H 367 T L + ++ L E A + E ++ R LE +Q A+ E Sbjct: 2229 SPGATSTAELGSRGEQGVQLGEV-SGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRS 2287 Query: 368 QLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427 +L+ H L+ + Q+ERE+ K +REA A + E+ + T + R Sbjct: 2288 RLQRHNVQLRSTLE-QVERERRKLKREAMRAAQAG------SLEISKATASSPTQQDGRG 2340 Query: 428 ALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 + V A + + + L+++L ++ +Q+ AQ S R+ A L HH Sbjct: 2341 QKNSDAKCV-AELQKEVVLLQAQLTLERKQKQDYITRSAQTS--RELAGL--HH 2389 >gi|239745153 PREDICTED: similar to Putative golgin subfamily A member 6-like protein 6 [Homo sapiens] Length = 655 Score = 85.1 bits (209), Expect = 3e-16 Identities = 86/389 (22%), Positives = 178/389 (45%), Gaps = 34/389 (8%) Query: 205 QSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEH 264 + L+ + ELQ++L + + + ++ L + L ER ++L Q+ Sbjct: 214 EELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKL------------ERAQLLLPQQQLQ 261 Query: 265 QAAELTRSKQQETVTRLEQSL--SEAMEALNREQESARLQQRERETLEEER---QALTLR 319 A+ + Q +L+ + +E LN++QE +Q E+ +EE+ Q L +R Sbjct: 262 VEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321 Query: 320 LEAE----QQRCCVLQEERDAARAGQL--SEHRELETLRAALEEERQTWAQQE--HQLKE 371 + E Q+ QEE+ + ++ E + E E+E + W Q+E + E Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE 381 Query: 372 HYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQL 431 Q +EE Q E+ +E+ ++ + W + ++ ++R E E+ R+E +L Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEM--WRQEEKIREL 439 Query: 432 EMSL----VQARYESQRIQLESELAVQLE---QRVTERLAQAQESSLRQAASLREHHRKQ 484 E + + R +++Q E E + E QR E++ + +E + RQ L++ + Sbjct: 440 EEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499 Query: 485 LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544 Q+ Q+E + + E E+ +RQ++ + E+RL +++ ++ E + Q+LEE Sbjct: 500 EQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEE 559 Query: 545 QRVELVERLQAMLQAHWDEANQLLSTTLP 573 + +L ++ + + A + +Q L T P Sbjct: 560 RLGKLGQKAELLGGAGRESGSQRLPTLTP 588 Score = 64.7 bits (156), Expect = 4e-10 Identities = 58/295 (19%), Positives = 138/295 (46%), Gaps = 25/295 (8%) Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260 E I+ + ++ E ++++ R++D I++ ++ + R E E +R E + Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411 Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320 +++ + + +Q+E + R E+ + E E + ++E R + + + EE+ Q ++ Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI 471 Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEES 380 + ++++ + ++E R +L + E E+E + W +QE ++ E + +QE+ Sbjct: 472 QRQEEK--IQEQEEKTWRQEKLLKQEE-----KIWEQEEKMW-RQEEKMWEQEEKMQEQE 523 Query: 381 QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARY 440 + +++R++EK + + W+ + ++ + ++ LE L ++ + L Sbjct: 524 E-KMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELL----GGAGRES 578 Query: 441 ESQRI-QLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQ 494 SQR+ L L V+L+ + + L Q Q +H+R LQ +QQ Sbjct: 579 GSQRLPTLTPILQVELKSQEAQSLQQQQ-----------DHYRGHLQQYVAAYQQ 622 Score = 64.3 bits (155), Expect = 5e-10 Identities = 74/316 (23%), Positives = 146/316 (46%), Gaps = 40/316 (12%) Query: 226 RKKDTMIEQLDKTLARVVEGWNRHEA--ERTEVLRGLQEE----HQAAELTRSKQQETVT 279 R+++ + EQ +K + + W + E E+ E ++ +EE + K+QE + Sbjct: 350 RQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409 Query: 280 RLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARA 339 R E+ + E E + ++E Q+ + LEE Q +L +++ +QEE + + Sbjct: 410 RQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEK---MQEEEEKMQE 466 Query: 340 GQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAW 399 + R+ E ++ E+E +TW +QE LK QEE ++ ++EK R+ + W Sbjct: 467 QEEKIQRQEEKIQ---EQEEKTW-RQEKLLK------QEE---KIWEQEEKMWRQEEKMW 513 Query: 400 ETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRV 459 E + ++ + +++R E ++ RE+ ++ + + + + Q ++L Q + Sbjct: 514 EQEEKMQEQEEKMQRQEEKM----REQ---EVRLWQQEEKMQEQEVRL---------QEL 557 Query: 460 TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE--REERQQQV 517 ERL + + + + RE ++L L+ Q EL SQ AQ + + R QQ V Sbjct: 558 EERLGKLGQKAELLGGAGRESGSQRLPTLTPILQVELKSQEAQSLQQQQDHYRGHLQQYV 617 Query: 518 AEDYELRLAREQARVC 533 A +L +E C Sbjct: 618 AAYQQLASGKEALPSC 633 >gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] Length = 2115 Score = 84.7 bits (208), Expect = 3e-16 Identities = 120/504 (23%), Positives = 202/504 (40%), Gaps = 52/504 (10%) Query: 67 GLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGA 126 GL A+E L+ L++ + G +H ++E + L+ Q ++ A Sbjct: 523 GLKQQAKEKQAQLAQTLQQQEQASQGLRH--QVEQLSSSLKQKEQQLKEVA--------- 571 Query: 127 GSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGL 186 ++++ D L ++ S AL++L + Q Sbjct: 572 ----EKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVA 627 Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246 +A DS T +R L +V ELQ + A + + +L+ L Sbjct: 628 NEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQL------- 680 Query: 247 NRHEAERTEVLRGLQEEHQAAE-LTRSKQQETVTR--LEQSLSEAMEALNREQESARLQQ 303 + + TE R QE+ Q E L K+ VT+ LE+ A +AL +Q + Sbjct: 681 RSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELK 740 Query: 304 RERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWA 363 E +L E+ + LE E+ L+ AR QL E + ET L E Sbjct: 741 AETRSLVEQHKRERKELEEERAGRKGLE-----ARLQQLGEAHQAET--EVLRRELAEAM 793 Query: 364 QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTAR 423 +H + + L +E A ER ++ Q EAQ A+ Q ++ L+ E + AR Sbjct: 794 AAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYG-------AMFQEQLMTLKEECEKAR 846 Query: 424 RERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK 483 +E + +++ +++ E Q + ++ELA +L + L Q QE +R +K Sbjct: 847 QELQEAKEKVAGIESHSELQISRQQNELA-ELHANLARALQQVQEKEVRA--------QK 897 Query: 484 QLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLE 543 DLS ++ A+ ++E R+ +QQ E L +E AR + Q + LE Sbjct: 898 LADDLSTLQEKMAATSKEVARLETLVRKAGEQQ--ETASRELVKEPARAGDRQP--EWLE 953 Query: 544 EQRVELVERLQAMLQAHWDEANQL 567 EQ+ QA LQA EA Q+ Sbjct: 954 EQQGRQFCSTQAALQAMEREAEQM 977 Score = 84.3 bits (207), Expect = 5e-16 Identities = 100/418 (23%), Positives = 186/418 (44%), Gaps = 70/418 (16%) Query: 201 ERHIQSLQTRVLELQ---QQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVL 257 E + L +VLE + ++L V A+ +K +E+ + L + AER+ L Sbjct: 1231 EEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSAL 1290 Query: 258 R----GLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313 R L+EE + + ++ +T + E + L QE +++ TL+ E Sbjct: 1291 REEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEH 1350 Query: 314 ---QALTLRLEAEQQRCCVLQEERDAA------------------RAGQLSEHREL---- 348 QAL L + C LQ E+ AA RA L REL Sbjct: 1351 TSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELGELI 1410 Query: 349 ---------ETLRAALEEERQTWAQQEHQLKEHYQALQEES--------------QAQLE 385 E L E+ ++A+Q LK+ + L EE+ + +L+ Sbjct: 1411 PLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELD 1470 Query: 386 REKEKSQREAQAAW-ETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQR 444 + +EK +E A + + +LA VQ E + EL+ + + ++++ + R++ +R Sbjct: 1471 QAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530 Query: 445 IQLESELAVQLEQRVTERLAQAQESSLR-----QAASLREHHRKQLQDLSGQHQQE---L 496 +L +++ QLE E+ Q +E S + QA+ +++ K +Q G+ QQE L Sbjct: 1531 QKLTAQVE-QLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRL 1589 Query: 497 ASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554 +QL + + +++++E Q AE Y+L++ + + + NQ+L+EQ + +E+LQ Sbjct: 1590 QAQLNELQAQLSQKE----QAAEHYKLQMEKAKTHYDAKKQQNQELQEQ-LRSLEQLQ 1642 Score = 81.6 bits (200), Expect = 3e-15 Identities = 95/431 (22%), Positives = 174/431 (40%), Gaps = 32/431 (7%) Query: 150 LQDLSPSSSAQALEELFPRYTSLRPGPPL--NPPDFQGLRDALDSEH--------TRRKH 199 LQD P + L ++ T + L N Q + L++E R H Sbjct: 397 LQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERGH 456 Query: 200 CERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRG 259 E Q L + + +LQ I L + + + H A T + Sbjct: 457 FEEEKQQLSSLITDLQSS--------------ISNLSQAKEELEQASQAHGARLTAQVAS 502 Query: 260 LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLR 319 L E T +Q + + L+Q E L ++ + Q++ + L + + L+ Sbjct: 503 LTSELTTLNATIQQQDQELAGLKQQAKEKQAQL---AQTLQQQEQASQGLRHQVEQLSSS 559 Query: 320 LEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379 L+ ++Q+ + E+++A R + R A ER +Q L++ A E Sbjct: 560 LKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEI 619 Query: 380 SQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQAR 439 Q QL+ E + + Q + A + +V L+ ++TAR+E+ Q +++ ++ + Sbjct: 620 LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ 679 Query: 440 YES-QRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELAS 498 S Q+ E E Q + ++ E+L +ES SL E R+ L + QQ S Sbjct: 680 LRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADAL--EEQQRCIS 737 Query: 499 QLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQ-QLEEQRVELVERLQAML 557 +L + E+ +R+++ E+ +AR+ +L +Q + E R EL E + A Sbjct: 738 ELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQH 797 Query: 558 QAHWDEANQLL 568 A E QL+ Sbjct: 798 TAE-SECEQLV 807 Score = 71.6 bits (174), Expect = 3e-12 Identities = 98/412 (23%), Positives = 177/412 (42%), Gaps = 37/412 (8%) Query: 177 PLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAAD-------RKKD 229 PL P + + LRD +S R + Q L+T ++ +++ + R+ Sbjct: 272 PLEPKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFA 331 Query: 230 TMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAM 289 + ++QL L + E ++ E E L++E AA + +E L+ LS+ Sbjct: 332 SHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLE 391 Query: 290 EALNREQESARLQQRE-------RETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQL 342 E L++ Q++ ++ E ETL++E L Q R +L+ ER A L Sbjct: 392 EHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLL 451 Query: 343 SEHRELETLRAALEEERQTWA----QQEHQLKEHYQALQEESQAQLEREKEKSQREAQAA 398 +E R EEE+Q + + + QA +E QA + + A Sbjct: 452 AE-------RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLT 504 Query: 399 WETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQR 458 E A +Q + + L G L +E+ A QL +L Q SQ ++ + E QL Sbjct: 505 SELTTLNATIQQQDQELAG-LKQQAKEKQA-QLAQTLQQQEQASQGLRHQVE---QLSSS 559 Query: 459 VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK-VEMAEREERQQQV 517 + ++ Q +E + +Q A+ R+ H +QL + + + L + A K +E E+E+ + Sbjct: 560 LKQKEQQLKEVAEKQEAT-RQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLE 618 Query: 518 AEDYELRLAREQARVCELQSGNQQLEEQRVEL---VERLQAMLQAHWDEANQ 566 +L++A E Q+ Q + ++ EL VE LQA ++ E ++ Sbjct: 619 ILQQQLQVANEARD--SAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668 Score = 71.2 bits (173), Expect = 4e-12 Identities = 140/575 (24%), Positives = 233/575 (40%), Gaps = 99/575 (17%) Query: 49 EATARAQLYLPSTSPPHEGLDGFA---QELSRSLSV--GLEKNLKKKDG--SKHIFEMES 101 E ARA+L + + +E FA + L+ +L+ G ++ L K G + I E+E Sbjct: 1023 EKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEE 1082 Query: 102 VRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSSAQA 161 +R QT+ Q A ++ +E S + T P + Sbjct: 1083 LR---QTVKQLKEQLAKKE----------KEHASGSGAQSEAAGRTEP--------TGPK 1121 Query: 162 LEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVA 221 LE L + L L +L++E R + +++LQ ++ E Q+L + Sbjct: 1122 LEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHS 1181 Query: 222 ----------VAADRKK-DTMIEQLDKTLARVVEGWNRHEAERTEVL------------- 257 +AA R K + D+ A+V G R EAER L Sbjct: 1182 QSALASAQRELAAFRTKVQDHSKAEDEWKAQVARG--RQEAERKNSLISSLEEEVSILNR 1239 Query: 258 RGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERET-LEEERQAL 316 + L++E ++ EL R E+ Q L E + L E S + ER + L EE Q+L Sbjct: 1240 QVLEKEGESKELKRLVMAES--EKSQKLEERLRLLQAETASNSARAAERSSALREEVQSL 1297 Query: 317 TLRLEAEQQRCCV--LQEE--RDAARAGQLSEHRELETLRAALEEERQTWAQQEHQ---- 368 R EAE+QR L++E A RA +L + + + +E+ + Q EH Sbjct: 1298 --REEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQA 1355 Query: 369 -------LKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGEL-- 419 K Q LQ E A +R +E+ ++ QAA + +L Q E+ GEL Sbjct: 1356 LVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQREL----GELIP 1411 Query: 420 ---DTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAAS 476 A +ER A QL +A Y Q L+ + E+ L + A+ Sbjct: 1412 LRQKVAEQERTAQQLRAE--KASYAEQLSMLKKAHGLLAEEN----------RGLGERAN 1459 Query: 477 L-REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCEL 535 L R+ +L ++ QELA+ A + +AE + Q A + E+ A+ + ++ Sbjct: 1460 LGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKV 1519 Query: 536 QSGNQQLEEQRVEL---VERLQAMLQAHWDEANQL 567 Q+ +E+R +L VE+L+ + + +L Sbjct: 1520 LEERQRFQEERQKLTAQVEQLEVFQREQTKQVEEL 1554 Score = 67.8 bits (164), Expect = 4e-11 Identities = 81/340 (23%), Positives = 149/340 (43%), Gaps = 57/340 (16%) Query: 274 QQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEE 333 +++ + Q + + LN +Q ++ L+ +E E L ++ ++LT+RL ++C L+ E Sbjct: 246 EKDAQIAMMQQRIDRLALLNEKQAASPLEPKELEELRDKNESLTMRLHETLKQCQDLKTE 305 Query: 334 RDA--ARAGQLSEHR-ELE-TLRAALEEERQTWAQQEHQLKEHYQALQE--ESQAQLERE 387 + + QLSE +L LR +Q +EH +A QE E QAQLE+E Sbjct: 306 KSQMDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKE 365 Query: 388 -----------KEKSQREAQAAWETQHQLALVQSEVRRLEGE-------LDTARRERDAL 429 +EK++ + + L+ +Q + +GE L+T ++E L Sbjct: 366 LSAALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATL 425 Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE--------SSLRQAASLREHH 481 + +QAR E LE+E Q + + ER +E + L+ + S Sbjct: 426 AANNTQLQARVE----MLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQA 481 Query: 482 RKQLQDLSGQHQQELASQLAQFKVEMA------------------EREERQQQVAEDYEL 523 +++L+ S H L +Q+A E+ + +E+Q Q+A+ + Sbjct: 482 KEELEQASQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQ 541 Query: 524 RLAREQA---RVCELQSGNQQLEEQRVELVERLQAMLQAH 560 + Q +V +L S +Q E+Q E+ E+ +A Q H Sbjct: 542 QEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDH 581 Score = 65.5 bits (158), Expect = 2e-10 Identities = 135/581 (23%), Positives = 235/581 (40%), Gaps = 89/581 (15%) Query: 39 YASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFE 98 ++ L++SRQ A L + + AQ+L+ LS EK SK + Sbjct: 862 HSELQISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT---SKEVAR 918 Query: 99 MESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQDLSPSSS 158 +E++ + +T+ ++P G +R+ E L + Q S ++ Sbjct: 919 LETLVRKAGEQQETASRELVKEPARAG---DRQPE---------WLEEQQGRQFCSTQAA 966 Query: 159 AQALEELFPRYTSLRPGPPLNPPDFQGLRDAL----DSEHTRRKHCERHIQSLQTRVLEL 214 QA+E + + + + LR AL + R ER + L Sbjct: 967 LQAMEREAEQMGN----------ELERLRAALMESQGQQQEERGQQEREVARLTQERGRA 1016 Query: 215 QQQLAVAVAAD-----RKKDTMIEQ------LDKTLARVVEGWNRHEAERTEVLRGLQEE 263 Q LA+ AA R ++ + EQ L + LA + + E + LRGL E Sbjct: 1017 QADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAK-LRGL-EA 1074 Query: 264 HQAAELTRSKQQETVTRLEQSLS----EAMEALNREQESARLQQR---ERETLEEERQAL 316 Q EL +Q TV +L++ L+ E + E+A + + E L E L Sbjct: 1075 AQIKELEELRQ--TVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKL 1132 Query: 317 TLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQ---------TWAQQE- 366 + + +Q++ L+ +A RA + LETL+ LEE+ Q AQ+E Sbjct: 1133 EQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQREL 1192 Query: 367 ----HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTA 422 ++++H +A ++E +AQ+ R +++++R+ + +++++ +V EGE Sbjct: 1193 AAFRTKVQDHSKA-EDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKEL 1251 Query: 423 RRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLR-QAASLREHH 481 +R LV A E + E +Q E A + S+LR + SLRE Sbjct: 1252 KR----------LVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEA 1301 Query: 482 RKQ-------LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCE 534 KQ Q+L+ Q E A +L Q E+ +++Q +L QA V E Sbjct: 1302 EKQRVASENLRQELTS--QAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSE 1359 Query: 535 LQSGN---QQLEEQRVELVERLQAMLQAHWDEANQLLSTTL 572 L QQL+ ++ +R + L+ A L + L Sbjct: 1360 LLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELL 1400 Score = 46.2 bits (108), Expect = 1e-04 Identities = 47/186 (25%), Positives = 88/186 (47%), Gaps = 33/186 (17%) Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQE 468 Q ++RRL+ +L R RD L+LE++ E++++ E + + + Q+ +RLA E Sbjct: 213 QFQMRRLKKQLADERSNRDELELELA------ENRKLLTEKDAQIAMMQQRIDRLALLNE 266 Query: 469 SSLRQAASLREHHRKQLQDLSGQHQ------QELASQLAQFKVEMAEREERQQQVAE--- 519 +QAAS E K+L++L +++ E Q K E ++ + + Q++E Sbjct: 267 ---KQAASPLE--PKELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENG 321 Query: 520 DYELRLAREQARVCELQSGNQQLEEQ-----------RVELVERLQAMLQAH--WDEANQ 566 D +L + + +LQ +L E+ + +L + L A LQ +E N+ Sbjct: 322 DLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNE 381 Query: 567 LLSTTL 572 +L L Sbjct: 382 ILQGKL 387 Score = 45.8 bits (107), Expect = 2e-04 Identities = 57/278 (20%), Positives = 122/278 (43%), Gaps = 62/278 (22%) Query: 201 ERHIQSL-------QTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253 E+++Q L +TR+ E+Q++ A + R+ + M + + +V+E R + ER Sbjct: 1474 EKYVQELAAVRADAETRLAEVQRE---AQSTARELEVMTAKYEGAKVKVLEERQRFQEER 1530 Query: 254 TEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEER 313 ++ +++ E+ + +Q + V L + L+++ +A +Q+ + Q + ++E Sbjct: 1531 QKLTAQVEQ----LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEA 1586 Query: 314 QALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHY 373 Q L +L Q + L ++ AA EH +L+ +A K HY Sbjct: 1587 QRLQAQLNELQAQ---LSQKEQAA------EHYKLQMEKA----------------KTHY 1621 Query: 374 QALQEESQ---------AQLEREKEKSQREAQAAWETQHQLAL-----------VQSEVR 413 A ++++Q QL++E ++ + EA+ Q L + ++VR Sbjct: 1622 DAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVR 1681 Query: 414 RLEGEL---DTARRERDALQLEMSLVQARYESQRIQLE 448 LE ++ D R+ Q+ +++R + QL+ Sbjct: 1682 SLEAQVAHADQQLRDLGKFQVATDALKSREPQAKPQLD 1719 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 83.6 bits (205), Expect = 8e-16 Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%) Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200 T LL Q L+ S+ + LEE + L+D LD E +++ Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1362 Query: 201 ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228 ERHI +L Q + L QQ AA ++ K Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422 Query: 229 DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275 + + ++LD L + +++ AE + +E AE +++ Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482 Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321 L ++L EA+EA + + ++ + E E L E+ ++AL ++E Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542 Query: 322 AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381 + + L++E A +L ++ L+ E + Q +Q + + Q E + Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602 Query: 382 AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420 +LE E+++ A A E QL +Q++++ + EL+ Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662 Query: 421 TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472 AR RD A E E+ +QL+ +LA R E LA+ SSL Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722 Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532 +L++ R+ L+ Q ++EL + + M++R + Q AE LA E++ Sbjct: 1723 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1780 Query: 533 CELQSGNQQLEEQRVELVERLQAM 556 + +S QQLE Q EL +L M Sbjct: 1781 QKNESARQQLERQNKELRSKLHEM 1804 Score = 72.0 bits (175), Expect = 2e-12 Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251 R E + +T+ L L + L A+ A + + + L + +V G N HE Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530 Query: 252 ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299 E+++ L L++E QA E + + + + L+ ++A + + E Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590 Query: 300 RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340 R Q + E ET LE+ER+ L A+++ L++ + D+A G Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650 Query: 341 --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394 Q+ + RELE RA+ +E T + E + K LQE+ A K+ + Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710 Query: 395 AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451 + A E L+ +Q E RRLE + E + Q M + S R++ ++ Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1765 Query: 452 AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509 A QL + TER AQ ES+ +Q + R +L ++ G + + S +A + ++A+ Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825 Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566 EE+ +Q A + +QA L+ +++L+E ++ VE + M + + ++A + Sbjct: 1826 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1874 Score = 69.7 bits (169), Expect = 1e-11 Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%) Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 + Q LD E ++ + + I+ L+ + +LQ+ L AA K + L + L Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1148 Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301 EA +TE+ L EL R+K+++ VT L+++L E E + E + + Sbjct: 1149 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1197 Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361 +Q+ + +EE + L E+ A+A + LE A L E + Sbjct: 1198 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1242 Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421 Q + +++ + L+ AQ++ + K +A E ++ +Q+EV + G L+ Sbjct: 1243 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298 Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 A + L +++ + ++ + + L+ E +L V+ +L Q +E Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1344 Query: 482 RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R LQD + +Q L ++ +++++ +++ Q A E ++ E+++ Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404 Query: 539 NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585 QQ EE+ + +E+ + LQ D+ QL+S A S Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464 Query: 586 SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637 S E ++ E A++L L+++ EA++EL +L + DL Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516 Score = 68.6 bits (166), Expect = 3e-11 Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L+ E R + + + + ++L+L++QL AA +K QL+K A Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 976 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 EA+ ++ L++E + +K + LE+ +S+ L E+E A+ + + Sbjct: 977 EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369 E L +RL+ E++ L++ + H ++ L+A + E + A++E Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1089 Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429 EE QA L R ++ ++ A ++ ++ + L+ +LD+ R R+ Sbjct: 1090 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1137 Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488 + + + E+ + +LE L Q+ + + + L++A H Q+Q++ Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197 Query: 489 SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528 +H Q EL QL QFK A ++ +Q Q ++ E + + Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257 Query: 529 QARVCELQSGNQQLEEQRVELVERLQAM 556 +A+V ELQS E R EL +++ + Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKL 1285 Score = 67.0 bits (162), Expect = 7e-11 Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%) Query: 272 SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331 ++Q+E + E L + E + + + +++ L EE+ L +L+AE + + Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907 Query: 332 EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391 E R A + L + A LEEE Q + + K + +Q L+ E++ Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 960 Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449 + EA A + Q + ++++++LE E+ + + L E L++ R L E Sbjct: 961 EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019 Query: 450 ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501 E A L + + + E +R L + RK D S H+Q +L +Q+A Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079 Query: 502 QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544 + K+++A++EE Q + +A++ + + +LQ + + E+ Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139 Query: 545 QRVELVERLQAM 556 Q+ +L E L+A+ Sbjct: 1140 QKRDLGEELEAL 1151 Score = 66.2 bits (160), Expect = 1e-10 Identities = 111/537 (20%), Positives = 222/537 (41%), Gaps = 79/537 (14%) Query: 36 SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92 S YA R +AEA + L E L+ +EL R+ L +E + KD Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1522 Query: 93 -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151 K++ E+E + L+T ++ + E +E D+ L Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1565 Query: 152 DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211 + QAL+ F R D Q RD + E +R+ +R + +T + Sbjct: 1566 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1605 Query: 212 LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266 + ++Q A+A AA +K + ++ L+ ++G R EA + ++ Q E + Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1663 Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 A +R + T E+ L + QE +R R+ + E++ L L + Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723 Query: 327 CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377 LQ+E R AR QL E E +E + + + Q Q ++L Q Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783 Query: 378 EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432 E ++ QLER+ ++ + E + A +++ + +A +++++ +LE +++ RE+ A Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843 Query: 433 MSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQH 492 + + + +Q+E E+++ E+ + E + L ++QL++ + + Sbjct: 1844 LKQKDKKLKEILLQVED------ERKMAEQYKEQAEKGNARVKQL----KRQLEE-AEEE 1892 Query: 493 QQELASQLAQFKVEMAEREERQQQVAEDY-----ELRLAREQARVCELQSGNQQLEE 544 Q + + + + E+ E E + + + +LR E + V +SG +++ E Sbjct: 1893 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1949 Score = 65.1 bits (157), Expect = 3e-10 Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%) Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329 T+ K VTR E+ + + L + +E + + E + LE++ LT Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 886 Query: 330 LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388 EE++ L E + ET L A EE R A ++ +L+E + E +A+LE E+ Sbjct: 887 --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 935 Query: 389 EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448 ++ Q + Q + + ++ LE +L+ R LQLE +A+ + +LE Sbjct: 936 DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 984 Query: 449 SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504 E+ V +Q +L + + S L + E K L L +H+ S +++ + Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1040 Query: 505 VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560 V + ++EE+ +Q E + +L + + ++ +LQ+ +L+ Q + E LQA L Sbjct: 1041 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099 Query: 561 WDEANQ 566 DE Q Sbjct: 1100 DDEIAQ 1105 Score = 60.1 bits (144), Expect = 9e-09 Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%) Query: 255 EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304 E ++ ++E Q + + K + + LEQ S+ E N QE + + Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911 Query: 305 ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354 +++ LEE + RLE E+ R LQ ER L +LE AA Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971 Query: 355 -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400 LE+E Q ++L + + L+E + L E+EK++ + + Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1029 Query: 401 TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455 +H+ + + EVR + EL+ +R+ + + A ++Q +L+ +LA + Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089 Query: 456 EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500 E+ R+ + +AQ + ++L++ L H +DL + +++L +L Sbjct: 1090 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148 Query: 501 AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560 K E+ E+ A ELR REQ E+ + L+E+ ++Q M Q H Sbjct: 1149 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1201 Query: 561 WDEANQL 567 +L Sbjct: 1202 AQAVEEL 1208 Score = 43.9 bits (102), Expect = 7e-04 Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%) Query: 344 EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403 + E++ L++ ++ + E++LKE E+ +QL EK Q + QA E Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 901 Query: 404 QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463 + +E + L ++E + + EM E + QL++E +Q + Sbjct: 902 ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957 Query: 464 AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509 +E + RQ L E K+L+D + ++ L +++ +AE Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017 Query: 510 REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559 EE + + + + E+RL +E+ EL+ ++LE + E++ A LQA Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1076 Query: 560 HWDEANQLLS 569 E L+ Sbjct: 1077 QIAELKMQLA 1086 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 83.6 bits (205), Expect = 8e-16 Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%) Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200 T LL Q L+ S+ + LEE + L+D LD E +++ Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1369 Query: 201 ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228 ERHI +L Q + L QQ AA ++ K Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429 Query: 229 DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275 + + ++LD L + +++ AE + +E AE +++ Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489 Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321 L ++L EA+EA + + ++ + E E L E+ ++AL ++E Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549 Query: 322 AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381 + + L++E A +L ++ L+ E + Q +Q + + Q E + Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609 Query: 382 AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420 +LE E+++ A A E QL +Q++++ + EL+ Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669 Query: 421 TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472 AR RD A E E+ +QL+ +LA R E LA+ SSL Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729 Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532 +L++ R+ L+ Q ++EL + + M++R + Q AE LA E++ Sbjct: 1730 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1787 Query: 533 CELQSGNQQLEEQRVELVERLQAM 556 + +S QQLE Q EL +L M Sbjct: 1788 QKNESARQQLERQNKELRSKLHEM 1811 Score = 72.0 bits (175), Expect = 2e-12 Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251 R E + +T+ L L + L A+ A + + + L + +V G N HE Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537 Query: 252 ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299 E+++ L L++E QA E + + + + L+ ++A + + E Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597 Query: 300 RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340 R Q + E ET LE+ER+ L A+++ L++ + D+A G Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657 Query: 341 --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394 Q+ + RELE RA+ +E T + E + K LQE+ A K+ + Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717 Query: 395 AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451 + A E L+ +Q E RRLE + E + Q M + S R++ ++ Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1772 Query: 452 AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509 A QL + TER AQ ES+ +Q + R +L ++ G + + S +A + ++A+ Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832 Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566 EE+ +Q A + +QA L+ +++L+E ++ VE + M + + ++A + Sbjct: 1833 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1881 Score = 69.7 bits (169), Expect = 1e-11 Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%) Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 + Q LD E ++ + + I+ L+ + +LQ+ L AA K + L + L Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1155 Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301 EA +TE+ L EL R+K+++ VT L+++L E E + E + + Sbjct: 1156 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1204 Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361 +Q+ + +EE + L E+ A+A + LE A L E + Sbjct: 1205 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1249 Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421 Q + +++ + L+ AQ++ + K +A E ++ +Q+EV + G L+ Sbjct: 1250 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305 Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 A + L +++ + ++ + + L+ E +L V+ +L Q +E Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1351 Query: 482 RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R LQD + +Q L ++ +++++ +++ Q A E ++ E+++ Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411 Query: 539 NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585 QQ EE+ + +E+ + LQ D+ QL+S A S Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471 Query: 586 SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637 S E ++ E A++L L+++ EA++EL +L + DL Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523 Score = 68.6 bits (166), Expect = 3e-11 Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L+ E R + + + + ++L+L++QL AA +K QL+K A Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 983 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 EA+ ++ L++E + +K + LE+ +S+ L E+E A+ + + Sbjct: 984 EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369 E L +RL+ E++ L++ + H ++ L+A + E + A++E Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1096 Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429 EE QA L R ++ ++ A ++ ++ + L+ +LD+ R R+ Sbjct: 1097 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1144 Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488 + + + E+ + +LE L Q+ + + + L++A H Q+Q++ Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204 Query: 489 SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528 +H Q EL QL QFK A ++ +Q Q ++ E + + Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264 Query: 529 QARVCELQSGNQQLEEQRVELVERLQAM 556 +A+V ELQS E R EL +++ + Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKL 1292 Score = 67.0 bits (162), Expect = 7e-11 Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%) Query: 272 SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331 ++Q+E + E L + E + + + +++ L EE+ L +L+AE + + Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914 Query: 332 EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391 E R A + L + A LEEE Q + + K + +Q L+ E++ Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 967 Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449 + EA A + Q + ++++++LE E+ + + L E L++ R L E Sbjct: 968 EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026 Query: 450 ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501 E A L + + + E +R L + RK D S H+Q +L +Q+A Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086 Query: 502 QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544 + K+++A++EE Q + +A++ + + +LQ + + E+ Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146 Query: 545 QRVELVERLQAM 556 Q+ +L E L+A+ Sbjct: 1147 QKRDLGEELEAL 1158 Score = 66.2 bits (160), Expect = 1e-10 Identities = 111/537 (20%), Positives = 222/537 (41%), Gaps = 79/537 (14%) Query: 36 SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92 S YA R +AEA + L E L+ +EL R+ L +E + KD Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1529 Query: 93 -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151 K++ E+E + L+T ++ + E +E D+ L Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1572 Query: 152 DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211 + QAL+ F R D Q RD + E +R+ +R + +T + Sbjct: 1573 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1612 Query: 212 LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266 + ++Q A+A AA +K + ++ L+ ++G R EA + ++ Q E + Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1670 Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 A +R + T E+ L + QE +R R+ + E++ L L + Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730 Query: 327 CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377 LQ+E R AR QL E E +E + + + Q Q ++L Q Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790 Query: 378 EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432 E ++ QLER+ ++ + E + A +++ + +A +++++ +LE +++ RE+ A Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850 Query: 433 MSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQH 492 + + + +Q+E E+++ E+ + E + L ++QL++ + + Sbjct: 1851 LKQKDKKLKEILLQVED------ERKMAEQYKEQAEKGNARVKQL----KRQLEE-AEEE 1899 Query: 493 QQELASQLAQFKVEMAEREERQQQVAEDY-----ELRLAREQARVCELQSGNQQLEE 544 Q + + + + E+ E E + + + +LR E + V +SG +++ E Sbjct: 1900 SQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNETSFVPSRRSGGRRVIE 1956 Score = 65.1 bits (157), Expect = 3e-10 Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%) Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329 T+ K VTR E+ + + L + +E + + E + LE++ LT Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 893 Query: 330 LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388 EE++ L E + ET L A EE R A ++ +L+E + E +A+LE E+ Sbjct: 894 --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 942 Query: 389 EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448 ++ Q + Q + + ++ LE +L+ R LQLE +A+ + +LE Sbjct: 943 DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 991 Query: 449 SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504 E+ V +Q +L + + S L + E K L L +H+ S +++ + Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1047 Query: 505 VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560 V + ++EE+ +Q E + +L + + ++ +LQ+ +L+ Q + E LQA L Sbjct: 1048 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106 Query: 561 WDEANQ 566 DE Q Sbjct: 1107 DDEIAQ 1112 Score = 60.1 bits (144), Expect = 9e-09 Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%) Query: 255 EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304 E ++ ++E Q + + K + + LEQ S+ E N QE + + Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918 Query: 305 ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354 +++ LEE + RLE E+ R LQ ER L +LE AA Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978 Query: 355 -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400 LE+E Q ++L + + L+E + L E+EK++ + + Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1036 Query: 401 TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455 +H+ + + EVR + EL+ +R+ + + A ++Q +L+ +LA + Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096 Query: 456 EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500 E+ R+ + +AQ + ++L++ L H +DL + +++L +L Sbjct: 1097 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155 Query: 501 AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560 K E+ E+ A ELR REQ E+ + L+E+ ++Q M Q H Sbjct: 1156 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1208 Query: 561 WDEANQL 567 +L Sbjct: 1209 AQAVEEL 1215 Score = 43.9 bits (102), Expect = 7e-04 Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%) Query: 344 EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403 + E++ L++ ++ + E++LKE E+ +QL EK Q + QA E Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 908 Query: 404 QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463 + +E + L ++E + + EM E + QL++E +Q + Sbjct: 909 ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964 Query: 464 AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509 +E + RQ L E K+L+D + ++ L +++ +AE Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024 Query: 510 REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559 EE + + + + E+RL +E+ EL+ ++LE + E++ A LQA Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1083 Query: 560 HWDEANQLLS 569 E L+ Sbjct: 1084 QIAELKMQLA 1093 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 83.6 bits (205), Expect = 8e-16 Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%) Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200 T LL Q L+ S+ + LEE + L+D LD E +++ Sbjct: 1327 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1369 Query: 201 ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228 ERHI +L Q + L QQ AA ++ K Sbjct: 1370 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1429 Query: 229 DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275 + + ++LD L + +++ AE + +E AE +++ Sbjct: 1430 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1489 Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321 L ++L EA+EA + + ++ + E E L E+ ++AL ++E Sbjct: 1490 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1549 Query: 322 AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381 + + L++E A +L ++ L+ E + Q +Q + + Q E + Sbjct: 1550 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609 Query: 382 AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420 +LE E+++ A A E QL +Q++++ + EL+ Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1669 Query: 421 TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472 AR RD A E E+ +QL+ +LA R E LA+ SSL Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1729 Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532 +L++ R+ L+ Q ++EL + + M++R + Q AE LA E++ Sbjct: 1730 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1787 Query: 533 CELQSGNQQLEEQRVELVERLQAM 556 + +S QQLE Q EL +L M Sbjct: 1788 QKNESARQQLERQNKELRSKLHEM 1811 Score = 72.0 bits (175), Expect = 2e-12 Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251 R E + +T+ L L + L A+ A + + + L + +V G N HE Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1537 Query: 252 ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299 E+++ L L++E QA E + + + + L+ ++A + + E Sbjct: 1538 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1597 Query: 300 RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340 R Q + E ET LE+ER+ L A+++ L++ + D+A G Sbjct: 1598 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1657 Query: 341 --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394 Q+ + RELE RA+ +E T + E + K LQE+ A K+ + Sbjct: 1658 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1717 Query: 395 AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451 + A E L+ +Q E RRLE + E + Q M + S R++ ++ Sbjct: 1718 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1772 Query: 452 AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509 A QL + TER AQ ES+ +Q + R +L ++ G + + S +A + ++A+ Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1832 Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566 EE+ +Q A + +QA L+ +++L+E ++ VE + M + + ++A + Sbjct: 1833 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1881 Score = 70.1 bits (170), Expect = 9e-12 Identities = 82/391 (20%), Positives = 163/391 (41%), Gaps = 61/391 (15%) Query: 77 RSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTML---QTSRDTAYRDPLIPGAGSERREE 133 ++L E++L+ +D E R QLQ L +T + + + A ++ E Sbjct: 1577 QALKGQFERDLQARDEQN-----EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631 Query: 134 DSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSE 193 D D + L S+ + EE + L+ + + R + D Sbjct: 1632 DLKDLE-------------LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678 Query: 194 HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253 K E+ +SL+ +++LQ+ LA A A ++ D E+L + LA + G N + E+ Sbjct: 1679 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1738 Query: 254 TEV---LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLE 310 + + L+EE + + + V + Q + L E+ +A+ + R+ LE Sbjct: 1739 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1798 Query: 311 EERQALTLRLE---------------AEQQRCCVLQE-------ERDAARAGQLSEHREL 348 + + L +L A + + L+E E+ AA + ++L Sbjct: 1799 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1858 Query: 349 ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408 + + +E+ER+ A+Q + E A ++ + QLE +E+SQR + Sbjct: 1859 KEILLQVEDERKM-AEQYKEQAEKGNARVKQLKRQLEEAEEESQR--------------I 1903 Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQAR 439 + R+L+ ELD A +A+ E++ ++++ Sbjct: 1904 NANRRKLQRELDEATESNEAMGREVNALKSK 1934 Score = 69.7 bits (169), Expect = 1e-11 Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%) Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 + Q LD E ++ + + I+ L+ + +LQ+ L AA K + L + L Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1155 Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301 EA +TE+ L EL R+K+++ VT L+++L E E + E + + Sbjct: 1156 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1204 Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361 +Q+ + +EE + L E+ A+A + LE A L E + Sbjct: 1205 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1249 Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421 Q + +++ + L+ AQ++ + K +A E ++ +Q+EV + G L+ Sbjct: 1250 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1305 Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 A + L +++ + ++ + + L+ E +L V+ +L Q +E Sbjct: 1306 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1351 Query: 482 RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R LQD + +Q L ++ +++++ +++ Q A E ++ E+++ Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1411 Query: 539 NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585 QQ EE+ + +E+ + LQ D+ QL+S A S Sbjct: 1412 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1471 Query: 586 SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637 S E ++ E A++L L+++ EA++EL +L + DL Sbjct: 1472 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1523 Score = 68.6 bits (166), Expect = 3e-11 Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L+ E R + + + + ++L+L++QL AA +K QL+K A Sbjct: 938 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 983 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 EA+ ++ L++E + +K + LE+ +S+ L E+E A+ + + Sbjct: 984 EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1039 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369 E L +RL+ E++ L++ + H ++ L+A + E + A++E Sbjct: 1040 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1096 Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429 EE QA L R ++ ++ A ++ ++ + L+ +LD+ R R+ Sbjct: 1097 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1144 Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488 + + + E+ + +LE L Q+ + + + L++A H Q+Q++ Sbjct: 1145 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1204 Query: 489 SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528 +H Q EL QL QFK A ++ +Q Q ++ E + + Sbjct: 1205 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1264 Query: 529 QARVCELQSGNQQLEEQRVELVERLQAM 556 +A+V ELQS E R EL +++ + Sbjct: 1265 EAQVQELQSKCSDGERARAELNDKVHKL 1292 Score = 67.0 bits (162), Expect = 7e-11 Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%) Query: 272 SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331 ++Q+E + E L + E + + + +++ L EE+ L +L+AE + + Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914 Query: 332 EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391 E R A + L + A LEEE Q + + K + +Q L+ E++ Sbjct: 915 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 967 Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449 + EA A + Q + ++++++LE E+ + + L E L++ R L E Sbjct: 968 EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1026 Query: 450 ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501 E A L + + + E +R L + RK D S H+Q +L +Q+A Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1086 Query: 502 QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544 + K+++A++EE Q + +A++ + + +LQ + + E+ Sbjct: 1087 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1146 Query: 545 QRVELVERLQAM 556 Q+ +L E L+A+ Sbjct: 1147 QKRDLGEELEAL 1158 Score = 65.1 bits (157), Expect = 3e-10 Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%) Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329 T+ K VTR E+ + + L + +E + + E + LE++ LT Sbjct: 846 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 893 Query: 330 LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388 EE++ L E + ET L A EE R A ++ +L+E + E +A+LE E+ Sbjct: 894 --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 942 Query: 389 EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448 ++ Q + Q + + ++ LE +L+ R LQLE +A+ + +LE Sbjct: 943 DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 991 Query: 449 SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504 E+ V +Q +L + + S L + E K L L +H+ S +++ + Sbjct: 992 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1047 Query: 505 VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560 V + ++EE+ +Q E + +L + + ++ +LQ+ +L+ Q + E LQA L Sbjct: 1048 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106 Query: 561 WDEANQ 566 DE Q Sbjct: 1107 DDEIAQ 1112 Score = 64.7 bits (156), Expect = 4e-10 Identities = 105/483 (21%), Positives = 201/483 (41%), Gaps = 75/483 (15%) Query: 36 SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92 S YA R +AEA + L E L+ +EL R+ L +E + KD Sbjct: 1471 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1529 Query: 93 -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151 K++ E+E + L+T ++ + E +E D+ L Sbjct: 1530 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1572 Query: 152 DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211 + QAL+ F R D Q RD + E +R+ +R + +T + Sbjct: 1573 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1612 Query: 212 LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266 + ++Q A+A AA +K + ++ L+ ++G R EA + ++ Q E + Sbjct: 1613 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1670 Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 A +R + T E+ L + QE +R R+ + E++ L L + Sbjct: 1671 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1730 Query: 327 CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377 LQ+E R AR QL E E +E + + + Q Q ++L Q Sbjct: 1731 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1790 Query: 378 EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432 E ++ QLER+ ++ + E + A +++ + +A +++++ +LE +++ RE+ A Sbjct: 1791 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1850 Query: 433 MSLVQARYESQRIQLESE--LAVQLEQ----------RVTERLAQAQESSLRQAASLREH 480 + + + +Q+E E +A Q ++ ++ +L +A+E S R A+ R+ Sbjct: 1851 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1910 Query: 481 HRK 483 R+ Sbjct: 1911 QRE 1913 Score = 60.1 bits (144), Expect = 9e-09 Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%) Query: 255 EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304 E ++ ++E Q + + K + + LEQ S+ E N QE + + Sbjct: 859 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 918 Query: 305 ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354 +++ LEE + RLE E+ R LQ ER L +LE AA Sbjct: 919 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 978 Query: 355 -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400 LE+E Q ++L + + L+E + L E+EK++ + + Sbjct: 979 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1036 Query: 401 TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455 +H+ + + EVR + EL+ +R+ + + A ++Q +L+ +LA + Sbjct: 1037 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1096 Query: 456 EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500 E+ R+ + +AQ + ++L++ L H +DL + +++L +L Sbjct: 1097 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1155 Query: 501 AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560 K E+ E+ A ELR REQ E+ + L+E+ ++Q M Q H Sbjct: 1156 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1208 Query: 561 WDEANQL 567 +L Sbjct: 1209 AQAVEEL 1215 Score = 43.9 bits (102), Expect = 7e-04 Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%) Query: 344 EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403 + E++ L++ ++ + E++LKE E+ +QL EK Q + QA E Sbjct: 857 QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 908 Query: 404 QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463 + +E + L ++E + + EM E + QL++E +Q + Sbjct: 909 ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 964 Query: 464 AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509 +E + RQ L E K+L+D + ++ L +++ +AE Sbjct: 965 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1024 Query: 510 REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559 EE + + + + E+RL +E+ EL+ ++LE + E++ A LQA Sbjct: 1025 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1083 Query: 560 HWDEANQLLS 569 E L+ Sbjct: 1084 QIAELKMQLA 1093 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 83.6 bits (205), Expect = 8e-16 Identities = 110/504 (21%), Positives = 194/504 (38%), Gaps = 107/504 (21%) Query: 141 TATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHC 200 T LL Q L+ S+ + LEE + L+D LD E +++ Sbjct: 1320 TQELLQEETRQKLNVSTKLRQLEE-----------------ERNSLQDQLDEEMEAKQNL 1362 Query: 201 ERHIQSL----------------------------QTRVLELQQQLAVAVAA----DRKK 228 ERHI +L Q + L QQ AA ++ K Sbjct: 1363 ERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTK 1422 Query: 229 DTMIEQLD-------------KTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQ 275 + + ++LD L + +++ AE + +E AE +++ Sbjct: 1423 NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKE 1482 Query: 276 ETVTRLEQSLSEAMEALNREQESARLQQRERETL--------------EEERQALTLRLE 321 L ++L EA+EA + + ++ + E E L E+ ++AL ++E Sbjct: 1483 TKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQME 1542 Query: 322 AEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQ 381 + + L++E A +L ++ L+ E + Q +Q + + Q E + Sbjct: 1543 EMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602 Query: 382 AQLEREKEKSQREAQA---------------------AWETQHQLALVQSEVRRLEGELD 420 +LE E+++ A A E QL +Q++++ + EL+ Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELE 1662 Query: 421 TARRERD---ALQLEMSLVQARYESQRIQLESELAVQLEQR-----VTERLAQAQESSLR 472 AR RD A E E+ +QL+ +LA R E LA+ SSL Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLS 1722 Query: 473 QAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARV 532 +L++ R+ L+ Q ++EL + + M++R + Q AE LA E++ Sbjct: 1723 GRNALQDEKRR-LEARIAQLEEELEEEQGNMEA-MSDRVRKATQQAEQLSNELATERSTA 1780 Query: 533 CELQSGNQQLEEQRVELVERLQAM 556 + +S QQLE Q EL +L M Sbjct: 1781 QKNESARQQLERQNKELRSKLHEM 1804 Score = 72.0 bits (175), Expect = 2e-12 Identities = 99/417 (23%), Positives = 183/417 (43%), Gaps = 60/417 (14%) Query: 197 RKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVE-----GWNRHEA 251 R E + +T+ L L + L A+ A + + + L + +V G N HE Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHEL 1530 Query: 252 ERTE------------VLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESA 299 E+++ L L++E QA E + + + + L+ ++A + + E Sbjct: 1531 EKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEK 1590 Query: 300 RLQQR----ERET-LEEERQALTLRLEAEQQRCCVLQE---ERDAARAG----------- 340 R Q + E ET LE+ER+ L A+++ L++ + D+A G Sbjct: 1591 RRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKL 1650 Query: 341 --QLSE-HRELETLRAALEEERQTWAQQEHQLKE---HYQALQEESQAQLEREKEKSQRE 394 Q+ + RELE RA+ +E T + E + K LQE+ A K+ + Sbjct: 1651 QAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEK 1710 Query: 395 AQAAWETQHQLA---LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451 + A E L+ +Q E RRLE + E + Q M + S R++ ++ Sbjct: 1711 EELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAM-----SDRVRKATQQ 1765 Query: 452 AVQLEQRV-TER-LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAE 509 A QL + TER AQ ES+ +Q + R +L ++ G + + S +A + ++A+ Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ 1825 Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQ 566 EE+ +Q A + +QA L+ +++L+E ++ VE + M + + ++A + Sbjct: 1826 LEEQVEQEARE-------KQAATKSLKQKDKKLKEILLQ-VEDERKMAEQYKEQAEK 1874 Score = 70.1 bits (170), Expect = 9e-12 Identities = 82/391 (20%), Positives = 163/391 (41%), Gaps = 61/391 (15%) Query: 77 RSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTML---QTSRDTAYRDPLIPGAGSERREE 133 ++L E++L+ +D E R QLQ L +T + + + A ++ E Sbjct: 1570 QALKGQFERDLQARDEQN-----EEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624 Query: 134 DSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSE 193 D D + L S+ + EE + L+ + + R + D Sbjct: 1625 DLKDLE-------------LQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671 Query: 194 HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAER 253 K E+ +SL+ +++LQ+ LA A A ++ D E+L + LA + G N + E+ Sbjct: 1672 FATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEK 1731 Query: 254 TEV---LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLE 310 + + L+EE + + + V + Q + L E+ +A+ + R+ LE Sbjct: 1732 RRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLE 1791 Query: 311 EERQALTLRLE---------------AEQQRCCVLQE-------ERDAARAGQLSEHREL 348 + + L +L A + + L+E E+ AA + ++L Sbjct: 1792 RQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKL 1851 Query: 349 ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALV 408 + + +E+ER+ A+Q + E A ++ + QLE +E+SQR + Sbjct: 1852 KEILLQVEDERKM-AEQYKEQAEKGNARVKQLKRQLEEAEEESQR--------------I 1896 Query: 409 QSEVRRLEGELDTARRERDALQLEMSLVQAR 439 + R+L+ ELD A +A+ E++ ++++ Sbjct: 1897 NANRRKLQRELDEATESNEAMGREVNALKSK 1927 Score = 69.7 bits (169), Expect = 1e-11 Identities = 99/472 (20%), Positives = 197/472 (41%), Gaps = 62/472 (13%) Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 + Q LD E ++ + + I+ L+ + +LQ+ L AA K + L + L Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL-- 1148 Query: 242 VVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301 EA +TE+ L EL R+K+++ VT L+++L E E + E + + Sbjct: 1149 --------EALKTELEDTLDSTATQQEL-RAKREQEVTVLKKALDE--ETRSHEAQVQEM 1197 Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT 361 +Q+ + +EE + L E+ A+A + LE A L E + Sbjct: 1198 RQKHAQAVEELTEQL---------------EQFKRAKANLDKNKQTLEKENADLAGELRV 1242 Query: 362 WAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDT 421 Q + +++ + L+ AQ++ + K +A E ++ +Q+EV + G L+ Sbjct: 1243 LGQAKQEVEHKKKKLE----AQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNE 1298 Query: 422 ARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHH 481 A + L +++ + ++ + + L+ E +L V+ +L Q +E Sbjct: 1299 AEGKAIKLAKDVASLSSQLQDTQELLQEETRQKL--NVSTKLRQLEE------------E 1344 Query: 482 RKQLQDLSGQH---QQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSG 538 R LQD + +Q L ++ +++++ +++ Q A E ++ E+++ Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENL 1404 Query: 539 NQQLEEQRV--ELVERLQAMLQAHWDE-------ANQLLSTTLPPPNP----PAPPAGPS 585 QQ EE+ + +E+ + LQ D+ QL+S A S Sbjct: 1405 TQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNIS 1464 Query: 586 SPGPQEPEKEERRVWTMPPMAVALKPVLQQSREARDELPGAPPVLCSSSSDL 637 S E ++ E A++L L+++ EA++EL +L + DL Sbjct: 1465 SKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDL 1516 Score = 68.6 bits (166), Expect = 3e-11 Identities = 83/388 (21%), Positives = 166/388 (42%), Gaps = 54/388 (13%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRH 249 L+ E R + + + + ++L+L++QL AA +K QL+K A Sbjct: 931 LEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKL-----QLEKVTA--------- 976 Query: 250 EAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETL 309 EA+ ++ L++E + +K + LE+ +S+ L E+E A+ + + Sbjct: 977 EAK----IKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKH 1032 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQL 369 E L +RL+ E++ L++ + H ++ L+A + E + A++E Sbjct: 1033 ESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE--- 1089 Query: 370 KEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDAL 429 EE QA L R ++ ++ A ++ ++ + L+ +LD+ R R+ Sbjct: 1090 --------EELQAALARLDDEIAQKNNAL----KKIRELEGHISDLQEDLDSERAARNKA 1137 Query: 430 QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLR-EHHRKQLQDL 488 + + + E+ + +LE L Q+ + + + L++A H Q+Q++ Sbjct: 1138 EKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEM 1197 Query: 489 SGQHQQ---ELASQLAQFKVEMAEREERQQ-----------------QVAEDYELRLARE 528 +H Q EL QL QFK A ++ +Q Q ++ E + + Sbjct: 1198 RQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKL 1257 Query: 529 QARVCELQSGNQQLEEQRVELVERLQAM 556 +A+V ELQS E R EL +++ + Sbjct: 1258 EAQVQELQSKCSDGERARAELNDKVHKL 1285 Score = 67.0 bits (162), Expect = 7e-11 Identities = 68/312 (21%), Positives = 136/312 (43%), Gaps = 35/312 (11%) Query: 272 SKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQ 331 ++Q+E + E L + E + + + +++ L EE+ L +L+AE + + Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907 Query: 332 EERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKS 391 E R A + L + A LEEE Q + + K + +Q L+ E++ Sbjct: 908 EMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERK-------KMAQQMLDLEEQLE 960 Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL--ES 449 + EA A + Q + ++++++LE E+ + + L E L++ R L E Sbjct: 961 EEEA-ARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEE 1019 Query: 450 ELAVQLEQRVTERLAQAQESSLR------QAASLREHHRKQLQDLSGQHQQ--ELASQLA 501 E A L + + + E +R L + RK D S H+Q +L +Q+A Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIA 1079 Query: 502 QFKVEMAEREERQQQVAEDYELRLARE----------QARVCELQ-------SGNQQLEE 544 + K+++A++EE Q + +A++ + + +LQ + + E+ Sbjct: 1080 ELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK 1139 Query: 545 QRVELVERLQAM 556 Q+ +L E L+A+ Sbjct: 1140 QKRDLGEELEAL 1151 Score = 65.1 bits (157), Expect = 3e-10 Identities = 75/306 (24%), Positives = 138/306 (45%), Gaps = 48/306 (15%) Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329 T+ K VTR E+ + + L + +E + + E + LE++ LT Sbjct: 839 TKVKPLLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLT------------ 886 Query: 330 LQEERDAARAGQLSEHRELET-LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388 EE++ L E + ET L A EE R A ++ +L+E + E +A+LE E+ Sbjct: 887 --EEKNL-----LQEQLQAETELYAEAEEMRVRLAAKKQELEE----ILHEMEARLEEEE 935 Query: 389 EKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLE 448 ++ Q + Q + + ++ LE +L+ R LQLE +A+ + +LE Sbjct: 936 DRGQ-------QLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIK----KLE 984 Query: 449 SELAVQLEQR----VTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFK 504 E+ V +Q +L + + S L + E K L L +H+ S +++ + Sbjct: 985 DEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNKHE----SMISELE 1040 Query: 505 VEMAEREERQQQVAEDYELRLAREQA----RVCELQSGNQQLEEQRVELVERLQAMLQAH 560 V + ++EE+ +Q E + +L + + ++ +LQ+ +L+ Q + E LQA L Sbjct: 1041 VRL-KKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099 Query: 561 WDEANQ 566 DE Q Sbjct: 1100 DDEIAQ 1105 Score = 64.7 bits (156), Expect = 4e-10 Identities = 105/483 (21%), Positives = 201/483 (41%), Gaps = 75/483 (15%) Query: 36 SQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRS---LSVGLEKNLKKKDG 92 S YA R +AEA + L E L+ +EL R+ L +E + KD Sbjct: 1464 SSKYADERDRAEAEAREKETKALSLARALEEALEA-KEELERTNKMLKAEMEDLVSSKDD 1522 Query: 93 -SKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151 K++ E+E + L+T ++ + E +E D+ L Sbjct: 1523 VGKNVHELEKSKRALETQMEEMKTQL----------EELEDELQATEDAKLRL------- 1565 Query: 152 DLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRKHCERHIQSLQTRV 211 + QAL+ F R D Q RD + E +R+ +R + +T + Sbjct: 1566 ----EVNMQALKGQFER-------------DLQA-RDEQNEE--KRRQLQRQLHEYETEL 1605 Query: 212 LELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT-----EVLRGLQEEHQA 266 + ++Q A+A AA +K + ++ L+ ++G R EA + ++ Q E + Sbjct: 1606 EDERKQRALAAAAKKKLEGDLKDLELQADSAIKG--REEAIKQLRKLQAQMKDFQRELED 1663 Query: 267 AELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQR 326 A +R + T E+ L + QE +R R+ + E++ L L + Sbjct: 1664 ARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSG 1723 Query: 327 CCVLQEE--RDAARAGQLSEHRE-----LETLRAALEEERQTWAQQEHQLKEHYQALQ-- 377 LQ+E R AR QL E E +E + + + Q Q ++L Q Sbjct: 1724 RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKN 1783 Query: 378 EESQAQLEREKEKSQ---REAQAAWETQHQ--LALVQSEVRRLEGELDTARRERDALQLE 432 E ++ QLER+ ++ + E + A +++ + +A +++++ +LE +++ RE+ A Sbjct: 1784 ESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKS 1843 Query: 433 MSLVQARYESQRIQLESE--LAVQLEQ----------RVTERLAQAQESSLRQAASLREH 480 + + + +Q+E E +A Q ++ ++ +L +A+E S R A+ R+ Sbjct: 1844 LKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKL 1903 Query: 481 HRK 483 R+ Sbjct: 1904 QRE 1906 Score = 60.1 bits (144), Expect = 9e-09 Identities = 81/367 (22%), Positives = 150/367 (40%), Gaps = 64/367 (17%) Query: 255 EVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQR---------- 304 E ++ ++E Q + + K + + LEQ S+ E N QE + + Sbjct: 852 EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRV 911 Query: 305 ----ERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAA------ 354 +++ LEE + RLE E+ R LQ ER L +LE AA Sbjct: 912 RLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQL 971 Query: 355 -----------LEEERQTWAQQEHQLKEHYQALQE---ESQAQLEREKEKSQREAQAAWE 400 LE+E Q ++L + + L+E + L E+EK++ + + Sbjct: 972 EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKL--K 1029 Query: 401 TQHQLALVQSEVR-----RLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQL 455 +H+ + + EVR + EL+ +R+ + + A ++Q +L+ +LA + Sbjct: 1030 NKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKE 1089 Query: 456 EQ------RVTERLAQAQESSLRQAASLREHHRKQLQDLSGQ---------HQQELASQL 500 E+ R+ + +AQ + ++L++ L H +DL + +++L +L Sbjct: 1090 EELQAALARLDDEIAQ-KNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEEL 1148 Query: 501 AQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAH 560 K E+ E+ A ELR REQ E+ + L+E+ ++Q M Q H Sbjct: 1149 EALKTEL---EDTLDSTATQQELRAKREQ----EVTVLKKALDEETRSHEAQVQEMRQKH 1201 Query: 561 WDEANQL 567 +L Sbjct: 1202 AQAVEEL 1208 Score = 43.9 bits (102), Expect = 7e-04 Identities = 53/250 (21%), Positives = 103/250 (41%), Gaps = 37/250 (14%) Query: 344 EHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQH 403 + E++ L++ ++ + E++LKE E+ +QL EK Q + QA E Sbjct: 850 QEEEMQAKEDELQKTKERQQKAENELKE-----LEQKHSQLTEEKNLLQEQLQAETE--- 901 Query: 404 QLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERL 463 + +E + L ++E + + EM E + QL++E +Q + Sbjct: 902 ----LYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEE 957 Query: 464 AQAQESSLRQAASLR----EHHRKQLQD----------LSGQHQQELASQLAQFKVEMAE 509 +E + RQ L E K+L+D + ++ L +++ +AE Sbjct: 958 QLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAE 1017 Query: 510 REE----------RQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQA 559 EE + + + + E+RL +E+ EL+ ++LE + E++ A LQA Sbjct: 1018 EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI-ADLQA 1076 Query: 560 HWDEANQLLS 569 E L+ Sbjct: 1077 QIAELKMQLA 1086 >gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 828 Score = 82.8 bits (203), Expect = 1e-15 Identities = 93/404 (23%), Positives = 184/404 (45%), Gaps = 38/404 (9%) Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGW 246 RDAL E R + L+ + ELQ++L +A + + +++L + L R Sbjct: 168 RDALSLELYRNTITN---EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLL 224 Query: 247 NRHEAERTEVLRGLQEEH-QAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRE 305 + + + QEE + E KQ+E + R E+ L E E REQE +++++E Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLRE-QEGKMREQEE-KMRRQE 282 Query: 306 RETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQ- 364 + E+E++ E +Q+ QEE+ + ++ E E E+E + W Q Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEE-----KMREQEEKMWRQE 337 Query: 365 -----QEHQLKEHYQALQEESQAQLE-----REKEKSQREAQAAWETQHQL---ALVQSE 411 QE Q++E Q ++++ + E REKE+ RE + WE + ++ ++ Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397 Query: 412 VRRLEGELDTARRERDALQL--EMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQES 469 +++ E +T R + + +Q E Q E Q+ +L + EQ E++ + +E Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQ---EKMQEQEEK 454 Query: 470 SLRQAASLREHHRKQLQDLSGQHQQELASQLAQF---KVEMAEREER---QQQVAEDYEL 523 Q +R+ Q+ Q+++ Q Q + +M ++E++ Q++ + + Sbjct: 455 IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDE 514 Query: 524 RLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567 RL ++ R+ E + QQ E+ R E ++ Q + WD+ ++ Sbjct: 515 RLREKEERMREQKKMWQQEEKMREE--KKTQEQEKKTWDQEEKM 556 Score = 77.4 bits (189), Expect = 6e-14 Identities = 77/406 (18%), Positives = 182/406 (44%), Gaps = 45/406 (11%) Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADR---KKDTMIEQLDKTLARV 242 +R+ + + K + L+ + EL++Q + ++ +++ M EQ +K + Sbjct: 271 MREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQE 330 Query: 243 VEGWNRHEA--ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNRE---QE 297 + W + E E+ + +R +++ + E +Q E + E+ + E + +E QE Sbjct: 331 EKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390 Query: 298 SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALE 356 R+++RE++ EEE + ++Q + ++E + +L E +E L E Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 450 Query: 357 EERQTWAQQE----------HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLA 406 +E + W Q+E + K Q E + Q+ ++EK + + Q W+ + ++ Sbjct: 451 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM- 509 Query: 407 LVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQA 466 E D RE++ + R + + Q E ++ + + + E+ Sbjct: 510 ----------WEQDERLREKEE--------RMREQKKMWQQEEKMREEKKTQEQEKKTWD 551 Query: 467 QESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREER---QQQVAEDYEL 523 QE +R+ +RE +K ++ +QE ++ + + +M E+EE+ Q++ ++ E Sbjct: 552 QEEKMREEERMREREKKMREEEEMMREQE--EKMQEQEEKMREQEEKMWEQEEKMQEQEE 609 Query: 524 RLAREQARVCELQSGN--QQLEEQRVELVERLQAMLQAHWDEANQL 567 ++ ++ ++ E + + Q+ EE E E++Q + W++ ++ Sbjct: 610 KMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKM 655 Score = 72.0 bits (175), Expect = 2e-12 Identities = 65/386 (16%), Positives = 170/386 (44%), Gaps = 30/386 (7%) Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEA-ERTEVLRG 259 E + + ++ E +Q++ ++D + + ++ + + W + E + E +R Sbjct: 337 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRE 396 Query: 260 LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLR 319 +++ + E T +Q+E + + E+++ E E +E + RL +++ + E+E+ Sbjct: 397 REKKMREEEETMREQEEKMQKQEENMWEQEE---KEWQQQRLPEQKEKLWEQEKMQ---- 449 Query: 320 LEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379 EQ+ QEE+ + + +++ E+E Q W +QE ++++ Q + ++ Sbjct: 450 ---EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMW-EQEEKMRDQEQKMWDQ 505 Query: 380 SQAQLE-----REKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMS 434 + E REKE+ RE + W+ + ++ + + + D + R+ ++ Sbjct: 506 EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565 Query: 435 LVQARYESQRIQLESELAVQLEQRVTE---RLAQAQESSLRQAASLREHHRKQLQDLSGQ 491 + R E + ++ + E + E+++ E ++ + +E Q + E K + Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625 Query: 492 HQQELASQLAQFKVEMAERE----------ERQQQVAEDYELRLAREQARVCELQSGNQQ 541 QE + + + +M E+E Q++ + E ++ ++ ++ E + Q Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQG 685 Query: 542 LEEQRVELVERLQAMLQAHWDEANQL 567 EE+ E E+++ + W + ++ Sbjct: 686 QEEKMREQEEKMRGQEEKMWGQEEKM 711 Score = 61.6 bits (148), Expect = 3e-09 Identities = 68/311 (21%), Positives = 135/311 (43%), Gaps = 46/311 (14%) Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA--ERTEVLRGLQEEHQAAELTRSKQQETVTRLEQS 284 ++D M EQ +K + + W++ E E+ E LR ++E + E + QQE R E+ Sbjct: 484 QEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLR--EKEERMREQKKMWQQEEKMREEKK 541 Query: 285 LSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSE 344 E + ++E R ++R RE ++ R+ + E E++ +QE+ + R Sbjct: 542 TQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK----MQEQEEKMR------ 591 Query: 345 HRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQ 404 E E+E + Q+E ++ + ++E E++K Q + + WE + + Sbjct: 592 ----EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE-------EEDKMQEQEEMMWEQEEK 640 Query: 405 LALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLA 464 + Q + ++ + + R + + ++ + +Q + E R Q E Sbjct: 641 M---QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ--------------EEKM 683 Query: 465 QAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQF-KVEMAEREERQQQVAEDYEL 523 Q QE +R+ E R Q + + GQ ++ + + + EM E+EER + E + Sbjct: 684 QGQEEKMREQ---EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQE 740 Query: 524 RLAREQARVCE 534 RL + R E Sbjct: 741 RLPEHEERCSE 751 Score = 61.2 bits (147), Expect = 4e-09 Identities = 67/393 (17%), Positives = 179/393 (45%), Gaps = 26/393 (6%) Query: 188 DALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARV-VEGW 246 + L + + + E+ ++ + R+ E ++L R+++ M EQ +K + Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRER 397 Query: 247 NRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER 306 + E E +R +E+ Q E +Q+E + +Q L E E L +++ Q + Sbjct: 398 EKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ-QQRLPEQKEKLWEQEK----MQEQE 452 Query: 307 ETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHREL--ETLRAALEEERQTWAQ 364 E + E+ + + + E Q + ++E+ + Q+ E E + + ++E + W Q Sbjct: 453 EKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ 512 Query: 365 QEHQLKEHYQALQEES----QAQLEREKEKSQREAQAAWETQHQLA---LVQSEVRRLEG 417 E +L+E + ++E+ Q + RE++K+Q + + W+ + ++ ++ +++ Sbjct: 513 DE-RLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMRE 571 Query: 418 ELDTARRERDALQLEMSLVQARYES-----QRIQLESELAVQLEQRVTERLAQAQESSLR 472 E + R + + +Q + ++ + E +++Q + E + E+++ E Q +E ++ Sbjct: 572 EEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE---QEEEDKMQ 628 Query: 473 QAASLREHHRKQLQDLSGQ--HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQA 530 + + +++Q+ + Q+E + + E E+ + Q++ + E ++ ++ Sbjct: 629 EQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE 688 Query: 531 RVCELQSGNQQLEEQRVELVERLQAMLQAHWDE 563 ++ E + + EE+ E++ + W + Sbjct: 689 KMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 721 Score = 56.6 bits (135), Expect = 1e-07 Identities = 84/398 (21%), Positives = 170/398 (42%), Gaps = 44/398 (11%) Query: 187 RDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRK-KDTMIEQLDKTLARVVEG 245 ++AL E + H R + +T EL+ L + A RK +D + + R+ Sbjct: 80 QEALRREIEAQDHTIRILTCQKT---ELETALYYSQDAARKFEDGNLGESKDLAGRLHHS 136 Query: 246 WNRHEAERTEVLRGLQEEHQAA-----ELTRSKQQETVTRLEQSLS-EAMEALNRE-QES 298 W+ E L + H+ A ELT+ + ++ +++ E ++ N E QE Sbjct: 137 WH-FAGELQRALSAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEK 195 Query: 299 ARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEE 358 RL + E+ ++ + L +LE + + + Q + + + + EL + ++ Sbjct: 196 LRLAESEKSEIQLNVKELKRKLE--RAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQ 253 Query: 359 RQTWAQQEHQLKEHYQALQEES-----QAQLEREKEKSQREAQAAWETQHQL-----ALV 408 + +QE +L+E ++E+ Q + RE+EK RE + Q +L + Sbjct: 254 EEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQ 313 Query: 409 QSEVRRLEGELDTARRERDALQLEMSL----VQARYESQRIQLESELAVQLEQRVTERLA 464 + E + E E +E + E L Q R + Q+++ + E + ++R+ E+ Sbjct: 314 EQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEE 373 Query: 465 Q--------AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQ 516 + QE +++ +RE +K ++ +QE Q + + E +E QQQ Sbjct: 374 RMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQ 433 Query: 517 VAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554 RL ++ ++ E Q Q+ EE+ E E+++ Sbjct: 434 -------RLPEQKEKLWE-QEKMQEQEEKIWEQEEKIR 463 >gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 668 Score = 82.4 bits (202), Expect = 2e-15 Identities = 112/553 (20%), Positives = 241/553 (43%), Gaps = 51/553 (9%) Query: 32 SEVTSQLYASLRLSRQAEATARAQLYLPSTSPPHEGLDGFAQELSRSLSVGLEKNLKKKD 91 +E+ LY S +Q E AR + S H+ FA EL ++LS + KK Sbjct: 140 TELQMALYYSQHAVKQLEGEARDLI-----SRLHDSWK-FAGELEQALSAVATQ---KKK 190 Query: 92 GSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERREEDSFDSDSTATLLNTRPLQ 151 ++I E+ R L L+ R+T + L + + +S+ + LN + L+ Sbjct: 191 ADRYIEELTKERDALS--LELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELK 248 Query: 152 D-------LSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDSEHTRRK-HCERH 203 L P QA + + + L + L+ + + E Sbjct: 249 RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEK 308 Query: 204 IQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEG-WNRHEAERT--EVLRGL 260 IQ + ++ E ++++ R+++ I + ++ + R E W + E R E++ Sbjct: 309 IQEWEEKIQEQEEKI-------REQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK 361 Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320 +E+ + E +++E + LE+ + E + REQE R Q+ E+ +E+RQ ++ Sbjct: 362 EEKMRRLEEMMWEKEEKIRELEEKMHEQEKI--REQEEKR-QEEEKIREQEKRQEQEAKM 418 Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRELETL--RAALEEERQTWAQQEHQLKEHYQALQE 378 ++++ ++E+ + R + R+ E + + + EE + Q+E +E QE Sbjct: 419 WRQEEK---IREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQE 475 Query: 379 ESQAQLER--EKEKSQREAQAAWETQHQLALVQSEVRRLEGEL-----------DTARRE 425 E Q E+ E+EK +++ + W + ++ + ++R E ++ + R + Sbjct: 476 EIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQ 535 Query: 426 RDALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHRK-Q 484 + ++ + ++Q + E Q E + +R E++ + +E Q +RE K Sbjct: 536 EEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIW 595 Query: 485 LQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEE 544 Q+ + Q+E+ + + E E+ Q++ ++ E ++ R++ ++ E + +Q EE Sbjct: 596 EQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEE 655 Query: 545 QRVELVERLQAML 557 + E E L+A + Sbjct: 656 KMQEHQEHLEAAI 668 Score = 74.3 bits (181), Expect = 5e-13 Identities = 75/405 (18%), Positives = 179/405 (44%), Gaps = 31/405 (7%) Query: 186 LRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVV-- 243 L++ L + + + +++ L+ R LE + L + D + ++L A++ Sbjct: 226 LQEKLQLVESEKSEIQLNVKELK-RKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ 284 Query: 244 ----EGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQE-- 297 E WNR ++ E + +E+ Q E +Q+E + E+ + E E + R++E Sbjct: 285 VEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMM 344 Query: 298 -SARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALE 356 + R +E + E++ RLE ++ E+ + R + H E E +R E Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEE------MMWEKEEKIRELEEKMH-EQEKIREQEE 397 Query: 357 EERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQ---HQLALVQSEVR 413 + ++ +E + ++ +A + ++ ++EK + + + W + H+ ++ E + Sbjct: 398 KRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEK 457 Query: 414 RLEGELDTARRERDALQLEMSLVQAR-YESQRIQLESELAVQLEQRV----------TER 462 R E E + E+ Q E+ + + +E ++I+ + E + E+++ E+ Sbjct: 458 RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEK 517 Query: 463 LAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYE 522 + + +E Q +RE K + +QE + K++ E+ RQ++ + E Sbjct: 518 MWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQE 577 Query: 523 LRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQL 567 ++ ++ ++ E + + EE+ E E +Q + W++ ++ Sbjct: 578 EKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKM 622 >gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like [Homo sapiens] Length = 899 Score = 82.4 bits (202), Expect = 2e-15 Identities = 96/398 (24%), Positives = 176/398 (44%), Gaps = 45/398 (11%) Query: 213 ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLR---GLQEEHQAAEL 269 ELQ+ L+ +K D IE+L K + R+ E+ + LQE+ AE Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLAES 239 Query: 270 TRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCV 329 +S+ Q V L++ L A L + Q + ++ R+ E Q +R + E+ Sbjct: 240 EKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKM---W 296 Query: 330 LQEERDAARAGQLSEHRE-LETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREK 388 QEER + G++ E E + L E+ + +QE +L+E + ++E Q Q + EK Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356 Query: 389 ------------EKSQREAQAAWETQHQLALVQSEVRRLE---GELDTARRERDALQLEM 433 EK R+ + WE + Q+ + ++R E E D RE++ E Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQ 416 Query: 434 SLVQARYESQRIQ----------LESELAVQLEQRVTER--LAQAQESSLRQAASLREHH 481 + + E R + + E +Q E+R+ ER + +E ++R+ E Sbjct: 417 EKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQ---EEKM 473 Query: 482 RKQLQDLSGQHQQELASQ-LAQFKVEMAEREERQQQVAEDYE----LRLARE---QARVC 533 +KQ +++ Q ++E Q L + K ++ E+E+ Q+Q + +E +R E Q + Sbjct: 474 QKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKM 533 Query: 534 ELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLSTT 571 Q ++ E+Q E E+++ Q WD+ ++ T Sbjct: 534 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKT 571 Score = 76.6 bits (187), Expect = 9e-14 Identities = 77/422 (18%), Positives = 192/422 (45%), Gaps = 28/422 (6%) Query: 201 ERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGL 260 E + + ++ E +Q++ ++D + + ++ + + W + E R E Sbjct: 375 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434 Query: 261 QEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRL 320 QE+ + + +++E + E+ + E E + REQE +Q E +EE++ RL Sbjct: 435 QEKKTRDQEEKMQEEERIREREKKMREEEETM-REQEEKMQKQEENMWEQEEKEWQQQRL 493 Query: 321 EAEQQRCCVLQEERDAARAGQLSEHRE-LETLRAALEEERQTWAQ-----QEHQLKEHYQ 374 ++++ + ++E+ + ++ E E + +E++ W Q QE Q+ E + Sbjct: 494 PEQKEK--LWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551 Query: 375 ALQEESQA---QLEREKEKSQREAQAAWETQHQL---ALVQSEVRRLEGELDTARRERDA 428 ++++ Q Q ER ++K+Q + + W+ + ++ ++ +++ E + R + + Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611 Query: 429 LQLEMSLVQARYE-----SQRIQLESELAVQLEQRVTERLAQ--AQESSLRQAASLREHH 481 +Q + +Q + E +++Q + E + E+++ E+ + Q+ Q L EH Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671 Query: 482 RKQLQDLSGQHQQELASQLAQFKVEMAEREER---QQQVAEDYELRLAREQARVCELQSG 538 + Q Q+ Q Q+E + + + + E+E++ Q+++ E+ +R ++ R E + Sbjct: 672 KMQEQE-KMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR--EEEEM 728 Query: 539 NQQLEEQRVELVERLQAMLQAHWDEANQLLSTTLPPPNPPAPPAGPSSPGPQEPEKEERR 598 ++ EE+ E E++Q + W++ ++ P E +E+ + Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788 Query: 599 VW 600 +W Sbjct: 789 IW 790 Score = 66.6 bits (161), Expect = 1e-10 Identities = 72/345 (20%), Positives = 147/345 (42%), Gaps = 18/345 (5%) Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA----ERTEVLRGLQEEHQAAELTRSKQQETVTRLE 282 ++D M EQ +K + + W++ E + + + +E + E R +++E R E Sbjct: 542 QEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601 Query: 283 QSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEE------RDA 336 + + E +EQE +Q E+ +EE+ EQ+ QEE R Sbjct: 602 EEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661 Query: 337 ARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLE-----REKEKS 391 + +L EH +++ E+E + W Q++ + K Q + Q ++ RE+EK Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKK 721 Query: 392 QREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESEL 451 RE + Q + Q E + + E + E+ Q E Q R Q+ +L Sbjct: 722 MREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 781 Query: 452 AVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVE--MAE 509 +Q ++++ E+ + ++ + E R Q + + GQ ++ + + E M Sbjct: 782 KMQEQEKIWEQEEKMRDQEEKMRGQ-EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG 840 Query: 510 REERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554 +EE+ E E ++ ++ ++ E + + EE+ E E+++ Sbjct: 841 QEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885 Score = 45.4 bits (106), Expect = 2e-04 Identities = 51/203 (25%), Positives = 86/203 (42%), Gaps = 35/203 (17%) Query: 398 AWETQHQLALVQSEVRRLEGELDTARRERDALQLEM-------------------SLVQA 438 A E Q L+ V + ++ + ++ +ERDAL LE+ L A Sbjct: 178 AGELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAELQEKLPLA 237 Query: 439 RYESQRIQLESELAVQLEQRVTERLAQAQESSL-----RQAASLREHHRKQLQDLSGQHQ 493 E IQL + + +R L Q Q ++L RQ LRE +K + + Sbjct: 238 ESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWR 297 Query: 494 QELASQLAQFKVEMAEREE---RQQQVAEDYELRL------AREQARVCELQSGNQQLEE 544 QE +L + + +M E+EE RQ++ + E L REQ + E + Q+ EE Sbjct: 298 QE--ERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEE 355 Query: 545 QRVELVERLQAMLQAHWDEANQL 567 + E E+++ + W + +L Sbjct: 356 KMWEQEEKMREQEEKMWRQEERL 378 Score = 33.1 bits (74), Expect = 1.2 Identities = 29/159 (18%), Positives = 73/159 (45%), Gaps = 7/159 (4%) Query: 227 KKDTMIEQLDKTLARVVEGWNRHEA------ERTEVLRGLQEEHQAAELTRSKQQETVTR 280 +++ M EQ +K + E W + E + E R +++ + E + ++QE + Sbjct: 732 QEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWE 791 Query: 281 LEQSLSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAG 340 E+ + + E + ++E R Q+ + EE+ ++ ++++ QEE+ + Sbjct: 792 QEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG-QEEKMWGQEE 850 Query: 341 QLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEE 379 ++ E + + + +EE+ +++ + +E QEE Sbjct: 851 KMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 82.4 bits (202), Expect = 2e-15 Identities = 90/449 (20%), Positives = 198/449 (44%), Gaps = 51/449 (11%) Query: 148 RPLQDLSPSSSAQALEELFPRYTSLRPGPPL-----NPPDFQGLRDALDSEHTRRKHCER 202 +PL L P + EE G P+ + + L+ + + K C+ Sbjct: 246 KPLPQLEPQAEVFTKEE-----NPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKE 300 Query: 203 HIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQE 262 IQS + + L + K+ + EQLD+ L + + + H AE+T+++ L++ Sbjct: 301 TIQSHKEQCTLLTSE----------KEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350 Query: 263 EHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARLQQRER-------ETLEEERQA 315 E + + ++ + E +E +E+E A+L+ R + E E++ ++ Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEM--KEEEIAQLRSRIKQMTTQGEELREQKEKS 408 Query: 316 LTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEH--- 372 E ++ Q+ +A R + +++T+ EEER + Q+ ++K+ Sbjct: 409 ERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVD 468 Query: 373 ------------YQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELD 420 Q L E+ A+ E+E K + + ++ Q ++AL +S+ L+ + Sbjct: 469 VMKKSSEEQIAKLQKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQE 528 Query: 421 TARRER---DALQLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASL 477 ++E + L+L+ + E++ L+ E A R+ E L + E SL++ + Sbjct: 529 KEQQESLALEELELQKKAILTESENKLRDLQQE-AETYRTRILE-LESSLEKSLQENKNQ 586 Query: 478 REHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQS 537 + L+ +H +E+ + + K E+ E + QQ +L++ ++Q + E++ Sbjct: 587 SKDLAVHLEAEKNKHNKEITVMVEKHKTEL-ESLKHQQDALWTEKLQVLKQQYQT-EMEK 644 Query: 538 GNQQLEEQRVELVERLQAMLQAHWDEANQ 566 ++ E+++ L++ + + QAH +E N+ Sbjct: 645 LREKCEQEKETLLKDKEIIFQAHIEEMNE 673 Score = 78.2 bits (191), Expect = 3e-14 Identities = 94/408 (23%), Positives = 194/408 (47%), Gaps = 79/408 (19%) Query: 190 LDSEHTRRKHCERHIQSLQTRVLELQ--------------QQLAVAVAADRKKD----TM 231 L + + ++ ++ +TR+LEL+ + LAV + A++ K T+ Sbjct: 548 LTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITV 607 Query: 232 IEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAA-ELTRSK---QQETVTRLEQSLSE 287 + + KT ++ ++ +A TE L+ L++++Q E R K ++ET+ + ++ + + Sbjct: 608 MVEKHKTELESLK--HQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ 665 Query: 288 A-MEALNREQ-ESARLQQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEH 345 A +E +N + E ++Q E E+L E + ++ VL+++ D + Sbjct: 666 AHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK------- 718 Query: 346 RELETLRAALEEERQTWAQQ-EHQLKEHYQALQEESQA------QLE---REKEKSQREA 395 + L A ++E++ QQ + +KEH ++Q +A QLE +E++K +E Sbjct: 719 ---QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEH 775 Query: 396 QAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQAR---YESQRIQLESELA 452 QA E ++++++R EGEL A + D Q S + YE Q QL+ +L Sbjct: 776 QAHVEN------LEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLL 829 Query: 453 VQLEQRV--TERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAER 510 +R+ T+++A+ E+ + + + H+ Q+QDL + Q + + +E Sbjct: 830 DLETERILLTKQVAEV-EAQKKDVCTELDAHKIQVQDL-----------MQQLEKQNSEM 877 Query: 511 EERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQ 558 E++ + + + YE +L + GN++ E+ + LVE+ +LQ Sbjct: 878 EQKVKSLTQVYESKL----------EDGNKEQEQTKQILVEKENMILQ 915 Score = 72.0 bits (175), Expect = 2e-12 Identities = 83/399 (20%), Positives = 180/399 (45%), Gaps = 50/399 (12%) Query: 191 DSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHE 250 + E T H E Q Q R+++L+ A A + +MI L + L + ++ Sbjct: 1758 EKEETVSSHFEMRCQ-YQERLIKLEH----AEAKQHEDQSMIGHLQEELEEKNKKYSLIV 1812 Query: 251 AERTEVLRG---------LQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301 A+ E G L+ + T +++ T LEQ + E L R++E R+ Sbjct: 1813 AQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRV 1872 Query: 302 QQRERETLEEERQALTLRLEAEQQRCCVLQEERDAARAGQL----------SEHRELETL 351 + E + E+ QAL +++ + +L+E + L ++H +LE Sbjct: 1873 EMEELTSKYEKLQALQ-QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFK 1931 Query: 352 RAALEEERQTWAQQEHQLKEHYQALQEESQAQLE-REKEKSQREAQAAWETQHQLALV-Q 409 A E E+Q ++ +L++ + L++E Q +LE +KE Q + + Q L L Sbjct: 1932 LAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHN 1991 Query: 410 SEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLE-QRVTERLAQAQE 468 S +++L E +T +++ +LEM++ + ++Q ++ E + Q E ++ +++A+ + Sbjct: 1992 STLKQLMREFNTQLAQKEQ-ELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDD 2050 Query: 469 SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAE--------- 519 R A K+ +++ ++E+ +++ + ++ E +++ QQ E Sbjct: 2051 DLKRTA--------KRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDN 2102 Query: 520 ----DYELRLAREQARVCELQSGNQQLEEQRVELVERLQ 554 + + +LA++ + + + Q+ EQ L +RL+ Sbjct: 2103 VTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141 Score = 70.1 bits (170), Expect = 9e-12 Identities = 120/592 (20%), Positives = 241/592 (40%), Gaps = 63/592 (10%) Query: 3 TSADSPSSPLGAEDLLSDSSEPPGLNQVSSEVTSQLYASLRLSRQAEATARAQLYLPSTS 62 T ++P S E ++ D + L + V Q R ++ L S Sbjct: 259 TKEENPESD--GEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEK 316 Query: 63 PP-HEGLDGFAQELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDP 121 E LD QEL + K+L + +K I ++ + ++ + Q Sbjct: 317 EALQEQLDERLQELEKI------KDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETK 370 Query: 122 LIPGAGSERREEDSFDSDSTATLLNTR--PLQDLSPSSSAQALEELFPRYTSLRPGPPLN 179 E +EE+ S + T+ L++ S A EEL ++ + Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430 Query: 180 PPDFQGLRDALDSE-HTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKT 238 + L+ +D + T K E SLQ + ++Q++ D K + EQ+ K Sbjct: 431 ----RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVV-----DVMKKSSEEQIAKL 481 Query: 239 LARVVEGWNRHEAERTEVLRGLQEEHQ-----AAELTRSKQQETVTRLEQSLSEAMEALN 293 + R E E T+ L+ + E Q A E ++S+ + EQ S A+E L Sbjct: 482 QKLHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELE 541 Query: 294 REQESARLQQRERETLEEERQALTLR---LEAEQQRCCVLQEERDAARAGQLSEHRELET 350 Q+ A L + E + + +++A T R LE E LQE ++ ++ L+ H E E Sbjct: 542 L-QKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSK--DLAVHLEAEK 598 Query: 351 -----------------LRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQR 393 L + ++ W ++ LK+ YQ E+ + + E+EKE + Sbjct: 599 NKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658 Query: 394 EAQAAWE---------TQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQR 444 + + ++ T +L + Q+E+ L EL + R L+ E+S+++ + + + Sbjct: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718 Query: 445 IQLESELAVQL--EQRVTERLAQAQESSLRQAASLREHHRKQLQDL---SGQHQQELASQ 499 +LE+++ Q Q+ + + + E S+++ + QL+ L +H +E + Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778 Query: 500 LAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQSGNQQLEEQRVELVE 551 + + ++ E QQ + ++ + + A + ++ +QL + + +L++ Sbjct: 779 VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLD 830 Score = 66.2 bits (160), Expect = 1e-10 Identities = 115/524 (21%), Positives = 218/524 (41%), Gaps = 73/524 (13%) Query: 73 QELSRSLSVGLEKNLKKKDGSKHIFEMESVRGQLQTMLQTSRDTAYRDPLIPGAGSERRE 132 Q+L +G EK+ + K+ + I +E+ ++ L+T +++E Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELET----------------KKKE 1607 Query: 133 EDSFDSDSTATLLNTRPLQDLSPSSSAQALEELFPRYTSLRPGPPLNPPDFQGLRDALDS 192 + + + + L+D S SA L EL + + Q L + Sbjct: 1608 LEHVNLSVKSKEEELKALEDRLESESAAKLAEL-----KRKAEQKIAAIKKQLLSQMEEK 1662 Query: 193 EHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAE 252 E +K E H+ L T++ E ++++ + + K ++ +TL +V ++ A Sbjct: 1663 EEQYKKGTESHLSELNTKLQEREREVHI---LEEKLKSVESSQSETL--IVPRSAKNVAA 1717 Query: 253 RTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR---EQESARLQQRERETL 309 TE QEE + + +E ++ L+++L+E + L R E+E E Sbjct: 1718 YTE-----QEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQ 1772 Query: 310 EEERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAAL---EEERQTWAQQE 366 +ER EA+Q D + G L E E + + +L + + + Sbjct: 1773 YQERLIKLEHAEAKQ--------HEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNN 1824 Query: 367 HQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRER 426 Q K++ + + ++ Q L+ EKE + + + + + Q EV R+E E T++ E+ Sbjct: 1825 IQAKQNLENVFDDVQKTLQ-EKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEK 1883 Query: 427 -DAL-QLEMSLVQARYESQRIQLESELAVQLEQRVTERLAQAQESSLRQAASLREHHR-- 482 AL Q++ + + +S+ + + ++ AQ + + A + RE + Sbjct: 1884 LQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943 Query: 483 -------KQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELR-------LARE 528 K L+ L +HQQEL ++ EREE+ +Q ED EL+ L RE Sbjct: 1944 KEIVRLQKDLRMLRKEHQQELEILKKEYD---QEREEKIKQEQEDLELKHNSTLKQLMRE 2000 Query: 529 QARVCELQSGNQQLEEQRVELVERLQ----AMLQAHWDEANQLL 568 +L Q+LE E + + Q +L++H +E NQLL Sbjct: 2001 FN--TQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLL 2042 Score = 61.6 bits (148), Expect = 3e-09 Identities = 74/376 (19%), Positives = 174/376 (46%), Gaps = 41/376 (10%) Query: 195 TRRKHCERHIQSLQTRVL-------ELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWN 247 +R HC+ ++ +L EL+ QL +++T+ + ++ E N Sbjct: 1248 SRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLT---EEQNTLNISFQQATHQLEEKEN 1304 Query: 248 RHEAERTEV------LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNREQESARL 301 + ++ + ++ LQ+E + S+++ +T+L++ LSE + A+ +E + Sbjct: 1305 QIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEELKE 1364 Query: 302 QQRERETLEEERQALTLRLE------AEQQRCCVLQEERDAARAGQLSEHRELETLRAAL 355 ++ E +L ++ L ++L+ ++ L+++ D + L + ++L L Sbjct: 1365 KKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTL 1424 Query: 356 EEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQHQLALVQSE-VRR 414 +E+ + +Q + ++++Q++ + + + +E Q E + + A + E + Sbjct: 1425 SKEKISALEQVDDWSNKFSEWKKKAQSRF-TQHQNTVKELQIQLELKSKEAYEKDEQINL 1483 Query: 415 LEGELDTARRERDALQLEMSLVQARYESQRIQLESEL------AVQLEQRVTERLAQAQE 468 L+ ELD + D L+ EM +++ E + LE+EL ++LE +T++ + + Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEIE- 1542 Query: 469 SSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRLARE 528 SL E + Q +H +EL +L F+ E+ E ++ + + AE+ L L + Sbjct: 1543 -------SLNEVLKNYNQQKDIEH-KELVQKLQHFQ-ELGEEKDNRVKEAEEKILTLENQ 1593 Query: 529 -QARVCELQSGNQQLE 543 + EL++ ++LE Sbjct: 1594 VYSMKAELETKKKELE 1609 Score = 57.8 bits (138), Expect = 5e-08 Identities = 64/313 (20%), Positives = 151/313 (48%), Gaps = 32/313 (10%) Query: 211 VLELQQQLAVAV-AADRKKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAEL 269 +L+ Q L+ V ++K + +EQ+D + E + ++ T+ ++E EL Sbjct: 1410 LLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLEL 1469 Query: 270 TRSKQQETVTRLEQS--LSEAMEALNREQESARLQQRERETLEEERQALTLRLEAEQQRC 327 K +E + EQ L E ++ N+ + + + + ++ E++++ L E + Q Sbjct: 1470 ---KSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES-NLETELKSQTA 1525 Query: 328 CVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLERE 387 +++ E + + E+E+L L+ Q Q++ + KE Q LQ + L E Sbjct: 1526 RIMELEDHITQ-----KTIEIESLNEVLKNYNQ---QKDIEHKELVQKLQHFQE--LGEE 1575 Query: 388 KEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQL 447 K+ +EA+ ++ ++++V ++ EL+T ++E + + L + + ++ +L Sbjct: 1576 KDNRVKEAE------EKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRL 1629 Query: 448 ESELAVQLEQRVTERLAQAQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEM 507 ESE A +LA+ + + ++ A++++ Q+++ Q+++ S L++ ++ Sbjct: 1630 ESESAA--------KLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKL 1681 Query: 508 AEREERQQQVAED 520 ER ER+ + E+ Sbjct: 1682 QER-EREVHILEE 1693 Score = 52.8 bits (125), Expect = 1e-06 Identities = 79/405 (19%), Positives = 174/405 (42%), Gaps = 62/405 (15%) Query: 182 DFQGLRDALDSEHTRRKHCERHIQSLQTRVLELQQQLAVAVAADRKKDTMIEQLDKTLAR 241 + + L L R E + L+ + +++Q+L + D +K+ +Q+D + Sbjct: 685 ELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKM--DEQKNHHQQQVDSIIKE 742 Query: 242 VVEGWNRHEAERTEVLRGLQ----------EEHQAAELTRSKQQETVTRLEQSLSEAMEA 291 R E + + L+ +EHQA + + R E L +A Sbjct: 743 HEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHV---ENLEADIKRSEGELQQASAK 799 Query: 292 LN---------------REQESARLQQRERETLEEERQALT---LRLEAEQQRCCVLQEE 333 L+ E++ A+LQQ+ + LE ER LT +EA+++ C E Sbjct: 800 LDVFQSYQSATHEQTKAYEEQLAQLQQKLLD-LETERILLTKQVAEVEAQKKDVCT---E 855 Query: 334 RDAARAGQLSEHRELETLRAALEEERQTWAQ-QEHQLKEHYQALQEESQAQLEREKEKSQ 392 DA + ++LE + +E++ ++ Q E +L++ + ++ Q +E+E Q Sbjct: 856 LDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQ 915 Query: 393 REAQAAWETQ---HQLALVQSEVRRLEGELDT----ARRERDALQLEMSLVQARYESQRI 445 E + +L+ + + L E +T ++ + ++ + +Q + + + Sbjct: 916 MREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975 Query: 446 QLESELAVQLEQRVTE-------------RLAQAQESSLRQAAS-LREHHRKQLQDLSGQ 491 E++L +LE E +AQA + + A S L + ++Q++ L+ Sbjct: 976 DQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEV 1035 Query: 492 HQQELASQLAQFKVEMAEREERQQQVAEDYELRLAREQARVCELQ 536 H++EL ++ ++ ++ ++ E Q++ +E++L ++ V EL+ Sbjct: 1036 HRRELNDVISIWEKKLNQQAEELQEI---HEIQLQEKEQEVAELK 1077 Score = 48.9 bits (115), Expect = 2e-05 Identities = 68/350 (19%), Positives = 149/350 (42%), Gaps = 22/350 (6%) Query: 227 KKDTMIEQLDKTLARVVEGWNRHEAERTEVLRGLQEEHQAAELTRSKQQETVTRLEQSLS 286 +K+ MI Q+ + + +E + + + + + L EE++ + K+ E V + + + Sbjct: 908 EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQ 967 Query: 287 EAMEALNREQESARLQQRERETLE---EERQALTLRLEAEQQRCCVLQEERDAARAGQLS 343 E ++ +QE+ ++ E LE +E+Q LE Q + + Q Sbjct: 968 ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKE 1027 Query: 344 EHREL-ETLRAALEEERQTWAQQEHQLKEHYQALQEESQAQLEREKEKSQREAQAAWETQ 402 + L E R L + W E +L + + LQE + QL+ EK Q A E + Sbjct: 1028 QIESLTEVHRRELNDVISIW---EKKLNQQAEELQEIHEIQLQ---EKEQEVA----ELK 1077 Query: 403 HQLALVQSEVRRLEGELDTARRERDALQLEMSLVQARYESQRIQLESELAVQLEQRVTER 462 ++ L E + E+ + E ++ +Q + + + + S L Q T+ Sbjct: 1078 QKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNS-----LAQDETKL 1132 Query: 463 LAQAQESSLRQAASLREHH--RKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAED 520 A ++ + SL+E+ ++QL +L +E ++++ ++ +E Q + Sbjct: 1133 KAHLEKLEVDLNKSLKENTFLQEQLVELK-MLAEEDKRKVSELTSKLKTTDEEFQSLKSS 1191 Query: 521 YELRLAREQARVCELQSGNQQLEEQRVELVERLQAMLQAHWDEANQLLST 570 +E + + E + +++L Q ++ +A+L+A +E + S+ Sbjct: 1192 HEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSS 1241 Score = 48.5 bits (114), Expect = 3e-05 Identities = 93/470 (19%), Positives = 181/470 (38%), Gaps = 105/470 (22%) Query: 198 KHCERHIQSL---QTRVLELQQQLAVAVAADRKKDTMIEQLDKTLARVVEGWNRHEAERT 254 K H+ SL +T++ ++L V + K++T +++ L + E R +E T Sbjct: 1116 KQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELT 1175 Query: 255 EVLRGLQEEHQAAELTRSKQQETVT-------RLEQSLSEAMEALNREQESARLQQRERE 307 L+ EE Q+ + + K +++ +L + L+ ++ ++ E A L+ + E Sbjct: 1176 SKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTE-ALLEAKTNE 1234 Query: 308 TLE---EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQT--- 361 + + A+ R+ Q R ++E A + ELE L EE+ T Sbjct: 1235 LINISSSKTNAILSRISHCQHRTTKVKE----ALLIKTCTVSELEAQLRQLTEEQNTLNI 1290 Query: 362 -WAQQEHQLKEHYQALQEESQ--AQLEREKEKSQREA----QAAWETQHQLALVQSEVRR 414 + Q HQL+E ++ L EKE Q+E QAA E + + ++ E+ Sbjct: 1291 SFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSE 1350 Query: 415 LEGELDTARRERDALQLEMSLVQARYESQRIQLESELAV------------QLEQRVTER 462 + + E ++E+S + + +QL++ +++ Q ++ E Sbjct: 1351 NINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCEL 1410 Query: 463 LAQAQESSLRQAASLRE----------------HHRKQLQDLSGQHQ------------- 493 L Q Q+ S + +E +K+ Q QHQ Sbjct: 1411 LDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELK 1470 Query: 494 ---------------QELASQLAQF---KVEMAEREERQQQVAEDYELRLAREQARVCEL 535 +EL Q +F K EM + + + ++ + E L + AR+ EL Sbjct: 1471 SKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMEL 1530 Query: 536 QSG------------------NQQLEEQRVELVERLQAMLQAHWDEANQL 567 + NQQ + + ELV++LQ + ++ N++ Sbjct: 1531 EDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580 Score = 46.6 bits (109), Expect = 1e-04 Identities = 80/411 (19%), Positives = 167/411 (40%), Gaps = 74/411 (18%) Query: 205 QSLQTRVLELQQQLAVAVAADR---------KKDTMIEQLDKTLARVVEGWNRHEAERTE 255 Q + +LQQ LA A A+ + + EQLD+ G + A++ + Sbjct: 7 QKISEEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQ 66 Query: 256 V----LRGLQEEHQAAELTRSKQQETVTRLEQSLSEAMEALNR-EQESARLQQRERETLE 310 + + L L RS +E++ R + + E+LNR + +S+ ++ Sbjct: 67 LRVPSVESLFRSPIKESLFRSSSKESLVR-----TSSRESLNRLDLDSSTASFDPPSDMD 121 Query: 311 EERQALTLRLEAEQQRCCVLQEERDAARAGQLSEHRELETLRAALEEERQTWAQQEHQLK 370 E + L + L++ + ++ LR +E ++ + +L Sbjct: 122 SEAEDLV-------------------GNSDSLNKEQLIQRLRR-MERSLSSYRGKYSELV 161 Query: 371 EHYQALQEES---QAQLEREKEKSQREAQAAWETQHQLALVQSEVRRLEGELDTARRERD 427 YQ LQ E Q L + ++KS R E + +L + Q + L+ E D + E+D Sbjct: 162 TAYQMLQREKKKLQGILSQSQDKSLRRIA---ELREELQMDQQAKKHLQEEFDASLEEKD 218 Query: 428 ----ALQLEMSLVQARYESQRI---------QLESELAVQLEQR---------VTERLAQ 465 LQ ++SL++ R + + QLE + V ++ V + + Sbjct: 219 QYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSV 278 Query: 466 AQESSLRQAASLREHHRKQLQDLSGQHQQELASQLAQFKVEMAEREERQQQVAEDYELRL 525 +L+Q +E+ K+ ++ H+++ ++ + + +ER Q++ + +L + Sbjct: 279 KTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHM 338 Query: 526 AREQARVCELQSGN---QQLEEQR----VELVERLQAMLQAHWDEANQLLS 569 A + + +L+ +QLE+ + E ++ L+ +E QL S Sbjct: 339 AEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.310 0.126 0.354 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 39,429,877 Number of Sequences: 37866 Number of extensions: 2227272 Number of successful extensions: 37287 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 489 Number of HSP's successfully gapped in prelim test: 1674 Number of HSP's that attempted gapping in prelim test: 16791 Number of HSP's gapped (non-prelim): 10247 length of query: 903 length of database: 18,247,518 effective HSP length: 111 effective length of query: 792 effective length of database: 14,044,392 effective search space: 11123158464 effective search space used: 11123158464 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.