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Search of human proteins with 190570174
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190570174 cytochrome P450, family 21, subfamily A,
polypeptide 2 isoform b [Homo sapiens]
(465 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid... 947 0.0
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide... 932 0.0
gi|4503195 cytochrome P450, family 17 [Homo sapiens] 202 5e-52
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ... 183 3e-46
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ... 182 6e-46
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ... 166 5e-41
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ... 163 3e-40
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ... 161 1e-39
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ... 159 4e-39
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1... 155 6e-38
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ... 154 1e-37
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1... 154 2e-37
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ... 153 3e-37
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ... 153 4e-37
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ... 151 1e-36
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ... 150 3e-36
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6... 140 3e-33
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ... 137 2e-32
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ... 127 2e-29
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide... 127 2e-29
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ... 124 1e-28
gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide... 122 7e-28
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ... 121 1e-27
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ... 116 5e-26
gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide ... 108 1e-23
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18... 107 2e-23
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ... 103 3e-22
gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide ... 103 3e-22
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5... 102 1e-21
gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide ... 102 1e-21
>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform b [Homo sapiens]
Length = 465
Score = 947 bits (2449), Expect = 0.0
Identities = 465/465 (100%), Positives = 465/465 (100%)
Query: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60
MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY
Sbjct: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60
Query: 61 RLHLGLQDKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCER 120
RLHLGLQDKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCER
Sbjct: 61 RLHLGLQDKLVSRNYPDLSLGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCER 120
Query: 121 MRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIV 180
MRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIV
Sbjct: 121 MRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSIQIV 180
Query: 181 DVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSM 240
DVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSM
Sbjct: 181 DVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSM 240
Query: 241 EEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGA 300
EEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGA
Sbjct: 241 EEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGA 300
Query: 301 SSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQ 360
SSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQ
Sbjct: 301 SSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQ 360
Query: 361 GAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF 420
GAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF
Sbjct: 361 GAHLDETVWERPHEFWPDRFLEPGKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF 420
Query: 421 TLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ 465
TLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ
Sbjct: 421 TLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQSQ 465
>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
isoform a [Homo sapiens]
Length = 495
Score = 932 bits (2408), Expect = 0.0
Identities = 465/495 (93%), Positives = 465/495 (93%), Gaps = 30/495 (6%)
Query: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60
MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY
Sbjct: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHLLQPDLPIYLLGLTQKFGPIY 60
Query: 61 RLHLGLQD------------------------------KLVSRNYPDLSLGDYSLLWKAH 90
RLHLGLQD KLVSRNYPDLSLGDYSLLWKAH
Sbjct: 61 RLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSLLWKAH 120
Query: 91 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 150
KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD
Sbjct: 121 KKLTRSALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 180
Query: 151 KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM 210
KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM
Sbjct: 181 KIKDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDHIVEM 240
Query: 211 QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT 270
QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT
Sbjct: 241 QLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANT 300
Query: 271 LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV 330
LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV
Sbjct: 301 LSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVV 360
Query: 331 PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL 390
PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL
Sbjct: 361 PLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRAL 420
Query: 391 AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR 450
AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR
Sbjct: 421 AFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVR 480
Query: 451 LQPRGMGAHSPGQSQ 465
LQPRGMGAHSPGQSQ
Sbjct: 481 LQPRGMGAHSPGQSQ 495
>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
Length = 508
Score = 202 bits (514), Expect = 5e-52
Identities = 137/454 (30%), Positives = 223/454 (49%), Gaps = 64/454 (14%)
Query: 52 LTQKFGPIYRLHLGLQDKLV------------------------------SRNYPDLSLG 81
L +K+GPIY + +G + ++ S N ++
Sbjct: 56 LQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFA 115
Query: 82 DYSLLWKAHKKLTRS--ALLLGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT 139
D W+ H++L + AL +E ++ Q C+ + G + I +
Sbjct: 116 DSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAV 175
Query: 140 CSIICYLTFGDKIKDD----NLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLR 195
++I + F K+ N++ Y + I + L S +VD++P+L+ FPN L
Sbjct: 176 TNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDS-----LVDLVPWLKIFPNKTLE 230
Query: 196 RLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQ-------GVAQPSMEEGSGQLL 248
+LK ++ R+ ++ L +KE + +M+D ++Q G A P ++ S L
Sbjct: 231 KLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGP--DQDSELLS 288
Query: 249 EGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-Y 307
+ H+ D+ G ETT + + W + FLLH+P+++++L EE+D +G SR P
Sbjct: 289 DNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVG----FSRTPTI 344
Query: 308 KDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDET 367
DR RL LL ATI EVLRLRPV P+ +PH+ SSI + + +GT +I NL H +E
Sbjct: 345 SDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEK 404
Query: 368 VWERPHEFWPDRFLEP------GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFT 421
W +P +F P+RFL P + L FG G R C+GE LAR ELF+++ LLQ F
Sbjct: 405 EWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFD 464
Query: 422 L-LPSGDALPSLQPLPHCSVILKMQPFQVRLQPR 454
L +P LPSL+ +P V+ + F+V+++ R
Sbjct: 465 LEVPDDGQLPSLEGIP--KVVFLIDSFKVKIKVR 496
>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
[Homo sapiens]
Length = 544
Score = 183 bits (464), Expect = 3e-46
Identities = 114/381 (29%), Positives = 193/381 (50%), Gaps = 15/381 (3%)
Query: 83 YSLLWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLT 139
Y +W+ +K + S L LG + S+EP + + + M+ P S
Sbjct: 170 YGPVWRQQRKFSHSTLRHFGLG-KLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAV 228
Query: 140 CSIICYLTFGDKIKDDNL-MPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLK 198
+IIC L FG + N + L+ + + +V++ P+L + P + L+
Sbjct: 229 SNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELR 288
Query: 199 QAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVD 258
Q + ++ ++ H+ESL +D +D L + + + E ++ D
Sbjct: 289 QIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGD 348
Query: 259 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 318
L I GT+TT N+L W ++++ +P++Q+++ EE++ +G + S D+A++P A
Sbjct: 349 LFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLT---DKAQMPYTEA 405
Query: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378
TI EV RL VVPLA+PH T+ + + GY IP+GT+I+PNL H D +WE+P +F+P+
Sbjct: 406 TIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPN 465
Query: 379 RFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL-LPSGDALPSLQ 433
RFL+ K + FG G RVC+GE LA++ELF++ L+Q+F LP P L
Sbjct: 466 RFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLL- 524
Query: 434 PLPHCSVILKMQPFQVRLQPR 454
+ L PF + + R
Sbjct: 525 -TGRFGLTLAPHPFNITISRR 544
>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
[Homo sapiens]
Length = 502
Score = 182 bits (462), Expect = 6e-46
Identities = 122/393 (31%), Positives = 203/393 (51%), Gaps = 19/393 (4%)
Query: 49 LLGLTQKFGPIYRLHLGLQDKLVSRNYPDLSLGDYSLLWKAHKKLTRSALL---LGIRDS 105
L+ + Q FG R +++ + +N +S G WK ++ T +AL LG + S
Sbjct: 101 LIHMDQNFGN--RPVTPMREHIFKKNGLIMSSGQ---AWKEQRRFTLTALRNFGLG-KKS 154
Query: 106 MEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKC 164
+E +++ Q E ++ + G P + + +IIC +TFG++ + D+ K
Sbjct: 155 LEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKL 214
Query: 165 IQEVLKTWSHWSIQIVDVIPFL-RFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQ 223
+ EV + + Q+ +V P++ +F P P + L +K V + +H++ +
Sbjct: 215 LDEVTYLEASKTCQLYNVFPWIMKFLPGPH-QTLFSNWKKLKLFVSHMIDKHRKDWNPAE 273
Query: 224 WRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPE 283
RD +D L+ +++ + S E ++ + +DL GTETT+ TL WA++++ +PE
Sbjct: 274 TRDFIDAYLKEMSKHTGNPTSS-FHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPE 332
Query: 284 IQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSS 343
IQ+++Q E+D +G G S R +P NA I EV R+ ++PL +P T ++
Sbjct: 333 IQEKVQAEIDRVIGQGQQPSTAA---RESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTT 389
Query: 344 ISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPG---KNSRALAFGCGARVCL 400
++GY +P+GT+I+ NL H D T W P F PD FLE G K + F G R CL
Sbjct: 390 LAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACL 449
Query: 401 GEPLARLELFVVLTRLLQAFTLLPSGDALPSLQ 433
GE LAR ELF+ T L+Q FT P + SL+
Sbjct: 450 GEQLARTELFIFFTSLMQKFTFRPPNNEKLSLK 482
>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
[Homo sapiens]
Length = 491
Score = 166 bits (419), Expect = 5e-41
Identities = 148/497 (29%), Positives = 232/497 (46%), Gaps = 63/497 (12%)
Query: 8 LLLPLLAGARLLWNWWKLRSLHLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPIYR 61
+LL LLA LL LPP + L L D+ L L++++G +Y
Sbjct: 8 ILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYT 67
Query: 62 LHLG------------LQDKLVSRNYPDLSLGDYSLL----------------WKAHKKL 93
+HLG +++ LV + GDY WK ++
Sbjct: 68 VHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQF 127
Query: 94 TRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGD 150
+ L +G R E ++E+ + E +R G P S +IIC + FG
Sbjct: 128 SIQILRNFGMGKRSIEERILEEGSFLLAE-LRKTEGEPFDPTFVLSRSVSNIICSVLFGS 186
Query: 151 KIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIV 208
+ DD + + I + + S ++ D+ P L + P P R + RD ++
Sbjct: 187 RFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRD-LI 245
Query: 209 EMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAV-----DLLIGG 263
+ H+ SL RD + L +A+ + S H HM + +LL GG
Sbjct: 246 AHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLS------HFHMDTLLMTTHNLLFGG 299
Query: 264 TETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAE 322
T+T + TL A + L+ +P++Q R+QEE+D +G +R+P KDRA +P +A I E
Sbjct: 300 TKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVG----RARLPALKDRAAMPYTDAVIHE 355
Query: 323 VLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLE 382
V R ++P+ LPHR TR ++ G+ IP+GT +I L H D + + P EF P+ FL+
Sbjct: 356 VQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLD 415
Query: 383 PG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHC 438
K+ + F G R+CLGE LAR+ELF+ LT +LQ+F+L P G A + P
Sbjct: 416 ANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLG-APEDIDLTPLS 474
Query: 439 SVILKM-QPFQVRLQPR 454
S + + +PFQ+ L+PR
Sbjct: 475 SGLGNLPRPFQLCLRPR 491
>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
[Homo sapiens]
Length = 493
Score = 163 bits (413), Expect = 3e-40
Identities = 132/473 (27%), Positives = 219/473 (46%), Gaps = 54/473 (11%)
Query: 1 MLLLGLLLLLPLLAGARLLWNWWKL--RSLHLPP------LAPGFLHLLQPDLPIYLLGL 52
M LG+ + L + A LL + W+ S +LPP + L ++P L
Sbjct: 1 MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRL 60
Query: 53 TQKFGPIYRLHLGLQDKLVSRNYPDL--SLGDYS-------------------------L 85
Q+FGP++ L++G Q +V Y + +L DY
Sbjct: 61 AQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGP 120
Query: 86 LWKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 142
WK ++ + + L +G + E +++ E +R G P C++
Sbjct: 121 TWKDIRRFSLTTLRNYGMG-KQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNV 179
Query: 143 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQ 199
I + F D+ + Y + + W +Q+ + P FL + P + +K
Sbjct: 180 IADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPW-LQLYNNFPSFLHYLPGSHRKVIKN 238
Query: 200 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 259
E ++++ E ++++H +SL RD+ D +L + + ++G + + DL
Sbjct: 239 VAEVKEYVSE-RVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDG-ITVTVADL 296
Query: 260 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNA 318
GTETT+ TL + ++ L+ +PEI+++L EE+D +GP SR+P KDR +P ++A
Sbjct: 297 FFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGP----SRIPAIKDRQEMPYMDA 352
Query: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378
+ E+ R +VP LPH TR + GY IP+GTV++P L D + P +F P+
Sbjct: 353 VVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPE 412
Query: 379 RFL-EPGK---NSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGD 427
FL E GK + F G RVC GE LAR+ELF++L +LQ F L P D
Sbjct: 413 HFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVD 465
>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
[Homo sapiens]
Length = 504
Score = 161 bits (408), Expect = 1e-39
Identities = 148/512 (28%), Positives = 238/512 (46%), Gaps = 64/512 (12%)
Query: 1 MLLLGLLLLLPL-LAGARLLWNWWKLRSLHLPP------LAPGFLHLLQPDLPIYLLGLT 53
+L L LLLLL L L+G R HLPP L L L L L+ L+
Sbjct: 10 LLALALLLLLTLALSGTRARG--------HLPPGPTPLPLLGNLLQLRPGALYSGLMRLS 61
Query: 54 QKFGPIYRLHLG-------------LQDKLVSRNYPDLSLGDYSLL-------------- 86
+K+GP++ ++LG +++ L + G ++L
Sbjct: 62 KKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNG 121
Query: 87 --WKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCS 141
W+ +K T AL +G R+ E +++ + E + G P + T +
Sbjct: 122 ERWRQLRKFTMLALRDLGMGKREG-EELIQAEARCLVETFQGTEGRPFDPSLLLAQATSN 180
Query: 142 IICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQ 199
++C L FG + +D A + L S Q ++ FLR P P ++L
Sbjct: 181 VVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPH-KQLLH 239
Query: 200 AIEKRDHIVEMQLRQHKESLVA-GQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVD 258
+ Q++QH+ +L A G RD++D L +AQ G+ + ++ M +
Sbjct: 240 HVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGT-EFTNKNMLMTVIY 298
Query: 259 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 318
LL GT T + T+ + ++ L+ +P +Q+ ++EEL+ ELG G + S DR RLP +A
Sbjct: 299 LLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPS---LGDRTRLPYTDA 355
Query: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378
+ E RL +VP+ +P R + GY +P+GT + P L D +++ P EF PD
Sbjct: 356 VLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPD 415
Query: 379 RFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQP 434
RFL+ K+ L F G RVCLGE LA+ ELF+ T +LQAF+ L S +L
Sbjct: 416 RFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFS-LESPCPPDTLSL 474
Query: 435 LPHCSVILKMQP-FQVRLQPRGMGAHSPGQSQ 465
P S + + P FQ++++P + HS Q++
Sbjct: 475 KPTVSGLFNIPPAFQLQVRPTDL--HSTTQTR 504
>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
[Homo sapiens]
Length = 501
Score = 159 bits (403), Expect = 4e-39
Identities = 142/505 (28%), Positives = 220/505 (43%), Gaps = 74/505 (14%)
Query: 5 GLLLLLPLLAGARLLWNWWKLRSLHLPPLAPGFLHL-------LQPDLP-IYLLGLTQKF 56
G L LL G R L + R + PP PG + +LP +Y+ +Q +
Sbjct: 16 GALFLLLFALGVRQLLK--QRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVY 73
Query: 57 GPIYRLHLGLQDKLVSRNY-----------------PDLSL------------GDYSLLW 87
G I+ L LG +V Y P L L Y W
Sbjct: 74 GEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGW 133
Query: 88 KAHKKLT-RSALLLGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICY 145
H++L S G + S E + + T+ F + + G P ++ + +I
Sbjct: 134 VDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFKQLITNAVSNITNL 193
Query: 146 LTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFP---NPGLRR----- 196
+ FG++ +D + E ++ + S+ + + P++ P + L R
Sbjct: 194 IIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPFGKHQQLFRNAAVV 253
Query: 197 ---LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVH 253
L + IEK + QL QH + D MD QG PS L+
Sbjct: 254 YDFLSRLIEKASVNRKPQLPQH----FVDAYLDEMD---QGKNDPSSTFSKENLI----- 301
Query: 254 MAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARL 313
+ +L+I GTETT N L WA++F+ +P IQ ++Q+E+D +GP S + D+ ++
Sbjct: 302 FSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPS---WDDKCKM 358
Query: 314 PLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPH 373
P A + EVLR +VPL + H T+ + + GY IP+GT +I NL H DE W P
Sbjct: 359 PYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPE 418
Query: 374 EFWPDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDAL 429
F P+RFL+ K + F G R CLGE LAR+E+F+ T LLQ F L + +
Sbjct: 419 VFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELV 478
Query: 430 PSLQPLPHCSVILKMQPFQVRLQPR 454
P L+ P + L+ QP+ + + R
Sbjct: 479 PDLK--PRLGMTLQPQPYLICAERR 501
>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
[Homo sapiens]
Length = 512
Score = 155 bits (393), Expect = 6e-38
Identities = 83/245 (33%), Positives = 134/245 (54%), Gaps = 10/245 (4%)
Query: 181 DVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSM 240
D IP LR+ PNP L K EK ++ +++H ++ G RD+ D +++ + +
Sbjct: 235 DFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQL 294
Query: 241 EEGSG-QLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 299
+E + QL + + +DL G +T +SW++++L+ +P +Q+++QEELD +G
Sbjct: 295 DENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIG-- 352
Query: 300 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 359
S R DR+ LP + A I E R VP +PH TTR +S+ G+ IP+G + N
Sbjct: 353 -RSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQ 411
Query: 360 QGAHLDETVWERPHEFWPDRFLEPG------KNSRALAFGCGARVCLGEPLARLELFVVL 413
+ D+ +W P EF P+RFL P + + + FG G R C+GE +AR E+F+ L
Sbjct: 412 WQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFL 471
Query: 414 TRLLQ 418
LLQ
Sbjct: 472 AILLQ 476
>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
isoform 1 [Homo sapiens]
Length = 497
Score = 154 bits (390), Expect = 1e-37
Identities = 114/370 (30%), Positives = 179/370 (48%), Gaps = 32/370 (8%)
Query: 80 LGDYSLLWKAHKKLTRSALL-LGI-RDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSL 137
L Y W+ ++ + S L LG+ + S+E V + C G P
Sbjct: 121 LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK 180
Query: 138 LTCSIICYLTFGDKIKDDNLMPAYYKCI---QEVLKTWSHWSIQIVDVIPFLRFFP---N 191
++I LT G + + D+ P + + + QE LK S + ++++ +P L P
Sbjct: 181 AVSNVIASLTCGRRFEYDD--PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAG 238
Query: 192 PGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGSGQ---- 246
LR K + + D + L +H+ + Q RD+ + L ME+ G
Sbjct: 239 KVLRFQKAFLTQLDEL----LTEHRMTWDPAQPPRDLTEAFLA-----EMEKAKGNPESS 289
Query: 247 LLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP 306
+ ++ + DL G TT+ TL+W ++ ++ HP++Q+R+Q+E+D +G R
Sbjct: 290 FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIG---QVRRPE 346
Query: 307 YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDE 366
D+A +P A I EV R +VPL + H T+R + G+ IP+GT +I NL DE
Sbjct: 347 MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 406
Query: 367 TVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 422
VWE+P F P+ FL+ K L F G R CLGEPLAR+ELF+ T LLQ F+
Sbjct: 407 AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 466
Query: 423 -LPSGDALPS 431
+P+G PS
Sbjct: 467 SVPTGQPRPS 476
>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
[Homo sapiens]
Length = 490
Score = 154 bits (388), Expect = 2e-37
Identities = 122/428 (28%), Positives = 201/428 (46%), Gaps = 43/428 (10%)
Query: 32 PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDKLVSRNYP-------DLS----- 79
P+ L + D+ L L++ +GP++ L+ GL+ +V Y DL
Sbjct: 37 PVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSG 96
Query: 80 LGDYSLLWKAHK------------KLTRSALLLGIRD------SMEPVVEQLTQEFCERM 121
G + L +A++ K R L+ +R+ S+E V++ + E +
Sbjct: 97 RGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEEL 156
Query: 122 RAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQI 179
R +P C++IC + F + KD + K + + + W IQI
Sbjct: 157 RKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPW-IQI 215
Query: 180 VDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQP 238
+ P + +FP + LK I+E ++++H+ES+ RD +D L + +
Sbjct: 216 CNNFPTIIDYFPGTHNKLLKNLAFMESDILE-KVKEHQESMDINNPRDFIDCFLIKMEKE 274
Query: 239 SMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGP 298
+ S +E V + A DLL GTETT+ TL +A++ LL HPE+ ++QEE++ +G
Sbjct: 275 KQNQQSEFTIENLV-ITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGR 333
Query: 299 GASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPN 358
S +DR +P +A + EV R ++P +LPH T Y IP+GT I+ +
Sbjct: 334 NRSPCM---QDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTS 390
Query: 359 LQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLT 414
L D + P F P FL+ G K++ + F G R+C+GE LAR+ELF+ LT
Sbjct: 391 LTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLT 450
Query: 415 RLLQAFTL 422
+LQ F L
Sbjct: 451 FILQNFNL 458
>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
[Homo sapiens]
Length = 490
Score = 153 bits (387), Expect = 3e-37
Identities = 125/460 (27%), Positives = 212/460 (46%), Gaps = 49/460 (10%)
Query: 7 LLLLPLLAGARLLWNWWKLRSLH--LPP------LAPGFLHLLQPDLPIYLLGLTQKFGP 58
L++L L LL + W+ S LPP + L + D+ L L++ +GP
Sbjct: 4 LVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGP 63
Query: 59 IYRLHLGLQDKLVSRNYPD-----LSLGD-------YSLLWKAHK------------KLT 94
++ L+ GL+ +V Y + LG+ + L +A++ K
Sbjct: 64 VFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEI 123
Query: 95 RSALLLGIRD------SMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTF 148
R L+ +R+ S+E V++ + E +R +P C++IC + F
Sbjct: 124 RRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIF 183
Query: 149 GDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEKRDH 206
+ KD + K + + S W + P + +FP + LK + +
Sbjct: 184 HKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSY 243
Query: 207 IVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTET 266
I+E ++++H+ES+ +D +D L + + + S +E + AVDL GTET
Sbjct: 244 ILE-KVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIES-LENTAVDLFGAGTET 301
Query: 267 TANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRL 326
T+ TL +A++ LL HPE+ ++QEE++ +G S +DR+ +P +A + EV R
Sbjct: 302 TSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCM---QDRSHMPYTDAVVHEVQRY 358
Query: 327 RPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKN 386
++P +LPH T Y IP+GT I+ +L D + P F P FL+ G N
Sbjct: 359 IDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGN 418
Query: 387 SRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 422
+ + F G R+C+GE LA +ELF+ LT +LQ F L
Sbjct: 419 FKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNL 458
>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
[Homo sapiens]
Length = 490
Score = 153 bits (386), Expect = 4e-37
Identities = 132/441 (29%), Positives = 207/441 (46%), Gaps = 62/441 (14%)
Query: 36 GFLHLLQ-PDLPIYLLGLTQKFGPIYRLHLGLQDKLVSRNY---------PDLSLGD--- 82
G LHLL+ L+ L++++GP++ +HLG Q +V + P L D
Sbjct: 42 GNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPP 101
Query: 83 ---YSLL-------------WKAHKKLTRSAL-LLGIRDSMEPVVEQLTQEF------CE 119
+ L+ W+A ++ T AL LG+ EPV +++ QE +
Sbjct: 102 IAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGV--GREPVADKILQELKCLSGQLD 159
Query: 120 RMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQ 178
R +P P+A+ +I L FG + D + + I EV+ +Q
Sbjct: 160 GYRGRP-FPLAL---LGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQ 215
Query: 179 IVDVIPFLRFF---PNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGV 235
+ +V P+L P LR+ IE+ I+ L + + G + Y+ +
Sbjct: 216 LFNVYPWLGALLQLHRPVLRK----IEEVRAILRTLLEARRPHVCPGD--PVCSYVDALI 269
Query: 236 AQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHE 295
Q ++ G E + +D+++ GTETT+ TL WA + + HP++Q R+QEELD
Sbjct: 270 QQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRV 329
Query: 296 LGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTV 354
LGPG R P +D+ LP +A + EV R ++P +P T + + G+ +P+GT
Sbjct: 330 LGPG----RTPRLEDQQALPYTSAVLHEVQRFITLLP-HVPRCTAADTQLGGFLLPKGTP 384
Query: 355 IIPNLQGAHLDETVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELF 410
+IP L LDET W+ P +F P FL+ K L F G RVC+GE LAR ELF
Sbjct: 385 VIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELF 444
Query: 411 VVLTRLLQAFTLLPSGDALPS 431
++ LLQ + LLP P+
Sbjct: 445 LLFAGLLQRYRLLPPPGVSPA 465
>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
isoform 2 [Homo sapiens]
Length = 446
Score = 151 bits (381), Expect = 1e-36
Identities = 126/430 (29%), Positives = 199/430 (46%), Gaps = 54/430 (12%)
Query: 23 WKLRSLHLPPLAPGFLHLLQPDL---PIYLLGLTQKFGPIYRLHLGLQDKLVSRNYPDLS 79
W R P PG +LL D P L ++FG ++ L L +V +
Sbjct: 29 WAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAV- 87
Query: 80 LGDYSLLWKAHKKLTRSALLLGIRDSMEPVVEQLTQ--EFCERMRAQPGTPVAIEEEFSL 137
R AL+ D+ + +TQ F R + +P P + ++
Sbjct: 88 ---------------REALVTHGEDTADRPPVPITQILGFGPRSQGRPFRPNGLLDK--- 129
Query: 138 LTCSIICYLTFGDKIKDDNLMPAYYKCI---QEVLKTWSHWSIQIVDVIPFLRFFP---N 191
++I LT G + + D+ P + + + QE LK S + ++++ +P L P
Sbjct: 130 AVSNVIASLTCGRRFEYDD--PRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAG 187
Query: 192 PGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEEGSGQ---- 246
LR K + + D + L +H+ + Q RD+ + L ME+ G
Sbjct: 188 KVLRFQKAFLTQLDEL----LTEHRMTWDPAQPPRDLTEAFLA-----EMEKAKGNPESS 238
Query: 247 LLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP 306
+ ++ + DL G TT+ TL+W ++ ++ HP++Q+R+Q+E+D +G R
Sbjct: 239 FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIG---QVRRPE 295
Query: 307 YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDE 366
D+A +P A I EV R +VPL + H T+R + G+ IP+GT +I NL DE
Sbjct: 296 MGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDE 355
Query: 367 TVWERPHEFWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTL 422
VWE+P F P+ FL+ K L F G R CLGEPLAR+ELF+ T LLQ F+
Sbjct: 356 AVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSF 415
Query: 423 -LPSGDALPS 431
+P+G PS
Sbjct: 416 SVPTGQPRPS 425
>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
[Homo sapiens]
Length = 490
Score = 150 bits (378), Expect = 3e-36
Identities = 133/485 (27%), Positives = 214/485 (44%), Gaps = 54/485 (11%)
Query: 8 LLLPLLAGARLLWNWWK--LRSLHLPP------LAPGFLHLLQPDLPIYLLGLTQKFGPI 59
++L L LL++ W+ R LPP + L + D+ ++ +GP+
Sbjct: 5 VVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPV 64
Query: 60 YRLHLGLQDKLVSRNYPDLS-------------------------LGDYSLLWKAHKKLT 94
+ ++ G+ +V Y + LG S K K++
Sbjct: 65 FTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIR 124
Query: 95 RSALL------LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSIICYLTF 148
R +L +G R S+E V++ E +R +P C++IC + F
Sbjct: 125 RFSLTTLRNFGMGKR-SIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVF 183
Query: 149 GDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFL-RFFPNPGLRRLKQAIEKRD 205
+ KD N + + + S W IQ+ + P L FP + LK R
Sbjct: 184 QKRFDYKDQNFLTLMKRFNENFRILNSPW-IQVCNNFPLLIDCFPGTHNKVLKNVALTRS 242
Query: 206 HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTE 265
+I E ++++H+ SL RD +D L + Q + S +E V A DL + GTE
Sbjct: 243 YIRE-KVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVA-DLFVAGTE 300
Query: 266 TTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLR 325
TT+ TL + ++ LL HPE+ ++QEE+DH +G S +DR+ +P +A + E+ R
Sbjct: 301 TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPC---MQDRSHMPYTDAVVHEIQR 357
Query: 326 LRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGK 385
+VP +PH T + Y IP+GT I+ L D+ + P+ F P FL+
Sbjct: 358 YSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNG 417
Query: 386 NSRA----LAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVI 441
N + + F G R+C GE LAR+ELF+ LT +LQ F L S D L +L I
Sbjct: 418 NFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFN-LKSVDDLKNLNTTAVTKGI 476
Query: 442 LKMQP 446
+ + P
Sbjct: 477 VSLPP 481
>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
[Homo sapiens]
Length = 491
Score = 140 bits (352), Expect = 3e-33
Identities = 134/505 (26%), Positives = 234/505 (46%), Gaps = 70/505 (13%)
Query: 4 LGLLLLLPLLAGARLLWNWWKLRSLH------LPP---LAPGFLHLLQPD---LPIYLLG 51
L +LL L LL G LL L H LPP P +LLQ D L L
Sbjct: 3 LSVLLFLALLTGLLLL-----LVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLR 57
Query: 52 LTQKFGPIYRLHLG------------LQDKLVSRNYPDLSLGDYSLL------------- 86
+K+G ++ +HLG +++ LV + G +++
Sbjct: 58 FREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN 117
Query: 87 ---WKAHKKLTRSALL---LGIRDSMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 140
WK ++ + + + +G R S+E +++ Q E +R G + F +T
Sbjct: 118 GNRWKVLRRFSVTTMRDFGMGKR-SVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITA 176
Query: 141 SIICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI---QIVDVIP-FLRFFPNPGLRR 196
+IIC + FG + + + K + +T+S S Q+ ++ FL++FP R+
Sbjct: 177 NIICSIVFGKRFHYQD--QEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAH-RQ 233
Query: 197 LKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMD-YMLQGVAQPSMEEGSGQLLEGHVHMA 255
+ + +++ + + + +H+E+L +D++D Y+L + S + ++++
Sbjct: 234 VYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKS--NAHSEFSHQNLNLN 291
Query: 256 AVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLP 314
+ L GTETT+ TL + + +L +P + +R+ E++ +GP R P DRA++P
Sbjct: 292 TLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGP----HRPPELHDRAKMP 347
Query: 315 LLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHE 374
A I E+ R ++P+ +PH T+ +S GY IP+ T + L A D +E+P
Sbjct: 348 YTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDA 407
Query: 375 FWPDRFLEPG----KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALP 430
F PD FL+ K + F G R+CLGE +AR ELF+ T +LQ F+ + S A
Sbjct: 408 FNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFS-MASPVAPE 466
Query: 431 SLQPLPHCSVILKMQP-FQVRLQPR 454
+ P + K+ P +Q+R PR
Sbjct: 467 DIDLTPQECGVGKIPPTYQIRFLPR 491
>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 1 [Homo sapiens]
Length = 490
Score = 137 bits (345), Expect = 2e-32
Identities = 112/431 (25%), Positives = 197/431 (45%), Gaps = 49/431 (11%)
Query: 32 PLAPGFLHLLQPDLPIYLLGLTQKFGPIYRLHLGLQDKLVSRNYPDLS------------ 79
P+ L L D+ L ++ +GP++ ++ GL+ +V Y +
Sbjct: 37 PIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSG 96
Query: 80 LGDYSLLWKAHKKL------------TRSALLLGIRD------SMEPVVEQLTQEFCERM 121
G + + K +K L R L+ +R+ S+E V++ + E +
Sbjct: 97 RGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEEL 156
Query: 122 RAQPGTPVAIEEEFSLLTCSIICYLTFGDKI--KDD---NLMPAYYKCIQEVLKTWSHWS 176
R +P C++IC + F D+ KD NLM + + ++ + W
Sbjct: 157 RKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPW---- 212
Query: 177 IQIVDVIPFL-RFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGV 235
IQ+ + P L + P + + + +++E ++++H+ESL RD +D L +
Sbjct: 213 IQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLE-RIKEHQESLDMNSARDFIDCFLIKM 271
Query: 236 AQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHE 295
Q + S +E + D+ GTETT+ TL + ++ LL +PE+ ++QEE++
Sbjct: 272 EQEKHNQQSEFTVESLI-ATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECV 330
Query: 296 LGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVI 355
+G S +DR+ +P +A + E+ R ++P LPH T Y IP+GT I
Sbjct: 331 VGRNRSPCM---QDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTI 387
Query: 356 IPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPLARLELFV 411
I +L ++ + P F P FL+ N + + F G R+C+GE LAR+ELF+
Sbjct: 388 ITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFL 447
Query: 412 VLTRLLQAFTL 422
LT +LQ F L
Sbjct: 448 FLTTILQNFNL 458
>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
[Homo sapiens]
Length = 516
Score = 127 bits (320), Expect = 2e-29
Identities = 76/246 (30%), Positives = 127/246 (51%), Gaps = 11/246 (4%)
Query: 180 VDVIPFLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPS 239
+D P LR+ PNP L+R K ++ ++ +++H + RD+ + + +
Sbjct: 236 LDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGP 295
Query: 240 MEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPG 299
G+ E V++ D+ G +T +SW++++L+ PEIQ+++Q+ELD +G
Sbjct: 296 RASGNLIPQEKIVNLVN-DIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIG-- 352
Query: 300 ASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNL 359
R DR +LP L A I E R +P +PH TTR ++++G+ IP+ + N
Sbjct: 353 -RERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQ 411
Query: 360 QGAHLDETVWERPHEFWPDRFL-------EPGKNSRALAFGCGARVCLGEPLARLELFVV 412
+ D +WE P EF P+RFL + + + FG G R C+GE LA+ E+F+
Sbjct: 412 WQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLF 471
Query: 413 LTRLLQ 418
L LLQ
Sbjct: 472 LAILLQ 477
>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
[Homo sapiens]
Length = 494
Score = 127 bits (320), Expect = 2e-29
Identities = 113/471 (23%), Positives = 219/471 (46%), Gaps = 57/471 (12%)
Query: 1 MLLLGLLLLLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLGLT 53
MLL+ LL+ L ++ L+ W + +S P P +L L + L+ ++
Sbjct: 6 MLLVALLVCLTVMV---LMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKIS 62
Query: 54 QKFGPIYRLHLG------------LQDKLVSRNYPDLSLGD---YSLLWKAH-------- 90
+++GP++ +HLG +++ LV + G+ + ++K +
Sbjct: 63 ERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGE 122
Query: 91 --KKLTRSALLLGIRD------SMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTCSI 142
K+L R ++ +RD +E +++ + +R G + S ++
Sbjct: 123 RAKQLRRFSIAT-LRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNV 181
Query: 143 ICYLTFGDKI--KDDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQ 199
I + FGD+ KD + + + + + + S + Q+ ++ ++ P P + Q
Sbjct: 182 ISSIVFGDRFDYKDKEFL-SLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF-Q 239
Query: 200 AIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDL 259
++ + + ++ ++ +L RD +D L + + + L+ V M ++L
Sbjct: 240 LLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLV-MTTLNL 298
Query: 260 LIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNA 318
IGGTET + TL + + L+ HPE++ ++ EE+D +G +R P ++DRA++P + A
Sbjct: 299 FIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRAKMPYMEA 354
Query: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378
I E+ R V+P++L R + + + +P+GT + P L D + + P +F P
Sbjct: 355 VIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQ 414
Query: 379 RFL-EPG---KNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 425
FL E G K+ + F G R C GE LAR+ELF+ T ++Q F L S
Sbjct: 415 HFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 465
>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
[Homo sapiens]
Length = 494
Score = 124 bits (312), Expect = 1e-28
Identities = 112/468 (23%), Positives = 211/468 (45%), Gaps = 56/468 (11%)
Query: 1 MLLLGLLL--LLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLG 51
ML GLLL LL L L+ W + +S P P +L L + L+
Sbjct: 1 MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMK 60
Query: 52 LTQKFGPIYRLHLG------------LQDKLVSRNYPDLSLGD---YSLLWKAH------ 90
+++++GP++ +HLG +++ LV + G+ + L+K +
Sbjct: 61 ISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN 120
Query: 91 ----KKLTRSAL--LLGIRDSMEPVVEQLTQE---FCERMRAQPGTPVAIEEEFSLLTCS 141
K+L R ++ L G + E++ +E + +R G + S +
Sbjct: 121 GERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSN 180
Query: 142 IICYLTFGDKIKDDNLMPAYYKCIQEVLKTWSHWSI---QIVDVIP-FLRFFPNPGLRRL 197
+I + FGD+ ++ + ++ +L ++ + Q+ ++ ++ P P +
Sbjct: 181 VISSIVFGDRFDYED--KEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAF 238
Query: 198 KQAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAV 257
K+ D I + ++ ++ +L RD +D L + + + L+ V M +
Sbjct: 239 KELQGLEDFIAK-KVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLV-MTTL 296
Query: 258 DLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLL 316
+L GTET + TL + + L+ HPE++ ++ EE+D +G +R P ++DRA++P
Sbjct: 297 NLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRAKMPYT 352
Query: 317 NATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFW 376
A I E+ R ++P+ L HR + + + +P+GT + P L D + P +F
Sbjct: 353 EAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFN 412
Query: 377 PDRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAF 420
P FL+ K+ + F G R C GE LAR+ELF+ T ++Q F
Sbjct: 413 PQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNF 460
>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
[Homo sapiens]
Length = 543
Score = 122 bits (306), Expect = 7e-28
Identities = 80/252 (31%), Positives = 129/252 (51%), Gaps = 18/252 (7%)
Query: 179 IVDVIPFLRFFPNPG---LRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQG 234
+VDV+P+L++FPNP R +Q + + + +H ESL G RDMMD +
Sbjct: 240 LVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILS 299
Query: 235 VAQPSMEE--GSGQLLEGHVHMAAVDLLIGGTETTANT-LSWAVVFLLHHPEIQQRLQEE 291
+ + + G G L+ A + + G ++ T +T L W ++ +P++Q R+Q E
Sbjct: 300 AEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAE 359
Query: 292 LDHELGPGASSSRVPYK-DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIP 350
LD +G R+P D+ LP + A + E +R VP+ +PH TT +S+ GY IP
Sbjct: 360 LDQVVG----RDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIP 415
Query: 351 EGTVIIPNLQGAHLDETVWERPHEFWPDRFLE------PGKNSRALAFGCGARVCLGEPL 404
+ TV+ N + D W P F P RFL+ SR + F G R C+GE L
Sbjct: 416 KDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEEL 475
Query: 405 ARLELFVVLTRL 416
++++LF+ ++ L
Sbjct: 476 SKMQLFLFISIL 487
>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 1 [Homo sapiens]
Length = 494
Score = 121 bits (304), Expect = 1e-27
Identities = 110/472 (23%), Positives = 215/472 (45%), Gaps = 54/472 (11%)
Query: 1 MLLLGLLL--LLPLLAGARLLWNWWKLRSLHLPPLAP-------GFLHLLQPDLPIYLLG 51
ML GLLL LL L L+ W + +S P P +L L + ++
Sbjct: 1 MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMK 60
Query: 52 LTQKFGPIYRLHLG------------LQDKLVSRNYPDLSLGD---YSLLWKAH------ 90
++ +GP++ +HLG +++ LV + G+ + ++K +
Sbjct: 61 FSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN 120
Query: 91 ----KKLTRSALLLGIRD------SMEPVVEQLTQEFCERMRAQPGTPVAIEEEFSLLTC 140
K+L R A+ +RD +E +++ + E +R+ G + S
Sbjct: 121 GERAKQLLRFAIAT-LRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVS 179
Query: 141 SIICYLTFGDKIK-DDNLMPAYYKCIQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLK 198
++I + FGD+ +D + + + + S + Q+ ++ ++ P P + K
Sbjct: 180 NVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFK 239
Query: 199 QAIEKRDHIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVD 258
++ + + ++ ++ +L +D +D L + + + L+ ++ M+ ++
Sbjct: 240 -LLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLK-NLMMSTLN 297
Query: 259 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVP-YKDRARLPLLN 317
L I GTET + TL + + L+ HPE++ ++ EE+D +G +R P ++DR ++P +
Sbjct: 298 LFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIG----KNRQPKFEDRTKMPYME 353
Query: 318 ATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWP 377
A I E+ R V+P++L R + + + +P+GT + P L D + + P +F P
Sbjct: 354 AVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNP 413
Query: 378 DRFLEP----GKNSRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPS 425
FL+ K+ + F G R C GE LAR+ELF+ T ++Q F L S
Sbjct: 414 QHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSS 465
>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
isoform 2 [Homo sapiens]
Length = 443
Score = 116 bits (290), Expect = 5e-26
Identities = 81/327 (24%), Positives = 158/327 (48%), Gaps = 17/327 (5%)
Query: 110 VEQLTQE----FCERMRAQPGTPVAIEEEFSLLTCSIICYLTFGDKIK-DDNLMPAYYKC 164
+E+ QE E +R+ G + S ++I + FGD+ +D +
Sbjct: 94 IEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSM 153
Query: 165 IQEVLKTWSHWSIQIVDVIP-FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAGQ 223
+ + + S + Q+ ++ ++ P P + K ++ + + ++ ++ +L
Sbjct: 154 MLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFK-LLQGLEDFIAKKVEHNQRTLDPNS 212
Query: 224 WRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPE 283
+D +D L + + + L+ ++ M+ ++L I GTET + TL + + L+ HPE
Sbjct: 213 PQDFIDSFLIHMQEEEKNPNTEFYLK-NLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPE 271
Query: 284 IQQRLQEELDHELGPGASSSRVP-YKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPS 342
++ ++ EE+D +G +R P ++DR ++P + A I E+ R V+P++L R + +
Sbjct: 272 VEAKVHEEIDRVIG----KNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDT 327
Query: 343 SISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEP----GKNSRALAFGCGARV 398
+ +P+GT + P L D + + P +F P FL+ K+ + F G R
Sbjct: 328 KFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRN 387
Query: 399 CLGEPLARLELFVVLTRLLQAFTLLPS 425
C GE LAR+ELF+ T ++Q F L S
Sbjct: 388 CFGEGLARMELFLFFTTVMQNFRLKSS 414
>gi|16933533 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 2 [Homo sapiens]
Length = 503
Score = 108 bits (270), Expect = 1e-23
Identities = 95/372 (25%), Positives = 164/372 (44%), Gaps = 36/372 (9%)
Query: 87 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTPVAIEEEFSLLTCSIIC 144
WK + L A M P++ Q +R A+ + +++ F T +I
Sbjct: 126 WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVIT 185
Query: 145 YLTFGDKIKD-DNLMPAYYKCIQEVLKT-WSHWSIQIVDVIPFLRFFPNPGLRRLKQAIE 202
FG + +N + K ++++LK + + ++ + PFL P L +
Sbjct: 186 GTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFL----TPVFEALNIGLF 241
Query: 203 KRD--HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLL 260
+D H ++ + + KES + + + +D+ Q + + +E + + A ++
Sbjct: 242 PKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSII 301
Query: 261 I--GGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 318
I +TT+ TL + + L HP++QQ+LQEE+D L + + V Y ++ L+
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL---PNKAPVTYDALVQMEYLDM 358
Query: 319 TIAEVLRLRPVVPLALPHRTTRPSS----ISGYDIPEGTVIIPNLQGAHLDETVWERPHE 374
+ E LRL PVV R TR I+G IP+G ++ + H D W P +
Sbjct: 359 VVNETLRLFPVVS-----RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEK 413
Query: 375 FWPDRFLEPGKNS----RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSG---- 426
F P+RF + K+S R + FG G R C+G A + + + R LQ F+ P
Sbjct: 414 FCPERFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQI 473
Query: 427 ----DALPSLQP 434
D LP LQP
Sbjct: 474 PLKLDNLPILQP 485
>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
isoform 2 [Homo sapiens]
Length = 431
Score = 107 bits (268), Expect = 2e-23
Identities = 66/198 (33%), Positives = 104/198 (52%), Gaps = 10/198 (5%)
Query: 232 LQGVAQPSMEEGSGQLLEGHVHM---AAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRL 288
L+ ++ P ++E Q E V D+ GTETT+ TL + ++ LL +PE+ ++
Sbjct: 205 LRILSSPWIQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKV 264
Query: 289 QEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYD 348
QEE++ +G S +DR+ +P +A + E+ R ++P LPH T Y
Sbjct: 265 QEEIECVVGRNRSPCM---QDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYL 321
Query: 349 IPEGTVIIPNLQGAHLDETVWERPHEFWPDRFLEPGKNSRA----LAFGCGARVCLGEPL 404
IP+GT II +L ++ + P F P FL+ N + + F G R+C+GE L
Sbjct: 322 IPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGL 381
Query: 405 ARLELFVVLTRLLQAFTL 422
AR+ELF+ LT +LQ F L
Sbjct: 382 ARMELFLFLTTILQNFNL 399
>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
[Homo sapiens]
Length = 503
Score = 103 bits (258), Expect = 3e-22
Identities = 92/350 (26%), Positives = 161/350 (46%), Gaps = 20/350 (5%)
Query: 87 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTPVAIEEEFSLLTCSIIC 144
WK + L G M P++ Q +R A+ G PV +++ F + +I
Sbjct: 126 WKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVIT 185
Query: 145 YLTFGDKIKD-DNLMPAYYKCIQEVLK-TWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIE 202
+FG I +N + + +++L+ + + V PFL P L L +
Sbjct: 186 STSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLI----PILEVLNICVF 241
Query: 203 KRD--HIVEMQLRQHKESLVAGQWRDMMDYM-LQGVAQPSMEEGSGQLLEGHVHMA-AVD 258
R+ + + +++ KES + + +D++ L +Q S E S + L +A ++
Sbjct: 242 PREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSII 301
Query: 259 LLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 318
+ G ETT++ LS+ + L HP++QQ+LQEE+D L A + Y ++ L+
Sbjct: 302 FIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPT---YDTVLQMEYLDM 358
Query: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378
+ E LRL P+ + L + I+G IP+G V++ H D W P +F P+
Sbjct: 359 VVNETLRLFPIA-MRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPE 417
Query: 379 RFLEPGKNS----RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP 424
RF + K++ FG G R C+G A + + + L R+LQ F+ P
Sbjct: 418 RFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKP 467
>gi|12383060 cytochrome P450, family 3, subfamily A, polypeptide 43
isoform 1 [Homo sapiens]
Length = 504
Score = 103 bits (258), Expect = 3e-22
Identities = 92/369 (24%), Positives = 163/369 (44%), Gaps = 29/369 (7%)
Query: 87 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTPVAIEEEFSLLTCSIIC 144
WK + L A M P++ Q +R A+ + +++ F T +I
Sbjct: 126 WKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQEAENSKSINLKDFFGAYTMDVIT 185
Query: 145 YLTFGDKIKD-DNLMPAYYKCIQEVLKT-WSHWSIQIVDVIPFLRFFPNPGLRRLKQAIE 202
FG + +N + K ++++LK + + ++ + PFL P L +
Sbjct: 186 GTLFGVNLDSLNNPQDPFLKNMKKLLKLDFLDPFLLLISLFPFL----TPVFEALNIGLF 241
Query: 203 KRD--HIVEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLL 260
+D H ++ + + KES + + + +D+ Q + + +E + + A ++
Sbjct: 242 PKDVTHFLKNSIERMKESRLKDKQKHRVDFFQQMIDSQNSKETKSHKALSDLELVAQSII 301
Query: 261 I--GGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNA 318
I +TT+ TL + + L HP++QQ+LQEE+D L + + V Y ++ L+
Sbjct: 302 IIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL---PNKAPVTYDALVQMEYLDM 358
Query: 319 TIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPD 378
+ E LRL PVV + + I+G IP+G ++ + H D W P +F P+
Sbjct: 359 VVNETLRLFPVVS-RVTRVCKKDIEINGVFIPKGLAVMVPIYALHHDPKYWTEPEKFCPE 417
Query: 379 -RFLEPGKNS----RALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSG------- 426
RF + K+S R + FG G R C+G A + + + R LQ F+ P
Sbjct: 418 SRFSKKNKDSIDLYRYIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPLK 477
Query: 427 -DALPSLQP 434
D LP LQP
Sbjct: 478 LDNLPILQP 486
>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
[Homo sapiens]
Length = 502
Score = 102 bits (253), Expect = 1e-21
Identities = 86/348 (24%), Positives = 156/348 (44%), Gaps = 17/348 (4%)
Query: 87 WKAHKKLTRSALLLGIRDSMEPVVEQLTQEFCERMR--AQPGTPVAIEEEFSLLTCSIIC 144
WK + L G M P++ Q +R A+ G PV +++ F + +I
Sbjct: 126 WKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYSMDVIT 185
Query: 145 YLTFGDKIKD-DNLMPAYYKCIQEVLKTWSHWSIQIVDVIPFLRFFPNPGLRRLKQAIEK 203
+FG I +N + + ++ LK + + +I F F P L ++
Sbjct: 186 GTSFGVNIDSLNNPQDPFVESTKKFLK-FGFLDPLFLSIILFP--FLTPVFEALNVSLFP 242
Query: 204 RDHI--VEMQLRQHKESLVAGQWRDMMDYMLQGVAQPSMEEGSGQLLEGHVHMAAVDLLI 261
+D I + + + K+S + + + +D++ + + +E + +AA ++
Sbjct: 243 KDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSIIF 302
Query: 262 --GGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNAT 319
G ETT++ LS+ + L HP++QQ+LQ+E+D L A + Y ++ L+
Sbjct: 303 IFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPT---YDAVVQMEYLDMV 359
Query: 320 IAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQGAHLDETVWERPHEFWPDR 379
+ E LRL PV + L + I+G IP+G++++ H D W P EF P+R
Sbjct: 360 VNETLRLFPVA-IRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418
Query: 380 FLEPGKNSRA---LAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLP 424
F + + FG G R C+G A + + + L R+LQ F+ P
Sbjct: 419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKP 466
>gi|4503213 cytochrome P450, family 27, subfamily B, polypeptide 1
[Homo sapiens]
Length = 508
Score = 102 bits (253), Expect = 1e-21
Identities = 70/193 (36%), Positives = 97/193 (50%), Gaps = 9/193 (4%)
Query: 241 EEGSGQLLEGHVHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGA 300
EE Q + G+V +LL+ G +T +NTLSWA+ L HPE+Q L E+ L PG
Sbjct: 300 EELPAQSILGNV----TELLLAGVDTVSNTLSWALYELSRHPEVQTALHSEITAALSPG- 354
Query: 301 SSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPNLQ 360
SS+ ++LPLL A + EVLRL PVVP + + Y IP+ T++
Sbjct: 355 SSAYPSATVLSQLPLLKAVVKEVLRLYPVVP-GNSRVPDKDIHVGDYIIPKNTLVTLCHY 413
Query: 361 GAHLDETVWERPHEFWPDRFLEPGKNSR---ALAFGCGARVCLGEPLARLELFVVLTRLL 417
D + P+ F P R+L G +L FG G R C+G LA LEL + L ++L
Sbjct: 414 ATSRDPAQFPEPNSFRPARWLGEGPTPHPFASLPFGFGKRSCMGRRLAELELQMALAQIL 473
Query: 418 QAFTLLPSGDALP 430
F + P A P
Sbjct: 474 THFEVQPEPGAAP 486
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.439
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,597,655
Number of Sequences: 37866
Number of extensions: 929974
Number of successful extensions: 2400
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2157
Number of HSP's gapped (non-prelim): 93
length of query: 465
length of database: 18,247,518
effective HSP length: 106
effective length of query: 359
effective length of database: 14,233,722
effective search space: 5109906198
effective search space used: 5109906198
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.