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Search of human proteins with 190358520
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190358520 follistatin-like 5 isoform a [Homo sapiens]
(847 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190358520 follistatin-like 5 isoform a [Homo sapiens] 1736 0.0
gi|190358522 follistatin-like 5 isoform b [Homo sapiens] 1730 0.0
gi|190358524 follistatin-like 5 isoform c [Homo sapiens] 1701 0.0
gi|54792136 follistatin-like 4 [Homo sapiens] 994 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 96 2e-19
gi|5901956 follistatin-like 1 precursor [Homo sapiens] 89 1e-17
gi|134244585 putative neuronal cell adhesion molecule [Homo sapi... 86 1e-16
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 83 9e-16
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 83 9e-16
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 83 9e-16
gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor [... 79 2e-14
gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor [... 77 9e-14
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 76 1e-13
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 75 2e-13
gi|119220552 sidekick 1 [Homo sapiens] 75 3e-13
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 75 3e-13
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 75 3e-13
gi|83281200 protogenin [Homo sapiens] 74 4e-13
gi|109150416 peroxidasin [Homo sapiens] 74 6e-13
gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor [... 73 1e-12
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 72 3e-12
gi|224994173 roundabout 1 isoform d [Homo sapiens] 71 4e-12
gi|224994171 roundabout 1 isoform c [Homo sapiens] 71 4e-12
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 71 4e-12
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 71 4e-12
gi|19882241 immunoglobulin superfamily, DCC subclass, member 4 [... 71 4e-12
gi|19743806 roundabout 1 isoform b [Homo sapiens] 70 6e-12
gi|4506569 roundabout 1 isoform a [Homo sapiens] 70 6e-12
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 70 6e-12
gi|110349719 titin isoform N2-A [Homo sapiens] 70 8e-12
>gi|190358520 follistatin-like 5 isoform a [Homo sapiens]
Length = 847
Score = 1736 bits (4497), Expect = 0.0
Identities = 847/847 (100%), Positives = 847/847 (100%)
Query: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKQEKNQESSRVKGFMIQDG 60
MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKQEKNQESSRVKGFMIQDG
Sbjct: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKQEKNQESSRVKGFMIQDG 60
Query: 61 PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL 120
PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL
Sbjct: 61 PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL 120
Query: 121 KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV 180
KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV
Sbjct: 121 KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV 180
Query: 181 DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR 240
DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR
Sbjct: 181 DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR 240
Query: 241 AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 300
AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF
Sbjct: 241 AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 300
Query: 301 GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 360
GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL
Sbjct: 301 GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 360
Query: 361 RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG
Sbjct: 361 RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
Query: 421 VDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE 480
VDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE
Sbjct: 421 VDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE 480
Query: 481 KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST 540
KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST
Sbjct: 481 KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST 540
Query: 541 DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD 600
DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD
Sbjct: 541 DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD 600
Query: 601 FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY 660
FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY
Sbjct: 601 FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY 660
Query: 661 YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY 720
YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY
Sbjct: 661 YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY 720
Query: 721 ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK 780
ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK
Sbjct: 721 ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK 780
Query: 781 SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT 840
SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT
Sbjct: 781 SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT 840
Query: 841 VIWVGDA 847
VIWVGDA
Sbjct: 841 VIWVGDA 847
>gi|190358522 follistatin-like 5 isoform b [Homo sapiens]
Length = 846
Score = 1730 bits (4480), Expect = 0.0
Identities = 846/847 (99%), Positives = 846/847 (99%), Gaps = 1/847 (0%)
Query: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKQEKNQESSRVKGFMIQDG 60
MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHK EKNQESSRVKGFMIQDG
Sbjct: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHK-EKNQESSRVKGFMIQDG 59
Query: 61 PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL 120
PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL
Sbjct: 60 PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL 119
Query: 121 KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV 180
KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV
Sbjct: 120 KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV 179
Query: 181 DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR 240
DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR
Sbjct: 180 DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR 239
Query: 241 AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 300
AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF
Sbjct: 240 AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 299
Query: 301 GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 360
GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL
Sbjct: 300 GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 359
Query: 361 RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG
Sbjct: 360 RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
Query: 421 VDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE 480
VDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE
Sbjct: 420 VDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE 479
Query: 481 KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST 540
KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST
Sbjct: 480 KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST 539
Query: 541 DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD 600
DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD
Sbjct: 540 DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD 599
Query: 601 FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY 660
FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY
Sbjct: 600 FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY 659
Query: 661 YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY 720
YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY
Sbjct: 660 YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY 719
Query: 721 ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK 780
ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK
Sbjct: 720 ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK 779
Query: 781 SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT 840
SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT
Sbjct: 780 SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT 839
Query: 841 VIWVGDA 847
VIWVGDA
Sbjct: 840 VIWVGDA 846
>gi|190358524 follistatin-like 5 isoform c [Homo sapiens]
Length = 837
Score = 1701 bits (4404), Expect = 0.0
Identities = 836/847 (98%), Positives = 836/847 (98%), Gaps = 10/847 (1%)
Query: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHKQEKNQESSRVKGFMIQDG 60
MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHK EKNQESSRVKGFMIQDG
Sbjct: 1 MFKCWSVVLVLGFIFLESEGRPTKEGGYGLKSYQPLMRLRHK-EKNQESSRVKGFMIQDG 59
Query: 61 PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL 120
PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL
Sbjct: 60 PFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACL 119
Query: 121 KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV 180
KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV
Sbjct: 120 KKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRKKLLV 179
Query: 181 DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR 240
DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR
Sbjct: 180 DQMFKYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADKHLALEEFYR 239
Query: 241 AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 300
AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF
Sbjct: 240 AFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 299
Query: 301 GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 360
GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL
Sbjct: 300 GDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 359
Query: 361 RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG
Sbjct: 360 RCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 419
Query: 421 VDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE 480
VDEDISSLFVEDSARKT LGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE
Sbjct: 420 VDEDISSLFVEDSARKTR---------LGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSE 470
Query: 481 KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST 540
KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST
Sbjct: 471 KLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVST 530
Query: 541 DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD 600
DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD
Sbjct: 531 DPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGNVPHHTIHTQPVGKQFDRVDD 590
Query: 601 FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY 660
FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY
Sbjct: 591 FFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTINLKDYKCVPQSLAYTHLGGY 650
Query: 661 YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY 720
YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY
Sbjct: 651 YFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVSPDGHYLVSINDVKGLVRVQY 710
Query: 721 ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK 780
ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK
Sbjct: 711 ITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSSSTQTDVLFVELSSGKVKMIK 770
Query: 781 SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT 840
SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT
Sbjct: 771 SLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFILDGRLNKLNCEITEVEKGNT 830
Query: 841 VIWVGDA 847
VIWVGDA
Sbjct: 831 VIWVGDA 837
>gi|54792136 follistatin-like 4 [Homo sapiens]
Length = 842
Score = 994 bits (2571), Expect = 0.0
Identities = 470/806 (58%), Positives = 617/806 (76%), Gaps = 7/806 (0%)
Query: 42 KQEKNQESSRVKGFMIQDGPFGSCENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVC 101
++ ++ E +R +G + SC K+C G CV SR+TG+ EC C++ C+ Y PVC
Sbjct: 42 EEPRSFEVTRREGLSSHNELLASCGKKFCSRGSRCVLSRKTGEPECQCLEACRPSYVPVC 101
Query: 102 GSDGEFYENHCEVHRAACLKKQKITIVHNEDCFFKGDKCKTTEYSKMKNMLLDLQNQKYI 161
GSDG FYENHC++HRAACL ++IT++H++DCF KGD C Y+++KN+LL LQ +
Sbjct: 102 GSDGRFYENHCKLHRAACLLGKRITVIHSKDCFLKGDTCTMAGYARLKNVLLALQTRLQP 161
Query: 162 MQENENPNGDDISRKKLLVDQMFKYFDADSNGLVDINELTQ-VIKQEELGKDLFDCTLYV 220
+QE ++ D S+K+LLV+ +F+ DAD NG + +EL Q V+K+++L +DL C+
Sbjct: 162 LQEGDSRQ-DPASQKRLLVESLFRDLDADGNGHLSSSELAQHVLKKQDLDEDLLGCSPGD 220
Query: 221 LLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPI 280
LL++DD+N+D L L EFY AFQV+QLSL + ++S+T TVG S VL+CA+ G LRPPI
Sbjct: 221 LLRFDDYNSDSSLTLREFYMAFQVVQLSLAPEDRVSVTTVTVGLSTVLTCAVHGDLRPPI 280
Query: 281 IWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVP 340
IWKRN + LN LDLEDINDFG+D SLYITKVTT H+GNYTC+A G+EQ++QTH+ QVNVP
Sbjct: 281 IWKRNGLTLNFLDLEDINDFGEDDSLYITKVTTIHMGNYTCHASGHEQLFQTHVLQVNVP 340
Query: 341 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHI 400
PVIRVYPESQA+EPGV ASLRCHAEGIP P++ WLKNG+D++ ++SKQL+L ANGSE+HI
Sbjct: 341 PVIRVYPESQAQEPGVAASLRCHAEGIPMPRITWLKNGVDVSTQMSKQLSLLANGSELHI 400
Query: 401 SNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEGLGIGNMFYVFYED 460
S+VRYEDTGAYTCIAKNE GVDEDISSLF+EDSARKTLANILWREEGL +GNMFYVF +D
Sbjct: 401 SSVRYEDTGAYTCIAKNEVGVDEDISSLFIEDSARKTLANILWREEGLSVGNMFYVFSDD 460
Query: 461 GIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWASAVNVKDKFIYVAQPT 520
GI VI P++CE QRH+KP+EK+ +E+CP+ E + Q C W SAVNV++++IYVAQP
Sbjct: 461 GIIVIHPVDCEIQRHLKPTEKIFMSYEEICPQREKNATQPCQWVSAVNVRNRYIYVAQPA 520
Query: 521 LDRVLIVDVQSQKVVQAVSTDPVPVKLHYDKSHDQVWVLSWGTLEKTSPTLQVITLASGN 580
L RVL+VD+Q+QKV+Q++ DP+P KL YDKSHDQVWVLSWG + K+ P+LQVIT AS
Sbjct: 521 LSRVLVVDIQAQKVLQSIGVDPLPAKLSYDKSHDQVWVLSWGDVHKSRPSLQVITEASTG 580
Query: 581 VPHHTIHTQPVGKQFDRVDDFFIPTTTLIITHMRFGFILHKDEAALQKIDLETMSYIKTI 640
H I T F VDDFFIP T LII H+RFGFI +K + A+ K+DLETM +KTI
Sbjct: 581 QSQHLIRT-----PFAGVDDFFIPPTNLIINHIRFGFIFNKSDPAVHKVDLETMMPLKTI 635
Query: 641 NLKDYKCVPQSLAYTHLGGYYFIGCKPDSTGAVSPQVMVDGVTDSVIGFNSDVTGTPYVS 700
L + CVPQ++A+THLGGY+FI C+ DS + + Q++VD VTDSV+G N DVTGTP+ S
Sbjct: 636 GLHHHGCVPQAMAHTHLGGYFFIQCRQDSPASAARQLLVDSVTDSVLGPNGDVTGTPHTS 695
Query: 701 PDGHYLVSINDVKGLVRVQYITIRGEIQEAFDIYTNLHISDLAFQPSFTEAHQYNIYGSS 760
PDG ++VS + VQ IT+RGEIQ +D+ N ISDLAFQ SFTE++QYNIY +
Sbjct: 696 PDGRFIVSAAADSPWLHVQEITVRGEIQTLYDLQINSGISDLAFQRSFTESNQYNIYAAL 755
Query: 761 STQTDVLFVELSSGKVKMIKSLKEPLKAEEWPWNRKNRQIQDSGLFGQYLMTPSKDSLFI 820
T+ D+LF+ELS+GKV M+K+LKEP PW +R ++DSGLFGQYL+TP+++SLF+
Sbjct: 756 HTEPDLLFLELSTGKVGMLKNLKEPPAGPAQPWGGTHRIMRDSGLFGQYLLTPARESLFL 815
Query: 821 LDGRLNKLNCEITEVEKGNTVIWVGD 846
++GR N L CE++ ++ G TV+WVG+
Sbjct: 816 INGRQNTLRCEVSGIKGGTTVVWVGE 841
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 95.5 bits (236), Expect = 2e-19
Identities = 57/183 (31%), Positives = 86/183 (46%), Gaps = 3/183 (1%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
E + + T+ L+C G P I W +N+ + N D ++ L I +
Sbjct: 3154 EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIAR 3213
Query: 311 VTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIR--VYPESQAREPGVTASLRCHAEGI 367
+ GNYTC A E Q + F + VPP + P + G L C+A GI
Sbjct: 3214 SQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNANGI 3273
Query: 368 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISS 427
P P + WLK+G I ++++ + ANGS ++I DTG YTC+A N AG ++ I +
Sbjct: 3274 PTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFN 3333
Query: 428 LFV 430
L V
Sbjct: 3334 LNV 3336
Score = 75.9 bits (185), Expect = 1e-13
Identities = 60/223 (26%), Positives = 99/223 (44%), Gaps = 21/223 (9%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
VGQ + C QGT P I W + + +++ DG+L I + T + G YTC
Sbjct: 1184 VGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSN--PDGTLSIDQATPSDAGIYTC 1241
Query: 322 YADGYEQVYQTHI-FQVNVPPVIRVYPES-----QAREPGVTASLRCHAEGIPKPQLGWL 375
A +T I V PP + Q R C A+G PKP + WL
Sbjct: 1242 VATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWL 1301
Query: 376 KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSL------F 429
NG ++T + +++ +G+ + I++V D G Y C+A NEAG E +L
Sbjct: 1302 HNGRELTGR-EPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPPV 1360
Query: 430 VEDSARKTLANILWRE------EGLGIGNMFYVFYEDGIKVIQ 466
++D + T ++L + E G + ++Y+D ++V +
Sbjct: 1361 IKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTE 1403
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/178 (32%), Positives = 81/178 (45%), Gaps = 9/178 (5%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G+ LSC G P + W NN I+ + +N + L I +V+ G Y C
Sbjct: 4274 GEQLRLSCKATGIPLPKLTWTFNNNIIP-AHFDSVNGHSE---LVIERVSKEDSGTYVCT 4329
Query: 323 ADGYEQVYQTHIF-QVNVPPVIRV-YPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 380
A+ + F V PPV + YP + G A L C +G P P + W + G+D
Sbjct: 4330 AENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVD 4389
Query: 381 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTL 438
I ++S ++ NGS V ED G YTC+A NEAGV E SL ++ TL
Sbjct: 4390 I--EISHRIRQLGNGSLAIYGTVN-EDAGDYTCVATNEAGVVERSMSLTLQSPPIITL 4444
Score = 74.7 bits (182), Expect = 3e-13
Identities = 54/172 (31%), Positives = 76/172 (44%), Gaps = 5/172 (2%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
+ +S VL C +G P I W+++ +L ++G L+I T G Y C
Sbjct: 3726 LNKSTVLECIAEGVPTPRITWRKDGAVLAGNHAR--YSILENGFLHIQSAHVTDTGRYLC 3783
Query: 322 YADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG-I 379
A + I QV+VPP I P + V +L C A GIPKP + W KNG +
Sbjct: 3784 MATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHL 3843
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ L ++GS V IS +DT Y C N AG D+ L V+
Sbjct: 3844 LNVDQNQNSYRLLSSGSLVIIS-PSVDDTATYECTVTNGAGDDKRTVDLTVQ 3894
Score = 73.2 bits (178), Expect = 1e-12
Identities = 52/188 (27%), Positives = 83/188 (44%), Gaps = 6/188 (3%)
Query: 246 QLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS 305
Q L +D+ + I+ G+ L C ++ P I W + +++ + F GS
Sbjct: 1078 QRGLSQDKPVEISVLA-GEEVTLPCEVKSLPPPIITWAKETQLISPFSPR--HTFLPSGS 1134
Query: 306 LYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHA 364
+ IT+ T+ G Y C A V Q V+VPP I+ P+ + G + C+A
Sbjct: 1135 MKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNA 1194
Query: 365 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDED 424
+G P P + W K G T + + + + I D G YTC+A N AG DE
Sbjct: 1195 QGTPLPVITWSKGG--STMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDET 1252
Query: 425 ISSLFVED 432
+L V++
Sbjct: 1253 EITLHVQE 1260
Score = 72.8 bits (177), Expect = 1e-12
Identities = 49/169 (28%), Positives = 76/169 (44%), Gaps = 5/169 (2%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
T G+ AVL+C I + + W+RN+ + + I + SL + V G Y
Sbjct: 532 TPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANL-SLELKSVKFNDAGEYH 590
Query: 321 CYADGYEQVYQTHIF-QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
C +F V PP + V P++Q+ G S+ C A G PKP++ W N +
Sbjct: 591 CMVSSEGGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDM 650
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSL 428
I ++T + + I N +D G Y C+A N AG D+ S+L
Sbjct: 651 FIVGSHRYRMT---SDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTL 696
Score = 72.8 bits (177), Expect = 1e-12
Identities = 58/171 (33%), Positives = 76/171 (44%), Gaps = 8/171 (4%)
Query: 262 VGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
V + LSC G P I W K I+ ++ ++ GSL I V G+YT
Sbjct: 4092 VDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSS----GSLQIAFVQPGDAGHYT 4147
Query: 321 CYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
C A T V+VPP IR A L C A+GIP P + W K+ +
Sbjct: 4148 CMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNV 4207
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
+ L K T + G E+ + NV ED+G YTC+A N AG D SL V
Sbjct: 4208 LLANLLGKY-TAEPYG-ELILENVVLEDSGFYTCVANNAAGEDTHTVSLTV 4256
Score = 71.6 bits (174), Expect = 3e-12
Identities = 50/174 (28%), Positives = 78/174 (44%), Gaps = 8/174 (4%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
T G+S L C +QG P + W ++ L +I D G L + + + G Y
Sbjct: 2305 TRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGH--ILQLKNIHVSDTGRYV 2362
Query: 321 CYADGYEQVY-QTHIFQVNVPPVI---RVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 376
C A + + + V+ PP I PE+ + + SL C A GIP P + W K
Sbjct: 2363 CVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFK 2422
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
+G ++ LS + + + G + + ED G YTC+ +N AG + I L V
Sbjct: 2423 DGWPVS--LSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSV 2474
Score = 71.6 bits (174), Expect = 3e-12
Identities = 58/214 (27%), Positives = 87/214 (40%), Gaps = 13/214 (6%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
V L+C G +P I W++N +LN ++ GSL I + Y C
Sbjct: 3817 VNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYEC 3876
Query: 322 -YADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 380
+G +T V VPP I P A + C A G+P P + W KNGI
Sbjct: 3877 TVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIR 3936
Query: 381 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED-------- 432
+ P+ L + E+ + + + G YTC+A+N AG +L V +
Sbjct: 3937 LLPRGDGYRILSSGAIEILATQLNH--AGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQP 3994
Query: 433 SARKTLAN--ILWREEGLGIGNMFYVFYEDGIKV 464
S + N IL E G + F + ++GI V
Sbjct: 3995 SELHVILNNPILLPCEATGTPSPFITWQKEGINV 4028
Score = 70.9 bits (172), Expect = 5e-12
Identities = 53/171 (30%), Positives = 75/171 (43%), Gaps = 13/171 (7%)
Query: 266 AVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD--GSLYITKVTTTHVGNYTCYA 323
A+L C G P I WK++N++L NL + + + G L + V G YTC A
Sbjct: 4186 AILPCVADGIPTPAINWKKDNVLLANL----LGKYTAEPYGELILENVVLEDSGFYTCVA 4241
Query: 324 DGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDIT 382
+ + T V+V P P + G L C A GIP P+L W N I
Sbjct: 4242 NNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIP 4301
Query: 383 PKLSKQLTLQANG-SEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
NG SE+ I V ED+G Y C A+N G + I ++V++
Sbjct: 4302 AHFD-----SVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKE 4347
Score = 70.1 bits (170), Expect = 8e-12
Identities = 54/165 (32%), Positives = 74/165 (44%), Gaps = 9/165 (5%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LYITKVTTTHVGNYTC 321
G S ++C GT P + W R+ L L+ G L + K T G YTC
Sbjct: 3450 GSSTSMACITDGTPAPSMAWLRDG---QPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTC 3506
Query: 322 YADGYEQVYQTH-IFQVNVPPVIRVYPESQAREPGVT--ASLRCHAEGIPKPQLGWLKNG 378
A H I +V PP I E + V L C A GIP P++ W+K+G
Sbjct: 3507 IASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDG 3566
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ P+ + TL G + IS + EDTG YTC+A + AG D+
Sbjct: 3567 RPL-PQTDQVQTL-GGGEVLRISTAQVEDTGRYTCLASSPAGDDD 3609
Score = 69.3 bits (168), Expect = 1e-11
Identities = 57/186 (30%), Positives = 83/186 (44%), Gaps = 15/186 (8%)
Query: 249 LPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LY 307
LPE+ V +SA++ C G+ P W+++ L +D + F +G L
Sbjct: 2878 LPEE-----VTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLE---DDHHKFLSNGRILQ 2929
Query: 308 ITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVT--ASLRCHA 364
I T +G Y C A+ + + V+VPP + + P+S+ V SL C
Sbjct: 2930 ILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSV-IGPKSENLTVVVNNFISLTCEV 2988
Query: 365 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDED 424
G P P L WLKN I KL+ + G + I + D G YTCIA N+AG +
Sbjct: 2989 SGFPPPDLSWLKNEQPI--KLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKK 3046
Query: 425 ISSLFV 430
SL V
Sbjct: 3047 KFSLTV 3052
Score = 68.9 bits (167), Expect = 2e-11
Identities = 51/160 (31%), Positives = 68/160 (42%), Gaps = 5/160 (3%)
Query: 264 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA 323
+ L C P I W RN L I G L I NYTC A
Sbjct: 3637 RQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGR--YLQINNADLGDTANYTCVA 3694
Query: 324 DGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDIT 382
+ + I VNVPP I+ P+S + L C AEG+P P++ W K+G +
Sbjct: 3695 SNIAGKTTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLA 3754
Query: 383 PKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
++ L+ NG +HI + DTG Y C+A N AG D
Sbjct: 3755 GNHARYSILE-NGF-LHIQSAHVTDTGRYLCMATNAAGTD 3792
Score = 68.9 bits (167), Expect = 2e-11
Identities = 47/163 (28%), Positives = 78/163 (47%), Gaps = 13/163 (7%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLE---DINDFGDDGSLYITKVTTTHVGN 318
+G +A+L+C ++G P I W R + D+E I G+ GSL I G+
Sbjct: 4363 LGGNAILNCEVKGDPTPTIQWNRKGV-----DIEISHRIRQLGN-GSLAIYGTVNEDAGD 4416
Query: 319 YTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKN 377
YTC A V + + + PP+I + P G L C A G P+P + W +
Sbjct: 4417 YTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQ 4476
Query: 378 GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
G I+ ++ + +N S ++I++ + EDT + C+A+N G
Sbjct: 4477 GHSIS--WDDRVNVLSNNS-LYIADAQKEDTSEFECVARNLMG 4516
Score = 66.2 bits (160), Expect = 1e-10
Identities = 51/176 (28%), Positives = 82/176 (46%), Gaps = 11/176 (6%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNN---IILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
+G + L C +QG P I W+R + I + I+ G+L+I + + G
Sbjct: 806 IGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRT-GALFILNLWASDKGT 864
Query: 319 YTCYAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHA-EGIPKPQLGW 374
Y C A+ G Q T V P+I + P G +L C G P P+ W
Sbjct: 865 YICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRW 924
Query: 375 LKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
+KN + + +T++++GS +HI V+ +D G YTC+A N AG + +S+ V
Sbjct: 925 IKNSAMLLQ--NPYITVRSDGS-LHIERVQLQDGGEYTCVASNVAGTNNKTTSVVV 977
Score = 66.2 bits (160), Expect = 1e-10
Identities = 51/172 (29%), Positives = 74/172 (43%), Gaps = 10/172 (5%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
V S + C GT P I W +N + L I + I + + V YTC
Sbjct: 3356 VDTSINIECRATGTPPPQINWLKNGLPLPLSS--HIRLLAAGQVIRIVRAQVSDVAVYTC 3413
Query: 322 YADGYEQVYQTHI-FQVNVPPVI--RVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 378
A V H QV PP + + E G + S+ C +G P P + WL++G
Sbjct: 3414 VASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDG 3473
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
+ L LT+ +G + + ED+G YTCIA NEAG ++S F+
Sbjct: 3474 QPLG--LDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAG---EVSKHFI 3520
Score = 65.5 bits (158), Expect = 2e-10
Identities = 47/169 (27%), Positives = 73/169 (43%), Gaps = 4/169 (2%)
Query: 256 SITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH 315
++ A V L C +G P + W ++ +++ + L +T +
Sbjct: 2019 NMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFS-NGLQVLSGGRILALTSAQISD 2077
Query: 316 VGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 374
G YTC A Q I +V VPP I ++ + L C ++ IP P L W
Sbjct: 2078 TGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTW 2137
Query: 375 LKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
LK+G + K L++ N S + I + + +DTG YTC A N AG E
Sbjct: 2138 LKDGHPLLKKPG--LSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTE 2184
Score = 65.5 bits (158), Expect = 2e-10
Identities = 52/181 (28%), Positives = 76/181 (41%), Gaps = 16/181 (8%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLY 307
P+ + L++ V L+C + G P + W +N I LN L +L
Sbjct: 2969 PKSENLTVV---VNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLI----VPGGRTLQ 3021
Query: 308 ITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAR----EPGVTASLRC 362
I + + G YTC A + + V VPP I+ + G + SL C
Sbjct: 3022 IIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLEC 3081
Query: 363 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
+ +P P + W KNG IT S + + A+G +HI DTG Y C A N AG D
Sbjct: 3082 ESNAVPPPVITWYKNGRMITE--STHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRD 3139
Query: 423 E 423
+
Sbjct: 3140 D 3140
Score = 64.3 bits (155), Expect = 5e-10
Identities = 49/170 (28%), Positives = 77/170 (45%), Gaps = 11/170 (6%)
Query: 268 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYE 327
L C + G+ P I+W ++ +++ D I G L I + ++ G Y C A
Sbjct: 1754 LDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGR--KLVIAQAQVSNTGLYRCMAANTA 1811
Query: 328 QVYQTHI-FQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLGWLKNGIDIT 382
++ V+VPP I+ S E V +L+C A GIP P + WLK+ +
Sbjct: 1812 GDHKKEFEVTVHVPPTIK---SSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVN 1868
Query: 383 PKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
L +Q++G + I+ ED G YTC+A N AG + L V +
Sbjct: 1869 TAQGN-LKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHE 1917
Score = 64.3 bits (155), Expect = 5e-10
Identities = 46/164 (28%), Positives = 72/164 (43%), Gaps = 12/164 (7%)
Query: 264 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA 323
QS L+C + G P I W ++ L + I G L IT V H G YTC A
Sbjct: 2495 QSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGR--FLQITNVQVPHTGRYTCLA 2552
Query: 324 DGYEQVYQTHIFQVNV---PPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLGWLK 376
+++ F +NV P + V + + V SL C A P + W K
Sbjct: 2553 SS-PAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFK 2611
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+G + + ++ + + G + I N + ++ G Y+C+A NEAG
Sbjct: 2612 DGTPL--ESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653
Score = 63.9 bits (154), Expect = 6e-10
Identities = 51/176 (28%), Positives = 73/176 (41%), Gaps = 8/176 (4%)
Query: 248 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 307
SL + K+ V L C G P I W ++N +L+ + G +
Sbjct: 1920 SLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQ--IID 1977
Query: 308 ITKVTTTHVGNYTCYADGYEQVYQTHIF---QVNVPPVIRVYPESQAREPGVTASLRCHA 364
I + G Y C A T +F QV+V P I A L C A
Sbjct: 1978 IESAQISDAGIYKCVA--INSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEA 2035
Query: 365 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
GIP P L WLK+G ++ S L + + G + +++ + DTG YTC+A N AG
Sbjct: 2036 RGIPAPSLTWLKDGSPVS-SFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAG 2090
Score = 63.5 bits (153), Expect = 8e-10
Identities = 43/175 (24%), Positives = 74/175 (42%), Gaps = 6/175 (3%)
Query: 249 LPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYI 308
+ + ++++ + + Q L C ++GT P I+W ++N+ + + I + L +
Sbjct: 1361 IKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVT--ESSTIQTVNNGKILKL 1418
Query: 309 TKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVI--RVYPESQAREPGVTASLRCHAE 365
+ T G Y+C A Q + V VPP I +P + +L C +
Sbjct: 1419 FRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVK 1478
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
G P P + W K+G + + L G +H+ N R D G Y C N AG
Sbjct: 1479 GTPFPDIHWFKDGKPLFLG-DPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAG 1532
Score = 63.5 bits (153), Expect = 8e-10
Identities = 46/165 (27%), Positives = 70/165 (42%), Gaps = 6/165 (3%)
Query: 267 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY 326
+L C GT P I W++ I +N + G L I++ G Y C A
Sbjct: 4006 LLPCEATGTPSPFITWQKEGINVNTSGRN--HAVLPSGGLQISRAVREDAGTYMCVAQNP 4063
Query: 327 EQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKL 385
I V VPPVI + + +L C A+G+P P + W K+G I +
Sbjct: 4064 AGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESI 4123
Query: 386 SKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
+++ + + I+ V+ D G YTC+A N AG + L V
Sbjct: 4124 RQRV---LSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTV 4165
Score = 62.0 bits (149), Expect = 2e-09
Identities = 49/167 (29%), Positives = 76/167 (45%), Gaps = 7/167 (4%)
Query: 256 SITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 314
S+ GQ L C + G P W +N+ +L + DGSL+I +V
Sbjct: 897 SVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRS---DGSLHIERVQLQ 953
Query: 315 HVGNYTCYADGYEQVY-QTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLG 373
G YTC A +T V+V P I+ + + G+ +L C A G PKP +
Sbjct: 954 DGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVI 1013
Query: 374 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
W K G ++ S + + A+GS +++ + E++G Y C A N AG
Sbjct: 1014 WSKKG-ELISTSSAKFSAGADGS-LYVVSPGGEESGEYVCTATNTAG 1058
Score = 62.0 bits (149), Expect = 2e-09
Identities = 38/128 (29%), Positives = 59/128 (46%), Gaps = 11/128 (8%)
Query: 305 SLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIR--------VYPESQAREPG 355
+L I + G Y+C A ++ + + +V +PP+I + P+ +
Sbjct: 2630 TLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVN 2689
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
T +L C A IP L W K+G + K + + ANG + I + DTG YTC+A
Sbjct: 2690 NTLTLECEAYAIPSASLSWYKDGQPL--KSDDHVNIAANGHTLQIKEAQISDTGRYTCVA 2747
Query: 416 KNEAGVDE 423
N AG DE
Sbjct: 2748 SNIAGEDE 2755
Score = 59.3 bits (142), Expect = 1e-08
Identities = 47/159 (29%), Positives = 68/159 (42%), Gaps = 10/159 (6%)
Query: 270 CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGYEQ 328
C +GT +P I W N L + I+ D L I VT G Y C A +
Sbjct: 1288 CPAKGTPKPTIKWLHNGRELTGRE-PGISILEDGTLLVIASVTPYDNGEYICVAVNEAGT 1346
Query: 329 VYQTHIFQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLGWLKNGIDITPK 384
+ + +V+VPPVI+ + Q V +L C EG P P + W K+ + +T
Sbjct: 1347 TERKYNLKVHVPPVIK--DKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTE- 1403
Query: 385 LSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
S + NG + + ED G Y+C A N AG +
Sbjct: 1404 -SSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQ 1441
Score = 58.5 bits (140), Expect = 2e-08
Identities = 44/163 (26%), Positives = 74/163 (45%), Gaps = 14/163 (8%)
Query: 268 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY----A 323
L C +G P I W ++ + + D G L+I + + YTC+ A
Sbjct: 1567 LECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQ--YLHIPRAQVSDSATYTCHVANVA 1624
Query: 324 DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTA---SLRCHAEGIPKPQLGWLKNGID 380
E+ + ++ VPP+I + + V A +L C A G P P L WLK+G+
Sbjct: 1625 GTAEKSFHVDVY---VPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVP 1681
Query: 381 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ K + + ++A G ++ I + + D G Y C+A + AG E
Sbjct: 1682 V--KANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKE 1722
Score = 54.7 bits (130), Expect = 4e-07
Identities = 46/166 (27%), Positives = 65/166 (39%), Gaps = 6/166 (3%)
Query: 268 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYE 327
L C G P I W +++ +N ++ L I K G YTC A
Sbjct: 1846 LQCIANGIPNPSITWLKDDQPVNTAQ-GNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAA 1904
Query: 328 QVYQTHI-FQVNVPPVIRVYPESQAREPGVT--ASLRCHAEGIPKPQLGWLKNGIDITPK 384
Q HI V+ PP + + V+ L C A G P P + W K+ ++
Sbjct: 1905 GETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGS 1964
Query: 385 LSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
S +T G + I + + D G Y C+A N AG E SL V
Sbjct: 1965 TS--MTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQV 2008
Score = 54.7 bits (130), Expect = 4e-07
Identities = 47/175 (26%), Positives = 71/175 (40%), Gaps = 19/175 (10%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
V + L C + W ++ L + D +N + +L I + + G YTC
Sbjct: 2688 VNNTLTLECEAYAIPSASLSWYKDGQPLKSDD--HVNIAANGHTLQIKEAQISDTGRYTC 2745
Query: 322 YADGYEQVYQTHIFQVN--VPPVIRVYPE----------SQAREPGVT--ASLRCHAEGI 367
A + F VN VPP + E +A++ + SL C
Sbjct: 2746 VASNIAGEDELD-FDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAA 2804
Query: 368 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
P P L W K+G +T S ++ + G + I + ED G YTC+A NEAG D
Sbjct: 2805 PPPTLTWYKDGHPLTS--SDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGED 2857
Score = 53.9 bits (128), Expect = 6e-07
Identities = 47/176 (26%), Positives = 71/176 (40%), Gaps = 14/176 (7%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
E+Q +S+ + Q+ L C P + W ++ L L ++ + L I
Sbjct: 2109 EEQNVSVL---ISQAVELLCQSDAIPPPTLTWLKDGHPL--LKKPGLSISENRSVLKIED 2163
Query: 311 VTTTHVGNYTCYADGY----EQVYQTHIFQVNVPPVIRVYPESQARE--PGVTASLRCHA 364
G YTC A E+ Y +I+ VPP I E G SL C +
Sbjct: 2164 AQVQDTGRYTCEATNVAGKTEKNYNVNIW---VPPNIGGSDELTQLTVIEGNLISLLCES 2220
Query: 365 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
GIP P L W K G + ++ + + G ++ IS D Y+C+A N AG
Sbjct: 2221 SGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAG 2276
Score = 53.5 bits (127), Expect = 8e-07
Identities = 43/164 (26%), Positives = 67/164 (40%), Gaps = 9/164 (5%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
+G V+ C G P + W + ++ L I+ G L I + G+YTC
Sbjct: 715 LGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLL--GLLKIQETQDLDAGDYTC 772
Query: 322 YADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 380
A I V PPV P + E G +L C+ +G P+P + W + +D
Sbjct: 773 VAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRR--LD 830
Query: 381 ITPKLSKQLTL----QANGSEVHISNVRYEDTGAYTCIAKNEAG 420
P S+ ++ Q + I N+ D G Y C A+N+ G
Sbjct: 831 NMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFG 874
Score = 53.1 bits (126), Expect = 1e-06
Identities = 56/226 (24%), Positives = 93/226 (41%), Gaps = 21/226 (9%)
Query: 222 LKYDDFNADKHLALEEFYRAFQVIQLSL-PEDQKLSITAATVG---QSAVLSCAIQGTLR 277
LK ++ D +L F R V S+ P+ K+++ T G Q + C++ L
Sbjct: 403 LKVTGYDKDDYL----FQRVSSVSFSSIVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLP 458
Query: 278 PPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-----DGYEQVYQT 332
+ + RN + L ++ +L I KVT + G Y C A G Q +
Sbjct: 459 FTLSFVRNGVTLG---VDQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTF-- 513
Query: 333 HIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQ 392
F V+ PP + P + PG A L C L W +N D+ ++
Sbjct: 514 --FDVSEPPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTL 571
Query: 393 ANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTL 438
AN S + + +V++ D G Y C+ +E G L V++ + T+
Sbjct: 572 ANLS-LELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTV 616
>gi|5901956 follistatin-like 1 precursor [Homo sapiens]
Length = 308
Score = 89.4 bits (220), Expect = 1e-17
Identities = 57/196 (29%), Positives = 96/196 (48%), Gaps = 26/196 (13%)
Query: 65 CENKYCGLGRHCVTSRETGQAECACMDLCKRHYKPVCGSDGEFYENHCEVHRAACLKKQK 124
C N +CG GR C + E G+ C C++ CK H +PVCGS+G+ Y NHCE+HR ACL K
Sbjct: 31 CANVFCGAGRECAVT-EKGEPTCLCIEQCKPHKRPVCGSNGKTYLNHCELHRDACLTGSK 89
Query: 125 ITIVHNEDCFFKGD--------KCKTTEYSKMKNMLLDLQNQKYIMQENENPNGDDISRK 176
I + ++ C K C + +++ ++ + I+ + G + S
Sbjct: 90 IQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAE-IIPDGWFSKGSNYSE- 147
Query: 177 KLLVDQMFKYFDADSNGLVDINELTQVIKQ------------EELGKDLFDCTLYVLLKY 224
++D+ FK FD + + +D +E + ++Q +E K L + L++
Sbjct: 148 --ILDKYFKNFD-NGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIEL 204
Query: 225 DDFNADKHLALEEFYR 240
D NAD L+ +EF +
Sbjct: 205 SDENADWKLSFQEFLK 220
>gi|134244585 putative neuronal cell adhesion molecule [Homo
sapiens]
Length = 814
Score = 86.3 bits (212), Expect = 1e-16
Identities = 65/189 (34%), Positives = 89/189 (47%), Gaps = 21/189 (11%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
TV Q+AVL C G RP + W R + + +E I G G+L I+ VT H G Y
Sbjct: 250 TVHQTAVLECVATGNPRPIVSWSR--LDGRPIGVEGIQVLGT-GNLIISDVTVQHSGVYV 306
Query: 321 CYADG----YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 376
C A+ + Q + V P +P+S +R G TA C A+G P P + WLK
Sbjct: 307 CAANRPGTRVRRTAQGRLV-VQAPAEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLK 365
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARK 436
NG + P + L+ N S + IS + ED Y C+A+N AG + SAR
Sbjct: 366 NGQVLGP--GGHVRLKNNNSTLTISGIGPEDEAIYQCVAENSAGSS--------QASARL 415
Query: 437 TLANILWRE 445
T +LW E
Sbjct: 416 T---VLWAE 421
Score = 63.5 bits (153), Expect = 8e-10
Identities = 50/188 (26%), Positives = 85/188 (45%), Gaps = 20/188 (10%)
Query: 260 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV------TT 313
A GQ VL C ++GT I W++N + L + +GSL I +
Sbjct: 53 AVPGQPIVLDCRVEGTPPVRITWRKNGV---ELPESTHSTLLANGSLMIRHFRLEPGGSP 109
Query: 314 THVGNYTCYADGYEQVYQTHIFQVNVPPV--IRVYPESQAREPGVTASLRCHAEGIPKPQ 371
+ G+Y C A + + ++ + V+P++ E G A +C G+PKP
Sbjct: 110 SDEGDYECVAQNRFGLVVSRKARIQAATMSDFHVHPQATVGEEGGVARFQCQIHGLPKPL 169
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ W KN + I +++ TL G + I+ +R ED G + C+A N I+S+ +
Sbjct: 170 ITWEKNRVPIDTD-NERYTLLPKG-VLQITGLRAEDGGIFHCVASN-------IASIRIS 220
Query: 432 DSARKTLA 439
AR T++
Sbjct: 221 HGARLTVS 228
Score = 50.1 bits (118), Expect = 9e-06
Identities = 47/168 (27%), Positives = 73/168 (43%), Gaps = 17/168 (10%)
Query: 260 ATVGQS---AVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHV 316
ATVG+ A C I G +P I W++N + ++ D E G L IT +
Sbjct: 147 ATVGEEGGVARFQCQIHGLPKPLITWEKNRVPIDT-DNERYT-LLPKGVLQITGLRAEDG 204
Query: 317 GNYTCYADGYEQVYQTHIFQVNV---------PPVIRVYPESQAREPGVTASLRCHAEGI 367
G + C A + +H ++ V P I V PE+ TA L C A G
Sbjct: 205 GIFHCVASNIASIRISHGARLTVSGSGSGAYKEPAILVGPENLTLTVHQTAVLECVATGN 264
Query: 368 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
P+P + W + +D P + + + G+ + IS+V + +G Y C A
Sbjct: 265 PRPIVSWSR--LDGRPIGVEGIQVLGTGNLI-ISDVTVQHSGVYVCAA 309
Score = 47.0 bits (110), Expect = 7e-05
Identities = 30/83 (36%), Positives = 40/83 (48%), Gaps = 9/83 (10%)
Query: 345 VYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVR 404
V P PG L C EG P ++ W KNG+++ S TL ANGS + I + R
Sbjct: 46 VEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPE--STHSTLLANGS-LMIRHFR 102
Query: 405 YE------DTGAYTCIAKNEAGV 421
E D G Y C+A+N G+
Sbjct: 103 LEPGGSPSDEGDYECVAQNRFGL 125
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 83.2 bits (204), Expect = 9e-16
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 9/185 (4%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
E+ K + G VL+C + G P + W ++ + + + + + G G L +++
Sbjct: 1936 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG--GRLQLSR 1993
Query: 311 VTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE----PGVTASLRCHAE 365
+ G YTC A+ + + + + V V P IR ARE G L C A+
Sbjct: 1994 LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIR--SSGVAREHHVLEGQEVRLDCEAD 2051
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
G P P + WLK+G + + L +G + + +R D GAYTC+A N AG D +
Sbjct: 2052 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL 2111
Query: 426 SSLFV 430
++ V
Sbjct: 2112 HTVNV 2116
Score = 76.3 bits (186), Expect = 1e-13
Identities = 55/188 (29%), Positives = 82/188 (43%), Gaps = 11/188 (5%)
Query: 237 EFYRAFQV---IQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 293
E +R +QV + ++ +DQ + T+ VL+C G P + W + L
Sbjct: 2653 EAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 2710
Query: 294 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAR 352
G+L I + H G YTC A V H+F V PV++ P
Sbjct: 2711 SG--YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA 2768
Query: 353 EPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYT 412
L C A GIP+P + W K G+++ +S Q+ G ++ I++ ED G Y
Sbjct: 2769 VAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV---LPGGQLRIAHASPEDAGNYL 2825
Query: 413 CIAKNEAG 420
CIAKN AG
Sbjct: 2826 CIAKNSAG 2833
Score = 73.6 bits (179), Expect = 7e-13
Identities = 49/173 (28%), Positives = 78/173 (45%), Gaps = 6/173 (3%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
GQ L C G P + W ++ L + + D GSL + + + G YTC
Sbjct: 2041 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2100
Query: 323 ADGYE-QVYQTHIFQVNVPPVIRVYPESQAR---EPGVTASLRCHAEGIPKPQLGWLKNG 378
A + + H V VPP I+ + PG ++ C G P + WLK+G
Sbjct: 2101 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG 2160
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ + LS++ L +G + IS V+ D G +TC+A + AGV + +L V+
Sbjct: 2161 LPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ 2211
Score = 70.9 bits (172), Expect = 5e-12
Identities = 51/191 (26%), Positives = 84/191 (43%), Gaps = 7/191 (3%)
Query: 244 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD 303
V+Q+ + L + T G A L C +G+ P I W ++ ++ E
Sbjct: 2842 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA--EGKFTIQPS 2899
Query: 304 GSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRC 362
G L + + G YTC A+ + + + V PV P ++ G LRC
Sbjct: 2900 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRC 2959
Query: 363 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
A G P P++GW N +T +S+ Q GS + + V ED+G Y C A+N G
Sbjct: 2960 AARGSPTPRIGWTVNDRPVTEGVSE----QDGGSTLQRAAVSREDSGTYVCWAENRVGRT 3015
Query: 423 EDISSLFVEDS 433
+ +S + V+++
Sbjct: 3016 QAVSFVHVKEA 3026
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/159 (30%), Positives = 77/159 (48%), Gaps = 9/159 (5%)
Query: 267 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN-DFGDDGS-LYITKVTTTHVGNYTCYA- 323
VL C+++ P I W R+ I+L ED + F + G L + ++T G+Y+C A
Sbjct: 2409 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 2464
Query: 324 DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP 383
+ +++ P IR P + TA L C A+G+P P + W K+ + + P
Sbjct: 2465 NAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP 2524
Query: 384 KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
+ S + + GS + I V +D G Y C+A N AG D
Sbjct: 2525 R-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2561
Score = 68.9 bits (167), Expect = 2e-11
Identities = 50/171 (29%), Positives = 75/171 (43%), Gaps = 7/171 (4%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
+ + S VG S L C ++G P I W ++ + L L +GSL I +
Sbjct: 3030 QGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ---NGSLTIHR 3086
Query: 311 VTTTHVGNYTCYADGYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPK 369
G Y C A+ V + + V PV +V P+ G +LRC A G P
Sbjct: 3087 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 3146
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
P + WL+ G + + S++L +GS + + NV D G Y C+A N G
Sbjct: 3147 PTIEWLQAGQPL--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 3194
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/203 (28%), Positives = 89/203 (43%), Gaps = 14/203 (6%)
Query: 237 EFYRAFQVIQLSLPEDQKLSITA---ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 293
+F AF++ LS E+ + +T A L C P + W R + L+ D
Sbjct: 1547 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 1604
Query: 294 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAR 352
+++ L I V + G Y+C A H V PPVI E
Sbjct: 1605 --EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 1662
Query: 353 EPGV----TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDT 408
E V T SL+C A G P P + WL+NG+ +P S +L + +G + +S D
Sbjct: 1663 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 1720
Query: 409 GAYTCIAKNEAGVDEDISSLFVE 431
+Y C+A+N+AG E + +L V+
Sbjct: 1721 ASYMCVAENQAGSAEKLFTLRVQ 1743
Score = 64.3 bits (155), Expect = 5e-10
Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 10/164 (6%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIIL--NNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
G LSC +G P I W+++ L L+ ++ G LY+ + G YT
Sbjct: 986 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQEGTYT 1043
Query: 321 CYADGYE-QVYQTHIFQVNVPPVI---RVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 376
C Q +V+VPP I R P + A+L C+A G P P + W +
Sbjct: 1044 CECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 1103
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+G + +L QL Q G +H+ + TG Y+C+A+N AG
Sbjct: 1104 DGQPVGAELGLQL--QNQGQSLHVERAQAAHTGRYSCVAENLAG 1145
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/188 (27%), Positives = 81/188 (43%), Gaps = 14/188 (7%)
Query: 248 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 307
+LP D+ L + G L CA +G+ P I W N+ + E +++ +L
Sbjct: 2942 TLPGDRSLRL-----GDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQ 2992
Query: 308 ITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAREP-GVTASLRCHAE 365
V+ G Y C+A+ Q F V PV++ S EP G + L C
Sbjct: 2993 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 3052
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
G P P + W+K+G+ P L Q + I +D G Y C+A+NE GV + +
Sbjct: 3053 GDPVPDIHWIKDGL---PLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKV 3109
Query: 426 SSLFVEDS 433
L ++ +
Sbjct: 3110 VILVLQSA 3117
Score = 60.5 bits (145), Expect = 7e-09
Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 12/164 (7%)
Query: 265 SAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYAD 324
S L C G P + W + + +++ + D L I + + G+Y C A
Sbjct: 711 SVTLECLASGVPPPDVSWFKGHQPVSSW--MGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 768
Query: 325 GYEQVYQTHI-FQVNVPPVIRVYPESQAREPG-----VTASLRCHAEGIPKPQLGWLKNG 378
+ +VNVPP I + P PG L C+A G P P L WLK+G
Sbjct: 769 NVAGSTELRYGLRVNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDG 824
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
++P + L + G + +++ R D+G Y+C+A + G D
Sbjct: 825 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 868
Score = 60.1 bits (144), Expect = 8e-09
Identities = 41/134 (30%), Positives = 60/134 (44%), Gaps = 3/134 (2%)
Query: 306 LYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHA 364
L I KV G YTC A + + +V VPP I P ++A + +L C A
Sbjct: 659 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 718
Query: 365 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDED 424
G+P P + W K ++ + +T+ +G + I + D G+Y C+A N AG E
Sbjct: 719 SGVPPPDVSWFKGHQPVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 776
Query: 425 ISSLFVEDSARKTL 438
L V R TL
Sbjct: 777 RYGLRVNVPPRITL 790
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/165 (29%), Positives = 69/165 (41%), Gaps = 20/165 (12%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G L C +G P + W ++ L + LE SL + V G Y+C
Sbjct: 2230 GSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ------GPSLQLEAVGAGDSGTYSCV 2283
Query: 323 ADGYEQVYQTHIFQVNV--PPVIRV--YPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 378
A + H FQ+ V PP I P + PG L C A+G P+P + W K+G
Sbjct: 2284 AVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2342
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+T L+ N + VR D G YTC+A++ AG E
Sbjct: 2343 QALT-------RLENNSRATRVLRVR--DAGLYTCLAESPAGAIE 2378
Score = 57.8 bits (138), Expect = 4e-08
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 3/161 (1%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
+V Q+A+L C G P + W+++ + L+ + +GSL I V G+Y
Sbjct: 2494 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRF--EILPEGSLRIQPVLAQDAGHYL 2551
Query: 321 CYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
C A Q +V PP I P + A L C A G PKP + W K+G
Sbjct: 2552 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQ 2611
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ +L + + + ++ +D+ + C+ NE G
Sbjct: 2612 KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 2652
Score = 57.4 bits (137), Expect = 6e-08
Identities = 55/215 (25%), Positives = 82/215 (38%), Gaps = 24/215 (11%)
Query: 234 ALEEFYRAFQVIQLSLP------EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNI 287
A+ E + FQ+ L P ED TV L C P I W ++
Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389
Query: 288 ILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRV 345
+I L I G YTC E V H+ +V +PP I
Sbjct: 1390 PFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHV-EVLIPPSIS- 1445
Query: 346 YPESQAREPGV---------TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 396
+ E GV T +L C + +P P + W K+G +TP S +L + G
Sbjct: 1446 -KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGR 1502
Query: 397 EVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ I + D+G Y C+A N AG D+ ++ ++
Sbjct: 1503 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 1537
Score = 56.6 bits (135), Expect = 9e-08
Identities = 38/157 (24%), Positives = 68/157 (43%), Gaps = 3/157 (1%)
Query: 268 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGY 326
L+C G P ++W ++ ++ + F L + + G Y+C A
Sbjct: 806 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 865
Query: 327 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 386
+ Q + QV++PP I + + + +L C + +P P L W K+G + P+
Sbjct: 866 GEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 925
Query: 387 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
L+ A+ + + + D G YTC A N+AG E
Sbjct: 926 VHLS--ADKALLQVDRADVWDAGHYTCEALNQAGRSE 960
Score = 55.8 bits (133), Expect = 2e-07
Identities = 47/169 (27%), Positives = 69/169 (40%), Gaps = 11/169 (6%)
Query: 257 ITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LYITKVTTTH 315
+ A G+ L C +G P + W + + + + DGS L +
Sbjct: 414 VVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET---DGSVLRLESPGEAS 470
Query: 316 VGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPE--SQAREPGVTASLRCHAEGIPKPQ 371
G Y+C A E V Q + +V VPP + V G L C A G P P
Sbjct: 471 SGLYSCVASSPAGEAVLQYSV-EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT 529
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ WL+NG Q+ Q G+ +HI +V + +G + C A NEAG
Sbjct: 530 IQWLQNGRPAEELAGVQVASQ--GTTLHIDHVELDHSGLFACQATNEAG 576
Score = 55.1 bits (131), Expect = 3e-07
Identities = 62/244 (25%), Positives = 97/244 (39%), Gaps = 33/244 (13%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTHVGN-- 318
G L C G P + W ++ ++ L+ +DG + ++T +HVG+
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ----VQEDGQ--VLRITGSHVGDEG 285
Query: 319 -YTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLG 373
Y C A Q FQ+ V ++ ++ E V L C A G+P P +
Sbjct: 286 RYQCVAFS-PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT 344
Query: 374 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 433
W K+G + S ++ G ++ + + D G YTC A N G E + L V
Sbjct: 345 WFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV--Y 400
Query: 434 ARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKA 493
T+ EG G G + V G V +EC + H P+ L + E P A
Sbjct: 401 VPPTI-------EGAG-GRPYVVKAVAGRPV--ALECVARGHPSPT---LSWHHEGLPVA 447
Query: 494 EGDE 497
E +E
Sbjct: 448 ESNE 451
Score = 52.8 bits (125), Expect = 1e-06
Identities = 50/204 (24%), Positives = 78/204 (38%), Gaps = 34/204 (16%)
Query: 248 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN----------NLDLEDI 297
S+ ED + + + GQS L C G P I+W ++ ++ +L +
Sbjct: 96 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 155
Query: 298 NDFG--DDG-SLYITKVTTTHVGNYTCYADG--------------YEQVYQTHIFQVNVP 340
D+G SL+ ++ G A G +EQ H F P
Sbjct: 156 GGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAP 215
Query: 341 PVIRVYPESQARE----PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 396
P V A+E G L+C G+P PQ+ W K+ + P L +Q +G
Sbjct: 216 P--SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQ 272
Query: 397 EVHISNVRYEDTGAYTCIAKNEAG 420
+ I+ D G Y C+A + AG
Sbjct: 273 VLRITGSHVGDEGRYQCVAFSPAG 296
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/173 (24%), Positives = 67/173 (38%), Gaps = 6/173 (3%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 309
P L++TA T A+L C G+ +P ++W ++ L+ + +L +T
Sbjct: 2577 PSPSNLTLTAHT---PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLT 2633
Query: 310 KVTTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 368
+ C + ++ + V+VPP I L CH+ GIP
Sbjct: 2634 APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIP 2693
Query: 369 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 421
P + W K G + + S + E I G YTC A+N AGV
Sbjct: 2694 APTVSWSKAGAQLGARGSGYRVSPSGALE--IGQALPIHAGRYTCSARNSAGV 2744
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 8/183 (4%)
Query: 252 DQKLSITAATVGQSAVLS--CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 309
D + + TV S+ +S C G P I W +N + + + + G L ++
Sbjct: 1656 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVS 1713
Query: 310 KVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREP-GVTASLRCHAEGI 367
+Y C A+ + +V VPP I Q + SL C
Sbjct: 1714 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAH 1773
Query: 368 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISS 427
P P++ W K+ ++ L +++ L + + R D+G YTC A N AG D+ +
Sbjct: 1774 PNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1831
Query: 428 LFV 430
L V
Sbjct: 1832 LSV 1834
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 9/171 (5%)
Query: 255 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 314
L A + S L C + P + W +++ L+ E++ +L + + +
Sbjct: 1753 LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLS 1810
Query: 315 HVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYP----ESQAREPGVTASLRCHAEGIPK 369
G YTC A Q + V VPP R P ++ G A L C + +P+
Sbjct: 1811 DSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1870
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
P + W K+G + L+++ G + I + D G Y+C N AG
Sbjct: 1871 PTVTWYKDGQPLV--LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 1919
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 16/164 (9%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
T G L C QGT +P I W ++ L L ++ S + G YT
Sbjct: 2317 TPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGLYT 2367
Query: 321 CYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS---LRCHAEGIPKPQLGWLK 376
C A+ + ++ +V PP I V P G+ L C E P P++ W +
Sbjct: 2368 CLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 2426
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+GI + Q G + + + D+G Y+C A+N AG
Sbjct: 2427 DGIVLQEDAHTQ--FPERGRFLQLQALSTADSGDYSCTARNAAG 2468
Score = 49.3 bits (116), Expect = 2e-05
Identities = 44/186 (23%), Positives = 76/186 (40%), Gaps = 16/186 (8%)
Query: 244 VIQLSLP-----EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN 298
V+Q+ +P E+ +S+ A +S L C P + W ++ L ++
Sbjct: 873 VLQVHMPPSILGEELNVSVVA---NESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVH 927
Query: 299 DFGDDGSLYITKVTTTHVGNYTC----YADGYEQVYQTHIFQVNVPPVIRVYPESQAREP 354
D L + + G+YTC A E+ Y +++ V P +R RE
Sbjct: 928 LSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFP-LRESHTLTVRE- 985
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
G SL C G+P P++ W K+G + + + + A G +++ + G YTC
Sbjct: 986 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 1045
Query: 415 AKNEAG 420
N G
Sbjct: 1046 CSNVVG 1051
Score = 47.8 bits (112), Expect = 4e-05
Identities = 50/189 (26%), Positives = 76/189 (40%), Gaps = 13/189 (6%)
Query: 240 RAFQVIQLSLPE-----DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDL 294
R F++ L PE D +ITAA + L C G P I W R ++
Sbjct: 1149 RKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PG 1205
Query: 295 EDINDFGDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE 353
ED L +T+ G Y+C A + + +V VPP I + +
Sbjct: 1206 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 1265
Query: 354 --PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 411
G TA L C+ G P+P+L W K+G + + ++ +G + + G Y
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHY 1323
Query: 412 TCIAKNEAG 420
+CIA N G
Sbjct: 1324 SCIAANAVG 1332
Score = 43.9 bits (102), Expect = 6e-04
Identities = 37/130 (28%), Positives = 57/130 (43%), Gaps = 5/130 (3%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
E + L A TVG A C GT +P + W++ L + ++GSL++
Sbjct: 6 EIKGLGDVALTVGLEAG-GCGTHGTPKPQVTWRKGPSS-EPLHGQPGVAVLEEGSLFLAS 63
Query: 311 VTTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRV--YPESQAREPGVTASLRCHAEGI 367
V+ G+Y C A + V VPP IR + + G + +L C A G
Sbjct: 64 VSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGF 123
Query: 368 PKPQLGWLKN 377
P P++ WLK+
Sbjct: 124 PVPEIVWLKD 133
Score = 33.5 bits (75), Expect = 0.85
Identities = 19/59 (32%), Positives = 26/59 (44%), Gaps = 1/59 (1%)
Query: 362 CHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
C G PKPQ+ W K G P + + +++V D+G Y C A NE G
Sbjct: 24 CGTHGTPKPQVTWRK-GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 81
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 83.2 bits (204), Expect = 9e-16
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 9/185 (4%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
E+ K + G VL+C + G P + W ++ + + + + + G G L +++
Sbjct: 3127 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG--GRLQLSR 3184
Query: 311 VTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE----PGVTASLRCHAE 365
+ G YTC A+ + + + + V V P IR ARE G L C A+
Sbjct: 3185 LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIR--SSGVAREHHVLEGQEVRLDCEAD 3242
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
G P P + WLK+G + + L +G + + +R D GAYTC+A N AG D +
Sbjct: 3243 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL 3302
Query: 426 SSLFV 430
++ V
Sbjct: 3303 HTVNV 3307
Score = 76.3 bits (186), Expect = 1e-13
Identities = 55/188 (29%), Positives = 82/188 (43%), Gaps = 11/188 (5%)
Query: 237 EFYRAFQV---IQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 293
E +R +QV + ++ +DQ + T+ VL+C G P + W + L
Sbjct: 3844 EAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 3901
Query: 294 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAR 352
G+L I + H G YTC A V H+F V PV++ P
Sbjct: 3902 SG--YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA 3959
Query: 353 EPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYT 412
L C A GIP+P + W K G+++ +S Q+ G ++ I++ ED G Y
Sbjct: 3960 VAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV---LPGGQLRIAHASPEDAGNYL 4016
Query: 413 CIAKNEAG 420
CIAKN AG
Sbjct: 4017 CIAKNSAG 4024
Score = 73.6 bits (179), Expect = 7e-13
Identities = 49/173 (28%), Positives = 78/173 (45%), Gaps = 6/173 (3%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
GQ L C G P + W ++ L + + D GSL + + + G YTC
Sbjct: 3232 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 3291
Query: 323 ADGYE-QVYQTHIFQVNVPPVIRVYPESQAR---EPGVTASLRCHAEGIPKPQLGWLKNG 378
A + + H V VPP I+ + PG ++ C G P + WLK+G
Sbjct: 3292 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG 3351
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ + LS++ L +G + IS V+ D G +TC+A + AGV + +L V+
Sbjct: 3352 LPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ 3402
Score = 70.9 bits (172), Expect = 5e-12
Identities = 51/191 (26%), Positives = 84/191 (43%), Gaps = 7/191 (3%)
Query: 244 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD 303
V+Q+ + L + T G A L C +G+ P I W ++ ++ E
Sbjct: 4033 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA--EGKFTIQPS 4090
Query: 304 GSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRC 362
G L + + G YTC A+ + + + V PV P ++ G LRC
Sbjct: 4091 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRC 4150
Query: 363 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
A G P P++GW N +T +S+ Q GS + + V ED+G Y C A+N G
Sbjct: 4151 AARGSPTPRIGWTVNDRPVTEGVSE----QDGGSTLQRAAVSREDSGTYVCWAENRVGRT 4206
Query: 423 EDISSLFVEDS 433
+ +S + V+++
Sbjct: 4207 QAVSFVHVKEA 4217
Score = 70.1 bits (170), Expect = 8e-12
Identities = 64/244 (26%), Positives = 105/244 (43%), Gaps = 28/244 (11%)
Query: 240 RAFQVIQLSLPEDQKLSITAATV--GQSAVLSCAIQGTLRPPIIWKRNNIIL-----NNL 292
RA I ++ P Q + TV G++AVLSC + G + W R+ +L
Sbjct: 506 RAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVA 565
Query: 293 DLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQ-VNVPPVIRVYPESQA 351
L D+ SL I+ + T G Y C A V + ++ V P + ++ SQ
Sbjct: 566 QLADL-------SLEISGIIPTDGGRYQCVASNANGVTRASVWLLVREAPQVSIHTSSQH 618
Query: 352 REPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 411
GV + C A G P P + W + + ++ + A G+ + I V ED G Y
Sbjct: 619 FSQGVEVKVSCSASGYPTPHISWSRESQALQE--DSRIHVDAQGTLI-IQGVAPEDAGNY 675
Query: 412 TCIAKNEAGVDEDISSLFVED----SARKTLANILWREEGL------GIGNMFYVFYEDG 461
+C A NE G D++ +L+ D SA + + EE + G+ ++Y G
Sbjct: 676 SCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 735
Query: 462 IKVI 465
+++I
Sbjct: 736 LEMI 739
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/159 (30%), Positives = 77/159 (48%), Gaps = 9/159 (5%)
Query: 267 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN-DFGDDGS-LYITKVTTTHVGNYTCYA- 323
VL C+++ P I W R+ I+L ED + F + G L + ++T G+Y+C A
Sbjct: 3600 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 3655
Query: 324 DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP 383
+ +++ P IR P + TA L C A+G+P P + W K+ + + P
Sbjct: 3656 NAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP 3715
Query: 384 KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
+ S + + GS + I V +D G Y C+A N AG D
Sbjct: 3716 R-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 3752
Score = 68.9 bits (167), Expect = 2e-11
Identities = 50/171 (29%), Positives = 75/171 (43%), Gaps = 7/171 (4%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
+ + S VG S L C ++G P I W ++ + L L +GSL I +
Sbjct: 4221 QGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ---NGSLTIHR 4277
Query: 311 VTTTHVGNYTCYADGYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPK 369
G Y C A+ V + + V PV +V P+ G +LRC A G P
Sbjct: 4278 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 4337
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
P + WL+ G + + S++L +GS + + NV D G Y C+A N G
Sbjct: 4338 PTIEWLQAGQPL--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 4385
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/203 (28%), Positives = 89/203 (43%), Gaps = 14/203 (6%)
Query: 237 EFYRAFQVIQLSLPEDQKLSITA---ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 293
+F AF++ LS E+ + +T A L C P + W R + L+ D
Sbjct: 2738 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 2795
Query: 294 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAR 352
+++ L I V + G Y+C A H V PPVI E
Sbjct: 2796 --EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 2853
Query: 353 EPGV----TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDT 408
E V T SL+C A G P P + WL+NG+ +P S +L + +G + +S D
Sbjct: 2854 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 2911
Query: 409 GAYTCIAKNEAGVDEDISSLFVE 431
+Y C+A+N+AG E + +L V+
Sbjct: 2912 ASYMCVAENQAGSAEKLFTLRVQ 2934
Score = 65.9 bits (159), Expect = 2e-10
Identities = 48/152 (31%), Positives = 63/152 (41%), Gaps = 16/152 (10%)
Query: 303 DGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLR 361
DGSL++ + H G Y+C A + V VPP I GV ASL
Sbjct: 937 DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLP 996
Query: 362 CHAEGIPKPQLGWLKNGIDITPK-----LSKQLTLQANGSEVHISNVRYEDTGAYTCIAK 416
C A G+P P + W K +T + +SK+ TL I+ +D GAY C A
Sbjct: 997 CVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-------IAQPSAQDAGAYVCTAT 1049
Query: 417 NEAGVDEDISSLFVEDSARKTLANILWREEGL 448
N G L V R L+ +W E GL
Sbjct: 1050 NTVGFSSQEMRLSVN---RLALSKYVWEEYGL 1078
Score = 65.9 bits (159), Expect = 2e-10
Identities = 42/122 (34%), Positives = 55/122 (45%), Gaps = 13/122 (10%)
Query: 304 GSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRC 362
GSL + +V G+Y C A ++ V VPP ++ P G L C
Sbjct: 1082 GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNC 1141
Query: 363 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE--VHISNVRYEDTGAYTCIAKNEAG 420
AEG P+PQL W K+G+ LQ G + VH + +R D G Y C A N AG
Sbjct: 1142 VAEGNPEPQLSWSKDGV----------VLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAG 1191
Query: 421 VD 422
VD
Sbjct: 1192 VD 1193
Score = 64.3 bits (155), Expect = 5e-10
Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 10/164 (6%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIIL--NNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
G LSC +G P I W+++ L L+ ++ G LY+ + G YT
Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQEGTYT 2234
Query: 321 CYADGYE-QVYQTHIFQVNVPPVI---RVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 376
C Q +V+VPP I R P + A+L C+A G P P + W +
Sbjct: 2235 CECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 2294
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+G + +L QL Q G +H+ + TG Y+C+A+N AG
Sbjct: 2295 DGQPVGAELGLQL--QNQGQSLHVERAQAAHTGRYSCVAENLAG 2336
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/188 (27%), Positives = 81/188 (43%), Gaps = 14/188 (7%)
Query: 248 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 307
+LP D+ L + G L CA +G+ P I W N+ + E +++ +L
Sbjct: 4133 TLPGDRSLRL-----GDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQ 4183
Query: 308 ITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAREP-GVTASLRCHAE 365
V+ G Y C+A+ Q F V PV++ S EP G + L C
Sbjct: 4184 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 4243
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
G P P + W+K+G+ P L Q + I +D G Y C+A+NE GV + +
Sbjct: 4244 GDPVPDIHWIKDGL---PLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKV 4300
Query: 426 SSLFVEDS 433
L ++ +
Sbjct: 4301 VILVLQSA 4308
Score = 62.8 bits (151), Expect = 1e-09
Identities = 46/162 (28%), Positives = 68/162 (41%), Gaps = 12/162 (7%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
VG++ L+C +G P + W ++ ++L G GS++ + T+ G Y C
Sbjct: 1133 VGEALDLNCVAEGNPEPQLSWSKDGVVLQGR--------GPQGSVHFAAIRTSDAGRYRC 1184
Query: 322 YADGYEQVYQTHI-FQVNVPPVIRVYPESQARE--PGVTASLRCHAEGIPKPQLGWLKNG 378
A V + +V PP S E G ASL C A G PKPQ+ W K G
Sbjct: 1185 EASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRK-G 1243
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
P + + +++V D+G Y C A NE G
Sbjct: 1244 PSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVG 1285
Score = 60.5 bits (145), Expect = 7e-09
Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 12/164 (7%)
Query: 265 SAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYAD 324
S L C G P + W + + +++ + D L I + + G+Y C A
Sbjct: 1902 SVTLECLASGVPPPDVSWFKGHQPVSSW--MGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 1959
Query: 325 GYEQVYQTHI-FQVNVPPVIRVYPESQAREPG-----VTASLRCHAEGIPKPQLGWLKNG 378
+ +VNVPP I + P PG L C+A G P P L WLK+G
Sbjct: 1960 NVAGSTELRYGLRVNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDG 2015
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
++P + L + G + +++ R D+G Y+C+A + G D
Sbjct: 2016 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 2059
Score = 60.1 bits (144), Expect = 8e-09
Identities = 41/134 (30%), Positives = 60/134 (44%), Gaps = 3/134 (2%)
Query: 306 LYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHA 364
L I KV G YTC A + + +V VPP I P ++A + +L C A
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 1909
Query: 365 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDED 424
G+P P + W K ++ + +T+ +G + I + D G+Y C+A N AG E
Sbjct: 1910 SGVPPPDVSWFKGHQPVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 1967
Query: 425 ISSLFVEDSARKTL 438
L V R TL
Sbjct: 1968 RYGLRVNVPPRITL 1981
Score = 59.7 bits (143), Expect = 1e-08
Identities = 47/185 (25%), Positives = 79/185 (42%), Gaps = 17/185 (9%)
Query: 252 DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
D+ + G++A L C +GT +P + W++ L + ++GSL++ V
Sbjct: 1210 DETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSS-EPLHGQPGVAVLEEGSLFLASV 1268
Query: 312 TTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRV--YPESQAREPGVTASLRCHAEGIP 368
+ G+Y C A + V VPP IR + + G + +L C A G P
Sbjct: 1269 SPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFP 1328
Query: 369 KPQLGWLKN-------------GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
P++ WLK+ G D+ L G +H ++ D+G Y+C A
Sbjct: 1329 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA 1388
Query: 416 KNEAG 420
+N+AG
Sbjct: 1389 ENQAG 1393
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/165 (29%), Positives = 69/165 (41%), Gaps = 20/165 (12%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G L C +G P + W ++ L + LE SL + V G Y+C
Sbjct: 3421 GSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ------GPSLQLEAVGAGDSGTYSCV 3474
Query: 323 ADGYEQVYQTHIFQVNV--PPVIRV--YPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 378
A + H FQ+ V PP I P + PG L C A+G P+P + W K+G
Sbjct: 3475 AVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 3533
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+T L+ N + VR D G YTC+A++ AG E
Sbjct: 3534 QALT-------RLENNSRATRVLRVR--DAGLYTCLAESPAGAIE 3569
Score = 57.8 bits (138), Expect = 4e-08
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 3/161 (1%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
+V Q+A+L C G P + W+++ + L+ + +GSL I V G+Y
Sbjct: 3685 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRF--EILPEGSLRIQPVLAQDAGHYL 3742
Query: 321 CYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
C A Q +V PP I P + A L C A G PKP + W K+G
Sbjct: 3743 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQ 3802
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ +L + + + ++ +D+ + C+ NE G
Sbjct: 3803 KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 3843
Score = 57.4 bits (137), Expect = 6e-08
Identities = 55/215 (25%), Positives = 82/215 (38%), Gaps = 24/215 (11%)
Query: 234 ALEEFYRAFQVIQLSLP------EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNI 287
A+ E + FQ+ L P ED TV L C P I W ++
Sbjct: 2521 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 2580
Query: 288 ILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRV 345
+I L I G YTC E V H+ +V +PP I
Sbjct: 2581 PFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHV-EVLIPPSIS- 2636
Query: 346 YPESQAREPGV---------TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 396
+ E GV T +L C + +P P + W K+G +TP S +L + G
Sbjct: 2637 -KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGR 2693
Query: 397 EVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ I + D+G Y C+A N AG D+ ++ ++
Sbjct: 2694 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 2728
Score = 57.0 bits (136), Expect = 7e-08
Identities = 49/165 (29%), Positives = 67/165 (40%), Gaps = 21/165 (12%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGD-DGSLYITKVTTTHVGNYTC 321
G +SC+ G P I W R + L ED D G+L I V GNY+C
Sbjct: 622 GVEVKVSCSASGYPTPHISWSRESQALQ----EDSRIHVDAQGTLIIQGVAPEDAGNYSC 677
Query: 322 YAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 378
A G +Q +T PP + G A L C A G+P P++ W + G
Sbjct: 678 QATNEVGTDQ--ETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGG 735
Query: 379 IDITPKLSKQLTLQANGS---EVHISNVRYEDTGAYTCIAKNEAG 420
++ + L GS ++ I + D G YTC A NE G
Sbjct: 736 LE--------MILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELG 772
Score = 57.0 bits (136), Expect = 7e-08
Identities = 46/189 (24%), Positives = 78/189 (41%), Gaps = 17/189 (8%)
Query: 248 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN----------NLDLEDI 297
S+ ED + + + GQS L C G P I+W ++ ++ +L +
Sbjct: 1300 SIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQV 1359
Query: 298 NDFG--DDG-SLYITKVTTTHVGNYTCYADGYEQVYQT--HIFQVNVPPVIRVYPESQAR 352
D+G SL+ ++ G Y+C A+ Q H+ + P V+ +
Sbjct: 1360 GGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVL 1419
Query: 353 E-PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 411
G L+C G+P PQ+ W K+ + P L +Q +G + I+ D G Y
Sbjct: 1420 GLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQVLRITGSHVGDEGRY 1478
Query: 412 TCIAKNEAG 420
C+A + AG
Sbjct: 1479 QCVAFSPAG 1487
Score = 56.6 bits (135), Expect = 9e-08
Identities = 38/157 (24%), Positives = 68/157 (43%), Gaps = 3/157 (1%)
Query: 268 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGY 326
L+C G P ++W ++ ++ + F L + + G Y+C A
Sbjct: 1997 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 2056
Query: 327 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 386
+ Q + QV++PP I + + + +L C + +P P L W K+G + P+
Sbjct: 2057 GEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 2116
Query: 387 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
L+ A+ + + + D G YTC A N+AG E
Sbjct: 2117 VHLS--ADKALLQVDRADVWDAGHYTCEALNQAGHSE 2151
Score = 55.8 bits (133), Expect = 2e-07
Identities = 47/169 (27%), Positives = 69/169 (40%), Gaps = 11/169 (6%)
Query: 257 ITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LYITKVTTTH 315
+ A G+ L C +G P + W + + + + DGS L +
Sbjct: 1605 VVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET---DGSVLRLESPGEAS 1661
Query: 316 VGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPE--SQAREPGVTASLRCHAEGIPKPQ 371
G Y+C A E V Q + +V VPP + V G L C A G P P
Sbjct: 1662 SGLYSCVASSPAGEAVLQYSV-EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT 1720
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ WL+NG Q+ Q G+ +HI +V + +G + C A NEAG
Sbjct: 1721 IQWLQNGRPAEELAGVQVASQ--GTTLHIDHVELDHSGLFACQATNEAG 1767
Score = 55.1 bits (131), Expect = 3e-07
Identities = 56/199 (28%), Positives = 83/199 (41%), Gaps = 15/199 (7%)
Query: 234 ALEEFYRAFQVIQLSLPEDQKLSITAATV----GQSAVLSCAIQGTLRPPIIWKRNNIIL 289
A+ E A IQL++ +L+ V G+SA+L+C G P + W+R +
Sbjct: 767 AVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQP 826
Query: 290 NNLDL----EDINDFGDDGSLYITKVTTTHVGNYTCYAD---GYEQVYQTHIFQVNVPPV 342
L L + D G L+ V Y C A G Q I + PP
Sbjct: 827 LGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQ 886
Query: 343 IRVYPESQAREPGVTASLRCHA-EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHIS 401
I + G SL C G P P+ WLK+G + P + +++A+GS +H+
Sbjct: 887 IASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP--GSRHSIRADGS-LHLD 943
Query: 402 NVRYEDTGAYTCIAKNEAG 420
E G Y+C+A N AG
Sbjct: 944 RALQEHAGRYSCVATNTAG 962
Score = 55.1 bits (131), Expect = 3e-07
Identities = 62/244 (25%), Positives = 97/244 (39%), Gaps = 33/244 (13%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTHVGN-- 318
G L C G P + W ++ ++ L+ +DG + ++T +HVG+
Sbjct: 1423 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ----VQEDGQ--VLRITGSHVGDEG 1476
Query: 319 -YTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLG 373
Y C A Q FQ+ V ++ ++ E V L C A G+P P +
Sbjct: 1477 RYQCVAFS-PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT 1535
Query: 374 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 433
W K+G + S ++ G ++ + + D G YTC A N G E + L V
Sbjct: 1536 WFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV--Y 1591
Query: 434 ARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKA 493
T+ EG G G + V G V +EC + H P+ L + E P A
Sbjct: 1592 VPPTI-------EGAG-GRPYVVKAVAGRPV--ALECVARGHPSPT---LSWHHEGLPVA 1638
Query: 494 EGDE 497
E +E
Sbjct: 1639 ESNE 1642
Score = 52.4 bits (124), Expect = 2e-06
Identities = 49/190 (25%), Positives = 72/190 (37%), Gaps = 10/190 (5%)
Query: 256 SITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH 315
++ VG+ AVL C G P +IW R L++ + G L I
Sbjct: 705 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGG-----LEMILAPEGSSSGKLRIPAAQERD 759
Query: 316 VGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 374
G YTC A I V P + P E G +A L C A G P P + W
Sbjct: 760 AGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW 819
Query: 375 LK-NGIDITPKLSK---QLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
+ +G + +L + Q + + +V ED Y C A+N G + + L V
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Query: 431 EDSARKTLAN 440
A +A+
Sbjct: 880 TGHAPPQIAS 889
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/173 (24%), Positives = 67/173 (38%), Gaps = 6/173 (3%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 309
P L++TA T A+L C G+ +P ++W ++ L+ + +L +T
Sbjct: 3768 PSPSNLTLTAHT---PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLT 3824
Query: 310 KVTTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 368
+ C + ++ + V+VPP I L CH+ GIP
Sbjct: 3825 APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIP 3884
Query: 369 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 421
P + W K G + + S + E I G YTC A+N AGV
Sbjct: 3885 APTVSWSKAGAQLGARGSGYRVSPSGALE--IGQALPIHAGRYTCSARNSAGV 3935
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 8/183 (4%)
Query: 252 DQKLSITAATVGQSAVLS--CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 309
D + + TV S+ +S C G P I W +N + + + + G L ++
Sbjct: 2847 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVS 2904
Query: 310 KVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREP-GVTASLRCHAEGI 367
+Y C A+ + +V VPP I Q + SL C
Sbjct: 2905 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAH 2964
Query: 368 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISS 427
P P++ W K+ ++ L +++ L + + R D+G YTC A N AG D+ +
Sbjct: 2965 PNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 3022
Query: 428 LFV 430
L V
Sbjct: 3023 LSV 3025
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 9/171 (5%)
Query: 255 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 314
L A + S L C + P + W +++ L+ E++ +L + + +
Sbjct: 2944 LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLS 3001
Query: 315 HVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYP----ESQAREPGVTASLRCHAEGIPK 369
G YTC A Q + V VPP R P ++ G A L C + +P+
Sbjct: 3002 DSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 3061
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
P + W K+G + L+++ G + I + D G Y+C N AG
Sbjct: 3062 PTVTWYKDGQPLV--LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 3110
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 16/164 (9%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
T G L C QGT +P I W ++ L L ++ S + G YT
Sbjct: 3508 TPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGLYT 3558
Query: 321 CYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS---LRCHAEGIPKPQLGWLK 376
C A+ + ++ +V PP I V P G+ L C E P P++ W +
Sbjct: 3559 CLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 3617
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+GI + Q G + + + D+G Y+C A+N AG
Sbjct: 3618 DGIVLQEDAHTQ--FPERGRFLQLQALSTADSGDYSCTARNAAG 3659
Score = 49.3 bits (116), Expect = 2e-05
Identities = 44/186 (23%), Positives = 76/186 (40%), Gaps = 16/186 (8%)
Query: 244 VIQLSLP-----EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN 298
V+Q+ +P E+ +S+ A +S L C P + W ++ L ++
Sbjct: 2064 VLQVHMPPSILGEELNVSVVA---NESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVH 2118
Query: 299 DFGDDGSLYITKVTTTHVGNYTC----YADGYEQVYQTHIFQVNVPPVIRVYPESQAREP 354
D L + + G+YTC A E+ Y +++ V P +R RE
Sbjct: 2119 LSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-LRESHTLTVRE- 2176
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
G SL C G+P P++ W K+G + + + + A G +++ + G YTC
Sbjct: 2177 GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 2236
Query: 415 AKNEAG 420
N G
Sbjct: 2237 CSNVVG 2242
Score = 47.8 bits (112), Expect = 4e-05
Identities = 50/189 (26%), Positives = 76/189 (40%), Gaps = 13/189 (6%)
Query: 240 RAFQVIQLSLPE-----DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDL 294
R F++ L PE D +ITAA + L C G P I W R ++
Sbjct: 2340 RKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PG 2396
Query: 295 EDINDFGDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE 353
ED L +T+ G Y+C A + + +V VPP I + +
Sbjct: 2397 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 2456
Query: 354 --PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 411
G TA L C+ G P+P+L W K+G + + ++ +G + + G Y
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHY 2514
Query: 412 TCIAKNEAG 420
+CIA N G
Sbjct: 2515 SCIAANAVG 2523
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 83.2 bits (204), Expect = 9e-16
Identities = 51/185 (27%), Positives = 85/185 (45%), Gaps = 9/185 (4%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
E+ K + G VL+C + G P + W ++ + + + + + G G L +++
Sbjct: 1845 ENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRG--GRLQLSR 1902
Query: 311 VTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE----PGVTASLRCHAE 365
+ G YTC A+ + + + + V V P IR ARE G L C A+
Sbjct: 1903 LQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIR--SSGVAREHHVLEGQEVRLDCEAD 1960
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
G P P + WLK+G + + L +G + + +R D GAYTC+A N AG D +
Sbjct: 1961 GQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARL 2020
Query: 426 SSLFV 430
++ V
Sbjct: 2021 HTVNV 2025
Score = 76.3 bits (186), Expect = 1e-13
Identities = 55/188 (29%), Positives = 82/188 (43%), Gaps = 11/188 (5%)
Query: 237 EFYRAFQV---IQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 293
E +R +QV + ++ +DQ + T+ VL+C G P + W + L
Sbjct: 2562 EAHRLYQVTVHVPPTIADDQ--TDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARG 2619
Query: 294 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAR 352
G+L I + H G YTC A V H+F V PV++ P
Sbjct: 2620 SG--YRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRA 2677
Query: 353 EPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYT 412
L C A GIP+P + W K G+++ +S Q+ G ++ I++ ED G Y
Sbjct: 2678 VAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQV---LPGGQLRIAHASPEDAGNYL 2734
Query: 413 CIAKNEAG 420
CIAKN AG
Sbjct: 2735 CIAKNSAG 2742
Score = 73.6 bits (179), Expect = 7e-13
Identities = 49/173 (28%), Positives = 78/173 (45%), Gaps = 6/173 (3%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
GQ L C G P + W ++ L + + D GSL + + + G YTC
Sbjct: 1950 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCV 2009
Query: 323 ADGYE-QVYQTHIFQVNVPPVIRVYPESQAR---EPGVTASLRCHAEGIPKPQLGWLKNG 378
A + + H V VPP I+ + PG ++ C G P + WLK+G
Sbjct: 2010 AHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDG 2069
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ + LS++ L +G + IS V+ D G +TC+A + AGV + +L V+
Sbjct: 2070 LPLP--LSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ 2120
Score = 70.9 bits (172), Expect = 5e-12
Identities = 51/191 (26%), Positives = 84/191 (43%), Gaps = 7/191 (3%)
Query: 244 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD 303
V+Q+ + L + T G A L C +G+ P I W ++ ++ E
Sbjct: 2751 VVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGA--EGKFTIQPS 2808
Query: 304 GSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRC 362
G L + + G YTC A+ + + + V PV P ++ G LRC
Sbjct: 2809 GELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRC 2868
Query: 363 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
A G P P++GW N +T +S+ Q GS + + V ED+G Y C A+N G
Sbjct: 2869 AARGSPTPRIGWTVNDRPVTEGVSE----QDGGSTLQRAAVSREDSGTYVCWAENRVGRT 2924
Query: 423 EDISSLFVEDS 433
+ +S + V+++
Sbjct: 2925 QAVSFVHVKEA 2935
Score = 69.7 bits (169), Expect = 1e-11
Identities = 48/159 (30%), Positives = 77/159 (48%), Gaps = 9/159 (5%)
Query: 267 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN-DFGDDGS-LYITKVTTTHVGNYTCYA- 323
VL C+++ P I W R+ I+L ED + F + G L + ++T G+Y+C A
Sbjct: 2318 VLECSVEAEPAPKITWHRDGIVLQ----EDAHTQFPERGRFLQLQALSTADSGDYSCTAR 2373
Query: 324 DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP 383
+ +++ P IR P + TA L C A+G+P P + W K+ + + P
Sbjct: 2374 NAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDP 2433
Query: 384 KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
+ S + + GS + I V +D G Y C+A N AG D
Sbjct: 2434 R-SPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2470
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/171 (29%), Positives = 75/171 (43%), Gaps = 7/171 (4%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITK 310
+ + S VG S L C ++G P I W ++ + L L +GSL I +
Sbjct: 2939 QGEAFSYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQ---NGSLTIRR 2995
Query: 311 VTTTHVGNYTCYADGYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPK 369
G Y C A+ V + + V PV +V P+ G +LRC A G P
Sbjct: 2996 TERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPT 3055
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
P + WL+ G + + S++L +GS + + NV D G Y C+A N G
Sbjct: 3056 PTIEWLQAGQPL--RASRRLRTLPDGS-LWLENVETGDAGTYDCVAHNLLG 3103
Score = 68.2 bits (165), Expect = 3e-11
Identities = 58/203 (28%), Positives = 89/203 (43%), Gaps = 14/203 (6%)
Query: 237 EFYRAFQVIQLSLPEDQKLSITA---ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLD 293
+F AF++ LS E+ + +T A L C P + W R + L+ D
Sbjct: 1456 DFSAAFEI--LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 1513
Query: 294 LEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAR 352
+++ L I V + G Y+C A H V PPVI E
Sbjct: 1514 --EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVE 1571
Query: 353 EPGV----TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDT 408
E V T SL+C A G P P + WL+NG+ +P S +L + +G + +S D
Sbjct: 1572 EVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSP--SPRLQVLEDGQVLQVSTAEVADA 1629
Query: 409 GAYTCIAKNEAGVDEDISSLFVE 431
+Y C+A+N+AG E + +L V+
Sbjct: 1630 ASYMCVAENQAGSAEKLFTLRVQ 1652
Score = 63.9 bits (154), Expect = 6e-10
Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 10/164 (6%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIIL--NNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
G LSC +G P I W+++ L L+ ++ G LY+ + G YT
Sbjct: 895 GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR--LLYLGQAQLAQEGTYT 952
Query: 321 CYADGYE-QVYQTHIFQVNVPPVI---RVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 376
C Q +V+VPP I R P + A+L C+A G P P + W +
Sbjct: 953 CECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER 1012
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+G + +L QL Q G +H+ + TG Y+C+A+N AG
Sbjct: 1013 DGQPVGAELGLQL--QNQGQSLHVERAQAAHTGRYSCVAENLAG 1054
Score = 63.2 bits (152), Expect = 1e-09
Identities = 51/188 (27%), Positives = 81/188 (43%), Gaps = 14/188 (7%)
Query: 248 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 307
+LP D+ L + G L CA +G+ P I W N+ + E +++ +L
Sbjct: 2851 TLPGDRSLRL-----GDRLWLRCAARGSPTPRIGWTVNDRPVT----EGVSEQDGGSTLQ 2901
Query: 308 ITKVTTTHVGNYTCYADGYEQVYQTHIF-QVNVPPVIRVYPESQAREP-GVTASLRCHAE 365
V+ G Y C+A+ Q F V PV++ S EP G + L C
Sbjct: 2902 RAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVGGSIQLDCVVR 2961
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
G P P + W+K+G+ P L Q + I +D G Y C+A+NE GV + +
Sbjct: 2962 GDPVPDIHWIKDGL---PLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKV 3018
Query: 426 SSLFVEDS 433
L ++ +
Sbjct: 3019 VILVLQSA 3026
Score = 60.5 bits (145), Expect = 7e-09
Identities = 44/164 (26%), Positives = 71/164 (43%), Gaps = 12/164 (7%)
Query: 265 SAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYAD 324
S L C G P + W + + +++ + D L I + + G+Y C A
Sbjct: 620 SVTLECLASGVPPPDVSWFKGHQPVSSW--MGVTVSVDGRVLRIEQAQLSDAGSYRCVAS 677
Query: 325 GYEQVYQTHI-FQVNVPPVIRVYPESQAREPG-----VTASLRCHAEGIPKPQLGWLKNG 378
+ +VNVPP I + P PG L C+A G P P L WLK+G
Sbjct: 678 NVAGSTELRYGLRVNVPPRITLPPSL----PGPVLVNTPVRLTCNATGAPSPTLMWLKDG 733
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
++P + L + G + +++ R D+G Y+C+A + G D
Sbjct: 734 NPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGED 777
Score = 60.1 bits (144), Expect = 8e-09
Identities = 41/134 (30%), Positives = 60/134 (44%), Gaps = 3/134 (2%)
Query: 306 LYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHA 364
L I KV G YTC A + + +V VPP I P ++A + +L C A
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLA 627
Query: 365 EGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDED 424
G+P P + W K ++ + +T+ +G + I + D G+Y C+A N AG E
Sbjct: 628 SGVPPPDVSWFKGHQPVSSWMG--VTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTEL 685
Query: 425 ISSLFVEDSARKTL 438
L V R TL
Sbjct: 686 RYGLRVNVPPRITL 699
Score = 58.2 bits (139), Expect = 3e-08
Identities = 47/193 (24%), Positives = 80/193 (41%), Gaps = 17/193 (8%)
Query: 244 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN----------NLD 293
V+ S+ ED + + + GQS L C G P I+W ++ ++ +L
Sbjct: 14 VVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLG 73
Query: 294 LEDINDFG--DDG-SLYITKVTTTHVGNYTCYADGYEQVYQT--HIFQVNVPPVIRVYPE 348
+ D+G SL+ ++ G Y+C A+ Q H+ + P V+
Sbjct: 74 WGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAA 133
Query: 349 SQARE-PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYED 407
+ G L+C G+P PQ+ W K+ + P L +Q +G + I+ D
Sbjct: 134 QEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG-GPHLQVQEDGQVLRITGSHVGD 192
Query: 408 TGAYTCIAKNEAG 420
G Y C+A + AG
Sbjct: 193 EGRYQCVAFSPAG 205
Score = 57.8 bits (138), Expect = 4e-08
Identities = 55/215 (25%), Positives = 82/215 (38%), Gaps = 24/215 (11%)
Query: 234 ALEEFYRAFQVIQLSLP------EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNI 287
A+ E + FQ+ L P ED TV L C P I W ++
Sbjct: 1239 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1298
Query: 288 ILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRV 345
+I L I G YTC E V H+ +V +PP I
Sbjct: 1299 PFEAS--RNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHV-EVLIPPSIS- 1354
Query: 346 YPESQAREPGV---------TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 396
+ E GV T +L C + +P P + W K+G +TP S +L + G
Sbjct: 1355 -KDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTP--SSRLQVLGEGR 1411
Query: 397 EVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ I + D+G Y C+A N AG D+ ++ ++
Sbjct: 1412 LLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 1446
Score = 57.8 bits (138), Expect = 4e-08
Identities = 49/165 (29%), Positives = 69/165 (41%), Gaps = 20/165 (12%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G L C +G P + W ++ L + LE SL + V G Y+C
Sbjct: 2139 GSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQ------GPSLQLEAVGAGDSGTYSCV 2192
Query: 323 ADGYEQVYQTHIFQVNV--PPVIRV--YPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 378
A + H FQ+ V PP I P + PG L C A+G P+P + W K+G
Sbjct: 2193 AVSEAGEARRH-FQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDG 2251
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+T L+ N + VR D G YTC+A++ AG E
Sbjct: 2252 QALT-------RLENNSRATRVLRVR--DAGLYTCLAESPAGAIE 2287
Score = 57.8 bits (138), Expect = 4e-08
Identities = 41/161 (25%), Positives = 68/161 (42%), Gaps = 3/161 (1%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
+V Q+A+L C G P + W+++ + L+ + +GSL I V G+Y
Sbjct: 2403 SVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRF--EILPEGSLRIQPVLAQDAGHYL 2460
Query: 321 CYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
C A Q +V PP I P + A L C A G PKP + W K+G
Sbjct: 2461 CLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQ 2520
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ +L + + + ++ +D+ + C+ NE G
Sbjct: 2521 KLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVG 2561
Score = 56.6 bits (135), Expect = 9e-08
Identities = 38/157 (24%), Positives = 68/157 (43%), Gaps = 3/157 (1%)
Query: 268 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGY 326
L+C G P ++W ++ ++ + F L + + G Y+C A
Sbjct: 715 LTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAV 774
Query: 327 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 386
+ Q + QV++PP I + + + +L C + +P P L W K+G + P+
Sbjct: 775 GEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPG 834
Query: 387 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
L+ A+ + + + D G YTC A N+AG E
Sbjct: 835 VHLS--ADKALLQVDRADVWDAGHYTCEALNQAGHSE 869
Score = 55.8 bits (133), Expect = 2e-07
Identities = 47/169 (27%), Positives = 69/169 (40%), Gaps = 11/169 (6%)
Query: 257 ITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGS-LYITKVTTTH 315
+ A G+ L C +G P + W + + + + DGS L +
Sbjct: 323 VVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLET---DGSVLRLESPGEAS 379
Query: 316 VGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPE--SQAREPGVTASLRCHAEGIPKPQ 371
G Y+C A E V Q + +V VPP + V G L C A G P P
Sbjct: 380 SGLYSCVASSPAGEAVLQYSV-EVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPT 438
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ WL+NG Q+ Q G+ +HI +V + +G + C A NEAG
Sbjct: 439 IQWLQNGRPAEELAGVQVASQ--GTTLHIDHVELDHSGLFACQATNEAG 485
Score = 55.1 bits (131), Expect = 3e-07
Identities = 62/244 (25%), Positives = 97/244 (39%), Gaps = 33/244 (13%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTHVGN-- 318
G L C G P + W ++ ++ L+ +DG + ++T +HVG+
Sbjct: 141 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ----VQEDGQ--VLRITGSHVGDEG 194
Query: 319 -YTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVT----ASLRCHAEGIPKPQLG 373
Y C A Q FQ+ V ++ ++ E V L C A G+P P +
Sbjct: 195 RYQCVAFS-PAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNIT 253
Query: 374 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 433
W K+G + S ++ G ++ + + D G YTC A N G E + L V
Sbjct: 254 WFKDGALLPT--STKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV--Y 309
Query: 434 ARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKA 493
T+ EG G G + V G V +EC + H P+ L + E P A
Sbjct: 310 VPPTI-------EGAG-GRPYVVKAVAGRPV--ALECVARGHPSPT---LSWHHEGLPVA 356
Query: 494 EGDE 497
E +E
Sbjct: 357 ESNE 360
Score = 50.8 bits (120), Expect = 5e-06
Identities = 42/173 (24%), Positives = 67/173 (38%), Gaps = 6/173 (3%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 309
P L++TA T A+L C G+ +P ++W ++ L+ + +L +T
Sbjct: 2486 PSPSNLTLTAHT---PALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLT 2542
Query: 310 KVTTTHVGNYTCYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 368
+ C + ++ + V+VPP I L CH+ GIP
Sbjct: 2543 APGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIP 2602
Query: 369 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV 421
P + W K G + + S + E I G YTC A+N AGV
Sbjct: 2603 APTVSWSKAGAQLGARGSGYRVSPSGALE--IGQALPIHAGRYTCSARNSAGV 2653
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/183 (24%), Positives = 73/183 (39%), Gaps = 8/183 (4%)
Query: 252 DQKLSITAATVGQSAVLS--CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYIT 309
D + + TV S+ +S C G P I W +N + + + + G L ++
Sbjct: 1565 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQ--VLQVS 1622
Query: 310 KVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREP-GVTASLRCHAEGI 367
+Y C A+ + +V VPP I Q + SL C
Sbjct: 1623 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAH 1682
Query: 368 PKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISS 427
P P++ W K+ ++ L +++ L + + R D+G YTC A N AG D+ +
Sbjct: 1683 PNPEVTWYKDSQALS--LGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQ 1740
Query: 428 LFV 430
L V
Sbjct: 1741 LSV 1743
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 9/171 (5%)
Query: 255 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 314
L A + S L C + P + W +++ L+ E++ +L + + +
Sbjct: 1662 LEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLG--EEVFLLPGTHTLQLGRARLS 1719
Query: 315 HVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYP----ESQAREPGVTASLRCHAEGIPK 369
G YTC A Q + V VPP R P ++ G A L C + +P+
Sbjct: 1720 DSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPE 1779
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
P + W K+G + L+++ G + I + D G Y+C N AG
Sbjct: 1780 PTVTWYKDGQPLV--LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG 1828
Score = 49.7 bits (117), Expect = 1e-05
Identities = 43/164 (26%), Positives = 66/164 (40%), Gaps = 16/164 (9%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
T G L C QGT +P I W ++ L L ++ S + G YT
Sbjct: 2226 TPGAPMELLCDAQGTPQPNITWHKDGQALTRL---------ENNSRATRVLRVRDAGLYT 2276
Query: 321 CYADG-YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS---LRCHAEGIPKPQLGWLK 376
C A+ + ++ +V PP I V P G+ L C E P P++ W +
Sbjct: 2277 CLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHR 2335
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+GI + Q G + + + D+G Y+C A+N AG
Sbjct: 2336 DGIVLQEDAHTQ--FPERGRFLQLQALSTADSGDYSCTARNAAG 2377
Score = 47.8 bits (112), Expect = 4e-05
Identities = 50/189 (26%), Positives = 76/189 (40%), Gaps = 13/189 (6%)
Query: 240 RAFQVIQLSLPE-----DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDL 294
R F++ L PE D +ITAA + L C G P I W R ++
Sbjct: 1058 RKFELSVLVPPELIGDLDPLTNITAA-LHSPLTLLCEAMGIPPPAIRWFRGEEPVS--PG 1114
Query: 295 EDINDFGDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQARE 353
ED L +T+ G Y+C A + + +V VPP I + +
Sbjct: 1115 EDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIK 1174
Query: 354 --PGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAY 411
G TA L C+ G P+P+L W K+G + + ++ +G + + G Y
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHIS--PDGVLLQVLQANLSSAGHY 1232
Query: 412 TCIAKNEAG 420
+CIA N G
Sbjct: 1233 SCIAANAVG 1241
Score = 47.4 bits (111), Expect = 6e-05
Identities = 43/186 (23%), Positives = 75/186 (40%), Gaps = 16/186 (8%)
Query: 244 VIQLSLP-----EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIN 298
V+Q+ +P E+ +S+ A +S L C P + W ++ L ++
Sbjct: 782 VLQVHMPPSILGEELNVSVVA---NESVALECQSHAMPPPVLSWWKDGRPLE--PRPGVH 836
Query: 299 DFGDDGSLYITKVTTTHVGNYTC----YADGYEQVYQTHIFQVNVPPVIRVYPESQAREP 354
D L + + G+YTC A E+ Y +++ V P +R RE
Sbjct: 837 LSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-LRESHTLTVRE- 894
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
G L C G+P P++ W K+G + + + + A G +++ + G YTC
Sbjct: 895 GHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCE 954
Query: 415 AKNEAG 420
N G
Sbjct: 955 CSNVVG 960
>gi|15826840 PTK7 protein tyrosine kinase 7 isoform a precursor
[Homo sapiens]
Length = 1070
Score = 79.0 bits (193), Expect = 2e-14
Identities = 59/174 (33%), Positives = 87/174 (50%), Gaps = 13/174 (7%)
Query: 264 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD--GSLYITKVTTTHVGNYTC 321
+ A + C+ G +P I W+R D + ++ D G+L+ +VT GNYTC
Sbjct: 518 KEATVPCSATGREKPTIKWER-------ADGSSLPEWVTDNAGTLHFARVTRDDAGNYTC 570
Query: 322 YA-DGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL-KNG 378
A +G + + H+ V V +V PE G TA L+C A+G PKP + W K+
Sbjct: 571 IASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKDR 630
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
I KL ++ + NGS V I +V ED+G YTCIA N + + L+V D
Sbjct: 631 ILDPTKLGPRMHIFQNGSLV-IHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVD 683
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/178 (24%), Positives = 70/178 (39%), Gaps = 25/178 (14%)
Query: 247 LSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSL 306
L P+D +L G+ L C Q T +P ++W RN ++++ + + +G+L
Sbjct: 415 LKKPQDSQLE-----EGKPGYLDCLTQATPKPTVVWYRNQMLISE---DSRFEVFKNGTL 466
Query: 307 YITKVTTTHVGNYTCYA-------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS 359
I V Y C + + +V + PP Q E A+
Sbjct: 467 RINSVEVYDGTWYRCMSSTPAGSIEAQARVQVLEKLKFTPPP-----QPQQCMEFDKEAT 521
Query: 360 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 417
+ C A G KP + W + P+ + N +H + V +D G YTCIA N
Sbjct: 522 VPCSATGREKPTIKWERADGSSLPE-----WVTDNAGTLHFARVTRDDAGNYTCIASN 574
Score = 48.9 bits (115), Expect = 2e-05
Identities = 53/239 (22%), Positives = 96/239 (40%), Gaps = 28/239 (11%)
Query: 260 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-FGDDGSLYITKVTTTH-VG 317
A G+ A+L C ++ + W +L+ ++D F SL V G
Sbjct: 43 ALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG 97
Query: 318 NYTCYA-------DGYEQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPK 369
+ C A + +I + PV+ +P S+A +P +LRCH +G P+
Sbjct: 98 TFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPR 157
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P W ++G ++ S T+ + + + E +G Y+C A + G S F
Sbjct: 158 PTYQWFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFG-QACSSQNF 215
Query: 430 VEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDE 488
A ++ A ++ + + + YE+ + C+F PS + L F+DE
Sbjct: 216 TLSIADESFARVVLAPQDVVVAR-----YEEAM-----FHCQFSAQPPPSLQWL-FEDE 263
Score = 44.7 bits (104), Expect = 4e-04
Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 12/123 (9%)
Query: 303 DGSLYITKVTTTHVGNYTCYADGYEQV-----YQTHIFQVNVPPVIRVYPESQAREPGVT 357
+GSL +T+V + G Y C G H+ ++ P+ + E VT
Sbjct: 283 NGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
Query: 358 ASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 417
+G+P+P + W G+ +L + G E+ ++N+ D G YTC A N
Sbjct: 343 C---LPPKGLPEPSVWWEHAGV----RLPTHGRVYQKGHELVLANIAESDAGVYTCHAAN 395
Query: 418 EAG 420
AG
Sbjct: 396 LAG 398
Score = 39.7 bits (91), Expect = 0.012
Identities = 24/66 (36%), Positives = 30/66 (45%)
Query: 258 TAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVG 317
T G +A+L C QG +P I WK + IL+ L +GSL I V G
Sbjct: 601 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 660
Query: 318 NYTCYA 323
YTC A
Sbjct: 661 RYTCIA 666
Score = 33.9 bits (76), Expect = 0.65
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 13/102 (12%)
Query: 347 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNV-RY 405
P SQ G A LRC E + WL +G + + A GS + + V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 406 EDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEG 447
+D+G + C+A+++ +E S+ NI W E G
Sbjct: 94 QDSGTFQCVARDDVTGEEARSA--------NASFNIKWIEAG 127
>gi|22902126 PTK7 protein tyrosine kinase 7 isoform b precursor
[Homo sapiens]
Length = 1030
Score = 76.6 bits (187), Expect = 9e-14
Identities = 66/235 (28%), Positives = 99/235 (42%), Gaps = 55/235 (23%)
Query: 247 LSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNN--------------- 291
L P+D +L G+ L C Q T +P ++W RN ++++
Sbjct: 415 LKKPQDSQLE-----EGKPGYLDCLTQATPKPTVVWYRNQMLISEDSRFEVFKNGTLRIN 469
Query: 292 -----------------------------LDLEDINDFGDD--GSLYITKVTTTHVGNYT 320
LD + ++ D G+L+ +VT GNYT
Sbjct: 470 SVEVYDGTWYRCMSSTPAGSIEAQARVQVLDGSSLPEWVTDNAGTLHFARVTRDDAGNYT 529
Query: 321 CYA-DGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL-KN 377
C A +G + + H+ V V +V PE G TA L+C A+G PKP + W K+
Sbjct: 530 CIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQCEAQGDPKPLIQWKGKD 589
Query: 378 GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
I KL ++ + NGS V I +V ED+G YTCIA N + + L+V D
Sbjct: 590 RILDPTKLGPRMHIFQNGSLV-IHDVAPEDSGRYTCIAGNSCNIKHTEAPLYVVD 643
Score = 48.9 bits (115), Expect = 2e-05
Identities = 53/239 (22%), Positives = 96/239 (40%), Gaps = 28/239 (11%)
Query: 260 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-FGDDGSLYITKVTTTH-VG 317
A G+ A+L C ++ + W +L+ ++D F SL V G
Sbjct: 43 ALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG 97
Query: 318 NYTCYA-------DGYEQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPK 369
+ C A + +I + PV+ +P S+A +P +LRCH +G P+
Sbjct: 98 TFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPR 157
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P W ++G ++ S T+ + + + E +G Y+C A + G S F
Sbjct: 158 PTYQWFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFG-QACSSQNF 215
Query: 430 VEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDE 488
A ++ A ++ + + + YE+ + C+F PS + L F+DE
Sbjct: 216 TLSIADESFARVVLAPQDVVVAR-----YEEAM-----FHCQFSAQPPPSLQWL-FEDE 263
Score = 44.7 bits (104), Expect = 4e-04
Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 12/123 (9%)
Query: 303 DGSLYITKVTTTHVGNYTCYADGYEQV-----YQTHIFQVNVPPVIRVYPESQAREPGVT 357
+GSL +T+V + G Y C G H+ ++ P+ + E VT
Sbjct: 283 NGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
Query: 358 ASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 417
+G+P+P + W G+ +L + G E+ ++N+ D G YTC A N
Sbjct: 343 C---LPPKGLPEPSVWWEHAGV----RLPTHGRVYQKGHELVLANIAESDAGVYTCHAAN 395
Query: 418 EAG 420
AG
Sbjct: 396 LAG 398
Score = 39.7 bits (91), Expect = 0.012
Identities = 33/131 (25%), Positives = 59/131 (45%), Gaps = 6/131 (4%)
Query: 306 LYITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCH 363
L + + + G YTC+A ++ +I VP ++ +SQ E G L C
Sbjct: 376 LVLANIAESDAGVYTCHAANLAGQRRQDVNITVATVPSWLKKPQDSQLEE-GKPGYLDCL 434
Query: 364 AEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ PKP + W +N + I+ + + NG+ + I++V D Y C++ AG E
Sbjct: 435 TQATPKPTVVWYRNQMLISE--DSRFEVFKNGT-LRINSVEVYDGTWYRCMSSTPAGSIE 491
Query: 424 DISSLFVEDSA 434
+ + V D +
Sbjct: 492 AQARVQVLDGS 502
Score = 33.9 bits (76), Expect = 0.65
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 13/102 (12%)
Query: 347 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNV-RY 405
P SQ G A LRC E + WL +G + + A GS + + V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 406 EDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEG 447
+D+G + C+A+++ +E S+ NI W E G
Sbjct: 94 QDSGTFQCVARDDVTGEEARSA--------NASFNIKWIEAG 127
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 75.9 bits (185), Expect = 1e-13
Identities = 54/179 (30%), Positives = 83/179 (46%), Gaps = 12/179 (6%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDIND------FGDDGSLYITKVTTT 314
G+ + C G+ P I W +I N + +D ++G+LY KV
Sbjct: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
Query: 315 HVGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPKPQ 371
G+YTCYA + + H+ + P IR ++ R + G TA L C G PKP+
Sbjct: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPK 2172
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
+ WL D+ + T ANGS + I+ V+ D+G Y C+A+N +G D + L V
Sbjct: 2173 IFWLLPSNDMISFSIDRYTFHANGS-LTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
Score = 67.8 bits (164), Expect = 4e-11
Identities = 56/187 (29%), Positives = 91/187 (48%), Gaps = 19/187 (10%)
Query: 263 GQSAVLSCAIQGTLRPPIIW--KRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
G +AVL C + G +P I W N++I ++D F +GSL I KV G Y
Sbjct: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYT---FHANGSLTINKVKLLDSGEYV 2212
Query: 321 CYADGYE----QVYQTHIFQVNVPPVIRVYPESQA--REPGVTASLR---CHAEGIPKPQ 371
C A ++Y+ + V+ PP+I ++ + V S + C AEG P P+
Sbjct: 2213 CVARNPSGDDTKMYKLDV--VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPE 2270
Query: 372 LGWLK-NGIDIT-PKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
+ W+ + I +T P ++T+ NG+ + I NVR D+ + C+A+NE G + L
Sbjct: 2271 VMWIMPDNIFLTAPYYGSRITVHKNGT-LEIRNVRLSDSADFICVARNEGGESVLVVQLE 2329
Query: 430 VEDSARK 436
V + R+
Sbjct: 2330 VLEMLRR 2336
Score = 67.4 bits (163), Expect = 5e-11
Identities = 53/168 (31%), Positives = 79/168 (47%), Gaps = 10/168 (5%)
Query: 260 ATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
A +G+S L+C++ G P IIW N +N +GS I+K T G
Sbjct: 2349 AQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGK 2408
Query: 319 YTCYAD---GYEQVYQTHIFQVNVPPVIRVY-PESQAREPGVTASLRCHAEGIPKPQLGW 374
Y C A GY + + I ++ PVI Y P + G + SL C ++GIPKP + W
Sbjct: 2409 YRCAARNKVGY--IEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKW 2466
Query: 375 -LKNGIDI-TPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ +G + P+++ + L NG+ V I D G Y C A+N G
Sbjct: 2467 TMPSGYVVDRPQINGKYILHDNGTLV-IKEATAYDRGNYICKAQNSVG 2513
Score = 63.9 bits (154), Expect = 6e-10
Identities = 53/188 (28%), Positives = 88/188 (46%), Gaps = 25/188 (13%)
Query: 252 DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG------DDGS 305
+Q+ + T G+S L C +GT +P + W ++ + +++ + +G+
Sbjct: 1846 EQRRQVIVGTWGESLKLPCTAKGTPQPSVYW----VLSDGTEVKPLQFTNSKLFLFSNGT 1901
Query: 306 LYITKVTTTHVGNYTCYA---DGYEQ--VYQTHIFQVNVPPVIRVYPESQAREP---GVT 357
LYI + ++ G Y C A G E+ V T +V P R+ SQ R G
Sbjct: 1902 LYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSP---RIEAASQKRTEVNFGDK 1958
Query: 358 ASLRCHAEGIPKPQLGW---LKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
L C A G PKPQ+ W K +D ++ + + NGS + I +V +D+G Y C+
Sbjct: 1959 LLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGS-LFIGSVTEKDSGVYLCV 2017
Query: 415 AKNEAGVD 422
A+N+ G D
Sbjct: 2018 ARNKMGDD 2025
Score = 63.5 bits (153), Expect = 8e-10
Identities = 53/174 (30%), Positives = 72/174 (41%), Gaps = 20/174 (11%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKR-NNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
G+S L C G +P I W + +++ + D+G+L I + T GNY C
Sbjct: 2447 GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYIC 2506
Query: 322 YADGYEQVYQTHIFQVNVPPVIRVYPESQAREP--------GVTASLRCHAEGIPKPQLG 373
A V T I VP +I YP P G L C A G+PKP++
Sbjct: 2507 KAQN--SVGHTLI---TVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEIT 2561
Query: 374 WLKNGIDITPKLSKQLT-----LQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
W + SK+ T L G+ V I N + D+G Y C AKN G D
Sbjct: 2562 WEMPDHSLLSTASKERTHGSEQLHLQGTLV-IQNPQTSDSGIYKCTAKNPLGSD 2614
Score = 57.4 bits (137), Expect = 6e-08
Identities = 52/203 (25%), Positives = 84/203 (41%), Gaps = 18/203 (8%)
Query: 247 LSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSL 306
+S + KL T VG + L+C QG P + W +L + +DG +
Sbjct: 475 ISRDNNTKLEHTVL-VGGTVGLNCPGQGDPTPHVDW-----LLADGSKVRAPYVSEDGRI 528
Query: 307 YITK--------VTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREP---G 355
I K + G Y C + Y+ V P++ Y E+ G
Sbjct: 529 LIDKSGKLELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIG 588
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
T L CH+ GIP + W+ G ++ + S+ + NG+ + I V +D G Y C+A
Sbjct: 589 ETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGT-LRILQVTPKDQGYYRCVA 647
Query: 416 KNEAGVDEDISSLFVEDSARKTL 438
N +GVD I + V+ ++ L
Sbjct: 648 ANPSGVDFLIFQVSVKMKGQRPL 670
Score = 56.2 bits (134), Expect = 1e-07
Identities = 51/187 (27%), Positives = 82/187 (43%), Gaps = 27/187 (14%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGD-------DGSLYITKVTTTH 315
G + L C +G P + W IL N + + G DG+L + ++
Sbjct: 1760 GSTVELKCRAEGRPSPTVTW-----ILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYD 1814
Query: 316 VGNYTCYAD--GYEQVYQTHIFQVNVPPVIRVYPESQAREP-----GVTASLRCHAEGIP 368
G Y C A G + I + PPVI Q R+ G + L C A+G P
Sbjct: 1815 RGFYKCVASNPGGQDSLLVKIQVIAAPPVIL----EQRRQVIVGTWGESLKLPCTAKGTP 1870
Query: 369 KPQLGW-LKNGIDITPK--LSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
+P + W L +G ++ P + +L L +NG+ ++I N+ D G Y CIA + G + +
Sbjct: 1871 QPSVYWVLSDGTEVKPLQFTNSKLFLFSNGT-LYIRNLASSDRGTYECIATSSTGSERRV 1929
Query: 426 SSLFVED 432
L +E+
Sbjct: 1930 VMLTMEE 1936
Score = 54.3 bits (129), Expect = 5e-07
Identities = 47/164 (28%), Positives = 74/164 (45%), Gaps = 9/164 (5%)
Query: 270 CAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA--DGY 326
C +GT P ++W +NI L +G+L I V + ++ C A +G
Sbjct: 2261 CRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGG 2320
Query: 327 EQVY--QTHIFQVNVPPVIR-VYPESQAREPGVTASLRCHAEGIPKPQLGW-LKNGIDIT 382
E V Q + ++ P R + E + G + +L C +G P P++ W L NG +
Sbjct: 2321 ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS 2380
Query: 383 P-KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
S Q + +NGS + IS ED G Y C A+N+ G E +
Sbjct: 2381 NGPQSYQYLIASNGSFI-ISKTTREDAGKYRCAARNKVGYIEKL 2423
Score = 53.9 bits (128), Expect = 6e-07
Identities = 49/171 (28%), Positives = 72/171 (42%), Gaps = 21/171 (12%)
Query: 266 AVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG-----DDGSLYITKVTTTHVGNYT 320
A L C G P I W R + + LDL +G+L I +V G Y
Sbjct: 1666 AFLPCEAVGNPLPTIHWTR---VPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYL 1722
Query: 321 CYADGYEQVYQTHIFQ--VNVPPVIRVYPESQARE----PGVTASLRCHAEGIPKPQLGW 374
C A H+ V+ PP I E + +E G T L+C AEG P P + W
Sbjct: 1723 CSASNLFGTDHLHVTLSVVSYPPRIL---ERRTKEITVHSGSTVELKCRAEGRPSPTVTW 1779
Query: 375 L---KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
+ + + + + S+Q + +G+ V + N+ D G Y C+A N G D
Sbjct: 1780 ILANQTVVSESSQGSRQAVVTVDGTLV-LHNLSIYDRGFYKCVASNPGGQD 1829
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 75.5 bits (184), Expect = 2e-13
Identities = 50/176 (28%), Positives = 81/176 (46%), Gaps = 13/176 (7%)
Query: 258 TAATVGQSAVLSCAIQGTLRPPII--WKRNNIILNNLDLED-INDFGDDGS-------LY 307
T A VG+ +C+ + P+ WK++N +L N D+E+ ++ DG L+
Sbjct: 504 TMAMVGKDIRFTCSAASSSSSPMTFAWKKDNEVLTNADMENFVHVHAQDGEVMEYTTILH 563
Query: 308 ITKVTTTHVGNYTCYADGYEQVYQTHIFQ--VNVPPVIRVYPESQAREPGVTASLRCHAE 365
+ +VT H G Y C + +H + VNV P P A L C A
Sbjct: 564 LRQVTFGHEGRYQCVITNHFGSTYSHKARLTVNVLPSFTKTPHDITIRTTTMARLECAAT 623
Query: 366 GIPKPQLGWLKN-GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
G P PQ+ W K+ G D +++ + + I++V+ +D G Y+C A+N AG
Sbjct: 624 GHPNPQIAWQKDGGTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYSCTAQNSAG 679
Score = 58.2 bits (139), Expect = 3e-08
Identities = 49/175 (28%), Positives = 70/175 (40%), Gaps = 12/175 (6%)
Query: 266 AVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-----FGDDGSLYITKVTTTHVGNYT 320
A L CA G P I W+++ D + DD +IT V G Y+
Sbjct: 616 ARLECAATGHPNPQIAWQKDG----GTDFPAARERRMHVMPDDDVFFITDVKIDDAGVYS 671
Query: 321 CYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
C A + V P + V E + G T +L+C A G P P++ W K
Sbjct: 672 CTAQNSAGSISANATLTVLETPSLVVPLEDRVVSVGETVALQCKATGNPPPRITWFKG-- 729
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSA 434
D L+++ L + + + NV ED G YTC N G + S L V +A
Sbjct: 730 DRPLSLTERHHLTPDNQLLVVQNVVAEDAGRYTCEMSNTLGTERAHSQLSVLPAA 784
Score = 30.0 bits (66), Expect = 9.4
Identities = 22/100 (22%), Positives = 37/100 (37%), Gaps = 9/100 (9%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
+VG++ L C G P I W + + L+ + + D+ L + V G YT
Sbjct: 705 SVGETVALQCKATGNPPPRITWFKGDRPLSLTERHHLTP--DNQLLVVQNVVAEDAGRYT 762
Query: 321 CYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASL 360
C + H + V P + R+ G T +
Sbjct: 763 CEMSNTLGTERAH-------SQLSVLPAAGCRKDGTTVGI 795
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 75.1 bits (183), Expect = 3e-13
Identities = 58/185 (31%), Positives = 84/185 (45%), Gaps = 21/185 (11%)
Query: 258 TAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG--DDGSLYITKVTTTH 315
T T G +A+L C + G +P I WKR N IL + + I F + G L I V
Sbjct: 489 TTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVR-IPRFMLLESGGLQIAPVFIQD 547
Query: 316 VGNYTCYADGYEQVYQTHIFQVNVPPVIRVY--------PESQAREPGVTASLRCHAEGI 367
GNYTCYA E +N + V+ PE G TA+L C A
Sbjct: 548 AGNYTCYAANTEG-------SLNASATLTVWNRTSIVHPPEDHVVIKGTTATLHCGATHD 600
Query: 368 PKPQLG--WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
P+ L W K+ + +TP + ++ ++ +GS + IS D G Y+C +E G D +
Sbjct: 601 PRVSLRYVWKKDNVALTPSSTSRIVVEKDGS-LLISQTWSGDIGDYSCEIVSEGGNDSRM 659
Query: 426 SSLFV 430
+ L V
Sbjct: 660 ARLEV 664
Score = 65.5 bits (158), Expect = 2e-10
Identities = 45/167 (26%), Positives = 73/167 (43%), Gaps = 8/167 (4%)
Query: 259 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
+A V ++ + C G P + W ++ I ++ L G L I K+ G
Sbjct: 397 SAEVEETVDIGCQAMGVPLPTLQWYKDAISISRLQNPRYKVLAS-GGLRIQKLRPEDSGI 455
Query: 319 YTCYADGYEQVYQTHIFQ--VNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 376
+ C+A QTH + N+ PV P G+TA LRC G PKP + W +
Sbjct: 456 FQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITWKR 515
Query: 377 NGIDI---TPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ + ++ + + L++ G + I+ V +D G YTC A N G
Sbjct: 516 ENHILASGSVRIPRFMLLESGG--LQIAPVFIQDAGNYTCYAANTEG 560
Score = 33.9 bits (76), Expect = 0.65
Identities = 48/182 (26%), Positives = 75/182 (41%), Gaps = 32/182 (17%)
Query: 252 DQKLSITAATVGQSAVLSCA-IQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYI 308
DQ+ +++ G++A+L+ I RP + W R + II +N + + L I
Sbjct: 197 DQRKTVSQ---GRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITL-----ENQLVI 248
Query: 309 TKVTTTHVGNYTCYADGYEQ--------VYQTHIFQVNVP----PVIRVYPESQAREPGV 356
TT+ G Y A + ++ + V P P I V P +++ G
Sbjct: 249 LATTTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGS 308
Query: 357 T-ASLRCHAEGIPKPQLG--WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTC 413
+ +L C A P L W +NG+ IT L + G + ISN DTG Y C
Sbjct: 309 SETTLECIASARPVEDLSVTWKRNGVRITSGL------HSFGRRLTISNPTSADTGPYVC 362
Query: 414 IA 415
A
Sbjct: 363 EA 364
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 75.1 bits (183), Expect = 3e-13
Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 14/170 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDIN--DFGDDGSLYITKVTTTHVG 317
G++ C +G +P + W++ N++ N + + G L IT + + G
Sbjct: 344 GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 403
Query: 318 NYTCYAD-------GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKP 370
Y C A Q+ T + PP+I P +Q TA L+C A G P P
Sbjct: 404 YYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP 463
Query: 371 QLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ WLK G P + T+Q G+ + I N+R DTG YTC+A + +G
Sbjct: 464 VISWLKEGFTF-PGRDPRATIQEQGT-LQIKNLRISDTGTYTCVATSSSG 511
Score = 63.5 bits (153), Expect = 8e-10
Identities = 45/157 (28%), Positives = 70/157 (44%), Gaps = 10/157 (6%)
Query: 270 CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADG-YEQ 328
C +QG +P + WK+++ L D DD +L I K +T G Y C A+ +
Sbjct: 262 CQVQGDPQPTVRWKKDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK 317
Query: 329 VYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID--ITPKLS 386
+ + V PP V P Q G T + C +G P+P + W K G + P
Sbjct: 318 MEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQP 377
Query: 387 KQLTLQANGS---EVHISNVRYEDTGAYTCIAKNEAG 420
+Q + + S ++ I+N++ D G Y C A AG
Sbjct: 378 QQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 414
Score = 52.4 bits (124), Expect = 2e-06
Identities = 51/201 (25%), Positives = 82/201 (40%), Gaps = 18/201 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKV-----TTTH 315
G+ L+C +G P I W ++ + + D GSL+ ++ +
Sbjct: 61 GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPD 120
Query: 316 VGNYTCYADGY--EQVYQTHIFQVNV-PPVIRVYPESQAREPGVTASLRCHA-EGIPKPQ 371
G+Y C A Y E V + +V + R P G A L C G P+P
Sbjct: 121 EGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPT 180
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV-DEDISSLFV 430
+ W K+ + I K + + G ++ ISN R D G YTC+ N G D D + L V
Sbjct: 181 IYWKKDKVRIDDKEER---ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV 237
Query: 431 EDS---ARKTLANILWREEGL 448
+ R+ + ++ EE +
Sbjct: 238 FERPTFLRRPINQVVLEEEAV 258
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/171 (25%), Positives = 73/171 (42%), Gaps = 10/171 (5%)
Query: 263 GQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
G+ A+L C +G P I WK++ + +++ + E I+ G G L I+ + G YTC
Sbjct: 163 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKE-ERISIRG--GKLMISNTRKSDAGMYTC 219
Query: 322 YADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
+ ++ V P P +Q RC +G P+P + W K+
Sbjct: 220 VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 279
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
D+ P+ + + + I D G Y CIA+N G E ++L V
Sbjct: 280 DL-PRGRYDI---KDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 326
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/124 (28%), Positives = 52/124 (41%), Gaps = 15/124 (12%)
Query: 304 GSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCH 363
G L +T V H GN Q + + Q + PP I +P G +L C
Sbjct: 18 GLLMMTVVFWGHQGN--------GQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCK 69
Query: 364 AEGIPKPQLGWLKNGIDI-----TPKLSKQLTLQANGSEVHISNVRYE--DTGAYTCIAK 416
AEG P P + W K+G + P+ + L + + I + R D G+Y C+A+
Sbjct: 70 AEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVAR 129
Query: 417 NEAG 420
N G
Sbjct: 130 NYLG 133
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 75.1 bits (183), Expect = 3e-13
Identities = 49/170 (28%), Positives = 76/170 (44%), Gaps = 14/170 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDIN--DFGDDGSLYITKVTTTHVG 317
G++ C +G +P + W++ N++ N + + G L IT + + G
Sbjct: 328 GRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 387
Query: 318 NYTCYAD-------GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKP 370
Y C A Q+ T + PP+I P +Q TA L+C A G P P
Sbjct: 388 YYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP 447
Query: 371 QLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ WLK G P + T+Q G+ + I N+R DTG YTC+A + +G
Sbjct: 448 VISWLKEGFTF-PGRDPRATIQEQGT-LQIKNLRISDTGTYTCVATSSSG 495
Score = 63.5 bits (153), Expect = 8e-10
Identities = 45/157 (28%), Positives = 70/157 (44%), Gaps = 10/157 (6%)
Query: 270 CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADG-YEQ 328
C +QG +P + WK+++ L D DD +L I K +T G Y C A+ +
Sbjct: 246 CQVQGDPQPTVRWKKDDADLPR----GRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGK 301
Query: 329 VYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID--ITPKLS 386
+ + V PP V P Q G T + C +G P+P + W K G + P
Sbjct: 302 MEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQP 361
Query: 387 KQLTLQANGS---EVHISNVRYEDTGAYTCIAKNEAG 420
+Q + + S ++ I+N++ D G Y C A AG
Sbjct: 362 QQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAG 398
Score = 52.4 bits (124), Expect = 2e-06
Identities = 51/201 (25%), Positives = 82/201 (40%), Gaps = 18/201 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKV-----TTTH 315
G+ L+C +G P I W ++ + + D GSL+ ++ +
Sbjct: 45 GEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPD 104
Query: 316 VGNYTCYADGY--EQVYQTHIFQVNV-PPVIRVYPESQAREPGVTASLRCHA-EGIPKPQ 371
G+Y C A Y E V + +V + R P G A L C G P+P
Sbjct: 105 EGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPT 164
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGV-DEDISSLFV 430
+ W K+ + I K + + G ++ ISN R D G YTC+ N G D D + L V
Sbjct: 165 IYWKKDKVRIDDKEER---ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTV 221
Query: 431 EDS---ARKTLANILWREEGL 448
+ R+ + ++ EE +
Sbjct: 222 FERPTFLRRPINQVVLEEEAV 242
Score = 50.4 bits (119), Expect = 7e-06
Identities = 44/171 (25%), Positives = 73/171 (42%), Gaps = 10/171 (5%)
Query: 263 GQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
G+ A+L C +G P I WK++ + +++ + E I+ G G L I+ + G YTC
Sbjct: 147 GEPAILECQPPRGHPEPTIYWKKDKVRIDDKE-ERISIRG--GKLMISNTRKSDAGMYTC 203
Query: 322 YADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
+ ++ V P P +Q RC +G P+P + W K+
Sbjct: 204 VGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDA 263
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
D+ P+ + + + I D G Y CIA+N G E ++L V
Sbjct: 264 DL-PRGRYDI---KDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTV 310
Score = 43.1 bits (100), Expect = 0.001
Identities = 29/102 (28%), Positives = 46/102 (45%), Gaps = 7/102 (6%)
Query: 326 YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI---- 381
Y +V + + Q + PP I +P G +L C AEG P P + W K+G +
Sbjct: 16 YVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDK 75
Query: 382 -TPKLSKQLTLQANGSEVHISNVRYE--DTGAYTCIAKNEAG 420
P+ + L + + I + R D G+Y C+A+N G
Sbjct: 76 DDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLG 117
>gi|83281200 protogenin [Homo sapiens]
Length = 1150
Score = 74.3 bits (181), Expect = 4e-13
Identities = 54/166 (32%), Positives = 74/166 (44%), Gaps = 22/166 (13%)
Query: 264 QSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGD----DGSLYITKVTTTHVGNY 319
Q+ VL C G +P I W R LD + I+ F +G+L I+ V H G Y
Sbjct: 250 QTVVLECMATGNPKPIISWSR-------LDHKSIDVFNTRVLGNGNLMISDVRLQHAGVY 302
Query: 320 TCYAD-----GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 374
C A + T V PP +PES R TA C AEGIP P++ W
Sbjct: 303 VCRATTPGTRNFTVAMAT--LTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSW 360
Query: 375 LKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
LKNG K+ ++ S++ I+ + ED Y C+A+N G
Sbjct: 361 LKNG----RKIHSNGRIKMYNSKLVINQIIPEDDAIYQCMAENSQG 402
Score = 40.4 bits (93), Expect = 0.007
Identities = 63/245 (25%), Positives = 95/245 (38%), Gaps = 35/245 (14%)
Query: 185 KYFDADSNGLVDINELTQVIKQEELGKDLFDCTLYVLLKYDDFNADK-HLALEEFYRAFQ 243
K + SNG + I+E+ + + E+ + + C + KY + K HLAL AF+
Sbjct: 83 KRIEVLSNGSLYISEV-EGRRGEQSDEGFYQCL--AMNKYGAILSQKAHLALSTI-SAFE 138
Query: 244 VIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDD 303
V +S T G A +C I I W+ N L + ++ I
Sbjct: 139 VQPIS---------TEVHEGGVARFACKISSHPPAVITWEFNRTTLP-MTMDRITAL-PT 187
Query: 304 GSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNV----------PPVIRVYPESQARE 353
G L I V+ GNY C A ++ + V P I P++
Sbjct: 188 GVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTVIPAKESKSFHTPTIIAGPQNITTS 247
Query: 354 PGVTASLRCHAEGIPKPQLGWLK---NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGA 410
T L C A G PKP + W + ID+ + NG+ + IS+VR + G
Sbjct: 248 LHQTVVLECMATGNPKPIISWSRLDHKSIDVF-----NTRVLGNGN-LMISDVRLQHAGV 301
Query: 411 YTCIA 415
Y C A
Sbjct: 302 YVCRA 306
Score = 35.4 bits (80), Expect = 0.22
Identities = 44/177 (24%), Positives = 70/177 (39%), Gaps = 17/177 (9%)
Query: 251 EDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN-NLDLEDINDFGDDGSLYIT 309
E Q +++T VL C G + + W +N ++ N +E +++ GSLYI+
Sbjct: 44 EPQDVTVTRK---DPVVLDCQAHGEVPIKVTWLKNGAKMSENKRIEVLSN----GSLYIS 96
Query: 310 KVT-----TTHVGNYTCYA-DGYEQVY-QTHIFQVNVPPVIRVYPESQAREPGVTASLRC 362
+V + G Y C A + Y + Q ++ V P S G A C
Sbjct: 97 EVEGRRGEQSDEGFYQCLAMNKYGAILSQKAHLALSTISAFEVQPISTEVHEGGVARFAC 156
Query: 363 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 419
P + W N + P ++T G + I +V D+G Y CIA A
Sbjct: 157 KISSHPPAVITWEFNRTTL-PMTMDRITALPTGV-LQIYDVSQRDSGNYRCIAATVA 211
Score = 35.4 bits (80), Expect = 0.22
Identities = 23/66 (34%), Positives = 36/66 (54%), Gaps = 8/66 (12%)
Query: 360 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNV-----RYEDTGAYTCI 414
L C A G ++ WLKNG ++ +K++ + +NGS ++IS V D G Y C+
Sbjct: 58 LDCQAHGEVPIKVTWLKNGAKMSE--NKRIEVLSNGS-LYISEVEGRRGEQSDEGFYQCL 114
Query: 415 AKNEAG 420
A N+ G
Sbjct: 115 AMNKYG 120
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 73.9 bits (180), Expect = 6e-13
Identities = 52/185 (28%), Positives = 81/185 (43%), Gaps = 6/185 (3%)
Query: 258 TAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVG 317
T VG+S L C+ G P I W R + L ++ + G LYI V G
Sbjct: 351 TEVLVGESVTLECSATGHPPPRISWTRGD--RTPLPVDPRVNITPSGGLYIQNVVQGDSG 408
Query: 318 NYTCYA-DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLK 376
Y C A + + V+ T V P V P+ + G T +C A+G P P + W K
Sbjct: 409 EYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTK 468
Query: 377 NGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARK 436
G ++ + ++ + ++G+ + IS V D G Y C A N G + ++ L V+
Sbjct: 469 GGSQLS--VDRRHLVLSSGT-LRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTP 525
Query: 437 TLANI 441
A+I
Sbjct: 526 VFASI 530
Score = 66.2 bits (160), Expect = 1e-10
Identities = 48/165 (29%), Positives = 73/165 (44%), Gaps = 14/165 (8%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG--DDGSLYITKVTTTHVGN 318
T G + +C +G +P IIW RNN N L ++ + DDG+L I T G
Sbjct: 258 TSGNTVYFTCRAEGNPKPEIIWLRNN---NELSMKTDSRLNLLDDGTLMIQNTQETDQGI 314
Query: 319 YTCYADGYEQVYQT-----HIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLG 373
Y C A +T F P + P++ G + +L C A G P P++
Sbjct: 315 YQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRIS 374
Query: 374 WLKNGIDITP-KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 417
W + D TP + ++ + +G ++I NV D+G Y C A N
Sbjct: 375 WTRG--DRTPLPVDPRVNITPSGG-LYIQNVVQGDSGEYACSATN 416
Score = 63.2 bits (152), Expect = 1e-09
Identities = 45/161 (27%), Positives = 70/161 (43%), Gaps = 9/161 (5%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
GQ+ C +G P I W + + L ++ + G+L I+ V G Y C
Sbjct: 447 GQTVDFQCEAKGNPPPVIAWTKGG---SQLSVDRRHLVLSSGTLRISGVALHDQGQYECQ 503
Query: 323 AD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
A G ++V Q V PV P E G L C ++G P+P + W K+G+
Sbjct: 504 AVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGV 563
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+T S + + G + I++V D G Y C+A+N G
Sbjct: 564 QVTE--SGKFHISPEGF-LTINDVGPADAGRYECVARNTIG 601
Score = 55.8 bits (133), Expect = 2e-07
Identities = 30/80 (37%), Positives = 43/80 (53%), Gaps = 1/80 (1%)
Query: 341 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHI 400
P I P+ G T C AEG PKP++ WL+N +++ K +L L +G+ + I
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGT-LMI 304
Query: 401 SNVRYEDTGAYTCIAKNEAG 420
N + D G Y C+AKN AG
Sbjct: 305 QNTQETDQGIYQCMAKNVAG 324
Score = 36.2 bits (82), Expect = 0.13
Identities = 28/98 (28%), Positives = 40/98 (40%), Gaps = 9/98 (9%)
Query: 248 SLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY 307
S+P D T VG + L C+ QG P I W ++ + + I+ +G L
Sbjct: 529 SIPSD-----TTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHIS---PEGFLT 580
Query: 308 ITKVTTTHVGNYTCYA-DGYEQVYQTHIFQVNVPPVIR 344
I V G Y C A + + + VNVP V R
Sbjct: 581 INDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSR 618
>gi|22902128 PTK7 protein tyrosine kinase 7 isoform c precursor
[Homo sapiens]
Length = 940
Score = 72.8 bits (177), Expect = 1e-12
Identities = 50/132 (37%), Positives = 70/132 (53%), Gaps = 4/132 (3%)
Query: 304 GSLYITKVTTTHVGNYTCYA-DGYEQVYQTHI-FQVNVPPVIRVYPESQAREPGVTASLR 361
G+L+ +VT GNYTC A +G + + H+ V V +V PE G TA L+
Sbjct: 423 GTLHFARVTRDDAGNYTCIASNGPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLQ 482
Query: 362 CHAEGIPKPQLGWL-KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
C A+G PKP + W K+ I KL ++ + NGS V I +V ED+G YTCIA N
Sbjct: 483 CEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLV-IHDVAPEDSGRYTCIAGNSCN 541
Query: 421 VDEDISSLFVED 432
+ + L+V D
Sbjct: 542 IKHTEAPLYVVD 553
Score = 48.9 bits (115), Expect = 2e-05
Identities = 53/239 (22%), Positives = 96/239 (40%), Gaps = 28/239 (11%)
Query: 260 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-FGDDGSLYITKVTTTH-VG 317
A G+ A+L C ++ + W +L+ ++D F SL V G
Sbjct: 43 ALQGRRALLRCEVEAPGPVHVYW-----LLDGAPVQDTERRFAQGSSLSFAAVDRLQDSG 97
Query: 318 NYTCYA-------DGYEQVYQTHIFQVNVPPVIRVYPESQAR-EPGVTASLRCHAEGIPK 369
+ C A + +I + PV+ +P S+A +P +LRCH +G P+
Sbjct: 98 TFQCVARDDVTGEEARSANASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPR 157
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P W ++G ++ S T+ + + + E +G Y+C A + G S F
Sbjct: 158 PTYQWFRDGTPLSDGQSNH-TVSSKERNLTLRPAGPEHSGLYSCCAHSAFG-QACSSQNF 215
Query: 430 VEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDE 488
A ++ A ++ + + + YE+ + C+F PS + L F+DE
Sbjct: 216 TLSIADESFARVVLAPQDVVVAR-----YEEAM-----FHCQFSAQPPPSLQWL-FEDE 263
Score = 44.7 bits (104), Expect = 4e-04
Identities = 32/123 (26%), Positives = 52/123 (42%), Gaps = 12/123 (9%)
Query: 303 DGSLYITKVTTTHVGNYTCYADGYEQV-----YQTHIFQVNVPPVIRVYPESQAREPGVT 357
+GSL +T+V + G Y C G H+ ++ P+ + E VT
Sbjct: 283 NGSLLLTQVRPRNAGIYRCIGQGQRGPPIILEATLHLAEIEDMPLFEPRVFTAGSEERVT 342
Query: 358 ASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 417
+G+P+P + W G+ +L + G E+ ++N+ D G YTC A N
Sbjct: 343 C---LPPKGLPEPSVWWEHAGV----RLPTHGRVYQKGHELVLANIAESDAGVYTCHAAN 395
Query: 418 EAG 420
AG
Sbjct: 396 LAG 398
Score = 39.7 bits (91), Expect = 0.012
Identities = 24/66 (36%), Positives = 30/66 (45%)
Query: 258 TAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVG 317
T G +A+L C QG +P I WK + IL+ L +GSL I V G
Sbjct: 471 TTVYQGHTALLQCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSG 530
Query: 318 NYTCYA 323
YTC A
Sbjct: 531 RYTCIA 536
Score = 33.9 bits (76), Expect = 0.65
Identities = 28/102 (27%), Positives = 43/102 (42%), Gaps = 13/102 (12%)
Query: 347 PESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNV-RY 405
P SQ G A LRC E + WL +G + + A GS + + V R
Sbjct: 38 PSSQDALQGRRALLRCEVEAPGPVHVYWLLDGAPVQDTERR----FAQGSSLSFAAVDRL 93
Query: 406 EDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEG 447
+D+G + C+A+++ +E S+ NI W E G
Sbjct: 94 QDSGTFQCVARDDVTGEEARSA--------NASFNIKWIEAG 127
Score = 30.4 bits (67), Expect = 7.2
Identities = 18/58 (31%), Positives = 26/58 (44%), Gaps = 6/58 (10%)
Query: 362 CHAEGIPKPQLGWLKNGIDITPKLSKQLT--LQANGSEVHISNVRYEDTGAYTCIAKN 417
CHA + G + ++IT L + N +H + V +D G YTCIA N
Sbjct: 391 CHAANLA----GQRRQDVNITVANGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASN 444
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 71.6 bits (174), Expect = 3e-12
Identities = 54/183 (29%), Positives = 77/183 (42%), Gaps = 6/183 (3%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
Q+ S A G+ AVL C + G P W R ++ L + + G +L I+ VT
Sbjct: 244 QRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQ-LRSKKYSLLGGS-NLLISNVT 301
Query: 313 TTHVGNYTCYAD-GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 371
G YTC E + + V VPP +P + + C G P P
Sbjct: 302 DDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPT 361
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ W+KNG + P Q+ GS + I V D G Y C+A+NEAG + + L V
Sbjct: 362 VNWMKNGDVVIPSDYFQIV---GGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVP 418
Query: 432 DSA 434
A
Sbjct: 419 KPA 421
Score = 53.9 bits (128), Expect = 6e-07
Identities = 61/213 (28%), Positives = 91/213 (42%), Gaps = 21/213 (9%)
Query: 219 YVLLKYDDFNADKHLALEEFY-RAFQVIQ-LSLPEDQKLSITAATV-GQSAVLSCAIQGT 275
+VL F+A HL + F +AF ++ LS P D A T+ G + +L C+ +
Sbjct: 15 FVLFGASLFSA--HLQVTGFQIKAFTALRFLSEPSD------AVTMRGGNVLLDCSAESD 66
Query: 276 LRPPII-WKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH-----VGNYTCYA---DGY 326
P+I WK++ I L L +++ +GSL I + + G Y C A D
Sbjct: 67 RGVPVIKWKKDGIHLA-LGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQCEASLGDSG 125
Query: 327 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 386
+ +T V P ES G T L+C G P P + W KN D+TP
Sbjct: 126 SIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPG 185
Query: 387 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 419
+ + IS ++ D G Y C A+N A
Sbjct: 186 DSRVVVLPSGALQISRLQPGDIGIYRCSARNPA 218
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 71.2 bits (173), Expect = 4e-12
Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 259 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 319 YTCYAD---GYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 374
YTC A+ G + T QV + PP V P Q G T + +C A G P+P + W
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 375 LKNGID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 RREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 304
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 321 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 305 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 355
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 433
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 416 KNEAG 420
+G
Sbjct: 492 STPSG 496
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 10/182 (5%)
Query: 253 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 312 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 430 VE 431
V+
Sbjct: 308 VQ 309
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 315
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 316 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 371
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 390
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 391 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 420
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 71.2 bits (173), Expect = 4e-12
Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 259 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 319 YTCYAD---GYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 374
YTC A+ G + T QV + PP V P Q G T + +C A G P+P + W
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 375 LKNGID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 RREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 304
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 321 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 305 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 355
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 433
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 416 KNEAG 420
+G
Sbjct: 492 STPSG 496
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 10/182 (5%)
Query: 253 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 312 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 430 VE 431
V+
Sbjct: 308 VQ 309
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 315
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 316 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 371
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 390
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 391 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 420
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 71.2 bits (173), Expect = 4e-12
Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 259 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 319 YTCYAD---GYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 374
YTC A+ G + T QV + PP V P Q G T + +C A G P+P + W
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 375 LKNGID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 RREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 304
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 321 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 305 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 355
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 433
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 416 KNEAG 420
+G
Sbjct: 492 STPSG 496
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 10/182 (5%)
Query: 253 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 312 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 430 VE 431
V+
Sbjct: 308 VQ 309
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 315
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 316 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 371
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 390
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 391 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 420
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 71.2 bits (173), Expect = 4e-12
Identities = 54/172 (31%), Positives = 79/172 (45%), Gaps = 15/172 (8%)
Query: 259 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 319 YTCYAD---GYEQVYQTHIFQV-NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGW 374
YTC A+ G + T QV + PP V P Q G T + +C A G P+P + W
Sbjct: 289 YTCVAENMVGKAEASATLTVQVGSEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFW 348
Query: 375 LKNGID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 RREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 399
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 304
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 321 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 375
Query: 305 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 355
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 376 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 433
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 434 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 491
Query: 416 KNEAG 420
+G
Sbjct: 492 STPSG 496
Score = 58.5 bits (140), Expect = 2e-08
Identities = 51/182 (28%), Positives = 81/182 (44%), Gaps = 10/182 (5%)
Query: 253 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 312 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 430 VE 431
V+
Sbjct: 308 VQ 309
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 315
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 316 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 371
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 390
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 391 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 420
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|19882241 immunoglobulin superfamily, DCC subclass, member 4
[Homo sapiens]
Length = 1250
Score = 71.2 bits (173), Expect = 4e-12
Identities = 55/194 (28%), Positives = 87/194 (44%), Gaps = 14/194 (7%)
Query: 240 RAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND 299
R V+ ++ PE+ T GQS V+ C P + W R + + D+ +
Sbjct: 240 RGQDVVIVAAPEN-----TTVVSGQSVVMECVASADPTPFVSWVRQDGKPISTDVIVLGR 294
Query: 300 FGDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNV--PPVIRVYPESQAREPGV 356
+L I H G Y C A+ + + T ++ V P I PE+ +R
Sbjct: 295 T----NLLIANAQPWHSGVYVCRANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRAS 350
Query: 357 TASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAK 416
TA C A G P+P L WL NG + P + ++ +Q G + I+ + +D G Y C+A+
Sbjct: 351 TARFVCRASGEPRPALRWLHNGAPLRP--NGRVKVQGGGGSLVITQIGLQDAGYYQCVAE 408
Query: 417 NEAGVDEDISSLFV 430
N AG+ +SL V
Sbjct: 409 NSAGMACAAASLAV 422
Score = 60.1 bits (144), Expect = 8e-09
Identities = 49/174 (28%), Positives = 79/174 (45%), Gaps = 24/174 (13%)
Query: 264 QSAVLSCAIQGTLRPP---IIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH----- 315
Q+AVL+C++ P + W ++ + L D +GSL++++ +
Sbjct: 51 QAAVLNCSLGAAAAGPPTRVTWSKDG---DTLLEHDHLHLLPNGSLWLSQPLAPNGSDES 107
Query: 316 --------VGNYTCYADGYEQVY--QTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE 365
GNY+C A G V QT + ++ ++PESQ E TA CH E
Sbjct: 108 VPEAVGVIEGNYSCLAHGPLGVLASQTAVVKLATLADFSLHPESQTVEENGTARFECHIE 167
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 419
G+P P + W K+ +T +L + NG + I +V+ D G Y C+A N A
Sbjct: 168 GLPAPIITWEKD--QVTLPEEPRLIVLPNG-VLQILDVQESDAGPYRCVATNSA 218
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 70.5 bits (171), Expect = 6e-12
Identities = 51/169 (30%), Positives = 76/169 (44%), Gaps = 12/169 (7%)
Query: 259 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 288
Query: 319 YTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKN 377
YTC A+ + + V PP V P Q G T + +C A G P+P + W +
Sbjct: 289 YTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 348
Query: 378 GID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 349 GSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 396
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 304
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 318 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 305 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 355
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 430
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 431 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 488
Query: 416 KNEAG 420
+G
Sbjct: 489 STPSG 493
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 10/183 (5%)
Query: 253 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 135 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 191
Query: 312 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 251
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 252 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 430 VED 432
V++
Sbjct: 308 VQE 310
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 315
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 43 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 102
Query: 316 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 371
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 162
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 163 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 211
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/92 (30%), Positives = 40/92 (43%), Gaps = 7/92 (7%)
Query: 336 QVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLT 390
Q + PP I +P G A+L C AEG P P + W K G + P+ + L
Sbjct: 24 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 83
Query: 391 LQANGSEVHISNVRYE--DTGAYTCIAKNEAG 420
+ + I + R D G Y C+A+N G
Sbjct: 84 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 70.5 bits (171), Expect = 6e-12
Identities = 51/169 (30%), Positives = 76/169 (44%), Gaps = 12/169 (7%)
Query: 259 AATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGN 318
A TV SA C +G P + W++++ L E DD +L I KVT +G+
Sbjct: 272 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHTLKIRKVTAGDMGS 327
Query: 319 YTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKN 377
YTC A+ + + V PP V P Q G T + +C A G P+P + W +
Sbjct: 328 YTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 387
Query: 378 GID------ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
G P+ S + ++ G ++ I+NV+ D G Y C N AG
Sbjct: 388 GSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVGYYICQTLNVAG 435
Score = 66.6 bits (161), Expect = 9e-11
Identities = 53/185 (28%), Positives = 79/185 (42%), Gaps = 23/185 (12%)
Query: 250 PEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN---NIILNNLDLEDINDFG--DDG 304
P DQ +++ G++ C G +P I W+R N++ + + + F G
Sbjct: 357 PRDQVVAL-----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 305 SLYITKVTTTHVGNYTCYA---------DGYEQVYQTHIFQVNVPPVIRVYPESQAREPG 355
L IT V + VG Y C Y +V T + PPVIR P +Q
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV--TDVIADRPPPVIRQGPVNQTVAVD 469
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
T L C A G P P + W K+G+ ++ + S+ Q + I + DTG YTCIA
Sbjct: 470 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENGVLQIRYAKLGDTGRYTCIA 527
Query: 416 KNEAG 420
+G
Sbjct: 528 STPSG 532
Score = 59.3 bits (142), Expect = 1e-08
Identities = 51/183 (27%), Positives = 82/183 (44%), Gaps = 10/183 (5%)
Query: 253 QKLSITAATVGQSAVLSCAI-QGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
Q S VG+ AV+ C +G P I WK++ L++ D E I G G L IT
Sbjct: 174 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD-ERITIRG--GKLMITYT 230
Query: 312 TTTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ G Y C ++ + ++ V P P + A +A +C A G P
Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 290
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
P + W K+ ++ PK ++ + + I V D G+YTC+A+N G E ++L
Sbjct: 291 PTVRWRKDDGEL-PKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 346
Query: 430 VED 432
V++
Sbjct: 347 VQE 349
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/172 (24%), Positives = 65/172 (37%), Gaps = 14/172 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKR--NNIILNNLDLEDINDFGDDGSLYITKV-----TTTH 315
G+ A L+C +G P I W + + + D GSL+ ++ +
Sbjct: 82 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 141
Query: 316 VGNYTCYADGYEQVYQTHIFQVNVPPV---IRVYPESQAREPGVTASLRCH-AEGIPKPQ 371
G Y C A Y +H + V + R P G A + C G P+P
Sbjct: 142 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 201
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE 423
+ W K+G +P K + G ++ I+ R D G Y C+ N G E
Sbjct: 202 ISWKKDG---SPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 250
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/145 (26%), Positives = 58/145 (40%), Gaps = 19/145 (13%)
Query: 285 NNIILNNL--DLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPV 342
N++ L L D ED+ D G+ T + YT + + Q + PP
Sbjct: 20 NHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYT----------GSRLRQEDFPPR 69
Query: 343 IRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI-----TPKLSKQLTLQANGSE 397
I +P G A+L C AEG P P + W K G + P+ + L +
Sbjct: 70 IVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFF 129
Query: 398 VHISNVRYE--DTGAYTCIAKNEAG 420
+ I + R D G Y C+A+N G
Sbjct: 130 LRIVHGRKSRPDEGVYVCVARNYLG 154
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 70.5 bits (171), Expect = 6e-12
Identities = 72/296 (24%), Positives = 123/296 (41%), Gaps = 37/296 (12%)
Query: 159 KYIMQENENPNGDDISRKKLLVDQMFKYFDADSNGLVDINE--LTQVIKQEEL---GKDL 213
K I+Q N+ + I++K + + ++ D ++N ++ I E +Q +E + L
Sbjct: 390 KLILQGNQIKS---ITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLL 446
Query: 214 FDCTLYVLLKYDDFNADKH-----LALEEFYRAFQVIQLSLPE---DQKLS--------I 257
DC L LL++ N +H A E+ ++ + L + D L
Sbjct: 447 CDCHLKWLLQWLVDNNFQHSVNVSCAHPEWLAGQSILNVDLKDFVCDDFLKPQIRTHPET 506
Query: 258 TAATVGQSAVLSCAIQGTLRPPI--IWKRNNIILNNLDLEDINDFGDDGS--------LY 307
A G + L+C + P+ +W++++ IL ++D E+ + L+
Sbjct: 507 IIALRGMNVTLTCTAVSSSDSPMSTVWRKDSEILYDVDTENFVRYWQQAGEALEYTSILH 566
Query: 308 ITKVTTTHVGNYTCYADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE 365
+ V T G Y C + Q VN P P G A L C AE
Sbjct: 567 LFNVNFTDEGKYQCIVTNHFGSNYSQKAKLTVNEMPSFLKTPMDLTIRTGAMARLECAAE 626
Query: 366 GIPKPQLGWLKN-GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
G P PQ+ W K+ G D +++ + I+NV+ ED G Y+C+A+N AG
Sbjct: 627 GHPAPQISWQKDGGTDFPAARERRMHVMPEDDVFFIANVKIEDMGIYSCMAQNTAG 682
Score = 51.2 bits (121), Expect = 4e-06
Identities = 45/167 (26%), Positives = 68/167 (40%), Gaps = 14/167 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND-----FGDDGSLYITKVTTTHVG 317
G A L CA +G P I W+++ D + +D +I V +G
Sbjct: 616 GAMARLECAAEGHPAPQISWQKDG----GTDFPAARERRMHVMPEDDVFFIANVKIEDMG 671
Query: 318 NYTCYADGYEQVYQTH--IFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL 375
Y+C A + + + P IR E + G TA L+C A G P P+L W
Sbjct: 672 IYSCMAQNTAGGLSANASLTVLETPSFIRPL-EDKTVTRGETAVLQCIAGGSPAPRLNWT 730
Query: 376 KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
K+ D ++++ A + I + ED G YTCI N G +
Sbjct: 731 KD--DGPLLVTERHFFAAANQLLIIVDAGLEDAGKYTCIMSNTLGTE 775
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 70.1 bits (170), Expect = 8e-12
Identities = 48/190 (25%), Positives = 83/190 (43%), Gaps = 10/190 (5%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILN---NLDLEDINDFGDDGSLYIT 309
+KL T+G C I G+ + W ++ ++L NL +++ +L I
Sbjct: 7120 RKLKDVHETLGFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVA---TLQIL 7176
Query: 310 KVTTTHVGNYTCYADG----YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE 365
+ +H+G Y C A + + + VPP + P S G + + +CH
Sbjct: 7177 QTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVT 7236
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
G ++ W K+ +I P + ++TL N + + + V D G YTC A N AG D
Sbjct: 7237 GTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCS 7296
Query: 426 SSLFVEDSAR 435
+ L V++ R
Sbjct: 7297 AQLGVQEPPR 7306
Score = 67.0 bits (162), Expect = 7e-11
Identities = 75/333 (22%), Positives = 131/333 (39%), Gaps = 45/333 (13%)
Query: 252 DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
D +L+ A VG+SA C + GT + W +++ + + I+ + L + KV
Sbjct: 8156 DIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKV 8215
Query: 312 TTTHVGNYTCYADGY----EQVYQTHIFQVNVPPVI-RVYPESQAREPGVTASLRCHAEG 366
G YTCYA Q +I + +PP + E+ G + L G
Sbjct: 8216 DKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAG 8275
Query: 367 IPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDIS 426
+ W KN I+I P + ++T + N + + D G YTC N+AG S
Sbjct: 8276 SQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTS 8335
Query: 427 SLFVEDSARKTLANILWREEGLGIGNMFYVFYEDGIKVIQPIECEF---QRHIKPSEK-- 481
S+ +++ + + + + G YV ++ +PI ++ R IKPS++
Sbjct: 8336 SIVIKEPKKPPVFDQHLTPVTVSEGE--YVQLSCHVQGSEPIRIQWLKAGREIKPSDRCS 8393
Query: 482 --------LLGFQDEVCPKAEGDEVQRC-------VWASAVNVKDK-------------- 512
+L +D V GD V + S V +KDK
Sbjct: 8394 FSFASGTAVLELRD-VAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDG 8452
Query: 513 -FIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVP 544
+V++P + +V+ + + V DP+P
Sbjct: 8453 RLFFVSEP--QSIRVVEKTTATFIAKVGGDPIP 8483
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/197 (23%), Positives = 83/197 (42%), Gaps = 6/197 (3%)
Query: 242 FQVIQLSLPED--QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDIND 299
F++ + LP ++L TVG L+C + G+ + W R+ ++L + + +
Sbjct: 6166 FRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSF 6225
Query: 300 FGDDGSLYITKVTTTHVGNYTCYADG----YEQVYQTHIFQVNVPPVIRVYPESQAREPG 355
+ +L I + +H G Y+C A + + P + P S G
Sbjct: 6226 VDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKSPFFDIKPVSIDVIAG 6285
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
+A CH G ++ W K+ +I P + +T N + I V D+G YTC A
Sbjct: 6286 ESADFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQA 6345
Query: 416 KNEAGVDEDISSLFVED 432
N+ G D + L V++
Sbjct: 6346 TNDVGKDMCSAQLSVKE 6362
Score = 64.7 bits (156), Expect = 3e-10
Identities = 48/183 (26%), Positives = 75/183 (40%), Gaps = 6/183 (3%)
Query: 246 QLSLPEDQKL-----SITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 300
QLS+ E K + A G+S L C I G+ + W RN+ L+ +++
Sbjct: 6357 QLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFI 6416
Query: 301 GDDGSLYITKVTTTHVGNYTCYA-DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTAS 359
L I + + G+Y C A +G + V PPV P G
Sbjct: 6417 NSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKPSPVGALKGSDVI 6476
Query: 360 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 419
L+C G P ++ W+K+ + ++T + + +HI N+ D G Y C A NE
Sbjct: 6477 LQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEV 6536
Query: 420 GVD 422
G D
Sbjct: 6537 GSD 6539
Score = 64.3 bits (155), Expect = 5e-10
Identities = 51/184 (27%), Positives = 80/184 (43%), Gaps = 6/184 (3%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKV 311
+KLS + VG+ L I+G ++W K I+ D I+ + +L ++V
Sbjct: 7496 KKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRV 7555
Query: 312 TTTHVGNYTCYAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 368
+ G YTC G ++ + T V P I PES G T +L C G P
Sbjct: 7556 EPANAGKYTCQIKNDAGMQECFAT--LSVLEPATIVEKPESIKVTTGDTCTLECTVAGTP 7613
Query: 369 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSL 428
+ W K+G ++T +++ S + I NV D+G Y+ +N G D +SL
Sbjct: 7614 ELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASL 7673
Query: 429 FVED 432
V D
Sbjct: 7674 QVSD 7677
Score = 63.2 bits (152), Expect = 1e-09
Identities = 46/172 (26%), Positives = 76/172 (44%), Gaps = 7/172 (4%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
+K+ T + SA + G+ I W +++ IL+ D I+ +L I V
Sbjct: 5052 KKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVD 5111
Query: 313 TTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTA----SLRCHAEGIP 368
H G YTC A V + + F + P V +A+ VT +L C G P
Sbjct: 5112 NGHSGRYTCQAKNESGVERCYAFLLVQEPAQIV---EKAKSVDVTEKDPMTLECVVAGTP 5168
Query: 369 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ ++ WLK+G I P ++ + N + I +V +D+G YT +N+ G
Sbjct: 5169 ELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFG 5220
Score = 60.5 bits (145), Expect = 7e-09
Identities = 66/287 (22%), Positives = 116/287 (40%), Gaps = 26/287 (9%)
Query: 171 DDISRKKLLVDQMFKYFDADSNGLVDINE-LTQVIKQEELGKDLFDCTLYVLLKYDDFN- 228
++IS+K L +++ K +A S + + E ++V+ EE+ K +L + +++
Sbjct: 32970 EEISQKALRSEEI-KMSEAKSQEKLALKEEASKVLISEEVKKSAAT-SLEKSIVHEEITK 33027
Query: 229 ---ADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN 285
A + + +AF Q+S+ E Q+L + A G + V W N
Sbjct: 33028 TSQASEEVRTHAEIKAFST-QMSINEGQRLVLKANIAGATDVK-------------WVLN 33073
Query: 286 NIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQ-----THIFQVNVP 340
+ L N + G D +L I + + G TC + E + + T +++
Sbjct: 33074 GVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLSKELSDA 33133
Query: 341 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHI 400
P P SQ G C G P P++ W KN + I+ + ++ N + I
Sbjct: 33134 PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEI 33193
Query: 401 SNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWREEG 447
N D+G YT AKN G +SL V + ++ R G
Sbjct: 33194 RNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSG 33240
Score = 60.1 bits (144), Expect = 8e-09
Identities = 45/185 (24%), Positives = 89/185 (48%), Gaps = 5/185 (2%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRN-NIILNNLDLEDINDFGDDG-SLYITK 310
+KL A +G S VL C + G+ + W ++ N I++ + + F ++ +L ++
Sbjct: 6745 RKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQ--SSFSENVCTLNLSL 6802
Query: 311 VTTTHVGNYTCYADGYEQVYQ-THIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ + G YTC A + + + V PP P+S PG++ + G P
Sbjct: 6803 LEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPP 6862
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
++ W K ++ P S ++L+ +E+ + V+ ++G Y+C+ N+AG + LF
Sbjct: 6863 FKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLF 6922
Query: 430 VEDSA 434
V++ A
Sbjct: 6923 VKEPA 6927
Score = 59.3 bits (142), Expect = 1e-08
Identities = 47/183 (25%), Positives = 71/183 (38%), Gaps = 3/183 (1%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
+K+ +G A +C IQ W + + D I SL I +
Sbjct: 3460 RKIEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQ 3519
Query: 313 TTHVGNYTCYADG-YEQVYQTHIFQVN--VPPVIRVYPESQAREPGVTASLRCHAEGIPK 369
G YTC A Y V T V PP P+S G A C G P
Sbjct: 3520 VVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPKSLTTFVGKAAKFICTVTGTPV 3579
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
+ W K+G ++P + +++ N + +SN+ +D G Y+C A N+ G D + L
Sbjct: 3580 IETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGADICQAELI 3639
Query: 430 VED 432
+ D
Sbjct: 3640 IID 3642
Score = 59.3 bits (142), Expect = 1e-08
Identities = 46/175 (26%), Positives = 74/175 (42%), Gaps = 6/175 (3%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC- 321
G + L QG+ I W + N L + I + SL + V T+ G YTC
Sbjct: 4220 GSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCK 4279
Query: 322 ---YADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 378
A G E ++F + SQ + G L C G P ++ W N
Sbjct: 4280 VSNVAGGVE--CSANLFVKEPATFVEKLEPSQLLKKGDATQLACKVTGTPPIKITWFAND 4337
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 433
+I +++ + + + +++V ED+G Y C A+NEAG D S + V++S
Sbjct: 4338 REIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKES 4392
Score = 58.9 bits (141), Expect = 2e-08
Identities = 47/176 (26%), Positives = 74/176 (42%), Gaps = 1/176 (0%)
Query: 260 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNY 319
+ V + L C I G+L + W ++ + D I SL I +V GN+
Sbjct: 4124 SVVNGTCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRVDMNDAGNF 4183
Query: 320 TCYA-DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNG 378
TC A + + V PP P S+ PG L+ +G + W K
Sbjct: 4184 TCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRWFKGN 4243
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSA 434
++ S +T +A S + + V+ D+G YTC N AG E ++LFV++ A
Sbjct: 4244 KELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEPA 4299
Score = 58.9 bits (141), Expect = 2e-08
Identities = 42/175 (24%), Positives = 71/175 (40%), Gaps = 3/175 (1%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G S+ L C I G+ ++W RN L D + + + ++T G++ C
Sbjct: 5438 GDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICE 5497
Query: 323 ADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 380
A T + V PPV +P SL C G P ++ W K+
Sbjct: 5498 AQNPAGSTSCSTKVI-VKEPPVFSSFPPIVETLKNAEVSLECELSGTPPFEVVWYKDKRQ 5556
Query: 381 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR 435
+ ++ + + +HI NV D G Y C A+NE G D + ++ +++ R
Sbjct: 5557 LRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPR 5611
Score = 58.5 bits (140), Expect = 2e-08
Identities = 41/185 (22%), Positives = 77/185 (41%), Gaps = 5/185 (2%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNI-ILNNLDLEDINDFGDDG-SLYITK 310
++L T +G S +L C + G+ + W I++ + F D+ +L +
Sbjct: 5804 RRLKNTGGVLGASCILECKVAGSSPISVAWFHEKTKIVSGAKYQ--TTFSDNVCTLQLNS 5861
Query: 311 VTTTHVGNYTCYADGYEQVYQTH-IFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ ++ +GNYTC A + + V PP PE PG + G P
Sbjct: 5862 LDSSDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEVLPGKNVTFTSVIRGTPP 5921
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
++ W + ++ + + +E+ + N+ +G YTC+ N AG + LF
Sbjct: 5922 FKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLF 5981
Query: 430 VEDSA 434
V++ A
Sbjct: 5982 VKEPA 5986
Score = 58.2 bits (139), Expect = 3e-08
Identities = 44/184 (23%), Positives = 72/184 (39%), Gaps = 4/184 (2%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
+K TVG++ L C + GT + W ++ +L + + + SL I V
Sbjct: 5708 EKAGPMTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVE 5767
Query: 313 TTHVGNYTCYA-DGYEQVYQTHIFQVN---VPPVIRVYPESQAREPGVTASLRCHAEGIP 368
G YT + + T + V+ VPP ++ G + L C G
Sbjct: 5768 RQDAGTYTFQVQNNVGKSSCTAVVDVSDRAVPPSFTRRLKNTGGVLGASCILECKVAGSS 5827
Query: 369 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSL 428
+ W I Q T N + ++++ D G YTC+A N AG DE + L
Sbjct: 5828 PISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAGSDECRAVL 5887
Query: 429 FVED 432
V++
Sbjct: 5888 TVQE 5891
Score = 58.2 bits (139), Expect = 3e-08
Identities = 54/237 (22%), Positives = 87/237 (36%), Gaps = 34/237 (14%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
TVG V CAI G+ + W ++ L + + + +L I K + G Y+
Sbjct: 8069 TVGLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYS 8128
Query: 321 CYADG------------YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 368
C A + F + + PV V ES A CH G
Sbjct: 8129 CTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGES--------ADFECHVTGTQ 8180
Query: 369 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDE----- 423
++ W K+ +I Q++ N + + + V D+G YTC A NE G D
Sbjct: 8181 PIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQL 8240
Query: 424 DISSLFVEDSARKTLANILWREEG---------LGIGNMFYVFYEDGIKVIQPIECE 471
+I + S K L+ + EG G + +Y++ I++ CE
Sbjct: 8241 NIKERLIPPSFTKRLSETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCE 8297
Score = 55.5 bits (132), Expect = 2e-07
Identities = 42/161 (26%), Positives = 61/161 (37%), Gaps = 5/161 (3%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
GQS C I GT + + W + + + I+ + I+ + G Y C
Sbjct: 4876 GQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCE 4935
Query: 323 ADGYEQVYQTHI-FQVNVPPVI--RVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
A I +V PP + P + V L C G P ++ WLKN
Sbjct: 4936 ARNDAGTASCSIELKVKEPPTFIRELKPVEVVKYSDV--ELECEVTGTPPFEVTWLKNNR 4993
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+I LT + + +HI+ DTG Y CI NE G
Sbjct: 4994 EIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGG 5034
Score = 55.5 bits (132), Expect = 2e-07
Identities = 40/173 (23%), Positives = 72/173 (41%), Gaps = 2/173 (1%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
+G+S C + GT I W ++N + + + +L + KV G YTC
Sbjct: 7225 LGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTC 7284
Query: 322 YADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
YA + + P I+ S+ + C G P+ ++ W K+
Sbjct: 7285 YASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDET 7344
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
+I +++ + + + + N+ ED+G YTC A N AG +SL V++
Sbjct: 7345 EIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKE 7397
Score = 55.5 bits (132), Expect = 2e-07
Identities = 50/202 (24%), Positives = 82/202 (40%), Gaps = 5/202 (2%)
Query: 235 LEEFYRAFQVIQLSLPEDQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDL 294
++E + V++ + ++ SI T G + L C + GT W ++ L + +
Sbjct: 7573 MQECFATLSVLEPATIVEKPESIKVTT-GDTCTLECTVAGTPELSTKWFKDGKELTSDNK 7631
Query: 295 EDINDFGDDGSLYITKVTTTHVGNYTCYADG-YEQVYQTHIFQVN---VPPVIRVYPESQ 350
I+ F L I V + G Y+ + T QV+ VPP +
Sbjct: 7632 YKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLKET 7691
Query: 351 AREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGA 410
G + + C G P + W G +I+ Q TL N + ++ + D+G
Sbjct: 7692 NGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALTVNMLEESDSGD 7751
Query: 411 YTCIAKNEAGVDEDISSLFVED 432
YTCIA N AG DE + L V +
Sbjct: 7752 YTCIATNMAGSDECSAPLTVRE 7773
Score = 55.1 bits (131), Expect = 3e-07
Identities = 52/217 (23%), Positives = 91/217 (41%), Gaps = 10/217 (4%)
Query: 207 EELGKDLFDCTLYVLLKYDDFNADKHLALEEFYRAFQVIQLSLPEDQKLSITAATVGQSA 266
E L + DC Y +++ + A A+ LS P+ S+T VG++A
Sbjct: 3514 EILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEAYPPTFLSRPK----SLTTF-VGKAA 3568
Query: 267 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGY 326
C + GT IW+++ L+ I+D + L ++ +T G Y+C A
Sbjct: 3569 KFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNK 3628
Query: 327 --EQVYQTHIFQVNVPPVIR-VYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP 383
+ Q + ++ P I+ + P A V L C + K + W K+G + P
Sbjct: 3629 FGADICQAELIIIDKPHFIKELEPVQSAINKKV--HLECQVDEDRKVTVTWSKDGQKLPP 3686
Query: 384 KLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
++ + + + I + +D+G Y C A NEAG
Sbjct: 3687 GKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAG 3723
Score = 54.7 bits (130), Expect = 4e-07
Identities = 39/175 (22%), Positives = 72/175 (41%), Gaps = 3/175 (1%)
Query: 270 CAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA-DGYEQ 328
C I G+ ++W ++ + ++ L + ++ G+YTC A +
Sbjct: 7327 CKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGS 7386
Query: 329 VYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQ 388
+ +V PP+ R P G L C +G P + W K+ ++ +
Sbjct: 7387 ASSSTSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYK 7446
Query: 389 LTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR--KTLANI 441
+ + + +HI NV D G Y C A N+ G D + S+ ++ R K L++I
Sbjct: 7447 IMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDI 7501
Score = 54.7 bits (130), Expect = 4e-07
Identities = 45/200 (22%), Positives = 82/200 (41%), Gaps = 7/200 (3%)
Query: 241 AFQVIQLSLPED--QKLSITAATVGQSAVLSCAIQGTLRPPIIW--KRNNIILNNLDLED 296
+ QV ++P +KL T G S V+ C + G+ + W + N I
Sbjct: 7672 SLQVSDRTVPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTT 7731
Query: 297 INDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHI-FQVNVPPVIRVYPESQAREPG 355
+ D + +L + + + G+YTC A + V PP P+ G
Sbjct: 7732 LTD--NTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDVLTG 7789
Query: 356 VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIA 415
+ +G P + W K ++ P ++L+ + +E+ + +V +G YTCI
Sbjct: 7790 TNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIV 7849
Query: 416 KNEAGVDEDISSLFVEDSAR 435
NEAG + L+++ A+
Sbjct: 7850 SNEAGKASCTTHLYIKAPAK 7869
Score = 54.7 bits (130), Expect = 4e-07
Identities = 50/219 (22%), Positives = 84/219 (38%), Gaps = 7/219 (3%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G+ +L GT + WK+N I + +I L I T G Y CY
Sbjct: 7882 GKPLILEGTFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCY 7941
Query: 323 ---ADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
A G + + + PP E G +ASL+C G P+ + W K
Sbjct: 7942 IENASGKDSCSAQIL--ILEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDT 7999
Query: 380 DITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLA 439
+ P + ++ + N + + + V D+G Y C A+N G + L V++
Sbjct: 8000 KLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSF 8059
Query: 440 NILWREEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKP 478
+ R+ +G V ++ I +PI + + KP
Sbjct: 8060 SRQLRDVQETVG--LPVVFDCAISGSEPISVSWYKDGKP 8096
Score = 53.1 bits (126), Expect = 1e-06
Identities = 42/193 (21%), Positives = 78/193 (40%), Gaps = 3/193 (1%)
Query: 243 QVIQLSLPED--QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDF 300
+V+ ++P +KL+ +G S + C + G+L W ++ ++ +
Sbjct: 5229 RVLDQNIPPSFTKKLTKMDKVLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKYRLVCH 5288
Query: 301 GDDGSLYITKVTTTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTAS 359
SL + + NYTC + I V PP V P Q P T
Sbjct: 5289 ERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIPDSTVE 5348
Query: 360 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 419
+ +G P ++ W K+ +++ + L+ + S +++ +V TG YTC N+
Sbjct: 5349 FKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDV 5408
Query: 420 GVDEDISSLFVED 432
G D + L V +
Sbjct: 5409 GSDSCTTMLLVTE 5421
Score = 52.8 bits (125), Expect = 1e-06
Identities = 50/186 (26%), Positives = 76/186 (40%), Gaps = 4/186 (2%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
QK S A G +L C I GT ++W ++ + N I D SL+I +
Sbjct: 6462 QKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLE 6521
Query: 313 TTHVGNYTCYADGYEQVYQTHIFQVNV--PPVIRVYPESQAREPGVTASLRCHAEGIPKP 370
+ VG Y C A E T V PP + G LR EG
Sbjct: 6522 ASDVGEYHCKATN-EVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPI 6580
Query: 371 QLGWLKN-GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
+ WLK+ G I + +++ N + + + + ++G Y C KN+AG+ E + L
Sbjct: 6581 SVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLT 6640
Query: 430 VEDSAR 435
V + AR
Sbjct: 6641 VLEPAR 6646
Score = 52.0 bits (123), Expect = 2e-06
Identities = 41/170 (24%), Positives = 74/170 (43%), Gaps = 3/170 (1%)
Query: 268 LSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYA--DG 325
L C + GT + W +NN + + + D +L+ITK + G Y C +G
Sbjct: 4974 LECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEG 5033
Query: 326 YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKL 385
T + P I+ E+ +A+ + G P + WLK+ +
Sbjct: 5034 GSCSCSTRVALKEPPSFIKKI-ENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDD 5092
Query: 386 SKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR 435
+ ++ + + + I +V +G YTC AKNE+GV+ + L V++ A+
Sbjct: 5093 NVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQ 5142
Score = 51.6 bits (122), Expect = 3e-06
Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 6/185 (3%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDG--SLYITK 310
Q L G +A I G P + W R+ +++ L + DG L I
Sbjct: 10 QPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPA 69
Query: 311 VTTTHVGNYTCYA-DGYEQVYQTHIFQVNV---PPVIRVYPESQAREPGVTASLRCHAEG 366
VT + G Y+ A +G Q T V PP +S G L+ G
Sbjct: 70 VTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTG 129
Query: 367 IPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDIS 426
IP P + + ++G +I L Q++ + + + I+ ED+G Y+ A N G +
Sbjct: 130 IPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTA 189
Query: 427 SLFVE 431
L V+
Sbjct: 190 ELLVQ 194
Score = 51.6 bits (122), Expect = 3e-06
Identities = 41/160 (25%), Positives = 64/160 (40%), Gaps = 3/160 (1%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G+SA L C ++G+ + W +NN L+ + + + L IT V G+Y+C
Sbjct: 3752 GESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILDITDVKVEDSGSYSCE 3811
Query: 323 A--DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 380
A D T I P I+ + G A L+C G ++ W K+
Sbjct: 3812 AVNDVGSDSCSTEIVIKEPPSFIKTLEPADIVR-GTNALLQCEVSGTGPFEISWFKDKKQ 3870
Query: 381 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
I +L Q + + I + D G Y C+ NE G
Sbjct: 3871 IRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECVVANEVG 3910
Score = 51.6 bits (122), Expect = 3e-06
Identities = 45/175 (25%), Positives = 75/175 (42%), Gaps = 7/175 (4%)
Query: 267 VLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDG--SLYITKVTTTHVGNYTCYAD 324
+L + GT I W ++N IL + F D SL I K G Y C
Sbjct: 4411 MLLAEVAGTPPFEITWFKDNTILRSG--RKYKTFIQDHLVSLQILKFVAADAGEYQCRVT 4468
Query: 325 GY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDIT 382
+ + + PP ES + G TA+ + +G + WLK+ +IT
Sbjct: 4469 NEVGSSICSARV-TLREPPSFIKKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEIT 4527
Query: 383 PKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKT 437
+ ++T + N + +++S + + G Y C AKN+AG+ + L V++ A T
Sbjct: 4528 EDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCSALLSVKEPATIT 4582
Score = 51.6 bits (122), Expect = 3e-06
Identities = 39/169 (23%), Positives = 65/169 (38%), Gaps = 1/169 (0%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
++LS + G+S +L GTL + WK++ + + +I L I T
Sbjct: 5990 KRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTEKTCILEILNST 6049
Query: 313 TTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 371
G Y+C + + + PP E G + SL+C G P+
Sbjct: 6050 KRDAGQYSCEIENEAGRDVCGALVSTLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEIT 6109
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ W K + P + N + + + V D+G YTC A+N G
Sbjct: 6110 VSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIG 6158
Score = 51.2 bits (121), Expect = 4e-06
Identities = 23/66 (34%), Positives = 34/66 (51%)
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
G + +L CH G P P + W + I + Q+T Q+ + + I ED+G +TC
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 415 AKNEAG 420
A NEAG
Sbjct: 1017 AVNEAG 1022
Score = 51.2 bits (121), Expect = 4e-06
Identities = 46/177 (25%), Positives = 68/177 (38%), Gaps = 6/177 (3%)
Query: 261 TVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYT 320
T G L C + GT W ++ L+ I SL I + G Y+
Sbjct: 6657 TTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYS 6716
Query: 321 CYADGY----EQVYQTHIFQVNVPP-VIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL 375
H+ VPP IR + A G + L C G +GW
Sbjct: 6717 FEVKNSVGKSNCTVSVHVSDRIVPPSFIRKLKDVNAIL-GASVVLECRVSGSAPISVGWF 6775
Query: 376 KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
++G +I Q + N +++S + DTG YTC+A N AG DE + L V++
Sbjct: 6776 QDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQE 6832
Score = 50.8 bits (120), Expect = 5e-06
Identities = 24/93 (25%), Positives = 50/93 (53%)
Query: 340 PPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVH 399
P ++ S PG +A L C +G P Q+ W KN +++ + ++ + + +
Sbjct: 3737 PSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAILD 3796
Query: 400 ISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
I++V+ ED+G+Y+C A N+ G D + + +++
Sbjct: 3797 ITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKE 3829
Score = 50.4 bits (119), Expect = 7e-06
Identities = 42/194 (21%), Positives = 80/194 (41%), Gaps = 7/194 (3%)
Query: 244 VIQLSLPED--QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG 301
V+ L +P +KL + G L C + G+ I W +++ ++ + +
Sbjct: 4668 VLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHD 4727
Query: 302 DDGSLYITKVTTTHVGNYTCYAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTA 358
+ L I+++ T G YTC A G+ Q H+ V PP P+SQ P
Sbjct: 4728 NTAFLEISQLEGTDSGTYTCSATNKAGHNQC-SGHL-TVKEPPYFVEKPQSQDVNPNTRV 4785
Query: 359 SLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNE 418
L+ G + W K+ ++ ++ + + + + + D+G Y C N+
Sbjct: 4786 QLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLSND 4845
Query: 419 AGVDEDISSLFVED 432
G ++LFV++
Sbjct: 4846 VGTATSKATLFVKE 4859
Score = 50.4 bits (119), Expect = 7e-06
Identities = 38/170 (22%), Positives = 68/170 (40%), Gaps = 3/170 (1%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G + + ++GT + W + + L D +++ L + V T+ G YTC
Sbjct: 7789 GTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCI 7848
Query: 323 A--DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 380
+ + TH++ + P + E G L G P + W KNGI+
Sbjct: 7849 VSNEAGKASCTTHLY-IKAPAKFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGIN 7907
Query: 381 ITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
+TP +T + + I + ED G Y C +N +G D + + +
Sbjct: 7908 VTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILI 7957
Score = 49.7 bits (117), Expect = 1e-05
Identities = 26/107 (24%), Positives = 54/107 (50%), Gaps = 3/107 (2%)
Query: 338 NVPPVIRVYPE---SQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQAN 394
NVPP++ PE + G + ++ +G P P++ W K+G++I +++ ++T
Sbjct: 27953 NVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLG 28012
Query: 395 GSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANI 441
+ + + + + G YT AKN +G + + V+D+ K + I
Sbjct: 28013 STSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPI 28059
Score = 49.3 bits (116), Expect = 2e-05
Identities = 36/169 (21%), Positives = 74/169 (43%), Gaps = 1/169 (0%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
+K+ T++ G +A ++G+L + W +++ + D + + SLY++ +
Sbjct: 4490 KKIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIE 4549
Query: 313 TTHVGNYTCYADGYEQVYQ-THIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 371
H G Y C A + + + + V P I S G A+L+ G +
Sbjct: 4550 VKHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEIT 4609
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
W K+G ++T ++++ S + I + +D+G YT +N+ G
Sbjct: 4610 AKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVG 4658
Score = 49.3 bits (116), Expect = 2e-05
Identities = 39/186 (20%), Positives = 70/186 (37%), Gaps = 4/186 (2%)
Query: 260 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNY 319
A VG S L C + GT + W + + L + +L KV G Y
Sbjct: 6090 AAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEY 6149
Query: 320 TCYADGYEQVYQTH-IFQVN---VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL 375
TC A+ + +F++ +PP + + G+ +L C G Q+ W
Sbjct: 6150 TCKAENSIGTASSKTVFRIQERQLPPSFARQLKDIEQTVGLPVTLTCRLNGSAPIQVCWY 6209
Query: 376 KNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR 435
++G+ + + Q + N + + I +G Y+C A N G + L + +
Sbjct: 6210 RDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKK 6269
Query: 436 KTLANI 441
+I
Sbjct: 6270 SPFFDI 6275
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/179 (22%), Positives = 80/179 (44%), Gaps = 6/179 (3%)
Query: 256 SITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTH 315
+I +TV A+L +GT I W ++++ L + I G L + V +
Sbjct: 5341 AIPDSTVEFKAIL----KGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASK 5396
Query: 316 VGNYTCYA--DGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLG 373
G YTC+ D T + P ++ S+ + G ++ L C G P+ ++
Sbjct: 5397 TGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVV 5456
Query: 374 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
W +N ++ ++T + + + ++N+ ED+G + C A+N AG + + V++
Sbjct: 5457 WFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKE 5515
Score = 48.1 bits (113), Expect = 3e-05
Identities = 40/191 (20%), Positives = 79/191 (41%), Gaps = 13/191 (6%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
+K+ A GQ+ L A++G+ + W + ++ ++ L I V
Sbjct: 3928 KKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQ 3987
Query: 313 TTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQARE--PGVTASLRCHAEGIPKP 370
+ G YTC A+ E QT + ++ V ++ ++ + G A+L G P+
Sbjct: 3988 ISFGGKYTCLAEN-EAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPEL 4046
Query: 371 QLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG---------- 420
+ W K+G + +++ + N +++ + D+G YT NE G
Sbjct: 4047 KPKWYKDGRPLVASKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTV 4106
Query: 421 VDEDISSLFVE 431
+D DI+ F +
Sbjct: 4107 LDRDIAPFFTK 4117
Score = 47.4 bits (111), Expect = 6e-05
Identities = 40/185 (21%), Positives = 74/185 (40%), Gaps = 3/185 (1%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
++L+ + G VL GT + W ++ +++ + I L I + T
Sbjct: 6931 KRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILEST 6990
Query: 313 TTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 371
Y+C + Q + V PP E G A+L+C +G P+ +
Sbjct: 6991 IEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIR 7050
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
+ W K + + ++ + N + + I+ V + D G Y+C A N G + L ++
Sbjct: 7051 ISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIK 7110
Query: 432 DSARK 436
ARK
Sbjct: 7111 --ARK 7113
Score = 47.0 bits (110), Expect = 7e-05
Identities = 38/182 (20%), Positives = 70/182 (38%), Gaps = 2/182 (1%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKV 311
+KLS T+ +G + L ++G ++W K ++ + I+ + +L +
Sbjct: 6555 KKLSDTSTLIGDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSP 6614
Query: 312 TTTHVGNYTCYADGYEQVYQ-THIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKP 370
++ G Y C + + + + V P I PE G +L C G P+
Sbjct: 6615 EASNSGKYICQIKNDAGMRECSAVLTVLEPARIIEKPEPMTVTTGNPFALECVVTGTPEL 6674
Query: 371 QLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFV 430
W K+G +++ +T + + I D G Y+ KN G S+ V
Sbjct: 6675 SAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV 6734
Query: 431 ED 432
D
Sbjct: 6735 SD 6736
Score = 47.0 bits (110), Expect = 7e-05
Identities = 26/91 (28%), Positives = 39/91 (42%)
Query: 341 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHI 400
P IR + + G A L C G P P + W + G ++ +++ + +
Sbjct: 30533 PGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTV 30592
Query: 401 SNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
ED G YTCIA NE G E S L ++
Sbjct: 30593 MTEEQEDEGVYTCIATNEVGEVETSSKLLLQ 30623
Score = 46.6 bits (109), Expect = 1e-04
Identities = 43/185 (23%), Positives = 68/185 (36%), Gaps = 6/185 (3%)
Query: 254 KLSITAATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKVT 312
KL+ G+ A L +I+G + W K ++ + I + +L K
Sbjct: 5615 KLNSLTVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAE 5674
Query: 313 TTHVGNYTCYAD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPK 369
+ G Y C G + T V P VI G T +L C G P+
Sbjct: 5675 PANAGKYICQIKNDGGMRENMAT--LMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPE 5732
Query: 370 PQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLF 429
+ W K+G +T + + S + I +V +D G YT +N G + +
Sbjct: 5733 LSVEWYKDGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVD 5792
Query: 430 VEDSA 434
V D A
Sbjct: 5793 VSDRA 5797
Score = 45.1 bits (105), Expect = 3e-04
Identities = 27/105 (25%), Positives = 45/105 (42%)
Query: 327 EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLS 386
E+ T + + I P S G +A C +G P P + WL+ G ++
Sbjct: 32547 EEKSTTRKIKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSAR 32606
Query: 387 KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
Q+T S IS+V+ D G Y+ + +N G E +L ++
Sbjct: 32607 HQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQ 32651
Score = 44.3 bits (103), Expect = 5e-04
Identities = 44/194 (22%), Positives = 73/194 (37%), Gaps = 17/194 (8%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIW-KRNNIILNNLDLEDINDFGDDGSLYITKV 311
Q+L G+ A I G +P I W K ++ + ++D G + +L + +
Sbjct: 3243 QELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHD-GQEYTLLLIEA 3301
Query: 312 TTTHVGNYTCYA-DGYEQVYQTHIFQVNVPPVIR------VYP-------ESQAREPGVT 357
YTC A + Y + V VP V+ VYP + G
Sbjct: 3302 FPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDTVTSEGQP 3361
Query: 358 ASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 417
A +C G ++ W I P ++T + ++ I+ ED G YT +A N
Sbjct: 3362 ARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGTYTFVASN 3420
Query: 418 EAGVDEDISSLFVE 431
G ++L +E
Sbjct: 3421 AVGQVSSTANLSLE 3434
Score = 44.3 bits (103), Expect = 5e-04
Identities = 44/177 (24%), Positives = 72/177 (40%), Gaps = 7/177 (3%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G +A+L C + GT I W ++ + + + L I + VG Y C
Sbjct: 3845 GTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECV 3904
Query: 323 AD---GYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGI 379
G TH+ + PP + G T +L+ G + W+K G
Sbjct: 3905 VANEVGKCGCMATHLLKE--PPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMK-GQ 3961
Query: 380 DITPKLSKQLTLQANGSEVHI-SNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSAR 435
++ + K +NG V I +V+ G YTC+A+NEAG + L V++ A+
Sbjct: 3962 EVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVKEPAK 4018
Score = 43.5 bits (101), Expect = 8e-04
Identities = 33/105 (31%), Positives = 51/105 (48%), Gaps = 5/105 (4%)
Query: 341 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE-VH 399
P I +YPE G TA RC G P+P++ W NG I + SK+ ++ +G +
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLI--RKSKRFRVRYDGIHYLD 1898
Query: 400 ISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLANILWR 444
I + + DTG A+N GV E L ++ R+ ++L R
Sbjct: 1899 IVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQ--REDFRSVLRR 1941
Score = 42.7 bits (99), Expect = 0.001
Identities = 35/172 (20%), Positives = 60/172 (34%), Gaps = 4/172 (2%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
++L +VG SA L C + GT + W + + L ++ + +L +V
Sbjct: 7965 KQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVD 8024
Query: 313 TTHVGNYTCYADGYEQVYQTHIF----QVNVPPVIRVYPESQAREPGVTASLRCHAEGIP 368
G Y C A+ F + +PP G+ C G
Sbjct: 8025 INDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSRQLRDVQETVGLPVVFDCAISGSE 8084
Query: 369 KPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ W K+G + + Q + N + ++I G Y+C A N G
Sbjct: 8085 PISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIG 8136
Score = 42.4 bits (98), Expect = 0.002
Identities = 44/199 (22%), Positives = 67/199 (33%), Gaps = 21/199 (10%)
Query: 255 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 314
L T + GQ A C + GT + W + + + F D L I +
Sbjct: 3351 LQDTVTSEGQPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPE 3409
Query: 315 HVGNYTCYADG--------------------YEQVYQTHIFQVNVPPVIRVYPESQAREP 354
G YT A +E++ Q ++ PVI+ E
Sbjct: 3410 DEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVAL 3469
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
G A C + P + W K G +I + S + I + D G YTC
Sbjct: 3470 GHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCK 3529
Query: 415 AKNEAGVDEDISSLFVEDS 433
A NE G ++L V ++
Sbjct: 3530 ASNEYGSVSCTATLTVTEA 3548
Score = 41.2 bits (95), Expect = 0.004
Identities = 39/161 (24%), Positives = 59/161 (36%), Gaps = 1/161 (0%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G++ + I+GT + W R L D +I L + + + G YTC
Sbjct: 5907 GKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCV 5966
Query: 323 -ADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDI 381
++ Q T V P + EPG + L G + W K+G +I
Sbjct: 5967 VSNNAGQASCTTRLFVKEPAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNI 6026
Query: 382 TPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVD 422
T + + I N D G Y+C +NEAG D
Sbjct: 6027 TTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRD 6067
Score = 40.8 bits (94), Expect = 0.005
Identities = 41/175 (23%), Positives = 68/175 (38%), Gaps = 4/175 (2%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G L C +QGT + W ++ L + I S++I V +G Y C
Sbjct: 7413 GADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCK 7472
Query: 323 ADGYEQVYQTHIFQV--NVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGID 380
A + T + + PP + G L+ EG + W K+ +
Sbjct: 7473 ATN-DVGSDTCVGSIALKAPPRFVKKLSDISTVVGKEVQLQTTIEGAEPISVVWFKDKGE 7531
Query: 381 ITPKLSK-QLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSA 434
I + ++ N + + S V + G YTC KN+AG+ E ++L V + A
Sbjct: 7532 IVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLSVLEPA 7586
Score = 40.8 bits (94), Expect = 0.005
Identities = 36/162 (22%), Positives = 68/162 (41%), Gaps = 7/162 (4%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFG-DDGSLYITKVTTTHVGNYTC 321
G S ++ ++ P W R N + + E+ G ++ + Y + N +
Sbjct: 19217 GGSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIARTAVNISP 19276
Query: 322 YADGYEQVYQTHIFQVNVPPVIRVYPESQAR---EPGVTASLRCHAEGIPKPQLGWLKNG 378
++ + V I NVPP I + ++ + G L G P P + W K+G
Sbjct: 19277 PSEPSDPVT---ILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDG 19333
Query: 379 IDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ P ++ +Q N + + +V +D+G YT A+N +G
Sbjct: 19334 TLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSG 19375
Score = 40.8 bits (94), Expect = 0.005
Identities = 48/189 (25%), Positives = 72/189 (38%), Gaps = 20/189 (10%)
Query: 260 ATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLY---ITKVTTTHV 316
A VG++ I P + W ++ + D + F D LY I VTT
Sbjct: 31701 AYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDD 31760
Query: 317 GNYTCYAD---GYEQVYQTHIFQVNVPPVI--------RVYPESQAREPGVTASLRCHAE 365
YT A G + ++ PP R+ ++ +E G +
Sbjct: 31761 AEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQE-GQSVCFEIRVS 31819
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSE---VHISNVRYEDTGAYTCIAKNEAGVD 422
GIP P L W K+G ++ L + + G + +HI + EDTG Y A N AG
Sbjct: 31820 GIPPPTLKWEKDGQPLS--LGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGST 31877
Query: 423 EDISSLFVE 431
+ L VE
Sbjct: 31878 SCQAHLQVE 31886
Score = 40.4 bits (93), Expect = 0.007
Identities = 52/239 (21%), Positives = 94/239 (39%), Gaps = 41/239 (17%)
Query: 341 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE-VH 399
PV + P S G TA G P P+ W +G I + ++ ++ +G++ +
Sbjct: 1457 PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLI 1516
Query: 400 ISNVRYEDTGAYTCIAKNEAG------------VDEDISSLFVEDSAR---KTLANILWR 444
I D+G +T +A+N AG V+ + +FVE K + + +
Sbjct: 1517 IVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMK 1576
Query: 445 EEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEGDEVQRCVWA 504
G N V+ ++ +I P H P ++ G + E K + Q W
Sbjct: 1577 VRATGNPNPDIVWLKNS-DIIVP-------HKYPKIRIEGTKGEAALKIDSTVSQDSAWY 1628
Query: 505 SA--------------VNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVPVKLHY 549
+A VNV+ +F A+P +R LI+ + + + + + P+ L Y
Sbjct: 1629 TATAINKAGRDTTRCKVNVEVEF---AEPEPERKLIIPRGTYRAKEIAAPELEPLHLRY 1684
Score = 40.4 bits (93), Expect = 0.007
Identities = 40/178 (22%), Positives = 68/178 (38%), Gaps = 9/178 (5%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNI-ILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
GQ+A + G P W + I+N+ + + SL I T + G +T
Sbjct: 1471 GQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTV 1530
Query: 322 YADG------YEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWL 375
A + + V P+ ++ + G ++ A G P P + WL
Sbjct: 1531 VAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWL 1590
Query: 376 KNGIDITPKLSKQLTLQANGSE--VHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
KN I P ++ ++ E + I + +D+ YT A N+AG D + VE
Sbjct: 1591 KNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE 1648
Score = 40.0 bits (92), Expect = 0.009
Identities = 27/140 (19%), Positives = 56/140 (40%), Gaps = 5/140 (3%)
Query: 279 PIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVN 338
P+ W ++ + D + L + ++ + G YT E + + ++
Sbjct: 2824 PVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYTAVVGQLECKAKLFVETLH 2883
Query: 339 VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEV 398
+ ++ + + TAS C P + WLKNG++I ++ +Q ++
Sbjct: 2884 ITKTMKNIEVPETK----TASFECEVSHFNVPSM-WLKNGVEIEMSEKFKIVVQGKLHQL 2938
Query: 399 HISNVRYEDTGAYTCIAKNE 418
I N ED+ YT + N+
Sbjct: 2939 IIMNTSTEDSAEYTFVCGND 2958
Score = 39.7 bits (91), Expect = 0.012
Identities = 25/84 (29%), Positives = 34/84 (40%)
Query: 337 VNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 396
++ PVI + A A G P+P W K+G IT +L+ G
Sbjct: 32848 ISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGF 32907
Query: 397 EVHISNVRYEDTGAYTCIAKNEAG 420
+ I D+G YTC KN AG
Sbjct: 32908 FLEIHKTDTSDSGLYTCTVKNSAG 32931
Score = 39.3 bits (90), Expect = 0.016
Identities = 41/164 (25%), Positives = 60/164 (36%), Gaps = 6/164 (3%)
Query: 255 LSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTT 314
L T G++A C + P+ W L D G +L + V
Sbjct: 12202 LKDVTVTAGETATFDCELSYE-DIPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLE 12260
Query: 315 HVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYP-ESQAREPGVTASLRCHAEGIPKPQLG 373
G A ++ ++F V PPV P E Q E G TA L C ++
Sbjct: 12261 DAGEVQLTAKDFKT--HANLF-VKEPPVEFTKPLEDQTVEEGATAVLECEVSR-ENAKVK 12316
Query: 374 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKN 417
W KNG +I ++ ++ I + ED YTC AK+
Sbjct: 12317 WFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKD 12360
Score = 39.3 bits (90), Expect = 0.016
Identities = 22/96 (22%), Positives = 44/96 (45%), Gaps = 1/96 (1%)
Query: 337 VNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGS 396
+ + P +++ + + + G + G P+P + W+K+G + + A +
Sbjct: 24308 LTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATST 24367
Query: 397 EVHISNVRYEDTGAYTCIAKNEAG-VDEDISSLFVE 431
+HI +D G YT A N AG E++S + +E
Sbjct: 24368 VLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLE 24403
Score = 38.9 bits (89), Expect = 0.020
Identities = 25/93 (26%), Positives = 38/93 (40%), Gaps = 2/93 (2%)
Query: 341 PVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITP--KLSKQLTLQANGSEV 398
P P Q G + C G PKP + W K+G+ +T + Q ++
Sbjct: 1082 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1141
Query: 399 HISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
IS +D G YT + +N+ G +SL E
Sbjct: 1142 VISMTFADDAGEYTIVVRNKHGETSASASLLEE 1174
Score = 38.9 bits (89), Expect = 0.020
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 1/81 (1%)
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLT-LQANGSEVHISNVRYEDTGAYTC 413
G+ + C G P P++ W K+G I Q+ LQ + + I V ED G YT
Sbjct: 1305 GMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTA 1364
Query: 414 IAKNEAGVDEDISSLFVEDSA 434
A N G L+VE +A
Sbjct: 1365 FASNIKGNAICSGKLYVEPAA 1385
Score = 38.5 bits (88), Expect = 0.026
Identities = 40/156 (25%), Positives = 67/156 (42%), Gaps = 15/156 (9%)
Query: 279 PIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVN 338
P +W +N + + + I G L I +T YT + G +QV T +
Sbjct: 2911 PSMWLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYT-FVCGNDQVSAT----LT 2965
Query: 339 VPPVI--RVYPESQAREPG-VTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANG 395
V P++ + + A E +T + + EGI WLKNG++I Q+ +
Sbjct: 2966 VTPIMITSMLKDINAEEKDTITFEVTVNYEGI---SYKWLKNGVEIKSTDKCQMRTKKLT 3022
Query: 396 SEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
++I NV + D YT + AG ++L+VE
Sbjct: 3023 HSLNIRNVHFGDAADYTFV----AGKATSTATLYVE 3054
Score = 38.1 bits (87), Expect = 0.035
Identities = 80/369 (21%), Positives = 140/369 (37%), Gaps = 67/369 (18%)
Query: 252 DQKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKV 311
DQ L+ + G+ LSC +QG+ I W + + D + L + V
Sbjct: 8349 DQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDV 8408
Query: 312 TTTHVGNYTCYADGY-----------------------EQVYQTHIFQVNVPPVIRVYPE 348
G+Y C A + +F V+ P IRV +
Sbjct: 8409 AKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEK 8468
Query: 349 SQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE--VHISNVRYE 406
+ TA+ G P P + W K G ++ + G E + I +
Sbjct: 8469 T-------TATFIAKVGGDPIPNVKWTK-GKWRQLNQGGRVFIHQKGDEAKLEIRDTTKT 8520
Query: 407 DTGAYTCIAKNEAGVDEDISSLFVEDSARK-----TLANILWREEGL--GIGNMFYVFYE 459
D+G Y C+A NE G E +L V++ ++ L +L + L G G +
Sbjct: 8521 DSGLYRCVAFNEHGEIESNVNLQVDERKKQEKIEGDLRAMLKKTPILKKGAGEEEEIDIM 8580
Query: 460 DGIKVIQPIECE----------FQRHIKPSEKLLGFQDEVCPKAEGDEVQRC-----VWA 504
+ +K + P E E F+ ++ E L Q+E + E +E++R +
Sbjct: 8581 ELLKNVDPKEYEKYARMYGITDFRGLLQAFELLKQSQEEETHRLEIEEIERSERDEKEFE 8640
Query: 505 SAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQ-AVSTDPVPVKLHYDKSHDQVWVLSW-- 561
V+ + + +P LI D+++Q V++ + + +K++Y + LSW
Sbjct: 8641 ELVSFIQQRLSQTEPV---TLIKDIENQTVLKDNDAVFEIDIKINYPEIK-----LSWYK 8692
Query: 562 GTLEKTSPT 570
GT EK P+
Sbjct: 8693 GT-EKLEPS 8700
Score = 38.1 bits (87), Expect = 0.035
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 7/85 (8%)
Query: 340 PPVIRVYPESQAREP----GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANG 395
PP + + + ARE G T L +G+P P++ W K D K +T G
Sbjct: 17215 PPEL-ILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVT--PVG 17271
Query: 396 SEVHISNVRYEDTGAYTCIAKNEAG 420
S++ I N +ED G Y+ +N AG
Sbjct: 17272 SKLEIRNAAHEDGGIYSLTVENPAG 17296
Score = 37.7 bits (86), Expect = 0.045
Identities = 46/178 (25%), Positives = 66/178 (37%), Gaps = 11/178 (6%)
Query: 265 SAVLSCAIQGTLRPPIIWKRNN--IILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
+A L C + G +P + W R II + L G L I VT Y
Sbjct: 30944 NATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVR 31003
Query: 323 ADGYE-QVYQTHIFQVNVPPVIRVYPESQAREP-----GVTASLRCHAEGIPKPQLGWLK 376
A V T +V VP I + + G S++ G P P + W K
Sbjct: 31004 ATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPDPVITWQK 31063
Query: 377 NGIDITPKLS--KQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
G D+ + + ++ S V + V +D G Y AKN G+D+ L V D
Sbjct: 31064 -GQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDVAD 31120
Score = 37.4 bits (85), Expect = 0.059
Identities = 30/126 (23%), Positives = 49/126 (38%), Gaps = 1/126 (0%)
Query: 306 LYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE 365
++I++ + G YT A G + T PP + + + G A
Sbjct: 3205 MFISETRQSDAGEYTFVA-GRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVIS 3263
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDI 425
G P+P++ W K ++ + + + ED YTC AKN+ GV
Sbjct: 3264 GRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTS 3323
Query: 426 SSLFVE 431
+SL VE
Sbjct: 3324 ASLSVE 3329
Score = 37.4 bits (85), Expect = 0.059
Identities = 31/135 (22%), Positives = 54/135 (40%), Gaps = 11/135 (8%)
Query: 282 WKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVN--- 338
W + L D +I+ GD +L + GNY V HI
Sbjct: 8690 WYKGTEKLEPSDKFEISIDGDRHTLRVKNCQLKDQGNYRL-------VCGPHIASAKLTV 8742
Query: 339 VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEV 398
+ P + + + G T ++ C +P + W +NG + P+ + ++ ++
Sbjct: 8743 IEPAWERHLQDVTLKEGQTCTMTCQFS-VPNVKSEWFRNGRILKPQGRHKTEVEHKVHKL 8801
Query: 399 HISNVRYEDTGAYTC 413
I++VR ED G YTC
Sbjct: 8802 TIADVRAEDQGQYTC 8816
Score = 37.0 bits (84), Expect = 0.077
Identities = 24/95 (25%), Positives = 41/95 (43%), Gaps = 1/95 (1%)
Query: 339 VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEV 398
+PP I + PE + G + H G P P W K ++ + + S +
Sbjct: 18898 LPPKI-LMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSIL 18956
Query: 399 HISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDS 433
I +V +D+G Y+ A+N +G D + V D+
Sbjct: 18957 IIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA 18991
Score = 36.2 bits (82), Expect = 0.13
Identities = 18/66 (27%), Positives = 29/66 (43%)
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
G + G P P + W K+GI+I + ++ N + + + + DTG Y
Sbjct: 25804 GEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLT 25863
Query: 415 AKNEAG 420
KN AG
Sbjct: 25864 LKNVAG 25869
Score = 36.2 bits (82), Expect = 0.13
Identities = 19/63 (30%), Positives = 28/63 (44%)
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
G L +G PKP + WLK+G+ + + + N + I N + E G YT I
Sbjct: 27578 GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYTVI 27637
Query: 415 AKN 417
N
Sbjct: 27638 LDN 27640
Score = 35.8 bits (81), Expect = 0.17
Identities = 33/172 (19%), Positives = 76/172 (44%), Gaps = 15/172 (8%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G++A C + + ++W +N+ L+ I+ G L + +VT +
Sbjct: 11588 GETATFVCELSHE-KMHVVWFKNDAKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQ 11646
Query: 323 ADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCH-AEGIPKPQLGWLKNGIDI 381
Q + + + ++++ ++ + +T L+C ++ +P + W K+G +I
Sbjct: 11647 VKELSSTAQLKVLEADPYFTVKLHDKTAVEKDEIT--LKCEVSKDVP---VKWFKDGEEI 11701
Query: 382 TPKLSKQLTLQANGSE--VHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE 431
P S + +++A+G + I +D G Y C + G D+ +++ VE
Sbjct: 11702 VP--SPKYSIKADGLRRILKIKKADLKDKGEYVC----DCGTDKTKANVTVE 11747
Score = 35.4 bits (80), Expect = 0.22
Identities = 20/55 (36%), Positives = 24/55 (43%)
Query: 366 GIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
G P P+ W K G DI P Q+T S + I +D G YT A N G
Sbjct: 20405 GKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNPFG 20459
Score = 35.4 bits (80), Expect = 0.22
Identities = 25/117 (21%), Positives = 47/117 (40%), Gaps = 2/117 (1%)
Query: 304 GSLYITKVTTTHVGNYTCYADGYEQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCH 363
G Y +V +V + Y++ ++ ++ + ++ G + L
Sbjct: 29410 GQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELADDLKKTVTIRAGASLRLMVS 29469
Query: 364 AEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
G P P + W K GID+ + T + S + + V D G YT A+N++G
Sbjct: 29470 VSGRPPPVITWSKQGIDLASRAIIDTT--ESYSLLIVDKVNRYDAGKYTIEAENQSG 29524
Score = 35.0 bits (79), Expect = 0.29
Identities = 22/86 (25%), Positives = 38/86 (44%), Gaps = 2/86 (2%)
Query: 339 VPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANG--S 396
+PP I P + + G ++ C G P P++ W G I + + ++ +
Sbjct: 33327 IPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLT 33386
Query: 397 EVHISNVRYEDTGAYTCIAKNEAGVD 422
+ I +V+ +D G YT NE G D
Sbjct: 33387 TLIIMDVQKQDGGLYTLSLGNEFGSD 33412
Score = 34.7 bits (78), Expect = 0.38
Identities = 46/188 (24%), Positives = 71/188 (37%), Gaps = 9/188 (4%)
Query: 262 VGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTC 321
+G++A LSC I G P I W R L ++ G +L + G YTC
Sbjct: 30546 LGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTC 30605
Query: 322 YADGY--EQVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAE--GIPKPQLGWLKN 377
A E + + P YP + V ++LR H G P P + W +
Sbjct: 30606 IATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWF-H 30664
Query: 378 GIDITPKLSKQLTLQANGSEVHI--SNV-RYEDTGAYTCIAKNEAGVDEDISSLFVEDSA 434
G + S+ +T++ H+ NV R G Y N G + I + ++D
Sbjct: 30665 GQKLLQN-SENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKP 30723
Query: 435 RKTLANIL 442
K I+
Sbjct: 30724 DKPTGPIV 30731
Score = 34.3 bits (77), Expect = 0.50
Identities = 19/68 (27%), Positives = 31/68 (45%), Gaps = 2/68 (2%)
Query: 355 GVTASLRCHAEGIPKPQLGWLKN--GIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYT 412
G T L G P P++ W K+ D+T ++ +A+ S+ ++ + D G Y
Sbjct: 18216 GDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGGKYV 18275
Query: 413 CIAKNEAG 420
A N AG
Sbjct: 18276 VTATNTAG 18283
Score = 33.5 bits (75), Expect = 0.85
Identities = 24/90 (26%), Positives = 41/90 (45%), Gaps = 5/90 (5%)
Query: 337 VNVPPVIRVYPESQAREPGVTASLRCHAEG--IPKPQLGWLKNGIDITPKLSKQLTLQAN 394
V+ PP I + +++A + A L C E + ++ W K+G + Q A+
Sbjct: 32714 VSAPPKITQFLKAEASKE--IAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSAD 32771
Query: 395 GS-EVHISNVRYEDTGAYTCIAKNEAGVDE 423
G+ E+ I+N+ D G Y C E G +
Sbjct: 32772 GTYELKINNLTESDQGEYVCEISGEGGTSK 32801
Score = 33.1 bits (74), Expect = 1.1
Identities = 35/167 (20%), Positives = 63/167 (37%), Gaps = 6/167 (3%)
Query: 253 QKLSITAATVGQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVT 312
+ L T AV SC + + + W RN + F DGS++ +
Sbjct: 12827 EHLEDQTVTEFDDAVFSCQLSRE-KANVKWYRNG---REIKEGKKYKFEKDGSIHRLIIK 12882
Query: 313 TTHVGNYTCYADGYE-QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQ 371
+ + YA G E + + +F +P I P+ PG K +
Sbjct: 12883 DCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNK-DKVE 12941
Query: 372 LGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNE 418
+ WL+N + + Q+ + + I +++ D G Y IAK++
Sbjct: 12942 VQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDK 12988
Score = 33.1 bits (74), Expect = 1.1
Identities = 47/233 (20%), Positives = 78/233 (33%), Gaps = 30/233 (12%)
Query: 340 PPVIRV-YPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEV 398
PP + + + + G +L G PKP++ W K+ D+ + +
Sbjct: 16817 PPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLAL 16876
Query: 399 HISNVRYEDTGAYTCIAKNEAGVDEDISSLFVE------------DSARKTLANILWR-- 444
+ D+G Y + +N G + + V D K I W+
Sbjct: 16877 EKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRPGPPVGPVSFDEVTKDYMVISWKPP 16936
Query: 445 --EEGLGIGNMFYVFYEDGIKVIQPIECEFQRHIKPSEKLLGFQDEVCPKAEG-DEVQRC 501
+ G I N E G V P+ + KLL EG D + R
Sbjct: 16937 LDDGGSKITNYIIEKKEVGKDVWMPVTSASAKTTCKVSKLL----------EGKDYIFRI 16986
Query: 502 VWASAVNVKDKFIYVAQPTLDRVLIVDVQSQKVVQAVSTDPVPVKLHYDKSHD 554
+ + D + + DR + D Q +V V+ D V ++K HD
Sbjct: 16987 HAENLYGISDPLVSDSMKAKDRFRVPDAPDQPIVTEVTKDSALVT--WNKPHD 17037
Score = 32.7 bits (73), Expect = 1.5
Identities = 15/59 (25%), Positives = 27/59 (45%)
Query: 374 WLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
W+K+G +I + ++HI +V+ D G YTC+ + + L VE+
Sbjct: 11151 WMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEE 11209
Score = 32.7 bits (73), Expect = 1.5
Identities = 17/69 (24%), Positives = 29/69 (42%)
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
GVT L +G P P++ W K +++ ++ + + + NV D G Y
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILT 19767
Query: 415 AKNEAGVDE 423
+N G E
Sbjct: 19768 LENSCGKKE 19776
Score = 32.3 bits (72), Expect = 1.9
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 17/81 (20%)
Query: 349 SQAREPGVTASLRCHAEGIPKPQLGW---------LKNGIDITPKLSKQLTLQANGSEVH 399
SQ R P V +G P P+ W +K+G+ P+ QL N S +
Sbjct: 15826 SQIRIPAVI-------KGRPTPKSSWEFDGKAKKAMKDGVHDIPE-DAQLETAENSSVII 15877
Query: 400 ISNVRYEDTGAYTCIAKNEAG 420
I + TG Y+ AKN+AG
Sbjct: 15878 IPECKRSHTGKYSITAKNKAG 15898
Score = 32.3 bits (72), Expect = 1.9
Identities = 22/95 (23%), Positives = 41/95 (43%), Gaps = 3/95 (3%)
Query: 341 PVIRV---YPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE 397
P I+V + ++ + G L G P P + W K+G ++ ++ + +
Sbjct: 21459 PKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTN 21518
Query: 398 VHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVED 432
+ + D+GAYT A N G + I ++ V D
Sbjct: 21519 LVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLD 21553
Score = 32.0 bits (71), Expect = 2.5
Identities = 24/87 (27%), Positives = 35/87 (40%), Gaps = 7/87 (8%)
Query: 339 VPPVIRV---YPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQAN- 394
VPP + + E + G T G+P P W +G +I K + T++ +
Sbjct: 17506 VPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEI--KTDEHYTVETDN 17563
Query: 395 -GSEVHISNVRYEDTGAYTCIAKNEAG 420
S + I N DTG Y N AG
Sbjct: 17564 FSSVLTIKNCLRRDTGEYQITVSNAAG 17590
Score = 31.6 bits (70), Expect = 3.2
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 9/75 (12%)
Query: 360 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSE--VHISNVRYEDTGAYTCIAKN 417
L+C P + W K+G +I P SK ++A+G + + + D G YTC
Sbjct: 12037 LQCEISKADAP-VKWFKDGKEIKP--SKNAVIKADGKKRMLILKKALKSDIGQYTC---- 12089
Query: 418 EAGVDEDISSLFVED 432
+ G D+ L +ED
Sbjct: 12090 DCGTDKTSGKLDIED 12104
Score = 31.6 bits (70), Expect = 3.2
Identities = 26/92 (28%), Positives = 39/92 (42%), Gaps = 10/92 (10%)
Query: 339 VPPVIR----VYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDIT-PKLSKQLTLQA 393
VPP I+ V ++ + G + G+P P++ W KN I P + Q+T +
Sbjct: 15393 VPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSKNETVIEKPTDALQITKEE 15452
Query: 394 NG-----SEVHISNVRYEDTGAYTCIAKNEAG 420
+E+ I ED G YT A N G
Sbjct: 15453 VSRSEAKTELSIPKAVREDKGTYTVTASNRLG 15484
Score = 31.2 bits (69), Expect = 4.2
Identities = 26/87 (29%), Positives = 39/87 (44%), Gaps = 5/87 (5%)
Query: 348 ESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTL---QANGSEVHISNVR 404
+SQ G A R G P P+ W KNG+ I + S ++ + N E+ I +V
Sbjct: 2085 QSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKI--ERSDRIYWYWPEDNVCELVIRDVT 2142
Query: 405 YEDTGAYTCIAKNEAGVDEDISSLFVE 431
ED+ + A N AG + L V+
Sbjct: 2143 AEDSASIMVKAINIAGETSSHAFLLVQ 2169
Score = 31.2 bits (69), Expect = 4.2
Identities = 18/66 (27%), Positives = 26/66 (39%)
Query: 355 GVTASLRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCI 414
G T + +G P+P + W K G + + L E+ I D G Y
Sbjct: 17923 GQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIIS 17982
Query: 415 AKNEAG 420
AKN +G
Sbjct: 17983 AKNSSG 17988
Score = 30.8 bits (68), Expect = 5.5
Identities = 18/58 (31%), Positives = 28/58 (48%), Gaps = 2/58 (3%)
Query: 363 HAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEAG 420
+ G P P + W N + + + + T A S + I N + G Y+ +AKNEAG
Sbjct: 16547 YVSGKPPPTVTWNMNERTLPQEATIETT--AISSSMVIKNCQRSHQGVYSLLAKNEAG 16602
Score = 30.8 bits (68), Expect = 5.5
Identities = 22/113 (19%), Positives = 42/113 (37%)
Query: 328 QVYQTHIFQVNVPPVIRVYPESQAREPGVTASLRCHAEGIPKPQLGWLKNGIDITPKLSK 387
+V F ++ P I + S G + + P ++ W NG+++
Sbjct: 32361 EVLSQQPFTLDHAPRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKI 32420
Query: 388 QLTLQANGSEVHISNVRYEDTGAYTCIAKNEAGVDEDISSLFVEDSARKTLAN 440
T + + I + +D+G Y + N G D ++L V T A+
Sbjct: 32421 HYTNTSGVLTLEILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYAS 32473
Score = 30.4 bits (67), Expect = 7.2
Identities = 18/71 (25%), Positives = 29/71 (40%)
Query: 360 LRCHAEGIPKPQLGWLKNGIDITPKLSKQLTLQANGSEVHISNVRYEDTGAYTCIAKNEA 419
L+ +G P P + W K + + A + + + + + D G YT KN A
Sbjct: 20002 LKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVA 20061
Query: 420 GVDEDISSLFV 430
G E S+ V
Sbjct: 20062 GTKEGTISIKV 20072
Score = 30.0 bits (66), Expect = 9.4
Identities = 16/61 (26%), Positives = 27/61 (44%)
Query: 263 GQSAVLSCAIQGTLRPPIIWKRNNIILNNLDLEDINDFGDDGSLYITKVTTTHVGNYTCY 322
G+S + +QG P + W ++ + + +I D SL++ T H G YT
Sbjct: 27973 GESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTVE 28032
Query: 323 A 323
A
Sbjct: 28033 A 28033
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.137 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,843,802
Number of Sequences: 37866
Number of extensions: 1529467
Number of successful extensions: 6733
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 197
Number of HSP's successfully gapped in prelim test: 215
Number of HSP's that attempted gapping in prelim test: 3696
Number of HSP's gapped (non-prelim): 1941
length of query: 847
length of database: 18,247,518
effective HSP length: 111
effective length of query: 736
effective length of database: 14,044,392
effective search space: 10336672512
effective search space used: 10336672512
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.