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Search of human proteins with 190358524
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190358524 follistatin-like 5 isoform c [Homo sapiens]
(837 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190358524 follistatin-like 5 isoform c [Homo sapiens] 1716 0.0
gi|190358522 follistatin-like 5 isoform b [Homo sapiens] 1705 0.0
gi|190358520 follistatin-like 5 isoform a [Homo sapiens] 1701 0.0
gi|54792136 follistatin-like 4 [Homo sapiens] 964 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 96 2e-19
gi|5901956 follistatin-like 1 precursor [Homo sapiens] 89 1e-17
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 86 1e-16
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 83 9e-16
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 83 9e-16
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 83 9e-16
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 79 2e-14
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 77 9e-14
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 76 1e-13
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 75 2e-13
gi|119220552 sidekick 1 [Homo sapiens] 75 3e-13
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 75 3e-13
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 75 3e-13
gi|83281200 protogenin [Homo sapiens] 74 4e-13
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 73 1e-12
gi|109150416 peroxidasin [Homo sapiens] 72 2e-12
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 72 3e-12
gi|224994173 roundabout 1 isoform d [Homo sapiens] 71 4e-12
gi|224994171 roundabout 1 isoform c [Homo sapiens] 71 4e-12
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 71 4e-12
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 71 4e-12
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 71 4e-12
gi|19743806 roundabout 1 isoform b [Homo sapiens] 70 6e-12
gi|4506569 roundabout 1 isoform a [Homo sapiens] 70 6e-12
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 70 6e-12
gi|110349719 titin isoform N2-A [Homo sapiens] 70 8e-12
>gi|190358524 follistatin-like 5 isoform c [Homo sapiens]
Length = 837
Score = 1716 bits (4443), Expect = 0.0
Identities = 837/837 (100%), Positives = 837/837 (100%)
Query: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKEKNQESSRVKGFMIQDGP 60
MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKEKNQESSRVKGFMIQDGP
Sbjct: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKEKNQESSRVKGFMIQDGP 60
Query: 61 FGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLK 120
FGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLK
Sbjct: 61 FGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLK 120
Query: 121 KQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLVD 180
KQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLVD
Sbjct: 121 KQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLVD 180
Query: 181 QMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRA 240
QMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRA
Sbjct: 181 QMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRA 240
Query: 241 FQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG 300
FQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG
Sbjct: 241 FQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG 300
Query: 301 DDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLR 360
DDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLR
Sbjct: 301 DDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLR 360
Query: 361 CHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 420
CHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV
Sbjct: 361 CHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 420
Query: 421 DEDISSLFVEDSARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVC 480
DEDISSLFVEDSARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVC
Sbjct: 421 DEDISSLFVEDSARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVC 480
Query: 481 PKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVPVKLHYD 540
PKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVPVKLHYD
Sbjct: 481 PKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVPVKLHYD 540
Query: 541 KSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTTTLII 600
KSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTTTLII
Sbjct: 541 KSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDFFIPTTTLII 600
Query: 601 THMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGYYFIGCKPDST 660
THMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGYYFIGCKPDST
Sbjct: 601 THMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGYYFIGCKPDST 660
Query: 661 GAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQYITIRGEIQEA 720
GAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQYITIRGEIQEA
Sbjct: 661 GAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQYITIRGEIQEA 720
Query: 721 FDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIKSLKEPLKAEE 780
FDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIKSLKEPLKAEE
Sbjct: 721 FDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIKSLKEPLKAEE 780
Query: 781 WPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNTVIWVGDA 837
WPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNTVIWVGDA
Sbjct: 781 WPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNTVIWVGDA 837
>gi|190358522 follistatin-like 5 isoform b [Homo sapiens]
Length = 846
Score = 1705 bits (4416), Expect = 0.0
Identities = 836/846 (98%), Positives = 836/846 (98%), Gaps = 9/846 (1%)
Query: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKEKNQESSRVKGFMIQDGP 60
MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKEKNQESSRVKGFMIQDGP
Sbjct: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKEKNQESSRVKGFMIQDGP 60
Query: 61 FGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLK 120
FGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLK
Sbjct: 61 FGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLK 120
Query: 121 KQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLVD 180
KQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLVD
Sbjct: 121 KQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLVD 180
Query: 181 QMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRA 240
QMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRA
Sbjct: 181 QMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRA 240
Query: 241 FQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG 300
FQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG
Sbjct: 241 FQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG 300
Query: 301 DDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLR 360
DDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLR
Sbjct: 301 DDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLR 360
Query: 361 CHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 420
CHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV
Sbjct: 361 CHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 420
Query: 421 DEDISSLFVEDSARKT---------RLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEK 471
DEDISSLFVEDSARKT LGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEK
Sbjct: 421 DEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEK 480
Query: 472 LLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTD 531
LLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTD
Sbjct: 481 LLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTD 540
Query: 532 PVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDF 591
PVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDF
Sbjct: 541 PVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDDF 600
Query: 592 FIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGYY 651
FIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGYY
Sbjct: 601 FIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGYY 660
Query: 652 FIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQYI 711
FIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQYI
Sbjct: 661 FIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQYI 720
Query: 712 TIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIKS 771
TIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIKS
Sbjct: 721 TIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIKS 780
Query: 772 LKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNTV 831
LKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNTV
Sbjct: 781 LKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNTV 840
Query: 832 IWVGDA 837
IWVGDA
Sbjct: 841 IWVGDA 846
>gi|190358520 follistatin-like 5 isoform a [Homo sapiens]
Length = 847
Score = 1701 bits (4404), Expect = 0.0
Identities = 836/847 (98%), Positives = 836/847 (98%), Gaps = 10/847 (1%)
Query: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHK-EKNQESSRVKGFMIQDG 59
MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHK EKNQESSRVKGFMIQDG
Sbjct: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKQEKNQESSRVKGFMIQDG 60
Query: 60 PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL 119
PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL
Sbjct: 61 PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL 120
Query: 120 KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV 179
KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV
Sbjct: 121 KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV 180
Query: 180 DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR 239
DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR
Sbjct: 181 DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR 240
Query: 240 AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 299
AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF
Sbjct: 241 AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 300
Query: 300 GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 359
GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL
Sbjct: 301 GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 360
Query: 360 RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG
Sbjct: 361 RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
Query: 420 VDEDISSLFVEDSARKTR---------LGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE 470
VDEDISSLFVEDSARKT LGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE
Sbjct: 421 VDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE 480
Query: 471 KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST 530
KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST
Sbjct: 481 KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST 540
Query: 531 DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD 590
DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD
Sbjct: 541 DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD 600
Query: 591 FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY 650
FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY
Sbjct: 601 FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY 660
Query: 651 YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY 710
YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY
Sbjct: 661 YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY 720
Query: 711 ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK 770
ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK
Sbjct: 721 ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK 780
Query: 771 SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT 830
SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT
Sbjct: 781 SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT 840
Query: 831 VIWVGDA 837
VIWVGDA
Sbjct: 841 VIWVGDA 847
>gi|54792136 follistatin-like 4 [Homo sapiens]
Length = 842
Score = 964 bits (2493), Expect = 0.0
Identities = 460/800 (57%), Positives = 603/800 (75%), Gaps = 16/800 (2%)
Query: 47 ESSRVKGFMIQDGPFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEF 106
E +R +G + SC K+C G CV SR+TG+ EC C++ C+ Y PVCGSDG F
Sbjct: 48 EVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVCGSDGRF 107
Query: 107 YENHCEVHRAACLKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENEN 166
YENHC++HRAACL ++IT++H++DCF KGD C Y+++KN+LL LQ + +QE ++
Sbjct: 108 YENHCKLHRAACLLGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQPLQEGDS 167
Query: 167 PNGDDISRKKLLVDQMFKYFDADSNGLVDINELTQ-VIKQEELGKDLFDCTLYVLLKYDD 225
D S+K+LLV+ +F+ DAD NG + +EL Q V+K+++L +DL C+ LL++DD
Sbjct: 168 RQ-DPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGDLLRFDD 226
Query: 226 FNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNN 285
+N+D L L EFY AFQV+QLSL + ++S+T TVG S VL+CA+ G LRPPIIWKRN
Sbjct: 227 YNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPIIWKRNG 286
Query: 286 IILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVY 345
+ LN LDLEDINDFG+D SLYITKVTT H+GNYTC+A G+EQ++QTH+ QVNVPPVIRVY
Sbjct: 287 LTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVPPVIRVY 346
Query: 346 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYE 405
PESQA+EPGV ASLRCHAEGIP P++ WLKNG+D++ ++SKQL+L ANGSE+HIS+VRYE
Sbjct: 347 PESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHISSVRYE 406
Query: 406 DTGAYTCIAKNEAGVDEDISSLFVEDSARKT---------RLGIGNMFYVFYEDGIKVIQ 456
DTGAYTCIAKNE GVDEDISSLF+EDSARKT L +GNMFYVF +DGI VI
Sbjct: 407 DTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDDGIIVIH 466
Query: 457 PIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLI 516
P++CE QRH+KP+EK+ +E+CP+ E + Q C W SAVNV++++IYVAQP L RVL+
Sbjct: 467 PVDCEIQRHLKPTEKIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPALSRVLV 526
Query: 517 VDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTI 576
VD+Q+QKV+Q++ DP+P KL YDKSHDQVWVLSWG + K+ P+LQVIT AS H I
Sbjct: 527 VDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTGQSQHLI 586
Query: 577 HTQPVGKQFDRVDDFFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYK 636
T F VDDFFIP T LII H+RFGFI +K + A+ K+DLETM +KTI L +
Sbjct: 587 RT-----PFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTIGLHHHG 641
Query: 637 CVPQSLAYTHLGGYYFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYL 696
CVPQ++A+THLGGY+FI C+ DS + + Q++VD VTDSV+G N DVTGTP+ SPDG ++
Sbjct: 642 CVPQAMAHTHLGGYFFIQCRQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTSPDGRFI 701
Query: 697 VSINDVKGLVRVQYITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDV 756
VS + VQ IT+RGEIQ +D+ N ISDLAFQ SFTE++QYNIY + T+ D+
Sbjct: 702 VSAAADSPWLHVQEITVRGEIQTLYDLQINSGISDLAFQRSFTESNQYNIYAALHTEPDL 761
Query: 757 LFVELSSGKVKMIKSLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLN 816
LF+ELS+GKV M+K+LKEP PW +R ++DSGLFGQYL+TP+++SLF+++GR N
Sbjct: 762 LFLELSTGKVGMLKNLKEPPAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFLINGRQN 821
Query: 817 KLNCEITEVEKGNTVIWVGD 836
L CE++ ++ G TV+WVG+
Sbjct: 822 TLRCEVSGIKGGTTVVWVGE 841
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 95.5 bits (236), Expect = 2e-19
Identities = 57/183 (31%), Positives = 86/183 (46%), Gaps = 3/183 (1%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
E + + T+ L+C G P I W +N+ + N D ++ L I +
Sbjct: 3154 EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIAR 3213
Query: 310 VTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIR--VYPESQAREPGVTASLRCHAEGI 366
+ GNYTC A E Q + F + VPP + P + G L C+A GI
Sbjct: 3214 SQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGI 3273
Query: 367 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISS 426
P P + WLK+G I ++++ + ANGS ++I DTG YTC+A N AG ++ I +
Sbjct: 3274 PTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFN 3333
Query: 427 LFV 429
L V
Sbjct: 3334 LNV 3336
Score = 75.5 bits (184), Expect = 2e-13
Identities = 56/171 (32%), Positives = 79/171 (46%), Gaps = 9/171 (5%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G+ LSC G P + W NN I+ + +N + L I +V+ G Y C
Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFNNNIIP-AHFDSVNGHSE---LVIERVSKEDSGTYVCT 4329
Query: 322 ADGYEQVYQTHIF-QVNVPPVIRV-YPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 379
A+ + F V PPV + YP + G A L C +G P P + W + G+D
Sbjct: 4330 AENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVD 4389
Query: 380 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
I ++S ++ NGS V ED G YTC+A NEAGV E SL ++
Sbjct: 4390 I--EISHRIRQLGNGSLAIYGTVN-EDAGDYTCVATNEAGVVERSMSLTLQ 4437
Score = 74.7 bits (182), Expect = 3e-13
Identities = 54/172 (31%), Positives = 76/172 (44%), Gaps = 5/172 (2%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
+ +S VL C +G P I W+++ +L ++G L+I T G Y C
Sbjct: 3726 LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHAR--YSILENGFLHIQSAHVTDTGRYLC 3783
Query: 321 YADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG-I 378
A + I QV+VPP I P + V +L C A GIPKP + W KNG +
Sbjct: 3784 MATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHL 3843
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ L ++GS V IS +DT Y C N AG D+ L V+
Sbjct: 3844 LNVDQNQNSYRLLSSGSLVIIS-PSVDDTATYECTVTNGAGDDKRTVDLTVQ 3894
Score = 73.6 bits (179), Expect = 7e-13
Identities = 51/168 (30%), Positives = 76/168 (45%), Gaps = 9/168 (5%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
VGQ + C QGT P I W + + +++ DG+L I + T + G YTC
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN--PDGTLSIDQATPSDAGIYTC 1241
Query: 321 YADGYEQVYQTHI-FQVNVPPVIRVYPES-----QAREPGVTASLRCHAEGIPKPQLGWL 374
A +T I V PP + Q R C A+G PKP + WL
Sbjct: 1242 VATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWL 1301
Query: 375 KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
NG ++T + +++ +G+ + I++V D G Y C+A NEAG E
Sbjct: 1302 HNGRELTGR-EPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTE 1348
Score = 73.2 bits (178), Expect = 1e-12
Identities = 52/188 (27%), Positives = 83/188 (44%), Gaps = 6/188 (3%)
Query: 245 QLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS 304
Q L +D+ + I+ G+ L C ++ P I W + +++ + F GS
Sbjct: 1078 QRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITWAKETQLISPFSPR--HTFLPSGS 1134
Query: 305 LYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHA 363
+ IT+ T+ G Y C A V Q V+VPP I+ P+ + G + C+A
Sbjct: 1135 MKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNA 1194
Query: 364 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDED 423
+G P P + W K G T + + + + I D G YTC+A N AG DE
Sbjct: 1195 QGTPLPVITWSKGG--STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDET 1252
Query: 424 ISSLFVED 431
+L V++
Sbjct: 1253 EITLHVQE 1260
Score = 72.8 bits (177), Expect = 1e-12
Identities = 49/169 (28%), Positives = 76/169 (44%), Gaps = 5/169 (2%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
T G+ AVL+C I + + W+RN+ + + I + SL + V G Y
Sbjct: 532 TPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANL-SLELKSVKFNDAGEYH 590
Query: 320 CYADGYEQVYQTHIF-QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
C +F V PP + V P++Q+ G S+ C A G PKP++ W N +
Sbjct: 591 CMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDM 650
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSL 427
I ++T + + I N +D G Y C+A N AG D+ S+L
Sbjct: 651 FIVGSHRYRMT---SDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696
Score = 72.8 bits (177), Expect = 1e-12
Identities = 58/171 (33%), Positives = 76/171 (44%), Gaps = 8/171 (4%)
Query: 261 VGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
V + LSC G P I W K I+ ++ ++ GSL I V G+YT
Sbjct: 4092 VDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSS----GSLQIAFVQPGDAGHYT 4147
Query: 320 CYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
C A T V+VPP IR A L C A+GIP P + W K+ +
Sbjct: 4148 CMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNV 4207
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
+ L K T + G E+ + NV ED+G YTC+A N AG D SL V
Sbjct: 4208 LLANLLGKY-TAEPYG-ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 71.6 bits (174), Expect = 3e-12
Identities = 50/174 (28%), Positives = 78/174 (44%), Gaps = 8/174 (4%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
T G+S L C +QG P + W ++ L +I D G L + + + G Y
Sbjct: 2305 TRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQLKNIHVSDTGRYV 2362
Query: 320 CYADGYEQVY-QTHIFQVNVPPVI---RVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 375
C A + + + V+ PP I PE+ + + SL C A GIP P + W K
Sbjct: 2363 CVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFK 2422
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
+G ++ LS + + + G + + ED G YTC+ +N AG + I L V
Sbjct: 2423 DGWPVS--LSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSV 2474
Score = 70.9 bits (172), Expect = 5e-12
Identities = 46/160 (28%), Positives = 68/160 (42%), Gaps = 3/160 (1%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
V L+C G +P I W++N +LN ++ GSL I + Y C
Sbjct: 3817 VNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYEC 3876
Query: 321 -YADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 379
+G +T V VPP I P A + C A G+P P + W KNGI
Sbjct: 3877 TVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIR 3936
Query: 380 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ P+ L + E+ + + + G YTC+A+N AG
Sbjct: 3937 LLPRGDGYRILSSGAIEILATQLNH--AGRYTCVARNAAG 3974
Score = 70.9 bits (172), Expect = 5e-12
Identities = 53/171 (30%), Positives = 75/171 (43%), Gaps = 13/171 (7%)
Query: 265 AVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD--GSLYITKVTTTHVGNYTCYA 322
A+L C G P I WK++N++L NL + + + G L + V G YTC A
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANL----LGKYTAEPYGELILENVVLEDSGFYTCVA 4241
Query: 323 DGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDIT 381
+ + T V+V P P + G L C A GIP P+L W N I
Sbjct: 4242 NNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIP 4301
Query: 382 PKLSKQLTLQANG-SEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
NG SE+ I V ED+G Y C A+N G + I ++V++
Sbjct: 4302 AHFDS-----VNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKE 4347
Score = 70.1 bits (170), Expect = 8e-12
Identities = 54/165 (32%), Positives = 74/165 (44%), Gaps = 9/165 (5%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LYITKVTTTHVGNYTC 320
G S ++C GT P + W R+ L L+ G L + K T G YTC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDG---QPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTC 3506
Query: 321 YADGYEQVYQTH-IFQVNVPPVIRVYPESQAREPGVT--ASLRCHAEGIPKPQLGWLKNG 377
A H I +V PP I E + V L C A GIP P++ W+K+G
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDG 3566
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ P+ + TL G + IS + EDTG YTC+A + AG D+
Sbjct: 3567 RPL-PQTDQVQTL-GGGEVLRISTAQVEDTGRYTCLASSPAGDDD 3609
Score = 69.3 bits (168), Expect = 1e-11
Identities = 57/186 (30%), Positives = 83/186 (44%), Gaps = 15/186 (8%)
Query: 248 LPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LY 306
LPE+ V +SA++ C G+ P W+++ L +D + F +G L
Sbjct: 2878 LPEE-----VTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLE---DDHHKFLSNGRILQ 2929
Query: 307 ITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVT--ASLRCHA 363
I T +G Y C A+ + + V+VPP + + P+S+ V SL C
Sbjct: 2930 ILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSV-IGPKSENLTVVVNNFISLTCEV 2988
Query: 364 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDED 423
G P P L WLKN I KL+ + G + I + D G YTCIA N+AG +
Sbjct: 2989 SGFPPPDLSWLKNEQPI--KLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 424 ISSLFV 429
SL V
Sbjct: 3047 KFSLTV 3052
Score = 68.9 bits (167), Expect = 2e-11
Identities = 51/160 (31%), Positives = 68/160 (42%), Gaps = 5/160 (3%)
Query: 263 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA 322
+ L C P I W RN L I G L I NYTC A
Sbjct: 3637 RQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGR--YLQINNADLGDTANYTCVA 3694
Query: 323 DGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDIT 381
+ + I VNVPP I+ P+S + L C AEG+P P++ W K+G +
Sbjct: 3695 SNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA 3754
Query: 382 PKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
++ L+ NG +HI + DTG Y C+A N AG D
Sbjct: 3755 GNHARYSILE-NGF-LHIQSAHVTDTGRYLCMATNAAGTD 3792
Score = 68.9 bits (167), Expect = 2e-11
Identities = 47/163 (28%), Positives = 78/163 (47%), Gaps = 13/163 (7%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLE---DINDFGDDGSLYITKVTTTHVGN 317
+G +A+L+C ++G P I W R + D+E I G+ GSL I G+
Sbjct: 4363 LGGNAILNCEVKGDPTPTIQWNRKGV-----DIEISHRIRQLGN-GSLAIYGTVNEDAGD 4416
Query: 318 YTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKN 376
YTC A V + + + PP+I + P G L C A G P+P + W +
Sbjct: 4417 YTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQ 4476
Query: 377 GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
G I+ ++ + +N S ++I++ + EDT + C+A+N G
Sbjct: 4477 GHSIS--WDDRVNVLSNNS-LYIADAQKEDTSEFECVARNLMG 4516
Score = 66.2 bits (160), Expect = 1e-10
Identities = 51/176 (28%), Positives = 82/176 (46%), Gaps = 11/176 (6%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNN---IILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
+G + L C +QG P I W+R + I + I+ G+L+I + + G
Sbjct: 806 IGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRT-GALFILNLWASDKGT 864
Query: 318 YTCYAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHA-EGIPKPQLGW 373
Y C A+ G Q T V P+I + P G +L C G P P+ W
Sbjct: 865 YICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRW 924
Query: 374 LKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
+KN + + +T++++GS +HI V+ +D G YTC+A N AG + +S+ V
Sbjct: 925 IKNSAMLLQ--NPYITVRSDGS-LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVV 977
Score = 66.2 bits (160), Expect = 1e-10
Identities = 51/172 (29%), Positives = 74/172 (43%), Gaps = 10/172 (5%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
V S + C GT P I W +N + L I + I + + V YTC
Sbjct: 3356 VDTSINIECRATGTPPPQINWLKNGLPLPLSS--HIRLLAAGQVIRIVRAQVSDVAVYTC 3413
Query: 321 YADGYEQVYQTHI-FQVNVPPVI--RVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 377
A V H QV PP + + E G + S+ C +G P P + WL++G
Sbjct: 3414 VASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDG 3473
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
+ L LT+ +G + + ED+G YTCIA NEAG ++S F+
Sbjct: 3474 QPLG--LDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAG---EVSKHFI 3520
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/169 (27%), Positives = 73/169 (43%), Gaps = 4/169 (2%)
Query: 255 SITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH 314
++ A V L C +G P + W ++ +++ + L +T +
Sbjct: 2019 NMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFS-NGLQVLSGGRILALTSAQISD 2077
Query: 315 VGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 373
G YTC A Q I +V VPP I ++ + L C ++ IP P L W
Sbjct: 2078 TGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTW 2137
Query: 374 LKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
LK+G + K L++ N S + I + + +DTG YTC A N AG E
Sbjct: 2138 LKDGHPLLKKPG--LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTE 2184
Score = 65.5 bits (158), Expect = 2e-10
Identities = 52/181 (28%), Positives = 76/181 (41%), Gaps = 16/181 (8%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLY 306
P+ + L++ V L+C + G P + W +N I LN L +L
Sbjct: 2969 PKSENLTVV---VNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLI----VPGGRTLQ 3021
Query: 307 ITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAR----EPGVTASLRC 361
I + + G YTC A + + V VPP I+ + G + SL C
Sbjct: 3022 IIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLEC 3081
Query: 362 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
+ +P P + W KNG IT S + + A+G +HI DTG Y C A N AG D
Sbjct: 3082 ESNAVPPPVITWYKNGRMITE--STHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRD 3139
Query: 422 E 422
+
Sbjct: 3140 D 3140
Score = 64.3 bits (155), Expect = 4e-10
Identities = 49/170 (28%), Positives = 77/170 (45%), Gaps = 11/170 (6%)
Query: 267 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYE 326
L C + G+ P I+W ++ +++ D I G L I + ++ G Y C A
Sbjct: 1754 LDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGR--KLVIAQAQVSNTGLYRCMAANTA 1811
Query: 327 QVYQTHI-FQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLGWLKNGIDIT 381
++ V+VPP I+ S E V +L+C A GIP P + WLK+ +
Sbjct: 1812 GDHKKEFEVTVHVPPTIK---SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVN 1868
Query: 382 PKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
L +Q++G + I+ ED G YTC+A N AG + L V +
Sbjct: 1869 TAQGN-LKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHE 1917
Score = 64.3 bits (155), Expect = 4e-10
Identities = 46/164 (28%), Positives = 72/164 (43%), Gaps = 12/164 (7%)
Query: 263 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA 322
QS L+C + G P I W ++ L + I G L IT V H G YTC A
Sbjct: 2495 QSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGR--FLQITNVQVPHTGRYTCLA 2552
Query: 323 DGYEQVYQTHIFQVNV---PPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLGWLK 375
+++ F +NV P + V + + V SL C A P + W K
Sbjct: 2553 SS-PAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFK 2611
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+G + + ++ + + G + I N + ++ G Y+C+A NEAG
Sbjct: 2612 DGTPL--ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653
Score = 63.9 bits (154), Expect = 6e-10
Identities = 51/176 (28%), Positives = 73/176 (41%), Gaps = 8/176 (4%)
Query: 247 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 306
SL + K+ V L C G P I W ++N +L+ + G +
Sbjct: 1920 SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQ--IID 1977
Query: 307 ITKVTTTHVGNYTCYADGYEQVYQTHIF---QVNVPPVIRVYPESQAREPGVTASLRCHA 363
I + G Y C A T +F QV+V P I A L C A
Sbjct: 1978 IESAQISDAGIYKCVA--INSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEA 2035
Query: 364 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
GIP P L WLK+G ++ S L + + G + +++ + DTG YTC+A N AG
Sbjct: 2036 RGIPAPSLTWLKDGSPVS-SFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAG 2090
Score = 63.5 bits (153), Expect = 8e-10
Identities = 43/175 (24%), Positives = 74/175 (42%), Gaps = 6/175 (3%)
Query: 248 LPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYI 307
+ + ++++ + + Q L C ++GT P I+W ++N+ + + I + L +
Sbjct: 1361 IKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT--ESSTIQTVNNGKILKL 1418
Query: 308 TKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVI--RVYPESQAREPGVTASLRCHAE 364
+ T G Y+C A Q + V VPP I +P + +L C +
Sbjct: 1419 FRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVK 1478
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
G P P + W K+G + + L G +H+ N R D G Y C N AG
Sbjct: 1479 GTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAG 1532
Score = 63.5 bits (153), Expect = 8e-10
Identities = 46/165 (27%), Positives = 70/165 (42%), Gaps = 6/165 (3%)
Query: 266 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY 325
+L C GT P I W++ I +N + G L I++ G Y C A
Sbjct: 4006 LLPCEATGTPSPFITWQKEGINVNTSGRN--HAVLPSGGLQISRAVREDAGTYMCVAQNP 4063
Query: 326 EQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKL 384
I V VPPVI + + +L C A+G+P P + W K+G I +
Sbjct: 4064 AGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESI 4123
Query: 385 SKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
+++ + + I+ V+ D G YTC+A N AG + L V
Sbjct: 4124 RQRV---LSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/167 (29%), Positives = 76/167 (45%), Gaps = 7/167 (4%)
Query: 255 SITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 313
S+ GQ L C + G P W +N+ +L + DGSL+I +V
Sbjct: 897 SVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS---DGSLHIERVQLQ 953
Query: 314 HVGNYTCYADGYEQVY-QTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLG 372
G YTC A +T V+V P I+ + + G+ +L C A G PKP +
Sbjct: 954 DGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI 1013
Query: 373 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
W K G ++ S + + A+GS +++ + E++G Y C A N AG
Sbjct: 1014 WSKKG-ELISTSSAKFSAGADGS-LYVVSPGGEESGEYVCTATNTAG 1058
Score = 62.0 bits (149), Expect = 2e-09
Identities = 38/128 (29%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Query: 304 SLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIR--------VYPESQAREPG 354
+L I + G Y+C A ++ + + +V +PP+I + P+ +
Sbjct: 2630 TLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVN 2689
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
T +L C A IP L W K+G + K + + ANG + I + DTG YTC+A
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPL--KSDDHVNIAANGHTLQIKEAQISDTGRYTCVA 2747
Query: 415 KNEAGVDE 422
N AG DE
Sbjct: 2748 SNIAGEDE 2755
Score = 59.3 bits (142), Expect = 1e-08
Identities = 47/159 (29%), Positives = 68/159 (42%), Gaps = 10/159 (6%)
Query: 269 CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGYEQ 327
C +GT +P I W N L + I+ D L I VT G Y C A +
Sbjct: 1288 CPAKGTPKPTIKWLHNGRELTGRE-PGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT 1346
Query: 328 VYQTHIFQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLGWLKNGIDITPK 383
+ + +V+VPPVI+ + Q V +L C EG P P + W K+ + +T
Sbjct: 1347 TERKYNLKVHVPPVIK--DKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTE- 1403
Query: 384 LSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
S + NG + + ED G Y+C A N AG +
Sbjct: 1404 -SSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQ 1441
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/163 (26%), Positives = 74/163 (45%), Gaps = 14/163 (8%)
Query: 267 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY----A 322
L C +G P I W ++ + + D G L+I + + YTC+ A
Sbjct: 1567 LECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQ--YLHIPRAQVSDSATYTCHVANVA 1624
Query: 323 DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTA---SLRCHAEGIPKPQLGWLKNGID 379
E+ + ++ VPP+I + + V A +L C A G P P L WLK+G+
Sbjct: 1625 GTAEKSFHVDVY---VPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVP 1681
Query: 380 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ K + + ++A G ++ I + + D G Y C+A + AG E
Sbjct: 1682 V--KANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKE 1722
Score = 57.0 bits (136), Expect = 7e-08
Identities = 55/206 (26%), Positives = 80/206 (38%), Gaps = 12/206 (5%)
Query: 267 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYE 326
L C G P I W +++ +N ++ L I K G YTC A
Sbjct: 1846 LQCIANGIPNPSITWLKDDQPVNTAQ-GNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA 1904
Query: 327 QVYQTHI-FQVNVPPVIRVYPESQAREPGVT--ASLRCHAEGIPKPQLGWLKNGIDITPK 383
Q HI V+ PP + + V+ L C A G P P + W K+ ++
Sbjct: 1905 GETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS 1964
Query: 384 LSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTRLGIGNM 443
S +T G + I + + D G Y C+A N AG E SL V + G NM
Sbjct: 1965 TS--MTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVH--VAPSISGSNNM 2020
Query: 444 FYVFYEDGIKVIQPIECEFQRHIKPS 469
V + ++ +ECE + PS
Sbjct: 2021 VAVVVNNPVR----LECEARGIPAPS 2042
Score = 54.7 bits (130), Expect = 4e-07
Identities = 47/175 (26%), Positives = 71/175 (40%), Gaps = 19/175 (10%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
V + L C + W ++ L + D +N + +L I + + G YTC
Sbjct: 2688 VNNTLTLECEAYAIPSASLSWYKDGQPLKSDD--HVNIAANGHTLQIKEAQISDTGRYTC 2745
Query: 321 YADGYEQVYQTHIFQVN--VPPVIRVYPE----------SQAREPGVT--ASLRCHAEGI 366
A + F VN VPP + E +A++ + SL C
Sbjct: 2746 VASNIAGEDELD-FDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAA 2804
Query: 367 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
P P L W K+G +T S ++ + G + I + ED G YTC+A NEAG D
Sbjct: 2805 PPPTLTWYKDGHPLTS--SDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGED 2857
Score = 53.9 bits (128), Expect = 6e-07
Identities = 47/176 (26%), Positives = 71/176 (40%), Gaps = 14/176 (7%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
E+Q +S+ + Q+ L C P + W ++ L L ++ + L I
Sbjct: 2109 EEQNVSVL---ISQAVELLCQSDAIPPPTLTWLKDGHPL--LKKPGLSISENRSVLKIED 2163
Query: 310 VTTTHVGNYTCYADGY----EQVYQTHIFQVNVPPVIRVYPESQARE--PGVTASLRCHA 363
G YTC A E+ Y +I+ VPP I E G SL C +
Sbjct: 2164 AQVQDTGRYTCEATNVAGKTEKNYNVNIW---VPPNIGGSDELTQLTVIEGNLISLLCES 2220
Query: 364 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
GIP P L W K G + ++ + + G ++ IS D Y+C+A N AG
Sbjct: 2221 SGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAG 2276
Score = 53.5 bits (127), Expect = 8e-07
Identities = 43/164 (26%), Positives = 67/164 (40%), Gaps = 9/164 (5%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
+G V+ C G P + W + ++ L I+ G L I + G+YTC
Sbjct: 715 LGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL--GLLKIQETQDLDAGDYTC 772
Query: 321 YADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 379
A I V PPV P + E G +L C+ +G P+P + W + +D
Sbjct: 773 VAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRR--LD 830
Query: 380 ITPKLSKQLTL----QANGSEVHISNVRYEDTGAYTCIAKNEAG 419
P S+ ++ Q + I N+ D G Y C A+N+ G
Sbjct: 831 NMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874
Score = 52.8 bits (125), Expect = 1e-06
Identities = 56/225 (24%), Positives = 92/225 (40%), Gaps = 21/225 (9%)
Query: 221 LKYDDFNADKHLALEEFYRAFQVIQLSL-PEDQKLSITAATVG---QSAVLSCAIQGTLR 276
LK ++ D +L F R V S+ P+ K+++ T G Q + C++ L
Sbjct: 403 LKVTGYDKDDYL----FQRVSSVSFSSIVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLP 458
Query: 277 PPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-----DGYEQVYQT 331
+ + RN + L ++ +L I KVT + G Y C A G Q +
Sbjct: 459 FTLSFVRNGVTLG---VDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTF-- 513
Query: 332 HIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQ 391
F V+ PP + P + PG A L C L W +N D+ ++
Sbjct: 514 --FDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTL 571
Query: 392 ANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKT 436
AN S + + +V++ D G Y C+ +E G L V++ + T
Sbjct: 572 ANLS-LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVT 615
>gi|5901956 follistatin-like 1 precursor [Homo sapiens]
Length = 308
Score = 89.4 bits (220), Expect = 1e-17
Identities = 57/196 (29%), Positives = 96/196 (48%), Gaps = 26/196 (13%)
Query: 64 CENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQK 123
C N +CG GR C + E G+ C C++ CK H +PVCGS+G+ Y NHCE+HR ACL K
Sbjct: 31 CANVFCGAGRECAVT-EKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSK 89
Query: 124 ITIVHNEDCFFKGD--------KCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRK 175
I + ++ C K C + +++ ++ + I+ + G + S
Sbjct: 90 IQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAE-IIPDGWFSKGSNYSE- 147
Query: 176 KLLVDQMFKYFDADSNGLVDINELTQVIKQ------------EELGKDLFDCTLYVLLKY 223
++D+ FK FD + + +D +E + ++Q +E K L + L++
Sbjct: 148 --ILDKYFKNFD-NGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIEL 204
Query: 224 DDFNADKHLALEEFYR 239
D NAD L+ +EF +
Sbjct: 205 SDENADWKLSFQEFLK 220
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 85.9 bits (211), Expect = 1e-16
Identities = 60/174 (34%), Positives = 84/174 (48%), Gaps = 10/174 (5%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
TV Q+AVL C G RP + W R + + +E I G G+L I+ VT H G Y
Sbjct: 250 TVHQTAVLECVATGNPRPIVSWSR--LDGRPIGVEGIQVLGT-GNLIISDVTVQHSGVYV 306
Query: 320 CYADG----YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 375
C A+ + Q + V P +P+S +R G TA C A+G P P + WLK
Sbjct: 307 CAANRPGTRVRRTAQGRLV-VQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLK 365
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
NG + P + L+ N S + IS + ED Y C+A+N AG + + L V
Sbjct: 366 NGQVLGP--GGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSSQASARLTV 417
Score = 65.9 bits (159), Expect = 2e-10
Identities = 53/195 (27%), Positives = 87/195 (44%), Gaps = 20/195 (10%)
Query: 259 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV------TT 312
A GQ VL C ++GT I W++N + L + +GSL I +
Sbjct: 53 AVPGQPIVLDCRVEGTPPVRITWRKNGV---ELPESTHSTLLANGSLMIRHFRLEPGGSP 109
Query: 313 THVGNYTCYADGYEQVYQTHIFQVNVPPV--IRVYPESQAREPGVTASLRCHAEGIPKPQ 370
+ G+Y C A + + ++ + V+P++ E G A +C G+PKP
Sbjct: 110 SDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL 169
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ W KN + I +++ TL G + I+ +R ED G + C+A N I+S+ +
Sbjct: 170 ITWEKNRVPIDTD-NERYTLLPKG-VLQITGLRAEDGGIFHCVASN-------IASIRIS 220
Query: 431 DSARKTRLGIGNMFY 445
AR T G G+ Y
Sbjct: 221 HGARLTVSGSGSGAY 235
Score = 50.1 bits (118), Expect = 9e-06
Identities = 47/168 (27%), Positives = 73/168 (43%), Gaps = 17/168 (10%)
Query: 259 ATVGQS---AVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHV 315
ATVG+ A C I G +P I W++N + ++ D E G L IT +
Sbjct: 147 ATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDT-DNERYT-LLPKGVLQITGLRAEDG 204
Query: 316 GNYTCYADGYEQVYQTHIFQVNV---------PPVIRVYPESQAREPGVTASLRCHAEGI 366
G + C A + +H ++ V P I V PE+ TA L C A G
Sbjct: 205 GIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGN 264
Query: 367 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
P+P + W + +D P + + + G+ + IS+V + +G Y C A
Sbjct: 265 PRPIVSWSR--LDGRPIGVEGIQVLGTGNLI-ISDVTVQHSGVYVCAA 309
Score = 47.0 bits (110), Expect = 7e-05
Identities = 30/83 (36%), Positives = 40/83 (48%), Gaps = 9/83 (10%)
Query: 344 VYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVR 403
V P PG L C EG P ++ W KNG+++ S TL ANGS + I + R
Sbjct: 46 VEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPE--STHSTLLANGS-LMIRHFR 102
Query: 404 YE------DTGAYTCIAKNEAGV 420
E D G Y C+A+N G+
Sbjct: 103 LEPGGSPSDEGDYECVAQNRFGL 125
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 83.2 bits (204), Expect = 9e-16
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 9/185 (4%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
E+ K + G VL+C + G P + W ++ + + + + + G G L +++
Sbjct: 1936 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG--GRLQLSR 1993
Query: 310 VTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE----PGVTASLRCHAE 364
+ G YTC A+ + + + + V V P IR ARE G L C A+
Sbjct: 1994 LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIR--SSGVAREHHVLEGQEVRLDCEAD 2051
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
G P P + WLK+G + + L +G + + +R D GAYTC+A N AG D +
Sbjct: 2052 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL 2111
Query: 425 SSLFV 429
++ V
Sbjct: 2112 HTVNV 2116
Score = 76.3 bits (186), Expect = 1e-13
Identities = 55/188 (29%), Positives = 82/188 (43%), Gaps = 11/188 (5%)
Query: 236 EFYRAFQV---IQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 292
E +R +QV + ++ +DQ + T+ VL+C G P + W + L
Sbjct: 2653 EAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 2710
Query: 293 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAR 351
G+L I + H G YTC A V H+F V PV++ P
Sbjct: 2711 SG--YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA 2768
Query: 352 EPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYT 411
L C A GIP+P + W K G+++ +S Q+ G ++ I++ ED G Y
Sbjct: 2769 VAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV---LPGGQLRIAHASPEDAGNYL 2825
Query: 412 CIAKNEAG 419
CIAKN AG
Sbjct: 2826 CIAKNSAG 2833
Score = 73.6 bits (179), Expect = 7e-13
Identities = 49/173 (28%), Positives = 78/173 (45%), Gaps = 6/173 (3%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
GQ L C G P + W ++ L + + D GSL + + + G YTC
Sbjct: 2041 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2100
Query: 322 ADGYE-QVYQTHIFQVNVPPVIRVYPESQAR---EPGVTASLRCHAEGIPKPQLGWLKNG 377
A + + H V VPP I+ + PG ++ C G P + WLK+G
Sbjct: 2101 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG 2160
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ + LS++ L +G + IS V+ D G +TC+A + AGV + +L V+
Sbjct: 2161 LPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ 2211
Score = 70.9 bits (172), Expect = 5e-12
Identities = 51/191 (26%), Positives = 84/191 (43%), Gaps = 7/191 (3%)
Query: 243 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD 302
V+Q+ + L + T G A L C +G+ P I W ++ ++ E
Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA--EGKFTIQPS 2899
Query: 303 GSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRC 361
G L + + G YTC A+ + + + V PV P ++ G LRC
Sbjct: 2900 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRC 2959
Query: 362 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
A G P P++GW N +T +S+ Q GS + + V ED+G Y C A+N G
Sbjct: 2960 AARGSPTPRIGWTVNDRPVTEGVSE----QDGGSTLQRAAVSREDSGTYVCWAENRVGRT 3015
Query: 422 EDISSLFVEDS 432
+ +S + V+++
Sbjct: 3016 QAVSFVHVKEA 3026
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/159 (30%), Positives = 77/159 (48%), Gaps = 9/159 (5%)
Query: 266 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN-DFGDDGS-LYITKVTTTHVGNYTCYA- 322
VL C+++ P I W R+ I+L ED + F + G L + ++T G+Y+C A
Sbjct: 2409 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 2464
Query: 323 DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP 382
+ +++ P IR P + TA L C A+G+P P + W K+ + + P
Sbjct: 2465 NAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP 2524
Query: 383 KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
+ S + + GS + I V +D G Y C+A N AG D
Sbjct: 2525 R-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2561
Score = 68.9 bits (167), Expect = 2e-11
Identities = 50/171 (29%), Positives = 75/171 (43%), Gaps = 7/171 (4%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
+ + S VG S L C ++G P I W ++ + L L +GSL I +
Sbjct: 3030 QGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ---NGSLTIHR 3086
Query: 310 VTTTHVGNYTCYADGYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPK 368
G Y C A+ V + + V PV +V P+ G +LRC A G P
Sbjct: 3087 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 3146
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
P + WL+ G + + S++L +GS + + NV D G Y C+A N G
Sbjct: 3147 PTIEWLQAGQPL--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 3194
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/203 (28%), Positives = 89/203 (43%), Gaps = 14/203 (6%)
Query: 236 EFYRAFQVIQLSLPEDQKLSITA---ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 292
+F AF++ LS E+ + +T A L C P + W R + L+ D
Sbjct: 1547 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 1604
Query: 293 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAR 351
+++ L I V + G Y+C A H V PPVI E
Sbjct: 1605 --EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 1662
Query: 352 EPGV----TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDT 407
E V T SL+C A G P P + WL+NG+ +P S +L + +G + +S D
Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 1720
Query: 408 GAYTCIAKNEAGVDEDISSLFVE 430
+Y C+A+N+AG E + +L V+
Sbjct: 1721 ASYMCVAENQAGSAEKLFTLRVQ 1743
Score = 64.3 bits (155), Expect = 4e-10
Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 10/164 (6%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIIL--NNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
G LSC +G P I W+++ L L+ ++ G LY+ + G YT
Sbjct: 986 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQEGTYT 1043
Query: 320 CYADGYE-QVYQTHIFQVNVPPVI---RVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 375
C Q +V+VPP I R P + A+L C+A G P P + W +
Sbjct: 1044 CECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 1103
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+G + +L QL Q G +H+ + TG Y+C+A+N AG
Sbjct: 1104 DGQPVGAELGLQL--QNQGQSLHVERAQAAHTGRYSCVAENLAG 1145
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/188 (27%), Positives = 81/188 (43%), Gaps = 14/188 (7%)
Query: 247 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 306
+LP D+ L + G L CA +G+ P I W N+ + E +++ +L
Sbjct: 2942 TLPGDRSLRL-----GDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQ 2992
Query: 307 ITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAREP-GVTASLRCHAE 364
V+ G Y C+A+ Q F V PV++ S EP G + L C
Sbjct: 2993 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 3052
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
G P P + W+K+G+ P L Q + I +D G Y C+A+NE GV + +
Sbjct: 3053 GDPVPDIHWIKDGL---PLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKV 3109
Query: 425 SSLFVEDS 432
L ++ +
Sbjct: 3110 VILVLQSA 3117
Score = 60.5 bits (145), Expect = 6e-09
Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 12/164 (7%)
Query: 264 SAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYAD 323
S L C G P + W + + +++ + D L I + + G+Y C A
Sbjct: 711 SVTLECLASGVPPPDVSWFKGHQPVSSW--MGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 768
Query: 324 GYEQVYQTHI-FQVNVPPVIRVYPESQAREPG-----VTASLRCHAEGIPKPQLGWLKNG 377
+ +VNVPP I + P PG L C+A G P P L WLK+G
Sbjct: 769 NVAGSTELRYGLRVNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDG 824
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
++P + L + G + +++ R D+G Y+C+A + G D
Sbjct: 825 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 868
Score = 59.3 bits (142), Expect = 1e-08
Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 3/119 (2%)
Query: 305 LYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHA 363
L I KV G YTC A + + +V VPP I P ++A + +L C A
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 718
Query: 364 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
G+P P + W K ++ + +T+ +G + I + D G+Y C+A N AG E
Sbjct: 719 SGVPPPDVSWFKGHQPVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 775
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/235 (25%), Positives = 94/235 (40%), Gaps = 24/235 (10%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTHVGN-- 317
G L C G P + W ++ ++ L+ +DG + ++T +HVG+
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ----VQEDGQ--VLRITGSHVGDEG 285
Query: 318 -YTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLG 372
Y C A Q FQ+ V ++ ++ E V L C A G+P P +
Sbjct: 286 RYQCVAFS-PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT 344
Query: 373 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 432
W K+G + S ++ G ++ + + D G YTC A N G E + L V
Sbjct: 345 WFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV--Y 400
Query: 433 ARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDE 487
T G G YV + + +EC + H P+ L + E P AE +E
Sbjct: 401 VPPTIEGAGGRPYVVKAVAGRPV-ALECVARGHPSPT---LSWHHEGLPVAESNE 451
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/165 (29%), Positives = 69/165 (41%), Gaps = 20/165 (12%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G L C +G P + W ++ L + LE SL + V G Y+C
Sbjct: 2230 GSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ------GPSLQLEAVGAGDSGTYSCV 2283
Query: 322 ADGYEQVYQTHIFQVNV--PPVIRV--YPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 377
A + H FQ+ V PP I P + PG L C A+G P+P + W K+G
Sbjct: 2284 AVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2342
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+T L+ N + VR D G YTC+A++ AG E
Sbjct: 2343 QALT-------RLENNSRATRVLRVR--DAGLYTCLAESPAGAIE 2378
Score = 57.8 bits (138), Expect = 4e-08
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 3/161 (1%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
+V Q+A+L C G P + W+++ + L+ + +GSL I V G+Y
Sbjct: 2494 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRF--EILPEGSLRIQPVLAQDAGHYL 2551
Query: 320 CYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
C A Q +V PP I P + A L C A G PKP + W K+G
Sbjct: 2552 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQ 2611
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ +L + + + ++ +D+ + C+ NE G
Sbjct: 2612 KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 2652
Score = 57.4 bits (137), Expect = 5e-08
Identities = 55/215 (25%), Positives = 82/215 (38%), Gaps = 24/215 (11%)
Query: 233 ALEEFYRAFQVIQLSLP------EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNI 286
A+ E + FQ+ L P ED TV L C P I W ++
Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389
Query: 287 ILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRV 344
+I L I G YTC E V H+ +V +PP I
Sbjct: 1390 PFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHV-EVLIPPSIS- 1445
Query: 345 YPESQAREPGV---------TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 395
+ E GV T +L C + +P P + W K+G +TP S +L + G
Sbjct: 1446 -KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGR 1502
Query: 396 EVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ I + D+G Y C+A N AG D+ ++ ++
Sbjct: 1503 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 1537
Score = 56.6 bits (135), Expect = 9e-08
Identities = 38/157 (24%), Positives = 68/157 (43%), Gaps = 3/157 (1%)
Query: 267 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGY 325
L+C G P ++W ++ ++ + F L + + G Y+C A
Sbjct: 806 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 865
Query: 326 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 385
+ Q + QV++PP I + + + +L C + +P P L W K+G + P+
Sbjct: 866 GEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 925
Query: 386 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
L+ A+ + + + D G YTC A N+AG E
Sbjct: 926 VHLS--ADKALLQVDRADVWDAGHYTCEALNQAGRSE 960
Score = 55.8 bits (133), Expect = 2e-07
Identities = 47/169 (27%), Positives = 69/169 (40%), Gaps = 11/169 (6%)
Query: 256 ITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LYITKVTTTH 314
+ A G+ L C +G P + W + + + + DGS L +
Sbjct: 414 VVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET---DGSVLRLESPGEAS 470
Query: 315 VGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPE--SQAREPGVTASLRCHAEGIPKPQ 370
G Y+C A E V Q + +V VPP + V G L C A G P P
Sbjct: 471 SGLYSCVASSPAGEAVLQYSV-EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT 529
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ WL+NG Q+ Q G+ +HI +V + +G + C A NEAG
Sbjct: 530 IQWLQNGRPAEELAGVQVASQ--GTTLHIDHVELDHSGLFACQATNEAG 576
Score = 52.8 bits (125), Expect = 1e-06
Identities = 50/204 (24%), Positives = 78/204 (38%), Gaps = 34/204 (16%)
Query: 247 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN----------NLDLEDI 296
S+ ED + + + GQS L C G P I+W ++ ++ +L +
Sbjct: 96 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 155
Query: 297 NDFG--DDG-SLYITKVTTTHVGNYTCYADG--------------YEQVYQTHIFQVNVP 339
D+G SL+ ++ G A G +EQ H F P
Sbjct: 156 GGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAP 215
Query: 340 PVIRVYPESQARE----PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 395
P V A+E G L+C G+P PQ+ W K+ + P L +Q +G
Sbjct: 216 P--SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQ 272
Query: 396 EVHISNVRYEDTGAYTCIAKNEAG 419
+ I+ D G Y C+A + AG
Sbjct: 273 VLRITGSHVGDEGRYQCVAFSPAG 296
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/173 (24%), Positives = 67/173 (38%), Gaps = 6/173 (3%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 308
P L++TA T A+L C G+ +P ++W ++ L+ + +L +T
Sbjct: 2577 PSPSNLTLTAHT---PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLT 2633
Query: 309 KVTTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 367
+ C + ++ + V+VPP I L CH+ GIP
Sbjct: 2634 APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIP 2693
Query: 368 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 420
P + W K G + + S + E I G YTC A+N AGV
Sbjct: 2694 APTVSWSKAGAQLGARGSGYRVSPSGALE--IGQALPIHAGRYTCSARNSAGV 2744
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 8/183 (4%)
Query: 251 DQKLSITAATVGQSAVLS--CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 308
D + + TV S+ +S C G P I W +N + + + + G L ++
Sbjct: 1656 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVS 1713
Query: 309 KVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREP-GVTASLRCHAEGI 366
+Y C A+ + +V VPP I Q + SL C
Sbjct: 1714 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAH 1773
Query: 367 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISS 426
P P++ W K+ ++ L +++ L + + R D+G YTC A N AG D+ +
Sbjct: 1774 PNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1831
Query: 427 LFV 429
L V
Sbjct: 1832 LSV 1834
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 9/171 (5%)
Query: 254 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 313
L A + S L C + P + W +++ L+ E++ +L + + +
Sbjct: 1753 LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLS 1810
Query: 314 HVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYP----ESQAREPGVTASLRCHAEGIPK 368
G YTC A Q + V VPP R P ++ G A L C + +P+
Sbjct: 1811 DSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1870
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
P + W K+G + L+++ G + I + D G Y+C N AG
Sbjct: 1871 PTVTWYKDGQPLV--LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 1919
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 16/164 (9%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
T G L C QGT +P I W ++ L L ++ S + G YT
Sbjct: 2317 TPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGLYT 2367
Query: 320 CYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS---LRCHAEGIPKPQLGWLK 375
C A+ + ++ +V PP I V P G+ L C E P P++ W +
Sbjct: 2368 CLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 2426
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+GI + Q G + + + D+G Y+C A+N AG
Sbjct: 2427 DGIVLQEDAHTQ--FPERGRFLQLQALSTADSGDYSCTARNAAG 2468
Score = 49.3 bits (116), Expect = 1e-05
Identities = 44/186 (23%), Positives = 76/186 (40%), Gaps = 16/186 (8%)
Query: 243 VIQLSLP-----EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN 297
V+Q+ +P E+ +S+ A +S L C P + W ++ L ++
Sbjct: 873 VLQVHMPPSILGEELNVSVVA---NESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVH 927
Query: 298 DFGDDGSLYITKVTTTHVGNYTC----YADGYEQVYQTHIFQVNVPPVIRVYPESQAREP 353
D L + + G+YTC A E+ Y +++ V P +R RE
Sbjct: 928 LSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFP-LRESHTLTVRE- 985
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
G SL C G+P P++ W K+G + + + + A G +++ + G YTC
Sbjct: 986 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045
Query: 414 AKNEAG 419
N G
Sbjct: 1046 CSNVVG 1051
Score = 47.8 bits (112), Expect = 4e-05
Identities = 50/189 (26%), Positives = 76/189 (40%), Gaps = 13/189 (6%)
Query: 239 RAFQVIQLSLPE-----DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDL 293
R F++ L PE D +ITAA + L C G P I W R ++
Sbjct: 1149 RKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PG 1205
Query: 294 EDINDFGDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE 352
ED L +T+ G Y+C A + + +V VPP I + +
Sbjct: 1206 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 1265
Query: 353 --PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 410
G TA L C+ G P+P+L W K+G + + ++ +G + + G Y
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHY 1323
Query: 411 TCIAKNEAG 419
+CIA N G
Sbjct: 1324 SCIAANAVG 1332
Score = 43.9 bits (102), Expect = 6e-04
Identities = 37/130 (28%), Positives = 57/130 (43%), Gaps = 5/130 (3%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
E + L A TVG A C GT +P + W++ L + ++GSL++
Sbjct: 6 EIKGLGDVALTVGLEAG-GCGTHGTPKPQVTWRKGPSS-EPLHGQPGVAVLEEGSLFLAS 63
Query: 310 VTTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRV--YPESQAREPGVTASLRCHAEGI 366
V+ G+Y C A + V VPP IR + + G + +L C A G
Sbjct: 64 VSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGF 123
Query: 367 PKPQLGWLKN 376
P P++ WLK+
Sbjct: 124 PVPEIVWLKD 133
Score = 33.5 bits (75), Expect = 0.84
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 361 CHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
C G PKPQ+ W K G P + + +++V D+G Y C A NE G
Sbjct: 24 CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 81
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 83.2 bits (204), Expect = 9e-16
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 9/185 (4%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
E+ K + G VL+C + G P + W ++ + + + + + G G L +++
Sbjct: 3127 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG--GRLQLSR 3184
Query: 310 VTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE----PGVTASLRCHAE 364
+ G YTC A+ + + + + V V P IR ARE G L C A+
Sbjct: 3185 LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIR--SSGVAREHHVLEGQEVRLDCEAD 3242
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
G P P + WLK+G + + L +G + + +R D GAYTC+A N AG D +
Sbjct: 3243 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL 3302
Query: 425 SSLFV 429
++ V
Sbjct: 3303 HTVNV 3307
Score = 76.3 bits (186), Expect = 1e-13
Identities = 55/188 (29%), Positives = 82/188 (43%), Gaps = 11/188 (5%)
Query: 236 EFYRAFQV---IQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 292
E +R +QV + ++ +DQ + T+ VL+C G P + W + L
Sbjct: 3844 EAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 3901
Query: 293 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAR 351
G+L I + H G YTC A V H+F V PV++ P
Sbjct: 3902 SG--YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA 3959
Query: 352 EPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYT 411
L C A GIP+P + W K G+++ +S Q+ G ++ I++ ED G Y
Sbjct: 3960 VAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV---LPGGQLRIAHASPEDAGNYL 4016
Query: 412 CIAKNEAG 419
CIAKN AG
Sbjct: 4017 CIAKNSAG 4024
Score = 73.6 bits (179), Expect = 7e-13
Identities = 49/173 (28%), Positives = 78/173 (45%), Gaps = 6/173 (3%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
GQ L C G P + W ++ L + + D GSL + + + G YTC
Sbjct: 3232 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 3291
Query: 322 ADGYE-QVYQTHIFQVNVPPVIRVYPESQAR---EPGVTASLRCHAEGIPKPQLGWLKNG 377
A + + H V VPP I+ + PG ++ C G P + WLK+G
Sbjct: 3292 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG 3351
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ + LS++ L +G + IS V+ D G +TC+A + AGV + +L V+
Sbjct: 3352 LPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ 3402
Score = 70.9 bits (172), Expect = 5e-12
Identities = 51/191 (26%), Positives = 84/191 (43%), Gaps = 7/191 (3%)
Query: 243 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD 302
V+Q+ + L + T G A L C +G+ P I W ++ ++ E
Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA--EGKFTIQPS 4090
Query: 303 GSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRC 361
G L + + G YTC A+ + + + V PV P ++ G LRC
Sbjct: 4091 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRC 4150
Query: 362 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
A G P P++GW N +T +S+ Q GS + + V ED+G Y C A+N G
Sbjct: 4151 AARGSPTPRIGWTVNDRPVTEGVSE----QDGGSTLQRAAVSREDSGTYVCWAENRVGRT 4206
Query: 422 EDISSLFVEDS 432
+ +S + V+++
Sbjct: 4207 QAVSFVHVKEA 4217
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/159 (30%), Positives = 77/159 (48%), Gaps = 9/159 (5%)
Query: 266 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN-DFGDDGS-LYITKVTTTHVGNYTCYA- 322
VL C+++ P I W R+ I+L ED + F + G L + ++T G+Y+C A
Sbjct: 3600 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 3655
Query: 323 DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP 382
+ +++ P IR P + TA L C A+G+P P + W K+ + + P
Sbjct: 3656 NAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP 3715
Query: 383 KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
+ S + + GS + I V +D G Y C+A N AG D
Sbjct: 3716 R-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 3752
Score = 69.3 bits (168), Expect = 1e-11
Identities = 56/201 (27%), Positives = 88/201 (43%), Gaps = 18/201 (8%)
Query: 239 RAFQVIQLSLPEDQKLSITAATV--GQSAVLSCAIQGTLRPPIIWKRNNIIL-----NNL 291
RA I ++ P Q + TV G++AVLSC + G + W R+ +L
Sbjct: 506 RAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA 565
Query: 292 DLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQ-VNVPPVIRVYPESQA 350
L D+ SL I+ + T G Y C A V + ++ V P + ++ SQ
Sbjct: 566 QLADL-------SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQH 618
Query: 351 REPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 410
GV + C A G P P + W + + ++ + A G+ + I V ED G Y
Sbjct: 619 FSQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIHVDAQGTLI-IQGVAPEDAGNY 675
Query: 411 TCIAKNEAGVDEDISSLFVED 431
+C A NE G D++ +L+ D
Sbjct: 676 SCQATNEVGTDQETVTLYYTD 696
Score = 68.9 bits (167), Expect = 2e-11
Identities = 50/171 (29%), Positives = 75/171 (43%), Gaps = 7/171 (4%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
+ + S VG S L C ++G P I W ++ + L L +GSL I +
Sbjct: 4221 QGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ---NGSLTIHR 4277
Query: 310 VTTTHVGNYTCYADGYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPK 368
G Y C A+ V + + V PV +V P+ G +LRC A G P
Sbjct: 4278 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 4337
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
P + WL+ G + + S++L +GS + + NV D G Y C+A N G
Sbjct: 4338 PTIEWLQAGQPL--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 4385
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/203 (28%), Positives = 89/203 (43%), Gaps = 14/203 (6%)
Query: 236 EFYRAFQVIQLSLPEDQKLSITA---ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 292
+F AF++ LS E+ + +T A L C P + W R + L+ D
Sbjct: 2738 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 2795
Query: 293 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAR 351
+++ L I V + G Y+C A H V PPVI E
Sbjct: 2796 --EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 2853
Query: 352 EPGV----TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDT 407
E V T SL+C A G P P + WL+NG+ +P S +L + +G + +S D
Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 2911
Query: 408 GAYTCIAKNEAGVDEDISSLFVE 430
+Y C+A+N+AG E + +L V+
Sbjct: 2912 ASYMCVAENQAGSAEKLFTLRVQ 2934
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/122 (34%), Positives = 55/122 (45%), Gaps = 13/122 (10%)
Query: 303 GSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRC 361
GSL + +V G+Y C A ++ V VPP ++ P G L C
Sbjct: 1082 GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNC 1141
Query: 362 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE--VHISNVRYEDTGAYTCIAKNEAG 419
AEG P+PQL W K+G+ LQ G + VH + +R D G Y C A N AG
Sbjct: 1142 VAEGNPEPQLSWSKDGV----------VLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAG 1191
Query: 420 VD 421
VD
Sbjct: 1192 VD 1193
Score = 64.3 bits (155), Expect = 4e-10
Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 10/164 (6%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIIL--NNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
G LSC +G P I W+++ L L+ ++ G LY+ + G YT
Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQEGTYT 2234
Query: 320 CYADGYE-QVYQTHIFQVNVPPVI---RVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 375
C Q +V+VPP I R P + A+L C+A G P P + W +
Sbjct: 2235 CECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 2294
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+G + +L QL Q G +H+ + TG Y+C+A+N AG
Sbjct: 2295 DGQPVGAELGLQL--QNQGQSLHVERAQAAHTGRYSCVAENLAG 2336
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/188 (27%), Positives = 81/188 (43%), Gaps = 14/188 (7%)
Query: 247 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 306
+LP D+ L + G L CA +G+ P I W N+ + E +++ +L
Sbjct: 4133 TLPGDRSLRL-----GDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQ 4183
Query: 307 ITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAREP-GVTASLRCHAE 364
V+ G Y C+A+ Q F V PV++ S EP G + L C
Sbjct: 4184 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 4243
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
G P P + W+K+G+ P L Q + I +D G Y C+A+NE GV + +
Sbjct: 4244 GDPVPDIHWIKDGL---PLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKV 4300
Query: 425 SSLFVEDS 432
L ++ +
Sbjct: 4301 VILVLQSA 4308
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/162 (28%), Positives = 68/162 (41%), Gaps = 12/162 (7%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
VG++ L+C +G P + W ++ ++L G GS++ + T+ G Y C
Sbjct: 1133 VGEALDLNCVAEGNPEPQLSWSKDGVVLQGR--------GPQGSVHFAAIRTSDAGRYRC 1184
Query: 321 YADGYEQVYQTHI-FQVNVPPVIRVYPESQARE--PGVTASLRCHAEGIPKPQLGWLKNG 377
A V + +V PP S E G ASL C A G PKPQ+ W K G
Sbjct: 1185 EASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRK-G 1243
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
P + + +++V D+G Y C A NE G
Sbjct: 1244 PSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 1285
Score = 60.5 bits (145), Expect = 6e-09
Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 12/164 (7%)
Query: 264 SAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYAD 323
S L C G P + W + + +++ + D L I + + G+Y C A
Sbjct: 1902 SVTLECLASGVPPPDVSWFKGHQPVSSW--MGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 1959
Query: 324 GYEQVYQTHI-FQVNVPPVIRVYPESQAREPG-----VTASLRCHAEGIPKPQLGWLKNG 377
+ +VNVPP I + P PG L C+A G P P L WLK+G
Sbjct: 1960 NVAGSTELRYGLRVNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDG 2015
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
++P + L + G + +++ R D+G Y+C+A + G D
Sbjct: 2016 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 2059
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/185 (25%), Positives = 79/185 (42%), Gaps = 17/185 (9%)
Query: 251 DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
D+ + G++A L C +GT +P + W++ L + ++GSL++ V
Sbjct: 1210 DETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSS-EPLHGQPGVAVLEEGSLFLASV 1268
Query: 311 TTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRV--YPESQAREPGVTASLRCHAEGIP 367
+ G+Y C A + V VPP IR + + G + +L C A G P
Sbjct: 1269 SPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFP 1328
Query: 368 KPQLGWLKN-------------GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
P++ WLK+ G D+ L G +H ++ D+G Y+C A
Sbjct: 1329 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA 1388
Query: 415 KNEAG 419
+N+AG
Sbjct: 1389 ENQAG 1393
Score = 59.3 bits (142), Expect = 1e-08
Identities = 48/157 (30%), Positives = 64/157 (40%), Gaps = 21/157 (13%)
Query: 302 DGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLR 360
DGSL++ + H G Y+C A + V VPP I GV ASL
Sbjct: 937 DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLP 996
Query: 361 CHAEGIPKPQLGWLKNGIDITPK-----LSKQLTLQANGSEVHISNVRYEDTGAYTCIAK 415
C A G+P P + W K +T + +SK+ TL I+ +D GAY C A
Sbjct: 997 CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-------IAQPSAQDAGAYVCTAT 1049
Query: 416 NEAGVDEDISSLFVEDSARKTRLGIGNMFYVFYEDGI 452
N G L V RL + YV+ E G+
Sbjct: 1050 NTVGFSSQEMRLSV------NRLALSK--YVWEEYGL 1078
Score = 59.3 bits (142), Expect = 1e-08
Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 3/119 (2%)
Query: 305 LYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHA 363
L I KV G YTC A + + +V VPP I P ++A + +L C A
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 1909
Query: 364 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
G+P P + W K ++ + +T+ +G + I + D G+Y C+A N AG E
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 1966
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/235 (25%), Positives = 94/235 (40%), Gaps = 24/235 (10%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTHVGN-- 317
G L C G P + W ++ ++ L+ +DG + ++T +HVG+
Sbjct: 1423 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ----VQEDGQ--VLRITGSHVGDEG 1476
Query: 318 -YTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLG 372
Y C A Q FQ+ V ++ ++ E V L C A G+P P +
Sbjct: 1477 RYQCVAFS-PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT 1535
Query: 373 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 432
W K+G + S ++ G ++ + + D G YTC A N G E + L V
Sbjct: 1536 WFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV--Y 1591
Query: 433 ARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDE 487
T G G YV + + +EC + H P+ L + E P AE +E
Sbjct: 1592 VPPTIEGAGGRPYVVKAVAGRPV-ALECVARGHPSPT---LSWHHEGLPVAESNE 1642
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/165 (29%), Positives = 69/165 (41%), Gaps = 20/165 (12%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G L C +G P + W ++ L + LE SL + V G Y+C
Sbjct: 3421 GSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ------GPSLQLEAVGAGDSGTYSCV 3474
Query: 322 ADGYEQVYQTHIFQVNV--PPVIRV--YPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 377
A + H FQ+ V PP I P + PG L C A+G P+P + W K+G
Sbjct: 3475 AVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 3533
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+T L+ N + VR D G YTC+A++ AG E
Sbjct: 3534 QALT-------RLENNSRATRVLRVR--DAGLYTCLAESPAGAIE 3569
Score = 57.8 bits (138), Expect = 4e-08
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 3/161 (1%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
+V Q+A+L C G P + W+++ + L+ + +GSL I V G+Y
Sbjct: 3685 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRF--EILPEGSLRIQPVLAQDAGHYL 3742
Query: 320 CYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
C A Q +V PP I P + A L C A G PKP + W K+G
Sbjct: 3743 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQ 3802
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ +L + + + ++ +D+ + C+ NE G
Sbjct: 3803 KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 3843
Score = 57.4 bits (137), Expect = 5e-08
Identities = 55/215 (25%), Positives = 82/215 (38%), Gaps = 24/215 (11%)
Query: 233 ALEEFYRAFQVIQLSLP------EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNI 286
A+ E + FQ+ L P ED TV L C P I W ++
Sbjct: 2521 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 2580
Query: 287 ILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRV 344
+I L I G YTC E V H+ +V +PP I
Sbjct: 2581 PFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHV-EVLIPPSIS- 2636
Query: 345 YPESQAREPGV---------TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 395
+ E GV T +L C + +P P + W K+G +TP S +L + G
Sbjct: 2637 -KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGR 2693
Query: 396 EVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ I + D+G Y C+A N AG D+ ++ ++
Sbjct: 2694 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 2728
Score = 57.0 bits (136), Expect = 7e-08
Identities = 48/164 (29%), Positives = 68/164 (41%), Gaps = 19/164 (11%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGD-DGSLYITKVTTTHVGNYTC 320
G +SC+ G P I W R + L ED D G+L I V GNY+C
Sbjct: 622 GVEVKVSCSASGYPTPHISWSRESQALQ----EDSRIHVDAQGTLIIQGVAPEDAGNYSC 677
Query: 321 YAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 377
A G +Q +T PP + G A L C A G+P P++ W + G
Sbjct: 678 QATNEVGTDQ--ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 735
Query: 378 ID--ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
++ + P+ S + ++ I + D G YTC A NE G
Sbjct: 736 LEMILAPEGS-------SSGKLRIPAAQERDAGTYTCRAVNELG 772
Score = 57.0 bits (136), Expect = 7e-08
Identities = 46/189 (24%), Positives = 78/189 (41%), Gaps = 17/189 (8%)
Query: 247 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN----------NLDLEDI 296
S+ ED + + + GQS L C G P I+W ++ ++ +L +
Sbjct: 1300 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 1359
Query: 297 NDFG--DDG-SLYITKVTTTHVGNYTCYADGYEQVYQT--HIFQVNVPPVIRVYPESQAR 351
D+G SL+ ++ G Y+C A+ Q H+ + P V+ +
Sbjct: 1360 GGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVL 1419
Query: 352 E-PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 410
G L+C G+P PQ+ W K+ + P L +Q +G + I+ D G Y
Sbjct: 1420 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQVLRITGSHVGDEGRY 1478
Query: 411 TCIAKNEAG 419
C+A + AG
Sbjct: 1479 QCVAFSPAG 1487
Score = 56.6 bits (135), Expect = 9e-08
Identities = 38/157 (24%), Positives = 68/157 (43%), Gaps = 3/157 (1%)
Query: 267 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGY 325
L+C G P ++W ++ ++ + F L + + G Y+C A
Sbjct: 1997 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 2056
Query: 326 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 385
+ Q + QV++PP I + + + +L C + +P P L W K+G + P+
Sbjct: 2057 GEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 2116
Query: 386 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
L+ A+ + + + D G YTC A N+AG E
Sbjct: 2117 VHLS--ADKALLQVDRADVWDAGHYTCEALNQAGHSE 2151
Score = 55.8 bits (133), Expect = 2e-07
Identities = 47/169 (27%), Positives = 69/169 (40%), Gaps = 11/169 (6%)
Query: 256 ITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LYITKVTTTH 314
+ A G+ L C +G P + W + + + + DGS L +
Sbjct: 1605 VVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET---DGSVLRLESPGEAS 1661
Query: 315 VGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPE--SQAREPGVTASLRCHAEGIPKPQ 370
G Y+C A E V Q + +V VPP + V G L C A G P P
Sbjct: 1662 SGLYSCVASSPAGEAVLQYSV-EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT 1720
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ WL+NG Q+ Q G+ +HI +V + +G + C A NEAG
Sbjct: 1721 IQWLQNGRPAEELAGVQVASQ--GTTLHIDHVELDHSGLFACQATNEAG 1767
Score = 55.1 bits (131), Expect = 3e-07
Identities = 56/199 (28%), Positives = 83/199 (41%), Gaps = 15/199 (7%)
Query: 233 ALEEFYRAFQVIQLSLPEDQKLSITAATV----GQSAVLSCAIQGTLRPPIIWKRNNIIL 288
A+ E A IQL++ +L+ V G+SA+L+C G P + W+R +
Sbjct: 767 AVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 826
Query: 289 NNLDLE----DINDFGDDGSLYITKVTTTHVGNYTCYAD---GYEQVYQTHIFQVNVPPV 341
L L + D G L+ V Y C A G Q I + PP
Sbjct: 827 LGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 886
Query: 342 IRVYPESQAREPGVTASLRCHA-EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHIS 400
I + G SL C G P P+ WLK+G + P + +++A+GS +H+
Sbjct: 887 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP--GSRHSIRADGS-LHLD 943
Query: 401 NVRYEDTGAYTCIAKNEAG 419
E G Y+C+A N AG
Sbjct: 944 RALQEHAGRYSCVATNTAG 962
Score = 51.2 bits (121), Expect = 4e-06
Identities = 48/184 (26%), Positives = 69/184 (37%), Gaps = 10/184 (5%)
Query: 255 SITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH 314
++ VG+ AVL C G P +IW R L++ + G L I
Sbjct: 705 AVVLVAVGEEAVLVCEASGVPPPRVIWYR-----GGLEMILAPEGSSSGKLRIPAAQERD 759
Query: 315 VGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 373
G YTC A I V P + P E G +A L C A G P P + W
Sbjct: 760 AGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW 819
Query: 374 LK-NGIDITPKLSK---QLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
+ +G + +L + Q + + +V ED Y C A+N G + + L V
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Query: 430 EDSA 433
A
Sbjct: 880 TGHA 883
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/173 (24%), Positives = 67/173 (38%), Gaps = 6/173 (3%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 308
P L++TA T A+L C G+ +P ++W ++ L+ + +L +T
Sbjct: 3768 PSPSNLTLTAHT---PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLT 3824
Query: 309 KVTTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 367
+ C + ++ + V+VPP I L CH+ GIP
Sbjct: 3825 APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIP 3884
Query: 368 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 420
P + W K G + + S + E I G YTC A+N AGV
Sbjct: 3885 APTVSWSKAGAQLGARGSGYRVSPSGALE--IGQALPIHAGRYTCSARNSAGV 3935
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 8/183 (4%)
Query: 251 DQKLSITAATVGQSAVLS--CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 308
D + + TV S+ +S C G P I W +N + + + + G L ++
Sbjct: 2847 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVS 2904
Query: 309 KVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREP-GVTASLRCHAEGI 366
+Y C A+ + +V VPP I Q + SL C
Sbjct: 2905 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAH 2964
Query: 367 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISS 426
P P++ W K+ ++ L +++ L + + R D+G YTC A N AG D+ +
Sbjct: 2965 PNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 3022
Query: 427 LFV 429
L V
Sbjct: 3023 LSV 3025
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 9/171 (5%)
Query: 254 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 313
L A + S L C + P + W +++ L+ E++ +L + + +
Sbjct: 2944 LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLS 3001
Query: 314 HVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYP----ESQAREPGVTASLRCHAEGIPK 368
G YTC A Q + V VPP R P ++ G A L C + +P+
Sbjct: 3002 DSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 3061
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
P + W K+G + L+++ G + I + D G Y+C N AG
Sbjct: 3062 PTVTWYKDGQPLV--LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 3110
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 16/164 (9%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
T G L C QGT +P I W ++ L L ++ S + G YT
Sbjct: 3508 TPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGLYT 3558
Query: 320 CYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS---LRCHAEGIPKPQLGWLK 375
C A+ + ++ +V PP I V P G+ L C E P P++ W +
Sbjct: 3559 CLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 3617
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+GI + Q G + + + D+G Y+C A+N AG
Sbjct: 3618 DGIVLQEDAHTQ--FPERGRFLQLQALSTADSGDYSCTARNAAG 3659
Score = 49.3 bits (116), Expect = 1e-05
Identities = 44/186 (23%), Positives = 76/186 (40%), Gaps = 16/186 (8%)
Query: 243 VIQLSLP-----EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN 297
V+Q+ +P E+ +S+ A +S L C P + W ++ L ++
Sbjct: 2064 VLQVHMPPSILGEELNVSVVA---NESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVH 2118
Query: 298 DFGDDGSLYITKVTTTHVGNYTC----YADGYEQVYQTHIFQVNVPPVIRVYPESQAREP 353
D L + + G+YTC A E+ Y +++ V P +R RE
Sbjct: 2119 LSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-LRESHTLTVRE- 2176
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
G SL C G+P P++ W K+G + + + + A G +++ + G YTC
Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 2236
Query: 414 AKNEAG 419
N G
Sbjct: 2237 CSNVVG 2242
Score = 47.8 bits (112), Expect = 4e-05
Identities = 50/189 (26%), Positives = 76/189 (40%), Gaps = 13/189 (6%)
Query: 239 RAFQVIQLSLPE-----DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDL 293
R F++ L PE D +ITAA + L C G P I W R ++
Sbjct: 2340 RKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PG 2396
Query: 294 EDINDFGDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE 352
ED L +T+ G Y+C A + + +V VPP I + +
Sbjct: 2397 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 2456
Query: 353 --PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 410
G TA L C+ G P+P+L W K+G + + ++ +G + + G Y
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHY 2514
Query: 411 TCIAKNEAG 419
+CIA N G
Sbjct: 2515 SCIAANAVG 2523
Score = 34.7 bits (78), Expect = 0.38
Identities = 41/173 (23%), Positives = 67/173 (38%), Gaps = 10/173 (5%)
Query: 263 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDG--SLYITKVTTTHVGNYTC 320
Q ++SC++ L + +R L + F + G S I + + G Y C
Sbjct: 442 QPLLVSCSVHSALPFRLQLRRGEARLG-----EERHFQESGNSSWEILRASKAEEGTYEC 496
Query: 321 YADGYEQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPKPQLGWLKNGID 379
A + V P ++ P PG TA L C G L W+++
Sbjct: 497 TAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDW-R 555
Query: 380 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 432
+ P + ++ A+ S + IS + D G Y C+A N GV L V ++
Sbjct: 556 VLPASTGRVAQLADLS-LEISGIIPTDGGRYQCVASNANGVTRASVWLLVREA 607
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 83.2 bits (204), Expect = 9e-16
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 9/185 (4%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
E+ K + G VL+C + G P + W ++ + + + + + G G L +++
Sbjct: 1845 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG--GRLQLSR 1902
Query: 310 VTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE----PGVTASLRCHAE 364
+ G YTC A+ + + + + V V P IR ARE G L C A+
Sbjct: 1903 LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIR--SSGVAREHHVLEGQEVRLDCEAD 1960
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
G P P + WLK+G + + L +G + + +R D GAYTC+A N AG D +
Sbjct: 1961 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL 2020
Query: 425 SSLFV 429
++ V
Sbjct: 2021 HTVNV 2025
Score = 76.3 bits (186), Expect = 1e-13
Identities = 55/188 (29%), Positives = 82/188 (43%), Gaps = 11/188 (5%)
Query: 236 EFYRAFQV---IQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 292
E +R +QV + ++ +DQ + T+ VL+C G P + W + L
Sbjct: 2562 EAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 2619
Query: 293 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAR 351
G+L I + H G YTC A V H+F V PV++ P
Sbjct: 2620 SG--YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA 2677
Query: 352 EPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYT 411
L C A GIP+P + W K G+++ +S Q+ G ++ I++ ED G Y
Sbjct: 2678 VAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV---LPGGQLRIAHASPEDAGNYL 2734
Query: 412 CIAKNEAG 419
CIAKN AG
Sbjct: 2735 CIAKNSAG 2742
Score = 73.6 bits (179), Expect = 7e-13
Identities = 49/173 (28%), Positives = 78/173 (45%), Gaps = 6/173 (3%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
GQ L C G P + W ++ L + + D GSL + + + G YTC
Sbjct: 1950 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2009
Query: 322 ADGYE-QVYQTHIFQVNVPPVIRVYPESQAR---EPGVTASLRCHAEGIPKPQLGWLKNG 377
A + + H V VPP I+ + PG ++ C G P + WLK+G
Sbjct: 2010 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG 2069
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ + LS++ L +G + IS V+ D G +TC+A + AGV + +L V+
Sbjct: 2070 LPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ 2120
Score = 70.9 bits (172), Expect = 5e-12
Identities = 51/191 (26%), Positives = 84/191 (43%), Gaps = 7/191 (3%)
Query: 243 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD 302
V+Q+ + L + T G A L C +G+ P I W ++ ++ E
Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA--EGKFTIQPS 2808
Query: 303 GSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRC 361
G L + + G YTC A+ + + + V PV P ++ G LRC
Sbjct: 2809 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRC 2868
Query: 362 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
A G P P++GW N +T +S+ Q GS + + V ED+G Y C A+N G
Sbjct: 2869 AARGSPTPRIGWTVNDRPVTEGVSE----QDGGSTLQRAAVSREDSGTYVCWAENRVGRT 2924
Query: 422 EDISSLFVEDS 432
+ +S + V+++
Sbjct: 2925 QAVSFVHVKEA 2935
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/159 (30%), Positives = 77/159 (48%), Gaps = 9/159 (5%)
Query: 266 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN-DFGDDGS-LYITKVTTTHVGNYTCYA- 322
VL C+++ P I W R+ I+L ED + F + G L + ++T G+Y+C A
Sbjct: 2318 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 2373
Query: 323 DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP 382
+ +++ P IR P + TA L C A+G+P P + W K+ + + P
Sbjct: 2374 NAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP 2433
Query: 383 KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
+ S + + GS + I V +D G Y C+A N AG D
Sbjct: 2434 R-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2470
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/171 (29%), Positives = 75/171 (43%), Gaps = 7/171 (4%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 309
+ + S VG S L C ++G P I W ++ + L L +GSL I +
Sbjct: 2939 QGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ---NGSLTIRR 2995
Query: 310 VTTTHVGNYTCYADGYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPK 368
G Y C A+ V + + V PV +V P+ G +LRC A G P
Sbjct: 2996 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 3055
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
P + WL+ G + + S++L +GS + + NV D G Y C+A N G
Sbjct: 3056 PTIEWLQAGQPL--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 3103
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/203 (28%), Positives = 89/203 (43%), Gaps = 14/203 (6%)
Query: 236 EFYRAFQVIQLSLPEDQKLSITA---ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 292
+F AF++ LS E+ + +T A L C P + W R + L+ D
Sbjct: 1456 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 1513
Query: 293 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAR 351
+++ L I V + G Y+C A H V PPVI E
Sbjct: 1514 --EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 1571
Query: 352 EPGV----TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDT 407
E V T SL+C A G P P + WL+NG+ +P S +L + +G + +S D
Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 1629
Query: 408 GAYTCIAKNEAGVDEDISSLFVE 430
+Y C+A+N+AG E + +L V+
Sbjct: 1630 ASYMCVAENQAGSAEKLFTLRVQ 1652
Score = 63.9 bits (154), Expect = 6e-10
Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 10/164 (6%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIIL--NNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
G LSC +G P I W+++ L L+ ++ G LY+ + G YT
Sbjct: 895 GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQEGTYT 952
Query: 320 CYADGYE-QVYQTHIFQVNVPPVI---RVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 375
C Q +V+VPP I R P + A+L C+A G P P + W +
Sbjct: 953 CECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 1012
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+G + +L QL Q G +H+ + TG Y+C+A+N AG
Sbjct: 1013 DGQPVGAELGLQL--QNQGQSLHVERAQAAHTGRYSCVAENLAG 1054
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/188 (27%), Positives = 81/188 (43%), Gaps = 14/188 (7%)
Query: 247 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 306
+LP D+ L + G L CA +G+ P I W N+ + E +++ +L
Sbjct: 2851 TLPGDRSLRL-----GDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQ 2901
Query: 307 ITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAREP-GVTASLRCHAE 364
V+ G Y C+A+ Q F V PV++ S EP G + L C
Sbjct: 2902 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 2961
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
G P P + W+K+G+ P L Q + I +D G Y C+A+NE GV + +
Sbjct: 2962 GDPVPDIHWIKDGL---PLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKV 3018
Query: 425 SSLFVEDS 432
L ++ +
Sbjct: 3019 VILVLQSA 3026
Score = 60.5 bits (145), Expect = 6e-09
Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 12/164 (7%)
Query: 264 SAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYAD 323
S L C G P + W + + +++ + D L I + + G+Y C A
Sbjct: 620 SVTLECLASGVPPPDVSWFKGHQPVSSW--MGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 677
Query: 324 GYEQVYQTHI-FQVNVPPVIRVYPESQAREPG-----VTASLRCHAEGIPKPQLGWLKNG 377
+ +VNVPP I + P PG L C+A G P P L WLK+G
Sbjct: 678 NVAGSTELRYGLRVNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDG 733
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
++P + L + G + +++ R D+G Y+C+A + G D
Sbjct: 734 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 777
Score = 59.3 bits (142), Expect = 1e-08
Identities = 36/119 (30%), Positives = 55/119 (46%), Gaps = 3/119 (2%)
Query: 305 LYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHA 363
L I KV G YTC A + + +V VPP I P ++A + +L C A
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 627
Query: 364 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
G+P P + W K ++ + +T+ +G + I + D G+Y C+A N AG E
Sbjct: 628 SGVPPPDVSWFKGHQPVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 684
Score = 58.5 bits (140), Expect = 2e-08
Identities = 59/235 (25%), Positives = 94/235 (40%), Gaps = 24/235 (10%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTHVGN-- 317
G L C G P + W ++ ++ L+ +DG + ++T +HVG+
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ----VQEDGQ--VLRITGSHVGDEG 194
Query: 318 -YTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLG 372
Y C A Q FQ+ V ++ ++ E V L C A G+P P +
Sbjct: 195 RYQCVAFS-PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT 253
Query: 373 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 432
W K+G + S ++ G ++ + + D G YTC A N G E + L V
Sbjct: 254 WFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV--Y 309
Query: 433 ARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDE 487
T G G YV + + +EC + H P+ L + E P AE +E
Sbjct: 310 VPPTIEGAGGRPYVVKAVAGRPV-ALECVARGHPSPT---LSWHHEGLPVAESNE 360
Score = 58.2 bits (139), Expect = 3e-08
Identities = 47/193 (24%), Positives = 80/193 (41%), Gaps = 17/193 (8%)
Query: 243 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN----------NLD 292
V+ S+ ED + + + GQS L C G P I+W ++ ++ +L
Sbjct: 14 VVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLG 73
Query: 293 LEDINDFG--DDG-SLYITKVTTTHVGNYTCYADGYEQVYQT--HIFQVNVPPVIRVYPE 347
+ D+G SL+ ++ G Y+C A+ Q H+ + P V+
Sbjct: 74 WGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA 133
Query: 348 SQARE-PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYED 406
+ G L+C G+P PQ+ W K+ + P L +Q +G + I+ D
Sbjct: 134 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQVLRITGSHVGD 192
Query: 407 TGAYTCIAKNEAG 419
G Y C+A + AG
Sbjct: 193 EGRYQCVAFSPAG 205
Score = 57.8 bits (138), Expect = 4e-08
Identities = 55/215 (25%), Positives = 82/215 (38%), Gaps = 24/215 (11%)
Query: 233 ALEEFYRAFQVIQLSLP------EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNI 286
A+ E + FQ+ L P ED TV L C P I W ++
Sbjct: 1239 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1298
Query: 287 ILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRV 344
+I L I G YTC E V H+ +V +PP I
Sbjct: 1299 PFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHV-EVLIPPSIS- 1354
Query: 345 YPESQAREPGV---------TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 395
+ E GV T +L C + +P P + W K+G +TP S +L + G
Sbjct: 1355 -KDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGR 1411
Query: 396 EVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ I + D+G Y C+A N AG D+ ++ ++
Sbjct: 1412 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 1446
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/165 (29%), Positives = 69/165 (41%), Gaps = 20/165 (12%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G L C +G P + W ++ L + LE SL + V G Y+C
Sbjct: 2139 GSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ------GPSLQLEAVGAGDSGTYSCV 2192
Query: 322 ADGYEQVYQTHIFQVNV--PPVIRV--YPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 377
A + H FQ+ V PP I P + PG L C A+G P+P + W K+G
Sbjct: 2193 AVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2251
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+T L+ N + VR D G YTC+A++ AG E
Sbjct: 2252 QALT-------RLENNSRATRVLRVR--DAGLYTCLAESPAGAIE 2287
Score = 57.8 bits (138), Expect = 4e-08
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 3/161 (1%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
+V Q+A+L C G P + W+++ + L+ + +GSL I V G+Y
Sbjct: 2403 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRF--EILPEGSLRIQPVLAQDAGHYL 2460
Query: 320 CYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
C A Q +V PP I P + A L C A G PKP + W K+G
Sbjct: 2461 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQ 2520
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ +L + + + ++ +D+ + C+ NE G
Sbjct: 2521 KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 2561
Score = 56.6 bits (135), Expect = 9e-08
Identities = 38/157 (24%), Positives = 68/157 (43%), Gaps = 3/157 (1%)
Query: 267 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGY 325
L+C G P ++W ++ ++ + F L + + G Y+C A
Sbjct: 715 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 774
Query: 326 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 385
+ Q + QV++PP I + + + +L C + +P P L W K+G + P+
Sbjct: 775 GEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 834
Query: 386 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
L+ A+ + + + D G YTC A N+AG E
Sbjct: 835 VHLS--ADKALLQVDRADVWDAGHYTCEALNQAGHSE 869
Score = 55.8 bits (133), Expect = 2e-07
Identities = 47/169 (27%), Positives = 69/169 (40%), Gaps = 11/169 (6%)
Query: 256 ITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LYITKVTTTH 314
+ A G+ L C +G P + W + + + + DGS L +
Sbjct: 323 VVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET---DGSVLRLESPGEAS 379
Query: 315 VGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPE--SQAREPGVTASLRCHAEGIPKPQ 370
G Y+C A E V Q + +V VPP + V G L C A G P P
Sbjct: 380 SGLYSCVASSPAGEAVLQYSV-EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT 438
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ WL+NG Q+ Q G+ +HI +V + +G + C A NEAG
Sbjct: 439 IQWLQNGRPAEELAGVQVASQ--GTTLHIDHVELDHSGLFACQATNEAG 485
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/173 (24%), Positives = 67/173 (38%), Gaps = 6/173 (3%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 308
P L++TA T A+L C G+ +P ++W ++ L+ + +L +T
Sbjct: 2486 PSPSNLTLTAHT---PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLT 2542
Query: 309 KVTTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 367
+ C + ++ + V+VPP I L CH+ GIP
Sbjct: 2543 APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIP 2602
Query: 368 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 420
P + W K G + + S + E I G YTC A+N AGV
Sbjct: 2603 APTVSWSKAGAQLGARGSGYRVSPSGALE--IGQALPIHAGRYTCSARNSAGV 2653
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 8/183 (4%)
Query: 251 DQKLSITAATVGQSAVLS--CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 308
D + + TV S+ +S C G P I W +N + + + + G L ++
Sbjct: 1565 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVS 1622
Query: 309 KVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREP-GVTASLRCHAEGI 366
+Y C A+ + +V VPP I Q + SL C
Sbjct: 1623 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAH 1682
Query: 367 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISS 426
P P++ W K+ ++ L +++ L + + R D+G YTC A N AG D+ +
Sbjct: 1683 PNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1740
Query: 427 LFV 429
L V
Sbjct: 1741 LSV 1743
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 9/171 (5%)
Query: 254 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 313
L A + S L C + P + W +++ L+ E++ +L + + +
Sbjct: 1662 LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLS 1719
Query: 314 HVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYP----ESQAREPGVTASLRCHAEGIPK 368
G YTC A Q + V VPP R P ++ G A L C + +P+
Sbjct: 1720 DSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1779
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
P + W K+G + L+++ G + I + D G Y+C N AG
Sbjct: 1780 PTVTWYKDGQPLV--LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 1828
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 16/164 (9%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
T G L C QGT +P I W ++ L L ++ S + G YT
Sbjct: 2226 TPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGLYT 2276
Query: 320 CYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS---LRCHAEGIPKPQLGWLK 375
C A+ + ++ +V PP I V P G+ L C E P P++ W +
Sbjct: 2277 CLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 2335
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+GI + Q G + + + D+G Y+C A+N AG
Sbjct: 2336 DGIVLQEDAHTQ--FPERGRFLQLQALSTADSGDYSCTARNAAG 2377
Score = 47.8 bits (112), Expect = 4e-05
Identities = 50/189 (26%), Positives = 76/189 (40%), Gaps = 13/189 (6%)
Query: 239 RAFQVIQLSLPE-----DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDL 293
R F++ L PE D +ITAA + L C G P I W R ++
Sbjct: 1058 RKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PG 1114
Query: 294 EDINDFGDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE 352
ED L +T+ G Y+C A + + +V VPP I + +
Sbjct: 1115 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 1174
Query: 353 --PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 410
G TA L C+ G P+P+L W K+G + + ++ +G + + G Y
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHY 1232
Query: 411 TCIAKNEAG 419
+CIA N G
Sbjct: 1233 SCIAANAVG 1241
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/186 (23%), Positives = 75/186 (40%), Gaps = 16/186 (8%)
Query: 243 VIQLSLP-----EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN 297
V+Q+ +P E+ +S+ A +S L C P + W ++ L ++
Sbjct: 782 VLQVHMPPSILGEELNVSVVA---NESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVH 836
Query: 298 DFGDDGSLYITKVTTTHVGNYTC----YADGYEQVYQTHIFQVNVPPVIRVYPESQAREP 353
D L + + G+YTC A E+ Y +++ V P +R RE
Sbjct: 837 LSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-LRESHTLTVRE- 894
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
G L C G+P P++ W K+G + + + + A G +++ + G YTC
Sbjct: 895 GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 954
Query: 414 AKNEAG 419
N G
Sbjct: 955 CSNVVG 960
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor
[Homo sapiens]
Length = 1070
Score = 79.0 bits (193), Expect = 2e-14
Identities = 59/174 (33%), Positives = 87/174 (50%), Gaps = 13/174 (7%)
Query: 263 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD--GSLYITKVTTTHVGNYTC 320
+ A + C+ G +P I W+R D + ++ D G+L+ +VT GNYTC
Sbjct: 518 KEATVPCSATGREKPTIKWER-------ADGSSLPEWVTDNAGTLHFARVTRDDAGNYTC 570
Query: 321 YA-DGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL-KNG 377
A +G + + H+ V V +V PE G TA L+C A+G PKP + W K+
Sbjct: 571 IASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDR 630
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
I KL ++ + NGS V I +V ED+G YTCIA N + + L+V D
Sbjct: 631 ILDPTKLGPRMHIFQNGSLV-IHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVD 683
Score = 51.2 bits (121), Expect = 4e-06
Identities = 51/233 (21%), Positives = 96/233 (41%), Gaps = 25/233 (10%)
Query: 259 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-FGDDGSLYITKVTTTH-VG 316
A G+ A+L C ++ + W +L+ ++D F SL V G
Sbjct: 43 ALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG 97
Query: 317 NYTCYA-------DGYEQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPK 368
+ C A + +I + PV+ +P S+A +P +LRCH +G P+
Sbjct: 98 TFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPR 157
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN---EAGVDEDIS 425
P W ++G ++ S T+ + + + E +G Y+C A + +A ++ +
Sbjct: 158 PTYQWFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFT 216
Query: 426 SLFVEDSARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDE 478
++S + L ++ YE+ + C+F PS + L F+DE
Sbjct: 217 LSIADESFARVVLAPQDVVVARYEEAM-----FHCQFSAQPPPSLQWL-FEDE 263
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/178 (24%), Positives = 70/178 (39%), Gaps = 25/178 (14%)
Query: 246 LSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSL 305
L P+D +L G+ L C Q T +P ++W RN ++++ + + +G+L
Sbjct: 415 LKKPQDSQLE-----EGKPGYLDCLTQATPKPTVVWYRNQMLISE---DSRFEVFKNGTL 466
Query: 306 YITKVTTTHVGNYTCYA-------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS 358
I V Y C + + +V + PP Q E A+
Sbjct: 467 RINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPP-----QPQQCMEFDKEAT 521
Query: 359 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 416
+ C A G KP + W + P+ + N +H + V +D G YTCIA N
Sbjct: 522 VPCSATGREKPTIKWERADGSSLPE-----WVTDNAGTLHFARVTRDDAGNYTCIASN 574
Score = 44.7 bits (104), Expect = 4e-04
Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 12/123 (9%)
Query: 302 DGSLYITKVTTTHVGNYTCYADGYEQV-----YQTHIFQVNVPPVIRVYPESQAREPGVT 356
+GSL +T+V + G Y C G H+ ++ P+ + E VT
Sbjct: 283 NGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
Query: 357 ASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 416
+G+P+P + W G+ +L + G E+ ++N+ D G YTC A N
Sbjct: 343 C---LPPKGLPEPSVWWEHAGV----RLPTHGRVYQKGHELVLANIAESDAGVYTCHAAN 395
Query: 417 EAG 419
AG
Sbjct: 396 LAG 398
Score = 39.7 bits (91), Expect = 0.012
Identities = 24/66 (36%), Positives = 30/66 (45%)
Query: 257 TAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVG 316
T G +A+L C QG +P I WK + IL+ L +GSL I V G
Sbjct: 601 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660
Query: 317 NYTCYA 322
YTC A
Sbjct: 661 RYTCIA 666
Score = 32.7 bits (73), Expect = 1.4
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 5/78 (6%)
Query: 346 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNV-RY 404
P SQ G A LRC E + WL +G + + A GS + + V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 405 EDTGAYTCIAKNEAGVDE 422
+D+G + C+A+++ +E
Sbjct: 94 QDSGTFQCVARDDVTGEE 111
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
[Homo sapiens]
Length = 1030
Score = 76.6 bits (187), Expect = 9e-14
Identities = 66/235 (28%), Positives = 99/235 (42%), Gaps = 55/235 (23%)
Query: 246 LSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNN--------------- 290
L P+D +L G+ L C Q T +P ++W RN ++++
Sbjct: 415 LKKPQDSQLE-----EGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRIN 469
Query: 291 -----------------------------LDLEDINDFGDD--GSLYITKVTTTHVGNYT 319
LD + ++ D G+L+ +VT GNYT
Sbjct: 470 SVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYT 529
Query: 320 CYA-DGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL-KN 376
C A +G + + H+ V V +V PE G TA L+C A+G PKP + W K+
Sbjct: 530 CIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKD 589
Query: 377 GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
I KL ++ + NGS V I +V ED+G YTCIA N + + L+V D
Sbjct: 590 RILDPTKLGPRMHIFQNGSLV-IHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVD 643
Score = 51.2 bits (121), Expect = 4e-06
Identities = 51/233 (21%), Positives = 96/233 (41%), Gaps = 25/233 (10%)
Query: 259 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-FGDDGSLYITKVTTTH-VG 316
A G+ A+L C ++ + W +L+ ++D F SL V G
Sbjct: 43 ALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG 97
Query: 317 NYTCYA-------DGYEQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPK 368
+ C A + +I + PV+ +P S+A +P +LRCH +G P+
Sbjct: 98 TFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPR 157
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN---EAGVDEDIS 425
P W ++G ++ S T+ + + + E +G Y+C A + +A ++ +
Sbjct: 158 PTYQWFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFT 216
Query: 426 SLFVEDSARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDE 478
++S + L ++ YE+ + C+F PS + L F+DE
Sbjct: 217 LSIADESFARVVLAPQDVVVARYEEAM-----FHCQFSAQPPPSLQWL-FEDE 263
Score = 44.7 bits (104), Expect = 4e-04
Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 12/123 (9%)
Query: 302 DGSLYITKVTTTHVGNYTCYADGYEQV-----YQTHIFQVNVPPVIRVYPESQAREPGVT 356
+GSL +T+V + G Y C G H+ ++ P+ + E VT
Sbjct: 283 NGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
Query: 357 ASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 416
+G+P+P + W G+ +L + G E+ ++N+ D G YTC A N
Sbjct: 343 C---LPPKGLPEPSVWWEHAGV----RLPTHGRVYQKGHELVLANIAESDAGVYTCHAAN 395
Query: 417 EAG 419
AG
Sbjct: 396 LAG 398
Score = 39.7 bits (91), Expect = 0.012
Identities = 33/131 (25%), Positives = 59/131 (45%), Gaps = 6/131 (4%)
Query: 305 LYITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCH 362
L + + + G YTC+A ++ +I VP ++ +SQ E G L C
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEE-GKPGYLDCL 434
Query: 363 AEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ PKP + W +N + I+ + + NG+ + I++V D Y C++ AG E
Sbjct: 435 TQATPKPTVVWYRNQMLISE--DSRFEVFKNGT-LRINSVEVYDGTWYRCMSSTPAGSIE 491
Query: 423 DISSLFVEDSA 433
+ + V D +
Sbjct: 492 AQARVQVLDGS 502
Score = 32.7 bits (73), Expect = 1.4
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 5/78 (6%)
Query: 346 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNV-RY 404
P SQ G A LRC E + WL +G + + A GS + + V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 405 EDTGAYTCIAKNEAGVDE 422
+D+G + C+A+++ +E
Sbjct: 94 QDSGTFQCVARDDVTGEE 111
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 75.9 bits (185), Expect = 1e-13
Identities = 54/179 (30%), Positives = 83/179 (46%), Gaps = 12/179 (6%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDIND------FGDDGSLYITKVTTT 313
G+ + C G+ P I W +I N + +D ++G+LY KV
Sbjct: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
Query: 314 HVGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPKPQ 370
G+YTCYA + + H+ + P IR ++ R + G TA L C G PKP+
Sbjct: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPK 2172
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
+ WL D+ + T ANGS + I+ V+ D+G Y C+A+N +G D + L V
Sbjct: 2173 IFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
Score = 67.8 bits (164), Expect = 4e-11
Identities = 56/187 (29%), Positives = 91/187 (48%), Gaps = 19/187 (10%)
Query: 262 GQSAVLSCAIQGTLRPPIIW--KRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
G +AVL C + G +P I W N++I ++D F +GSL I KV G Y
Sbjct: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYT---FHANGSLTINKVKLLDSGEYV 2212
Query: 320 CYADGYE----QVYQTHIFQVNVPPVIRVYPESQA--REPGVTASLR---CHAEGIPKPQ 370
C A ++Y+ + V+ PP+I ++ + V S + C AEG P P+
Sbjct: 2213 CVARNPSGDDTKMYKLDV--VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
Query: 371 LGWLK-NGIDIT-PKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
+ W+ + I +T P ++T+ NG+ + I NVR D+ + C+A+NE G + L
Sbjct: 2271 VMWIMPDNIFLTAPYYGSRITVHKNGT-LEIRNVRLSDSADFICVARNEGGESVLVVQLE 2329
Query: 429 VEDSARK 435
V + R+
Sbjct: 2330 VLEMLRR 2336
Score = 67.4 bits (163), Expect = 5e-11
Identities = 53/168 (31%), Positives = 79/168 (47%), Gaps = 10/168 (5%)
Query: 259 ATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
A +G+S L+C++ G P IIW N +N +GS I+K T G
Sbjct: 2349 AQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGK 2408
Query: 318 YTCYAD---GYEQVYQTHIFQVNVPPVIRVY-PESQAREPGVTASLRCHAEGIPKPQLGW 373
Y C A GY + + I ++ PVI Y P + G + SL C ++GIPKP + W
Sbjct: 2409 YRCAARNKVGY--IEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW 2466
Query: 374 -LKNGIDI-TPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ +G + P+++ + L NG+ V I D G Y C A+N G
Sbjct: 2467 TMPSGYVVDRPQINGKYILHDNGTLV-IKEATAYDRGNYICKAQNSVG 2513
Score = 63.9 bits (154), Expect = 6e-10
Identities = 53/188 (28%), Positives = 88/188 (46%), Gaps = 25/188 (13%)
Query: 251 DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG------DDGS 304
+Q+ + T G+S L C +GT +P + W ++ + +++ + +G+
Sbjct: 1846 EQRRQVIVGTWGESLKLPCTAKGTPQPSVYW----VLSDGTEVKPLQFTNSKLFLFSNGT 1901
Query: 305 LYITKVTTTHVGNYTCYA---DGYEQ--VYQTHIFQVNVPPVIRVYPESQAREP---GVT 356
LYI + ++ G Y C A G E+ V T +V P R+ SQ R G
Sbjct: 1902 LYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP---RIEAASQKRTEVNFGDK 1958
Query: 357 ASLRCHAEGIPKPQLGW---LKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
L C A G PKPQ+ W K +D ++ + + NGS + I +V +D+G Y C+
Sbjct: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS-LFIGSVTEKDSGVYLCV 2017
Query: 414 AKNEAGVD 421
A+N+ G D
Sbjct: 2018 ARNKMGDD 2025
Score = 63.5 bits (153), Expect = 8e-10
Identities = 53/174 (30%), Positives = 72/174 (41%), Gaps = 20/174 (11%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKR-NNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
G+S L C G +P I W + +++ + D+G+L I + T GNY C
Sbjct: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYIC 2506
Query: 321 YADGYEQVYQTHIFQVNVPPVIRVYPESQAREP--------GVTASLRCHAEGIPKPQLG 372
A V T I VP +I YP P G L C A G+PKP++
Sbjct: 2507 KAQN--SVGHTLI---TVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT 2561
Query: 373 WLKNGIDITPKLSKQLT-----LQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
W + SK+ T L G+ V I N + D+G Y C AKN G D
Sbjct: 2562 WEMPDHSLLSTASKERTHGSEQLHLQGTLV-IQNPQTSDSGIYKCTAKNPLGSD 2614
Score = 57.8 bits (138), Expect = 4e-08
Identities = 52/194 (26%), Positives = 84/194 (43%), Gaps = 27/194 (13%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGD-------DGSLYITKVTTTH 314
G + L C +G P + W IL N + + G DG+L + ++
Sbjct: 1760 GSTVELKCRAEGRPSPTVTW-----ILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYD 1814
Query: 315 VGNYTCYAD--GYEQVYQTHIFQVNVPPVIRVYPESQAREP-----GVTASLRCHAEGIP 367
G Y C A G + I + PPVI Q R+ G + L C A+G P
Sbjct: 1815 RGFYKCVASNPGGQDSLLVKIQVIAAPPVIL----EQRRQVIVGTWGESLKLPCTAKGTP 1870
Query: 368 KPQLGW-LKNGIDITPK--LSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
+P + W L +G ++ P + +L L +NG+ ++I N+ D G Y CIA + G + +
Sbjct: 1871 QPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT-LYIRNLASSDRGTYECIATSSTGSERRV 1929
Query: 425 SSLFVEDSARKTRL 438
L +E+ R+
Sbjct: 1930 VMLTMEERVTSPRI 1943
Score = 56.6 bits (135), Expect = 9e-08
Identities = 49/187 (26%), Positives = 77/187 (41%), Gaps = 18/187 (9%)
Query: 246 LSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSL 305
+S + KL T VG + L+C QG P + W +L + +DG +
Sbjct: 475 ISRDNNTKLEHTVL-VGGTVGLNCPGQGDPTPHVDW-----LLADGSKVRAPYVSEDGRI 528
Query: 306 YITK--------VTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREP---G 354
I K + G Y C + Y+ V P++ Y E+ G
Sbjct: 529 LIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIG 588
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
T L CH+ GIP + W+ G ++ + S+ + NG+ + I V +D G Y C+A
Sbjct: 589 ETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVA 647
Query: 415 KNEAGVD 421
N +GVD
Sbjct: 648 ANPSGVD 654
Score = 54.3 bits (129), Expect = 5e-07
Identities = 47/164 (28%), Positives = 74/164 (45%), Gaps = 9/164 (5%)
Query: 269 CAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA--DGY 325
C +GT P ++W +NI L +G+L I V + ++ C A +G
Sbjct: 2261 CRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGG 2320
Query: 326 EQVY--QTHIFQVNVPPVIR-VYPESQAREPGVTASLRCHAEGIPKPQLGW-LKNGIDIT 381
E V Q + ++ P R + E + G + +L C +G P P++ W L NG +
Sbjct: 2321 ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS 2380
Query: 382 P-KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
S Q + +NGS + IS ED G Y C A+N+ G E +
Sbjct: 2381 NGPQSYQYLIASNGSFI-ISKTTREDAGKYRCAARNKVGYIEKL 2423
Score = 49.7 bits (117), Expect = 1e-05
Identities = 51/196 (26%), Positives = 83/196 (42%), Gaps = 17/196 (8%)
Query: 257 TAATVGQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTH 314
T G +L+C+ G +P I+W+ + ++ + +GSL+I VT
Sbjct: 1951 TEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEKD 2010
Query: 315 VGNYTCYADGY--EQVYQTHIFQVNVPPVI--RVYPESQAREPGVTASLRCHAEGIPKPQ 370
G Y C A + + H+ P I + Y Q G + C A G P P+
Sbjct: 2011 SGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH-GKDFQVDCKASGSPVPE 2069
Query: 371 LGW-LKNGIDITPKL--------SKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
+ W L +G I + +++ TL NG+ ++ + V + G YTC A+N G D
Sbjct: 2070 ISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGT-LYFNKVGVAEEGDYTCYAQNTLGKD 2128
Query: 422 EDISSLFVEDSARKTR 437
E L V +A + R
Sbjct: 2129 EMKVHLTVITAAPRIR 2144
Score = 37.7 bits (86), Expect = 0.045
Identities = 23/68 (33%), Positives = 36/68 (52%), Gaps = 4/68 (5%)
Query: 357 ASLRCHAEGIPKPQLGWLK--NGIDITP-KLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
A L C A G P P + W + +G+D++ K + ++ + NG+ + I V +D G Y C
Sbjct: 1666 AFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGT-LSIQRVEIQDRGQYLCS 1724
Query: 414 AKNEAGVD 421
A N G D
Sbjct: 1725 ASNLFGTD 1732
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 75.5 bits (184), Expect = 2e-13
Identities = 50/176 (28%), Positives = 81/176 (46%), Gaps = 13/176 (7%)
Query: 257 TAATVGQSAVLSCAIQGTLRPPII--WKRNNIILNNLDLED-INDFGDDGS-------LY 306
T A VG+ +C+ + P+ WK++N +L N D+E+ ++ DG L+
Sbjct: 504 TMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILH 563
Query: 307 ITKVTTTHVGNYTCYADGYEQVYQTHIFQ--VNVPPVIRVYPESQAREPGVTASLRCHAE 364
+ +VT H G Y C + +H + VNV P P A L C A
Sbjct: 564 LRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAAT 623
Query: 365 GIPKPQLGWLKN-GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
G P PQ+ W K+ G D +++ + + I++V+ +D G Y+C A+N AG
Sbjct: 624 GHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAG 679
Score = 58.2 bits (139), Expect = 3e-08
Identities = 49/175 (28%), Positives = 70/175 (40%), Gaps = 12/175 (6%)
Query: 265 AVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-----FGDDGSLYITKVTTTHVGNYT 319
A L CA G P I W+++ D + DD +IT V G Y+
Sbjct: 616 ARLECAATGHPNPQIAWQKDG----GTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYS 671
Query: 320 CYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
C A + V P + V E + G T +L+C A G P P++ W K
Sbjct: 672 CTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKG-- 729
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSA 433
D L+++ L + + + NV ED G YTC N G + S L V +A
Sbjct: 730 DRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAA 784
Score = 30.0 bits (66), Expect = 9.3
Identities = 22/100 (22%), Positives = 37/100 (37%), Gaps = 9/100 (9%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
+VG++ L C G P I W + + L+ + + D+ L + V G YT
Sbjct: 705 SVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTP--DNQLLVVQNVVAEDAGRYT 762
Query: 320 CYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 359
C + H + V P + R+ G T +
Sbjct: 763 CEMSNTLGTERAH-------SQLSVLPAAGCRKDGTTVGI 795
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 75.1 bits (183), Expect = 3e-13
Identities = 58/185 (31%), Positives = 84/185 (45%), Gaps = 21/185 (11%)
Query: 257 TAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG--DDGSLYITKVTTTH 314
T T G +A+L C + G +P I WKR N IL + + I F + G L I V
Sbjct: 489 TTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVR-IPRFMLLESGGLQIAPVFIQD 547
Query: 315 VGNYTCYADGYEQVYQTHIFQVNVPPVIRVY--------PESQAREPGVTASLRCHAEGI 366
GNYTCYA E +N + V+ PE G TA+L C A
Sbjct: 548 AGNYTCYAANTEG-------SLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHD 600
Query: 367 PKPQLG--WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
P+ L W K+ + +TP + ++ ++ +GS + IS D G Y+C +E G D +
Sbjct: 601 PRVSLRYVWKKDNVALTPSSTSRIVVEKDGS-LLISQTWSGDIGDYSCEIVSEGGNDSRM 659
Query: 425 SSLFV 429
+ L V
Sbjct: 660 ARLEV 664
Score = 65.5 bits (158), Expect = 2e-10
Identities = 45/167 (26%), Positives = 73/167 (43%), Gaps = 8/167 (4%)
Query: 258 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
+A V ++ + C G P + W ++ I ++ L G L I K+ G
Sbjct: 397 SAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLAS-GGLRIQKLRPEDSGI 455
Query: 318 YTCYADGYEQVYQTHIFQ--VNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 375
+ C+A QTH + N+ PV P G+TA LRC G PKP + W +
Sbjct: 456 FQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKR 515
Query: 376 NGIDI---TPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ + ++ + + L++ G + I+ V +D G YTC A N G
Sbjct: 516 ENHILASGSVRIPRFMLLESGG--LQIAPVFIQDAGNYTCYAANTEG 560
Score = 33.9 bits (76), Expect = 0.64
Identities = 48/182 (26%), Positives = 75/182 (41%), Gaps = 32/182 (17%)
Query: 251 DQKLSITAATVGQSAVLSCA-IQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYI 307
DQ+ +++ G++A+L+ I RP + W R + II +N + + L I
Sbjct: 197 DQRKTVSQ---GRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITL-----ENQLVI 248
Query: 308 TKVTTTHVGNYTCYADGYEQ--------VYQTHIFQVNVP----PVIRVYPESQAREPGV 355
TT+ G Y A + ++ + V P P I V P +++ G
Sbjct: 249 LATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGS 308
Query: 356 T-ASLRCHAEGIPKPQLG--WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTC 412
+ +L C A P L W +NG+ IT L + G + ISN DTG Y C
Sbjct: 309 SETTLECIASARPVEDLSVTWKRNGVRITSGL------HSFGRRLTISNPTSADTGPYVC 362
Query: 413 IA 414
A
Sbjct: 363 EA 364
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 75.1 bits (183), Expect = 3e-13
Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 14/170 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDIN--DFGDDGSLYITKVTTTHVG 316
G++ C +G +P + W++ N++ N + + G L IT + + G
Sbjct: 344 GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 403
Query: 317 NYTCYAD-------GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKP 369
Y C A Q+ T + PP+I P +Q TA L+C A G P P
Sbjct: 404 YYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP 463
Query: 370 QLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ WLK G P + T+Q G+ + I N+R DTG YTC+A + +G
Sbjct: 464 VISWLKEGFTF-PGRDPRATIQEQGT-LQIKNLRISDTGTYTCVATSSSG 511
Score = 63.5 bits (153), Expect = 8e-10
Identities = 45/157 (28%), Positives = 70/157 (44%), Gaps = 10/157 (6%)
Query: 269 CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADG-YEQ 327
C +QG +P + WK+++ L D DD +L I K +T G Y C A+ +
Sbjct: 262 CQVQGDPQPTVRWKKDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK 317
Query: 328 VYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID--ITPKLS 385
+ + V PP V P Q G T + C +G P+P + W K G + P
Sbjct: 318 MEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQP 377
Query: 386 KQLTLQANGS---EVHISNVRYEDTGAYTCIAKNEAG 419
+Q + + S ++ I+N++ D G Y C A AG
Sbjct: 378 QQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 414
Score = 52.0 bits (123), Expect = 2e-06
Identities = 55/220 (25%), Positives = 88/220 (40%), Gaps = 21/220 (9%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKV-----TTTH 314
G+ L+C +G P I W ++ + + D GSL+ ++ +
Sbjct: 61 GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPD 120
Query: 315 VGNYTCYADGY--EQVYQTHIFQVNV-PPVIRVYPESQAREPGVTASLRCHA-EGIPKPQ 370
G+Y C A Y E V + +V + R P G A L C G P+P
Sbjct: 121 EGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPT 180
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV-DEDISSLFV 429
+ W K+ + I K + + G ++ ISN R D G YTC+ N G D D + L V
Sbjct: 181 IYWKKDKVRIDDKEER---ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV 237
Query: 430 EDSARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPS 469
+ R I + V E+ ++ C+ Q +P+
Sbjct: 238 FERPTFLRRPINQV--VLEEEAVE----FRCQVQGDPQPT 271
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/171 (25%), Positives = 73/171 (42%), Gaps = 10/171 (5%)
Query: 262 GQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
G+ A+L C +G P I WK++ + +++ + E I+ G G L I+ + G YTC
Sbjct: 163 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKE-ERISIRG--GKLMISNTRKSDAGMYTC 219
Query: 321 YADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
+ ++ V P P +Q RC +G P+P + W K+
Sbjct: 220 VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 279
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
D+ P+ + + + I D G Y CIA+N G E ++L V
Sbjct: 280 DL-PRGRYDI---KDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 326
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/124 (28%), Positives = 52/124 (41%), Gaps = 15/124 (12%)
Query: 303 GSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCH 362
G L +T V H GN Q + + Q + PP I +P G +L C
Sbjct: 18 GLLMMTVVFWGHQGN--------GQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCK 69
Query: 363 AEGIPKPQLGWLKNGIDI-----TPKLSKQLTLQANGSEVHISNVRYE--DTGAYTCIAK 415
AEG P P + W K+G + P+ + L + + I + R D G+Y C+A+
Sbjct: 70 AEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVAR 129
Query: 416 NEAG 419
N G
Sbjct: 130 NYLG 133
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 75.1 bits (183), Expect = 3e-13
Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 14/170 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDIN--DFGDDGSLYITKVTTTHVG 316
G++ C +G +P + W++ N++ N + + G L IT + + G
Sbjct: 328 GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 387
Query: 317 NYTCYAD-------GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKP 369
Y C A Q+ T + PP+I P +Q TA L+C A G P P
Sbjct: 388 YYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP 447
Query: 370 QLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ WLK G P + T+Q G+ + I N+R DTG YTC+A + +G
Sbjct: 448 VISWLKEGFTF-PGRDPRATIQEQGT-LQIKNLRISDTGTYTCVATSSSG 495
Score = 63.5 bits (153), Expect = 8e-10
Identities = 45/157 (28%), Positives = 70/157 (44%), Gaps = 10/157 (6%)
Query: 269 CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADG-YEQ 327
C +QG +P + WK+++ L D DD +L I K +T G Y C A+ +
Sbjct: 246 CQVQGDPQPTVRWKKDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK 301
Query: 328 VYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID--ITPKLS 385
+ + V PP V P Q G T + C +G P+P + W K G + P
Sbjct: 302 MEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQP 361
Query: 386 KQLTLQANGS---EVHISNVRYEDTGAYTCIAKNEAG 419
+Q + + S ++ I+N++ D G Y C A AG
Sbjct: 362 QQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 398
Score = 52.0 bits (123), Expect = 2e-06
Identities = 55/220 (25%), Positives = 88/220 (40%), Gaps = 21/220 (9%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKV-----TTTH 314
G+ L+C +G P I W ++ + + D GSL+ ++ +
Sbjct: 45 GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPD 104
Query: 315 VGNYTCYADGY--EQVYQTHIFQVNV-PPVIRVYPESQAREPGVTASLRCHA-EGIPKPQ 370
G+Y C A Y E V + +V + R P G A L C G P+P
Sbjct: 105 EGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPT 164
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV-DEDISSLFV 429
+ W K+ + I K + + G ++ ISN R D G YTC+ N G D D + L V
Sbjct: 165 IYWKKDKVRIDDKEER---ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV 221
Query: 430 EDSARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPS 469
+ R I + V E+ ++ C+ Q +P+
Sbjct: 222 FERPTFLRRPINQV--VLEEEAVE----FRCQVQGDPQPT 255
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/171 (25%), Positives = 73/171 (42%), Gaps = 10/171 (5%)
Query: 262 GQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
G+ A+L C +G P I WK++ + +++ + E I+ G G L I+ + G YTC
Sbjct: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKE-ERISIRG--GKLMISNTRKSDAGMYTC 203
Query: 321 YADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
+ ++ V P P +Q RC +G P+P + W K+
Sbjct: 204 VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 263
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
D+ P+ + + + I D G Y CIA+N G E ++L V
Sbjct: 264 DL-PRGRYDI---KDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/102 (28%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 325 YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI---- 380
Y +V + + Q + PP I +P G +L C AEG P P + W K+G +
Sbjct: 16 YVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDK 75
Query: 381 -TPKLSKQLTLQANGSEVHISNVRYE--DTGAYTCIAKNEAG 419
P+ + L + + I + R D G+Y C+A+N G
Sbjct: 76 DDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLG 117
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 74.3 bits (181), Expect = 4e-13
Identities = 54/166 (32%), Positives = 74/166 (44%), Gaps = 22/166 (13%)
Query: 263 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGD----DGSLYITKVTTTHVGNY 318
Q+ VL C G +P I W R LD + I+ F +G+L I+ V H G Y
Sbjct: 250 QTVVLECMATGNPKPIISWSR-------LDHKSIDVFNTRVLGNGNLMISDVRLQHAGVY 302
Query: 319 TCYAD-----GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 373
C A + T V PP +PES R TA C AEGIP P++ W
Sbjct: 303 VCRATTPGTRNFTVAMAT--LTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
Query: 374 LKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
LKNG K+ ++ S++ I+ + ED Y C+A+N G
Sbjct: 361 LKNG----RKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQG 402
Score = 40.4 bits (93), Expect = 0.007
Identities = 63/245 (25%), Positives = 95/245 (38%), Gaps = 35/245 (14%)
Query: 184 KYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADK-HLALEEFYRAFQ 242
K + SNG + I+E+ + + E+ + + C + KY + K HLAL AF+
Sbjct: 83 KRIEVLSNGSLYISEV-EGRRGEQSDEGFYQCL--AMNKYGAILSQKAHLALSTI-SAFE 138
Query: 243 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD 302
V +S T G A +C I I W+ N L + ++ I
Sbjct: 139 VQPIS---------TEVHEGGVARFACKISSHPPAVITWEFNRTTLP-MTMDRITAL-PT 187
Query: 303 GSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNV----------PPVIRVYPESQARE 352
G L I V+ GNY C A ++ + V P I P++
Sbjct: 188 GVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTS 247
Query: 353 PGVTASLRCHAEGIPKPQLGWLK---NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGA 409
T L C A G PKP + W + ID+ + NG+ + IS+VR + G
Sbjct: 248 LHQTVVLECMATGNPKPIISWSRLDHKSIDVF-----NTRVLGNGN-LMISDVRLQHAGV 301
Query: 410 YTCIA 414
Y C A
Sbjct: 302 YVCRA 306
Score = 35.4 bits (80), Expect = 0.22
Identities = 44/177 (24%), Positives = 70/177 (39%), Gaps = 17/177 (9%)
Query: 250 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN-NLDLEDINDFGDDGSLYIT 308
E Q +++T VL C G + + W +N ++ N +E +++ GSLYI+
Sbjct: 44 EPQDVTVTRK---DPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSN----GSLYIS 96
Query: 309 KVT-----TTHVGNYTCYA-DGYEQVY-QTHIFQVNVPPVIRVYPESQAREPGVTASLRC 361
+V + G Y C A + Y + Q ++ V P S G A C
Sbjct: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFAC 156
Query: 362 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 418
P + W N + P ++T G + I +V D+G Y CIA A
Sbjct: 157 KISSHPPAVITWEFNRTTL-PMTMDRITALPTGV-LQIYDVSQRDSGNYRCIAATVA 211
Score = 35.4 bits (80), Expect = 0.22
Identities = 23/66 (34%), Positives = 36/66 (54%), Gaps = 8/66 (12%)
Query: 359 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNV-----RYEDTGAYTCI 413
L C A G ++ WLKNG ++ +K++ + +NGS ++IS V D G Y C+
Sbjct: 58 LDCQAHGEVPIKVTWLKNGAKMSE--NKRIEVLSNGS-LYISEVEGRRGEQSDEGFYQCL 114
Query: 414 AKNEAG 419
A N+ G
Sbjct: 115 AMNKYG 120
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 72.8 bits (177), Expect = 1e-12
Identities = 50/132 (37%), Positives = 70/132 (53%), Gaps = 4/132 (3%)
Query: 303 GSLYITKVTTTHVGNYTCYA-DGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLR 360
G+L+ +VT GNYTC A +G + + H+ V V +V PE G TA L+
Sbjct: 423 GTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQ 482
Query: 361 CHAEGIPKPQLGWL-KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
C A+G PKP + W K+ I KL ++ + NGS V I +V ED+G YTCIA N
Sbjct: 483 CEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLV-IHDVAPEDSGRYTCIAGNSCN 541
Query: 420 VDEDISSLFVED 431
+ + L+V D
Sbjct: 542 IKHTEAPLYVVD 553
Score = 51.2 bits (121), Expect = 4e-06
Identities = 51/233 (21%), Positives = 96/233 (41%), Gaps = 25/233 (10%)
Query: 259 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-FGDDGSLYITKVTTTH-VG 316
A G+ A+L C ++ + W +L+ ++D F SL V G
Sbjct: 43 ALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG 97
Query: 317 NYTCYA-------DGYEQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPK 368
+ C A + +I + PV+ +P S+A +P +LRCH +G P+
Sbjct: 98 TFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPR 157
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN---EAGVDEDIS 425
P W ++G ++ S T+ + + + E +G Y+C A + +A ++ +
Sbjct: 158 PTYQWFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFGQACSSQNFT 216
Query: 426 SLFVEDSARKTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDE 478
++S + L ++ YE+ + C+F PS + L F+DE
Sbjct: 217 LSIADESFARVVLAPQDVVVARYEEAM-----FHCQFSAQPPPSLQWL-FEDE 263
Score = 44.7 bits (104), Expect = 4e-04
Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 12/123 (9%)
Query: 302 DGSLYITKVTTTHVGNYTCYADGYEQV-----YQTHIFQVNVPPVIRVYPESQAREPGVT 356
+GSL +T+V + G Y C G H+ ++ P+ + E VT
Sbjct: 283 NGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
Query: 357 ASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 416
+G+P+P + W G+ +L + G E+ ++N+ D G YTC A N
Sbjct: 343 C---LPPKGLPEPSVWWEHAGV----RLPTHGRVYQKGHELVLANIAESDAGVYTCHAAN 395
Query: 417 EAG 419
AG
Sbjct: 396 LAG 398
Score = 39.7 bits (91), Expect = 0.012
Identities = 24/66 (36%), Positives = 30/66 (45%)
Query: 257 TAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVG 316
T G +A+L C QG +P I WK + IL+ L +GSL I V G
Sbjct: 471 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 530
Query: 317 NYTCYA 322
YTC A
Sbjct: 531 RYTCIA 536
Score = 32.7 bits (73), Expect = 1.4
Identities = 22/78 (28%), Positives = 36/78 (46%), Gaps = 5/78 (6%)
Query: 346 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNV-RY 404
P SQ G A LRC E + WL +G + + A GS + + V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 405 EDTGAYTCIAKNEAGVDE 422
+D+G + C+A+++ +E
Sbjct: 94 QDSGTFQCVARDDVTGEE 111
Score = 30.4 bits (67), Expect = 7.1
Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 6/58 (10%)
Query: 361 CHAEGIPKPQLGWLKNGIDITPKLSKQLT--LQANGSEVHISNVRYEDTGAYTCIAKN 416
CHA + G + ++IT L + N +H + V +D G YTCIA N
Sbjct: 391 CHAANLA----GQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN 444
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 72.0 bits (175), Expect = 2e-12
Identities = 50/175 (28%), Positives = 78/175 (44%), Gaps = 6/175 (3%)
Query: 257 TAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVG 316
T VG+S L C+ G P I W R + L ++ + G LYI V G
Sbjct: 351 TEVLVGESVTLECSATGHPPPRISWTRGD--RTPLPVDPRVNITPSGGLYIQNVVQGDSG 408
Query: 317 NYTCYA-DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 375
Y C A + + V+ T V P V P+ + G T +C A+G P P + W K
Sbjct: 409 EYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK 468
Query: 376 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
G ++ + ++ + ++G+ + IS V D G Y C A N G + ++ L V+
Sbjct: 469 GGSQLS--VDRRHLVLSSGT-LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQ 520
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/165 (29%), Positives = 73/165 (44%), Gaps = 14/165 (8%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG--DDGSLYITKVTTTHVGN 317
T G + +C +G +P IIW RNN N L ++ + DDG+L I T G
Sbjct: 258 TSGNTVYFTCRAEGNPKPEIIWLRNN---NELSMKTDSRLNLLDDGTLMIQNTQETDQGI 314
Query: 318 YTCYADGYEQVYQT-----HIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLG 372
Y C A +T F P + P++ G + +L C A G P P++
Sbjct: 315 YQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRIS 374
Query: 373 WLKNGIDITP-KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 416
W + D TP + ++ + +G ++I NV D+G Y C A N
Sbjct: 375 WTRG--DRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATN 416
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/161 (27%), Positives = 70/161 (43%), Gaps = 9/161 (5%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
GQ+ C +G P I W + + L ++ + G+L I+ V G Y C
Sbjct: 447 GQTVDFQCEAKGNPPPVIAWTKGG---SQLSVDRRHLVLSSGTLRISGVALHDQGQYECQ 503
Query: 322 AD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
A G ++V Q V PV P E G L C ++G P+P + W K+G+
Sbjct: 504 AVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGV 563
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+T S + + G + I++V D G Y C+A+N G
Sbjct: 564 QVTE--SGKFHISPEGF-LTINDVGPADAGRYECVARNTIG 601
Score = 55.8 bits (133), Expect = 2e-07
Identities = 30/80 (37%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 340 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHI 399
P I P+ G T C AEG PKP++ WL+N +++ K +L L +G+ + I
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT-LMI 304
Query: 400 SNVRYEDTGAYTCIAKNEAG 419
N + D G Y C+AKN AG
Sbjct: 305 QNTQETDQGIYQCMAKNVAG 324
Score = 36.2 bits (82), Expect = 0.13
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 9/98 (9%)
Query: 247 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 306
S+P D T VG + L C+ QG P I W ++ + + I+ +G L
Sbjct: 529 SIPSD-----TTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHIS---PEGFLT 580
Query: 307 ITKVTTTHVGNYTCYA-DGYEQVYQTHIFQVNVPPVIR 343
I V G Y C A + + + VNVP V R
Sbjct: 581 INDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSR 618
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 71.6 bits (174), Expect = 3e-12
Identities = 54/183 (29%), Positives = 77/183 (42%), Gaps = 6/183 (3%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
Q+ S A G+ AVL C + G P W R ++ L + + G +L I+ VT
Sbjct: 244 QRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQ-LRSKKYSLLGGS-NLLISNVT 301
Query: 312 TTHVGNYTCYAD-GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 370
G YTC E + + V VPP +P + + C G P P
Sbjct: 302 DDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPT 361
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ W+KNG + P Q+ GS + I V D G Y C+A+NEAG + + L V
Sbjct: 362 VNWMKNGDVVIPSDYFQIV---GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVP 418
Query: 431 DSA 433
A
Sbjct: 419 KPA 421
Score = 53.9 bits (128), Expect = 6e-07
Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 21/213 (9%)
Query: 218 YVLLKYDDFNADKHLALEEFY-RAFQVIQ-LSLPEDQKLSITAATV-GQSAVLSCAIQGT 274
+VL F+A HL + F +AF ++ LS P D A T+ G + +L C+ +
Sbjct: 15 FVLFGASLFSA--HLQVTGFQIKAFTALRFLSEPSD------AVTMRGGNVLLDCSAESD 66
Query: 275 LRPPII-WKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH-----VGNYTCYA---DGY 325
P+I WK++ I L L +++ +GSL I + + G Y C A D
Sbjct: 67 RGVPVIKWKKDGIHLA-LGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSG 125
Query: 326 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 385
+ +T V P ES G T L+C G P P + W KN D+TP
Sbjct: 126 SIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPG 185
Query: 386 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 418
+ + IS ++ D G Y C A+N A
Sbjct: 186 DSRVVVLPSGALQISRLQPGDIGIYRCSARNPA 218
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 71.2 bits (173), Expect = 4e-12
Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 258 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 318 YTCYAD---GYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 373
YTC A+ G + T QV + PP V P Q G T + +C A G P+P + W
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 374 LKNGID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 RREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 303
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 321 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 304 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 354
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 433
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 415 KNEAG 419
+G
Sbjct: 492 STPSG 496
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 10/182 (5%)
Query: 252 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 311 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 429 VE 430
V+
Sbjct: 308 VQ 309
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 314
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 315 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 370
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 335 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 389
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 390 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 419
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 71.2 bits (173), Expect = 4e-12
Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 258 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 318 YTCYAD---GYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 373
YTC A+ G + T QV + PP V P Q G T + +C A G P+P + W
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 374 LKNGID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 RREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 303
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 321 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 304 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 354
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 433
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 415 KNEAG 419
+G
Sbjct: 492 STPSG 496
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 10/182 (5%)
Query: 252 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 311 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 429 VE 430
V+
Sbjct: 308 VQ 309
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 314
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 315 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 370
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 335 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 389
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 390 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 419
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 71.2 bits (173), Expect = 4e-12
Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 258 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 318 YTCYAD---GYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 373
YTC A+ G + T QV + PP V P Q G T + +C A G P+P + W
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 374 LKNGID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 RREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 303
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 321 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 304 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 354
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 433
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 415 KNEAG 419
+G
Sbjct: 492 STPSG 496
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 10/182 (5%)
Query: 252 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 311 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 429 VE 430
V+
Sbjct: 308 VQ 309
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 314
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 315 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 370
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 335 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 389
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 390 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 419
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 71.2 bits (173), Expect = 4e-12
Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 258 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 318 YTCYAD---GYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 373
YTC A+ G + T QV + PP V P Q G T + +C A G P+P + W
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 374 LKNGID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 RREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 303
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 321 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 304 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 354
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 433
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 415 KNEAG 419
+G
Sbjct: 492 STPSG 496
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 10/182 (5%)
Query: 252 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 311 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 429 VE 430
V+
Sbjct: 308 VQ 309
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 314
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 315 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 370
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 335 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 389
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 390 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 419
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 71.2 bits (173), Expect = 4e-12
Identities = 55/194 (28%), Positives = 87/194 (44%), Gaps = 14/194 (7%)
Query: 239 RAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND 298
R V+ ++ PE+ T GQS V+ C P + W R + + D+ +
Sbjct: 240 RGQDVVIVAAPEN-----TTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGR 294
Query: 299 FGDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNV--PPVIRVYPESQAREPGV 355
+L I H G Y C A+ + + T ++ V P I PE+ +R
Sbjct: 295 T----NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRAS 350
Query: 356 TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAK 415
TA C A G P+P L WL NG + P + ++ +Q G + I+ + +D G Y C+A+
Sbjct: 351 TARFVCRASGEPRPALRWLHNGAPLRP--NGRVKVQGGGGSLVITQIGLQDAGYYQCVAE 408
Query: 416 NEAGVDEDISSLFV 429
N AG+ +SL V
Sbjct: 409 NSAGMACAAASLAV 422
Score = 60.1 bits (144), Expect = 8e-09
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 24/174 (13%)
Query: 263 QSAVLSCAIQGTLRPP---IIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH----- 314
Q+AVL+C++ P + W ++ + L D +GSL++++ +
Sbjct: 51 QAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSLWLSQPLAPNGSDES 107
Query: 315 --------VGNYTCYADGYEQVY--QTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE 364
GNY+C A G V QT + ++ ++PESQ E TA CH E
Sbjct: 108 VPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIE 167
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 418
G+P P + W K+ +T +L + NG + I +V+ D G Y C+A N A
Sbjct: 168 GLPAPIITWEKD--QVTLPEEPRLIVLPNG-VLQILDVQESDAGPYRCVATNSA 218
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 70.5 bits (171), Expect = 6e-12
Identities = 51/169 (30%), Positives = 76/169 (44%), Gaps = 12/169 (7%)
Query: 258 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 318 YTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKN 376
YTC A+ + + V PP V P Q G T + +C A G P+P + W +
Sbjct: 289 YTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 348
Query: 377 GID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 GSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 396
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 303
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 318 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 304 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 354
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 430
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 431 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 488
Query: 415 KNEAG 419
+G
Sbjct: 489 STPSG 493
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 10/183 (5%)
Query: 252 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 311 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 429 VED 431
V++
Sbjct: 308 VQE 310
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 314
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 315 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 370
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 335 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 389
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 390 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 419
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 70.5 bits (171), Expect = 6e-12
Identities = 51/169 (30%), Positives = 76/169 (44%), Gaps = 12/169 (7%)
Query: 258 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 317
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 272 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 327
Query: 318 YTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKN 376
YTC A+ + + V PP V P Q G T + +C A G P+P + W +
Sbjct: 328 YTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 387
Query: 377 GID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 388 GSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 435
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 249 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 303
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 357 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 304 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 354
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 469
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 470 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 527
Query: 415 KNEAG 419
+G
Sbjct: 528 STPSG 532
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 10/183 (5%)
Query: 252 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 174 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 230
Query: 311 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 290
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 291 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 346
Query: 429 VED 431
V++
Sbjct: 347 VQE 349
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 314
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 82 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 141
Query: 315 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 370
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 142 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 201
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 422
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 202 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 250
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/145 (26%), Positives = 58/145 (40%), Gaps = 19/145 (13%)
Query: 284 NNIILNNL--DLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPV 341
N++ L L D ED+ D G+ T + YT + + Q + PP
Sbjct: 20 NHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYT----------GSRLRQEDFPPR 69
Query: 342 IRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLTLQANGSE 396
I +P G A+L C AEG P P + W K G + P+ + L +
Sbjct: 70 IVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 129
Query: 397 VHISNVRYE--DTGAYTCIAKNEAG 419
+ I + R D G Y C+A+N G
Sbjct: 130 LRIVHGRKSRPDEGVYVCVARNYLG 154
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 70.5 bits (171), Expect = 6e-12
Identities = 72/296 (24%), Positives = 123/296 (41%), Gaps = 37/296 (12%)
Query: 158 KYIMQENENPNGDDISRKKLLVDQMFKYFDADSNGLVDINE--LTQVIKQEEL---GKDL 212
K I+Q N+ + I++K + + ++ D ++N ++ I E +Q +E + L
Sbjct: 390 KLILQGNQIKS---ITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLL 446
Query: 213 FDCTLYVLLKYDDFNADKH-----LALEEFYRAFQVIQLSLPE---DQKLS--------I 256
DC L LL++ N +H A E+ ++ + L + D L
Sbjct: 447 CDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPET 506
Query: 257 TAATVGQSAVLSCAIQGTLRPPI--IWKRNNIILNNLDLEDINDFGDDGS--------LY 306
A G + L+C + P+ +W++++ IL ++D E+ + L+
Sbjct: 507 IIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILH 566
Query: 307 ITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE 364
+ V T G Y C + Q VN P P G A L C AE
Sbjct: 567 LFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAE 626
Query: 365 GIPKPQLGWLKN-GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
G P PQ+ W K+ G D +++ + I+NV+ ED G Y+C+A+N AG
Sbjct: 627 GHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAG 682
Score = 51.2 bits (121), Expect = 4e-06
Identities = 45/167 (26%), Positives = 68/167 (40%), Gaps = 14/167 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-----FGDDGSLYITKVTTTHVG 316
G A L CA +G P I W+++ D + +D +I V +G
Sbjct: 616 GAMARLECAAEGHPAPQISWQKDG----GTDFPAARERRMHVMPEDDVFFIANVKIEDMG 671
Query: 317 NYTCYADGYEQVYQTH--IFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL 374
Y+C A + + + P IR E + G TA L+C A G P P+L W
Sbjct: 672 IYSCMAQNTAGGLSANASLTVLETPSFIRPL-EDKTVTRGETAVLQCIAGGSPAPRLNWT 730
Query: 375 KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
K+ D ++++ A + I + ED G YTCI N G +
Sbjct: 731 KD--DGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTE 775
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 70.1 bits (170), Expect = 8e-12
Identities = 48/190 (25%), Positives = 83/190 (43%), Gaps = 10/190 (5%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN---NLDLEDINDFGDDGSLYIT 308
+KL T+G C I G+ + W ++ ++L NL +++ +L I
Sbjct: 7120 RKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVA---TLQIL 7176
Query: 309 KVTTTHVGNYTCYADG----YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE 364
+ +H+G Y C A + + + VPP + P S G + + +CH
Sbjct: 7177 QTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVT 7236
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
G ++ W K+ +I P + ++TL N + + + V D G YTC A N AG D
Sbjct: 7237 GTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCS 7296
Query: 425 SSLFVEDSAR 434
+ L V++ R
Sbjct: 7297 AQLGVQEPPR 7306
Score = 68.9 bits (167), Expect = 2e-11
Identities = 75/331 (22%), Positives = 130/331 (39%), Gaps = 50/331 (15%)
Query: 251 DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
D +L+ A VG+SA C + GT + W +++ + + I+ + L + KV
Sbjct: 8156 DIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKV 8215
Query: 311 TTTHVGNYTCYADGY----EQVYQTHIFQVNVPPVI-RVYPESQAREPGVTASLRCHAEG 365
G YTCYA Q +I + +PP + E+ G + L G
Sbjct: 8216 DKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAG 8275
Query: 366 IPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDIS 425
+ W KN I+I P + ++T + N + + D G YTC N+AG S
Sbjct: 8276 SQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTS 8335
Query: 426 SLFVEDSARK-------TRLGIGNMFYVFYEDGIKVIQPIECEF---QRHIKPSEK---- 471
S+ +++ + T + + YV ++ +PI ++ R IKPS++
Sbjct: 8336 SIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFS 8395
Query: 472 ------LLGFQDEVCPKAEGDEVQRC-------VWASAVNVKDK---------------F 503
+L +D V GD V + S V +KDK
Sbjct: 8396 FASGTAVLELRD-VAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRL 8454
Query: 504 IYVAQPTLDRVLIVDVQSQKVVQAVSTDPVP 534
+V++P + +V+ + + V DP+P
Sbjct: 8455 FFVSEP--QSIRVVEKTTATFIAKVGGDPIP 8483
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/197 (23%), Positives = 83/197 (42%), Gaps = 6/197 (3%)
Query: 241 FQVIQLSLPED--QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND 298
F++ + LP ++L TVG L+C + G+ + W R+ ++L + + +
Sbjct: 6166 FRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSF 6225
Query: 299 FGDDGSLYITKVTTTHVGNYTCYADG----YEQVYQTHIFQVNVPPVIRVYPESQAREPG 354
+ +L I + +H G Y+C A + + P + P S G
Sbjct: 6226 VDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAG 6285
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
+A CH G ++ W K+ +I P + +T N + I V D+G YTC A
Sbjct: 6286 ESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQA 6345
Query: 415 KNEAGVDEDISSLFVED 431
N+ G D + L V++
Sbjct: 6346 TNDVGKDMCSAQLSVKE 6362
Score = 64.7 bits (156), Expect = 3e-10
Identities = 48/183 (26%), Positives = 75/183 (40%), Gaps = 6/183 (3%)
Query: 245 QLSLPEDQKL-----SITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 299
QLS+ E K + A G+S L C I G+ + W RN+ L+ +++
Sbjct: 6357 QLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFI 6416
Query: 300 GDDGSLYITKVTTTHVGNYTCYA-DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS 358
L I + + G+Y C A +G + V PPV P G
Sbjct: 6417 NSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVI 6476
Query: 359 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 418
L+C G P ++ W+K+ + ++T + + +HI N+ D G Y C A NE
Sbjct: 6477 LQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEV 6536
Query: 419 GVD 421
G D
Sbjct: 6537 GSD 6539
Score = 64.3 bits (155), Expect = 4e-10
Identities = 51/184 (27%), Positives = 80/184 (43%), Gaps = 6/184 (3%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKV 310
+KLS + VG+ L I+G ++W K I+ D I+ + +L ++V
Sbjct: 7496 KKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRV 7555
Query: 311 TTTHVGNYTCYAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 367
+ G YTC G ++ + T V P I PES G T +L C G P
Sbjct: 7556 EPANAGKYTCQIKNDAGMQECFAT--LSVLEPATIVEKPESIKVTTGDTCTLECTVAGTP 7613
Query: 368 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSL 427
+ W K+G ++T +++ S + I NV D+G Y+ +N G D +SL
Sbjct: 7614 ELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASL 7673
Query: 428 FVED 431
V D
Sbjct: 7674 QVSD 7677
Score = 63.2 bits (152), Expect = 1e-09
Identities = 46/172 (26%), Positives = 76/172 (44%), Gaps = 7/172 (4%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
+K+ T + SA + G+ I W +++ IL+ D I+ +L I V
Sbjct: 5052 KKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVD 5111
Query: 312 TTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTA----SLRCHAEGIP 367
H G YTC A V + + F + P V +A+ VT +L C G P
Sbjct: 5112 NGHSGRYTCQAKNESGVERCYAFLLVQEPAQIV---EKAKSVDVTEKDPMTLECVVAGTP 5168
Query: 368 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ ++ WLK+G I P ++ + N + I +V +D+G YT +N+ G
Sbjct: 5169 ELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFG 5220
Score = 60.1 bits (144), Expect = 8e-09
Identities = 45/185 (24%), Positives = 89/185 (48%), Gaps = 5/185 (2%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN-NIILNNLDLEDINDFGDDG-SLYITK 309
+KL A +G S VL C + G+ + W ++ N I++ + + F ++ +L ++
Sbjct: 6745 RKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQ--SSFSENVCTLNLSL 6802
Query: 310 VTTTHVGNYTCYADGYEQVYQ-THIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ + G YTC A + + + V PP P+S PG++ + G P
Sbjct: 6803 LEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPP 6862
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
++ W K ++ P S ++L+ +E+ + V+ ++G Y+C+ N+AG + LF
Sbjct: 6863 FKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLF 6922
Query: 429 VEDSA 433
V++ A
Sbjct: 6923 VKEPA 6927
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/180 (26%), Positives = 76/180 (42%), Gaps = 6/180 (3%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC- 320
G + L QG+ I W + N L + I + SL + V T+ G YTC
Sbjct: 4220 GSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCK 4279
Query: 321 ---YADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 377
A G E ++F + SQ + G L C G P ++ W N
Sbjct: 4280 VSNVAGGVE--CSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFAND 4337
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTR 437
+I +++ + + + +++V ED+G Y C A+NEAG D S + V++S T+
Sbjct: 4338 REIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKESPYFTK 4397
Score = 59.3 bits (142), Expect = 1e-08
Identities = 47/183 (25%), Positives = 71/183 (38%), Gaps = 3/183 (1%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
+K+ +G A +C IQ W + + D I SL I +
Sbjct: 3460 RKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQ 3519
Query: 312 TTHVGNYTCYADG-YEQVYQTHIFQVN--VPPVIRVYPESQAREPGVTASLRCHAEGIPK 368
G YTC A Y V T V PP P+S G A C G P
Sbjct: 3520 VVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPV 3579
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
+ W K+G ++P + +++ N + +SN+ +D G Y+C A N+ G D + L
Sbjct: 3580 IETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELI 3639
Query: 429 VED 431
+ D
Sbjct: 3640 IID 3642
Score = 59.3 bits (142), Expect = 1e-08
Identities = 64/270 (23%), Positives = 111/270 (41%), Gaps = 26/270 (9%)
Query: 170 DDISRKKLLVDQMFKYFDADSNGLVDINE-LTQVIKQEELGKDLFDCTLYVLLKYDDFN- 227
++IS+K L +++ K +A S + + E ++V+ EE+ K +L + +++
Sbjct: 32970 EEISQKALRSEEI-KMSEAKSQEKLALKEEASKVLISEEVKKSAAT-SLEKSIVHEEITK 33027
Query: 228 ---ADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN 284
A + + +AF Q+S+ E Q+L + A G + V W N
Sbjct: 33028 TSQASEEVRTHAEIKAFST-QMSINEGQRLVLKANIAGATDVK-------------WVLN 33073
Query: 285 NIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQ-----THIFQVNVP 339
+ L N + G D +L I + + G TC + E + + T +++
Sbjct: 33074 GVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDA 33133
Query: 340 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHI 399
P P SQ G C G P P++ W KN + I+ + ++ N + I
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEI 33193
Query: 400 SNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
N D+G YT AKN G +SL V
Sbjct: 33194 RNASVSDSGKYTIKAKNFRGQCSATASLMV 33223
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/176 (26%), Positives = 74/176 (42%), Gaps = 1/176 (0%)
Query: 259 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNY 318
+ V + L C I G+L + W ++ + D I SL I +V GN+
Sbjct: 4124 SVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNF 4183
Query: 319 TCYA-DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 377
TC A + + V PP P S+ PG L+ +G + W K
Sbjct: 4184 TCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGN 4243
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSA 433
++ S +T +A S + + V+ D+G YTC N AG E ++LFV++ A
Sbjct: 4244 KELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPA 4299
Score = 58.9 bits (141), Expect = 2e-08
Identities = 42/175 (24%), Positives = 71/175 (40%), Gaps = 3/175 (1%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G S+ L C I G+ ++W RN L D + + + ++T G++ C
Sbjct: 5438 GDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICE 5497
Query: 322 ADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 379
A T + V PPV +P SL C G P ++ W K+
Sbjct: 5498 AQNPAGSTSCSTKVI-VKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQ 5556
Query: 380 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR 434
+ ++ + + +HI NV D G Y C A+NE G D + ++ +++ R
Sbjct: 5557 LRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPR 5611
Score = 58.5 bits (140), Expect = 2e-08
Identities = 41/185 (22%), Positives = 77/185 (41%), Gaps = 5/185 (2%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNI-ILNNLDLEDINDFGDDG-SLYITK 309
++L T +G S +L C + G+ + W I++ + F D+ +L +
Sbjct: 5804 RRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQ--TTFSDNVCTLQLNS 5861
Query: 310 VTTTHVGNYTCYADGYEQVYQTH-IFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ ++ +GNYTC A + + V PP PE PG + G P
Sbjct: 5862 LDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPP 5921
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
++ W + ++ + + +E+ + N+ +G YTC+ N AG + LF
Sbjct: 5922 FKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLF 5981
Query: 429 VEDSA 433
V++ A
Sbjct: 5982 VKEPA 5986
Score = 58.2 bits (139), Expect = 3e-08
Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 4/184 (2%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
+K TVG++ L C + GT + W ++ +L + + + SL I V
Sbjct: 5708 EKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVE 5767
Query: 312 TTHVGNYTCYA-DGYEQVYQTHIFQVN---VPPVIRVYPESQAREPGVTASLRCHAEGIP 367
G YT + + T + V+ VPP ++ G + L C G
Sbjct: 5768 RQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSS 5827
Query: 368 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSL 427
+ W I Q T N + ++++ D G YTC+A N AG DE + L
Sbjct: 5828 PISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVL 5887
Query: 428 FVED 431
V++
Sbjct: 5888 TVQE 5891
Score = 57.0 bits (136), Expect = 7e-08
Identities = 44/184 (23%), Positives = 71/184 (38%), Gaps = 20/184 (10%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
TVG V CAI G+ + W ++ L + + + +L I K + G Y+
Sbjct: 8069 TVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYS 8128
Query: 320 CYADG------------YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 367
C A + F + + PV V ES A CH G
Sbjct: 8129 CTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGES--------ADFECHVTGTQ 8180
Query: 368 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSL 427
++ W K+ +I Q++ N + + + V D+G YTC A NE G D + L
Sbjct: 8181 PIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQL 8240
Query: 428 FVED 431
+++
Sbjct: 8241 NIKE 8244
Score = 55.5 bits (132), Expect = 2e-07
Identities = 42/161 (26%), Positives = 61/161 (37%), Gaps = 5/161 (3%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
GQS C I GT + + W + + + I+ + I+ + G Y C
Sbjct: 4876 GQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCE 4935
Query: 322 ADGYEQVYQTHI-FQVNVPPVI--RVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
A I +V PP + P + V L C G P ++ WLKN
Sbjct: 4936 ARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDV--ELECEVTGTPPFEVTWLKNNR 4993
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+I LT + + +HI+ DTG Y CI NE G
Sbjct: 4994 EIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGG 5034
Score = 55.5 bits (132), Expect = 2e-07
Identities = 40/173 (23%), Positives = 72/173 (41%), Gaps = 2/173 (1%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
+G+S C + GT I W ++N + + + +L + KV G YTC
Sbjct: 7225 LGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTC 7284
Query: 321 YADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
YA + + P I+ S+ + C G P+ ++ W K+
Sbjct: 7285 YASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDET 7344
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
+I +++ + + + + N+ ED+G YTC A N AG +SL V++
Sbjct: 7345 EIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKE 7397
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/202 (24%), Positives = 82/202 (40%), Gaps = 5/202 (2%)
Query: 234 LEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDL 293
++E + V++ + ++ SI T G + L C + GT W ++ L + +
Sbjct: 7573 MQECFATLSVLEPATIVEKPESIKVTT-GDTCTLECTVAGTPELSTKWFKDGKELTSDNK 7631
Query: 294 EDINDFGDDGSLYITKVTTTHVGNYTCYADG-YEQVYQTHIFQVN---VPPVIRVYPESQ 349
I+ F L I V + G Y+ + T QV+ VPP +
Sbjct: 7632 YKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKET 7691
Query: 350 AREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGA 409
G + + C G P + W G +I+ Q TL N + ++ + D+G
Sbjct: 7692 NGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGD 7751
Query: 410 YTCIAKNEAGVDEDISSLFVED 431
YTCIA N AG DE + L V +
Sbjct: 7752 YTCIATNMAGSDECSAPLTVRE 7773
Score = 55.1 bits (131), Expect = 3e-07
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 10/217 (4%)
Query: 206 EELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSA 265
E L + DC Y +++ + A A+ LS P+ S+T VG++A
Sbjct: 3514 EILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPK----SLTTF-VGKAA 3568
Query: 266 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY 325
C + GT IW+++ L+ I+D + L ++ +T G Y+C A
Sbjct: 3569 KFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNK 3628
Query: 326 --EQVYQTHIFQVNVPPVIR-VYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP 382
+ Q + ++ P I+ + P A V L C + K + W K+G + P
Sbjct: 3629 FGADICQAELIIIDKPHFIKELEPVQSAINKKV--HLECQVDEDRKVTVTWSKDGQKLPP 3686
Query: 383 KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
++ + + + I + +D+G Y C A NEAG
Sbjct: 3687 GKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAG 3723
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/200 (22%), Positives = 82/200 (41%), Gaps = 7/200 (3%)
Query: 240 AFQVIQLSLPED--QKLSITAATVGQSAVLSCAIQGTLRPPIIW--KRNNIILNNLDLED 295
+ QV ++P +KL T G S V+ C + G+ + W + N I
Sbjct: 7672 SLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTT 7731
Query: 296 INDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPG 354
+ D + +L + + + G+YTC A + V PP P+ G
Sbjct: 7732 LTD--NTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTG 7789
Query: 355 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 414
+ +G P + W K ++ P ++L+ + +E+ + +V +G YTCI
Sbjct: 7790 TNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIV 7849
Query: 415 KNEAGVDEDISSLFVEDSAR 434
NEAG + L+++ A+
Sbjct: 7850 SNEAGKASCTTHLYIKAPAK 7869
Score = 54.3 bits (129), Expect = 5e-07
Identities = 36/167 (21%), Positives = 67/167 (40%), Gaps = 1/167 (0%)
Query: 269 CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGYEQ 327
C I G+ ++W ++ + ++ L + ++ G+YTC A +
Sbjct: 7327 CKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGS 7386
Query: 328 VYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQ 387
+ +V PP+ R P G L C +G P + W K+ ++ +
Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYK 7446
Query: 388 LTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR 434
+ + + +HI NV D G Y C A N+ G D + S+ ++ R
Sbjct: 7447 IMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPR 7493
Score = 54.3 bits (129), Expect = 5e-07
Identities = 40/161 (24%), Positives = 63/161 (39%), Gaps = 5/161 (3%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G+ +L GT + WK+N I + +I L I T G Y CY
Sbjct: 7882 GKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCY 7941
Query: 322 ---ADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
A G + + + PP E G +ASL+C G P+ + W K
Sbjct: 7942 IENASGKDSCSAQIL--ILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDT 7999
Query: 379 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ P + ++ + N + + + V D+G Y C A+N G
Sbjct: 8000 KLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVG 8040
Score = 53.1 bits (126), Expect = 1e-06
Identities = 42/193 (21%), Positives = 78/193 (40%), Gaps = 3/193 (1%)
Query: 242 QVIQLSLPED--QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 299
+V+ ++P +KL+ +G S + C + G+L W ++ ++ +
Sbjct: 5229 RVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCH 5288
Query: 300 GDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTAS 358
SL + + NYTC + I V PP V P Q P T
Sbjct: 5289 ERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVE 5348
Query: 359 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 418
+ +G P ++ W K+ +++ + L+ + S +++ +V TG YTC N+
Sbjct: 5349 FKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDV 5408
Query: 419 GVDEDISSLFVED 431
G D + L V +
Sbjct: 5409 GSDSCTTMLLVTE 5421
Score = 52.8 bits (125), Expect = 1e-06
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 4/186 (2%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
QK S A G +L C I GT ++W ++ + N I D SL+I +
Sbjct: 6462 QKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLE 6521
Query: 312 TTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPKP 369
+ VG Y C A E T V PP + G LR EG
Sbjct: 6522 ASDVGEYHCKATN-EVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPI 6580
Query: 370 QLGWLKN-GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
+ WLK+ G I + +++ N + + + + ++G Y C KN+AG+ E + L
Sbjct: 6581 SVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLT 6640
Query: 429 VEDSAR 434
V + AR
Sbjct: 6641 VLEPAR 6646
Score = 52.4 bits (124), Expect = 2e-06
Identities = 50/196 (25%), Positives = 78/196 (39%), Gaps = 10/196 (5%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDG--SLYITK 309
Q L G +A I G P + W R+ +++ L + DG L I
Sbjct: 10 QPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPA 69
Query: 310 VTTTHVGNYTCYA-DGYEQVYQTHIFQVNV---PPVIRVYPESQAREPGVTASLRCHAEG 365
VT + G Y+ A +G Q T V PP +S G L+ G
Sbjct: 70 VTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTG 129
Query: 366 IPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDIS 425
IP P + + ++G +I L Q++ + + + I+ ED+G Y+ A N G +
Sbjct: 130 IPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTA 189
Query: 426 SLFV----EDSARKTR 437
L V E A+KT+
Sbjct: 190 ELLVQGEEEVPAKKTK 205
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/170 (24%), Positives = 74/170 (43%), Gaps = 3/170 (1%)
Query: 267 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA--DG 324
L C + GT + W +NN + + + D +L+ITK + G Y C +G
Sbjct: 4974 LECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEG 5033
Query: 325 YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKL 384
T + P I+ E+ +A+ + G P + WLK+ +
Sbjct: 5034 GSCSCSTRVALKEPPSFIKKI-ENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDD 5092
Query: 385 SKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR 434
+ ++ + + + I +V +G YTC AKNE+GV+ + L V++ A+
Sbjct: 5093 NVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQ 5142
Score = 51.6 bits (122), Expect = 3e-06
Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 3/160 (1%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G+SA L C ++G+ + W +NN L+ + + + L IT V G+Y+C
Sbjct: 3752 GESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCE 3811
Query: 322 A--DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 379
A D T I P I+ + G A L+C G ++ W K+
Sbjct: 3812 AVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVR-GTNALLQCEVSGTGPFEISWFKDKKQ 3870
Query: 380 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
I +L Q + + I + D G Y C+ NE G
Sbjct: 3871 IRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910
Score = 51.6 bits (122), Expect = 3e-06
Identities = 45/175 (25%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 266 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDG--SLYITKVTTTHVGNYTCYAD 323
+L + GT I W ++N IL + F D SL I K G Y C
Sbjct: 4411 MLLAEVAGTPPFEITWFKDNTILRSG--RKYKTFIQDHLVSLQILKFVAADAGEYQCRVT 4468
Query: 324 GY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDIT 381
+ + + PP ES + G TA+ + +G + WLK+ +IT
Sbjct: 4469 NEVGSSICSARV-TLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEIT 4527
Query: 382 PKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKT 436
+ ++T + N + +++S + + G Y C AKN+AG+ + L V++ A T
Sbjct: 4528 EDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATIT 4582
Score = 51.6 bits (122), Expect = 3e-06
Identities = 39/169 (23%), Positives = 65/169 (38%), Gaps = 1/169 (0%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
++LS + G+S +L GTL + WK++ + + +I L I T
Sbjct: 5990 KRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNST 6049
Query: 312 TTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 370
G Y+C + + + PP E G + SL+C G P+
Sbjct: 6050 KRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEIT 6109
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ W K + P + N + + + V D+G YTC A+N G
Sbjct: 6110 VSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIG 6158
Score = 51.2 bits (121), Expect = 4e-06
Identities = 23/66 (34%), Positives = 34/66 (51%)
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
G + +L CH G P P + W + I + Q+T Q+ + + I ED+G +TC
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 414 AKNEAG 419
A NEAG
Sbjct: 1017 AVNEAG 1022
Score = 51.2 bits (121), Expect = 4e-06
Identities = 46/177 (25%), Positives = 68/177 (38%), Gaps = 6/177 (3%)
Query: 260 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 319
T G L C + GT W ++ L+ I SL I + G Y+
Sbjct: 6657 TTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYS 6716
Query: 320 CYADGY----EQVYQTHIFQVNVPP-VIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL 374
H+ VPP IR + A G + L C G +GW
Sbjct: 6717 FEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL-GASVVLECRVSGSAPISVGWF 6775
Query: 375 KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
++G +I Q + N +++S + DTG YTC+A N AG DE + L V++
Sbjct: 6776 QDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQE 6832
Score = 50.8 bits (120), Expect = 5e-06
Identities = 24/93 (25%), Positives = 50/93 (53%)
Query: 339 PPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVH 398
P ++ S PG +A L C +G P Q+ W KN +++ + ++ + + +
Sbjct: 3737 PSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILD 3796
Query: 399 ISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
I++V+ ED+G+Y+C A N+ G D + + +++
Sbjct: 3797 ITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKE 3829
Score = 50.4 bits (119), Expect = 7e-06
Identities = 42/194 (21%), Positives = 80/194 (41%), Gaps = 7/194 (3%)
Query: 243 VIQLSLPED--QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG 300
V+ L +P +KL + G L C + G+ I W +++ ++ + +
Sbjct: 4668 VLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHD 4727
Query: 301 DDGSLYITKVTTTHVGNYTCYAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTA 357
+ L I+++ T G YTC A G+ Q H+ V PP P+SQ P
Sbjct: 4728 NTAFLEISQLEGTDSGTYTCSATNKAGHNQC-SGHL-TVKEPPYFVEKPQSQDVNPNTRV 4785
Query: 358 SLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNE 417
L+ G + W K+ ++ ++ + + + + + D+G Y C N+
Sbjct: 4786 QLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSND 4845
Query: 418 AGVDEDISSLFVED 431
G ++LFV++
Sbjct: 4846 VGTATSKATLFVKE 4859
Score = 50.4 bits (119), Expect = 7e-06
Identities = 38/170 (22%), Positives = 68/170 (40%), Gaps = 3/170 (1%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G + + ++GT + W + + L D +++ L + V T+ G YTC
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848
Query: 322 A--DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 379
+ + TH++ + P + E G L G P + W KNGI+
Sbjct: 7849 VSNEAGKASCTTHLY-IKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGIN 7907
Query: 380 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
+TP +T + + I + ED G Y C +N +G D + + +
Sbjct: 7908 VTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILI 7957
Score = 49.3 bits (116), Expect = 1e-05
Identities = 36/169 (21%), Positives = 74/169 (43%), Gaps = 1/169 (0%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
+K+ T++ G +A ++G+L + W +++ + D + + SLY++ +
Sbjct: 4490 KKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIE 4549
Query: 312 TTHVGNYTCYADGYEQVYQ-THIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 370
H G Y C A + + + + V P I S G A+L+ G +
Sbjct: 4550 VKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEIT 4609
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
W K+G ++T ++++ S + I + +D+G YT +N+ G
Sbjct: 4610 AKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVG 4658
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/179 (22%), Positives = 80/179 (44%), Gaps = 6/179 (3%)
Query: 255 SITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH 314
+I +TV A+L +GT I W ++++ L + I G L + V +
Sbjct: 5341 AIPDSTVEFKAIL----KGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASK 5396
Query: 315 VGNYTCYA--DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLG 372
G YTC+ D T + P ++ S+ + G ++ L C G P+ ++
Sbjct: 5397 TGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVV 5456
Query: 373 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
W +N ++ ++T + + + ++N+ ED+G + C A+N AG + + V++
Sbjct: 5457 WFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKE 5515
Score = 48.5 bits (114), Expect = 3e-05
Identities = 25/102 (24%), Positives = 52/102 (50%), Gaps = 3/102 (2%)
Query: 337 NVPPVIRVYPE---SQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQAN 393
NVPP++ PE + G + ++ +G P P++ W K+G++I +++ ++T
Sbjct: 27953 NVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLG 28012
Query: 394 GSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARK 435
+ + + + + G YT AKN +G + + V+D+ K
Sbjct: 28013 STSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGK 28054
Score = 48.1 bits (113), Expect = 3e-05
Identities = 40/191 (20%), Positives = 79/191 (41%), Gaps = 13/191 (6%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
+K+ A GQ+ L A++G+ + W + ++ ++ L I V
Sbjct: 3928 KKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQ 3987
Query: 312 TTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQARE--PGVTASLRCHAEGIPKP 369
+ G YTC A+ E QT + ++ V ++ ++ + G A+L G P+
Sbjct: 3988 ISFGGKYTCLAEN-EAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPEL 4046
Query: 370 QLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG---------- 419
+ W K+G + +++ + N +++ + D+G YT NE G
Sbjct: 4047 KPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTV 4106
Query: 420 VDEDISSLFVE 430
+D DI+ F +
Sbjct: 4107 LDRDIAPFFTK 4117
Score = 47.4 bits (111), Expect = 6e-05
Identities = 40/185 (21%), Positives = 74/185 (40%), Gaps = 3/185 (1%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
++L+ + G VL GT + W ++ +++ + I L I + T
Sbjct: 6931 KRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILEST 6990
Query: 312 TTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 370
Y+C + Q + V PP E G A+L+C +G P+ +
Sbjct: 6991 IEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIR 7050
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
+ W K + + ++ + N + + I+ V + D G Y+C A N G + L ++
Sbjct: 7051 ISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIK 7110
Query: 431 DSARK 435
ARK
Sbjct: 7111 --ARK 7113
Score = 47.0 bits (110), Expect = 7e-05
Identities = 38/182 (20%), Positives = 70/182 (38%), Gaps = 2/182 (1%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKV 310
+KLS T+ +G + L ++G ++W K ++ + I+ + +L +
Sbjct: 6555 KKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSP 6614
Query: 311 TTTHVGNYTCYADGYEQVYQ-THIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKP 369
++ G Y C + + + + V P I PE G +L C G P+
Sbjct: 6615 EASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPEL 6674
Query: 370 QLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
W K+G +++ +T + + I D G Y+ KN G S+ V
Sbjct: 6675 SAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV 6734
Query: 430 ED 431
D
Sbjct: 6735 SD 6736
Score = 47.0 bits (110), Expect = 7e-05
Identities = 26/91 (28%), Positives = 39/91 (42%)
Query: 340 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHI 399
P IR + + G A L C G P P + W + G ++ +++ + +
Sbjct: 30533 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 30592
Query: 400 SNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
ED G YTCIA NE G E S L ++
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 30623
Score = 46.6 bits (109), Expect = 1e-04
Identities = 43/185 (23%), Positives = 68/185 (36%), Gaps = 6/185 (3%)
Query: 253 KLSITAATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKVT 311
KL+ G+ A L +I+G + W K ++ + I + +L K
Sbjct: 5615 KLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAE 5674
Query: 312 TTHVGNYTCYAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPK 368
+ G Y C G + T V P VI G T +L C G P+
Sbjct: 5675 PANAGKYICQIKNDGGMRENMAT--LMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPE 5732
Query: 369 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 428
+ W K+G +T + + S + I +V +D G YT +N G + +
Sbjct: 5733 LSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVD 5792
Query: 429 VEDSA 433
V D A
Sbjct: 5793 VSDRA 5797
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/115 (26%), Positives = 49/115 (42%), Gaps = 1/115 (0%)
Query: 326 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 385
E+ T + + I P S G +A C +G P P + WL+ G ++
Sbjct: 32547 EEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSAR 32606
Query: 386 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTRLGI 440
Q+T S IS+V+ D G Y+ + +N G E +L ++ AR T +
Sbjct: 32607 HQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ-KARVTEKAV 32660
Score = 44.3 bits (103), Expect = 5e-04
Identities = 44/194 (22%), Positives = 73/194 (37%), Gaps = 17/194 (8%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKV 310
Q+L G+ A I G +P I W K ++ + ++D G + +L + +
Sbjct: 3243 QELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHD-GQEYTLLLIEA 3301
Query: 311 TTTHVGNYTCYA-DGYEQVYQTHIFQVNVPPVIR------VYP-------ESQAREPGVT 356
YTC A + Y + V VP V+ VYP + G
Sbjct: 3302 FPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQP 3361
Query: 357 ASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 416
A +C G ++ W I P ++T + ++ I+ ED G YT +A N
Sbjct: 3362 ARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASN 3420
Query: 417 EAGVDEDISSLFVE 430
G ++L +E
Sbjct: 3421 AVGQVSSTANLSLE 3434
Score = 44.3 bits (103), Expect = 5e-04
Identities = 44/177 (24%), Positives = 72/177 (40%), Gaps = 7/177 (3%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G +A+L C + GT I W ++ + + + L I + VG Y C
Sbjct: 3845 GTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECV 3904
Query: 322 AD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 378
G TH+ + PP + G T +L+ G + W+K G
Sbjct: 3905 VANEVGKCGCMATHLLKE--PPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMK-GQ 3961
Query: 379 DITPKLSKQLTLQANGSEVHI-SNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR 434
++ + K +NG V I +V+ G YTC+A+NEAG + L V++ A+
Sbjct: 3962 EVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAK 4018
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 3/84 (3%)
Query: 340 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE-VH 398
P I +YPE G TA RC G P+P++ W NG I + SK+ ++ +G +
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLI--RKSKRFRVRYDGIHYLD 1898
Query: 399 ISNVRYEDTGAYTCIAKNEAGVDE 422
I + + DTG A+N GV E
Sbjct: 1899 IVDCKSYDTGEVKVTAENPEGVIE 1922
Score = 43.1 bits (100), Expect = 0.001
Identities = 49/222 (22%), Positives = 72/222 (32%), Gaps = 21/222 (9%)
Query: 254 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 313
L T + GQ A C + GT + W + + + F D L I +
Sbjct: 3351 LQDTVTSEGQPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPE 3409
Query: 314 HVGNYTCYADG--------------------YEQVYQTHIFQVNVPPVIRVYPESQAREP 353
G YT A +E++ Q ++ PVI+ E
Sbjct: 3410 DEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVAL 3469
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
G A C + P + W K G +I + S + I + D G YTC
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 3529
Query: 414 AKNEAGVDEDISSLFVEDSARKTRLGIGNMFYVFYEDGIKVI 455
A NE G ++L V ++ T L F K I
Sbjct: 3530 ASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFI 3571
Score = 42.7 bits (99), Expect = 0.001
Identities = 35/172 (20%), Positives = 60/172 (34%), Gaps = 4/172 (2%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
++L +VG SA L C + GT + W + + L ++ + +L +V
Sbjct: 7965 KQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVD 8024
Query: 312 TTHVGNYTCYADGYEQVYQTHIF----QVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 367
G Y C A+ F + +PP G+ C G
Sbjct: 8025 INDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSE 8084
Query: 368 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ W K+G + + Q + N + ++I G Y+C A N G
Sbjct: 8085 PISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIG 8136
Score = 41.2 bits (95), Expect = 0.004
Identities = 39/161 (24%), Positives = 59/161 (36%), Gaps = 1/161 (0%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G++ + I+GT + W R L D +I L + + + G YTC
Sbjct: 5907 GKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCV 5966
Query: 322 -ADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI 380
++ Q T V P + EPG + L G + W K+G +I
Sbjct: 5967 VSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNI 6026
Query: 381 TPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 421
T + + I N D G Y+C +NEAG D
Sbjct: 6027 TTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRD 6067
Score = 40.8 bits (94), Expect = 0.005
Identities = 41/175 (23%), Positives = 68/175 (38%), Gaps = 4/175 (2%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G L C +QGT + W ++ L + I S++I V +G Y C
Sbjct: 7413 GADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCK 7472
Query: 322 ADGYEQVYQTHIFQV--NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 379
A + T + + PP + G L+ EG + W K+ +
Sbjct: 7473 ATN-DVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGE 7531
Query: 380 ITPKLSK-QLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSA 433
I + ++ N + + S V + G YTC KN+AG+ E ++L V + A
Sbjct: 7532 IVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPA 7586
Score = 40.8 bits (94), Expect = 0.005
Identities = 36/162 (22%), Positives = 68/162 (41%), Gaps = 7/162 (4%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG-DDGSLYITKVTTTHVGNYTC 320
G S ++ ++ P W R N + + E+ G ++ + Y + N +
Sbjct: 19217 GGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISP 19276
Query: 321 YADGYEQVYQTHIFQVNVPPVIRVYPESQAR---EPGVTASLRCHAEGIPKPQLGWLKNG 377
++ + V I NVPP I + ++ + G L G P P + W K+G
Sbjct: 19277 PSEPSDPVT---ILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDG 19333
Query: 378 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ P ++ +Q N + + +V +D+G YT A+N +G
Sbjct: 19334 TLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSG 19375
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/189 (25%), Positives = 72/189 (38%), Gaps = 20/189 (10%)
Query: 259 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY---ITKVTTTHV 315
A VG++ I P + W ++ + D + F D LY I VTT
Sbjct: 31701 AYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDD 31760
Query: 316 GNYTCYAD---GYEQVYQTHIFQVNVPPVI--------RVYPESQAREPGVTASLRCHAE 364
YT A G + ++ PP R+ ++ +E G +
Sbjct: 31761 AEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQE-GQSVCFEIRVS 31819
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSE---VHISNVRYEDTGAYTCIAKNEAGVD 421
GIP P L W K+G ++ L + + G + +HI + EDTG Y A N AG
Sbjct: 31820 GIPPPTLKWEKDGQPLS--LGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGST 31877
Query: 422 EDISSLFVE 430
+ L VE
Sbjct: 31878 SCQAHLQVE 31886
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/178 (22%), Positives = 68/178 (38%), Gaps = 9/178 (5%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNI-ILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
GQ+A + G P W + I+N+ + + SL I T + G +T
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530
Query: 321 YADG------YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL 374
A + + V P+ ++ + G ++ A G P P + WL
Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWL 1590
Query: 375 KNGIDITPKLSKQLTLQANGSE--VHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
KN I P ++ ++ E + I + +D+ YT A N+AG D + VE
Sbjct: 1591 KNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE 1648
Score = 40.0 bits (92), Expect = 0.009
Identities = 27/140 (19%), Positives = 56/140 (40%), Gaps = 5/140 (3%)
Query: 278 PIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVN 337
P+ W ++ + D + L + ++ + G YT E + + ++
Sbjct: 2824 PVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLH 2883
Query: 338 VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEV 397
+ ++ + + TAS C P + WLKNG++I ++ +Q ++
Sbjct: 2884 ITKTMKNIEVPETK----TASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQL 2938
Query: 398 HISNVRYEDTGAYTCIAKNE 417
I N ED+ YT + N+
Sbjct: 2939 IIMNTSTEDSAEYTFVCGND 2958
Score = 39.7 bits (91), Expect = 0.012
Identities = 25/84 (29%), Positives = 34/84 (40%)
Query: 336 VNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 395
++ PVI + A A G P+P W K+G IT +L+ G
Sbjct: 32848 ISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGF 32907
Query: 396 EVHISNVRYEDTGAYTCIAKNEAG 419
+ I D+G YTC KN AG
Sbjct: 32908 FLEIHKTDTSDSGLYTCTVKNSAG 32931
Score = 39.3 bits (90), Expect = 0.015
Identities = 77/369 (20%), Positives = 137/369 (37%), Gaps = 76/369 (20%)
Query: 251 DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 310
DQ L+ + G+ LSC +QG+ I W + + D + L + V
Sbjct: 8349 DQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDV 8408
Query: 311 TTTHVGNYTCYADGY-----------------------EQVYQTHIFQVNVPPVIRVYPE 347
G+Y C A + +F V+ P IRV +
Sbjct: 8409 AKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEK 8468
Query: 348 SQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE--VHISNVRYE 405
+ TA+ G P P + W K G ++ + G E + I +
Sbjct: 8469 T-------TATFIAKVGGDPIPNVKWTK-GKWRQLNQGGRVFIHQKGDEAKLEIRDTTKT 8520
Query: 406 DTGAYTCIAKNEAGVDEDISSLFVEDSARKTRL----------------GIGNMFYVFYE 449
D+G Y C+A NE G E +L V++ ++ ++ G G +
Sbjct: 8521 DSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIM 8580
Query: 450 DGIKVIQPIECE----------FQRHIKPSEKLLGFQDEVCPKAEGDEVQRC-----VWA 494
+ +K + P E E F+ ++ E L Q+E + E +E++R +
Sbjct: 8581 ELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFE 8640
Query: 495 SAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQ-AVSTDPVPVKLHYDKSHDQVWVLSW-- 551
V+ + + +P LI D+++Q V++ + + +K++Y + LSW
Sbjct: 8641 ELVSFIQQRLSQTEPV---TLIKDIENQTVLKDNDAVFEIDIKINYPEIK-----LSWYK 8692
Query: 552 GTLEKTSPT 560
GT EK P+
Sbjct: 8693 GT-EKLEPS 8700
Score = 39.3 bits (90), Expect = 0.015
Identities = 41/164 (25%), Positives = 60/164 (36%), Gaps = 6/164 (3%)
Query: 254 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 313
L T G++A C + P+ W L D G +L + V
Sbjct: 12202 LKDVTVTAGETATFDCELSYE-DIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLE 12260
Query: 314 HVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYP-ESQAREPGVTASLRCHAEGIPKPQLG 372
G A ++ ++F V PPV P E Q E G TA L C ++
Sbjct: 12261 DAGEVQLTAKDFKT--HANLF-VKEPPVEFTKPLEDQTVEEGATAVLECEVSR-ENAKVK 12316
Query: 373 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 416
W KNG +I ++ ++ I + ED YTC AK+
Sbjct: 12317 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 12360
Score = 39.3 bits (90), Expect = 0.015
Identities = 22/96 (22%), Positives = 44/96 (45%), Gaps = 1/96 (1%)
Query: 336 VNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 395
+ + P +++ + + + G + G P+P + W+K+G + + A +
Sbjct: 24308 LTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST 24367
Query: 396 EVHISNVRYEDTGAYTCIAKNEAG-VDEDISSLFVE 430
+HI +D G YT A N AG E++S + +E
Sbjct: 24368 VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLE 24403
Score = 38.9 bits (89), Expect = 0.020
Identities = 25/93 (26%), Positives = 38/93 (40%), Gaps = 2/93 (2%)
Query: 340 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP--KLSKQLTLQANGSEV 397
P P Q G + C G PKP + W K+G+ +T + Q ++
Sbjct: 1082 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1141
Query: 398 HISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
IS +D G YT + +N+ G +SL E
Sbjct: 1142 VISMTFADDAGEYTIVVRNKHGETSASASLLEE 1174
Score = 38.9 bits (89), Expect = 0.020
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLT-LQANGSEVHISNVRYEDTGAYTC 412
G+ + C G P P++ W K+G I Q+ LQ + + I V ED G YT
Sbjct: 1305 GMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTA 1364
Query: 413 IAKNEAGVDEDISSLFVEDSA 433
A N G L+VE +A
Sbjct: 1365 FASNIKGNAICSGKLYVEPAA 1385
Score = 38.5 bits (88), Expect = 0.026
Identities = 40/156 (25%), Positives = 67/156 (42%), Gaps = 15/156 (9%)
Query: 278 PIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVN 337
P +W +N + + + I G L I +T YT + G +QV T +
Sbjct: 2911 PSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT-FVCGNDQVSAT----LT 2965
Query: 338 VPPVI--RVYPESQAREPG-VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANG 394
V P++ + + A E +T + + EGI WLKNG++I Q+ +
Sbjct: 2966 VTPIMITSMLKDINAEEKDTITFEVTVNYEGI---SYKWLKNGVEIKSTDKCQMRTKKLT 3022
Query: 395 SEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
++I NV + D YT + AG ++L+VE
Sbjct: 3023 HSLNIRNVHFGDAADYTFV----AGKATSTATLYVE 3054
Score = 38.1 bits (87), Expect = 0.034
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 7/85 (8%)
Query: 339 PPVIRVYPESQAREP----GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANG 394
PP + + + ARE G T L +G+P P++ W K D K +T G
Sbjct: 17215 PPEL-ILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVT--PVG 17271
Query: 395 SEVHISNVRYEDTGAYTCIAKNEAG 419
S++ I N +ED G Y+ +N AG
Sbjct: 17272 SKLEIRNAAHEDGGIYSLTVENPAG 17296
Score = 37.7 bits (86), Expect = 0.045
Identities = 46/178 (25%), Positives = 66/178 (37%), Gaps = 11/178 (6%)
Query: 264 SAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
+A L C + G +P + W R II + L G L I VT Y
Sbjct: 30944 NATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVR 31003
Query: 322 ADGYE-QVYQTHIFQVNVPPVIRVYPESQAREP-----GVTASLRCHAEGIPKPQLGWLK 375
A V T +V VP I + + G S++ G P P + W K
Sbjct: 31004 ATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQK 31063
Query: 376 NGIDITPKLS--KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
G D+ + + ++ S V + V +D G Y AKN G+D+ L V D
Sbjct: 31064 -GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 31120
Score = 37.4 bits (85), Expect = 0.058
Identities = 51/239 (21%), Positives = 91/239 (38%), Gaps = 50/239 (20%)
Query: 340 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE-VH 398
PV + P S G TA G P P+ W +G I + ++ ++ +G++ +
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 399 ISNVRYEDTGAYTCIAKNEAG------------VDEDISSLFVED------------SAR 434
I D+G +T +A+N AG V+ + +FVE +
Sbjct: 1517 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMK 1576
Query: 435 KTRLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWA 494
G N V+ ++ +I P H P ++ G + E K + Q W
Sbjct: 1577 VRATGNPNPDIVWLKNS-DIIVP-------HKYPKIRIEGTKGEAALKIDSTVSQDSAWY 1628
Query: 495 SA--------------VNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVPVKLHY 539
+A VNV+ +F A+P +R LI+ + + + + + P+ L Y
Sbjct: 1629 TATAINKAGRDTTRCKVNVEVEF---AEPEPERKLIIPRGTYRAKEIAAPELEPLHLRY 1684
Score = 37.4 bits (85), Expect = 0.058
Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 1/126 (0%)
Query: 305 LYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE 364
++I++ + G YT A G + T PP + + + G A
Sbjct: 3205 MFISETRQSDAGEYTFVA-GRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVIS 3263
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 424
G P+P++ W K ++ + + + ED YTC AKN+ GV
Sbjct: 3264 GRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTS 3323
Query: 425 SSLFVE 430
+SL VE
Sbjct: 3324 ASLSVE 3329
Score = 37.4 bits (85), Expect = 0.058
Identities = 31/135 (22%), Positives = 54/135 (40%), Gaps = 11/135 (8%)
Query: 281 WKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVN--- 337
W + L D +I+ GD +L + GNY V HI
Sbjct: 8690 WYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRL-------VCGPHIASAKLTV 8742
Query: 338 VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEV 397
+ P + + + G T ++ C +P + W +NG + P+ + ++ ++
Sbjct: 8743 IEPAWERHLQDVTLKEGQTCTMTCQFS-VPNVKSEWFRNGRILKPQGRHKTEVEHKVHKL 8801
Query: 398 HISNVRYEDTGAYTC 412
I++VR ED G YTC
Sbjct: 8802 TIADVRAEDQGQYTC 8816
Score = 37.0 bits (84), Expect = 0.076
Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 338 VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEV 397
+PP I + PE + G + H G P P W K ++ + + S +
Sbjct: 18898 LPPKI-LMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSIL 18956
Query: 398 HISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 432
I +V +D+G Y+ A+N +G D + V D+
Sbjct: 18957 IIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 18991
Score = 36.2 bits (82), Expect = 0.13
Identities = 18/66 (27%), Positives = 29/66 (43%)
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
G + G P P + W K+GI+I + ++ N + + + + DTG Y
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLT 25863
Query: 414 AKNEAG 419
KN AG
Sbjct: 25864 LKNVAG 25869
Score = 36.2 bits (82), Expect = 0.13
Identities = 19/63 (30%), Positives = 28/63 (44%)
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
G L +G PKP + WLK+G+ + + + N + I N + E G YT I
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 27637
Query: 414 AKN 416
N
Sbjct: 27638 LDN 27640
Score = 35.8 bits (81), Expect = 0.17
Identities = 33/172 (19%), Positives = 76/172 (44%), Gaps = 15/172 (8%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G++A C + + ++W +N+ L+ I+ G L + +VT +
Sbjct: 11588 GETATFVCELSHE-KMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 11646
Query: 322 ADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCH-AEGIPKPQLGWLKNGIDI 380
Q + + + ++++ ++ + +T L+C ++ +P + W K+G +I
Sbjct: 11647 VKELSSTAQLKVLEADPYFTVKLHDKTAVEKDEIT--LKCEVSKDVP---VKWFKDGEEI 11701
Query: 381 TPKLSKQLTLQANGSE--VHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 430
P S + +++A+G + I +D G Y C + G D+ +++ VE
Sbjct: 11702 VP--SPKYSIKADGLRRILKIKKADLKDKGEYVC----DCGTDKTKANVTVE 11747
Score = 35.4 bits (80), Expect = 0.22
Identities = 20/55 (36%), Positives = 24/55 (43%)
Query: 365 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
G P P+ W K G DI P Q+T S + I +D G YT A N G
Sbjct: 20405 GKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459
Score = 35.4 bits (80), Expect = 0.22
Identities = 25/117 (21%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 303 GSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCH 362
G Y +V +V + Y++ ++ ++ + ++ G + L
Sbjct: 29410 GQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVS 29469
Query: 363 AEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
G P P + W K GID+ + T + S + + V D G YT A+N++G
Sbjct: 29470 VSGRPPPVITWSKQGIDLASRAIIDTT--ESYSLLIVDKVNRYDAGKYTIEAENQSG 29524
Score = 35.0 bits (79), Expect = 0.29
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 2/86 (2%)
Query: 338 VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANG--S 395
+PP I P + + G ++ C G P P++ W G I + + ++ +
Sbjct: 33327 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 33386
Query: 396 EVHISNVRYEDTGAYTCIAKNEAGVD 421
+ I +V+ +D G YT NE G D
Sbjct: 33387 TLIIMDVQKQDGGLYTLSLGNEFGSD 33412
Score = 34.3 bits (77), Expect = 0.49
Identities = 19/68 (27%), Positives = 31/68 (45%), Gaps = 2/68 (2%)
Query: 354 GVTASLRCHAEGIPKPQLGWLKN--GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYT 411
G T L G P P++ W K+ D+T ++ +A+ S+ ++ + D G Y
Sbjct: 18216 GDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 18275
Query: 412 CIAKNEAG 419
A N AG
Sbjct: 18276 VTATNTAG 18283
Score = 34.3 bits (77), Expect = 0.49
Identities = 45/182 (24%), Positives = 69/182 (37%), Gaps = 9/182 (4%)
Query: 261 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 320
+G++A LSC I G P I W R L ++ G +L + G YTC
Sbjct: 30546 LGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC 30605
Query: 321 YADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE--GIPKPQLGWLKN 376
A E + + P YP + V ++LR H G P P + W +
Sbjct: 30606 IATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWF-H 30664
Query: 377 GIDITPKLSKQLTLQANGSEVHI--SNV-RYEDTGAYTCIAKNEAGVDEDISSLFVEDSA 433
G + S+ +T++ H+ NV R G Y N G + I + ++D
Sbjct: 30665 GQKLLQN-SENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKP 30723
Query: 434 RK 435
K
Sbjct: 30724 DK 30725
Score = 33.5 bits (75), Expect = 0.84
Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 5/90 (5%)
Query: 336 VNVPPVIRVYPESQAREPGVTASLRCHAEG--IPKPQLGWLKNGIDITPKLSKQLTLQAN 393
V+ PP I + +++A + A L C E + ++ W K+G + Q A+
Sbjct: 32714 VSAPPKITQFLKAEASKE--IAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSAD 32771
Query: 394 GS-EVHISNVRYEDTGAYTCIAKNEAGVDE 422
G+ E+ I+N+ D G Y C E G +
Sbjct: 32772 GTYELKINNLTESDQGEYVCEISGEGGTSK 32801
Score = 33.1 bits (74), Expect = 1.1
Identities = 35/167 (20%), Positives = 63/167 (37%), Gaps = 6/167 (3%)
Query: 252 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 311
+ L T AV SC + + + W RN + F DGS++ +
Sbjct: 12827 EHLEDQTVTEFDDAVFSCQLSRE-KANVKWYRNG---REIKEGKKYKFEKDGSIHRLIIK 12882
Query: 312 TTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 370
+ + YA G E + + +F +P I P+ PG K +
Sbjct: 12883 DCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNK-DKVE 12941
Query: 371 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNE 417
+ WL+N + + Q+ + + I +++ D G Y IAK++
Sbjct: 12942 VQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDK 12988
Score = 32.7 bits (73), Expect = 1.4
Identities = 15/59 (25%), Positives = 27/59 (45%)
Query: 373 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
W+K+G +I + ++HI +V+ D G YTC+ + + L VE+
Sbjct: 11151 WMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEE 11209
Score = 32.7 bits (73), Expect = 1.4
Identities = 17/69 (24%), Positives = 29/69 (42%)
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
GVT L +G P P++ W K +++ ++ + + + NV D G Y
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILT 19767
Query: 414 AKNEAGVDE 422
+N G E
Sbjct: 19768 LENSCGKKE 19776
Score = 32.3 bits (72), Expect = 1.9
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 17/81 (20%)
Query: 348 SQAREPGVTASLRCHAEGIPKPQLGW---------LKNGIDITPKLSKQLTLQANGSEVH 398
SQ R P V +G P P+ W +K+G+ P+ QL N S +
Sbjct: 15826 SQIRIPAVI-------KGRPTPKSSWEFDGKAKKAMKDGVHDIPE-DAQLETAENSSVII 15877
Query: 399 ISNVRYEDTGAYTCIAKNEAG 419
I + TG Y+ AKN+AG
Sbjct: 15878 IPECKRSHTGKYSITAKNKAG 15898
Score = 32.3 bits (72), Expect = 1.9
Identities = 22/95 (23%), Positives = 41/95 (43%), Gaps = 3/95 (3%)
Query: 340 PVIRV---YPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE 396
P I+V + ++ + G L G P P + W K+G ++ ++ + +
Sbjct: 21459 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN 21518
Query: 397 VHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 431
+ + D+GAYT A N G + I ++ V D
Sbjct: 21519 LVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLD 21553
Score = 32.0 bits (71), Expect = 2.4
Identities = 24/87 (27%), Positives = 35/87 (40%), Gaps = 7/87 (8%)
Query: 338 VPPVIRV---YPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQAN- 393
VPP + + E + G T G+P P W +G +I K + T++ +
Sbjct: 17506 VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI--KTDEHYTVETDN 17563
Query: 394 -GSEVHISNVRYEDTGAYTCIAKNEAG 419
S + I N DTG Y N AG
Sbjct: 17564 FSSVLTIKNCLRRDTGEYQITVSNAAG 17590
Score = 31.6 bits (70), Expect = 3.2
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 9/75 (12%)
Query: 359 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE--VHISNVRYEDTGAYTCIAKN 416
L+C P + W K+G +I P SK ++A+G + + + D G YTC
Sbjct: 12037 LQCEISKADAP-VKWFKDGKEIKP--SKNAVIKADGKKRMLILKKALKSDIGQYTC---- 12089
Query: 417 EAGVDEDISSLFVED 431
+ G D+ L +ED
Sbjct: 12090 DCGTDKTSGKLDIED 12104
Score = 31.6 bits (70), Expect = 3.2
Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 10/92 (10%)
Query: 338 VPPVIR----VYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDIT-PKLSKQLTLQA 392
VPP I+ V ++ + G + G+P P++ W KN I P + Q+T +
Sbjct: 15393 VPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEE 15452
Query: 393 NG-----SEVHISNVRYEDTGAYTCIAKNEAG 419
+E+ I ED G YT A N G
Sbjct: 15453 VSRSEAKTELSIPKAVREDKGTYTVTASNRLG 15484
Score = 31.2 bits (69), Expect = 4.2
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 5/87 (5%)
Query: 347 ESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTL---QANGSEVHISNVR 403
+SQ G A R G P P+ W KNG+ I + S ++ + N E+ I +V
Sbjct: 2085 QSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI--ERSDRIYWYWPEDNVCELVIRDVT 2142
Query: 404 YEDTGAYTCIAKNEAGVDEDISSLFVE 430
ED+ + A N AG + L V+
Sbjct: 2143 AEDSASIMVKAINIAGETSSHAFLLVQ 2169
Score = 31.2 bits (69), Expect = 4.2
Identities = 18/66 (27%), Positives = 26/66 (39%)
Query: 354 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 413
G T + +G P+P + W K G + + L E+ I D G Y
Sbjct: 17923 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIIS 17982
Query: 414 AKNEAG 419
AKN +G
Sbjct: 17983 AKNSSG 17988
Score = 30.8 bits (68), Expect = 5.4
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 362 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
+ G P P + W N + + + + T A S + I N + G Y+ +AKNEAG
Sbjct: 16547 YVSGKPPPTVTWNMNERTLPQEATIETT--AISSSMVIKNCQRSHQGVYSLLAKNEAG 16602
Score = 30.4 bits (67), Expect = 7.1
Identities = 18/71 (25%), Positives = 29/71 (40%)
Query: 359 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 418
L+ +G P P + W K + + A + + + + + D G YT KN A
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 20061
Query: 419 GVDEDISSLFV 429
G E S+ V
Sbjct: 20062 GTKEGTISIKV 20072
Score = 30.0 bits (66), Expect = 9.3
Identities = 16/61 (26%), Positives = 27/61 (44%)
Query: 262 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 321
G+S + +QG P + W ++ + + +I D SL++ T H G YT
Sbjct: 27973 GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVE 28032
Query: 322 A 322
A
Sbjct: 28033 A 28033
Score = 30.0 bits (66), Expect = 9.3
Identities = 20/103 (19%), Positives = 39/103 (37%)
Query: 327 QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSK 386
+V F ++ P I + S G + + P ++ W NG+++
Sbjct: 32361 EVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKI 32420
Query: 387 QLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 429
T + + I + +D+G Y + N G D ++L V
Sbjct: 32421 HYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDV 32463
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,400,033
Number of Sequences: 37866
Number of extensions: 1510611
Number of successful extensions: 6636
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 211
Number of HSP's that attempted gapping in prelim test: 3600
Number of HSP's gapped (non-prelim): 1940
length of query: 837
length of database: 18,247,518
effective HSP length: 111
effective length of query: 726
effective length of database: 14,044,392
effective search space: 10196228592
effective search space used: 10196228592
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.