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Search of human proteins with 190194412
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190194412 thyroid hormone receptor interactor 11 [Homo
sapiens]
(1979 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens] 3785 0.0
gi|169204908 PREDICTED: similar to Thyroid hormone receptor inte... 614 e-175
gi|169205597 PREDICTED: similar to Thyroid hormone receptor inte... 614 e-175
gi|169203883 PREDICTED: hypothetical protein [Homo sapiens] 614 e-175
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 234 5e-61
gi|71061468 centromere protein E [Homo sapiens] 224 6e-58
gi|21735548 centrosomal protein 2 [Homo sapiens] 219 2e-56
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 215 4e-55
gi|114155142 nuclear pore complex-associated protein TPR [Homo s... 202 2e-51
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 198 4e-50
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 197 1e-49
gi|55770834 centromere protein F [Homo sapiens] 195 4e-49
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 190 1e-47
gi|109255234 centrosomal protein 290kDa [Homo sapiens] 185 4e-46
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 181 6e-45
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 180 1e-44
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 180 1e-44
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 179 3e-44
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 179 3e-44
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 178 4e-44
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 178 4e-44
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 178 4e-44
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 178 4e-44
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 178 4e-44
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 178 4e-44
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 178 4e-44
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 178 4e-44
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 178 4e-44
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 178 4e-44
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 177 9e-44
>gi|190194412 thyroid hormone receptor interactor 11 [Homo sapiens]
Length = 1979
Score = 3785 bits (9816), Expect = 0.0
Identities = 1979/1979 (100%), Positives = 1979/1979 (100%)
Query: 1 MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAI 60
MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAI
Sbjct: 1 MSSWLGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAI 60
Query: 61 HAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQ 120
HAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQ
Sbjct: 61 HAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQ 120
Query: 121 LLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNE 180
LLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNE
Sbjct: 121 LLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNE 180
Query: 181 VSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQ 240
VSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQ
Sbjct: 181 VSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQ 240
Query: 241 NAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIE 300
NAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIE
Sbjct: 241 NAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIE 300
Query: 301 KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL 360
KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL
Sbjct: 301 KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL 360
Query: 361 QPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKL 420
QPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKL
Sbjct: 361 QPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKL 420
Query: 421 KMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKE 480
KMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKE
Sbjct: 421 KMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKE 480
Query: 481 QELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEK 540
QELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEK
Sbjct: 481 QELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEK 540
Query: 541 KRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNV 600
KRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNV
Sbjct: 541 KRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNV 600
Query: 601 SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSE 660
SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSE
Sbjct: 601 SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSE 660
Query: 661 LEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGE 720
LEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGE
Sbjct: 661 LEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGE 720
Query: 721 IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK
Sbjct: 721 IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
Query: 781 NIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
NIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK
Sbjct: 781 NIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
Query: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQ 900
NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQ
Sbjct: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQ 900
Query: 901 LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLE 960
LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLE
Sbjct: 901 LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLE 960
Query: 961 KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER 1020
KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER
Sbjct: 961 KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER 1020
Query: 1021 LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSH 1080
LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSH
Sbjct: 1021 LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSH 1080
Query: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDEN 1140
TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDEN
Sbjct: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDEN 1140
Query: 1141 KKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVN 1200
KKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVN
Sbjct: 1141 KKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVN 1200
Query: 1201 SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNN 1260
SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNN
Sbjct: 1201 SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNN 1260
Query: 1261 SKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAS 1320
SKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAS
Sbjct: 1261 SKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAS 1320
Query: 1321 LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAT 1380
LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAT
Sbjct: 1321 LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAT 1380
Query: 1381 SELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELL 1440
SELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELL
Sbjct: 1381 SELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELL 1440
Query: 1441 RQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC 1500
RQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC
Sbjct: 1441 RQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC 1500
Query: 1501 HSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMEN 1560
HSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMEN
Sbjct: 1501 HSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMEN 1560
Query: 1561 TALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL 1620
TALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL
Sbjct: 1561 TALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL 1620
Query: 1621 VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVL 1680
VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVL
Sbjct: 1621 VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVL 1680
Query: 1681 EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL 1740
EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL
Sbjct: 1681 EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL 1740
Query: 1741 DVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRH 1800
DVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRH
Sbjct: 1741 DVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRH 1800
Query: 1801 EVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSF 1860
EVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSF
Sbjct: 1801 EVLRLMGSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSF 1860
Query: 1861 SELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVN 1920
SELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVN
Sbjct: 1861 SELFVKFLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVN 1920
Query: 1921 PFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ 1979
PFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ
Sbjct: 1921 PFLAPRSAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ 1979
>gi|169204908 PREDICTED: similar to Thyroid hormone receptor
interactor 11 [Homo sapiens]
Length = 352
Score = 614 bits (1584), Expect = e-175
Identities = 315/353 (89%), Positives = 332/353 (94%), Gaps = 1/353 (0%)
Query: 1627 MENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQE 1686
MENASHQASVQVESLQEQLNVVSKQRDETAL LS SQ+QVKQYALSLANLQMVL+HFQ+E
Sbjct: 1 MENASHQASVQVESLQEQLNVVSKQRDETAL-LSASQQQVKQYALSLANLQMVLQHFQKE 59
Query: 1687 EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ 1746
EK+MYSAEL+KQKQLIAEWKK AE+LE KVISLQE LDEA+AALDSASRLTEQLD+KEEQ
Sbjct: 60 EKSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLDEADAALDSASRLTEQLDLKEEQ 119
Query: 1747 IEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLM 1806
IEELK+QNE +QEMLDDVQKKL++LANS EGKVDKVLMRNLFI HFH PKNQRHEVLRLM
Sbjct: 120 IEELKKQNEFQQEMLDDVQKKLVNLANSLEGKVDKVLMRNLFISHFHMPKNQRHEVLRLM 179
Query: 1807 GSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVK 1866
GSILGVRREEMEQLFHD+QG VTRWMTGWLG GSKSVPNTPLRPNQQSV+NSSFSE FVK
Sbjct: 180 GSILGVRREEMEQLFHDNQGSVTRWMTGWLGRGSKSVPNTPLRPNQQSVLNSSFSECFVK 239
Query: 1867 FLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVNPFLAPR 1926
FLETESH S+PPPKLSVHDMKPL+SPGRRK DTNAPESFKDTAESRSGRR +VN LAPR
Sbjct: 240 FLETESHSSVPPPKLSVHDMKPLESPGRRKLDTNAPESFKDTAESRSGRRREVNSVLAPR 299
Query: 1927 SAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ 1979
SAAVPLINPAGLGPGGP HLLLKPISDV PTFTPLP LPDNSAGVVLKDL KQ
Sbjct: 300 SAAVPLINPAGLGPGGPQHLLLKPISDVWPTFTPLPVLPDNSAGVVLKDLGKQ 352
Score = 53.1 bits (126), Expect = 3e-06
Identities = 50/202 (24%), Positives = 92/202 (45%), Gaps = 7/202 (3%)
Query: 735 EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDH--KET 792
E ++ +++ S LN + Q + L+ +Q++ + A N+ QM H KE
Sbjct: 2 ENASHQASVQVESLQEQLNVVSKQRDETALLSASQQQVKQYALSLANL-QMVLQHFQKEE 60
Query: 793 KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKD 852
K + S+ L++QKQL KK E L+ + LQE LD+ AL L + ++ K+
Sbjct: 61 KSMYSAELQKQKQLIAEWKKKA---ESLERKVISLQERLDEADAALDSASRLTEQLDLKE 117
Query: 853 RSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
+ +K++N QE L+ ++++ A + K +D V +S + K E +
Sbjct: 118 EQIEELKKQNEFQQEMLDDVQKKLVNLANSLEGK-VDKVLMRNLFISHFHMPKNQRHEVL 176
Query: 913 KHHQKIIEDQNQSKMQLLQSLQ 934
+ I+ + + QL Q
Sbjct: 177 RLMGSILGVRREEMEQLFHDNQ 198
Score = 46.2 bits (108), Expect = 3e-04
Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 16/152 (10%)
Query: 1532 VKSMQEKTVVFQQERDQ-VMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLE 1590
V+S+QE+ V ++RD+ +L+ Q+Q++ AL S L+ + H +
Sbjct: 12 VESLQEQLNVVSKQRDETALLSASQQQVKQYAL-------------SLANLQMVLQHFQK 58
Query: 1591 SEDS-YTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVS 1649
E S Y+ E + A+ +KK LE K++S ++ A A L EQL++
Sbjct: 59 EEKSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLDEAD-AALDSASRLTEQLDLKE 117
Query: 1650 KQRDETALQLSVSQEQVKQYALSLANLQMVLE 1681
+Q +E Q QE + L NL LE
Sbjct: 118 EQIEELKKQNEFQQEMLDDVQKKLVNLANSLE 149
Score = 34.3 bits (77), Expect = 1.2
Identities = 30/166 (18%), Positives = 76/166 (45%), Gaps = 21/166 (12%)
Query: 465 LDSELHDLRLNLEAKEQELNQSISEKE--TLIAEIEELDRQNQEATKHMILIKDQLSKQQ 522
+++ H + +E+ +++LN +++ L++ ++ +Q + ++ ++ K++
Sbjct: 1 MENASHQASVQVESLQEQLNVVSKQRDETALLSASQQQVKQYALSLANLQMVLQHFQKEE 60
Query: 523 NEGDSI-ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581
S + K KQ + + KK+ LE + + + LD +++ AL
Sbjct: 61 KSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLD-------EADAAL---------- 103
Query: 582 EDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNEL 627
D L +QL+ +E ++K+N +E + +++L + N L
Sbjct: 104 -DSASRLTEQLDLKEEQIEELKKQNEFQQEMLDDVQKKLVNLANSL 148
>gi|169205597 PREDICTED: similar to Thyroid hormone receptor
interactor 11 [Homo sapiens]
Length = 352
Score = 614 bits (1584), Expect = e-175
Identities = 315/353 (89%), Positives = 332/353 (94%), Gaps = 1/353 (0%)
Query: 1627 MENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQE 1686
MENASHQASVQVESLQEQLNVVSKQRDETAL LS SQ+QVKQYALSLANLQMVL+HFQ+E
Sbjct: 1 MENASHQASVQVESLQEQLNVVSKQRDETAL-LSASQQQVKQYALSLANLQMVLQHFQKE 59
Query: 1687 EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ 1746
EK+MYSAEL+KQKQLIAEWKK AE+LE KVISLQE LDEA+AALDSASRLTEQLD+KEEQ
Sbjct: 60 EKSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLDEADAALDSASRLTEQLDLKEEQ 119
Query: 1747 IEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLM 1806
IEELK+QNE +QEMLDDVQKKL++LANS EGKVDKVLMRNLFI HFH PKNQRHEVLRLM
Sbjct: 120 IEELKKQNEFQQEMLDDVQKKLVNLANSLEGKVDKVLMRNLFISHFHMPKNQRHEVLRLM 179
Query: 1807 GSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVK 1866
GSILGVRREEMEQLFHD+QG VTRWMTGWLG GSKSVPNTPLRPNQQSV+NSSFSE FVK
Sbjct: 180 GSILGVRREEMEQLFHDNQGSVTRWMTGWLGRGSKSVPNTPLRPNQQSVLNSSFSECFVK 239
Query: 1867 FLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVNPFLAPR 1926
FLETESH S+PPPKLSVHDMKPL+SPGRRK DTNAPESFKDTAESRSGRR +VN LAPR
Sbjct: 240 FLETESHSSVPPPKLSVHDMKPLESPGRRKLDTNAPESFKDTAESRSGRRREVNSVLAPR 299
Query: 1927 SAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ 1979
SAAVPLINPAGLGPGGP HLLLKPISDV PTFTPLP LPDNSAGVVLKDL KQ
Sbjct: 300 SAAVPLINPAGLGPGGPQHLLLKPISDVWPTFTPLPVLPDNSAGVVLKDLGKQ 352
Score = 53.1 bits (126), Expect = 3e-06
Identities = 50/202 (24%), Positives = 92/202 (45%), Gaps = 7/202 (3%)
Query: 735 EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDH--KET 792
E ++ +++ S LN + Q + L+ +Q++ + A N+ QM H KE
Sbjct: 2 ENASHQASVQVESLQEQLNVVSKQRDETALLSASQQQVKQYALSLANL-QMVLQHFQKEE 60
Query: 793 KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKD 852
K + S+ L++QKQL KK E L+ + LQE LD+ AL L + ++ K+
Sbjct: 61 KSMYSAELQKQKQLIAEWKKKA---ESLERKVISLQERLDEADAALDSASRLTEQLDLKE 117
Query: 853 RSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
+ +K++N QE L+ ++++ A + K +D V +S + K E +
Sbjct: 118 EQIEELKKQNEFQQEMLDDVQKKLVNLANSLEGK-VDKVLMRNLFISHFHMPKNQRHEVL 176
Query: 913 KHHQKIIEDQNQSKMQLLQSLQ 934
+ I+ + + QL Q
Sbjct: 177 RLMGSILGVRREEMEQLFHDNQ 198
Score = 46.2 bits (108), Expect = 3e-04
Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 16/152 (10%)
Query: 1532 VKSMQEKTVVFQQERDQ-VMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLE 1590
V+S+QE+ V ++RD+ +L+ Q+Q++ AL S L+ + H +
Sbjct: 12 VESLQEQLNVVSKQRDETALLSASQQQVKQYAL-------------SLANLQMVLQHFQK 58
Query: 1591 SEDS-YTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVS 1649
E S Y+ E + A+ +KK LE K++S ++ A A L EQL++
Sbjct: 59 EEKSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLDEAD-AALDSASRLTEQLDLKE 117
Query: 1650 KQRDETALQLSVSQEQVKQYALSLANLQMVLE 1681
+Q +E Q QE + L NL LE
Sbjct: 118 EQIEELKKQNEFQQEMLDDVQKKLVNLANSLE 149
Score = 34.3 bits (77), Expect = 1.2
Identities = 30/166 (18%), Positives = 76/166 (45%), Gaps = 21/166 (12%)
Query: 465 LDSELHDLRLNLEAKEQELNQSISEKE--TLIAEIEELDRQNQEATKHMILIKDQLSKQQ 522
+++ H + +E+ +++LN +++ L++ ++ +Q + ++ ++ K++
Sbjct: 1 MENASHQASVQVESLQEQLNVVSKQRDETALLSASQQQVKQYALSLANLQMVLQHFQKEE 60
Query: 523 NEGDSI-ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581
S + K KQ + + KK+ LE + + + LD +++ AL
Sbjct: 61 KSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLD-------EADAAL---------- 103
Query: 582 EDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNEL 627
D L +QL+ +E ++K+N +E + +++L + N L
Sbjct: 104 -DSASRLTEQLDLKEEQIEELKKQNEFQQEMLDDVQKKLVNLANSL 148
>gi|169203883 PREDICTED: hypothetical protein [Homo sapiens]
Length = 352
Score = 614 bits (1584), Expect = e-175
Identities = 315/353 (89%), Positives = 332/353 (94%), Gaps = 1/353 (0%)
Query: 1627 MENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQE 1686
MENASHQASVQVESLQEQLNVVSKQRDETAL LS SQ+QVKQYALSLANLQMVL+HFQ+E
Sbjct: 1 MENASHQASVQVESLQEQLNVVSKQRDETAL-LSASQQQVKQYALSLANLQMVLQHFQKE 59
Query: 1687 EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ 1746
EK+MYSAEL+KQKQLIAEWKK AE+LE KVISLQE LDEA+AALDSASRLTEQLD+KEEQ
Sbjct: 60 EKSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLDEADAALDSASRLTEQLDLKEEQ 119
Query: 1747 IEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLM 1806
IEELK+QNE +QEMLDDVQKKL++LANS EGKVDKVLMRNLFI HFH PKNQRHEVLRLM
Sbjct: 120 IEELKKQNEFQQEMLDDVQKKLVNLANSLEGKVDKVLMRNLFISHFHMPKNQRHEVLRLM 179
Query: 1807 GSILGVRREEMEQLFHDDQGGVTRWMTGWLGGGSKSVPNTPLRPNQQSVVNSSFSELFVK 1866
GSILGVRREEMEQLFHD+QG VTRWMTGWLG GSKSVPNTPLRPNQQSV+NSSFSE FVK
Sbjct: 180 GSILGVRREEMEQLFHDNQGSVTRWMTGWLGRGSKSVPNTPLRPNQQSVLNSSFSECFVK 239
Query: 1867 FLETESHPSIPPPKLSVHDMKPLDSPGRRKRDTNAPESFKDTAESRSGRRTDVNPFLAPR 1926
FLETESH S+PPPKLSVHDMKPL+SPGRRK DTNAPESFKDTAESRSGRR +VN LAPR
Sbjct: 240 FLETESHSSVPPPKLSVHDMKPLESPGRRKLDTNAPESFKDTAESRSGRRREVNSVLAPR 299
Query: 1927 SAAVPLINPAGLGPGGPGHLLLKPISDVLPTFTPLPALPDNSAGVVLKDLLKQ 1979
SAAVPLINPAGLGPGGP HLLLKPISDV PTFTPLP LPDNSAGVVLKDL KQ
Sbjct: 300 SAAVPLINPAGLGPGGPQHLLLKPISDVWPTFTPLPVLPDNSAGVVLKDLGKQ 352
Score = 53.1 bits (126), Expect = 3e-06
Identities = 50/202 (24%), Positives = 92/202 (45%), Gaps = 7/202 (3%)
Query: 735 EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDH--KET 792
E ++ +++ S LN + Q + L+ +Q++ + A N+ QM H KE
Sbjct: 2 ENASHQASVQVESLQEQLNVVSKQRDETALLSASQQQVKQYALSLANL-QMVLQHFQKEE 60
Query: 793 KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKD 852
K + S+ L++QKQL KK E L+ + LQE LD+ AL L + ++ K+
Sbjct: 61 KSMYSAELQKQKQLIAEWKKKA---ESLERKVISLQERLDEADAALDSASRLTEQLDLKE 117
Query: 853 RSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
+ +K++N QE L+ ++++ A + K +D V +S + K E +
Sbjct: 118 EQIEELKKQNEFQQEMLDDVQKKLVNLANSLEGK-VDKVLMRNLFISHFHMPKNQRHEVL 176
Query: 913 KHHQKIIEDQNQSKMQLLQSLQ 934
+ I+ + + QL Q
Sbjct: 177 RLMGSILGVRREEMEQLFHDNQ 198
Score = 46.2 bits (108), Expect = 3e-04
Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 16/152 (10%)
Query: 1532 VKSMQEKTVVFQQERDQ-VMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLE 1590
V+S+QE+ V ++RD+ +L+ Q+Q++ AL S L+ + H +
Sbjct: 12 VESLQEQLNVVSKQRDETALLSASQQQVKQYAL-------------SLANLQMVLQHFQK 58
Query: 1591 SEDS-YTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVS 1649
E S Y+ E + A+ +KK LE K++S ++ A A L EQL++
Sbjct: 59 EEKSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLDEAD-AALDSASRLTEQLDLKE 117
Query: 1650 KQRDETALQLSVSQEQVKQYALSLANLQMVLE 1681
+Q +E Q QE + L NL LE
Sbjct: 118 EQIEELKKQNEFQQEMLDDVQKKLVNLANSLE 149
Score = 34.3 bits (77), Expect = 1.2
Identities = 30/166 (18%), Positives = 76/166 (45%), Gaps = 21/166 (12%)
Query: 465 LDSELHDLRLNLEAKEQELNQSISEKE--TLIAEIEELDRQNQEATKHMILIKDQLSKQQ 522
+++ H + +E+ +++LN +++ L++ ++ +Q + ++ ++ K++
Sbjct: 1 MENASHQASVQVESLQEQLNVVSKQRDETALLSASQQQVKQYALSLANLQMVLQHFQKEE 60
Query: 523 NEGDSI-ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581
S + K KQ + + KK+ LE + + + LD +++ AL
Sbjct: 61 KSMYSAELQKQKQLIAEWKKKAESLERKVISLQERLD-------EADAAL---------- 103
Query: 582 EDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNEL 627
D L +QL+ +E ++K+N +E + +++L + N L
Sbjct: 104 -DSASRLTEQLDLKEEQIEELKKQNEFQQEMLDDVQKKLVNLANSL 148
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 234 bits (598), Expect = 5e-61
Identities = 391/1866 (20%), Positives = 794/1866 (42%), Gaps = 229/1866 (12%)
Query: 43 EEVEAELPDSRTKEIEAIHAILRSENE-RLKKLCTDLEEKHEASE---IQIKQQSTSYRN 98
+E + S+ +EIE SE E L+ + DLEEK A E +KQ + + ++
Sbjct: 1044 KEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQD 1103
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+ Q ++ + + Q +Q +L+ + A S A V T S G S H
Sbjct: 1104 KTNQIDLLQAEISENQAIIQ-KLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPEL 1162
Query: 159 DDDMDFGDIISSQQEINRLSNEVSR--------LESEVGHWRHIAQTSKAQGTDNSDQSE 210
++ I++ ++E +L ++ L+ RH+ + K Q D + E
Sbjct: 1163 EEK-----ILALEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQE 1217
Query: 211 ICKLQ-----NIIKELKQNRSQ---EID------DHQHEMSVLQNAHQQKLTEISRRHRE 256
Q NI +L+Q + Q ID D Q S + + H +
Sbjct: 1218 QFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQ 1277
Query: 257 EL------SDYEERIEELENLLQQGGSGV--IETDLSKIYEMQKTIQVLQIEKVES--TK 306
+ D+ E+ L QGG+ V I+ L +I E +K L++ S TK
Sbjct: 1278 PVLESNLCPDWPSHSEDASAL--QGGTSVAQIKAQLKEI-EAEKVELELKVSSTTSELTK 1334
Query: 307 KMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK 366
K E++ + INK+ E+ L+ + V + ++ E+ +L+ + L+
Sbjct: 1335 KSEEVFQLQEQINKQGLEIES----LKTVSHEAEVHAESLQQKLESSQLQIAGLEHLREL 1390
Query: 367 QSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLK-LKMRIE 425
Q + E ++++++ E+V L LS+ E L+ + + ED +K L ++E
Sbjct: 1391 QPK-LDELQKLISKKE--EDVSYLSGQLSEKE---AALTKIQTEIIEQEDLIKALHTQLE 1444
Query: 426 VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQ 485
+ KE + ++LQ+ L ++ + E I + ++ L+A +
Sbjct: 1445 MQAKEHD---ERIKQLQVELCEMKQKPEEIGEESRAK-------QQIQRKLQAALISRKE 1494
Query: 486 SISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQ 545
++ E ++L E+ + TK + ++ Q+S Q E D+++ +L + K + +
Sbjct: 1495 ALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITE 1554
Query: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL----VDQLNKSQESNVS 601
++ ++ + L E L ++AL L K+KL ++E+L + + + QE +
Sbjct: 1555 MDRSLLE-NQSLSSSCESL---KLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKE 1610
Query: 602 IQKENLELKEHIRQNEEELSRIRN--ELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLS 659
+QKE L + E RI++ E ++ Q+ + T ++E E + L++
Sbjct: 1611 LQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETE-KQLQEAEQ 1669
Query: 660 ELEQLNENLKKVAFDVKMENEKLV-LACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEK 718
E+E++ E ++K A K + +K++ L E+ R + E AG+ +ETL
Sbjct: 1670 EMEEMKEKMRKFA---KSKQQKILELEEENDRLRAEVHPAGDTA-----KECMETLLSSN 1721
Query: 719 GEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAEL 778
++ EL +R+ E K + L + ++ + +Q + +H I+ N K +
Sbjct: 1722 ASMKEEL----ERVKMEYETLSKKFQSLMSEKDSLSEEVQ-DLKHQIEGNVSKQANLEAT 1776
Query: 779 KKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQAL 838
+K+ Q + + T+ + + EEQ L+ ++ + E + S +S
Sbjct: 1777 EKHDNQTNVTEEGTQSIPGET-EEQDSLS--MSTRPTCSESVPSAKSANPAVSKDFSSHD 1833
Query: 839 RKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEV 898
N L+Q + K+R G ++EE +E + L E++ K + L EV
Sbjct: 1834 EINNYLQQIDQLKERIAG-LEEEKQKNKEFSQTLENEKNTLLSQISTKD-GELKMLQEEV 1891
Query: 899 SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLF 958
+++N + + ++EE+ K+ E + K L + L Q E++ + Q + T Q+
Sbjct: 1892 TKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQ-DVTDAQI- 1949
Query: 959 LEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAET 1018
K+E ++S K +++ ++L EE+Q + + + + E + + L G++K +K+
Sbjct: 1950 --KNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHA 2007
Query: 1019 ERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD-EVGKLTQIIQQKDLEI------QAL 1071
+ L + +KE++ E+K L + I ++I L + + + Q QKDLEI QA+
Sbjct: 2008 KELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAV 2067
Query: 1072 HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSH-LKTEY-HKMMDIVAAK 1129
R + + L Q+ A L ++ + N +K++ K D+
Sbjct: 2068 EHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRL 2127
Query: 1130 EAALIKLQDENKKLSTRFESSGQDM--FRETIQNLSRIIREKDIEIDALSQKCQTLLAVL 1187
E A K E K + + ++ ++ ETI + + +KD E+ L + + + L
Sbjct: 2128 EQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQL 2187
Query: 1188 QTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELH 1247
+ L +RD++ + KK W+++ +Q+ + E ++
Sbjct: 2188 ----------AAFTKSMSSLQDDRDRVIDEAKK---WERKFSDAIQSKEEEIRLKEDNCS 2234
Query: 1248 QLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLG 1307
L+ Q+ S + +L+++ + L + E+K Q Q+Q + C+T L G
Sbjct: 2235 VLKDQLRQMSIHMEELKINISRLEHDKQIWESK----AQTEVQLQQKV---CDT---LQG 2284
Query: 1308 KLDIISPQLSSASLLTPQSAECLRASKSEV---------LSESSELLQQELEELRKSLQE 1358
+ + QL L S L +SE+ LS S E +++ L +++
Sbjct: 2285 ENKELLSQLEETRHLYHSSQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQ 2344
Query: 1359 KDATIRTLQENNHRLSDSIAATSELERKEHEQTDSE----IKQLKEKQDVLQKLLKE--- 1411
++A I+ + + +L + A+ EL + HE+ + + I L K++ +Q + E
Sbjct: 2345 QEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQ 2404
Query: 1412 ---------KDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL------ILEM 1456
++LL + + + ++ EN N+L+ T KE I
Sbjct: 2405 QHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQLDSFVK 2464
Query: 1457 DIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKE 1516
+ L+ + ++IV +YQ L+E ++ ++ EK+ + ++A A LKE
Sbjct: 2465 SMSSLQNDRDRIV-------GDYQQLEERHLS---IILEKD----QLIQEAAAENNKLKE 2510
Query: 1517 KEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA--LKQKQM------ENTALQNEVQ 1568
+ +G ++ L + + + + ++++ +QV+ +QKQ+ +N L+N+
Sbjct: 2511 EIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYA 2570
Query: 1569 RLRDK---EFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEK-----L 1620
+L +K +N++L R N L E + ++E + + ++L ++VT L+E+
Sbjct: 2571 KLEEKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLY 2630
Query: 1621 VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVL 1680
+ E H+ S S Q+++ + ++ + V +E K+ L+ L
Sbjct: 2631 HAQLKVKEEEVHRLSALFSSSQKRIAELEEE------LVCVQKEAAKKVGEIEDKLKKEL 2684
Query: 1681 EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVI---------------------SL 1719
+H + M + E E ++ +AE ++ +E K++ SL
Sbjct: 2685 KHLHHDAGIMRN-ETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSL 2743
Query: 1720 QECLDEANAALDSASRLTEQLDVKEEQIEELKRQ---NELRQEMLDDVQKKLMSLANSSE 1776
Q D AN LD R + D +++ +LK Q N R +L + + S +S
Sbjct: 2744 QNSRDHANEELDELKR---KYDASLKELAQLKEQGLLNRERDALLSETAFSMNSTEENSL 2800
Query: 1777 GKVDKV 1782
++K+
Sbjct: 2801 SHLEKL 2806
Score = 220 bits (560), Expect = 1e-56
Identities = 402/1935 (20%), Positives = 787/1935 (40%), Gaps = 311/1935 (16%)
Query: 18 QVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRT-KEIEAIHAILRSENERLKKLCT 76
Q G + A L + S + E E+ L +T +E+++ L+ +N +L
Sbjct: 351 QAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKL----- 405
Query: 77 DLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAG 136
L++K+E + +Q Q +QLQQK EIS R + LQ Q++ V + G
Sbjct: 406 -LQDKNEQA-VQSAQTIQQLEDQLQQKSKEISQFLNR-LPLQQHETASQTSFPDVYN-EG 461
Query: 137 VPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQ 196
A T + I+ + + + G ++ S E+ L E +L S++ + +
Sbjct: 462 TQAVTEEN-----IASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT----LLE 512
Query: 197 TSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEIS----- 251
G + + SEI I ++ RS ++ + VL+N QK E+S
Sbjct: 513 AQNRTGEADREVSEIS-----IVDIANKRSSSAEESGQD--VLENTFSQKHKELSVLLLE 565
Query: 252 -RRHREELSDYE-----ERIEELEN-------LLQQGGSGVIETDLSKIYE--------- 289
+ +EE++ + +R EE ++ + Q G G+ + E
Sbjct: 566 MKEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLM 625
Query: 290 --MQKTIQVLQIEKVESTKKMEQLED-KIKDINKKLSSAENDRD--------ILRREQEQ 338
+ ++ ++ E+ + + E+ + D +L S + D D I + Q++
Sbjct: 626 PNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDE 685
Query: 339 LNVEKRQIME---------------------ECENLKLECSKLQPSAVKQSDTMT----E 373
L K QI+E E NL + + +A S T E
Sbjct: 686 LERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEE 745
Query: 374 KERILAQSASVEEVFRLQQALSDAEN---EIMRLSSLNQDNSLAEDNLKLK--------- 421
++++L+Q + V L+ + E E R L+ ++ A DNL +
Sbjct: 746 RDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLTEQIHSLSIEA 805
Query: 422 ----MRIEVLEKEKS---LLSQEKEELQMSLL-KLNNEYEVIKSTATRDISLDSELHDLR 473
++IEVL+ E L E+ L SL +L N+ + A R + S++ +L
Sbjct: 806 KSKDVKIEVLQNELDDVQLQFSEQSTLIRSLQSQLQNKESEVLEGAERVRHISSKVEELS 865
Query: 474 LNLEAKEQEL---NQSISEK----ETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGD 526
L KE E+ +Q + EK ETL IEE D+Q E + M QL++++
Sbjct: 866 QALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLNEEKFSLG 925
Query: 527 SIISKLKQDLN----DEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLE 582
I LK+ LN E+ + Q+E+D +++ L +++ + ++K++L+
Sbjct: 926 VEIKTLKEQLNLLSRAEEAKKEQVEEDN-EVSSGLKQNYDEMSPAG------QISKEELQ 978
Query: 583 DKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDT 642
+ + L + + + + EL + + + EEEL+ +++E + +
Sbjct: 979 HEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEI----------P 1028
Query: 643 LLKEREAEVRNLKQNLSELEQ-LNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNN 701
L + EV K+N E+ + +++ +K + + + +R LEE LA
Sbjct: 1029 LSETERGEVEEDKENKEYSEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEKLAAEE 1088
Query: 702 QLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEH 761
Q + +TL+ + +I+ + + E +K I ++A + ++ AL E
Sbjct: 1089 QFQALVKQMNQTLQDKTNQIDL----LQAEISENQAIIQKLITSNTDASDGDSVALVKE- 1143
Query: 762 EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLK 821
+ ++ K +E+ ++ K+ L QK+L + + ++ ++K +
Sbjct: 1144 --TVVISPPCTGSSEHWKPELEEKILALEKEKEQL------QKKLQEALTSRKAILKKAQ 1195
Query: 822 ERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL----REEQS 877
E+ L+EEL + + L++ +E+ + EN ++ ++L +L RE
Sbjct: 1196 EKERHLREELKQQKDDYNR---LQEQFDEQSK-------ENENIGDQLRQLQIQVRESID 1245
Query: 878 RTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQ------ 931
P D + S T E T + H + ++ + + LQ
Sbjct: 1246 GKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVA 1305
Query: 932 SLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNS 991
++ Q KE++ + + E ++ T +K EE+ LQ EQI Q E + ++T
Sbjct: 1306 QIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQ---EQINKQ-GLEIESLKT--- 1358
Query: 992 DIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSK 1051
+ E +V + +++ E L A E L + + + KL+++K ++ QLS+
Sbjct: 1359 -VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKKEEDVSYLSGQLSE 1417
Query: 1052 DEVGKL---TQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEK 1108
E T+II+Q+DL I+ALH ++ + D Q Q++ M+++ E+
Sbjct: 1418 KEAALTKIQTEIIEQEDL-IKALHTQLEMQAKEHDERIKQLQVELCEMKQKP------EE 1470
Query: 1109 TRENSHLKTEYHKMMD--IVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRII 1166
E S K + + + +++ KEA ENK L + R TI+ L++ +
Sbjct: 1471 IGEESRAKQQIQRKLQAALISRKEAL-----KENKSLQEEL-----SLARGTIERLTKSL 1520
Query: 1167 REKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQ 1226
+ + ++ A +++ T+L L + + ++L+ E D+ + + + +
Sbjct: 1521 ADVESQVSAQNKEKDTVLGRL----------ALLQEERDKLITEMDRSLLENQSLSSSCE 1570
Query: 1227 QVMTTVQNMQHESAQLQEELHQLQAQVLVDS----DNNSKLQVDYTGLIQSYEQNETKLK 1282
+ ++ + + +L +E+ L++ + +S + + +LQ +Y L+QSYE
Sbjct: 1571 SLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYE------- 1623
Query: 1283 NFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
N E ++QH + + K L GKL +S E + + L E+
Sbjct: 1624 NVSNEAERIQHVVEAVRQEKQELYGKL---------------RSTEANKKETEKQLQEAE 1668
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRL--------------SDSIAATSELERKEH 1388
+ +++ E++RK + K I L+E N RL +++ +++ ++E
Sbjct: 1669 QEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEEL 1728
Query: 1389 EQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSD------------QLLSSNENFTNKVNE 1436
E+ E + L +K Q L+ EKD L + D L + E N+ N
Sbjct: 1729 ERVKMEYETLSKK---FQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDNQTNV 1785
Query: 1437 NELLRQAVTNLKERILILEM--------DIGKLKGENEKIVETYRGKETEYQALQETNMK 1488
E Q++ E L M + K N + + + + LQ+ +
Sbjct: 1786 TEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQID-- 1843
Query: 1489 FSMMLREKEFECHSMKEKALAFEQLLKEKE-------QGKTGELNQLLNAVKSMQEKTVV 1541
L+E+ K+K F Q L+ ++ K GEL L V M
Sbjct: 1844 ---QLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQ 1900
Query: 1542 FQQERDQVM----LALKQKQMENTALQNEVQRLRDKEFRSNQEL--ERLRNHLLESEDSY 1595
Q+E +V A ++K L N++ L Q++ +++N LLESE
Sbjct: 1901 IQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQIKNELLESEMKN 1960
Query: 1596 TREALA-AEDREAKLRKKVTVLE--------EKLVSSSNAMENASHQASVQVESLQEQLN 1646
++ ++ E+ + +L K+ T +E EK+ + N SH +Q ++Q
Sbjct: 1961 LKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNKSHAKELQELLKEKQQE 2020
Query: 1647 VVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWK 1706
V Q+D Q +S +L LE Q E + E Q + K
Sbjct: 2021 VKQLQKDCIRYQEKIS---------ALERTVKALEFVQTESQKDLEITKENLAQAVEHRK 2071
Query: 1707 KNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIE-ELKRQNELRQEMLDDVQ 1765
K L + L + EA L +L ++L +E ++ ++K+++E + L+ +
Sbjct: 2072 KAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAE 2131
Query: 1766 KKLMSLANSSEGKVD 1780
+K + + + K+D
Sbjct: 2132 EKHLKEKKNMQEKLD 2146
Score = 204 bits (520), Expect = 5e-52
Identities = 378/1842 (20%), Positives = 776/1842 (42%), Gaps = 244/1842 (13%)
Query: 55 KEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQ 114
KE E + L+ K + +EK ++KQQ Y N+LQ++ E S
Sbjct: 1171 KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDY-NRLQEQFDEQSKENEN- 1228
Query: 115 IALQDQLLKLQSAAQSVPSGAGVPATTASSS-----------FAYGISHHPSAFHDDDMD 163
+ DQL +LQ + G +P+T S F HH + ++
Sbjct: 1229 --IGDQLRQLQIQVRESIDGK-LPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNL- 1284
Query: 164 FGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQ 223
D S ++ + L S + + A+ + + +S SE+ K + +L++
Sbjct: 1285 CPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQE 1344
Query: 224 NRSQE------IDDHQHEMSVLQNAHQQKL--TEISRRHREELSDYEERIEELENLLQQG 275
+++ + HE V + QQKL +++ E L + + +++EL+ L+ +
Sbjct: 1345 QINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLISKK 1404
Query: 276 GSGV----------------IETDLSKIYEMQKTIQV-LQIEKVESTKKMEQLEDKIKDI 318
V I+T++ + ++ K + L+++ E ++++QL+ ++ ++
Sbjct: 1405 EEDVSYLSGQLSEKEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEM 1464
Query: 319 NKK---LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+K + + ++R+ + + +++ ++E ++L+ E S + + + + ++ + E
Sbjct: 1465 KQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVE 1524
Query: 376 -RILAQSASVEEVFRLQQALSDAENEIMRLS--SLNQDNSLAEDNLKLKMRIEVLEKEKS 432
++ AQ+ + V L + ++++ SL ++ SL+ LK+ +E L ++K
Sbjct: 1525 SQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGLTEDKE 1584
Query: 433 LLSQEKEELQMSLL-----------KLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQ 481
L +E E L+ S + +L EYE++ + ++ +E ++ +EA Q
Sbjct: 1585 KLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYE---NVSNEAERIQHVVEAVRQ 1641
Query: 482 ELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKK 541
E + + + A +E ++Q QEA + M +K+++ K I +L+++ + +
Sbjct: 1642 EKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRA 1701
Query: 542 RVHQLEDDKMDITKEL----DVQKEKLIQSEVALNDLHLTKQKL---EDKVENLVDQLNK 594
VH D + + L KE+L + ++ L Q L +D + V L
Sbjct: 1702 EVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKH 1761
Query: 595 SQESNVSIQKENLELKEHIRQN---EEELSRIRNELMQ--SLNQDSNSNFKDTLLKEREA 649
E NVS Q ++H Q EE I E + SL+ + +++ + A
Sbjct: 1762 QIEGNVSKQANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSA 1821
Query: 650 ------------EVRNLKQNLSELEQL-----NENLKKVAFDVKMENEKLVLACED---- 688
E+ N Q + +L++ E K F +ENEK L +
Sbjct: 1822 NPAVSKDFSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKD 1881
Query: 689 -----VRHQLEECLAGNNQLSLEKNTIV---ETLKMEKGEIEAELCWAKKRLLEEANKYE 740
++ ++ + N Q+ E + + ET + EK ++E L L Y
Sbjct: 1882 GELKMLQEEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYC 1941
Query: 741 KTIEEL--------SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKET 792
+ + + S +NL +LE E + +K +E K+ +E++ KE
Sbjct: 1942 QDVTDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEP 2001
Query: 793 KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKD 852
+ K+L +L+ +K+ +++L++ + QE++ + ++ E + QT +KD
Sbjct: 2002 -----GNKSHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFV-QTESQKD 2055
Query: 853 RSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
+ +L + +E ++ Q A +A K L T+ SE +++ L++E+
Sbjct: 2056 LEI-----TKENLAQAVEHRKKAQ---AELASFKVLLDDTQ--SEAARVLADNLKLKKEL 2105
Query: 913 KHHQKIIEDQNQSKMQLLQSLQEQ--KKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQK 970
+ +++ ++ Q + K + L+ EQ +K + E + E+++A + + +E I +Q
Sbjct: 2106 QSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREK-VHLEETIGEIQV 2164
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
T+ + ++ + ++++ + + + TK S ++ D +K + I+ +E
Sbjct: 2165 TLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDEAKKWERKFSDAIQSKEE 2224
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQAL-HARISSTSHTQDVVYLQQ 1089
EI+L E N S+ K D++ +++ +++ + I L H + S Q V LQQ
Sbjct: 2225 EIRL-KEDNCSVLK-------DQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQ 2276
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
++ K E+TR HL YH + +A E+ L L+D+ LS E
Sbjct: 2277 KVCDTLQGENKELLSQLEETR---HL---YHSSQNELAKLESELKSLKDQLTDLSNSLEK 2330
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+E NL IIR+++ +I + L LQ S + S EE+
Sbjct: 2331 C-----KEQKGNLEGIIRQQEADIQNSKFSYEQLETDLQASRE------LTSRLHEEINM 2379
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTV-QNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYT 1268
+ K+ + EE Q + + Q E +L+ L Q + + +V + N K VD T
Sbjct: 2380 KEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKA-VDKT 2438
Query: 1269 GLIQSYEQNETKLKNFGQELAQVQH---SIGQLCNTKDLLLGKLDIISPQ-----LSSAS 1320
Q E +T K Q+ AQ+ S+ L N +D ++G + + L
Sbjct: 2439 N--QLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQ 2496
Query: 1321 LLTPQSAEC---------LRASKSEVLSESSEL---LQQELEELRKSLQEKDATIRTLQE 1368
L+ +AE LR+ ++ SE+++L L Q E+L + + KD+ + L E
Sbjct: 2497 LIQEAAAENNKLKEEIRGLRSHMDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLE 2556
Query: 1369 ----NNHRLSDSIAATSELERKEHEQTDSEIKQ----LKEKQDVLQKLLKEKDLLIKAKS 1420
N L + A E + KE E+ + ++++ L+E++ L K ++ + I +
Sbjct: 2557 VQLQQNKELENKYAKLEE-KLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLT 2615
Query: 1421 DQLLSSNENFTN-------KVNENELLR---------QAVTNLKERILILEMDIGKLKGE 1464
Q+ + E T KV E E+ R + + L+E ++ ++ + K GE
Sbjct: 2616 RQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEELVCVQKEAAKKVGE 2675
Query: 1465 NE-KIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTG 1523
E K+ + + + ++ + E + M++K L ++ ++ +G T
Sbjct: 2676 IEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLL----MVTKENKGLTA 2731
Query: 1524 ELNQLLNAVKSMQEKTVVFQQERDQV----------MLALKQKQM---ENTALQNEVQ-R 1569
++ ++ S+Q +E D++ + LK++ + E AL +E
Sbjct: 2732 QIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNRERDALLSETAFS 2791
Query: 1570 LRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLR---KKVTVLE--------- 1617
+ E S LE+L LL ++ + ED +++ K + L+
Sbjct: 2792 MNSTEENSLSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQSFSKAMASLQNERDHLWNE 2851
Query: 1618 -EKLVSSSNAMENASHQASV---QVESLQEQLNVVSKQRDETALQLSVSQE---QVKQYA 1670
EK S + ++ Q S +V+SL++ ++ + RD +L Q+ Q+ Q
Sbjct: 2852 LEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRLLKELKNLQQQYLQINQEI 2911
Query: 1671 LSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENL 1712
L L+ L+ +Q + KA + E+ +Q W+ L
Sbjct: 2912 TELHPLKAQLQEYQDKTKA-FQIMQEELRQENLSWQHELHQL 2952
Score = 202 bits (513), Expect = 3e-51
Identities = 384/1915 (20%), Positives = 786/1915 (41%), Gaps = 295/1915 (15%)
Query: 72 KKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSV 131
++L +L++ ++Q++Q+ + + + + + +I LK A +L L + +
Sbjct: 58 EQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA---KLTSLNKYIEEM 114
Query: 132 PSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHW 191
+ G T S +S H + +++M+ I QE L +S L+
Sbjct: 115 KAQGGTVLPTEPQSEEQ-LSKHDKSSTEEEMEIEKIKHKLQEKEEL---ISTLQ------ 164
Query: 192 RHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQ--NAHQQKLTE 249
AQ ++AQ + S + ++K+ Q + + I Q ++S Q A QQ + E
Sbjct: 165 ---AQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVRE 221
Query: 250 ISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKME 309
R ++ +E+ + +L V + D+ EMQ+ ++VLQ + E + +
Sbjct: 222 KDARFETQVRLHEDELLQL----------VTQADVET--EMQQKLRVLQRKLEEHEESLV 269
Query: 310 QLEDKIKDINKKLSSAENDRDILRREQEQLNVE----KRQIMEECENLKLECSKLQPSAV 365
+ + ++L++AE IL ++ +Q+ E + + E E K+ K++
Sbjct: 270 GRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVA 329
Query: 366 KQS----DTMTEKERILAQ-------SASVEEVFRLQQALSDAENE-----IMRLSSLNQ 409
++ + E +L Q A +E + + AE E I+ L Q
Sbjct: 330 ERKLSFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQ 389
Query: 410 D-----NSLAEDNLKL--------KMRIEVLEKEKSLLSQEKEELQMSLLKLN-NEYEVI 455
+ ++L + N KL + +++ + L Q+ +E+ L +L ++E
Sbjct: 390 ELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETA 449
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLI---AEIEELDRQNQEATKHMI 512
T+ D+ + N+ + ++ + + +EK L+ E+EEL +N++ + +
Sbjct: 450 SQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQIT 509
Query: 513 LIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLI------- 565
L++ Q + E D +S++ ++ KR E+ D+ + QK K +
Sbjct: 510 LLEAQ--NRTGEADREVSEI-SIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEM 566
Query: 566 ---QSEVALNDLHLTKQKLEDKVENLVDQ----------------------------LNK 594
Q E+A L L ++ E+ ++DQ L
Sbjct: 567 KEAQEEIAFLKLQLQGKRAEEADHEVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFPLMP 626
Query: 595 SQESNV-SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFK--DTLLKEREAEV 651
++ES++ +++KE + R +EE ++S QD + + + + + E+
Sbjct: 627 NEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQDEL 686
Query: 652 RNLKQNLSELE----QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK 707
LK + ELE + E +K + E L E+ + + + LS E+
Sbjct: 687 ERLKSQILELELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADNNSSAFTALSEER 746
Query: 708 NTIVETLK--MEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLI 765
+ ++ +K E+ A++ + L E + E + NL T E H +
Sbjct: 747 DQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQTAHDNLLT-----EQIHSL 801
Query: 766 KLNQK-KDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFI---EKLK 821
+ K KD++I L+ ++ + E + L SL+ Q Q NK+ + E+++
Sbjct: 802 SIEAKSKDVKIEVLQNELDDVQLQFSE-QSTLIRSLQSQLQ-----NKESEVLEGAERVR 855
Query: 822 ERSSKLQE----------ELDKYSQAL----RKNEILRQTIEEKDRSLGSMKEENNHLQE 867
SSK++E E+ K Q L R E L+QTIEEKD+ + E + + E
Sbjct: 856 HISSKVEELSQALSQKELEITKMDQLLLEKKRDVETLQQTIEEKDQ---QVTEISFSMTE 912
Query: 868 ELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKM 927
++ +L EE+ + KTL L S + KE +EE+ + + ++ ++
Sbjct: 913 KMVQLNEEKFSLG--VEIKTLKEQLNLLSRAEEAK--KEQVEEDNEVSSGLKQNYDEMSP 968
Query: 928 QLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDI- 986
S +E + E D + ++EQ + + E ++ + + E++ E +++I
Sbjct: 969 AGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQRVSRLEEELANLKDESKKEIP 1028
Query: 987 --QTDNSDIFQETKVQSLNIENGSEKHDLSKAETER--LVKGIKERELEIKLLN---EKN 1039
+T+ ++ ++ + + SEK SK + L + I E+E+E++ + E+
Sbjct: 1029 LSETERGEVEEDKENKEY-----SEKCVTSKCQEIEIYLKQTISEKEVELQHIRKDLEEK 1083
Query: 1040 ISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISS---------TSHTQ----DVVY 1086
++ +Q L K ++ Q +Q K +I L A IS TS+T D V
Sbjct: 1084 LAAEEQFQALVK----QMNQTLQDKTNQIDLLQAEISENQAIIQKLITSNTDASDGDSVA 1139
Query: 1087 LQQQLQAYAME------------REKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI 1134
L ++ + EK+ A+ EK + K+ + + +++A L
Sbjct: 1140 LVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK-------KLQEALTSRKAILK 1192
Query: 1135 KLQDENKKLSTRFESSGQDMFR---------ETIQNLSRIIREKDIEI-DALSQKCQTLL 1184
K Q++ + L + D R + +N+ +R+ I++ +++ K +
Sbjct: 1193 KAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQIQVRESIDGKLPSTD 1252
Query: 1185 AVLQTSST-GNEA---GGVNSNQFEELLQER---------------------DKLKQQVK 1219
SST G E + + +L+ ++K Q+K
Sbjct: 1253 QQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASALQGGTSVAQIKAQLK 1312
Query: 1220 KMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNET 1279
++E K ++ V + E + EE+ QLQ Q+ N L+++ + + E
Sbjct: 1313 EIEAEKVELELKVSSTTSELTKKSEEVFQLQEQI-----NKQGLEIESLKTVS--HEAEV 1365
Query: 1280 KLKNFGQELAQVQHSIGQLCNTKDLLLGKLD----IISPQLSSASLLTPQSAE---CLRA 1332
++ Q+L Q I L + ++ L KLD +IS + S L+ Q +E L
Sbjct: 1366 HAESLQQKLESSQLQIAGLEHLRE-LQPKLDELQKLISKKEEDVSYLSGQLSEKEAALTK 1424
Query: 1333 SKSEVLSESSELLQQELEELRKSLQEKDATIRTLQ-------ENNHRLSDSIAATSELER 1385
++E++ E +L++ +L +E D I+ LQ + + + A +++R
Sbjct: 1425 IQTEII-EQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQR 1483
Query: 1386 KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIK-AKSDQLLSSNENFTNKVNENELLRQAV 1444
K S + LKE + + ++L + + + KS + S + NK + L R A+
Sbjct: 1484 KLQAALISRKEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLAL 1543
Query: 1445 TNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMK 1504
+ LI EMD L EN+ + + + + L E K KE E
Sbjct: 1544 LQEERDKLITEMDRSLL--ENQSLSSSCESLKLALEGLTEDKEKL-----VKEIESLKSS 1596
Query: 1505 EKALAFEQLLKEKEQGKTGEL-----NQLLNAVKSMQEKTVVFQQERDQVMLALKQKQME 1559
+ A + E K KE K E+ + N + +Q +QE+ ++ L+ +
Sbjct: 1597 KIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEAN 1656
Query: 1560 NTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKV-----T 1614
+ ++Q + QE+E ++ + + S ++ L E+ +LR +V T
Sbjct: 1657 KKETEKQLQ-------EAEQEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDT 1709
Query: 1615 VLE--EKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALS 1672
E E L+SS+ +M+ + ++ E+L ++ + ++D + ++ + Q++
Sbjct: 1710 AKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSK 1769
Query: 1673 LANLQMVLEHFQQ-----EEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEAN 1727
ANL+ +H Q E E E+Q L + S + +
Sbjct: 1770 QANLEATEKHDNQTNVTEEGTQSIPGETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDF 1829
Query: 1728 AALDSASRLTEQLDVKEEQI---EELKRQNELRQEMLDDVQKKLMSLANSSEGKV 1779
++ D + +Q+D +E+I EE K++N+ + L++ + L+S ++ +G++
Sbjct: 1830 SSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGEL 1884
Score = 193 bits (491), Expect = 1e-48
Identities = 341/1709 (19%), Positives = 727/1709 (42%), Gaps = 259/1709 (15%)
Query: 26 LTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEE----- 80
L +I + + E TE E + KE++ + IL E + ++
Sbjct: 1586 LVKEIESLKSSKIAESTEWQE------KHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639
Query: 81 KHEASEIQIKQQSTSYRN-----QLQQKEVEISHLKARQIAL----QDQLLKLQSAAQSV 131
+ E E+ K +ST QLQ+ E E+ +K + Q ++L+L+ +
Sbjct: 1640 RQEKQELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELEEENDRL 1699
Query: 132 PSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHW 191
+ TA +S + S + + + + ++ L +E L EV
Sbjct: 1700 RAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDL 1759
Query: 192 RH-----IAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQK 246
+H +++ + + T+ D N+ +E Q+ E ++ Q +S+ +
Sbjct: 1760 KHQIEGNVSKQANLEATEKHDNQT-----NVTEEGTQSIPGETEE-QDSLSMSTRPTCSE 1813
Query: 247 LTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTK 306
++ +S +E+ N LQQ I ++++ I L+ EK ++ +
Sbjct: 1814 SVPSAKSANPAVSKDFSSHDEINNYLQQ------------IDQLKERIAGLEEEKQKNKE 1861
Query: 307 KMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVK 366
+ LE++ + ++S+ + + +L+ E ++N+ +QI EE + +KL+ +A +
Sbjct: 1862 FSQTLENEKNTLLSQISTKDGELKMLQEEVTKMNLLNQQIQEELSRV----TKLKETAEE 1917
Query: 367 QSDTMTEKERILAQSASVE-EVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLK-LKMRI 424
+ D + +ER++ Q A + + Q ++DA+ + N L E +K LK +
Sbjct: 1918 EKDDL--EERLMNQLAELNGSIGNYCQDVTDAQIK----------NELLESEMKNLKKCV 1965
Query: 425 EVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELN 484
LE+EK L +EK +++ + K EY A ++ S +L+ L+ K+QE+
Sbjct: 1966 SELEEEKQQLVKEKTKVESEIRK---EYLEKIQGAQKEPGNKSHAKELQELLKEKQQEVK 2022
Query: 485 Q----SISEKETLIA---EIEELDRQNQEATKHMILIKDQLSK---QQNEGDSIISKLKQ 534
Q I +E + A ++ L+ E+ K + + K+ L++ + + + ++ K
Sbjct: 2023 QLQKDCIRYQEKISALERTVKALEFVQTESQKDLEITKENLAQAVEHRKKAQAELASFKV 2082
Query: 535 DLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNK 594
L+D + ++ D + + KEL KE ++S++ D L +++LE E + +
Sbjct: 2083 LLDDTQSEAARVLADNLKLKKELQSNKES-VKSQMKQKDEDL-ERRLEQAEEKHLKEKKN 2140
Query: 595 SQESNVSIQKENLELKEHI-------RQNEEELSRIRNEL-------------MQSLNQD 634
QE ++++E + L+E I + ++E+ +++ L M SL D
Sbjct: 2141 MQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQQLQENLDSTVTQLAAFTKSMSSLQDD 2200
Query: 635 SNS----------NFKDTLLKEREAEVRNLKQNLS----ELEQLNENLKKVAFDV-KMEN 679
+ F D + + +E E+R + N S +L Q++ +++++ ++ ++E+
Sbjct: 2201 RDRVIDEAKKWERKFSDAI-QSKEEEIRLKEDNCSVLKDQLRQMSIHMEELKINISRLEH 2259
Query: 680 EKLVL---ACEDVRHQLEEC--LAGNNQLSL----EKNTIVETLKMEKGEIEAELCWAKK 730
+K + A +V+ Q + C L G N+ L E + + + E ++E+EL K
Sbjct: 2260 DKQIWESKAQTEVQLQQKVCDTLQGENKELLSQLEETRHLYHSSQNELAKLESELKSLKD 2319
Query: 731 RLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHK 790
+L + +N EK E+ N + ++++ +I K + EQ++TD +
Sbjct: 2320 QLTDLSNSLEKCKEQKGNLEGII---------------RQQEADIQNSKFSYEQLETDLQ 2364
Query: 791 ETKDVLSS-----SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILR 845
++++ S +++EQK ++ L K+E + E + +E+ + L + E
Sbjct: 2365 ASRELTSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEEN 2424
Query: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIK 905
+EE+++ ++ N L E L+ +++E + D + S++ L ++ ++
Sbjct: 2425 IVLEEENKKA---VDKTNQLMETLKTIKKENIQQKAQLD-SFVKSMSSLQNDRDRIVGDY 2480
Query: 906 EHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEI 965
+ LEE H II +++Q + + K+E+ R + +N+ + +L D E+
Sbjct: 2481 QQLEER---HLSIILEKDQLIQEAAAENNKLKEEIRGLRSHMDDLNSENAKL----DAEL 2533
Query: 966 KSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGI 1025
++ + Q+ T +++ + +E + + +E ++ + + + R +
Sbjct: 2534 IQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEEKLKESEEANEDLRRSFNAL 2593
Query: 1026 KEREL----EIKLLNEKNISLTKQIDQLSKD-EVGKLTQIIQQKDLEIQALHARISSTSH 1080
+E + EI+ L LT+Q+ L ++ +G ++ K+ E+ L A SS+
Sbjct: 2594 QEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQ- 2652
Query: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTR-ENSHL-----------KTEYHKMMDI--- 1125
+ + L+++L E K + +K + E HL +T ++ ++
Sbjct: 2653 -KRIAELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARD 2711
Query: 1126 VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQN--------LSRIIREKDIEIDALS 1177
+ E L+ + ENK L+ + +S G+ M ++QN L + R+ D + L+
Sbjct: 2712 LVEMEQKLLMVTKENKGLTAQIQSFGRSM--SSLQNSRDHANEELDELKRKYDASLKELA 2769
Query: 1178 Q-KCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQ 1236
Q K Q LL + + A +NS + E L +KL QQ+ +E +
Sbjct: 2770 QLKEQGLLNRERDALLSETAFSMNSTE-ENSLSHLEKLNQQLLSKDE----------QLL 2818
Query: 1237 HESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQ------ELAQ 1290
H S+QL++ +Q+Q+ + ++ + L + + E K ++ Q E+
Sbjct: 2819 HLSSQLEDSYNQVQSFSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQS 2878
Query: 1291 VQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELE 1350
++ ++ L N +D LL +L + Q L Q L K+++ QE +
Sbjct: 2879 LKKAMSSLQNDRDRLLKELKNLQQQY----LQINQEITELHPLKAQL---------QEYQ 2925
Query: 1351 ELRKSLQEKDATIR----TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQ 1406
+ K+ Q +R + Q H+L ++ ER+ EQ I ++ LQ
Sbjct: 2926 DKTKAFQIMQEELRQENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQ 2985
Query: 1407 KLLKE-----------KDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILE 1455
L++E K + S + +S + N V E ELLR + + + I E
Sbjct: 2986 NLIRELRSSSSQTQPLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKE 3045
Query: 1456 MDIGKLKGENEKIVETYRGKETEY----QALQETNMKFSMMLRE---KEFECHSMKEKAL 1508
+ I +L +++E + Q+L+E + +L E + ++ L
Sbjct: 3046 LRIQQLNSNFSQLLEEKNTLSIQLCDTSQSLRENQQHYGDLLNHCAVLEKQVQELQAGPL 3105
Query: 1509 AFE------------------QLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVM 1550
+ + L+E +Q + QL N + + E + ++ERDQ +
Sbjct: 3106 NIDVAPGAPQEKNGVHRKSDPEELREPQQSFSEAQQQLCNTRQEVNELRKLLEEERDQRV 3165
Query: 1551 LALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
A + + + +++RL E+ S++
Sbjct: 3166 AA----ENALSVAEEQIRRLEHSEWDSSR 3190
Score = 75.1 bits (183), Expect = 6e-13
Identities = 96/459 (20%), Positives = 191/459 (41%), Gaps = 57/459 (12%)
Query: 1337 VLSESSELLQQELEELRKSLQEKDATIRT-LQENNHRLSDSIAATSELERKEHEQTDSEI 1395
+LS S L L EL + D +R L H+ SD E E +
Sbjct: 1 MLSRLSGLANVVLHELSGD-DDTDQNMRAPLDPELHQESDM-----EFNNTTQEDVQERL 54
Query: 1396 KQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILE 1455
++ L+ ++++KD+ ++ K + L + NK+ + +L + K ++ L
Sbjct: 55 AYAEQLVVELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKL------HAKAKLTSLN 108
Query: 1456 MDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLK 1515
I ++K + ++ T E + K E+E E +K K E+L+
Sbjct: 109 KYIEEMKAQGGTVLPTEPQSEEQLS-------KHDKSSTEEEMEIEKIKHKLQEKEELIS 161
Query: 1516 EKEQGKT-GELNQLLNAVKSMQEKTVVFQQ--ERDQVMLALKQKQMENTALQNEVQRLRD 1572
+ T + Q + M+E ++ QQ E+++ + L+ + + A Q Q +R+
Sbjct: 162 TLQAQLTQAQAEQPAQSSTEMEEFVMMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVRE 221
Query: 1573 KEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAM----- 1627
K+ R ++ + LL+ + D E ++++K+ VL+ KL ++
Sbjct: 222 KDARFETQVRLHEDELLQ--------LVTQADVETEMQQKLRVLQRKLEEHEESLVGRAQ 273
Query: 1628 ------------ENASHQASVQVESLQEQ----LNVVSKQRDETALQLSVSQEQVKQYAL 1671
E + S Q++ ++ + N V +R+E+ + L + +V + L
Sbjct: 274 VVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRNTVETEREESKILLEKMELEVAERKL 333
Query: 1672 SLANLQMVLEHF--QQEEKAMYSAELE-KQKQLIAEWKKNAENLEGKVISLQECLDEANA 1728
S NLQ + H Q E+ AELE + L + K E ++SLQ+ E +
Sbjct: 334 SFHNLQEEMHHLLEQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQS 393
Query: 1729 ALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767
A D+ +L +++ E+ + + Q++ D +Q+K
Sbjct: 394 ACDALKDQNSKL--LQDKNEQAVQSAQTIQQLEDQLQQK 430
Score = 70.1 bits (170), Expect = 2e-11
Identities = 118/563 (20%), Positives = 226/563 (40%), Gaps = 64/563 (11%)
Query: 1231 TVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE--- 1287
T QNM+ A L ELHQ D + N+ Q D + EQ +LK+ ++
Sbjct: 22 TDQNMR---APLDPELHQES-----DMEFNNTTQEDVQERLAYAEQLVVELKDIIRQKDV 73
Query: 1288 -LAQVQHSIGQLCNTKDLLLGKLDI---------------ISPQLSSASLLTPQSAECLR 1331
L Q ++ + D + KL + + Q + PQS E L
Sbjct: 74 QLQQKDEALQEERKAADNKIKKLKLHAKAKLTSLNKYIEEMKAQGGTVLPTEPQSEEQL- 132
Query: 1332 ASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQT 1391
SK + S E+ E+E+++ LQEK+ I TLQ + A S E +E
Sbjct: 133 -SKHDKSSTEEEM---EIEKIKHKLQEKEELISTLQAQLTQAQAEQPAQSSTEMEEFVMM 188
Query: 1392 DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV--NENELLRQAV----- 1444
++++ +E LQ L + +A + + F +V +E+ELL+
Sbjct: 189 KQQLQEKEEFISTLQAQLSQTQAE-QAAQQVVREKDARFETQVRLHEDELLQLVTQADVE 247
Query: 1445 TNLKERILILEMDIGKLKGENEKIV---ETYRGKETEYQALQETNMKFSMMLREKEFECH 1501
T +++++ +L+ KL+ E +V + + E A ++ N S L++ E E +
Sbjct: 248 TEMQQKLRVLQR---KLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHN 304
Query: 1502 SMKEKALAFEQLLKEKEQGKTGELNQLLNAVK-SMQEKTVVFQQERDQVMLALKQKQMEN 1560
+++ E+E+ K LL ++ + E+ + F ++++ L+Q +
Sbjct: 305 TLRNTVET------EREESKI-----LLEKMELEVAERKLSFHNLQEEMHHLLEQFEQAG 353
Query: 1561 TALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL 1620
A R E + E+E +H+L + + A + + + K + E+
Sbjct: 354 QAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLLQDKNEQA 413
Query: 1621 VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVL 1680
V S+ ++ Q + + + + LN + Q+ ETA Q S + +
Sbjct: 414 VQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQTSFPD------VYNEGTQAVTE 467
Query: 1681 EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL 1740
E+ +K + E EK L++ + E + +S Q L EA A R ++
Sbjct: 468 ENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLLEAQNRTGEADREVSEI 527
Query: 1741 DVKEEQIEELKRQNELRQEMLDD 1763
+ + + E Q++L++
Sbjct: 528 SIVDIANKRSSSAEESGQDVLEN 550
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 224 bits (571), Expect = 6e-58
Identities = 366/1733 (21%), Positives = 738/1733 (42%), Gaps = 300/1733 (17%)
Query: 173 EINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDH 232
E + SN + L SE+ W + + ++ S N++ + +Q R+++
Sbjct: 468 ESDVFSNTLDTL-SEI-EWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEK---- 521
Query: 233 QHEMSVLQNAHQQKLTEISRRHREELSDYE----ERIEELENLLQQGGSGVIETDLSKIY 288
E L+ + L E R+ D E I L+NL++ + V DL
Sbjct: 522 --EEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKH--AEVYNQDLEN-- 575
Query: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIK------DINKKLSSAENDRDILRR----EQEQ 338
E+ +++L+ EK + KK+++ D K D++ L S E+ + + + E
Sbjct: 576 ELSSKVELLR-EKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVA 634
Query: 339 LNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEV-FRLQQALSDA 397
L+ ++ ENL+L+ K++ A + + +Q + +++ L++ L A
Sbjct: 635 LDAKRESAFLRSENLELK-EKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSA 693
Query: 398 ENEIMRLSSLNQDNSLAED---NLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEV 454
NEI +L+SL D + +D NL+L+ +I L+KE + +E E L+ ++ L+
Sbjct: 694 FNEITKLTSLI-DGKVPKDLLCNLELEGKITDLQKELNKEVEENEALREEVILLSE---- 748
Query: 455 IKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILI 514
+KS L SE+ LR ++ K +EL+ SEK+ L +E+ + + Q + +
Sbjct: 749 LKS-------LPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKT 801
Query: 515 KDQLSKQQNEGDSI------ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSE 568
KD L+ Q+ S L D + K V + + L + +K S
Sbjct: 802 KDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSL 861
Query: 569 VAL-NDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN-EEELSRIRNE 626
AL +L Q+L++K + ++LN+ ++ KE LE ++ Q E E + I +
Sbjct: 862 GALKTELSYKTQELQEKTREVQERLNEMEQ-----LKEQLENRDSTLQTVEREKTLITEK 916
Query: 627 LMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLAC 686
L Q+L EV+ L Q +L+QL E+L+ +K + V
Sbjct: 917 LQQTLE-----------------EVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMN 959
Query: 687 EDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEEL 746
D + QL L Q + TLK + E + ++ E +++++ + +
Sbjct: 960 IDTQEQLRNALESLKQ----HQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGI 1015
Query: 747 SNARNL---NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQ 803
++L NT L + KD EI E ++ I + + E + +L S + E+
Sbjct: 1016 DKKQDLEAKNTQTLTAD---------VKDNEIIEQQRKIFSLIQEKNELQQMLESVIAEK 1066
Query: 804 KQL-TQLINKKEIFIEKLKERSSKLQEELDKYSQ--ALRKNEILRQTIEEKDRSLGSMKE 860
+QL T L E+ IE +E L +EL K + A KN +++ E R+ + E
Sbjct: 1067 EQLKTDLKENIEMTIEN-QEELRLLGDELKKQQEIVAQEKNHAIKKE-GELSRTCDRLAE 1124
Query: 861 ENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE 920
L+E+ ++L+E+Q + V + ++E+ +++++ E+L+ E+K+ + +E
Sbjct: 1125 VEEKLKEKSQQLQEKQQQLLNVQ-----EEMSEMQKKINEI----ENLKNELKNKELTLE 1175
Query: 921 DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH 980
+++L Q L E +E+ + ++ + +K LQK+ E + L
Sbjct: 1176 HMETERLELAQKLNENYEEV---------------KSITKERKVLKELQKSFETERDHLR 1220
Query: 981 EERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNI 1040
++I+ +E K+ ++++ E
Sbjct: 1221 GYIREIEATGLQTKEELKIAHIHLKEHQE------------------------------- 1249
Query: 1041 SLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREK 1100
ID+L + K QII +DLE SHT+ LQ+++ E+E
Sbjct: 1250 ----TIDELRRSVSEKTAQIINTQDLE----------KSHTK----LQEEIPVLHEEQEL 1291
Query: 1101 VFAVLNEKTRENSHLKTEYHKMMDIVAAKEA-ALIKLQDENKKLSTRFESSGQDMFRETI 1159
+ V ++ E E + + K++ L +++ E +L+ +F+ S +++ T
Sbjct: 1292 LPNV--KEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTK 1349
Query: 1160 Q--NLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQ 1217
+ NL I +++ D L + + LA +Q S + E S +E E K+
Sbjct: 1350 ERDNLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQE----QSLNMKEKDNETTKI--- 1402
Query: 1218 VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQN 1277
V +ME++K + +SA L+ E+ L GL + +++
Sbjct: 1403 VSEMEQFKPK----------DSALLRIEIEML-------------------GLSKRLQES 1433
Query: 1278 ETKLKNFGQELAQVQHSIGQLCNTKDLLLGKL-DIISPQLSSASLLTPQSAECLRASKSE 1336
++K+ +E +Q L + D L + +I++ L + L + A C + E
Sbjct: 1434 HDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEEL--KVAHCCLKEQEE 1491
Query: 1337 VLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIA-ATSELERKEHEQTDSEI 1395
++ ELR +L EK+ I T+Q+ ++D + E+ KE + +I
Sbjct: 1492 TIN-----------ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQI 1540
Query: 1396 KQLKEKQDVLQKL---LKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL 1452
+++EK + L++ K KD +++ ++L E +++ + +K
Sbjct: 1541 SEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQE 1600
Query: 1453 ILEMDIGKLKGENEKIVETYR-GKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFE 1511
L+++ +LK ++IV + +E EYQ L+ T + + +EK E +KE+ +
Sbjct: 1601 ALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNET---QEKMCEIEHLKEQ-FETQ 1656
Query: 1512 QLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLR 1571
+L E + + L Q+L+ ++++E V +ERD + + ++E L+ ++
Sbjct: 1657 KLNLENIETENIRLTQILH--ENLEEMRSV-TKERDDLRSVEETLKVERDQLKENLRETI 1713
Query: 1572 DKEFRSNQELERLRNHLLESEDS-----------------------YTREALAAEDREA- 1607
++ +EL+ + HL E +++ ++ +AL A+D +
Sbjct: 1714 TRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 1608 ------------------KLRKKVTVLEEKLVSSSNAMENASHQASVQVESL---QEQLN 1646
KLR V+ +KL + +EN++ + +++ L + QL
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 1647 VVSKQRDETALQLSVSQE---QVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIA 1703
+ K +ET ++S ++ Q+K +L+L+ L+ +E+ +K LE+ K ++
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLE--IENLNLAQK--LHENLEEMKSVMK 1889
Query: 1704 E---WKKNAENLEGKVISLQECLDEANA-------ALDSASRLTEQLDVKEEQIEELKRQ 1753
E ++ E L+ + L+E L E A L +A L+++ +E +++L+ +
Sbjct: 1890 ERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKE---HKETVDKLREK 1946
Query: 1754 NELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLM 1806
+ + D+QK L + + K+ ++ + L + N H+ + M
Sbjct: 1947 ISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Score = 213 bits (542), Expect = 1e-54
Identities = 342/1648 (20%), Positives = 714/1648 (43%), Gaps = 188/1648 (11%)
Query: 252 RRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQL 311
+R+R+E+ D ++++EE+ L+ + + L+++ E + +Q +Q EK+E+ +M
Sbjct: 346 KRYRKEIMDLKKQLEEVS--LETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVT 403
Query: 312 EDKIKDINKKLSSAENDRDI--LRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSD 369
+ + ++L + R L + + N N+ + KL + +++ D
Sbjct: 404 SSSLT-LQQELKAKRKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREID 462
Query: 370 TMTEKERILAQSASVEEVF-RLQQALSDAE-NEIMRLSSLNQDNSLAEDNLKLKMRIEVL 427
E + ++S +VF LS+ E N +L LNQ+N +E N L+ + L
Sbjct: 463 -----ESVCSES----DVFSNTLDTLSEIEWNPATKL--LNQENIESELN-SLRADYDNL 510
Query: 428 EKEKSLLSQEKEELQMSLLKLNN--EYEVIKSTATRDISLD-----SELHDLRLNLEAKE 480
+ L EKEE+++ L + N+ E+E ++ +D + S L +L + E
Sbjct: 511 VLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQLIHEISNLKNLVKHAEVYN 570
Query: 481 QELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI-ISKLKQDLNDE 539
Q+L +S K L+ E E DQ+ K Q DS + +K DL+
Sbjct: 571 QDLENELSSKVELLREKE-----------------DQIKKLQEYIDSQKLENIKMDLSYS 613
Query: 540 KKRVHQLEDDKMDI----TKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKS 595
+ + + K + T LD ++E L +L++K++ L K
Sbjct: 614 LESIEDPKQMKQTLFDAETVALDAKRESAF--------LRSENLELKEKMKELATTY-KQ 664
Query: 596 QESNVSIQKENLELKEHIRQN-EEELSRIRNELMQSLNQDSNSNFKDTLLK-EREAEVRN 653
E+++ + + LE K+ ++ + E+EL NE+ + + KD L E E ++ +
Sbjct: 665 MENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLELEGKITD 724
Query: 654 LKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVET 713
L++ L++ + NE L++ + E + L E +R ++++ + ++ EK+ +
Sbjct: 725 LQKELNKEVEENEALREEVI-LLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSE 783
Query: 714 LKMEKGEIEA---ELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQK 770
+ ++ ++ E+ K L + Y+ T +E N + L+ Q +++ +++ N++
Sbjct: 784 VVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQ-KYKMVLEENER 842
Query: 771 KDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
+ EI L K ++ D+ K LS +E ++ T+ + ++ +E+LKE+
Sbjct: 843 MNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDST 902
Query: 831 LDKYSQALRK-NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLD 889
L + E L+QT+EE ++L K++ LQE L+ R++ +D
Sbjct: 903 LQTVEREKTLITEKLQQTLEEV-KTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNID 961
Query: 890 SVTELASEVSQL-------NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 942
+ +L + + L NT+K + EE+ + + E+ ++K + Q + K+ D
Sbjct: 962 TQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQD- 1020
Query: 943 FRYQHEQMNATHTQLFLE--KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQ 1000
+ A +TQ KD EI Q+ I L +E+ ++Q + E +
Sbjct: 1021 -------LEAKNTQTLTADVKDNEIIEQQRKI----FSLIQEKNELQQMLESVIAEKEQL 1069
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSK--DEVGKLT 1058
+++ E + E RL+ +++ EI + EKN ++ K+ +LS+ D + ++
Sbjct: 1070 KTDLKENIEM-TIENQEELRLLGDELKKQQEI-VAQEKNHAIKKE-GELSRTCDRLAEVE 1126
Query: 1059 QIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTE 1118
+ +++K ++Q ++ + ++Q E E + L K H++TE
Sbjct: 1127 EKLKEKSQQLQEKQQQLLNVQEEMS------EMQKKINEIENLKNELKNKELTLEHMETE 1180
Query: 1119 YHKMMDIVAAKEAALIKLQDENK---KLSTRFESSGQDMFRETIQNLSR--IIREKDIEI 1173
++ + + + E K +L FE+ +D R I+ + + +++++I
Sbjct: 1181 RLELAQKLNENYEEVKSITKERKVLKELQKSFETE-RDHLRGYIREIEATGLQTKEELKI 1239
Query: 1174 DALSQK-CQTLLAVLQTSSTGNEAGGVNSNQFEE----------LLQERDKLKQQVKKME 1222
+ K Q + L+ S + A +N+ E+ +L E +L VK++
Sbjct: 1240 AHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEVS 1299
Query: 1223 EWKQQV--------------MTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYT 1268
E ++ + TT+ ++ E +L E+ + Q ++ + L+
Sbjct: 1300 ETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKE 1359
Query: 1269 GLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAE 1328
L ++Q + ++ ++ + Q Q N K+ K + + +S P+ +
Sbjct: 1360 ALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKE----KDNETTKIVSEMEQFKPKDSA 1415
Query: 1329 CLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1388
LR + E+L S L Q+ +E++ +EKD ++ LQE SD + + +H
Sbjct: 1416 LLRI-EIEMLGLSKRL-QESHDEMKSVAKEKD-DLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 1389 EQTDSEIKQ----LKEKQDVLQKL---LKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
+T+ E+K LKE+++ + +L L EK+ I QL + N+ NK+ E
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE----- 1527
Query: 1442 QAVTNLKERILILEM-DIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFEC 1500
+ +E+ I ++ ++ + E ++ E + K++ Q+++ ++ + L+E + E
Sbjct: 1528 --IYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585
Query: 1501 HSM---KEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQ 1557
M KE+ ++ L+ + +++ +K QEK F + K +
Sbjct: 1586 QIMIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE 1645
Query: 1558 MENTALQNEVQRLRDKEFRS-NQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVL 1616
+E+ Q E Q+L + + N L ++ + LE S T+E R + +
Sbjct: 1646 IEHLKEQFETQKLNLENIETENIRLTQILHENLEEMRSVTKE-----------RDDLRSV 1694
Query: 1617 EEKL-VSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLAN 1675
EE L V EN + +E QE+L +V E + + V + ++N
Sbjct: 1695 EETLKVERDQLKENLRETITRDLEK-QEELKIVHMHLKEHQETIDKLRGIVSEKTNEISN 1753
Query: 1676 LQMVLEHFQ----------QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDE 1725
+Q LEH QEE + L++Q++ I + + K+ ++Q+ L+
Sbjct: 1754 MQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLEN 1813
Query: 1726 ANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMR 1785
+NA L ++L E Q+ LK+ Q+ + ++++ + + S + K+ +
Sbjct: 1814 SNAKLQEK---IQELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSL-TLSKLEIE 1869
Query: 1786 NLFIGHFHTPKNQRHEVLRLMGSILGVR 1813
NL + + HE L M S++ R
Sbjct: 1870 NLNLA------QKLHENLEEMKSVMKER 1891
Score = 203 bits (517), Expect = 1e-51
Identities = 332/1603 (20%), Positives = 696/1603 (43%), Gaps = 280/1603 (17%)
Query: 36 DMLMEGTEEVEAELPDSRTKEIEAI-----HAI------------LRSENERLKKLCTDL 78
+M +E EE+ L D K+ E + HAI L E+LK+ L
Sbjct: 1078 EMTIENQEELRL-LGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQL 1136
Query: 79 EEKH--------EASEIQIK-QQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQ 129
+EK E SE+Q K + + +N+L+ KE+ + H++ ++ L +L
Sbjct: 1137 QEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKL-------- 1188
Query: 130 SVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVG 189
+ ++ ++ S +E L E+E
Sbjct: 1189 -------------------------------NENYEEVKSITKERKVLKELQKSFETERD 1217
Query: 190 HWRHIAQTSKAQGTDNSDQSEICKL-----QNIIKELKQNRSQEIDDHQHEMSVLQNAHQ 244
H R + +A G ++ +I + Q I EL+++ S++ + L+ +H
Sbjct: 1218 HLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQD-LEKSHT 1276
Query: 245 QKLTEISRRHRE--------ELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQV 296
+ EI H E E+S+ +E + ELE L +Q + + T+
Sbjct: 1277 KLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTT-----------KDSTTLAR 1325
Query: 297 LQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLE 356
+++E++ +K ++ +++IK + K +RD L+ +E L V+ Q+ E +++
Sbjct: 1326 IEMERLRLNEKFQESQEEIKSLTK-------ERDNLKTIKEALEVKHDQLKE---HIRET 1375
Query: 357 CSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQ---QALSDAENEIMRLSSLNQDN-- 411
+K+Q S KQ ++ KE+ + V E+ + + AL E E++ LS Q++
Sbjct: 1376 LAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Query: 412 ---SLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSE 468
S+A++ L+ EVL+ E L + +E+ L+ E +V +
Sbjct: 1436 EMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQ---EET 1492
Query: 469 LHDLRLNLEAKEQELN------QSISEK-ETLIAEIEELDRQN--------QEATKHMIL 513
+++LR+NL KE E++ ++I++K + I EI E + Q QE +
Sbjct: 1493 INELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQ 1552
Query: 514 IKDQLSKQQNEGDSIISKLKQDLN----------------DEKKRVH---QLEDDKM-DI 553
K+ + + SI SK+ + N +E KRV Q+E D++ +
Sbjct: 1553 FKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQIERDQLKEN 1612
Query: 554 TKELDVQKEKLIQSE---VALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELK 610
TKE+ + ++ + E + + ++ T++K+ + +E+L +Q + + +I+ EN+ L
Sbjct: 1613 TKEIVAKMKESQEKEYQFLKMTAVNETQEKMCE-IEHLKEQFETQKLNLENIETENIRLT 1671
Query: 611 EHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKK 670
+ + +N EE+ + E +D + ++TL ER+ NL++ ++ + E LK
Sbjct: 1672 QILHENLEEMRSVTKE------RDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKI 1725
Query: 671 VAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKK 730
V +K E + V + E N Q LE + + LK + +I+ EL A
Sbjct: 1726 VHMHLKEHQETIDKLRGIVSEKTNEI--SNMQKDLEHSN--DALKAQDLKIQEELRIAHM 1781
Query: 731 RLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHK 790
L E+ ++TI++L + T L + L N K +I ELK N Q+ T K
Sbjct: 1782 HLKEQ----QETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837
Query: 791 ETKDVLSSSLEEQKQLTQLINKKEIFIEKLK----ERSSKLQEELDKYSQALRKNEILRQ 846
+ + + E +QL + I + + + KL+ + KL E L++ +++ + LR+
Sbjct: 1838 DVNET-QKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRR 1896
Query: 847 TIEEKDRSLGSMKEENNHLQEELERLR------EEQSRTAPVADPKTLDSVTELASEVS- 899
E ++K E + L+E L+ + +++ +TA + + ++V +L ++S
Sbjct: 1897 VEE-------TLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE 1949
Query: 900 ---QLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQE----QKK--EMDEFRYQHEQM 950
Q++ I++ L++ QK I++ + ++QLL+ ++ KK EM++ + Q E
Sbjct: 1950 KTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQ 2009
Query: 951 NATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETK--VQSL------ 1002
N + + ++ + K L +++E+I+ + +ER +++ + E + +L
Sbjct: 2010 NLSMQSVRMDNFQLTKKLHESLEEIRI-VAKERDELRRIKESLKMERDQFIATLREMIAR 2068
Query: 1003 ---NIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQ 1059
N + EK LS + + L + ++E+ IK L ++ + + L++ + +
Sbjct: 2069 DRQNHQVKPEKRLLSDGQ-QHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKE 2127
Query: 1060 IIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEY 1119
I QK+L ++ + A +S + YLQ + EK+F N E+
Sbjct: 2128 IEFQKELSMR-VKANLS-------LPYLQTK------HIEKLFTA-------NQRCSMEF 2166
Query: 1120 HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR-EKDIEIDA--- 1175
H++M + + + K+++E + +FE D + + L +I ++D ++ +
Sbjct: 2167 HRIMKKLKYVLSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSREL 2226
Query: 1176 ----LSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTT 1231
L+Q + + + +E + + +F+++L R ++ Q +++ + +
Sbjct: 2227 RDLKLNQNMDLHIEEILKDFSESEFPSIKT-EFQQVLSNRKEMTQFLEEWLNTRFDIEKL 2285
Query: 1232 VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQV 1291
+Q E+ ++ + + +++ + +++ + + + +EQ+ LK ++L +
Sbjct: 2286 KNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKN 2345
Query: 1292 QHSIG-QLCNTKDLLLGKLDIISPQLSS-ASLLTPQSAE----CLRASKSEVLSESSELL 1345
++ L + + D +P ++S A+ LT + L +K + + S+++
Sbjct: 2346 YQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKII 2405
Query: 1346 --QQELE-------ELRKSLQEKDATIRTLQENNHRLSDSIAATS--------------- 1381
Q+ELE +L+ + E + + +E L D +A +
Sbjct: 2406 KMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLV 2465
Query: 1382 --ELER----KEHEQTDSEIKQLKEKQDVLQKLLKE--------KDLLIKAKSDQLLSSN 1427
+LE+ KE E+ S K E Q + +LL+E +D + ++ SN
Sbjct: 2466 KIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSN 2525
Query: 1428 ENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVE 1470
+ T + LK + LE +I KLK +NE++++
Sbjct: 2526 KPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIK 2568
Score = 197 bits (501), Expect = 8e-50
Identities = 394/1969 (20%), Positives = 828/1969 (42%), Gaps = 255/1969 (12%)
Query: 12 LGQSLGQVGGSLASLTGQISN-FTKDMLMEGTEEVEAELPDSR---TKEIEAIHAILRSE 67
L + L + LT I KD+L E+E ++ D + KE+E E
Sbjct: 686 LEKELQSAFNEITKLTSLIDGKVPKDLLCN--LELEGKITDLQKELNKEVE--------E 735
Query: 68 NERLKKLCTDLEE-KHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQS 126
NE L++ L E K SE++ R ++Q K E+ + + + L +++ +S
Sbjct: 736 NEALREEVILLSELKSLPSEVE------RLRKEIQDKSEELHIITSEKDKLFSEVVHKES 789
Query: 127 AAQSVPSGAGVP----ATTASS--SFAYGISHHPSAFHDDDMDFGDIISSQ----QEINR 176
Q + G ATT S+ S + + D + + ++ QEI
Sbjct: 790 RVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVN 849
Query: 177 LSNEVSRLESEVGHWRHIA--QTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQH 234
LS E + +S +G + +T + Q Q + +++ + KE +NR + +
Sbjct: 850 LSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQL-KEQLENRDSTLQTVER 908
Query: 235 EMSVLQNAHQQKLTEISR--RHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQK 292
E +++ QQ L E+ + +++L +E ++ + L+ + ++ +++
Sbjct: 909 EKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRN 968
Query: 293 TIQVL-QIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECE 351
++ L Q ++ +T K + E+ ++++ + ++ E + +Q+ + ++K+Q +E
Sbjct: 969 ALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEF---QQKMVGIDKKQDLEAKN 1025
Query: 352 NLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSD--AENEIMRLSSLNQ 409
L VK ++ + ++ +I + ++E LQQ L AE E ++
Sbjct: 1026 TQTLTAD------VKDNEIIEQQRKIFSL---IQEKNELQQMLESVIAEKEQLKTDLKEN 1076
Query: 410 DNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSEL 469
E+ +L++ + L+K++ +++QEK +K E + T R ++ +L
Sbjct: 1077 IEMTIENQEELRLLGDELKKQQEIVAQEKNHA----IKKEGE---LSRTCDRLAEVEEKL 1129
Query: 470 HDLRLNLEAKEQEL---NQSISEKETLIAEIEELDRQ--NQEAT-KHMILIKDQLSKQQN 523
+ L+ K+Q+L + +SE + I EIE L + N+E T +HM + +L+++ N
Sbjct: 1130 KEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLN 1189
Query: 524 EGDS---IISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ----KEKLIQSEVALNDLHL 576
E I+K ++ L + +K D +E++ KE+L + + L +
Sbjct: 1190 ENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQE 1249
Query: 577 TKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRN-----ELMQSL 631
T +L V Q+ +Q+ ++K + +L+E I EE + N E +++
Sbjct: 1250 TIDELRRSVSEKTAQIINTQD----LEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETM 1305
Query: 632 NQ----DSNSNFKD-TLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLAC 686
N+ S KD T L E E L + E ++ ++L K ++K E L +
Sbjct: 1306 NELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKH 1365
Query: 687 EDVRHQLEECLAG--NNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIE 744
+ ++ + E LA +Q E++ ++ E +I +E+ K + ++ IE
Sbjct: 1366 DQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK---DSALLRIEIE 1422
Query: 745 ELSNARNLNTS-----ALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSS 799
L ++ L S ++ E + L +L + E +LK+NI+++ H ET++ L +
Sbjct: 1423 MLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVA 1482
Query: 800 LEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKN--EILRQTIEEKDRSLGS 857
K+ + IN+ + + + + S +Q++L+ + L+ EI + + + +
Sbjct: 1483 HCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFNIKQISE 1542
Query: 858 MKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNT-IKEHLEEEIKHHQ 916
++E+ N L++ E + + S + + K L+ L ++ IKE +EE+K Q
Sbjct: 1543 VQEKVNELKQFKEHRKAKDSALQSI-ESKMLELTNRLQESQEEIQIMIKE--KEEMKRVQ 1599
Query: 917 KIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATH-TQLFLEKDEEIKSLQKT---- 971
+ ++ + + + + + KE E YQ +M A + TQ + + E +K +T
Sbjct: 1600 EALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQFETQKLN 1659
Query: 972 IEQIKTQ-------LHEERQDIQ--TDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
+E I+T+ LHE ++++ T D + + ++L +E K +L + T L
Sbjct: 1660 LENIETENIRLTQILHENLEEMRSVTKERDDLRSVE-ETLKVERDQLKENLRETITRDLE 1718
Query: 1023 KG---------IKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQA--- 1070
K +KE + I L T +I + KD + ++ +DL+IQ
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKD-LEHSNDALKAQDLKIQEELR 1777
Query: 1071 -LHARISSTSHTQD-----VVYLQQQLQAYAMEREKVFAVLNEKTRE---NSH----LKT 1117
H + T D V +L + E A L EK +E N H LK
Sbjct: 1778 IAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKK 1837
Query: 1118 EYHKMMDIVAAKEA----------ALIKLQDENKKLSTRFESSGQDM--FRETIQNLSRI 1165
+ ++ V+ E L KL+ EN L+ + + ++M + NL R+
Sbjct: 1838 DVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRV 1897
Query: 1166 IREKDIEIDALSQKCQ-TLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQV------ 1218
+E D L + Q T L+ A ++ E + + R+K+ ++
Sbjct: 1898 EETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEKTIQISDI 1957
Query: 1219 -KKMEEWKQQVMTTVQNMQHESAQLQE-------------ELHQLQAQVLVDSDNNSKLQ 1264
K +++ K ++ +Q +Q + QL E+ QL+ Q + + ++
Sbjct: 1958 QKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVR 2017
Query: 1265 VDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKL------DIISPQLSS 1318
+D L + ++ +++ +E +++ L +D + L D + Q+
Sbjct: 2018 MDNFQLTKKLHESLEEIRIVAKERDELRRIKESLKMERDQFIATLREMIARDRQNHQVKP 2077
Query: 1319 ASLLTPQSAECLRASKSEVLSESSELLQQ--ELEELRKSLQEKDATIRTLQENNHRLSDS 1376
L + L S E S ELL++ E+++ + L + E LS
Sbjct: 2078 EKRLLSDGQQHLTESLREKCSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMR 2137
Query: 1377 IAATSEL---ERKEHEQTDSEIKQLK-EKQDVLQKLLKEKDLLIKAKSDQLLSSNE---N 1429
+ A L + K E+ + ++ E +++KL + K K +Q S N+ +
Sbjct: 2138 VKANLSLPYLQTKHIEKLFTANQRCSMEFHRIMKKLKYVLSYVTKIKEEQHESINKFEMD 2197
Query: 1430 FTNKVNENELLRQAVTNLKERILILEMDIGKLK-GEN-----EKIVETYRGKE-----TE 1478
F ++V + + L + +L++ + ++ LK +N E+I++ + E TE
Sbjct: 2198 FIDEVEKQKELLIKIQHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTE 2257
Query: 1479 YQALQETNMKFSMMLRE---KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
+Q + + + L E F+ +K + + + ++N
Sbjct: 2258 FQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEF 2317
Query: 1536 QEKTVVFQQERDQVMLALKQK-------------------QMENTALQNEVQRLRDKEFR 1576
+E++ +E +Q + +LK+K Q+ T N+ + + +
Sbjct: 2318 EERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQ 2377
Query: 1577 -SNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQAS 1635
+ +++ L N L E+++S A+ E + K++K++ V + + ++ H+++
Sbjct: 2378 LTTEKIRELENSLHEAKES----AMHKESKIIKMQKELEVTNDIIAK----LQAKVHESN 2429
Query: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMV----LEHFQQEEKAMY 1691
+E +E + V+ +D+ AL +E+++ + L + + + F++E A
Sbjct: 2430 KCLEKTKETIQVL---QDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISAT- 2485
Query: 1692 SAELEKQKQLIAEWKKNAENLEG----KVISLQECLDEANAALDSAS-----RLTEQLDV 1742
A +E QK++I ++N + VIS +N L + T+ L +
Sbjct: 2486 KATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALIL 2545
Query: 1743 K------EEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMR 1785
K E++I +LK+QNE + +++ L+N + ++ L R
Sbjct: 2546 KSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLSNEVKTWKERTLKR 2594
Score = 191 bits (484), Expect = 8e-48
Identities = 325/1672 (19%), Positives = 717/1672 (42%), Gaps = 273/1672 (16%)
Query: 168 ISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQ 227
I +Q+E+ L +E+ + + V ++ A K +G + S C ++E + +SQ
Sbjct: 1081 IENQEELRLLGDELKKQQEIVAQEKNHA--IKKEG----ELSRTCDRLAEVEEKLKEKSQ 1134
Query: 228 EIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKI 287
++ + Q ++ +Q EE+S+ +++I E+ENL + +
Sbjct: 1135 QLQEKQQQLLNVQ---------------EEMSEMQKKINEIENLKNE------------L 1167
Query: 288 YEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIM 347
+ T++ ++ E++E +K+ + +++K I K +R +L+ Q+ E+ +
Sbjct: 1168 KNKELTLEHMETERLELAQKLNENYEEVKSITK-------ERKVLKELQKSFETERDHLR 1220
Query: 348 EECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSL 407
++E + LQ + + KE E + L++++S+ +I+ L
Sbjct: 1221 GYIR--EIEATGLQTKEELKIAHIHLKEH-------QETIDELRRSVSEKTAQIINTQDL 1271
Query: 408 NQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI-KSTATRDISLD 466
+ ++ KL+ I VL +E+ LL KE + + NE E++ + + T+D +
Sbjct: 1272 EKSHT------KLQEEIPVLHEEQELLPNVKEVSETQ--ETMNELELLTEQSTTKDSTTL 1323
Query: 467 SELHDLRLNLEAKEQELNQSIS----EKETLIAEIEELDRQNQEATKHMILIKDQLSKQQ 522
+ + RL L K QE + I E++ L E L+ ++ + +H I++ L+K Q
Sbjct: 1324 ARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEH---IRETLAKIQ 1380
Query: 523 NEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEK---LIQSEVALNDLHLTKQ 579
SK +Q LN ++K +++ I E++ K K L++ E+ + L Q
Sbjct: 1381 ESQ----SKQEQSLNMKEK-----DNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQ 1431
Query: 580 KLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNF 639
+ D+++++ + + Q +Q E+ +LKE+I++ + + L +
Sbjct: 1432 ESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEI----------VAKHLETEEELKV 1481
Query: 640 KDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAG 699
LKE+E + L+ NLSE E ++K ++ N+KL +++ + E+
Sbjct: 1482 AHCCLKEQEETINELRVNLSEKETEISTIQK---QLEAINDKLQNKIQEIYEKEEQFNIK 1538
Query: 700 NNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQL 759
EK ++ K + ++ L + ++LE N+ +++ EE+ +
Sbjct: 1539 QISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQ--------IMIK 1590
Query: 760 EHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDV------LSSSLEEQKQLTQLINKK 813
E E + ++ + +E +LK+N +++ KE+++ +++ E Q+++ ++ + K
Sbjct: 1591 EKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLK 1650
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKN-EILRQTIEEKD--RSLG-SMKEENNHLQEEL 869
E F E K ++ E + +Q L +N E +R +E+D RS+ ++K E + L+E L
Sbjct: 1651 EQF-ETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENL 1709
Query: 870 ERL------REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQN 923
++E+ + + + +++ +L VS+ +++++++H ++ Q+
Sbjct: 1710 RETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQD 1769
Query: 924 QSKMQLLQ----SLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
+ L+ L+EQ++ +D+ R + EK +++ ++QK +E +L
Sbjct: 1770 LKIQEELRIAHMHLKEQQETIDKLR-----------GIVSEKTDKLSNMQKDLENSNAKL 1818
Query: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKN 1039
E+ Q+++ + Q + ++ + +E E+L K IK++ L + L +N
Sbjct: 1819 QEKIQELKANEH--------QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIEN 1870
Query: 1040 ISLTKQIDQ-----------------------LSKDEVGKLTQIIQQKDLEIQA--LHAR 1074
++L +++ + L +D++ + Q + +DLEIQ AR
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTAR 1930
Query: 1075 ISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI 1134
+ S H + V L++++ ++ +++ ++ K E K + + KE L+
Sbjct: 1931 MLSKEHKETVDKLREKISEKTIQ-------ISDIQKDLDKSKDELQKKIQELQKKELQLL 1983
Query: 1135 KLQD----------ENKKLSTRFESSGQDMFRETIQN--LSRIIREKDIEIDALSQKCQT 1182
++++ E ++L +FE+ M + N L++ + E EI ++++
Sbjct: 1984 RVKEDVNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDE 2043
Query: 1183 LLAVLQTSSTGNEAGGVNSNQFEELLQE---RDKLKQQVKKMEEWKQQVMTTVQNMQHES 1239
L + E+ + +QF L+E RD+ QVK + + E
Sbjct: 2044 LRRI-------KESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREK 2096
Query: 1240 AQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLK-NFGQELAQVQH----- 1293
+EL + +++ + ++L +D I+ ++ ++K N Q +H
Sbjct: 2097 CSRIKELLKRYSEMDDHYECLNRLSLDLEKEIEFQKELSMRVKANLSLPYLQTKHIEKLF 2156
Query: 1294 SIGQLCNTK-DLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSE---SSELLQQEL 1349
+ Q C+ + ++ KL + LS + + + E + + + + E ELL + +
Sbjct: 2157 TANQRCSMEFHRIMKKLKYV---LSYVTKIKEEQHESINKFEMDFIDEVEKQKELLIK-I 2212
Query: 1350 EELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQL----KEKQDVL 1405
+ L++ +R L+ N + + E +E +Q+ KE L
Sbjct: 2213 QHLQQDCDVPSRELRDLKLNQNMDLHIEEILKDFSESEFPSIKTEFQQVLSNRKEMTQFL 2272
Query: 1406 QKLLKEKDLLIKAKS------DQLLSSNENFTNKV----NEN-ELLRQAVTNLKERILIL 1454
++ L + + K K+ D++ N F N++ NE+ E ++ T KE
Sbjct: 2273 EEWLNTRFDIEKLKNGIQKENDRICQVNNFFNNRIIAIMNESTEFEERSATISKE----W 2328
Query: 1455 EMDIGKLKGENEKIVETYRGKETEYQALQETN----------------MKFSMMLREKEF 1498
E D+ LK +NEK+ + Y+ +T + + N + +RE E
Sbjct: 2329 EQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTTQDNKNPHVTSRATQLTTEKIRELEN 2388
Query: 1499 ECHSMKEKALAFEQ--LLKEKEQGKTGELNQLLNAV-----KSMQEKTVVFQQERDQVML 1551
H KE A+ E + +KE T ++ L A K +++ Q +D+V L
Sbjct: 2389 SLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVAL 2448
Query: 1552 ALKQKQMENTALQNEVQRLRDKEFRSNQELER------------------LRNHLLESED 1593
K + E L+ ++ ++ ++ ++ +E E+ LR +L S+
Sbjct: 2449 GAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQ 2508
Query: 1594 SYTREALAAEDREAKLRKKVTV-LEEKLVSSSNAMENASHQASV--QVESLQEQLNVVSK 1650
+ ++ K +T +V ++ A+ S + ++ L++Q + K
Sbjct: 2509 AQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIK 2568
Query: 1651 QRDETALQLSVSQEQVKQYALSL----ANLQMVLEHFQQEEKAMYSAELEKQ 1698
Q++E +VK + A+ Q+ E+ + K +A +KQ
Sbjct: 2569 QKNELLSNNQHLSNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQ 2620
Score = 131 bits (330), Expect = 6e-30
Identities = 254/1234 (20%), Positives = 491/1234 (39%), Gaps = 211/1234 (17%)
Query: 736 ANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKET--- 792
A ++ T + + N +N + E L+K +K EI +LKK +E++ + +
Sbjct: 319 ALQFASTAKYMKNTPYVNEVSTD---EALLKRYRK---EIMDLKKQLEEVSLETRAQAME 372
Query: 793 KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK--------NEIL 844
KD L+ LEE+ L ++ N+K + ++ SS L + + ++ R+ N++
Sbjct: 373 KDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAKRKRRVTWCLGKINKMK 432
Query: 845 RQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTE----------- 893
++ ++ + + L L R +E + TLD+++E
Sbjct: 433 NSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLN 492
Query: 894 -----------------LASEVSQLNTIKEHLEEEIKH----------HQKIIEDQNQSK 926
L + QL T KE +E ++K +K +DQ
Sbjct: 493 QENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQL 552
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTI-----EQIKTQLHE 981
+ + +L+ K + + E ++ +L EK+++IK LQ+ I E IK L
Sbjct: 553 IHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSY 612
Query: 982 ERQDIQT---------DNSDIFQETKVQS--LNIENGSEKHDLSKAET--ERLVKGIKER 1028
+ I+ D + + K +S L EN K + + T +++ I+
Sbjct: 613 SLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLY 672
Query: 1029 ELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQK-------DLEIQA--------LHA 1073
+ +++ + + L K++ Q + +E+ KLT +I K +LE++ L+
Sbjct: 673 QSQLEAKKKMQVDLEKEL-QSAFNEITKLTSLIDGKVPKDLLCNLELEGKITDLQKELNK 731
Query: 1074 RISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEA-- 1131
+ ++ V L +L++ E E++ + +K+ E + +E K+ V KE+
Sbjct: 732 EVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRV 791
Query: 1132 -----ALIKLQDENKKLSTRFESSGQDM-----------------------FRETIQNLS 1163
+ K +D+ + ++S+ Q+ + I NLS
Sbjct: 792 QGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLS 851
Query: 1164 RIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQV----- 1218
+ ++ D + AL + LQ + + Q +E L+ RD Q V
Sbjct: 852 KEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKT 911
Query: 1219 ---KKMEEWKQQVMTTVQ----------NMQHESAQLQEELHQLQAQVLVDSDNNSKLQV 1265
+K+++ ++V T Q ++Q E QL+ ++H V ++ D +L+
Sbjct: 912 LITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIHD---TVNMNIDTQEQLRN 968
Query: 1266 DYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGK---------LDIISPQL 1316
L Q E T +E+++ H TKD K L+ + Q
Sbjct: 969 ALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQT 1028
Query: 1317 SSASLLTPQSAECLRASKSEVLSESSELLQQ------ELEELRKSLQEKDATIRTLQENN 1370
+A + + E R S ++ E +EL Q E E+L+ L+E QE
Sbjct: 1029 LTADVKDNEIIEQQRKIFS-LIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEEL 1087
Query: 1371 HRLSDSIAATSEL--ERKEHE-QTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSN 1427
L D + E+ + K H + + E+ + ++ +++ LKEK ++ K QLL+
Sbjct: 1088 RLLGDELKKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQ 1147
Query: 1428 ENFT---NKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQE 1484
E + K+NE E L+ + N + + +E + +L + + E + E + L+E
Sbjct: 1148 EEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKE 1207
Query: 1485 TNMKFSM-------MLREKEFECHSMKEKALAFEQLLKEKEQ----------GKTGELNQ 1527
F +RE E KE+ LKE ++ KT ++
Sbjct: 1208 LQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIIN 1267
Query: 1528 LLNAVKS---MQEKTVVFQQERDQV----MLALKQKQMENTALQNEVQRLRDKEFRSNQE 1580
+ KS +QE+ V +E++ + ++ Q+ M L E +D + E
Sbjct: 1268 TQDLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIE 1327
Query: 1581 LERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVES 1640
+ERLR + E ++L E K K+ ++ + A Q S +S
Sbjct: 1328 MERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLKEHIRETLAKIQES---QS 1384
Query: 1641 LQEQ-LNVVSKQRDETALQLSVSQEQVKQYALSLANLQM--VLEHFQQEEKAMYSAELEK 1697
QEQ LN+ K + T + + Q + K AL ++M + + Q+ M S EK
Sbjct: 1385 KQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEK 1444
Query: 1698 ------QKQLIAE---WKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIE 1748
Q+ L +E K+N + + K + +E L A+ L +EE I
Sbjct: 1445 DDLQRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKE----------QEETIN 1494
Query: 1749 ELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
EL+ ++ + +QK+L ++ + + K+ ++
Sbjct: 1495 ELRVNLSEKETEISTIQKQLEAINDKLQNKIQEI 1528
Score = 80.5 bits (197), Expect = 2e-14
Identities = 173/817 (21%), Positives = 336/817 (41%), Gaps = 149/817 (18%)
Query: 998 KVQSLNIEN--GSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG 1055
KV LN+ + GSE+ + A RL +G +N L + I +LS +VG
Sbjct: 227 KVSHLNLVDLAGSERAAQTGAAGVRLKEGCN--------INRSLFILGQVIKKLSDGQVG 278
Query: 1056 --------KLTQIIQQK---DLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAV 1104
KLT+I+Q + + + + I+ S + + LQ A M+
Sbjct: 279 GFINYRDSKLTRILQNSLGGNAKTRII-CTITPVSFDETLTALQFASTAKYMKNTPY--- 334
Query: 1105 LNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSR 1164
+NE + + + LK ++MD+ K Q E L TR ++ +D L++
Sbjct: 335 VNEVSTDEALLKRYRKEIMDL---------KKQLEEVSLETRAQAMEKDQ-------LAQ 378
Query: 1165 IIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEW 1224
++ EKD+ ++K + L +L TSS+ L + +LK + K+ W
Sbjct: 379 LLEEKDLLQKVQNEKIENLTRMLVTSSS---------------LTLQQELKAKRKRRVTW 423
Query: 1225 KQQVMTTVQNMQHES-----AQLQEELHQLQAQVLVDSDNNSKLQVD-YTGLIQSYEQNE 1278
+ ++N + + + H+L +L + D + + D ++ + + + E
Sbjct: 424 CLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIE 483
Query: 1279 ----TKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASK 1334
TKL N QE ++ + L D L+ LD E LR K
Sbjct: 484 WNPATKLLN--QE--NIESELNSLRADYDNLV--LDY----------------EQLRTEK 521
Query: 1335 SEV---LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQT 1391
E+ L E ++L E E L + + KD ++ + E ++ L + + + +
Sbjct: 522 EEMELKLKEKNDL--DEFEALERKTK-KDQEMQLIHEISN-LKNLVKHAEVYNQDLENEL 577
Query: 1392 DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERI 1451
S+++ L+EK+D ++KL ++ + K + + + + + ++Q + + +
Sbjct: 578 SSKVELLREKEDQIKKL---QEYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVA 634
Query: 1452 LILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLR-EKEFECHSMKEKALAF 1510
L + + L+ EN ++ E + T Y+ ++ + L +K+ + KE AF
Sbjct: 635 LDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAF 694
Query: 1511 EQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRL 1570
++ K G++ + L ++ K Q+E L ++ EN AL+ EV L
Sbjct: 695 NEITKLTSL-IDGKVPKDLLCNLELEGKITDLQKE-------LNKEVEENEALREEVILL 746
Query: 1571 RDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENA 1630
+ + + E+ERLR + +D+ +L +T ++KL S
Sbjct: 747 SELKSLPS-EVERLRKEI--------------QDKSEELHI-ITSEKDKLFSE------V 784
Query: 1631 SHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAM 1690
H+ S +V+ L E+ + K +D+ L+ +Q K N + + F+Q+ K M
Sbjct: 785 VHKES-RVQGLLEE---IGKTKDD----LATTQSNYKSTDQEFQNFKTLHMDFEQKYK-M 835
Query: 1691 YSAELEKQKQLIAEWKKNAENLEG-----------KVISLQECLDEANAALDSASRLTEQ 1739
E E+ Q I K A+ + K LQE E L+ +L EQ
Sbjct: 836 VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQ 895
Query: 1740 LDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1776
L+ ++ ++ ++R+ L E L +++ +L +
Sbjct: 896 LENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKD 932
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 219 bits (559), Expect = 2e-56
Identities = 359/1691 (21%), Positives = 745/1691 (44%), Gaps = 257/1691 (15%)
Query: 180 EVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICK-LQNIIKELKQNRSQEIDDHQHEMSV 238
E + L+ V + S+ Q N D ++ K L+ ++ L+ N ++ ++ HE S+
Sbjct: 277 EKAELQDRVTELSALLTQSQKQ---NEDYEKMIKALRETVEILETNHTELME---HEASL 330
Query: 239 LQNAHQQKLTEISRRHREELSDYEE-RIEELENLLQQGG---SGVIETDLSKIYEMQKTI 294
+NA ++KL+ ++ + D + +EE +N+ Q G S +++ + ++ Q
Sbjct: 331 SRNAQEEKLS-----LQQVIKDITQVMVEEGDNIAQGSGHENSLELDSSIFSQFDYQDAD 385
Query: 295 QVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLK 354
+ L + + T++ + ++D+ ++L+ + ++L+++ +Q E + + + + L
Sbjct: 386 KALTLVRSVLTRRRQ----AVQDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLT 441
Query: 355 LECSKLQPSAVK---QSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDN 411
E L V + D+++ KER L Q A E L+Q L E E RL +N +
Sbjct: 442 GERDTLAGQTVDLQGEVDSLS-KERELLQKAREE----LRQQLEVLEQEAWRLRRVNVEL 496
Query: 412 SLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLN-NEYEVIKSTATRDISLDSELH 470
L D+ + + E ++E L +E+E LQ L+ L + E + T +L+S
Sbjct: 497 QLQGDSAQGQK--EEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREALESSHL 554
Query: 471 DLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIIS 530
+ L L ++ E+ +++ E IAE+ + + + +LS ++
Sbjct: 555 EGEL-LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLS-------ALNE 606
Query: 531 KLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVD 590
L D +++ QLE++ + ++ ++ +V L + ++ L +K +L
Sbjct: 607 ALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKRREALWEKNTHLEA 666
Query: 591 QLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNE------LMQSLNQDSNS------- 637
QL K++E+ +Q + +++E + +++LS R++ ++ L+Q++
Sbjct: 667 QLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLAR 726
Query: 638 --NFKDTLLKEREA-EVR---------NLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685
K+ L++E+ A EVR +L + L L E L+ F+ + +N + +
Sbjct: 727 AVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVT 786
Query: 686 CEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEE 745
+ Q++ + E + L E+ + E E A ++L + + + +E+
Sbjct: 787 KGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQ 846
Query: 746 LSNARNLNTSALQLEHE--------HLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLS 797
A + L+ + E L K + + E EL+ +++ T E + + +
Sbjct: 847 QKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQT---EMEAIQA 903
Query: 798 SSLEEQKQLTQLINKKEIFIEK----LKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853
EE+ Q + + ++ EK L E + Q+EL SQ L E LRQ D
Sbjct: 904 QREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQL---ERLRQ-----DM 955
Query: 854 SLGSMKEENNH--LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEE 911
+ +KE+ LQ +L+ + E A + D + L E S L K L+++
Sbjct: 956 KVQKLKEQETTGILQTQLQEAQRELKEAA----RQHRDDLAALQEESSSLLQDKMDLQKQ 1011
Query: 912 IKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEF---RYQHEQMNATHTQLFLEKDEEIKSL 968
++ + + Q+ S+ + Q +QE+ +E E+ + + E+ A+ T +EK++ + L
Sbjct: 1012 VEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVL 1071
Query: 969 QKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKER 1028
Q+ + +L RQD+Q E E+ +LS A+ E L + +KE+
Sbjct: 1072 QEADSIRQQELSALRQDMQ-----------------EAQGEQKELS-AQMELLRQEVKEK 1113
Query: 1029 EL-----EIKLLNEKNIS-LTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQ 1082
E E +LL E S +T+Q +L + ++ + L R+ ST
Sbjct: 1114 EADFLAQEAQLLEELEASHITEQ----------QLRASLWAQEAKAAQLQLRLRST---- 1159
Query: 1083 DVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK 1142
+ QL+A A E++ + + + L + Y +A + AL + + +
Sbjct: 1160 -----ESQLEALAAEQQP-----GNQAQAQAQLASLY-------SALQQALGSVCESRPE 1202
Query: 1143 LSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSN 1202
LS +S+ E QN +R + ++ LL L + + ++ +
Sbjct: 1203 LSGGGDSAPSVWGLEPDQNGARSLFKRG-----------PLLTALSAEAVASALHKLHQD 1251
Query: 1203 QFEELLQERDKLKQQVKKMEE-------WKQQVMTTVQNMQHESAQLQEELHQLQAQVLV 1255
+ + Q RD L+ QV+K+EE K QV T +Q++Q + +Q QEE + + +
Sbjct: 1252 LW-KTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK--- 1307
Query: 1256 DSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS-- 1313
+ L+ + L ++ +++L+ + + Q L K+ L +++ +
Sbjct: 1308 ----QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQAA 1363
Query: 1314 -----PQLSSASLLTPQSAECLRASKS--EVLSESSELLQQELEELRKSLQEKDATIRTL 1366
Q S+A +L E LR ++S ++ +E E ++ + L++ + K A + L
Sbjct: 1364 VVEARAQASAAGIL----EEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKAL 1419
Query: 1367 QENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSS 1426
QEN L+ ++A E E E +I++L++++++ + L+ L +K ++ ++
Sbjct: 1420 QENLALLTQTLAEREE----EVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQ 1475
Query: 1427 NENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETN 1486
E ++ E E R + +L + E KL + E+I E + +ET+ L+
Sbjct: 1476 QE----QIQELEKCRSVLEHLPMAVQEREQ---KLTVQREQIRELEKDRETQRNVLEHQL 1528
Query: 1487 M---KFSMMLREKEFECHSMKEKALAFE-----------------QLLKEKEQGKTGELN 1526
+ K M+ + + +K++ + E +L+KE E + +
Sbjct: 1529 LELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRV 1588
Query: 1527 QLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSN----QELE 1582
L + ++E++ Q + Q+ + +T L E+Q RD+E +S +EL+
Sbjct: 1589 ALTHLTLDLEERSQELQAQSSQI----HDLESHSTVLARELQE-RDQEVKSQREQIEELQ 1643
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRK-KVTVLEEKLVSSSNAMENASHQASVQVESL 1641
R + HL + L D+E L+K ++ VLE++ + +E Q + SL
Sbjct: 1644 RQKEHLTQD--------LERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKL---SL 1692
Query: 1642 QEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQL 1701
+E+ ++ QR + + K SL +++++L + +EK E+E Q++
Sbjct: 1693 RERGRELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLIL---RDKEK-----EVECQQEH 1744
Query: 1702 IAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELR---- 1757
I E ++ + LE ++ L + E + L S+ +++ V ++Q++E + Q EL+
Sbjct: 1745 IHELQELKDQLEQQLQGLHRKVGETSLLL---SQREQEIVVLQQQLQEAREQGELKEQSL 1801
Query: 1758 QEMLDDVQKKL 1768
Q LD+ Q+ L
Sbjct: 1802 QSQLDEAQRAL 1812
Score = 216 bits (550), Expect = 2e-55
Identities = 389/1904 (20%), Positives = 807/1904 (42%), Gaps = 295/1904 (15%)
Query: 23 LASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKH 82
L LTG+ +D L T +++ E+ DS +KE E +L+ E L++ LE++
Sbjct: 437 LQKLTGE-----RDTLAGQTVDLQGEV-DSLSKERE----LLQKAREELRQQLEVLEQEA 486
Query: 83 ---EASEIQIKQQSTSYRNQLQQKEVEISHLKARQIA-LQDQLLKLQSAAQSVPSGAGVP 138
++++ Q S + Q ++++ E+ HL R+ LQ+ L+ L++ S
Sbjct: 487 WRLRRVNVELQLQGDSAQGQKEEQQEEL-HLAVRERERLQEMLMGLEAKQSESLSELITL 545
Query: 139 ATTASSSFAYGISHHPSAFHDDDMDFGDIIS-SQQEINRLSNEVSRLESEVGHWRHIAQT 197
SS G + + ++ ++Q I LS+ + L++EV R A
Sbjct: 546 REALESSHLEG-----ELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLR--AAA 598
Query: 198 SKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREE 257
K + + + L + +L++ +Q + +NA Q L E +R RE
Sbjct: 599 VKLSALNEALALDKVGLNQQLLQLEEE-NQSVCSRMEAAEQARNALQVDLAEAEKR-REA 656
Query: 258 LSDYEERIEELENLLQQGGSGVIETDLSKIYE----MQKTIQVLQIEKVESTKKMEQLED 313
L + +E ++ G+ ++ DL I E +QK + + ++ +T ++EQL
Sbjct: 657 LWEKNTHLEAQLQKAEEAGAE-LQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQ 715
Query: 314 KIKDINKKLSSAENDRDILRREQEQLNV-------EKRQIMEECENLKLECSKLQPSAVK 366
+ K + L+ A +++ L RE+ L V +++ + E+ + L L+ S +
Sbjct: 716 EAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFE 775
Query: 367 -----------------QSDTMTEKERIL---AQSASVEEVFRLQQALSDAENEIMRLSS 406
Q T+T+ + ++ + +E QA + + +L+
Sbjct: 776 AQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQ 835
Query: 407 LNQDNSLAEDNLKLKMRIEV------LEKEKSL-----------LSQEKEELQMSLLKLN 449
Q+ A + K EV EKE+S L +EK EL+M L +
Sbjct: 836 AEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQ 895
Query: 450 NEYEVIKSTATRD-ISLDSELHDLRLNLEAKEQELNQSISEKETLIAEI-EELDRQNQEA 507
E E I++ + +S L ++L E + L +++ + + +A+ ++L+R Q+
Sbjct: 896 TEMEAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDM 955
Query: 508 TKHMI-------LIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ 560
+ +++ QL + Q E + + DL ++ L DKMD+ K+++
Sbjct: 956 KVQKLKEQETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDL 1015
Query: 561 KEKLIQSEVALNDLHLTKQKLEDKVE-----NLVDQLNKSQESNVSI---QKEN--LELK 610
K +L+ + + L +Q++++K+ N + + + +++++++ +KE L L+
Sbjct: 1016 KSQLVAQD---DSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQ 1072
Query: 611 EHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKE--REAEVRNLKQNLSELEQLN--- 665
E ++ELS +R ++ ++ + + + LL++ +E E L Q LE+L
Sbjct: 1073 EADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASH 1132
Query: 666 ---ENLKKVAFDVKMENEKLVLACEDVRHQLEECLA----GNN-QLSLEKNTIVETLKME 717
+ L+ + + + +L L QLE A GN Q + ++ L+
Sbjct: 1133 ITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQAQLASLYSALQQA 1192
Query: 718 KGEIEAELCWAKKRLL---EEANKYEKTIEELSNARNLN--------------TSALQLE 760
G + C ++ L + A + + AR+L SAL
Sbjct: 1193 LGSV----CESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKL 1248
Query: 761 HEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE-QKQLTQLINKKEIFIEK 819
H+ L K Q +D+ +++K +E+ TD + K + + L++ Q+QL+Q +K + K
Sbjct: 1249 HQDLWKTQQTRDVLRDQVQK-LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
Query: 820 ---LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQ 876
L+ +L E + LR+ E+ R + + L + KE +L ++E L+
Sbjct: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKE---NLTAQVEHLQA-- 1362
Query: 877 SRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQ 936
+V E ++ S ++E L + K+ ++ +S+ + Q+LQEQ
Sbjct: 1363 -------------AVVEARAQASAAGILEEDLRTA-RSALKLKNEEVESERERAQALQEQ 1408
Query: 937 KKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQE 996
+ ++ A TQ E++EE+++L+ I++++ Q ++ ++ + D+ +
Sbjct: 1409 GELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKR 1468
Query: 997 TKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD---- 1052
+ L E E + ++ E L ++ERE ++ + E QI +L KD
Sbjct: 1469 NQEVDLQQEQIQEL-EKCRSVLEHLPMAVQEREQKLTVQRE-------QIRELEKDRETQ 1520
Query: 1053 ---------EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFA 1103
E+ K Q+I+ + ++Q L ++ T + + L+ + + ME ++
Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLV----TLECLALELEENHHKMECQQKLI 1576
Query: 1104 VLNEKTREN-----SHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMF--R 1156
E RE +HL + + + A+ + + L+ + L+ + Q++ R
Sbjct: 1577 KELEGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQR 1636
Query: 1157 ETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ 1216
E I+ L R +K+ L ++ Q L+ Q E + D+ +
Sbjct: 1637 EQIEELQR---QKEHLTQDLERRDQELML-----------------QKERIQVLEDQRTR 1676
Query: 1217 QVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQ 1276
Q K +EE +Q+ +++ E Q +L Q +A+ + SK Q S E
Sbjct: 1677 QTKILEEDLEQIKLSLRERGRELTT-QRQLMQERAE---EGKGPSKAQRG------SLEH 1726
Query: 1277 NETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSE 1336
+ L++ +E+ Q I +L KD L +L + ++ SLL Q + E
Sbjct: 1727 MKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQ-------E 1779
Query: 1337 VLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK 1396
++ +LQQ+L+E R+ + K+ ++++ + R E ++E +Q + +
Sbjct: 1780 IV-----VLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEE 1834
Query: 1397 QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEM 1456
++KEK D LQ L++ + +K + +L E + L + + R+ LE
Sbjct: 1835 RVKEKADALQGALEQAHMTLKERHGELQDHKE-------QARRLEEELAVEGRRVQALEE 1887
Query: 1457 DIGKLKGEN-----------EKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMK- 1504
+G L+ E+ ++ E + E E +ALQ++ ++ +L+E++ E +++
Sbjct: 1888 VLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRA 1947
Query: 1505 ---------EKALAFEQLLKE-------KEQGKTGELNQLLNAVKSMQEKTVVFQQERDQ 1548
E A A + L+E QGK L + +S++ T Q D
Sbjct: 1948 ESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEASTATLQASLDA 2007
Query: 1549 VMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAK 1608
+Q + AL+ + ++D++ R +++++L+ L + ++ + ++RE
Sbjct: 2008 CQAHSRQLE---EALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQ----QEREQL 2060
Query: 1609 LRKKVT--VLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQ- 1665
L K + V E + N + + + +L + Q+++ L+L +Q++
Sbjct: 2061 LEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRN 2120
Query: 1666 -------------VKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENL 1712
+++ +L L +L+ L Q E A L + + EW++ A++L
Sbjct: 2121 NLEALPHSHKTSPMEEQSLKLDSLEPRL----QRELERLQAALRQTEAREIEWREKAQDL 2176
Query: 1713 EGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNEL 1756
+SL + ++ + A L Q V E E+ + Q+EL
Sbjct: 2177 ---ALSLAQTKASVSSLQEVAMFL--QASVLERDSEQQRLQDEL 2215
Score = 200 bits (509), Expect = 1e-50
Identities = 361/1732 (20%), Positives = 726/1732 (41%), Gaps = 298/1732 (17%)
Query: 35 KDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQST 94
K+++ ++ EL R++ + A R + ++ T LE++ A E ++ Q
Sbjct: 801 KEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLRE 860
Query: 95 SYRNQLQQKEVEISH----LKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGI 150
+ + + E++ L+ ++ L+ +L + Q+ +++ + T A S+
Sbjct: 861 KWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQREEERTQAESALC--- 917
Query: 151 SHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSE 210
Q ++ VS LE+ + QT K + D S Q E
Sbjct: 918 --------------------QMQLETEKERVSLLET-------LLQTQK-ELADASQQLE 949
Query: 211 ICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELEN 270
+ +++LK+ + I Q LQ A Q++L E +R+HR++L+ +E E +
Sbjct: 950 RLRQDMKVQKLKEQETTGILQTQ-----LQEA-QRELKEAARQHRDDLAALQE---ESSS 1000
Query: 271 LLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRD 330
LLQ + DL K E K+ V Q +S + +EQ ++ +KL
Sbjct: 1001 LLQD------KMDLQKQVEDLKSQLVAQ---DDSQRLVEQ------EVQEKL-------- 1037
Query: 331 ILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERIL----AQSASVEE 386
RE ++ N ++++ E +L L M +++R+L A S +E
Sbjct: 1038 ---RETQEYNRIQKELEREKASLTL-------------SLMEKEQRLLVLQEADSIRQQE 1081
Query: 387 VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEK---EELQM 443
+ L+Q + +A+ E LS+ + +R EV EKE L+QE EEL+
Sbjct: 1082 LSALRQDMQEAQGEQKELSAQME-----------LLRQEVKEKEADFLAQEAQLLEELEA 1130
Query: 444 SLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQ 503
S + + + + L L LEA E Q + A++ L
Sbjct: 1131 SHITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAE--QQPGNQAQAQAQLASLYSA 1188
Query: 504 NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEK------------------KRVHQ 545
Q+A + + +LS + S+ L+ D N + +H+
Sbjct: 1189 LQQALGSVCESRPELSGGGDSAPSVWG-LEPDQNGARSLFKRGPLLTALSAEAVASALHK 1247
Query: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNV----- 600
L D + DV ++++ + E L D K ++ ++++L QL+++QE
Sbjct: 1248 LHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGK 1307
Query: 601 --SIQKENLELKEHI-----RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653
S++ E +EL E + R EL R+ + + L Q + N ++ +A V
Sbjct: 1308 QNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENL-TAQVEHLQAAVVE 1366
Query: 654 LKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVR-------------HQLEECLAGN 700
+ S L E+L+ +K++NE++ E + L+E LA
Sbjct: 1367 ARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALL 1426
Query: 701 NQLSLEKNTIVETLKMEKGEIEAE----------LCWAKKRLLEEANKYEKTIEELSNAR 750
Q E+ VETL+ + E+E + L K+ +E + ++ I+EL R
Sbjct: 1427 TQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCR 1486
Query: 751 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLI 810
++ EHL Q+++ ++ ++ I +++ D + ++VL L E ++ Q+I
Sbjct: 1487 SV--------LEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMI 1538
Query: 811 NKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEEL- 869
+ ++ LK++ L+ + + K E ++ I+E + + + HL +L
Sbjct: 1539 ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLE 1598
Query: 870 ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQL 929
ER +E Q++++ + D ++ +V LA E+ + ++E+K ++ IE+ + K L
Sbjct: 1599 ERSQELQAQSSQIHDLESHSTV--LAREL-------QERDQEVKSQREQIEELQRQKEHL 1649
Query: 930 LQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTD 989
Q L+ + +E+ Q E++ Q + + K L++ +EQIK L E +++ T
Sbjct: 1650 TQDLERRDQEL---MLQKERIQVLEDQ----RTRQTKILEEDLEQIKLSLRERGRELTTQ 1702
Query: 990 NSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQL 1049
+ QE + G K E +L+ KE+E+E +
Sbjct: 1703 R-QLMQERAEEG----KGPSKAQRGSLEHMKLILRDKEKEVECQ---------------- 1741
Query: 1050 SKDEVGKLTQIIQQKDLEIQALHARISSTS-----HTQDVVYLQQQLQAYAMEREKVFAV 1104
++ + +L ++ Q + ++Q LH ++ TS Q++V LQQQLQ + E
Sbjct: 1742 -QEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGE----- 1795
Query: 1105 LNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSR 1164
L E++ L+++ + +A ++ L LQ E + ++ GQ+ R
Sbjct: 1796 LKEQS-----LQSQLDEAQRALAQRDQELEALQQEQQ------QAQGQE---------ER 1835
Query: 1165 IIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEW 1224
+ + D AL Q TL E G + E+ + ++L + +++
Sbjct: 1836 VKEKADALQGALEQAHMTL----------KERHGELQDHKEQARRLEEELAVEGRRV--- 1882
Query: 1225 KQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF 1284
Q + + +++ ES + ++ L LQ Q ++ + +V+ L S+ Q + LK
Sbjct: 1883 -QALEEVLGDLRAESREQEKALLALQQQC---AEQAQEHEVETRALQDSWLQAQAVLKER 1938
Query: 1285 GQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL 1344
QEL ++ + ++ + + + L A K + L E +E
Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALG--------KAHAALQGKEQHLLEQAE- 1989
Query: 1345 LQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDV 1404
L + LE +LQ A++ Q ++ +L ++ L +E E D +++ ++ Q +
Sbjct: 1990 LSRSLEASTATLQ---ASLDACQAHSRQLEEA------LRIQEGEIQDQDLRYQEDVQQL 2040
Query: 1405 LQKLL-KEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKG 1463
Q L ++++L + + +QLL ++ +V EN + Q NL + E + +++G
Sbjct: 2041 QQALAQRDEELRHQQEREQLL--EKSLAQRVQENMI--QEKQNLGQ-----EREEEEIRG 2091
Query: 1464 ENEKIVE---TYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQG 1520
++ + E T KE E L+ET + ++ + M+E++L + L E
Sbjct: 2092 LHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEEQSLKLDSL----EPR 2147
Query: 1521 KTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQE 1580
EL +L A++ + + + ++++ + L+L Q + ++LQ L+ + E
Sbjct: 2148 LQRELERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSE 2207
Query: 1581 LERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVES 1640
+RL++ L TR AL E +L +L S + V+ E
Sbjct: 2208 QQRLQDEL-----ELTRRALEKE----RLHSPGATSTAELGSRGEQGVQLGEVSGVEAEP 2258
Query: 1641 LQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQM--VLEHFQQEEKAM 1690
+ + S ++ LQ +V++ ++ + L N+Q+ LE ++E + +
Sbjct: 2259 SPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKL 2310
Score = 187 bits (475), Expect = 9e-47
Identities = 348/1644 (21%), Positives = 679/1644 (41%), Gaps = 270/1644 (16%)
Query: 263 ERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKL 322
ER +EL L QG DL K E+Q + L +S K+ E E IK + + +
Sbjct: 262 ERSQELIQLKSQG-------DLEKA-ELQDRVTELSALLTQSQKQNEDYEKMIKALRETV 313
Query: 323 SSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTE---KERILA 379
E + L + L+ R EE +L+ + V++ D + + E L
Sbjct: 314 EILETNHTELMEHEASLS---RNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENSLE 370
Query: 380 QSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMR-----IEVLEKEKSLL 434
+S+ F Q DA+ + + S+ A +L+ ++ + +L+++
Sbjct: 371 LDSSIFSQFDYQ----DADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQQQHDQW 426
Query: 435 SQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLI 494
+E + L+ L KL E + + A + + L E+ L +KE+EL Q +E L
Sbjct: 427 EEEGKALRQRLQKLTGERDTL---AGQTVDLQGEVDSL-----SKERELLQKA--REELR 476
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
++E L+ QEA + + + +L Q + + +++L+ + +L++ M +
Sbjct: 477 QQLEVLE---QEAWR-LRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLE 532
Query: 555 KELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIR 614
+ +LI AL HL + L + + L ++++S + LK +
Sbjct: 533 AKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVA 592
Query: 615 QNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFD 674
++ + L ++L D L Q L +LE+ N+++
Sbjct: 593 DLRAAAVKL-SALNEALALDKVG----------------LNQQLLQLEEENQSVCS---- 631
Query: 675 VKMENEKLVLACEDVRHQLEECLAG---NNQLSLEKNTIVETLKMEKGEIEAELCWAKKR 731
+ME A E R+ L+ LA + EKNT +E + E AEL +
Sbjct: 632 -RME------AAEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRD 684
Query: 732 LLEEANKYEKTIEELSNARNLNTSALQLEHEH-------LIKLNQKKDM---EIAELKKN 781
+ EE + +K + E + + T+ L+ H+ L + Q+K+ E A L+
Sbjct: 685 IQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVR 744
Query: 782 IEQMDTDHKE----------TKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEEL 831
++ ++ D ++ K++L SSL E +Q +I + +L+ ++
Sbjct: 745 LQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTK----------GQLEVQI 794
Query: 832 DKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSV 891
+QA ++ I+ + R L K E + + + E+ R+ +R A+ + ++
Sbjct: 795 QTVTQA-------KEVIQGEVRCL---KLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844
Query: 892 TEL-ASEVSQLNTIKEHLEEEIKHHQ----KIIEDQNQSKMQLLQSLQEQKKEMDEFRYQ 946
+ A+ ++N ++E E+E HQ K +E + KM+L L+EQ+ EM+ + Q
Sbjct: 845 EQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEAIQAQ 904
Query: 947 HE----QMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSL 1002
E Q + Q+ LE ++E SL +T+ Q + +L + Q ++ + Q+ KVQ L
Sbjct: 905 REEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLER----LRQDMKVQKL 960
Query: 1003 NIE--NGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
+ G + L +A+ E L + ++ ++ L E++ SL + L K +Q+
Sbjct: 961 KEQETTGILQTQLQEAQRE-LKEAARQHRDDLAALQEESSSLLQDKMDLQKQVEDLKSQL 1019
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHL---KT 1117
+ Q D + TQ+ +Q++L EREK L+ +E L +
Sbjct: 1020 VAQDDSQRLVEQEVQEKLRETQEYNRIQKEL-----EREKASLTLSLMEKEQRLLVLQEA 1074
Query: 1118 EYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS 1177
+ + ++ A ++ + + Q E K+LS + E Q++ K+ E D L+
Sbjct: 1075 DSIRQQELSALRQ-DMQEAQGEQKELSAQMELLRQEV--------------KEKEADFLA 1119
Query: 1178 QKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
Q+ Q L EEL E + +Q + W Q+ ++
Sbjct: 1120 QEAQLL---------------------EEL--EASHITEQQLRASLWAQEAKAAQLQLRL 1156
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
S + Q E + Q N ++ Q L + +Q ++G
Sbjct: 1157 RSTESQLEALAAEQQ----PGNQAQAQAQLASLYSA-----------------LQQALGS 1195
Query: 1298 LCNTKDLLLGKLDI------ISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEE 1351
+C ++ L G D + P + A L + L A +E ++ + L Q +
Sbjct: 1196 VCESRPELSGGGDSAPSVWGLEPDQNGARSLF-KRGPLLTALSAEAVASALHKLHQ---D 1251
Query: 1352 LRKSLQEKDATIRTLQENNHRLSDSIAATSELE------RKEHEQTDSEIKQLKEKQDVL 1405
L K+ Q +D +Q+ RL+D+ A S++ +++ Q E + + KQ+ L
Sbjct: 1252 LWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSL 1311
Query: 1406 QKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGEN 1465
+ L E + + +L + E ELL+ A NL ++ L+
Sbjct: 1312 ESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKENLTAQVEHLQ---------- 1361
Query: 1466 EKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEK-EQGKTGE 1524
+VE R + + L+E L+ K E S +E+A A ++ + K QGK +
Sbjct: 1362 AAVVEA-RAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELKVAQGKALQ 1420
Query: 1525 LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERL 1584
N L +++ E+ + R Q+ KQ++M+ AL+ L+ + NQE++
Sbjct: 1421 ENLAL-LTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLK----KRNQEVDLQ 1475
Query: 1585 RNHLLESEDSYT---REALAAEDREAKL---RKKVTVLEEKLVSSSNAMENASHQASVQV 1638
+ + E E + +A ++RE KL R+++ LE+ + N +E+ Q+
Sbjct: 1476 QEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEH-------QL 1528
Query: 1639 ESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLE--HFQQEEKAMYSAELE 1696
L+++ ++ QR + + +K+ ++L L + LE H + E + ELE
Sbjct: 1529 LELEKKDQMIESQRGQV--------QDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580
Query: 1697 KQKQ--------LIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIE 1748
Q++ L + ++ ++ L+ + + + + +++ + EQIE
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640
Query: 1749 ELKRQNELRQEMLDD------VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEV 1802
EL+RQ E + L+ +QK+ + + + K+L +L Q
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDL---------EQIKLS 1691
Query: 1803 LRLMGSILGVRREEMEQLFHDDQG 1826
LR G L +R+ M++ + +G
Sbjct: 1692 LRERGRELTTQRQLMQERAEEGKG 1715
Score = 128 bits (321), Expect = 6e-29
Identities = 252/1296 (19%), Positives = 508/1296 (39%), Gaps = 233/1296 (17%)
Query: 10 SGLGQSLGQVGGSLASLTGQISNFTKDMLMEG--TEEVEAELPDSRTK--EIEAIHAILR 65
SG G S V G G S F + L+ E V + L + + +LR
Sbjct: 1204 SGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDVLR 1263
Query: 66 SENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQ 125
+ ++L++ TD E A + Q+ + + QL Q + E S + +Q +L+ +L++L
Sbjct: 1264 DQVQKLEERLTDTE----AEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELH 1319
Query: 126 SAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLE 185
S+ S + +++ + +E L+ +V L+
Sbjct: 1320 ETMASLQSRL----------------RRAELQRMEAQGERELLQAAKE--NLTAQVEHLQ 1361
Query: 186 SEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQ 245
+ V R A + D KL+N E ++ R+Q + + Q E+ V Q Q
Sbjct: 1362 AAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQE-QGELKVAQGKALQ 1420
Query: 246 K----LTEISRRHREELSDYEERIEELENL--LQQGGSGVIETDLSKIYEMQKTIQVLQI 299
+ LT+ EE+ +I+ELE +Q+ ++ DL K + +Q QI
Sbjct: 1421 ENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKK-RNQEVDLQQEQI 1479
Query: 300 EKVESTKKM--------EQLEDKIKDINKKLSSAENDRDILRR--EQEQLNVEKRQIMEE 349
+++E + + ++ E K+ +++ E DR+ R E + L +EK+ M E
Sbjct: 1480 QELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQRNVLEHQLLELEKKDQMIE 1539
Query: 350 CEN----------LKLECSKL-----------QPSAVKQSDTMTEKERIL---------- 378
+ + LEC L Q +K+ + E +R+
Sbjct: 1540 SQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEE 1599
Query: 379 ------AQSASVEEVFR----LQQALSDAENEIM-----------RLSSLNQDNSLAEDN 417
AQS+ + ++ L + L + + E+ + L QD +
Sbjct: 1600 RSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQE 1659
Query: 418 LKL-KMRIEVLEKEKS----LLSQEKEELQMSLLKLNNEY-------------------- 452
L L K RI+VLE +++ +L ++ E++++SL + E
Sbjct: 1660 LMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGPSKA 1719
Query: 453 --------EVIKSTATRDISLDSE----LHDLRLNLEAKEQELNQSISEKETLIAEIEE- 499
++I +++ E L +L+ LE + Q L++ + E L+++ E+
Sbjct: 1720 QRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQREQE 1779
Query: 500 ---LDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKE 556
L +Q QEA + L + L Q +E +++ Q+L ++ Q + + + ++
Sbjct: 1780 IVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERVKEK 1839
Query: 557 LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616
D + L Q+ + L + H Q +++ L ++L ++++ +L+ R+
Sbjct: 1840 ADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAESREQ 1899
Query: 617 EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVK 676
E+ L ++ + + +E E E R L+ + + + V +
Sbjct: 1900 EKALLALQQQCAEQ-------------AQEHEVETRALQDSWLQAQ-------AVLKERD 1939
Query: 677 MENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736
E E L + RHQ E A E L+ G+ A L ++ LLE+A
Sbjct: 1940 QELEALRAESQSSRHQEEAARAR-----------AEALQEALGKAHAALQGKEQHLLEQA 1988
Query: 737 NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVL 796
ELS + +T+ LQ + +++ + + + I+ D ++E L
Sbjct: 1989 --------ELSRSLEASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQL 2040
Query: 797 SSSLEEQKQLTQLINKKEIFIEK-LKER-SSKLQEELDKYSQALRKNEI--LRQTIEEKD 852
+L ++ + + ++E +EK L +R + +E Q + EI L Q++ E
Sbjct: 2041 QQALAQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQ 2100
Query: 853 RSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
+L ++E+ LRE Q R A P + + + + +L++++ L+ E+
Sbjct: 2101 LTLAQK-------EQEILELRETQQRNNLEALPHS-HKTSPMEEQSLKLDSLEPRLQREL 2152
Query: 913 KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL---FLEKDEEIKSLQ 969
+ Q + +++ + Q+ + + + + L LE+D E + LQ
Sbjct: 2153 ERLQAALRQTEAREIEWREKAQDLALSLAQTKASVSSLQEVAMFLQASVLERDSEQQRLQ 2212
Query: 970 KTIEQIKTQLHEER---------QDIQTDNSDIFQETKVQSLNIE---NGSEKHDLSKAE 1017
+E + L +ER ++ + Q +V + E +G EK +
Sbjct: 2213 DELELTRRALEKERLHSPGATSTAELGSRGEQGVQLGEVSGVEAEPSPDGMEKQSW-RQR 2271
Query: 1018 TERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDE---VGKLTQIIQQKDLEIQALHAR 1074
E L + + E++ L N+ L ++Q+ ++ + + Q LEI ++
Sbjct: 2272 LEHLQQAVARLEIDRSRLQRHNVQLRSTLEQVERERRKLKREAMRAAQAGSLEI----SK 2327
Query: 1075 ISSTSHTQ-------------------DVVYLQQQLQAYAMEREKVFAVLNEKTRENSHL 1115
+++S TQ +VV LQ QL +++ + +RE + L
Sbjct: 2328 ATASSPTQQDGRGQKNSDAKCVAELQKEVVLLQAQLTLERKQKQDYITRSAQTSRELAGL 2387
Query: 1116 KTEY-HKMMDIVAAKEAALIKLQDENKKLSTRFESS 1150
H ++ + A EA + L+ E ++L S
Sbjct: 2388 HHSLSHSLLAVAQAPEATV--LEAETRRLDESLTQS 2421
Score = 127 bits (318), Expect = 1e-28
Identities = 240/1249 (19%), Positives = 523/1249 (41%), Gaps = 151/1249 (12%)
Query: 476 LEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMIL---IKDQLSKQQNEGDSIISKL 532
+E + LN + L+ E + L Q Q A +K+ QQ + +++ KL
Sbjct: 1 METRSPGLNNMKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQA-TLVRKL 59
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ + + +LE +++ T Q+ + ++ E L++L + ++ + + E+L +
Sbjct: 60 QAKVLQYRSWCQELEK-RLEATGGPIPQRWENVE-EPNLDELLVRLEEEQQRCESLAEVN 117
Query: 593 NKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ-DSNSNFKDTLLKEREAEV 651
+ + N L+E + + + SR R+ELM+ +Q F LK +
Sbjct: 118 TQLRLHMEKADVVNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRL 177
Query: 652 RNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV 711
+L + + + +K + + + L E VR L+G+ + T+
Sbjct: 178 LSLWREVVTFRRHFLEMKSAT-----DRDLMELKAEHVR------LSGSLLTCCLRLTVG 226
Query: 712 ETLKMEKGE--------IEAELCWAKKRLLE-EANKYEKTIEELSNARNLNTSALQ---L 759
+ G + L AK + LE EA++ + + +L + +L + LQ
Sbjct: 227 AQSREPNGSGRMDGREPAQLLLLLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVT 286
Query: 760 EHEHLIKLNQKKDME----IAELKKNIEQMDTDHKETKD---VLSSSLEEQKQLTQLINK 812
E L+ +QK++ + I L++ +E ++T+H E + LS + +E+K Q + K
Sbjct: 287 ELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIK 346
Query: 813 --KEIFIEK------------LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSM 858
++ +E+ E S + + D Y A + ++R + + +++ +
Sbjct: 347 DITQVMVEEGDNIAQGSGHENSLELDSSIFSQFD-YQDADKALTLVRSVLTRRRQAVQDL 405
Query: 859 KEENNHLQEELERLREEQSRTAPVADPKTL-DSVTELASEVSQLNTIKEHLEEEIKHHQK 917
+++ QE + L+++ + + K L + +L E L L+ E+ K
Sbjct: 406 RQQLAGCQEAVNLLQQQHDQWE--EEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSK 463
Query: 918 IIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKT 977
E +++ +L Q L+ ++E R + ++ +K+E+ + L + + +
Sbjct: 464 ERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE-RE 522
Query: 978 QLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNE 1037
+L E ++ S+ E +E+ + +L + E + + E I L+
Sbjct: 523 RLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSS 582
Query: 1038 KNISLTKQI--------------DQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQD 1083
+L ++ + L+ D+VG Q++Q ++ E Q++ +R+ + ++
Sbjct: 583 SENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEE-ENQSVCSRMEAAEQARN 641
Query: 1084 VVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKL 1143
LQ E EK L EK N+HL+ + K + A +A L +Q+E +++
Sbjct: 642 A------LQVDLAEAEKRREALWEK---NTHLEAQLQKAEEAGAELQADLRDIQEEKEEI 692
Query: 1144 STRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQ 1203
+ S T Q L ++ +E + + L++ Q +
Sbjct: 693 QKKLSESRHQQEAATTQ-LEQLHQEAKRQEEVLARAVQ---------------------E 730
Query: 1204 FEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKL 1263
E L++E+ L+ +++ +E +Q + +Q + L+ L + Q Q V +L
Sbjct: 731 KEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIEVTKGQL 790
Query: 1264 QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLT 1323
+V + Q+ E + +++ EL + Q + D + QL+ A
Sbjct: 791 EVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQ----------ERDAAARQLAQAEQEG 840
Query: 1324 PQSAECLRASKSEVLSESSELL-------QQELEELRKSLQEKDATIRTLQENNHRLSDS 1376
+ E +A+ + +++ E QQEL + +SL+ + + + ++
Sbjct: 841 KTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKMELEMRLKEQQTEMEA 900
Query: 1377 IAATSELERKEHEQT--DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV 1434
I A E ER + E +++ KE+ +L+ LL+ + L A S QL E +
Sbjct: 901 IQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADA-SQQL----ERLRQDM 955
Query: 1435 NENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLR 1494
+L Q T + + +L+ ++ E R + ALQE +
Sbjct: 956 KVQKLKEQETTGILQT---------QLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM 1006
Query: 1495 EKEFECHSMKEKALA---FEQLLKEKEQGK---TGELNQLLNAVKSMQEKTVVFQQERDQ 1548
+ + + +K + +A ++L++++ Q K T E N++ ++ + + E++Q
Sbjct: 1007 DLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQ 1066
Query: 1549 VMLALKQ----KQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESE-DSYTREALAAE 1603
+L L++ +Q E +AL+ ++Q + ++ + ++E LR + E E D +EA E
Sbjct: 1067 RLLVLQEADSIRQQELSALRQDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLE 1126
Query: 1604 DREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQR 1652
+ EA + E++L +S A E + Q +++ S + QL ++ ++
Sbjct: 1127 ELEAS-----HITEQQLRASLWAQEAKAAQLQLRLRSTESQLEALAAEQ 1170
Score = 62.4 bits (150), Expect = 4e-09
Identities = 97/429 (22%), Positives = 187/429 (43%), Gaps = 42/429 (9%)
Query: 1377 IAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV-- 1434
+A T ELE++ HE++ E+ QLK + D+ + L+++ + A Q NE++ +
Sbjct: 250 LAKTQELEKEAHERSQ-ELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNEDYEKMIKA 308
Query: 1435 --NENELLRQAVTNLKERILILEMDIGKLKGENEKIVE--TYRGKETEYQALQETNMKFS 1490
E+L T L E L + + K +++++ T E Q + + S
Sbjct: 309 LRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIAQGSGHENS 368
Query: 1491 MMLREKEFECHSMK--EKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQ 1548
+ L F + +KAL + + + + +L Q L QE + QQ+ D
Sbjct: 369 LELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQL---AGCQEAVNLLQQQHD- 424
Query: 1549 VMLALKQKQMENTALQNEVQRLR-DKEFRSNQELERLRNHLLESEDSYTREALAAEDREA 1607
Q + E AL+ +Q+L +++ + Q ++ L DS ++E +
Sbjct: 425 ------QWEEEGKALRQRLQKLTGERDTLAGQTVD-----LQGEVDSLSKERELLQKARE 473
Query: 1608 KLRKKVTVLEE---KLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQE 1664
+LR+++ VLE+ +L + ++ A Q E QE+L++ ++R+ L +
Sbjct: 474 ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEA 533
Query: 1665 QVKQYALSLANLQMVLE--HFQ----QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVIS 1718
+ + L L+ LE H + ++E+ +A L + +Q IAE + L+ +V
Sbjct: 534 KQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVAD 593
Query: 1719 LQ------ECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLA 1772
L+ L+EA ALD L +QL EE+ + + + E ++ + +Q L
Sbjct: 594 LRAAAVKLSALNEA-LALDKVG-LNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAE 651
Query: 1773 NSSEGKVDK 1781
E +K
Sbjct: 652 KRREALWEK 660
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 215 bits (547), Expect = 4e-55
Identities = 409/1896 (21%), Positives = 805/1896 (42%), Gaps = 317/1896 (16%)
Query: 29 QISNFTKDMLMEGTEEVEAELPDSRT--KEIEAIHAILRSENERLKKLCTDLEEKHEASE 86
Q+ + K M +G E E + R +E+E + + E +KL +++E+ + E
Sbjct: 386 QLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMDEQIKTIE 445
Query: 87 IQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSF 146
+++ S + +L + + E+ + + + ++Q+ KLQ +
Sbjct: 446 KTSEEERISLQQELSRVKQEVVDVMKK--SSEEQIAKLQKLHEK---------------- 487
Query: 147 AYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
++ +QE L+ ++ E E +A
Sbjct: 488 -------------------ELARKEQE---LTKKLQTREREFQEQMKVAL--------EK 517
Query: 207 DQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE 266
QSE K I +E +Q S +++ + + + + KL ++ ++E Y RI
Sbjct: 518 SQSEYLK---ISQEKEQQESLALEELELQKKAILTESENKLRDL----QQEAETYRTRIL 570
Query: 267 ELENLLQQGGSGVIETDLSKIYEMQKTIQV-LQIEKVESTKKMEQLEDKIKDINKKLSSA 325
ELE+ L E L + K + V L+ EK + K++ + +K K +L S
Sbjct: 571 ELESSL--------EKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHK---TELESL 619
Query: 326 ENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVE 385
++ +D L E+L V K+Q E E L+ +C ++ +T+ + + I+ Q+ E
Sbjct: 620 KHQQDAL--WTEKLQVLKQQYQTEMEKLREKCE-------QEKETLLKDKEIIFQAHIEE 670
Query: 386 EVFRLQQALSDAENEIMRLSS-----LNQDNSLAEDNLKLKMRIEVLEKE-KSLLSQEKE 439
+ + L + E+ LSS L + L E+ LK + + +++E ++ + ++K
Sbjct: 671 MNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKN 730
Query: 440 ELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE 499
Q + + E+EV S + +L +++ L L L+ +++ L + + E L A+I+
Sbjct: 731 HHQQQVDSIIKEHEV--SIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKR 788
Query: 500 LDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ------DLNDEK----KRVHQLEDD 549
+ + Q+A+ + + + S + + +L Q DL E+ K+V ++E
Sbjct: 789 SEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQ 848
Query: 550 KMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL-------VDQLNKSQE--SNV 600
K D+ ELD K IQ + + L ++E KV++L ++ NK QE +
Sbjct: 849 KKDVCTELDAHK---IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQI 905
Query: 601 SIQKEN--LELKEHIRQNEEELSR---IRNELMQSLNQDSNSNFKDTLLKEREAEVRNLK 655
++KEN L+++E ++ E L++ + + + LN++ + FK+ +E ++ +K
Sbjct: 906 LVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKN-----QEKKMEKVK 960
Query: 656 QNLSELEQLNENLKKVAFD------VKMENEKLVLACEDVRH--QLEECLAGNNQLSLEK 707
Q E++ E LKK D ++EN L L+ ++ + ++ E N+ +
Sbjct: 961 QKAKEMQ---ETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDA 1017
Query: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKL 767
+ +ET + E+ E E+ ++ L + + +EK LN A +L+ H I+L
Sbjct: 1018 VSRLETNQKEQIESLTEV--HRRELNDVISIWEK---------KLNQQAEELQEIHEIQL 1066
Query: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE-------QKQLTQLINKKEIFIEKL 820
Q+K+ E+AELK+ I + +E ++ EE +L + + +K + L
Sbjct: 1067 -QEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHVNSL 1125
Query: 821 KERSSKLQEELDK----YSQALRKNEILRQ------------------------TIEEKD 852
+ +KL+ L+K +++L++N L++ T +E+
Sbjct: 1126 AQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSKLKTTDEEF 1185
Query: 853 RSLGSMKEENNHLQE----ELERLREEQS--------RTAPVADPKTLDSVTELASEVSQ 900
+SL S E++N E E ++L EE + +T + + KT + + +S+ +
Sbjct: 1186 QSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALLEAKTNELINISSSKTNA 1245
Query: 901 LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLE 960
+ + H + ++ + + + +L L++ +E + +Q ATH E
Sbjct: 1246 ILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISFQQ--ATHQ--LEE 1301
Query: 961 KDEEIKSLQKTIEQIKTQLH-------EERQDIQTDNSDIFQETKVQSLNI--------- 1004
K+ +IKS++ IE + T+ ++Q S I Q K S NI
Sbjct: 1302 KENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENINAVTLMKEE 1361
Query: 1005 --ENGSEKHDLSKAETERLVK-----GIKERELEI----KLLNEKNISLTKQ-------I 1046
E E LSK T+ V+ + E+E I K +E+ L Q +
Sbjct: 1362 LKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKV 1421
Query: 1047 DQLSKDEVGKLTQIIQ-QKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER----EKV 1101
D LSK+++ L Q+ A+ T H V LQ QL+ + E E++
Sbjct: 1422 DTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQI 1481
Query: 1102 FAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--I 1159
+ E ++N +M D + E L+ E K + R + ++T I
Sbjct: 1482 NLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEI 1541
Query: 1160 QNLSRIIR----EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLK 1215
++L+ +++ +KDIE L QK Q E G N+ +E ++ L+
Sbjct: 1542 ESLNEVLKNYNQQKDIEHKELVQKLQHF----------QELGEEKDNRVKEAEEKILTLE 1591
Query: 1216 QQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA-QVLVDSDNNSKL----------- 1263
QV M K ++ T + ++H + ++ + +L+A + ++S++ +KL
Sbjct: 1592 NQVYSM---KAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQKI 1648
Query: 1264 -QVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLL 1322
+ L Q E+ E K L+++ + + +L KL + S +L+
Sbjct: 1649 AAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESS-QSETLI 1707
Query: 1323 TPQSAECLRASKSEVLSESSELLQQELEE----LRKSLQEKDATI-RTLQENNHRLSDSI 1377
P+SA+ + A + ++S +Q+ EE L+++L EK+ + R QE +S
Sbjct: 1708 VPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEETVSSHF 1767
Query: 1378 AATSELERKEHEQTDSEIKQLKEKQDV--LQKLLKEKD---LLIKAKSDQLLSSNENFTN 1432
+ + + + +E KQ +++ + LQ+ L+EK+ LI A+ + N
Sbjct: 1768 EMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQA 1827
Query: 1433 KVNENELLRQAVTNLKERIL---ILEMDIGKL-------KGENEKIVETYRGKETEYQAL 1482
K N + L+E+ L ILE I +L K + +E K + QAL
Sbjct: 1828 KQNLENVFDDVQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQAL 1887
Query: 1483 QETN--MKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK-- 1538
Q+ + K + +L E E K K+ + L + + +L L + ++K
Sbjct: 1888 QQMDGRNKPTELLEENTEE----KSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLG 1943
Query: 1539 TVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQE-LERLRNHLLESEDSYTR 1597
+ + ++D ML K+ Q E L+ E + R+++ + QE LE N L+
Sbjct: 1944 KEIVRLQKDLRMLR-KEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFN 2002
Query: 1598 EALAAEDREAKLRKKVTVLEEKLVSSS--NAMENASHQASVQVESLQEQLNVVSKQRDET 1655
LA +++E ++ K T+ + + V + + + ++Q ++ + L +K+ +E
Sbjct: 2003 TQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEE- 2061
Query: 1656 ALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGK 1715
+ + ++ + +LQ LE EL+K+ Q E ++N N
Sbjct: 2062 -----ILDAREEEMTAKVRDLQTQLE------------ELQKKYQQKLEQEENPGNDNVT 2104
Query: 1716 VISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
++ LQ L + L S S+L EQ EQI L+
Sbjct: 2105 IMELQTQLAQ-KTTLISDSKLKEQ--EFREQIHNLE 2137
Score = 214 bits (544), Expect = 9e-55
Identities = 330/1691 (19%), Positives = 738/1691 (43%), Gaps = 245/1691 (14%)
Query: 34 TKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIK-QQ 92
T+ + +E + E + +++K++ A+H L +E + K T + EKH+ +K QQ
Sbjct: 567 TRILELESSLEKSLQENKNQSKDL-AVH--LEAEKNKHNKEITVMVEKHKTELESLKHQQ 623
Query: 93 STSYRNQLQ----QKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAY 148
+ +LQ Q + E+ L+ + ++ LLK +
Sbjct: 624 DALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEII-------------------- 663
Query: 149 GISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQ 208
H ++ ++ D+ Q E+ LS+E+S EV RH + + D +D+
Sbjct: 664 -FQAHIEEMNEKTLEKLDV--KQTELESLSSELS----EVLKARHKLEEELSVLKDQTDK 716
Query: 209 SEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL 268
+ +EL+ ++ + HQ ++ + H+ + + +++++ E ++E
Sbjct: 717 MK--------QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKER 768
Query: 269 ENLLQQGGSGV--IETDLSK----IYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKL 322
+ L++ + V +E D+ + + + + V Q + + ++ + E+++ + +KL
Sbjct: 769 DKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKL 828
Query: 323 SSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQ-- 380
E +R +L ++ ++ +K+ + E + K++ L KQ+ M +K + L Q
Sbjct: 829 LDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVY 888
Query: 381 ----SASVEEVFRLQQALSDAENEIMRLSS--------LNQDNSLAEDNLKL-----KMR 423
+E + +Q L + EN I+++ L Q S ED++ + + +
Sbjct: 889 ESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETK 948
Query: 424 IEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQEL 483
+ EK+ + Q+ +E+Q +L K ++ L EL + L L KE++
Sbjct: 949 FKNQEKKMEKVKQKAKEMQETLKK---------KLLDQEAKLKKELENTALELSQKEKQF 999
Query: 484 N---------------QSISEKETLIAE-IEELDRQNQEATKHMILIKDQLSKQQNEGDS 527
N ++S ET E IE L ++ +I I ++ QQ E
Sbjct: 1000 NAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQ 1059
Query: 528 IISKLK-----QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL-------- 574
I +++ Q++ + K+++ +K ++ KE+ KE+ ++ + LN+L
Sbjct: 1060 EIHEIQLQEKEQEVAELKQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKS 1119
Query: 575 -HLT-----KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM 628
H+ + KL+ +E L LNKS + N +Q++ +ELK +++ ++S + ++
Sbjct: 1120 AHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK-- 1177
Query: 629 QSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED 688
LK + E ++LK S E+ N++L+ + + K +E+L + +
Sbjct: 1178 ---------------LKTTDEEFQSLK---SSHEKSNKSLEDKSLEFKKLSEELAIQLDI 1219
Query: 689 VRHQLEECL-AGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEE---ANKYEKTIE 744
+ E L A N+L ++ + + K+ LL + ++ E +
Sbjct: 1220 CCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLR 1279
Query: 745 ELSNARN-LNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQ 803
+L+ +N LN S Q H+ K NQ K M+ A+++ + + + KE + ++ E++
Sbjct: 1280 QLTEEQNTLNISFQQATHQLEEKENQIKSMK-ADIESLVTEKEALQKEGGNQQQAASEKE 1338
Query: 804 KQLTQL-------INKKEIFIEKLKERS---SKLQEELDKYSQALRKNEILRQTIEEKDR 853
+TQL IN + E+LKE+ S L ++L + L +N I ++ EK+
Sbjct: 1339 SCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQL-QNSI---SLSEKEA 1394
Query: 854 SLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIK 913
++ S++++ + + EL ++ S + + ++ ++ ++ + K+ +
Sbjct: 1395 AISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFT 1454
Query: 914 HHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973
HQ +++ + E+ ++++ + + +Q N L E +++ ++K
Sbjct: 1455 QHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKES 1514
Query: 974 QIKTQLHEERQDIQTDNSDIFQET-KVQSLN--IENGSEKHDLSKAETERLVKGI----K 1026
++T+L + I I Q+T +++SLN ++N +++ D+ E + ++ +
Sbjct: 1515 NLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGE 1574
Query: 1027 ERELEIKLLNEKNISLTKQIDQL------SKDEVGKLTQIIQQKDLEIQALHARISSTSH 1080
E++ +K EK ++L Q+ + K E+ + ++ K+ E++AL R+ S S
Sbjct: 1575 EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESA 1634
Query: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTRE-----NSHLKTEYHKMMDIVAAKEAALIK 1135
+ ++ Q A ++++ + + EK + SHL K+ + +E ++
Sbjct: 1635 AKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQE--REREVHIL- 1691
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC-QTLLAVLQTSSTGN 1194
E K S S + + +N++ +++ + QK + ++VLQ
Sbjct: 1692 ---EEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR----- 1743
Query: 1195 EAGGVNSNQFEELLQERDKLKQQ-VKKMEEWKQQVMTTVQNMQHESAQLQEE---LHQLQ 1250
N + E+LLQ + K++ V E + Q + ++H A+ E+ + LQ
Sbjct: 1744 -----NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQ 1798
Query: 1251 AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF--GQELAQVQHSIGQLCNTKDLLLGK 1308
++ + N K Y+ ++ + + E N Q L V + + K+L
Sbjct: 1799 EEL---EEKNKK----YSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQI 1851
Query: 1309 LDIISPQLSSASL------------LTPQSAECLRASKSEVLSESSELLQQELEELRKSL 1356
L+ +L S + LT + + + + ++ +ELL++ EE KS
Sbjct: 1852 LEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSH 1911
Query: 1357 QEKDATIRTLQENNHRLSDSIAATSELER---KEHEQTDSEIKQL-KEKQDVLQKLLKEK 1412
+ + ++ ++ L +A ++ KE + +++ L KE Q L+ L KE
Sbjct: 1912 LVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEY 1971
Query: 1413 DLLIKAKSDQLLSSNENFTNKVNE--NELLRQAVTNLKERILILEMDIGKLKGENEKIVE 1470
D + + +++ E+ K N +L+R+ T L ++ LEM I +
Sbjct: 1972 D---QEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKE---------T 2019
Query: 1471 TYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLN 1530
+ +E E + L+ + + +L++ + +K A +E++L +E+ T ++ L
Sbjct: 2020 INKAQEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQT 2079
Query: 1531 AVKSMQEKTVVFQQERDQ---------VMLALKQKQMENTALQNEVQRLRDKEFRSNQEL 1581
++ +Q+K +QQ+ +Q ++ L+ + + T L ++ +L+++EFR +++
Sbjct: 2080 QLEELQKK---YQQKLEQEENPGNDNVTIMELQTQLAQKTTLISD-SKLKEQEFR--EQI 2133
Query: 1582 ERLRNHLLESE 1592
L + L + E
Sbjct: 2134 HNLEDRLKKYE 2144
Score = 206 bits (523), Expect = 2e-52
Identities = 383/1887 (20%), Positives = 799/1887 (42%), Gaps = 315/1887 (16%)
Query: 26 LTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHA--ILRSENERLKKLCTDLEEK-- 81
L G + K+ L++ +E L R K E + A +L+ E ++L+ + + ++K
Sbjct: 127 LVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQMLQREKKKLQGILSQSQDKSL 186
Query: 82 ----HEASEIQIKQQSTSYRNQ-----LQQKEVEISHLKARQIALQDQLLKLQSAAQSVP 132
E+Q+ QQ+ + + L++K+ IS L+ Q++L Q +L++ +V
Sbjct: 187 RRIAELREELQMDQQAKKHLQEEFDASLEEKDQYISVLQT-QVSLLKQ--RLRNGPMNV- 242
Query: 133 SGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWR 192
D++ ++ + ++ E+
Sbjct: 243 ---------------------------------DVLKPLPQLEPQAEVFTKEENPESDGE 269
Query: 193 HIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISR 252
+ + + T + Q + + +N++K K+ I H+ + ++L T
Sbjct: 270 PVVEDGTSVKTLETLQQRVKRQENLLKRCKET----IQSHKEQCTLL--------TSEKE 317
Query: 253 RHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLE 312
+E+L +ER++ELE ++ + E TK + QL
Sbjct: 318 ALQEQL---DERLQELE-------------------------KIKDLHMAEKTKLITQL- 348
Query: 313 DKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMT 372
+D + E D+ ++ E KRQ+ E E + E ++L+ S +KQ T
Sbjct: 349 ---RDAKNLIEQLEQDKGMVIAET------KRQMHETLEMKEEEIAQLR-SRIKQMTTQG 398
Query: 373 EKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKS 432
E+ R + + L++ALS A Q A LK +M ++ EK+
Sbjct: 399 EELREQKEKSERAAFEELEKALSTA-----------QKTEEARRKLKAEMDEQIKTIEKT 447
Query: 433 LLSQEKEELQMSLLKLNNE-YEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKE 491
+E+ LQ L ++ E +V+K ++ I+ +LH+ L KEQEL + + +E
Sbjct: 448 -SEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHE--KELARKEQELTKKLQTRE 504
Query: 492 TLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKM 551
E +E + E ++ L Q +QQ S ++L +KK + ++K+
Sbjct: 505 ---REFQEQMKVALEKSQSEYLKISQEKEQQE------SLALEELELQKKAILTESENKL 555
Query: 552 -DITKELDVQKEKLIQSEVAL-NDLHLTKQKLEDKVENLVDQLNK-SQESNVSIQKENLE 608
D+ +E + + ++++ E +L L K + +D +L + NK ++E V ++K E
Sbjct: 556 RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTE 615
Query: 609 LKEHIRQNE----EELSRIRNELMQSLN--QDSNSNFKDTLLKEREAEVRNLKQNLSELE 662
L+ Q + E+L ++ + + ++ K+TLLK++E + + +E
Sbjct: 616 LESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ------AHIE 669
Query: 663 QLNE-NLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
++NE L+K+ DVK E + +L E L ++L E + + + K E+
Sbjct: 670 EMNEKTLEKL--DVKQTE------LESLSSELSEVLKARHKLEEELSVLKDQTDKMKQEL 721
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLN----TSALQLEHEHLIKLNQKKDMEIAE 777
EA ++ E+ N +++ ++ + ++ AL+ + L L +++D + E
Sbjct: 722 EA-------KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKE 774
Query: 778 LKKNIEQMDTD-------------------------HKETKDVLSSSLEEQKQLTQLINK 812
+ ++E ++ D H++TK + Q++L L +
Sbjct: 775 HQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETE 834
Query: 813 KEIFIEKLKERSSKLQE---ELDKY--------SQALRKNEILRQTIEEKDRSLGSMKEE 861
+ + +++ E ++ ++ ELD + Q ++N + Q ++ + S E+
Sbjct: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
Query: 862 NNHLQEELERL---REEQSRTAPVADPKTLDSVTE-LASEVSQLNTIKEHLEEEIKHHQK 917
N QE+ +++ +E K ++ +T+ L+++ ++ + E E + K+ +K
Sbjct: 895 GNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEK 954
Query: 918 IIEDQNQSKMQLLQSLQEQ--------KKEMD----EFRYQHEQMNATHTQLFLEKDEEI 965
+E Q ++ ++L+++ KKE++ E + +Q NA ++ I
Sbjct: 955 KMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGI 1014
Query: 966 KSLQKTI-----EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER 1020
+ EQI++ R+++ N I K + E E H++ E E+
Sbjct: 1015 SDAVSRLETNQKEQIESLTEVHRREL---NDVISIWEKKLNQQAEELQEIHEIQLQEKEQ 1071
Query: 1021 LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQ-QKDLEIQALHARISSTS 1079
V +K++ I L + + K+I L ++ V + T + + Q+ L+ ++ H S
Sbjct: 1072 EVAELKQK---ILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQEQLKQKSAHV----NS 1124
Query: 1080 HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDE 1139
QD L+ L EK+ LN+ +EN+ L+ + ++ + + + +L +
Sbjct: 1125 LAQDETKLKAHL-------EKLEVDLNKSLKENTFLQEQLVELKMLAEEDKRKVSELTSK 1177
Query: 1140 NKKLSTRFES--SGQDMFRETIQNLS----RIIREKDIEIDALSQKCQTLLAVLQTSSTG 1193
K F+S S + +++++ S ++ E I++D +K + LL +
Sbjct: 1178 LKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKTEALL-----EAKT 1232
Query: 1194 NEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQ--- 1250
NE ++S++ +L + + K++E TV ++ + QL EE + L
Sbjct: 1233 NELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEAQLRQLTEEQNTLNISF 1292
Query: 1251 ---AQVLVDSDNNSK-LQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL-------C 1299
L + +N K ++ D L+ E + + N Q ++ + I QL
Sbjct: 1293 QQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEKESCITQLKKELSENI 1352
Query: 1300 NTKDLLLGKLDIISPQLSSASL----LTPQSAECLRASKSE-VLSESSELLQQELEELRK 1354
N L+ +L ++SS S L Q + S+ E +S + +E EL
Sbjct: 1353 NAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLD 1412
Query: 1355 SLQEKDATIRTLQENN----HRLSDSIAATSELERKEHE---QTDSEIKQLKEKQDVLQK 1407
+Q+ + TL + ++ D SE ++K Q + +K+L+ + ++ K
Sbjct: 1413 QVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSK 1472
Query: 1408 LLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEK 1467
EKD I ++L N+ F E E + ++++ LE ++ +
Sbjct: 1473 EAYEKDEQINLLKEELDQQNKRFDCLKGEME---DDKSKMEKKESNLETELKSQTARIME 1529
Query: 1468 IVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQ 1527
+ + K E ++L E ++ ++K+ E + +K F++L +EK+ +
Sbjct: 1530 LEDHITQKTIEIESLNEVLKNYN---QQKDIEHKELVQKLQHFQELGEEKDNRVKEAEEK 1586
Query: 1528 LL---NAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQ-----RLRDKEFRSNQ 1579
+L N V SM+ + ++E + V L++K K+ E AL++ ++ +L + + ++ Q
Sbjct: 1587 ILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLAELKRKAEQ 1646
Query: 1580 ELERLRNHLL----ESEDSY---TREALAAEDREAKLR-KKVTVLEEKL--VSSSNAMEN 1629
++ ++ LL E E+ Y T L+ + + + R ++V +LEEKL V SS +
Sbjct: 1647 KIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKSVESSQSETL 1706
Query: 1630 ASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKA 1689
+++ V + EQ ++ D +E++ +L + +L+ QE++
Sbjct: 1707 IVPRSAKNVAAYTEQ-----EEADSQGCVQKTYEEKISVLQRNLTEKEKLLQRVGQEKEE 1761
Query: 1690 MYSAELEK----QKQLI----AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLD 1741
S+ E Q++LI AE K++ + + + LQE L+E N S + Q
Sbjct: 1762 TVSSHFEMRCQYQERLIKLEHAEAKQHED--QSMIGHLQEELEEKN---KKYSLIVAQHV 1816
Query: 1742 VKEEQIEELKRQNELRQEMLDDVQKKL 1768
KE ++ + L + + DDVQK L
Sbjct: 1817 EKEGGKNNIQAKQNL-ENVFDDVQKTL 1842
Score = 191 bits (484), Expect = 8e-48
Identities = 324/1533 (21%), Positives = 654/1533 (42%), Gaps = 205/1533 (13%)
Query: 343 KRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIM 402
K++I EE + L+ + Q S+ + T R+ ++++S E +L + + E+
Sbjct: 6 KQKISEEQQQLQQALAPAQASSNSSTPT-----RMRSRTSSFTE--QLDEGTPNRES--- 55
Query: 403 RLSSLNQDNSLAEDNLKLKMRIEVLE-------KEKSLLSQEKEEL-QMSLLKLNNEYEV 454
S A+ KL++R+ +E KE S KE L + S + N ++
Sbjct: 56 -----GDTQSFAQ---KLQLRVPSVESLFRSPIKESLFRSSSKESLVRTSSRESLNRLDL 107
Query: 455 IKSTATRD--ISLDSELHDL-----RLNLEAKEQELNQSISEKETLIAEIEELDRQNQEA 507
STA+ D +DSE DL LN E Q L + + + EL Q
Sbjct: 108 DSSTASFDPPSDMDSEAEDLVGNSDSLNKEQLIQRLRRMERSLSSYRGKYSELVTAYQML 167
Query: 508 TKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQS 567
+ ++ LS+ Q++ I++L+++L +++ L+++ D + E Q ++Q+
Sbjct: 168 QREKKKLQGILSQSQDKSLRRIAELREELQMDQQAKKHLQEE-FDASLEEKDQYISVLQT 226
Query: 568 EVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLE------------------L 609
+V+L L + V + QL E V ++EN E L
Sbjct: 227 QVSLLKQRLRNGPMNVDVLKPLPQLEPQAE--VFTKEENPESDGEPVVEDGTSVKTLETL 284
Query: 610 KEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLK 669
++ +++ E L R + + Q + L E+EA L + L ELE++
Sbjct: 285 QQRVKRQENLLKRCKETIQSHKEQCT------LLTSEKEALQEQLDERLQELEKIK---- 334
Query: 670 KVAFDVKM-ENEKLVLACEDVRHQLEECLAGNNQLSLE-KNTIVETLKMEKGEIEA---- 723
D+ M E KL+ D ++ +E+ + E K + ETL+M++ EI
Sbjct: 335 ----DLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSR 390
Query: 724 --ELCWAKKRLLEEANKYEKT-IEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
++ + L E+ K E+ EEL A S Q E KL + D +I ++K
Sbjct: 391 IKQMTTQGEELREQKEKSERAAFEELEKA----LSTAQKTEEARRKLKAEMDEQIKTIEK 446
Query: 781 NIEQ--------MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832
E+ + +E DV+ S EEQ Q +++KE+ K +E + KLQ
Sbjct: 447 TSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKEL-ARKEQELTKKLQTRER 505
Query: 833 KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVT 892
++ + ++ + + + + + KE+ L LE L ++ ++ K D
Sbjct: 506 EFQEQMK---VALEKSQSEYLKISQEKEQQESLA--LEELELQKKAILTESENKLRDLQQ 560
Query: 893 ELASEVSQLNTIKEHLEEEIKHHQKIIED--------QNQSKMQLLQSLQEQKKEMDEFR 944
E + +++ ++ LE+ ++ ++ +D +N+ ++ +++ K E++ +
Sbjct: 561 EAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLK 620
Query: 945 YQHEQMNATHTQLFLEKDEEIKSLQKT-IEQIKTQLHEERQDIQTDNSDIFQETKVQSLN 1003
+Q + L+ EK + +K +T +E+++ + +E++ + D IFQ ++ +N
Sbjct: 621 HQQDA-------LWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQ-AHIEEMN 672
Query: 1004 IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQ 1063
E EK D+ + E E L + E L+ + E+ +S+ K D+ K+ Q ++
Sbjct: 673 -EKTLEKLDVKQTELESLSSELSE-VLKARHKLEEELSVLK-------DQTDKMKQELEA 723
Query: 1064 KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMM 1123
K E + H + + + V +Q+ +A + ++ +L E+ + HLK +
Sbjct: 724 KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDK---HLKEHQAHVE 780
Query: 1124 DIVAAKEAALIKLQDENKKLST--RFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQ 1181
++ A + + +LQ + KL ++S+ + + + L+++ ++K ++++ +
Sbjct: 781 NLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQL-QQKLLDLET-----E 834
Query: 1182 TLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQ 1241
+L Q + + V + +Q +D ++Q K+ E +Q+V + Q + +
Sbjct: 835 RILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLED 894
Query: 1242 LQEELHQLQAQVLVDSDN----------------NSKLQVDYTGLIQSYEQNETKLKNFG 1285
+E Q + Q+LV+ +N KL + E+ ETK KN
Sbjct: 895 GNKEQEQTK-QILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQE 953
Query: 1286 QELAQVQHSIGQLCNT-KDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL 1344
+++ +V+ ++ T K LL + + +L + +L Q + A E+ +S
Sbjct: 954 KKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAG 1013
Query: 1345 LQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK--QLKEKQ 1402
+ + L + +E+ I +L E + R + + + E + + + EI QL+EK+
Sbjct: 1014 ISDAVSRLETNQKEQ---IESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKE 1070
Query: 1403 DVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLK 1462
+ +L K+K LL E E + + +T LKE + + + +L+
Sbjct: 1071 QEVAEL-KQKILLFGC-----------------EKEEMNKEITWLKEEGVKQDTTLNELQ 1112
Query: 1463 GENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECH-SMKEKALAFEQLLKEK---E 1518
E + K +L + K L + E + + S+KE EQL++ K E
Sbjct: 1113 -------EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKMLAE 1165
Query: 1519 QGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSN 1578
+ K ++++L + +K+ E+ + ++ +L+ K +E L E+ D +
Sbjct: 1166 EDKR-KVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKLSEELAIQLDICCKKT 1224
Query: 1579 QEL-ERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQ 1637
+ L E N L+ S T L+ R + + + T ++E L+ + + + Q
Sbjct: 1225 EALLEAKTNELINISSSKTNAILS---RISHCQHRTTKVKEALLIKTCTVS----ELEAQ 1277
Query: 1638 VESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK 1697
+ L E+ N ++ + QL + Q+K + +L E Q+E A EK
Sbjct: 1278 LRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKEGGNQQQAASEK 1337
Query: 1698 QKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDV----------KEEQI 1747
+ + K+ +EN+ V ++E L E + S S+ L+V KE I
Sbjct: 1338 ESCITQLKKELSENINA-VTLMKEELKEKKVEISSLSKQLTDLNVQLQNSISLSEKEAAI 1396
Query: 1748 EELKRQ-NELRQEMLDDVQKKLMSLANSSEGKV 1779
L++Q +E + E+LD VQ + S+ K+
Sbjct: 1397 SSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKI 1429
Score = 162 bits (411), Expect = 2e-39
Identities = 249/1266 (19%), Positives = 528/1266 (41%), Gaps = 130/1266 (10%)
Query: 550 KMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLEL 609
K I++E ++ L ++ + N T ++ + + +QL++ + S ++
Sbjct: 6 KQKISEEQQQLQQALAPAQASSNSS--TPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQ 63
Query: 610 KEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLK 669
K +R E S R+ + +SL + S+ K++L++ E L +L+ +
Sbjct: 64 KLQLRVPSVE-SLFRSPIKESLFRSSS---KESLVRTSSRE---------SLNRLDLDSS 110
Query: 670 KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAK 729
+FD D+ + E+ L GN+ SL K +++ L+
Sbjct: 111 TASFDPP----------SDMDSEAED-LVGNSD-SLNKEQLIQRLR-------------- 144
Query: 730 KRLLEEANKYEKTIEELSNARNLNTSALQLEHEHL---IKLNQKKDME-IAELKKNIEQM 785
R+ + Y EL A + LQ E + L + +Q K + IAEL++ ++
Sbjct: 145 -RMERSLSSYRGKYSELVTAYQM----LQREKKKLQGILSQSQDKSLRRIAELREELQMD 199
Query: 786 DTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILR 845
K ++ +SLEE+ Q ++ + +++ + L Q + E+
Sbjct: 200 QQAKKHLQEEFDASLEEKDQYISVLQTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVF- 258
Query: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVAD--PKTLDSVTELASEV-SQLN 902
T EE S G E+ + LE L++ R + +T+ S E + + S+
Sbjct: 259 -TKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKE 317
Query: 903 TIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKK-----EMDEFRYQHEQMNATHTQL 957
++E L+E ++ +KI + K +L+ L++ K E D+ E H L
Sbjct: 318 ALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETL 377
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAE 1017
+ K+EEI L+ I+Q+ TQ E R+ + F+E + + E KAE
Sbjct: 378 EM-KEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAE 436
Query: 1018 TERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISS 1077
+ +K I+ K E+ ISL +++ ++ ++ V + + +++ ++Q LH +
Sbjct: 437 MDEQIKTIE------KTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK--- 487
Query: 1078 TSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEA-ALIKL 1136
++ +Q+L RE+ F + E S ++EY K+ +E+ AL +L
Sbjct: 488 -----ELARKEQELTKKLQTREREFQEQMKVALEKS--QSEYLKISQEKEQQESLALEEL 540
Query: 1137 QDENKKLSTRFESSGQDMFRETIQNLSRIIR-EKDIEIDALSQKCQTLLAVLQTSSTGNE 1195
+ + K + T E+ +D+ +E +RI+ E +E K Q+ + + N+
Sbjct: 541 ELQKKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNK 600
Query: 1196 AGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV 1255
+ E+ E + LK Q + W +++ Q Q E +L+E+ Q + +L
Sbjct: 601 HNKEITVMVEKHKTELESLKHQQDAL--WTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658
Query: 1256 DSDNNSKLQVDYTG--LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIIS 1313
D + + ++ ++ + +T+L++ EL++V + +L +L + D +
Sbjct: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
Query: 1314 PQLSS----ASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQEN 1369
+L + Q + + + + + L+ ++ +L L+E+D ++ Q +
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778
Query: 1370 NHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNEN 1429
L I ++++ E++Q K DV Q KA +QL +
Sbjct: 779 VENLEADI-----------KRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQK 827
Query: 1430 FTNKVNENELLRQAVTNL--KERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNM 1487
+ E LL + V + +++ + E+D K++ ++ + E E Q ++
Sbjct: 828 LLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEME-QKVKSLTQ 886
Query: 1488 KFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQE-- 1545
+ L + E K+ + E ++ + +G+ E+ L + + ++ + +E
Sbjct: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYE 946
Query: 1546 ---RDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL-A 1601
++Q K KQ + ++L D+E + +ELE L + E + + L
Sbjct: 947 TKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEM 1006
Query: 1602 AEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQL-S 1660
A+ A + V+ LE +N E V L + +++ K+ ++ A +L
Sbjct: 1007 AQANSAGISDAVSRLE------TNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEELQE 1060
Query: 1661 VSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ 1720
+ + Q+++ +A L +++ ++ E E+ + I K+ + + LQ
Sbjct: 1061 IHEIQLQEKEQEVAEL--------KQKILLFGCEKEEMNKEITWLKEEGVKQDTTLNELQ 1112
Query: 1721 ECLDEANAALDS----ASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1776
E L + +A ++S ++L L+ E + + ++N QE L +L LA +
Sbjct: 1113 EQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQL----VELKMLAEEDK 1168
Query: 1777 GKVDKV 1782
KV ++
Sbjct: 1169 RKVSEL 1174
Score = 124 bits (312), Expect = 7e-28
Identities = 224/1061 (21%), Positives = 427/1061 (40%), Gaps = 173/1061 (16%)
Query: 801 EEQKQLTQLINKKEIFIE-----KLKERSSKLQEELDK------------YSQALRKN-- 841
EEQ+QL Q + + +++ R+S E+LD+ ++Q L+
Sbjct: 11 EEQQQLQQALAPAQASSNSSTPTRMRSRTSSFTEQLDEGTPNRESGDTQSFAQKLQLRVP 70
Query: 842 ---EILRQTIEEK-DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTE-LAS 896
+ R I+E RS +E L RL + S TA P +DS E L
Sbjct: 71 SVESLFRSPIKESLFRSSSKESLVRTSSRESLNRL-DLDSSTASFDPPSDMDSEAEDLVG 129
Query: 897 EVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQ 956
LN K QL+Q L+ ++ + +R ++ ++ +
Sbjct: 130 NSDSLN-----------------------KEQLIQRLRRMERSLSSYRGKYSELVTAYQM 166
Query: 957 LFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKA 1016
L EK + L ++ ++ ++ E R+++Q D Q+ K ++ E+ D S
Sbjct: 167 LQREKKKLQGILSQSQDKSLRRIAELREELQMD-----QQAK------KHLQEEFDASLE 215
Query: 1017 ETERLVKGIKERELEIKLLNEK------NISLTKQIDQL-------SKDEVG-------- 1055
E ++ + + + ++ LL ++ N+ + K + QL +K+E
Sbjct: 216 EKDQYISVL---QTQVSLLKQRLRNGPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVV 272
Query: 1056 ------KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKT 1109
K + +QQ+ + L R T + ++Q E+E + L+E+
Sbjct: 273 EDGTSVKTLETLQQRVKRQENLLKRCKETIQSH-----KEQCTLLTSEKEALQEQLDERL 327
Query: 1110 RENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREK 1169
+E K+ D+ A++ LI + K L + E + ET + + + K
Sbjct: 328 QE-------LEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMK 380
Query: 1170 DIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWK---- 1225
+ EI L + + Q ++ G E +E +K +K EE +
Sbjct: 381 EEEIAQLRSR------IKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLK 434
Query: 1226 ----QQVMTTVQNMQHESAQLQEELHQLQAQVL-----VDSDNNSKLQVDYTGLIQSYEQ 1276
+Q+ T + + E LQ+EL +++ +V+ + +KLQ + + EQ
Sbjct: 435 AEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELARKEQ 494
Query: 1277 NETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSE 1336
TK + Q Q + + + L K+ Q S +L E L K
Sbjct: 495 ELTKKLQTREREFQEQMKVALEKSQSEYL--KISQEKEQQESLAL------EELELQKKA 546
Query: 1337 VLSESSELL---QQELEELRKSLQEKDATI-RTLQENNHRLSDSIAATSELERKEHEQTD 1392
+L+ES L QQE E R + E ++++ ++LQEN ++ D +A E E+ +H +
Sbjct: 547 ILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKD-LAVHLEAEKNKHNK-- 603
Query: 1393 SEIKQLKEKQDV-LQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERI 1451
EI + EK L+ L ++D L K L + K+ E + ++ T LK++
Sbjct: 604 -EITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLRE-KCEQEKETLLKDKE 661
Query: 1452 LILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFE 1511
+I + I ++ NEK +E K+TE ++L + + E E +K++ +
Sbjct: 662 IIFQAHIEEM---NEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718
Query: 1512 QLLKEK-EQGKTGELNQLLNAVK----SMQEKTVVFQQERDQVMLALKQKQMENTALQNE 1566
Q L+ K ++ K Q+ + +K S+Q + + +Q+ L LK++ Q
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAH 778
Query: 1567 VQRLRDKEFRSNQELERLRNHL--LESEDSYTREALAA-EDREAKLRKKVTVLEEKLVSS 1623
V+ L RS EL++ L +S S T E A E++ A+L++K+ LE + +
Sbjct: 779 VENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERIL- 837
Query: 1624 SNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHF 1683
L +Q+ V Q+ + +L + QV+ L +E
Sbjct: 838 -----------------LTKQVAEVEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQK 880
Query: 1684 QQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVK 1743
+ +Y ++LE + + K+ E ++ ++E LT++L K
Sbjct: 881 VKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMRE------GQKKEIEILTQKLSAK 934
Query: 1744 EEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLM 1784
E+ I L + E + + + +K+ A + + K L+
Sbjct: 935 EDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLL 975
>gi|114155142 nuclear pore complex-associated protein TPR [Homo
sapiens]
Length = 2363
Score = 202 bits (515), Expect = 2e-51
Identities = 344/1655 (20%), Positives = 718/1655 (43%), Gaps = 261/1655 (15%)
Query: 301 KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL 360
KVES ++ ++E ++ ++L + + LR E E+LN + + + E +N +LE ++
Sbjct: 47 KVESEQQYFEIEKRLSHSQERLVNETRECQSLRLELEKLNNQLKALTE--KNKELEIAQD 104
Query: 361 QPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKL 420
+ A++ T T++E + + RL Q L ++ RL+ ++++ + L+L
Sbjct: 105 RNIAIQSQFTRTKEELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQL 164
Query: 421 KM------RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL----DSELH 470
K+ + V +EK L QEKE L LN E +K+ ++L +E+
Sbjct: 165 KLDELQASDVSVKYREKR-LEQEKELLHSQNTWLNTE---LKTKTDELLALGREKGNEIL 220
Query: 471 DLRLNLEAK-------EQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQN 523
+L+ NLE K E+++N + E L +E+L + +EA + ++++ + N
Sbjct: 221 ELKCNLENKKEEVSRLEEQMNGLKTSNEHLQKHVEDLLTKLKEAKEQQASMEEKFHNELN 280
Query: 524 EGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKE--KLIQS---EVALNDLHLTK 578
+ + K +D + + ++L ++ K L E K IQ EV + + K
Sbjct: 281 AHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSKDQMEK 340
Query: 579 Q------KLEDKVENLVDQLNKSQESNVSIQKENLE------------LKEHIRQNEEEL 620
+ +LE ++EN D L+ ++ + +E L +K ++ E
Sbjct: 341 EMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYN 400
Query: 621 SRIRNE---LMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKM 677
+ + + L++ L + + D ++KE EA+ LK+ E E+ + + + VK+
Sbjct: 401 AYVETQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAV--ASLSVKL 458
Query: 678 ENEKLVLACEDVRHQLEECLAGNNQLS-LEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736
E A ++++ E+ N Q S LE++ ++++ ++ ++ L E
Sbjct: 459 EQ-----AMKEIQRLQEDTDKANKQSSVLERDN--RRMEIQVKDLSQQIRVLLMELEEAR 511
Query: 737 NKYEKTIEELSNARNLNTSALQLEH----EHLIKLNQKKDMEIAELKKNIEQMDTDHKET 792
+ EE+S+A ++S + +H ++ +L Q+ + L++ E + + +ET
Sbjct: 512 GNHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQET 571
Query: 793 KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKD 852
++T+L K E + +L++ Q ++ +R+ ++ R + +
Sbjct: 572 ---------TSSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTT 622
Query: 853 R---SLGSMKEENNHLQEELERLREEQ--SRTAPVADPKTLDSVTELASEVSQLNTIKEH 907
L + ++ L +R Q S APV ++ +++ E + + QL I E+
Sbjct: 623 GVAIPLHASSLDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAI-EAKAALKQLQEIFEN 681
Query: 908 LEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL-FLEKDEEIK 966
++E ++KI +Q L+ LQEQ + + R Q+ +++ TQL F K E+
Sbjct: 682 YKKEKAENEKIQNEQ-------LEKLQEQ---VTDLRSQNTKIS---TQLDFASKRYEM- 727
Query: 967 SLQKTIEQIK---TQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
LQ +E + T LHE Q + Q + ++ +EK +++ E L
Sbjct: 728 -LQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENLK- 785
Query: 1024 GIKEREL----EIKLLNEKNISLTKQIDQ-LSKDEVGKLTQIIQQKDLEI-QALHARISS 1077
KE+E+ E++L ++ L +Q Q L + + I+++ + E Q L ++I
Sbjct: 786 --KEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQIEK 843
Query: 1078 TSHTQDVVYLQQQL-----QAYAMEREKVFAVLNEK----TRENSHLKTEYHKMMDIVAA 1128
H ++ +L+++L Q + + R +L+ K T N HL T K + A
Sbjct: 844 LEH--EISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNT---KELLKNAQ 898
Query: 1129 KEAALIKLQDENKKLSTRFESS-----GQDMFRETIQNLSRIIREKDIEIDALSQKCQTL 1183
KE A +K N ++ +SS GQ +E + +L +R+ + +++ L ++
Sbjct: 899 KEIATLKQHLSNMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQTEEQVNDLKER---- 954
Query: 1184 LAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQ 1243
L+TS++ N Q++ ++ L++ + K ++ ++V ++ ESA+ Q
Sbjct: 955 ---LKTSTS-------NVEQYQAMV---TSLEESLNKEKQVTEEVRKNIEVRLKESAEFQ 1001
Query: 1244 EELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKD 1303
QL+ +++ +LQ D I+S EQ ++LK + L+ VQ+ + +
Sbjct: 1002 T---QLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELK---KTLSSVQNEVQEALQRAS 1055
Query: 1304 LLL-------------GKLDIISPQLSSASL-LTPQSAECLRASKSEV---------LSE 1340
L K+ + + L L E L+A+K +V L E
Sbjct: 1056 TALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEE 1115
Query: 1341 SSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKE---HEQ----TDS 1393
+++ + +L E + S +E++ ++ +S + +LE++ H+Q +D
Sbjct: 1116 TTQKAESQLLECKASWEERERMLK------DEVSKCVCRCEDLEKQNRLLHDQIEKLSDK 1169
Query: 1394 EIKQLKE-KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNL----- 1447
+ +KE Q L L E + KS + + F + E R V +
Sbjct: 1170 VVASVKEGVQGPLNVSLSE-----EGKSQEQILEILRFIRREKEIAETRFEVAQVESLRY 1224
Query: 1448 KERILILEMDIGKLK----GENEKIVETYRGKETEYQALQETN-----MKFSMMLR---- 1494
++R+ +LE ++ +L+ E EK+ T + + +++T M+ + MLR
Sbjct: 1225 RQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKE 1284
Query: 1495 --EKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLA 1552
E++ + K + L + L ++ + E + +L A K + E+ V + R+Q +++
Sbjct: 1285 RLEQDLQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHLVS 1344
Query: 1553 -------------LKQKQMENTALQ---NEVQRLRDKEFRSNQELERLRNHLLESEDSYT 1596
L +K++ +Q E+ RL+ + RSN L +N + ++
Sbjct: 1345 QQKDPDTEEYRKLLSEKEVHTKRIQQLTEEIGRLKAEIARSNASLTNNQNLIQSLKEDLN 1404
Query: 1597 REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
+ E + L K+ ++EK V + ++ + Q E L+ Q + V ET+
Sbjct: 1405 KVRTEKETIQKDLDAKIIDIQEK-VKTITQVKKIGRRYKTQYEELKAQQDKVM----ETS 1459
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKV 1716
Q S ++ + L+ L + + K++ S ++E ++ ++E + A NL+ +
Sbjct: 1460 AQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLES-QVENLQKTLSEKETEARNLQEQT 1518
Query: 1717 ISLQECLDEANAALDSAS----RLTEQLDVKEEQI------------------------- 1747
+ LQ L L + +L +Q+ KEE+
Sbjct: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKEN 1578
Query: 1748 EELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
EELK++N + D++ ++ +L + EG++ ++
Sbjct: 1579 EELKQRNGALDQQKDELDVRITALKSQYEGRISRL 1613
Score = 172 bits (436), Expect = 3e-42
Identities = 344/1695 (20%), Positives = 689/1695 (40%), Gaps = 300/1695 (17%)
Query: 43 EEVEAELPD------SRTKEIEAIHAILRSENERLKKLCTDLEEKH-EASEIQIKQQSTS 95
EE+EAE D ++E+E + ++ NE+LK+ T E + E+Q S
Sbjct: 118 EELEAEKRDLIRTNERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDELQASDVSVK 177
Query: 96 YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155
YR + ++E E+ H ++ L +L T A G
Sbjct: 178 YREKRLEQEKELLH--SQNTWLNTEL-----------------KTKTDELLALGREKG-- 216
Query: 156 AFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQ 215
+I+ + + EVSRLE ++ G S++ ++
Sbjct: 217 ---------NEILELKCNLENKKEEVSRLEEQMN------------GLKTSNEHLQKHVE 255
Query: 216 NIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEER-------IEEL 268
+++ +LK+ + Q+ + + L NAH ++S ++ D E + +EEL
Sbjct: 256 DLLTKLKEAKEQQASMEEKFHNEL-NAH----IKLSNLYKSAADDSEAKSNELTRAVEEL 310
Query: 269 ENLLQQGGSG--VIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAE 326
LL++ G I+ L ++ + + Q+EK E +K+ +LE ++++ N LS+ +
Sbjct: 311 HKLLKEAGEANKAIQDHLLEVEQSKD-----QMEK-EMLEKIGRLEKELENANDLLSATK 364
Query: 327 NDRDILRREQ--------------------------EQLNVEKRQIMEECENLKLECSKL 360
IL E+ + + + ++E+ EN ++ +K
Sbjct: 365 RKGAILSEEELAAMSPTAAAVAKIVKPGMKLTELYNAYVETQDQLLLEKLENKRI--NKY 422
Query: 361 QPSAVKQSDTMT------EKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLA 414
VK+ + +E AQ A +L+QA+ + + N+ +S+
Sbjct: 423 LDEIVKEVEAKAPILKRQREEYERAQKAVASLSVKLEQAMKEIQRLQEDTDKANKQSSVL 482
Query: 415 E-DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473
E DN +++++++ L ++ +L E EE + + + + E ++ DIS SE+
Sbjct: 483 ERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIRDEE------VSSADISSSSEVISQH 536
Query: 474 LNLEAKEQELNQSISEKETLIAEIEEL----DRQNQEATKHMILIKDQLSKQQNEGDSII 529
L +EL Q + + L+ + EL +R+ QE T ++++ Q + +S +
Sbjct: 537 LVSYRNIEELQQ---QNQRLLVALRELGETREREEQETTS------SKITELQLKLESAL 587
Query: 530 SKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHL------------- 576
++L+Q L ++ QL D I ++ D+ + L Q+ LH
Sbjct: 588 TELEQ-LRKSRQHQMQLVDS---IVRQRDMYRILLSQTTGVAIPLHASSLDDVSLASTPK 643
Query: 577 ---TKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ 633
T Q + V + ++ E+ ++ K+ E+ E+ ++ + E +I+NE ++ L +
Sbjct: 644 RPSTSQTVSTPAPVPVIESTEAIEAKAAL-KQLQEIFENYKKEKAENEKIQNEQLEKLQE 702
Query: 634 D----SNSNFK-----DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL 684
+ N K D K E N++ E+ L+E +K+ + + + +
Sbjct: 703 QVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINT 762
Query: 685 ACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI---EAELCWAKKRLLEEANKYEK 741
+D+R G N+ E LK EK + E L ++ LL E
Sbjct: 763 MTQDLR--------GANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQNL 814
Query: 742 TIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIE-QMDTDHKETKDVLSSSL 800
+ L + + + + L +K + EI+ LKK +E +++ H T+++ L
Sbjct: 815 LLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLENEVEQRHTLTRNLDVQLL 874
Query: 801 EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEI--LRQTIEEKDRSLGSM 858
+ ++QL N KE Q+E+ Q L E+ Q+ + + S
Sbjct: 875 DTKRQLDTETNLHL----NTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSN 930
Query: 859 KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI 918
KE+ + L +L + E+ V D K + + S V Q + LEE + +++
Sbjct: 931 KEDVDDLVSQLRQTEEQ------VNDLK--ERLKTSTSNVEQYQAMVTSLEESLNKEKQV 982
Query: 919 IEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQ 978
E+ + ++++ + KE EF+ Q E+ ++ EK E ++ IE ++ Q
Sbjct: 983 TEE-------VRKNIEVRLKESAEFQTQLEKKLM---EVEKEKQELQDDKRRAIESMEQQ 1032
Query: 979 LHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEK 1038
L E ++ + + +++ + + S + N + + + + V+ + E E+ +L+
Sbjct: 1033 LSELKKTLSSVQNEVQEALQRASTALSNEQQARRDCQEQAKIAVEAQNKYEREL-MLHAA 1091
Query: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMER 1098
++ Q +K++V K+ + Q + Q +++ + + ++ + E
Sbjct: 1092 DVEAL----QAAKEQVSKMASVRQHLEETTQKAESQLLECKASWE-----ERERMLKDEV 1142
Query: 1099 EKVFAVLNEKTRENSHLKTEYHKMMDIVAA--KEAALIKLQDENKKLSTRFESSGQDMFR 1156
K + ++N L + K+ D V A KE L N LS +S Q
Sbjct: 1143 SKCVCRCEDLEKQNRLLHDQIEKLSDKVVASVKEGVQGPL---NVSLSEEGKSQEQ---- 1195
Query: 1157 ETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQ 1216
++ L I REK+I +T V Q S + Q ELL+ +L++
Sbjct: 1196 -ILEILRFIRREKEI--------AETRFEVAQVES-------LRYRQRVELLER--ELQE 1237
Query: 1217 QVKKMEEWKQQVMTTVQNM-QHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYE 1275
+ +++V T + M QHE EL + + V + N L+ + L Q +
Sbjct: 1238 LQDSLNAEREKVQVTAKTMAQHE------ELMKKTETMNVVMETNKMLREEKERLEQDLQ 1291
Query: 1276 QNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKS 1335
Q + K++ ++ +Q + +L S L + L + + +A
Sbjct: 1292 QMQAKVRKLELDILPLQEANAELSEK-----------SGMLQAEKKLLEEDVKRWKARNQ 1340
Query: 1336 EVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSE- 1394
++S+ + + EE RK L EK+ + +Q+ + +E+ R T+++
Sbjct: 1341 HLVSQQKD---PDTEEYRKLLSEKEVHTKRIQQLTEEIG---RLKAEIARSNASLTNNQN 1394
Query: 1395 -IKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILI 1453
I+ LKE L K+ EK+ + K +++ E ++ R+ T +E
Sbjct: 1395 LIQSLKED---LNKVRTEKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEE---- 1447
Query: 1454 LEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQL 1513
LK + +K++ET ++Q E+ M+E
Sbjct: 1448 -------LKAQQDKVMETSAQSSGDHQ--------------EQHVSVQEMQE-------- 1478
Query: 1514 LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLR-D 1572
LKE LNQ KS++ + Q+ + + Q + LQ+E+ RLR D
Sbjct: 1479 LKET-------LNQAETKSKSLESQVENLQKTLSEKETEARNLQEQTVQLQSELSRLRQD 1531
Query: 1573 KEFRSNQELERLRNHLLESEDSYTREALAAEDREAKL---RKKVTVLEEKLVSSSNAMEN 1629
+ R+ QE E+LR + E E+ + +AA+ + A L + ++T E+L + A++
Sbjct: 1532 LQDRTTQE-EQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKENEELKQRNGALDQ 1590
Query: 1630 ASHQASVQVESLQEQ 1644
+ V++ +L+ Q
Sbjct: 1591 QKDELDVRITALKSQ 1605
Score = 138 bits (347), Expect = 6e-32
Identities = 193/1002 (19%), Positives = 416/1002 (41%), Gaps = 115/1002 (11%)
Query: 61 HAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQ-----KEVEISHLKARQI 115
+ +L+ E ++ T L E+++ ++Q Q +++ ++ ++A +
Sbjct: 725 YEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQDLRGANEKLAVAEVRAENL 784
Query: 116 ALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEIN 175
+ ++LKL S + + + + + + +SSQ I
Sbjct: 785 KKEKEMLKLSEVRLSQQRESLLAEQRGQNLLLTNLQTIQGILERSETETKQRLSSQ--IE 842
Query: 176 RLSNEVS----RLESEVGHWRHIAQTSKAQGTDNSDQSEI-CKLQNIIKELKQNRSQEID 230
+L +E+S +LE+EV + + Q D Q + L KEL +N +EI
Sbjct: 843 KLEHEISHLKKKLENEVEQRHTLTRNLDVQLLDTKRQLDTETNLHLNTKELLKNAQKEIA 902
Query: 231 DHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM 290
+ +S N Q ++ S+R + +E +++L + L+Q E ++ + E
Sbjct: 903 TLKQHLS---NMEVQVASQSSQRTGKGQPSNKEDVDDLVSQLRQ-----TEEQVNDLKER 954
Query: 291 QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEEC 350
KT ST +EQ + + + + L+ + + +R+ E E + +
Sbjct: 955 LKT----------STSNVEQYQAMVTSLEESLNKEKQVTEEVRKNIEVRLKESAEFQTQL 1004
Query: 351 ENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMR------- 403
E +E K ++ + +K R + + +++ L++ LS +NE+
Sbjct: 1005 EKKLMEVEK------EKQELQDDKRRAI--ESMEQQLSELKKTLSSVQNEVQEALQRAST 1056
Query: 404 -LSSLNQDNSLAEDNLKLKMRIE-VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATR 461
LS+ Q ++ K+ + + E+E L + + E LQ + +++ V +
Sbjct: 1057 ALSNEQQARRDCQEQAKIAVEAQNKYERELMLHAADVEALQAAKEQVSKMASVRQHLEET 1116
Query: 462 DISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQ 521
+S+L + + + E +E+ L +S+ + E+L++QN+ + + D++
Sbjct: 1117 TQKAESQLLECKASWEERERMLKDEVSK---CVCRCEDLEKQNRLLHDQIEKLSDKVVAS 1173
Query: 522 QNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581
EG + L L++E K Q+ + I +E ++ + + ++V + L
Sbjct: 1174 VKEG--VQGPLNVSLSEEGKSQEQILEILRFIRREKEIAETRFEVAQVESLRYRQRVELL 1231
Query: 582 EDKVENLVDQLNKSQE-----SNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSN 636
E +++ L D LN +E + Q E L K E +++ E + L QD
Sbjct: 1232 ERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETMNVVMETNKMLREEKERLEQD-- 1289
Query: 637 SNFKDTLLKEREAEVRNLKQNLSELEQLNENL-----------KKVAFDVKM---ENEKL 682
L++ +A+VR L+ ++ L++ N L K + DVK N+ L
Sbjct: 1290 -------LQQMQAKVRKLELDILPLQEANAELSEKSGMLQAEKKLLEEDVKRWKARNQHL 1342
Query: 683 VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKT 742
V +D + L ++ ++ ++ L E G ++AE+ + L N +
Sbjct: 1343 VSQQKDPDTEEYRKLLSEKEVHTKR---IQQLTEEIGRLKAEIARSNASLTNNQNLIQSL 1399
Query: 743 IEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEE 802
E+L+ R +Q + + I Q+K I ++KK + T ++E K +E
Sbjct: 1400 KEDLNKVRT-EKETIQKDLDAKIIDIQEKVKTITQVKKIGRRYKTQYEELKAQQDKVMET 1458
Query: 803 QKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEEN 862
Q + ++ + +++++E L + K + E L++T+ EK+ +++E+
Sbjct: 1459 SAQSSGDHQEQHVSVQEMQELKETLNQAETKSKSLESQVENLQKTLSEKETEARNLQEQT 1518
Query: 863 NHLQEELERLREE-QSRTA---------PVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
LQ EL RLR++ Q RT + KT ++ S+++ L +K+ L +E
Sbjct: 1519 VQLQSELSRLRQDLQDRTTQEEQLRQQITEKEEKTRKAIVAAKSKIAHLAGVKDQLTKE- 1577
Query: 913 KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTI 972
N+ Q +L +QK E+D T L + + I L++ +
Sbjct: 1578 ----------NEELKQRNGALDQQKDELD----------VRITALKSQYEGRISRLEREL 1617
Query: 973 EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLS 1014
+ + + E+R + Q ++ + ++ + +L S + ++
Sbjct: 1618 REHQERHLEQRDEPQEPSNKVPEQQRQITLKTTPASGERGIA 1659
Score = 100 bits (250), Expect = 1e-20
Identities = 189/952 (19%), Positives = 406/952 (42%), Gaps = 120/952 (12%)
Query: 890 SVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQ 949
+V + E ++LN + + ++ ++ +K + DQ QS++ L+ E+ K E +Y +
Sbjct: 3 AVLQQVLERTELNKLPKSVQNKL---EKFLADQ-QSEIDGLKGRHEKFKVESEQQYFEIE 58
Query: 950 MNATHTQ-LFLEKDEEIKSLQKTIEQIKTQLH---EERQDIQ-TDNSDIFQETKVQSLNI 1004
+H+Q + + E +SL+ +E++ QL E+ ++++ + +I +++
Sbjct: 59 KRLSHSQERLVNETRECQSLRLELEKLNNQLKALTEKNKELEIAQDRNIAIQSQFTRTKE 118
Query: 1005 ENGSEKHDLSKAETERLVKGIKERELEIKLLNEK--NISLTKQIDQLSKDEVGKLTQIIQ 1062
E +EK DL + ERL + ++ ++K LNEK + TK QL DE +Q
Sbjct: 119 ELEAEKRDLIRTN-ERLSQELEYLTEDVKRLNEKLKESNTTKGELQLKLDE-------LQ 170
Query: 1063 QKDLEIQALHARISSTS---HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEY 1119
D+ ++ R+ H+Q+ +L +L+ + +++ A+ EK E LK
Sbjct: 171 ASDVSVKYREKRLEQEKELLHSQNT-WLNTELKT---KTDELLALGREKGNEILELKCNL 226
Query: 1120 HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQK 1179
+ V+ E + L+ N+ L E L+++ K+ + +
Sbjct: 227 ENKKEEVSRLEEQMNGLKTSNEHLQKHVEDL-----------LTKLKEAKEQQASMEEKF 275
Query: 1180 CQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHES 1239
L A ++ S+ A + + EL + ++L + +K+ E + + + ++
Sbjct: 276 HNELNAHIKLSNLYKSAADDSEAKSNELTRAVEELHKLLKEAGEANKAIQDHLLEVEQSK 335
Query: 1240 AQLQEELHQLQAQVLVDSDNNSKL--QVDYTGLIQSYEQNET---------KLKNFGQEL 1288
Q+++E+ + ++ + +N + L G I S E+ K+ G +L
Sbjct: 336 DQMEKEMLEKIGRLEKELENANDLLSATKRKGAILSEEELAAMSPTAAAVAKIVKPGMKL 395
Query: 1289 AQVQHSIGQLCNTKD-LLLGKLD----------IISPQLSSASLLTPQSAECLRASKSEV 1337
++ ++ + T+D LLL KL+ I+ + A +L Q E RA K+
Sbjct: 396 TELYNAYVE---TQDQLLLEKLENKRINKYLDEIVKEVEAKAPILKRQREEYERAQKAVA 452
Query: 1338 -LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS--------ELE--RK 1386
LS E +E++ L++ + + L+ +N R+ + S ELE R
Sbjct: 453 SLSVKLEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARG 512
Query: 1387 EHEQTDSEIKQL---KEKQDVLQKLLKEKDLL-IKAKSDQLLSSNENF--TNKVNENELL 1440
H D E+ + + Q L+ +++ ++ ++ +LL + T + E E
Sbjct: 513 NHVIRDEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETT 572
Query: 1441 RQAVTNLKERILILEMDIGKLKGENE---KIVETYRGKETEYQALQETNMKFSMMLREKE 1497
+T L+ ++ ++ +L+ + ++V++ + Y+ L ++ L
Sbjct: 573 SSKITELQLKLESALTELEQLRKSRQHQMQLVDSIVRQRDMYRILLSQTTGVAIPLHASS 632
Query: 1498 FECHSMKE--KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQ 1555
+ S+ K + Q + E + + A ++++ +F+ + + K
Sbjct: 633 LDDVSLASTPKRPSTSQTVSTPAPVPVIESTEAIEAKAALKQLQEIFENYKKEKAENEKI 692
Query: 1556 KQMENTALQNEVQRLRDKEFRSNQELE---RLRNHLLESEDSYTREALAAEDREAKLRKK 1612
+ + LQ +V LR + + + +L+ + L ++ + Y RE + +R KL
Sbjct: 693 QNEQLEKLQEQVTDLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTAT 752
Query: 1613 VTVLEEKLVSSSNAMENASHQ---ASVQVESLQEQLNVVSKQRDETALQL-SVSQEQVKQ 1668
E+ + + + + A+ + A V+ E+L+++ ++ + Q S+ EQ Q
Sbjct: 753 TQKQEQIINTMTQDLRGANEKLAVAEVRAENLKKEKEMLKLSEVRLSQQRESLLAEQRGQ 812
Query: 1669 YAL--SLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEA 1726
L +L +Q +LE + E K S+++EK + I+ KK EN
Sbjct: 813 NLLLTNLQTIQGILERSETETKQRLSSQIEKLEHEISHLKKKLEN--------------- 857
Query: 1727 NAALDSASRLTEQLDVKEEQIEELKRQNELR-------QEMLDDVQKKLMSL 1771
++ LT LDV Q+ + KRQ + +E+L + QK++ +L
Sbjct: 858 --EVEQRHTLTRNLDV---QLLDTKRQLDTETNLHLNTKELLKNAQKEIATL 904
>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
Length = 1411
Score = 198 bits (504), Expect = 4e-50
Identities = 301/1390 (21%), Positives = 605/1390 (43%), Gaps = 137/1390 (9%)
Query: 129 QSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFG-----DIISSQQEINRLSNEVSR 183
+S G P S A + H A HD D G ++ + ++ L EV
Sbjct: 35 ESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQD 94
Query: 184 LESEVGHWRHIAQT-----SKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHE--- 235
L++ + + ++ K QG + + + EL Q+ Q++++ Q E
Sbjct: 95 LQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAEL-QSLEQQLEEAQTENFN 153
Query: 236 MSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQ 295
+ +++ +QK +++ E++D + + +E +L + V T L++ E+ K
Sbjct: 154 IKQMKDLFEQKAAQLAT----EIADIKSKYDEERSLREAAEQKV--TRLTE--ELNKEAT 205
Query: 296 VLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKL 355
V+Q K E ++ +ED + + K+L + D + E+E+ E E LK
Sbjct: 206 VIQDLKTELLQR-PGIED-VAVLKKELVQVQTLMDNMTLERER----------ESEKLKD 253
Query: 356 ECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAE 415
EC KLQ T+++ LA+ +EV Q L ++ + L+ NQ +L E
Sbjct: 254 ECKKLQSQYASSEATISQLRSELAKGP--QEVAVYVQELQKLKSSVNELTQKNQ--TLTE 309
Query: 416 DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLN 475
+ LK + LE++ + S K+ +Q +L + + + + ++S + ++ LH + +
Sbjct: 310 NLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSAS---ETSLHRIHVE 366
Query: 476 LEAK---EQELNQSISEKET----LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI 528
L K Q+L + +SE ET L AE ++L +Q +E +H + QL + N+ S
Sbjct: 367 LSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGL----QLQSEINQLHSK 422
Query: 529 ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL 588
+ + ++ L + R+ + + + EKL+ E + DL L +LE++++
Sbjct: 423 LLETERQLGEAHGRLKE----------QRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEK 472
Query: 589 VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKERE 648
V + Q ++++ E + + +L +N+L Q L Q + KD ++ E
Sbjct: 473 VTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGD---KDQKIQNLE 529
Query: 649 AEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL-ACEDVRHQLEECLAG-----NNQ 702
A ++ K+N+S LE+ E+L A E E VL ++ H L+E + NQ
Sbjct: 530 ALLQKSKENISLLEKEREDL--YAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQ 587
Query: 703 LSLEKNTIVETLKMEKGEIEAELCWAKKRLLE---EANKYEKTIEELSNARNLNTSALQL 759
K E L + E +A L A+ R+L N+ + E + ++
Sbjct: 588 SESHKQA-QENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKA 646
Query: 760 EHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK 819
+ E L+ K + A+L+ +++ ++ + L+ + Q+T + K+ E
Sbjct: 647 KTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQ---EH 703
Query: 820 LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRT 879
+ S L+E +KY +K E L I++ + +K ++L++ R+ +
Sbjct: 704 CSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDL 763
Query: 880 APVAD--PKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQK 937
A K L+ E+ S K E IK E++ Q Q ++L ++
Sbjct: 764 ELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQET 823
Query: 938 KEMDEFRYQHEQMN----ATHTQLFLEKDE------EIKSLQKTIEQIKTQLHEERQDIQ 987
K QHE++N T T+L K E E+ +++ + ++ L + + +
Sbjct: 824 K------IQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFE 877
Query: 988 TDNSDIFQETKVQSLNIENGSE--KHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQ 1045
+N Q+ K L++E + KH L + + E +K +++EL+ L EK S +
Sbjct: 878 KEN----QKGKAAILDLEKTCKELKHQL-QVQMENTLK--EQKELKKSLEKEKEASHQLK 930
Query: 1046 IDQLS-KDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAV 1104
++ S ++++ + ++Q + E Q L I+ + + Q++ Q A++ E AV
Sbjct: 931 LELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE----QKKKQIEALQGELKIAV 986
Query: 1105 LNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSR 1164
L +KT + L+ + + +AA++ + LQ+ +K F+ D + + L+
Sbjct: 987 L-QKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLAT 1045
Query: 1165 IIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEW 1224
K +E + LS + L+ S N+ G N +EL + L+Q K E+
Sbjct: 1046 RQDLKSVE-EKLSLAQEDLI------SNRNQIGNQN-KLIQELKTAKATLEQDSAKKEQQ 1097
Query: 1225 KQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF 1284
Q+ +Q++Q E + ++EL ++++ + + + + T L + E KL++
Sbjct: 1098 LQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKL--NEELKSHKLESI 1155
Query: 1285 GQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSEL 1344
+E+ ++ + L K L GK D S Q + K +V E EL
Sbjct: 1156 -KEITNLKDAKQLLIQQKLELQGKAD-------SLKAAVEQEKRNQQILKDQVKKEEEEL 1207
Query: 1345 LQQELE---ELRKSLQEKDATIRTLQENNHRLSDSIAATSE---LERKEHEQTDSEIKQL 1398
++ +E +L ++EK+ ++ +EN +L+ I A +E +KE + + + +L
Sbjct: 1208 KKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSEL 1267
Query: 1399 KEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDI 1458
+++ D L+ + + ++ D+ + E E E L+ V L+ ++ +
Sbjct: 1268 EKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAV 1327
Query: 1459 GKLKGENEKI 1468
+L EN+ +
Sbjct: 1328 QELGRENQSL 1337
Score = 176 bits (445), Expect = 3e-43
Identities = 266/1305 (20%), Positives = 549/1305 (42%), Gaps = 191/1305 (14%)
Query: 67 ENERLKKLCTDLEEKHEASEIQIKQQSTS----------YRNQLQQKEVEISHLKARQIA 116
E+E+LK C L+ ++ +SE I Q + Y +LQ+ + ++ L +
Sbjct: 247 ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQT 306
Query: 117 LQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINR 176
L + LLK + + + + + A H D+D QQ +R
Sbjct: 307 LTENLLKKEQDYTKLEEKHNEESVSKKNIQA--------TLHQKDLD------CQQLQSR 352
Query: 177 LSNEVSRLESEVGHWRHIAQTSKAQGTDN--SDQSEI-CKLQNIIKELKQNRSQEIDDHQ 233
LS + L H H+ + K + T + SE+ K Q++ E KQ + Q + Q
Sbjct: 353 LSASETSL-----HRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQ 407
Query: 234 HEMSVLQNAHQ--QKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQ 291
H + + +Q KL E R+ E +E+ + L V + L K+ ++
Sbjct: 408 HGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQL-KLSRLE 466
Query: 292 KTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDI-LRREQEQLNVEKRQIMEEC 350
+ ++ EKV ++ +++ DK K +++ + + LR Q L RQI ++
Sbjct: 467 EQLK----EKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKD 522
Query: 351 ENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQD 410
+ ++ + LQ S K++ ++ EKER E+++ QA E E L+ L +
Sbjct: 523 QKIQNLEALLQKS--KENISLLEKER--------EDLYAKIQA---GEGETAVLNQLQEK 569
Query: 411 NSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELH 470
N ++ + ++ EK K+ K+ + ++ + +++ R +SL++ ++
Sbjct: 570 NHTLQEQVT-----QLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVN 624
Query: 471 DLRLNLEAKEQELNQ---SISEKETLIAEIEELDR-QNQEATKHMILIKDQLSKQQNEGD 526
+L L +++++Q I K L+ E Q + H+ ++ L +Q E +
Sbjct: 625 ELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELN 684
Query: 527 SIISKLKQ---DLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLED 583
I ++L Q L D+++ QLE + ++ ++K + E + L +++
Sbjct: 685 KITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKA 744
Query: 584 KVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTL 643
E + L + ++ N ++ EL + + +E +S R +L + ++ + K L
Sbjct: 745 SKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKK--SEALESIKQKL 802
Query: 644 LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQL 703
K+ E E + LKQ+ L Q + K+++E+L NN++
Sbjct: 803 TKQEE-EKQILKQDFETLSQ----------ETKIQHEEL-----------------NNRI 834
Query: 704 SLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEH 763
T ++ +KMEK + EL K +L K + L N+++ E E
Sbjct: 835 QTTV-TELQKVKMEKEALMTELSTVKDKL-------SKVSDSLKNSKS--------EFE- 877
Query: 764 LIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKER 823
K NQK I +L+K +++ + + + ++L+EQK+L + + K++ +LK
Sbjct: 878 --KENQKGKAAILDLEKTCKELK---HQLQVQMENTLKEQKELKKSLEKEKEASHQLKLE 932
Query: 824 SSKLQEELDKYSQALRKNEI----LRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRT 879
+ +QE+L + L++NE L+ I E +S K++ LQ EL+ +++
Sbjct: 933 LNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTEL 992
Query: 880 APVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKE 939
+ + ELA+E +++ ++ + E+ + +++ D + +LL + Q+ K
Sbjct: 993 ENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSV 1052
Query: 940 MDEFRYQHEQMNATHTQLFLEKD--EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQET 997
++ E + + Q+ + +E+K+ + T+EQ + ++ Q+ DI +E
Sbjct: 1053 EEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEK 1112
Query: 998 KVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKL 1057
++ + N EK L++ E EIK EK I TK ++L ++ +
Sbjct: 1113 SLKEKELVN--EKSKLAEIE-------------EIKCRQEKEI--TKLNEELKSHKLESI 1155
Query: 1058 TQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKT 1117
+I KD + + ++ + +Q E+ + ++ +E LK
Sbjct: 1156 KEITNLKDAKQLLIQQKLELQGKADSLKAAVEQ------EKRNQQILKDQVKKEEEELKK 1209
Query: 1118 EY----HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDM--FRETIQNLSRIIREKDI 1171
E+ K+ + KE + K ++ KL+ + + +++ ++ Q+ R + E +
Sbjct: 1210 EFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEK 1269
Query: 1172 EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTT 1231
+ D L + +AVL+ + N+ ER L ++ K E
Sbjct: 1270 QTDDLRGE----IAVLEATVQNNQ-------------DERRALLERCLKGEG-------E 1305
Query: 1232 VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNF-----GQ 1286
++ +Q + +LQ +L A V N LQ+ +T + + +++N G
Sbjct: 1306 IEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGF 1365
Query: 1287 ELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLR 1331
+ +H Q N I + S+ + LTP S + +R
Sbjct: 1366 SVTVRRHHCRQCGN----------IFCAECSAKNALTPSSKKPVR 1400
Score = 174 bits (442), Expect = 6e-43
Identities = 287/1399 (20%), Positives = 605/1399 (43%), Gaps = 226/1399 (16%)
Query: 459 ATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQL 518
A D DS H NL K ++ E + L A ++E ++E K + + L
Sbjct: 62 AVHDAGNDSG-HGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG-L 119
Query: 519 SKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTK 578
+Q+ + D +++ +L ++++ + + + +I + D+ ++K Q + D+ K
Sbjct: 120 QQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADI---K 176
Query: 579 QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSN 638
K +++ L ++ E V+ L E + + + ++ EL+Q +
Sbjct: 177 SKYDEE-----RSLREAAEQKVT------RLTEELNKEATVIQDLKTELLQRPGIE---- 221
Query: 639 FKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLA 698
+V LK+ L +++ L +N+ + + E+EKL C+ ++ Q A
Sbjct: 222 -----------DVAVLKKELVQVQTLMDNM---TLERERESEKLKDECKKLQSQYASSEA 267
Query: 699 GNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+QL E + KG E + ++E K + ++ EL+ T L
Sbjct: 268 TISQLRSE---------LAKGPQEVAV------YVQELQKLKSSVNELTQKNQTLTENLL 312
Query: 759 LEHEHLIKLNQKKDMEIAELKKNIE----QMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ + KL +K + E KKNI+ Q D D ++ + LS+S ++ +++K
Sbjct: 313 KKEQDYTKLEEKHNEESVS-KKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKG 371
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEEL----- 869
+KLKE S+++ KY + + L+Q EEK++ ++ E N L +L
Sbjct: 372 EATQKLKEELSEVET---KYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETER 428
Query: 870 ------ERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQN 923
RL+E++ ++ K +D ++A +L+ ++E L+E++ + ++ +
Sbjct: 429 QLGEAHGRLKEQRQ----LSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLD 484
Query: 924 QSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQ---LH 980
++K Q + Q+ + R + Q+ +KD++I++L+ +++ K L
Sbjct: 485 KTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIG-DKDQKIQNLEALLQKSKENISLLE 543
Query: 981 EERQDI-----------------QTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
+ER+D+ Q N + ++ + ++N SE H K E L
Sbjct: 544 KEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESH---KQAQENLHD 600
Query: 1024 GIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQA-----LHARISST 1078
++E++ ++ ++ +SL +++L+ ++ + + + Q D++I+A L A + T
Sbjct: 601 QVQEQKAHLRAAQDRVLSLETSVNELNS-QLNESKEKVSQLDIQIKAKTELLLSAEAAKT 659
Query: 1079 SHTQDVVY-----------LQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVA 1127
+ D+ QQ+L + ++V A L +K S L++ + +
Sbjct: 660 AQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYL 719
Query: 1128 AKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVL 1187
+ E +L+ + KKL E+ ++ Q L + +++ + D L + L L
Sbjct: 720 SLEQKTEELEGQIKKL----EADSLEVKASKEQALQDLQQQRQLNTD-LELRATELSKQL 774
Query: 1188 QTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELH 1247
+ + ++ + E L+ +KQ++ K EE KQ + + + E+ EEL
Sbjct: 775 EMEKEIVSSTRLDLQKKSEALES---IKQKLTKQEEEKQILKQDFETLSQETKIQHEEL- 830
Query: 1248 QLQAQVLVDSDNNSKLQVDYTGLIQSYEQNE---TKLKNFGQELAQVQHSIGQLCNT--K 1302
N+++Q T L + + E T+L +L++V S+ + K
Sbjct: 831 ------------NNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEK 878
Query: 1303 DLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ-EKDA 1361
+ GK I+ + + L L E +E +EL+KSL+ EK+A
Sbjct: 879 ENQKGKAAILDLEKTCKEL-------------KHQLQVQMENTLKEQKELKKSLEKEKEA 925
Query: 1362 TIRTLQENNHRLSDSIAATSELER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAK 1419
+ + E N I A + L++ KE +Q I +LK+ + +K ++ +K
Sbjct: 926 SHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIA 985
Query: 1420 SDQLLSSNENFTNKVNENELLRQAVTNL---KERILILEMDIGKLKGENEKIVETYRGKE 1476
+L E NK+ + L QA L KE+I +L+ + K + +++ + G+E
Sbjct: 986 ---VLQKTE-LENKLQQQ--LTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRE 1039
Query: 1477 TEYQALQETNMKFSMMLREKEFECHSMKEK-ALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
+E A ++ + S++EK +LA E L+ + NQ+ N K +
Sbjct: 1040 SELLATRQ--------------DLKSVEEKLSLAQEDLISNR--------NQIGNQNKLI 1077
Query: 1536 QE-KTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDS 1594
QE KT E+D A K++Q++ R K + Q+ + L+ L +E S
Sbjct: 1078 QELKTAKATLEQDS---AKKEQQLQE----------RCKALQDIQKEKSLKEKELVNEKS 1124
Query: 1595 YTREALAAEDREAKLRKKVTVLEEKLVSSS-NAMENASHQASVQVESLQEQLNVVSKQRD 1653
E E+ + + K++T L E+L S +++ ++ + +Q++L + K
Sbjct: 1125 KLAEI---EEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKA-- 1179
Query: 1654 ETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLE 1713
+L+ +V QE+ N Q++ + ++EE+ + +EK+ +L +E K+ ++
Sbjct: 1180 -DSLKAAVEQEK--------RNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMK 1230
Query: 1714 GKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQ-NELRQEML---------DD 1763
+ + + A ++ + ++ + ++ EL++Q ++LR E+ D
Sbjct: 1231 KHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQD 1290
Query: 1764 VQKKLMSLANSSEGKVDKV 1782
++ L+ EG+++K+
Sbjct: 1291 ERRALLERCLKGEGEIEKL 1309
Score = 134 bits (336), Expect = 1e-30
Identities = 174/879 (19%), Positives = 392/879 (44%), Gaps = 89/879 (10%)
Query: 43 EEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQ 102
E+V ++ D + ++I+ + A+L+ E + L + E+ + ++IQ + T+ NQLQ+
Sbjct: 512 EQVLRQIGD-KDQKIQNLEALLQKSKENISLLEKEREDLY--AKIQAGEGETAVLNQLQE 568
Query: 103 KEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDM 162
K +H Q+ + LK QS + A H A D +
Sbjct: 569 K----NHTLQEQVTQLTEKLKNQSESHK-------QAQENLHDQVQEQKAHLRAAQDRVL 617
Query: 163 DFGDIISS-QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGT-DNSD-QSEICKLQNIIK 219
++ ++N +VS+L+ ++ + +++A T +D Q+ + QN ++
Sbjct: 618 SLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ 677
Query: 220 ELKQNRSQEIDDHQHEMSVLQNA--HQQKLTEISRRHREELSDYEERIEELENLLQQGGS 277
+ +Q ++ + LQ+ H +L + ++E+ E++ EELE +++ +
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737
Query: 278 GVIETDLSKIYEMQKTIQVLQIE---KVESTKKMEQLE-----------------DKIKD 317
+E SK +Q Q Q+ ++ +T+ +QLE + ++
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797
Query: 318 INKKLSSAENDRDILRREQEQLNVEKRQIMEECEN-LKLECSKLQPSAVKQSDTMTEKER 376
I +KL+ E ++ IL+++ E L+ E + EE N ++ ++LQ +++ MTE
Sbjct: 798 IKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELST 857
Query: 377 ILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKE----KS 432
+ + + V + + ++ + EN+ + + L+ + + E +L++++E KE K
Sbjct: 858 VKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKK 917
Query: 433 LLSQEKEELQMSLLKLNNEYE-------VIKSTATRDISLDSELHDLRLNLEAKEQELNQ 485
L +EKE L+LN+ E +K + L +++L+ + E K++++
Sbjct: 918 SLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEA 977
Query: 486 SISEKETLIAEIEELDRQNQE----ATKHMILIKDQLSKQQN---EGDSIISKLKQDLND 538
E + + + EL+ + Q+ A + + K+++S QN + +L+ D
Sbjct: 978 LQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYG 1037
Query: 539 EKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQES 598
+ + D + ++L + +E LI + + + + Q+L+ +
Sbjct: 1038 RESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKT--------------A 1083
Query: 599 NVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNL 658
++++++ + ++ +++ + L I+ E +SL + N K L + E + R K
Sbjct: 1084 KATLEQDSAKKEQQLQERCKALQDIQKE--KSLKEKELVNEKSKLAEIEEIKCRQEK--- 1138
Query: 659 SELEQLNENLK-------KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV 711
E+ +LNE LK K ++K + L+ +++ + + A Q + +
Sbjct: 1139 -EITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILK 1197
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYE---KTIEELSNARNLNTSALQLEHEHLIKLN 768
+ +K E+ E++ E + +L E + E K EE + +AL + K
Sbjct: 1198 DQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEW 1257
Query: 769 QKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQ 828
Q ++EL+K + + + + + ++ +E++ L + K E IEKL+ + +LQ
Sbjct: 1258 QSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQ 1317
Query: 829 EELDKYSQALRKNEILRQTIEEK-DRSLGSMKEENNHLQ 866
+LD + A+++ Q+++ K ++L E+N +Q
Sbjct: 1318 RKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQ 1356
Score = 90.5 bits (223), Expect = 1e-17
Identities = 127/617 (20%), Positives = 249/617 (40%), Gaps = 56/617 (9%)
Query: 1193 GNEAG-GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA 1251
GN++G G SN L +RD V + + Q + +++ + S +L++EL + Q
Sbjct: 67 GNDSGHGGESN----LALKRD----DVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQG 118
Query: 1252 QVLVDSDNNSKLQVDYTGLIQSYEQN--ETKLKNFG--QELAQVQHSIGQLCNTKDLLLG 1307
++ + L D + +QS EQ E + +NF Q + QL +
Sbjct: 119 LQQQEAKPDG-LVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKS 177
Query: 1308 KLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQ 1367
K D +A + E L + + +ELLQ+ E L+++ ++TL
Sbjct: 178 KYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLM 237
Query: 1368 ENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSN 1427
+N T E ER E ++LK++ LQ + I +L
Sbjct: 238 DN---------MTLERER--------ESEKLKDECKKLQSQYASSEATISQLRSELAKGP 280
Query: 1428 ENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNM 1487
+ V E + L+ +V L ++ L ++ K + + K+ E + + + +Q T
Sbjct: 281 QEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQAT-- 338
Query: 1488 KFSMMLREKEFECHSMKEKALAFEQLLKE--KEQGKTGELNQLLNA-VKSMQEKTVVFQQ 1544
L +K+ +C ++ + A E L E + GE Q L + ++ K +
Sbjct: 339 -----LHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKA 393
Query: 1545 ERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED 1604
E Q+ ++K+ LQ+E+ +L K + ++L L E + + + E
Sbjct: 394 EFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQ 453
Query: 1605 REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQE 1664
+ A L+ K++ LEE+L HQ + QEQ + T +L +Q
Sbjct: 454 QVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQ----QALQQSTTAKLREAQN 509
Query: 1665 QVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLD 1724
++Q + + +++ + A L+K K+ I+ +K E+L K+ + +
Sbjct: 510 DLEQVLRQIGDKDQKIQNLE--------ALLQKSKENISLLEKEREDLYAKIQAGEGETA 561
Query: 1725 EANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLM 1784
N + L EQ+ + E+LK Q+E ++ +++ ++ D+VL
Sbjct: 562 VLNQLQEKNHTLQEQV---TQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLS 618
Query: 1785 RNLFIGHFHTPKNQRHE 1801
+ ++ N+ E
Sbjct: 619 LETSVNELNSQLNESKE 635
Score = 77.4 bits (189), Expect = 1e-13
Identities = 140/668 (20%), Positives = 258/668 (38%), Gaps = 118/668 (17%)
Query: 36 DMLMEGTE-----EVEAELPDSRTKEIEAIHAILRSENERLKKLCTD---LEEKHEASEI 87
D+ + TE E+E E+ S +++ L S ++L K + L++ E
Sbjct: 762 DLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQ 821
Query: 88 QIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFA 147
+ K Q N++Q E+ +K + AL +L ++ V + S F
Sbjct: 822 ETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL----KNSKSEFE 877
Query: 148 YGISHHPSAF-----------HDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQ 196
+A H + + + Q+E+ + + E E H +
Sbjct: 878 KENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEK----EKEASHQLKLEL 933
Query: 197 TS------KAQGTDNSDQSEICKLQNIIKELKQNRSQ---EIDDHQHEMSV-------LQ 240
S +AQ T ++ E +LQ I ELKQ+ Q +I+ Q E+ + L+
Sbjct: 934 NSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELE 993
Query: 241 NAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIE 300
N QQ+LT+ + +EL+ +E+I L+N ++ Q+T + LQ +
Sbjct: 994 NKLQQQLTQAA----QELAAEKEKISVLQNNYEKS---------------QETFKQLQSD 1034
Query: 301 KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKL 360
++ +K + +KLS A+ D L + Q+ + + I E LK + L
Sbjct: 1035 FYGRESELLATRQDLKSVEEKLSLAQED---LISNRNQIGNQNKLIQE----LKTAKATL 1087
Query: 361 QPSAVKQSDTMTE---------KERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDN 411
+ + K+ + E KE+ L + V E +L + + ++ LN++
Sbjct: 1088 EQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEE- 1146
Query: 412 SLAEDNLKLKMRIEVLEKEKSLLSQEKEELQ--MSLLKLNNEYEVIKSTATRDISLDSEL 469
L L+ I L+ K LL Q+K ELQ LK E E +D + E
Sbjct: 1147 -LKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKD-QVKKEE 1204
Query: 470 HDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSII 529
+L+ KE +L+ I EKE + + EE + + L+ Q + +
Sbjct: 1205 EELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAK--------------LTMQITALNENL 1250
Query: 530 SKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLV 589
+K++ ++RV +LE D+ E+ V LE V+N
Sbjct: 1251 GTVKKEWQSSQRRVSELEKQTDDLRGEIAV---------------------LEATVQNNQ 1289
Query: 590 DQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREA 649
D+ E + + E +L+ + + + +L + + ++ + K T R+
Sbjct: 1290 DERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKW 1349
Query: 650 EVRNLKQN 657
N QN
Sbjct: 1350 AEDNEVQN 1357
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 197 bits (500), Expect = 1e-49
Identities = 351/1685 (20%), Positives = 695/1685 (41%), Gaps = 252/1685 (14%)
Query: 174 INRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQ 233
I + + + LE E+ R T +GT + ++ +L ++ E + Q + +
Sbjct: 41 IQKAKSRCTELEKEIEELRSKPVT---EGTGDIIKALTERLDALLLEKAETEQQCLSLKK 97
Query: 234 HEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKT 293
+ + Q + +T++ H+E + ++E+ENL + + SK E +
Sbjct: 98 ENIKMKQEV-EDSVTKMGDAHKELEQSHINYVKEIENLKNE-----LMAVRSKYSEDKAN 151
Query: 294 IQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENL 353
+Q K++E+ + +++++L N D +++ QE++ + E+ L
Sbjct: 152 LQ----------KQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYL 201
Query: 354 KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSL 413
+ +L + ++ +T+T+ + I+ ++ Q+ ++ + E+++L +++Q
Sbjct: 202 Q---KQLDATTDEKKETVTQLQNIIEANSQ-----HYQKNINSLQEELLQLKAIHQ---- 249
Query: 414 AEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLR 473
E+ +L +IE KE + EL+ +L+K + E + + + E
Sbjct: 250 -EEVKELMCQIEASAKEHEAEINKLNELKENLVK---QCEASEKNIQKKYECELE----- 300
Query: 474 LNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK 533
NL NQ L+ E +++ E KH+ +D L + +++ S LK
Sbjct: 301 -NLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHL---EDTLKELESQH----SILK 352
Query: 534 QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL- 592
++ +LE D I E ++E L E +N+L L K++ +E L +L
Sbjct: 353 DEVTYMNNLKLKLEMDAQHIKDEFFHEREDL---EFKINELLLAKEEQGCVIEKLKSELA 409
Query: 593 NKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKD---------TL 643
+++ ++++ N E++ Q+++E+S + + ++ + + L
Sbjct: 410 GLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENL 469
Query: 644 LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQL 703
+E++ + N + +E L L + A + E E + H+L++ L
Sbjct: 470 QQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKL---RTA 526
Query: 704 SLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEE-----LSNARNLNTSALQ 758
EK+ ++ET+ +GE E L +++ L+ E K ++E L + +T +
Sbjct: 527 FTEKDALLETVNRLQGENEKLL--SQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKE 584
Query: 759 LEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIE 818
LE + + L ++KD I +LK + E+MD HK+ + LE K++ Q I +
Sbjct: 585 LEGK-INSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQ 643
Query: 819 KLKERSSKLQE---ELDKYSQALRKNEILRQTIEEKDRSLG----SMKEENNHLQEELER 871
K+ E + L+E E D+ Q L K + + + E L S+ EENN L E ++
Sbjct: 644 KVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQ 703
Query: 872 LREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKM---- 927
L SR V + D + L ++QL + + EE + K++E++ K+
Sbjct: 704 L----SRDLEVFLSQKEDVI--LKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKT 757
Query: 928 QLLQSLQEQKKEMDEFRYQHEQMNATHT----------------------QLFLEKD--- 962
QL L+E E+ E + + +N L LEK+
Sbjct: 758 QLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKC 817
Query: 963 ---------EEIKSLQKTIEQIKTQLHEERQDIQTD----NSDIF------QETKVQSLN 1003
EE+KSL + EQ K L +E ++IQ++ SD+ ++T++++ N
Sbjct: 818 LQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQN 877
Query: 1004 ----IENGSEKHDLSKAETERLVKGIKERE-----LEIKLLNEKNISLTKQIDQLSKDEV 1054
+E S+ S+ E+ IKE E LE K L ++ L D L+K
Sbjct: 878 LLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPS 937
Query: 1055 GKLTQIIQQKDLE--IQALHARISSTSHTQDVVYL-----QQQLQAYAMEREKVFAVLNE 1107
K + K+LE I+ L + + L +++L + E + V L
Sbjct: 938 VKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELES 997
Query: 1108 KTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR 1167
E L ++ + + L++ + ++++L E + F I++L+R +R
Sbjct: 998 LRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANN--FEHRIEDLTRQLR 1055
Query: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGN--------------------------------E 1195
++ + ++ + LLA ++T + +
Sbjct: 1056 NSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIK 1115
Query: 1196 AGGVNSNQFEELLQERDKLKQQVKK-MEEW----KQQVMTTVQNMQ-HESAQLQEELHQ- 1248
N+ EEL + K K+Q++K M+E K TT+ NM+ + +L +EL+Q
Sbjct: 1116 EHATTVNELEELQVQLQKEKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQK 1175
Query: 1249 ----------LQAQVLVDSDNNSKLQVDYTGL---IQSYEQNETKLKNFGQELAQVQHSI 1295
L+ ++ + LQ + T L +Q YE+ TK+K Q L + +
Sbjct: 1176 LTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIK---QLLVKTKK-- 1230
Query: 1296 GQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKS 1355
+L ++K L I+ L + Q E + +E+ SE ++ E L+ S
Sbjct: 1231 -ELADSKQAETDHL-ILQASLKGELEASQQQVEVYKIQLAEITSEKHKI----HEHLKTS 1284
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++ T+ Q+ L + A + E SE + K + + K K K +
Sbjct: 1285 AEQHQRTLSAYQQRVTALQEECRAA----KAEQATVTSEFESYKVRVHNVLKQQKNKS-M 1339
Query: 1416 IKAKSDQLLSSNENFTNKVNENEL-LRQAVTNLKERILILEMDIGKLKGENEKIVETYRG 1474
+A+++ E+ +++ ++ L+ + NL+ + ++ L+ E++ ++E +
Sbjct: 1340 SQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINV----SELQTLQSEHDTLLERHN- 1394
Query: 1475 KETEYQALQETNMKFSMMLREK----EFECHSMK-EKALAFEQLLKEKEQGKTGELNQLL 1529
+ LQET K LREK + E MK E QL + E + +Q+
Sbjct: 1395 -----KMLQETVSK-EAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVR 1448
Query: 1530 NAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQ--NEVQRLRDKEFRSNQELERLRNH 1587
+ + ++ QQ+ ++ L Q + E T + Q L++ R N +L L H
Sbjct: 1449 HLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMH 1508
Query: 1588 LLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNV 1647
+ E+ E E + LE+ L S +E A E L ++L+
Sbjct: 1509 TVTREEGEGMETTDTES-VSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSS 1567
Query: 1648 VSKQRD-------ETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQ 1700
+K D ET ++ EQ+K + LE Q+ EK+ +A LE K
Sbjct: 1568 TTKSADHLNGLLRETEATNAILMEQIKLLKSEIRR----LERNQEREKS--AANLEYLKN 1621
Query: 1701 LIAEW 1705
++ ++
Sbjct: 1622 VLLQF 1626
Score = 181 bits (460), Expect = 5e-45
Identities = 354/1664 (21%), Positives = 685/1664 (41%), Gaps = 344/1664 (20%)
Query: 44 EVEAELPDSRTKEI-EAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQ 102
E+E E+ + R+K + E I+++ ERL L + E + + +K+++ + +++
Sbjct: 50 ELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQC-LSLKKENIKMKQEVED 108
Query: 103 ---------KEVEISHLK-ARQIA-LQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGIS 151
KE+E SH+ ++I L+++L+ ++S + A ++
Sbjct: 109 SVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNT------ 162
Query: 152 HHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSE- 210
+ + F + +S+ + +L E+ ++ G I K ++ E
Sbjct: 163 ---QLELSEQLKFQN--NSEDNVKKLQEEIEKIRP--GFEEQILYLQKQLDATTDEKKET 215
Query: 211 ICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEEL-- 268
+ +LQNII+ Q+ + I+ Q E+ L+ HQ+++ E+ + ++E I +L
Sbjct: 216 VTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNE 275
Query: 269 --ENLLQQGGSGVIETDLSKIYEMQ------------KTIQVLQIEKVESTKKMEQLEDK 314
ENL++Q + E ++ K YE + + Q+ I E+T + + +K
Sbjct: 276 LKENLVKQCEAS--EKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEK 333
Query: 315 IKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLEC--------SKLQPSAVK 366
+K + L E+ IL+ E +N K ++ + +++K E K+ +
Sbjct: 334 VKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLA 393
Query: 367 QSDTMTEKERILAQSASVEEVF------RLQQALSDAENEIMRLSSLNQD--NSLAEDNL 418
+ + E++ ++ A + + F ++ S E +S LN+ + ++ L
Sbjct: 394 KEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKL 453
Query: 419 KLKMRIEVLEKEKSLLSQEKE------------------ELQMSLLKLNNEYEVIKSTAT 460
L I+ L+++ L QEK+ EL S K++ E+E +K
Sbjct: 454 TLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQA 513
Query: 461 RDI-SLDSELH------DLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMIL 513
D+ L +L D L + Q N+ + ++ L+ E+E + QE +L
Sbjct: 514 SDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLL 573
Query: 514 -----------IKDQLSKQQNEGDSIISKLK----------------------------- 533
++ +++ E D I+KLK
Sbjct: 574 SLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQ 633
Query: 534 --QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQ 591
Q ++ +++V++L + KE D +KL + V + L K+ L +V++L ++
Sbjct: 634 TIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEE 693
Query: 592 LNK--SQESNVS-------IQKENLELKEHIRQNEEELSRI------RNELMQSLNQDSN 636
NK S++ +S QKE++ LKEHI Q E++L + N+L++ N+
Sbjct: 694 NNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLE--NEQVQ 751
Query: 637 SNFKDT----LLKE---------REAEVRNLKQNLSE-LEQLNENLKKVAF--------- 673
F T LKE E +V N+ Q + E L ++NE +AF
Sbjct: 752 KLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLEL 811
Query: 674 --DVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKR 731
++K E+ V+ CE+++ L + E+ ++ L+ E EI++E +
Sbjct: 812 EKEIKCLQEESVVQCEELKSLLRD---------YEQEKVL--LRKELEEIQSEKEALQSD 860
Query: 732 LLEEANKYEKT----------IEELSNA------RNLNTSALQLEHEHLIKLNQKKDM-- 773
LLE N EKT +EE+S N EHE+L L ++K++
Sbjct: 861 LLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRD 920
Query: 774 ---EIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
E+ LK ++ + + + + E+ + L + +KE I K+K + K ++E
Sbjct: 921 RRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKE 980
Query: 831 LD---KYSQALRKNEILRQTIEEKDRSLGSMK------EENNHLQEELERLREE---QSR 878
LD K +Q ++ E L EKD+ SM+ E +L E E+ E+ +
Sbjct: 981 LDSSRKETQTVK--EELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKE 1038
Query: 879 TAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQK- 937
A + + D +L + Q TI E+ + + + Q+ +K+ +Q L+ Q+
Sbjct: 1039 RANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETL---QSNAKLLEVQILEVQRA 1095
Query: 938 -----KEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSD 992
KE++ + Q EQ H E++ LQ +++ K QL + Q+++ D
Sbjct: 1096 KAMVDKELEAEKLQKEQKIKEHATTV----NELEELQVQLQKEKKQLQKTMQELELVKKD 1151
Query: 993 IFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKN--------ISLTK 1044
Q+T + ++ I A+ ERL+K EL KL N+ N I + K
Sbjct: 1152 A-QQTTLMNMEI-----------ADYERLMK-----ELNQKLTNKNNKIEDLEQEIKIQK 1194
Query: 1045 QIDQLSKDEVGKLTQIIQQ---KDLEIQAL---------HARISSTSHTQDVVYLQQQLQ 1092
Q + ++E+ L +QQ K+ +I+ L ++ + T H L+ +L+
Sbjct: 1195 QKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELE 1254
Query: 1093 AYAMERE----KVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENK--KLSTR 1146
A + E ++ + +EK + + HLKT + ++A + + LQ+E + K
Sbjct: 1255 ASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQA 1314
Query: 1147 FESSGQDMFRETIQNLSRIIREKDI----------EIDALSQKCQTLLAVLQTSSTGNEA 1196
+S + ++ + N+ + + K + E + L L LQ S +
Sbjct: 1315 TVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQ- 1373
Query: 1197 GGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVD 1256
+N ++ + L E D L ++ KM +Q + A+L+E+L +Q++
Sbjct: 1374 --INVSELQTLQSEHDTLLERHNKM----------LQETVSKEAELREKLCSIQSE---- 1417
Query: 1257 SDNNSKLQVDYTGLI-QSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQ 1315
N ++ ++T + Q QNE +F ++ +Q + T L K++ Q
Sbjct: 1418 ---NMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQ 1474
Query: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSD 1375
L K+E + S QQ L+ LR+ + + L D
Sbjct: 1475 L-----------------KNEPTTRSPVSSQQSLKNLRER-----------RNTDLPLLD 1506
Query: 1376 SIAATSELERKEHEQTDSE-IKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKV 1434
T E E + E TD+E + L++LL + ++ + E K+
Sbjct: 1507 MHTVTRE-EGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKL 1565
Query: 1435 NE--------NELLRQA-VTN--LKERILILEMDIGKLKGENEK 1467
+ N LLR+ TN L E+I +L+ +I +L+ E+
Sbjct: 1566 SSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQER 1609
Score = 151 bits (381), Expect = 7e-36
Identities = 235/1175 (20%), Positives = 500/1175 (42%), Gaps = 167/1175 (14%)
Query: 659 SELEQL-NENLKKVAFDVKMENEKLVLACEDVRHQLEECLA-----GNNQLSLEKNTIVE 712
S+LE L E+L K A M +K C ++ ++EE + G + ++
Sbjct: 20 SKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLD 79
Query: 713 TLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD 772
L +EK E E + KK ++ + E ++ ++ +A +LE H+ N K+
Sbjct: 80 ALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHK------ELEQSHI---NYVKE 130
Query: 773 MEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELD 832
+E LK + + + + E K L LEE ++++ F ++ KLQEE++
Sbjct: 131 IE--NLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIE 188
Query: 833 KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVT 892
K +E+ +LQ++L+ +E+ T
Sbjct: 189 KIRPGF--------------------EEQILYLQKQLDATTDEKKET------------- 215
Query: 893 ELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKE-MDEFRYQHEQMN 951
V+QL I +E +H+QK I + +QL QE+ KE M + ++
Sbjct: 216 -----VTQLQNI---IEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHE 267
Query: 952 ATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKH 1011
A +L K+ +K + + + I+ + E ++++ S+ Q+ ++ S+ ++ +
Sbjct: 268 AEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVE 327
Query: 1012 DLSKAETERLVKGIKERELEIKLLNEK-----NISLTKQID-QLSKDEVGKLTQIIQQKD 1065
+ + + L +KE E + +L ++ N+ L ++D Q KDE +++D
Sbjct: 328 QVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEF-----FHERED 382
Query: 1066 LEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDI 1125
LE + ++ + L+ +L + ++ + V + RE LK ++ K +I
Sbjct: 383 LEFKINELLLAKEEQGCVIEKLKSELAG--LNKQFCYTV-EQHNREVQSLKEQHQK--EI 437
Query: 1126 VAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLA 1185
E L E +KL+ FE G +E +NL + +E + ++L + ++
Sbjct: 438 SELNETFLS--DSEKEKLTLMFEIQG---LKEQCENLQQEKQEAILNYESLRE----IME 488
Query: 1186 VLQTSSTGNEAGGVNSNQFEELLQER----DKLKQQVKKMEEWKQQVMTTVQNMQHESAQ 1241
+LQT E+ G S +FE + Q++ +L+Q+++ K ++ TV +Q E+ +
Sbjct: 489 ILQTEL--GESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEK 546
Query: 1242 LQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
L Q +++ + +N K + G+ + S Q +T LK +++ I L
Sbjct: 547 LLS-----QQELVPELENTIKNLQEKNGVYLLSLSQRDTMLK-------ELEGKINSLTE 594
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLR--ASKSEVLSESSELLQQELEELRKSLQE 1358
KD + KL ++ + + + K E + + L+Q++ EL L+E
Sbjct: 595 EKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEE 654
Query: 1359 KDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL----QKLLKEKDL 1414
T++ +N+ +L + + ++ ++ E +E+K L E+ + L ++L ++ ++
Sbjct: 655 ---TLKEKDQNDQKL-EKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEV 710
Query: 1415 LIKAKSDQLLSSNENFTNK-----VNENELLRQAVTNLKERILILEMDI-GKLKGENEKI 1468
+ K D +L + K V E + L + + N + + L ++ + G LK ++
Sbjct: 711 FLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEV 770
Query: 1469 VETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQL 1528
E K+ LQ + + EK EK L E+ +K ++ + +L
Sbjct: 771 SEDSEEKDV-VNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEEL 829
Query: 1529 LNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHL 1588
+ ++ +++ V+ ++E +++ Q E ALQ+++ +++ ++ E + L +
Sbjct: 830 KSLLRDYEQEKVLLRKELEEI-------QSEKEALQSDLLEMKNANEKTRLENQNLLIQV 882
Query: 1589 LESEDSYTREAL-----------------AAEDREAKLRKKVTVLEEKLVSSSNAMENAS 1631
E + ++ + E +E + R+ +L + ++ S +++N
Sbjct: 883 EEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDP 942
Query: 1632 HQASVQVESLQEQLNVVSKQRDETALQLS-VSQEQVKQYALSLANLQMVLEHFQ--QEEK 1688
+ ++E E L K+++E ++ V+ + K+ S Q V E + + EK
Sbjct: 943 LSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEK 1002
Query: 1689 AMYSAEL-------EKQKQLIAEWKKNAE----------NLEGKVISLQECLDEANAALD 1731
SA + E K L+ E++K +E N E ++ L L + +
Sbjct: 1003 DQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCE 1062
Query: 1732 SASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQK 1766
+ + E L + IE L+ +L + + +VQ+
Sbjct: 1063 TINSDNEDLLAR---IETLQSNAKLLEVQILEVQR 1094
Score = 45.8 bits (107), Expect = 4e-04
Identities = 62/270 (22%), Positives = 114/270 (42%), Gaps = 45/270 (16%)
Query: 1546 RDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQE------LERLRNHLLESEDSYTREA 1599
+ Q+ML K K T L+ E++ LR K ERL LLE ++ ++
Sbjct: 35 KKQMMLIQKAKS-RCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAET-EQQC 92
Query: 1600 LAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQL 1659
L+ + K++++V K+ + +E + ++E+L+ +L V + E L
Sbjct: 93 LSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANL 152
Query: 1660 SVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK------------QKQLIA--EW 1705
E+ L L+ Q+ ++ ++ E+EK QKQL A +
Sbjct: 153 QKQLEEAMNTQLELSE-QLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDE 211
Query: 1706 KK------------NAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEE--QIEELK 1751
KK N+++ + + SLQE L + A Q +VKE QIE
Sbjct: 212 KKETVTQLQNIIEANSQHYQKNINSLQEELLQLKA--------IHQEEVKELMCQIEASA 263
Query: 1752 RQNELRQEMLDDVQKKLMSLANSSEGKVDK 1781
+++E L+++++ L+ +SE + K
Sbjct: 264 KEHEAEINKLNELKENLVKQCEASEKNIQK 293
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 195 bits (495), Expect = 4e-49
Identities = 353/1652 (21%), Positives = 690/1652 (41%), Gaps = 241/1652 (14%)
Query: 233 QHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM-- 290
Q E +L + H Q +++S EL Y + ++ ENL+ + DL K ++
Sbjct: 1415 QSEHKILHDQHCQMSSKMS-----ELQTYVDSLKA-ENLVLSTNLRNFQGDLVKEMQLGL 1468
Query: 291 -QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEE 349
+ + L V + + L D + L D +L N+E +
Sbjct: 1469 EEGLVPSLSSSCVPDSSSLSSLGDS--SFYRALLEQTGDMSLLS------NLEGAVSANQ 1520
Query: 350 CENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQ 409
C ++ CS LQ + +T KE A + VEE+ L E+ R S
Sbjct: 1521 CSVDEVFCSSLQ------EENLTRKETPSAPAKGVEELESLC--------EVYRQSLEKL 1566
Query: 410 DNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSEL 469
+ + + I+ LE+ LLS E++EL + +E E + T ++L+ E
Sbjct: 1567 EEKMESQGIMKNKEIQELEQ---LLSSERQELDCLRKQYLSENEQWQQKLT-SVTLEMES 1622
Query: 470 HDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI- 528
+L E K+ +E+ +L E+ L Q + + +L D Q +S
Sbjct: 1623 ---KLAAEKKQ-------TEQLSLELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCD 1672
Query: 529 ISKLKQDLNDE---KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV 585
ISK E K VHQ+ D D ++L++ EK+ ++ + ++ D
Sbjct: 1673 ISKEHTSETTERTPKHDVHQICDK--DAQQDLNLDIEKITETGAVKPTGECSGEQSPDTN 1730
Query: 586 ENLV--DQLNKSQE--SNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKD 641
D+ S E S +S N + N+E++ + L + + SN N +
Sbjct: 1731 YEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDI----HNLQLRVKETSNENLRL 1786
Query: 642 T-LLKEREAEVRNLKQNLSELEQ---LNE-----------NLKKVAFDVKMENEKL---- 682
++++R+ +V +L + EL+ L E L+K+ ++K EN L
Sbjct: 1787 LHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELEKIVGELKKENSDLSEKL 1846
Query: 683 -VLACE--DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL--CWAKKRLLEEAN 737
+C+ ++ ++E N+ L + + ++ + + G+ A++ W K+R L+ N
Sbjct: 1847 EYFSCDHQELLQRVETSEGLNSDLEMHAD---KSSREDIGDNVAKVNDSW-KERFLDVEN 1902
Query: 738 KYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKET----- 792
ELS R+ S +EHE L + D+E+ + +K + D ++K+
Sbjct: 1903 -------ELSRIRSEKAS---IEHEALYL---EADLEVVQTEKLCLEKDNENKQKVIVCL 1949
Query: 793 KDVLSSSLEEQKQLT---QLINKKEIFIEKLKERSSKLQEELDKY-SQALRKNEILRQTI 848
++ LS E+ QL ++KK +++L E+ + +EL+ + S+ L ++ +
Sbjct: 1950 EEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEV 2009
Query: 849 EEKDRSLGSMK-------EENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQL 901
+EK L ++ ++ HLQE+L+ L ++ + EL ++++QL
Sbjct: 2010 KEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTK--------CELENQIAQL 2061
Query: 902 NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEK 961
N KE L +E + Q + + + K+ + ++L+ E EF + + TQ
Sbjct: 2062 NKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFA-----LRLSSTQ----- 2111
Query: 962 DEEIKSLQKTIEQI--------KTQLH--EERQDIQTDNSDIFQETKVQSLNIENGSEKH 1011
EE+ L++ IE++ K QLH E+ ++ + +N + + + ++ E
Sbjct: 2112 -EEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEENQ 2170
Query: 1012 DL-------SKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQK 1064
+L SKAE E L I+E +K+ ++L + + L+K IQ+K
Sbjct: 2171 ELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQ--------IQEK 2222
Query: 1065 DLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFA-VLNEKTRENSHLKTEYHKMM 1123
++ L +SS + ++ ++Q + E K +L + +E +
Sbjct: 2223 QGQLSELDKLLSSF---KSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQ 2279
Query: 1124 DIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI--IREKDIEIDALSQKCQ 1181
+I+ A E +L +E +L E + + + L + ++E + D L + +
Sbjct: 2280 EIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVE 2339
Query: 1182 TLLAVLQTSSTGNEAGGVNS-NQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
L L+ + T E + + N E+ + K++ + + + V+T ++ +
Sbjct: 2340 NLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTN 2399
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
+LQ+E ++ +++S + LQ +Q E++ T ++ +L ++ + L N
Sbjct: 2400 ELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHN 2459
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSE--VLSESSELLQQELEELRKSLQE 1358
++ K +S Q+ L Q + L +K+ VL S L QE+E+ ++ L++
Sbjct: 2460 DQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEK 2519
Query: 1359 KDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKA 1418
KD I L+ +++ D S+L Q + E + KE+ L+ L E ++
Sbjct: 2520 KDEEISRLK---NQIQDQEQLVSKLS-----QVEGEHQLWKEQNLELRNLTVE----LEQ 2567
Query: 1419 KSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETE 1478
K L S N + + + E+L+ + NL+ + + +MD K + V KETE
Sbjct: 2568 KIQVLQSKNASLQDTL---EVLQSSYKNLENELELTKMD----KMSFVEKVNKMTAKETE 2620
Query: 1479 YQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEK 1538
Q E H M +K ++ L ++ GEL LL +KS +++
Sbjct: 2621 LQR-----------------EMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663
Query: 1539 TVVFQQERDQVMLALKQKQMENTALQNEV-QRLRDKEFRSNQELERLRNHLLESEDSYT- 1596
E ++ +L + + +V + + + + R ++ ++ + LL++ Y
Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 1597 -----REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQV-ESLQ-------E 1643
RE L +++ +K LE L+ SS N S +A+ Q+ E L+ +
Sbjct: 2724 EIQTYREKLTSKEECLSSQK----LEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLK 2779
Query: 1644 QLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ--QEEKAMYSAELEKQKQL 1701
+N + K+ + ++ + + KQ LQ L Q QE++ + K +L
Sbjct: 2780 YVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMDTKVDEL 2839
Query: 1702 IAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEEL----KRQNELR 1757
E K+ E LE K E LD+ + L S +L + ++ E Q+ L +Q+
Sbjct: 2840 TTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAHLCSQQSKQDSRG 2899
Query: 1758 QEMLDDV-----------QKKLMSLANSSEGK 1778
+L V +K+L S N + GK
Sbjct: 2900 SPLLGPVVPGPSPIPSVTEKRLSSGQNKASGK 2931
Score = 193 bits (491), Expect = 1e-48
Identities = 425/2048 (20%), Positives = 832/2048 (40%), Gaps = 347/2048 (16%)
Query: 1 MSSWLGGLGSGLGQSLGQVGGSLASLTG--QISNFTKDMLMEGTEEVEAELPDSRTKEIE 58
+ W GL + Q + ++ G L L Q F D L ++ + ++ + +T+
Sbjct: 5 LEEWKEGLPTRALQKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTN 64
Query: 59 AIHAILRSENERLKKLCTDLEEKHE--ASEIQIKQQSTSYR-NQLQQKEVEISHLKARQI 115
L+ EN+RL ++C LE+ + + E+Q+K+ +++ QL + +I L+
Sbjct: 65 -----LKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELK 119
Query: 116 ALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDM--DFGDIISSQ-Q 172
+ +L + Q AAQS P T F ++ PS ++ D + + + +
Sbjct: 120 RCKSELERSQQAAQSADVSLN-PCNTPQKIFTTPLT--PSQYYSGSKYEDLKEKYNKEVE 176
Query: 173 EINRLSNEVSRLESE----------VGH---WRHIAQTS---------KAQGTDNSDQSE 210
E RL EV L+++ + H RH A +S + + NS ++
Sbjct: 177 ERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTP 236
Query: 211 I-----CKLQNIIKELKQNRSQ-EIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEER 264
I + +E+ +RS +I S N+ L + + +EL +
Sbjct: 237 IRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQEL---RNK 293
Query: 265 IEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTK------------------ 306
I ELE L QG ++ ++K E+Q ++ ++E +E K
Sbjct: 294 INELE-LRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQ 352
Query: 307 ---KMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEK-RQIMEECENLKLECSKLQP 362
K LE K+K + + LS + + R EQ EK ++ EE + L
Sbjct: 353 ASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQ 412
Query: 363 SAVKQSDTMTEKERILAQSASVEEVF------------RLQQALSDAENEIMRLSSLNQD 410
++ +T++ L Q+ ++ V +L+ L + + ++ R Q
Sbjct: 413 ECIQMKARLTQE---LQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQA 469
Query: 411 NSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELH 470
+ + E+ L+ M E ++KE +LL E+ + L E + IK + + E+
Sbjct: 470 SQIKENELRRSM--EEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMK 527
Query: 471 DLRLNLEAKEQELNQSISEKET---------LIAEIEELDRQNQEATK----HMILIKDQ 517
+ E ++L + I+++E +A++E+ +Q+ K H+ + D+
Sbjct: 528 AKNTSQETMLRDLQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 518 LSKQQNEGDSIISKLK------QDLNDEK-----------KRVHQLEDDKMDITKE---- 556
LSK + E +++S L+ ++L +EK K + Q+E +K ++ +
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHL 647
Query: 557 ---LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNK---------------SQES 598
L Q+ K + + L + ++ L ++ NL + L+ Q++
Sbjct: 648 ETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKA 707
Query: 599 NVSIQKENLELKE----------HIRQNEEELSRIRNELMQS--LNQDSNSNFKD--TLL 644
S QK E++ + E +L + NE+M QD ++ ++ LL
Sbjct: 708 EFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLL 767
Query: 645 KEREAEVRNLKQNLSELEQLNE----------------NLKKVAFDVKME---NEKLVLA 685
K ++A + + + L ++ ++ + ++E + K
Sbjct: 768 KSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGSMPSERSECRLEADQSPKNSAI 827
Query: 686 CEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKR----LLEEANKYEK 741
++ LE L Q++ + E L KGEIE L A++ + E + + K
Sbjct: 828 LQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQRISK 887
Query: 742 TIEELSNARNL---NTSALQLEHEHLIKLNQK---KDMEIAELKKNIEQMDTDHKETKDV 795
E+ S +N+ SAL+ + + L LN K + EI ELKK+ ++ KE + +
Sbjct: 888 LQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ-L 946
Query: 796 LSSSLE-EQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQ----ALRKNEILRQTIEE 850
LS +L E+K+++ +I+ + IE+L + + L+E +Q ++K+E I+E
Sbjct: 947 LSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYIDE 1006
Query: 851 KDRSLGSMKEENNHLQ-------EELERLREEQSRTAPVADPKT------LDSVTELASE 897
+++S+ + ++ + EE E+ S+ A K L+ T L
Sbjct: 1007 REKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCE- 1065
Query: 898 VSQLNTIKEHLEEEIKHHQKII------EDQNQSKMQLLQSLQEQ-KKEMDEFRYQHEQM 950
++ N +++ E K HQ+ + E++NQ+ M L+++Q+ + EM + + +
Sbjct: 1066 -NRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSEMTDNQNNSKSE 1124
Query: 951 NATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK 1010
Q + EE +QK + + L E Q ++ +TK + N+E+ +
Sbjct: 1125 AGGLKQEIMTLKEEQNKMQKEVNDL---LQENEQLMKV------MKTKHECQNLESEPIR 1175
Query: 1011 HDLSKAETERLVKGIK-ERELEIK--LLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDL- 1066
+ + + E+ER K + +LE+K L+ N L Q++ + +++ KL + ++K+
Sbjct: 1176 NSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLV-QLEAMLRNKELKLQESEKEKECL 1234
Query: 1067 --EIQALHARISSTSHTQDVVYLQ-QQLQAYAMEREKVFA----VLNEKTRENSHLKTEY 1119
E+Q + + TS+ QD+ + L+ ++ E+ + L+ +N+HL+
Sbjct: 1235 QHELQTIRGDL-ETSNLQDMQSQEISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSL 1293
Query: 1120 HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQK 1179
M+ + E LQ E +L T S + T + ++ + + E+ L+
Sbjct: 1294 QTTMNKLNELEKICEILQAEKYELVTELNDSRSECITAT-RKMAEEVGKLLNEVKILNDD 1352
Query: 1180 CQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHES 1239
L L G E G + Q L D+ + + ++V +Q +
Sbjct: 1353 SGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDE-SNSYEHLTLSDKEVQMHFAELQEKF 1411
Query: 1240 AQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
LQ E L Q S S+LQ L T L+NF +L
Sbjct: 1412 LSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQGDL----------- 1460
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASK--SEVLSESSEL-LQQEL------- 1349
K++ LG + + P LSS+ + S L S +L ++ ++ L L
Sbjct: 1461 -VKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSAN 1519
Query: 1350 -----EELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEI--------K 1396
E SLQE++ T + + + + + E+ R+ E+ + ++ K
Sbjct: 1520 QCSVDEVFCSSLQEENLTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKMESQGIMKNK 1579
Query: 1397 QLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENEL---LRQAVTNLKERILI 1453
+++E + +L +E D L K Q LS NE + K+ L + A + L
Sbjct: 1580 EIQELEQLLSSERQELDCLRK----QYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLS 1635
Query: 1454 LEMDIGKL---------------------KGENEK--IVETYRGKETE------------ 1478
LE+++ +L +G NE I + + + TE
Sbjct: 1636 LELEVARLQLQGLDLSSRSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICD 1695
Query: 1479 YQALQETNMKFSMMLR----EKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLL----N 1530
A Q+ N+ + + EC + +E ++K QG + +++L N
Sbjct: 1696 KDAQQDLNLDIEKITETGAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPN 1755
Query: 1531 AVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRS-NQELERL--RNH 1587
A+ M + Q++ + L +K+ EN L + ++ RD++ S E++ L + H
Sbjct: 1756 ALVPMD--FLGNQEDIHNLQLRVKETSNENLRLLHVIED-RDRKVESLLNEMKELDSKLH 1812
Query: 1588 LLESEDSYTREA-LAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLN 1646
L E + EA + E +L+K+ + L EKL S HQ +Q E LN
Sbjct: 1813 LQEVQLMTKIEACIELEKIVGELKKENSDLSEKLEYFS-----CDHQELLQRVETSEGLN 1867
Query: 1647 ------VVSKQRDETALQLSVSQEQVKQYALSLAN--LQMVLEHFQQEEKAMY-SAELEK 1697
R++ ++ + K+ L + N ++ E E +A+Y A+LE
Sbjct: 1868 SDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEV 1927
Query: 1698 QKQLIAEWKKNAENLEGKVISLQECL-------DEANAALDSASRLTEQLDVKEEQIEEL 1750
+ +K+ EN + ++ L+E L ++ LD+ S+ T LD E+++E
Sbjct: 1928 VQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEK 1987
Query: 1751 KRQNELRQ 1758
++ E Q
Sbjct: 1988 TQELESHQ 1995
Score = 182 bits (461), Expect = 4e-45
Identities = 397/1861 (21%), Positives = 788/1861 (42%), Gaps = 285/1861 (15%)
Query: 64 LRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHL-----KARQIALQ 118
L EN LK++ L ++ ++ + Q+S S+ N + ++E IS L + + I LQ
Sbjct: 972 LTQENGTLKEINASLNQE----KMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQ 1027
Query: 119 ---------DQLLKLQSAAQSVPSGAGV---PATTASSSFAYGISHHPSAFHDDDMDFGD 166
+ L + AAQ S T+ + + AF + +F
Sbjct: 1028 RCEETGNAYEDLSQKYKAAQEKNSKLECLLNECTSLCENRKNELEQLKEAFAKEHQEFLT 1087
Query: 167 IISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSD--QSEICKLQNIIKELK-- 222
++ +E N+ N + LE+ + Q +++ TDN + +SE L+ I LK
Sbjct: 1088 KLAFAEERNQ--NLMLELET-------VQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE 1138
Query: 223 QNRSQE-----IDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGS 277
QN+ Q+ + +++ M V++ H+ + E S R + + E + N Q
Sbjct: 1139 QNKMQKEVNDLLQENEQLMKVMKTKHECQNLE-SEPIRNSVKERESERNQC-NFKPQMDL 1196
Query: 278 GVIETDL----SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAE----NDR 329
V E L +++ +++ ++ +++ ES K+ E L+ +++ I L ++ +
Sbjct: 1197 EVKEISLDSYNAQLVQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQ 1256
Query: 330 DILRREQEQLNVEKRQIM--EECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEV 387
+I + +++ E++ I E + + + LQ S + + E E+I + E
Sbjct: 1257 EISGLKDCEIDAEEKYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEILQA--EK 1314
Query: 388 FRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLL------------- 434
+ L L+D+ +E + + +AE+ KL +++L + LL
Sbjct: 1315 YELVTELNDSRSECITAT-----RKMAEEVGKLLNEVKILNDDSGLLHGELVEDIPGGEF 1369
Query: 435 -SQEKEELQMSLLKLN--NEYEVIKSTATRDISLD-SELHDLRLNLEAKEQELN----QS 486
Q E+ +SL L+ N YE + + + +++ + +EL + L+L+++ + L+ Q
Sbjct: 1370 GEQPNEQHPVSLAPLDESNSYEHL-TLSDKEVQMHFAELQEKFLSLQSEHKILHDQHCQM 1428
Query: 487 ISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEG--DSIISKLKQDLNDEKKRVH 544
S+ L ++ L +N + ++ + L K+ G + ++ L + +
Sbjct: 1429 SSKMSELQTYVDSLKAENLVLSTNLRNFQGDLVKEMQLGLEEGLVPSLSSSCVPDSSSLS 1488
Query: 545 QLEDDK-----------MDITKELD--VQKEKLIQSEV---ALNDLHLTKQKLEDKVENL 588
L D M + L+ V + EV +L + +LT+++
Sbjct: 1489 SLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQEENLTRKETPSAPAKG 1548
Query: 589 VDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKERE 648
V++L ES + +++LE E + E ++N+ +Q L Q LL
Sbjct: 1549 VEEL----ESLCEVYRQSLEKLE---EKMESQGIMKNKEIQELEQ---------LLSSER 1592
Query: 649 AEVRNL-KQNLSELEQLNENLKKVAFDV-------KMENEKLVLACEDVRHQL------- 693
E+ L KQ LSE EQ + L V ++ K + E+L L E R QL
Sbjct: 1593 QELDCLRKQYLSENEQWQQKLTSVTLEMESKLAAEKKQTEQLSLELEVARLQLQGLDLSS 1652
Query: 694 --------EECLAGNNQ-LSLEKNTIVETLKMEKGEIEAELCW--AKKRLLEEANKYEKT 742
E+ + G N+ + K ET + ++C A++ L + K +T
Sbjct: 1653 RSLLGIDTEDAIQGRNESCDISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITET 1712
Query: 743 -----IEELSNARNLNTS-------ALQLEHEHLIKL-----NQKKDMEIAELKKNIEQM 785
E S ++ +T+ Q E + +L N M+ +++I +
Sbjct: 1713 GAVKPTGECSGEQSPDTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNL 1772
Query: 786 DTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYS-QALRKNEIL 844
KET + E +L +I ++ +E L +L +L Q + K E
Sbjct: 1773 QLRVKETSN-------ENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIE-- 1823
Query: 845 RQTIEEKDRSLGSMKEENNHLQEELERLR-EEQSRTAPVADPKTLDSVTELASEVSQLNT 903
E ++ +G +K+EN+ L E+LE + Q V + L+S E+ ++ S
Sbjct: 1824 --ACIELEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSRED 1881
Query: 904 IKEHLEE-EIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD-EFRYQHEQMNATHTQ-LFLE 960
I +++ + ++ ++ +N+ L ++ +K ++ E Y + T+ L LE
Sbjct: 1882 IGDNVAKVNDSWKERFLDVENE-----LSRIRSEKASIEHEALYLEADLEVVQTEKLCLE 1936
Query: 961 KDEEIKSLQKTIEQIKTQLH---EERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAE 1017
KD E K QK I ++ +L ER ++ + + ++T E EK ++
Sbjct: 1937 KDNENK--QKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESH 1994
Query: 1018 TERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISS 1077
+ I+ E E+K E +L+ + +L KD+ L + +Q + + QAL ++
Sbjct: 1995 QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKT-HLQEKLQSLEKDSQALS--LTK 2051
Query: 1078 TSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ 1137
+ L ++ + E E + A L+E ++Y K+ ++ A EAAL+
Sbjct: 2052 CELENQIAQLNKEKELLVKESESLQARLSE---------SDYEKL-NVSKALEAALV--- 2098
Query: 1138 DENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAG 1197
E + + R S+ +E + L R I + + I+A +K + L+ N++
Sbjct: 2099 -EKGEFALRLSST-----QEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDS- 2151
Query: 1198 GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDS 1257
L + + L+++++ EE ++ V+ +N + E L+ ++ ++ + V
Sbjct: 2152 ---------LKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKV-- 2200
Query: 1258 DNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLS 1317
++D L +S ++N TK Q+Q GQL LL ++ +
Sbjct: 2201 -----FELDLVTL-RSEKENLTK---------QIQEKQGQLSELDKLLSSFKSLLEEKEQ 2245
Query: 1318 SASLLTPQSAECLRASKSEV--LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSD 1375
+ + +S + ++++ L+E+ L + E ++ + Q D I E H+L +
Sbjct: 2246 AEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPI----EEEHQLRN 2301
Query: 1376 SIAAT-SELERKEHEQTDSEIKQLKEKQ---DVLQKLLK--EKDLLIKAKSDQLLSSNEN 1429
SI + LE E +Q ++QLKE + D+L+ ++ E++L I A+++Q ++ E
Sbjct: 2302 SIEKLRARLEADEKKQL-CVLQQLKESEHHADLLKGRVENLERELEI-ARTNQEHAALEA 2359
Query: 1430 FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKF 1489
+K E E L+ + + + + LE+D+ ++ E E + + ++ L+ N F
Sbjct: 2360 ENSK-GEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSF 2418
Query: 1490 SMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV 1549
+L+EKE E MKEK+ ++L Q + ELN+ + A+ + QE
Sbjct: 2419 ENILQEKEQEKVQMKEKSSTAMEML----QTQLKELNERVAALHNDQE------------ 2462
Query: 1550 MLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKL 1609
A K K+ L ++V+ L ++ + Q L+ +N+ + + S ED + KL
Sbjct: 2463 --ACKAKEQN---LSSQVECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKL 2517
Query: 1610 RKKVTVL---------EEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLS 1660
KK + +E+LVS + +E HQ + L V +Q+ + +
Sbjct: 2518 EKKDEEISRLKNQIQDQEQLVSKLSQVE-GEHQLWKEQNLELRNLTVELEQKIQVLQSKN 2576
Query: 1661 VS-QEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISL 1719
S Q+ ++ S NL+ LE + +K + ++ K E ++ + K L
Sbjct: 2577 ASLQDTLEVLQSSYKNLENELE-LTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAEL 2635
Query: 1720 QECLD-EANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGK 1778
QE L E N L E++ ++Q++EL +N ++ LD + K + EGK
Sbjct: 2636 QEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQV----EKEGK 2691
Query: 1779 V 1779
V
Sbjct: 2692 V 2692
Score = 175 bits (443), Expect = 5e-43
Identities = 387/1920 (20%), Positives = 804/1920 (41%), Gaps = 296/1920 (15%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDL--EEK 81
+ LTGQ+ + + + E ++ + + + +HA S + LK L E
Sbjct: 726 SQLTGQVEDLEHKLQLLSNEIMDKD------RCYQDLHAEYESLRDLLKSKDASLVTNED 779
Query: 82 HEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATT 141
H+ S + QQ + + +++ Q ++ + + + A P + +
Sbjct: 780 HQRSLLAFDQQPAMHHS--------FANIIGEQGSMPSERSECRLEADQSPKNSAILQNR 831
Query: 142 ASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTS--- 198
S + + D +++ + EI E + +++E H +A+TS
Sbjct: 832 VDS-LEFSLESQKQMNSDLQKQCEELVQIKGEI-----EENLMKAEQMHQSFVAETSQRI 885
Query: 199 -KAQGTDNSDQSEICK----LQNIIKELK---------QNRSQEIDDHQH---------- 234
K Q ++ Q+ + + L+N KEL+ Q QE+ H
Sbjct: 886 SKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQ 945
Query: 235 ---EMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVI---ETDLSKIY 288
E L+ + +++R EEL+ ++E+ L Q +I E+ + I
Sbjct: 946 LLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQEKMNLIQKSESFANYID 1005
Query: 289 EMQKTIQVL----QIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKR 344
E +K+I L + EK+ ++ E+ + +D+++K +A+ + +L
Sbjct: 1006 EREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQE-------KNSKLECLLN 1058
Query: 345 QIMEECENLKLECSKLQPSAVKQSDTMTEK--------ERILAQSASVEEVFRLQQALSD 396
+ CEN K E +L+ + K+ K + ++ + +V++ R + ++D
Sbjct: 1059 ECTSLCENRKNELEQLKEAFAKEHQEFLTKLAFAEERNQNLMLELETVQQALRSE--MTD 1116
Query: 397 AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK 456
+N +S ++ L ++ + LK ++KE + L QE E+L M ++K +E + ++
Sbjct: 1117 NQN-----NSKSEAGGLKQEIMTLKEEQNKMQKEVNDLLQENEQL-MKVMKTKHECQNLE 1170
Query: 457 STATRDISLDSELHDLRLN------LEAKEQELNQSISEKETLIAEIEELDRQNQEATKH 510
S R+ + E + N LE KE L+ ++ L A + + + QE+ K
Sbjct: 1171 SEPIRNSVKERESERNQCNFKPQMDLEVKEISLDSYNAQLVQLEAMLRNKELKLQESEKE 1230
Query: 511 MILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVA 570
++ +L Q GD S L QD+ ++ + L+D ++D +EK I
Sbjct: 1231 KECLQHEL--QTIRGDLETSNL-QDMQSQE--ISGLKDCEIDA-------EEKYISGPHE 1278
Query: 571 LNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI-----------RQNEEE 619
L+ L+ ++ +++LN+ ++ +Q E EL + R+ EE
Sbjct: 1279 LSTSQNDNAHLQCSLQTTMNKLNELEKICEILQAEKYELVTELNDSRSECITATRKMAEE 1338
Query: 620 LSRIRNELMQSLNQDS---NSNFKDTLLKEREAEVRNLKQ--NLSELEQLN--ENLKKVA 672
+ ++ NE+ + LN DS + + + E N + +L+ L++ N E+L
Sbjct: 1339 VGKLLNEV-KILNDDSGLLHGELVEDIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSD 1397
Query: 673 FDVKM---ENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAK 729
+V+M E ++ L+ + L + + E T V++LK E + L +
Sbjct: 1398 KEVQMHFAELQEKFLSLQSEHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTNLRNFQ 1457
Query: 730 KRLLEEANK--YEKTIEELSNARNLNTSALQLEHE---HLIKLNQKKDMEIAELKKNIE- 783
L++E E + LS++ ++S+L + + L Q DM L N+E
Sbjct: 1458 GDLVKEMQLGLEEGLVPSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMS---LLSNLEG 1514
Query: 784 QMDTDHKETKDVLSSSLEEQKQLTQL---------INKKEIFIEKLKERSSKLQEELDKY 834
+ + +V SSL+E+ LT+ + + E E ++ KL+E+++
Sbjct: 1515 AVSANQCSVDEVFCSSLQEEN-LTRKETPSAPAKGVEELESLCEVYRQSLEKLEEKME-- 1571
Query: 835 SQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE-LERLREEQSRTAPVADPKTLDSVTE 893
SQ + KN+ I+E ++ L S ++E + L+++ L + Q + V TL+ ++
Sbjct: 1572 SQGIMKNK----EIQELEQLLSSERQELDCLRKQYLSENEQWQQKLTSV----TLEMESK 1623
Query: 894 LASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNAT 953
LA+E Q + LE E+ Q ++ + S LL E D + ++E +
Sbjct: 1624 LAAEKKQTEQLS--LELEVARLQ--LQGLDLSSRSLLGIDTE-----DAIQGRNESCD-- 1672
Query: 954 HTQLFLEKDEEIKSLQKTIEQIKTQLHEE--RQDIQTDNSDIFQETKVQSLNIENGSEKH 1011
+ K+ ++ ++T + Q+ ++ +QD+ D I + V+ +G +
Sbjct: 1673 -----ISKEHTSETTERTPKHDVHQICDKDAQQDLNLDIEKITETGAVKPTGECSGEQSP 1727
Query: 1012 DLS-KAETERLVKGIKERELEIK------------LLNEKNI-SLTKQIDQLSKDEVGKL 1057
D + + E +G E E+ L N+++I +L ++ + S + + +L
Sbjct: 1728 DTNYEPPGEDKTQGSSECISELSFSGPNALVPMDFLGNQEDIHNLQLRVKETSNENL-RL 1786
Query: 1058 TQIIQQKDLEIQAL---HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSH 1114
+I+ +D ++++L + S H Q+V L +++A +E EK+ + E +ENS
Sbjct: 1787 LHVIEDRDRKVESLLNEMKELDSKLHLQEV-QLMTKIEA-CIELEKI---VGELKKENSD 1841
Query: 1115 L--KTEY-----HKMMDIVAAKEAALIKLQDENKKLS--------TRFESSGQDMFRETI 1159
L K EY +++ V E L+ K S + S ++ F +
Sbjct: 1842 LSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVE 1901
Query: 1160 QNLSRIIREK------------DIEIDALSQKC--------QTLLAVLQ-----TSSTGN 1194
LSRI EK D+E+ + C Q ++ L+ +S N
Sbjct: 1902 NELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERN 1961
Query: 1195 EAGG---VNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA 1251
+ G S + L Q +K+K++ +++E + + + +Q + E + E L L +
Sbjct: 1962 QLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCIQVAEAEVKEKTELLQTLSS 2021
Query: 1252 QVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDI 1311
V S+L D T L + + E + ++++ I QL K+LL+ + +
Sbjct: 2022 DV-------SELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNKEKELLVKESES 2074
Query: 1312 ISPQLSSAS---LLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQE 1368
+ +LS + L ++ E K E S Q+E+ +LR+ +++ I ++
Sbjct: 2075 LQARLSESDYEKLNVSKALEAALVEKGEFALRLSST-QEEVHQLRRGIEKLRVRIEADEK 2133
Query: 1369 NNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNE 1428
+++ + KE E+ + +K D ++ L E++L + ++ +L+ +
Sbjct: 2134 KQLHIAEKL--------KERERENDSLK------DKVENL--ERELQMSEENQELVILDA 2177
Query: 1429 NFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMK 1488
N E E L+ + + + + E+D+ L+ E E + + + K+ + L +
Sbjct: 2178 E--NSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSS 2235
Query: 1489 FSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQ 1548
F +L EKE +KE++ ++L Q + ELN+ + A+ QE +Q D
Sbjct: 2236 FKSLLEEKEQAEIQIKEESKTAVEML----QNQLKELNEAVAALCGDQEIMKATEQSLDP 2291
Query: 1549 VMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAK 1608
+ E L+N +++LR + ++ + L ESE E+ E +
Sbjct: 2292 PI-------EEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERE 2344
Query: 1609 LRKKVTVLEEKLVSSSNA---MENASHQASVQVESLQE-QLNVVS--KQRDETALQLSVS 1662
L T E + + N+ +E + +SL+ +L+VV+ +++ +L
Sbjct: 2345 LEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKE 2404
Query: 1663 QEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQEC 1722
QE++ + + ++ + +L+ +QE+ M EK + + + L +V +L
Sbjct: 2405 QERISELEIINSSFENILQEKEQEKVQMK----EKSSTAMEMLQTQLKELNERVAALHND 2460
Query: 1723 LDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
+ A + S E L++++ Q+ + LD+ + + L +S G + +V
Sbjct: 2461 QEACKAKEQNLSSQVECLELEKAQL----------LQGLDEAKNNYIVLQSSVNGLIQEV 2510
Score = 148 bits (374), Expect = 5e-35
Identities = 247/1137 (21%), Positives = 489/1137 (43%), Gaps = 204/1137 (17%)
Query: 40 EGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQ 99
E ++ + ++ + + +H ++ + +++ L +++E +Q Q T
Sbjct: 1767 EDIHNLQLRVKETSNENLRLLH-VIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEAC 1825
Query: 100 LQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHD 159
++ +++ + LK L ++L Q + + S + H
Sbjct: 1826 IELEKI-VGELKKENSDLSEKLEYFSCDHQEL-----LQRVETSEGLNSDLEMHADKSSR 1879
Query: 160 DDMDFGDIISS-----QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+D+ GD ++ ++ + NE+SR+ SE H A +A E+ +
Sbjct: 1880 EDI--GDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEAD-------LEVVQT 1930
Query: 215 QNIIKEL-KQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHR-----EELSD-YEERIEE 267
+ + E +N+ + I + E+SV+ + Q E+ + ++LS+ +E+ +E
Sbjct: 1931 EKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQE 1990
Query: 268 LENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAEN 327
LE+ Q I+ +++ E + +Q L + E K L++K++ + K +
Sbjct: 1991 LESH-QSECLHCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSL 2049
Query: 328 DRDILRREQEQLNVEKRQIMEECENLKLECS-----KLQPSAVKQSDTMTEKERILAQSA 382
+ L + QLN EK +++E E+L+ S KL S ++ + + E L S+
Sbjct: 2050 TKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSS 2109
Query: 383 SVEEVFRLQQALSDAE-----NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQE 437
+ EEV +L++ + +E +L + +N LK ++E LE+E + +
Sbjct: 2110 TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN 2169
Query: 438 KEELQMSLLKLNNEYEVIKSTATRD-----------ISLDSELHDLRLNLEAKE---QEL 483
+E + + E E +K+ ++L SE +L ++ K+ EL
Sbjct: 2170 QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL 2229
Query: 484 NQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE------GDSIISKL-KQDL 536
++ +S ++L+ E E+ + Q +E +K + + K+ NE GD I K +Q L
Sbjct: 2230 DKLLSSFKSLLEEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSL 2289
Query: 537 NDEKKRVHQLED--DKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLN- 593
+ + HQL + +K+ E D +K+ + ++ ++ H L+ +VENL +L
Sbjct: 2290 DPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHA--DLLKGRVENLERELEI 2347
Query: 594 -KSQESNVSIQKENLE------------LKEHIRQNEEELSRIRNE---LMQSLNQDS-- 635
++ + + +++ EN + + + +R E ++ IR+E L L ++
Sbjct: 2348 ARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQER 2407
Query: 636 -------NSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED 688
NS+F++ L ++ + +V+ +++ + +E L LK++ NE++ D
Sbjct: 2408 ISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKEL-------NERVAALHND 2460
Query: 689 VRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKR----------LLEEAN- 737
E C A LS + VE L++EK ++ L AK L++E
Sbjct: 2461 Q----EACKAKEQNLSSQ----VECLELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVED 2512
Query: 738 ---KYEKTIEELSNARN-------LNTSALQLEHEHLIKLNQKKDME--IAELKKNIEQM 785
K EK EE+S +N L + Q+E EH + Q ++ EL++ I+ +
Sbjct: 2513 GKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVL 2572
Query: 786 DTDH---KETKDVLSSS---LEEQKQLTQLINKKEIFIEKLKERSSK---LQEELDKYSQ 836
+ + ++T +VL SS LE + +LT++ K F+EK+ + ++K LQ E+ + +Q
Sbjct: 2573 QSKNASLQDTLEVLQSSYKNLENELELTKM--DKMSFVEKVNKMTAKETELQREMHEMAQ 2630
Query: 837 AL---------RKNEI---LRQTIEEKDRSLGSMKE---ENNHLQEELE----------- 870
KN + L+ +EE S +KE EN+ L++ L+
Sbjct: 2631 KTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEG 2690
Query: 871 -----------RLRE-EQSRTAPVADP------------KTLDSVTELAS----EVSQLN 902
RL E E+ A + D + L S E S E+ L
Sbjct: 2691 KVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLEIDLLK 2750
Query: 903 TIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKD 962
+ KE L +K +I+E+ ++KM L+ + + KKE + + + + + + QL +
Sbjct: 2751 SSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQL----E 2806
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETE 1019
EE + LQK + Q+ Q +E+Q T +TKV L E K L + E
Sbjct: 2807 EEKEILQKELSQL--QAAQEKQKTGT-----VMDTKVDELTTEIKELKETLEEKTKE 2856
Score = 126 bits (317), Expect = 2e-28
Identities = 214/1007 (21%), Positives = 439/1007 (43%), Gaps = 162/1007 (16%)
Query: 12 LGQSLGQVGGSLASLTGQISNFTK-----DMLMEGTEEVEAELPDSRTKEIEAIHAILRS 66
L + L V L G++ +K D L E +E EL ++ E +H I +
Sbjct: 1949 LEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQS---ECLHCIQVA 2005
Query: 67 ENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQS 126
E E +K T+L + + ++ + T + +LQ E + L + L++Q+ +L
Sbjct: 2006 EAEVKEK--TELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIAQLNK 2063
Query: 127 AAQS-VPSGAGVPATTASSSFA-YGISHHPSAFHDDDMDFGDIISS-QQEINRLSNEVS- 182
+ V + A + S + +S A + +F +SS Q+E+++L +
Sbjct: 2064 EKELLVKESESLQARLSESDYEKLNVSKALEAALVEKGEFALRLSSTQEEVHQLRRGIEK 2123
Query: 183 ---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELK---QNRSQEIDDHQHEM 236
R+E++ HIA+ K + +N + K++N+ +EL+ +N+ I D ++
Sbjct: 2124 LRVRIEADEKKQLHIAEKLKERERENDSLKD--KVENLERELQMSEENQELVILDAENSK 2181
Query: 237 SVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ-----GGSGVIETDLSKIYEMQ 291
+ ++ Q + E++R + D E ENL +Q G ++ LS +
Sbjct: 2182 AEVETLKTQ-IEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLL 2240
Query: 292 KTIQVLQIE-KVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNV--------- 341
+ + +I+ K ES +E L++++K++N+ +++ D++I++ ++ L+
Sbjct: 2241 EEKEQAEIQIKEESKTAVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEEHQLR 2300
Query: 342 -------------EKRQI-----MEECEN---------------LKLECSKLQPSAVKQS 368
EK+Q+ ++E E+ L++ + + +A++
Sbjct: 2301 NSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEAE 2360
Query: 369 DTMTEKERILAQSASVEEVFR------------LQQALSDAENEIMRLSSLNQDNSLAED 416
++ E E + A+ + + R + ++ + E R+S L NS E+
Sbjct: 2361 NSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFEN 2420
Query: 417 NLKLKMRIEVLEKEKS-----LLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHD 471
L+ K + +V KEKS +L + +EL + L+N+ E K+ ++ +L S++
Sbjct: 2421 ILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKA---KEQNLSSQVEC 2477
Query: 472 LRLN----LEAKEQELNQSI---SEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNE 524
L L L+ ++ N I S LI E+E+ ++ ++ + + +K+Q+ Q+
Sbjct: 2478 LELEKAQLLQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQ- 2536
Query: 525 GDSIISKLKQDLNDE---KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKL 581
++SKL Q + K++ +L + +++ +++ V + K + L L + + L
Sbjct: 2537 ---LVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNASLQDTLEVLQSSYKNL 2593
Query: 582 EDKVE-------NLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNEL---MQSL 631
E+++E + V+++NK +Q+E E+ + + +EELS +N L +Q L
Sbjct: 2594 ENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLL 2653
Query: 632 NQD-------------SNSNFK---DTLLKEREAEVRNLKQNLSELE-QLNENLKKVAFD 674
++ NS K D + K++ + +++ ++E + +L+E KK
Sbjct: 2654 LEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL 2713
Query: 675 VKMENEKLVLACEDVRHQL---EECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKR 731
+ N++ + + R +L EECL+ LE ++ LK K E+ L A +
Sbjct: 2714 LLDTNKQYEVEIQTYREKLTSKEECLSSQK---LE----IDLLKSSKEELNNSLK-ATTQ 2765
Query: 732 LLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791
+LEE K + + N Q + + LIK ++ + E L+K + Q+ ++
Sbjct: 2766 ILEELKKTKMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEK 2825
Query: 792 TKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEK 851
K + + T++ KE EK KE E LDKY L +E L + E
Sbjct: 2826 QKTGTVMDTKVDELTTEIKELKETLEEKTKE----ADEYLDKYCSLLISHEKLEKAKEML 2881
Query: 852 DRSLGSMKEENNHLQEELERLREEQSRTAP-----VADPKTLDSVTE 893
+ + + + + ++ SR +P V P + SVTE
Sbjct: 2882 ETQVAHLCSQQS----------KQDSRGSPLLGPVVPGPSPIPSVTE 2918
Score = 113 bits (282), Expect = 2e-24
Identities = 187/1024 (18%), Positives = 423/1024 (41%), Gaps = 148/1024 (14%)
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
L+ +L++L++E+ + +L S + L K+ +E E K ++ +NQ
Sbjct: 23 LEGQLDKLKKEKQQRQ-----------FQLDSLEAALQKQKQKVENE-KTEGTNLKRENQ 70
Query: 925 SKMQLLQSLQEQKKEMD-EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEER 983
M++ +SL++ K+++ E + + Q+N QL K ++I+ L++ +++ K++L +
Sbjct: 71 RLMEICESLEKTKQKISHELQVKESQVNFQEGQLNSGK-KQIEKLEQELKRCKSELERSQ 129
Query: 984 QDIQTDNSDI--------FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLL 1035
Q Q+ + + T + +GS+ DL K + + V+ K E E+K L
Sbjct: 130 QAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDL-KEKYNKEVEERKRLEAEVKAL 188
Query: 1036 NEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHT-------------- 1081
K S T ++ ++ + + + + +SS S
Sbjct: 189 QAKKASQTLPQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQRTPIRRDFSASYFSG 248
Query: 1082 -QDVVYLQQQLQAYAMEREKVFA-------VLNEKTRENSHLKTEYHKMMDIVAAKEAAL 1133
Q+V + LQ + F +L++ +N L+ + +++ + E +
Sbjct: 249 EQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELELRLQGHEKEM 308
Query: 1134 IKLQDENKKLSTRFESSGQDMF-RETIQNLSR--IIR------EKDIEIDALSQKCQTLL 1184
++ ++L + E + ++ +E + N R ++R + + AL QK + L
Sbjct: 309 KGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLT 368
Query: 1185 AVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQE 1244
L E+ + Q K+K++ K+ +E + + Q + E Q++
Sbjct: 369 EDLSCQRQNAESARCSLEQ---------KIKEKEKEFQEELSRQQRSFQTLDQECIQMKA 419
Query: 1245 ELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDL 1304
L Q Q + ++ LQ + L +Q E L+ F Q+L + + + ++
Sbjct: 420 RLTQELQQA---KNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENE 476
Query: 1305 LLGKLDIISPQLSSASLLTPQSAE--CLRASKSEVLSESSELLQQELEELRKSLQEKDAT 1362
L ++ + + + + Q A C ++ + + + Q EE++ ++
Sbjct: 477 LRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETM 536
Query: 1363 IRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQ 1422
+R LQE ++ +S+ E+ + L++++D Q LLK+++ I+ +D+
Sbjct: 537 LRDLQEKINQQENSLTL---------EKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDK 587
Query: 1423 LLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQAL 1482
L + + ++ EL ++ LKE + K ENEK++ E+E + L
Sbjct: 588 LSKTEKESKALLSALELKKKEYEELKEEKTLFSC----WKSENEKLLTQM---ESEKENL 640
Query: 1483 QETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM------Q 1536
Q L+ ++ + H E+ E + + E+ L N + S Q
Sbjct: 641 QSKINHLETCLKTQQIKSHEYNERVRTLEM----DRENLSVEIRNLHNVLDSKSVEVETQ 696
Query: 1537 EKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYT 1596
+ + Q++ + QK++EN L+ +L + +L+ L N +++ + Y
Sbjct: 697 KLAYMELQQKAEFSDQKHQKEIENMCLKTS--QLTGQVEDLEHKLQLLSNEIMDKDRCY- 753
Query: 1597 REALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQL-----NVVSKQ 1651
+D A+ +L+ K ++ + N HQ S+ Q + N++ +Q
Sbjct: 754 ------QDLHAEYESLRDLLKSK---DASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQ 804
Query: 1652 -------------RDETALQLSVSQEQVKQYALSLANLQMVLEHFQQ--EEKAMYSAELE 1696
D++ ++ Q +V SL + + + Q+ EE E+E
Sbjct: 805 GSMPSERSECRLEADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKGEIE 864
Query: 1697 KQ--------KQLIAEWKKNAENLEGKVISLQECLDEANAALDSASR----LTEQLDVKE 1744
+ + +AE + L+ + Q + E +AL++ + L ++++ ++
Sbjct: 865 ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENKEKELQLLNDKVETEQ 924
Query: 1745 EQIEELKRQNELRQEMLDDVQ----------KKLMSLANSSEGKVDKVLMRNLFIGHFHT 1794
+I+ELK+ N L ++ L ++Q K++ S+ + ++ +++++ N + +
Sbjct: 925 AEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINA 984
Query: 1795 PKNQ 1798
NQ
Sbjct: 985 SLNQ 988
Score = 87.4 bits (215), Expect = 1e-16
Identities = 155/765 (20%), Positives = 306/765 (40%), Gaps = 98/765 (12%)
Query: 1067 EIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV 1126
+IQ L ++ + Q A++++K V NEKT E ++LK E ++M+I
Sbjct: 19 KIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQ-KVENEKT-EGTNLKRENQRLMEIC 76
Query: 1127 AAKEAALIKLQDEN--KKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLL 1184
+ E K+ E K+ F+ + ++ I+ L + ++ E++ Q Q+
Sbjct: 77 ESLEKTKQKISHELQVKESQVNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSAD 136
Query: 1185 AVLQTSSTGNE--------AGGVNSNQFEEL-------LQERDKLKQQVKKMEEWKQQVM 1229
L +T + + + +++E+L ++ER +L+ +VK ++ K
Sbjct: 137 VSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQT 196
Query: 1230 TTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELA 1289
M H HQ + V S Q + S Q ++F
Sbjct: 197 LPQATMNHRDIAR----HQASSSVF------SWQQEKTPSHLSSNSQRTPIRRDFSASYF 246
Query: 1290 QVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQEL 1349
+ + +T L +GK D S ++S +P + L+A E+ ++ +EL
Sbjct: 247 SGEQEVTPSRST--LQIGKRDANSSFFDNSS--SPHLLDQLKAQNQELRNKINEL----- 297
Query: 1350 EELRKSLQEKD--ATIRTLQENNHRLSDSIAATSELE------RKEHEQTDSEIKQLKEK 1401
ELR EK+ + QE +L + E E R E +T ++ Q K
Sbjct: 298 -ELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQASTK 356
Query: 1402 QDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIL-ILEMDIGK 1460
L++ LK+ + + S+ + K+ E E Q + ++R L+ + +
Sbjct: 357 YTALEQKLKKLTEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQ 416
Query: 1461 LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQG 1520
+K ++ + + + + LQ K + + ++ E K+K EQ + Q
Sbjct: 417 MKA---RLTQELQQAKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAF-QASQI 472
Query: 1521 KTGELNQLLNAVKSMQE--KTVVFQQERDQVMLALKQKQMEN--TALQNEVQRLRDKEFR 1576
K EL + + +K K+ Q+ R+ L + K ++ QN + ++ K
Sbjct: 473 KENELRRSMEEMKKENNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTS 532
Query: 1577 SNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASV 1636
L L+ + + E+S T E KL+ V LE++ S + ++ H
Sbjct: 533 QETMLRDLQEKINQQENSLTLE---------KLKLAVADLEKQRDCSQDLLKKREHH--- 580
Query: 1637 QVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELE 1696
+E L ++L SK E+ LS + + K+Y +EEK ++S
Sbjct: 581 -IEQLNDKL---SKTEKESKALLSALELKKKEY------------EELKEEKTLFSCWKS 624
Query: 1697 KQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNEL 1756
+ ++L+ + + ENL+ K+ L+ CL T+Q +K + E R E+
Sbjct: 625 ENEKLLTQMESEKENLQSKINHLETCLK------------TQQ--IKSHEYNERVRTLEM 670
Query: 1757 RQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHE 1801
+E L + L ++ +S +V+ + + + +Q+H+
Sbjct: 671 DRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQ 715
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 190 bits (482), Expect = 1e-47
Identities = 337/1618 (20%), Positives = 645/1618 (39%), Gaps = 238/1618 (14%)
Query: 252 RRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQI--EKVEST---- 305
RR +++L+D +ELE L + + E D ++I MQ+ I L + EK ++
Sbjct: 217 RRLKKQLADERSNRDELELELAENRKLLTEKD-AQIAMMQQRIDRLALLNEKQAASPLEP 275
Query: 306 KKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAV 365
K++E+L DK + + +L L+ E+ Q++ + Q+ EE +L + +
Sbjct: 276 KELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEENGDLSFKLREFASHLQ 335
Query: 366 KQSDTMTE--KERILAQSASVEEVFRLQQALSDA---------ENEIM--RLSSLN---- 408
+ D + E +E A +E+ +L++ LS A +NEI+ +LS L
Sbjct: 336 QLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKCLEEKNEILQGKLSQLEEHLS 395
Query: 409 --QDN-----------------------SLAEDNLKLKMRIEVLEKEK-----SLLSQ-- 436
QDN +LA +N +L+ R+E+LE E+ LL++
Sbjct: 396 QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLETERGQQEAKLLAERG 455
Query: 437 --EKEELQMSLLKLNNEYEVIK-STATRDISLDSELHDLRL-----NLEAKEQELNQSIS 488
E+E+ Q+S L + + + S A ++ S+ H RL +L ++ LN +I
Sbjct: 456 HFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAHGARLTAQVASLTSELTTLNATIQ 515
Query: 489 EKETLIAEIEELDRQNQEATKHMILIKDQLSK-QQNEGDSIISKLKQDLNDEKKRVHQLE 547
+++ +A +++ ++ Q + ++Q S+ +++ + + S LKQ K+ + E
Sbjct: 516 QQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQVEQLSSSLKQKEQQLKEVAEKQE 575
Query: 548 DDKMDITKELDVQKEK----LIQSEVALNDLHLTKQKLEDKVENLVDQL-------NKSQ 596
+ D ++L E+ L + + AL L +++ K+E L QL + +Q
Sbjct: 576 ATRQDHAQQLATAAEEREASLRERDAALKQLEALEKEKAAKLEILQQQLQVANEARDSAQ 635
Query: 597 ESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQ 656
S Q+E EL + + + + R E ++ Q + + L+ + + ++
Sbjct: 636 TSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQVAELELQ---LRSEQQKATEKER 692
Query: 657 NLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKM 716
E +QL E L+ + +K+ L LEE ++L E ++VE K
Sbjct: 693 VAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQHKR 752
Query: 717 EKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIA 776
E+ E+E E K E +++L A T L+ E + + E
Sbjct: 753 ERKELEEERAGRK--------GLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECE 804
Query: 777 ELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQ 836
+L K + ++ S +E+ Q + ++ + LKE K ++EL + +
Sbjct: 805 QLVKEVAAW-------RERYEDSQQEEAQYGAMFQEQ---LMTLKEECEKARQELQEAKE 854
Query: 837 ALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTL--DSVTEL 894
+ E + + R + E + +L L++++E++ R +AD + + +
Sbjct: 855 KVAGIESHSEL--QISRQQNELAELHANLARALQQVQEKEVRAQKLADDLSTLQEKMAAT 912
Query: 895 ASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATH 954
+ EV++L T+ +K E Q + +L++ E+ + +
Sbjct: 913 SKEVARLETLV----------RKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCS 962
Query: 955 TQLFLE-KDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDL 1013
TQ L+ + E + + +E+++ L E + Q + QE +V L E G + DL
Sbjct: 963 TQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQ--QEREVARLTQERGRAQADL 1020
Query: 1014 SKAETERLVKGIKERELEIKL---LNEKNI---SLTKQIDQLSKDEVGKLTQIIQQKDLE 1067
+ + R ELE++L LNE+ + +L + + ++ GK ++ + + LE
Sbjct: 1021 ALEKAAR-------AELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLE 1073
Query: 1068 IQALHARISSTSH-TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIV 1126
A+I Q V L++QL E +E + + V
Sbjct: 1074 A----AQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEV 1129
Query: 1127 AAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEI--DALSQKCQTLL 1184
+ E K Q++ L E+ + SR R+ +E L +K Q L
Sbjct: 1130 SKLEQQCQKQQEQADSLERSLEA----------ERASRAERDSALETLQGQLEEKAQEL- 1178
Query: 1185 AVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHES---AQ 1241
G+ + S Q EL R K++ K +EWK QV Q + ++ +
Sbjct: 1179 --------GHSQSALASAQ-RELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS 1229
Query: 1242 LQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNT 1301
L+EE+ L QVL + +L+ L+ + + KL+
Sbjct: 1230 LEEEVSILNRQVLEKEGESKELK----RLVMAESEKSQKLEE------------------ 1267
Query: 1302 KDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSE------SSELLQQELEELRKS 1355
+L ++ + +S S + + LR + E +SE L+QEL +
Sbjct: 1268 ------RLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAER 1321
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+E ++ QE + +++ + EH T + + +L + + Q+L E+
Sbjct: 1322 AEELGQELKAWQEKFFQKEQALSTL----QLEHTSTQALVSELLPAKHLCQQLQAEQAAA 1377
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKL------KGENEKIV 1469
K ++L E +QA L+ +L + ++G+L E E+
Sbjct: 1378 EKRHREEL--------------EQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTA 1423
Query: 1470 ETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLL 1529
+ R ++ Y K +L E E + E+A Q L+ + + Q L
Sbjct: 1424 QQLRAEKASYAEQLSMLKKAHGLLAE---ENRGLGERANLGRQFLEVELDQAREKYVQEL 1480
Query: 1530 NAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLL 1589
AV++ E LA Q++ ++TA + EV + + + ER R
Sbjct: 1481 AAVRADAE-----------TRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQR--FQ 1527
Query: 1590 ESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQ-ASVQVESLQEQLNVV 1648
E T + E + + K+V L +KL S A + + +VQ + + Q
Sbjct: 1528 EERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQ 1587
Query: 1649 SKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKN 1708
Q LQ +SQ K+ A LQM + K + EL++Q + + + +K
Sbjct: 1588 RLQAQLNELQAQLSQ---KEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKE 1644
Query: 1709 AENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQK 1766
+ L + L L +A A + L Q+ L+ Q + L D+ K
Sbjct: 1645 NKELRAEAERLGHELQQAGLKTKEAEQTCRHLTA---QVRSLEAQVAHADQQLRDLGK 1699
Score = 166 bits (421), Expect = 2e-40
Identities = 307/1525 (20%), Positives = 616/1525 (40%), Gaps = 232/1525 (15%)
Query: 244 QQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVE 303
QQ++ ++ + ++ + E +ELE L + E+ +++E K Q L+ EK +
Sbjct: 255 QQRIDRLALLNEKQAASPLEP-KELEELRDKN-----ESLTMRLHETLKQCQDLKTEKSQ 308
Query: 304 STKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPS 363
+K+ QL ++ D++ KL + L+ +L E + +E + + K +
Sbjct: 309 MDRKINQLSEENGDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSA 368
Query: 364 AVKQSDTMTEKERILAQSASV--EEVFRLQ----QALSDAENEIMRLSSLNQDNS-LAED 416
A++ + EK IL S E + +LQ Q + ++++L +L Q+ + LA +
Sbjct: 369 ALQDKKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAAN 428
Query: 417 NLKLKMRIEVLEKEKS-----LLSQ----EKEELQMSLLKLNNEYEVIK-STATRDISLD 466
N +L+ R+E+LE E+ LL++ E+E+ Q+S L + + + S A ++
Sbjct: 429 NTQLQARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQA 488
Query: 467 SELHDLRL-----NLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQ 521
S+ H RL +L ++ LN +I +++ +A +++ ++ Q + ++Q S+
Sbjct: 489 SQAHGARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQG 548
Query: 522 -QNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEK----LIQSEVALNDLHL 576
+++ + + S LKQ K+ + E + D ++L E+ L + + AL L
Sbjct: 549 LRHQVEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEA 608
Query: 577 TKQKLEDKVENLVDQL-------NKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQ 629
+++ K+E L QL + +Q S Q+E EL + + + + R E +
Sbjct: 609 LEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHE 668
Query: 630 SLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDV 689
+ Q + + +++ E + Q +L++ + LK+ K E+ D
Sbjct: 669 AQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADA 728
Query: 690 RHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
+ + C++ +L E ++VE K E+ E+E E K E +++L A
Sbjct: 729 LEEQQRCIS---ELKAETRSLVEQHKRERKELEEERAGRKG--------LEARLQQLGEA 777
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQL 809
T L+ E + + E +L K + +++++ +E+ Q +
Sbjct: 778 HQAETEVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQ-------QEEAQYGAM 830
Query: 810 INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEEL 869
++ + LKE K ++EL + + + E + + R + E + +L L
Sbjct: 831 FQEQ---LMTLKEECEKARQELQEAKEKVAGIESHSEL--QISRQQNELAELHANLARAL 885
Query: 870 ERLREEQSRTAPVADPKTL--DSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKM 927
++++E++ R +AD + + + + EV++L T+ +K E Q +
Sbjct: 886 QQVQEKEVRAQKLADDLSTLQEKMAATSKEVARLETLV----------RKAGEQQETASR 935
Query: 928 QLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE-EIKSLQKTIEQIKTQLHEERQDI 986
+L++ E+ + + TQ L+ E E + + +E+++ L E +
Sbjct: 936 ELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQ 995
Query: 987 QTDNSDIFQETKVQSLNIENGSEKHDLS-----KAETE-RLVKGIKERELEIKLLNE--- 1037
Q + QE +V L E G + DL+ +AE E RL + E+ +E L E
Sbjct: 996 QEERGQ--QEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALA 1053
Query: 1038 --------KNISLTK-------QIDQLS--KDEVGKLTQIIQQKDLE------------- 1067
K+ L K QI +L + V +L + + +K+ E
Sbjct: 1054 HALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAG 1113
Query: 1068 --------IQALHARISSTSHTQDVVYLQQQLQAYAMER----------------EKVFA 1103
++AL A +S +QQ QA ++ER E +
Sbjct: 1114 RTEPTGPKLEALRAEVSKLEQQCQ----KQQEQADSLERSLEAERASRAERDSALETLQG 1169
Query: 1104 VLNEKTRENSHLKTEYHKMMDIVAAKEAAL---IKLQDENKKLSTRFESSGQ------DM 1154
L EK +E H ++ +AA + K +DE K R +
Sbjct: 1170 QLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISS 1229
Query: 1155 FRETIQNLSRIIREKDIEIDAL----------SQKCQTLLAVLQTSSTGNEAGGVNSNQF 1204
E + L+R + EK+ E L SQK + L +LQ + N A +
Sbjct: 1230 LEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS- 1288
Query: 1205 EELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQ 1264
L +E L+++ +K + + + + + +L +EL Q + S LQ
Sbjct: 1289 -ALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQ 1347
Query: 1265 VDYTGLI----------------------------QSYEQNETKLKNFGQELAQVQHSIG 1296
+++T + EQ++ EL + Q +G
Sbjct: 1348 LEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREELEQSKQAAGGLRAELLRAQRELG 1407
Query: 1297 QLCNTKDLLLGK----LDIISPQLSSASLLTP-QSAECLRASKSEVLSESSEL----LQQ 1347
+L + + + + + + S A L+ + A L A ++ L E + L L+
Sbjct: 1408 ELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEV 1467
Query: 1348 ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQ- 1406
EL++ R+ ++ A +R +D+ +E++R E + T E++ + K + +
Sbjct: 1468 ELDQAREKYVQELAAVR---------ADAETRLAEVQR-EAQSTARELEVMTAKYEGAKV 1517
Query: 1407 KLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERI---LILEMDIGKLKG 1463
K+L+E+ + + T +V + E+ ++ T E + L K++
Sbjct: 1518 KVLEERQ--------RFQEERQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQ 1569
Query: 1464 ENEKIVETYRGK-ETEYQALQETNMKFSMMLREKEFECHSMK---EKALAFEQLLKEKEQ 1519
+ K V+ G+ + E Q LQ + L +KE K EKA K++ Q
Sbjct: 1570 QKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQ 1629
Query: 1520 G---KTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFR 1576
+ L QL K ++ + E Q L K+ + L +V+ L +
Sbjct: 1630 ELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHLTAQVRSLEAQVAH 1689
Query: 1577 SNQELERLRNHLLESEDSYTREALA 1601
++Q+L L + ++ +RE A
Sbjct: 1690 ADQQLRDLGKFQVATDALKSREPQA 1714
Score = 164 bits (414), Expect = 1e-39
Identities = 321/1599 (20%), Positives = 645/1599 (40%), Gaps = 238/1599 (14%)
Query: 260 DYEERI---EELENLLQQGG-----SGVIETDLSK-IYEMQKTIQVLQIEKVESTKKMEQ 310
D+E+ + E+LEN LQ+ S +LS ++ ++ I+ L+++KV S+
Sbjct: 136 DHEDGLNLNEDLENFLQKAPVPSTCSSTFPEELSPPSHQAKREIRFLELQKVASSSSGNN 195
Query: 311 LEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDT 370
S A DIL+ Q Q+ K+Q+ +E N +L+ +
Sbjct: 196 FLSG--------SPASPMGDILQTPQFQMRRLKKQLADERSNR----DELELELAENRKL 243
Query: 371 MTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLE-K 429
+TEK+ AQ A +++ I RL+ LN+ K LE K
Sbjct: 244 LTEKD---AQIAMMQQ-------------RIDRLALLNE-----------KQAASPLEPK 276
Query: 430 EKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISE 489
E L + E L M L +E +K + DL+ ++++NQ E
Sbjct: 277 ELEELRDKNESLTMRL------HETLK-----------QCQDLKTEKSQMDRKINQLSEE 319
Query: 490 KETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDD 549
L ++ E H+ ++D L++ E + + +K + D
Sbjct: 320 NGDLSFKLREF-------ASHLQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQD 372
Query: 550 KMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLEL 609
K + ++ ++ + KL Q E L+ L + + +V V QL ++ ++ N +L
Sbjct: 373 KKCLEEKNEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQL 432
Query: 610 KEHIRQNEEELSRIRNELMQSLNQ-DSNSNFKDTLLKEREAEVRNLKQNLSELEQLNE-N 667
+ + E E + +L+ + +L+ + ++ + NL Q ELEQ ++ +
Sbjct: 433 QARVEMLETERGQQEAKLLAERGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH 492
Query: 668 LKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNT-IVETLKMEKG------- 719
++ V +L ++ Q +E LAG Q + EK + +TL+ ++
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQE-LAGLKQQAKEKQAQLAQTLQQQEQASQGLRH 551
Query: 720 ---EIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEH---------EHLIKL 767
++ + L +++L E A K E T ++ +A+ L T+A + E + L L
Sbjct: 552 QVEQLSSSLKQKEQQLKEVAEKQEATRQD--HAQQLATAAEEREASLRERDAALKQLEAL 609
Query: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 827
++K ++ L++ ++ + + ++ + E+ +L++ + + + +E ++ +
Sbjct: 610 EKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEA 669
Query: 828 QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADP-- 885
Q ++ + LR + Q EK+R + +E + LQE+L+ L+E T +
Sbjct: 670 QAQVAELELQLRSEQ---QKATEKER----VAQEKDQLQEQLQALKESLKVTKGSLEEEK 722
Query: 886 -KTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQL---LQSLQEQKKEMD 941
+ D++ E +S+L L E+ K +K +E++ + L LQ L E +
Sbjct: 723 RRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQAET 782
Query: 942 EF--RYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKV 999
E R E M A HT + E + L K + + + +E+ Q + +FQE
Sbjct: 783 EVLRRELAEAMAAQHTA-----ESECEQLVKEVAAWRER-YEDSQQEEAQYGAMFQE--- 833
Query: 1000 QSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQ 1059
Q + ++ EK E + V GI E E+++ ++N ++ +L + + + Q
Sbjct: 834 QLMTLKEECEKARQELQEAKEKVAGI-ESHSELQISRQQN-----ELAELHAN-LARALQ 886
Query: 1060 IIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEY 1119
+Q+K++ Q L D+ LQ+++ A + E ++ ++ + + E
Sbjct: 887 QVQEKEVRAQKL---------ADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASREL 937
Query: 1120 HKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQK 1179
K ++ ++ Q + ST+ +Q + R + E++ L
Sbjct: 938 VKEPARAGDRQPEWLEEQQGRQFCSTQ----------AALQAMEREAEQMGNELERLRA- 986
Query: 1180 CQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHES 1239
A++++ E G + L QER + + + + + ++ +QN +E
Sbjct: 987 -----ALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEMRLQNALNEQ 1041
Query: 1240 AQLQEELHQLQAQVLVDSDNNSKLQVDYTGL----IQSYEQNETKLKNFGQELAQVQHSI 1295
L + A L + + + GL I+ E+ +K ++LA+ +
Sbjct: 1042 RVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEH 1101
Query: 1296 GQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV------LSESSELLQQEL 1349
+ G+ + P+L E LRA S++ E ++ L++ L
Sbjct: 1102 ASGSGAQSEAAGRTEPTGPKL-----------EALRAEVSKLEQQCQKQQEQADSLERSL 1150
Query: 1350 EELRKSLQEKDATIRTLQ----ENNHRLSDSIAATSELERK---------EHEQTDSEIK 1396
E R S E+D+ + TLQ E L S +A + +R+ +H + + E K
Sbjct: 1151 EAERASRAERDSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWK 1210
Query: 1397 Q--LKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILIL 1454
+ +Q+ +K + L+SS E + +N L ++ + +R+++
Sbjct: 1211 AQVARGRQEAERK-------------NSLISSLEEEVSILNRQVLEKEGESKELKRLVMA 1257
Query: 1455 EMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLL 1514
E + +++K+ E R + E + + S LRE+ EK + L
Sbjct: 1258 ESE------KSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENL 1311
Query: 1515 KEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKE 1574
+++ + +L +K+ QEK FQ+E+ AL Q+E+T+ Q V L +
Sbjct: 1312 RQELTSQAERAEELGQELKAWQEK--FFQKEQ-----ALSTLQLEHTSTQALVSELLPAK 1364
Query: 1575 FRSNQ----ELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNA--ME 1628
Q + + H E E S AA A+L + L E + E
Sbjct: 1365 HLCQQLQAEQAAAEKRHREELEQSKQ----AAGGLRAELLRAQRELGELIPLRQKVAEQE 1420
Query: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSL-ANLQMVLEHFQQEE 1687
+ Q + S EQL+++ K A + E+ L L E + QE
Sbjct: 1421 RTAQQLRAEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQEL 1480
Query: 1688 KAMYSAELEKQKQLIAEWKKNAENLEGKVISLQ----ECLDEANAALDSASRLTEQLDVK 1743
A+ + + ++ E + A LE + + L+E + +LT Q+
Sbjct: 1481 AAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQV--- 1537
Query: 1744 EEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
EQ+E +R+ + + ++++ KKL +S+ + K+
Sbjct: 1538 -EQLEVFQRE---QTKQVEELSKKLADSDQASKVQQQKL 1572
Score = 157 bits (396), Expect = 1e-37
Identities = 302/1461 (20%), Positives = 594/1461 (40%), Gaps = 207/1461 (14%)
Query: 16 LGQVGGSLASLTGQISNFTKDMLMEGTE---EVEAELPDSRTKEIEAIHAILRSENERLK 72
L Q+ +L LT + S T++ L + + E+ A L D + L +NE L+
Sbjct: 334 LQQLQDALNELTEEHSKATQEWLEKQAQLEKELSAALQDKKC---------LEEKNEILQ 384
Query: 73 KLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVP 132
+ LEE Q++ + ++ +++ LK L +LQ+ + +
Sbjct: 385 GKLSQLEEHLS----QLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQLQARVEMLE 440
Query: 133 SGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISS-QQEINRLSNEVSRLE--SEVG 189
+ G + + F ++ +I+ Q I+ LS LE S+
Sbjct: 441 TERGQQEAKLLAERGH--------FEEEKQQLSSLITDLQSSISNLSQAKEELEQASQAH 492
Query: 190 HWRHIAQ----TSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQ 245
R AQ TS+ + + Q + +L + ++ K+ ++Q Q + Q Q
Sbjct: 493 GARLTAQVASLTSELTTLNATIQQQDQELAGLKQQAKEKQAQLAQTLQQQEQASQGLRHQ 552
Query: 246 --KLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVE 303
+L+ ++ ++L + E+ E Q + E + + E ++ L+ + E
Sbjct: 553 VEQLSSSLKQKEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALKQLEALEKE 612
Query: 304 STKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN--VEKRQ-----IMEECENLKLE 356
K+E L+ +++ N+ SA+ +RE+ +L+ VE+ Q +E + +
Sbjct: 613 KAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQHEAQAQ 672
Query: 357 CSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAED 416
++L+ + TEKER+ + ++E QAL E+ + SL ++ A D
Sbjct: 673 VAELELQLRSEQQKATEKERVAQEKDQLQEQL---QALK--ESLKVTKGSLEEEKRRAAD 727
Query: 417 NLKLKMRI--EVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL----DSELH 470
L+ + R E+ + +SL+ Q K E + +L E K R L +E
Sbjct: 728 ALEEQQRCISELKAETRSLVEQHKRERK----ELEEERAGRKGLEARLQQLGEAHQAETE 783
Query: 471 DLRLNLEAKEQELNQSISEKETLIAEI----EELDRQNQEATKHMILIKDQLSKQQNEGD 526
LR L + + SE E L+ E+ E + QE ++ + ++QL + E
Sbjct: 784 VLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLKEE-- 841
Query: 527 SIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKV- 585
K +Q+L + K++V +E EL + +++ +E+ N +Q E +V
Sbjct: 842 --CEKARQELQEAKEKVAGIESH-----SELQISRQQNELAELHANLARALQQVQEKEVR 894
Query: 586 -ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLL 644
+ L D L+ QE + KE L+ +R+ E+ EL++ + + + L
Sbjct: 895 AQKLADDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPAR-AGDRQPEWLE 953
Query: 645 KEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLS 704
+++ + + + L +E+ E E++ E +R L E +
Sbjct: 954 EQQGRQFCSTQAALQAMER--------------EAEQMGNELERLRAALMESQGQQQEER 999
Query: 705 LEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHL 764
++ V L E+G +A+L K E E ++ N + + + LQ H
Sbjct: 1000 GQQEREVARLTQERGRAQADLALEKAARAE----LEMRLQNALNEQRVEFATLQEALAHA 1055
Query: 765 IKLNQKKDMEIAELK-------KNIEQMDTDHKETKDVL----------SSSLEEQKQLT 807
+ + KD E+A+L+ K +E++ K+ K+ L S + E T
Sbjct: 1056 LTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRT 1115
Query: 808 QLINKK----EIFIEKLKERSSKLQEELDKYSQALRKN-----------EILRQTIEEKD 852
+ K + KL+++ K QE+ D ++L E L+ +EEK
Sbjct: 1116 EPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKA 1175
Query: 853 RSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
+ LG + Q EL R + + A+ + V E + N++ LEEE+
Sbjct: 1176 QELGHSQSALASAQRELAAFRTKVQDHSK-AEDEWKAQVARGRQEAERKNSLISSLEEEV 1234
Query: 913 K-HHQKIIEDQNQSK--MQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKD----EEI 965
+++++E + +SK +L+ + E+ ++++E + A+++ E+ EE+
Sbjct: 1235 SILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEV 1294
Query: 966 KSLQKTIEQIKTQLHEERQDIQTD---NSDIFQETKV---QSLNIENGSEKHDLSKAETE 1019
+SL++ E+ + RQ++ + ++ QE K + E L T+
Sbjct: 1295 QSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQ 1354
Query: 1020 RLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTS 1079
LV +LL K++ Q +Q + ++ + + ++Q L A
Sbjct: 1355 ALVS---------ELLPAKHLCQQLQAEQAAAEK--RHREELEQSKQAAGGLRA------ 1397
Query: 1080 HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDE 1139
+++ Q++L R+KV E+ R L+ E + ++ + A L +E
Sbjct: 1398 ---ELLRAQRELGELIPLRQKV----AEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEE 1450
Query: 1140 NKKLSTRFESSGQ------DMFRET-IQNLSRIIREKDIEIDALSQKCQTLLAVLQTSST 1192
N+ L R Q D RE +Q L+ + + + + + ++ Q+ L+ +
Sbjct: 1451 NRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLAEVQREAQSTARELEVMTA 1510
Query: 1193 GNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQ 1252
E V ++L+ER + +++ +K+ +Q ++ Q E + EEL ++
Sbjct: 1511 KYEGAKV------KVLEERQRFQEERQKLTAQVEQ----LEVFQREQTKQVEEL----SK 1556
Query: 1253 VLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDII 1312
L DSD SK+Q Q+L VQ G+ L +L+ +
Sbjct: 1557 KLADSDQASKVQ--------------------QQKLKAVQAQGGESQQEAQRLQAQLNEL 1596
Query: 1313 SPQLSSASLLTPQSAE--CLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENN 1370
QLS Q+AE L+ K++ ++ + QEL+E +SL++ + L+
Sbjct: 1597 QAQLSQKE----QAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEA 1652
Query: 1371 HRLSDSIAATSELERKEHEQT 1391
RL + L+ KE EQT
Sbjct: 1653 ERLGHELQQAG-LKTKEAEQT 1672
Score = 150 bits (380), Expect = 9e-36
Identities = 257/1298 (19%), Positives = 528/1298 (40%), Gaps = 151/1298 (11%)
Query: 602 IQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+Q +++ +Q +E S R+EL L ++ LL E++A++ ++Q + L
Sbjct: 209 LQTPQFQMRRLKKQLADERSN-RDELELELAENRK------LLTEKDAQIAMMQQRIDRL 261
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTI---VETLKMEK 718
LNE + K E E+L E + +L E L L EK+ + + L E
Sbjct: 262 ALLNEKQAASPLEPK-ELEELRDKNESLTMRLHETLKQCQDLKTEKSQMDRKINQLSEEN 320
Query: 719 GEIEAELCWAKKRLLEEANKYEKTIEELSNARN--LNTSALQLEHEHLIKLNQKKDME-- 774
G++ +L L + + + EE S A L A QLE E L KK +E
Sbjct: 321 GDLSFKLREFASHLQQLQDALNELTEEHSKATQEWLEKQA-QLEKELSAALQDKKCLEEK 379
Query: 775 -------IAELKKNIEQMDTDHKETK-----DVLSSSLEEQKQLTQLINKKEIFIEKLKE 822
+++L++++ Q+ + + K DVL +Q+ T N + L+
Sbjct: 380 NEILQGKLSQLEEHLSQLQDNPPQEKGEVLGDVLQLETLKQEAATLAANNTQ-----LQA 434
Query: 823 RSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPV 882
R L+ E + L R EE+ + L S+ + L + +EE + +
Sbjct: 435 RVEMLETERGQQEAKLLAE---RGHFEEEKQQLSSLITDLQSSISNLSQAKEELEQASQA 491
Query: 883 ADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 942
+ V L SE++ LN + ++E+ + + + + QL Q+LQ+Q++
Sbjct: 492 HGARLTAQVASLTSELTTLNATIQQQDQELAG---LKQQAKEKQAQLAQTLQQQEQASQG 548
Query: 943 FRYQHEQMNATHTQLFLEKDEEIKSL--------QKTIEQIKTQLHEERQDIQTDNSDIF 994
R+Q EQ++++ Q K++++K + Q +Q+ T E ++ ++ +
Sbjct: 549 LRHQVEQLSSSLKQ----KEQQLKEVAEKQEATRQDHAQQLATAAEEREASLRERDAALK 604
Query: 995 QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQL----- 1049
Q +++L E + K ++ + + + + + + + L++++++L
Sbjct: 605 Q---LEALEKEKAA-KLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVE 660
Query: 1050 -SKDEVGKLTQIIQQKDLEIQALHARISSTSH-TQDVVYLQQQLQAY---------AMER 1098
++ E + + + +L++++ + + Q+ LQ+QLQA ++E
Sbjct: 661 TARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSLEE 720
Query: 1099 EKVFA--VLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFR 1156
EK A L E+ R S LK E +++ + L + + K L R + G+
Sbjct: 721 EKRRAADALEEQQRCISELKAETRSLVEQHKRERKELEEERAGRKGLEARLQQLGEAHQA 780
Query: 1157 ETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQF-----EELLQER 1211
ET + L R + E +C+ L+ + E Q+ E+L+ +
Sbjct: 781 ET-EVLRRELAEAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQYGAMFQEQLMTLK 839
Query: 1212 DKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLI 1271
++ ++ ++++E K++V + + + ++ Q EL +L A + + +V L
Sbjct: 840 EECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQKLA 899
Query: 1272 QSYEQNETKLKNFGQELAQVQ---HSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAE 1328
+ K+ +E+A+++ G+ T L K + L Q +
Sbjct: 900 DDLSTLQEKMAATSKEVARLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQ 959
Query: 1329 -CLRASKSEVLSESSELLQQELEELRKSL------------QEKDATIRTLQENNHRLSD 1375
C + + + +E + ELE LR +L Q++ R QE +D
Sbjct: 960 FCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQAD 1019
Query: 1376 ---SIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTN 1432
AA +ELE + + + + Q+ L L EK+ K +L
Sbjct: 1020 LALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKE----GKDQELAKLRGLEAA 1075
Query: 1433 KVNENELLRQAVTNLKERILILEMDIGKLKGENEKI----------VETYRGKETEY-QA 1481
++ E E LRQ V LKE++ E + G + +E R + ++ Q
Sbjct: 1076 QIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQ 1135
Query: 1482 LQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVV 1541
Q+ + + R E E S E+ A E L + E+ K EL +A+ S Q +
Sbjct: 1136 CQKQQEQADSLERSLEAERASRAERDSALETLQGQLEE-KAQELGHSQSALASAQRELAA 1194
Query: 1542 FQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESE---DSYTRE 1598
F+ + A + + + + E +R +E+ L +LE E R
Sbjct: 1195 FRTKVQDHSKAEDEWKAQVARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRL 1254
Query: 1599 ALAAEDREAKLRKKVTVLEEKLVSSS--------------NAMENASHQASVQVESLQEQ 1644
+A ++ KL +++ +L+ + S+S ++ + + V E+L+++
Sbjct: 1255 VMAESEKSQKLEERLRLLQAETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQE 1314
Query: 1645 LNVVSKQRDETALQLSVSQEQVKQYALSLANLQ-------------MVLEHFQQEEKAMY 1691
L +++ +E +L QE+ Q +L+ LQ + +H Q+ +A
Sbjct: 1315 LTSQAERAEELGQELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQ 1374
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
+A ++ ++ + + K+ A L +++ Q L E L +++ +E ++L+
Sbjct: 1375 AAAEKRHREELEQSKQAAGGLRAELLRAQRELGE-------LIPLRQKVAEQERTAQQLR 1427
Query: 1752 RQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNLFI 1789
+ E L ++K LA + G ++ + F+
Sbjct: 1428 AEKASYAEQLSMLKKAHGLLAEENRGLGERANLGRQFL 1465
Score = 126 bits (317), Expect = 2e-28
Identities = 198/1026 (19%), Positives = 425/1026 (41%), Gaps = 124/1026 (12%)
Query: 43 EEVEAELPDSRTKEIEAIHAILRSEN---ERLKKLCTDLEEKHEASEIQIKQQSTSYRNQ 99
+E A+ D ++++A+ L+ E K+ D E+ + ++K ++ S Q
Sbjct: 690 KERVAQEKDQLQEQLQALKESLKVTKGSLEEEKRRAADALEEQQRCISELKAETRSLVEQ 749
Query: 100 LQQKEVEISHLKARQIALQDQLLKLQSAAQSVPS------GAGVPATTASSSFAYGISHH 153
+++ E+ +A + L+ +L +L A Q+ + A + S +
Sbjct: 750 HKRERKELEEERAGRKGLEARLQQLGEAHQAETEVLRRELAEAMAAQHTAESECEQLVKE 809
Query: 154 PSAFHD-------DDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
+A+ + ++ +G + Q+++ L E + E+ + K G ++
Sbjct: 810 VAAWRERYEDSQQEEAQYGAMF--QEQLMTLKEECEKARQELQEAKE-----KVAGIESH 862
Query: 207 DQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE 266
+ +I + QN + EL N ++ + Q + QKL + +E+++ + +
Sbjct: 863 SELQISRQQNELAELHANLARALQQVQEK-----EVRAQKLADDLSTLQEKMAATSKEVA 917
Query: 267 ELENLLQQGGSGVIETDLSKIYE----------------------MQKTIQVLQIEKVES 304
LE L+++ G + E Q +Q ++ E +
Sbjct: 918 RLETLVRKAGEQQETASRELVKEPARAGDRQPEWLEEQQGRQFCSTQAALQAMEREAEQM 977
Query: 305 TKKMEQLEDKIKDIN--KKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQP 362
++E+L + + ++ + +R++ R QE+ + +E+ +LE +LQ
Sbjct: 978 GNELERLRAALMESQGQQQEERGQQEREVARLTQERGRAQADLALEKAARAELEM-RLQN 1036
Query: 363 SAVKQ-----------SDTMTEKE---RILA-----QSASVEEVFRLQQALSDAENEIMR 403
+ +Q + +TEKE + LA ++A ++E+ L+Q + + ++ +
Sbjct: 1037 ALNEQRVEFATLQEALAHALTEKEGKDQELAKLRGLEAAQIKELEELRQTVKQLKEQLAK 1096
Query: 404 LSSLNQDNSLAEDNLKLKM-----RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKST 458
+ S A+ + ++E L E S L Q+ ++ Q L E +++
Sbjct: 1097 KEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERAS 1156
Query: 459 ATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQL 518
DS L L+ LE K QEL S S + E+ + Q+ +K K Q+
Sbjct: 1157 RAER---DSALETLQGQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQV 1213
Query: 519 SKQQNEGD---SIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEK---------LIQ 566
++ + E + S+IS L+++++ ++V + E + ++ + + + EK L+Q
Sbjct: 1214 ARGRQEAERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQ 1273
Query: 567 SEVALNDLHLTKQK--LEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIR 624
+E A N ++ L ++V++L ++ K + ++ ++++E E + +EL +
Sbjct: 1274 AETASNSARAAERSSALREEVQSLREEAEKQRVASENLRQELTSQAERAEELGQELKAWQ 1333
Query: 625 NELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLV- 683
+ Q S + T + +E+ K +L Q + + ++E K
Sbjct: 1334 EKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQL-QAEQAAAEKRHREELEQSKQAA 1392
Query: 684 --LACEDVRHQLEEC-LAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKR--LLEEANK 738
L E +R Q E L Q E+ + L+ EK +L KK LL E N+
Sbjct: 1393 GGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAHGLLAEENR 1452
Query: 739 YEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS 798
L NL L++E L+Q ++ + EL +T E + S
Sbjct: 1453 ------GLGERANLGRQFLEVE------LDQAREKYVQELAAVRADAETRLAEVQREAQS 1500
Query: 799 SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT----IEEKDRS 854
+ E + +T ++ K+ E + QEE K + + + E+ ++ +EE +
Sbjct: 1501 TARELEVMTAKYEGAKV---KVLEERQRFQEERQKLTAQVEQLEVFQREQTKQVEELSKK 1557
Query: 855 LGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLE---EE 911
L + + Q++L+ ++ + + A + + EL +++SQ EH + E+
Sbjct: 1558 LADSDQASKVQQQKLKAVQAQGGESQQEAQ-RLQAQLNELQAQLSQKEQAAEHYKLQMEK 1616
Query: 912 IKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKT 971
K H + QNQ + L+SL++ +KE E R + E++ Q L+ E ++ +
Sbjct: 1617 AKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQAGLKTKEAEQTCRHL 1676
Query: 972 IEQIKT 977
Q+++
Sbjct: 1677 TAQVRS 1682
Score = 117 bits (293), Expect = 1e-25
Identities = 191/930 (20%), Positives = 377/930 (40%), Gaps = 152/930 (16%)
Query: 64 LRSENERLKKLCTDLEEK----HEASEIQIKQQSTSYRN----------QLQQKEV---- 105
L+ E E+ ++ + +EK SE+QI +Q Q+Q+KEV
Sbjct: 838 LKEECEKARQELQEAKEKVAGIESHSELQISRQQNELAELHANLARALQQVQEKEVRAQK 897
Query: 106 ---EISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHD--- 159
++S L+ + A ++ +L++ + AG TAS P+ D
Sbjct: 898 LADDLSTLQEKMAATSKEVARLETLVRK----AGEQQETASRELV----KEPARAGDRQP 949
Query: 160 ---DDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQN 216
++ S+Q + + E ++ +E+ R S+ Q + Q E
Sbjct: 950 EWLEEQQGRQFCSTQAALQAMEREAEQMGNELERLRAALMESQGQQQEERGQQE-----R 1004
Query: 217 IIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGG 276
+ L Q R + D E + + +L R E + +E + L ++ G
Sbjct: 1005 EVARLTQERGRAQADLALEKAARAEL-EMRLQNALNEQRVEFATLQEALAHA--LTEKEG 1061
Query: 277 SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQ 336
+ +L+K+ + ++ QI K++E+L +K + ++L+ E + Q
Sbjct: 1062 K---DQELAKL----RGLEAAQI------KELEELRQTVKQLKEQLAKKEKEHASGSGAQ 1108
Query: 337 EQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERIL-AQSAS------------ 383
+ + E L+ E SKL+ KQ + ER L A+ AS
Sbjct: 1109 SEAAGRTEPTGPKLEALRAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQ 1168
Query: 384 ------VEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRI--EVLEKEKSLLS 435
+E+ Q AL+ A+ E+ + QD+S AED K ++ + E++ SL+S
Sbjct: 1169 GQLEEKAQELGHSQSALASAQRELAAFRTKVQDHSKAEDEWKAQVARGRQEAERKNSLIS 1228
Query: 436 QEKEE---LQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
+EE L +L+ E + +K + +L + L+A+ + +E+ +
Sbjct: 1229 SLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNSARAAERSS 1288
Query: 493 LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMD 552
+ E E+ +EA K + ++ L+Q+L + +R +L
Sbjct: 1289 ALRE--EVQSLREEAEKQRVASEN---------------LRQELTSQAERAEELG----- 1326
Query: 553 ITKELDVQKEKLIQSEVALNDL---HLTKQKLEDKV---ENLVDQLNKSQESNVSIQKEN 606
+EL +EK Q E AL+ L H + Q L ++ ++L QL Q + +E
Sbjct: 1327 --QELKAWQEKFFQKEQALSTLQLEHTSTQALVSELLPAKHLCQQLQAEQAAAEKRHREE 1384
Query: 607 LELKEHIRQN-EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLN 665
LE + EL R + EL + + ++ ++ AE + + LS L++ +
Sbjct: 1385 LEQSKQAAGGLRAELLRAQRELGELIPLRQKVAEQERTAQQLRAEKASYAEQLSMLKKAH 1444
Query: 666 -------------ENLKKVAFDVKMEN--EKLVLACEDVRHQLEECLAGNNQLSLEKNTI 710
NL + +V+++ EK V VR E LA ++ E +
Sbjct: 1445 GLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRLA---EVQREAQST 1501
Query: 711 VETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQK 770
L++ + E AK ++LEE ++++ ++L+ Q+E + + Q
Sbjct: 1502 ARELEVMTAKYEG----AKVKVLEERQRFQEERQKLT---------AQVEQLEVFQREQT 1548
Query: 771 KDMEIAELKKNIEQMDTDHKETKDVLSS-------SLEEQKQLTQLINKKEIFIEKLKER 823
K +E EL K + D K + L + S +E ++L +N+ + + + ++
Sbjct: 1549 KQVE--ELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQLSQKEQA 1606
Query: 824 SSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVA 883
+ + +++K + Q ++E+ RSL +++EN L+ E ERL E + A +
Sbjct: 1607 AEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELRAEAERLGHELQQ-AGLK 1665
Query: 884 DPKTLDSVTELASEVSQLNTIKEHLEEEIK 913
+ + L ++V L H +++++
Sbjct: 1666 TKEAEQTCRHLTAQVRSLEAQVAHADQQLR 1695
Score = 69.3 bits (168), Expect = 3e-11
Identities = 140/725 (19%), Positives = 289/725 (39%), Gaps = 131/725 (18%)
Query: 5 LGGLGSGLGQSLGQVGGSLASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAIL 64
L GL + + L ++ ++ L Q++ K+ + EA RT+ L
Sbjct: 1069 LRGLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAA---GRTEPTGPKLEAL 1125
Query: 65 RSENERLKKLCTDLEEKHEASEIQIKQQSTS----------YRNQLQQKEVEISHLKARQ 114
R+E +L++ C +E+ ++ E ++ + S + QL++K E+ H ++
Sbjct: 1126 RAEVSKLEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL 1185
Query: 115 IALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEI 174
+ Q +L ++F + H A +D + +QE
Sbjct: 1186 ASAQREL----------------------AAFRTKVQDHSKA---EDEWKAQVARGRQEA 1220
Query: 175 NRLSNEVSRLESEV-----------GHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQ 223
R ++ +S LE EV G + + + A+ + E +L
Sbjct: 1221 ERKNSLISSLEEEVSILNRQVLEKEGESKELKRLVMAESEKSQKLEERLRLLQAETASNS 1280
Query: 224 NRSQEIDDHQHE--MSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIE 281
R+ E E S+ + A +Q++ S R+EL+ ER EEL L+
Sbjct: 1281 ARAAERSSALREEVQSLREEAEKQRVA--SENLRQELTSQAERAEELGQELKAWQE---- 1334
Query: 282 TDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNV 341
K ++ ++ + LQ+E + + +L K + ++L + EQ
Sbjct: 1335 ----KFFQKEQALSTLQLEHTSTQALVSELLPA-KHLCQQLQA------------EQAAA 1377
Query: 342 EKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEI 401
EKR EE E K L + +L + E+ L+Q +++ E
Sbjct: 1378 EKRH-REELEQSKQAAGGL-------------RAELLRAQRELGELIPLRQKVAEQERTA 1423
Query: 402 MRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATR 461
+L + + S AE ++ +L+K LL++E L L ++ ++ R
Sbjct: 1424 QQLRA--EKASYAE-------QLSMLKKAHGLLAEENRGLG-ERANLGRQFLEVELDQAR 1473
Query: 462 DISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQ 521
+ + EL +R + E + E+ + E ++ E+E + + + A ++ + + ++
Sbjct: 1474 EKYVQ-ELAAVRADAETRLAEVQR---EAQSTARELEVMTAKYEGAKVKVLEERQRFQEE 1529
Query: 522 QNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKL--IQS------------ 567
+ + + + +L+ ++ K+V +L D + VQ++KL +Q+
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRL 1589
Query: 568 EVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEE--------- 618
+ LN+L + E E+ Q+ K++ + +++N EL+E +R E+
Sbjct: 1590 QAQLNELQAQLSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLRSLEQLQKENKELR 1649
Query: 619 -ELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKK--VAFDV 675
E R+ +EL Q+ + + + A+VR+L+ ++ +Q +L K VA D
Sbjct: 1650 AEAERLGHELQQA---GLKTKEAEQTCRHLTAQVRSLEAQVAHADQQLRDLGKFQVATDA 1706
Query: 676 KMENE 680
E
Sbjct: 1707 LKSRE 1711
>gi|109255234 centrosomal protein 290kDa [Homo sapiens]
Length = 2479
Score = 185 bits (469), Expect = 4e-46
Identities = 311/1536 (20%), Positives = 668/1536 (43%), Gaps = 193/1536 (12%)
Query: 356 ECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAE 415
E K+ P + + + + + I V E+ S+ + ++ L + Q + +
Sbjct: 9 EIMKVDPDDLPRQEELADNLLISLSKVEVNEL------KSEKQENVIHLFRITQ-SLMKM 61
Query: 416 DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTAT-RDIS-LDSELHDLR 473
++++ +E +EK ++ + +L+ ++KL NE E+ + +A RD L +E+ L
Sbjct: 62 KAQEVELALEEVEKAGEEQAKFENQLKTKVMKLENELEMAQQSAGGRDTRFLRNEICQLE 121
Query: 474 LNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK 533
LE K++EL E+++++ ++ K + +QL+ + E ++ SKL+
Sbjct: 122 KQLEQKDREL--------------EDMEKELEKEKK----VNEQLALRNEEAENENSKLR 163
Query: 534 QDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLN 593
++ KK+ QL D +D K++D QKE L+ +D K ++ +D++
Sbjct: 164 RENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKNYELIQYLDEIQ 223
Query: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNEL--MQSLNQDSNSNFKDTLLKEREAEV 651
E+N I+ +N E+++++ ++ +E+ ++ +E M+++ ++ N D L KE +
Sbjct: 224 TLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTD-NVIDQLKKENDHYQ 282
Query: 652 RNLKQNLSELEQLNE--NLKKVAFDVKMENEKLVLACED--------VRHQLEECLAGNN 701
+++ L+ NE + VA + K+E KL+L+ +D + H L E L N
Sbjct: 283 LQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLK-NA 341
Query: 702 QLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEK-------TIEELSNARNLNT 754
QL +K+ ++ L+ E ++++ K L E+ +Y K IE+L N N
Sbjct: 342 QLDADKSNVM-ALQQGIQERDSQI----KMLTEQVEQYTKEMEKNTCIIEDLKNELQRNK 396
Query: 755 SALQLEHEHLIKLNQKKDM---EIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLIN 811
A L + +K+ D+ + E ++ E + D +E L +L+ K +
Sbjct: 397 GASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVY 456
Query: 812 KKEIFIEKLKERSSKLQ---EELD-----------KYSQALRKNEILRQTIEEKDRSLGS 857
E + ++K ++++ E++ K S L +NE LR+ + + +++
Sbjct: 457 GLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMID 516
Query: 858 MKEENN--HLQEELER------LREEQSRTAPVADPKTLDSVTELASE------VSQLNT 903
+ E N HL+++ R L+E +S D K + ++A E S L T
Sbjct: 517 LTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLK--KKIRQMAQERGKRSATSGLTT 574
Query: 904 IKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE 963
+L E I +I ++ K+ LL K M E + ++E + ++ +EK+
Sbjct: 575 EDLNLTENISQGDRI----SERKLDLL-----SLKNMSEAQSKNEFL----SRELIEKER 621
Query: 964 EIKSLQKTIEQIKTQLH---EERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETER 1020
+++ + I + + +L EE + ++ +I Q K + + + L ER
Sbjct: 622 DLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPSLER 681
Query: 1021 LVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSH 1080
LV I+ + E + + ++ L Q+DQL+ + ++L + +R + ++
Sbjct: 682 LVNAIESKNAE--GIFDASLHLKAQVDQLTG----------RNEELRQELRESRKEAINY 729
Query: 1081 TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDEN 1140
+Q + ++ EK ++L + E S++ + + D +A A++I Q+E
Sbjct: 730 SQQLAKANLKID----HLEKETSLLRQS--EGSNVVFKGIDLPDGIAPSSASIINSQNEY 783
Query: 1141 K-KLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGV 1199
L E+ + ++NL + + + + A+ + Q+LL S E
Sbjct: 784 LIHLLQELENK-----EKKLKNLEDSLEDYNRKF-AVIRHQQSLLYKEYLSE--KETWKT 835
Query: 1200 NSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDN 1259
S +E E+ KL+ QV++ ++ + +Q +S ++++ L + ++ V N
Sbjct: 836 ESKTIKE---EKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVN 892
Query: 1260 NSKLQVDYTGLI----QSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQ 1315
L YT L+ Q ++NE + A+V IG L K++ + K+ +
Sbjct: 893 EKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKV 952
Query: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQE--LEELRKSLQEKDATIRTLQENNHRL 1373
+ ++ L+ E +E+ ++ ++LQ++ L + +L+ + +L+E +
Sbjct: 953 VDNSVSLS--ELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESI 1010
Query: 1374 SDSIAATSELERKEHEQTDSEIKQLKE-KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTN 1432
+ + T E + + E K E D +K + D++ +K +L E
Sbjct: 1011 NKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNER 1070
Query: 1433 KVNEN-----ELLRQAVTNLKERILILE---MDIGKLKGENEKIVETYRGK--ETEYQAL 1482
+ E+ E LR ++ ++ER LE ++ K+ + +K+ + R + ++ +A+
Sbjct: 1071 QRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAV 1130
Query: 1483 QETNMKFSMMLREKEFE-------CHSMKEKALAFEQLLKEKEQGKTGELN----QLLNA 1531
+ + + + L + E E + + A ++L ++Q + E+ QLL+
Sbjct: 1131 SDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDY 1190
Query: 1532 VKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLES 1591
EK+++ + + V L L E TAL +++ + K + RL L E
Sbjct: 1191 QAQSDEKSLIAKLHQHNVSLQLS----EATAL-GKLESITSKLQKMEAYNLRLEQKLDEK 1245
Query: 1592 EDSYTREALAAEDREAKLRKKVTVL------------EEKLVSSSNAMENASHQASVQVE 1639
E + L +R LR+ + L +EK + ++N + +++
Sbjct: 1246 EQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMK 1305
Query: 1640 SLQEQLNVVSKQRDETALQLSVSQEQVK-----QYALSLANLQMVLEHFQQEEKAMYSAE 1694
+ Q++ + + E L+L +E + + A + N M +E + +E + + E
Sbjct: 1306 NSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKL-NRE 1364
Query: 1695 LEKQKQ-------LIAEWKKNAENLEGKVISLQECLDEANAALDSAS-RLTEQLDVKEEQ 1746
L K K+ +I+E+++ +LE +++ + +E A D L QLD+ + Q
Sbjct: 1365 LVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQ 1424
Query: 1747 IEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
E+ + +E + + L N E + K+
Sbjct: 1425 QNEILNAAQKFEEATGSIPDPSLPLPNQLEIALRKI 1460
Score = 178 bits (451), Expect = 5e-44
Identities = 392/1893 (20%), Positives = 782/1893 (41%), Gaps = 273/1893 (14%)
Query: 53 RTKEIEAIHAILRSENERLKK----LCTDLEEKHEASEIQ------IKQQSTSYRNQLQQ 102
R +E E ++ LR EN+RLKK LC D+ + + + Q + + + YR+QL +
Sbjct: 151 RNEEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSK 210
Query: 103 KEVEISHLKARQIALQDQLLKLQSAAQSV-----PSGAGVPATTASSSFAYGISHHPSAF 157
K E+ L + K++ Q + S + T + I H
Sbjct: 211 KNYELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNV 270
Query: 158 HDDDMDFGDIISSQ-QEINRL---SNE-----VSRLESEVGHWRHIAQTSKAQGTDNSDQ 208
D D Q QE+ L NE + + ++V W+ I +S
Sbjct: 271 IDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLIL---------SSKD 321
Query: 209 SEICKLQNIIKELKQN-RSQEIDDHQHEMSVLQNAHQQK------LTEISRRHREELSDY 261
EI + Q ++ L++ ++ ++D + + LQ Q++ LTE ++ +E+
Sbjct: 322 DEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKN 381
Query: 262 EERIEELENLLQ--QGGSGVIETDLSKIY-----------EMQKTIQVLQIEKVESTKKM 308
IE+L+N LQ +G S + + KI E ++T ++ + + E K++
Sbjct: 382 TCIIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAERTAELAEADAREKDKEL 441
Query: 309 EQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQS 368
+ ++KD + E+ ++ + Q+ + R+I E L E +KL+ +K S
Sbjct: 442 VEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREI----EILTKEINKLE---LKIS 494
Query: 369 DTMTE----KERILAQSASVEEV--FR----LQQALSDAENEIMRLSSLNQDNSLAEDNL 418
D + E +ER+ + ++ ++ FR L+Q AEN+I+ L + SL E+ L
Sbjct: 495 DFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQIL----LKEIESLEEERL 550
Query: 419 KLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEA 478
LK +I + +E+ S L T +IS + + +L+L
Sbjct: 551 DLKKKIRQMAQERGKRSATSGLTTEDL------------NLTENISQGDRISERKLDL-L 597
Query: 479 KEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLND 538
+ ++++ S+ E L E+ E +R + + + +++L + E + +K+ L
Sbjct: 598 SLKNMSEAQSKNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEIL-Q 656
Query: 539 EKKRVHQLEDDKMDITKELDVQKEKLIQSEVALN-------DLHLTKQ--KLEDKVENLV 589
K + + D K T + E+L+ + + N LHL Q +L + E L
Sbjct: 657 AIKEMQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELR 716
Query: 590 DQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKE--- 646
+L +S++ ++ ++ + I E+E S +R ++ SN FK L +
Sbjct: 717 QELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQ------SEGSNVVFKGIDLPDGIA 770
Query: 647 -REAEVRNLKQN-----LSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGN 700
A + N + L ELE + LK + ++ N K + +RHQ + L
Sbjct: 771 PSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAV----IRHQ--QSLLYK 824
Query: 701 NQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLE 760
LS EK ET K E I+ E K++L ++ + ++E +N N ALQ++
Sbjct: 825 EYLS-EK----ETWKTESKTIKEE----KRKLEDQVQQDAIKVKEYNNLLN----ALQMD 871
Query: 761 HEHLIKLNQKKDMEIAELKKN----IEQMDT-----------DHKETKDVLSSSLEEQKQ 805
+ + K+ + +I L+ N I Q T + K+ ++LS E ++
Sbjct: 872 SDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEK 931
Query: 806 LTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHL 865
+ L KE+ I K+ + LQ+ +D S +L + E+ + E + +++N L
Sbjct: 932 IGCLQRFKEMAIFKI----AALQKVVDN-SVSLSELELANKQYNELTAKYRDILQKDNML 986
Query: 866 QEELERLREEQSRTAPVADPKTLDSVT-ELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
+ L E ++ + ++S+ EL +L+TI++ E+E K + D+ +
Sbjct: 987 VQRTSNL--EHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAK 1044
Query: 925 SKMQLLQSLQEQKK-EMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEER 983
+ + KK M E + +E+ A H Q + E +++ K +E+ +L +
Sbjct: 1045 KSITNSDIVSISKKITMLEMKELNERQRAEHCQ---KMYEHLRTSLKQMEERNFELETKF 1101
Query: 984 QDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLT 1043
++ N D + ++ + + K +S A+ +R+++ +++ E+E+K+ +S
Sbjct: 1102 AELTKINLDAQKVEQMLRDELADSVSK-AVSDADRQRILE-LEKNEMELKV----EVSKL 1155
Query: 1044 KQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQD----VVYLQQQLQAYAMERE 1099
++I +++ +V L Q +D E+++L ++ D + L Q + +
Sbjct: 1156 REISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEA 1215
Query: 1100 KVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETI 1159
L T + ++ ++ + KE AL + E + + + Q + R+
Sbjct: 1216 TALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFS 1275
Query: 1160 QNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVK 1219
L +EK + + Q L ++Q + N+ E+ + L++ +
Sbjct: 1276 GALPLAQQEKFSK--TMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIS 1333
Query: 1220 KMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQ---VDYTGLIQSYEQ 1276
+++ K +M+ E +LQE +L +++ D + L +Y I S E+
Sbjct: 1334 TLKDTKGAQKVINWHMKIEELRLQE--LKLNRELVKDKEEIKYLNNIISEYERTISSLEE 1391
Query: 1277 NETKLKNFGQE--LAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRA-- 1332
+ F +E +A Q + L +LDI Q + + E +
Sbjct: 1392 EIVQQNKFHEERQMAWDQREVD--------LERQLDIFDRQQNEILNAAQKFEEATGSIP 1443
Query: 1333 SKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTD 1392
S L E+ ++++E + + E AT ++L+E +L + +A L + D
Sbjct: 1444 DPSLPLPNQLEIALRKIKENIRIILETRATCKSLEE---KLKEKESAL-RLAEQNILSRD 1499
Query: 1393 SEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR-QAVTNLKERI 1451
I +L+ + E++ LI + + + T K+ + QA N KE +
Sbjct: 1500 KVINELRLRLPA----TAEREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEEV 1555
Query: 1452 LILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFE 1511
L + ++++E R ++ E E ++ E + + K K A++
Sbjct: 1556 L----------KKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWD 1605
Query: 1512 QLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLR 1571
+ K+ N+ + M E+TV Q + +L +K ++ Q E+ L+
Sbjct: 1606 LM---KQSPTPVPTNKHFIRLAEM-EQTVAEQDDSLSSLLVKLKKVSQDLERQREITELK 1661
Query: 1572 DKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENAS 1631
KEF N +L+ NH ED K++ +V L+ L S +
Sbjct: 1662 VKEF-ENIKLQLQENH---------------EDEVKKVKAEVEDLKYLLDQSQKESQCLK 1705
Query: 1632 HQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMY 1691
+ Q E+ + E L+ ++ ++ +Q ALS A L++ E E+ +
Sbjct: 1706 SELQAQKEANSRAPTTTMRNLVE-RLKSQLALKEKQQKALSRALLELRAEMTAAAEERII 1764
Query: 1692 SAELEKQKQL---------IAEWKKNAENLEGKVISLQECL----DEANAALDSASRLTE 1738
SA +K+ L E K E+L ++ L+E L + N+ D+ + L
Sbjct: 1765 SATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNN 1824
Query: 1739 QLDVK--------------EEQIEELKRQ-------------NELRQEMLDDVQKKLMSL 1771
+L K +++ +ELKRQ + +Q +++++Q+K+ L
Sbjct: 1825 ELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKL 1884
Query: 1772 ANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLR 1804
N EGKV++V ++ + KN + E++R
Sbjct: 1885 ENQLEGKVEEVDLKPM------KEKNAKEELIR 1911
Score = 177 bits (449), Expect = 9e-44
Identities = 353/1739 (20%), Positives = 723/1739 (41%), Gaps = 279/1739 (16%)
Query: 213 KLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLL 272
+L+N K+LK N ++D+ + +V++ HQQ L ++E LS+ E E + +
Sbjct: 790 ELENKEKKLK-NLEDSLEDYNRKFAVIR--HQQSLL-----YKEYLSEKETWKTESKTIK 841
Query: 273 QQGGS--GVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRD 330
++ ++ D K+ E + LQ++ E K + + KI + N++
Sbjct: 842 EEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQV------NEKS 895
Query: 331 ILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTE-KERILAQSASVEEVFR 389
++R+ + +E RQ+ +E E K E ++ ++ + KE + + A++++V
Sbjct: 896 LIRQYTTLVELE-RQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVD 954
Query: 390 LQQALSDAE------NEIMRL--SSLNQDNSLAE----------DNLKLKMRIEVLEKEK 431
+LS+ E NE+ L +DN L + +N+ LK ++E + KE
Sbjct: 955 NSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKEL 1014
Query: 432 SLLSQEKEELQMSL---LKLNNEYEVIKS----TATRDISLDSELHDLRLNLEAKEQELN 484
+ ++ ++ + KL NE + K+ T + +S+ ++ L + + Q
Sbjct: 1015 EITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAE 1074
Query: 485 QSISEKETLIAEIEELDRQNQEA-TKHMILIKDQLSKQQNEG---DSIISKLKQDLND-E 539
E L +++++ +N E TK L K L Q+ E D + + + ++D +
Sbjct: 1075 HCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDAD 1134
Query: 540 KKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL------- 592
++R+ +LE ++M++ E+ +E + + L+ +Q + +VE+L QL
Sbjct: 1135 RQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQS 1194
Query: 593 ------NKSQESNVSIQKEN---LELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTL 643
K + NVS+Q L E I +++ L Q L++ + + L
Sbjct: 1195 DEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARL 1254
Query: 644 LKEREAE-----VRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLA 698
A+ +++L++ S L + K ++++N+KL + E Q E
Sbjct: 1255 EGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNM 1314
Query: 699 GNNQLSLEKNT-----IVETLKMEKGEIEA--------ELCWAKKRLLEEANKYEKTIEE 745
N L +E ++ TLK KG + EL + +L E K ++ I+
Sbjct: 1315 ENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKY 1374
Query: 746 LSNARNLNTSALQLEHEHLI---KLNQKKDMEIAELKKNIE-QMDTDHKETKDVLSSSLE 801
L+N + + E ++ K ++++ M + + ++E Q+D ++ ++L+++ +
Sbjct: 1375 LNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQK 1434
Query: 802 EQKQLTQ-------LINKKEIFIEKLKER----------SSKLQEELDKYSQALRKNEIL 844
++ L N+ EI + K+KE L+E+L + ALR E
Sbjct: 1435 FEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAE-- 1492
Query: 845 RQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTI 904
Q I +D+ + ++ E E+L E R +PK+ ++ ++ +
Sbjct: 1493 -QNILSRDKVINELRLRLPATAER-EKLIAELGRKE--MEPKSHHTLKIAHQTIANMQAR 1548
Query: 905 KEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEE 964
EE +K +Q+++E + + ++++ E ++ H +L L+ D
Sbjct: 1549 LNQKEEVLKKYQRLLEKAREEQREIVKK-------------HEEDLHILHHRLELQADSS 1595
Query: 965 IKSLQKT----IEQIKTQLHEERQDI---QTDNSDIFQETKVQSLNIENGSEKHDLSKAE 1017
+ ++T ++Q T + + I + + + Q+ + SL ++ DL E
Sbjct: 1596 LNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDL---E 1652
Query: 1018 TERLVKGIKERELE-IKL-LNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARI 1075
+R + +K +E E IKL L E + K++ K EV L ++ Q E Q L +
Sbjct: 1653 RQREITELKVKEFENIKLQLQENHEDEVKKV----KAEVEDLKYLLDQSQKESQCLKSE- 1707
Query: 1076 SSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
LQ Q +A + L E+ + LK + K + + A +
Sbjct: 1708 -----------LQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMT 1756
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE 1195
E + +S +S ++ Q + R RE +++ L++ L L+TS
Sbjct: 1757 AAAEERIISA---TSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNREN 1813
Query: 1196 AGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLV 1255
+ N N LQ++ K ++ + +E + E+ +L+ ++ +L + +
Sbjct: 1814 SLTDNLNDLNNELQKKQKAYNKILREKE----------EIDQENDELKRQIKRLTSGL-- 1861
Query: 1256 DSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQ 1315
L + LI+ ++ KL+N L GK++ +
Sbjct: 1862 ---QGKPLTDNKQSLIEELQRKVKKLEN--------------------QLEGKVEEVD-- 1896
Query: 1316 LSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSD 1375
L P + A + + E + Q ++E +R L+EK+ + TL + + L D
Sbjct: 1897 ------LKPMKEK--NAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKD 1948
Query: 1376 SIAATSE----LERKEHEQTDSEIKQL---------KEKQDVLQKLLKEKDLLIKAKSDQ 1422
A + L+RK + T + Q+ KE +++ ++ L ++ ++ ++ Q
Sbjct: 1949 LFAKADKEKLTLQRKL-KTTGMTVDQVLGIRALESEKELEELKKRNLDLENDILYMRAHQ 2007
Query: 1423 LLSSNENFTNKVNENELLRQAVTNLKERI---LILEMDIGKLKGENEKIVETYRGKETEY 1479
L + + +N L++ + L+++ + I ++ ++ E KE
Sbjct: 2008 ALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLK 2067
Query: 1480 QALQETNMKFSM------------MLREKEFECHSMK-EKALAFEQLLKEKEQGKTG--- 1523
+ + +KF + +R+ + C +K EKA +L + G++G
Sbjct: 2068 LSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTI 2127
Query: 1524 -ELNQLLNAVKSMQEKTVVFQQERDQVMLA---LKQKQMENTALQNEVQRLRDKEFRSNQ 1579
EL + + +K + EK Q+E +Q+ A L ++M N +NE +
Sbjct: 2128 PELEKTIGLMKKVVEKV---QRENEQLKKASGILTSEKMANIEQENE---------KLKA 2175
Query: 1580 ELERLRNHL-------LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASH 1632
ELE+L+ HL ES+ T + +A +R K KK T EKL + N +E +
Sbjct: 2176 ELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNE 2235
Query: 1633 QASVQVESLQEQLNVVSKQRDETALQLSVSQEQV---KQYALSLANL------------- 1676
+ +VQ+E ++L + + S S + + + Y L L
Sbjct: 2236 KMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITD 2295
Query: 1677 --QMVLEHFQQEEKA-MYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALD-S 1732
Q+V E ++E+K Y+ +LE+Q +++ + AE +G LQ L AN LD
Sbjct: 2296 LKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQ-VLRLANHQLDKE 2354
Query: 1733 ASRLTEQLDVKEEQI---EELKRQNELRQEMLD-DVQKKLMSLANSSEGKVDKVLMRNL 1787
+ L Q++ ++Q + ++L++++ D + Q K+ L + K L + L
Sbjct: 2355 KAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKEL 2413
Score = 169 bits (429), Expect = 2e-41
Identities = 364/1783 (20%), Positives = 736/1783 (41%), Gaps = 262/1783 (14%)
Query: 208 QSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE- 266
Q + L I + L + ++QE++ E+ +K E + +L ++E
Sbjct: 45 QENVIHLFRITQSLMKMKAQEVELALEEV--------EKAGEEQAKFENQLKTKVMKLEN 96
Query: 267 ELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLS--- 323
ELE Q G ++I +++K ++ +K + ME+ +K K +N++L+
Sbjct: 97 ELEMAQQSAGGRDTRFLRNEICQLEKQLE----QKDRELEDMEKELEKEKKVNEQLALRN 152
Query: 324 -SAENDRDILRREQEQLNVEKRQIME---------------------ECENLKLECSKLQ 361
AEN+ LRRE ++L + Q+ + E + + + SK
Sbjct: 153 EEAENENSKLRRENKRLKKKNEQLCQDIIDYQKQIDSQKETLLSRRGEDSDYRSQLSKKN 212
Query: 362 PSAVKQSD---TMTE-KERILAQS----ASVEEVFRLQQALSDAENEIMRL--SSLNQDN 411
++ D T+TE E+I Q+ ++EE + + ++D N + + + N +
Sbjct: 213 YELIQYLDEIQTLTEANEKIEVQNQEMRKNLEESVQEMEKMTDEYNRMKAIVHQTDNVID 272
Query: 412 SLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYE----VIKSTATRDISLDS 467
L ++N +++++ L LL + EE ++ +N + E ++ S I
Sbjct: 273 QLKKENDHYQLQVQEL---TDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQ 329
Query: 468 ELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDS 527
LH+LR L K +L+ S L I+E D Q + T+ + +Q +K+ +
Sbjct: 330 MLHNLREKL--KNAQLDADKSNVMALQQGIQERDSQIKMLTEQV----EQYTKEMEKNTC 383
Query: 528 IISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVEN 587
II LK +L K + M I LD+ KEK ++E L + +K +
Sbjct: 384 IIEDLKNELQRNKGASTLSQQTHMKIQSTLDILKEKTKEAE---RTAELAEADAREKDKE 440
Query: 588 LVDQLN--KSQESNV-----------------------------SIQKENLELKEHIRQN 616
LV+ L K ES V I K L++ + + +N
Sbjct: 441 LVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDEN 500
Query: 617 EEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVK 676
E R+ E ++ N K ++ AE + L + + LE+ +LKK +
Sbjct: 501 EALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMA 560
Query: 677 MENEKLV----LACEDVRHQLEECLAGNNQLSLEKNTIVETLKM----EKGEIEAELCWA 728
E K L ED+ L E ++ +++S K ++ M K E +
Sbjct: 561 QERGKRSATSGLTTEDL--NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIE 618
Query: 729 KKRLLEEAN----KYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ 784
K+R LE + K++ ++EL ++ + + ++ + D++ E I
Sbjct: 619 KERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKEMQKDPDVKGGETSLIIPS 678
Query: 785 MD-----TDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALR 839
++ + K + + +SL + Q+ QL + E ++L+E ++E YSQ L
Sbjct: 679 LERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRES----RKEAINYSQQLA 734
Query: 840 KNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKT---LDSVTELAS 896
K + + EK+ SL E +N + + ++ +A + + + + + EL +
Sbjct: 735 KANLKIDHL-EKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELEN 793
Query: 897 EVSQLNTIKEHLEE------EIKHHQKIIEDQNQSKMQL----LQSLQEQKKEMDEFRYQ 946
+ +L +++ LE+ I+H Q ++ + S+ + ++++E+K+++++ Q
Sbjct: 794 KEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQ 853
Query: 947 H----EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSL 1002
++ N L ++ DE K L + +I E+ I+ + + E + L
Sbjct: 854 DAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELE---RQL 910
Query: 1003 NIENGSEKHDLSKAETERLVK-GIKERELEIKLLNEKNISLTKQID--------QLSKDE 1053
EN +K++L E E K G +R E+ + K +L K +D +L+ +
Sbjct: 911 RKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIF--KIAALQKVVDNSVSLSELELANKQ 968
Query: 1054 VGKLT----QIIQQKDLEIQAL----HARISSTSHTQDVVYLQQQLQAYAMEREKVFAVL 1105
+LT I+Q+ ++ +Q H + S + V + ++L+ + +
Sbjct: 969 YNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAW 1028
Query: 1106 NEKTRENSHLKTEYHKM----MDIVA-AKEAALIKLQDEN--------KKLSTRFESSGQ 1152
++T+ + + K DIV+ +K+ ++++++ N +K+ +S +
Sbjct: 1029 EQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLK 1088
Query: 1153 DMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERD 1212
M + ++ I +DA QK + +L S + + EL +
Sbjct: 1089 QMEERNFELETKFAELTKINLDA--QKVEQMLRDELADSVSKAVSDADRQRILELEKNEM 1146
Query: 1213 KLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQ 1272
+LK +V K+ E V+ + + +E+ L+ Q+L + + Q D LI
Sbjct: 1147 ELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLL-----DYQAQSDEKSLIA 1201
Query: 1273 SYEQNETKLK-NFGQELAQVQHSIGQLCNTKDL---LLGKLDIISPQLSSASLLTPQSAE 1328
Q+ L+ + L +++ +L + L KLD L A L A+
Sbjct: 1202 KLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAK 1261
Query: 1329 CLRASKSEVLSESSEL--LQQELEELRKSLQEKDATIRTLQE-----NNHRLSDSIAATS 1381
LR + + + S L Q+ + + +Q ++ ++ +QE HR ++
Sbjct: 1262 HLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEM 1321
Query: 1382 ELERKEHEQTDSEIKQLKEKQDVL-----------------QKLLKEKDLL-----IKAK 1419
EL+ K E+ S +K K Q V+ ++L+K+K+ + I ++
Sbjct: 1322 ELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISE 1381
Query: 1420 SDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEY 1479
++ +SS E + N+ RQ + +E L ++DI + +NE + + +E
Sbjct: 1382 YERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFD-RQQNEILNAAQKFEEATG 1440
Query: 1480 Q--------------ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGEL 1525
AL++ ++L E C S++EK E L+ EQ
Sbjct: 1441 SIPDPSLPLPNQLEIALRKIKENIRIIL-ETRATCKSLEEKLKEKESALRLAEQNILSR- 1498
Query: 1526 NQLLNAVKSMQEKTVVFQQERDQVMLALKQKQME---NTALQNEVQRLRDKEFRSNQELE 1582
++++N ++ T ER++++ L +K+ME + L+ Q + + + R NQ+ E
Sbjct: 1499 DKVINELRLRLPATA----EREKLIAELGRKEMEPKSHHTLKIAHQTIANMQARLNQKEE 1554
Query: 1583 RLRNH--LLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVES 1640
L+ + LLE RE + + + + LE + SS N + + Q +
Sbjct: 1555 VLKKYQRLLEKAREEQREIVKKHEEDLHILHH--RLELQADSSLNKFKQTAWDLMKQSPT 1612
Query: 1641 ----------LQEQLNVVSKQRDETALQL----SVSQEQVKQYALS------LANLQMVL 1680
L E V++Q D + L VSQ+ +Q ++ N+++ L
Sbjct: 1613 PVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQL 1672
Query: 1681 EHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEA--NAALDSASRLTE 1738
+ ++E AE+E K L+ + +K ++ L+ ++ + +E A + RL
Sbjct: 1673 QENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKS 1732
Query: 1739 QLDVKEEQIEELKRQ-NELRQEMLDDVQKKLMSLANSSEGKVD 1780
QL +KE+Q + L R ELR EM +++++S + E ++
Sbjct: 1733 QLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLN 1775
Score = 144 bits (362), Expect = 1e-33
Identities = 343/1784 (19%), Positives = 710/1784 (39%), Gaps = 296/1784 (16%)
Query: 19 VGGSLASLTGQISNFTKDML--MEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCT 76
+ S AS+ + + +L +E E+ L DS ++ A++R + L K
Sbjct: 769 IAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDS-LEDYNRKFAVIRHQQSLLYKEYL 827
Query: 77 DLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQ---DQLLKLQSAAQSVPS 133
+E + IK++ +Q+QQ +++ ALQ D++ K+ + +
Sbjct: 828 SEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKIT 887
Query: 134 GAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEI------------------- 174
V + + + +++ +++S + E+
Sbjct: 888 VLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIA 947
Query: 175 ---NRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNI---------IKELK 222
+ N VS E E+ + ++ T+K + D + + N+ +KE
Sbjct: 948 ALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQV 1007
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQK--------------------LTEISRR--------- 253
++ ++E++ + ++ ++ A +Q+ + IS++
Sbjct: 1008 ESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSDIVSISKKITMLEMKEL 1067
Query: 254 -HREELSDYEERIEELENLLQQGGSGVIE-----TDLSKI-YEMQKTIQVLQIEKVESTK 306
R+ ++ E L L+Q E +L+KI + QK Q+L+ E +S
Sbjct: 1068 NERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVS 1127
Query: 307 K---------MEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLEC 357
K + +LE ++ ++S DI RR+ E LN +++ +E E+L+++
Sbjct: 1128 KAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQL 1187
Query: 358 SKLQPSA-----------------VKQSDTMTEKERILAQSASVEEV-FRLQQALSDAEN 399
Q + + ++ + + E I ++ +E RL+Q L + E
Sbjct: 1188 LDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQ 1247
Query: 400 EI--MRLSSLNQDNSLAE------------------------------DNLKLKMRIEVL 427
+ RL N+ L + D LK+ ++
Sbjct: 1248 ALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNS 1307
Query: 428 EKEKSLLSQEKEELQMSLLKLNNEYEVIKST--ATRDISL-----DSELHDLRLNLE-AK 479
++E + + E+++ L L +K T A + I+ + L +L+LN E K
Sbjct: 1308 QQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELRLQELKLNRELVK 1367
Query: 480 EQE----LNQSISEKETLIAEIEELDRQNQEATKHMILIKDQ----LSKQQNEGDSIISK 531
++E LN ISE E I+ +EE Q + + + DQ L +Q + D ++
Sbjct: 1368 DKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNE 1427
Query: 532 LKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQ 591
+ ++ + D + + +L++ K+ ++ + + T + LE+K++
Sbjct: 1428 ILNAAQKFEEATGSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESA 1487
Query: 592 LNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEV 651
L ++++ +S K EL+ + E R +L+ L + LK +
Sbjct: 1488 LRLAEQNILSRDKVINELRLRLPATAE-----REKLIAELGRKEMEPKSHHTLKIAHQTI 1542
Query: 652 RNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACED----VRHQLEECLAGNNQLSLEK 707
N++ L++ E++ + +++ + E ++V E+ + H+LE L ++ L+ K
Sbjct: 1543 ANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLE--LQADSSLNKFK 1600
Query: 708 NTIVETLK------------MEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTS 755
T + +K + E+E + L K +K ++L R +
Sbjct: 1601 QTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITEL 1660
Query: 756 ALQLEHEHLIKLNQKKDMEIAELKKNIEQ----MDTDHKETKDVLSSSLEEQKQLTQLIN 811
++ ++L + + E+ ++K +E +D KE++ L S L+ QK+
Sbjct: 1661 KVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQ-CLKSELQAQKEANSRAP 1719
Query: 812 KKEI--FIEKLKERSSKLQEELDKYSQALRK-NEILRQTIEEKDRSLGSMKEENNHLQEE 868
+ +E+LK + + +++ S+AL + + EE+ S S KE + ++Q+
Sbjct: 1720 TTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQI 1779
Query: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQ 928
++R E + L L + ++ N++ ++L + QK + ++ +
Sbjct: 1780 VDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQK----KQKAYNK 1835
Query: 929 LLQSLQEQKKEMDEFRYQHEQMNA--THTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDI 986
+L+ +E +E DE + Q +++ + L K I+ LQ+ +++++ QL + +++
Sbjct: 1836 ILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV 1895
Query: 987 QTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQI 1046
+ K + + E G + +A+ E + +KE+E E+ +LTKQ+
Sbjct: 1896 DLKPMK-EKNAKEELIRWEEGKK----WQAKIEGIRNKLKEKEGEV-------FTLTKQL 1943
Query: 1047 DQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLN 1106
+ L + + D E L ++ +T T D Q L A+E EK L
Sbjct: 1944 NTLK--------DLFAKADKEKLTLQRKLKTTGMTVD-----QVLGIRALESEKELEELK 1990
Query: 1107 EKT--RENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSR 1164
++ EN L H+ + +++ + L +N+ L + + + ++T S
Sbjct: 1991 KRNLDLENDILYMRAHQAL----PRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPS- 2045
Query: 1165 IIREKDIEIDALSQKCQTLLAV-LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEE 1223
IE D Q+ Q L L+ SS E Q E+ ++ +LK QV+ ++E
Sbjct: 2046 ---ISGIESDDHCQREQELQKENLKLSSENIEL----KFQLEQANKDLPRLKNQVRDLKE 2098
Query: 1224 W----KQQVMTTVQNMQH-----ESAQLQEELHQ---LQAQVLVDSDNNSKLQVDYTGLI 1271
K++ + + H S + EL + L +V+ ++ +G++
Sbjct: 2099 MCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGIL 2158
Query: 1272 QS-----YEQNETKLKNFGQEL-AQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQ 1325
S EQ KLK ++L A + H + +K K+ + +L
Sbjct: 2159 TSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETD 2218
Query: 1326 SAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELER 1385
+AE LR +K+ L +E + +LEE K LQ ++ L+ + + SI T E
Sbjct: 2219 AAEKLRIAKNN-LEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYET 2277
Query: 1386 KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVT 1445
K E +++I + + L++L+KE + E NK NE+
Sbjct: 2278 KLKE-LETDIAKKNQSITDLKQLVKE------------ATEREQKVNKYNED-------- 2316
Query: 1446 NLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKE 1505
LE I LK E ET +G + E Q L+ N + KE
Sbjct: 2317 --------LEQQIKILKHVPEG-AETEQGLKRELQVLRLANHQLD-------------KE 2354
Query: 1506 KALAFEQLLKEKEQ----GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALK--QKQME 1559
KA Q+ K+Q + +QL +K ++ + + E+ + +K +K++E
Sbjct: 2355 KAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELE 2414
Query: 1560 NTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
N + + + D ++ +E++ +N LLE + E L E
Sbjct: 2415 NFD-PSFFEEIEDLKYNYKEEVK--KNILLEEKVKKLSEQLGVE 2455
Score = 141 bits (356), Expect = 6e-33
Identities = 285/1447 (19%), Positives = 601/1447 (41%), Gaps = 185/1447 (12%)
Query: 56 EIEAIHAILRSE-NERLKKLCTDLEEKH----EASEIQIKQQSTSYR--NQLQQKEVEIS 108
+ + + +LR E + + K +D + + E +E+++K + + R + + +++VEI
Sbjct: 1110 DAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEIL 1169
Query: 109 HLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDII 168
+ + + + + L++Q S S A H+ S + G +
Sbjct: 1170 NAQQQSRDKEVESLRMQLLDYQAQSDE-------KSLIAKLHQHNVSLQLSEATALGKLE 1222
Query: 169 SSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQE 228
S ++ ++ RLE ++ ++ +G + + L+ I+ L++ S
Sbjct: 1223 SITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKH-----LRQTIQSLRRQFSGA 1277
Query: 229 IDDHQHE-----MSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET- 282
+ Q E M LQN + K+ + + ++E + E + E+E L +G +I T
Sbjct: 1278 LPLAQQEKFSKTMIQLQN-DKLKIMQEMKNSQQEHRNMENKTLEME-LKLKGLEELISTL 1335
Query: 283 ----DLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQ 338
K+ I+ L++++++ +++ + +++IK +N +S E L E Q
Sbjct: 1336 KDTKGAQKVINWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQ 1395
Query: 339 LNV--EKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVF-----RLQ 391
N E+RQ+ + + LE +L +Q++ + ++ + S+ + +L+
Sbjct: 1396 QNKFHEERQMAWDQREVDLE-RQLDIFDRQQNEILNAAQKFEEATGSIPDPSLPLPNQLE 1454
Query: 392 QALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEK--EELQMSLLKLN 449
AL + I + E+ LK K L E+++LS++K EL++ L
Sbjct: 1455 IALRKIKENIRIILETRATCKSLEEKLKEKESALRLA-EQNILSRDKVINELRLRLPATA 1513
Query: 450 NEYEVIKSTATRDISLDSELHDLRL------NLEAKEQELNQSISEKETLIAEIEELDRQ 503
++I +++ S H L++ N++A+ + + + + + L+ + E Q
Sbjct: 1514 EREKLIAELGRKEMEPKSH-HTLKIAHQTIANMQARLNQKEEVLKKYQRLLEKARE--EQ 1570
Query: 504 NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLND----------EKKRVHQLEDDKMDI 553
+ KH + + + + DS ++K KQ D K +L + + +
Sbjct: 1571 REIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTV 1630
Query: 554 TKELDVQKEKLIQSEVALNDLHLTKQKLEDKV---ENLVDQLNKSQESNVSIQKENLE-L 609
++ D L++ + DL ++ E KV EN+ QL ++ E V K +E L
Sbjct: 1631 AEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDL 1690
Query: 610 KEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLK 669
K + Q+++E +++EL +++NS T ++ V LK L+ E+ + L
Sbjct: 1691 KYLLDQSQKESQCLKSELQAQ--KEANSRAPTTTMRNL---VERLKSQLALKEKQQKALS 1745
Query: 670 KVAFDVKME-----NEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAE 724
+ +++ E E+++ A L N Q ++++T LK + ++
Sbjct: 1746 RALLELRAEMTAAAEERIISATSQKEAHL------NVQQIVDRHT--RELKTQVEDLNEN 1797
Query: 725 LCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ 784
L K+ L N+ + L++ N Q + +++ ++ D E ELK+ I++
Sbjct: 1798 LLKLKEALKTSKNRENSLTDNLNDLNN-ELQKKQKAYNKILREKEEIDQENDELKRQIKR 1856
Query: 785 MDT--DHKETKDVLSSSLEE-QKQLTQLINK-----KEIFIEKLKERSSKLQEELDKYSQ 836
+ + K D S +EE Q+++ +L N+ +E+ ++ +KE+++K EEL ++ +
Sbjct: 1857 LTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEVDLKPMKEKNAK--EELIRWEE 1914
Query: 837 ALR---KNEILRQTIEEKDRSLGSMKEENNHLQE-------ELERLREEQSRTAPVADPK 886
+ K E +R ++EK+ + ++ ++ N L++ E L+ + T D
Sbjct: 1915 GKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQV 1974
Query: 887 TLDSVTELASEVSQLNTIKEHLEEEIKH---HQ-----KIIEDQNQSKMQLLQSLQEQKK 938
E E+ +L LE +I + HQ ++ED + L + L +K
Sbjct: 1975 LGIRALESEKELEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEK 2034
Query: 939 EMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETK 998
+ + Y ++ + ++++E LQK ++ ++ E + ++ N D+ K
Sbjct: 2035 QFSKDTYSKPSISGIESDDHCQREQE---LQKENLKLSSENIELKFQLEQANKDL-PRLK 2090
Query: 999 VQSLNIENGSEKHDLSKAETERLV----------KGIKERELEIKLLNE-------KNIS 1041
Q +++ E KAE +R + K I E E I L+ + +N
Sbjct: 2091 NQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQ 2150
Query: 1042 LTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKV 1101
L K L+ +++ + Q ++ E++ L A + L ++ EK+
Sbjct: 2151 LKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQ--------LSMHYESKTKGTEKI 2202
Query: 1102 FAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDM-FRETIQ 1160
A EN L+ E K D A L+ N+K++ + E +G+ + F E+
Sbjct: 2203 IA-------ENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAES-- 2253
Query: 1161 NLSRIIREKDIE-IDALSQKCQTLLAVLQTSSTGNEAGGVNSNQ----FEELLQERDKLK 1215
R +E D+ S K + + +T E NQ ++L++E + +
Sbjct: 2254 ------RGPQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATERE 2307
Query: 1216 QQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYE 1275
Q+V K E +Q + ++++ + Q +LQ L N +L + LI E
Sbjct: 2308 QKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLRLA----NHQLDKEKAELIHQIE 2363
Query: 1276 QNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKS 1335
N+ Q D L K+ + QL + L E ++ K
Sbjct: 2364 ANKD------------QSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKK 2411
Query: 1336 EV-------LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1388
E+ E +L EE++K++ ++ + ++ L+ +AA+ E E +E
Sbjct: 2412 ELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVELTSPVAASEEFEDEEE 2471
Query: 1389 EQTDSEI 1395
+ I
Sbjct: 2472 SPVNFPI 2478
Score = 108 bits (270), Expect = 5e-23
Identities = 202/915 (22%), Positives = 399/915 (43%), Gaps = 135/915 (14%)
Query: 47 AELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIK-------QQSTSYRNQ 99
AE+ + ++ +++ ++L +LKK+ DLE + E +E+++K Q ++ ++
Sbjct: 1624 AEMEQTVAEQDDSLSSLL----VKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDE 1679
Query: 100 LQQKEVEISHLK--ARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAF 157
+++ + E+ LK Q + Q LK + AQ + + P TT + S
Sbjct: 1680 VKKVKAEVEDLKYLLDQSQKESQCLKSELQAQK-EANSRAPTTTMRNLVERLKSQLALKE 1738
Query: 158 HDDDMDFGDIISSQQEI-----NRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSE-I 211
++ + E+ R+ + S+ E+ + + + + ++ T D +E +
Sbjct: 1739 KQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENL 1798
Query: 212 CKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHRE---ELSDYEERIEEL 268
KL+ +K K NR + D+ ++++ Q+ +I R E E + + +I+ L
Sbjct: 1799 LKLKEALKTSK-NRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRL 1857
Query: 269 ENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAEND 328
+ LQ G + + S I E+Q+ ++ L+ QLE K+++++ K +N
Sbjct: 1858 TSGLQ--GKPLTDNKQSLIEELQRKVKKLE----------NQLEGKVEEVDLKPMKEKNA 1905
Query: 329 RDILRREQE----QLNVEK-RQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQ--- 380
++ L R +E Q +E R ++E E +K Q + +K +KE++ Q
Sbjct: 1906 KEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTK-QLNTLKDLFAKADKEKLTLQRKL 1964
Query: 381 ---SASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQE 437
+V++V ++ S+ E E ++ +L+ +N + L MR S++
Sbjct: 1965 KTTGMTVDQVLGIRALESEKELEELKKRNLDLENDI------LYMRAHQALPRDSVVED- 2017
Query: 438 KEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSIS--EKETLIA 495
L L N Y L +LH L +K+ SIS E +
Sbjct: 2018 --------LHLQNRY------------LQEKLHALEKQF-SKDTYSKPSISGIESDDHCQ 2056
Query: 496 EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITK 555
+EL ++N + + I +K QL + + + +LK + D K+ L+ +K ++ +
Sbjct: 2057 REQELQKENLKLSSENIELKFQLEQANKD----LPRLKNQVRDLKEMCEFLKKEKAEVQR 2112
Query: 556 ELDVQKEKLIQSEVALNDLHLT---KQKLEDKVENLVDQLNK-----SQESNVSIQKENL 607
+L + +S + +L T +K+ +KV+ +QL K + E +I++EN
Sbjct: 2113 KLGHVRGS-GRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENE 2171
Query: 608 ELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNEN 667
+LK EL +++ L L+ S K T ++ AE L++ L + E
Sbjct: 2172 KLK-------AELEKLKAHLGHQLSMHYESKTKGT--EKIIAENERLRKELKKETDAAEK 2222
Query: 668 LKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQL----SLEKNTIVETLKMEKGEIEA 723
L+ ++++ NEK+ + E+ +L+ + QL S +IV T E E
Sbjct: 2223 LRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQLEGADSKSWKSIVVTRMYETKLKEL 2282
Query: 724 ELCWAK--------KRLLEEA-------NKYEKTIE-ELSNARNLNTSA-----LQLEHE 762
E AK K+L++EA NKY + +E ++ +++ A L+ E +
Sbjct: 2283 ETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQ 2342
Query: 763 HLIKLNQKKDMEIAELKKNIE-QMDTDHKETKDVLSSSLEEQ-KQLTQLINKKEIFIEKL 820
L N + D E AEL IE D E+ + L+E+ K L + ++ + L
Sbjct: 2343 VLRLANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHL 2402
Query: 821 KERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREE--QSR 878
KE KL++EL+ + + + IE+ + ++N L+E++++L E+
Sbjct: 2403 KEEIKKLKKELENFDPS------FFEEIEDLKYNYKEEVKKNILLEEKVKKLSEQLGVEL 2456
Query: 879 TAPVADPKTLDSVTE 893
T+PVA + + E
Sbjct: 2457 TSPVAASEEFEDEEE 2471
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 181 bits (459), Expect = 6e-45
Identities = 269/1281 (20%), Positives = 550/1281 (42%), Gaps = 212/1281 (16%)
Query: 542 RVHQLEDDKMDITKELDVQKEKLIQSEVALNDLH-LTKQKLEDKVENLVDQLNKSQESNV 600
+V + E++ M +EL +EK + +E L ++ L Q + +K+ QL + ++
Sbjct: 839 QVSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKL-----QLQEQLQAET 893
Query: 601 SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSE 660
+ E EL+ + ++EL I ++L + ++ + +AE + ++QN+ E
Sbjct: 894 ELCAEAEELRARLTAKKQELEEICHDLEARVEEEEER------CQHLQAEKKKMQQNIQE 947
Query: 661 LEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGE 720
LE+ E + +++E + E +LEE Q+ LE L EK
Sbjct: 948 LEEQLEEEESARQKLQLEK----VTTEAKLKKLEE-----EQIILEDQNC--KLAKEKKL 996
Query: 721 IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
+E + L EE K K++ +L N A+ + E ++ +K+ E+ + ++
Sbjct: 997 LEDRIAEFTTNLTEEEEK-SKSLAKLKNKHE----AMITDLEERLRREEKQRQELEKTRR 1051
Query: 781 NIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
+E TD + L + + E K QL K+E +L+ ++++EE + + AL+K
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKM--QLAKKEE----ELQAALARVEEEAAQKNMALKK 1105
Query: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVT---ELASE 897
L I E L S + N +++ L EE + TLDS EL S+
Sbjct: 1106 IRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELED-TLDSTAAQQELRSK 1164
Query: 898 VSQ-LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQ 956
Q +N +K+ LEEE K H+ I++ Q Q ++ L EQ
Sbjct: 1165 REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQ-------------------- 1204
Query: 957 LFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKA 1016
L++T +++K L + +Q ++ + ++ E KV L G +H K
Sbjct: 1205 -----------LEQT-KRVKANLEKAKQTLENERGELANEVKV--LLQGKGDSEHKRKKV 1250
Query: 1017 ETERLVKGIKERELEIKLLNEKNISLTKQIDQLSK--DEVGKLTQIIQQKDLEIQALHAR 1074
E + +EL++K NE T+ D+++K E+ +T ++ Q D +
Sbjct: 1251 EAQL-------QELQVKF-NEGERVRTELADKVTKLQVELDNVTGLLSQSDSK------- 1295
Query: 1075 ISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI 1134
S+ T+D L+ QLQ +L E+ R+ L T+ L
Sbjct: 1296 --SSKLTKDFSALESQLQ-------DTQELLQEENRQKLSLSTK--------------LK 1332
Query: 1135 KLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGN 1194
+++DE + E E NL + I ++ + +K + + L+T+
Sbjct: 1333 QVEDEKNSFREQLEEE-----EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAE--- 1384
Query: 1195 EAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVL 1254
+ + KL++ ++ + + ++ + ++ +LQ+EL L L
Sbjct: 1385 --------------EVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDL----L 1426
Query: 1255 VDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQ---HSIGQLCNTKDLLLGK-LD 1310
VD D+ + + + ++Q + K + A+ + + + TK L L + L+
Sbjct: 1427 VDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALE 1486
Query: 1311 IISPQLSSASLLTPQ---SAECLRASKSEV------LSESSELLQQELEELRKSLQEKDA 1361
Q + L Q E L +SK +V L +S L+Q++EE++ L+E +
Sbjct: 1487 EAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELED 1546
Query: 1362 TIRTLQENNHRLSDSIAAT-SELER-------KEHEQTDSEIKQLKEKQDVLQKLLKEKD 1413
++ ++ RL ++ A ++ ER + E+ ++Q++E + L+ K++
Sbjct: 1547 ELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRS 1606
Query: 1414 LLIKA--KSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVET 1471
+ + A K + L E + N+N E I L ++K ++ +T
Sbjct: 1607 MAVAARKKLEMDLKDLEAHIDSANKNR---------DEAIKQLRKLQAQMKDCMRELDDT 1657
Query: 1472 YRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNA 1531
+E +E K L+ E E ++E+ A E+ ++ +Q E ++L +
Sbjct: 1658 RASREEILAQAKENEKK----LKSMEAEMIQLQEELAAAERAKRQAQQ----ERDELADE 1709
Query: 1532 VKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERL------- 1584
+ + K + +E+ ++ + Q + E Q + + D+ ++N +++++
Sbjct: 1710 IANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLE 1769
Query: 1585 RNHLLESEDSYTREALAAEDRE--AKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
R+H ++E++ R+ L +++E KL++ ++ K +S A+E ++ L+
Sbjct: 1770 RSHAQKNENA--RQQLERQNKELKVKLQEMEGTVKSKYKASITALE-------AKIAQLE 1820
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ-QEEKAMYSAELEKQKQL 1701
EQL+ +K+R Q+ +++++K L + + + E ++ Q +KA S L++ K+
Sbjct: 1821 EQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKA--STRLKQLKRQ 1878
Query: 1702 IAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEML 1761
+ E ++ A+ LQ L++A TE D ++ LK N+LR+ L
Sbjct: 1879 LEEAEEEAQRANASRRKLQRELEDA----------TETADAMNREVSSLK--NKLRRGDL 1926
Query: 1762 DDVQKKLMSLANSSEGKVDKV 1782
V + M+ + +G ++V
Sbjct: 1927 PFVVPRRMARKGAGDGSDEEV 1947
Score = 171 bits (433), Expect = 7e-42
Identities = 257/1157 (22%), Positives = 503/1157 (43%), Gaps = 168/1157 (14%)
Query: 406 SLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL 465
S ++ +A++ +K+R + L E L E + Q+ KL + ++ T L
Sbjct: 841 SRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET-----EL 895
Query: 466 DSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEG 525
+E +LR L AK+QEL + + E + E EE + Q K M QQN
Sbjct: 896 CAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKM---------QQN-- 944
Query: 526 DSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLH--LTKQK--L 581
I +L++ L +E+ +L+ +K+ +L +KL + ++ L D + L K+K L
Sbjct: 945 ---IQELEEQLEEEESARQKLQLEKVTTEAKL----KKLEEEQIILEDQNCKLAKEKKLL 997
Query: 582 EDKVENLVDQLNKSQESNVSIQKEN-------LELKEHIRQNE---EELSRIRNELMQSL 631
ED++ L + +E + S+ K +L+E +R+ E +EL + R +L
Sbjct: 998 EDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL---- 1053
Query: 632 NQDSNSNFKDTLLKEREAEVRNLKQNLSEL-EQLNENLKKVAFDVKMEN------EKLVL 684
+ +S + E +A++ LK L++ E+L L +V + +N +L
Sbjct: 1054 --EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 685 ACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI-----------------EAELCW 727
+++ LE A N+ +K + E L+ K E+ E E+
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 728 AKKRLLEEANKYEKTIEEL--SNARNLNTSALQLEHEHLIKLNQKK-----DMEIAELKK 780
KK L EEA +E I+E+ +++ + A QLE +K N +K + E EL
Sbjct: 1172 LKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELAN 1231
Query: 781 NIEQM-----DTDHKETKDVLSSSLEEQKQLTQL-INKKEIFIEKLKERSSKLQEELDKY 834
++ + D++HK K +E Q Q Q+ N+ E +L ++ +KLQ ELD
Sbjct: 1232 EVKVLLQGKGDSEHKRKK------VEAQLQELQVKFNEGERVRTELADKVTKLQVELDNV 1285
Query: 835 SQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTEL 894
+ L +++ + + +L S LQ+ E L+EE + + L T+L
Sbjct: 1286 TGLLSQSDSKSSKLTKDFSALES------QLQDTQELLQEE--------NRQKLSLSTKL 1331
Query: 895 ASEVSQLNTIKEHL--EEEIKHH-QKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMN 951
+ N+ +E L EEE KH+ +K I + + + +++ ++ ++
Sbjct: 1332 KQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQ 1391
Query: 952 ATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKH 1011
L +E++ + K +E+ KT+L +E D+ D + + N+E +K
Sbjct: 1392 KDLEGLSQRHEEKVAAYDK-LEKTKTRLQQELDDLLVD----LDHQRQSACNLEKKQKKF 1446
Query: 1012 DLSKAETERL-VKGIKER---ELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLE 1067
D AE + + K +ER E E + K +SL + +++ ++ E
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEE------------AMEQKAE 1494
Query: 1068 IQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVA 1127
++ L+ + + +D++ + + E EK L ++ E +KT+ ++ D +
Sbjct: 1495 LERLNKQF--RTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEE---MKTQLEELEDELQ 1549
Query: 1128 AKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIRE-KDIEIDALSQKCQTLLAV 1186
A E A ++L+ + + +FE Q ++ + +++R+ +++E + ++ Q +AV
Sbjct: 1550 ATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAV 1609
Query: 1187 -----LQTSSTGNEA--GGVNSNQFEELLQERDKLKQQVKK-MEEW------KQQVMTTV 1232
L+ EA N N+ E + Q R KL+ Q+K M E +++++
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLR-KLQAQMKDCMRELDDTRASREEILAQA 1668
Query: 1233 QNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQ 1292
+ + + ++ E+ QLQ ++ + Q + L + K +E +++
Sbjct: 1669 KENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLE 1728
Query: 1293 HSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELE-- 1350
I QL + G ++I+ +L A+L Q L +S ++ +E +Q+LE
Sbjct: 1729 ARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSH--AQKNENARQQLERQ 1786
Query: 1351 --ELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKL 1408
EL+ LQE + T+++ + SI A + EQ D+E KE+Q +++
Sbjct: 1787 NKELKVKLQEMEGTVKS------KYKASITALEAKIAQLEEQLDNE---TKERQAACKQV 1837
Query: 1409 LKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKI 1468
+ + K D LL ++ N + +A T LK+ L+ + + + E ++
Sbjct: 1838 RRTE----KKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ----LKRQLEEAEEEAQRA 1889
Query: 1469 VETYRGKETEYQALQET 1485
+ R + E + ET
Sbjct: 1890 NASRRKLQRELEDATET 1906
Score = 159 bits (402), Expect = 3e-38
Identities = 270/1262 (21%), Positives = 532/1262 (42%), Gaps = 240/1262 (19%)
Query: 56 EIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQI 115
+++ + + R E E + K E ++++++ + N+L + E S L A ++
Sbjct: 833 KVKPLLQVSRQEEEMMAK---------EEELVKVREKQLAAENRLTEMETLQSQLMAEKL 883
Query: 116 ALQDQLLKLQSAAQSVPSGAGVPAT-TASSSFAYGISHHPSAFHDDDMDFGDIISS---- 170
LQ+QL Q+ + + A TA I H A +++ + + +
Sbjct: 884 QLQEQL---QAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKK 940
Query: 171 -QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEI-----CKL-------QNI 217
QQ I L ++ ES + T++A+ ++ I CKL ++
Sbjct: 941 MQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDR 1000
Query: 218 IKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQ--QG 275
I E N ++E ++ ++ L+N H+ +T++ R R E E++ +ELE + +G
Sbjct: 1001 IAEFTTNLTEE-EEKSKSLAKLKNKHEAMITDLEERLRRE----EKQRQELEKTRRKLEG 1055
Query: 276 GSGVIETDLS-KIYEMQKTIQVLQIEKVESTKKMEQLE-----------------DKIKD 317
S TDLS +I E+Q I L K++ KK E+L+ KI++
Sbjct: 1056 DS----TDLSDQIAELQAQIAEL---KMQLAKKEEELQAALARVEEEAAQKNMALKKIRE 1108
Query: 318 INKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERI 377
+ ++S + D + R + + +KR + EE E LK E S Q + +++E
Sbjct: 1109 LESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKRE-- 1166
Query: 378 LAQSASVEEVFRLQQAL-SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQ 436
+EV L++ L +A+ ++ + Q +S A + +L ++E ++ K+ L +
Sbjct: 1167 -------QEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE--ELAEQLEQTKRVKANLEK 1217
Query: 437 EKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAE 496
K+ L+ +L NE +V+ + + R +EA+ QEL +E E + E
Sbjct: 1218 AKQTLENERGELANEVKVL-------LQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTE 1270
Query: 497 IEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKE 556
+ D+++K Q E D++ L Q + K +TK+
Sbjct: 1271 -----------------LADKVTKLQVELDNVTGLLSQSDSKSSK-----------LTKD 1302
Query: 557 LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQN 616
+ +L ++ L + + K L K++ + D+ N +E LE +E + N
Sbjct: 1303 FSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSF--------REQLEEEEEAKHN 1354
Query: 617 -EEELSRIRNELMQSLNQDSNSNFKDTL--LKEREAEVRNLKQNLSELEQLNENLKKVAF 673
E++++ + ++ D +D++ L+ E R L+++L L Q +E +KVA
Sbjct: 1355 LEKQIATLHAQV-----ADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHE--EKVAA 1407
Query: 674 DVKMENEKLVLACE------DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCW 727
K+E K L E D+ HQ + A N + +K + L E+ I A+ +
Sbjct: 1408 YDKLEKTKTRLQQELDDLLVDLDHQRQS--ACNLE---KKQKKFDQLLAEEKTISAK--Y 1460
Query: 728 AKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDT 787
A++R EA EK + LS AR L + + QK ++E L K
Sbjct: 1461 AEERDRAEAEAREKETKALSLARALEEA-----------MEQKAELE--RLNKQFRTEME 1507
Query: 788 DHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT 847
D +KD + S+ E ++ + + ++ +E++K + +L++EL A + E+ Q
Sbjct: 1508 DLMSSKDDVGKSVHELEKSKRALEQQ---VEEMKTQLEELEDELQATEDAKLRLEVNLQA 1564
Query: 848 IEEK-DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKE 906
++ + +R L E++ +++L +R+ + A + D + S+ A ++
Sbjct: 1565 MKAQFERDLQGRDEQSEEKKKQL--VRQVREMEAELEDERKQRSMAVAA---------RK 1613
Query: 907 HLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK 966
LE ++K + I+ N+++ + ++ L++ + +M + + + A+ ++ + E K
Sbjct: 1614 KLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEK 1673
Query: 967 SLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIK 1026
L K++E QL EE + QE + I N S K L+ E RL I
Sbjct: 1674 KL-KSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIA 1732
Query: 1027 ERELEI-------KLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTS 1079
+ E E+ +L+N++ QIDQ++ DL ++ HA+ + +
Sbjct: 1733 QLEEELEEEQGNTELINDRLKKANLQIDQIN-------------TDLNLERSHAQKNENA 1779
Query: 1080 HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAK-EAALIKLQD 1138
+QQL+ R+N LK + +M V +K +A++ L+
Sbjct: 1780 --------RQQLE-----------------RQNKELKVKLQEMEGTVKSKYKASITALEA 1814
Query: 1139 ENKKLSTRFESSGQD------MFRETIQNLSRIIREKDIEIDALSQ------KCQTLLAV 1186
+ +L + ++ ++ R T + L ++ + D E Q K T L
Sbjct: 1815 KIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQ 1874
Query: 1187 LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246
L+ Q EE +E + +K++ + T M E + L+ +L
Sbjct: 1875 LK-------------RQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Query: 1247 HQ 1248
+
Sbjct: 1922 RR 1923
Score = 129 bits (325), Expect = 2e-29
Identities = 196/983 (19%), Positives = 396/983 (40%), Gaps = 162/983 (16%)
Query: 29 QISNFTKDMLMEGTEEVEAELPDSRTK----------EIEAIHAILRSENERLKKLCTDL 78
Q+ T + ++ EE + L D K I L E E+ K L L
Sbjct: 963 QLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAK-L 1021
Query: 79 EEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVP 138
+ KHEA ++++ Q Q+ E L+ L DQ+ +LQ+ +
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAEL------- 1074
Query: 139 ATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTS 198
A +A + + + ++I L +++S L+ ++ R +
Sbjct: 1075 ----KMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKA 1130
Query: 199 KAQGTDNSDQSEICK--LQNII------KELKQNRSQEIDDHQHEMSVLQNAHQQKLTEI 250
+ Q D ++ E K L++ + +EL+ R QE++ + + H+ ++ E+
Sbjct: 1131 EKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEM 1190
Query: 251 SRRHREELSDYEERIEELENLLQ--QGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKM 308
++H + + + E++E+ + + + +E + E+ ++VL K +S K
Sbjct: 1191 RQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERG---ELANEVKVLLQGKGDSEHKR 1247
Query: 309 EQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQS 368
+++E +++++ K + E R L + +L VE + + SKL
Sbjct: 1248 KKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALE 1307
Query: 369 DTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNL---------- 418
+ + + +L + + L L E+E ++ A+ NL
Sbjct: 1308 SQLQDTQELLQEEN--RQKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQ 1365
Query: 419 ----KLKMR-----IEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSEL 469
K KM +E E+ K L ++ E L + Y+ ++ T TR L EL
Sbjct: 1366 VADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTR---LQQEL 1422
Query: 470 HDLRL----------NLEAKEQELNQSISEKETLIAEI-EELDRQNQEA----TKHMILI 514
DL + NLE K+++ +Q ++E++T+ A+ EE DR EA TK + L
Sbjct: 1423 DDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLA 1482
Query: 515 K--DQLSKQQNEGDSIISKLKQDL-------NDEKKRVHQLEDDKMDITKELDVQKEKLI 565
+ ++ +Q+ E + + + + ++ +D K VH+LE K + ++++ K +L
Sbjct: 1483 RALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLE 1542
Query: 566 QSEVALNDLHLTKQKLEDKVENLVDQLNKS-QESNVSIQKENLELKEHIRQNEEELSRIR 624
+ E L K +LE ++ + Q + Q + +++ +L +R+ E EL R
Sbjct: 1543 ELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDER 1602
Query: 625 NELMQSL---------------NQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLK 669
+ ++ + DS + +D +K+ +K + EL+ + +
Sbjct: 1603 KQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASRE 1662
Query: 670 KVAFDVKMENEKLVLACEDVRHQLEECLAG----NNQLSLEKNTIVETLKM--------- 716
++ K ENEK + + E QL+E LA Q E++ + + +
Sbjct: 1663 EILAQAK-ENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALAL 1721
Query: 717 -EKGEIEAELCWAKKRLLEEANKYEKTIEELSNAR----NLNTSALQLEHEH-------- 763
EK +EA + ++ L EE E + L A +NT L LE H
Sbjct: 1722 EEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTD-LNLERSHAQKNENAR 1780
Query: 764 --LIKLNQKKDMEIAELKKNI-------------------EQMDTDHKET---------- 792
L + N++ +++ E++ + EQ+D + KE
Sbjct: 1781 QQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNETKERQAACKQVRRT 1840
Query: 793 ----KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTI 848
KDVL +E++ Q ++ + +LK+ +L+E ++ +A L++ +
Sbjct: 1841 EKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQRANASRRKLQREL 1900
Query: 849 EEKDRSLGSMKEENNHLQEELER 871
E+ + +M E + L+ +L R
Sbjct: 1901 EDATETADAMNREVSSLKNKLRR 1923
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 180 bits (457), Expect = 1e-44
Identities = 288/1381 (20%), Positives = 592/1381 (42%), Gaps = 225/1381 (16%)
Query: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIK--DINKKLSSAENDRDILRREQEQLNVEKRQI 346
E++K + +L V+ KK E +E +I+ D + K + A + +++ ++ +++ ++
Sbjct: 120 EVKKLLLLLLGCAVQCQKKEEFIE-RIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEV 178
Query: 347 MEECE--------NLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAE 398
+ + N+ L +L + S+T+ E S + + L A S A+
Sbjct: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL------SEERDGLHFLPHASSSAQ 232
Query: 399 NEI----MRLSSLNQDNS--LAEDNLKLK-MRIEVLEKEKSLLS--QEKEELQMSLLKLN 449
+ M+ + Q S LA+ K++ +R E+ EK + LL QE E++++ L +L
Sbjct: 233 SPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ 292
Query: 450 NEYEVIKSTATRDISLDSELHDLRLN------LEAKEQELNQSISEKETLIAEIEELDRQ 503
E + S A EL LR LE++ + + + E A +EEL
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
Query: 504 NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDK-MDITKELDVQKE 562
NQ + +++DQL + D + K++L K ++H +E ++ MD K ++ +E
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEE 411
Query: 563 ----KLIQSEVALNDLHL---------TKQKLEDKVENLVDQLNKSQESNV-SIQKENLE 608
++ Q + LHL T + E ++L ++N+ S + ++ EN
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQS 471
Query: 609 LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENL 668
L + + + + + + L + + ++ E E+ KQ+L + L+++L
Sbjct: 472 LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 669 KKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
K E +L E +R E + Q + N V +L+ ++ +I AE A
Sbjct: 532 MK-------EKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR-QRSQISAE---A 580
Query: 729 KKRLLEEANK-----------------YEKTI--EELSNARNLNTSALQLEHE--HLIKL 767
+ + +E+ NK +EK +EL + + A +LE+E HL K
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 827
N+ +I LK E+++ +E ++ + + +K L N +E L++ +S+L
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQL 699
Query: 828 QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKT 887
EE + LR+N ++++ + ++ EN L+ E E+L+ K
Sbjct: 700 DEE----NLELRRNV---ESLKCASMKMAQLQLENKELESEKEQLK------------KG 740
Query: 888 LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947
L+ + + +L + L+ E + QK +E+ N+ QL LQ+ + E +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENG 1007
E++ + +L E+++ K++EQ +QL ++++ ++ +N + Q+ +++ +E
Sbjct: 801 EELKISSKRL-----EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Query: 1008 SEKHDLSKAETERLVKGI---KERELEIKLLNEKNISLTKQ--ID--------------- 1047
+ K + E + L K I KE + +K L ++N L K+ ID
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK 915
Query: 1048 ---QLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVY--LQQQLQAYAMEREKVF 1102
Q +++ KLT +++ L + L ST ++ L+ L+ +E+
Sbjct: 916 LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKI 975
Query: 1103 AVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQD--MFRETIQ 1160
A L + E+++ + + + V AL + QDE + + + SG+D RE+ +
Sbjct: 976 AALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQE 1035
Query: 1161 NLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKK 1220
+++ KD L+ V + ++T L E+ LK Q+K+
Sbjct: 1036 TTRELLKVKD-----------RLIEVERNNAT--------------LQAEKQALKTQLKQ 1070
Query: 1221 MEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETK 1280
+E + + +Q ++ LQE+ LQ Q N+KLQV+ + L T
Sbjct: 1071 LETQNNNLQAQILALQRQTVSLQEQNTTLQTQ-------NAKLQVENSTL----NSQSTS 1119
Query: 1281 LKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLS- 1339
L N +L Q S L + + + E L++ ++
Sbjct: 1120 LMNQNAQLLIQQSS---------------------LENENESVIKEREDLKSLYDSLIKD 1158
Query: 1340 -ESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQL 1398
E ELL + +SL K T+++ +N E+E ++ E +++ +
Sbjct: 1159 HEKLELLHERQASEYESLISKHGTLKSAHKN-----------LEVEHRDLEDRYNQLLKQ 1207
Query: 1399 KEKQDVLQKLLK--EKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEM 1456
K + + L+K+LK ++ +L++ K+ + +++ + EN+ L + L + +L+
Sbjct: 1208 KGQLEDLEKMLKVEQEKMLLENKNHETVAA--EYKKLCGENDRLNHTYSQLLKETEVLQT 1265
Query: 1457 DIGKLKG--ENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLL 1514
D LK N K+ +T E E+ L+E + + + +C +LL
Sbjct: 1266 DHKNLKSLLNNSKLEQT--RLEAEFSKLKEQYQQLDITSTKLNNQC-----------ELL 1312
Query: 1515 KEKEQGKTGELNQLLNAVKS--MQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRD 1572
+ + E LL+ +++ +Q +T++ Q + + ++Q+Q + NE++R ++
Sbjct: 1313 SQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL--NELRRQKE 1370
Query: 1573 K 1573
K
Sbjct: 1371 K 1371
Score = 157 bits (398), Expect = 7e-38
Identities = 259/1246 (20%), Positives = 519/1246 (41%), Gaps = 184/1246 (14%)
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+ LS + + + I +L+Q+L + + QL D K ++ ++++++ ++L Q + L
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEE---KTEQLLDCKQEL-EQMEIELKRLQQENMNLLSD 301
Query: 575 HLTKQKLEDKVENLVDQLNKSQ--ESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLN 632
+ + D+++ L ++ + ES VS KE L E + EEL L+++
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-- 359
Query: 633 QDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQ 692
T+L+++ R L ELE+ N LK D++ME + R +
Sbjct: 360 --------KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM-------DRKK 404
Query: 693 LEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA--R 750
+EE + E+N +E + + + L W LE+ ++ ELS A +
Sbjct: 405 IEELM--------EENMTLEMAQKQSMDESLHLGWE----LEQISR----TSELSEAPQK 448
Query: 751 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLI 810
+L +L L+KL +ME L K +E++ T + S L+ +K+ +L
Sbjct: 449 SLGHEVNELTSSRLLKL----EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLS 504
Query: 811 NKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE----EKDRSLGSMKEENNHLQ 866
K EI ++ + LQ + +++ L +TIE +R + +++EN HL
Sbjct: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
Query: 867 EELERLREEQSRTAPVA------DPKTL-DSVTELASEVSQLNTIKEHLEEEIKHHQKII 919
+ + LR+ +A + K L +S+ E +S++S++ K +++E++H++
Sbjct: 565 QTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK--- 621
Query: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
++ + +L L +KE + Q T+ ++ EK E +EQ ++L
Sbjct: 622 -EKGERAEELENELHHLEKENELL-----QKKITNLKITCEKIE-------ALEQENSEL 668
Query: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKN 1039
E + ++ D F+ Q ++E + + D E R V+ +K +++ L +N
Sbjct: 669 ERENRKLKK-TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 1040 ISLTKQIDQLSKD---------EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
L + +QL K + +L Q D+E Q L + +++ + + L+ +
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--KKIQQLESE 785
Query: 1091 LQAYAMEREKVFAVLNE---KTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRF 1147
LQ ME + + L E ++ L+ E + + E +L+ ENK+L
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRL---- 841
Query: 1148 ESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSN--QFE 1205
R+ + + E +++I L ++ +TL E G + + +
Sbjct: 842 --------RQQAEIKDTTLEENNVKIGNLEKENKTL---------SKEIGIYKESCVRLK 884
Query: 1206 ELLQERDKLKQQ----VKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNS 1261
EL +E +L ++ +K + ++ +++ Q + L++ H+L+ L N
Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGL----NKE 940
Query: 1262 KLQVDYTGLIQSYEQNETKLKNF--------GQELAQVQHSIGQLCNTKDLLLGKLDIIS 1313
+L D Y+ E+KL++ +++A ++ + + N L +L +
Sbjct: 941 RLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVK 1000
Query: 1314 PQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRL 1373
+ L Q E + S + E ++ ++ E R+ L+ KD I ++ NN L
Sbjct: 1001 KNYEA--LKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE-VERNNATL 1057
Query: 1374 SDSIAATSELERKEHEQTDSEIKQLKEKQDVLQ-KLLKEKDLLIKAKSDQLLSSNENFTN 1432
+ E + +++KQL+ + + LQ ++L + + + +N
Sbjct: 1058 -----------QAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKL 1106
Query: 1433 KVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMM 1492
+V EN L T+L + L + L+ ENE +++ ++ Y +L + + K ++
Sbjct: 1107 QV-ENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELL 1165
Query: 1493 LREKEFECHSM------------------KEKALAFEQLLKEKEQGKTGELNQLLNAVKS 1534
+ E S+ ++ + QLLK+K G+L L +K
Sbjct: 1166 HERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK-----GQLEDLEKMLKV 1220
Query: 1535 MQEKTVVFQQERDQVMLALKQKQMENTAL---------QNEVQRLRDKEFRSNQELERLR 1585
QEK ++ + + V K+ EN L + EV + K +S +L
Sbjct: 1221 EQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLE 1280
Query: 1586 NHLLESEDSYTREALAAED-REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQ 1644
LE+E S +E D KL + +L + +E + Q+++L Q
Sbjct: 1281 QTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ----LKGNLEEENRHLLDQIQTLMLQ 1336
Query: 1645 LNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAM 1690
+ +Q E+ V Q +QY L L+ E + EEK M
Sbjct: 1337 NRTLLEQNMESKDLFHVEQ---RQYIDKLNELRRQKE--KLEEKIM 1377
Score = 154 bits (390), Expect = 6e-37
Identities = 268/1233 (21%), Positives = 523/1233 (42%), Gaps = 199/1233 (16%)
Query: 37 MLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQ---QS 93
+L+E +E +L +R + + +H L EN +LK D+E + + +I++ ++
Sbjct: 355 VLLETKTMLEDQLEGTRARS-DKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 94 TSYRNQLQQKEVEISHL--KARQIALQDQLLK-----LQSAAQSVPSGAGVPATTASSSF 146
+ +Q E HL + QI+ +L + L + S + + S
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 147 AYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
+ + + + I+ ++E RLS +V LE+E+ + Q Q
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQN--CQNLSKD 530
Query: 207 DQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE 266
E +L+ I+ L++N ++I + E N H + T S R R ++S E R++
Sbjct: 531 LMKEKAQLEKTIETLRENSERQIKILEQE-----NEHLNQ-TVSSLRQRSQISA-EARVK 583
Query: 267 ELENLLQQGGSGVIETD--LSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSS 324
++E + + ET LSKI + EK + K++E ++K ++
Sbjct: 584 DIEKENKILHESIKETSSKLSKI----------EFEKRQIKKELEHYKEK----GERAEE 629
Query: 325 AENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASV 384
EN+ L +E E L ++ NLK+ C K++ A++Q ++ E+E
Sbjct: 630 LENELHHLEKENELLQ-------KKITNLKITCEKIE--ALEQENSELEREN-------- 672
Query: 385 EEVFRLQQALSDAENEIMRLSSLNQDNS-LAEDNLKLKMRIEVLEKEKSLLSQ---EKEE 440
+L++ L +N +L SL ++NS L E+NL+L+ +E L+ ++Q E +E
Sbjct: 673 ---RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 441 LQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEEL 500
L+ +L E++K++ + L+ L + + ++ L S + + L +E+++L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 501 DRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ 560
+ +NQ K++ +K + + +L+++ ++ QLE DK + KE
Sbjct: 790 EMENQTLQKNLEELKISSKR--------LEQLEKENKSLEQETSQLEKDKKQLEKE---- 837
Query: 561 KEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKEN-LELKEHIRQNEEE 619
K ++ + + D L + + K+ NL ++ NK+ + I KE+ + LKE ++N+E
Sbjct: 838 -NKRLRQQAEIKDTTLEENNV--KIGNL-EKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 620 LSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMEN 679
+ R ++ TL+ RE +L + +Q+N +L+K+ ++
Sbjct: 894 VKRATIDI-------------KTLVTLRE----DLVSEKLKTQQMNNDLEKLTHEL---- 932
Query: 680 EKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKY 739
EK+ L E + H + + +++ L ++ + TLK + EI+ E A + LEE+ Y
Sbjct: 933 EKIGLNKERLLHDEQ---STDDRYKLLESKLESTLK-KSLEIKEEKIAALEARLEESTNY 988
Query: 740 EKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS- 798
NQ+ E+ +KKN E + E + V SS
Sbjct: 989 ----------------------------NQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1020
Query: 799 ---------SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALR----KNEILR 845
E Q+ +L+ K+ IE ++ ++ LQ E L+ +N L+
Sbjct: 1021 PISGEDNKWERESQETTRELLKVKDRLIE-VERNNATLQAEKQALKTQLKQLETQNNNLQ 1079
Query: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDS-VTELASEVSQLNTI 904
I R S++E+N LQ + +L+ E S TL+S T L ++ +QL
Sbjct: 1080 AQILALQRQTVSLQEQNTTLQTQNAKLQVENS---------TLNSQSTSLMNQNAQLLIQ 1130
Query: 905 KEHLEEEIKHHQKIIED---------QNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHT 955
+ LE E + K ED ++ K++LL + Q E + +H + + H
Sbjct: 1131 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH--ERQASEYESLISKHGTLKSAHK 1188
Query: 956 QLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSK 1015
L +E + + ++Q K QL + + ++ + + E K N E + ++
Sbjct: 1189 NLEVEHRDLEDRYNQLLKQ-KGQLEDLEKMLKVEQEKMLLENK----NHETVAAEYKKLC 1243
Query: 1016 AETERLVKGIKE--RELEIKLLNEKNISLTKQIDQLSKD----EVGKLTQIIQQKDLEIQ 1069
E +RL + +E E+ + KN+ +L + E KL + QQ D+
Sbjct: 1244 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1303
Query: 1070 ALHARISSTSH-----TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH--KM 1122
L+ + S ++ +L Q+Q M + + N ++++ H++ + K+
Sbjct: 1304 KLNNQCELLSQLKGNLEEENRHLLDQIQT-LMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1362
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQT 1182
++ KE K+ D+ K S + + ++I+ K +I+ QK T
Sbjct: 1363 NELRRQKEKLEEKIMDQYKFYD---PSPPRRRGNWITLKMRKLIKSKK-DINRERQKSLT 1418
Query: 1183 LLAVLQTSSTG---------NEAGGVNSNQFEE 1206
L SS G ++ V SN E+
Sbjct: 1419 LTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED 1451
Score = 127 bits (320), Expect = 8e-29
Identities = 252/1255 (20%), Positives = 509/1255 (40%), Gaps = 196/1255 (15%)
Query: 669 KKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV-ETLKMEKGEIEAELCW 727
KKV D + L + ++ +E L +SL I+ + E+G E
Sbjct: 66 KKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEV---- 121
Query: 728 AKKRLL------EEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD-----MEIA 776
KK LL + K E+ IE + + +T A H + NQ+ ME+
Sbjct: 122 -KKLLLLLLGCAVQCQKKEEFIERIQGL-DFDTKAAVAAHIQEVTHNQENVFDLQWMEVT 179
Query: 777 E----------------LKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKL 820
+ LK+ I++ D +H ET LS + L + +
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERD-EHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
Query: 821 KERSSKLQEELD-KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRT 879
+ ++ ++ L + + A K LRQ +EEK L K+E ++ EL+RL++E
Sbjct: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Query: 880 APVADPKT-------LDSVTELASEV----SQLNTIKEHLE---------EEIKHHQKII 919
++D ++ LD++ E A V S+++ KE L EE+K +++
Sbjct: 299 --LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVL 356
Query: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
+ L+ + + ++ E ++ Q+ A + +E+D + K ++ +L
Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE--------EL 408
Query: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKE-RELEIKLLNEK 1038
EE ++ E+ +E S +LS+A + L + E + L +
Sbjct: 409 MEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
Query: 1039 NISLTKQIDQL---------SKDEVGKLTQIIQQKDLEIQALHARISSTSHT-QDVVYLQ 1088
N SLTK +++L + ++ K+ + Q+ +++ L I + Q+ L
Sbjct: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS 528
Query: 1089 QQLQAYAMEREKVFAVLNEKT--------RENSHLKTEYHKMMDIVAAKEAALIK-LQDE 1139
+ L + EK L E + +EN HL + A +K ++ E
Sbjct: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 1140 NKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGV 1199
NK L + +ET LS+I EK + + L+ E
Sbjct: 589 NKIL--------HESIKETSSKLSKIEFEK-----------RQIKKELEHYKEKGERAEE 629
Query: 1200 NSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDN 1259
N+ L +E + L++++ ++ +++ + ++ E+++L+ E +L+ + DS
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKI----EALEQENSELERENRKLKKTL--DSFK 683
Query: 1260 NSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSA 1319
N Q ++S E+ ++L EL + S+ + + +L + + +L S
Sbjct: 684 NLTFQ------LESLEKENSQLDEENLELRRNVESL----KCASMKMAQLQLENKELESE 733
Query: 1320 SLLTPQSAECLRAS--KSEVLSES-------SELLQQELEELRKSLQEKDATIR------ 1364
+ E L+AS K+E L S ++ LQ+ LE K +Q+ ++ ++
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 1365 -TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
TLQ+N L S +LE KE++ + E QL++ + L+K K + K L
Sbjct: 794 QTLQKNLEELKISSKRLEQLE-KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVET----YRGKETEY 1479
+N N EN+ L + + KE + L+ +L+ EN+++V+ + T
Sbjct: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLK----ELEKENKELVKRATIDIKTLVTLR 908
Query: 1480 QALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKT 1539
+ L +K M + E H +++ L E+LL + EQ L + ++S +K+
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHD-EQSTDDRYKLLESKLESTLKKS 967
Query: 1540 VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREA 1599
+ ++E+ +A + ++E + N+ R K + N E + R
Sbjct: 968 LEIKEEK----IAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-------------- 1009
Query: 1600 LAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQL 1659
+D E ++ + E N E S + + ++ ++++L V + +
Sbjct: 1010 ---QDEERMVQSSPPISGE-----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1061
Query: 1660 SVSQEQVKQYALSLANLQMVLEHFQQEEKAM---------YSAELEKQKQLIAEWKKNAE 1710
+ Q+KQ NLQ + Q++ ++ +A+L+ + + +
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1121
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMS 1770
N +++ Q L+ N ++ + E+ D+K +K +L E+L + Q
Sbjct: 1122 NQNAQLLIQQSSLENENESV-----IKEREDLKSLYDSLIKDHEKL--ELLHERQASEYE 1174
Query: 1771 LANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQ 1825
S G + K +NL + H +++ +++L+ G + E++E++ +Q
Sbjct: 1175 SLISKHGTL-KSAHKNLEVEH-RDLEDRYNQLLKQKGQL-----EDLEKMLKVEQ 1222
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 180 bits (456), Expect = 1e-44
Identities = 287/1383 (20%), Positives = 590/1383 (42%), Gaps = 228/1383 (16%)
Query: 289 EMQKTIQVLQIEKVESTKKMEQLEDKIK--DINKKLSSAENDRDILRREQEQLNVEKRQI 346
E++K + +L V+ KK E +E +I+ D + K + A + +++ ++ +++ ++
Sbjct: 120 EVKKLLLLLLGCAVQCQKKEEFIE-RIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEV 178
Query: 347 MEECE--------NLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAE 398
+ + N+ L +L + S+T+ E S + + L A S A+
Sbjct: 179 TDMSQEDIEPLLKNMALHLKRLIDERDEHSETIIEL------SEERDGLHFLPHASSSAQ 232
Query: 399 NEI----MRLSSLNQDNS--LAEDNLKLK-MRIEVLEKEKSLLS--QEKEELQMSLLKLN 449
+ M+ + Q S LA+ K++ +R E+ EK + LL QE E++++ L +L
Sbjct: 233 SPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQ 292
Query: 450 NEYEVIKSTATRDISLDSELHDLRLN------LEAKEQELNQSISEKETLIAEIEELDRQ 503
E + S A EL LR LE++ + + + E A +EEL
Sbjct: 293 QENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKED 352
Query: 504 NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDK-MDITKELDVQKE 562
NQ + +++DQL + D + K++L K ++H +E ++ MD K ++ +E
Sbjct: 353 NQVLLETKTMLEDQLEGTRARSDKLHELEKENLQ-LKAKLHDMEMERDMDRKKIEELMEE 411
Query: 563 ----KLIQSEVALNDLHL---------TKQKLEDKVENLVDQLNKSQESNV-SIQKENLE 608
++ Q + LHL T + E ++L ++N+ S + ++ EN
Sbjct: 412 NMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQS 471
Query: 609 LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENL 668
L + + + + + + L + + ++ E E+ KQ+L + L+++L
Sbjct: 472 LTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDL 531
Query: 669 KKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
K E +L E +R E + Q + N V +L+ ++ +I AE A
Sbjct: 532 MK-------EKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLR-QRSQISAE---A 580
Query: 729 KKRLLEEANK-----------------YEKTI--EELSNARNLNTSALQLEHE--HLIKL 767
+ + +E+ NK +EK +EL + + A +LE+E HL K
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 768 NQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKL 827
N+ +I LK E+++ +E ++ + + +K L N +E L++ +S+L
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLKKTLDSFKNLT-FQLESLEKENSQL 699
Query: 828 QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKT 887
EE + LR+N ++++ + ++ EN L+ E E+L+ K
Sbjct: 700 DEE----NLELRRNV---ESLKCASMKMAQLQLENKELESEKEQLK------------KG 740
Query: 888 LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947
L+ + + +L + L+ E + QK +E+ N+ QL LQ+ + E +
Sbjct: 741 LELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMENQTLQKNL 800
Query: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENG 1007
E++ + +L E+++ K++EQ +QL ++++ ++ +N + Q+ +++ +E
Sbjct: 801 EELKISSKRL-----EQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEEN 855
Query: 1008 SEKHDLSKAETERLVKGI---KERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQK 1064
+ K + E + L K I KE + +K L ++N L K+ K V ++ +K
Sbjct: 856 NVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEK 915
Query: 1065 DLEIQALHARISSTSH------------------TQDVVY------LQQQLQAYAMEREK 1100
L+ Q ++ + +H T D Y L+ L+ +E+
Sbjct: 916 -LKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEE 974
Query: 1101 VFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQD--MFRET 1158
A L + E+++ + + + V AL + QDE + + + SG+D RE+
Sbjct: 975 KIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNKWERES 1034
Query: 1159 IQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQV 1218
+ +++ KD L+ V + ++T L E+ LK Q+
Sbjct: 1035 QETTRELLKVKD-----------RLIEVERNNAT--------------LQAEKQALKTQL 1069
Query: 1219 KKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNE 1278
K++E + + +Q ++ LQE+ LQ Q N+KLQV+ + L
Sbjct: 1070 KQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ-------NAKLQVENSTL----NSQS 1118
Query: 1279 TKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVL 1338
T L N +L Q S L + + + E L++ ++
Sbjct: 1119 TSLMNQNAQLLIQQSS---------------------LENENESVIKEREDLKSLYDSLI 1157
Query: 1339 S--ESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIK 1396
E ELL + +SL K T+++ +N E+E ++ E +++
Sbjct: 1158 KDHEKLELLHERQASEYESLISKHGTLKSAHKN-----------LEVEHRDLEDRYNQLL 1206
Query: 1397 QLKEKQDVLQKLLK--EKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILIL 1454
+ K + + L+K+LK ++ +L++ K+ + +++ + EN+ L + L + +L
Sbjct: 1207 KQKGQLEDLEKMLKVEQEKMLLENKNHETVAA--EYKKLCGENDRLNHTYSQLLKETEVL 1264
Query: 1455 EMDIGKLKG--ENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQ 1512
+ D LK N K+ +T E E+ L+E + + + +C +
Sbjct: 1265 QTDHKNLKSLLNNSKLEQT--RLEAEFSKLKEQYQQLDITSTKLNNQC-----------E 1311
Query: 1513 LLKEKEQGKTGELNQLLNAVKS--MQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRL 1570
LL + + E LL+ +++ +Q +T++ Q + + ++Q+Q + NE++R
Sbjct: 1312 LLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKL--NELRRQ 1369
Query: 1571 RDK 1573
++K
Sbjct: 1370 KEK 1372
Score = 156 bits (394), Expect = 2e-37
Identities = 254/1234 (20%), Positives = 512/1234 (41%), Gaps = 159/1234 (12%)
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+ LS + + + I +L+Q+L + + QL D K ++ ++++++ ++L Q + L
Sbjct: 246 RQHLSVELADAKAKIRRLRQELEE---KTEQLLDCKQEL-EQMEIELKRLQQENMNLLSD 301
Query: 575 HLTKQKLEDKVENLVDQLNKSQ--ESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLN 632
+ + D+++ L ++ + ES VS KE L E + EEL L+++
Sbjct: 302 ARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVLLET-- 359
Query: 633 QDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQ 692
T+L+++ R L ELE+ N LK D++ME + R +
Sbjct: 360 --------KTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDM-------DRKK 404
Query: 693 LEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA--R 750
+EE + E+N +E + + + L W LE+ ++ ELS A +
Sbjct: 405 IEELM--------EENMTLEMAQKQSMDESLHLGWE----LEQISR----TSELSEAPQK 448
Query: 751 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLI 810
+L +L L+KL +ME L K +E++ T + S L+ +K+ +L
Sbjct: 449 SLGHEVNELTSSRLLKL----EMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLS 504
Query: 811 NKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE----EKDRSLGSMKEENNHLQ 866
K EI ++ + LQ + +++ L +TIE +R + +++EN HL
Sbjct: 505 KKVEILENEIVQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLN 564
Query: 867 EELERLREEQSRTAPVA------DPKTL-DSVTELASEVSQLNTIKEHLEEEIKHHQKII 919
+ + LR+ +A + K L +S+ E +S++S++ K +++E++H++
Sbjct: 565 QTVSSLRQRSQISAEARVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYK--- 621
Query: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
++ + +L L +KE + Q T+ ++ EK E +EQ ++L
Sbjct: 622 -EKGERAEELENELHHLEKENELL-----QKKITNLKITCEKIE-------ALEQENSEL 668
Query: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKN 1039
E + ++ D F+ Q ++E + + D E R V+ +K +++ L +N
Sbjct: 669 ERENRKLKK-TLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLEN 727
Query: 1040 ISLTKQIDQLSKD---------EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
L + +QL K + +L Q D+E Q L + +++ + + L+ +
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSN--KKIQQLESE 785
Query: 1091 LQAYAMEREKVFAVLNE---KTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRF 1147
LQ ME + + L E ++ L+ E + + E +L+ ENK+L +
Sbjct: 786 LQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQA 845
Query: 1148 ESSGQDMFRETIQ--NLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFE 1205
E + ++ NL + + EI + C L + + + + ++
Sbjct: 846 EIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLV 905
Query: 1206 ELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQV 1265
L + D + +++K QQ+ ++ + HE ++ +L D+ KL
Sbjct: 906 TLRE--DLVSEKLKT-----QQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKL-- 956
Query: 1266 DYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQ 1325
++S + ++K +++A ++ + + N L +L + + L Q
Sbjct: 957 -LESKLESTLKKSLEIKE--EKIAALEARLEESTNYNQQLRQELKTVKKNYEA--LKQRQ 1011
Query: 1326 SAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELER 1385
E + S + E ++ ++ E R+ L+ KD I ++ NN L +
Sbjct: 1012 DEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIE-VERNNATL-----------Q 1059
Query: 1386 KEHEQTDSEIKQLKEKQDVLQ-KLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAV 1444
E + +++KQL+ + + LQ ++L + + + +N +V EN L
Sbjct: 1060 AEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQV-ENSTLNSQS 1118
Query: 1445 TNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSM- 1503
T+L + L + L+ ENE +++ ++ Y +L + + K ++ + E S+
Sbjct: 1119 TSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLI 1178
Query: 1504 -----------------KEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER 1546
++ + QLLK+K G+L L +K QEK ++ +
Sbjct: 1179 SKHGTLKSAHKNLEVEHRDLEDRYNQLLKQK-----GQLEDLEKMLKVEQEKMLLENKNH 1233
Query: 1547 DQVMLALKQKQMENTAL---------QNEVQRLRDKEFRSNQELERLRNHLLESEDSYTR 1597
+ V K+ EN L + EV + K +S +L LE+E S +
Sbjct: 1234 ETVAAEYKKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLK 1293
Query: 1598 EALAAED-REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
E D KL + +L + +E + Q+++L Q + +Q E+
Sbjct: 1294 EQYQQLDITSTKLNNQCELLSQ----LKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESK 1349
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAM 1690
V Q +QY L L+ E + EEK M
Sbjct: 1350 DLFHVEQ---RQYIDKLNELRRQKE--KLEEKIM 1378
Score = 156 bits (394), Expect = 2e-37
Identities = 269/1233 (21%), Positives = 523/1233 (42%), Gaps = 198/1233 (16%)
Query: 37 MLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQ---QS 93
+L+E +E +L +R + + +H L EN +LK D+E + + +I++ ++
Sbjct: 355 VLLETKTMLEDQLEGTRARS-DKLHE-LEKENLQLKAKLHDMEMERDMDRKKIEELMEEN 412
Query: 94 TSYRNQLQQKEVEISHL--KARQIALQDQLLK-----LQSAAQSVPSGAGVPATTASSSF 146
+ +Q E HL + QI+ +L + L + S + + S
Sbjct: 413 MTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSL 472
Query: 147 AYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNS 206
+ + + + I+ ++E RLS +V LE+E+ + Q Q
Sbjct: 473 TKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQN--CQNLSKD 530
Query: 207 DQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIE 266
E +L+ I+ L++N ++I + E N H + T S R R ++S E R++
Sbjct: 531 LMKEKAQLEKTIETLRENSERQIKILEQE-----NEHLNQ-TVSSLRQRSQISA-EARVK 583
Query: 267 ELENLLQQGGSGVIETD--LSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSS 324
++E + + ET LSKI + EK + K++E ++K ++
Sbjct: 584 DIEKENKILHESIKETSSKLSKI----------EFEKRQIKKELEHYKEK----GERAEE 629
Query: 325 AENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASV 384
EN+ L +E E L ++ NLK+ C K++ A++Q ++ E+E
Sbjct: 630 LENELHHLEKENELLQ-------KKITNLKITCEKIE--ALEQENSELEREN-------- 672
Query: 385 EEVFRLQQALSDAENEIMRLSSLNQDNS-LAEDNLKLKMRIEVLEKEKSLLSQ---EKEE 440
+L++ L +N +L SL ++NS L E+NL+L+ +E L+ ++Q E +E
Sbjct: 673 ---RKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKE 729
Query: 441 LQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEEL 500
L+ +L E++K++ + L+ L + + ++ L S + + L +E+++L
Sbjct: 730 LESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDL 789
Query: 501 DRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ 560
+ +NQ K++ +K + + +L+++ ++ QLE DK + KE
Sbjct: 790 EMENQTLQKNLEELKISSKR--------LEQLEKENKSLEQETSQLEKDKKQLEKE---- 837
Query: 561 KEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKEN-LELKEHIRQNEEE 619
K ++ + + D L + + K+ NL ++ NK+ + I KE+ + LKE ++N+E
Sbjct: 838 -NKRLRQQAEIKDTTLEENNV--KIGNL-EKENKTLSKEIGIYKESCVRLKELEKENKEL 893
Query: 620 LSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMEN 679
+ R ++ TL+ RE +L + +Q+N +L+K+ ++
Sbjct: 894 VKRATIDI-------------KTLVTLRE----DLVSEKLKTQQMNNDLEKLTHEL---- 932
Query: 680 EKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKY 739
EK+ L E + H +E +++ L ++ + TLK + EI+ E A + LEE+ Y
Sbjct: 933 EKIGLNKERLLH--DEQSTDDSRYKLLESKLESTLK-KSLEIKEEKIAALEARLEESTNY 989
Query: 740 EKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSS- 798
NQ+ E+ +KKN E + E + V SS
Sbjct: 990 ----------------------------NQQLRQELKTVKKNYEALKQRQDEERMVQSSP 1021
Query: 799 ---------SLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALR----KNEILR 845
E Q+ +L+ K+ IE ++ ++ LQ E L+ +N L+
Sbjct: 1022 PISGEDNKWERESQETTRELLKVKDRLIE-VERNNATLQAEKQALKTQLKQLETQNNNLQ 1080
Query: 846 QTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDS-VTELASEVSQLNTI 904
I R S++E+N LQ + +L+ E S TL+S T L ++ +QL
Sbjct: 1081 AQILALQRQTVSLQEQNTTLQTQNAKLQVENS---------TLNSQSTSLMNQNAQLLIQ 1131
Query: 905 KEHLEEEIKHHQKIIED---------QNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHT 955
+ LE E + K ED ++ K++LL + Q E + +H + + H
Sbjct: 1132 QSSLENENESVIKEREDLKSLYDSLIKDHEKLELLH--ERQASEYESLISKHGTLKSAHK 1189
Query: 956 QLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSK 1015
L +E + + ++Q K QL + + ++ + + E K N E + ++
Sbjct: 1190 NLEVEHRDLEDRYNQLLKQ-KGQLEDLEKMLKVEQEKMLLENK----NHETVAAEYKKLC 1244
Query: 1016 AETERLVKGIKE--RELEIKLLNEKNISLTKQIDQLSKD----EVGKLTQIIQQKDLEIQ 1069
E +RL + +E E+ + KN+ +L + E KL + QQ D+
Sbjct: 1245 GENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITST 1304
Query: 1070 ALHARISSTSH-----TQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH--KM 1122
L+ + S ++ +L Q+Q M + + N ++++ H++ + K+
Sbjct: 1305 KLNNQCELLSQLKGNLEEENRHLLDQIQT-LMLQNRTLLEQNMESKDLFHVEQRQYIDKL 1363
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQT 1182
++ KE K+ D+ K S + + ++I+ K +I+ QK T
Sbjct: 1364 NELRRQKEKLEEKIMDQYKFYD---PSPPRRRGNWITLKMRKLIKSKK-DINRERQKSLT 1419
Query: 1183 LLAVLQTSSTG---------NEAGGVNSNQFEE 1206
L SS G ++ V SN E+
Sbjct: 1420 LTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLED 1452
Score = 129 bits (324), Expect = 3e-29
Identities = 250/1255 (19%), Positives = 509/1255 (40%), Gaps = 195/1255 (15%)
Query: 669 KKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIV-ETLKMEKGEIEAELCW 727
KKV D + L + ++ +E L +SL I+ + E+G E
Sbjct: 66 KKVNNDASLRMHNLSILVRQIKFYYQETLQQLIMMSLPNVLIIGKNPFSEQGTEEV---- 121
Query: 728 AKKRLL------EEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKD-----MEIA 776
KK LL + K E+ IE + + +T A H + NQ+ ME+
Sbjct: 122 -KKLLLLLLGCAVQCQKKEEFIERIQGL-DFDTKAAVAAHIQEVTHNQENVFDLQWMEVT 179
Query: 777 E----------------LKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKL 820
+ LK+ I++ D +H ET LS + L + +
Sbjct: 180 DMSQEDIEPLLKNMALHLKRLIDERD-EHSETIIELSEERDGLHFLPHASSSAQSPCGSP 238
Query: 821 KERSSKLQEELD-KYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRT 879
+ ++ ++ L + + A K LRQ +EEK L K+E ++ EL+RL++E
Sbjct: 239 GMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQMEIELKRLQQENMNL 298
Query: 880 APVADPKT-------LDSVTELASEV----SQLNTIKEHLE---------EEIKHHQKII 919
++D ++ LD++ E A V S+++ KE L EE+K +++
Sbjct: 299 --LSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYKARVEELKEDNQVL 356
Query: 920 EDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQL 979
+ L+ + + ++ E ++ Q+ A + +E+D + K ++ +L
Sbjct: 357 LETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIE--------EL 408
Query: 980 HEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKE-RELEIKLLNEK 1038
EE ++ E+ +E S +LS+A + L + E + L +
Sbjct: 409 MEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSSRLLKLEME 468
Query: 1039 NISLTKQIDQL---------SKDEVGKLTQIIQQKDLEIQALHARISSTSHT-QDVVYLQ 1088
N SLTK +++L + ++ K+ + Q+ +++ L I + Q+ L
Sbjct: 469 NQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLS 528
Query: 1089 QQLQAYAMEREKVFAVLNEKT--------RENSHLKTEYHKMMDIVAAKEAALIK-LQDE 1139
+ L + EK L E + +EN HL + A +K ++ E
Sbjct: 529 KDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKE 588
Query: 1140 NKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGV 1199
NK L + +ET LS+I EK + + L+ E
Sbjct: 589 NKIL--------HESIKETSSKLSKIEFEK-----------RQIKKELEHYKEKGERAEE 629
Query: 1200 NSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDN 1259
N+ L +E + L++++ ++ +++ + ++ E+++L+ E +L+ + DS
Sbjct: 630 LENELHHLEKENELLQKKITNLKITCEKI----EALEQENSELERENRKLKKTL--DSFK 683
Query: 1260 NSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSA 1319
N Q ++S E+ ++L EL + S+ + + +L + + +L S
Sbjct: 684 NLTFQ------LESLEKENSQLDEENLELRRNVESL----KCASMKMAQLQLENKELESE 733
Query: 1320 SLLTPQSAECLRAS--KSEVLSES-------SELLQQELEELRKSLQEKDATIR------ 1364
+ E L+AS K+E L S ++ LQ+ LE K +Q+ ++ ++
Sbjct: 734 KEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQDLEMEN 793
Query: 1365 -TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
TLQ+N L S +LE KE++ + E QL++ + L+K K + K L
Sbjct: 794 QTLQKNLEELKISSKRLEQLE-KENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTL 852
Query: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVET----YRGKETEY 1479
+N N EN+ L + + KE + L+ +L+ EN+++V+ + T
Sbjct: 853 EENNVKIGNLEKENKTLSKEIGIYKESCVRLK----ELEKENKELVKRATIDIKTLVTLR 908
Query: 1480 QALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKT 1539
+ L +K M + E H +++ L E+LL +++ L + ++S +K+
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKS 968
Query: 1540 VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREA 1599
+ ++E+ +A + ++E + N+ R K + N E + R
Sbjct: 969 LEIKEEK----IAALEARLEESTNYNQQLRQELKTVKKNYEALKQR-------------- 1010
Query: 1600 LAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQL 1659
+D E ++ + E N E S + + ++ ++++L V + +
Sbjct: 1011 ---QDEERMVQSSPPISGE-----DNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062
Query: 1660 SVSQEQVKQYALSLANLQMVLEHFQQEEKAM---------YSAELEKQKQLIAEWKKNAE 1710
+ Q+KQ NLQ + Q++ ++ +A+L+ + + +
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMS 1770
N +++ Q L+ N ++ + E+ D+K +K +L E+L + Q
Sbjct: 1123 NQNAQLLIQQSSLENENESV-----IKEREDLKSLYDSLIKDHEKL--ELLHERQASEYE 1175
Query: 1771 LANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHDDQ 1825
S G + K +NL + H +++ +++L+ G + E++E++ +Q
Sbjct: 1176 SLISKHGTL-KSAHKNLEVEH-RDLEDRYNQLLKQKGQL-----EDLEKMLKVEQ 1223
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 179 bits (453), Expect = 3e-44
Identities = 350/1771 (19%), Positives = 727/1771 (41%), Gaps = 190/1771 (10%)
Query: 101 QQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDD 160
+QK++E K Q + K QS QS T+SS H SA HD
Sbjct: 6 RQKKLEAGKAKLAQFRQR----KAQSDGQSPSKKQKKKRKTSSSK------HDVSAHHDL 55
Query: 161 DMDFGDIISSQQEINRLS-NEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIK 219
++D Q + N + N R+ES V I +T + + +Q +L++ I
Sbjct: 56 NID-------QSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEIS 108
Query: 220 ELKQNRSQEIDDHQHEMSVLQ--NAHQQKLTEISRRHREE-LSDYEERIEELENLLQQGG 276
+ S E++ M + N +++ + + E+ D +E +E+ L G
Sbjct: 109 TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELA-GK 167
Query: 277 SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQ 336
IE ++ EM+ T E +++++ E IK + ++ + RRE+
Sbjct: 168 QHEIEELNRELEEMRVTYGT------EGLQQLQEFEAAIKQRDGIITQLTANLQQARREK 221
Query: 337 EQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSD 396
++ E ++ E+ + L+++ +LQ S ++ T + L Q+ +++ QQ L +
Sbjct: 222 DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK--QQILTHQQQLEE 279
Query: 397 AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK 456
++ + +D ++ L+ K+++ +E++K + + KEE+Q E E I
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ--------EKETII 331
Query: 457 STATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKD 516
EL+ + E K EL ++ + L+ E++E Q + K+M L
Sbjct: 332 E----------ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
Query: 517 QLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKE-KLIQSEVALNDLH 575
+++ + I +L + + +KR H+ + DI + ++ + + KL Q L++++
Sbjct: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
Query: 576 LTK--QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLN- 632
+ Q ++ + + Q+ + + + + L +I NE+++ ++ N + LN
Sbjct: 442 GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNI 500
Query: 633 --QDSNSN---FKDTL---LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL-- 682
QD+NS K+ L L+E+ A R L+ + EL E +++ + + KL
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 683 ----VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEE-AN 737
+ ED++ ++ +L L+ V K++ +E E K +L+ A
Sbjct: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE----KNAVLDRMAE 616
Query: 738 KYEKTIEEL------SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791
E +E L S+ L+ LE EH I + + KD K+ I+ + + +
Sbjct: 617 SQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ 676
Query: 792 TKDVLS----SSLEEQKQLTQLINKKEIFIEKL---KERSSKLQ-EELDKYSQALRKNEI 843
+ + + + +Q QL I+K + + L K LQ EL K + LR+ E
Sbjct: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK 736
Query: 844 LRQTIEEKDRSLG--------SMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELA 895
+ T+E++ + L MKE+ N LQE+ +L E S + KTL+ + ++
Sbjct: 737 EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIH 794
Query: 896 SEVSQ------LNTIKEHLEEEI--KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947
+ VSQ L++IK ++ + K + +IE+ K Q +Q +E +K+ + F +
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENG 1007
+ + +L EE L K + ++ +++ + ++ + +E +Q +N
Sbjct: 855 KNFEVNYQEL----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910
Query: 1008 SEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLE 1067
K + + K LE+ + EK+ + + +++K E +L+Q + +
Sbjct: 911 KMKSSVFDED-----KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ 965
Query: 1068 IQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN-SHLKTEYHKMMDIV 1126
++ H IS + ++V L+Q+ + ++ ++ ++N EN T+ ++D V
Sbjct: 966 LKQKHGEISFLN--EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGV 1023
Query: 1127 AAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186
+ + K++ F + M + + + + E+ S++ Q +L
Sbjct: 1024 VTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE-------SKQEQLILDH 1074
Query: 1187 LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246
L + + + ++ ++L +E + LK + Q + Q L
Sbjct: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSE--------QNDLRLQMEAQRICLSLVYST 1126
Query: 1247 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS--IGQLCNTKDL 1304
H Q + ++++ + L LI + E+ +L+ Q Q + G L
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Query: 1305 LLGKLDIISPQLSSASLLTPQSA---ECLRASKSEVLSESSELLQQELEELRK-SLQEKD 1360
L+GKL + S L T S A K EV +E E + E LQ+
Sbjct: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
Query: 1361 ATIRTLQENNHRLSDSIAAT--------SELERKEHEQTDSEIKQLKEKQDVLQKLLKEK 1412
++ QEN H L + + + L + +QTD + E + L KE+
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-----ENLPKEE 1301
Query: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472
+ S + + +K + L T L+E++ LE I L+ + ++ + Y
Sbjct: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
Query: 1473 RGK----ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK---TGE- 1524
+ + QA+ E+ + S+ + + S ++ + +K+ G +GE
Sbjct: 1362 EAEIHCLQKRLQAVSESTVPPSLPV-DSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEF 1420
Query: 1525 -LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELER 1583
+ + N VK ++++ +Q++ ++ + + A Q E+ R+ + N +
Sbjct: 1421 GVKEETNIVKLLEKQ---YQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTASSK 1475
Query: 1584 LRNHLLESEDSYTREALAAEDR---------EAKLRKKVTVLEEKL------VSSSNAME 1628
+ + + E Y E ++D+ + K +++ L ++L + SN+
Sbjct: 1476 QAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP 1535
Query: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMV----LEHFQ 1684
+ ++ V ++ E++ +D+T + +++ ++ + M+ LE +
Sbjct: 1536 HDIPESKDCVLTISEEMF----SKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591
Query: 1685 QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKE 1744
QE Y + + L + E LQE + N L S + + V E
Sbjct: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE 1651
Query: 1745 EQIEELKRQNELRQEMLDDVQKKLMSLANSS 1775
+ L+ L+Q L +K L NSS
Sbjct: 1652 RERVLLEELEALKQLSLAGREKLCCELRNSS 1682
Score = 170 bits (431), Expect = 1e-41
Identities = 362/1741 (20%), Positives = 730/1741 (41%), Gaps = 263/1741 (15%)
Query: 202 GTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAH--QQKLTEISRRHREELS 259
GT+ ++E L NI L+ + ++ S L++A Q +L S R ++E +
Sbjct: 1832 GTEIDPENEELML-NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT 1890
Query: 260 DYEERIEELENLLQQGGSG--VIETDLSKI------YEMQKTIQVLQI-EKVESTKKMEQ 310
+ + EEL L + + +LSK Y +KT+ QI EK + ++EQ
Sbjct: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950
Query: 311 ----LEDKIKDINKKLSSAENDRDILRREQEQLNVE----KRQIMEECENLKLECSKLQP 362
++++++ + + +R++L R++E + E ++Q+++E E L E ++Q
Sbjct: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010
Query: 363 SAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM 422
A K D + ++ + L E+V R + + E+M L NQ + ++ +
Sbjct: 2011 QAEKVRDDLQKQVKALEIDVE-EQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFL 2069
Query: 423 RIEVLEKE--KSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISL-----------DSEL 469
+ +++E + + QE ++L+ L K+ ++ I TR++ SEL
Sbjct: 2070 DEQAIDREHERDVFQQEIQKLEQQL-KVVPRFQPISEHQTREVEQLANHLKEKTDKCSEL 2128
Query: 470 HDLRLNLEAKEQELNQSISEKETLIAEIEEL------DRQNQEATKHM--ILIKDQLSKQ 521
+ L+ QE N+ I + E + E+E+ Q E KH + K +LS +
Sbjct: 2129 LLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLE 2188
Query: 522 ---QNEGDSI------ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALN 572
Q E D+I I+ L++ L ++ + ++ + +L++QK+ +S L
Sbjct: 2189 VQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK---ESTTRLQ 2245
Query: 573 DLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENL---ELKEHIRQNEEELSRIRNELMQ 629
+L + +D +E L + +S +S Q +++ + + I++ E E+ ++ NE +
Sbjct: 2246 ELEQENKLFKDDMEKLGLAIKESDA--MSTQDQHVLFGKFAQIIQEKEVEIDQL-NEQVT 2302
Query: 630 SLNQDSNSNFKDTLLKEREAEVRNLKQNLS---------------ELEQLNENLKKVAFD 674
L Q + +++E+ +R+L+ + E+EQLNE ++K+ +
Sbjct: 2303 KLQQQLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQE 2362
Query: 675 V-------KMENEKLVLACEDVRHQLEECLA-----------GNNQLSLEKNTIVETLKM 716
+ M L + ++HQL+ +A N +++ KN + ET
Sbjct: 2363 LANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET-NF 2421
Query: 717 EKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIA 776
+ ++ EL ++ KR E K + E N + S + E E ++ + K +E
Sbjct: 2422 KMNQLTQEL-FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQ 2480
Query: 777 ELKKNIEQ--------MDTDHKETKDVLSSSLEE----QKQLTQLINKKEIFIEKLKERS 824
K+ E+ ++T + + +S+ E KQ+ + + + E L+++
Sbjct: 2481 TYFKSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKI 2540
Query: 825 SKLQEELDKYSQALRKNEILRQTIEE-----KDRSLGSMKEENNHLQEELERLREEQSRT 879
LQ+ +++ A ++I + ++E +D S + E ++Q L +LRE++ +
Sbjct: 2541 VNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-LNQLREDELGS 2599
Query: 880 APVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKE 939
A TL ++EL S+V +++T +E+++ +K + ++ + ++L + L+ +K+
Sbjct: 2600 DISA--LTL-RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKK 2656
Query: 940 MDEFRYQHEQMNA----THTQLFLEKDE-----EIKSLQKTIEQIKTQLHEERQDIQTDN 990
E + + T T+LF +E E+++L+ K +L ++ +
Sbjct: 2657 QREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQ 2716
Query: 991 SDIF-QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQID-Q 1048
++ +ET + SL + + L++A+ E+L I E+E E ++ K + + + +
Sbjct: 2717 EELLVKETNMTSLQKDLSQVRDHLAEAK-EKL--SILEKEDETEVQESKKACMFEPLPIK 2773
Query: 1049 LSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEK 1108
LSK I Q D + +ISS++ T ++ +Q E
Sbjct: 2774 LSKS-------IASQTDGTL-----KISSSNQTPQILVKNAGIQINLQSE----CSSEEV 2817
Query: 1109 TRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIRE 1168
T S + KM ++ AA+ DM I + RE
Sbjct: 2818 TEIISQFTEKIEKMQELHAAEIL---------------------DMESRHISETETLKRE 2856
Query: 1169 KDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQV 1228
+ + L ++C TL AV+Q + E + + Q R+ +W Q +
Sbjct: 2857 HYVAVQLLKEECGTLKAVIQCLRS-KEGSSIPELAHSDAYQTREICSSD--SGSDWGQGI 2913
Query: 1229 MTT-------VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS-YEQNETK 1280
T + E ++ + + + L+ + +N +QV L +S Y E
Sbjct: 2914 YLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV--LSLTESPYSDGEDH 2971
Query: 1281 LKNFGQE--LAQVQHSIGQLCNTKDLL----LGKLDIISPQLSSASLLTPQSAECLRASK 1334
E L + + I + + KDL+ L + + S + E L A +
Sbjct: 2972 SIQQVSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQ 3031
Query: 1335 SEVLSESSELLQQELEELRKSLQEKDAT--IRTLQENNHRLSDSIAATSE-LERKEHEQT 1391
L E S LL EL +L DA + L++ A E L++ +
Sbjct: 3032 QVFLEERSVLLAAFRTELT-ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSL 3090
Query: 1392 DSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENEL----LRQAVTNL 1447
SEI+ L + + + LK + K + L + + +++ E ++ ++ T L
Sbjct: 3091 LSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATEL 3150
Query: 1448 KERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMK----FSMMLREKEFECHSM 1503
+E++ +M + +LK E + +T ET +A Q ++K F + +++K E H +
Sbjct: 3151 QEQLSSEKMVVAELKSE---LAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEVHLL 3206
Query: 1504 KEKALAFEQLLK-------EKEQGKTG--------ELNQLLNAVKSMQEKTVVFQQERDQ 1548
+ LA EQ EKE+ K G EL L +++S +++ +
Sbjct: 3207 ND-TLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLN----- 3260
Query: 1549 VMLALKQKQMENTALQN-EVQR-LRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE 1606
+L +QKQ+ N + Q E QR L D + Q LLESE RE + DRE
Sbjct: 3261 -LLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRE 3319
Query: 1607 AKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQV 1666
+L + L SS ++ S ++ L + KQ +E ++ +
Sbjct: 3320 RELHAQ-------LQSSDGTGQSRPPLPS------EDLLKELQKQLEEKHSRIVELLNET 3366
Query: 1667 KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEA 1726
++Y L + +E +++ ++ L+ +++ E +K L+ KV LQ
Sbjct: 3367 EKYKLDSLQTRQQME----KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR----- 3417
Query: 1727 NAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRN 1786
QL+ K +Q+ +L + + Q ++ + QK+ + E + ++L +N
Sbjct: 3418 ------------QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESR--RILYQN 3463
Query: 1787 L 1787
L
Sbjct: 3464 L 3464
Score = 170 bits (430), Expect = 1e-41
Identities = 357/1701 (20%), Positives = 703/1701 (41%), Gaps = 260/1701 (15%)
Query: 40 EGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQ 99
E TE + + ++I+ H S + L+K T LEE+ + E I +
Sbjct: 1300 EETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK--TKLEEQVQELESLISSLQQQLKET 1357
Query: 100 LQQKEVEISHLKARQIALQDQLLKLQSAAQS-VPSGAGVPATTASSSFAYGISHHPSAFH 158
Q E EI L+ R LQ+ ++S VP V + + S A + +P +
Sbjct: 1358 EQNYEAEIHCLQKR----------LQAVSESTVPPSLPVDSVVITESDAQR-TMYPGSCV 1406
Query: 159 DDDMDFGDIISSQQEINRLSNEVSRLESEVGHW--RHIAQTSKAQGTDNSDQSEICKLQN 216
++D S + + +N V LE + +A+ + + Q+E+ ++
Sbjct: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
Query: 217 IIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTE--ISRRHREELS-DYEERIEELENLLQ 273
K+N + H ++ KL++ I + E + ++E + L L
Sbjct: 1467 G----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG 1522
Query: 274 QGGSGVI--ETDLSKIYEMQKTIQVLQIEKVESTKKM---EQLEDKIKDINKKLSSAEND 328
+ G ++ +D I E + + + E K + + D+I +SS +
Sbjct: 1523 EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS-----VSSMDAS 1577
Query: 329 RDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVF 388
R ++ E EQL +++++ + + + L+ + ++Q + E + L EE+
Sbjct: 1578 RQLMLNE-EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ-----EEIK 1631
Query: 389 RLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKE--ELQMSLL 446
RL + L+ SS++ +N ++E L +E L K+ SL +EK EL+ S
Sbjct: 1632 RLNRQLAQR-------SSIDNENLVSERERVLLEELEAL-KQLSLAGREKLCCELRNSST 1683
Query: 447 KLNNEYE---VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEK--ETLIAEIEELD 501
+ N E ++ ++ LD + D+ + + E+ Q + + + L+ ++
Sbjct: 1684 QTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743
Query: 502 RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK 561
+ +H++ I D+ SK Q+ S+I + + + + K VH+ + T+ D
Sbjct: 1744 AVEETIGRHVLGILDRSSKSQSSA-SLIWRSEAEAS-VKSCVHE------EHTRVTDESI 1795
Query: 562 EKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621
S++ ND+++ + E+ E L +L +S + I EN EL +I L
Sbjct: 1796 PSYSGSDMPRNDINMWSKVTEEGTE-LSQRLVRSGFAGTEIDPENEELMLNI---SSRLQ 1851
Query: 622 RIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEK 681
+L++++++ S+ L + L + +F K E +
Sbjct: 1852 AAVEKLLEAISETSSQ--------------------LEHAKVTQTELMRESFRQKQEATE 1891
Query: 682 LVLACEDVRHQLEECLAGNNQLSLE-------------KNTIVETLKMEKGEI----EAE 724
+ E++R +L E QL++E + T+ E EK +I E E
Sbjct: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQE 1951
Query: 725 LCWAKKRLLE---EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
L A RL E E + ++ E LS + + + L++ +K E E++
Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Query: 782 IEQMDTDHKETKDVLSSSLEEQ-KQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
E++ D ++ L +EEQ + +L +K + L++++ L+++L+K + L +
Sbjct: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
Query: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS---RTAPVADPKTLDSVTELASE 897
I R+ E + Q+E+++L ++ R P+++ +T + V +LA+
Sbjct: 2072 QAIDRE-------------HERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE-VEQLANH 2117
Query: 898 V-------SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQ---------EQKKEMD 941
+ S+L KE L+ +I+ + IE +L Q+L E +K
Sbjct: 2118 LKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFG 2177
Query: 942 EFRYQHEQMNATHTQLFLEKD------EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQ 995
+ E + QL E+D +EI +L++ +EQ + +L + +++Q + +
Sbjct: 2178 AVEAKPEL--SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEI 2235
Query: 996 ETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG 1055
+ K + ++ +++ L K + E+L IKE + +++ Q + G
Sbjct: 2236 QKKESTTRLQELEQENKLFKDDMEKLGLAIKESD-----------AMSTQDQHVL---FG 2281
Query: 1056 KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHL 1115
K QIIQ+K++EI L+ + V LQQQL+ + V+ EK L
Sbjct: 2282 KFAQIIQEKEVEIDQLN---------EQVTKLQQQLKITTDNK-----VIEEKNELIRDL 2327
Query: 1116 KTEYHKMMD----IVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDI 1171
+T+ +M + +E + +L + +KL + GQ +T N + E D
Sbjct: 2328 ETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANIGQ----KTSMNAHSLSEEADS 2383
Query: 1172 EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTT 1231
L LA+ Q T N EE+ ++ LK+ KM + Q++ +
Sbjct: 2384 LKHQLDVVIAEKLALEQQVETAN----------EEMTFMKNVLKETNFKMNQLTQELFSL 2433
Query: 1232 VQNMQHESAQLQEELHQLQAQVLVD--SDNNSKLQVDYTGLIQSYEQNETKLKNFGQELA 1289
+ ES + + + + V +D S + +L+V T +N+T K+F
Sbjct: 2434 --KRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF----- 2486
Query: 1290 QVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASK--SEVLSESSELLQQ 1347
++ G + N + LL +L+ S+ S + +C + K E +E+LQ+
Sbjct: 2487 -EENGKGSIINLETRLL-QLE------STVSAKDLELTQCYKQIKDMQEQGQFETEMLQK 2538
Query: 1348 ELEELRKSLQEKDAT-------IRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKE 1400
++ L+K ++EK A + +QE D+ +SE ER + + QL+E
Sbjct: 2539 KIVNLQKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ----NLNQLRE 2594
Query: 1401 KQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGK 1460
D L + L I Q++ E T+ + E E + A N+ E+ L +++ K
Sbjct: 2595 --DELGSDISALTLRISELESQVV---EMHTSLILEKEQVEIAEKNVLEKEKKL-LELQK 2648
Query: 1461 LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQG 1520
L NEK K+ E +EK+ ++ E +E G
Sbjct: 2649 LLEGNEK-------KQRE---------------KEKKRSPQDVEVLKTTTELFHSNEESG 2686
Query: 1521 KTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQE 1580
EL L + + + ++++ +++ L K+ T+LQ ++ ++RD + ++
Sbjct: 2687 FFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEK 2746
Query: 1581 LERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKL--VSSSN-----AMENASHQ 1633
L L E+E +++A E KL K + + +SSSN ++NA Q
Sbjct: 2747 LSILEKE-DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQ 2805
Query: 1634 ASVQVESLQEQLNVVSKQRDE 1654
++Q E E++ + Q E
Sbjct: 2806 INLQSECSSEEVTEIISQFTE 2826
Score = 165 bits (417), Expect = 5e-40
Identities = 368/1902 (19%), Positives = 775/1902 (40%), Gaps = 307/1902 (16%)
Query: 29 QISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENER---LKKLCTDLEEKHEAS 85
++ + + ++ +EE+ ++ + + KEIE ILR E + L++ +L+ K E
Sbjct: 701 KLKDLQQSLVNSKSEEMTLQINELQ-KEIE----ILRQEEKEKGTLEQEVQELQLKTELL 755
Query: 86 EIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSS 145
E Q+K++ + + Q E E S LK + L+D +LK+ + + + + S
Sbjct: 756 EKQMKEKENDLQEKFAQLEAENSILKDEKKTLED-MLKIHTPVSQEERLIFLDSIKSKSK 814
Query: 146 FAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDN 205
D + +I +E L + +L E+ R+ ++ N
Sbjct: 815 --------------DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 206 SD--QSEICKLQNIIKELKQNRSQEIDDHQHEMSVL-QNAHQQKLTEISRRHREELSDYE 262
Q E L + +L+ +++++ +++ ++ L + H Q++ + + + + D +
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Query: 263 ERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKME-QLEDKIKDINKK 321
+ + L+ G V+E D +++ +EK+E TK+ + +L ++ D++++
Sbjct: 921 KTF--VAETLEMG--EVVEKDTTEL-----------MEKLEVTKREKLELSQRLSDLSEQ 965
Query: 322 LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEK--ERILA 379
L + L E + L EK Q+ C L++ + + V+ DT + ++
Sbjct: 966 LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
Query: 380 QSASVEE--VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM----RIEVLEKEKSL 433
++ E V ++ ++ + E++IM ++ +N + K + + + KE SL
Sbjct: 1026 MTSRGAEGSVSKVNKSFGE-ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084
Query: 434 LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETL 493
+ + E KL E V+K SE +DLRL +EA+ L+ S
Sbjct: 1085 RATQPSEND----KLQKELNVLK----------SEQNDLRLQMEAQRICLSLVYSTHVDQ 1130
Query: 494 IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL---------KQDLNDEKKRVH 544
+ E E E K + +K++L Q E + K+ Q+ DE K +H
Sbjct: 1131 VREYME-----NEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185
Query: 545 QLEDDKMDITKELDVQKEKLIQSEVALNDLHLT-----KQKLEDKVENLVDQLNKSQESN 599
L + K + + +Q+ ++ + T + EDK EN D ++++++
Sbjct: 1186 LLIG---KLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYISENEDPE 1241
Query: 600 V--------SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNS---NFKDTLLKERE 648
+ Q+ L + + +L ++ L + Q ++ F + L + E
Sbjct: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
Query: 649 AEVRNLKQNLSELEQLNENLK-KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK 707
E ++ ++ LE ++ N K K++ +E KL E+ +LE +
Sbjct: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL----EEQVQELESLI---------- 1347
Query: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKY--------EKTIEELSNARNLNTSALQL 759
+++ + LK + EAE+ +KRL + I E R + +
Sbjct: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407
Query: 760 EH-----EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSL--EEQKQLTQLINK 812
++ E + K++ I +L + Q + + K ++S S+ +Q +L+++
Sbjct: 1408 KNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG 1467
Query: 813 KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL 872
KE + + QE+ L +++I QT E D KEE L +EL
Sbjct: 1468 KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD---VKFKEEFKPLSKELGEH 1524
Query: 873 REE--QSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930
+E S + P P++ D V ++ E+ + K + + H + + + S+ +L
Sbjct: 1525 GKEILLSNSDPHDIPESKDCVLTISEEM--FSKDKTFIVRQSIHDEISVSSMDASRQLML 1582
Query: 931 --QSLQEQKKEMDEFRYQHEQ----MNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQ 984
+ L++ ++E+ +H+Q + H + + E+ + LQ+ I+++ QL +R
Sbjct: 1583 NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL-AQRS 1641
Query: 985 DIQTDN------------------------SDIFQETKVQSLNIENGSEKHDLSKAETER 1020
I +N + E + S +NG+E + +T
Sbjct: 1642 SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT-- 1699
Query: 1021 LVKGIKERELEIK-------LLNEKNISLTKQIDQLSKD--EVGKLTQIIQQK-DLEIQA 1070
KE+EL+ K +L+ + +L K ++L K EV K T +++ +
Sbjct: 1700 ----FKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLG 1755
Query: 1071 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKE 1130
+ R S + + +++ + E V E TR Y D+
Sbjct: 1756 ILDRSSKSQSSASLIWRSE------AEASVKSCVHEEHTRVTDESIPSY-SGSDMPRNDI 1808
Query: 1131 AALIKLQDENKKLSTRFESS---GQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVL 1187
K+ +E +LS R S G ++ E + + I ++ L L A+
Sbjct: 1809 NMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL------LEAIS 1862
Query: 1188 QTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELH 1247
+TSS A + E +++ + + +K EE ++++ HE ++ +E+L
Sbjct: 1863 ETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL--------HEESRAREQL- 1913
Query: 1248 QLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLG 1307
+ SK + G+I Y +T + QE + + Q L
Sbjct: 1914 ---------AVELSKAE----GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ 1960
Query: 1308 KLDIISPQLSSASLLTPQSAECLRAS----KSEVLSESSELLQQELEELRKSLQEKDATI 1363
+L+ Q+ L + E ++A + ++L E+ +L++++LE ++ + +D
Sbjct: 1961 ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ 2020
Query: 1364 RTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
+ ++ + + ++ ELE ++ ++E+ L+++ L+K L++ +
Sbjct: 2021 KQVKALEIDVEEQVSRFIELE----QEKNTELMDLRQQNQALEKQLEKMRKFL------- 2069
Query: 1424 LSSNENFTNKVNENELLRQAVTNLKERILI--------------LEMDIGKLKGENEKIV 1469
+E ++ +E ++ +Q + L++++ + +E LK + +K
Sbjct: 2070 ---DEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDKCS 2126
Query: 1470 ETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLL 1529
E KE + +QE N + + + EF +++ L ++ E K
Sbjct: 2127 ELLLSKEQLQRDIQERNEE----IEKLEFRVRELEQALLVSADTFQKVEDRKH------F 2176
Query: 1530 NAVKSMQEKT--VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNH 1587
AV++ E + V Q ERD A+ +K+ E T L+ ++++ R++ N+E+++L
Sbjct: 2177 GAVEAKPELSLEVQLQAERD----AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQ 2232
Query: 1588 L-------------LESE-----DSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMEN 1629
L LE E D + LA ++ +A + VL K E
Sbjct: 2233 LEIQKKESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEV 2292
Query: 1630 ASHQASVQVESLQEQL-----NVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ 1684
Q + QV LQ+QL N V ++++E L E L + Q ++ +
Sbjct: 2293 EIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIE-------CLMSDQECVKRNR 2345
Query: 1685 QEEKAMYSAELEKQKQLIA----EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQL 1740
+EE + +EK +Q +A + NA +L + SL+ LD + L +Q+
Sbjct: 2346 EEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLD---VVIAEKLALEQQV 2402
Query: 1741 DVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
+ E++ +K + ++ + ++L SL E V+K+
Sbjct: 2403 ETANEEMTFMKNVLKETNFKMNQLTQELFSLKRERE-SVEKI 2443
Score = 154 bits (389), Expect = 8e-37
Identities = 318/1649 (19%), Positives = 674/1649 (40%), Gaps = 254/1649 (15%)
Query: 254 HREELSDYEERIEELENLLQQGGSG--VIETDLSKIYEMQKTIQVLQIEKVESTKKMEQL 311
+R E+ D++E + L N + + + V++T LSKI+ Q L+ + K+
Sbjct: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKE---- 1300
Query: 312 EDKIKDINKKLSSAENDRDILRREQ--EQLNVEKRQIMEECENLKLECSKLQPSAVKQSD 369
E + I+ ++++ E D D+ + + ++EK ++ E+ + L+ S LQ +K+++
Sbjct: 1301 ETEFLSIHSQMTNLE-DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ-LKETE 1358
Query: 370 TMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLK----LKMRIE 425
E E Q RLQ + + S+ S A+ + +K I+
Sbjct: 1359 QNYEAEIHCLQK-------RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID 1411
Query: 426 VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQ 485
+ ++E + LL+ + ++ + A +S+ A++ EL++
Sbjct: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAF--------AQQTELSR 1463
Query: 486 SISEKETLIA--EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISK-----LKQDLND 538
KE + + + +Q Q M L +DQ+ Q E + K L ++L +
Sbjct: 1464 ISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE 1523
Query: 539 EKKRVHQLEDDKMDITKELD---------------------VQKEKLIQSEVALNDLHLT 577
K + D DI + D + E + S A L L
Sbjct: 1524 HGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLN 1583
Query: 578 KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNS 637
+++LED + LV Q + Q++ +++ ++ E R+++E+L L + L Q S+
Sbjct: 1584 EEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSI 1643
Query: 638 NFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
+ + L+ ERE R L + L L+QL+ EKL C ++R+ +
Sbjct: 1644 D-NENLVSERE---RVLLEELEALKQLS----------LAGREKL---CCELRNSSTQTQ 1686
Query: 698 AGN-NQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEAN-----------KYEKTIE 744
GN NQ +E+ T E L + ++ E+ ++ L++AN K +E
Sbjct: 1687 NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVE 1746
Query: 745 ELSNARNLN---------------------TSALQLEHEHLIKLNQKK--DMEIAELKKN 781
E L S HE ++ + +++ +N
Sbjct: 1747 ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN 1806
Query: 782 IEQMDTDHKETKDVLSSSL------------EEQKQLTQLINKKEIFIEKLKERSSKLQE 829
M + E LS L E ++ + + ++ + +EKL E S+
Sbjct: 1807 DINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSS 1866
Query: 830 ELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLD 889
+L+ + + E++R++ +K + S+K QEEL E+SR
Sbjct: 1867 QLEHAK--VTQTELMRESFRQKQEATESLK-----CQEELRERLHEESRARE-------- 1911
Query: 890 SVTELASEVSQLNTI-------KEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 942
+LA E+S+ + K E +I+ II+ Q + LQE + E +
Sbjct: 1912 ---QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
Query: 943 FRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSL 1002
+ + E ++ + E + L + E++ + E + + D+ ++ K +
Sbjct: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI 2028
Query: 1003 NIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQ 1062
++E + R ++ +E+ E+ L ++N +L KQ++++
Sbjct: 2029 DVEE----------QVSRFIELEQEKNTELMDLRQQNQALEKQLEKM------------- 2065
Query: 1063 QKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRE----NSHLKTE 1118
+K L+ QA+ Q++ L+QQL+ + + +TRE +HLK +
Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP----RFQPISEHQTREVEQLANHLKEK 2121
Query: 1119 YHKMMDIVAAKEAALIKLQDENK---KLSTRFESSGQ------DMFR--ETIQNLSRIIR 1167
K +++ +KE +Q+ N+ KL R Q D F+ E ++ +
Sbjct: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEA 2181
Query: 1168 EKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVK-KMEEWKQ 1226
+ ++ ++ Q + + + T E QF E L+ +++ QQ+ ++E K+
Sbjct: 2182 KPELSLEVQLQAERDAIDRKEKEITNLEE---QLEQFREELENKNEEVQQLHMQLEIQKK 2238
Query: 1227 QVMTTVQNMQHESAQLQEELHQLQAQVLV-DSDNNSKLQVDYTGLIQSYEQNETKLKNFG 1285
+ T +Q ++ E+ ++++ +L + D+ + V + Q ++ E ++
Sbjct: 2239 ESTTRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLN 2298
Query: 1286 QELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELL 1345
+++ ++Q + ++ ++ K ++I + L EC++ ++ E + + +E++
Sbjct: 2299 EQVTKLQQQL-KITTDNKVIEEKNELIRDLETQIECLMSDQ-ECVKRNREEEIEQLNEVI 2356
Query: 1346 QQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL 1405
++ +EL Q+ +L E +DS+ ++ E + +++ E+ +
Sbjct: 2357 EKLQQELANIGQKTSMNAHSLSEE----ADSLKHQLDVVIAEKLALEQQVETANEEMTFM 2412
Query: 1406 QKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMD-IGKLKGE 1464
+ +LKE + + + +L S E E + + + ++ E + + +D + K K E
Sbjct: 2413 KNVLKETNFKMNQLTQELFSLKR-------ERESVEK-IQSIPENSVNVAIDHLSKDKPE 2464
Query: 1465 NEKIVETYRGKETEYQALQ---ETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK 1521
E ++ K E Q E N K S++ +++ + L E + K+
Sbjct: 2465 LEVVLTEDALKSLENQTYFKSFEENGKGSII---------NLETRLLQLESTVSAKDL-- 2513
Query: 1522 TGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQEL 1581
EL Q +K MQE+ Q + QK++ N LQ V+ S +L
Sbjct: 2514 --ELTQCYKQIKDMQEQ--------GQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQL 2561
Query: 1582 ERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESL 1641
E ++ + +D+ T +++E ++ + E++L S +A+ + QV +
Sbjct: 2562 EAVQEYAKFCQDNQT---ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEM 2618
Query: 1642 QEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ----QEEKAMYSAELEK 1697
L ++ K+ Q+ ++++ V + L LQ +LE + ++EK ++E
Sbjct: 2619 HTSL-ILEKE------QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEV 2671
Query: 1698 QKQLIAEWKKNAEN---LEGKVISLQECLDEANAAL--DSASRLTEQLDVKEEQIEELKR 1752
K + N E+ E + + + +A A + A +L E+L VKE + L++
Sbjct: 2672 LKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQK 2731
Query: 1753 QNELRQEMLDDVQKKLMSLANSSEGKVDK 1781
++ L + ++KL L E +V +
Sbjct: 2732 DLSQVRDHLAEAKEKLSILEKEDETEVQE 2760
Score = 124 bits (312), Expect = 7e-28
Identities = 325/1630 (19%), Positives = 688/1630 (42%), Gaps = 247/1630 (15%)
Query: 36 DMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTS 95
++ +E + E + D + KEI + L E L+ ++++ H EIQ K+ +T
Sbjct: 2184 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT- 2242
Query: 96 YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155
+LQ+ E E K D + KL A + + +T +G
Sbjct: 2243 ---RLQELEQENKLFK-------DDMEKLGLAIKESDA-----MSTQDQHVLFG------ 2281
Query: 156 AFHDDDMDFGDIISSQQ-EINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
F II ++ EI++L+ +V++L+ ++ + +++I L
Sbjct: 2282 -------KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2334
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
+ + +K+NR +EI+ + L QQ+L I ++ E + L++ L
Sbjct: 2335 MSDQECVKRNREEEIEQLNEVIEKL----QQELANIGQKTSMNAHSLSEEADSLKHQLD- 2389
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
+ +K Q+E + ++M +++ +K+ N K++ + L+R
Sbjct: 2390 ------------VVIAEKLALEQQVE--TANEEMTFMKNVLKETNFKMNQLTQELFSLKR 2435
Query: 335 EQEQLNVEKRQ-IMEECENLKLE-CSKLQPSAVKQSDTMTEKERILAQSA--SVEEVFRL 390
E+E +VEK Q I E N+ ++ SK +P E E +L + A S+E
Sbjct: 2436 ERE--SVEKIQSIPENSVNVAIDHLSKDKP----------ELEVVLTEDALKSLENQTYF 2483
Query: 391 QQALSDAENEIMRLSS--LNQDNSLAEDNLKL--------------KMRIEVLEKEKSLL 434
+ + + I+ L + L +++++ +L+L + E+L+K+ L
Sbjct: 2484 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2543
Query: 435 SQEKEELQMSLLKLNNEYEVIKSTA-----TRDISLDSELHDLRLNLEAKEQELNQSISE 489
+ EE + L + E ++ A + IS + E +++ + +E EL IS
Sbjct: 2544 QKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS- 2602
Query: 490 KETLIAEIEELDRQNQEATKHMILIKDQL---SKQQNEGDSIISKLKQDL--NDEKKRVH 544
L I EL+ Q E +IL K+Q+ K E + + +L++ L N++K+R
Sbjct: 2603 --ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2660
Query: 545 QLEDDKMDI-----TKELDVQKEK---LIQSEVALNDLHLTKQKL---EDKVENLVDQLN 593
+ + D+ T EL E+ + E + TK +L ++K E L ++L
Sbjct: 2661 EKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2720
Query: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653
+ + S+QK+ ++++H+ + +E+LS + E + + + + L + + +
Sbjct: 2721 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2780
Query: 654 LKQNLSELEQLNEN----LKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ------L 703
++ N+ +K + +++E ++ Q E + + L
Sbjct: 2781 QTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEIL 2840
Query: 704 SLEKNTI--VETLKME---KGEIEAELCWAKKRLLE-EANKYEKTIEELSNA-----RNL 752
+E I ETLK E ++ E C K +++ +K +I EL+++ R +
Sbjct: 2841 DMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI 2900
Query: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ---MDTDHKETKDVLSSSLEEQKQLTQL 809
+S + I L + +IA + E D+ K+ K +L + E Q+ L
Sbjct: 2901 CSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSL 2960
Query: 810 INK----------KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT-IEEKDRSLGSM 858
+++ L+ER + + + + K ++ R+ + + +S S
Sbjct: 2961 TESPYSDGEDHSIQQVSEPWLEERKAYI-NTISSLKDLITKMQLQREAEVYDSSQSHESF 3019
Query: 859 KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI 918
+ L L+++ E+ R+ +A +T + V LN +++ ++E+ +Q
Sbjct: 3020 SDWRGELLLALQQVFLEE-RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAA 3078
Query: 919 IED-QNQSKMQLLQSLQEQKKEMD--EFRYQHEQMNATHTQ------------LFLEKDE 963
+E Q + LL +Q +M+ + + EQ + +Q LE
Sbjct: 3079 MECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3138
Query: 964 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
E+ S++ +++ QL E+ + S++ Q TK++ KH L + E RL
Sbjct: 3139 ELSSMKDRATELQEQLSSEKMVVAELKSELAQ-TKLELETTLKAQHKH-LKELEAFRL-- 3194
Query: 1024 GIKERELEIKLLNEKNISLTKQIDQLS---KDEVGKLTQIIQQKDLEIQALHARISSTS- 1079
+K++ E+ LLN+ S K+ +L + E KL + ++ E++ L + S
Sbjct: 3195 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3254
Query: 1080 -HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ- 1137
+ Q + L+QQ Q ++K + +++ ++ L E + +++ E+ ++++
Sbjct: 3255 RNLQLNLLLEQQKQLLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3311
Query: 1138 -----DENKKLSTRFESS-----------GQDMFRETIQNL----SRII----REKDIEI 1173
D ++L + +SS +D+ +E + L SRI+ + ++
Sbjct: 3312 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3371
Query: 1174 DALSQK------CQTLLAVLQTSSTGNEAGGVNSNQF----EELLQERDKLKQQVKKMEE 1223
D+L + Q LQT N G ++ E+L ++ ++ +QQV K++
Sbjct: 3372 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3431
Query: 1224 WKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNS---KLQVDYT--GLIQSYEQNE 1278
Q++ +Q Q + +L+ E + ++L + N L D T ++Q + E
Sbjct: 3432 EGQRLQGIMQEFQKQ--ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE 3489
Query: 1279 TKLKNFGQELAQVQHSIGQLCNTK-DLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV 1337
TK N+ + + + G CN + +++ KL ++ +L +L +++E L+ ++
Sbjct: 3490 TKESNYAKLIE--MNGGGTGCNHELEMIRQKLQCVASKL---QVLPQKASERLQFETAD- 3543
Query: 1338 LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELER--KEHEQTDSEI 1395
E +Q+ ++E+ LQ+ E +S S + S ER +++ + I
Sbjct: 3544 -DEDFIWVQENIDEIILQLQKLTG---QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHI 3599
Query: 1396 KQLKEKQDVLQKLLKEKDLLIK----------AKSDQLLSSNENFTNKV-NENELLRQAV 1444
QL E+++ L+ ++ + + I+ S L+ N + +E E+ +
Sbjct: 3600 SQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREK 3659
Query: 1445 TNLKERILILEMDIGKLKGE--NEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS 1502
L++ + E ++ KLK E N+ +++T ++E+ L+ K+ LR + F
Sbjct: 3660 LTLQKSLKRAEAEVYKLKAELRNDSLLQTL-SPDSEHVTLKRIYGKY---LRAESF---- 3711
Query: 1503 MKEKALAFEQ 1512
KAL +++
Sbjct: 3712 --RKALIYQK 3719
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 179 bits (453), Expect = 3e-44
Identities = 350/1771 (19%), Positives = 727/1771 (41%), Gaps = 190/1771 (10%)
Query: 101 QQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDD 160
+QK++E K Q + K QS QS T+SS H SA HD
Sbjct: 6 RQKKLEAGKAKLAQFRQR----KAQSDGQSPSKKQKKKRKTSSSK------HDVSAHHDL 55
Query: 161 DMDFGDIISSQQEINRLS-NEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIK 219
++D Q + N + N R+ES V I +T + + +Q +L++ I
Sbjct: 56 NID-------QSQCNEMYINSSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEIS 108
Query: 220 ELKQNRSQEIDDHQHEMSVLQ--NAHQQKLTEISRRHREE-LSDYEERIEELENLLQQGG 276
+ S E++ M + N +++ + + E+ D +E +E+ L G
Sbjct: 109 TTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELA-GK 167
Query: 277 SGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQ 336
IE ++ EM+ T E +++++ E IK + ++ + RRE+
Sbjct: 168 QHEIEELNRELEEMRVTYGT------EGLQQLQEFEAAIKQRDGIITQLTANLQQARREK 221
Query: 337 EQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSD 396
++ E ++ E+ + L+++ +LQ S ++ T + L Q+ +++ QQ L +
Sbjct: 222 DETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAK--QQILTHQQQLEE 279
Query: 397 AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIK 456
++ + +D ++ L+ K+++ +E++K + + KEE+Q E E I
Sbjct: 280 QDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQ--------EKETII 331
Query: 457 STATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKD 516
EL+ + E K EL ++ + L+ E++E Q + K+M L
Sbjct: 332 E----------ELNTKIIEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELT 381
Query: 517 QLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKE-KLIQSEVALNDLH 575
+++ + I +L + + +KR H+ + DI + ++ + + KL Q L++++
Sbjct: 382 NSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEMY 441
Query: 576 LTK--QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLN- 632
+ Q ++ + + Q+ + + + + L +I NE+++ ++ N + LN
Sbjct: 442 GQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQI-KLMNVAINELNI 500
Query: 633 --QDSNSN---FKDTL---LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL-- 682
QD+NS K+ L L+E+ A R L+ + EL E +++ + + KL
Sbjct: 501 KLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNE 560
Query: 683 ----VLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEE-AN 737
+ ED++ ++ +L L+ V K++ +E E K +L+ A
Sbjct: 561 AHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKE----KNAVLDRMAE 616
Query: 738 KYEKTIEEL------SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791
E +E L S+ L+ LE EH I + + KD K+ I+ + + +
Sbjct: 617 SQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQ 676
Query: 792 TKDVLS----SSLEEQKQLTQLINKKEIFIEKL---KERSSKLQ-EELDKYSQALRKNEI 843
+ + + + +Q QL I+K + + L K LQ EL K + LR+ E
Sbjct: 677 KIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEK 736
Query: 844 LRQTIEEKDRSLG--------SMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELA 895
+ T+E++ + L MKE+ N LQE+ +L E S + KTL+ + ++
Sbjct: 737 EKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKD--EKKTLEDMLKIH 794
Query: 896 SEVSQ------LNTIKEHLEEEI--KHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQH 947
+ VSQ L++IK ++ + K + +IE+ K Q +Q +E +K+ + F +
Sbjct: 795 TPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAE 854
Query: 948 EQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENG 1007
+ + +L EE L K + ++ +++ + ++ + +E +Q +N
Sbjct: 855 KNFEVNYQEL----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTV 910
Query: 1008 SEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLE 1067
K + + K LE+ + EK+ + + +++K E +L+Q + +
Sbjct: 911 KMKSSVFDED-----KTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQ 965
Query: 1068 IQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN-SHLKTEYHKMMDIV 1126
++ H IS + ++V L+Q+ + ++ ++ ++N EN T+ ++D V
Sbjct: 966 LKQKHGEISFLN--EEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGV 1023
Query: 1127 AAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186
+ + K++ F + M + + + + E+ S++ Q +L
Sbjct: 1024 VTMTSR--GAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEE-------SKQEQLILDH 1074
Query: 1187 LQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246
L + + + ++ ++L +E + LK + Q + Q L
Sbjct: 1075 LPSVTKESSLRATQPSENDKLQKELNVLKSE--------QNDLRLQMEAQRICLSLVYST 1126
Query: 1247 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHS--IGQLCNTKDL 1304
H Q + ++++ + L LI + E+ +L+ Q Q + G L
Sbjct: 1127 HVDQVREYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHL 1186
Query: 1305 LLGKLDIISPQLSSASLLTPQSA---ECLRASKSEVLSESSELLQQELEELRK-SLQEKD 1360
L+GKL + S L T S A K EV +E E + E LQ+
Sbjct: 1187 LIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYR 1246
Query: 1361 ATIRTLQENNHRLSDSIAAT--------SELERKEHEQTDSEIKQLKEKQDVLQKLLKEK 1412
++ QEN H L + + + L + +QTD + E + L KE+
Sbjct: 1247 YEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGE-----ENLPKEE 1301
Query: 1413 DLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETY 1472
+ S + + +K + L T L+E++ LE I L+ + ++ + Y
Sbjct: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQLKETEQNY 1361
Query: 1473 RGK----ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGK---TGE- 1524
+ + QA+ E+ + S+ + + S ++ + +K+ G +GE
Sbjct: 1362 EAEIHCLQKRLQAVSESTVPPSLPV-DSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEF 1420
Query: 1525 -LNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELER 1583
+ + N VK ++++ +Q++ ++ + + A Q E+ R+ + N +
Sbjct: 1421 GVKEETNIVKLLEKQ---YQEQLEEEVAKVIVSMSIAFAQQTELSRISGG--KENTASSK 1475
Query: 1584 LRNHLLESEDSYTREALAAEDR---------EAKLRKKVTVLEEKL------VSSSNAME 1628
+ + + E Y E ++D+ + K +++ L ++L + SN+
Sbjct: 1476 QAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGEHGKEILLSNSDP 1535
Query: 1629 NASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMV----LEHFQ 1684
+ ++ V ++ E++ +D+T + +++ ++ + M+ LE +
Sbjct: 1536 HDIPESKDCVLTISEEMF----SKDKTFIVRQSIHDEISVSSMDASRQLMLNEEQLEDMR 1591
Query: 1685 QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKE 1744
QE Y + + L + E LQE + N L S + + V E
Sbjct: 1592 QELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSIDNENLVSE 1651
Query: 1745 EQIEELKRQNELRQEMLDDVQKKLMSLANSS 1775
+ L+ L+Q L +K L NSS
Sbjct: 1652 RERVLLEELEALKQLSLAGREKLCCELRNSS 1682
Score = 173 bits (438), Expect = 2e-42
Identities = 357/1693 (21%), Positives = 703/1693 (41%), Gaps = 252/1693 (14%)
Query: 40 EGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQ 99
E TE + + ++I+ H S + L+K T LEE+ + E I +
Sbjct: 1300 EETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEK--TKLEEQVQELESLISSLQQQLKET 1357
Query: 100 LQQKEVEISHLKARQIALQDQLLKLQSAAQS-VPSGAGVPATTASSSFAYGISHHPSAFH 158
Q E EI L+ R LQ+ ++S VP V + + S A + +P +
Sbjct: 1358 EQNYEAEIHCLQKR----------LQAVSESTVPPSLPVDSVVITESDAQR-TMYPGSCV 1406
Query: 159 DDDMDFGDIISSQQEINRLSNEVSRLESEVGHW--RHIAQTSKAQGTDNSDQSEICKLQN 216
++D S + + +N V LE + +A+ + + Q+E+ ++
Sbjct: 1407 KKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISG 1466
Query: 217 IIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTE--ISRRHREELS-DYEERIEELENLLQ 273
K+N + H ++ KL++ I + E + ++E + L L
Sbjct: 1467 G----KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELG 1522
Query: 274 QGGSGVI--ETDLSKIYEMQKTIQVLQIEKVESTKKM---EQLEDKIKDINKKLSSAEND 328
+ G ++ +D I E + + + E K + + D+I +SS +
Sbjct: 1523 EHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEIS-----VSSMDAS 1577
Query: 329 RDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVF 388
R ++ E EQL +++++ + + + L+ + ++Q + E + L EE+
Sbjct: 1578 RQLMLNE-EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQ-----EEIK 1631
Query: 389 RLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKE--ELQMSLL 446
RL + L+ SS++ +N ++E L +E L K+ SL +EK EL+ S
Sbjct: 1632 RLNRQLAQR-------SSIDNENLVSERERVLLEELEAL-KQLSLAGREKLCCELRNSST 1683
Query: 447 KLNNEYE---VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEK--ETLIAEIEELD 501
+ N E ++ ++ LD + D+ + + E+ Q + + + L+ ++
Sbjct: 1684 QTQNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTA 1743
Query: 502 RQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQK 561
+ +H++ I D+ SK Q+ S+I + + + + K VH+ + T+ D
Sbjct: 1744 AVEETIGRHVLGILDRSSKSQSSA-SLIWRSEAEAS-VKSCVHE------EHTRVTDESI 1795
Query: 562 EKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS 621
S++ ND+++ + E+ E L +L +S + I EN EL +I L
Sbjct: 1796 PSYSGSDMPRNDINMWSKVTEEGTE-LSQRLVRSGFAGTEIDPENEELMLNI---SSRLQ 1851
Query: 622 RIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEK 681
+L++++++ S+ L + L + +F K E +
Sbjct: 1852 AAVEKLLEAISETSSQ--------------------LEHAKVTQTELMRESFRQKQEATE 1891
Query: 682 LVLACEDVRHQLEECLAGNNQLSLE-------------KNTIVETLKMEKGEI----EAE 724
+ E++R +L E QL++E + T+ E EK +I E E
Sbjct: 1892 SLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQE 1951
Query: 725 LCWAKKRLLE---EANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKN 781
L A RL E E + ++ E LS + + + L++ +K E E++
Sbjct: 1952 LLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQ 2011
Query: 782 IEQMDTDHKETKDVLSSSLEEQ-KQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
E++ D ++ L +EEQ + +L +K + L++++ L+++L+K + L +
Sbjct: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071
Query: 841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS---RTAPVADPKTLDSVTELASE 897
I R+ E + Q+E+++L ++ R P+++ +T + V +LA+
Sbjct: 2072 QAIDRE-------------HERDVFQQEIQKLEQQLKVVPRFQPISEHQTRE-VEQLANH 2117
Query: 898 V-------SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQ-EQKKEMDEFRYQHEQ 949
+ S+L KE L+ +I+ + IE +L Q+L E +K + E
Sbjct: 2118 LKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPEL 2177
Query: 950 MNATHTQLFLEKD------EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLN 1003
+ QL E+D +EI +L++ +EQ + +L + +++Q + + + K +
Sbjct: 2178 --SLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTTR 2235
Query: 1004 IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQ 1063
++ +++ L K + E+L IKE + +++ Q + GK QIIQ+
Sbjct: 2236 LQELEQENKLFKDDMEKLGLAIKESD-----------AMSTQDQHVL---FGKFAQIIQE 2281
Query: 1064 KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMM 1123
K++EI L+ + V LQQQL+ + V+ EK L+T+ +M
Sbjct: 2282 KEVEIDQLN---------EQVTKLQQQLKITTDNK-----VIEEKNELIRDLETQIECLM 2327
Query: 1124 D----IVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQK 1179
+ +E + +L + +KL + GQ +T N + E D L
Sbjct: 2328 SDQECVKRNREEEIEQLNEVIEKLQQELANIGQ----KTSMNAHSLSEEADSLKHQLDVV 2383
Query: 1180 CQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHES 1239
LA+ Q T N EE+ ++ LK+ KM + Q++ + + ES
Sbjct: 2384 IAEKLALEQQVETAN----------EEMTFMKNVLKETNFKMNQLTQELFSL--KRERES 2431
Query: 1240 AQLQEELHQLQAQVLVD--SDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
+ + + + V +D S + +L+V T +N+T K+F ++ G
Sbjct: 2432 VEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFKSF------EENGKGS 2485
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASK--SEVLSESSELLQQELEELRKS 1355
+ N + LL +L+ S+ S + +C + K E +E+LQ+++ L+K
Sbjct: 2486 IINLETRLL-QLE------STVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQKI 2538
Query: 1356 LQEKDAT-------IRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKL 1408
++EK A + +QE D+ +SE ER + + QL+E D L
Sbjct: 2539 VEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQ----NLNQLRE--DELGSD 2592
Query: 1409 LKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKI 1468
+ L I Q++ E T+ + E E + A N+ E+ L +++ KL NEK
Sbjct: 2593 ISALTLRISELESQVV---EMHTSLILEKEQVEIAEKNVLEKEKKL-LELQKLLEGNEK- 2647
Query: 1469 VETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQL 1528
K+ E +EK+ ++ E +E G EL L
Sbjct: 2648 ------KQRE---------------KEKKRSPQDVEVLKTTTELFHSNEESGFFNELEAL 2686
Query: 1529 LNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHL 1588
+ + + ++++ +++ L K+ T+LQ ++ ++RD + ++L L
Sbjct: 2687 RAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKE- 2745
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKL--VSSSN-----AMENASHQASVQVESL 1641
E+E +++A E KL K + + +SSSN ++NA Q ++Q E
Sbjct: 2746 DETEVQESKKACMFEPLPIKLSKSIASQTDGTLKISSSNQTPQILVKNAGIQINLQSECS 2805
Query: 1642 QEQLNVVSKQRDE 1654
E++ + Q E
Sbjct: 2806 SEEVTEIISQFTE 2818
Score = 171 bits (433), Expect = 7e-42
Identities = 361/1737 (20%), Positives = 727/1737 (41%), Gaps = 263/1737 (15%)
Query: 202 GTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAH--QQKLTEISRRHREELS 259
GT+ ++E L NI L+ + ++ S L++A Q +L S R ++E +
Sbjct: 1832 GTEIDPENEELML-NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEAT 1890
Query: 260 DYEERIEELENLLQQGGSG--VIETDLSKI------YEMQKTIQVLQI-EKVESTKKMEQ 310
+ + EEL L + + +LSK Y +KT+ QI EK + ++EQ
Sbjct: 1891 ESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQ 1950
Query: 311 ----LEDKIKDINKKLSSAENDRDILRREQEQLNVE----KRQIMEECENLKLECSKLQP 362
++++++ + + +R++L R++E + E ++Q+++E E L E ++Q
Sbjct: 1951 ELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQC 2010
Query: 363 SAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM 422
A K D + ++ + L E+V R + + E+M L Q N E L+ KM
Sbjct: 2011 QAEKVRDDLQKQVKALEIDVE-EQVSRFIELEQEKNTELM---DLRQQNQALEKQLE-KM 2065
Query: 423 RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQE 482
R + L+++ E++ Q + KL + +V+ E+ L +L+ K +
Sbjct: 2066 R-KFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQTREVEQLANHLKEKTDK 2124
Query: 483 LNQSISEKETLIAEIEELDRQNQ---------------EATKHM--ILIKDQLSKQ---Q 522
++ + KE L +I+E + + + E KH + K +LS + Q
Sbjct: 2125 CSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEVQLQ 2184
Query: 523 NEGDSI------ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHL 576
E D+I I+ L++ L ++ + ++ + +L++QK+ +S L +L
Sbjct: 2185 AERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKK---ESTTRLQELEQ 2241
Query: 577 TKQKLEDKVENLVDQLNKSQESNVSIQKENL---ELKEHIRQNEEELSRIRNELMQSLNQ 633
+ +D +E L + +S +S Q +++ + + I++ E E+ ++ NE + L Q
Sbjct: 2242 ENKLFKDDMEKLGLAIKESDA--MSTQDQHVLFGKFAQIIQEKEVEIDQL-NEQVTKLQQ 2298
Query: 634 DSNSNFKDTLLKEREAEVRNLKQNLS---------------ELEQLNENLKKVAFDV--- 675
+ +++E+ +R+L+ + E+EQLNE ++K+ ++
Sbjct: 2299 QLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEVIEKLQQELANI 2358
Query: 676 ----KMENEKLVLACEDVRHQLEECLA-----------GNNQLSLEKNTIVETLKMEKGE 720
M L + ++HQL+ +A N +++ KN + ET + +
Sbjct: 2359 GQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKET-NFKMNQ 2417
Query: 721 IEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKK 780
+ EL ++ KR E K + E N + S + E E ++ + K +E K
Sbjct: 2418 LTQEL-FSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2476
Query: 781 NIEQ--------MDTDHKETKDVLSSSLEE----QKQLTQLINKKEIFIEKLKERSSKLQ 828
+ E+ ++T + + +S+ E KQ+ + + + E L+++ LQ
Sbjct: 2477 SFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNLQ 2536
Query: 829 EELDKYSQALRKNEILRQTIEE-----KDRSLGSMKEENNHLQEELERLREEQSRTAPVA 883
+ +++ A ++I + ++E +D S + E ++Q L +LRE++ + A
Sbjct: 2537 KIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQN-LNQLREDELGSDISA 2595
Query: 884 DPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEF 943
TL ++EL S+V +++T +E+++ +K + ++ + ++L + L+ +K+ E
Sbjct: 2596 --LTL-RISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2652
Query: 944 RYQHEQMNA----THTQLFLEKDE-----EIKSLQKTIEQIKTQLHEERQDIQTDNSDIF 994
+ + T T+LF +E E+++L+ K +L ++ + ++
Sbjct: 2653 EKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2712
Query: 995 -QETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQID-QLSKD 1052
+ET + SL + + L++A+ E+L I E+E E ++ K + + + +LSK
Sbjct: 2713 VKETNMTSLQKDLSQVRDHLAEAK-EKL--SILEKEDETEVQESKKACMFEPLPIKLSKS 2769
Query: 1053 EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN 1112
I Q D + +ISS++ T ++ +Q E T
Sbjct: 2770 -------IASQTDGTL-----KISSSNQTPQILVKNAGIQINLQSE----CSSEEVTEII 2813
Query: 1113 SHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIE 1172
S + KM ++ AA+ DM I + RE +
Sbjct: 2814 SQFTEKIEKMQELHAAEIL---------------------DMESRHISETETLKREHYVA 2852
Query: 1173 IDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTT- 1231
+ L ++C TL AV+Q + E + + Q R+ +W Q + T
Sbjct: 2853 VQLLKEECGTLKAVIQCLRS-KEGSSIPELAHSDAYQTREICSSD--SGSDWGQGIYLTH 2909
Query: 1232 ------VQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS-YEQNETKLKNF 1284
+ E ++ + + + L+ + +N +QV L +S Y E
Sbjct: 2910 SQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQV--LSLTESPYSDGEDHSIQQ 2967
Query: 1285 GQE--LAQVQHSIGQLCNTKDLL----LGKLDIISPQLSSASLLTPQSAECLRASKSEVL 1338
E L + + I + + KDL+ L + + S + E L A + L
Sbjct: 2968 VSEPWLEERKAYINTISSLKDLITKMQLQREAEVYDSSQSHESFSDWRGELLLALQQVFL 3027
Query: 1339 SESSELLQQELEELRKSLQEKDAT--IRTLQENNHRLSDSIAATSE-LERKEHEQTDSEI 1395
E S LL EL +L DA + L++ A E L++ + SEI
Sbjct: 3028 EERSVLLAAFRTELT-ALGTTDAVGLLNCLEQRIQEQGVEYQAAMECLQKADRRSLLSEI 3086
Query: 1396 KQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENEL----LRQAVTNLKERI 1451
+ L + + + LK + K + L + + +++ E ++ ++ T L+E++
Sbjct: 3087 QALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDRATELQEQL 3146
Query: 1452 LILEMDIGKLKGENEKIVETYRGKETEYQALQETNMK----FSMMLREKEFECHSMKEKA 1507
+M + +LK E + +T ET +A Q ++K F + +++K E H + +
Sbjct: 3147 SSEKMVVAELKSE---LAQTKLELETTLKA-QHKHLKELEAFRLEVKDKTDEVHLLND-T 3201
Query: 1508 LAFEQLLK-------EKEQGKTG--------ELNQLLNAVKSMQEKTVVFQQERDQVMLA 1552
LA EQ EKE+ K G EL L +++S +++ + +L
Sbjct: 3202 LASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQLN------LLL 3255
Query: 1553 LKQKQMENTALQN-EVQR-LRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLR 1610
+QKQ+ N + Q E QR L D + Q LLESE RE + DRE +L
Sbjct: 3256 EQQKQLLNESQQKIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELH 3315
Query: 1611 KKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYA 1670
+ L SS ++ S ++ L + KQ +E ++ + ++Y
Sbjct: 3316 AQ-------LQSSDGTGQSRPPLPS------EDLLKELQKQLEEKHSRIVELLNETEKYK 3362
Query: 1671 LSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAAL 1730
L + +E +++ ++ L+ +++ E +K L+ KV LQ
Sbjct: 3363 LDSLQTRQQME----KDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQR--------- 3409
Query: 1731 DSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGKVDKVLMRNL 1787
QL+ K +Q+ +L + + Q ++ + QK+ + E + ++L +NL
Sbjct: 3410 --------QLEEKRQQVYKLDLEGQRLQGIMQEFQKQELEREEKRESR--RILYQNL 3456
Score = 167 bits (423), Expect = 9e-41
Identities = 370/1893 (19%), Positives = 779/1893 (41%), Gaps = 297/1893 (15%)
Query: 29 QISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENER---LKKLCTDLEEKHEAS 85
++ + + ++ +EE+ ++ + + KEIE ILR E + L++ +L+ K E
Sbjct: 701 KLKDLQQSLVNSKSEEMTLQINELQ-KEIE----ILRQEEKEKGTLEQEVQELQLKTELL 755
Query: 86 EIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSS 145
E Q+K++ + + Q E E S LK + L+D +LK+ + + + + S
Sbjct: 756 EKQMKEKENDLQEKFAQLEAENSILKDEKKTLED-MLKIHTPVSQEERLIFLDSIKSKSK 814
Query: 146 FAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDN 205
D + +I +E L + +L E+ R+ ++ N
Sbjct: 815 --------------DSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVN 860
Query: 206 SD--QSEICKLQNIIKELKQNRSQEIDDHQHEMSVL-QNAHQQKLTEISRRHREELSDYE 262
Q E L + +L+ +++++ +++ ++ L + H Q++ + + + + D +
Sbjct: 861 YQELQEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDED 920
Query: 263 ERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKME-QLEDKIKDINKK 321
+ + L+ G V+E D +++ +EK+E TK+ + +L ++ D++++
Sbjct: 921 KTF--VAETLEMG--EVVEKDTTEL-----------MEKLEVTKREKLELSQRLSDLSEQ 965
Query: 322 LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEK--ERILA 379
L + L E + L EK Q+ C L++ + + V+ DT + ++
Sbjct: 966 LKQKHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVT 1025
Query: 380 QSASVEE--VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKM----RIEVLEKEKSL 433
++ E V ++ ++ + E++IM ++ +N + K + + + KE SL
Sbjct: 1026 MTSRGAEGSVSKVNKSFGE-ESKIMVEDKVSFENMTVGEESKQEQLILDHLPSVTKESSL 1084
Query: 434 LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETL 493
+ + E KL E V+K SE +DLRL +EA+ L+ S
Sbjct: 1085 RATQPSEND----KLQKELNVLK----------SEQNDLRLQMEAQRICLSLVYSTHVDQ 1130
Query: 494 IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL---------KQDLNDEKKRVH 544
+ E E E K + +K++L Q E + K+ Q+ DE K +H
Sbjct: 1131 VREYME-----NEKDKALCSLKEELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLH 1185
Query: 545 QLEDDKMDITKELDVQKEKLIQSEVALNDLHLT-----KQKLEDKVENLVDQLNKSQESN 599
L + K + + +Q+ ++ + T + EDK EN D ++++++
Sbjct: 1186 LLIG---KLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDK-ENSGDYISENEDPE 1241
Query: 600 V--------SIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNS---NFKDTLLKERE 648
+ Q+ L + + +L ++ L + Q ++ F + L + E
Sbjct: 1242 LQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEE 1301
Query: 649 AEVRNLKQNLSELEQLNENLK-KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEK 707
E ++ ++ LE ++ N K K++ +E KL E+ +LE +
Sbjct: 1302 TEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKL----EEQVQELESLI---------- 1347
Query: 708 NTIVETLKMEKGEIEAELCWAKKRLLEEANKY--------EKTIEELSNARNLNTSALQL 759
+++ + LK + EAE+ +KRL + I E R + +
Sbjct: 1348 SSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVK 1407
Query: 760 EH-----EHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSL--EEQKQLTQLINK 812
++ E + K++ I +L + Q + + K ++S S+ +Q +L+++
Sbjct: 1408 KNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGG 1467
Query: 813 KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL 872
KE + + QE+ L +++I QT E D KEE L +EL
Sbjct: 1468 KENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVD---VKFKEEFKPLSKELGEH 1524
Query: 873 REE--QSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930
+E S + P P++ D V ++ E+ + K + + H + + + S+ +L
Sbjct: 1525 GKEILLSNSDPHDIPESKDCVLTISEEM--FSKDKTFIVRQSIHDEISVSSMDASRQLML 1582
Query: 931 --QSLQEQKKEMDEFRYQHEQ----MNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQ 984
+ L++ ++E+ +H+Q + H + + E+ + LQ+ I+++ QL +R
Sbjct: 1583 NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQL-AQRS 1641
Query: 985 DIQTDN------------------------SDIFQETKVQSLNIENGSEKHDLSKAETER 1020
I +N + E + S +NG+E + +T
Sbjct: 1642 SIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSSTQTQNGNENQGEVEEQT-- 1699
Query: 1021 LVKGIKERELEIK-------LLNEKNISLTKQIDQLSKD--EVGKLTQIIQQK-DLEIQA 1070
KE+EL+ K +L+ + +L K ++L K EV K T +++ +
Sbjct: 1700 ----FKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVEETIGRHVLG 1755
Query: 1071 LHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKE 1130
+ R S + + +++ + E V E TR Y D+
Sbjct: 1756 ILDRSSKSQSSASLIWRSE------AEASVKSCVHEEHTRVTDESIPSY-SGSDMPRNDI 1808
Query: 1131 AALIKLQDENKKLSTRFESS---GQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVL 1187
K+ +E +LS R S G ++ E + + I ++ L L A+
Sbjct: 1809 NMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKL------LEAIS 1862
Query: 1188 QTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELH 1247
+TSS A + E +++ + + +K EE ++++ HE ++ +E+L
Sbjct: 1863 ETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERL--------HEESRAREQL- 1913
Query: 1248 QLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLG 1307
+ SK + G+I Y +T + QE + + Q L
Sbjct: 1914 ---------AVELSKAE----GVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQ 1960
Query: 1308 KLDIISPQLSSASLLTPQSAECLRAS----KSEVLSESSELLQQELEELRKSLQEKDATI 1363
+L+ Q+ L + E ++A + ++L E+ +L++++LE ++ + +D
Sbjct: 1961 ELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQ 2020
Query: 1364 RTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQL 1423
+ ++ + + ++ ELE ++ ++E+ L+++ L+K L++ +
Sbjct: 2021 KQVKALEIDVEEQVSRFIELE----QEKNTELMDLRQQNQALEKQLEKMRKFL------- 2069
Query: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQA-- 1481
+E ++ +E ++ +Q + L++++ ++ + + ++ +E E A
Sbjct: 2070 ---DEQAIDREHERDVFQQEIQKLEQQLKVV---------PRFQPISEHQTREVEQLANH 2117
Query: 1482 LQETNMKFSMMLREKEFECHSMKEKALAFEQL---LKEKEQGKTGELNQLLNAVKSMQEK 1538
L+E K S +L KE ++E+ E+L ++E EQ E + AV++ E
Sbjct: 2118 LKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPEL 2177
Query: 1539 T--VVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHL-------- 1588
+ V Q ERD A+ +K+ E T L+ ++++ R++ N+E+++L L
Sbjct: 2178 SLEVQLQAERD----AIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKEST 2233
Query: 1589 -----LESE-----DSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQV 1638
LE E D + LA ++ +A + VL K E Q + QV
Sbjct: 2234 TRLQELEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQV 2293
Query: 1639 ESLQEQL-----NVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSA 1693
LQ+QL N V ++++E L E L + Q ++ ++EE +
Sbjct: 2294 TKLQQQLKITTDNKVIEEKNELIRDLETQIE-------CLMSDQECVKRNREEEIEQLNE 2346
Query: 1694 ELEKQKQLIA----EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEE 1749
+EK +Q +A + NA +L + SL+ LD + L +Q++ E++
Sbjct: 2347 VIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLD---VVIAEKLALEQQVETANEEMTF 2403
Query: 1750 LKRQNELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
+K + ++ + ++L SL E V+K+
Sbjct: 2404 MKNVLKETNFKMNQLTQELFSLKRERE-SVEKI 2435
Score = 160 bits (404), Expect = 2e-38
Identities = 316/1641 (19%), Positives = 672/1641 (40%), Gaps = 246/1641 (14%)
Query: 254 HREELSDYEERIEELENLLQQGGSG--VIETDLSKIYEMQKTIQVLQIEKVESTKKMEQL 311
+R E+ D++E + L N + + + V++T LSKI+ Q L+ + K+
Sbjct: 1245 YRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKE---- 1300
Query: 312 EDKIKDINKKLSSAENDRDILRREQ--EQLNVEKRQIMEECENLKLECSKLQPSAVKQSD 369
E + I+ ++++ E D D+ + + ++EK ++ E+ + L+ S LQ +K+++
Sbjct: 1301 ETEFLSIHSQMTNLE-DIDVNHKSKLSSLQDLEKTKLEEQVQELESLISSLQQQ-LKETE 1358
Query: 370 TMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLK----LKMRIE 425
E E Q RLQ + + S+ S A+ + +K I+
Sbjct: 1359 QNYEAEIHCLQK-------RLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNID 1411
Query: 426 VLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQ 485
+ ++E + LL+ + ++ + A +S+ A++ EL++
Sbjct: 1412 GTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAF--------AQQTELSR 1463
Query: 486 SISEKETLIA--EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISK-----LKQDLND 538
KE + + + +Q Q M L +DQ+ Q E + K L ++L +
Sbjct: 1464 ISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE 1523
Query: 539 EKKRVHQLEDDKMDITKELD---------------------VQKEKLIQSEVALNDLHLT 577
K + D DI + D + E + S A L L
Sbjct: 1524 HGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQSIHDEISVSSMDASRQLMLN 1583
Query: 578 KQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNS 637
+++LED + LV Q + Q++ +++ ++ E R+++E+L L + L Q S+
Sbjct: 1584 EEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRLNRQLAQRSSI 1643
Query: 638 NFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
+ + L+ ERE R L + L L+QL+ EKL C ++R+ +
Sbjct: 1644 D-NENLVSERE---RVLLEELEALKQLS----------LAGREKL---CCELRNSSTQTQ 1686
Query: 698 AGN-NQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEAN-----------KYEKTIE 744
GN NQ +E+ T E L + ++ E+ ++ L++AN K +E
Sbjct: 1687 NGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKTTAAVE 1746
Query: 745 ELSNARNLN---------------------TSALQLEHEHLIKLNQKK--DMEIAELKKN 781
E L S HE ++ + +++ +N
Sbjct: 1747 ETIGRHVLGILDRSSKSQSSASLIWRSEAEASVKSCVHEEHTRVTDESIPSYSGSDMPRN 1806
Query: 782 IEQMDTDHKETKDVLSSSL------------EEQKQLTQLINKKEIFIEKLKERSSKLQE 829
M + E LS L E ++ + + ++ + +EKL E S+
Sbjct: 1807 DINMWSKVTEEGTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSS 1866
Query: 830 ELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLD 889
+L+ + + E++R++ +K + S+K QEEL E+SR
Sbjct: 1867 QLEHAK--VTQTELMRESFRQKQEATESLK-----CQEELRERLHEESRARE-------- 1911
Query: 890 SVTELASEVSQLNTI-------KEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 942
+LA E+S+ + K E +I+ II+ Q + LQE + E +
Sbjct: 1912 ---QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQ 1968
Query: 943 FRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSL 1002
+ + E ++ + E + L + E++ + E + + D+ ++ K +
Sbjct: 1969 IQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEI 2028
Query: 1003 NIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQ 1062
++E + R ++ +E+ E+ L ++N +L KQ++++
Sbjct: 2029 DVEE----------QVSRFIELEQEKNTELMDLRQQNQALEKQLEKM------------- 2065
Query: 1063 QKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRE----NSHLKTE 1118
+K L+ QA+ Q++ L+QQL+ + + +TRE +HLK +
Sbjct: 2066 RKFLDEQAIDREHERDVFQQEIQKLEQQLKVVP----RFQPISEHQTREVEQLANHLKEK 2121
Query: 1119 YHKMMDIVAAKEAALIKLQDENK---KLSTRFESSGQDMFRETIQNLSRIIREKDIEIDA 1175
K +++ +KE +Q+ N+ KL R Q + E ++ + + ++ ++
Sbjct: 2122 TDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVEDRKHFGAVEAKPELSLEV 2181
Query: 1176 LSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVK-KMEEWKQQVMTTVQN 1234
Q + + + T E QF E L+ +++ QQ+ ++E K++ T +Q
Sbjct: 2182 QLQAERDAIDRKEKEITNLEE---QLEQFREELENKNEEVQQLHMQLEIQKKESTTRLQE 2238
Query: 1235 MQHESAQLQEELHQLQAQVLV-DSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQH 1293
++ E+ ++++ +L + D+ + V + Q ++ E ++ +++ ++Q
Sbjct: 2239 LEQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQ 2298
Query: 1294 SIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELR 1353
+ ++ ++ K ++I + L EC++ ++ E + + +E++++ +EL
Sbjct: 2299 QL-KITTDNKVIEEKNELIRDLETQIECLMSDQ-ECVKRNREEEIEQLNEVIEKLQQELA 2356
Query: 1354 KSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKD 1413
Q+ +L E +DS+ ++ E + +++ E+ ++ +LKE +
Sbjct: 2357 NIGQKTSMNAHSLSEE----ADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETN 2412
Query: 1414 LLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMD-IGKLKGENEKIVETY 1472
+ + +L S E E + + + ++ E + + +D + K K E E ++
Sbjct: 2413 FKMNQLTQELFSLKR-------ERESVEK-IQSIPENSVNVAIDHLSKDKPELEVVLTED 2464
Query: 1473 RGKETEYQALQ---ETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLL 1529
K E Q E N K S++ +++ + L E + K+ EL Q
Sbjct: 2465 ALKSLENQTYFKSFEENGKGSII---------NLETRLLQLESTVSAKDL----ELTQCY 2511
Query: 1530 NAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLL 1589
+K MQE+ Q + QK++ N LQ V+ S +LE ++ +
Sbjct: 2512 KQIKDMQEQ--------GQFETEMLQKKIVN--LQKIVEEKVAAALVSQIQLEAVQEYAK 2561
Query: 1590 ESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVS 1649
+D+ T +++E ++ + E++L S +A+ + QV + L ++
Sbjct: 2562 FCQDNQT---ISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSL-ILE 2617
Query: 1650 KQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ----QEEKAMYSAELEKQKQLIAEW 1705
K+ Q+ ++++ V + L LQ +LE + ++EK ++E K +
Sbjct: 2618 KE------QVEIAEKNVLEKEKKLLELQKLLEGNEKKQREKEKKRSPQDVEVLKTTTELF 2671
Query: 1706 KKNAEN---LEGKVISLQECLDEANAAL--DSASRLTEQLDVKEEQIEELKRQNELRQEM 1760
N E+ E + + + +A A + A +L E+L VKE + L++ ++
Sbjct: 2672 HSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSLQKDLSQVRDH 2731
Query: 1761 LDDVQKKLMSLANSSEGKVDK 1781
L + ++KL L E +V +
Sbjct: 2732 LAEAKEKLSILEKEDETEVQE 2752
Score = 124 bits (312), Expect = 7e-28
Identities = 325/1630 (19%), Positives = 688/1630 (42%), Gaps = 247/1630 (15%)
Query: 36 DMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTS 95
++ +E + E + D + KEI + L E L+ ++++ H EIQ K+ +T
Sbjct: 2176 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT- 2234
Query: 96 YRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPS 155
+LQ+ E E K D + KL A + + +T +G
Sbjct: 2235 ---RLQELEQENKLFK-------DDMEKLGLAIKESDA-----MSTQDQHVLFG------ 2273
Query: 156 AFHDDDMDFGDIISSQQ-EINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
F II ++ EI++L+ +V++L+ ++ + +++I L
Sbjct: 2274 -------KFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIRDLETQIECL 2326
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
+ + +K+NR +EI+ + L QQ+L I ++ E + L++ L
Sbjct: 2327 MSDQECVKRNREEEIEQLNEVIEKL----QQELANIGQKTSMNAHSLSEEADSLKHQLD- 2381
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
+ +K Q+E + ++M +++ +K+ N K++ + L+R
Sbjct: 2382 ------------VVIAEKLALEQQVE--TANEEMTFMKNVLKETNFKMNQLTQELFSLKR 2427
Query: 335 EQEQLNVEKRQ-IMEECENLKLE-CSKLQPSAVKQSDTMTEKERILAQSA--SVEEVFRL 390
E+E +VEK Q I E N+ ++ SK +P E E +L + A S+E
Sbjct: 2428 ERE--SVEKIQSIPENSVNVAIDHLSKDKP----------ELEVVLTEDALKSLENQTYF 2475
Query: 391 QQALSDAENEIMRLSS--LNQDNSLAEDNLKL--------------KMRIEVLEKEKSLL 434
+ + + I+ L + L +++++ +L+L + E+L+K+ L
Sbjct: 2476 KSFEENGKGSIINLETRLLQLESTVSAKDLELTQCYKQIKDMQEQGQFETEMLQKKIVNL 2535
Query: 435 SQEKEELQMSLLKLNNEYEVIKSTA-----TRDISLDSELHDLRLNLEAKEQELNQSISE 489
+ EE + L + E ++ A + IS + E +++ + +E EL IS
Sbjct: 2536 QKIVEEKVAAALVSQIQLEAVQEYAKFCQDNQTISSEPERTNIQNLNQLREDELGSDIS- 2594
Query: 490 KETLIAEIEELDRQNQEATKHMILIKDQL---SKQQNEGDSIISKLKQDL--NDEKKRVH 544
L I EL+ Q E +IL K+Q+ K E + + +L++ L N++K+R
Sbjct: 2595 --ALTLRISELESQVVEMHTSLILEKEQVEIAEKNVLEKEKKLLELQKLLEGNEKKQREK 2652
Query: 545 QLEDDKMDI-----TKELDVQKEK---LIQSEVALNDLHLTKQKL---EDKVENLVDQLN 593
+ + D+ T EL E+ + E + TK +L ++K E L ++L
Sbjct: 2653 EKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYKEKAEKLQEELL 2712
Query: 594 KSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRN 653
+ + S+QK+ ++++H+ + +E+LS + E + + + + L + + +
Sbjct: 2713 VKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEPLPIKLSKSIAS 2772
Query: 654 LKQNLSELEQLNEN----LKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQ------L 703
++ N+ +K + +++E ++ Q E + + L
Sbjct: 2773 QTDGTLKISSSNQTPQILVKNAGIQINLQSECSSEEVTEIISQFTEKIEKMQELHAAEIL 2832
Query: 704 SLEKNTI--VETLKME---KGEIEAELCWAKKRLLE-EANKYEKTIEELSNA-----RNL 752
+E I ETLK E ++ E C K +++ +K +I EL+++ R +
Sbjct: 2833 DMESRHISETETLKREHYVAVQLLKEECGTLKAVIQCLRSKEGSSIPELAHSDAYQTREI 2892
Query: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ---MDTDHKETKDVLSSSLEEQKQLTQL 809
+S + I L + +IA + E D+ K+ K +L + E Q+ L
Sbjct: 2893 CSSDSGSDWGQGIYLTHSQGFDIASEGRGEESESATDSFPKKIKGLLRAVHNEGMQVLSL 2952
Query: 810 INK----------KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQT-IEEKDRSLGSM 858
+++ L+ER + + + + K ++ R+ + + +S S
Sbjct: 2953 TESPYSDGEDHSIQQVSEPWLEERKAYI-NTISSLKDLITKMQLQREAEVYDSSQSHESF 3011
Query: 859 KEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKI 918
+ L L+++ E+ R+ +A +T + V LN +++ ++E+ +Q
Sbjct: 3012 SDWRGELLLALQQVFLEE-RSVLLAAFRTELTALGTTDAVGLLNCLEQRIQEQGVEYQAA 3070
Query: 919 IED-QNQSKMQLLQSLQEQKKEMD--EFRYQHEQMNATHTQ------------LFLEKDE 963
+E Q + LL +Q +M+ + + EQ + +Q LE
Sbjct: 3071 MECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELLEYNIQQKQSQMLEMQV 3130
Query: 964 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVK 1023
E+ S++ +++ QL E+ + S++ Q TK++ KH L + E RL
Sbjct: 3131 ELSSMKDRATELQEQLSSEKMVVAELKSELAQ-TKLELETTLKAQHKH-LKELEAFRL-- 3186
Query: 1024 GIKERELEIKLLNEKNISLTKQIDQLS---KDEVGKLTQIIQQKDLEIQALHARISSTS- 1079
+K++ E+ LLN+ S K+ +L + E KL + ++ E++ L + S
Sbjct: 3187 EVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEERDKEELEDLKFSLESQKQ 3246
Query: 1080 -HTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQ- 1137
+ Q + L+QQ Q ++K + +++ ++ L E + +++ E+ ++++
Sbjct: 3247 RNLQLNLLLEQQKQLLNESQQK---IESQRMLYDAQLSEEQGRNLELQVLLESEKVRIRE 3303
Query: 1138 -----DENKKLSTRFESS-----------GQDMFRETIQNL----SRII----REKDIEI 1173
D ++L + +SS +D+ +E + L SRI+ + ++
Sbjct: 3304 MSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKL 3363
Query: 1174 DALSQK------CQTLLAVLQTSSTGNEAGGVNSNQF----EELLQERDKLKQQVKKMEE 1223
D+L + Q LQT N G ++ E+L ++ ++ +QQV K++
Sbjct: 3364 DSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDL 3423
Query: 1224 WKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNS---KLQVDYT--GLIQSYEQNE 1278
Q++ +Q Q + +L+ E + ++L + N L D T ++Q + E
Sbjct: 3424 EGQRLQGIMQEFQKQ--ELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGE 3481
Query: 1279 TKLKNFGQELAQVQHSIGQLCNTK-DLLLGKLDIISPQLSSASLLTPQSAECLRASKSEV 1337
TK N+ + + + G CN + +++ KL ++ +L +L +++E L+ ++
Sbjct: 3482 TKESNYAKLIE--MNGGGTGCNHELEMIRQKLQCVASKL---QVLPQKASERLQFETAD- 3535
Query: 1338 LSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELER--KEHEQTDSEI 1395
E +Q+ ++E+ LQ+ E +S S + S ER +++ + I
Sbjct: 3536 -DEDFIWVQENIDEIILQLQKLTG---QQGEEPSLVSPSTSCGSLTERLLRQNAELTGHI 3591
Query: 1396 KQLKEKQDVLQKLLKEKDLLIK----------AKSDQLLSSNENFTNKV-NENELLRQAV 1444
QL E+++ L+ ++ + + I+ S L+ N + +E E+ +
Sbjct: 3592 SQLTEEKNDLRNMVMKLEEQIRWYRQTGAGRDNSSRFSLNGGANIEAIIASEKEVWNREK 3651
Query: 1445 TNLKERILILEMDIGKLKGE--NEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS 1502
L++ + E ++ KLK E N+ +++T ++E+ L+ K+ LR + F
Sbjct: 3652 LTLQKSLKRAEAEVYKLKAELRNDSLLQTL-SPDSEHVTLKRIYGKY---LRAESF---- 3703
Query: 1503 MKEKALAFEQ 1512
KAL +++
Sbjct: 3704 --RKALIYQK 3711
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 178 bits (452), Expect = 4e-44
Identities = 283/1248 (22%), Positives = 532/1248 (42%), Gaps = 194/1248 (15%)
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R+ + + +V R ++ + E+E+ + Q AE+ LK LE++ S L+
Sbjct: 836 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQK---AENELK------ELEQKHSQLT 886
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIA 495
+EK LQ L + L +E ++R+ L AK+QEL + + E E +
Sbjct: 887 EEKNLLQEQL--------------QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 932
Query: 496 EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITK 555
E E+ +Q Q K M L +Q E ++ KL+ + + ++ +LED+ +
Sbjct: 933 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEIL---- 988
Query: 556 ELDVQKEKLIQS----EVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKE 611
+D Q KL + E ++DL + E+K +NL NK ES +S + L+ +E
Sbjct: 989 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEE 1047
Query: 612 HIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL-EQLNENLKK 670
RQ E+L R L D+ S+F + + + +A++ LK L++ E+L L +
Sbjct: 1048 KSRQELEKLKR-------KLEGDA-SDFHEQ-IADLQAQIAELKMQLAKKEEELQAALAR 1098
Query: 671 VAFDVKMENEKLVLACE------DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAE 724
+ ++ +N L E D++ L+ A N+ +K + E L+ K E+E
Sbjct: 1099 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-- 1156
Query: 725 LCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ 784
L+++A Q E L K++ E+ LKK +++
Sbjct: 1157 -------------------------DTLDSTATQQE------LRAKREQEVTVLKKALDE 1185
Query: 785 MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEIL 844
H+ + ++E +Q K + +L E+L+++ +A +
Sbjct: 1186 ETRSHE-------AQVQEMRQ-------------KHAQAVEELTEQLEQFKRAKANLDKN 1225
Query: 845 RQTIEEKD-------RSLGSMKEENNHLQEELE-RLREEQSRTA--PVADPKTLDSVTEL 894
+QT+E+++ R LG K+E H +++LE +++E QS+ + A + D V +L
Sbjct: 1226 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1285
Query: 895 ASEVSQLNTIKEHLE-EEIKHHQKI--IEDQNQSKMQLLQSLQEQKKEMD-EFRYQHEQM 950
+EV + + E + IK + + + Q Q +LLQ QK + + R E+
Sbjct: 1286 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1345
Query: 951 NATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK 1010
N+ QL E+ E ++L++ I + QL + ++ +Q S + +E G ++
Sbjct: 1346 NSLQDQLD-EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA--------LEEGKKR 1396
Query: 1011 HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQL--SKDEVGKLTQIIQQKDLEI 1068
+ E E L + +E+ L + L +++D L D +L +++K +
Sbjct: 1397 F---QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1453
Query: 1069 QALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAA 1128
L A + S YA ER++ A EK + L + ++ A
Sbjct: 1454 DQLLAEEKNIS------------SKYADERDRAEAEAREKETKALSLARALEEALE---A 1498
Query: 1129 KEAALIKLQDENKKLSTRFES--SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186
KE +L+ NK L E S +D + + L + R + +++ + + + L
Sbjct: 1499 KE----ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 1187 LQTSSTGNEAGGVN----SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHE-SAQ 1241
LQ + VN QFE LQ RD+ ++ ++ +Q HE +
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ----------LQRQLHEYETE 1604
Query: 1242 LQEELHQ--LQAQVLVDSDNNSK-LQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
L++E Q L A + + K L++ I+ E+ +L+ ++ Q +
Sbjct: 1605 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1664
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQEL-EELRKSLQ 1357
++D + + S Q E L A +E + ++L ++EL EEL SL
Sbjct: 1665 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAA--AERARKQADLEKEELAEELASSLS 1722
Query: 1358 EKDATIRTLQENNHRLSDSIA-ATSELERKE---HEQTDSEIKQLKEKQDVLQKLLKEKD 1413
++A LQ+ RL IA ELE ++ +D K ++ + + +L E+
Sbjct: 1723 GRNA----LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1778
Query: 1414 LLIKAKS--DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVET 1471
K +S QL N+ +K++E E + K I LE I +L+ E++ +
Sbjct: 1779 TAQKNESARQQLERQNKELRSKLHEME--GAVKSKFKSTIAALEAKIAQLE---EQVEQE 1833
Query: 1472 YRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNA 1531
R K+ ++L++ + K +L + E E+ +A EQ ++ E+G + QL
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVE------DERKMA-EQYKEQAEKG-NARVKQLKRQ 1885
Query: 1532 VKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
++ +E++ R ++ L + N A+ EV L+ K R N+
Sbjct: 1886 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 177 bits (449), Expect = 9e-44
Identities = 259/1190 (21%), Positives = 502/1190 (42%), Gaps = 188/1190 (15%)
Query: 292 KTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECE 351
K +LQ+ + E ++M+ ED+++ ++ AEN+ L ++ QL EK + E+
Sbjct: 840 KVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ-- 895
Query: 352 NLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQA-LSDAENEIMRLSSLNQD 410
LQ ++ + R+ A+ +EE+ +A L + E+ +L + +
Sbjct: 896 --------LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA--ER 945
Query: 411 NSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI-----KSTATRDISL 465
+A+ L L+ ++E E + L EK + + KL +E V+ K + R + L
Sbjct: 946 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL-L 1004
Query: 466 DSELHDLRLNL---EAKEQELNQSISEKETLIAEI------EELDRQNQEATKHMI---- 512
+ + DL NL E K + L + ++ E++I+E+ EE RQ E K +
Sbjct: 1005 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1064
Query: 513 ---------------LIKDQLSKQQNEGDSIISKLKQDL---NDEKKRVHQLEDDKMDIT 554
+K QL+K++ E + +++L ++ N+ K++ +LE D+
Sbjct: 1065 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1124
Query: 555 KELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVD------QLNKSQESNVSIQKENLE 608
++LD ++ ++E DL + L+ ++E+ +D +L +E V++ K+ L+
Sbjct: 1125 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1184
Query: 609 LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENL 668
E R +E ++ +R + Q++ + + L++ + NL +N LE+ N +L
Sbjct: 1185 --EETRSHEAQVQEMRQKHAQAVEELTEQ------LEQFKRAKANLDKNKQTLEKENADL 1236
Query: 669 K---KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL 725
+V K E E E +L+ + + E N V L+ E + L
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1296
Query: 726 CWAKKRLLEEA-----------NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDME 774
A+ + ++ A + E EE N++T QLE E L + D E
Sbjct: 1297 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEE 1355
Query: 775 IAELKKNIE--------QMDTDHKETKDVLSS--SLEEQKQ--------LTQLINKKEIF 816
+ E K+N+E Q+ K+ +D S+ +LEE K+ LTQ +K
Sbjct: 1356 M-EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1414
Query: 817 IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQ 876
+KL++ ++LQ+ELD L L +E+K R + E ++ + R+
Sbjct: 1415 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1474
Query: 877 SRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQ 936
A + K L LA + + KE LE K + +ED SK + +++ E
Sbjct: 1475 EAEAREKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE- 1529
Query: 937 KKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQ-TDNSDIFQ 995
LEK + ++L+ +E++KTQL E ++Q T+++ +
Sbjct: 1530 ----------------------LEKSK--RALETQMEEMKTQLEELEDELQATEDAKLRL 1565
Query: 996 ETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG 1055
E +Q+L G + DL + + K R+L+ + L+E L + Q +
Sbjct: 1566 EVNMQAL---KGQFERDLQARDEQ---NEEKRRQLQ-RQLHEYETELEDERKQRALAAAA 1618
Query: 1056 KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME-------REKVFAVLNEK 1108
K KDLE+QA A + + LQ Q++ + E R+++FA E
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678
Query: 1109 TRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES--SGQDMFRETIQNLSRII 1166
++ L+ + ++ + +AA E A + E ++L+ S SG++ ++ + L I
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1738
Query: 1167 REKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQ 1226
+ + E++ + + S++ + Q+ ++L ++ Q
Sbjct: 1739 AQLEEELEEEQGNMEAM-----------------SDRVRKATQQAEQLSNELATERSTAQ 1781
Query: 1227 QVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQ 1286
+ + Q ++ ++ +L+ +LH+++ V SK + L Q E +++ +
Sbjct: 1782 KNESARQQLERQNKELRSKLHEMEGAV------KSKFKSTIAALEAKIAQLEEQVEQEAR 1835
Query: 1287 ELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQ 1346
E S+ Q KD KL I Q+ + Q E + V + L+
Sbjct: 1836 EKQAATKSLKQ----KD---KKLKEILLQVEDERKMAEQYKEQAEKGNARV-----KQLK 1883
Query: 1347 QELEELRKSLQEKDATIRTLQ-------ENNHRLSDSIAATSELERKEHE 1389
++LEE + Q +A R LQ E+N + + A R+ +E
Sbjct: 1884 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 177 bits (449), Expect = 9e-44
Identities = 247/1204 (20%), Positives = 511/1204 (42%), Gaps = 137/1204 (11%)
Query: 574 LHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ 633
L +T+Q E++++ D+L K++E QK ELKE + Q +L+ +N L + L
Sbjct: 845 LQVTRQ--EEEMQAKEDELQKTKERQ---QKAENELKE-LEQKHSQLTEEKNLLQEQLQA 898
Query: 634 DSNSNFKDTLLKER-EAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQ 692
++ + ++ R A+ + L++ L E+E E + ++ E +K+ D+ Q
Sbjct: 899 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 958
Query: 693 LEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNL 752
LEE A +L LEK T +K + EI + +L +E E+ I +L+
Sbjct: 959 LEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKLLEERISDLTT---- 1013
Query: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINK 812
N + + + ++L KL K + I+EL+ +++ + +E + + + + I
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 813 KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL 872
+ I +LK + +K +EEL AL + L I +K+ +L ++E H+ + E L
Sbjct: 1074 LQAQIAELKMQLAKKEEELQA---ALAR---LDDEIAQKNNALKKIRELEGHISDLQEDL 1127
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
E++ A K +L E+ L T E + Q++ + Q L ++
Sbjct: 1128 DSERA-----ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1182
Query: 933 LQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSD 992
L E+ + + Q ++M H Q E E+++ ++ K L + +Q ++ +N+D
Sbjct: 1183 LDEETRSHEA---QVQEMRQKHAQAVEELTEQLEQFKRA----KANLDKNKQTLEKENAD 1235
Query: 993 IFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD 1052
+ E +V + K +A+ + L + E LN+K L +++ ++
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1293
Query: 1053 EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN 1112
G L + A + +DV L QLQ +L E+TR+
Sbjct: 1294 --GMLNE-------------AEGKAIKLAKDVASLSSQLQ-------DTQELLQEETRQK 1331
Query: 1113 SHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIE 1172
++ T+ L +L++E L + + E QNL R I +I+
Sbjct: 1332 LNVSTK--------------LRQLEEERNSLQDQLDEE-----MEAKQNLERHISTLNIQ 1372
Query: 1173 IDALSQKCQTLLAVLQTSSTGNEAGGVN----SNQFEELLQERDKLKQQVKKMEEWKQQV 1228
+ +K Q + ++ G + + Q+EE DKL++ ++++ +
Sbjct: 1373 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1432
Query: 1229 MTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSY-EQNETKLKNFGQE 1287
+ + N + + L+++ + Q+L + N S D ++ + ETK + +
Sbjct: 1433 VVDLDNQRQLVSNLEKKQRKFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1491
Query: 1288 LAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQ 1347
L + + +L T +L +++ L S+ ++ L SK L E ++
Sbjct: 1492 LEEALEAKEELERTNKMLKAEME----DLVSSKDDVGKNVHELEKSK-RALETQMEEMKT 1546
Query: 1348 ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEI-KQLKEKQDVLQ 1406
+LEEL LQ + L+ N L + +++E+ ++ +QL E + L+
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1606
Query: 1407 KLLKEKDLLIKAKS-------DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG 1459
K++ L AK D L ++ + + LR+ +K+ + ++
Sbjct: 1607 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD----FQRELE 1662
Query: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQ 1519
+ ++I T + E + ++L+ M+ L E + K+ L E+L +E
Sbjct: 1663 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE---RARKQADLEKEELAEELAS 1719
Query: 1520 GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
+G NA+ Q E+ ++ + Q + E Q ++ + D+ ++ Q
Sbjct: 1720 SLSGR-----NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1764
Query: 1580 ELERLRNHLLES-----EDSYTREALAAEDRE--AKLRKKVTVLEEKLVSSSNAMENASH 1632
+ E+L N L ++ R+ L +++E +KL + ++ K S+ A+E
Sbjct: 1765 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE---- 1820
Query: 1633 QASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHF-QQEEKAMY 1691
++ L+EQ+ ++++ L +++K+ L + + + + E + +Q EK
Sbjct: 1821 ---AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG-- 1875
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
+A +++ K+ + E ++ ++ + LQ LDEA + ++ R L K L+
Sbjct: 1876 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK------LR 1929
Query: 1752 RQNE 1755
R NE
Sbjct: 1930 RGNE 1933
Score = 175 bits (444), Expect = 3e-43
Identities = 241/1142 (21%), Positives = 496/1142 (43%), Gaps = 134/1142 (11%)
Query: 180 EVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQ------------ 227
+V+R E E+ A+ + Q T Q K +N +KEL+Q SQ
Sbjct: 846 QVTRQEEEMQ-----AKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQL 896
Query: 228 ----EIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETD 283
E+ EM V A +Q+L EI L + E+R ++L+ ++ +++ +
Sbjct: 897 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 956
Query: 284 LSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEK 343
++ E + Q LQ+EKV + K+++LED+I ++ + + +R +L L
Sbjct: 957 -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1015
Query: 344 RQIMEECENLKLECSKLQPSAVKQSDTMTEKE-RILAQSASVEEVFRLQQAL----SDAE 398
+ E+ +NL +KL+ K ++E E R+ + S +E+ +L++ L SD
Sbjct: 1016 AEEEEKAKNL----TKLKN---KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1068
Query: 399 NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKST 458
+I L + +AE LKM+ L++++EELQ +L +L++E +
Sbjct: 1069 EQIADLQA-----QIAE----LKMQ----------LAKKEEELQAALARLDDEIAQKNNA 1109
Query: 459 ATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQL 518
+ L+ + DL+ +L+++ N++ +K L E+E L + ++ ++
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1169
Query: 519 SKQQNEGDSIISKLKQDLNDEKKRVH--QLEDDKMDITKELDVQKEKLIQSEVALNDLHL 576
+K++ E ++ LK+ L DE+ R H Q+++ + + ++ E+L Q + A +L
Sbjct: 1170 AKREQE----VTVLKKAL-DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
Query: 577 TKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS---RIRNELMQSLNQ 633
KQ LE + +L +L ++ ++ + +L+ +++ + + S R R EL +++
Sbjct: 1225 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1284
Query: 634 DSNSNFKDT-LLKEREA-------EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685
N T +L E E +V +L L + ++L + + +V + +L
Sbjct: 1285 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1344
Query: 686 CEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEE 745
++ QL+E + L +T+ L K +++ + + L E +++K IE
Sbjct: 1345 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIEN 1403
Query: 746 LSNARNLNTSA----------LQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDV 795
L+ +A LQ E + L+ + ++ L+K + D E K++
Sbjct: 1404 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1463
Query: 796 LSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSL 855
S +E+ + +KE K + L+E L+ + R N++L+ +E+ L
Sbjct: 1464 SSKYADERDRAEAEAREKE---TKALSLARALEEALEAKEELERTNKMLKAEMED----L 1516
Query: 856 GSMKEE---NNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
S K++ N H E+ +R E Q + D + +L + L+ +
Sbjct: 1517 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1576
Query: 913 KHHQKIIEDQNQSK-MQLLQSLQEQKKEMDEFRYQH-------EQMNATHTQLFLEKDEE 964
+ + ++QN+ K QL + L E + E+++ R Q +++ L L+ D
Sbjct: 1577 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1636
Query: 965 IKSLQKTIEQIK------TQLHEERQDIQTDNSDIF-----QETKVQSLNIENGSEKHDL 1013
IK ++ I+Q++ E +D + +IF E K +SL + + DL
Sbjct: 1637 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1696
Query: 1014 SKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD-EVGKLTQIIQQKDLEIQALH 1072
+ AE R +++ EL +L + + Q ++ + + +L + ++++ ++A+
Sbjct: 1697 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1756
Query: 1073 ARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAK-EA 1131
R+ TQ L +L +K + + R+N L+++ H+M V +K ++
Sbjct: 1757 DRVRKA--TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1814
Query: 1132 ALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSS 1191
+ L+ + +L + E REK +L QK + L +L
Sbjct: 1815 TIAALEAKIAQLEEQVEQEA---------------REKQAATKSLKQKDKKLKEILLQVE 1859
Query: 1192 TGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA 1251
+ Q E+ +LK+Q+++ EE Q++ + +Q E + E +
Sbjct: 1860 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1919
Query: 1252 QV 1253
+V
Sbjct: 1920 EV 1921
Score = 162 bits (409), Expect = 4e-39
Identities = 258/1201 (21%), Positives = 510/1201 (42%), Gaps = 186/1201 (15%)
Query: 76 TDLEEKHEASEIQI---KQQSTSYRNQLQQKEVEISHLKARQIALQDQL---LKLQSAAQ 129
T EE+ +A E ++ K++ N+L++ E + S L + LQ+QL +L + A+
Sbjct: 848 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 907
Query: 130 SVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVG 189
+ A I H A +++ D G + Q E +++ ++ LE ++
Sbjct: 908 EMR-----VRLAAKKQELEEILHEMEARLEEEEDRGQQL--QAERKKMAQQMLDLEEQLE 960
Query: 190 HWRHIAQ-------TSKAQ------------GTDNSDQSEICKLQNIIKELKQNRSQEID 230
Q T++A+ +N E L+ I +L N ++E +
Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-E 1019
Query: 231 DHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM 290
+ ++ L+N H+ ++E+ R ++E E+ +ELE L ++ +E D S +E
Sbjct: 1020 EKAKNLTKLKNKHESMISELEVRLKKE----EKSRQELEKLKRK-----LEGDASDFHEQ 1070
Query: 291 QKTIQVLQIE-KVESTKKMEQLE-----------------DKIKDINKKLSSAENDRDIL 332
+Q E K++ KK E+L+ KI+++ +S + D D
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130
Query: 333 RREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQ 392
R + + +KR + EE E LK E S Q + ++E +EV L++
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---------QEVTVLKK 1181
Query: 393 AL-SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNE 451
AL + + ++ + Q ++ A + +L ++E ++ K+ L + K+ L+ L E
Sbjct: 1182 ALDEETRSHEAQVQEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1239
Query: 452 YEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHM 511
V+ E+ + LEA+ QEL S+ E AE
Sbjct: 1240 LRVLGQA-------KQEVEHKKKKLEAQVQELQSKCSDGERARAE--------------- 1277
Query: 512 ILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVAL 571
+ D++ K QNE +S+ LN+ + + +L D ++ +L +E L +
Sbjct: 1278 --LNDKVHKLQNEVESVTGM----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1331
Query: 572 NDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSL 631
++ ++LE++ +L DQL++ E+ K+NLE HI +LS + +L
Sbjct: 1332 LNVSTKLRQLEEERNSLQDQLDEEMEA-----KQNLE--RHISTLNIQLSDSKKKL---- 1380
Query: 632 NQDSNSNFK--DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDV 689
QD S + + K + E+ NL Q E + L+K ++ E + LV+ ++
Sbjct: 1381 -QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1439
Query: 690 RH---QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEEL 746
R LE+ +QL E+ I E+ EAE + + L A E+ +E
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499
Query: 747 SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL 806
N L+ E E L+ + EL+K+ ++T +E K L LE++ Q
Sbjct: 1500 EELERTN-KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQA 1557
Query: 807 TQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ 866
T+ +KL+ E++ + + L+ E+ + ++ + + +
Sbjct: 1558 TE---------------DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1602
Query: 867 EELERLREEQSRTAPV-----ADPKTLDSVTELASEVSQLNTIKE--HLEEEIKHHQKII 919
ELE R++++ A D K L+ + A + + IK+ L+ ++K Q+ +
Sbjct: 1603 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQREL 1661
Query: 920 EDQNQSKMQLLQSLQEQKK-----EMDEFRYQHEQMNA--THTQLFLEKDEEIKSLQKTI 972
ED S+ ++ + +E +K E D + Q + A Q LEK+E + L ++
Sbjct: 1662 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1721
Query: 973 EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEI 1032
+ L +E++ ++ + + +E + + N+E S++ + + E+L +
Sbjct: 1722 SG-RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE---- 1776
Query: 1033 KLLNEKNISLTKQIDQLSKDEVGKLTQI---IQQK-DLEIQALHARISSTSHTQDVVYLQ 1088
+ +KN S +Q+++ +K+ KL ++ ++ K I AL A+I+ L+
Sbjct: 1777 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ---------LE 1827
Query: 1089 QQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFE 1148
+Q++ A E++ L +K + K+ +I L++++DE K E
Sbjct: 1828 EQVEQEAREKQAATKSLKQKDK----------KLKEI-------LLQVEDERKMAEQYKE 1870
Query: 1149 SSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELL 1208
+ + R ++ L R + E + E ++ + L L ++ NEA G N + L
Sbjct: 1871 QAEKGNAR--VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1928
Query: 1209 Q 1209
+
Sbjct: 1929 R 1929
Score = 151 bits (381), Expect = 7e-36
Identities = 218/1060 (20%), Positives = 434/1060 (40%), Gaps = 142/1060 (13%)
Query: 757 LQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL--------TQ 808
+Q + + L K +++ ELK+ +EQ + E K++L L+ + +L +
Sbjct: 854 MQAKEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 912
Query: 809 LINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
L KK+ E L E ++L+EE D+ Q + + + Q + + + L EE
Sbjct: 913 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-----------EE 961
Query: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQ 928
E R++ A+ K + +L E+ ++ L +E +K++E++
Sbjct: 962 EEAARQKLQLEKVTAEAK----IKKLEDEILVMDDQNNKLSKE----RKLLEERISDLTT 1013
Query: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE----EIKSLQKTIEQIKTQLHEERQ 984
L +E+ K + + + +HE M + ++ L+K+E E++ L++ +E + HE+
Sbjct: 1014 NLAEEEEKAKNLTKLKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1072
Query: 985 DIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTK 1044
D+Q +++ + + ++ + D A+ +K I+E E I L E
Sbjct: 1073 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE------- 1125
Query: 1045 QIDQLSKDEVGKLTQIIQQKDL--EIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVF 1102
L + + Q++DL E++AL + T D QQ+L+A + V
Sbjct: 1126 ---DLDSERAARNKAEKQKRDLGEELEALKTELEDTL---DSTATQQELRAKREQEVTVL 1179
Query: 1103 A-VLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--I 1159
L+E+TR + + + +M A L + ++ K+ + + Q + +E +
Sbjct: 1180 KKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1236
Query: 1160 QNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVK 1219
R++ + E++ +K + + LQ+ + E N LQ ++++
Sbjct: 1237 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ--NEVESVTG 1294
Query: 1220 KMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNET 1279
+ E + + + +++ S+QLQ+ Q L+ + KL V T
Sbjct: 1295 MLNEAEGKAIKLAKDVASLSSQLQD------TQELLQEETRQKLNVS------------T 1336
Query: 1280 KLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLS 1339
KL+ +E +Q + + K L + ++ QLS + A S E L
Sbjct: 1337 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA-----STVEALE 1391
Query: 1340 ESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK 1399
E + Q+E+E L + +EK A L++ +RL ++ D + L
Sbjct: 1392 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ--------------QELDDLVVDLD 1437
Query: 1400 EKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG 1459
++ ++ L K++ K DQLL+ +N ++K + +A KE
Sbjct: 1438 NQRQLVSNLEKKQ-----RKFDQLLAEEKNISSKYADERDRAEAEAREKET--------- 1483
Query: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQ 1519
K + R E +A +E M+ E E S + +L K K
Sbjct: 1484 -------KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1536
Query: 1520 GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
+T ++ ++ ++ ++++ Q D + Q + ++Q ++ +
Sbjct: 1537 LET-QMEEMKTQLEELEDE---LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1592
Query: 1580 ELER-LRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQA---S 1635
+L+R L + E ED + ALAA ++ KL + LE + S+ E A Q
Sbjct: 1593 QLQRQLHEYETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1651
Query: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAEL 1695
Q++ Q +L RDE ++++ K L LQ E E+A A+L
Sbjct: 1652 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ---EDLAAAERARKQADL 1708
Query: 1696 EKQK---QLIAEWK-KNA-----ENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ 1746
EK++ +L + +NA LE ++ L+E L+E +++ S + + EQ
Sbjct: 1709 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1768
Query: 1747 IEE-------LKRQNELRQEMLDDVQKKLMSLANSSEGKV 1779
+ ++NE ++ L+ K+L S + EG V
Sbjct: 1769 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1808
Score = 129 bits (324), Expect = 3e-29
Identities = 201/945 (21%), Positives = 392/945 (41%), Gaps = 160/945 (16%)
Query: 64 LRSENERLKKLCTDLEEKHEAS----EIQIKQQSTSYRN--QLQQK-EVEISHLKARQIA 116
L E E+ K L T L+ KHE+ E+++K++ S + +L++K E + S +
Sbjct: 1015 LAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1073
Query: 117 LQDQL--LKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEI 174
LQ Q+ LK+Q A + A + D + ++ ++I
Sbjct: 1074 LQAQIAELKMQLAKKEEELQAALARL--------------------DDEIAQKNNALKKI 1113
Query: 175 NRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICK--LQNII------KELKQNRS 226
L +S L+ ++ R ++ Q D ++ E K L++ + +EL+ R
Sbjct: 1114 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1173
Query: 227 QEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSK 286
QE+ + + +H+ ++ E+ ++H + + + E++E+ + +T +
Sbjct: 1174 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKE 1232
Query: 287 IYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQI 346
++ ++VL K E K ++LE +++++ K S E R L + +L E +
Sbjct: 1233 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1292
Query: 347 MEECENLKLECSKLQPSAVKQSDTMTEKERILAQ--------SASVEEVFRLQQALSDAE 398
+ + KL S + + + +L + S + ++ + +L D
Sbjct: 1293 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1352
Query: 399 NEIMR--------LSSLNQDNSLAEDNLK-LKMRIEVLEKEKSLLSQEKEELQMSLLKLN 449
+E M +S+LN S ++ L+ +E LE+ K +E E L +
Sbjct: 1353 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1412
Query: 450 NEYEVIKSTATRDISLDSELHDLRL----------NLEAKEQELNQSISEKETLIAEI-E 498
Y+ ++ T R L EL DL + NLE K+++ +Q ++E++ + ++ +
Sbjct: 1413 AAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1469
Query: 499 ELDRQNQEA----TKHMILI---------KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQ 545
E DR EA TK + L K++L + + + L +D K VH+
Sbjct: 1470 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1529
Query: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKS-QESNVSIQK 604
LE K + +++ K +L + E L K +LE ++ L Q + Q + ++
Sbjct: 1530 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1589
Query: 605 ENLELKEHIRQNEEELSRIRNE--LMQSLNQDSNSNFKD------TLLKEREAEVRNLKQ 656
+ +L+ + + E EL R + L + + + KD + +K RE ++ L++
Sbjct: 1590 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1649
Query: 657 NLSELEQLNENLKKVA------FDVKMENEKLVLACEDVRHQLEECLAG----NNQLSLE 706
++++ L+ F ENEK + E QL+E LA Q LE
Sbjct: 1650 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1709
Query: 707 KNTIVE----------TLKMEKGEIEAELCWAKKRLLEEANKYE----------KTIEEL 746
K + E L+ EK +EA + ++ L EE E + E+L
Sbjct: 1710 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1769
Query: 747 SN--------ARNLNTSALQLEHEHLIKLNQKKDME-----------------IAELKKN 781
SN A+ ++ QLE ++ ++ +ME IA+L++
Sbjct: 1770 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1829
Query: 782 IEQ-----------MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
+EQ + K+ K++L +E+K Q + E ++K+ +L EE
Sbjct: 1830 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EE 1888
Query: 831 LDKYSQALRKNEI-LRQTIEEKDRSLGSMKEENNHLQEELERLRE 874
++ SQ + N L++ ++E S +M E N L+ +L R E
Sbjct: 1889 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1933
Score = 119 bits (297), Expect = 4e-26
Identities = 227/1059 (21%), Positives = 426/1059 (40%), Gaps = 174/1059 (16%)
Query: 741 KTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSL 800
K +E N + S + L L +++D++I ++ + M + K +
Sbjct: 752 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARK----AFA 807
Query: 801 EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKE 860
+ Q+QLT + + LK R+ + K L ++ RQ +E
Sbjct: 808 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL---QVTRQ------------EE 852
Query: 861 ENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE 920
E ++EL++ +E Q K + + EL + SQL K L+E+++ ++
Sbjct: 853 EMQAKEDELQKTKERQQ--------KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 904
Query: 921 DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH 980
+ + +++L QE ++ + E + E+ QL E+ K + + + ++ QL
Sbjct: 905 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLE 960
Query: 981 EERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL--EIKLLNEK 1038
EE E Q L +E + + + K E E LV + +L E KLL E+
Sbjct: 961 EE-------------EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1007
Query: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHT-QDVVYLQQQLQAYAME 1097
LT + + +++ LT++ + + I L R+ + Q++ L+++L+ A +
Sbjct: 1008 ISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1066
Query: 1098 REKVFAVLNEKTRE--------NSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+ A L + E L+ ++ D +A K AL K+++ +S E
Sbjct: 1067 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1126
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
D R + R+ E++AL + + L ST + +EL
Sbjct: 1127 L--DSERAARNKAEKQKRDLGEELEALKTELEDTL-----DSTATQ---------QELRA 1170
Query: 1210 ERDKLKQQVKK-MEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYT 1268
+R++ +KK ++E + VQ M+ + AQ EEL + Q +K +D
Sbjct: 1171 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF-----KRAKANLD-- 1223
Query: 1269 GLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAE 1328
+N+ L+ +LA +GQ + KL+ +L S E
Sbjct: 1224 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC----SDGE 1272
Query: 1329 CLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1388
RA L++ LQ E+E + L E + L ++ LS + T EL ++E
Sbjct: 1273 RARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1328
Query: 1389 EQ---TDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVT 1445
Q ++++QL+E+++ LQ L E+ +A
Sbjct: 1329 RQKLNVSTKLRQLEEERNSLQDQLDEE----------------------------MEAKQ 1360
Query: 1446 NLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKE 1505
NL+ I L + + K + + T +AL+E +F +E E +E
Sbjct: 1361 NLERHISTLNIQLSDSKKKLQDFASTV-------EALEEGKKRFQ---KEIENLTQQYEE 1410
Query: 1506 KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565
KA A+++L K K N ++ + VV + Q++ L++KQ + L
Sbjct: 1411 KAAAYDKLEKTK------------NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1458
Query: 1566 EVQRLRDK--EFRSNQELE-RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVS 1622
E + + K + R E E R + S EAL A++ + K + E LVS
Sbjct: 1459 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1518
Query: 1623 SSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEH 1682
S + + H+ +L+ Q+ + Q +E +L +++ + +++ L+ E
Sbjct: 1519 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1578
Query: 1683 ------FQQEEKAM--------YSAELE---KQKQLIAEWKKNAENLEGKVISLQECLDE 1725
Q EEK Y ELE KQ+ L A KK LEG + L+ +
Sbjct: 1579 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK---KLEGDLKDLEL---Q 1632
Query: 1726 ANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDV 1764
A++A+ +QL + Q+++ +R+ E + D++
Sbjct: 1633 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1671
Score = 105 bits (262), Expect = 4e-22
Identities = 168/769 (21%), Positives = 319/769 (41%), Gaps = 102/769 (13%)
Query: 1055 GKLTQIIQQKDLEI----QALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110
G L + +++DL+I A A + QQQL A + + A L +
Sbjct: 773 GVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNW 832
Query: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKD 1170
+ L T+ ++ + +E K +DE +K R + ++ +E Q S++ EK+
Sbjct: 833 QWWRLFTKVKPLLQVTRQEEEMQAK-EDELQKTKER-QQKAENELKELEQKHSQLTEEKN 890
Query: 1171 I---------EIDA--------LSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDK 1213
+ E+ A L+ K Q L +L E ++ ++L ER K
Sbjct: 891 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE---EEDRGQQLQAERKK 947
Query: 1214 LKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS 1273
+ QQ+ +EE ++ Q +Q E + ++ +L+ ++LV D N+KL + L
Sbjct: 948 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL--- 1004
Query: 1274 YEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRAS 1333
E ++ + LA+ + L K+ S++ S
Sbjct: 1005 ----EERISDLTTNLAEEEEKAKNLTKLKN-------------KHESMI----------S 1037
Query: 1334 KSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDS 1393
+ EV + E +QELE+L++ L E DA+ + + +++D A +EL+
Sbjct: 1038 ELEVRLKKEEKSRQELEKLKRKL-EGDAS-----DFHEQIADLQAQIAELKM-------- 1083
Query: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQL--LSSNENFTNKVNENELLRQAVTNLKERI 1451
QL +K++ LQ L D I K++ L + E + + E+ +A N E+
Sbjct: 1084 ---QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK- 1139
Query: 1452 LILEMDIGK----LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS----- 1502
+ D+G+ LK E E +++ + E +A +E + ++E H
Sbjct: 1140 --QKRDLGEELEALKTELEDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1196
Query: 1503 MKEK-ALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENT 1561
M++K A A E+L ++ EQ K + N N ++++++ E + A ++ + +
Sbjct: 1197 MRQKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQAKQEVEHKKK 1255
Query: 1562 ALQNEVQRLRDK---EFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEE 1618
L+ +VQ L+ K R+ EL + L +S T AE + KL K V L
Sbjct: 1256 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1315
Query: 1619 KLVSSSNAMENASHQ---ASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLAN 1675
+L + ++ + Q S ++ L+E+ N + Q DE + + + L++
Sbjct: 1316 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1375
Query: 1676 LQMVLEHFQ------QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAA 1729
+ L+ F +E K + E+E Q E + LE LQ+ LD+
Sbjct: 1376 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1435
Query: 1730 LDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGK 1778
LD+ +L L+ K+ + ++L + + D + + + A E K
Sbjct: 1436 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1484
Score = 66.2 bits (160), Expect = 3e-10
Identities = 94/472 (19%), Positives = 196/472 (41%), Gaps = 72/472 (15%)
Query: 1367 QENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL---IKAKSDQL 1423
+E D + T E ++K ++E+K+L++K +L +EK+LL ++A+++
Sbjct: 851 EEEMQAKEDELQKTKERQQK----AENELKELEQKHS---QLTEEKNLLQEQLQAETELY 903
Query: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQ 1483
+ E + + L + + ++ R+ E +L+ E +K+ + E + + +
Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963
Query: 1484 ETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQ 1543
K + E K K L E L+ + + K + +LL S + +
Sbjct: 964 AARQKLQL-----EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1018
Query: 1544 QERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALA-- 1601
+E+ + + LK K + ++ +E++ KE +S QELE+L+ LE + S E +A
Sbjct: 1019 EEKAKNLTKLKNK---HESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADL 1074
Query: 1602 ----------AEDREAKLRKKVTVLEEKLVSSSNAMEN--------------------AS 1631
+E +L+ + L++++ +NA++ A
Sbjct: 1075 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1134
Query: 1632 HQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMY 1691
++A Q L E+L + + ++T + QE + + L+ L+ + +A
Sbjct: 1135 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1194
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISL---QECLDEANAALDSASRLTEQLDVK----- 1743
+K Q + E + E + +L ++ L++ NA L R+ Q +
Sbjct: 1195 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 1744 ---EEQIEELKRQ----NELRQEMLDDVQK------KLMSLANSSEGKVDKV 1782
E Q++EL+ + R E+ D V K + + N +EGK K+
Sbjct: 1255 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1306
Score = 47.8 bits (112), Expect = 1e-04
Identities = 65/349 (18%), Positives = 128/349 (36%), Gaps = 23/349 (6%)
Query: 38 LMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYR 97
L E E EL D R + A A + E + LK L + + E IKQ +
Sbjct: 1594 LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR---K 1649
Query: 98 NQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAF 157
Q Q K+ + AR A +D++ + A A
Sbjct: 1650 LQAQMKDFQRELEDAR--ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1707
Query: 158 HDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNI 217
+ + ++ SS N L +E RLE+ + + + QG + + K
Sbjct: 1708 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRKATQQ 1765
Query: 218 IKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGS 277
++L + E Q S Q +Q + ++ E+E ++
Sbjct: 1766 AEQLSNELATERSTAQKNESARQQLERQN------------KELRSKLHEMEGAVKSKFK 1813
Query: 278 GVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQE 337
I +KI ++++ ++ EK +TK ++Q + K+K+I ++ + + + E
Sbjct: 1814 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1873
Query: 338 QLNVEKRQIMEECENLKLECSKLQPSAVK---QSDTMTEKERILAQSAS 383
+ N +Q+ + E + E ++ + K + D TE + + +
Sbjct: 1874 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1922
Score = 38.1 bits (87), Expect = 0.086
Identities = 35/148 (23%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ-QEEKAMYSAE 1694
+QV +E++ Q E LQ + ++Q + L ++ +H Q EEK + +
Sbjct: 845 LQVTRQEEEM-----QAKEDELQKTKERQQKAENELK----ELEQKHSQLTEEKNLLQEQ 895
Query: 1695 LEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQN 1754
L+ + +L AE ++ L K L+E L E A L+ +QL + +++ +
Sbjct: 896 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 955
Query: 1755 ELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
E + E + ++KL ++E K+ K+
Sbjct: 956 EEQLEEEEAARQKLQLEKVTAEAKIKKL 983
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 178 bits (452), Expect = 4e-44
Identities = 283/1248 (22%), Positives = 532/1248 (42%), Gaps = 194/1248 (15%)
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R+ + + +V R ++ + E+E+ + Q AE+ LK LE++ S L+
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQK---AENELK------ELEQKHSQLT 893
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIA 495
+EK LQ L + L +E ++R+ L AK+QEL + + E E +
Sbjct: 894 EEKNLLQEQL--------------QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939
Query: 496 EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITK 555
E E+ +Q Q K M L +Q E ++ KL+ + + ++ +LED+ +
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEIL---- 995
Query: 556 ELDVQKEKLIQS----EVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKE 611
+D Q KL + E ++DL + E+K +NL NK ES +S + L+ +E
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEE 1054
Query: 612 HIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL-EQLNENLKK 670
RQ E+L R L D+ S+F + + + +A++ LK L++ E+L L +
Sbjct: 1055 KSRQELEKLKR-------KLEGDA-SDFHEQ-IADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 671 VAFDVKMENEKLVLACE------DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAE 724
+ ++ +N L E D++ L+ A N+ +K + E L+ K E+E
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-- 1163
Query: 725 LCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ 784
L+++A Q E L K++ E+ LKK +++
Sbjct: 1164 -------------------------DTLDSTATQQE------LRAKREQEVTVLKKALDE 1192
Query: 785 MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEIL 844
H+ + ++E +Q K + +L E+L+++ +A +
Sbjct: 1193 ETRSHE-------AQVQEMRQ-------------KHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 845 RQTIEEKD-------RSLGSMKEENNHLQEELE-RLREEQSRTA--PVADPKTLDSVTEL 894
+QT+E+++ R LG K+E H +++LE +++E QS+ + A + D V +L
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 895 ASEVSQLNTIKEHLE-EEIKHHQKI--IEDQNQSKMQLLQSLQEQKKEMD-EFRYQHEQM 950
+EV + + E + IK + + + Q Q +LLQ QK + + R E+
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 951 NATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK 1010
N+ QL E+ E ++L++ I + QL + ++ +Q S + +E G ++
Sbjct: 1353 NSLQDQLD-EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA--------LEEGKKR 1403
Query: 1011 HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQL--SKDEVGKLTQIIQQKDLEI 1068
+ E E L + +E+ L + L +++D L D +L +++K +
Sbjct: 1404 F---QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 1069 QALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAA 1128
L A + S YA ER++ A EK + L + ++ A
Sbjct: 1461 DQLLAEEKNIS------------SKYADERDRAEAEAREKETKALSLARALEEALE---A 1505
Query: 1129 KEAALIKLQDENKKLSTRFES--SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186
KE +L+ NK L E S +D + + L + R + +++ + + + L
Sbjct: 1506 KE----ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 1187 LQTSSTGNEAGGVN----SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHE-SAQ 1241
LQ + VN QFE LQ RD+ ++ ++ +Q HE +
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ----------LQRQLHEYETE 1611
Query: 1242 LQEELHQ--LQAQVLVDSDNNSK-LQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
L++E Q L A + + K L++ I+ E+ +L+ ++ Q +
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQEL-EELRKSLQ 1357
++D + + S Q E L A +E + ++L ++EL EEL SL
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAA--AERARKQADLEKEELAEELASSLS 1729
Query: 1358 EKDATIRTLQENNHRLSDSIA-ATSELERKE---HEQTDSEIKQLKEKQDVLQKLLKEKD 1413
++A LQ+ RL IA ELE ++ +D K ++ + + +L E+
Sbjct: 1730 GRNA----LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 1414 LLIKAKS--DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVET 1471
K +S QL N+ +K++E E + K I LE I +L+ E++ +
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEME--GAVKSKFKSTIAALEAKIAQLE---EQVEQE 1840
Query: 1472 YRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNA 1531
R K+ ++L++ + K +L + E E+ +A EQ ++ E+G + QL
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVE------DERKMA-EQYKEQAEKG-NARVKQLKRQ 1892
Query: 1532 VKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
++ +E++ R ++ L + N A+ EV L+ K R N+
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 177 bits (449), Expect = 9e-44
Identities = 259/1190 (21%), Positives = 502/1190 (42%), Gaps = 188/1190 (15%)
Query: 292 KTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECE 351
K +LQ+ + E ++M+ ED+++ ++ AEN+ L ++ QL EK + E+
Sbjct: 847 KVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ-- 902
Query: 352 NLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQA-LSDAENEIMRLSSLNQD 410
LQ ++ + R+ A+ +EE+ +A L + E+ +L + +
Sbjct: 903 --------LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA--ER 952
Query: 411 NSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI-----KSTATRDISL 465
+A+ L L+ ++E E + L EK + + KL +E V+ K + R + L
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL-L 1011
Query: 466 DSELHDLRLNL---EAKEQELNQSISEKETLIAEI------EELDRQNQEATKHMI---- 512
+ + DL NL E K + L + ++ E++I+E+ EE RQ E K +
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 513 ---------------LIKDQLSKQQNEGDSIISKLKQDL---NDEKKRVHQLEDDKMDIT 554
+K QL+K++ E + +++L ++ N+ K++ +LE D+
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 555 KELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVD------QLNKSQESNVSIQKENLE 608
++LD ++ ++E DL + L+ ++E+ +D +L +E V++ K+ L+
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 609 LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENL 668
E R +E ++ +R + Q++ + + L++ + NL +N LE+ N +L
Sbjct: 1192 --EETRSHEAQVQEMRQKHAQAVEELTEQ------LEQFKRAKANLDKNKQTLEKENADL 1243
Query: 669 K---KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL 725
+V K E E E +L+ + + E N V L+ E + L
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 726 CWAKKRLLEEA-----------NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDME 774
A+ + ++ A + E EE N++T QLE E L + D E
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEE 1362
Query: 775 IAELKKNIE--------QMDTDHKETKDVLSS--SLEEQKQ--------LTQLINKKEIF 816
+ E K+N+E Q+ K+ +D S+ +LEE K+ LTQ +K
Sbjct: 1363 M-EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 817 IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQ 876
+KL++ ++LQ+ELD L L +E+K R + E ++ + R+
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 877 SRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQ 936
A + K L LA + + KE LE K + +ED SK + +++ E
Sbjct: 1482 EAEAREKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE- 1536
Query: 937 KKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQ-TDNSDIFQ 995
LEK + ++L+ +E++KTQL E ++Q T+++ +
Sbjct: 1537 ----------------------LEKSK--RALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 996 ETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG 1055
E +Q+L G + DL + + K R+L+ + L+E L + Q +
Sbjct: 1573 EVNMQAL---KGQFERDLQARDEQ---NEEKRRQLQ-RQLHEYETELEDERKQRALAAAA 1625
Query: 1056 KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME-------REKVFAVLNEK 1108
K KDLE+QA A + + LQ Q++ + E R+++FA E
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 1109 TRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES--SGQDMFRETIQNLSRII 1166
++ L+ + ++ + +AA E A + E ++L+ S SG++ ++ + L I
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 1167 REKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQ 1226
+ + E++ + + S++ + Q+ ++L ++ Q
Sbjct: 1746 AQLEEELEEEQGNMEAM-----------------SDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 1227 QVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQ 1286
+ + Q ++ ++ +L+ +LH+++ V SK + L Q E +++ +
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAV------KSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 1287 ELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQ 1346
E S+ Q KD KL I Q+ + Q E + V + L+
Sbjct: 1843 EKQAATKSLKQ----KD---KKLKEILLQVEDERKMAEQYKEQAEKGNARV-----KQLK 1890
Query: 1347 QELEELRKSLQEKDATIRTLQ-------ENNHRLSDSIAATSELERKEHE 1389
++LEE + Q +A R LQ E+N + + A R+ +E
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 177 bits (449), Expect = 9e-44
Identities = 247/1204 (20%), Positives = 511/1204 (42%), Gaps = 137/1204 (11%)
Query: 574 LHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ 633
L +T+Q E++++ D+L K++E QK ELKE + Q +L+ +N L + L
Sbjct: 852 LQVTRQ--EEEMQAKEDELQKTKERQ---QKAENELKE-LEQKHSQLTEEKNLLQEQLQA 905
Query: 634 DSNSNFKDTLLKER-EAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQ 692
++ + ++ R A+ + L++ L E+E E + ++ E +K+ D+ Q
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 693 LEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNL 752
LEE A +L LEK T +K + EI + +L +E E+ I +L+
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKLLEERISDLTT---- 1020
Query: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINK 812
N + + + ++L KL K + I+EL+ +++ + +E + + + + I
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 813 KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL 872
+ I +LK + +K +EEL AL + L I +K+ +L ++E H+ + E L
Sbjct: 1081 LQAQIAELKMQLAKKEEELQA---ALAR---LDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
E++ A K +L E+ L T E + Q++ + Q L ++
Sbjct: 1135 DSERA-----ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 933 LQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSD 992
L E+ + + Q ++M H Q E E+++ ++ K L + +Q ++ +N+D
Sbjct: 1190 LDEETRSHEA---QVQEMRQKHAQAVEELTEQLEQFKRA----KANLDKNKQTLEKENAD 1242
Query: 993 IFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD 1052
+ E +V + K +A+ + L + E LN+K L +++ ++
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1300
Query: 1053 EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN 1112
G L + A + +DV L QLQ +L E+TR+
Sbjct: 1301 --GMLNE-------------AEGKAIKLAKDVASLSSQLQ-------DTQELLQEETRQK 1338
Query: 1113 SHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIE 1172
++ T+ L +L++E L + + E QNL R I +I+
Sbjct: 1339 LNVSTK--------------LRQLEEERNSLQDQLDEE-----MEAKQNLERHISTLNIQ 1379
Query: 1173 IDALSQKCQTLLAVLQTSSTGNEAGGVN----SNQFEELLQERDKLKQQVKKMEEWKQQV 1228
+ +K Q + ++ G + + Q+EE DKL++ ++++ +
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 1229 MTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSY-EQNETKLKNFGQE 1287
+ + N + + L+++ + Q+L + N S D ++ + ETK + +
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 1288 LAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQ 1347
L + + +L T +L +++ L S+ ++ L SK L E ++
Sbjct: 1499 LEEALEAKEELERTNKMLKAEME----DLVSSKDDVGKNVHELEKSK-RALETQMEEMKT 1553
Query: 1348 ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEI-KQLKEKQDVLQ 1406
+LEEL LQ + L+ N L + +++E+ ++ +QL E + L+
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 1407 KLLKEKDLLIKAKS-------DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG 1459
K++ L AK D L ++ + + LR+ +K+ + ++
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD----FQRELE 1669
Query: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQ 1519
+ ++I T + E + ++L+ M+ L E + K+ L E+L +E
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE---RARKQADLEKEELAEELAS 1726
Query: 1520 GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
+G NA+ Q E+ ++ + Q + E Q ++ + D+ ++ Q
Sbjct: 1727 SLSGR-----NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 1580 ELERLRNHLLES-----EDSYTREALAAEDRE--AKLRKKVTVLEEKLVSSSNAMENASH 1632
+ E+L N L ++ R+ L +++E +KL + ++ K S+ A+E
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE---- 1827
Query: 1633 QASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHF-QQEEKAMY 1691
++ L+EQ+ ++++ L +++K+ L + + + + E + +Q EK
Sbjct: 1828 ---AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG-- 1882
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
+A +++ K+ + E ++ ++ + LQ LDEA + ++ R L K L+
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK------LR 1936
Query: 1752 RQNE 1755
R NE
Sbjct: 1937 RGNE 1940
Score = 175 bits (444), Expect = 3e-43
Identities = 241/1142 (21%), Positives = 496/1142 (43%), Gaps = 134/1142 (11%)
Query: 180 EVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQ------------ 227
+V+R E E+ A+ + Q T Q K +N +KEL+Q SQ
Sbjct: 853 QVTRQEEEMQ-----AKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQL 903
Query: 228 ----EIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETD 283
E+ EM V A +Q+L EI L + E+R ++L+ ++ +++ +
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 284 LSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEK 343
++ E + Q LQ+EKV + K+++LED+I ++ + + +R +L L
Sbjct: 964 -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 344 RQIMEECENLKLECSKLQPSAVKQSDTMTEKE-RILAQSASVEEVFRLQQAL----SDAE 398
+ E+ +NL +KL+ K ++E E R+ + S +E+ +L++ L SD
Sbjct: 1023 AEEEEKAKNL----TKLKN---KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 399 NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKST 458
+I L + +AE LKM+ L++++EELQ +L +L++E +
Sbjct: 1076 EQIADLQA-----QIAE----LKMQ----------LAKKEEELQAALARLDDEIAQKNNA 1116
Query: 459 ATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQL 518
+ L+ + DL+ +L+++ N++ +K L E+E L + ++ ++
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176
Query: 519 SKQQNEGDSIISKLKQDLNDEKKRVH--QLEDDKMDITKELDVQKEKLIQSEVALNDLHL 576
+K++ E ++ LK+ L DE+ R H Q+++ + + ++ E+L Q + A +L
Sbjct: 1177 AKREQE----VTVLKKAL-DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 577 TKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS---RIRNELMQSLNQ 633
KQ LE + +L +L ++ ++ + +L+ +++ + + S R R EL +++
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1291
Query: 634 DSNSNFKDT-LLKEREA-------EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685
N T +L E E +V +L L + ++L + + +V + +L
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
Query: 686 CEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEE 745
++ QL+E + L +T+ L K +++ + + L E +++K IE
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIEN 1410
Query: 746 LSNARNLNTSA----------LQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDV 795
L+ +A LQ E + L+ + ++ L+K + D E K++
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 796 LSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSL 855
S +E+ + +KE K + L+E L+ + R N++L+ +E+ L
Sbjct: 1471 SSKYADERDRAEAEAREKE---TKALSLARALEEALEAKEELERTNKMLKAEMED----L 1523
Query: 856 GSMKEE---NNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
S K++ N H E+ +R E Q + D + +L + L+ +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 913 KHHQKIIEDQNQSK-MQLLQSLQEQKKEMDEFRYQH-------EQMNATHTQLFLEKDEE 964
+ + ++QN+ K QL + L E + E+++ R Q +++ L L+ D
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 965 IKSLQKTIEQIK------TQLHEERQDIQTDNSDIF-----QETKVQSLNIENGSEKHDL 1013
IK ++ I+Q++ E +D + +IF E K +SL + + DL
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 1014 SKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD-EVGKLTQIIQQKDLEIQALH 1072
+ AE R +++ EL +L + + Q ++ + + +L + ++++ ++A+
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 1073 ARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAK-EA 1131
R+ TQ L +L +K + + R+N L+++ H+M V +K ++
Sbjct: 1764 DRVRKA--TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 1132 ALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSS 1191
+ L+ + +L + E REK +L QK + L +L
Sbjct: 1822 TIAALEAKIAQLEEQVEQEA---------------REKQAATKSLKQKDKKLKEILLQVE 1866
Query: 1192 TGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA 1251
+ Q E+ +LK+Q+++ EE Q++ + +Q E + E +
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1926
Query: 1252 QV 1253
+V
Sbjct: 1927 EV 1928
Score = 162 bits (409), Expect = 4e-39
Identities = 258/1201 (21%), Positives = 510/1201 (42%), Gaps = 186/1201 (15%)
Query: 76 TDLEEKHEASEIQI---KQQSTSYRNQLQQKEVEISHLKARQIALQDQL---LKLQSAAQ 129
T EE+ +A E ++ K++ N+L++ E + S L + LQ+QL +L + A+
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 130 SVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVG 189
+ A I H A +++ D G + Q E +++ ++ LE ++
Sbjct: 915 EMR-----VRLAAKKQELEEILHEMEARLEEEEDRGQQL--QAERKKMAQQMLDLEEQLE 967
Query: 190 HWRHIAQ-------TSKAQ------------GTDNSDQSEICKLQNIIKELKQNRSQEID 230
Q T++A+ +N E L+ I +L N ++E +
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-E 1026
Query: 231 DHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM 290
+ ++ L+N H+ ++E+ R ++E E+ +ELE L ++ +E D S +E
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKE----EKSRQELEKLKRK-----LEGDASDFHEQ 1077
Query: 291 QKTIQVLQIE-KVESTKKMEQLE-----------------DKIKDINKKLSSAENDRDIL 332
+Q E K++ KK E+L+ KI+++ +S + D D
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 333 RREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQ 392
R + + +KR + EE E LK E S Q + ++E +EV L++
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---------QEVTVLKK 1188
Query: 393 AL-SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNE 451
AL + + ++ + Q ++ A + +L ++E ++ K+ L + K+ L+ L E
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 452 YEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHM 511
V+ E+ + LEA+ QEL S+ E AE
Sbjct: 1247 LRVLGQA-------KQEVEHKKKKLEAQVQELQSKCSDGERARAE--------------- 1284
Query: 512 ILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVAL 571
+ D++ K QNE +S+ LN+ + + +L D ++ +L +E L +
Sbjct: 1285 --LNDKVHKLQNEVESVTGM----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 572 NDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSL 631
++ ++LE++ +L DQL++ E+ K+NLE HI +LS + +L
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEA-----KQNLE--RHISTLNIQLSDSKKKL---- 1387
Query: 632 NQDSNSNFK--DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDV 689
QD S + + K + E+ NL Q E + L+K ++ E + LV+ ++
Sbjct: 1388 -QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 690 RH---QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEEL 746
R LE+ +QL E+ I E+ EAE + + L A E+ +E
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506
Query: 747 SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL 806
N L+ E E L+ + EL+K+ ++T +E K L LE++ Q
Sbjct: 1507 EELERTN-KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQA 1564
Query: 807 TQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ 866
T+ +KL+ E++ + + L+ E+ + ++ + + +
Sbjct: 1565 TE---------------DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 867 EELERLREEQSRTAPV-----ADPKTLDSVTELASEVSQLNTIKE--HLEEEIKHHQKII 919
ELE R++++ A D K L+ + A + + IK+ L+ ++K Q+ +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQREL 1668
Query: 920 EDQNQSKMQLLQSLQEQKK-----EMDEFRYQHEQMNA--THTQLFLEKDEEIKSLQKTI 972
ED S+ ++ + +E +K E D + Q + A Q LEK+E + L ++
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 973 EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEI 1032
+ L +E++ ++ + + +E + + N+E S++ + + E+L +
Sbjct: 1729 SG-RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE---- 1783
Query: 1033 KLLNEKNISLTKQIDQLSKDEVGKLTQI---IQQK-DLEIQALHARISSTSHTQDVVYLQ 1088
+ +KN S +Q+++ +K+ KL ++ ++ K I AL A+I+ L+
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ---------LE 1834
Query: 1089 QQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFE 1148
+Q++ A E++ L +K + K+ +I L++++DE K E
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDK----------KLKEI-------LLQVEDERKMAEQYKE 1877
Query: 1149 SSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELL 1208
+ + R ++ L R + E + E ++ + L L ++ NEA G N + L
Sbjct: 1878 QAEKGNAR--VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Query: 1209 Q 1209
+
Sbjct: 1936 R 1936
Score = 151 bits (381), Expect = 7e-36
Identities = 218/1060 (20%), Positives = 434/1060 (40%), Gaps = 142/1060 (13%)
Query: 757 LQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL--------TQ 808
+Q + + L K +++ ELK+ +EQ + E K++L L+ + +L +
Sbjct: 861 MQAKEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 809 LINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
L KK+ E L E ++L+EE D+ Q + + + Q + + + L EE
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-----------EE 968
Query: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQ 928
E R++ A+ K + +L E+ ++ L +E +K++E++
Sbjct: 969 EEAARQKLQLEKVTAEAK----IKKLEDEILVMDDQNNKLSKE----RKLLEERISDLTT 1020
Query: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE----EIKSLQKTIEQIKTQLHEERQ 984
L +E+ K + + + +HE M + ++ L+K+E E++ L++ +E + HE+
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 985 DIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTK 1044
D+Q +++ + + ++ + D A+ +K I+E E I L E
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE------- 1132
Query: 1045 QIDQLSKDEVGKLTQIIQQKDL--EIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVF 1102
L + + Q++DL E++AL + T D QQ+L+A + V
Sbjct: 1133 ---DLDSERAARNKAEKQKRDLGEELEALKTELEDTL---DSTATQQELRAKREQEVTVL 1186
Query: 1103 A-VLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--I 1159
L+E+TR + + + +M A L + ++ K+ + + Q + +E +
Sbjct: 1187 KKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 1160 QNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVK 1219
R++ + E++ +K + + LQ+ + E N LQ ++++
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ--NEVESVTG 1301
Query: 1220 KMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNET 1279
+ E + + + +++ S+QLQ+ Q L+ + KL V T
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQD------TQELLQEETRQKLNVS------------T 1343
Query: 1280 KLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLS 1339
KL+ +E +Q + + K L + ++ QLS + A S E L
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA-----STVEALE 1398
Query: 1340 ESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK 1399
E + Q+E+E L + +EK A L++ +RL ++ D + L
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ--------------QELDDLVVDLD 1444
Query: 1400 EKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG 1459
++ ++ L K++ K DQLL+ +N ++K + +A KE
Sbjct: 1445 NQRQLVSNLEKKQ-----RKFDQLLAEEKNISSKYADERDRAEAEAREKET--------- 1490
Query: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQ 1519
K + R E +A +E M+ E E S + +L K K
Sbjct: 1491 -------KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 1520 GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
+T ++ ++ ++ ++++ Q D + Q + ++Q ++ +
Sbjct: 1544 LET-QMEEMKTQLEELEDE---LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 1580 ELER-LRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQA---S 1635
+L+R L + E ED + ALAA ++ KL + LE + S+ E A Q
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658
Query: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAEL 1695
Q++ Q +L RDE ++++ K L LQ E E+A A+L
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ---EDLAAAERARKQADL 1715
Query: 1696 EKQK---QLIAEWK-KNA-----ENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ 1746
EK++ +L + +NA LE ++ L+E L+E +++ S + + EQ
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 1747 IEE-------LKRQNELRQEMLDDVQKKLMSLANSSEGKV 1779
+ ++NE ++ L+ K+L S + EG V
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Score = 129 bits (324), Expect = 3e-29
Identities = 201/945 (21%), Positives = 392/945 (41%), Gaps = 160/945 (16%)
Query: 64 LRSENERLKKLCTDLEEKHEAS----EIQIKQQSTSYRN--QLQQK-EVEISHLKARQIA 116
L E E+ K L T L+ KHE+ E+++K++ S + +L++K E + S +
Sbjct: 1022 LAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 117 LQDQL--LKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEI 174
LQ Q+ LK+Q A + A + D + ++ ++I
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARL--------------------DDEIAQKNNALKKI 1120
Query: 175 NRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICK--LQNII------KELKQNRS 226
L +S L+ ++ R ++ Q D ++ E K L++ + +EL+ R
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 227 QEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSK 286
QE+ + + +H+ ++ E+ ++H + + + E++E+ + +T +
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKE 1239
Query: 287 IYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQI 346
++ ++VL K E K ++LE +++++ K S E R L + +L E +
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 347 MEECENLKLECSKLQPSAVKQSDTMTEKERILAQ--------SASVEEVFRLQQALSDAE 398
+ + KL S + + + +L + S + ++ + +L D
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 399 NEIMR--------LSSLNQDNSLAEDNLK-LKMRIEVLEKEKSLLSQEKEELQMSLLKLN 449
+E M +S+LN S ++ L+ +E LE+ K +E E L +
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 450 NEYEVIKSTATRDISLDSELHDLRL----------NLEAKEQELNQSISEKETLIAEI-E 498
Y+ ++ T R L EL DL + NLE K+++ +Q ++E++ + ++ +
Sbjct: 1420 AAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 499 ELDRQNQEA----TKHMILI---------KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQ 545
E DR EA TK + L K++L + + + L +D K VH+
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKS-QESNVSIQK 604
LE K + +++ K +L + E L K +LE ++ L Q + Q + ++
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 605 ENLELKEHIRQNEEELSRIRNE--LMQSLNQDSNSNFKD------TLLKEREAEVRNLKQ 656
+ +L+ + + E EL R + L + + + KD + +K RE ++ L++
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 657 NLSELEQLNENLKKVA------FDVKMENEKLVLACEDVRHQLEECLAG----NNQLSLE 706
++++ L+ F ENEK + E QL+E LA Q LE
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 707 KNTIVE----------TLKMEKGEIEAELCWAKKRLLEEANKYE----------KTIEEL 746
K + E L+ EK +EA + ++ L EE E + E+L
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Query: 747 SN--------ARNLNTSALQLEHEHLIKLNQKKDME-----------------IAELKKN 781
SN A+ ++ QLE ++ ++ +ME IA+L++
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 782 IEQ-----------MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
+EQ + K+ K++L +E+K Q + E ++K+ +L EE
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EE 1895
Query: 831 LDKYSQALRKNEI-LRQTIEEKDRSLGSMKEENNHLQEELERLRE 874
++ SQ + N L++ ++E S +M E N L+ +L R E
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKLRRGNE 1940
Score = 119 bits (297), Expect = 4e-26
Identities = 227/1059 (21%), Positives = 426/1059 (40%), Gaps = 174/1059 (16%)
Query: 741 KTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSL 800
K +E N + S + L L +++D++I ++ + M + K +
Sbjct: 759 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARK----AFA 814
Query: 801 EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKE 860
+ Q+QLT + + LK R+ + K L ++ RQ +E
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL---QVTRQ------------EE 859
Query: 861 ENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE 920
E ++EL++ +E Q K + + EL + SQL K L+E+++ ++
Sbjct: 860 EMQAKEDELQKTKERQQ--------KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 921 DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH 980
+ + +++L QE ++ + E + E+ QL E+ K + + + ++ QL
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLE 967
Query: 981 EERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL--EIKLLNEK 1038
EE E Q L +E + + + K E E LV + +L E KLL E+
Sbjct: 968 EE-------------EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHT-QDVVYLQQQLQAYAME 1097
LT + + +++ LT++ + + I L R+ + Q++ L+++L+ A +
Sbjct: 1015 ISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 1098 REKVFAVLNEKTRE--------NSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+ A L + E L+ ++ D +A K AL K+++ +S E
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
D R + R+ E++AL + + L ST + +EL
Sbjct: 1134 L--DSERAARNKAEKQKRDLGEELEALKTELEDTL-----DSTATQ---------QELRA 1177
Query: 1210 ERDKLKQQVKK-MEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYT 1268
+R++ +KK ++E + VQ M+ + AQ EEL + Q +K +D
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF-----KRAKANLD-- 1230
Query: 1269 GLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAE 1328
+N+ L+ +LA +GQ + KL+ +L S E
Sbjct: 1231 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC----SDGE 1279
Query: 1329 CLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1388
RA L++ LQ E+E + L E + L ++ LS + T EL ++E
Sbjct: 1280 RARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 1389 EQ---TDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVT 1445
Q ++++QL+E+++ LQ L E+ +A
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEE----------------------------MEAKQ 1367
Query: 1446 NLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKE 1505
NL+ I L + + K + + T +AL+E +F +E E +E
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTV-------EALEEGKKRFQ---KEIENLTQQYEE 1417
Query: 1506 KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565
KA A+++L K K N ++ + VV + Q++ L++KQ + L
Sbjct: 1418 KAAAYDKLEKTK------------NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465
Query: 1566 EVQRLRDK--EFRSNQELE-RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVS 1622
E + + K + R E E R + S EAL A++ + K + E LVS
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 1623 SSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEH 1682
S + + H+ +L+ Q+ + Q +E +L +++ + +++ L+ E
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 1683 ------FQQEEKAM--------YSAELE---KQKQLIAEWKKNAENLEGKVISLQECLDE 1725
Q EEK Y ELE KQ+ L A KK LEG + L+ +
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK---KLEGDLKDLEL---Q 1639
Query: 1726 ANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDV 1764
A++A+ +QL + Q+++ +R+ E + D++
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Score = 105 bits (262), Expect = 4e-22
Identities = 168/769 (21%), Positives = 319/769 (41%), Gaps = 102/769 (13%)
Query: 1055 GKLTQIIQQKDLEI----QALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110
G L + +++DL+I A A + QQQL A + + A L +
Sbjct: 780 GVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNW 839
Query: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKD 1170
+ L T+ ++ + +E K +DE +K R + ++ +E Q S++ EK+
Sbjct: 840 QWWRLFTKVKPLLQVTRQEEEMQAK-EDELQKTKER-QQKAENELKELEQKHSQLTEEKN 897
Query: 1171 I---------EIDA--------LSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDK 1213
+ E+ A L+ K Q L +L E ++ ++L ER K
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE---EEDRGQQLQAERKK 954
Query: 1214 LKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS 1273
+ QQ+ +EE ++ Q +Q E + ++ +L+ ++LV D N+KL + L
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL--- 1011
Query: 1274 YEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRAS 1333
E ++ + LA+ + L K+ S++ S
Sbjct: 1012 ----EERISDLTTNLAEEEEKAKNLTKLKN-------------KHESMI----------S 1044
Query: 1334 KSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDS 1393
+ EV + E +QELE+L++ L E DA+ + + +++D A +EL+
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKL-EGDAS-----DFHEQIADLQAQIAELKM-------- 1090
Query: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQL--LSSNENFTNKVNENELLRQAVTNLKERI 1451
QL +K++ LQ L D I K++ L + E + + E+ +A N E+
Sbjct: 1091 ---QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK- 1146
Query: 1452 LILEMDIGK----LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS----- 1502
+ D+G+ LK E E +++ + E +A +E + ++E H
Sbjct: 1147 --QKRDLGEELEALKTELEDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 1503 MKEK-ALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENT 1561
M++K A A E+L ++ EQ K + N N ++++++ E + A ++ + +
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 1562 ALQNEVQRLRDK---EFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEE 1618
L+ +VQ L+ K R+ EL + L +S T AE + KL K V L
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 1619 KLVSSSNAMENASHQ---ASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLAN 1675
+L + ++ + Q S ++ L+E+ N + Q DE + + + L++
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 1676 LQMVLEHFQ------QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAA 1729
+ L+ F +E K + E+E Q E + LE LQ+ LD+
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 1730 LDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGK 1778
LD+ +L L+ K+ + ++L + + D + + + A E K
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Score = 66.2 bits (160), Expect = 3e-10
Identities = 94/472 (19%), Positives = 196/472 (41%), Gaps = 72/472 (15%)
Query: 1367 QENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL---IKAKSDQL 1423
+E D + T E ++K ++E+K+L++K +L +EK+LL ++A+++
Sbjct: 858 EEEMQAKEDELQKTKERQQK----AENELKELEQKHS---QLTEEKNLLQEQLQAETELY 910
Query: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQ 1483
+ E + + L + + ++ R+ E +L+ E +K+ + E + + +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 1484 ETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQ 1543
K + E K K L E L+ + + K + +LL S + +
Sbjct: 971 AARQKLQL-----EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 1544 QERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALA-- 1601
+E+ + + LK K + ++ +E++ KE +S QELE+L+ LE + S E +A
Sbjct: 1026 EEKAKNLTKLKNK---HESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADL 1081
Query: 1602 ----------AEDREAKLRKKVTVLEEKLVSSSNAMEN--------------------AS 1631
+E +L+ + L++++ +NA++ A
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 1632 HQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMY 1691
++A Q L E+L + + ++T + QE + + L+ L+ + +A
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISL---QECLDEANAALDSASRLTEQLDVK----- 1743
+K Q + E + E + +L ++ L++ NA L R+ Q +
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 1744 ---EEQIEELKRQ----NELRQEMLDDVQK------KLMSLANSSEGKVDKV 1782
E Q++EL+ + R E+ D V K + + N +EGK K+
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Score = 47.8 bits (112), Expect = 1e-04
Identities = 65/349 (18%), Positives = 128/349 (36%), Gaps = 23/349 (6%)
Query: 38 LMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYR 97
L E E EL D R + A A + E + LK L + + E IKQ +
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR---K 1656
Query: 98 NQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAF 157
Q Q K+ + AR A +D++ + A A
Sbjct: 1657 LQAQMKDFQRELEDAR--ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 158 HDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNI 217
+ + ++ SS N L +E RLE+ + + + QG + + K
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRKATQQ 1772
Query: 218 IKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGS 277
++L + E Q S Q +Q + ++ E+E ++
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQN------------KELRSKLHEMEGAVKSKFK 1820
Query: 278 GVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQE 337
I +KI ++++ ++ EK +TK ++Q + K+K+I ++ + + + E
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 338 QLNVEKRQIMEECENLKLECSKLQPSAVK---QSDTMTEKERILAQSAS 383
+ N +Q+ + E + E ++ + K + D TE + + +
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 38.1 bits (87), Expect = 0.086
Identities = 35/148 (23%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ-QEEKAMYSAE 1694
+QV +E++ Q E LQ + ++Q + L ++ +H Q EEK + +
Sbjct: 852 LQVTRQEEEM-----QAKEDELQKTKERQQKAENELK----ELEQKHSQLTEEKNLLQEQ 902
Query: 1695 LEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQN 1754
L+ + +L AE ++ L K L+E L E A L+ +QL + +++ +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 1755 ELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
E + E + ++KL ++E K+ K+
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKL 990
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 178 bits (452), Expect = 4e-44
Identities = 346/1697 (20%), Positives = 687/1697 (40%), Gaps = 229/1697 (13%)
Query: 170 SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS-------EICKLQNIIKELK 222
+Q E+ L V+RL +E + + S A T S+ ++ L I E
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET 282
+ S I Q VL+ AH+++L E ++ L + E L+ L Q +
Sbjct: 1089 KTISLVIRGTQGAEEVLR-AHEEQLKE-AQAVPATLPELEATKASLKKLRAQAEAQQPTF 1146
Query: 283 DL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
D ++ Q+ + LQ E ++E+ +++ + ++ + D+ +RE EQL
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1206
Query: 341 VEKRQIMEECENL-----KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395
+ R E + L + Q A+ +D+ +E++ + A +EE+ R + +
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1266
Query: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455
+ + + + +D L K ++ +K + E + + L Y +
Sbjct: 1267 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILI 514
+ ++ I SE LR +E +E+ Q +E+ +AE+E L++Q Q A H
Sbjct: 1327 TTLTSQYIKFISET--LR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA--- 1380
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+K Q E ++ +L+Q + +E R + D Q+++ IQ E L
Sbjct: 1381 ---QAKAQAEREA--KELQQRMQEEVVRREEAAVDAQ--------QQKRSIQEE-----L 1422
Query: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD 634
+Q E +++ Q ++ S + I++E ++ + E + EL +
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482
Query: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDVR 690
+ + +E +R Q+ S+ ++ E + K + E ++ + A E++R
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542
Query: 691 HQLEECLAGNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
Q EE Q +E+ V+ L+ + EAEL + E+ + E++++E
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE--- 1599
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIA--ELKKNIE--QMDTDHKETKDVLSSSLEEQKQ 805
+ + QL E + Q+ + E A E ++ +E Q+ + + + + +QK
Sbjct: 1600 ---HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 806 LTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
L Q K++ E+ R K +E QA+R+ E+ Q +E++ + ++
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
++EL RLR E TE + QL LEEE+ Q+ Q
Sbjct: 1711 AEQELIRLRAE----------------TEQGEQQRQL------LEEELARLQREAAAATQ 1748
Query: 925 SKMQLLQSLQEQKKEMD-----EFRYQHEQMNATHTQL---------FLEKDEEIKSLQK 970
+ +L L + + EM+ + R + E + + F E EE L+
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1808
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
E+ K Q +D Q + + + E + + ++ +TE + +KE+E
Sbjct: 1809 LAEEAKRQRQLAEEDAAR------QRAEAERVLAEKLAAIGEATRLKTEAEI-ALKEKEA 1861
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
E +++ +L++DE Q++ LE QA H D+ Q
Sbjct: 1862 E-----------NERLRRLAEDEA------FQRRRLEEQA-------AQHKADIEERLAQ 1897
Query: 1091 LQ-AYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
L+ A E E+ ++ + R+ ++ E ++ + A+ E A + +L R S
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEE---ILALKASFEKAAAGKAELELELG-RIRS 1953
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+ +D R Q R++ + + ++ + V ++ + EA + Q + L+
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA----ARQRKAALE 2009
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTG 1269
E ++LK +V++ +++ QE QLQ L +LQ +
Sbjct: 2010 EVERLKAKVEEARRLRERAE-------------QESARQLQ---LAQEAAQKRLQAEEKA 2053
Query: 1270 LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD------IISPQLSSASLLT 1323
+ +Q E +L+ Q L Q Q + QL + + + + + ++ S
Sbjct: 2054 HAFAVQQKEQELQ---QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
+ AE L+ S E ++ Q E+LRK +++ A R Q L AA +E+
Sbjct: 2111 VEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEM 2167
Query: 1384 ER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
E+ K EQT + Q++++ L+ L+E D ++L T + +
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE------ 1495
+ + +++ ++ L +++ EN ++ R K+ + LQE K + E
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 1496 --------KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER- 1546
++ + ++ E++LKEK Q A Q+K + +Q R
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 1547 ---DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
D+ +A +Q E Q ++ R ++ + E ERL+ + E + R AE
Sbjct: 2346 LQEDKEQMA-QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR----AE 2400
Query: 1604 DREAKLRKKVTVLEEKL----------VSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
+ + RK+ + EKL V+ +E Q+ E L+E + + ++++
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 1654 ETA-----LQL------SVSQEQV-------KQYALSLANLQMVLEHFQQEEKA----MY 1691
+ LQL +V QEQ+ +Q LS + + E F ++EKA ++
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
E+ K +QL E ++ + +E + L ++EA A + + +Q+E+ +
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 1752 RQNELRQEMLDDVQKKL 1768
RQ E E+L + ++L
Sbjct: 2581 RQQE---ELLAEENQRL 2594
Score = 159 bits (402), Expect = 3e-38
Identities = 292/1451 (20%), Positives = 593/1451 (40%), Gaps = 171/1451 (11%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHE 83
A L S K + G+E V E D RT E L + + K ++ + E
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTTLTSQYIKFISETLRRME 1345
Query: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
E +QQ R +L EVE + K RQ+A K Q+ ++ +
Sbjct: 1346 EEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 144 SSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL----ESEVGHWRHIAQTSK 199
A + +QQ+ + E+ +L E+E+ A+ ++
Sbjct: 1404 REEA-------------------AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444
Query: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
++ + +LQ E ++ ++ + A +++ E + R R ++
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ---IEKVESTKKMEQLE-DKI 315
D +R + E L + ++ + E Q+ +Q L+ ++ E+ +++ Q E ++
Sbjct: 1505 DESQRKRQAEVEL----ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 316 KDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+ + L +A+ R + +L ++ E+ L+ LQ V + E E
Sbjct: 1561 RQVQVALETAQ------RSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAE 1611
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R Q A E +A +AE E+ R A + L+L+++ E + ++KSL
Sbjct: 1612 RRAQQQAEAE------RAREEAERELERWQLK------ANEALRLRLQAEEVAQQKSLAQ 1659
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISL-DSELHDLRLNLEAKEQELNQSISEKETLI 494
E E+ + + + A R L + EL R E Q+ + E L
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
AE E+ ++Q Q L++++L++ Q E + K +Q+L E +V
Sbjct: 1720 AETEQGEQQRQ-------LLEEELARLQREAAAATQK-RQELEAELAKVR---------- 1761
Query: 555 KELDVQKEKLIQSEV-ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
+ E L+ S+ A + T +K + ++E + + E ++ E K
Sbjct: 1762 ----AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
+ EE+ +R R E + L + + + T LK EAE+ LK+ +E NE L+++A
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIA-LKEKEAE----NERLRRLAE 1871
Query: 674 DVKMENEKLVLACEDVRHQLEECL-----AGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
D + +L + +EE L A +++L +K + +TL+ ++ ++E E+ A
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEEEIL-A 1929
Query: 729 KKRLLEEANKYEKTIE-ELSNARNLNTSAL------QLEHEHLIKLNQKKDMEIAELKKN 781
K E+A + +E EL R+ L +LE +L +++ E ++
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSK----LQEELDKYSQA 837
+++ +E ++LEE ++L + + E+ ++ S++ QE K QA
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASE 897
K +++K++ L ++ + ++L E R A A+ + + E A
Sbjct: 2050 EEKAHAF--AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Q+ EE + ++ E+Q Q++ Q + ++ +KE ++ + Q +
Sbjct: 2108 RRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDI--------QTDNSDIFQETKVQSLNIENGSE 1009
D E++ +K EQ Q + Q++ +TD+ + ++Q L E
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 1010 KHDLSKAETERLVKGIKERE---LEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQQ 1063
S+ E E ++ E L+ ++ E + + D + +E K+ Q+ ++
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 1064 -KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
L + A A +D+ QQ+ A M +EK+ AV +E + LK E +
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLA--QQRALAEKMLKEKMQAV-----QEATRLKAEAELL 2332
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKC 1180
KE A Q++ ++L E Q + ET Q R++ +E+ A +++
Sbjct: 2333 QQ---QKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+ +A + + E + ++ +++ +++ + E Q+ +T VQ ++ +
Sbjct: 2386 KLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Q + +L+ + KLQ + L ++S E + + QE +Q S
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS---FL 2496
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK----S 1355
+ KD LL + I + + L +K++ L E + QQ++E+ R+ S
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQD-----EVAKAQQLREEQQRQQQQMEQERQRLVAS 2551
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++E +E R + + + R++ E E ++L+E+ +LL+E+
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ----LQLLEEQHRA 2607
Query: 1416 IKAKSDQLLSS 1426
A S+++ +S
Sbjct: 2608 ALAHSEEVTAS 2618
Score = 128 bits (322), Expect = 5e-29
Identities = 319/1545 (20%), Positives = 631/1545 (40%), Gaps = 244/1545 (15%)
Query: 467 SELHDLRLNLEAKE----------------QELNQSISEKETLIAEIEELD----RQNQE 506
SEL D+RL LEA E +E Q I+E++ AE+E L R + E
Sbjct: 987 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046
Query: 507 ATKHMILIKDQLSKQ--QNEGDSIISKLKQDLN------DEKKRVHQLEDDKMDITKELD 558
A K + L + + ++E + + KL+Q + ++ K + + + L
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1106
Query: 559 VQKEKLIQSE---VALNDLHLTKQKL----------EDKVENLVDQLNKSQESNVSIQKE 605
+E+L +++ L +L TK L + + L D+L +QE +Q+
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166
Query: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQN-------L 658
+ E + + E ++++ L Q ++ + L++ ++R +++ L
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQ---TDVRQRELEQLGRQLRYYRESADPLGAWL 1223
Query: 659 SELEQLNENLKKVAF-DVKMENEKL----VLACEDVRH--QLEECLAGNNQLSLEKNTIV 711
+ + E ++ + D + E+L L E RH ++EEC Q
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
L K ++E AKK ++ + E I+E + R + L ++ IK +
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQY-IKFISET 1340
Query: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK-LKERSSKLQEE 830
+ E ++ EQ + +E + ++LE+Q+QL + + + E+ KE ++QEE
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ----EELERLR---EEQSRTAPVA 883
+ + +A + +++I+E+ + L E + E ER R EE+ R +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 884 DPKT-------LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL--- 933
T + L + + K +EE + ++ ++D++Q K Q L
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 934 -----------QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK-SLQKTIEQIKTQLHE 981
Q + ++E R Q E+ Q +E+ +++ +L+ + +L
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 982 ERQDIQTDNSDI---FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELE------- 1031
+R + + QE V + +E+ +AE ER + ERELE
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER-AREEAERELERWQLKAN 1639
Query: 1032 --IKL-LNEKNISLTKQIDQL----SKDEV-------GKL-TQIIQQKDLEIQALHARIS 1076
++L L + ++ K + Q K+E GK Q ++Q++L Q L +
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 1077 STSHT--------QDVVYL-------QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 1121
T Q+++ L +QQ Q E ++ T++ L+ E K
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 1122 ----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI-------IREKD 1170
M ++A+K A + + ++K R E+ FRE + +R+ R++
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAEEAARLRALAEEAKRQRQ 1818
Query: 1171 I-EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM--EEWKQQ 1227
+ E DA Q+ + + + + EA + + + E L+E++ ++++++ +E Q+
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDEAFQR 1877
Query: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Q QH+ A ++E L QL+ + + L D + E+ LK ++
Sbjct: 1878 RRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 1288 L----AQVQHSIGQL-CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
A+++ +G++ N +D L K +L +A + E R ++E + S
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSK---EQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS---------------ELERKE 1387
++E RK+ E+ ++ E RL + S + E K
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 1388 H----EQTDSEIKQ-LKEKQDVLQKLLKEKDLLIKAKSD------QLLSSNENFTNKVNE 1436
H +Q + E++Q L+++Q VL +L E + +A + Q +V E
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
E L+Q+ + + KL+ E E+ E R + E AL++ + M + K
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 1497 EFECHSMKEKALAFEQL--LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV--MLA 1552
+F ++++KA ++L L+ + + + N L ++ ++ + ++R QV L
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231
Query: 1553 LKQKQMENTA-------LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED- 1604
+ QME + +N LRDK+ + + L+ + + + R ++AA++
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 1605 ------REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
E L ++ + E+ L A++ A+ + + E LQ+Q + +Q A +
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQEQ----ARR 2345
Query: 1659 LSVSQEQV-KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW-------KKNAE 1710
L +EQ+ +Q A Q LE +Q + M SAE E+ K +AE +++A+
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ-----------IEELKRQNE---- 1755
+ + E L A L + L+++ +Q I EL+R+ E
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 1756 ------LRQEMLDDVQKKLM-----SLANSSEGKVDKVLMRNLFI 1789
L+ E + VQ++ + +L S + D +L R FI
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Score = 119 bits (298), Expect = 3e-26
Identities = 237/1253 (18%), Positives = 497/1253 (39%), Gaps = 200/1253 (15%)
Query: 586 ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
+ L+ L + + Q+ ELK+ Q E +R + L L+++ + +
Sbjct: 966 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025
Query: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL------ACEDVRHQLEECLAG 699
+++A+ +E+E L + + +++ E EK++ A +R +LE L
Sbjct: 1026 QQKAQ--------AEVEGLGKGVARLS----AEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 700 NNQLSLEKNTIVETLKMEKGEIEA-----ELCWAKKRLLEEANKYEKTIEELSNARNLNT 754
Q+ +E LK I E+ A + L+EA T+ EL +
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK---- 1129
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ +L+ E +D L + E ++L Q +++
Sbjct: 1130 ------------------ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE--RL 872
+ +E+ +ER ++L L+++ L + ++ ++ +E+ R L +E + L L+ R
Sbjct: 1172 VEVERWRERVAQL---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
R+EQ + P+AD + + QL + LEE +H +K+ E Q +K Q + +
Sbjct: 1229 RQEQIQAMPLADSQAVRE---------QLRQEQALLEEIERHGEKVEECQRFAK-QYINA 1278
Query: 933 LQEQKKEMDEFRYQHE-----------------------QMNATHTQLFLEKDEEIKSLQ 969
+++ + ++ ++ Q E + +++L + IK +
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
+T+ +++ + Q + + + E + +E H +KA+ ER K +++R
Sbjct: 1339 ETLRRMEEEERLAEQQ-RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
E +++ + ++ Q + S E +L Q+ Q + EIQA + + ++ + +++
Sbjct: 1398 QE-EVVRREEAAVDAQQQKRSIQE--ELQQLRQSSEAEIQAKARQAEAAERSR--LRIEE 1452
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+++ ++ E R+ + E + EA + Q+E ++L + +
Sbjct: 1453 EIRVVRLQLEAT-------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Query: 1150 SGQDMFRETIQNLSRI------IREKDIEIDALSQ------------------KCQTLLA 1185
Q + ++ SR+ REK + AL + + + +
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 1186 VLQTSSTGNEAG--------GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
L+T+ EA + Q E LQE Q+++ E + Q + +
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
E A+ + E QL+A + +LQ + +S Q E + ++ + + +
Sbjct: 1626 E-AERELERWQLKANEAL----RLRLQAEEVAQQKSLAQAEAE-----KQKEEAEREARR 1675
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
++ + + ++ +L L +A+ A+ +QEL LR +
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA------------EQELIRLRAETE 1723
Query: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL---QKLLKEKDL 1414
+ + + L+E RL AA ++ + ++ ++E+ +++ + +VL + +E+
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQ----KRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 1415 LIKAKSDQLLSSNEN-FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIV---- 1469
KS Q L + F E LR K + + E D + + E E+++
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 1470 ----ETYRGKETEYQALQET---NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
E R K AL+E N + + ++ F+ ++E+A + ++E+
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
+ L K + E T+ +++ ++ +LALK + A + E++ L RSN E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE-LELGRIRSNAEDT 1958
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
E E + R+ A E+R + EE++ S A E A+ Q +E ++
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
+ +K + L+ QE +Q L A+ QK+L
Sbjct: 2013 R---LKAKVEEARRLRERAEQESARQLQL---------------------AQEAAQKRLQ 2048
Query: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNE 1755
AE K +A ++ K LQ+ L + + LD E E+ EE + Q E
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Score = 92.8 bits (229), Expect = 3e-18
Identities = 131/757 (17%), Positives = 311/757 (41%), Gaps = 65/757 (8%)
Query: 41 GTEEVEAELPDSRTKEIEAIHAILRSENE--RLKKLCTDLEEKHEASEIQIKQQSTSYRN 98
G E+E EL R+ + + + ++E E R ++L + E + +E ++++ +
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+Q++ + ++ + +++ + A Q + A H A
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 159 DDDMDFGDIISSQQEI-NRLSNEVS---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+ + + +Q + ++L E R E R A+ AQ +++E
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE---- 2115
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
LKQ+ ++ + + ++ E +RR + E + ++ + + +
Sbjct: 2116 -----RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEME 2168
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
E L + ++++ + L+++ E+ + L+++++ + + + A R +
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228
Query: 335 EQEQLNVEKRQIME-----ECENLKLECSK-------LQPSAVKQSDTMTEKERILAQSA 382
E + V+ ++ + E EN L LQ A K E R+ S
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL---SV 2285
Query: 383 SVEEVFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL------- 433
+ +E RL+Q + A+ + L + ++ +LK E+L+++K L
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 434 LSQEKEELQMSLLKLNNEYE-VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
L ++KE++ L + ++ +++ R + + +E RL L E Q+ +E++
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE--RLKLRVAEMSRAQARAEEDA 2403
Query: 493 L-----IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---DLNDEKKRVH 544
EI E + + AT+ + + L Q+ + D +L++ +L EK+++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 545 QLEDDKMDITKE--LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSI 602
Q E + + E VQ+E+L+Q AL L+++ + E ++Q E
Sbjct: 2464 Q-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 603 QKENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+ + L+E ++ ++++ + R L+ S+ + ++ EAE +++ EL
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR--------RQHEAE-EGVRRKQEEL 2573
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
+QL + ++ + EN++L + + Q LA + +++ + +TL + +
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+ A+ + + + + + L A L+ LQ
Sbjct: 2634 DGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2670
Score = 83.2 bits (204), Expect = 2e-15
Identities = 194/1114 (17%), Positives = 417/1114 (37%), Gaps = 196/1114 (17%)
Query: 734 EEANKYEKTIEELSNARNLNTSALQLEHEHLIKL----------------NQKKDMEIAE 777
+E ++ ++ I EL + R L A + H ++L QK E+
Sbjct: 977 QEESRCQRCISELKDIR-LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1035
Query: 778 LKKNIEQMDTDHKET---------KDVLSSSLE-EQKQLTQLINKKEIFIEKLKERSSKL 827
L K + ++ + ++ L S LE +L Q+ + I++EKLK S +
Sbjct: 1036 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1095
Query: 828 ------QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
+E L + + L++ + + T+ E + + S+K +LR + P
Sbjct: 1096 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-----------KLRAQAEAQQP 1144
Query: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
D L E+ + E L++ +E + QLL+ Q + D
Sbjct: 1145 TFDA--------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1196
Query: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE-ERQDIQTDNSDIFQETKVQ 1000
+ + EQ+ + + E + + + + + + Q+ D Q + QE +
Sbjct: 1197 VRQRELEQLGR-QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
IE EK + + ++ + IK+ EL++ + L K +V ++
Sbjct: 1256 E-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1311
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
+ Q+ ++++ ++ +++ + +Q + ++ + L+ E E+ + ++
Sbjct: 1312 VIQEYVDLRTHYSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1370
Query: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
K + A A + + E K+L R + ++R ++ +DA
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEE--------------VVRREEAAVDA----- 1411
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+QQ + ++E QQ+ Q A
Sbjct: 1412 ----------------------------------QQQKRSIQEELQQLR------QSSEA 1431
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
++Q + Q +A S+L+++ + + T+ + G E
Sbjct: 1432 EIQAKARQAEAA------ERSRLRIEEEIRVVRLQLEATERQRGGAE------------- 1472
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
G+L + + A Q+ E + +V ES Q E+E + E +
Sbjct: 1473 ------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
A +E L + E E +E+++ ++ Q L+ + + +++K
Sbjct: 1527 AA----REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582
Query: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
+ E + AV L+E + + ++ E R +E +
Sbjct: 1583 ASFAEKTAQLERSLQEEHV---AVAQLRE----------EAERRAQQQAEAERAREEAER 1629
Query: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
L+ +K + LR + ++K+LA + K+KE+ + + ++++++ +
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689
Query: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Q+ Q LA Q + A + E+ RLR + + Q+ + L L + REA
Sbjct: 1690 AEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ----REAA 1744
Query: 1601 AA----EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
AA ++ EA+L K +E L S + A E + + + L+ + + +E A
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK--QKQLIAEWKKNAENLEG 1714
++++E +Q L+ +E+ A AE E+ ++L A + E
Sbjct: 1805 RLRALAEEAKRQRQLA------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 1715 KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
++ L E A + RL E + ++EE Q++ D++++L L +
Sbjct: 1853 EI-----ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA------DIEERLAQLRKA 1901
Query: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGS 1808
S+ ++++ + L + E+L L S
Sbjct: 1902 SDSELER--QKGLVEDTLRQRRQVEEEILALKAS 1933
Score = 70.1 bits (170), Expect = 2e-11
Identities = 268/1447 (18%), Positives = 557/1447 (38%), Gaps = 159/1447 (10%)
Query: 474 LNLEAKEQELNQSISEKET-LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
L++E + +L+ +I E+E L +E E L+ + TK + + +Q N+ D+++
Sbjct: 364 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTK-LQMEAGLCEEQLNQADALLQSD 422
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ L K + ++ ++LD + + +I+ + ND+ K + E + ++
Sbjct: 423 VRLLAAGK-----VPQRAGEVERDLD-KADSMIR--LLFNDVQTLKDGRHPQGEQMYRRV 474
Query: 593 NKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLK---- 645
+ E V+I+ E NL LK + +++++ + +Q + DS + LL
Sbjct: 475 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEE 534
Query: 646 --------EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
E ++ +++ L L++++++ ++ R +CL
Sbjct: 535 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL 594
Query: 698 AGNNQLSLEKNTIVETLKMEKGEIEAE---LCWAKKRLLEEANKYEKTIEELSNARNLNT 754
+L L+ ++ + K +E+ + A K L+ K E+ + + RN N
Sbjct: 595 G---RLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNM 651
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQM-DTDHKETKDVLSSSLEEQKQLTQLINKK 813
+A + + L++ + K+ +I EL+ +++ DH V S Q Q + ++
Sbjct: 652 TAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLC 711
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
LKE ++ Q D ++E LQ+ E LR
Sbjct: 712 CCIEAHLKENAAYFQFFSD-------------------------VREAEGQLQKLQEALR 746
Query: 874 EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE-------DQNQSK 926
+ S + D + + E QLN K HL K + +++ + +
Sbjct: 747 RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 806
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQM------------------NATHTQLFL------EKD 962
+ LL ++ E+ + Q+ A + FL E
Sbjct: 807 LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 866
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
E + L+ + + T H+ D+++ + VQ + + + L K E +R
Sbjct: 867 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTL-KPEEQRQA 925
Query: 1023 KGIKERELEIKLLNEKNISLTKQIDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHT 1081
E + L + ++ D+L ++ E G + QQ +Q+L S
Sbjct: 926 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRC 982
Query: 1082 QDVV--YLQQQLQAYAMEREKVFAVL----NEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Q + +LQ A E V + E RE + E K V + +
Sbjct: 983 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1042
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS----QKCQTLLAVLQTSS 1191
L E +K+ E S T+++ + K ++ +LS +K +T+ V++ +
Sbjct: 1043 LSAEAEKVLALPEPSPA---APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1099
Query: 1192 TGNEAGGVNSNQFEE------LLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
E + Q +E L E + K +KK+ + T ++ E QE
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1159
Query: 1246 LHQLQ-------AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
+LQ +V + ++L + ++ + + +L+ G++L + S L
Sbjct: 1160 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1219
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSA-ECLRASKSEVLSESSELLQQELEELRKSLQ 1357
L Q+ + L Q+ E LR + + L E E +++EE ++ +
Sbjct: 1220 ----GAWLQDARRRQEQIQAMPLADSQAVREQLR--QEQALLEEIERHGEKVEECQRFAK 1273
Query: 1358 EKDATIR--TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+ I+ LQ ++ A+ + K ++S I++ + + +L
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
IK S+ L E E L Q +ER+ +E + K + E +
Sbjct: 1334 IKFISETLRRMEE-------EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 1476 ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
E E + LQ+ + ++R +E + ++K + ++ L++ Q E+ ++
Sbjct: 1387 EREAKELQQRMQE--EVVRREEAAVDAQQQKR-SIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 1536 QEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRNHL 1588
+ + ++E V L L+ + + + E+Q LR + + ++ +E ERLR +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
+D R+ A + ++++ + EK + A+E QA + E Q V
Sbjct: 1504 ---QDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQAE-EAERRLRQAEVE 1558
Query: 1649 SKQRDETALQLS--VSQEQVKQYALSLANLQMVLEHFQQEEK---AMYSAELEKQKQLIA 1703
++ + AL+ + ++ +++ S A LE QEE A E E++ Q A
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
E ++ E E ++ Q +EA A + +Q + + + E+ K + E
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 1764 VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHD 1823
+++ + +E +++K R L G E++RL + E+ QL +
Sbjct: 1679 AEEQAVRQRELAEQELEK--QRQLAEGTAQQRLAAEQELIRLRAET--EQGEQQRQLLEE 1734
Query: 1824 DQGGVTR 1830
+ + R
Sbjct: 1735 ELARLQR 1741
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 178 bits (452), Expect = 4e-44
Identities = 346/1697 (20%), Positives = 687/1697 (40%), Gaps = 229/1697 (13%)
Query: 170 SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS-------EICKLQNIIKELK 222
+Q E+ L V+RL +E + + S A T S+ ++ L I E
Sbjct: 1033 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1092
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET 282
+ S I Q VL+ AH+++L E ++ L + E L+ L Q +
Sbjct: 1093 KTISLVIRGTQGAEEVLR-AHEEQLKE-AQAVPATLPELEATKASLKKLRAQAEAQQPTF 1150
Query: 283 DL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
D ++ Q+ + LQ E ++E+ +++ + ++ + D+ +RE EQL
Sbjct: 1151 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1210
Query: 341 VEKRQIMEECENL-----KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395
+ R E + L + Q A+ +D+ +E++ + A +EE+ R + +
Sbjct: 1211 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1270
Query: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455
+ + + + +D L K ++ +K + E + + L Y +
Sbjct: 1271 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1330
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILI 514
+ ++ I SE LR +E +E+ Q +E+ +AE+E L++Q Q A H
Sbjct: 1331 TTLTSQYIKFISET--LR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA--- 1384
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+K Q E ++ +L+Q + +E R + D Q+++ IQ E L
Sbjct: 1385 ---QAKAQAEREA--KELQQRMQEEVVRREEAAVDAQ--------QQKRSIQEE-----L 1426
Query: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD 634
+Q E +++ Q ++ S + I++E ++ + E + EL +
Sbjct: 1427 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1486
Query: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDVR 690
+ + +E +R Q+ S+ ++ E + K + E ++ + A E++R
Sbjct: 1487 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1546
Query: 691 HQLEECLAGNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
Q EE Q +E+ V+ L+ + EAEL + E+ + E++++E
Sbjct: 1547 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE--- 1603
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIA--ELKKNIE--QMDTDHKETKDVLSSSLEEQKQ 805
+ + QL E + Q+ + E A E ++ +E Q+ + + + + +QK
Sbjct: 1604 ---HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1660
Query: 806 LTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
L Q K++ E+ R K +E QA+R+ E+ Q +E++ + ++
Sbjct: 1661 LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLA 1714
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
++EL RLR E TE + QL LEEE+ Q+ Q
Sbjct: 1715 AEQELIRLRAE----------------TEQGEQQRQL------LEEELARLQREAAAATQ 1752
Query: 925 SKMQLLQSLQEQKKEMD-----EFRYQHEQMNATHTQL---------FLEKDEEIKSLQK 970
+ +L L + + EM+ + R + E + + F E EE L+
Sbjct: 1753 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1812
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
E+ K Q +D Q + + + E + + ++ +TE + +KE+E
Sbjct: 1813 LAEEAKRQRQLAEEDAAR------QRAEAERVLAEKLAAIGEATRLKTEAEI-ALKEKEA 1865
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
E +++ +L++DE Q++ LE QA H D+ Q
Sbjct: 1866 E-----------NERLRRLAEDEA------FQRRRLEEQA-------AQHKADIEERLAQ 1901
Query: 1091 LQ-AYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
L+ A E E+ ++ + R+ ++ E ++ + A+ E A + +L R S
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEE---ILALKASFEKAAAGKAELELELG-RIRS 1957
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+ +D R Q R++ + + ++ + V ++ + EA + Q + L+
Sbjct: 1958 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA----ARQRKAALE 2013
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTG 1269
E ++LK +V++ +++ QE QLQ L +LQ +
Sbjct: 2014 EVERLKAKVEEARRLRERAE-------------QESARQLQ---LAQEAAQKRLQAEEKA 2057
Query: 1270 LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD------IISPQLSSASLLT 1323
+ +Q E +L+ Q L Q Q + QL + + + + + ++ S
Sbjct: 2058 HAFAVQQKEQELQ---QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2114
Query: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
+ AE L+ S E ++ Q E+LRK +++ A R Q L AA +E+
Sbjct: 2115 VEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEM 2171
Query: 1384 ER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
E+ K EQT + Q++++ L+ L+E D ++L T + +
Sbjct: 2172 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2231
Query: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE------ 1495
+ + +++ ++ L +++ EN ++ R K+ + LQE K + E
Sbjct: 2232 EELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2289
Query: 1496 --------KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER- 1546
++ + ++ E++LKEK Q A Q+K + +Q R
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 1547 ---DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
D+ +A +Q E Q ++ R ++ + E ERL+ + E + R AE
Sbjct: 2350 LQEDKEQMA-QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR----AE 2404
Query: 1604 DREAKLRKKVTVLEEKL----------VSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
+ + RK+ + EKL V+ +E Q+ E L+E + + ++++
Sbjct: 2405 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2464
Query: 1654 ETA-----LQL------SVSQEQV-------KQYALSLANLQMVLEHFQQEEKA----MY 1691
+ LQL +V QEQ+ +Q LS + + E F ++EKA ++
Sbjct: 2465 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2524
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
E+ K +QL E ++ + +E + L ++EA A + + +Q+E+ +
Sbjct: 2525 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2584
Query: 1752 RQNELRQEMLDDVQKKL 1768
RQ E E+L + ++L
Sbjct: 2585 RQQE---ELLAEENQRL 2598
Score = 159 bits (402), Expect = 3e-38
Identities = 292/1451 (20%), Positives = 593/1451 (40%), Gaps = 171/1451 (11%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHE 83
A L S K + G+E V E D RT E L + + K ++ + E
Sbjct: 1295 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTTLTSQYIKFISETLRRME 1349
Query: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
E +QQ R +L EVE + K RQ+A K Q+ ++ +
Sbjct: 1350 EEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1407
Query: 144 SSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL----ESEVGHWRHIAQTSK 199
A + +QQ+ + E+ +L E+E+ A+ ++
Sbjct: 1408 REEA-------------------AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1448
Query: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
++ + +LQ E ++ ++ + A +++ E + R R ++
Sbjct: 1449 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1508
Query: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ---IEKVESTKKMEQLE-DKI 315
D +R + E L + ++ + E Q+ +Q L+ ++ E+ +++ Q E ++
Sbjct: 1509 DESQRKRQAEVEL----ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1564
Query: 316 KDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+ + L +A+ R + +L ++ E+ L+ LQ V + E E
Sbjct: 1565 RQVQVALETAQ------RSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAE 1615
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R Q A E +A +AE E+ R A + L+L+++ E + ++KSL
Sbjct: 1616 RRAQQQAEAE------RAREEAERELERWQLK------ANEALRLRLQAEEVAQQKSLAQ 1663
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISL-DSELHDLRLNLEAKEQELNQSISEKETLI 494
E E+ + + + A R L + EL R E Q+ + E L
Sbjct: 1664 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1723
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
AE E+ ++Q Q L++++L++ Q E + K +Q+L E +V
Sbjct: 1724 AETEQGEQQRQ-------LLEEELARLQREAAAATQK-RQELEAELAKVR---------- 1765
Query: 555 KELDVQKEKLIQSEV-ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
+ E L+ S+ A + T +K + ++E + + E ++ E K
Sbjct: 1766 ----AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1821
Query: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
+ EE+ +R R E + L + + + T LK EAE+ LK+ +E NE L+++A
Sbjct: 1822 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIA-LKEKEAE----NERLRRLAE 1875
Query: 674 DVKMENEKLVLACEDVRHQLEECL-----AGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
D + +L + +EE L A +++L +K + +TL+ ++ ++E E+ A
Sbjct: 1876 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEEEIL-A 1933
Query: 729 KKRLLEEANKYEKTIE-ELSNARNLNTSAL------QLEHEHLIKLNQKKDMEIAELKKN 781
K E+A + +E EL R+ L +LE +L +++ E ++
Sbjct: 1934 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1993
Query: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSK----LQEELDKYSQA 837
+++ +E ++LEE ++L + + E+ ++ S++ QE K QA
Sbjct: 1994 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053
Query: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASE 897
K +++K++ L ++ + ++L E R A A+ + + E A
Sbjct: 2054 EEKAHAF--AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2111
Query: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Q+ EE + ++ E+Q Q++ Q + ++ +KE ++ + Q +
Sbjct: 2112 RRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2163
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDI--------QTDNSDIFQETKVQSLNIENGSE 1009
D E++ +K EQ Q + Q++ +TD+ + ++Q L E
Sbjct: 2164 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2223
Query: 1010 KHDLSKAETERLVKGIKERE---LEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQQ 1063
S+ E E ++ E L+ ++ E + + D + +E K+ Q+ ++
Sbjct: 2224 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2283
Query: 1064 -KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
L + A A +D+ QQ+ A M +EK+ AV +E + LK E +
Sbjct: 2284 AARLSVAAQEAARLRQLAEEDLA--QQRALAEKMLKEKMQAV-----QEATRLKAEAELL 2336
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKC 1180
KE A Q++ ++L E Q + ET Q R++ +E+ A +++
Sbjct: 2337 QQ---QKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2389
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+ +A + + E + ++ +++ +++ + E Q+ +T VQ ++ +
Sbjct: 2390 KLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2443
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Q + +L+ + KLQ + L ++S E + + QE +Q S
Sbjct: 2444 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS---FL 2500
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK----S 1355
+ KD LL + I + + L +K++ L E + QQ++E+ R+ S
Sbjct: 2501 SEKDSLLQRERFIEQEKAKLEQLFQD-----EVAKAQQLREEQQRQQQQMEQERQRLVAS 2555
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++E +E R + + + R++ E E ++L+E+ +LL+E+
Sbjct: 2556 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ----LQLLEEQHRA 2611
Query: 1416 IKAKSDQLLSS 1426
A S+++ +S
Sbjct: 2612 ALAHSEEVTAS 2622
Score = 128 bits (322), Expect = 5e-29
Identities = 319/1545 (20%), Positives = 631/1545 (40%), Gaps = 244/1545 (15%)
Query: 467 SELHDLRLNLEAKE----------------QELNQSISEKETLIAEIEELD----RQNQE 506
SEL D+RL LEA E +E Q I+E++ AE+E L R + E
Sbjct: 991 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1050
Query: 507 ATKHMILIKDQLSKQ--QNEGDSIISKLKQDLN------DEKKRVHQLEDDKMDITKELD 558
A K + L + + ++E + + KL+Q + ++ K + + + L
Sbjct: 1051 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1110
Query: 559 VQKEKLIQSE---VALNDLHLTKQKL----------EDKVENLVDQLNKSQESNVSIQKE 605
+E+L +++ L +L TK L + + L D+L +QE +Q+
Sbjct: 1111 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1170
Query: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQN-------L 658
+ E + + E ++++ L Q ++ + L++ ++R +++ L
Sbjct: 1171 HGERDVEVERWRERVAQLLERWQAVLAQ---TDVRQRELEQLGRQLRYYRESADPLGAWL 1227
Query: 659 SELEQLNENLKKVAF-DVKMENEKL----VLACEDVRH--QLEECLAGNNQLSLEKNTIV 711
+ + E ++ + D + E+L L E RH ++EEC Q
Sbjct: 1228 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1287
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
L K ++E AKK ++ + E I+E + R + L ++ IK +
Sbjct: 1288 LQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQY-IKFISET 1344
Query: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK-LKERSSKLQEE 830
+ E ++ EQ + +E + ++LE+Q+QL + + + E+ KE ++QEE
Sbjct: 1345 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1404
Query: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ----EELERLR---EEQSRTAPVA 883
+ + +A + +++I+E+ + L E + E ER R EE+ R +
Sbjct: 1405 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1464
Query: 884 DPKT-------LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL--- 933
T + L + + K +EE + ++ ++D++Q K Q L
Sbjct: 1465 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524
Query: 934 -----------QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK-SLQKTIEQIKTQLHE 981
Q + ++E R Q E+ Q +E+ +++ +L+ + +L
Sbjct: 1525 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1584
Query: 982 ERQDIQTDNSDI---FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELE------- 1031
+R + + QE V + +E+ +AE ER + ERELE
Sbjct: 1585 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER-AREEAERELERWQLKAN 1643
Query: 1032 --IKL-LNEKNISLTKQIDQL----SKDEV-------GKL-TQIIQQKDLEIQALHARIS 1076
++L L + ++ K + Q K+E GK Q ++Q++L Q L +
Sbjct: 1644 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1703
Query: 1077 STSHT--------QDVVYL-------QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 1121
T Q+++ L +QQ Q E ++ T++ L+ E K
Sbjct: 1704 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1763
Query: 1122 ----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI-------IREKD 1170
M ++A+K A + + ++K R E+ FRE + +R+ R++
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAEEAARLRALAEEAKRQRQ 1822
Query: 1171 I-EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM--EEWKQQ 1227
+ E DA Q+ + + + + EA + + + E L+E++ ++++++ +E Q+
Sbjct: 1823 LAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDEAFQR 1881
Query: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Q QH+ A ++E L QL+ + + L D + E+ LK ++
Sbjct: 1882 RRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1940
Query: 1288 L----AQVQHSIGQL-CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
A+++ +G++ N +D L K +L +A + E R ++E + S
Sbjct: 1941 AAAGKAELELELGRIRSNAEDTLRSK---EQAELEAARQRQLAAEEERRRREAEERVQKS 1997
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS---------------ELERKE 1387
++E RK+ E+ ++ E RL + S + E K
Sbjct: 1998 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2057
Query: 1388 H----EQTDSEIKQ-LKEKQDVLQKLLKEKDLLIKAKSD------QLLSSNENFTNKVNE 1436
H +Q + E++Q L+++Q VL +L E + +A + Q +V E
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2117
Query: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
E L+Q+ + + KL+ E E+ E R + E AL++ + M + K
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHK 2175
Query: 1497 EFECHSMKEKALAFEQL--LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV--MLA 1552
+F ++++KA ++L L+ + + + N L ++ ++ + ++R QV L
Sbjct: 2176 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2235
Query: 1553 LKQKQMENTA-------LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED- 1604
+ QME + +N LRDK+ + + L+ + + + R ++AA++
Sbjct: 2236 SVRVQMEELSKLKARIEAENRALILRDKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2294
Query: 1605 ------REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
E L ++ + E+ L A++ A+ + + E LQ+Q + +Q A +
Sbjct: 2295 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQEQ----ARR 2349
Query: 1659 LSVSQEQV-KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW-------KKNAE 1710
L +EQ+ +Q A Q LE +Q + M SAE E+ K +AE +++A+
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQ 2408
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ-----------IEELKRQNE---- 1755
+ + E L A L + L+++ +Q I EL+R+ E
Sbjct: 2409 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2468
Query: 1756 ------LRQEMLDDVQKKLM-----SLANSSEGKVDKVLMRNLFI 1789
L+ E + VQ++ + +L S + D +L R FI
Sbjct: 2469 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2513
Score = 119 bits (298), Expect = 3e-26
Identities = 237/1253 (18%), Positives = 497/1253 (39%), Gaps = 200/1253 (15%)
Query: 586 ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
+ L+ L + + Q+ ELK+ Q E +R + L L+++ + +
Sbjct: 970 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1029
Query: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL------ACEDVRHQLEECLAG 699
+++A+ +E+E L + + +++ E EK++ A +R +LE L
Sbjct: 1030 QQKAQ--------AEVEGLGKGVARLS----AEAEKVLALPEPSPAAPTLRSELELTLGK 1077
Query: 700 NNQLSLEKNTIVETLKMEKGEIEA-----ELCWAKKRLLEEANKYEKTIEELSNARNLNT 754
Q+ +E LK I E+ A + L+EA T+ EL +
Sbjct: 1078 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK---- 1133
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ +L+ E +D L + E ++L Q +++
Sbjct: 1134 ------------------ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1175
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE--RL 872
+ +E+ +ER ++L L+++ L + ++ ++ +E+ R L +E + L L+ R
Sbjct: 1176 VEVERWRERVAQL---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1232
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
R+EQ + P+AD + + QL + LEE +H +K+ E Q +K Q + +
Sbjct: 1233 RQEQIQAMPLADSQAVRE---------QLRQEQALLEEIERHGEKVEECQRFAK-QYINA 1282
Query: 933 LQEQKKEMDEFRYQHE-----------------------QMNATHTQLFLEKDEEIKSLQ 969
+++ + ++ ++ Q E + +++L + IK +
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1342
Query: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
+T+ +++ + Q + + + E + +E H +KA+ ER K +++R
Sbjct: 1343 ETLRRMEEEERLAEQQ-RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1401
Query: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
E +++ + ++ Q + S E +L Q+ Q + EIQA + + ++ + +++
Sbjct: 1402 QE-EVVRREEAAVDAQQQKRSIQE--ELQQLRQSSEAEIQAKARQAEAAERSR--LRIEE 1456
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+++ ++ E R+ + E + EA + Q+E ++L + +
Sbjct: 1457 EIRVVRLQLEAT-------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1509
Query: 1150 SGQDMFRETIQNLSRI------IREKDIEIDALSQ------------------KCQTLLA 1185
Q + ++ SR+ REK + AL + + + +
Sbjct: 1510 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1569
Query: 1186 VLQTSSTGNEAG--------GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
L+T+ EA + Q E LQE Q+++ E + Q + +
Sbjct: 1570 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1629
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
E A+ + E QL+A + +LQ + +S Q E + ++ + + +
Sbjct: 1630 E-AERELERWQLKANEAL----RLRLQAEEVAQQKSLAQAEAE-----KQKEEAEREARR 1679
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
++ + + ++ +L L +A+ A+ +QEL LR +
Sbjct: 1680 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA------------EQELIRLRAETE 1727
Query: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL---QKLLKEKDL 1414
+ + + L+E RL AA ++ + ++ ++E+ +++ + +VL + +E+
Sbjct: 1728 QGEQQRQLLEEELARLQREAAAATQ----KRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Query: 1415 LIKAKSDQLLSSNEN-FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIV---- 1469
KS Q L + F E LR K + + E D + + E E+++
Sbjct: 1784 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1843
Query: 1470 ----ETYRGKETEYQALQET---NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
E R K AL+E N + + ++ F+ ++E+A + ++E+
Sbjct: 1844 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1903
Query: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
+ L K + E T+ +++ ++ +LALK + A + E++ L RSN E
Sbjct: 1904 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE-LELGRIRSNAEDT 1962
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
E E + R+ A E+R + EE++ S A E A+ Q +E ++
Sbjct: 1963 LRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQRKAALEEVE 2016
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
+ +K + L+ QE +Q L A+ QK+L
Sbjct: 2017 R---LKAKVEEARRLRERAEQESARQLQL---------------------AQEAAQKRLQ 2052
Query: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNE 1755
AE K +A ++ K LQ+ L + + LD E E+ EE + Q E
Sbjct: 2053 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2105
Score = 92.8 bits (229), Expect = 3e-18
Identities = 131/757 (17%), Positives = 311/757 (41%), Gaps = 65/757 (8%)
Query: 41 GTEEVEAELPDSRTKEIEAIHAILRSENE--RLKKLCTDLEEKHEASEIQIKQQSTSYRN 98
G E+E EL R+ + + + ++E E R ++L + E + +E ++++ +
Sbjct: 1944 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2003
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+Q++ + ++ + +++ + A Q + A H A
Sbjct: 2004 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2063
Query: 159 DDDMDFGDIISSQQEI-NRLSNEVS---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+ + + +Q + ++L E R E R A+ AQ +++E
Sbjct: 2064 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE---- 2119
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
LKQ+ ++ + + ++ E +RR + E + ++ + + +
Sbjct: 2120 -----RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEME 2172
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
E L + ++++ + L+++ E+ + L+++++ + + + A R +
Sbjct: 2173 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2232
Query: 335 EQEQLNVEKRQIME-----ECENLKLECSK-------LQPSAVKQSDTMTEKERILAQSA 382
E + V+ ++ + E EN L LQ A K E R+ S
Sbjct: 2233 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL---SV 2289
Query: 383 SVEEVFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL------- 433
+ +E RL+Q + A+ + L + ++ +LK E+L+++K L
Sbjct: 2290 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2349
Query: 434 LSQEKEELQMSLLKLNNEYE-VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
L ++KE++ L + ++ +++ R + + +E RL L E Q+ +E++
Sbjct: 2350 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE--RLKLRVAEMSRAQARAEEDA 2407
Query: 493 L-----IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---DLNDEKKRVH 544
EI E + + AT+ + + L Q+ + D +L++ +L EK+++
Sbjct: 2408 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2467
Query: 545 QLEDDKMDITKE--LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSI 602
Q E + + E VQ+E+L+Q AL L+++ + E ++Q E
Sbjct: 2468 Q-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2526
Query: 603 QKENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+ + L+E ++ ++++ + R L+ S+ + ++ EAE +++ EL
Sbjct: 2527 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR--------RQHEAE-EGVRRKQEEL 2577
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
+QL + ++ + EN++L + + Q LA + +++ + +TL + +
Sbjct: 2578 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2637
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+ A+ + + + + + L A L+ LQ
Sbjct: 2638 DGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2674
Score = 83.2 bits (204), Expect = 2e-15
Identities = 194/1114 (17%), Positives = 417/1114 (37%), Gaps = 196/1114 (17%)
Query: 734 EEANKYEKTIEELSNARNLNTSALQLEHEHLIKL----------------NQKKDMEIAE 777
+E ++ ++ I EL + R L A + H ++L QK E+
Sbjct: 981 QEESRCQRCISELKDIR-LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1039
Query: 778 LKKNIEQMDTDHKET---------KDVLSSSLE-EQKQLTQLINKKEIFIEKLKERSSKL 827
L K + ++ + ++ L S LE +L Q+ + I++EKLK S +
Sbjct: 1040 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1099
Query: 828 ------QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
+E L + + L++ + + T+ E + + S+K +LR + P
Sbjct: 1100 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-----------KLRAQAEAQQP 1148
Query: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
D L E+ + E L++ +E + QLL+ Q + D
Sbjct: 1149 TFDA--------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1200
Query: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE-ERQDIQTDNSDIFQETKVQ 1000
+ + EQ+ + + E + + + + + + Q+ D Q + QE +
Sbjct: 1201 VRQRELEQLGR-QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1259
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
IE EK + + ++ + IK+ EL++ + L K +V ++
Sbjct: 1260 E-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1315
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
+ Q+ ++++ ++ +++ + +Q + ++ + L+ E E+ + ++
Sbjct: 1316 VIQEYVDLRTHYSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1374
Query: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
K + A A + + E K+L R + ++R ++ +DA
Sbjct: 1375 KQRQLAEAHAQAKAQAEREAKELQQRMQEE--------------VVRREEAAVDA----- 1415
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+QQ + ++E QQ+ Q A
Sbjct: 1416 ----------------------------------QQQKRSIQEELQQLR------QSSEA 1435
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
++Q + Q +A S+L+++ + + T+ + G E
Sbjct: 1436 EIQAKARQAEAA------ERSRLRIEEEIRVVRLQLEATERQRGGAE------------- 1476
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
G+L + + A Q+ E + +V ES Q E+E + E +
Sbjct: 1477 ------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1530
Query: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
A +E L + E E +E+++ ++ Q L+ + + +++K
Sbjct: 1531 AA----REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1586
Query: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
+ E + AV L+E + + ++ E R +E +
Sbjct: 1587 ASFAEKTAQLERSLQEEHV---AVAQLRE----------EAERRAQQQAEAERAREEAER 1633
Query: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
L+ +K + LR + ++K+LA + K+KE+ + + ++++++ +
Sbjct: 1634 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1693
Query: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Q+ Q LA Q + A + E+ RLR + + Q+ + L L + REA
Sbjct: 1694 AEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ----REAA 1748
Query: 1601 AA----EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
AA ++ EA+L K +E L S + A E + + + L+ + + +E A
Sbjct: 1749 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1808
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK--QKQLIAEWKKNAENLEG 1714
++++E +Q L+ +E+ A AE E+ ++L A + E
Sbjct: 1809 RLRALAEEAKRQRQLA------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1856
Query: 1715 KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
++ L E A + RL E + ++EE Q++ D++++L L +
Sbjct: 1857 EI-----ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA------DIEERLAQLRKA 1905
Query: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGS 1808
S+ ++++ + L + E+L L S
Sbjct: 1906 SDSELER--QKGLVEDTLRQRRQVEEEILALKAS 1937
Score = 70.1 bits (170), Expect = 2e-11
Identities = 268/1447 (18%), Positives = 557/1447 (38%), Gaps = 159/1447 (10%)
Query: 474 LNLEAKEQELNQSISEKET-LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
L++E + +L+ +I E+E L +E E L+ + TK + + +Q N+ D+++
Sbjct: 368 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTK-LQMEAGLCEEQLNQADALLQSD 426
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ L K + ++ ++LD + + +I+ + ND+ K + E + ++
Sbjct: 427 VRLLAAGK-----VPQRAGEVERDLD-KADSMIR--LLFNDVQTLKDGRHPQGEQMYRRV 478
Query: 593 NKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLK---- 645
+ E V+I+ E NL LK + +++++ + +Q + DS + LL
Sbjct: 479 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEE 538
Query: 646 --------EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
E ++ +++ L L++++++ ++ R +CL
Sbjct: 539 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL 598
Query: 698 AGNNQLSLEKNTIVETLKMEKGEIEAE---LCWAKKRLLEEANKYEKTIEELSNARNLNT 754
+L L+ ++ + K +E+ + A K L+ K E+ + + RN N
Sbjct: 599 G---RLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNM 655
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQM-DTDHKETKDVLSSSLEEQKQLTQLINKK 813
+A + + L++ + K+ +I EL+ +++ DH V S Q Q + ++
Sbjct: 656 TAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLC 715
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
LKE ++ Q D ++E LQ+ E LR
Sbjct: 716 CCIEAHLKENAAYFQFFSD-------------------------VREAEGQLQKLQEALR 750
Query: 874 EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE-------DQNQSK 926
+ S + D + + E QLN K HL K + +++ + +
Sbjct: 751 RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 810
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQM------------------NATHTQLFL------EKD 962
+ LL ++ E+ + Q+ A + FL E
Sbjct: 811 LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 870
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
E + L+ + + T H+ D+++ + VQ + + + L K E +R
Sbjct: 871 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTL-KPEEQRQA 929
Query: 1023 KGIKERELEIKLLNEKNISLTKQIDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHT 1081
E + L + ++ D+L ++ E G + QQ +Q+L S
Sbjct: 930 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRC 986
Query: 1082 QDVV--YLQQQLQAYAMEREKVFAVL----NEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Q + +LQ A E V + E RE + E K V + +
Sbjct: 987 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1046
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS----QKCQTLLAVLQTSS 1191
L E +K+ E S T+++ + K ++ +LS +K +T+ V++ +
Sbjct: 1047 LSAEAEKVLALPEPSPA---APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1103
Query: 1192 TGNEAGGVNSNQFEE------LLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
E + Q +E L E + K +KK+ + T ++ E QE
Sbjct: 1104 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1163
Query: 1246 LHQLQ-------AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
+LQ +V + ++L + ++ + + +L+ G++L + S L
Sbjct: 1164 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1223
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSA-ECLRASKSEVLSESSELLQQELEELRKSLQ 1357
L Q+ + L Q+ E LR + + L E E +++EE ++ +
Sbjct: 1224 ----GAWLQDARRRQEQIQAMPLADSQAVREQLR--QEQALLEEIERHGEKVEECQRFAK 1277
Query: 1358 EKDATIR--TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+ I+ LQ ++ A+ + K ++S I++ + + +L
Sbjct: 1278 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1337
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
IK S+ L E E L Q +ER+ +E + K + E +
Sbjct: 1338 IKFISETLRRMEE-------EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1390
Query: 1476 ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
E E + LQ+ + ++R +E + ++K + ++ L++ Q E+ ++
Sbjct: 1391 EREAKELQQRMQE--EVVRREEAAVDAQQQKR-SIQEELQQLRQSSEAEIQAKARQAEAA 1447
Query: 1536 QEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRNHL 1588
+ + ++E V L L+ + + + E+Q LR + + ++ +E ERLR +
Sbjct: 1448 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1507
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
+D R+ A + ++++ + EK + A+E QA + E Q V
Sbjct: 1508 ---QDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQAE-EAERRLRQAEVE 1562
Query: 1649 SKQRDETALQLS--VSQEQVKQYALSLANLQMVLEHFQQEEK---AMYSAELEKQKQLIA 1703
++ + AL+ + ++ +++ S A LE QEE A E E++ Q A
Sbjct: 1563 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1622
Query: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
E ++ E E ++ Q +EA A + +Q + + + E+ K + E
Sbjct: 1623 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1682
Query: 1764 VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHD 1823
+++ + +E +++K R L G E++RL + E+ QL +
Sbjct: 1683 AEEQAVRQRELAEQELEK--QRQLAEGTAQQRLAAEQELIRLRAET--EQGEQQRQLLEE 1738
Query: 1824 DQGGVTR 1830
+ + R
Sbjct: 1739 ELARLQR 1745
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 178 bits (452), Expect = 4e-44
Identities = 346/1697 (20%), Positives = 687/1697 (40%), Gaps = 229/1697 (13%)
Query: 170 SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS-------EICKLQNIIKELK 222
+Q E+ L V+RL +E + + S A T S+ ++ L I E
Sbjct: 1029 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1088
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET 282
+ S I Q VL+ AH+++L E ++ L + E L+ L Q +
Sbjct: 1089 KTISLVIRGTQGAEEVLR-AHEEQLKE-AQAVPATLPELEATKASLKKLRAQAEAQQPTF 1146
Query: 283 DL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
D ++ Q+ + LQ E ++E+ +++ + ++ + D+ +RE EQL
Sbjct: 1147 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1206
Query: 341 VEKRQIMEECENL-----KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395
+ R E + L + Q A+ +D+ +E++ + A +EE+ R + +
Sbjct: 1207 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1266
Query: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455
+ + + + +D L K ++ +K + E + + L Y +
Sbjct: 1267 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1326
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILI 514
+ ++ I SE LR +E +E+ Q +E+ +AE+E L++Q Q A H
Sbjct: 1327 TTLTSQYIKFISET--LR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA--- 1380
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+K Q E ++ +L+Q + +E R + D Q+++ IQ E L
Sbjct: 1381 ---QAKAQAEREA--KELQQRMQEEVVRREEAAVDAQ--------QQKRSIQEE-----L 1422
Query: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD 634
+Q E +++ Q ++ S + I++E ++ + E + EL +
Sbjct: 1423 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1482
Query: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDVR 690
+ + +E +R Q+ S+ ++ E + K + E ++ + A E++R
Sbjct: 1483 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1542
Query: 691 HQLEECLAGNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
Q EE Q +E+ V+ L+ + EAEL + E+ + E++++E
Sbjct: 1543 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE--- 1599
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIA--ELKKNIE--QMDTDHKETKDVLSSSLEEQKQ 805
+ + QL E + Q+ + E A E ++ +E Q+ + + + + +QK
Sbjct: 1600 ---HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656
Query: 806 LTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
L Q K++ E+ R K +E QA+R+ E+ Q +E++ + ++
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLA 1710
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
++EL RLR E TE + QL LEEE+ Q+ Q
Sbjct: 1711 AEQELIRLRAE----------------TEQGEQQRQL------LEEELARLQREAAAATQ 1748
Query: 925 SKMQLLQSLQEQKKEMD-----EFRYQHEQMNATHTQL---------FLEKDEEIKSLQK 970
+ +L L + + EM+ + R + E + + F E EE L+
Sbjct: 1749 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1808
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
E+ K Q +D Q + + + E + + ++ +TE + +KE+E
Sbjct: 1809 LAEEAKRQRQLAEEDAAR------QRAEAERVLAEKLAAIGEATRLKTEAEI-ALKEKEA 1861
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
E +++ +L++DE Q++ LE QA H D+ Q
Sbjct: 1862 E-----------NERLRRLAEDEA------FQRRRLEEQA-------AQHKADIEERLAQ 1897
Query: 1091 LQ-AYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
L+ A E E+ ++ + R+ ++ E ++ + A+ E A + +L R S
Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEE---ILALKASFEKAAAGKAELELELG-RIRS 1953
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+ +D R Q R++ + + ++ + V ++ + EA + Q + L+
Sbjct: 1954 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA----ARQRKAALE 2009
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTG 1269
E ++LK +V++ +++ QE QLQ L +LQ +
Sbjct: 2010 EVERLKAKVEEARRLRERAE-------------QESARQLQ---LAQEAAQKRLQAEEKA 2053
Query: 1270 LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD------IISPQLSSASLLT 1323
+ +Q E +L+ Q L Q Q + QL + + + + + ++ S
Sbjct: 2054 HAFAVQQKEQELQ---QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2110
Query: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
+ AE L+ S E ++ Q E+LRK +++ A R Q L AA +E+
Sbjct: 2111 VEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEM 2167
Query: 1384 ER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
E+ K EQT + Q++++ L+ L+E D ++L T + +
Sbjct: 2168 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2227
Query: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE------ 1495
+ + +++ ++ L +++ EN ++ R K+ + LQE K + E
Sbjct: 2228 EELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2285
Query: 1496 --------KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER- 1546
++ + ++ E++LKEK Q A Q+K + +Q R
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 1547 ---DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
D+ +A +Q E Q ++ R ++ + E ERL+ + E + R AE
Sbjct: 2346 LQEDKEQMA-QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR----AE 2400
Query: 1604 DREAKLRKKVTVLEEKL----------VSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
+ + RK+ + EKL V+ +E Q+ E L+E + + ++++
Sbjct: 2401 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2460
Query: 1654 ETA-----LQL------SVSQEQV-------KQYALSLANLQMVLEHFQQEEKA----MY 1691
+ LQL +V QEQ+ +Q LS + + E F ++EKA ++
Sbjct: 2461 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2520
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
E+ K +QL E ++ + +E + L ++EA A + + +Q+E+ +
Sbjct: 2521 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2580
Query: 1752 RQNELRQEMLDDVQKKL 1768
RQ E E+L + ++L
Sbjct: 2581 RQQE---ELLAEENQRL 2594
Score = 159 bits (402), Expect = 3e-38
Identities = 292/1451 (20%), Positives = 593/1451 (40%), Gaps = 171/1451 (11%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHE 83
A L S K + G+E V E D RT E L + + K ++ + E
Sbjct: 1291 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTTLTSQYIKFISETLRRME 1345
Query: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
E +QQ R +L EVE + K RQ+A K Q+ ++ +
Sbjct: 1346 EEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1403
Query: 144 SSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL----ESEVGHWRHIAQTSK 199
A + +QQ+ + E+ +L E+E+ A+ ++
Sbjct: 1404 REEA-------------------AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1444
Query: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
++ + +LQ E ++ ++ + A +++ E + R R ++
Sbjct: 1445 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1504
Query: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ---IEKVESTKKMEQLE-DKI 315
D +R + E L + ++ + E Q+ +Q L+ ++ E+ +++ Q E ++
Sbjct: 1505 DESQRKRQAEVEL----ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1560
Query: 316 KDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+ + L +A+ R + +L ++ E+ L+ LQ V + E E
Sbjct: 1561 RQVQVALETAQ------RSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAE 1611
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R Q A E +A +AE E+ R A + L+L+++ E + ++KSL
Sbjct: 1612 RRAQQQAEAE------RAREEAERELERWQLK------ANEALRLRLQAEEVAQQKSLAQ 1659
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISL-DSELHDLRLNLEAKEQELNQSISEKETLI 494
E E+ + + + A R L + EL R E Q+ + E L
Sbjct: 1660 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1719
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
AE E+ ++Q Q L++++L++ Q E + K +Q+L E +V
Sbjct: 1720 AETEQGEQQRQ-------LLEEELARLQREAAAATQK-RQELEAELAKVR---------- 1761
Query: 555 KELDVQKEKLIQSEV-ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
+ E L+ S+ A + T +K + ++E + + E ++ E K
Sbjct: 1762 ----AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1817
Query: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
+ EE+ +R R E + L + + + T LK EAE+ LK+ +E NE L+++A
Sbjct: 1818 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIA-LKEKEAE----NERLRRLAE 1871
Query: 674 DVKMENEKLVLACEDVRHQLEECL-----AGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
D + +L + +EE L A +++L +K + +TL+ ++ ++E E+ A
Sbjct: 1872 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEEEIL-A 1929
Query: 729 KKRLLEEANKYEKTIE-ELSNARNLNTSAL------QLEHEHLIKLNQKKDMEIAELKKN 781
K E+A + +E EL R+ L +LE +L +++ E ++
Sbjct: 1930 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1989
Query: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSK----LQEELDKYSQA 837
+++ +E ++LEE ++L + + E+ ++ S++ QE K QA
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASE 897
K +++K++ L ++ + ++L E R A A+ + + E A
Sbjct: 2050 EEKAHAF--AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2107
Query: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Q+ EE + ++ E+Q Q++ Q + ++ +KE ++ + Q +
Sbjct: 2108 RRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2159
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDI--------QTDNSDIFQETKVQSLNIENGSE 1009
D E++ +K EQ Q + Q++ +TD+ + ++Q L E
Sbjct: 2160 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2219
Query: 1010 KHDLSKAETERLVKGIKERE---LEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQQ 1063
S+ E E ++ E L+ ++ E + + D + +E K+ Q+ ++
Sbjct: 2220 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2279
Query: 1064 -KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
L + A A +D+ QQ+ A M +EK+ AV +E + LK E +
Sbjct: 2280 AARLSVAAQEAARLRQLAEEDLA--QQRALAEKMLKEKMQAV-----QEATRLKAEAELL 2332
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKC 1180
KE A Q++ ++L E Q + ET Q R++ +E+ A +++
Sbjct: 2333 QQ---QKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2385
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+ +A + + E + ++ +++ +++ + E Q+ +T VQ ++ +
Sbjct: 2386 KLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2439
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Q + +L+ + KLQ + L ++S E + + QE +Q S
Sbjct: 2440 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS---FL 2496
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK----S 1355
+ KD LL + I + + L +K++ L E + QQ++E+ R+ S
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQD-----EVAKAQQLREEQQRQQQQMEQERQRLVAS 2551
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++E +E R + + + R++ E E ++L+E+ +LL+E+
Sbjct: 2552 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ----LQLLEEQHRA 2607
Query: 1416 IKAKSDQLLSS 1426
A S+++ +S
Sbjct: 2608 ALAHSEEVTAS 2618
Score = 128 bits (322), Expect = 5e-29
Identities = 319/1545 (20%), Positives = 631/1545 (40%), Gaps = 244/1545 (15%)
Query: 467 SELHDLRLNLEAKE----------------QELNQSISEKETLIAEIEELD----RQNQE 506
SEL D+RL LEA E +E Q I+E++ AE+E L R + E
Sbjct: 987 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1046
Query: 507 ATKHMILIKDQLSKQ--QNEGDSIISKLKQDLN------DEKKRVHQLEDDKMDITKELD 558
A K + L + + ++E + + KL+Q + ++ K + + + L
Sbjct: 1047 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1106
Query: 559 VQKEKLIQSE---VALNDLHLTKQKL----------EDKVENLVDQLNKSQESNVSIQKE 605
+E+L +++ L +L TK L + + L D+L +QE +Q+
Sbjct: 1107 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1166
Query: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQN-------L 658
+ E + + E ++++ L Q ++ + L++ ++R +++ L
Sbjct: 1167 HGERDVEVERWRERVAQLLERWQAVLAQ---TDVRQRELEQLGRQLRYYRESADPLGAWL 1223
Query: 659 SELEQLNENLKKVAF-DVKMENEKL----VLACEDVRH--QLEECLAGNNQLSLEKNTIV 711
+ + E ++ + D + E+L L E RH ++EEC Q
Sbjct: 1224 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1283
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
L K ++E AKK ++ + E I+E + R + L ++ IK +
Sbjct: 1284 LQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQY-IKFISET 1340
Query: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK-LKERSSKLQEE 830
+ E ++ EQ + +E + ++LE+Q+QL + + + E+ KE ++QEE
Sbjct: 1341 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1400
Query: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ----EELERLR---EEQSRTAPVA 883
+ + +A + +++I+E+ + L E + E ER R EE+ R +
Sbjct: 1401 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1460
Query: 884 DPKT-------LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL--- 933
T + L + + K +EE + ++ ++D++Q K Q L
Sbjct: 1461 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
Query: 934 -----------QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK-SLQKTIEQIKTQLHE 981
Q + ++E R Q E+ Q +E+ +++ +L+ + +L
Sbjct: 1521 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1580
Query: 982 ERQDIQTDNSDI---FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELE------- 1031
+R + + QE V + +E+ +AE ER + ERELE
Sbjct: 1581 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER-AREEAERELERWQLKAN 1639
Query: 1032 --IKL-LNEKNISLTKQIDQL----SKDEV-------GKL-TQIIQQKDLEIQALHARIS 1076
++L L + ++ K + Q K+E GK Q ++Q++L Q L +
Sbjct: 1640 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1699
Query: 1077 STSHT--------QDVVYL-------QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 1121
T Q+++ L +QQ Q E ++ T++ L+ E K
Sbjct: 1700 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1759
Query: 1122 ----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI-------IREKD 1170
M ++A+K A + + ++K R E+ FRE + +R+ R++
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAEEAARLRALAEEAKRQRQ 1818
Query: 1171 I-EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM--EEWKQQ 1227
+ E DA Q+ + + + + EA + + + E L+E++ ++++++ +E Q+
Sbjct: 1819 LAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDEAFQR 1877
Query: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Q QH+ A ++E L QL+ + + L D + E+ LK ++
Sbjct: 1878 RRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 1288 L----AQVQHSIGQL-CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
A+++ +G++ N +D L K +L +A + E R ++E + S
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSK---EQAELEAARQRQLAAEEERRRREAEERVQKS 1993
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS---------------ELERKE 1387
++E RK+ E+ ++ E RL + S + E K
Sbjct: 1994 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2053
Query: 1388 H----EQTDSEIKQ-LKEKQDVLQKLLKEKDLLIKAKSD------QLLSSNENFTNKVNE 1436
H +Q + E++Q L+++Q VL +L E + +A + Q +V E
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2113
Query: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
E L+Q+ + + KL+ E E+ E R + E AL++ + M + K
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHK 2171
Query: 1497 EFECHSMKEKALAFEQL--LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV--MLA 1552
+F ++++KA ++L L+ + + + N L ++ ++ + ++R QV L
Sbjct: 2172 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2231
Query: 1553 LKQKQMENTA-------LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED- 1604
+ QME + +N LRDK+ + + L+ + + + R ++AA++
Sbjct: 2232 SVRVQMEELSKLKARIEAENRALILRDKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2290
Query: 1605 ------REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
E L ++ + E+ L A++ A+ + + E LQ+Q + +Q A +
Sbjct: 2291 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQEQ----ARR 2345
Query: 1659 LSVSQEQV-KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW-------KKNAE 1710
L +EQ+ +Q A Q LE +Q + M SAE E+ K +AE +++A+
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQ 2404
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ-----------IEELKRQNE---- 1755
+ + E L A L + L+++ +Q I EL+R+ E
Sbjct: 2405 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2464
Query: 1756 ------LRQEMLDDVQKKLM-----SLANSSEGKVDKVLMRNLFI 1789
L+ E + VQ++ + +L S + D +L R FI
Sbjct: 2465 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2509
Score = 119 bits (298), Expect = 3e-26
Identities = 237/1253 (18%), Positives = 497/1253 (39%), Gaps = 200/1253 (15%)
Query: 586 ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
+ L+ L + + Q+ ELK+ Q E +R + L L+++ + +
Sbjct: 966 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1025
Query: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL------ACEDVRHQLEECLAG 699
+++A+ +E+E L + + +++ E EK++ A +R +LE L
Sbjct: 1026 QQKAQ--------AEVEGLGKGVARLS----AEAEKVLALPEPSPAAPTLRSELELTLGK 1073
Query: 700 NNQLSLEKNTIVETLKMEKGEIEA-----ELCWAKKRLLEEANKYEKTIEELSNARNLNT 754
Q+ +E LK I E+ A + L+EA T+ EL +
Sbjct: 1074 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK---- 1129
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ +L+ E +D L + E ++L Q +++
Sbjct: 1130 ------------------ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1171
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE--RL 872
+ +E+ +ER ++L L+++ L + ++ ++ +E+ R L +E + L L+ R
Sbjct: 1172 VEVERWRERVAQL---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1228
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
R+EQ + P+AD + + QL + LEE +H +K+ E Q +K Q + +
Sbjct: 1229 RQEQIQAMPLADSQAVRE---------QLRQEQALLEEIERHGEKVEECQRFAK-QYINA 1278
Query: 933 LQEQKKEMDEFRYQHE-----------------------QMNATHTQLFLEKDEEIKSLQ 969
+++ + ++ ++ Q E + +++L + IK +
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1338
Query: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
+T+ +++ + Q + + + E + +E H +KA+ ER K +++R
Sbjct: 1339 ETLRRMEEEERLAEQQ-RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1397
Query: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
E +++ + ++ Q + S E +L Q+ Q + EIQA + + ++ + +++
Sbjct: 1398 QE-EVVRREEAAVDAQQQKRSIQE--ELQQLRQSSEAEIQAKARQAEAAERSR--LRIEE 1452
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+++ ++ E R+ + E + EA + Q+E ++L + +
Sbjct: 1453 EIRVVRLQLEAT-------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1505
Query: 1150 SGQDMFRETIQNLSRI------IREKDIEIDALSQ------------------KCQTLLA 1185
Q + ++ SR+ REK + AL + + + +
Sbjct: 1506 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1565
Query: 1186 VLQTSSTGNEAG--------GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
L+T+ EA + Q E LQE Q+++ E + Q + +
Sbjct: 1566 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1625
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
E A+ + E QL+A + +LQ + +S Q E + ++ + + +
Sbjct: 1626 E-AERELERWQLKANEAL----RLRLQAEEVAQQKSLAQAEAE-----KQKEEAEREARR 1675
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
++ + + ++ +L L +A+ A+ +QEL LR +
Sbjct: 1676 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA------------EQELIRLRAETE 1723
Query: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL---QKLLKEKDL 1414
+ + + L+E RL AA ++ + ++ ++E+ +++ + +VL + +E+
Sbjct: 1724 QGEQQRQLLEEELARLQREAAAATQ----KRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Query: 1415 LIKAKSDQLLSSNEN-FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIV---- 1469
KS Q L + F E LR K + + E D + + E E+++
Sbjct: 1780 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1839
Query: 1470 ----ETYRGKETEYQALQET---NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
E R K AL+E N + + ++ F+ ++E+A + ++E+
Sbjct: 1840 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1899
Query: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
+ L K + E T+ +++ ++ +LALK + A + E++ L RSN E
Sbjct: 1900 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE-LELGRIRSNAEDT 1958
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
E E + R+ A E+R + EE++ S A E A+ Q +E ++
Sbjct: 1959 LRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQRKAALEEVE 2012
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
+ +K + L+ QE +Q L A+ QK+L
Sbjct: 2013 R---LKAKVEEARRLRERAEQESARQLQL---------------------AQEAAQKRLQ 2048
Query: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNE 1755
AE K +A ++ K LQ+ L + + LD E E+ EE + Q E
Sbjct: 2049 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2101
Score = 92.8 bits (229), Expect = 3e-18
Identities = 131/757 (17%), Positives = 311/757 (41%), Gaps = 65/757 (8%)
Query: 41 GTEEVEAELPDSRTKEIEAIHAILRSENE--RLKKLCTDLEEKHEASEIQIKQQSTSYRN 98
G E+E EL R+ + + + ++E E R ++L + E + +E ++++ +
Sbjct: 1940 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1999
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+Q++ + ++ + +++ + A Q + A H A
Sbjct: 2000 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2059
Query: 159 DDDMDFGDIISSQQEI-NRLSNEVS---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+ + + +Q + ++L E R E R A+ AQ +++E
Sbjct: 2060 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE---- 2115
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
LKQ+ ++ + + ++ E +RR + E + ++ + + +
Sbjct: 2116 -----RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEME 2168
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
E L + ++++ + L+++ E+ + L+++++ + + + A R +
Sbjct: 2169 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2228
Query: 335 EQEQLNVEKRQIME-----ECENLKLECSK-------LQPSAVKQSDTMTEKERILAQSA 382
E + V+ ++ + E EN L LQ A K E R+ S
Sbjct: 2229 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL---SV 2285
Query: 383 SVEEVFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL------- 433
+ +E RL+Q + A+ + L + ++ +LK E+L+++K L
Sbjct: 2286 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2345
Query: 434 LSQEKEELQMSLLKLNNEYE-VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
L ++KE++ L + ++ +++ R + + +E RL L E Q+ +E++
Sbjct: 2346 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE--RLKLRVAEMSRAQARAEEDA 2403
Query: 493 L-----IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---DLNDEKKRVH 544
EI E + + AT+ + + L Q+ + D +L++ +L EK+++
Sbjct: 2404 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2463
Query: 545 QLEDDKMDITKE--LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSI 602
Q E + + E VQ+E+L+Q AL L+++ + E ++Q E
Sbjct: 2464 Q-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2522
Query: 603 QKENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+ + L+E ++ ++++ + R L+ S+ + ++ EAE +++ EL
Sbjct: 2523 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR--------RQHEAE-EGVRRKQEEL 2573
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
+QL + ++ + EN++L + + Q LA + +++ + +TL + +
Sbjct: 2574 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2633
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+ A+ + + + + + L A L+ LQ
Sbjct: 2634 DGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2670
Score = 83.2 bits (204), Expect = 2e-15
Identities = 194/1114 (17%), Positives = 417/1114 (37%), Gaps = 196/1114 (17%)
Query: 734 EEANKYEKTIEELSNARNLNTSALQLEHEHLIKL----------------NQKKDMEIAE 777
+E ++ ++ I EL + R L A + H ++L QK E+
Sbjct: 977 QEESRCQRCISELKDIR-LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1035
Query: 778 LKKNIEQMDTDHKET---------KDVLSSSLE-EQKQLTQLINKKEIFIEKLKERSSKL 827
L K + ++ + ++ L S LE +L Q+ + I++EKLK S +
Sbjct: 1036 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1095
Query: 828 ------QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
+E L + + L++ + + T+ E + + S+K +LR + P
Sbjct: 1096 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-----------KLRAQAEAQQP 1144
Query: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
D L E+ + E L++ +E + QLL+ Q + D
Sbjct: 1145 TFDA--------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1196
Query: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE-ERQDIQTDNSDIFQETKVQ 1000
+ + EQ+ + + E + + + + + + Q+ D Q + QE +
Sbjct: 1197 VRQRELEQLGR-QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1255
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
IE EK + + ++ + IK+ EL++ + L K +V ++
Sbjct: 1256 E-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1311
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
+ Q+ ++++ ++ +++ + +Q + ++ + L+ E E+ + ++
Sbjct: 1312 VIQEYVDLRTHYSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1370
Query: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
K + A A + + E K+L R + ++R ++ +DA
Sbjct: 1371 KQRQLAEAHAQAKAQAEREAKELQQRMQEE--------------VVRREEAAVDA----- 1411
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+QQ + ++E QQ+ Q A
Sbjct: 1412 ----------------------------------QQQKRSIQEELQQLR------QSSEA 1431
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
++Q + Q +A S+L+++ + + T+ + G E
Sbjct: 1432 EIQAKARQAEAA------ERSRLRIEEEIRVVRLQLEATERQRGGAE------------- 1472
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
G+L + + A Q+ E + +V ES Q E+E + E +
Sbjct: 1473 ------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1526
Query: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
A +E L + E E +E+++ ++ Q L+ + + +++K
Sbjct: 1527 AA----REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1582
Query: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
+ E + AV L+E + + ++ E R +E +
Sbjct: 1583 ASFAEKTAQLERSLQEEHV---AVAQLRE----------EAERRAQQQAEAERAREEAER 1629
Query: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
L+ +K + LR + ++K+LA + K+KE+ + + ++++++ +
Sbjct: 1630 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1689
Query: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Q+ Q LA Q + A + E+ RLR + + Q+ + L L + REA
Sbjct: 1690 AEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ----REAA 1744
Query: 1601 AA----EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
AA ++ EA+L K +E L S + A E + + + L+ + + +E A
Sbjct: 1745 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1804
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK--QKQLIAEWKKNAENLEG 1714
++++E +Q L+ +E+ A AE E+ ++L A + E
Sbjct: 1805 RLRALAEEAKRQRQLA------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1852
Query: 1715 KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
++ L E A + RL E + ++EE Q++ D++++L L +
Sbjct: 1853 EI-----ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA------DIEERLAQLRKA 1901
Query: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGS 1808
S+ ++++ + L + E+L L S
Sbjct: 1902 SDSELER--QKGLVEDTLRQRRQVEEEILALKAS 1933
Score = 70.1 bits (170), Expect = 2e-11
Identities = 268/1447 (18%), Positives = 557/1447 (38%), Gaps = 159/1447 (10%)
Query: 474 LNLEAKEQELNQSISEKET-LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
L++E + +L+ +I E+E L +E E L+ + TK + + +Q N+ D+++
Sbjct: 364 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTK-LQMEAGLCEEQLNQADALLQSD 422
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ L K + ++ ++LD + + +I+ + ND+ K + E + ++
Sbjct: 423 VRLLAAGK-----VPQRAGEVERDLD-KADSMIR--LLFNDVQTLKDGRHPQGEQMYRRV 474
Query: 593 NKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLK---- 645
+ E V+I+ E NL LK + +++++ + +Q + DS + LL
Sbjct: 475 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEE 534
Query: 646 --------EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
E ++ +++ L L++++++ ++ R +CL
Sbjct: 535 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL 594
Query: 698 AGNNQLSLEKNTIVETLKMEKGEIEAE---LCWAKKRLLEEANKYEKTIEELSNARNLNT 754
+L L+ ++ + K +E+ + A K L+ K E+ + + RN N
Sbjct: 595 G---RLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNM 651
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQM-DTDHKETKDVLSSSLEEQKQLTQLINKK 813
+A + + L++ + K+ +I EL+ +++ DH V S Q Q + ++
Sbjct: 652 TAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLC 711
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
LKE ++ Q D ++E LQ+ E LR
Sbjct: 712 CCIEAHLKENAAYFQFFSD-------------------------VREAEGQLQKLQEALR 746
Query: 874 EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE-------DQNQSK 926
+ S + D + + E QLN K HL K + +++ + +
Sbjct: 747 RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 806
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQM------------------NATHTQLFL------EKD 962
+ LL ++ E+ + Q+ A + FL E
Sbjct: 807 LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 866
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
E + L+ + + T H+ D+++ + VQ + + + L K E +R
Sbjct: 867 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTL-KPEEQRQA 925
Query: 1023 KGIKERELEIKLLNEKNISLTKQIDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHT 1081
E + L + ++ D+L ++ E G + QQ +Q+L S
Sbjct: 926 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRC 982
Query: 1082 QDVV--YLQQQLQAYAMEREKVFAVL----NEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Q + +LQ A E V + E RE + E K V + +
Sbjct: 983 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1042
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS----QKCQTLLAVLQTSS 1191
L E +K+ E S T+++ + K ++ +LS +K +T+ V++ +
Sbjct: 1043 LSAEAEKVLALPEPSPA---APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1099
Query: 1192 TGNEAGGVNSNQFEE------LLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
E + Q +E L E + K +KK+ + T ++ E QE
Sbjct: 1100 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1159
Query: 1246 LHQLQ-------AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
+LQ +V + ++L + ++ + + +L+ G++L + S L
Sbjct: 1160 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1219
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSA-ECLRASKSEVLSESSELLQQELEELRKSLQ 1357
L Q+ + L Q+ E LR + + L E E +++EE ++ +
Sbjct: 1220 ----GAWLQDARRRQEQIQAMPLADSQAVREQLR--QEQALLEEIERHGEKVEECQRFAK 1273
Query: 1358 EKDATIR--TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+ I+ LQ ++ A+ + K ++S I++ + + +L
Sbjct: 1274 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1333
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
IK S+ L E E L Q +ER+ +E + K + E +
Sbjct: 1334 IKFISETLRRMEE-------EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1386
Query: 1476 ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
E E + LQ+ + ++R +E + ++K + ++ L++ Q E+ ++
Sbjct: 1387 EREAKELQQRMQE--EVVRREEAAVDAQQQKR-SIQEELQQLRQSSEAEIQAKARQAEAA 1443
Query: 1536 QEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRNHL 1588
+ + ++E V L L+ + + + E+Q LR + + ++ +E ERLR +
Sbjct: 1444 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1503
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
+D R+ A + ++++ + EK + A+E QA + E Q V
Sbjct: 1504 ---QDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQAE-EAERRLRQAEVE 1558
Query: 1649 SKQRDETALQLS--VSQEQVKQYALSLANLQMVLEHFQQEEK---AMYSAELEKQKQLIA 1703
++ + AL+ + ++ +++ S A LE QEE A E E++ Q A
Sbjct: 1559 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1618
Query: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
E ++ E E ++ Q +EA A + +Q + + + E+ K + E
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 1764 VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHD 1823
+++ + +E +++K R L G E++RL + E+ QL +
Sbjct: 1679 AEEQAVRQRELAEQELEK--QRQLAEGTAQQRLAAEQELIRLRAET--EQGEQQRQLLEE 1734
Query: 1824 DQGGVTR 1830
+ + R
Sbjct: 1735 ELARLQR 1741
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 178 bits (452), Expect = 4e-44
Identities = 346/1697 (20%), Positives = 687/1697 (40%), Gaps = 229/1697 (13%)
Query: 170 SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS-------EICKLQNIIKELK 222
+Q E+ L V+RL +E + + S A T S+ ++ L I E
Sbjct: 997 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1056
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET 282
+ S I Q VL+ AH+++L E ++ L + E L+ L Q +
Sbjct: 1057 KTISLVIRGTQGAEEVLR-AHEEQLKE-AQAVPATLPELEATKASLKKLRAQAEAQQPTF 1114
Query: 283 DL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
D ++ Q+ + LQ E ++E+ +++ + ++ + D+ +RE EQL
Sbjct: 1115 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1174
Query: 341 VEKRQIMEECENL-----KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395
+ R E + L + Q A+ +D+ +E++ + A +EE+ R + +
Sbjct: 1175 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1234
Query: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455
+ + + + +D L K ++ +K + E + + L Y +
Sbjct: 1235 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1294
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILI 514
+ ++ I SE LR +E +E+ Q +E+ +AE+E L++Q Q A H
Sbjct: 1295 TTLTSQYIKFISET--LR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA--- 1348
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+K Q E ++ +L+Q + +E R + D Q+++ IQ E L
Sbjct: 1349 ---QAKAQAEREA--KELQQRMQEEVVRREEAAVDAQ--------QQKRSIQEE-----L 1390
Query: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD 634
+Q E +++ Q ++ S + I++E ++ + E + EL +
Sbjct: 1391 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1450
Query: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDVR 690
+ + +E +R Q+ S+ ++ E + K + E ++ + A E++R
Sbjct: 1451 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1510
Query: 691 HQLEECLAGNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
Q EE Q +E+ V+ L+ + EAEL + E+ + E++++E
Sbjct: 1511 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE--- 1567
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIA--ELKKNIE--QMDTDHKETKDVLSSSLEEQKQ 805
+ + QL E + Q+ + E A E ++ +E Q+ + + + + +QK
Sbjct: 1568 ---HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1624
Query: 806 LTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
L Q K++ E+ R K +E QA+R+ E+ Q +E++ + ++
Sbjct: 1625 LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLA 1678
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
++EL RLR E TE + QL LEEE+ Q+ Q
Sbjct: 1679 AEQELIRLRAE----------------TEQGEQQRQL------LEEELARLQREAAAATQ 1716
Query: 925 SKMQLLQSLQEQKKEMD-----EFRYQHEQMNATHTQL---------FLEKDEEIKSLQK 970
+ +L L + + EM+ + R + E + + F E EE L+
Sbjct: 1717 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1776
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
E+ K Q +D Q + + + E + + ++ +TE + +KE+E
Sbjct: 1777 LAEEAKRQRQLAEEDAAR------QRAEAERVLAEKLAAIGEATRLKTEAEI-ALKEKEA 1829
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
E +++ +L++DE Q++ LE QA H D+ Q
Sbjct: 1830 E-----------NERLRRLAEDEA------FQRRRLEEQA-------AQHKADIEERLAQ 1865
Query: 1091 LQ-AYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
L+ A E E+ ++ + R+ ++ E ++ + A+ E A + +L R S
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEE---ILALKASFEKAAAGKAELELELG-RIRS 1921
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+ +D R Q R++ + + ++ + V ++ + EA + Q + L+
Sbjct: 1922 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA----ARQRKAALE 1977
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTG 1269
E ++LK +V++ +++ QE QLQ L +LQ +
Sbjct: 1978 EVERLKAKVEEARRLRERAE-------------QESARQLQ---LAQEAAQKRLQAEEKA 2021
Query: 1270 LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD------IISPQLSSASLLT 1323
+ +Q E +L+ Q L Q Q + QL + + + + + ++ S
Sbjct: 2022 HAFAVQQKEQELQ---QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2078
Query: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
+ AE L+ S E ++ Q E+LRK +++ A R Q L AA +E+
Sbjct: 2079 VEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEM 2135
Query: 1384 ER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
E+ K EQT + Q++++ L+ L+E D ++L T + +
Sbjct: 2136 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2195
Query: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE------ 1495
+ + +++ ++ L +++ EN ++ R K+ + LQE K + E
Sbjct: 2196 EELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2253
Query: 1496 --------KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER- 1546
++ + ++ E++LKEK Q A Q+K + +Q R
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2313
Query: 1547 ---DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
D+ +A +Q E Q ++ R ++ + E ERL+ + E + R AE
Sbjct: 2314 LQEDKEQMA-QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR----AE 2368
Query: 1604 DREAKLRKKVTVLEEKL----------VSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
+ + RK+ + EKL V+ +E Q+ E L+E + + ++++
Sbjct: 2369 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2428
Query: 1654 ETA-----LQL------SVSQEQV-------KQYALSLANLQMVLEHFQQEEKA----MY 1691
+ LQL +V QEQ+ +Q LS + + E F ++EKA ++
Sbjct: 2429 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2488
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
E+ K +QL E ++ + +E + L ++EA A + + +Q+E+ +
Sbjct: 2489 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2548
Query: 1752 RQNELRQEMLDDVQKKL 1768
RQ E E+L + ++L
Sbjct: 2549 RQQE---ELLAEENQRL 2562
Score = 159 bits (402), Expect = 3e-38
Identities = 292/1451 (20%), Positives = 593/1451 (40%), Gaps = 171/1451 (11%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHE 83
A L S K + G+E V E D RT E L + + K ++ + E
Sbjct: 1259 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTTLTSQYIKFISETLRRME 1313
Query: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
E +QQ R +L EVE + K RQ+A K Q+ ++ +
Sbjct: 1314 EEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1371
Query: 144 SSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL----ESEVGHWRHIAQTSK 199
A + +QQ+ + E+ +L E+E+ A+ ++
Sbjct: 1372 REEA-------------------AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1412
Query: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
++ + +LQ E ++ ++ + A +++ E + R R ++
Sbjct: 1413 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1472
Query: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ---IEKVESTKKMEQLE-DKI 315
D +R + E L + ++ + E Q+ +Q L+ ++ E+ +++ Q E ++
Sbjct: 1473 DESQRKRQAEVEL----ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1528
Query: 316 KDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+ + L +A+ R + +L ++ E+ L+ LQ V + E E
Sbjct: 1529 RQVQVALETAQ------RSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAE 1579
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R Q A E +A +AE E+ R A + L+L+++ E + ++KSL
Sbjct: 1580 RRAQQQAEAE------RAREEAERELERWQLK------ANEALRLRLQAEEVAQQKSLAQ 1627
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISL-DSELHDLRLNLEAKEQELNQSISEKETLI 494
E E+ + + + A R L + EL R E Q+ + E L
Sbjct: 1628 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1687
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
AE E+ ++Q Q L++++L++ Q E + K +Q+L E +V
Sbjct: 1688 AETEQGEQQRQ-------LLEEELARLQREAAAATQK-RQELEAELAKVR---------- 1729
Query: 555 KELDVQKEKLIQSEV-ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
+ E L+ S+ A + T +K + ++E + + E ++ E K
Sbjct: 1730 ----AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1785
Query: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
+ EE+ +R R E + L + + + T LK EAE+ LK+ +E NE L+++A
Sbjct: 1786 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIA-LKEKEAE----NERLRRLAE 1839
Query: 674 DVKMENEKLVLACEDVRHQLEECL-----AGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
D + +L + +EE L A +++L +K + +TL+ ++ ++E E+ A
Sbjct: 1840 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEEEIL-A 1897
Query: 729 KKRLLEEANKYEKTIE-ELSNARNLNTSAL------QLEHEHLIKLNQKKDMEIAELKKN 781
K E+A + +E EL R+ L +LE +L +++ E ++
Sbjct: 1898 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1957
Query: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSK----LQEELDKYSQA 837
+++ +E ++LEE ++L + + E+ ++ S++ QE K QA
Sbjct: 1958 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2017
Query: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASE 897
K +++K++ L ++ + ++L E R A A+ + + E A
Sbjct: 2018 EEKAHAF--AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2075
Query: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Q+ EE + ++ E+Q Q++ Q + ++ +KE ++ + Q +
Sbjct: 2076 RRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2127
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDI--------QTDNSDIFQETKVQSLNIENGSE 1009
D E++ +K EQ Q + Q++ +TD+ + ++Q L E
Sbjct: 2128 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2187
Query: 1010 KHDLSKAETERLVKGIKERE---LEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQQ 1063
S+ E E ++ E L+ ++ E + + D + +E K+ Q+ ++
Sbjct: 2188 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2247
Query: 1064 -KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
L + A A +D+ QQ+ A M +EK+ AV +E + LK E +
Sbjct: 2248 AARLSVAAQEAARLRQLAEEDLA--QQRALAEKMLKEKMQAV-----QEATRLKAEAELL 2300
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKC 1180
KE A Q++ ++L E Q + ET Q R++ +E+ A +++
Sbjct: 2301 QQ---QKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2353
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+ +A + + E + ++ +++ +++ + E Q+ +T VQ ++ +
Sbjct: 2354 KLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2407
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Q + +L+ + KLQ + L ++S E + + QE +Q S
Sbjct: 2408 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS---FL 2464
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK----S 1355
+ KD LL + I + + L +K++ L E + QQ++E+ R+ S
Sbjct: 2465 SEKDSLLQRERFIEQEKAKLEQLFQD-----EVAKAQQLREEQQRQQQQMEQERQRLVAS 2519
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++E +E R + + + R++ E E ++L+E+ +LL+E+
Sbjct: 2520 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ----LQLLEEQHRA 2575
Query: 1416 IKAKSDQLLSS 1426
A S+++ +S
Sbjct: 2576 ALAHSEEVTAS 2586
Score = 128 bits (322), Expect = 5e-29
Identities = 319/1545 (20%), Positives = 631/1545 (40%), Gaps = 244/1545 (15%)
Query: 467 SELHDLRLNLEAKE----------------QELNQSISEKETLIAEIEELD----RQNQE 506
SEL D+RL LEA E +E Q I+E++ AE+E L R + E
Sbjct: 955 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1014
Query: 507 ATKHMILIKDQLSKQ--QNEGDSIISKLKQDLN------DEKKRVHQLEDDKMDITKELD 558
A K + L + + ++E + + KL+Q + ++ K + + + L
Sbjct: 1015 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1074
Query: 559 VQKEKLIQSE---VALNDLHLTKQKL----------EDKVENLVDQLNKSQESNVSIQKE 605
+E+L +++ L +L TK L + + L D+L +QE +Q+
Sbjct: 1075 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1134
Query: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQN-------L 658
+ E + + E ++++ L Q ++ + L++ ++R +++ L
Sbjct: 1135 HGERDVEVERWRERVAQLLERWQAVLAQ---TDVRQRELEQLGRQLRYYRESADPLGAWL 1191
Query: 659 SELEQLNENLKKVAF-DVKMENEKL----VLACEDVRH--QLEECLAGNNQLSLEKNTIV 711
+ + E ++ + D + E+L L E RH ++EEC Q
Sbjct: 1192 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1251
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
L K ++E AKK ++ + E I+E + R + L ++ IK +
Sbjct: 1252 LQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQY-IKFISET 1308
Query: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK-LKERSSKLQEE 830
+ E ++ EQ + +E + ++LE+Q+QL + + + E+ KE ++QEE
Sbjct: 1309 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1368
Query: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ----EELERLR---EEQSRTAPVA 883
+ + +A + +++I+E+ + L E + E ER R EE+ R +
Sbjct: 1369 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1428
Query: 884 DPKT-------LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL--- 933
T + L + + K +EE + ++ ++D++Q K Q L
Sbjct: 1429 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488
Query: 934 -----------QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK-SLQKTIEQIKTQLHE 981
Q + ++E R Q E+ Q +E+ +++ +L+ + +L
Sbjct: 1489 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1548
Query: 982 ERQDIQTDNSDI---FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELE------- 1031
+R + + QE V + +E+ +AE ER + ERELE
Sbjct: 1549 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER-AREEAERELERWQLKAN 1607
Query: 1032 --IKL-LNEKNISLTKQIDQL----SKDEV-------GKL-TQIIQQKDLEIQALHARIS 1076
++L L + ++ K + Q K+E GK Q ++Q++L Q L +
Sbjct: 1608 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1667
Query: 1077 STSHT--------QDVVYL-------QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 1121
T Q+++ L +QQ Q E ++ T++ L+ E K
Sbjct: 1668 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1727
Query: 1122 ----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI-------IREKD 1170
M ++A+K A + + ++K R E+ FRE + +R+ R++
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAEEAARLRALAEEAKRQRQ 1786
Query: 1171 I-EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM--EEWKQQ 1227
+ E DA Q+ + + + + EA + + + E L+E++ ++++++ +E Q+
Sbjct: 1787 LAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDEAFQR 1845
Query: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Q QH+ A ++E L QL+ + + L D + E+ LK ++
Sbjct: 1846 RRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1904
Query: 1288 L----AQVQHSIGQL-CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
A+++ +G++ N +D L K +L +A + E R ++E + S
Sbjct: 1905 AAAGKAELELELGRIRSNAEDTLRSK---EQAELEAARQRQLAAEEERRRREAEERVQKS 1961
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS---------------ELERKE 1387
++E RK+ E+ ++ E RL + S + E K
Sbjct: 1962 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2021
Query: 1388 H----EQTDSEIKQ-LKEKQDVLQKLLKEKDLLIKAKSD------QLLSSNENFTNKVNE 1436
H +Q + E++Q L+++Q VL +L E + +A + Q +V E
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2081
Query: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
E L+Q+ + + KL+ E E+ E R + E AL++ + M + K
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHK 2139
Query: 1497 EFECHSMKEKALAFEQL--LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV--MLA 1552
+F ++++KA ++L L+ + + + N L ++ ++ + ++R QV L
Sbjct: 2140 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2199
Query: 1553 LKQKQMENTA-------LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED- 1604
+ QME + +N LRDK+ + + L+ + + + R ++AA++
Sbjct: 2200 SVRVQMEELSKLKARIEAENRALILRDKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2258
Query: 1605 ------REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
E L ++ + E+ L A++ A+ + + E LQ+Q + +Q A +
Sbjct: 2259 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQEQ----ARR 2313
Query: 1659 LSVSQEQV-KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW-------KKNAE 1710
L +EQ+ +Q A Q LE +Q + M SAE E+ K +AE +++A+
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQ 2372
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ-----------IEELKRQNE---- 1755
+ + E L A L + L+++ +Q I EL+R+ E
Sbjct: 2373 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2432
Query: 1756 ------LRQEMLDDVQKKLM-----SLANSSEGKVDKVLMRNLFI 1789
L+ E + VQ++ + +L S + D +L R FI
Sbjct: 2433 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2477
Score = 119 bits (298), Expect = 3e-26
Identities = 237/1253 (18%), Positives = 497/1253 (39%), Gaps = 200/1253 (15%)
Query: 586 ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
+ L+ L + + Q+ ELK+ Q E +R + L L+++ + +
Sbjct: 934 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 993
Query: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL------ACEDVRHQLEECLAG 699
+++A+ +E+E L + + +++ E EK++ A +R +LE L
Sbjct: 994 QQKAQ--------AEVEGLGKGVARLS----AEAEKVLALPEPSPAAPTLRSELELTLGK 1041
Query: 700 NNQLSLEKNTIVETLKMEKGEIEA-----ELCWAKKRLLEEANKYEKTIEELSNARNLNT 754
Q+ +E LK I E+ A + L+EA T+ EL +
Sbjct: 1042 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK---- 1097
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ +L+ E +D L + E ++L Q +++
Sbjct: 1098 ------------------ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1139
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE--RL 872
+ +E+ +ER ++L L+++ L + ++ ++ +E+ R L +E + L L+ R
Sbjct: 1140 VEVERWRERVAQL---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1196
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
R+EQ + P+AD + + QL + LEE +H +K+ E Q +K Q + +
Sbjct: 1197 RQEQIQAMPLADSQAVRE---------QLRQEQALLEEIERHGEKVEECQRFAK-QYINA 1246
Query: 933 LQEQKKEMDEFRYQHE-----------------------QMNATHTQLFLEKDEEIKSLQ 969
+++ + ++ ++ Q E + +++L + IK +
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1306
Query: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
+T+ +++ + Q + + + E + +E H +KA+ ER K +++R
Sbjct: 1307 ETLRRMEEEERLAEQQ-RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1365
Query: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
E +++ + ++ Q + S E +L Q+ Q + EIQA + + ++ + +++
Sbjct: 1366 QE-EVVRREEAAVDAQQQKRSIQE--ELQQLRQSSEAEIQAKARQAEAAERSR--LRIEE 1420
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+++ ++ E R+ + E + EA + Q+E ++L + +
Sbjct: 1421 EIRVVRLQLEAT-------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1473
Query: 1150 SGQDMFRETIQNLSRI------IREKDIEIDALSQ------------------KCQTLLA 1185
Q + ++ SR+ REK + AL + + + +
Sbjct: 1474 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1533
Query: 1186 VLQTSSTGNEAG--------GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
L+T+ EA + Q E LQE Q+++ E + Q + +
Sbjct: 1534 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1593
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
E A+ + E QL+A + +LQ + +S Q E + ++ + + +
Sbjct: 1594 E-AERELERWQLKANEAL----RLRLQAEEVAQQKSLAQAEAE-----KQKEEAEREARR 1643
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
++ + + ++ +L L +A+ A+ +QEL LR +
Sbjct: 1644 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA------------EQELIRLRAETE 1691
Query: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL---QKLLKEKDL 1414
+ + + L+E RL AA ++ + ++ ++E+ +++ + +VL + +E+
Sbjct: 1692 QGEQQRQLLEEELARLQREAAAATQ----KRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Query: 1415 LIKAKSDQLLSSNEN-FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIV---- 1469
KS Q L + F E LR K + + E D + + E E+++
Sbjct: 1748 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1807
Query: 1470 ----ETYRGKETEYQALQET---NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
E R K AL+E N + + ++ F+ ++E+A + ++E+
Sbjct: 1808 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1867
Query: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
+ L K + E T+ +++ ++ +LALK + A + E++ L RSN E
Sbjct: 1868 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE-LELGRIRSNAEDT 1926
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
E E + R+ A E+R + EE++ S A E A+ Q +E ++
Sbjct: 1927 LRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQRKAALEEVE 1980
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
+ +K + L+ QE +Q L A+ QK+L
Sbjct: 1981 R---LKAKVEEARRLRERAEQESARQLQL---------------------AQEAAQKRLQ 2016
Query: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNE 1755
AE K +A ++ K LQ+ L + + LD E E+ EE + Q E
Sbjct: 2017 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2069
Score = 92.8 bits (229), Expect = 3e-18
Identities = 131/757 (17%), Positives = 311/757 (41%), Gaps = 65/757 (8%)
Query: 41 GTEEVEAELPDSRTKEIEAIHAILRSENE--RLKKLCTDLEEKHEASEIQIKQQSTSYRN 98
G E+E EL R+ + + + ++E E R ++L + E + +E ++++ +
Sbjct: 1908 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1967
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+Q++ + ++ + +++ + A Q + A H A
Sbjct: 1968 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2027
Query: 159 DDDMDFGDIISSQQEI-NRLSNEVS---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+ + + +Q + ++L E R E R A+ AQ +++E
Sbjct: 2028 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE---- 2083
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
LKQ+ ++ + + ++ E +RR + E + ++ + + +
Sbjct: 2084 -----RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEME 2136
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
E L + ++++ + L+++ E+ + L+++++ + + + A R +
Sbjct: 2137 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2196
Query: 335 EQEQLNVEKRQIME-----ECENLKLECSK-------LQPSAVKQSDTMTEKERILAQSA 382
E + V+ ++ + E EN L LQ A K E R+ S
Sbjct: 2197 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL---SV 2253
Query: 383 SVEEVFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL------- 433
+ +E RL+Q + A+ + L + ++ +LK E+L+++K L
Sbjct: 2254 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2313
Query: 434 LSQEKEELQMSLLKLNNEYE-VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
L ++KE++ L + ++ +++ R + + +E RL L E Q+ +E++
Sbjct: 2314 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE--RLKLRVAEMSRAQARAEEDA 2371
Query: 493 L-----IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---DLNDEKKRVH 544
EI E + + AT+ + + L Q+ + D +L++ +L EK+++
Sbjct: 2372 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2431
Query: 545 QLEDDKMDITKE--LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSI 602
Q E + + E VQ+E+L+Q AL L+++ + E ++Q E
Sbjct: 2432 Q-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2490
Query: 603 QKENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+ + L+E ++ ++++ + R L+ S+ + ++ EAE +++ EL
Sbjct: 2491 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR--------RQHEAE-EGVRRKQEEL 2541
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
+QL + ++ + EN++L + + Q LA + +++ + +TL + +
Sbjct: 2542 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2601
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+ A+ + + + + + L A L+ LQ
Sbjct: 2602 DGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2638
Score = 83.2 bits (204), Expect = 2e-15
Identities = 194/1114 (17%), Positives = 417/1114 (37%), Gaps = 196/1114 (17%)
Query: 734 EEANKYEKTIEELSNARNLNTSALQLEHEHLIKL----------------NQKKDMEIAE 777
+E ++ ++ I EL + R L A + H ++L QK E+
Sbjct: 945 QEESRCQRCISELKDIR-LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1003
Query: 778 LKKNIEQMDTDHKET---------KDVLSSSLE-EQKQLTQLINKKEIFIEKLKERSSKL 827
L K + ++ + ++ L S LE +L Q+ + I++EKLK S +
Sbjct: 1004 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1063
Query: 828 ------QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
+E L + + L++ + + T+ E + + S+K +LR + P
Sbjct: 1064 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-----------KLRAQAEAQQP 1112
Query: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
D L E+ + E L++ +E + QLL+ Q + D
Sbjct: 1113 TFDA--------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1164
Query: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE-ERQDIQTDNSDIFQETKVQ 1000
+ + EQ+ + + E + + + + + + Q+ D Q + QE +
Sbjct: 1165 VRQRELEQLGR-QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1223
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
IE EK + + ++ + IK+ EL++ + L K +V ++
Sbjct: 1224 E-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1279
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
+ Q+ ++++ ++ +++ + +Q + ++ + L+ E E+ + ++
Sbjct: 1280 VIQEYVDLRTHYSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1338
Query: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
K + A A + + E K+L R + ++R ++ +DA
Sbjct: 1339 KQRQLAEAHAQAKAQAEREAKELQQRMQEE--------------VVRREEAAVDA----- 1379
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+QQ + ++E QQ+ Q A
Sbjct: 1380 ----------------------------------QQQKRSIQEELQQLR------QSSEA 1399
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
++Q + Q +A S+L+++ + + T+ + G E
Sbjct: 1400 EIQAKARQAEAA------ERSRLRIEEEIRVVRLQLEATERQRGGAE------------- 1440
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
G+L + + A Q+ E + +V ES Q E+E + E +
Sbjct: 1441 ------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1494
Query: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
A +E L + E E +E+++ ++ Q L+ + + +++K
Sbjct: 1495 AA----REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1550
Query: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
+ E + AV L+E + + ++ E R +E +
Sbjct: 1551 ASFAEKTAQLERSLQEEHV---AVAQLRE----------EAERRAQQQAEAERAREEAER 1597
Query: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
L+ +K + LR + ++K+LA + K+KE+ + + ++++++ +
Sbjct: 1598 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1657
Query: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Q+ Q LA Q + A + E+ RLR + + Q+ + L L + REA
Sbjct: 1658 AEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ----REAA 1712
Query: 1601 AA----EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
AA ++ EA+L K +E L S + A E + + + L+ + + +E A
Sbjct: 1713 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1772
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK--QKQLIAEWKKNAENLEG 1714
++++E +Q L+ +E+ A AE E+ ++L A + E
Sbjct: 1773 RLRALAEEAKRQRQLA------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1820
Query: 1715 KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
++ L E A + RL E + ++EE Q++ D++++L L +
Sbjct: 1821 EI-----ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA------DIEERLAQLRKA 1869
Query: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGS 1808
S+ ++++ + L + E+L L S
Sbjct: 1870 SDSELER--QKGLVEDTLRQRRQVEEEILALKAS 1901
Score = 70.1 bits (170), Expect = 2e-11
Identities = 268/1447 (18%), Positives = 557/1447 (38%), Gaps = 159/1447 (10%)
Query: 474 LNLEAKEQELNQSISEKET-LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
L++E + +L+ +I E+E L +E E L+ + TK + + +Q N+ D+++
Sbjct: 332 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTK-LQMEAGLCEEQLNQADALLQSD 390
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ L K + ++ ++LD + + +I+ + ND+ K + E + ++
Sbjct: 391 VRLLAAGK-----VPQRAGEVERDLD-KADSMIR--LLFNDVQTLKDGRHPQGEQMYRRV 442
Query: 593 NKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLK---- 645
+ E V+I+ E NL LK + +++++ + +Q + DS + LL
Sbjct: 443 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEE 502
Query: 646 --------EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
E ++ +++ L L++++++ ++ R +CL
Sbjct: 503 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL 562
Query: 698 AGNNQLSLEKNTIVETLKMEKGEIEAE---LCWAKKRLLEEANKYEKTIEELSNARNLNT 754
+L L+ ++ + K +E+ + A K L+ K E+ + + RN N
Sbjct: 563 G---RLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNM 619
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQM-DTDHKETKDVLSSSLEEQKQLTQLINKK 813
+A + + L++ + K+ +I EL+ +++ DH V S Q Q + ++
Sbjct: 620 TAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLC 679
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
LKE ++ Q D ++E LQ+ E LR
Sbjct: 680 CCIEAHLKENAAYFQFFSD-------------------------VREAEGQLQKLQEALR 714
Query: 874 EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE-------DQNQSK 926
+ S + D + + E QLN K HL K + +++ + +
Sbjct: 715 RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 774
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQM------------------NATHTQLFL------EKD 962
+ LL ++ E+ + Q+ A + FL E
Sbjct: 775 LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 834
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
E + L+ + + T H+ D+++ + VQ + + + L K E +R
Sbjct: 835 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTL-KPEEQRQA 893
Query: 1023 KGIKERELEIKLLNEKNISLTKQIDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHT 1081
E + L + ++ D+L ++ E G + QQ +Q+L S
Sbjct: 894 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRC 950
Query: 1082 QDVV--YLQQQLQAYAMEREKVFAVL----NEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Q + +LQ A E V + E RE + E K V + +
Sbjct: 951 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1010
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS----QKCQTLLAVLQTSS 1191
L E +K+ E S T+++ + K ++ +LS +K +T+ V++ +
Sbjct: 1011 LSAEAEKVLALPEPSPA---APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1067
Query: 1192 TGNEAGGVNSNQFEE------LLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
E + Q +E L E + K +KK+ + T ++ E QE
Sbjct: 1068 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1127
Query: 1246 LHQLQ-------AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
+LQ +V + ++L + ++ + + +L+ G++L + S L
Sbjct: 1128 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1187
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSA-ECLRASKSEVLSESSELLQQELEELRKSLQ 1357
L Q+ + L Q+ E LR + + L E E +++EE ++ +
Sbjct: 1188 ----GAWLQDARRRQEQIQAMPLADSQAVREQLR--QEQALLEEIERHGEKVEECQRFAK 1241
Query: 1358 EKDATIR--TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+ I+ LQ ++ A+ + K ++S I++ + + +L
Sbjct: 1242 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1301
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
IK S+ L E E L Q +ER+ +E + K + E +
Sbjct: 1302 IKFISETLRRMEE-------EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1354
Query: 1476 ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
E E + LQ+ + ++R +E + ++K + ++ L++ Q E+ ++
Sbjct: 1355 EREAKELQQRMQE--EVVRREEAAVDAQQQKR-SIQEELQQLRQSSEAEIQAKARQAEAA 1411
Query: 1536 QEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRNHL 1588
+ + ++E V L L+ + + + E+Q LR + + ++ +E ERLR +
Sbjct: 1412 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1471
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
+D R+ A + ++++ + EK + A+E QA + E Q V
Sbjct: 1472 ---QDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQAE-EAERRLRQAEVE 1526
Query: 1649 SKQRDETALQLS--VSQEQVKQYALSLANLQMVLEHFQQEEK---AMYSAELEKQKQLIA 1703
++ + AL+ + ++ +++ S A LE QEE A E E++ Q A
Sbjct: 1527 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1586
Query: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
E ++ E E ++ Q +EA A + +Q + + + E+ K + E
Sbjct: 1587 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1646
Query: 1764 VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHD 1823
+++ + +E +++K R L G E++RL + E+ QL +
Sbjct: 1647 AEEQAVRQRELAEQELEK--QRQLAEGTAQQRLAAEQELIRLRAET--EQGEQQRQLLEE 1702
Query: 1824 DQGGVTR 1830
+ + R
Sbjct: 1703 ELARLQR 1709
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 178 bits (452), Expect = 4e-44
Identities = 346/1697 (20%), Positives = 687/1697 (40%), Gaps = 229/1697 (13%)
Query: 170 SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS-------EICKLQNIIKELK 222
+Q E+ L V+RL +E + + S A T S+ ++ L I E
Sbjct: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1225
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET 282
+ S I Q VL+ AH+++L E ++ L + E L+ L Q +
Sbjct: 1226 KTISLVIRGTQGAEEVLR-AHEEQLKE-AQAVPATLPELEATKASLKKLRAQAEAQQPTF 1283
Query: 283 DL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
D ++ Q+ + LQ E ++E+ +++ + ++ + D+ +RE EQL
Sbjct: 1284 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1343
Query: 341 VEKRQIMEECENL-----KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395
+ R E + L + Q A+ +D+ +E++ + A +EE+ R + +
Sbjct: 1344 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1403
Query: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455
+ + + + +D L K ++ +K + E + + L Y +
Sbjct: 1404 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1463
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILI 514
+ ++ I SE LR +E +E+ Q +E+ +AE+E L++Q Q A H
Sbjct: 1464 TTLTSQYIKFISET--LR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA--- 1517
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+K Q E ++ +L+Q + +E R + D Q+++ IQ E L
Sbjct: 1518 ---QAKAQAEREA--KELQQRMQEEVVRREEAAVDAQ--------QQKRSIQEE-----L 1559
Query: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD 634
+Q E +++ Q ++ S + I++E ++ + E + EL +
Sbjct: 1560 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1619
Query: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDVR 690
+ + +E +R Q+ S+ ++ E + K + E ++ + A E++R
Sbjct: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679
Query: 691 HQLEECLAGNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
Q EE Q +E+ V+ L+ + EAEL + E+ + E++++E
Sbjct: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE--- 1736
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIA--ELKKNIE--QMDTDHKETKDVLSSSLEEQKQ 805
+ + QL E + Q+ + E A E ++ +E Q+ + + + + +QK
Sbjct: 1737 ---HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1793
Query: 806 LTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
L Q K++ E+ R K +E QA+R+ E+ Q +E++ + ++
Sbjct: 1794 LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLA 1847
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
++EL RLR E TE + QL LEEE+ Q+ Q
Sbjct: 1848 AEQELIRLRAE----------------TEQGEQQRQL------LEEELARLQREAAAATQ 1885
Query: 925 SKMQLLQSLQEQKKEMD-----EFRYQHEQMNATHTQL---------FLEKDEEIKSLQK 970
+ +L L + + EM+ + R + E + + F E EE L+
Sbjct: 1886 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1945
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
E+ K Q +D Q + + + E + + ++ +TE + +KE+E
Sbjct: 1946 LAEEAKRQRQLAEEDAAR------QRAEAERVLAEKLAAIGEATRLKTEAEI-ALKEKEA 1998
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
E +++ +L++DE Q++ LE QA H D+ Q
Sbjct: 1999 E-----------NERLRRLAEDEA------FQRRRLEEQA-------AQHKADIEERLAQ 2034
Query: 1091 LQ-AYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
L+ A E E+ ++ + R+ ++ E ++ + A+ E A + +L R S
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEE---ILALKASFEKAAAGKAELELELG-RIRS 2090
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+ +D R Q R++ + + ++ + V ++ + EA + Q + L+
Sbjct: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA----ARQRKAALE 2146
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTG 1269
E ++LK +V++ +++ QE QLQ L +LQ +
Sbjct: 2147 EVERLKAKVEEARRLRERAE-------------QESARQLQ---LAQEAAQKRLQAEEKA 2190
Query: 1270 LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD------IISPQLSSASLLT 1323
+ +Q E +L+ Q L Q Q + QL + + + + + ++ S
Sbjct: 2191 HAFAVQQKEQELQ---QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247
Query: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
+ AE L+ S E ++ Q E+LRK +++ A R Q L AA +E+
Sbjct: 2248 VEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEM 2304
Query: 1384 ER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
E+ K EQT + Q++++ L+ L+E D ++L T + +
Sbjct: 2305 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2364
Query: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE------ 1495
+ + +++ ++ L +++ EN ++ R K+ + LQE K + E
Sbjct: 2365 EELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2422
Query: 1496 --------KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER- 1546
++ + ++ E++LKEK Q A Q+K + +Q R
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2482
Query: 1547 ---DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
D+ +A +Q E Q ++ R ++ + E ERL+ + E + R AE
Sbjct: 2483 LQEDKEQMA-QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR----AE 2537
Query: 1604 DREAKLRKKVTVLEEKL----------VSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
+ + RK+ + EKL V+ +E Q+ E L+E + + ++++
Sbjct: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597
Query: 1654 ETA-----LQL------SVSQEQV-------KQYALSLANLQMVLEHFQQEEKA----MY 1691
+ LQL +V QEQ+ +Q LS + + E F ++EKA ++
Sbjct: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
E+ K +QL E ++ + +E + L ++EA A + + +Q+E+ +
Sbjct: 2658 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2717
Query: 1752 RQNELRQEMLDDVQKKL 1768
RQ E E+L + ++L
Sbjct: 2718 RQQE---ELLAEENQRL 2731
Score = 159 bits (402), Expect = 3e-38
Identities = 292/1451 (20%), Positives = 593/1451 (40%), Gaps = 171/1451 (11%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHE 83
A L S K + G+E V E D RT E L + + K ++ + E
Sbjct: 1428 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTTLTSQYIKFISETLRRME 1482
Query: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
E +QQ R +L EVE + K RQ+A K Q+ ++ +
Sbjct: 1483 EEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540
Query: 144 SSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL----ESEVGHWRHIAQTSK 199
A + +QQ+ + E+ +L E+E+ A+ ++
Sbjct: 1541 REEA-------------------AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1581
Query: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
++ + +LQ E ++ ++ + A +++ E + R R ++
Sbjct: 1582 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1641
Query: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ---IEKVESTKKMEQLE-DKI 315
D +R + E L + ++ + E Q+ +Q L+ ++ E+ +++ Q E ++
Sbjct: 1642 DESQRKRQAEVEL----ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1697
Query: 316 KDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+ + L +A+ R + +L ++ E+ L+ LQ V + E E
Sbjct: 1698 RQVQVALETAQ------RSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAE 1748
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R Q A E +A +AE E+ R A + L+L+++ E + ++KSL
Sbjct: 1749 RRAQQQAEAE------RAREEAERELERWQLK------ANEALRLRLQAEEVAQQKSLAQ 1796
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISL-DSELHDLRLNLEAKEQELNQSISEKETLI 494
E E+ + + + A R L + EL R E Q+ + E L
Sbjct: 1797 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1856
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
AE E+ ++Q Q L++++L++ Q E + K +Q+L E +V
Sbjct: 1857 AETEQGEQQRQ-------LLEEELARLQREAAAATQK-RQELEAELAKVR---------- 1898
Query: 555 KELDVQKEKLIQSEV-ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
+ E L+ S+ A + T +K + ++E + + E ++ E K
Sbjct: 1899 ----AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954
Query: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
+ EE+ +R R E + L + + + T LK EAE+ LK+ +E NE L+++A
Sbjct: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIA-LKEKEAE----NERLRRLAE 2008
Query: 674 DVKMENEKLVLACEDVRHQLEECL-----AGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
D + +L + +EE L A +++L +K + +TL+ ++ ++E E+ A
Sbjct: 2009 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEEEIL-A 2066
Query: 729 KKRLLEEANKYEKTIE-ELSNARNLNTSAL------QLEHEHLIKLNQKKDMEIAELKKN 781
K E+A + +E EL R+ L +LE +L +++ E ++
Sbjct: 2067 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126
Query: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSK----LQEELDKYSQA 837
+++ +E ++LEE ++L + + E+ ++ S++ QE K QA
Sbjct: 2127 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2186
Query: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASE 897
K +++K++ L ++ + ++L E R A A+ + + E A
Sbjct: 2187 EEKAHAF--AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244
Query: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Q+ EE + ++ E+Q Q++ Q + ++ +KE ++ + Q +
Sbjct: 2245 RRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2296
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDI--------QTDNSDIFQETKVQSLNIENGSE 1009
D E++ +K EQ Q + Q++ +TD+ + ++Q L E
Sbjct: 2297 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2356
Query: 1010 KHDLSKAETERLVKGIKERE---LEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQQ 1063
S+ E E ++ E L+ ++ E + + D + +E K+ Q+ ++
Sbjct: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2416
Query: 1064 -KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
L + A A +D+ QQ+ A M +EK+ AV +E + LK E +
Sbjct: 2417 AARLSVAAQEAARLRQLAEEDLA--QQRALAEKMLKEKMQAV-----QEATRLKAEAELL 2469
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKC 1180
KE A Q++ ++L E Q + ET Q R++ +E+ A +++
Sbjct: 2470 QQ---QKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2522
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+ +A + + E + ++ +++ +++ + E Q+ +T VQ ++ +
Sbjct: 2523 KLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2576
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Q + +L+ + KLQ + L ++S E + + QE +Q S
Sbjct: 2577 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS---FL 2633
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK----S 1355
+ KD LL + I + + L +K++ L E + QQ++E+ R+ S
Sbjct: 2634 SEKDSLLQRERFIEQEKAKLEQLFQD-----EVAKAQQLREEQQRQQQQMEQERQRLVAS 2688
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++E +E R + + + R++ E E ++L+E+ +LL+E+
Sbjct: 2689 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ----LQLLEEQHRA 2744
Query: 1416 IKAKSDQLLSS 1426
A S+++ +S
Sbjct: 2745 ALAHSEEVTAS 2755
Score = 128 bits (322), Expect = 5e-29
Identities = 319/1545 (20%), Positives = 631/1545 (40%), Gaps = 244/1545 (15%)
Query: 467 SELHDLRLNLEAKE----------------QELNQSISEKETLIAEIEELD----RQNQE 506
SEL D+RL LEA E +E Q I+E++ AE+E L R + E
Sbjct: 1124 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1183
Query: 507 ATKHMILIKDQLSKQ--QNEGDSIISKLKQDLN------DEKKRVHQLEDDKMDITKELD 558
A K + L + + ++E + + KL+Q + ++ K + + + L
Sbjct: 1184 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1243
Query: 559 VQKEKLIQSE---VALNDLHLTKQKL----------EDKVENLVDQLNKSQESNVSIQKE 605
+E+L +++ L +L TK L + + L D+L +QE +Q+
Sbjct: 1244 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1303
Query: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQN-------L 658
+ E + + E ++++ L Q ++ + L++ ++R +++ L
Sbjct: 1304 HGERDVEVERWRERVAQLLERWQAVLAQ---TDVRQRELEQLGRQLRYYRESADPLGAWL 1360
Query: 659 SELEQLNENLKKVAF-DVKMENEKL----VLACEDVRH--QLEECLAGNNQLSLEKNTIV 711
+ + E ++ + D + E+L L E RH ++EEC Q
Sbjct: 1361 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1420
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
L K ++E AKK ++ + E I+E + R + L ++ IK +
Sbjct: 1421 LQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQY-IKFISET 1477
Query: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK-LKERSSKLQEE 830
+ E ++ EQ + +E + ++LE+Q+QL + + + E+ KE ++QEE
Sbjct: 1478 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1537
Query: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ----EELERLR---EEQSRTAPVA 883
+ + +A + +++I+E+ + L E + E ER R EE+ R +
Sbjct: 1538 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1597
Query: 884 DPKT-------LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL--- 933
T + L + + K +EE + ++ ++D++Q K Q L
Sbjct: 1598 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657
Query: 934 -----------QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK-SLQKTIEQIKTQLHE 981
Q + ++E R Q E+ Q +E+ +++ +L+ + +L
Sbjct: 1658 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717
Query: 982 ERQDIQTDNSDI---FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELE------- 1031
+R + + QE V + +E+ +AE ER + ERELE
Sbjct: 1718 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER-AREEAERELERWQLKAN 1776
Query: 1032 --IKL-LNEKNISLTKQIDQL----SKDEV-------GKL-TQIIQQKDLEIQALHARIS 1076
++L L + ++ K + Q K+E GK Q ++Q++L Q L +
Sbjct: 1777 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836
Query: 1077 STSHT--------QDVVYL-------QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 1121
T Q+++ L +QQ Q E ++ T++ L+ E K
Sbjct: 1837 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1896
Query: 1122 ----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI-------IREKD 1170
M ++A+K A + + ++K R E+ FRE + +R+ R++
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAEEAARLRALAEEAKRQRQ 1955
Query: 1171 I-EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM--EEWKQQ 1227
+ E DA Q+ + + + + EA + + + E L+E++ ++++++ +E Q+
Sbjct: 1956 LAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDEAFQR 2014
Query: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Q QH+ A ++E L QL+ + + L D + E+ LK ++
Sbjct: 2015 RRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 2073
Query: 1288 L----AQVQHSIGQL-CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
A+++ +G++ N +D L K +L +A + E R ++E + S
Sbjct: 2074 AAAGKAELELELGRIRSNAEDTLRSK---EQAELEAARQRQLAAEEERRRREAEERVQKS 2130
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS---------------ELERKE 1387
++E RK+ E+ ++ E RL + S + E K
Sbjct: 2131 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2190
Query: 1388 H----EQTDSEIKQ-LKEKQDVLQKLLKEKDLLIKAKSD------QLLSSNENFTNKVNE 1436
H +Q + E++Q L+++Q VL +L E + +A + Q +V E
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2250
Query: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
E L+Q+ + + KL+ E E+ E R + E AL++ + M + K
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHK 2308
Query: 1497 EFECHSMKEKALAFEQL--LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV--MLA 1552
+F ++++KA ++L L+ + + + N L ++ ++ + ++R QV L
Sbjct: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2368
Query: 1553 LKQKQMENTA-------LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED- 1604
+ QME + +N LRDK+ + + L+ + + + R ++AA++
Sbjct: 2369 SVRVQMEELSKLKARIEAENRALILRDKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427
Query: 1605 ------REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
E L ++ + E+ L A++ A+ + + E LQ+Q + +Q A +
Sbjct: 2428 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQEQ----ARR 2482
Query: 1659 LSVSQEQV-KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW-------KKNAE 1710
L +EQ+ +Q A Q LE +Q + M SAE E+ K +AE +++A+
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQ 2541
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ-----------IEELKRQNE---- 1755
+ + E L A L + L+++ +Q I EL+R+ E
Sbjct: 2542 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601
Query: 1756 ------LRQEMLDDVQKKLM-----SLANSSEGKVDKVLMRNLFI 1789
L+ E + VQ++ + +L S + D +L R FI
Sbjct: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2646
Score = 119 bits (298), Expect = 3e-26
Identities = 237/1253 (18%), Positives = 497/1253 (39%), Gaps = 200/1253 (15%)
Query: 586 ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
+ L+ L + + Q+ ELK+ Q E +R + L L+++ + +
Sbjct: 1103 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1162
Query: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL------ACEDVRHQLEECLAG 699
+++A+ +E+E L + + +++ E EK++ A +R +LE L
Sbjct: 1163 QQKAQ--------AEVEGLGKGVARLS----AEAEKVLALPEPSPAAPTLRSELELTLGK 1210
Query: 700 NNQLSLEKNTIVETLKMEKGEIEA-----ELCWAKKRLLEEANKYEKTIEELSNARNLNT 754
Q+ +E LK I E+ A + L+EA T+ EL +
Sbjct: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK---- 1266
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ +L+ E +D L + E ++L Q +++
Sbjct: 1267 ------------------ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE--RL 872
+ +E+ +ER ++L L+++ L + ++ ++ +E+ R L +E + L L+ R
Sbjct: 1309 VEVERWRERVAQL---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1365
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
R+EQ + P+AD + + QL + LEE +H +K+ E Q +K Q + +
Sbjct: 1366 RQEQIQAMPLADSQAVRE---------QLRQEQALLEEIERHGEKVEECQRFAK-QYINA 1415
Query: 933 LQEQKKEMDEFRYQHE-----------------------QMNATHTQLFLEKDEEIKSLQ 969
+++ + ++ ++ Q E + +++L + IK +
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1475
Query: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
+T+ +++ + Q + + + E + +E H +KA+ ER K +++R
Sbjct: 1476 ETLRRMEEEERLAEQQ-RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1534
Query: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
E +++ + ++ Q + S E +L Q+ Q + EIQA + + ++ + +++
Sbjct: 1535 QE-EVVRREEAAVDAQQQKRSIQE--ELQQLRQSSEAEIQAKARQAEAAERSR--LRIEE 1589
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+++ ++ E R+ + E + EA + Q+E ++L + +
Sbjct: 1590 EIRVVRLQLEAT-------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1642
Query: 1150 SGQDMFRETIQNLSRI------IREKDIEIDALSQ------------------KCQTLLA 1185
Q + ++ SR+ REK + AL + + + +
Sbjct: 1643 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1702
Query: 1186 VLQTSSTGNEAG--------GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
L+T+ EA + Q E LQE Q+++ E + Q + +
Sbjct: 1703 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1762
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
E A+ + E QL+A + +LQ + +S Q E + ++ + + +
Sbjct: 1763 E-AERELERWQLKANEAL----RLRLQAEEVAQQKSLAQAEAE-----KQKEEAEREARR 1812
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
++ + + ++ +L L +A+ A+ +QEL LR +
Sbjct: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA------------EQELIRLRAETE 1860
Query: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL---QKLLKEKDL 1414
+ + + L+E RL AA ++ + ++ ++E+ +++ + +VL + +E+
Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQ----KRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Query: 1415 LIKAKSDQLLSSNEN-FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIV---- 1469
KS Q L + F E LR K + + E D + + E E+++
Sbjct: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976
Query: 1470 ----ETYRGKETEYQALQET---NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
E R K AL+E N + + ++ F+ ++E+A + ++E+
Sbjct: 1977 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 2036
Query: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
+ L K + E T+ +++ ++ +LALK + A + E++ L RSN E
Sbjct: 2037 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE-LELGRIRSNAEDT 2095
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
E E + R+ A E+R + EE++ S A E A+ Q +E ++
Sbjct: 2096 LRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQRKAALEEVE 2149
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
+ +K + L+ QE +Q L A+ QK+L
Sbjct: 2150 R---LKAKVEEARRLRERAEQESARQLQL---------------------AQEAAQKRLQ 2185
Query: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNE 1755
AE K +A ++ K LQ+ L + + LD E E+ EE + Q E
Sbjct: 2186 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2238
Score = 92.8 bits (229), Expect = 3e-18
Identities = 131/757 (17%), Positives = 311/757 (41%), Gaps = 65/757 (8%)
Query: 41 GTEEVEAELPDSRTKEIEAIHAILRSENE--RLKKLCTDLEEKHEASEIQIKQQSTSYRN 98
G E+E EL R+ + + + ++E E R ++L + E + +E ++++ +
Sbjct: 2077 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+Q++ + ++ + +++ + A Q + A H A
Sbjct: 2137 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2196
Query: 159 DDDMDFGDIISSQQEI-NRLSNEVS---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+ + + +Q + ++L E R E R A+ AQ +++E
Sbjct: 2197 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE---- 2252
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
LKQ+ ++ + + ++ E +RR + E + ++ + + +
Sbjct: 2253 -----RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEME 2305
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
E L + ++++ + L+++ E+ + L+++++ + + + A R +
Sbjct: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2365
Query: 335 EQEQLNVEKRQIME-----ECENLKLECSK-------LQPSAVKQSDTMTEKERILAQSA 382
E + V+ ++ + E EN L LQ A K E R+ S
Sbjct: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL---SV 2422
Query: 383 SVEEVFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL------- 433
+ +E RL+Q + A+ + L + ++ +LK E+L+++K L
Sbjct: 2423 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2482
Query: 434 LSQEKEELQMSLLKLNNEYE-VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
L ++KE++ L + ++ +++ R + + +E RL L E Q+ +E++
Sbjct: 2483 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE--RLKLRVAEMSRAQARAEEDA 2540
Query: 493 L-----IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---DLNDEKKRVH 544
EI E + + AT+ + + L Q+ + D +L++ +L EK+++
Sbjct: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2600
Query: 545 QLEDDKMDITKE--LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSI 602
Q E + + E VQ+E+L+Q AL L+++ + E ++Q E
Sbjct: 2601 Q-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2659
Query: 603 QKENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+ + L+E ++ ++++ + R L+ S+ + ++ EAE +++ EL
Sbjct: 2660 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR--------RQHEAE-EGVRRKQEEL 2710
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
+QL + ++ + EN++L + + Q LA + +++ + +TL + +
Sbjct: 2711 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+ A+ + + + + + L A L+ LQ
Sbjct: 2771 DGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2807
Score = 83.2 bits (204), Expect = 2e-15
Identities = 194/1114 (17%), Positives = 417/1114 (37%), Gaps = 196/1114 (17%)
Query: 734 EEANKYEKTIEELSNARNLNTSALQLEHEHLIKL----------------NQKKDMEIAE 777
+E ++ ++ I EL + R L A + H ++L QK E+
Sbjct: 1114 QEESRCQRCISELKDIR-LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1172
Query: 778 LKKNIEQMDTDHKET---------KDVLSSSLE-EQKQLTQLINKKEIFIEKLKERSSKL 827
L K + ++ + ++ L S LE +L Q+ + I++EKLK S +
Sbjct: 1173 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1232
Query: 828 ------QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
+E L + + L++ + + T+ E + + S+K +LR + P
Sbjct: 1233 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-----------KLRAQAEAQQP 1281
Query: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
D L E+ + E L++ +E + QLL+ Q + D
Sbjct: 1282 TFDA--------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1333
Query: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE-ERQDIQTDNSDIFQETKVQ 1000
+ + EQ+ + + E + + + + + + Q+ D Q + QE +
Sbjct: 1334 VRQRELEQLGR-QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1392
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
IE EK + + ++ + IK+ EL++ + L K +V ++
Sbjct: 1393 E-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1448
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
+ Q+ ++++ ++ +++ + +Q + ++ + L+ E E+ + ++
Sbjct: 1449 VIQEYVDLRTHYSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1507
Query: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
K + A A + + E K+L R + ++R ++ +DA
Sbjct: 1508 KQRQLAEAHAQAKAQAEREAKELQQRMQEE--------------VVRREEAAVDA----- 1548
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+QQ + ++E QQ+ Q A
Sbjct: 1549 ----------------------------------QQQKRSIQEELQQLR------QSSEA 1568
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
++Q + Q +A S+L+++ + + T+ + G E
Sbjct: 1569 EIQAKARQAEAA------ERSRLRIEEEIRVVRLQLEATERQRGGAE------------- 1609
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
G+L + + A Q+ E + +V ES Q E+E + E +
Sbjct: 1610 ------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1663
Query: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
A +E L + E E +E+++ ++ Q L+ + + +++K
Sbjct: 1664 AA----REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1719
Query: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
+ E + AV L+E + + ++ E R +E +
Sbjct: 1720 ASFAEKTAQLERSLQEEHV---AVAQLRE----------EAERRAQQQAEAERAREEAER 1766
Query: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
L+ +K + LR + ++K+LA + K+KE+ + + ++++++ +
Sbjct: 1767 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826
Query: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Q+ Q LA Q + A + E+ RLR + + Q+ + L L + REA
Sbjct: 1827 AEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ----REAA 1881
Query: 1601 AA----EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
AA ++ EA+L K +E L S + A E + + + L+ + + +E A
Sbjct: 1882 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1941
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK--QKQLIAEWKKNAENLEG 1714
++++E +Q L+ +E+ A AE E+ ++L A + E
Sbjct: 1942 RLRALAEEAKRQRQLA------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989
Query: 1715 KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
++ L E A + RL E + ++EE Q++ D++++L L +
Sbjct: 1990 EI-----ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA------DIEERLAQLRKA 2038
Query: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGS 1808
S+ ++++ + L + E+L L S
Sbjct: 2039 SDSELER--QKGLVEDTLRQRRQVEEEILALKAS 2070
Score = 70.1 bits (170), Expect = 2e-11
Identities = 268/1447 (18%), Positives = 557/1447 (38%), Gaps = 159/1447 (10%)
Query: 474 LNLEAKEQELNQSISEKET-LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
L++E + +L+ +I E+E L +E E L+ + TK + + +Q N+ D+++
Sbjct: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTK-LQMEAGLCEEQLNQADALLQSD 559
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ L K + ++ ++LD + + +I+ + ND+ K + E + ++
Sbjct: 560 VRLLAAGK-----VPQRAGEVERDLD-KADSMIR--LLFNDVQTLKDGRHPQGEQMYRRV 611
Query: 593 NKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLK---- 645
+ E V+I+ E NL LK + +++++ + +Q + DS + LL
Sbjct: 612 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEE 671
Query: 646 --------EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
E ++ +++ L L++++++ ++ R +CL
Sbjct: 672 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL 731
Query: 698 AGNNQLSLEKNTIVETLKMEKGEIEAE---LCWAKKRLLEEANKYEKTIEELSNARNLNT 754
+L L+ ++ + K +E+ + A K L+ K E+ + + RN N
Sbjct: 732 G---RLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNM 788
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQM-DTDHKETKDVLSSSLEEQKQLTQLINKK 813
+A + + L++ + K+ +I EL+ +++ DH V S Q Q + ++
Sbjct: 789 TAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLC 848
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
LKE ++ Q D ++E LQ+ E LR
Sbjct: 849 CCIEAHLKENAAYFQFFSD-------------------------VREAEGQLQKLQEALR 883
Query: 874 EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE-------DQNQSK 926
+ S + D + + E QLN K HL K + +++ + +
Sbjct: 884 RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 943
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQM------------------NATHTQLFL------EKD 962
+ LL ++ E+ + Q+ A + FL E
Sbjct: 944 LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 1003
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
E + L+ + + T H+ D+++ + VQ + + + L K E +R
Sbjct: 1004 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTL-KPEEQRQA 1062
Query: 1023 KGIKERELEIKLLNEKNISLTKQIDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHT 1081
E + L + ++ D+L ++ E G + QQ +Q+L S
Sbjct: 1063 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRC 1119
Query: 1082 QDVV--YLQQQLQAYAMEREKVFAVL----NEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Q + +LQ A E V + E RE + E K V + +
Sbjct: 1120 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1179
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS----QKCQTLLAVLQTSS 1191
L E +K+ E S T+++ + K ++ +LS +K +T+ V++ +
Sbjct: 1180 LSAEAEKVLALPEPSPA---APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1236
Query: 1192 TGNEAGGVNSNQFEE------LLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
E + Q +E L E + K +KK+ + T ++ E QE
Sbjct: 1237 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1296
Query: 1246 LHQLQ-------AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
+LQ +V + ++L + ++ + + +L+ G++L + S L
Sbjct: 1297 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1356
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSA-ECLRASKSEVLSESSELLQQELEELRKSLQ 1357
L Q+ + L Q+ E LR + + L E E +++EE ++ +
Sbjct: 1357 ----GAWLQDARRRQEQIQAMPLADSQAVREQLR--QEQALLEEIERHGEKVEECQRFAK 1410
Query: 1358 EKDATIR--TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+ I+ LQ ++ A+ + K ++S I++ + + +L
Sbjct: 1411 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
IK S+ L E E L Q +ER+ +E + K + E +
Sbjct: 1471 IKFISETLRRMEE-------EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1523
Query: 1476 ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
E E + LQ+ + ++R +E + ++K + ++ L++ Q E+ ++
Sbjct: 1524 EREAKELQQRMQE--EVVRREEAAVDAQQQKR-SIQEELQQLRQSSEAEIQAKARQAEAA 1580
Query: 1536 QEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRNHL 1588
+ + ++E V L L+ + + + E+Q LR + + ++ +E ERLR +
Sbjct: 1581 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1640
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
+D R+ A + ++++ + EK + A+E QA + E Q V
Sbjct: 1641 ---QDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQAE-EAERRLRQAEVE 1695
Query: 1649 SKQRDETALQLS--VSQEQVKQYALSLANLQMVLEHFQQEEK---AMYSAELEKQKQLIA 1703
++ + AL+ + ++ +++ S A LE QEE A E E++ Q A
Sbjct: 1696 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1755
Query: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
E ++ E E ++ Q +EA A + +Q + + + E+ K + E
Sbjct: 1756 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1815
Query: 1764 VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHD 1823
+++ + +E +++K R L G E++RL + E+ QL +
Sbjct: 1816 AEEQAVRQRELAEQELEK--QRQLAEGTAQQRLAAEQELIRLRAET--EQGEQQRQLLEE 1871
Query: 1824 DQGGVTR 1830
+ + R
Sbjct: 1872 ELARLQR 1878
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 178 bits (452), Expect = 4e-44
Identities = 346/1697 (20%), Positives = 687/1697 (40%), Gaps = 229/1697 (13%)
Query: 170 SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS-------EICKLQNIIKELK 222
+Q E+ L V+RL +E + + S A T S+ ++ L I E
Sbjct: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1066
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET 282
+ S I Q VL+ AH+++L E ++ L + E L+ L Q +
Sbjct: 1067 KTISLVIRGTQGAEEVLR-AHEEQLKE-AQAVPATLPELEATKASLKKLRAQAEAQQPTF 1124
Query: 283 DL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
D ++ Q+ + LQ E ++E+ +++ + ++ + D+ +RE EQL
Sbjct: 1125 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1184
Query: 341 VEKRQIMEECENL-----KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395
+ R E + L + Q A+ +D+ +E++ + A +EE+ R + +
Sbjct: 1185 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1244
Query: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455
+ + + + +D L K ++ +K + E + + L Y +
Sbjct: 1245 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1304
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILI 514
+ ++ I SE LR +E +E+ Q +E+ +AE+E L++Q Q A H
Sbjct: 1305 TTLTSQYIKFISET--LR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA--- 1358
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+K Q E ++ +L+Q + +E R + D Q+++ IQ E L
Sbjct: 1359 ---QAKAQAEREA--KELQQRMQEEVVRREEAAVDAQ--------QQKRSIQEE-----L 1400
Query: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD 634
+Q E +++ Q ++ S + I++E ++ + E + EL +
Sbjct: 1401 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1460
Query: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDVR 690
+ + +E +R Q+ S+ ++ E + K + E ++ + A E++R
Sbjct: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520
Query: 691 HQLEECLAGNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
Q EE Q +E+ V+ L+ + EAEL + E+ + E++++E
Sbjct: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE--- 1577
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIA--ELKKNIE--QMDTDHKETKDVLSSSLEEQKQ 805
+ + QL E + Q+ + E A E ++ +E Q+ + + + + +QK
Sbjct: 1578 ---HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634
Query: 806 LTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
L Q K++ E+ R K +E QA+R+ E+ Q +E++ + ++
Sbjct: 1635 LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLA 1688
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
++EL RLR E TE + QL LEEE+ Q+ Q
Sbjct: 1689 AEQELIRLRAE----------------TEQGEQQRQL------LEEELARLQREAAAATQ 1726
Query: 925 SKMQLLQSLQEQKKEMD-----EFRYQHEQMNATHTQL---------FLEKDEEIKSLQK 970
+ +L L + + EM+ + R + E + + F E EE L+
Sbjct: 1727 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1786
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
E+ K Q +D Q + + + E + + ++ +TE + +KE+E
Sbjct: 1787 LAEEAKRQRQLAEEDAAR------QRAEAERVLAEKLAAIGEATRLKTEAEI-ALKEKEA 1839
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
E +++ +L++DE Q++ LE QA H D+ Q
Sbjct: 1840 E-----------NERLRRLAEDEA------FQRRRLEEQA-------AQHKADIEERLAQ 1875
Query: 1091 LQ-AYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
L+ A E E+ ++ + R+ ++ E ++ + A+ E A + +L R S
Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEE---ILALKASFEKAAAGKAELELELG-RIRS 1931
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+ +D R Q R++ + + ++ + V ++ + EA + Q + L+
Sbjct: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA----ARQRKAALE 1987
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTG 1269
E ++LK +V++ +++ QE QLQ L +LQ +
Sbjct: 1988 EVERLKAKVEEARRLRERAE-------------QESARQLQ---LAQEAAQKRLQAEEKA 2031
Query: 1270 LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD------IISPQLSSASLLT 1323
+ +Q E +L+ Q L Q Q + QL + + + + + ++ S
Sbjct: 2032 HAFAVQQKEQELQ---QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088
Query: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
+ AE L+ S E ++ Q E+LRK +++ A R Q L AA +E+
Sbjct: 2089 VEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEM 2145
Query: 1384 ER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
E+ K EQT + Q++++ L+ L+E D ++L T + +
Sbjct: 2146 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2205
Query: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE------ 1495
+ + +++ ++ L +++ EN ++ R K+ + LQE K + E
Sbjct: 2206 EELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2263
Query: 1496 --------KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER- 1546
++ + ++ E++LKEK Q A Q+K + +Q R
Sbjct: 2264 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2323
Query: 1547 ---DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
D+ +A +Q E Q ++ R ++ + E ERL+ + E + R AE
Sbjct: 2324 LQEDKEQMA-QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR----AE 2378
Query: 1604 DREAKLRKKVTVLEEKL----------VSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
+ + RK+ + EKL V+ +E Q+ E L+E + + ++++
Sbjct: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
Query: 1654 ETA-----LQL------SVSQEQV-------KQYALSLANLQMVLEHFQQEEKA----MY 1691
+ LQL +V QEQ+ +Q LS + + E F ++EKA ++
Sbjct: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
E+ K +QL E ++ + +E + L ++EA A + + +Q+E+ +
Sbjct: 2499 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2558
Query: 1752 RQNELRQEMLDDVQKKL 1768
RQ E E+L + ++L
Sbjct: 2559 RQQE---ELLAEENQRL 2572
Score = 159 bits (402), Expect = 3e-38
Identities = 292/1451 (20%), Positives = 593/1451 (40%), Gaps = 171/1451 (11%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHE 83
A L S K + G+E V E D RT E L + + K ++ + E
Sbjct: 1269 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTTLTSQYIKFISETLRRME 1323
Query: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
E +QQ R +L EVE + K RQ+A K Q+ ++ +
Sbjct: 1324 EEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
Query: 144 SSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL----ESEVGHWRHIAQTSK 199
A + +QQ+ + E+ +L E+E+ A+ ++
Sbjct: 1382 REEA-------------------AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1422
Query: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
++ + +LQ E ++ ++ + A +++ E + R R ++
Sbjct: 1423 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1482
Query: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ---IEKVESTKKMEQLE-DKI 315
D +R + E L + ++ + E Q+ +Q L+ ++ E+ +++ Q E ++
Sbjct: 1483 DESQRKRQAEVEL----ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1538
Query: 316 KDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+ + L +A+ R + +L ++ E+ L+ LQ V + E E
Sbjct: 1539 RQVQVALETAQ------RSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAE 1589
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R Q A E +A +AE E+ R A + L+L+++ E + ++KSL
Sbjct: 1590 RRAQQQAEAE------RAREEAERELERWQLK------ANEALRLRLQAEEVAQQKSLAQ 1637
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISL-DSELHDLRLNLEAKEQELNQSISEKETLI 494
E E+ + + + A R L + EL R E Q+ + E L
Sbjct: 1638 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1697
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
AE E+ ++Q Q L++++L++ Q E + K +Q+L E +V
Sbjct: 1698 AETEQGEQQRQ-------LLEEELARLQREAAAATQK-RQELEAELAKVR---------- 1739
Query: 555 KELDVQKEKLIQSEV-ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
+ E L+ S+ A + T +K + ++E + + E ++ E K
Sbjct: 1740 ----AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795
Query: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
+ EE+ +R R E + L + + + T LK EAE+ LK+ +E NE L+++A
Sbjct: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIA-LKEKEAE----NERLRRLAE 1849
Query: 674 DVKMENEKLVLACEDVRHQLEECL-----AGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
D + +L + +EE L A +++L +K + +TL+ ++ ++E E+ A
Sbjct: 1850 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEEEIL-A 1907
Query: 729 KKRLLEEANKYEKTIE-ELSNARNLNTSAL------QLEHEHLIKLNQKKDMEIAELKKN 781
K E+A + +E EL R+ L +LE +L +++ E ++
Sbjct: 1908 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967
Query: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSK----LQEELDKYSQA 837
+++ +E ++LEE ++L + + E+ ++ S++ QE K QA
Sbjct: 1968 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2027
Query: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASE 897
K +++K++ L ++ + ++L E R A A+ + + E A
Sbjct: 2028 EEKAHAF--AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
Query: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Q+ EE + ++ E+Q Q++ Q + ++ +KE ++ + Q +
Sbjct: 2086 RRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2137
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDI--------QTDNSDIFQETKVQSLNIENGSE 1009
D E++ +K EQ Q + Q++ +TD+ + ++Q L E
Sbjct: 2138 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2197
Query: 1010 KHDLSKAETERLVKGIKERE---LEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQQ 1063
S+ E E ++ E L+ ++ E + + D + +E K+ Q+ ++
Sbjct: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2257
Query: 1064 -KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
L + A A +D+ QQ+ A M +EK+ AV +E + LK E +
Sbjct: 2258 AARLSVAAQEAARLRQLAEEDLA--QQRALAEKMLKEKMQAV-----QEATRLKAEAELL 2310
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKC 1180
KE A Q++ ++L E Q + ET Q R++ +E+ A +++
Sbjct: 2311 QQ---QKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2363
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+ +A + + E + ++ +++ +++ + E Q+ +T VQ ++ +
Sbjct: 2364 KLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2417
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Q + +L+ + KLQ + L ++S E + + QE +Q S
Sbjct: 2418 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS---FL 2474
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK----S 1355
+ KD LL + I + + L +K++ L E + QQ++E+ R+ S
Sbjct: 2475 SEKDSLLQRERFIEQEKAKLEQLFQD-----EVAKAQQLREEQQRQQQQMEQERQRLVAS 2529
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++E +E R + + + R++ E E ++L+E+ +LL+E+
Sbjct: 2530 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ----LQLLEEQHRA 2585
Query: 1416 IKAKSDQLLSS 1426
A S+++ +S
Sbjct: 2586 ALAHSEEVTAS 2596
Score = 128 bits (322), Expect = 5e-29
Identities = 319/1545 (20%), Positives = 631/1545 (40%), Gaps = 244/1545 (15%)
Query: 467 SELHDLRLNLEAKE----------------QELNQSISEKETLIAEIEELD----RQNQE 506
SEL D+RL LEA E +E Q I+E++ AE+E L R + E
Sbjct: 965 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1024
Query: 507 ATKHMILIKDQLSKQ--QNEGDSIISKLKQDLN------DEKKRVHQLEDDKMDITKELD 558
A K + L + + ++E + + KL+Q + ++ K + + + L
Sbjct: 1025 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1084
Query: 559 VQKEKLIQSE---VALNDLHLTKQKL----------EDKVENLVDQLNKSQESNVSIQKE 605
+E+L +++ L +L TK L + + L D+L +QE +Q+
Sbjct: 1085 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1144
Query: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQN-------L 658
+ E + + E ++++ L Q ++ + L++ ++R +++ L
Sbjct: 1145 HGERDVEVERWRERVAQLLERWQAVLAQ---TDVRQRELEQLGRQLRYYRESADPLGAWL 1201
Query: 659 SELEQLNENLKKVAF-DVKMENEKL----VLACEDVRH--QLEECLAGNNQLSLEKNTIV 711
+ + E ++ + D + E+L L E RH ++EEC Q
Sbjct: 1202 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1261
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
L K ++E AKK ++ + E I+E + R + L ++ IK +
Sbjct: 1262 LQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQY-IKFISET 1318
Query: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK-LKERSSKLQEE 830
+ E ++ EQ + +E + ++LE+Q+QL + + + E+ KE ++QEE
Sbjct: 1319 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1378
Query: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ----EELERLR---EEQSRTAPVA 883
+ + +A + +++I+E+ + L E + E ER R EE+ R +
Sbjct: 1379 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1438
Query: 884 DPKT-------LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL--- 933
T + L + + K +EE + ++ ++D++Q K Q L
Sbjct: 1439 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498
Query: 934 -----------QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK-SLQKTIEQIKTQLHE 981
Q + ++E R Q E+ Q +E+ +++ +L+ + +L
Sbjct: 1499 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
Query: 982 ERQDIQTDNSDI---FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELE------- 1031
+R + + QE V + +E+ +AE ER + ERELE
Sbjct: 1559 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER-AREEAERELERWQLKAN 1617
Query: 1032 --IKL-LNEKNISLTKQIDQL----SKDEV-------GKL-TQIIQQKDLEIQALHARIS 1076
++L L + ++ K + Q K+E GK Q ++Q++L Q L +
Sbjct: 1618 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
Query: 1077 STSHT--------QDVVYL-------QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 1121
T Q+++ L +QQ Q E ++ T++ L+ E K
Sbjct: 1678 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1737
Query: 1122 ----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI-------IREKD 1170
M ++A+K A + + ++K R E+ FRE + +R+ R++
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAEEAARLRALAEEAKRQRQ 1796
Query: 1171 I-EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM--EEWKQQ 1227
+ E DA Q+ + + + + EA + + + E L+E++ ++++++ +E Q+
Sbjct: 1797 LAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDEAFQR 1855
Query: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Q QH+ A ++E L QL+ + + L D + E+ LK ++
Sbjct: 1856 RRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1914
Query: 1288 L----AQVQHSIGQL-CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
A+++ +G++ N +D L K +L +A + E R ++E + S
Sbjct: 1915 AAAGKAELELELGRIRSNAEDTLRSK---EQAELEAARQRQLAAEEERRRREAEERVQKS 1971
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS---------------ELERKE 1387
++E RK+ E+ ++ E RL + S + E K
Sbjct: 1972 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2031
Query: 1388 H----EQTDSEIKQ-LKEKQDVLQKLLKEKDLLIKAKSD------QLLSSNENFTNKVNE 1436
H +Q + E++Q L+++Q VL +L E + +A + Q +V E
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2091
Query: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
E L+Q+ + + KL+ E E+ E R + E AL++ + M + K
Sbjct: 2092 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHK 2149
Query: 1497 EFECHSMKEKALAFEQL--LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV--MLA 1552
+F ++++KA ++L L+ + + + N L ++ ++ + ++R QV L
Sbjct: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2209
Query: 1553 LKQKQMENTA-------LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED- 1604
+ QME + +N LRDK+ + + L+ + + + R ++AA++
Sbjct: 2210 SVRVQMEELSKLKARIEAENRALILRDKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268
Query: 1605 ------REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
E L ++ + E+ L A++ A+ + + E LQ+Q + +Q A +
Sbjct: 2269 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQEQ----ARR 2323
Query: 1659 LSVSQEQV-KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW-------KKNAE 1710
L +EQ+ +Q A Q LE +Q + M SAE E+ K +AE +++A+
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQ 2382
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ-----------IEELKRQNE---- 1755
+ + E L A L + L+++ +Q I EL+R+ E
Sbjct: 2383 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442
Query: 1756 ------LRQEMLDDVQKKLM-----SLANSSEGKVDKVLMRNLFI 1789
L+ E + VQ++ + +L S + D +L R FI
Sbjct: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2487
Score = 119 bits (298), Expect = 3e-26
Identities = 237/1253 (18%), Positives = 497/1253 (39%), Gaps = 200/1253 (15%)
Query: 586 ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
+ L+ L + + Q+ ELK+ Q E +R + L L+++ + +
Sbjct: 944 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1003
Query: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL------ACEDVRHQLEECLAG 699
+++A+ +E+E L + + +++ E EK++ A +R +LE L
Sbjct: 1004 QQKAQ--------AEVEGLGKGVARLS----AEAEKVLALPEPSPAAPTLRSELELTLGK 1051
Query: 700 NNQLSLEKNTIVETLKMEKGEIEA-----ELCWAKKRLLEEANKYEKTIEELSNARNLNT 754
Q+ +E LK I E+ A + L+EA T+ EL +
Sbjct: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK---- 1107
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ +L+ E +D L + E ++L Q +++
Sbjct: 1108 ------------------ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1149
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE--RL 872
+ +E+ +ER ++L L+++ L + ++ ++ +E+ R L +E + L L+ R
Sbjct: 1150 VEVERWRERVAQL---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1206
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
R+EQ + P+AD + + QL + LEE +H +K+ E Q +K Q + +
Sbjct: 1207 RQEQIQAMPLADSQAVRE---------QLRQEQALLEEIERHGEKVEECQRFAK-QYINA 1256
Query: 933 LQEQKKEMDEFRYQHE-----------------------QMNATHTQLFLEKDEEIKSLQ 969
+++ + ++ ++ Q E + +++L + IK +
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
Query: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
+T+ +++ + Q + + + E + +E H +KA+ ER K +++R
Sbjct: 1317 ETLRRMEEEERLAEQQ-RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1375
Query: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
E +++ + ++ Q + S E +L Q+ Q + EIQA + + ++ + +++
Sbjct: 1376 QE-EVVRREEAAVDAQQQKRSIQE--ELQQLRQSSEAEIQAKARQAEAAERSR--LRIEE 1430
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+++ ++ E R+ + E + EA + Q+E ++L + +
Sbjct: 1431 EIRVVRLQLEAT-------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1483
Query: 1150 SGQDMFRETIQNLSRI------IREKDIEIDALSQ------------------KCQTLLA 1185
Q + ++ SR+ REK + AL + + + +
Sbjct: 1484 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1543
Query: 1186 VLQTSSTGNEAG--------GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
L+T+ EA + Q E LQE Q+++ E + Q + +
Sbjct: 1544 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1603
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
E A+ + E QL+A + +LQ + +S Q E + ++ + + +
Sbjct: 1604 E-AERELERWQLKANEAL----RLRLQAEEVAQQKSLAQAEAE-----KQKEEAEREARR 1653
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
++ + + ++ +L L +A+ A+ +QEL LR +
Sbjct: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA------------EQELIRLRAETE 1701
Query: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL---QKLLKEKDL 1414
+ + + L+E RL AA ++ + ++ ++E+ +++ + +VL + +E+
Sbjct: 1702 QGEQQRQLLEEELARLQREAAAATQ----KRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Query: 1415 LIKAKSDQLLSSNEN-FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIV---- 1469
KS Q L + F E LR K + + E D + + E E+++
Sbjct: 1758 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1817
Query: 1470 ----ETYRGKETEYQALQET---NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
E R K AL+E N + + ++ F+ ++E+A + ++E+
Sbjct: 1818 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1877
Query: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
+ L K + E T+ +++ ++ +LALK + A + E++ L RSN E
Sbjct: 1878 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE-LELGRIRSNAEDT 1936
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
E E + R+ A E+R + EE++ S A E A+ Q +E ++
Sbjct: 1937 LRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQRKAALEEVE 1990
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
+ +K + L+ QE +Q L A+ QK+L
Sbjct: 1991 R---LKAKVEEARRLRERAEQESARQLQL---------------------AQEAAQKRLQ 2026
Query: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNE 1755
AE K +A ++ K LQ+ L + + LD E E+ EE + Q E
Sbjct: 2027 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2079
Score = 92.8 bits (229), Expect = 3e-18
Identities = 131/757 (17%), Positives = 311/757 (41%), Gaps = 65/757 (8%)
Query: 41 GTEEVEAELPDSRTKEIEAIHAILRSENE--RLKKLCTDLEEKHEASEIQIKQQSTSYRN 98
G E+E EL R+ + + + ++E E R ++L + E + +E ++++ +
Sbjct: 1918 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+Q++ + ++ + +++ + A Q + A H A
Sbjct: 1978 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2037
Query: 159 DDDMDFGDIISSQQEI-NRLSNEVS---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+ + + +Q + ++L E R E R A+ AQ +++E
Sbjct: 2038 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE---- 2093
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
LKQ+ ++ + + ++ E +RR + E + ++ + + +
Sbjct: 2094 -----RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEME 2146
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
E L + ++++ + L+++ E+ + L+++++ + + + A R +
Sbjct: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2206
Query: 335 EQEQLNVEKRQIME-----ECENLKLECSK-------LQPSAVKQSDTMTEKERILAQSA 382
E + V+ ++ + E EN L LQ A K E R+ S
Sbjct: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL---SV 2263
Query: 383 SVEEVFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL------- 433
+ +E RL+Q + A+ + L + ++ +LK E+L+++K L
Sbjct: 2264 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2323
Query: 434 LSQEKEELQMSLLKLNNEYE-VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
L ++KE++ L + ++ +++ R + + +E RL L E Q+ +E++
Sbjct: 2324 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE--RLKLRVAEMSRAQARAEEDA 2381
Query: 493 L-----IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---DLNDEKKRVH 544
EI E + + AT+ + + L Q+ + D +L++ +L EK+++
Sbjct: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2441
Query: 545 QLEDDKMDITKE--LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSI 602
Q E + + E VQ+E+L+Q AL L+++ + E ++Q E
Sbjct: 2442 Q-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2500
Query: 603 QKENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+ + L+E ++ ++++ + R L+ S+ + ++ EAE +++ EL
Sbjct: 2501 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR--------RQHEAE-EGVRRKQEEL 2551
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
+QL + ++ + EN++L + + Q LA + +++ + +TL + +
Sbjct: 2552 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+ A+ + + + + + L A L+ LQ
Sbjct: 2612 DGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2648
Score = 83.2 bits (204), Expect = 2e-15
Identities = 194/1114 (17%), Positives = 417/1114 (37%), Gaps = 196/1114 (17%)
Query: 734 EEANKYEKTIEELSNARNLNTSALQLEHEHLIKL----------------NQKKDMEIAE 777
+E ++ ++ I EL + R L A + H ++L QK E+
Sbjct: 955 QEESRCQRCISELKDIR-LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1013
Query: 778 LKKNIEQMDTDHKET---------KDVLSSSLE-EQKQLTQLINKKEIFIEKLKERSSKL 827
L K + ++ + ++ L S LE +L Q+ + I++EKLK S +
Sbjct: 1014 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1073
Query: 828 ------QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
+E L + + L++ + + T+ E + + S+K +LR + P
Sbjct: 1074 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-----------KLRAQAEAQQP 1122
Query: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
D L E+ + E L++ +E + QLL+ Q + D
Sbjct: 1123 TFDA--------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1174
Query: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE-ERQDIQTDNSDIFQETKVQ 1000
+ + EQ+ + + E + + + + + + Q+ D Q + QE +
Sbjct: 1175 VRQRELEQLGR-QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1233
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
IE EK + + ++ + IK+ EL++ + L K +V ++
Sbjct: 1234 E-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1289
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
+ Q+ ++++ ++ +++ + +Q + ++ + L+ E E+ + ++
Sbjct: 1290 VIQEYVDLRTHYSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1348
Query: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
K + A A + + E K+L R + ++R ++ +DA
Sbjct: 1349 KQRQLAEAHAQAKAQAEREAKELQQRMQEE--------------VVRREEAAVDA----- 1389
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+QQ + ++E QQ+ Q A
Sbjct: 1390 ----------------------------------QQQKRSIQEELQQLR------QSSEA 1409
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
++Q + Q +A S+L+++ + + T+ + G E
Sbjct: 1410 EIQAKARQAEAA------ERSRLRIEEEIRVVRLQLEATERQRGGAE------------- 1450
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
G+L + + A Q+ E + +V ES Q E+E + E +
Sbjct: 1451 ------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1504
Query: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
A +E L + E E +E+++ ++ Q L+ + + +++K
Sbjct: 1505 AA----REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560
Query: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
+ E + AV L+E + + ++ E R +E +
Sbjct: 1561 ASFAEKTAQLERSLQEEHV---AVAQLRE----------EAERRAQQQAEAERAREEAER 1607
Query: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
L+ +K + LR + ++K+LA + K+KE+ + + ++++++ +
Sbjct: 1608 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1667
Query: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Q+ Q LA Q + A + E+ RLR + + Q+ + L L + REA
Sbjct: 1668 AEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ----REAA 1722
Query: 1601 AA----EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
AA ++ EA+L K +E L S + A E + + + L+ + + +E A
Sbjct: 1723 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1782
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK--QKQLIAEWKKNAENLEG 1714
++++E +Q L+ +E+ A AE E+ ++L A + E
Sbjct: 1783 RLRALAEEAKRQRQLA------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830
Query: 1715 KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
++ L E A + RL E + ++EE Q++ D++++L L +
Sbjct: 1831 EI-----ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA------DIEERLAQLRKA 1879
Query: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGS 1808
S+ ++++ + L + E+L L S
Sbjct: 1880 SDSELER--QKGLVEDTLRQRRQVEEEILALKAS 1911
Score = 70.1 bits (170), Expect = 2e-11
Identities = 268/1447 (18%), Positives = 557/1447 (38%), Gaps = 159/1447 (10%)
Query: 474 LNLEAKEQELNQSISEKET-LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
L++E + +L+ +I E+E L +E E L+ + TK + + +Q N+ D+++
Sbjct: 342 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTK-LQMEAGLCEEQLNQADALLQSD 400
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ L K + ++ ++LD + + +I+ + ND+ K + E + ++
Sbjct: 401 VRLLAAGK-----VPQRAGEVERDLD-KADSMIR--LLFNDVQTLKDGRHPQGEQMYRRV 452
Query: 593 NKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLK---- 645
+ E V+I+ E NL LK + +++++ + +Q + DS + LL
Sbjct: 453 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEE 512
Query: 646 --------EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
E ++ +++ L L++++++ ++ R +CL
Sbjct: 513 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL 572
Query: 698 AGNNQLSLEKNTIVETLKMEKGEIEAE---LCWAKKRLLEEANKYEKTIEELSNARNLNT 754
+L L+ ++ + K +E+ + A K L+ K E+ + + RN N
Sbjct: 573 G---RLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNM 629
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQM-DTDHKETKDVLSSSLEEQKQLTQLINKK 813
+A + + L++ + K+ +I EL+ +++ DH V S Q Q + ++
Sbjct: 630 TAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLC 689
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
LKE ++ Q D ++E LQ+ E LR
Sbjct: 690 CCIEAHLKENAAYFQFFSD-------------------------VREAEGQLQKLQEALR 724
Query: 874 EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE-------DQNQSK 926
+ S + D + + E QLN K HL K + +++ + +
Sbjct: 725 RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 784
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQM------------------NATHTQLFL------EKD 962
+ LL ++ E+ + Q+ A + FL E
Sbjct: 785 LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 844
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
E + L+ + + T H+ D+++ + VQ + + + L K E +R
Sbjct: 845 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTL-KPEEQRQA 903
Query: 1023 KGIKERELEIKLLNEKNISLTKQIDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHT 1081
E + L + ++ D+L ++ E G + QQ +Q+L S
Sbjct: 904 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRC 960
Query: 1082 QDVV--YLQQQLQAYAMEREKVFAVL----NEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Q + +LQ A E V + E RE + E K V + +
Sbjct: 961 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1020
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS----QKCQTLLAVLQTSS 1191
L E +K+ E S T+++ + K ++ +LS +K +T+ V++ +
Sbjct: 1021 LSAEAEKVLALPEPSPA---APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1077
Query: 1192 TGNEAGGVNSNQFEE------LLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
E + Q +E L E + K +KK+ + T ++ E QE
Sbjct: 1078 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1137
Query: 1246 LHQLQ-------AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
+LQ +V + ++L + ++ + + +L+ G++L + S L
Sbjct: 1138 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1197
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSA-ECLRASKSEVLSESSELLQQELEELRKSLQ 1357
L Q+ + L Q+ E LR + + L E E +++EE ++ +
Sbjct: 1198 ----GAWLQDARRRQEQIQAMPLADSQAVREQLR--QEQALLEEIERHGEKVEECQRFAK 1251
Query: 1358 EKDATIR--TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+ I+ LQ ++ A+ + K ++S I++ + + +L
Sbjct: 1252 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
IK S+ L E E L Q +ER+ +E + K + E +
Sbjct: 1312 IKFISETLRRMEE-------EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1364
Query: 1476 ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
E E + LQ+ + ++R +E + ++K + ++ L++ Q E+ ++
Sbjct: 1365 EREAKELQQRMQE--EVVRREEAAVDAQQQKR-SIQEELQQLRQSSEAEIQAKARQAEAA 1421
Query: 1536 QEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRNHL 1588
+ + ++E V L L+ + + + E+Q LR + + ++ +E ERLR +
Sbjct: 1422 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1481
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
+D R+ A + ++++ + EK + A+E QA + E Q V
Sbjct: 1482 ---QDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQAE-EAERRLRQAEVE 1536
Query: 1649 SKQRDETALQLS--VSQEQVKQYALSLANLQMVLEHFQQEEK---AMYSAELEKQKQLIA 1703
++ + AL+ + ++ +++ S A LE QEE A E E++ Q A
Sbjct: 1537 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1596
Query: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
E ++ E E ++ Q +EA A + +Q + + + E+ K + E
Sbjct: 1597 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1656
Query: 1764 VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHD 1823
+++ + +E +++K R L G E++RL + E+ QL +
Sbjct: 1657 AEEQAVRQRELAEQELEK--QRQLAEGTAQQRLAAEQELIRLRAET--EQGEQQRQLLEE 1712
Query: 1824 DQGGVTR 1830
+ + R
Sbjct: 1713 ELARLQR 1719
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 178 bits (452), Expect = 4e-44
Identities = 346/1697 (20%), Positives = 687/1697 (40%), Gaps = 229/1697 (13%)
Query: 170 SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS-------EICKLQNIIKELK 222
+Q E+ L V+RL +E + + S A T S+ ++ L I E
Sbjct: 1015 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1074
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET 282
+ S I Q VL+ AH+++L E ++ L + E L+ L Q +
Sbjct: 1075 KTISLVIRGTQGAEEVLR-AHEEQLKE-AQAVPATLPELEATKASLKKLRAQAEAQQPTF 1132
Query: 283 DL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
D ++ Q+ + LQ E ++E+ +++ + ++ + D+ +RE EQL
Sbjct: 1133 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1192
Query: 341 VEKRQIMEECENL-----KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395
+ R E + L + Q A+ +D+ +E++ + A +EE+ R + +
Sbjct: 1193 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1252
Query: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455
+ + + + +D L K ++ +K + E + + L Y +
Sbjct: 1253 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1312
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILI 514
+ ++ I SE LR +E +E+ Q +E+ +AE+E L++Q Q A H
Sbjct: 1313 TTLTSQYIKFISET--LR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA--- 1366
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+K Q E ++ +L+Q + +E R + D Q+++ IQ E L
Sbjct: 1367 ---QAKAQAEREA--KELQQRMQEEVVRREEAAVDAQ--------QQKRSIQEE-----L 1408
Query: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD 634
+Q E +++ Q ++ S + I++E ++ + E + EL +
Sbjct: 1409 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1468
Query: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDVR 690
+ + +E +R Q+ S+ ++ E + K + E ++ + A E++R
Sbjct: 1469 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1528
Query: 691 HQLEECLAGNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
Q EE Q +E+ V+ L+ + EAEL + E+ + E++++E
Sbjct: 1529 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE--- 1585
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIA--ELKKNIE--QMDTDHKETKDVLSSSLEEQKQ 805
+ + QL E + Q+ + E A E ++ +E Q+ + + + + +QK
Sbjct: 1586 ---HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1642
Query: 806 LTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
L Q K++ E+ R K +E QA+R+ E+ Q +E++ + ++
Sbjct: 1643 LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLA 1696
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
++EL RLR E TE + QL LEEE+ Q+ Q
Sbjct: 1697 AEQELIRLRAE----------------TEQGEQQRQL------LEEELARLQREAAAATQ 1734
Query: 925 SKMQLLQSLQEQKKEMD-----EFRYQHEQMNATHTQL---------FLEKDEEIKSLQK 970
+ +L L + + EM+ + R + E + + F E EE L+
Sbjct: 1735 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1794
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
E+ K Q +D Q + + + E + + ++ +TE + +KE+E
Sbjct: 1795 LAEEAKRQRQLAEEDAAR------QRAEAERVLAEKLAAIGEATRLKTEAEI-ALKEKEA 1847
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
E +++ +L++DE Q++ LE QA H D+ Q
Sbjct: 1848 E-----------NERLRRLAEDEA------FQRRRLEEQA-------AQHKADIEERLAQ 1883
Query: 1091 LQ-AYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
L+ A E E+ ++ + R+ ++ E ++ + A+ E A + +L R S
Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEE---ILALKASFEKAAAGKAELELELG-RIRS 1939
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+ +D R Q R++ + + ++ + V ++ + EA + Q + L+
Sbjct: 1940 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA----ARQRKAALE 1995
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTG 1269
E ++LK +V++ +++ QE QLQ L +LQ +
Sbjct: 1996 EVERLKAKVEEARRLRERAE-------------QESARQLQ---LAQEAAQKRLQAEEKA 2039
Query: 1270 LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD------IISPQLSSASLLT 1323
+ +Q E +L+ Q L Q Q + QL + + + + + ++ S
Sbjct: 2040 HAFAVQQKEQELQ---QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2096
Query: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
+ AE L+ S E ++ Q E+LRK +++ A R Q L AA +E+
Sbjct: 2097 VEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEM 2153
Query: 1384 ER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
E+ K EQT + Q++++ L+ L+E D ++L T + +
Sbjct: 2154 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2213
Query: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE------ 1495
+ + +++ ++ L +++ EN ++ R K+ + LQE K + E
Sbjct: 2214 EELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2271
Query: 1496 --------KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER- 1546
++ + ++ E++LKEK Q A Q+K + +Q R
Sbjct: 2272 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2331
Query: 1547 ---DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
D+ +A +Q E Q ++ R ++ + E ERL+ + E + R AE
Sbjct: 2332 LQEDKEQMA-QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR----AE 2386
Query: 1604 DREAKLRKKVTVLEEKL----------VSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
+ + RK+ + EKL V+ +E Q+ E L+E + + ++++
Sbjct: 2387 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2446
Query: 1654 ETA-----LQL------SVSQEQV-------KQYALSLANLQMVLEHFQQEEKA----MY 1691
+ LQL +V QEQ+ +Q LS + + E F ++EKA ++
Sbjct: 2447 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2506
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
E+ K +QL E ++ + +E + L ++EA A + + +Q+E+ +
Sbjct: 2507 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2566
Query: 1752 RQNELRQEMLDDVQKKL 1768
RQ E E+L + ++L
Sbjct: 2567 RQQE---ELLAEENQRL 2580
Score = 159 bits (402), Expect = 3e-38
Identities = 292/1451 (20%), Positives = 593/1451 (40%), Gaps = 171/1451 (11%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHE 83
A L S K + G+E V E D RT E L + + K ++ + E
Sbjct: 1277 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTTLTSQYIKFISETLRRME 1331
Query: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
E +QQ R +L EVE + K RQ+A K Q+ ++ +
Sbjct: 1332 EEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1389
Query: 144 SSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL----ESEVGHWRHIAQTSK 199
A + +QQ+ + E+ +L E+E+ A+ ++
Sbjct: 1390 REEA-------------------AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1430
Query: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
++ + +LQ E ++ ++ + A +++ E + R R ++
Sbjct: 1431 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1490
Query: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ---IEKVESTKKMEQLE-DKI 315
D +R + E L + ++ + E Q+ +Q L+ ++ E+ +++ Q E ++
Sbjct: 1491 DESQRKRQAEVEL----ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1546
Query: 316 KDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+ + L +A+ R + +L ++ E+ L+ LQ V + E E
Sbjct: 1547 RQVQVALETAQ------RSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAE 1597
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R Q A E +A +AE E+ R A + L+L+++ E + ++KSL
Sbjct: 1598 RRAQQQAEAE------RAREEAERELERWQLK------ANEALRLRLQAEEVAQQKSLAQ 1645
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISL-DSELHDLRLNLEAKEQELNQSISEKETLI 494
E E+ + + + A R L + EL R E Q+ + E L
Sbjct: 1646 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1705
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
AE E+ ++Q Q L++++L++ Q E + K +Q+L E +V
Sbjct: 1706 AETEQGEQQRQ-------LLEEELARLQREAAAATQK-RQELEAELAKVR---------- 1747
Query: 555 KELDVQKEKLIQSEV-ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
+ E L+ S+ A + T +K + ++E + + E ++ E K
Sbjct: 1748 ----AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1803
Query: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
+ EE+ +R R E + L + + + T LK EAE+ LK+ +E NE L+++A
Sbjct: 1804 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIA-LKEKEAE----NERLRRLAE 1857
Query: 674 DVKMENEKLVLACEDVRHQLEECL-----AGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
D + +L + +EE L A +++L +K + +TL+ ++ ++E E+ A
Sbjct: 1858 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEEEIL-A 1915
Query: 729 KKRLLEEANKYEKTIE-ELSNARNLNTSAL------QLEHEHLIKLNQKKDMEIAELKKN 781
K E+A + +E EL R+ L +LE +L +++ E ++
Sbjct: 1916 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1975
Query: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSK----LQEELDKYSQA 837
+++ +E ++LEE ++L + + E+ ++ S++ QE K QA
Sbjct: 1976 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2035
Query: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASE 897
K +++K++ L ++ + ++L E R A A+ + + E A
Sbjct: 2036 EEKAHAF--AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2093
Query: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Q+ EE + ++ E+Q Q++ Q + ++ +KE ++ + Q +
Sbjct: 2094 RRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2145
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDI--------QTDNSDIFQETKVQSLNIENGSE 1009
D E++ +K EQ Q + Q++ +TD+ + ++Q L E
Sbjct: 2146 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2205
Query: 1010 KHDLSKAETERLVKGIKERE---LEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQQ 1063
S+ E E ++ E L+ ++ E + + D + +E K+ Q+ ++
Sbjct: 2206 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2265
Query: 1064 -KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
L + A A +D+ QQ+ A M +EK+ AV +E + LK E +
Sbjct: 2266 AARLSVAAQEAARLRQLAEEDLA--QQRALAEKMLKEKMQAV-----QEATRLKAEAELL 2318
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKC 1180
KE A Q++ ++L E Q + ET Q R++ +E+ A +++
Sbjct: 2319 QQ---QKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2371
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+ +A + + E + ++ +++ +++ + E Q+ +T VQ ++ +
Sbjct: 2372 KLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2425
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Q + +L+ + KLQ + L ++S E + + QE +Q S
Sbjct: 2426 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS---FL 2482
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK----S 1355
+ KD LL + I + + L +K++ L E + QQ++E+ R+ S
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQD-----EVAKAQQLREEQQRQQQQMEQERQRLVAS 2537
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++E +E R + + + R++ E E ++L+E+ +LL+E+
Sbjct: 2538 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ----LQLLEEQHRA 2593
Query: 1416 IKAKSDQLLSS 1426
A S+++ +S
Sbjct: 2594 ALAHSEEVTAS 2604
Score = 128 bits (322), Expect = 5e-29
Identities = 319/1545 (20%), Positives = 631/1545 (40%), Gaps = 244/1545 (15%)
Query: 467 SELHDLRLNLEAKE----------------QELNQSISEKETLIAEIEELD----RQNQE 506
SEL D+RL LEA E +E Q I+E++ AE+E L R + E
Sbjct: 973 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1032
Query: 507 ATKHMILIKDQLSKQ--QNEGDSIISKLKQDLN------DEKKRVHQLEDDKMDITKELD 558
A K + L + + ++E + + KL+Q + ++ K + + + L
Sbjct: 1033 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1092
Query: 559 VQKEKLIQSE---VALNDLHLTKQKL----------EDKVENLVDQLNKSQESNVSIQKE 605
+E+L +++ L +L TK L + + L D+L +QE +Q+
Sbjct: 1093 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1152
Query: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQN-------L 658
+ E + + E ++++ L Q ++ + L++ ++R +++ L
Sbjct: 1153 HGERDVEVERWRERVAQLLERWQAVLAQ---TDVRQRELEQLGRQLRYYRESADPLGAWL 1209
Query: 659 SELEQLNENLKKVAF-DVKMENEKL----VLACEDVRH--QLEECLAGNNQLSLEKNTIV 711
+ + E ++ + D + E+L L E RH ++EEC Q
Sbjct: 1210 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1269
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
L K ++E AKK ++ + E I+E + R + L ++ IK +
Sbjct: 1270 LQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQY-IKFISET 1326
Query: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK-LKERSSKLQEE 830
+ E ++ EQ + +E + ++LE+Q+QL + + + E+ KE ++QEE
Sbjct: 1327 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1386
Query: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ----EELERLR---EEQSRTAPVA 883
+ + +A + +++I+E+ + L E + E ER R EE+ R +
Sbjct: 1387 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1446
Query: 884 DPKT-------LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL--- 933
T + L + + K +EE + ++ ++D++Q K Q L
Sbjct: 1447 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506
Query: 934 -----------QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK-SLQKTIEQIKTQLHE 981
Q + ++E R Q E+ Q +E+ +++ +L+ + +L
Sbjct: 1507 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1566
Query: 982 ERQDIQTDNSDI---FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELE------- 1031
+R + + QE V + +E+ +AE ER + ERELE
Sbjct: 1567 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER-AREEAERELERWQLKAN 1625
Query: 1032 --IKL-LNEKNISLTKQIDQL----SKDEV-------GKL-TQIIQQKDLEIQALHARIS 1076
++L L + ++ K + Q K+E GK Q ++Q++L Q L +
Sbjct: 1626 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1685
Query: 1077 STSHT--------QDVVYL-------QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 1121
T Q+++ L +QQ Q E ++ T++ L+ E K
Sbjct: 1686 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1745
Query: 1122 ----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI-------IREKD 1170
M ++A+K A + + ++K R E+ FRE + +R+ R++
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAEEAARLRALAEEAKRQRQ 1804
Query: 1171 I-EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM--EEWKQQ 1227
+ E DA Q+ + + + + EA + + + E L+E++ ++++++ +E Q+
Sbjct: 1805 LAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDEAFQR 1863
Query: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Q QH+ A ++E L QL+ + + L D + E+ LK ++
Sbjct: 1864 RRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1922
Query: 1288 L----AQVQHSIGQL-CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
A+++ +G++ N +D L K +L +A + E R ++E + S
Sbjct: 1923 AAAGKAELELELGRIRSNAEDTLRSK---EQAELEAARQRQLAAEEERRRREAEERVQKS 1979
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS---------------ELERKE 1387
++E RK+ E+ ++ E RL + S + E K
Sbjct: 1980 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2039
Query: 1388 H----EQTDSEIKQ-LKEKQDVLQKLLKEKDLLIKAKSD------QLLSSNENFTNKVNE 1436
H +Q + E++Q L+++Q VL +L E + +A + Q +V E
Sbjct: 2040 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2099
Query: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
E L+Q+ + + KL+ E E+ E R + E AL++ + M + K
Sbjct: 2100 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHK 2157
Query: 1497 EFECHSMKEKALAFEQL--LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV--MLA 1552
+F ++++KA ++L L+ + + + N L ++ ++ + ++R QV L
Sbjct: 2158 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2217
Query: 1553 LKQKQMENTA-------LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED- 1604
+ QME + +N LRDK+ + + L+ + + + R ++AA++
Sbjct: 2218 SVRVQMEELSKLKARIEAENRALILRDKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2276
Query: 1605 ------REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
E L ++ + E+ L A++ A+ + + E LQ+Q + +Q A +
Sbjct: 2277 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQEQ----ARR 2331
Query: 1659 LSVSQEQV-KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW-------KKNAE 1710
L +EQ+ +Q A Q LE +Q + M SAE E+ K +AE +++A+
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQ 2390
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ-----------IEELKRQNE---- 1755
+ + E L A L + L+++ +Q I EL+R+ E
Sbjct: 2391 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2450
Query: 1756 ------LRQEMLDDVQKKLM-----SLANSSEGKVDKVLMRNLFI 1789
L+ E + VQ++ + +L S + D +L R FI
Sbjct: 2451 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2495
Score = 119 bits (298), Expect = 3e-26
Identities = 237/1253 (18%), Positives = 497/1253 (39%), Gaps = 200/1253 (15%)
Query: 586 ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
+ L+ L + + Q+ ELK+ Q E +R + L L+++ + +
Sbjct: 952 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1011
Query: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL------ACEDVRHQLEECLAG 699
+++A+ +E+E L + + +++ E EK++ A +R +LE L
Sbjct: 1012 QQKAQ--------AEVEGLGKGVARLS----AEAEKVLALPEPSPAAPTLRSELELTLGK 1059
Query: 700 NNQLSLEKNTIVETLKMEKGEIEA-----ELCWAKKRLLEEANKYEKTIEELSNARNLNT 754
Q+ +E LK I E+ A + L+EA T+ EL +
Sbjct: 1060 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK---- 1115
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ +L+ E +D L + E ++L Q +++
Sbjct: 1116 ------------------ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1157
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE--RL 872
+ +E+ +ER ++L L+++ L + ++ ++ +E+ R L +E + L L+ R
Sbjct: 1158 VEVERWRERVAQL---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1214
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
R+EQ + P+AD + + QL + LEE +H +K+ E Q +K Q + +
Sbjct: 1215 RQEQIQAMPLADSQAVRE---------QLRQEQALLEEIERHGEKVEECQRFAK-QYINA 1264
Query: 933 LQEQKKEMDEFRYQHE-----------------------QMNATHTQLFLEKDEEIKSLQ 969
+++ + ++ ++ Q E + +++L + IK +
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1324
Query: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
+T+ +++ + Q + + + E + +E H +KA+ ER K +++R
Sbjct: 1325 ETLRRMEEEERLAEQQ-RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1383
Query: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
E +++ + ++ Q + S E +L Q+ Q + EIQA + + ++ + +++
Sbjct: 1384 QE-EVVRREEAAVDAQQQKRSIQE--ELQQLRQSSEAEIQAKARQAEAAERSR--LRIEE 1438
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+++ ++ E R+ + E + EA + Q+E ++L + +
Sbjct: 1439 EIRVVRLQLEAT-------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1491
Query: 1150 SGQDMFRETIQNLSRI------IREKDIEIDALSQ------------------KCQTLLA 1185
Q + ++ SR+ REK + AL + + + +
Sbjct: 1492 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1551
Query: 1186 VLQTSSTGNEAG--------GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
L+T+ EA + Q E LQE Q+++ E + Q + +
Sbjct: 1552 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1611
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
E A+ + E QL+A + +LQ + +S Q E + ++ + + +
Sbjct: 1612 E-AERELERWQLKANEAL----RLRLQAEEVAQQKSLAQAEAE-----KQKEEAEREARR 1661
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
++ + + ++ +L L +A+ A+ +QEL LR +
Sbjct: 1662 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA------------EQELIRLRAETE 1709
Query: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL---QKLLKEKDL 1414
+ + + L+E RL AA ++ + ++ ++E+ +++ + +VL + +E+
Sbjct: 1710 QGEQQRQLLEEELARLQREAAAATQ----KRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Query: 1415 LIKAKSDQLLSSNEN-FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIV---- 1469
KS Q L + F E LR K + + E D + + E E+++
Sbjct: 1766 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1825
Query: 1470 ----ETYRGKETEYQALQET---NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
E R K AL+E N + + ++ F+ ++E+A + ++E+
Sbjct: 1826 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1885
Query: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
+ L K + E T+ +++ ++ +LALK + A + E++ L RSN E
Sbjct: 1886 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE-LELGRIRSNAEDT 1944
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
E E + R+ A E+R + EE++ S A E A+ Q +E ++
Sbjct: 1945 LRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQRKAALEEVE 1998
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
+ +K + L+ QE +Q L A+ QK+L
Sbjct: 1999 R---LKAKVEEARRLRERAEQESARQLQL---------------------AQEAAQKRLQ 2034
Query: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNE 1755
AE K +A ++ K LQ+ L + + LD E E+ EE + Q E
Sbjct: 2035 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2087
Score = 92.8 bits (229), Expect = 3e-18
Identities = 131/757 (17%), Positives = 311/757 (41%), Gaps = 65/757 (8%)
Query: 41 GTEEVEAELPDSRTKEIEAIHAILRSENE--RLKKLCTDLEEKHEASEIQIKQQSTSYRN 98
G E+E EL R+ + + + ++E E R ++L + E + +E ++++ +
Sbjct: 1926 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1985
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+Q++ + ++ + +++ + A Q + A H A
Sbjct: 1986 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2045
Query: 159 DDDMDFGDIISSQQEI-NRLSNEVS---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+ + + +Q + ++L E R E R A+ AQ +++E
Sbjct: 2046 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE---- 2101
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
LKQ+ ++ + + ++ E +RR + E + ++ + + +
Sbjct: 2102 -----RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEME 2154
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
E L + ++++ + L+++ E+ + L+++++ + + + A R +
Sbjct: 2155 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2214
Query: 335 EQEQLNVEKRQIME-----ECENLKLECSK-------LQPSAVKQSDTMTEKERILAQSA 382
E + V+ ++ + E EN L LQ A K E R+ S
Sbjct: 2215 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL---SV 2271
Query: 383 SVEEVFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL------- 433
+ +E RL+Q + A+ + L + ++ +LK E+L+++K L
Sbjct: 2272 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2331
Query: 434 LSQEKEELQMSLLKLNNEYE-VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
L ++KE++ L + ++ +++ R + + +E RL L E Q+ +E++
Sbjct: 2332 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE--RLKLRVAEMSRAQARAEEDA 2389
Query: 493 L-----IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---DLNDEKKRVH 544
EI E + + AT+ + + L Q+ + D +L++ +L EK+++
Sbjct: 2390 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2449
Query: 545 QLEDDKMDITKE--LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSI 602
Q E + + E VQ+E+L+Q AL L+++ + E ++Q E
Sbjct: 2450 Q-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2508
Query: 603 QKENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+ + L+E ++ ++++ + R L+ S+ + ++ EAE +++ EL
Sbjct: 2509 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR--------RQHEAE-EGVRRKQEEL 2559
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
+QL + ++ + EN++L + + Q LA + +++ + +TL + +
Sbjct: 2560 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2619
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+ A+ + + + + + L A L+ LQ
Sbjct: 2620 DGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2656
Score = 83.2 bits (204), Expect = 2e-15
Identities = 194/1114 (17%), Positives = 417/1114 (37%), Gaps = 196/1114 (17%)
Query: 734 EEANKYEKTIEELSNARNLNTSALQLEHEHLIKL----------------NQKKDMEIAE 777
+E ++ ++ I EL + R L A + H ++L QK E+
Sbjct: 963 QEESRCQRCISELKDIR-LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1021
Query: 778 LKKNIEQMDTDHKET---------KDVLSSSLE-EQKQLTQLINKKEIFIEKLKERSSKL 827
L K + ++ + ++ L S LE +L Q+ + I++EKLK S +
Sbjct: 1022 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1081
Query: 828 ------QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
+E L + + L++ + + T+ E + + S+K +LR + P
Sbjct: 1082 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-----------KLRAQAEAQQP 1130
Query: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
D L E+ + E L++ +E + QLL+ Q + D
Sbjct: 1131 TFDA--------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1182
Query: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE-ERQDIQTDNSDIFQETKVQ 1000
+ + EQ+ + + E + + + + + + Q+ D Q + QE +
Sbjct: 1183 VRQRELEQLGR-QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1241
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
IE EK + + ++ + IK+ EL++ + L K +V ++
Sbjct: 1242 E-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1297
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
+ Q+ ++++ ++ +++ + +Q + ++ + L+ E E+ + ++
Sbjct: 1298 VIQEYVDLRTHYSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1356
Query: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
K + A A + + E K+L R + ++R ++ +DA
Sbjct: 1357 KQRQLAEAHAQAKAQAEREAKELQQRMQEE--------------VVRREEAAVDA----- 1397
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+QQ + ++E QQ+ Q A
Sbjct: 1398 ----------------------------------QQQKRSIQEELQQLR------QSSEA 1417
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
++Q + Q +A S+L+++ + + T+ + G E
Sbjct: 1418 EIQAKARQAEAA------ERSRLRIEEEIRVVRLQLEATERQRGGAE------------- 1458
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
G+L + + A Q+ E + +V ES Q E+E + E +
Sbjct: 1459 ------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1512
Query: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
A +E L + E E +E+++ ++ Q L+ + + +++K
Sbjct: 1513 AA----REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1568
Query: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
+ E + AV L+E + + ++ E R +E +
Sbjct: 1569 ASFAEKTAQLERSLQEEHV---AVAQLRE----------EAERRAQQQAEAERAREEAER 1615
Query: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
L+ +K + LR + ++K+LA + K+KE+ + + ++++++ +
Sbjct: 1616 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1675
Query: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Q+ Q LA Q + A + E+ RLR + + Q+ + L L + REA
Sbjct: 1676 AEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ----REAA 1730
Query: 1601 AA----EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
AA ++ EA+L K +E L S + A E + + + L+ + + +E A
Sbjct: 1731 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1790
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK--QKQLIAEWKKNAENLEG 1714
++++E +Q L+ +E+ A AE E+ ++L A + E
Sbjct: 1791 RLRALAEEAKRQRQLA------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1838
Query: 1715 KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
++ L E A + RL E + ++EE Q++ D++++L L +
Sbjct: 1839 EI-----ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA------DIEERLAQLRKA 1887
Query: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGS 1808
S+ ++++ + L + E+L L S
Sbjct: 1888 SDSELER--QKGLVEDTLRQRRQVEEEILALKAS 1919
Score = 70.1 bits (170), Expect = 2e-11
Identities = 268/1447 (18%), Positives = 557/1447 (38%), Gaps = 159/1447 (10%)
Query: 474 LNLEAKEQELNQSISEKET-LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
L++E + +L+ +I E+E L +E E L+ + TK + + +Q N+ D+++
Sbjct: 350 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTK-LQMEAGLCEEQLNQADALLQSD 408
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ L K + ++ ++LD + + +I+ + ND+ K + E + ++
Sbjct: 409 VRLLAAGK-----VPQRAGEVERDLD-KADSMIR--LLFNDVQTLKDGRHPQGEQMYRRV 460
Query: 593 NKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLK---- 645
+ E V+I+ E NL LK + +++++ + +Q + DS + LL
Sbjct: 461 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEE 520
Query: 646 --------EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
E ++ +++ L L++++++ ++ R +CL
Sbjct: 521 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL 580
Query: 698 AGNNQLSLEKNTIVETLKMEKGEIEAE---LCWAKKRLLEEANKYEKTIEELSNARNLNT 754
+L L+ ++ + K +E+ + A K L+ K E+ + + RN N
Sbjct: 581 G---RLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNM 637
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQM-DTDHKETKDVLSSSLEEQKQLTQLINKK 813
+A + + L++ + K+ +I EL+ +++ DH V S Q Q + ++
Sbjct: 638 TAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLC 697
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
LKE ++ Q D ++E LQ+ E LR
Sbjct: 698 CCIEAHLKENAAYFQFFSD-------------------------VREAEGQLQKLQEALR 732
Query: 874 EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE-------DQNQSK 926
+ S + D + + E QLN K HL K + +++ + +
Sbjct: 733 RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 792
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQM------------------NATHTQLFL------EKD 962
+ LL ++ E+ + Q+ A + FL E
Sbjct: 793 LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 852
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
E + L+ + + T H+ D+++ + VQ + + + L K E +R
Sbjct: 853 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTL-KPEEQRQA 911
Query: 1023 KGIKERELEIKLLNEKNISLTKQIDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHT 1081
E + L + ++ D+L ++ E G + QQ +Q+L S
Sbjct: 912 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRC 968
Query: 1082 QDVV--YLQQQLQAYAMEREKVFAVL----NEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Q + +LQ A E V + E RE + E K V + +
Sbjct: 969 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1028
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS----QKCQTLLAVLQTSS 1191
L E +K+ E S T+++ + K ++ +LS +K +T+ V++ +
Sbjct: 1029 LSAEAEKVLALPEPSPA---APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1085
Query: 1192 TGNEAGGVNSNQFEE------LLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
E + Q +E L E + K +KK+ + T ++ E QE
Sbjct: 1086 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1145
Query: 1246 LHQLQ-------AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
+LQ +V + ++L + ++ + + +L+ G++L + S L
Sbjct: 1146 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1205
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSA-ECLRASKSEVLSESSELLQQELEELRKSLQ 1357
L Q+ + L Q+ E LR + + L E E +++EE ++ +
Sbjct: 1206 ----GAWLQDARRRQEQIQAMPLADSQAVREQLR--QEQALLEEIERHGEKVEECQRFAK 1259
Query: 1358 EKDATIR--TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+ I+ LQ ++ A+ + K ++S I++ + + +L
Sbjct: 1260 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1319
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
IK S+ L E E L Q +ER+ +E + K + E +
Sbjct: 1320 IKFISETLRRMEE-------EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1372
Query: 1476 ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
E E + LQ+ + ++R +E + ++K + ++ L++ Q E+ ++
Sbjct: 1373 EREAKELQQRMQE--EVVRREEAAVDAQQQKR-SIQEELQQLRQSSEAEIQAKARQAEAA 1429
Query: 1536 QEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRNHL 1588
+ + ++E V L L+ + + + E+Q LR + + ++ +E ERLR +
Sbjct: 1430 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1489
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
+D R+ A + ++++ + EK + A+E QA + E Q V
Sbjct: 1490 ---QDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQAE-EAERRLRQAEVE 1544
Query: 1649 SKQRDETALQLS--VSQEQVKQYALSLANLQMVLEHFQQEEK---AMYSAELEKQKQLIA 1703
++ + AL+ + ++ +++ S A LE QEE A E E++ Q A
Sbjct: 1545 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1604
Query: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
E ++ E E ++ Q +EA A + +Q + + + E+ K + E
Sbjct: 1605 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1664
Query: 1764 VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHD 1823
+++ + +E +++K R L G E++RL + E+ QL +
Sbjct: 1665 AEEQAVRQRELAEQELEK--QRQLAEGTAQQRLAAEQELIRLRAET--EQGEQQRQLLEE 1720
Query: 1824 DQGGVTR 1830
+ + R
Sbjct: 1721 ELARLQR 1727
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 178 bits (452), Expect = 4e-44
Identities = 346/1697 (20%), Positives = 687/1697 (40%), Gaps = 229/1697 (13%)
Query: 170 SQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQS-------EICKLQNIIKELK 222
+Q E+ L V+RL +E + + S A T S+ ++ L I E
Sbjct: 1056 AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKL 1115
Query: 223 QNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIET 282
+ S I Q VL+ AH+++L E ++ L + E L+ L Q +
Sbjct: 1116 KTISLVIRGTQGAEEVLR-AHEEQLKE-AQAVPATLPELEATKASLKKLRAQAEAQQPTF 1173
Query: 283 DL--SKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLN 340
D ++ Q+ + LQ E ++E+ +++ + ++ + D+ +RE EQL
Sbjct: 1174 DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLG 1233
Query: 341 VEKRQIMEECENL-----KLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALS 395
+ R E + L + Q A+ +D+ +E++ + A +EE+ R + +
Sbjct: 1234 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVE 1293
Query: 396 DAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI 455
+ + + + +D L K ++ +K + E + + L Y +
Sbjct: 1294 ECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL 1353
Query: 456 KSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEE-LDRQNQEATKHMILI 514
+ ++ I SE LR +E +E+ Q +E+ +AE+E L++Q Q A H
Sbjct: 1354 TTLTSQYIKFISET--LR-RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA--- 1407
Query: 515 KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL 574
+K Q E ++ +L+Q + +E R + D Q+++ IQ E L
Sbjct: 1408 ---QAKAQAEREA--KELQQRMQEEVVRREEAAVDAQ--------QQKRSIQEE-----L 1449
Query: 575 HLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD 634
+Q E +++ Q ++ S + I++E ++ + E + EL +
Sbjct: 1450 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1509
Query: 635 SNSNFKDTLLKEREAEVRNLKQNLSELEQLNE----NLKKVAFDVKMENEKLVLACEDVR 690
+ + +E +R Q+ S+ ++ E + K + E ++ + A E++R
Sbjct: 1510 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1569
Query: 691 HQLEECLAGNNQLSLEKNTIVET-LKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA 749
Q EE Q +E+ V+ L+ + EAEL + E+ + E++++E
Sbjct: 1570 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEE--- 1626
Query: 750 RNLNTSALQLEHEHLIKLNQKKDMEIA--ELKKNIE--QMDTDHKETKDVLSSSLEEQKQ 805
+ + QL E + Q+ + E A E ++ +E Q+ + + + + +QK
Sbjct: 1627 ---HVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1683
Query: 806 LTQL-INKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
L Q K++ E+ R K +E QA+R+ E+ Q +E++ + ++
Sbjct: 1684 LAQAEAEKQKEEAEREARRRGKAEE------QAVRQRELAEQELEKQRQLAEGTAQQRLA 1737
Query: 865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQ 924
++EL RLR E TE + QL LEEE+ Q+ Q
Sbjct: 1738 AEQELIRLRAE----------------TEQGEQQRQL------LEEELARLQREAAAATQ 1775
Query: 925 SKMQLLQSLQEQKKEMD-----EFRYQHEQMNATHTQL---------FLEKDEEIKSLQK 970
+ +L L + + EM+ + R + E + + F E EE L+
Sbjct: 1776 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRA 1835
Query: 971 TIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL 1030
E+ K Q +D Q + + + E + + ++ +TE + +KE+E
Sbjct: 1836 LAEEAKRQRQLAEEDAAR------QRAEAERVLAEKLAAIGEATRLKTEAEI-ALKEKEA 1888
Query: 1031 EIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQ 1090
E +++ +L++DE Q++ LE QA H D+ Q
Sbjct: 1889 E-----------NERLRRLAEDEA------FQRRRLEEQA-------AQHKADIEERLAQ 1924
Query: 1091 LQ-AYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
L+ A E E+ ++ + R+ ++ E ++ + A+ E A + +L R S
Sbjct: 1925 LRKASDSELERQKGLVEDTLRQRRQVEEE---ILALKASFEKAAAGKAELELELG-RIRS 1980
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
+ +D R Q R++ + + ++ + V ++ + EA + Q + L+
Sbjct: 1981 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA----ARQRKAALE 2036
Query: 1210 ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTG 1269
E ++LK +V++ +++ QE QLQ L +LQ +
Sbjct: 2037 EVERLKAKVEEARRLRERAE-------------QESARQLQ---LAQEAAQKRLQAEEKA 2080
Query: 1270 LIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLD------IISPQLSSASLLT 1323
+ +Q E +L+ Q L Q Q + QL + + + + + ++ S
Sbjct: 2081 HAFAVQQKEQELQ---QTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2137
Query: 1324 PQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSEL 1383
+ AE L+ S E ++ Q E+LRK +++ A R Q L AA +E+
Sbjct: 2138 VEEAERLKQSAEEQAQARAQA-QAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAADAEM 2194
Query: 1384 ER--KEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLR 1441
E+ K EQT + Q++++ L+ L+E D ++L T + +
Sbjct: 2195 EKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVE 2254
Query: 1442 QAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLRE------ 1495
+ + +++ ++ L +++ EN ++ R K+ + LQE K + E
Sbjct: 2255 EELFSVRVQMEELSKLKARIEAENRALI--LRDKDNTQRFLQEEAEKMKQVAEEAARLSV 2312
Query: 1496 --------KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQER- 1546
++ + ++ E++LKEK Q A Q+K + +Q R
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 1547 ---DQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAE 1603
D+ +A +Q E Q ++ R ++ + E ERL+ + E + R AE
Sbjct: 2373 LQEDKEQMA-QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQAR----AE 2427
Query: 1604 DREAKLRKKVTVLEEKL----------VSSSNAMENASHQASVQVESLQEQLNVVSKQRD 1653
+ + RK+ + EKL V+ +E Q+ E L+E + + ++++
Sbjct: 2428 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2487
Query: 1654 ETA-----LQL------SVSQEQV-------KQYALSLANLQMVLEHFQQEEKA----MY 1691
+ LQL +V QEQ+ +Q LS + + E F ++EKA ++
Sbjct: 2488 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2547
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELK 1751
E+ K +QL E ++ + +E + L ++EA A + + +Q+E+ +
Sbjct: 2548 QDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQR 2607
Query: 1752 RQNELRQEMLDDVQKKL 1768
RQ E E+L + ++L
Sbjct: 2608 RQQE---ELLAEENQRL 2621
Score = 159 bits (402), Expect = 3e-38
Identities = 292/1451 (20%), Positives = 593/1451 (40%), Gaps = 171/1451 (11%)
Query: 24 ASLTGQISNFTKDMLMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHE 83
A L S K + G+E V E D RT E L + + K ++ + E
Sbjct: 1318 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSE-----LTTLTSQYIKFISETLRRME 1372
Query: 84 ASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTAS 143
E +QQ R +L EVE + K RQ+A K Q+ ++ +
Sbjct: 1373 EEERLAEQQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1430
Query: 144 SSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRL----ESEVGHWRHIAQTSK 199
A + +QQ+ + E+ +L E+E+ A+ ++
Sbjct: 1431 REEA-------------------AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAE 1471
Query: 200 AQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELS 259
++ + +LQ E ++ ++ + A +++ E + R R ++
Sbjct: 1472 RSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ 1531
Query: 260 DYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ---IEKVESTKKMEQLE-DKI 315
D +R + E L + ++ + E Q+ +Q L+ ++ E+ +++ Q E ++
Sbjct: 1532 DESQRKRQAEVEL----ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERA 1587
Query: 316 KDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKE 375
+ + L +A+ R + +L ++ E+ L+ LQ V + E E
Sbjct: 1588 RQVQVALETAQ------RSAEAELQSKRASFAEKTAQLE---RSLQEEHVAVAQLREEAE 1638
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R Q A E +A +AE E+ R A + L+L+++ E + ++KSL
Sbjct: 1639 RRAQQQAEAE------RAREEAERELERWQLK------ANEALRLRLQAEEVAQQKSLAQ 1686
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISL-DSELHDLRLNLEAKEQELNQSISEKETLI 494
E E+ + + + A R L + EL R E Q+ + E L
Sbjct: 1687 AEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1746
Query: 495 AEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDIT 554
AE E+ ++Q Q L++++L++ Q E + K +Q+L E +V
Sbjct: 1747 AETEQGEQQRQ-------LLEEELARLQREAAAATQK-RQELEAELAKVR---------- 1788
Query: 555 KELDVQKEKLIQSEV-ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHI 613
+ E L+ S+ A + T +K + ++E + + E ++ E K
Sbjct: 1789 ----AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1844
Query: 614 RQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAF 673
+ EE+ +R R E + L + + + T LK EAE+ LK+ +E NE L+++A
Sbjct: 1845 QLAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIA-LKEKEAE----NERLRRLAE 1898
Query: 674 DVKMENEKLVLACEDVRHQLEECL-----AGNNQLSLEKNTIVETLKMEKGEIEAELCWA 728
D + +L + +EE L A +++L +K + +TL+ ++ ++E E+ A
Sbjct: 1899 DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR-QRRQVEEEIL-A 1956
Query: 729 KKRLLEEANKYEKTIE-ELSNARNLNTSAL------QLEHEHLIKLNQKKDMEIAELKKN 781
K E+A + +E EL R+ L +LE +L +++ E ++
Sbjct: 1957 LKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2016
Query: 782 IEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSK----LQEELDKYSQA 837
+++ +E ++LEE ++L + + E+ ++ S++ QE K QA
Sbjct: 2017 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2076
Query: 838 LRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASE 897
K +++K++ L ++ + ++L E R A A+ + + E A
Sbjct: 2077 EEKAHAF--AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2134
Query: 898 VSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Q+ EE + ++ E+Q Q++ Q + ++ +KE ++ + Q +
Sbjct: 2135 RRQV--------EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQ 2186
Query: 958 FLEKDEEIKSLQKTIEQIKTQLHEERQDI--------QTDNSDIFQETKVQSLNIENGSE 1009
D E++ +K EQ Q + Q++ +TD+ + ++Q L E
Sbjct: 2187 KQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEA 2246
Query: 1010 KHDLSKAETERLVKGIKERE---LEIKLLNEKNISLTKQIDQLSK---DEVGKLTQIIQQ 1063
S+ E E ++ E L+ ++ E + + D + +E K+ Q+ ++
Sbjct: 2247 ARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEE 2306
Query: 1064 -KDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM 1122
L + A A +D+ QQ+ A M +EK+ AV +E + LK E +
Sbjct: 2307 AARLSVAAQEAARLRQLAEEDLA--QQRALAEKMLKEKMQAV-----QEATRLKAEAELL 2359
Query: 1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--IQNLSRIIREKDIEIDALSQKC 1180
KE A Q++ ++L E Q + ET Q R++ +E+ A +++
Sbjct: 2360 QQ---QKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERL 2412
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+ +A + + E + ++ +++ +++ + E Q+ +T VQ ++ +
Sbjct: 2413 KLRVAEMSRAQARAE------EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQ 2466
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGL-IQSYEQNETKLKNFGQELAQVQHSIGQLC 1299
Q + +L+ + KLQ + L ++S E + + QE +Q S
Sbjct: 2467 QSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS---FL 2523
Query: 1300 NTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRK----S 1355
+ KD LL + I + + L +K++ L E + QQ++E+ R+ S
Sbjct: 2524 SEKDSLLQRERFIEQEKAKLEQLFQD-----EVAKAQQLREEQQRQQQQMEQERQRLVAS 2578
Query: 1356 LQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
++E +E R + + + R++ E E ++L+E+ +LL+E+
Sbjct: 2579 MEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQ----LQLLEEQHRA 2634
Query: 1416 IKAKSDQLLSS 1426
A S+++ +S
Sbjct: 2635 ALAHSEEVTAS 2645
Score = 128 bits (322), Expect = 5e-29
Identities = 319/1545 (20%), Positives = 631/1545 (40%), Gaps = 244/1545 (15%)
Query: 467 SELHDLRLNLEAKE----------------QELNQSISEKETLIAEIEELD----RQNQE 506
SEL D+RL LEA E +E Q I+E++ AE+E L R + E
Sbjct: 1014 SELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAE 1073
Query: 507 ATKHMILIKDQLSKQ--QNEGDSIISKLKQDLN------DEKKRVHQLEDDKMDITKELD 558
A K + L + + ++E + + KL+Q + ++ K + + + L
Sbjct: 1074 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLR 1133
Query: 559 VQKEKLIQSE---VALNDLHLTKQKL----------EDKVENLVDQLNKSQESNVSIQKE 605
+E+L +++ L +L TK L + + L D+L +QE +Q+
Sbjct: 1134 AHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1193
Query: 606 NLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQN-------L 658
+ E + + E ++++ L Q ++ + L++ ++R +++ L
Sbjct: 1194 HGERDVEVERWRERVAQLLERWQAVLAQ---TDVRQRELEQLGRQLRYYRESADPLGAWL 1250
Query: 659 SELEQLNENLKKVAF-DVKMENEKL----VLACEDVRH--QLEECLAGNNQLSLEKNTIV 711
+ + E ++ + D + E+L L E RH ++EEC Q
Sbjct: 1251 QDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYE 1310
Query: 712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
L K ++E AKK ++ + E I+E + R + L ++ IK +
Sbjct: 1311 LQLVTYKAQLEPVASPAKKPKVQSGS--ESVIQEYVDLRTHYSELTTLTSQY-IKFISET 1367
Query: 772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEK-LKERSSKLQEE 830
+ E ++ EQ + +E + ++LE+Q+QL + + + E+ KE ++QEE
Sbjct: 1368 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEE 1427
Query: 831 LDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ----EELERLR---EEQSRTAPVA 883
+ + +A + +++I+E+ + L E + E ER R EE+ R +
Sbjct: 1428 VVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQ 1487
Query: 884 DPKT-------LDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSL--- 933
T + L + + K +EE + ++ ++D++Q K Q L
Sbjct: 1488 LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547
Query: 934 -----------QEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIK-SLQKTIEQIKTQLHE 981
Q + ++E R Q E+ Q +E+ +++ +L+ + +L
Sbjct: 1548 VKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1607
Query: 982 ERQDIQTDNSDI---FQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELE------- 1031
+R + + QE V + +E+ +AE ER + ERELE
Sbjct: 1608 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAER-AREEAERELERWQLKAN 1666
Query: 1032 --IKL-LNEKNISLTKQIDQL----SKDEV-------GKL-TQIIQQKDLEIQALHARIS 1076
++L L + ++ K + Q K+E GK Q ++Q++L Q L +
Sbjct: 1667 EALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1726
Query: 1077 STSHT--------QDVVYL-------QQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHK 1121
T Q+++ L +QQ Q E ++ T++ L+ E K
Sbjct: 1727 LAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAK 1786
Query: 1122 ----MMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRI-------IREKD 1170
M ++A+K A + + ++K R E+ FRE + +R+ R++
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAEEAARLRALAEEAKRQRQ 1845
Query: 1171 I-EIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKM--EEWKQQ 1227
+ E DA Q+ + + + + EA + + + E L+E++ ++++++ +E Q+
Sbjct: 1846 LAEEDAARQRAEAERVLAEKLAAIGEATRLKT-EAEIALKEKEAENERLRRLAEDEAFQR 1904
Query: 1228 VMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQE 1287
Q QH+ A ++E L QL+ + + L D + E+ LK ++
Sbjct: 1905 RRLEEQAAQHK-ADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1963
Query: 1288 L----AQVQHSIGQL-CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESS 1342
A+++ +G++ N +D L K +L +A + E R ++E + S
Sbjct: 1964 AAAGKAELELELGRIRSNAEDTLRSK---EQAELEAARQRQLAAEEERRRREAEERVQKS 2020
Query: 1343 ELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATS---------------ELERKE 1387
++E RK+ E+ ++ E RL + S + E K
Sbjct: 2021 LAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2080
Query: 1388 H----EQTDSEIKQ-LKEKQDVLQKLLKEKDLLIKAKSD------QLLSSNENFTNKVNE 1436
H +Q + E++Q L+++Q VL +L E + +A + Q +V E
Sbjct: 2081 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEE 2140
Query: 1437 NELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREK 1496
E L+Q+ + + KL+ E E+ E R + E AL++ + M + K
Sbjct: 2141 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQ--EAARRAQAEQAALRQKQAADAEMEKHK 2198
Query: 1497 EFECHSMKEKALAFEQL--LKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQV--MLA 1552
+F ++++KA ++L L+ + + + N L ++ ++ + ++R QV L
Sbjct: 2199 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELF 2258
Query: 1553 LKQKQMENTA-------LQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAED- 1604
+ QME + +N LRDK+ + + L+ + + + R ++AA++
Sbjct: 2259 SVRVQMEELSKLKARIEAENRALILRDKD-NTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2317
Query: 1605 ------REAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQ 1658
E L ++ + E+ L A++ A+ + + E LQ+Q + +Q A +
Sbjct: 2318 ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQEQ----ARR 2372
Query: 1659 LSVSQEQV-KQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEW-------KKNAE 1710
L +EQ+ +Q A Q LE +Q + M SAE E+ K +AE +++A+
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM-SAEAERLKLRVAEMSRAQARAEEDAQ 2431
Query: 1711 NLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ-----------IEELKRQNE---- 1755
+ + E L A L + L+++ +Q I EL+R+ E
Sbjct: 2432 RFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2491
Query: 1756 ------LRQEMLDDVQKKLM-----SLANSSEGKVDKVLMRNLFI 1789
L+ E + VQ++ + +L S + D +L R FI
Sbjct: 2492 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFI 2536
Score = 119 bits (298), Expect = 3e-26
Identities = 237/1253 (18%), Positives = 497/1253 (39%), Gaps = 200/1253 (15%)
Query: 586 ENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLK 645
+ L+ L + + Q+ ELK+ Q E +R + L L+++ + +
Sbjct: 993 QQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1052
Query: 646 EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVL------ACEDVRHQLEECLAG 699
+++A+ +E+E L + + +++ E EK++ A +R +LE L
Sbjct: 1053 QQKAQ--------AEVEGLGKGVARLS----AEAEKVLALPEPSPAAPTLRSELELTLGK 1100
Query: 700 NNQLSLEKNTIVETLKMEKGEIEA-----ELCWAKKRLLEEANKYEKTIEELSNARNLNT 754
Q+ +E LK I E+ A + L+EA T+ EL +
Sbjct: 1101 LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK---- 1156
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKE 814
+ +L+ E +D L + E ++L Q +++
Sbjct: 1157 ------------------ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1198
Query: 815 IFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELE--RL 872
+ +E+ +ER ++L L+++ L + ++ ++ +E+ R L +E + L L+ R
Sbjct: 1199 VEVERWRERVAQL---LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARR 1255
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
R+EQ + P+AD + + QL + LEE +H +K+ E Q +K Q + +
Sbjct: 1256 RQEQIQAMPLADSQAVRE---------QLRQEQALLEEIERHGEKVEECQRFAK-QYINA 1305
Query: 933 LQEQKKEMDEFRYQHE-----------------------QMNATHTQLFLEKDEEIKSLQ 969
+++ + ++ ++ Q E + +++L + IK +
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1365
Query: 970 KTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERE 1029
+T+ +++ + Q + + + E + +E H +KA+ ER K +++R
Sbjct: 1366 ETLRRMEEEERLAEQQ-RAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM 1424
Query: 1030 LEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQ 1089
E +++ + ++ Q + S E +L Q+ Q + EIQA + + ++ + +++
Sbjct: 1425 QE-EVVRREEAAVDAQQQKRSIQE--ELQQLRQSSEAEIQAKARQAEAAERSR--LRIEE 1479
Query: 1090 QLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+++ ++ E R+ + E + EA + Q+E ++L + +
Sbjct: 1480 EIRVVRLQLEAT-------ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQD 1532
Query: 1150 SGQDMFRETIQNLSRI------IREKDIEIDALSQ------------------KCQTLLA 1185
Q + ++ SR+ REK + AL + + + +
Sbjct: 1533 ESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQV 1592
Query: 1186 VLQTSSTGNEAG--------GVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQH 1237
L+T+ EA + Q E LQE Q+++ E + Q + +
Sbjct: 1593 ALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERARE 1652
Query: 1238 ESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQ 1297
E A+ + E QL+A + +LQ + +S Q E + ++ + + +
Sbjct: 1653 E-AERELERWQLKANEAL----RLRLQAEEVAQQKSLAQAEAE-----KQKEEAEREARR 1702
Query: 1298 LCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
++ + + ++ +L L +A+ A+ +QEL LR +
Sbjct: 1703 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA------------EQELIRLRAETE 1750
Query: 1358 EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVL---QKLLKEKDL 1414
+ + + L+E RL AA ++ + ++ ++E+ +++ + +VL + +E+
Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQ----KRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Query: 1415 LIKAKSDQLLSSNEN-FTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIV---- 1469
KS Q L + F E LR K + + E D + + E E+++
Sbjct: 1807 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1866
Query: 1470 ----ETYRGKETEYQALQET---NMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
E R K AL+E N + + ++ F+ ++E+A + ++E+
Sbjct: 1867 AAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLR 1926
Query: 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
+ L K + E T+ +++ ++ +LALK + A + E++ L RSN E
Sbjct: 1927 KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELE-LELGRIRSNAEDT 1985
Query: 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQ 1642
E E + R+ A E+R + EE++ S A E A+ Q +E ++
Sbjct: 1986 LRSKEQAELEAARQRQLAAEEERRRR------EAEERVQKSLAAEEEAARQRKAALEEVE 2039
Query: 1643 EQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLI 1702
+ +K + L+ QE +Q L A+ QK+L
Sbjct: 2040 R---LKAKVEEARRLRERAEQESARQLQL---------------------AQEAAQKRLQ 2075
Query: 1703 AEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNE 1755
AE K +A ++ K LQ+ L + + LD E E+ EE + Q E
Sbjct: 2076 AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE 2128
Score = 92.8 bits (229), Expect = 3e-18
Identities = 131/757 (17%), Positives = 311/757 (41%), Gaps = 65/757 (8%)
Query: 41 GTEEVEAELPDSRTKEIEAIHAILRSENE--RLKKLCTDLEEKHEASEIQIKQQSTSYRN 98
G E+E EL R+ + + + ++E E R ++L + E + +E ++++ +
Sbjct: 1967 GKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2026
Query: 99 QLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFH 158
+Q++ + ++ + +++ + A Q + A H A
Sbjct: 2027 AARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQ 2086
Query: 159 DDDMDFGDIISSQQEI-NRLSNEVS---RLESEVGHWRHIAQTSKAQGTDNSDQSEICKL 214
+ + + +Q + ++L E R E R A+ AQ +++E
Sbjct: 2087 QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAE---- 2142
Query: 215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQ 274
LKQ+ ++ + + ++ E +RR + E + ++ + + +
Sbjct: 2143 -----RLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK--QAADAEME 2195
Query: 275 GGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRR 334
E L + ++++ + L+++ E+ + L+++++ + + + A R +
Sbjct: 2196 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2255
Query: 335 EQEQLNVEKRQIME-----ECENLKLECSK-------LQPSAVKQSDTMTEKERILAQSA 382
E + V+ ++ + E EN L LQ A K E R+ S
Sbjct: 2256 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL---SV 2312
Query: 383 SVEEVFRLQQALSD--AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSL------- 433
+ +E RL+Q + A+ + L + ++ +LK E+L+++K L
Sbjct: 2313 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2372
Query: 434 LSQEKEELQMSLLKLNNEYE-VIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKET 492
L ++KE++ L + ++ +++ R + + +E RL L E Q+ +E++
Sbjct: 2373 LQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE--RLKLRVAEMSRAQARAEEDA 2430
Query: 493 L-----IAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQ---DLNDEKKRVH 544
EI E + + AT+ + + L Q+ + D +L++ +L EK+++
Sbjct: 2431 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2490
Query: 545 QLEDDKMDITKE--LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSI 602
Q E + + E VQ+E+L+Q AL L+++ + E ++Q E
Sbjct: 2491 Q-EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQD 2549
Query: 603 QKENLE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL 661
+ + L+E ++ ++++ + R L+ S+ + ++ EAE +++ EL
Sbjct: 2550 EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR--------RQHEAE-EGVRRKQEEL 2600
Query: 662 EQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
+QL + ++ + EN++L + + Q LA + +++ + +TL + +
Sbjct: 2601 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2660
Query: 722 EAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQ 758
+ A+ + + + + + L A L+ LQ
Sbjct: 2661 DGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQ 2697
Score = 83.2 bits (204), Expect = 2e-15
Identities = 194/1114 (17%), Positives = 417/1114 (37%), Gaps = 196/1114 (17%)
Query: 734 EEANKYEKTIEELSNARNLNTSALQLEHEHLIKL----------------NQKKDMEIAE 777
+E ++ ++ I EL + R L A + H ++L QK E+
Sbjct: 1004 QEESRCQRCISELKDIR-LQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEG 1062
Query: 778 LKKNIEQMDTDHKET---------KDVLSSSLE-EQKQLTQLINKKEIFIEKLKERSSKL 827
L K + ++ + ++ L S LE +L Q+ + I++EKLK S +
Sbjct: 1063 LGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI 1122
Query: 828 ------QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAP 881
+E L + + L++ + + T+ E + + S+K +LR + P
Sbjct: 1123 RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLK-----------KLRAQAEAQQP 1171
Query: 882 VADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMD 941
D L E+ + E L++ +E + QLL+ Q + D
Sbjct: 1172 TFDA--------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTD 1223
Query: 942 EFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHE-ERQDIQTDNSDIFQETKVQ 1000
+ + EQ+ + + E + + + + + + Q+ D Q + QE +
Sbjct: 1224 VRQRELEQLGR-QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALL 1282
Query: 1001 SLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQI 1060
IE EK + + ++ + IK+ EL++ + L K +V ++
Sbjct: 1283 E-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ---LEPVASPAKKPKVQSGSES 1338
Query: 1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYH 1120
+ Q+ ++++ ++ +++ + +Q + ++ + L+ E E+ + ++
Sbjct: 1339 VIQEYVDLRTHYSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1397
Query: 1121 KMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKC 1180
K + A A + + E K+L R + ++R ++ +DA
Sbjct: 1398 KQRQLAEAHAQAKAQAEREAKELQQRMQEE--------------VVRREEAAVDA----- 1438
Query: 1181 QTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA 1240
+QQ + ++E QQ+ Q A
Sbjct: 1439 ----------------------------------QQQKRSIQEELQQLR------QSSEA 1458
Query: 1241 QLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCN 1300
++Q + Q +A S+L+++ + + T+ + G E
Sbjct: 1459 EIQAKARQAEAA------ERSRLRIEEEIRVVRLQLEATERQRGGAE------------- 1499
Query: 1301 TKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKD 1360
G+L + + A Q+ E + +V ES Q E+E + E +
Sbjct: 1500 ------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAE 1553
Query: 1361 ATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKS 1420
A +E L + E E +E+++ ++ Q L+ + + +++K
Sbjct: 1554 AA----REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1609
Query: 1421 DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQ 1480
+ E + AV L+E + + ++ E R +E +
Sbjct: 1610 ASFAEKTAQLERSLQEEHV---AVAQLRE----------EAERRAQQQAEAERAREEAER 1656
Query: 1481 ALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTV 1540
L+ +K + LR + ++K+LA + K+KE+ + + ++++++ +
Sbjct: 1657 ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1716
Query: 1541 VFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREAL 1600
Q+ Q LA Q + A + E+ RLR + + Q+ + L L + REA
Sbjct: 1717 AEQELEKQRQLAEGTAQ-QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ----REAA 1771
Query: 1601 AA----EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETA 1656
AA ++ EA+L K +E L S + A E + + + L+ + + +E A
Sbjct: 1772 AATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1831
Query: 1657 LQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEK--QKQLIAEWKKNAENLEG 1714
++++E +Q L+ +E+ A AE E+ ++L A + E
Sbjct: 1832 RLRALAEEAKRQRQLA------------EEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1879
Query: 1715 KVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANS 1774
++ L E A + RL E + ++EE Q++ D++++L L +
Sbjct: 1880 EI-----ALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA------DIEERLAQLRKA 1928
Query: 1775 SEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGS 1808
S+ ++++ + L + E+L L S
Sbjct: 1929 SDSELER--QKGLVEDTLRQRRQVEEEILALKAS 1960
Score = 70.1 bits (170), Expect = 2e-11
Identities = 268/1447 (18%), Positives = 557/1447 (38%), Gaps = 159/1447 (10%)
Query: 474 LNLEAKEQELNQSISEKET-LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKL 532
L++E + +L+ +I E+E L +E E L+ + TK + + +Q N+ D+++
Sbjct: 391 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTK-LQMEAGLCEEQLNQADALLQSD 449
Query: 533 KQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQL 592
+ L K + ++ ++LD + + +I+ + ND+ K + E + ++
Sbjct: 450 VRLLAAGK-----VPQRAGEVERDLD-KADSMIR--LLFNDVQTLKDGRHPQGEQMYRRV 501
Query: 593 NKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLK---- 645
+ E V+I+ E NL LK + +++++ + +Q + DS + LL
Sbjct: 502 YRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEE 561
Query: 646 --------EREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECL 697
E ++ +++ L L++++++ ++ R +CL
Sbjct: 562 NQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCL 621
Query: 698 AGNNQLSLEKNTIVETLKMEKGEIEAE---LCWAKKRLLEEANKYEKTIEELSNARNLNT 754
+L L+ ++ + K +E+ + A K L+ K E+ + + RN N
Sbjct: 622 G---RLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNM 678
Query: 755 SALQLEHEHLIKLNQKKDMEIAELKKNIEQM-DTDHKETKDVLSSSLEEQKQLTQLINKK 813
+A + + L++ + K+ +I EL+ +++ DH V S Q Q + ++
Sbjct: 679 TAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLC 738
Query: 814 EIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLR 873
LKE ++ Q D ++E LQ+ E LR
Sbjct: 739 CCIEAHLKENAAYFQFFSD-------------------------VREAEGQLQKLQEALR 773
Query: 874 EEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE-------DQNQSK 926
+ S + D + + E QLN K HL K + +++ + +
Sbjct: 774 RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGR 833
Query: 927 MQLLQSLQEQKKEMDEFRYQHEQM------------------NATHTQLFL------EKD 962
+ LL ++ E+ + Q+ A + FL E
Sbjct: 834 LPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQ 893
Query: 963 EEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLV 1022
E + L+ + + T H+ D+++ + VQ + + + L K E +R
Sbjct: 894 EAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTL-KPEEQRQA 952
Query: 1023 KGIKERELEIKLLNEKNISLTKQIDQL-SKDEVGKLTQIIQQKDLEIQALHARISSTSHT 1081
E + L + ++ D+L ++ E G + QQ +Q+L S
Sbjct: 953 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL---LQSLEQGAQEESRC 1009
Query: 1082 QDVV--YLQQQLQAYAMEREKVFAVL----NEKTRENSHLKTEYHKMMDIVAAKEAALIK 1135
Q + +LQ A E V + E RE + E K V + +
Sbjct: 1010 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1069
Query: 1136 LQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALS----QKCQTLLAVLQTSS 1191
L E +K+ E S T+++ + K ++ +LS +K +T+ V++ +
Sbjct: 1070 LSAEAEKVLALPEPSPA---APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQ 1126
Query: 1192 TGNEAGGVNSNQFEE------LLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEE 1245
E + Q +E L E + K +KK+ + T ++ E QE
Sbjct: 1127 GAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEV 1186
Query: 1246 LHQLQ-------AQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
+LQ +V + ++L + ++ + + +L+ G++L + S L
Sbjct: 1187 GERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPL 1246
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSA-ECLRASKSEVLSESSELLQQELEELRKSLQ 1357
L Q+ + L Q+ E LR + + L E E +++EE ++ +
Sbjct: 1247 ----GAWLQDARRRQEQIQAMPLADSQAVREQLR--QEQALLEEIERHGEKVEECQRFAK 1300
Query: 1358 EKDATIR--TLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL 1415
+ I+ LQ ++ A+ + K ++S I++ + + +L
Sbjct: 1301 QYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1360
Query: 1416 IKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGK 1475
IK S+ L E E L Q +ER+ +E + K + E +
Sbjct: 1361 IKFISETLRRMEE-------EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQA 1413
Query: 1476 ETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSM 1535
E E + LQ+ + ++R +E + ++K + ++ L++ Q E+ ++
Sbjct: 1414 EREAKELQQRMQE--EVVRREEAAVDAQQQKR-SIQEELQQLRQSSEAEIQAKARQAEAA 1470
Query: 1536 QEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK-------EFRSNQELERLRNHL 1588
+ + ++E V L L+ + + + E+Q LR + + ++ +E ERLR +
Sbjct: 1471 ERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQV 1530
Query: 1589 LESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVV 1648
+D R+ A + ++++ + EK + A+E QA + E Q V
Sbjct: 1531 ---QDESQRKRQAEVELASRVKAEAEAAREK-QRALQALEELRLQAE-EAERRLRQAEVE 1585
Query: 1649 SKQRDETALQLS--VSQEQVKQYALSLANLQMVLEHFQQEEK---AMYSAELEKQKQLIA 1703
++ + AL+ + ++ +++ S A LE QEE A E E++ Q A
Sbjct: 1586 RARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQA 1645
Query: 1704 EWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
E ++ E E ++ Q +EA A + +Q + + + E+ K + E
Sbjct: 1646 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1705
Query: 1764 VQKKLMSLANSSEGKVDKVLMRNLFIGHFHTPKNQRHEVLRLMGSILGVRREEMEQLFHD 1823
+++ + +E +++K R L G E++RL + E+ QL +
Sbjct: 1706 AEEQAVRQRELAEQELEK--QRQLAEGTAQQRLAAEQELIRLRAET--EQGEQQRQLLEE 1761
Query: 1824 DQGGVTR 1830
+ + R
Sbjct: 1762 ELARLQR 1768
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 177 bits (449), Expect = 9e-44
Identities = 260/1195 (21%), Positives = 502/1195 (42%), Gaps = 192/1195 (16%)
Query: 292 KTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECE 351
K +LQ+ + E ++M+ ED+++ ++ AEN+ L ++ QL EK + E+
Sbjct: 847 KVKPLLQVTRQE--EEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQ-- 902
Query: 352 NLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQA-LSDAENEIMRLSSLNQD 410
LQ ++ + R+ A+ +EE+ +A L + E+ +L + +
Sbjct: 903 --------LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQA--ER 952
Query: 411 NSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVI-----KSTATRDISL 465
+A+ L L+ ++E E + L EK + + KL +E V+ K + R + L
Sbjct: 953 KKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKL-L 1011
Query: 466 DSELHDLRLNL---EAKEQELNQSISEKETLIAEI------EELDRQNQEATKHMI---- 512
+ + DL NL E K + L + ++ E++I+E+ EE RQ E K +
Sbjct: 1012 EERISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDA 1071
Query: 513 ---------------LIKDQLSKQQNEGDSIISKLKQDL---NDEKKRVHQLEDDKMDIT 554
+K QL+K++ E + +++L ++ N+ K++ +LE D+
Sbjct: 1072 SDFHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQ 1131
Query: 555 KELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVD------QLNKSQESNVSIQKENLE 608
++LD ++ ++E DL + L+ ++E+ +D +L +E V++ K+ L+
Sbjct: 1132 EDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALD 1191
Query: 609 LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENL 668
E R +E ++ +R + Q++ + + L++ + NL +N LE+ N +L
Sbjct: 1192 --EETRSHEAQVQEMRQKHAQAVEELTEQ------LEQFKRAKANLDKNKQTLEKENADL 1243
Query: 669 K---KVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL 725
+V K E E E +L+ + + E N V L+ E + L
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGML 1303
Query: 726 CWAKKRLLEEA-----------NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDME 774
A+ + ++ A + E EE N++T QLE E L + D E
Sbjct: 1304 NEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER-NSLQDQLDEE 1362
Query: 775 IAELKKNIE--------QMDTDHKETKDVLSS--SLEEQKQ--------LTQLINKKEIF 816
+ E K+N+E Q+ K+ +D S+ +LEE K+ LTQ +K
Sbjct: 1363 M-EAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAA 1421
Query: 817 IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQ 876
+KL++ ++LQ+ELD L L +E+K R + E ++ + R+
Sbjct: 1422 YDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRA 1481
Query: 877 SRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQ 936
A + K L LA + + KE LE K + +ED SK + +++ E
Sbjct: 1482 EAEAREKETKAL----SLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE- 1536
Query: 937 KKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQ-TDNSDIFQ 995
LEK + ++L+ +E++KTQL E ++Q T+++ +
Sbjct: 1537 ----------------------LEKSK--RALETQMEEMKTQLEELEDELQATEDAKLRL 1572
Query: 996 ETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVG 1055
E +Q+L G + DL + + K R+L+ + L+E L + Q +
Sbjct: 1573 EVNMQAL---KGQFERDLQARDEQ---NEEKRRQLQ-RQLHEYETELEDERKQRALAAAA 1625
Query: 1056 KLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME-------REKVFAVLNEK 1108
K KDLE+QA A + + LQ Q++ + E R+++FA E
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685
Query: 1109 TRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES--SGQDMFRETIQNLSRII 1166
++ L+ + ++ + +AA E A + E ++L+ S SG++ ++ + L I
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARI 1745
Query: 1167 REKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQ 1226
+ + E++ + + S++ + Q+ ++L ++ Q
Sbjct: 1746 AQLEEELEEEQGNMEAM-----------------SDRVRKATQQAEQLSNELATERSTAQ 1788
Query: 1227 QVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQ 1286
+ + Q ++ ++ +L+ +LH+++ V SK + L Q E +++ +
Sbjct: 1789 KNESARQQLERQNKELRSKLHEMEGAV------KSKFKSTIAALEAKIAQLEEQVEQEAR 1842
Query: 1287 ELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQ 1346
E S+ Q KD KL I Q+ + Q E + V + L+
Sbjct: 1843 EKQAATKSLKQ----KD---KKLKEILLQVEDERKMAEQYKEQAEKGNARV-----KQLK 1890
Query: 1347 QELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEK 1401
++LEE + Q +A R LQ ++S +E E+ LK K
Sbjct: 1891 RQLEEAEEESQRINANRRKLQRELDEATES-----------NEAMGREVNALKSK 1934
Score = 176 bits (446), Expect = 2e-43
Identities = 243/1192 (20%), Positives = 506/1192 (42%), Gaps = 131/1192 (10%)
Query: 574 LHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ 633
L +T+Q E++++ D+L K++E QK ELKE + Q +L+ +N L + L
Sbjct: 852 LQVTRQ--EEEMQAKEDELQKTKERQ---QKAENELKE-LEQKHSQLTEEKNLLQEQLQA 905
Query: 634 DSNSNFKDTLLKER-EAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQ 692
++ + ++ R A+ + L++ L E+E E + ++ E +K+ D+ Q
Sbjct: 906 ETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQ 965
Query: 693 LEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNL 752
LEE A +L LEK T +K + EI + +L +E E+ I +L+
Sbjct: 966 LEEEEAARQKLQLEKVTAEAKIKKLEDEILV-MDDQNNKLSKERKLLEERISDLTT---- 1020
Query: 753 NTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINK 812
N + + + ++L KL K + I+EL+ +++ + +E + + + + I
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 813 KEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERL 872
+ I +LK + +K +EEL AL + L I +K+ +L ++E H+ + E L
Sbjct: 1081 LQAQIAELKMQLAKKEEELQA---ALAR---LDDEIAQKNNALKKIRELEGHISDLQEDL 1134
Query: 873 REEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQS 932
E++ A K +L E+ L T E + Q++ + Q L ++
Sbjct: 1135 DSERA-----ARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKA 1189
Query: 933 LQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSD 992
L E+ + + Q ++M H Q E E+++ ++ K L + +Q ++ +N+D
Sbjct: 1190 LDEETRSHEA---QVQEMRQKHAQAVEELTEQLEQFKRA----KANLDKNKQTLEKENAD 1242
Query: 993 IFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD 1052
+ E +V + K +A+ + L + E LN+K L +++ ++
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1300
Query: 1053 EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTREN 1112
G L + A + +DV L QLQ +L E+TR+
Sbjct: 1301 --GMLNE-------------AEGKAIKLAKDVASLSSQLQ-------DTQELLQEETRQK 1338
Query: 1113 SHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIE 1172
++ T+ L +L++E L + + E QNL R I +I+
Sbjct: 1339 LNVSTK--------------LRQLEEERNSLQDQLDEE-----MEAKQNLERHISTLNIQ 1379
Query: 1173 IDALSQKCQTLLAVLQTSSTGNEAGGVN----SNQFEELLQERDKLKQQVKKMEEWKQQV 1228
+ +K Q + ++ G + + Q+EE DKL++ ++++ +
Sbjct: 1380 LSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDL 1439
Query: 1229 MTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSY-EQNETKLKNFGQE 1287
+ + N + + L+++ + Q+L + N S D ++ + ETK + +
Sbjct: 1440 VVDLDNQRQLVSNLEKKQRKFD-QLLAEEKNISSKYADERDRAEAEAREKETKALSLARA 1498
Query: 1288 LAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQ 1347
L + + +L T +L +++ L S+ ++ L SK L E ++
Sbjct: 1499 LEEALEAKEELERTNKMLKAEME----DLVSSKDDVGKNVHELEKSK-RALETQMEEMKT 1553
Query: 1348 ELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEI-KQLKEKQDVLQ 1406
+LEEL LQ + L+ N L + +++E+ ++ +QL E + L+
Sbjct: 1554 QLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELE 1613
Query: 1407 KLLKEKDLLIKAKS-------DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG 1459
K++ L AK D L ++ + + LR+ +K+ + ++
Sbjct: 1614 DERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKD----FQRELE 1669
Query: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQ 1519
+ ++I T + E + ++L+ M+ L E + K+ L E+L +E
Sbjct: 1670 DARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAE---RARKQADLEKEELAEELAS 1726
Query: 1520 GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
+G NA+ Q E+ ++ + Q + E Q ++ + D+ ++ Q
Sbjct: 1727 SLSGR-----NAL----------QDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQ 1771
Query: 1580 ELERLRNHLLES-----EDSYTREALAAEDRE--AKLRKKVTVLEEKLVSSSNAMENASH 1632
+ E+L N L ++ R+ L +++E +KL + ++ K S+ A+E
Sbjct: 1772 QAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALE---- 1827
Query: 1633 QASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHF-QQEEKAMY 1691
++ L+EQ+ ++++ L +++K+ L + + + + E + +Q EK
Sbjct: 1828 ---AKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKG-- 1882
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVK 1743
+A +++ K+ + E ++ ++ + LQ LDEA + ++ R L K
Sbjct: 1883 NARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 176 bits (445), Expect = 3e-43
Identities = 281/1242 (22%), Positives = 529/1242 (42%), Gaps = 194/1242 (15%)
Query: 376 RILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS 435
R+ + + +V R ++ + E+E+ + Q AE+ LK LE++ S L+
Sbjct: 843 RLFTKVKPLLQVTRQEEEMQAKEDELQKTKERQQK---AENELK------ELEQKHSQLT 893
Query: 436 QEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIA 495
+EK LQ L + L +E ++R+ L AK+QEL + + E E +
Sbjct: 894 EEKNLLQEQL--------------QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLE 939
Query: 496 EIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITK 555
E E+ +Q Q K M L +Q E ++ KL+ + + ++ +LED+ +
Sbjct: 940 EEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEIL---- 995
Query: 556 ELDVQKEKLIQS----EVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKE 611
+D Q KL + E ++DL + E+K +NL NK ES +S + L+ +E
Sbjct: 996 VMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAKNLTKLKNK-HESMISELEVRLKKEE 1054
Query: 612 HIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL-EQLNENLKK 670
RQ E+L R L D+ S+F + + + +A++ LK L++ E+L L +
Sbjct: 1055 KSRQELEKLKR-------KLEGDA-SDFHEQ-IADLQAQIAELKMQLAKKEEELQAALAR 1105
Query: 671 VAFDVKMENEKLVLACE------DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAE 724
+ ++ +N L E D++ L+ A N+ +K + E L+ K E+E
Sbjct: 1106 LDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELE-- 1163
Query: 725 LCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQ 784
L+++A Q E L K++ E+ LKK +++
Sbjct: 1164 -------------------------DTLDSTATQQE------LRAKREQEVTVLKKALDE 1192
Query: 785 MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEIL 844
H+ + ++E +Q K + +L E+L+++ +A +
Sbjct: 1193 ETRSHE-------AQVQEMRQ-------------KHAQAVEELTEQLEQFKRAKANLDKN 1232
Query: 845 RQTIEEKD-------RSLGSMKEENNHLQEELE-RLREEQSRTA--PVADPKTLDSVTEL 894
+QT+E+++ R LG K+E H +++LE +++E QS+ + A + D V +L
Sbjct: 1233 KQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKL 1292
Query: 895 ASEVSQLNTIKEHLE-EEIKHHQKI--IEDQNQSKMQLLQSLQEQKKEMD-EFRYQHEQM 950
+EV + + E + IK + + + Q Q +LLQ QK + + R E+
Sbjct: 1293 QNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEER 1352
Query: 951 NATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK 1010
N+ QL E+ E ++L++ I + QL + ++ +Q S + +E G ++
Sbjct: 1353 NSLQDQLD-EEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA--------LEEGKKR 1403
Query: 1011 HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQL--SKDEVGKLTQIIQQKDLEI 1068
+ E E L + +E+ L + L +++D L D +L +++K +
Sbjct: 1404 F---QKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKF 1460
Query: 1069 QALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAA 1128
L A + S YA ER++ A EK + L + ++ A
Sbjct: 1461 DQLLAEEKNIS------------SKYADERDRAEAEAREKETKALSLARALEEALE---A 1505
Query: 1129 KEAALIKLQDENKKLSTRFES--SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAV 1186
KE +L+ NK L E S +D + + L + R + +++ + + + L
Sbjct: 1506 KE----ELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 1187 LQTSSTGNEAGGVN----SNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHE-SAQ 1241
LQ + VN QFE LQ RD+ ++ ++ +Q HE +
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQ----------LQRQLHEYETE 1611
Query: 1242 LQEELHQ--LQAQVLVDSDNNSK-LQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQL 1298
L++E Q L A + + K L++ I+ E+ +L+ ++ Q +
Sbjct: 1612 LEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDA 1671
Query: 1299 CNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQEL-EELRKSLQ 1357
++D + + S Q E L A +E + ++L ++EL EEL SL
Sbjct: 1672 RASRDEIFATAKENEKKAKSLEADLMQLQEDLAA--AERARKQADLEKEELAEELASSLS 1729
Query: 1358 EKDATIRTLQENNHRLSDSIA-ATSELERKE---HEQTDSEIKQLKEKQDVLQKLLKEKD 1413
++A LQ+ RL IA ELE ++ +D K ++ + + +L E+
Sbjct: 1730 GRNA----LQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERS 1785
Query: 1414 LLIKAKS--DQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVET 1471
K +S QL N+ +K++E E + K I LE I +L+ E++ +
Sbjct: 1786 TAQKNESARQQLERQNKELRSKLHEME--GAVKSKFKSTIAALEAKIAQLE---EQVEQE 1840
Query: 1472 YRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNA 1531
R K+ ++L++ + K +L + E E+ +A EQ ++ E+G + QL
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVE------DERKMA-EQYKEQAEKG-NARVKQLKRQ 1892
Query: 1532 VKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDK 1573
++ +E++ R ++ L + N A+ EV L+ K
Sbjct: 1893 LEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSK 1934
Score = 175 bits (444), Expect = 3e-43
Identities = 241/1142 (21%), Positives = 496/1142 (43%), Gaps = 134/1142 (11%)
Query: 180 EVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQ------------ 227
+V+R E E+ A+ + Q T Q K +N +KEL+Q SQ
Sbjct: 853 QVTRQEEEMQ-----AKEDELQKTKERQQ----KAENELKELEQKHSQLTEEKNLLQEQL 903
Query: 228 ----EIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETD 283
E+ EM V A +Q+L EI L + E+R ++L+ ++ +++ +
Sbjct: 904 QAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLE 963
Query: 284 LSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEK 343
++ E + Q LQ+EKV + K+++LED+I ++ + + +R +L L
Sbjct: 964 -EQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNL 1022
Query: 344 RQIMEECENLKLECSKLQPSAVKQSDTMTEKE-RILAQSASVEEVFRLQQAL----SDAE 398
+ E+ +NL +KL+ K ++E E R+ + S +E+ +L++ L SD
Sbjct: 1023 AEEEEKAKNL----TKLKN---KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFH 1075
Query: 399 NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKST 458
+I L + +AE LKM+ L++++EELQ +L +L++E +
Sbjct: 1076 EQIADLQA-----QIAE----LKMQ----------LAKKEEELQAALARLDDEIAQKNNA 1116
Query: 459 ATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQL 518
+ L+ + DL+ +L+++ N++ +K L E+E L + ++ ++
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELR 1176
Query: 519 SKQQNEGDSIISKLKQDLNDEKKRVH--QLEDDKMDITKELDVQKEKLIQSEVALNDLHL 576
+K++ E ++ LK+ L DE+ R H Q+++ + + ++ E+L Q + A +L
Sbjct: 1177 AKREQE----VTVLKKAL-DEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
Query: 577 TKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELS---RIRNELMQSLNQ 633
KQ LE + +L +L ++ ++ + +L+ +++ + + S R R EL +++
Sbjct: 1232 NKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHK 1291
Query: 634 DSNSNFKDT-LLKEREA-------EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLA 685
N T +L E E +V +L L + ++L + + +V + +L
Sbjct: 1292 LQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEE 1351
Query: 686 CEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEE 745
++ QL+E + L +T+ L K +++ + + L E +++K IE
Sbjct: 1352 RNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQ-DFASTVEALEEGKKRFQKEIEN 1410
Query: 746 LSNARNLNTSA----------LQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDV 795
L+ +A LQ E + L+ + ++ L+K + D E K++
Sbjct: 1411 LTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNI 1470
Query: 796 LSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSL 855
S +E+ + +KE K + L+E L+ + R N++L+ +E+ L
Sbjct: 1471 SSKYADERDRAEAEAREKE---TKALSLARALEEALEAKEELERTNKMLKAEMED----L 1523
Query: 856 GSMKEE---NNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEI 912
S K++ N H E+ +R E Q + D + +L + L+ +
Sbjct: 1524 VSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQF 1583
Query: 913 KHHQKIIEDQNQSK-MQLLQSLQEQKKEMDEFRYQH-------EQMNATHTQLFLEKDEE 964
+ + ++QN+ K QL + L E + E+++ R Q +++ L L+ D
Sbjct: 1584 ERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSA 1643
Query: 965 IKSLQKTIEQIK------TQLHEERQDIQTDNSDIF-----QETKVQSLNIENGSEKHDL 1013
IK ++ I+Q++ E +D + +IF E K +SL + + DL
Sbjct: 1644 IKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDL 1703
Query: 1014 SKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKD-EVGKLTQIIQQKDLEIQALH 1072
+ AE R +++ EL +L + + Q ++ + + +L + ++++ ++A+
Sbjct: 1704 AAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMS 1763
Query: 1073 ARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAK-EA 1131
R+ TQ L +L +K + + R+N L+++ H+M V +K ++
Sbjct: 1764 DRVRKA--TQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKS 1821
Query: 1132 ALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSS 1191
+ L+ + +L + E REK +L QK + L +L
Sbjct: 1822 TIAALEAKIAQLEEQVEQEA---------------REKQAATKSLKQKDKKLKEILLQVE 1866
Query: 1192 TGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQA 1251
+ Q E+ +LK+Q+++ EE Q++ + +Q E + E +
Sbjct: 1867 DERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGR 1926
Query: 1252 QV 1253
+V
Sbjct: 1927 EV 1928
Score = 162 bits (409), Expect = 4e-39
Identities = 258/1201 (21%), Positives = 510/1201 (42%), Gaps = 186/1201 (15%)
Query: 76 TDLEEKHEASEIQI---KQQSTSYRNQLQQKEVEISHLKARQIALQDQL---LKLQSAAQ 129
T EE+ +A E ++ K++ N+L++ E + S L + LQ+QL +L + A+
Sbjct: 855 TRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAE 914
Query: 130 SVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEINRLSNEVSRLESEVG 189
+ A I H A +++ D G + Q E +++ ++ LE ++
Sbjct: 915 EMR-----VRLAAKKQELEEILHEMEARLEEEEDRGQQL--QAERKKMAQQMLDLEEQLE 967
Query: 190 HWRHIAQ-------TSKAQ------------GTDNSDQSEICKLQNIIKELKQNRSQEID 230
Q T++A+ +N E L+ I +L N ++E +
Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE-E 1026
Query: 231 DHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEM 290
+ ++ L+N H+ ++E+ R ++E E+ +ELE L ++ +E D S +E
Sbjct: 1027 EKAKNLTKLKNKHESMISELEVRLKKE----EKSRQELEKLKRK-----LEGDASDFHEQ 1077
Query: 291 QKTIQVLQIE-KVESTKKMEQLE-----------------DKIKDINKKLSSAENDRDIL 332
+Q E K++ KK E+L+ KI+++ +S + D D
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137
Query: 333 RREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQ 392
R + + +KR + EE E LK E S Q + ++E +EV L++
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE---------QEVTVLKK 1188
Query: 393 AL-SDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNE 451
AL + + ++ + Q ++ A + +L ++E ++ K+ L + K+ L+ L E
Sbjct: 1189 ALDEETRSHEAQVQEMRQKHAQAVE--ELTEQLEQFKRAKANLDKNKQTLEKENADLAGE 1246
Query: 452 YEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHM 511
V+ E+ + LEA+ QEL S+ E AE
Sbjct: 1247 LRVLGQA-------KQEVEHKKKKLEAQVQELQSKCSDGERARAE--------------- 1284
Query: 512 ILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVAL 571
+ D++ K QNE +S+ LN+ + + +L D ++ +L +E L +
Sbjct: 1285 --LNDKVHKLQNEVESVTGM----LNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQK 1338
Query: 572 NDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSL 631
++ ++LE++ +L DQL++ E+ K+NLE HI +LS + +L
Sbjct: 1339 LNVSTKLRQLEEERNSLQDQLDEEMEA-----KQNLE--RHISTLNIQLSDSKKKL---- 1387
Query: 632 NQDSNSNFK--DTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDV 689
QD S + + K + E+ NL Q E + L+K ++ E + LV+ ++
Sbjct: 1388 -QDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQ 1446
Query: 690 RH---QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEEL 746
R LE+ +QL E+ I E+ EAE + + L A E+ +E
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506
Query: 747 SNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL 806
N L+ E E L+ + EL+K+ ++T +E K L LE++ Q
Sbjct: 1507 EELERTN-KMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQL-EELEDELQA 1564
Query: 807 TQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQ 866
T+ +KL+ E++ + + L+ E+ + ++ + + +
Sbjct: 1565 TE---------------DAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYE 1609
Query: 867 EELERLREEQSRTAPV-----ADPKTLDSVTELASEVSQLNTIKE--HLEEEIKHHQKII 919
ELE R++++ A D K L+ + A + + IK+ L+ ++K Q+ +
Sbjct: 1610 TELEDERKQRALAAAAKKKLEGDLKDLELQADSAIK-GREEAIKQLRKLQAQMKDFQREL 1668
Query: 920 EDQNQSKMQLLQSLQEQKK-----EMDEFRYQHEQMNA--THTQLFLEKDEEIKSLQKTI 972
ED S+ ++ + +E +K E D + Q + A Q LEK+E + L ++
Sbjct: 1669 EDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSL 1728
Query: 973 EQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEI 1032
+ L +E++ ++ + + +E + + N+E S++ + + E+L +
Sbjct: 1729 SG-RNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATE---- 1783
Query: 1033 KLLNEKNISLTKQIDQLSKDEVGKLTQI---IQQK-DLEIQALHARISSTSHTQDVVYLQ 1088
+ +KN S +Q+++ +K+ KL ++ ++ K I AL A+I+ L+
Sbjct: 1784 RSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQ---------LE 1834
Query: 1089 QQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFE 1148
+Q++ A E++ L +K + K+ +I L++++DE K E
Sbjct: 1835 EQVEQEAREKQAATKSLKQKDK----------KLKEI-------LLQVEDERKMAEQYKE 1877
Query: 1149 SSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELL 1208
+ + R ++ L R + E + E ++ + L L ++ NEA G N + L
Sbjct: 1878 QAEKGNAR--VKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Query: 1209 Q 1209
+
Sbjct: 1936 R 1936
Score = 151 bits (381), Expect = 7e-36
Identities = 218/1060 (20%), Positives = 434/1060 (40%), Gaps = 142/1060 (13%)
Query: 757 LQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQL--------TQ 808
+Q + + L K +++ ELK+ +EQ + E K++L L+ + +L +
Sbjct: 861 MQAKEDELQKTKERQQKAENELKE-LEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVR 919
Query: 809 LINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
L KK+ E L E ++L+EE D+ Q + + + Q + + + L EE
Sbjct: 920 LAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQL-----------EE 968
Query: 869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQ 928
E R++ A+ K + +L E+ ++ L +E +K++E++
Sbjct: 969 EEAARQKLQLEKVTAEAK----IKKLEDEILVMDDQNNKLSKE----RKLLEERISDLTT 1020
Query: 929 LLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE----EIKSLQKTIEQIKTQLHEERQ 984
L +E+ K + + + +HE M + ++ L+K+E E++ L++ +E + HE+
Sbjct: 1021 NLAEEEEKAKNLTKLKNKHESM-ISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA 1079
Query: 985 DIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTK 1044
D+Q +++ + + ++ + D A+ +K I+E E I L E
Sbjct: 1080 DLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQE------- 1132
Query: 1045 QIDQLSKDEVGKLTQIIQQKDL--EIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVF 1102
L + + Q++DL E++AL + T D QQ+L+A + V
Sbjct: 1133 ---DLDSERAARNKAEKQKRDLGEELEALKTELEDTL---DSTATQQELRAKREQEVTVL 1186
Query: 1103 A-VLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRET--I 1159
L+E+TR + + + +M A L + ++ K+ + + Q + +E +
Sbjct: 1187 KKALDEETRSH---EAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADL 1243
Query: 1160 QNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVK 1219
R++ + E++ +K + + LQ+ + E N LQ ++++
Sbjct: 1244 AGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQ--NEVESVTG 1301
Query: 1220 KMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNET 1279
+ E + + + +++ S+QLQ+ Q L+ + KL V T
Sbjct: 1302 MLNEAEGKAIKLAKDVASLSSQLQD------TQELLQEETRQKLNVS------------T 1343
Query: 1280 KLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLS 1339
KL+ +E +Q + + K L + ++ QLS + A S E L
Sbjct: 1344 KLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA-----STVEALE 1398
Query: 1340 ESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLK 1399
E + Q+E+E L + +EK A L++ +RL ++ D + L
Sbjct: 1399 EGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQ--------------QELDDLVVDLD 1444
Query: 1400 EKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIG 1459
++ ++ L K++ K DQLL+ +N ++K + +A KE
Sbjct: 1445 NQRQLVSNLEKKQ-----RKFDQLLAEEKNISSKYADERDRAEAEAREKET--------- 1490
Query: 1460 KLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQ 1519
K + R E +A +E M+ E E S + +L K K
Sbjct: 1491 -------KALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRA 1543
Query: 1520 GKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQ 1579
+T ++ ++ ++ ++++ Q D + Q + ++Q ++ +
Sbjct: 1544 LET-QMEEMKTQLEELEDE---LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRR 1599
Query: 1580 ELER-LRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQA---S 1635
+L+R L + E ED + ALAA ++ KL + LE + S+ E A Q
Sbjct: 1600 QLQRQLHEYETELEDERKQRALAAAAKK-KLEGDLKDLELQADSAIKGREEAIKQLRKLQ 1658
Query: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAEL 1695
Q++ Q +L RDE ++++ K L LQ E E+A A+L
Sbjct: 1659 AQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQ---EDLAAAERARKQADL 1715
Query: 1696 EKQK---QLIAEWK-KNA-----ENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQ 1746
EK++ +L + +NA LE ++ L+E L+E +++ S + + EQ
Sbjct: 1716 EKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQ 1775
Query: 1747 IEE-------LKRQNELRQEMLDDVQKKLMSLANSSEGKV 1779
+ ++NE ++ L+ K+L S + EG V
Sbjct: 1776 LSNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAV 1815
Score = 127 bits (318), Expect = 1e-28
Identities = 199/940 (21%), Positives = 390/940 (41%), Gaps = 160/940 (17%)
Query: 64 LRSENERLKKLCTDLEEKHEAS----EIQIKQQSTSYRN--QLQQK-EVEISHLKARQIA 116
L E E+ K L T L+ KHE+ E+++K++ S + +L++K E + S +
Sbjct: 1022 LAEEEEKAKNL-TKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIAD 1080
Query: 117 LQDQL--LKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAFHDDDMDFGDIISSQQEI 174
LQ Q+ LK+Q A + A + D + ++ ++I
Sbjct: 1081 LQAQIAELKMQLAKKEEELQAALARL--------------------DDEIAQKNNALKKI 1120
Query: 175 NRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICK--LQNII------KELKQNRS 226
L +S L+ ++ R ++ Q D ++ E K L++ + +EL+ R
Sbjct: 1121 RELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKRE 1180
Query: 227 QEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSK 286
QE+ + + +H+ ++ E+ ++H + + + E++E+ + +T +
Sbjct: 1181 QEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKE 1239
Query: 287 IYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQI 346
++ ++VL K E K ++LE +++++ K S E R L + +L E +
Sbjct: 1240 NADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESV 1299
Query: 347 MEECENLKLECSKLQPSAVKQSDTMTEKERILAQ--------SASVEEVFRLQQALSDAE 398
+ + KL S + + + +L + S + ++ + +L D
Sbjct: 1300 TGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQL 1359
Query: 399 NEIMR--------LSSLNQDNSLAEDNLK-LKMRIEVLEKEKSLLSQEKEELQMSLLKLN 449
+E M +S+LN S ++ L+ +E LE+ K +E E L +
Sbjct: 1360 DEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKA 1419
Query: 450 NEYEVIKSTATRDISLDSELHDLRL----------NLEAKEQELNQSISEKETLIAEI-E 498
Y+ ++ T R L EL DL + NLE K+++ +Q ++E++ + ++ +
Sbjct: 1420 AAYDKLEKTKNR---LQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYAD 1476
Query: 499 ELDRQNQEA----TKHMILI---------KDQLSKQQNEGDSIISKLKQDLNDEKKRVHQ 545
E DR EA TK + L K++L + + + L +D K VH+
Sbjct: 1477 ERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHE 1536
Query: 546 LEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKS-QESNVSIQK 604
LE K + +++ K +L + E L K +LE ++ L Q + Q + ++
Sbjct: 1537 LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEE 1596
Query: 605 ENLELKEHIRQNEEELSRIRNE--LMQSLNQDSNSNFKD------TLLKEREAEVRNLKQ 656
+ +L+ + + E EL R + L + + + KD + +K RE ++ L++
Sbjct: 1597 KRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRK 1656
Query: 657 NLSELEQLNENLKKVA------FDVKMENEKLVLACEDVRHQLEECLAG----NNQLSLE 706
++++ L+ F ENEK + E QL+E LA Q LE
Sbjct: 1657 LQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLE 1716
Query: 707 KNTIVE----------TLKMEKGEIEAELCWAKKRLLEEANKYE----------KTIEEL 746
K + E L+ EK +EA + ++ L EE E + E+L
Sbjct: 1717 KEELAEELASSLSGRNALQDEKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQL 1776
Query: 747 SN--------ARNLNTSALQLEHEHLIKLNQKKDME-----------------IAELKKN 781
SN A+ ++ QLE ++ ++ +ME IA+L++
Sbjct: 1777 SNELATERSTAQKNESARQQLERQNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQ 1836
Query: 782 IEQ-----------MDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
+EQ + K+ K++L +E+K Q + E ++K+ +L EE
Sbjct: 1837 VEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQL-EE 1895
Query: 831 LDKYSQALRKN-EILRQTIEEKDRSLGSMKEENNHLQEEL 869
++ SQ + N L++ ++E S +M E N L+ +L
Sbjct: 1896 AEEESQRINANRRKLQRELDEATESNEAMGREVNALKSKL 1935
Score = 119 bits (297), Expect = 4e-26
Identities = 227/1059 (21%), Positives = 426/1059 (40%), Gaps = 174/1059 (16%)
Query: 741 KTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSL 800
K +E N + S + L L +++D++I ++ + M + K +
Sbjct: 759 KALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDVIMAFQAMCRGYLARK----AFA 814
Query: 801 EEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKE 860
+ Q+QLT + + LK R+ + K L ++ RQ +E
Sbjct: 815 KRQQQLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLL---QVTRQ------------EE 859
Query: 861 ENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE 920
E ++EL++ +E Q K + + EL + SQL K L+E+++ ++
Sbjct: 860 EMQAKEDELQKTKERQQ--------KAENELKELEQKHSQLTEEKNLLQEQLQAETELYA 911
Query: 921 DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLH 980
+ + +++L QE ++ + E + E+ QL E+ K + + + ++ QL
Sbjct: 912 EAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAER----KKMAQQMLDLEEQLE 967
Query: 981 EERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL--EIKLLNEK 1038
EE E Q L +E + + + K E E LV + +L E KLL E+
Sbjct: 968 EE-------------EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEER 1014
Query: 1039 NISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHT-QDVVYLQQQLQAYAME 1097
LT + + +++ LT++ + + I L R+ + Q++ L+++L+ A +
Sbjct: 1015 ISDLTTNLAE-EEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASD 1073
Query: 1098 REKVFAVLNEKTRE--------NSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES 1149
+ A L + E L+ ++ D +A K AL K+++ +S E
Sbjct: 1074 FHEQIADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQED 1133
Query: 1150 SGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQ 1209
D R + R+ E++AL + + L ST + +EL
Sbjct: 1134 L--DSERAARNKAEKQKRDLGEELEALKTELEDTL-----DSTATQ---------QELRA 1177
Query: 1210 ERDKLKQQVKK-MEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYT 1268
+R++ +KK ++E + VQ M+ + AQ EEL + Q +K +D
Sbjct: 1178 KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQF-----KRAKANLD-- 1230
Query: 1269 GLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAE 1328
+N+ L+ +LA +GQ + KL+ +L S E
Sbjct: 1231 -------KNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKC----SDGE 1279
Query: 1329 CLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEH 1388
RA L++ LQ E+E + L E + L ++ LS + T EL ++E
Sbjct: 1280 RARAE----LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEET 1335
Query: 1389 EQ---TDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVT 1445
Q ++++QL+E+++ LQ L E+ +A
Sbjct: 1336 RQKLNVSTKLRQLEEERNSLQDQLDEE----------------------------MEAKQ 1367
Query: 1446 NLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKE 1505
NL+ I L + + K + + T +AL+E +F +E E +E
Sbjct: 1368 NLERHISTLNIQLSDSKKKLQDFASTV-------EALEEGKKRFQ---KEIENLTQQYEE 1417
Query: 1506 KALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQN 1565
KA A+++L K K N ++ + VV + Q++ L++KQ + L
Sbjct: 1418 KAAAYDKLEKTK------------NRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLA 1465
Query: 1566 EVQRLRDK--EFRSNQELE-RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVS 1622
E + + K + R E E R + S EAL A++ + K + E LVS
Sbjct: 1466 EEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNKMLKAEMEDLVS 1525
Query: 1623 SSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEH 1682
S + + H+ +L+ Q+ + Q +E +L +++ + +++ L+ E
Sbjct: 1526 SKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLEVNMQALKGQFER 1585
Query: 1683 ------FQQEEKAM--------YSAELE---KQKQLIAEWKKNAENLEGKVISLQECLDE 1725
Q EEK Y ELE KQ+ L A KK LEG + L+ +
Sbjct: 1586 DLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKK---KLEGDLKDLEL---Q 1639
Query: 1726 ANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDV 1764
A++A+ +QL + Q+++ +R+ E + D++
Sbjct: 1640 ADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEI 1678
Score = 105 bits (262), Expect = 4e-22
Identities = 168/769 (21%), Positives = 319/769 (41%), Gaps = 102/769 (13%)
Query: 1055 GKLTQIIQQKDLEI----QALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110
G L + +++DL+I A A + QQQL A + + A L +
Sbjct: 780 GVLAHLEEERDLKITDVIMAFQAMCRGYLARKAFAKRQQQLTAMKVIQRNCAAYLKLRNW 839
Query: 1111 ENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKD 1170
+ L T+ ++ + +E K +DE +K R + ++ +E Q S++ EK+
Sbjct: 840 QWWRLFTKVKPLLQVTRQEEEMQAK-EDELQKTKER-QQKAENELKELEQKHSQLTEEKN 897
Query: 1171 I---------EIDA--------LSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDK 1213
+ E+ A L+ K Q L +L E ++ ++L ER K
Sbjct: 898 LLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEE---EEDRGQQLQAERKK 954
Query: 1214 LKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQS 1273
+ QQ+ +EE ++ Q +Q E + ++ +L+ ++LV D N+KL + L
Sbjct: 955 MAQQMLDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLL--- 1011
Query: 1274 YEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRAS 1333
E ++ + LA+ + L K+ S++ S
Sbjct: 1012 ----EERISDLTTNLAEEEEKAKNLTKLKN-------------KHESMI----------S 1044
Query: 1334 KSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDS 1393
+ EV + E +QELE+L++ L E DA+ + + +++D A +EL+
Sbjct: 1045 ELEVRLKKEEKSRQELEKLKRKL-EGDAS-----DFHEQIADLQAQIAELKM-------- 1090
Query: 1394 EIKQLKEKQDVLQKLLKEKDLLIKAKSDQL--LSSNENFTNKVNENELLRQAVTNLKERI 1451
QL +K++ LQ L D I K++ L + E + + E+ +A N E+
Sbjct: 1091 ---QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEK- 1146
Query: 1452 LILEMDIGK----LKGENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHS----- 1502
+ D+G+ LK E E +++ + E +A +E + ++E H
Sbjct: 1147 --QKRDLGEELEALKTELEDTLDS-TATQQELRAKREQEVTVLKKALDEETRSHEAQVQE 1203
Query: 1503 MKEK-ALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENT 1561
M++K A A E+L ++ EQ K + N N ++++++ E + A ++ + +
Sbjct: 1204 MRQKHAQAVEELTEQLEQFKRAKANLDKNK-QTLEKENADLAGELRVLGQAKQEVEHKKK 1262
Query: 1562 ALQNEVQRLRDK---EFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEE 1618
L+ +VQ L+ K R+ EL + L +S T AE + KL K V L
Sbjct: 1263 KLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSS 1322
Query: 1619 KLVSSSNAMENASHQ---ASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLAN 1675
+L + ++ + Q S ++ L+E+ N + Q DE + + + L++
Sbjct: 1323 QLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSD 1382
Query: 1676 LQMVLEHFQ------QEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAA 1729
+ L+ F +E K + E+E Q E + LE LQ+ LD+
Sbjct: 1383 SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVD 1442
Query: 1730 LDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSEGK 1778
LD+ +L L+ K+ + ++L + + D + + + A E K
Sbjct: 1443 LDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETK 1491
Score = 66.2 bits (160), Expect = 3e-10
Identities = 94/472 (19%), Positives = 196/472 (41%), Gaps = 72/472 (15%)
Query: 1367 QENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLL---IKAKSDQL 1423
+E D + T E ++K ++E+K+L++K +L +EK+LL ++A+++
Sbjct: 858 EEEMQAKEDELQKTKERQQK----AENELKELEQKHS---QLTEEKNLLQEQLQAETELY 910
Query: 1424 LSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQ 1483
+ E + + L + + ++ R+ E +L+ E +K+ + E + + +
Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970
Query: 1484 ETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQ 1543
K + E K K L E L+ + + K + +LL S + +
Sbjct: 971 AARQKLQL-----EKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEE 1025
Query: 1544 QERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALA-- 1601
+E+ + + LK K + ++ +E++ KE +S QELE+L+ LE + S E +A
Sbjct: 1026 EEKAKNLTKLKNK---HESMISELEVRLKKEEKSRQELEKLKRK-LEGDASDFHEQIADL 1081
Query: 1602 ----------AEDREAKLRKKVTVLEEKLVSSSNAMEN--------------------AS 1631
+E +L+ + L++++ +NA++ A
Sbjct: 1082 QAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAAR 1141
Query: 1632 HQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMY 1691
++A Q L E+L + + ++T + QE + + L+ L+ + +A
Sbjct: 1142 NKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSHEAQV 1201
Query: 1692 SAELEKQKQLIAEWKKNAENLEGKVISL---QECLDEANAALDSASRLTEQLDVK----- 1743
+K Q + E + E + +L ++ L++ NA L R+ Q +
Sbjct: 1202 QEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 1744 ---EEQIEELKRQ----NELRQEMLDDVQK------KLMSLANSSEGKVDKV 1782
E Q++EL+ + R E+ D V K + + N +EGK K+
Sbjct: 1262 KKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKL 1313
Score = 47.8 bits (112), Expect = 1e-04
Identities = 65/349 (18%), Positives = 128/349 (36%), Gaps = 23/349 (6%)
Query: 38 LMEGTEEVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTSYR 97
L E E EL D R + A A + E + LK L + + E IKQ +
Sbjct: 1601 LQRQLHEYETELEDERKQRALAAAAKKKLEGD-LKDLELQADSAIKGREEAIKQLR---K 1656
Query: 98 NQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPSGAGVPATTASSSFAYGISHHPSAF 157
Q Q K+ + AR A +D++ + A A
Sbjct: 1657 LQAQMKDFQRELEDAR--ASRDEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQAD 1714
Query: 158 HDDDMDFGDIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNI 217
+ + ++ SS N L +E RLE+ + + + QG + + K
Sbjct: 1715 LEKEELAEELASSLSGRNALQDEKRRLEARIAQLEE--ELEEEQGNMEAMSDRVRKATQQ 1772
Query: 218 IKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGS 277
++L + E Q S Q +Q + ++ E+E ++
Sbjct: 1773 AEQLSNELATERSTAQKNESARQQLERQN------------KELRSKLHEMEGAVKSKFK 1820
Query: 278 GVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQE 337
I +KI ++++ ++ EK +TK ++Q + K+K+I ++ + + + E
Sbjct: 1821 STIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAE 1880
Query: 338 QLNVEKRQIMEECENLKLECSKLQPSAVK---QSDTMTEKERILAQSAS 383
+ N +Q+ + E + E ++ + K + D TE + + +
Sbjct: 1881 KGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEATESNEAMGREVN 1929
Score = 38.1 bits (87), Expect = 0.086
Identities = 35/148 (23%), Positives = 69/148 (46%), Gaps = 10/148 (6%)
Query: 1636 VQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQ-QEEKAMYSAE 1694
+QV +E++ Q E LQ + ++Q + L ++ +H Q EEK + +
Sbjct: 852 LQVTRQEEEM-----QAKEDELQKTKERQQKAENELK----ELEQKHSQLTEEKNLLQEQ 902
Query: 1695 LEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQN 1754
L+ + +L AE ++ L K L+E L E A L+ +QL + +++ +
Sbjct: 903 LQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDL 962
Query: 1755 ELRQEMLDDVQKKLMSLANSSEGKVDKV 1782
E + E + ++KL ++E K+ K+
Sbjct: 963 EEQLEEEEAARQKLQLEKVTAEAKIKKL 990
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.321
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 64,981,478
Number of Sequences: 37866
Number of extensions: 3035713
Number of successful extensions: 52526
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 545
Number of HSP's successfully gapped in prelim test: 1564
Number of HSP's that attempted gapping in prelim test: 16091
Number of HSP's gapped (non-prelim): 15068
length of query: 1979
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1862
effective length of database: 13,817,196
effective search space: 25727618952
effective search space used: 25727618952
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.