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Search of human proteins with 189571583
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|189571583 intercellular adhesion molecule 5 precursor [Homo
sapiens]
(924 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|189571583 intercellular adhesion molecule 5 precursor [Homo s... 1880 0.0
gi|167466207 intercellular adhesion molecule 3 precursor [Homo s... 469 e-132
gi|167466198 intercellular adhesion molecule 1 precursor [Homo s... 430 e-120
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 144 3e-34
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 142 1e-33
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 134 4e-31
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 134 4e-31
gi|118572606 hemicentin 1 [Homo sapiens] 130 7e-30
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 118 3e-26
gi|153082722 intercellular adhesion molecule 2 precursor [Homo s... 114 4e-25
gi|153082719 intercellular adhesion molecule 2 precursor [Homo s... 114 4e-25
gi|153082699 intercellular adhesion molecule 2 precursor [Homo s... 114 4e-25
gi|153082686 intercellular adhesion molecule 2 precursor [Homo s... 114 4e-25
gi|153082696 intercellular adhesion molecule 2 precursor [Homo s... 114 4e-25
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 101 3e-21
gi|157168355 CD22 molecule [Homo sapiens] 98 3e-20
gi|4507875 vascular cell adhesion molecule 1 isoform a precursor... 96 2e-19
gi|237858682 neurofascin isoform 6 precursor [Homo sapiens] 92 3e-18
gi|237858680 neurofascin isoform 5 precursor [Homo sapiens] 92 3e-18
gi|237858679 neurofascin isoform 3 precursor [Homo sapiens] 91 5e-18
gi|89903008 neurofascin isoform 4 precursor [Homo sapiens] 91 5e-18
gi|237858677 neurofascin isoform 2 precursor [Homo sapiens] 91 6e-18
gi|237858675 neurofascin isoform 1 precursor [Homo sapiens] 91 6e-18
gi|4504561 intercellular adhesion molecule 4 isoform 1 precursor... 91 6e-18
gi|12545402 intercellular adhesion molecule 4 isoform 2 precurso... 90 8e-18
gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo ... 88 4e-17
gi|109150416 peroxidasin [Homo sapiens] 87 5e-17
gi|33519481 neural cell adhesion molecule 2 precursor [Homo sapi... 85 3e-16
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 84 5e-16
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 84 5e-16
>gi|189571583 intercellular adhesion molecule 5 precursor [Homo
sapiens]
Length = 924
Score = 1880 bits (4869), Expect = 0.0
Identities = 924/924 (100%), Positives = 924/924 (100%)
Query: 1 MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCP 60
MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCP
Sbjct: 1 MPGPSPGLRRALLGLWAALGLGLFGLSAVSQEPFWADLQPRVAFVERGGSLWLNCSTNCP 60
Query: 61 RPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRP 120
RPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRP
Sbjct: 61 RPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRP 120
Query: 121 DRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAV 180
DRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAV
Sbjct: 121 DRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAV 180
Query: 181 LTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLE 240
LTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLE
Sbjct: 181 LTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLE 240
Query: 241 VGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQL 300
VGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQL
Sbjct: 241 VGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQL 300
Query: 301 VCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAA 360
VCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAA
Sbjct: 301 VCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAA 360
Query: 361 VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWT 420
VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWT
Sbjct: 361 VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWT 420
Query: 421 WPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAV 480
WPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAV
Sbjct: 421 WPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAV 480
Query: 481 KDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLL 540
KDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLL
Sbjct: 481 KDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLL 540
Query: 541 RVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDG 600
RVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDG
Sbjct: 541 RVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDG 600
Query: 601 KPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVV 660
KPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVV
Sbjct: 601 KPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVV 660
Query: 661 SAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDA 720
SAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDA
Sbjct: 661 SAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSREDA 720
Query: 721 GTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQIS 780
GTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQIS
Sbjct: 721 GTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQIS 780
Query: 781 WRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAV 840
WRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAV
Sbjct: 781 WRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAV 840
Query: 841 GGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGG 900
GGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGG
Sbjct: 841 GGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGGAGGAAGAEGG 900
Query: 901 PEAAGGAAESPAEGEVFAIQLTSA 924
PEAAGGAAESPAEGEVFAIQLTSA
Sbjct: 901 PEAAGGAAESPAEGEVFAIQLTSA 924
>gi|167466207 intercellular adhesion molecule 3 precursor [Homo
sapiens]
Length = 547
Score = 469 bits (1208), Expect = e-132
Identities = 240/460 (52%), Positives = 311/460 (67%), Gaps = 6/460 (1%)
Query: 29 VSQEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLV 88
V + F ++P+ + GGSL++NCST+CP E+ LETSL + G+ W A L
Sbjct: 27 VQGQEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLS 86
Query: 89 DIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAG 148
++ ++ +C C + I ++ P+RVEL PLPPWQPVG+NFTL C+V
Sbjct: 87 NVTG-NSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGS 145
Query: 149 PRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHG 208
PR SLT+ LLR +EL R+ EP A +TATVLA R+DHGA FSCR ELD++P G
Sbjct: 146 PRTSLTVVLLRWEEELSRQPAVEEP-----AEVTATVLASRDDHGAPFSCRTELDMQPQG 200
Query: 209 LGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGD 268
LGLF N+SAPR+LRTF L PRL APR LEV + PV CTLDGLFPASEA+VYLALGD
Sbjct: 201 LGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGD 260
Query: 269 QNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLT 328
Q L+ V GD ATATATA A+QEGAR++VCNVTLGGE RE REN+T++SF P++
Sbjct: 261 QMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVN 320
Query: 329 LSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLD 388
LSEP+ EG VTV+C AGA+ VTL+GVPAA PGQPAQLQLNATE+DD RSFFC ATL+
Sbjct: 321 LSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLE 380
Query: 389 VDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDG 448
VDGE L +N S +LRVLY P++D + CP+ W + L+C+ARGNP P + C +
Sbjct: 381 VDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGS 440
Query: 449 GAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVE 488
+ +G+ V +GTY+C+A++ +G+ V + +E
Sbjct: 441 SREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE 480
Score = 64.7 bits (156), Expect = 4e-10
Identities = 97/381 (25%), Positives = 145/381 (38%), Gaps = 51/381 (13%)
Query: 228 PDAPRLAA-PRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATA 286
P+ LA P VG + C ++ P + V L ++ LS +E A V TA
Sbjct: 117 PERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEV-TA 175
Query: 287 TATASAEQEGARQLVCNVTLGGE--------NRETRENVTIYSFPAPLLTLSEPSVSEGQ 338
T AS + GA C L + N + + P L P E +
Sbjct: 176 TVLASRDDHGA-PFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVE 234
Query: 339 MV-TVTC-------AAGAQALVTL--EGVPAAVPGQPAQLQLNAT-----ENDDRRSFFC 383
V C A+ AQ + L + + A V L AT + + R C
Sbjct: 235 TSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVC 294
Query: 384 DATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHC 443
+ TL GE + + P ++ S+ T EG T+ C A + ++
Sbjct: 295 NVTLG--GERREARENLTVFSFLGPIVNLSEP----TAHEGSTVTVSCMAGARVQVTL-- 346
Query: 444 ARSDGGAVLALGLLGPVTRALSGT-------YRCKAAND-QGEAV---KDVTLTVEYAPA 492
DG A G P L+ T + C A + GE + V L V Y P
Sbjct: 347 ---DGVPAAAPGQ--PAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPK 401
Query: 493 LDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGL-LRVAREHAGTYR 551
+D CP+ + W + T L C A G P P++ C++ G V G+ V H GTY+
Sbjct: 402 IDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQ 461
Query: 552 CEATNPRGSAAKNVAVTVEYG 572
C+A++ RG V + +E G
Sbjct: 462 CQASSSRGKYTLVVVMDIEAG 482
Score = 59.7 bits (143), Expect = 1e-08
Identities = 110/475 (23%), Positives = 180/475 (37%), Gaps = 83/475 (17%)
Query: 238 LLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGA 297
+L G V+C+ D P+SE +AL + +LS ++ G + A + + G
Sbjct: 42 VLSAGGSLFVNCSTD--CPSSEK---IAL-ETSLSKELVASGMGWAAFNLSNVT----GN 91
Query: 298 RQLVCNVTLGGENRETRENVTIYSFPAPL-LTLSEPSVSEGQMVTVTCAAGAQALVT--- 353
+++C+V G N+T+Y P + L P GQ T+ C + T
Sbjct: 92 SRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLT 151
Query: 354 ---------LEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVD--GETLIKNRSA-- 400
L PA + A+ +D F C LD+ G L N SA
Sbjct: 152 VVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPR 211
Query: 401 ELRV---------LYAPRLDDSDCPRSWTWPEGPEQTLRCEARG---NPEPSVHCARSD- 447
+LR L APR + + +WP + C G E V+ A D
Sbjct: 212 QLRTFVLPVTPPRLVAPRFLEVET----SWP------VDCTLDGLFPASEAQVYLALGDQ 261
Query: 448 --GGAVLALGLLGPVTRALSGTYRCKAANDQG--EAVKDVTLTVEYAPALDSVGCPERI- 502
V+ G +T + T R A+ +G E V +VTL E A +++ +
Sbjct: 262 MLNATVMNHG--DTLTATATATAR---ADQEGAREIVCNVTLGGERREARENLTVFSFLG 316
Query: 503 --------TWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREHAG-TYRCE 553
T EG+ ++SC+A + V + G + L G ++ C
Sbjct: 317 PIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCS 376
Query: 554 ATNPRGSAA----KNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCV 609
AT +V + V YGP+ + +CP + W + + + C+ G P P ++C+
Sbjct: 377 ATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCL 436
Query: 610 GSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAES 664
G + E +P+ P V G Y C A++ G VV+ E+
Sbjct: 437 KEGSSRE---VPVG-------IPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEA 481
Score = 54.7 bits (130), Expect = 4e-07
Identities = 59/228 (25%), Positives = 88/228 (38%), Gaps = 37/228 (16%)
Query: 532 LGAVIEGLLRVAREHAGTYRCEAT--NPRGSAAKNVAVTVEYGP--RFEEPSCPSNWTWV 587
L A R +E A C T R A +N+ V GP EP+
Sbjct: 274 LTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAH------ 327
Query: 588 EGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNA 647
EGS SC + Q ++ V + + L L + + C+A
Sbjct: 328 EGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRS----------FFCSA 377
Query: 648 T--------NRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPG 699
T +R+ SV V+ P++D +TCP H W + L C ARG P P
Sbjct: 378 TLEVDGEFLHRNSSVQLRVLYG----PKIDRATCPQHLKWKDKTR-HVLQCQARGNPYPE 432
Query: 700 VRCSREG----IPWPEQQRVSREDAGTYHCVATNAHGTDSRTVTVGVE 743
+RC +EG +P V+ GTY C A+++ G + V + +E
Sbjct: 433 LRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIE 480
>gi|167466198 intercellular adhesion molecule 1 precursor [Homo
sapiens]
Length = 532
Score = 430 bits (1106), Expect = e-120
Identities = 227/451 (50%), Positives = 299/451 (66%), Gaps = 8/451 (1%)
Query: 38 LQPRVAFVERGGSLWLNCSTNCPRPERGGLETSL-RRNGTQRGLRWLARQLVDIREPETQ 96
+ P + RGGS+ + CST+C +P+ G+ET L ++ G +L +++E ++Q
Sbjct: 31 VSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQE-DSQ 89
Query: 97 PVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLT 156
P+C+ C A+ + + P+RVEL PLP WQPVG+N TL C+V G PRA+LT+
Sbjct: 90 PMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVV 149
Query: 157 LLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSS 216
LLRG +EL R GEP A +T TVL RR+ HGANFSCR ELDLRP GL LFEN+S
Sbjct: 150 LLRGEKELKREPAVGEP-----AEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTS 204
Query: 217 APRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVT 276
AP +L+TF L P+L +PR+LEV ++ V C+LDGLFP SEA+V+LALGDQ L+P VT
Sbjct: 205 APYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVT 264
Query: 277 LEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSE 336
D+F A A+ + +AE EG ++L C V LG +++ET + VTIYSFPAP + L++P VSE
Sbjct: 265 YGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSE 324
Query: 337 GQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIK 396
G VTV C A +A VTL GVPA G AQL L AT D+ RSF C ATL+V G+ + K
Sbjct: 325 GTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHK 384
Query: 397 NRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGL 456
N++ ELRVLY PRLD+ DCP +WTWPE +QT C+A GNP P + C + DG L +G
Sbjct: 385 NQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLK-DGTFPLPIGE 443
Query: 457 LGPVTRALSGTYRCKAANDQGEAVKDVTLTV 487
VTR L GTY C+A + QGE + VT+ V
Sbjct: 444 SVTVTRDLEGTYLCRARSTQGEVTRKVTVNV 474
Score = 79.7 bits (195), Expect = 1e-14
Identities = 96/390 (24%), Positives = 149/390 (38%), Gaps = 33/390 (8%)
Query: 213 ENSSAPRELRTFSLSPDAPRLAA-PRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNL 271
+ S + T +P+ LA P VG + C ++G P + V L G++ L
Sbjct: 98 DGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKEL 157
Query: 272 SPDVTLEGDAFVATATATASAEQEGARQLVCNVTLG--------GENRETRENVTIYSFP 323
+ + G+ T T + GA C L EN + + P
Sbjct: 158 KREPAV-GEPAEVTTTVLVRRDHHGAN-FSCRTELDLRPQGLELFENTSAPYQLQTFVLP 215
Query: 324 APLLTLSEPSVSE-GQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFF 382
A L P V E TV C+ V+ V A+ Q +LN T SF
Sbjct: 216 ATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQ----RLNPTVTYGNDSFS 271
Query: 383 CDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWP------------EGPEQTLR 430
A++ V E R +L + +++P EG E T++
Sbjct: 272 AKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVK 331
Query: 431 CEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAAND-QGEAV-KDVT--LT 486
CEA + +++ + A LL ++ C A + G+ + K+ T L
Sbjct: 332 CEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELR 391
Query: 487 VEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAREH 546
V Y P LD CP TW E ++ + C A G P P++ C++ G I + V R+
Sbjct: 392 VLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDL 451
Query: 547 AGTYRCEATNPRGSAAKNVAVTVEYGPRFE 576
GTY C A + +G + V V V PR+E
Sbjct: 452 EGTYLCRARSTQGEVTRKVTVNV-LSPRYE 480
Score = 79.7 bits (195), Expect = 1e-14
Identities = 87/331 (26%), Positives = 130/331 (39%), Gaps = 45/331 (13%)
Query: 363 GQPAQLQLNATENDDRR--SFFCDATLDV--DGETLIKNRSAELRV-----------LYA 407
G+PA++ D +F C LD+ G L +N SA ++ L +
Sbjct: 164 GEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVS 223
Query: 408 PRLDDSD------CPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVT 461
PR+ + D C +P Q P+V A ++ VT
Sbjct: 224 PRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVS----VT 279
Query: 462 RALSGTYRCKAANDQGEAVKDV--TLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGV 519
GT R A G ++ T+T+ PA + + ++ EGTE ++ C AH
Sbjct: 280 AEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVS--EGTEVTVKCEAHPR 337
Query: 520 PPPDVICVRSGELGAVIEGLLRVAREHAG-TYRCEATNPRGSAAKNVAVTVE----YGPR 574
+ V + LG + LL+ E G ++ C AT + T E YGPR
Sbjct: 338 AKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPR 397
Query: 575 FEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRI 634
+E CP NWTW E S + C+ G P P +KC+ G P P + +
Sbjct: 398 LDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDG----------TFPLPIGESVTV 447
Query: 635 PRVLAPGIYVCNATNRHGSVAKTVVVSAESP 665
R L G Y+C A + G V + V V+ SP
Sbjct: 448 TRDL-EGTYLCRARSTQGEVTRKVTVNVLSP 477
Score = 57.4 bits (137), Expect = 6e-08
Identities = 33/95 (34%), Positives = 51/95 (53%), Gaps = 7/95 (7%)
Query: 666 PEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREG---IPWPEQQRVSREDAGT 722
P +DE CP + TW E ++ + + C A G P P ++C ++G +P E V+R+ GT
Sbjct: 396 PRLDERDCPGNWTWPENSQQTPM-CQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGT 454
Query: 723 YHCVATNAHGTDSRTVTVGV---EYRPVVAELAAS 754
Y C A + G +R VTV V Y V+ + A+
Sbjct: 455 YLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAA 489
Score = 35.4 bits (80), Expect = 0.25
Identities = 20/67 (29%), Positives = 34/67 (50%), Gaps = 1/67 (1%)
Query: 810 GEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGE 869
G Y C A + G R++TV V P + + AA++ AGL+ Y+ + K +
Sbjct: 453 GTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVV-AAAVIMGTAGLSTYLYNRQRKIKK 511
Query: 870 YNVQEAE 876
Y +Q+A+
Sbjct: 512 YRLQQAQ 518
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 144 bits (364), Expect = 3e-34
Identities = 185/691 (26%), Positives = 278/691 (40%), Gaps = 91/691 (13%)
Query: 226 LSPDAPRLAAPRLLEVGSERP--VSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFV 283
++P AP ++ + +P VSC++ P R+ L G+ L + +
Sbjct: 423 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPF---RLQLRRGEARLGEERHFQESGNS 479
Query: 284 ATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVT 343
+ AS +EG + V+ G R + + + P L+ +VS G+ ++
Sbjct: 480 SWEILRASKAEEGTYECTA-VSRAGTGR-AKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 537
Query: 344 CAAGAQALVTLEGV------PAAVPGQPAQL-----QLNATENDDRRSFFCDATLDVDGE 392
C +A L V PA+ G+ AQL +++ D + C A+ + +G
Sbjct: 538 CRVLGEAPYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVAS-NANGV 595
Query: 393 TLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGA-- 450
T S L V AP++ S S + +G E + C A G P P + +R
Sbjct: 596 T---RASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE 650
Query: 451 -----VLALG--LLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERIT 503
V A G ++ V +G Y C+A N+ G + VTL P++ +V +
Sbjct: 651 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA 710
Query: 504 WLEGTEASLSCVAHGVPPPDVICVRSGELGAVI------EGLLRV--AREH-AGTYRCEA 554
G EA L C A GVPPP VI R G L ++ G LR+ A+E AGTY C A
Sbjct: 711 --VGEEAVLVCEASGVPPPRVIWYRGG-LEMILAPEGSSSGKLRIPAAQERDAGTYTCRA 767
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
N G A+ + + V + P+ E P + T G L +C G+P P+V G
Sbjct: 768 VNELGDASAEIQLAVGHAPQLTE--LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 825
Query: 615 TEGVLLPLAPPDPSPRAPR--------IPRVLAPGIYVCNATNRHGSVAKT--VVVSAES 664
G+ L S + P AP YVC A N G V ++V+ +
Sbjct: 826 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP--YVCEARNVFGKVQAEARLIVTGHA 883
Query: 665 PPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVS-------- 716
PP++ S+ P+ + LEG S GRP P ++G P P R S
Sbjct: 884 PPQI-ASSAPTVRV-LEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH 941
Query: 717 -----REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRA 771
+E AG Y CVATN G+ R V + V+ P + A G +L C A
Sbjct: 942 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI--TNEGVPASLPCVA 999
Query: 772 EAWPPAQISWRAPPGAL-------NIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
P I+W AL N+ S TL +A G Y C ATN G +
Sbjct: 1000 SGVPAPTITWTKETNALTSRGPHYNV---SKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 1056
Query: 825 RRITVRV----AGPWLWVAVGGAAGGAALLA 851
+ + + V ++W G G+ LA
Sbjct: 1057 QEMRLSVNRLALSKYVWEEYGLLPSGSLRLA 1087
Score = 134 bits (337), Expect = 4e-31
Identities = 152/540 (28%), Positives = 214/540 (39%), Gaps = 69/540 (12%)
Query: 341 TVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSA 400
TVT Q LV + A GQ +L++ + D+ + C + +V GE + R+
Sbjct: 3063 TVTWYKDGQPLVLAQRTQALRGGQ--RLEIQEAQVSDKGLYSCKVS-NVAGEAV---RTF 3116
Query: 401 ELRVLYAPRLDDSDCPRSWTWPE--GPEQTLRCEARGNPEPSV--------------HCA 444
L V P ++ P++ T + G L C+ G P P+V H
Sbjct: 3117 TLTVQVPPTFEN---PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGV 3173
Query: 445 RSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITW 504
S GG L L L P A +GTY C A N Q EA KD + V AP + S G
Sbjct: 3174 VSRGGR-LQLSRLQP---AQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHV 3229
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG---------ELGAVIEG----LLRVAREHAGTYR 551
LEG E L C A G PPPDV ++ G L ++G L + AG Y
Sbjct: 3230 LEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 3289
Query: 552 CEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFS--CEVDGKPQPSVKCV 609
C A NP G A+ V V P ++ + T V G L + C V G P V +
Sbjct: 3290 CVAHNPAGEDARLHTVNVLVPPTIKQ-GADGSGTLVSRPGELVTMVCPVRGSPPIHVSWL 3348
Query: 610 GSGGATEGVLLPLAPP---DPSPRAPRIPRV--LAPGIYVCNATNRHGSVAKTVVVSAES 664
+G+ LPL+ S RI +V GI+ C A + G + + +
Sbjct: 3349 -----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV 3403
Query: 665 PPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQ----------QR 714
PP ++ + + G+ L C ARG P P V ++G P Q +
Sbjct: 3404 PPVLEPVEFQNDVVVVRGSLVE-LPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEA 3462
Query: 715 VSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAW 774
V D+GTY CVA + G R + V P + + + PG L C A+
Sbjct: 3463 VGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGT 3522
Query: 775 PPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
P I+W AL L +N+ V + G Y C A + G + VRV P
Sbjct: 3523 PQPNITWHKDGQALT-RLENNSRATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAP 3579
Score = 128 bits (322), Expect = 2e-29
Identities = 135/546 (24%), Positives = 199/546 (36%), Gaps = 77/546 (14%)
Query: 354 LEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDS 413
L G P + L L + D + C AT +V G T +R A+L V P + +
Sbjct: 1249 LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEV-GST---SRRAKLVVYVPPSIRED 1304
Query: 414 DCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLG--------------- 458
+ + G TL C+A G P P + + + LG G
Sbjct: 1305 GRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 1364
Query: 459 ----------PVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGT 508
+ SG Y C+A N G A +D L V P++ G + + L G
Sbjct: 1365 LDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGA 1424
Query: 509 EASLSCVAHGVPPPDVICVRSGELGAVIEG-----------LLRVAREHA---GTYRCEA 554
+ L C GVP P V + + V+ G +LR+ H G Y+C A
Sbjct: 1425 DVELQCWTSGVPTPQVEWTKDRQ--PVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 1482
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
+P G A++ + V P + +E CE G P P++
Sbjct: 1483 FSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWF----- 1537
Query: 615 TEGVLLPLAPPDPSPRAPR---IPRVLA--PGIYVCNATNRHGSVAKTVVVSAESPPEMD 669
+G LLP + R R + R + G+Y C A+N G+ K + PP ++
Sbjct: 1538 KDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIE 1597
Query: 670 ESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSRE----------- 718
+ + AL C ARG PSP + EG+P E E
Sbjct: 1598 GAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESP 1657
Query: 719 ---DAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRP--GGNFTLTCRAEA 773
+G Y CVA++ G +V V+ P + L A G V G L C+A
Sbjct: 1658 GEASSGLYSCVASSPAGEAVLQYSVEVQVPPQL--LVAEGLGQVTTIVGQPLELPCQASG 1715
Query: 774 WPPAQISW----RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITV 829
P I W R + ++S +TL + H G + C ATN G + V
Sbjct: 1716 SPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEV 1775
Query: 830 RVAGPW 835
V G W
Sbjct: 1776 SVHGEW 1781
Score = 125 bits (315), Expect = 1e-28
Identities = 225/907 (24%), Positives = 330/907 (36%), Gaps = 175/907 (19%)
Query: 51 LWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCAR----R 106
L ++CS + P R L R G +R + +I + C
Sbjct: 444 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAG 503
Query: 107 TLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIR 166
T +A+ I P ++ P P GE LSCRV G P LT +R + L
Sbjct: 504 TGRAKAQIVVTDPPPQLVPAPNVTVSP-GETAVLSCRVLGEAP---YNLTWVRDWRVLP- 558
Query: 167 RSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSL 226
A A+ A L+ + G + C A N++ + L
Sbjct: 559 ---ASTGRVAQLADLSLEISGIIPTDGGRYQCVAS------------NANGVTRASVWLL 603
Query: 227 SPDAPRLA---APRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFV 283
+AP+++ + + G E VSC+ G +P + + Q L D + DA
Sbjct: 604 VREAPQVSIHTSSQHFSQGVEVKVSCSASG-YPTPH--ISWSRESQALQEDSRIHVDAQG 660
Query: 284 ATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVT 343
+ E G C T E +E VT+Y PSVS V V
Sbjct: 661 TLIIQGVAPEDAG--NYSCQAT--NEVGTDQETVTLYY-------TDPPSVSAVNAV-VL 708
Query: 344 CAAGAQALVTLE--GVP---------------AAVPGQPAQLQLNATENDDRRSFFCDAT 386
A G +A++ E GVP A +L++ A + D ++ C A
Sbjct: 709 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV 768
Query: 387 LDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARS 446
++ + +L V +AP+L ++ PR T G L C A G P P+V R
Sbjct: 769 NELGDASA----EIQLAVGHAPQL--TELPRDVTVELGRSALLACRATGRPPPTVTWRRG 822
Query: 447 DG---GAVLALGLLGPVTRALSGT-------------YRCKAANDQGEAVKDVTLTVE-Y 489
DG G L G + SG Y C+A N G+ + L V +
Sbjct: 823 DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH 882
Query: 490 APALDSVGCPERITWLEGTEASLSCVA-HGVPPPDVICVRSGEL-------GAVIEGLL- 540
AP + P + LEG SL C+ G P P+ ++ G +G L
Sbjct: 883 APPQIASSAPT-VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH 941
Query: 541 --RVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEV 598
R +EHAG Y C ATN GS ++V + V+ PR P+ + T EG C
Sbjct: 942 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI-HPTATHHIT-NEGVPASLPCVA 999
Query: 599 DGKPQPSV------KCVGSGG-----ATEGVLLPLAP----------------------- 624
G P P++ + S G + EG LL P
Sbjct: 1000 SGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEM 1059
Query: 625 --------------------PDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAES 664
P S R ++ +V G Y C A+N GS + V+ +
Sbjct: 1060 RLSVNRLALSKYVWEEYGLLPSGSLRLAQV-QVGDSGHYECTASNPAGSASHRYVLGVQV 1118
Query: 665 PPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQ--------QRVS 716
PP++ P L G EA L C A G P P + S++G+ + +
Sbjct: 1119 PPQVQPG--PRVLKVLVG-EALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIR 1175
Query: 717 REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVR---PGGNFTLTCRAEA 773
DAG Y C A+N+ G D+ V + V P A G+ G N +L C A
Sbjct: 1176 TSDAGRYRCEASNSAGVDAWEVELRVLEPP---HWGADETSGLLERVAGENASLPCPARG 1232
Query: 774 WPPAQISWRAPP------GALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRI 827
P Q++WR P G + + S L +A + G+YEC ATN G +RR
Sbjct: 1233 TPKPQVTWRKGPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVGSTSRRA 1291
Query: 828 TVRVAGP 834
+ V P
Sbjct: 1292 KLVVYVP 1298
Score = 123 bits (308), Expect = 9e-28
Identities = 165/656 (25%), Positives = 248/656 (37%), Gaps = 94/656 (14%)
Query: 242 GSERPVSCTLDGLFPASEARVYLALGD---QNLSPDVT--LEGDAFVATATATASAEQEG 296
G E + C DG P A +L G Q++ P + L+G + V + A G
Sbjct: 3232 GQEVRLDCEADGQPPPDVA--WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA---G 3286
Query: 297 ARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSE-GQMVTVTCAAGAQALVTLE 355
A V + G + R NV + S VS G++VT+ C + +
Sbjct: 3287 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 3346
Query: 356 GVPAAVP----------GQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVL 405
+ +P G L+++ + D F C A + +R+ L+V
Sbjct: 3347 WLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG----VADRNFTLQVQ 3402
Query: 406 YAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGL-------LG 458
P L+ + G L CEARG P P V + DG +L+ L L
Sbjct: 3403 VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLEQGPSLQLE 3461
Query: 459 PVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHG 518
V SGTY C A ++ GEA + LTV P ++ G P ++ G L C A G
Sbjct: 3462 AVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQG 3521
Query: 519 VPPPDVICVRSGELGAVIEGLLRVAR----EHAGTYRCEATNPRGSAAKNVAVTVEYGPR 574
P P++ + G+ +E R R AG Y C A +P G+ K+ V V+ P
Sbjct: 3522 TPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPN 3581
Query: 575 FEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRI 634
P P + + C V+ +P P + +G++L P R
Sbjct: 3582 IVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT-----WHRDGIVLQEDAHTQFPERGRF 3636
Query: 635 PRVLA-----PGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALA 689
++ A G Y C A N GS + V + P + S P+ + + + L
Sbjct: 3637 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTI-RSGPPAVNVSVN--QTALLP 3693
Query: 690 CAARGRPSPGVRCSREGIPWPEQ--------------QRVSREDAGTYHCVATNAHGTDS 735
C A G P+P V ++ +P + Q V +DAG Y C+A+N+ G+D
Sbjct: 3694 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 3753
Query: 736 RTVTVGVEYRPVVAELAASPPGGVRPGGNFTLT--------CRAEAWPPAQISW------ 781
+ + V P + A SP N TLT C A P + W
Sbjct: 3754 QGRDLRVLEPPAI---APSP-------SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQK 3803
Query: 782 ---RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
R GA + L SN L+ G S ++EC +N G R V V P
Sbjct: 3804 LDFRLQQGAYRL-LPSNALLLTAPGPQDS--AQFECVVSNEVGEAHRLYQVTVHVP 3856
Score = 118 bits (296), Expect = 2e-26
Identities = 136/467 (29%), Positives = 184/467 (39%), Gaps = 63/467 (13%)
Query: 401 ELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHC--------ARSDGGA-- 450
+LRVL P + S P + T L CEA G+P+P V R GA
Sbjct: 3757 DLRVLEPPAIAPS--PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYR 3814
Query: 451 -----VLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWL 505
L L GP S + C +N+ GEA + +TV P + +T +
Sbjct: 3815 LLPSNALLLTAPGPQD---SAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMM 3871
Query: 506 EGTEASLSCVAHGVPPPDVICVRSG-ELGA-------VIEGLLRVARE---HAGTYRCEA 554
L+C + G+P P V ++G +LGA G L + + HAG Y C A
Sbjct: 3872 --APVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSA 3929
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSG-G 613
N G A K+V +TV+ P + PS V L CE G P+P++ G
Sbjct: 3930 RNSAGVAHKHVFLTVQASPVVK--PLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLN 3987
Query: 614 ATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTC 673
GV + P A P G Y+C A N GS + + PP + E+
Sbjct: 3988 VATGVSTQVLPGGQLRIAHASPE--DAGNYLCIAKNSAGSAMGKTRLVVQVPPVI-ENGL 4044
Query: 674 PSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQ--------------RVSRED 719
P T EG+ A L C ARG P P + ++G P + + +D
Sbjct: 4045 PDLST-TEGSHA-FLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQD 4102
Query: 720 AGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPG--GVRPGGNFTLTCRAEAWPPA 777
AGTY C A NA G R V + + PV L PG +R G L C A P
Sbjct: 4103 AGTYTCTAENAVGRARRRVHLTILVLPVFTTL----PGDRSLRLGDRLWLRCAARGSPTP 4158
Query: 778 QISWRAPPGALNIGLSSNN--STLSVAGAMGSHGGEYECAATNAHGR 822
+I W + G+S + STL A G Y C A N GR
Sbjct: 4159 RIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGR 4205
Score = 113 bits (283), Expect = 7e-25
Identities = 142/562 (25%), Positives = 207/562 (36%), Gaps = 78/562 (13%)
Query: 424 GPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRAL-----SGTYRCKAANDQGE 478
G L C A GNPEP + ++ DG + G G V A +G YRC+A+N G
Sbjct: 1134 GEALDLNCVAEGNPEPQLSWSK-DGVVLQGRGPQGSVHFAAIRTSDAGRYRCEASNSAGV 1192
Query: 479 AVKDVTLTVEYAP---ALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRS------ 529
+V L V P A ++ G ER+ G ASL C A G P P V +
Sbjct: 1193 DAWEVELRVLEPPHWGADETSGLLERVA---GENASLPCPARGTPKPQVTWRKGPSSEPL 1249
Query: 530 -GELGAVI--EG---LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSN 583
G+ G + EG L V+ +G Y C+ATN GS ++ + V P E +N
Sbjct: 1250 HGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKAN 1309
Query: 584 WTWVEGSGRLFSCEVDGKPQPSV------KCVGS--GGATEGVLLP--------LAPPDP 627
+ + G C+ +G P P + + VG G A G L L
Sbjct: 1310 VSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 1369
Query: 628 SPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASA 687
S PRI + G+Y C A N+ G+ + + +PP + + L GA+
Sbjct: 1370 SLHFPRIQEGDS-GLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVE- 1427
Query: 688 LACAARGRPSPGVRCSREGIPW---------PEQQRVSR------EDAGTYHCVATNAHG 732
L C G P+P V +++ P E +V R D G Y CVA + G
Sbjct: 1428 LQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAG 1487
Query: 733 TDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAP----PGAL 788
+R + V P + + V L C A P I+W P +
Sbjct: 1488 QQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTST 1547
Query: 789 NIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAA 848
+ + L + A S G Y C A+NA G + + V P + GA G
Sbjct: 1548 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP---PTIEGAGGRPY 1604
Query: 849 LLAAGAGLAFYVQSTA--------------CKKGEYNVQEAESSGEAVCLNGAGGGAGGA 894
++ A AG ++ A E N E+ G + L G + G
Sbjct: 1605 VVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGL 1664
Query: 895 AGAEGGPEAAGGAAESPAEGEV 916
A + E +V
Sbjct: 1665 YSCVASSPAGEAVLQYSVEVQV 1686
Score = 111 bits (278), Expect = 3e-24
Identities = 159/639 (24%), Positives = 232/639 (36%), Gaps = 111/639 (17%)
Query: 297 ARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEPSVSEGQMVTVTCAAGAQALVTL- 354
A C + E N+ ++ P PL +V EG +++C +
Sbjct: 2136 AGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKIS 2195
Query: 355 ---EGVPAAVPGQPAQLQ----------LNATENDDRRSFFCDATLDVDGETLIKNRSAE 401
+G P +PG+ A LQ L + ++ C+ + +V G + ++ +
Sbjct: 2196 WRKDGQP--LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS-NVVGNS---SQDLQ 2249
Query: 402 LRVLYAPRL-DDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDG---GAVLALGLL 457
L V P++ + P + + TL C A G P P+V R DG GA L L L
Sbjct: 2250 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAELGLQLQ 2308
Query: 458 GP--------VTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCP-ERITWLEGT 508
A +G Y C A N G A + L+V P L P IT +
Sbjct: 2309 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHS 2368
Query: 509 EASLSCVAHGVPPPDVICVRSGE-----------LGAVIEGLLRVAREHAGTYRCEATNP 557
+L C A G+PPP + R E G + + + + +G Y C A+N
Sbjct: 2369 PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE 2428
Query: 558 RGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEG 617
G A +N +V V P E ++G C V G PQP + G
Sbjct: 2429 AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR---- 2484
Query: 618 VLLPLAPPDPSPRAPR--IPRVL-----APGIYVCNATNRHGSVAKTVVVSAESPPEMDE 670
PLA D +P + +VL + G Y C A N G K +S P
Sbjct: 2485 ---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAP---- 2537
Query: 671 STCPSHQTWLEGAEASA-------------LACAARGRPSPGVRCSREGIPWPEQQRVS- 716
T L GAE SA L C A PSP + ++G P+ + +
Sbjct: 2538 -------TILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 2590
Query: 717 -------------REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAE---LAASPPGGVR 760
+EDAG Y CV TN G + V V P +++ L V+
Sbjct: 2591 LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 2650
Query: 761 PGGNFTLTCRAEAW--PPAQISWR------APPGALNIGLSSNNSTLSVAGAMGSHGGEY 812
N TLT E+W PP I W P L + L + S G Y
Sbjct: 2651 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV--LGEGRLLQIQPTQVSDSGRY 2708
Query: 813 ECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLA 851
C ATN G + V + P ++ VG + +L+
Sbjct: 2709 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS 2747
Score = 110 bits (275), Expect = 6e-24
Identities = 156/619 (25%), Positives = 228/619 (36%), Gaps = 68/619 (10%)
Query: 254 LFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGA--RQLVCNVTLGGENR 311
L P S L G + P + + ++ A+ +A ++++G R L +
Sbjct: 3713 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN 3772
Query: 312 ETRENVTIYSFPAPLLTLSEPSV---SEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQL 368
T T P +P V +GQ + GA L+ + PG
Sbjct: 3773 LTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP---- 3828
Query: 369 QLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQT 428
D F C + +V GE +R ++ V P + D +T
Sbjct: 3829 -------QDSAQFECVVSNEV-GEA---HRLYQVTVHVPPTIADDQT--DFTVTMMAPVV 3875
Query: 429 LRCEARGNPEPSVHC--------ARSDGGAVLALGLL--GPVTRALSGTYRCKAANDQGE 478
L C + G P P+V AR G V G L G +G Y C A N G
Sbjct: 3876 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 3935
Query: 479 AVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSG-------E 531
A K V LTV+ +P + + P + + E L C A G+P P + + G
Sbjct: 3936 AHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 3993
Query: 532 LGAVIEGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVE 588
+ G LR+A E AG Y C A N GSA + V+ P E + T E
Sbjct: 3994 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT--E 4051
Query: 589 GSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNAT 648
GS C+ G P+P++ G G + G Y C A
Sbjct: 4052 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE 4111
Query: 649 NRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGV------RC 702
N G + V ++ P +T P ++ L + L CAARG P+P + R
Sbjct: 4112 NAVGRARRRVHLTILVLPVF--TTLPGDRS-LRLGDRLWLRCAARGSPTPRIGWTVNDRP 4168
Query: 703 SREGIPWPE------QQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPP 756
EG+ + + VSRED+GTY C A N G V V+ PV+ A S
Sbjct: 4169 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 4228
Query: 757 GGVRP-GGNFTLTCRAEAWPPAQISW---RAPPGALNIGLSSNNSTLSVAGAMGSHGGEY 812
V P GG+ L C P I W P ++ N +L++ G Y
Sbjct: 4229 --VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRY 4286
Query: 813 ECAATNAHGRHARRITVRV 831
+C A N G A+++ + V
Sbjct: 4287 QCLAENEMG-VAKKVVILV 4304
Score = 107 bits (268), Expect = 4e-23
Identities = 123/491 (25%), Positives = 182/491 (37%), Gaps = 59/491 (12%)
Query: 398 RSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGL- 456
R +LRV P + S+ E L CEARG P P++ + GA+L
Sbjct: 1491 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKD--GALLPTSTK 1548
Query: 457 -----------LGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSV-GCPERITW 504
LG + +G Y CKA+N G A K L V P ++ G P +
Sbjct: 1549 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKA 1608
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG-----------ELGAVIEGLLRVAREHAGTYRCE 553
+ G +L CVA G P P + G E + L +G Y C
Sbjct: 1609 VAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV 1668
Query: 554 ATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGG 613
A++P G A +V V+ P+ T + G C+ G P P+++ + +G
Sbjct: 1669 ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR 1728
Query: 614 ATEGVL-LPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVS--AESPPEMDE 670
E + + +A + + + G++ C ATN G+ V VS E P + E
Sbjct: 1729 PAEELAGVQVASQGTTLHIDHV-ELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLE 1787
Query: 671 STCPSHQTWLEGAEASALAC--------AARGRP-------SPGVRCSRE-------GIP 708
+ E + AC A +P SPG +P
Sbjct: 1788 VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 1847
Query: 709 WPEQ-QRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTL 767
P Q ++V D G Y C ATN G R V + V P + + V + TL
Sbjct: 1848 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNK--AVLENASVTL 1905
Query: 768 TCRAEAWPPAQISW----RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRH 823
C A PP +SW + + + +S + L + A S G Y C A+N G
Sbjct: 1906 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 1965
Query: 824 ARRITVRVAGP 834
R +RV P
Sbjct: 1966 ELRYGLRVNVP 1976
Score = 106 bits (265), Expect = 9e-23
Identities = 145/572 (25%), Positives = 208/572 (36%), Gaps = 82/572 (14%)
Query: 321 SFPAPLLTLSEPSVSEG-------QMVTVTCAAGAQALVTLEGVPAAVP---GQPAQLQL 370
SFPA +P V G +V C+ G+ L G P +P P LQ+
Sbjct: 1802 SFPAAC----DPPVHRGWGAHPKPPLVEGWCSPGS-----LWGEPTGIPVAYSLPPPLQI 1852
Query: 371 NATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLR 430
+ D + C AT ++ GE+ R L+VL P ++ P + E TL
Sbjct: 1853 EKVDLRDEGIYTCAAT-NLAGES---KREVALKVLVPPNIEPG--PVNKAVLENASVTLE 1906
Query: 431 CEARGNPEPSVHCARSDGGAVLALGLL----GPVTR------ALSGTYRCKAANDQGEAV 480
C A G P P V + +G+ G V R + +G+YRC A+N G
Sbjct: 1907 CLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 1966
Query: 481 KDVTLTVEYAPALD-SVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGEL------- 532
L V P + P + L T L+C A G P P ++ ++ G
Sbjct: 1967 LRYGLRVNVPPRITLPPSLPGPV--LVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP 2024
Query: 533 ------GAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTW 586
G + L +G Y C A + G ++V + V P N +
Sbjct: 2025 GLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEEL--NVSV 2082
Query: 587 VEGSGRLFSCEVDGKPQPSVKCVGSGGATE---GVLLPLAPPDPSPRAPRIPRVLAPGIY 643
V C+ P P + G E GV L D + V G Y
Sbjct: 2083 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA---DKALLQVDRADVWDAGHY 2139
Query: 644 VCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCS 703
C A N+ G K ++ P SH + ++L+C RG P P +
Sbjct: 2140 TCEALNQAGHSEKHYNLNVWVAPVFPLRE--SHTLTVREGHPTSLSCECRGVPFPKISWR 2197
Query: 704 REGIPWPEQ----QRVSR------------EDAGTYHCVATNAHGTDSRTVTVGVEYRPV 747
++G P P + Q VS GTY C +N G S+ + + V P
Sbjct: 2198 KDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ 2257
Query: 748 VAELAASPPG-GVRPGGNFTLTCRAEAWPPAQISWRA---PPGA-LNIGLSSNNSTLSVA 802
+A P V G TL C A PP ++W P GA L + L + +L V
Sbjct: 2258 IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVE 2317
Query: 803 GAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
A +H G Y C A N GR R+ + V P
Sbjct: 2318 RAQAAHTGRYSCVAENLAGRAERKFELSVLVP 2349
Score = 104 bits (260), Expect = 3e-22
Identities = 119/463 (25%), Positives = 173/463 (37%), Gaps = 56/463 (12%)
Query: 426 EQTLRCEARGNPEPSVHCARSDGGAVLALGL-----------LGPVTRALSGTYRCKAAN 474
E L CEA G P P++ + G +A G+ + + +G Y C A N
Sbjct: 3964 EVLLPCEASGIPRPTITWQKE--GLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 4021
Query: 475 DQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGA 534
G A+ L V+ P +++ G P+ T EG+ A L C A G P P++ + G+ +
Sbjct: 4022 SAGSAMGKTRLVVQVPPVIEN-GLPDLST-TEGSHAFLPCKARGSPEPNITWDKDGQPVS 4079
Query: 535 VIEGLLRVAR-----------EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSN 583
EG + + AGTY C A N G A + V +T+ P F + P +
Sbjct: 4080 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFT--TLPGD 4137
Query: 584 WTWVEGSGRLFSCEVDGKPQPSVK-CVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAP-G 641
+ G C G P P + V TEGV + D R G
Sbjct: 4138 RSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV----SEQDGGSTLQRAAVSREDSG 4193
Query: 642 IYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVR 701
YVC A NR G V + P + + S+ G L C RG P P +
Sbjct: 4194 TYVCWAENRVGRTQAVSFVHVKEAPVL-QGEAFSYLVEPVGGSIQ-LDCVVRGDPVPDIH 4251
Query: 702 CSREGIPWPEQQ-------------RVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVV 748
++G+P R R+DAG Y C+A N G + V + ++ PV
Sbjct: 4252 WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 4311
Query: 749 AELAASPPGGVRPGGNFTLTCRAEAWPPAQISW---RAPPGALNIGLSSNNSTLSVAGAM 805
VR G + L C+A P I W P A + + +L +
Sbjct: 4312 Q--VEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVE 4369
Query: 806 GSHGGEYECAATNAHGRHARR--ITVRVAGPWLWVAVGGAAGG 846
G Y+C A N G R + VR W ++ G G
Sbjct: 4370 TGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVING 4412
Score = 103 bits (257), Expect = 7e-22
Identities = 115/427 (26%), Positives = 156/427 (36%), Gaps = 70/427 (16%)
Query: 465 SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPD- 523
SG Y C A+N G A L V+ P + P + L G L+CVA G P P
Sbjct: 1094 SGHYECTASNPAGSASHRYVLGVQVPPQVQPG--PRVLKVLVGEALDLNCVAEGNPEPQL 1151
Query: 524 ------VICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEE 577
V+ G G+V +R + AG YRCEA+N G A V + V P +
Sbjct: 1152 SWSKDGVVLQGRGPQGSVHFAAIRTS--DAGRYRCEASNSAGVDAWEVELRVLEPPHWGA 1209
Query: 578 PSCPSNWTWVEGSGRLFSCEVDGKPQPSVKC------------VGSGGATEGVLLPLAPP 625
V G C G P+P V G EG L LA
Sbjct: 1210 DETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLF-LASV 1268
Query: 626 DPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEA 685
P+ G Y C ATN GS ++ + PP + E ++ + + G ++
Sbjct: 1269 SPADS----------GDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAG-QS 1317
Query: 686 SALACAARGRPSP-----------GVRCSREGIPWP-------------EQQ-----RVS 716
L C A G P P GV G W E Q R+
Sbjct: 1318 LTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ 1377
Query: 717 REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPP 776
D+G Y C A N GT R + V P V A+ G + L C P
Sbjct: 1378 EGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPT 1437
Query: 777 AQISW---RAP--PGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRV 831
Q+ W R P PG ++ + + L + G+ G Y+C A + G+ AR +RV
Sbjct: 1438 PQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV 1497
Query: 832 -AGPWLW 837
A P +W
Sbjct: 1498 HAPPTIW 1504
Score = 100 bits (250), Expect = 5e-21
Identities = 142/610 (23%), Positives = 223/610 (36%), Gaps = 84/610 (13%)
Query: 290 ASAEQEGARQLVCNVTLGGENRETRENVTIY-SFPAPLLTLSEPSVSEGQMVTVTCAAGA 348
A QEG C+ +G +++ + V + P ++ SV + + T+ C A
Sbjct: 2225 AQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATG 2284
Query: 349 QALVTL----EGVPAA------VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNR 398
+ T+ +G P + Q L + + + C A ++ G R
Sbjct: 2285 KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRA---ER 2340
Query: 399 SAELRVLYAPRL-DDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGA------- 450
EL VL P L D D + T TL CEA G P P++ R +
Sbjct: 2341 KFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 2400
Query: 451 VLALGLLGPVTRAL---SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEG 507
+LA G + +T+ SG Y C A+N+ GEA ++ ++ V P++++ E I L+G
Sbjct: 2401 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG 2460
Query: 508 TEASLSCVAHGVPPPDVICVRSGELGA-----------VIEGLLRVAREHAGTYRCEATN 556
A L C G P P + + G A V+ +L+ AG Y C A N
Sbjct: 2461 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 2520
Query: 557 PRGSAAKNVAVTVEYGPRF---EEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGG 613
G K+ ++V P E S T + CE P P++ + G
Sbjct: 2521 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 2580
Query: 614 ATEGVL-LPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDEST 672
E + L P + + A G Y C TN G K V PP + +
Sbjct: 2581 PFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLIPPSISKDD 2639
Query: 673 CPSHQTWLEGAEAS-----ALACAARGRPSPGVRCSREGIPWPEQQRV------------ 715
P + ++ + L C + P P +R ++G P R+
Sbjct: 2640 -PLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ 2698
Query: 716 --SREDAGTYHCVATNAHGTDSRTVTVGVEYRPV---VAELAAS---------PPGGVRP 761
D+G Y CVATN G D + V ++ P+ V + +A+ GGV
Sbjct: 2699 PTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTE 2758
Query: 762 GGNFT------LTCRAEAWPPAQISWRAPPGALNIG----LSSNNSTLSVAGAMGSHGGE 811
L C A PP ++W L+ G + L + + G
Sbjct: 2759 YREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR 2818
Query: 812 YECAATNAHG 821
Y C A+N G
Sbjct: 2819 YSCKASNEVG 2828
Score = 93.2 bits (230), Expect = 1e-18
Identities = 128/544 (23%), Positives = 194/544 (35%), Gaps = 94/544 (17%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
LQ+ + +D + C T ++ GE +KN E VL P + D E +
Sbjct: 2597 LQILNAQKEDAGQYTCVVTNEL-GEA-VKNYHVE--VLIPPSISKDDPLGEVGVKEVKTK 2652
Query: 428 -----TLRCEARGNPEPSVHCARSDGGAVLA---LGLLG--------PVTRALSGTYRCK 471
TL CE+ P P++ + DG V L +LG P + SG Y C
Sbjct: 2653 VNSTLTLECESWAVPPPTIRWYK-DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 2711
Query: 472 AANDQGEAVKDVTLTVEYAPALDSVG------------------CPERITWLEGTEASLS 513
A N GE +D + ++ P VG E +E A L
Sbjct: 2712 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 2771
Query: 514 CVAHGVPPPDVICVR------SGELGAVIEG-----LLRVAREHAGTYRCEATNPRGSAA 562
C + +PPPD+ R +G+ +V++G + V E+AG Y C+A+N G
Sbjct: 2772 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDW 2831
Query: 563 KNVAVTVEYGPRF--EEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLL 620
+ + V P + T S C G P P++ + +G
Sbjct: 2832 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-------- 2883
Query: 621 PLAPPDPSPRAPRIP----------RVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDE 670
P PSPR + V Y+C A N+ GS K + + PP +
Sbjct: 2884 --LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG 2941
Query: 671 STCPSHQTWLEGAEASALACAARGRPSPGVRCSREG-----------IPWPEQQRVSR-- 717
L + + L C P+P V ++ +P ++ R
Sbjct: 2942 LDLEQVTAILNSSVS--LPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRAR 2999
Query: 718 -EDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGG--VRPGGNFTLTCRAEAW 774
D+G Y C A NA G D + V + V P + P VR G L+C +A
Sbjct: 3000 LSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 3059
Query: 775 PPAQISWRAPPGALNIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVR 830
P ++W L + + L + A S G Y C +N G R T+
Sbjct: 3060 PEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLT 3119
Query: 831 VAGP 834
V P
Sbjct: 3120 VQVP 3123
Score = 90.5 bits (223), Expect = 6e-18
Identities = 183/806 (22%), Positives = 276/806 (34%), Gaps = 143/806 (17%)
Query: 134 VGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHG 193
VGE L C G P + RG E+I + R + A +E
Sbjct: 711 VGEEAVLVCEASGVPPPRVIWY---RGGLEMILAPEGSSSGKLR-------IPAAQERDA 760
Query: 194 ANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDG 253
++CRA +L ++SA +L +P L +E+G ++C G
Sbjct: 761 GTYTCRAVNELG--------DASAEIQLAV-GHAPQLTELPRDVTVELGRSALLACRATG 811
Query: 254 LFPASEA-----------RVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVC 302
P + R+ G ++ PD G F S E VC
Sbjct: 812 RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD---SGVLFFE------SVAPEDQAPYVC 862
Query: 303 NV--TLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVT-----LE 355
G E R VT ++ P + V EGQ V++ C A + +
Sbjct: 863 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 922
Query: 356 GVPAAVPGQPAQLQLNATENDDRR------SFFCDATLDVDGETLIKNRSAELRVLYAPR 409
G P PG ++ + + + DR + C AT + +R EL V PR
Sbjct: 923 GRPLP-PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ----HRDVELVVQVPPR 977
Query: 410 LDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALG-----------LLG 458
+ + EG +L C A G P P++ + + A+ + G L+
Sbjct: 978 IHPTATHHITN--EGVPASLPCVASGVPAPTITWTK-ETNALTSRGPHYNVSKEGTLLIA 1034
Query: 459 PVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHG 518
+ +G Y C A N G + +++ L+V + W E +G
Sbjct: 1035 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLAL-------SKYVWEE----------YG 1077
Query: 519 VPPPDVICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEP 578
+ P SG L L +V +G Y C A+NP GSA+ + V+ P+ +
Sbjct: 1078 LLP-------SGSLR-----LAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPG 1125
Query: 579 SCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVL 638
P + G +C +G P+P + + +GV+L P S I R
Sbjct: 1126 --PRVLKVLVGEALDLNCVAEGNPEPQL-----SWSKDGVVLQGRGPQGSVHFAAI-RTS 1177
Query: 639 APGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSP 698
G Y C A+N G A V + PP + G AS L C ARG P P
Sbjct: 1178 DAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENAS-LPCPARGTPKP 1236
Query: 699 GVRC----------SREGIPWPEQ-----QRVSREDAGTYHCVATNAHGTDSRTVTVGVE 743
V + G+ E+ VS D+G Y C ATN G+ SR + V
Sbjct: 1237 QVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVY 1296
Query: 744 YRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVA- 802
P + E G + TL C A +P +I W + + L +
Sbjct: 1297 VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 1356
Query: 803 GAMGSH------------------GGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAA 844
G +G H G Y C A N G R + V P + G A
Sbjct: 1357 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ 1416
Query: 845 GGAALLAAGAGLAFYVQSTACKKGEY 870
L A L + + E+
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEW 1442
Score = 35.8 bits (81), Expect = 0.19
Identities = 68/295 (23%), Positives = 103/295 (34%), Gaps = 45/295 (15%)
Query: 223 TFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAF 282
T + P L R L +G + C G + R+ + D+ ++ V+ E D
Sbjct: 4124 TILVLPVFTTLPGDRSLRLGDRLWLRCAARG---SPTPRIGWTVNDRPVTEGVS-EQDGG 4179
Query: 283 VATATATASAEQEGARQLVCNVTLGGENRETRENVT--IYSFPAPLLT------LSEPSV 334
A S E G VC ENR R ++ AP+L L EP
Sbjct: 4180 STLQRAAVSREDSGT--YVC----WAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV- 4232
Query: 335 SEGQMVTVTCAAGAQALVTLEGVPAAVPG---------QPAQLQLNATENDDRRSFFCDA 385
G + + C + + + +P Q L ++ TE DD + C A
Sbjct: 4233 --GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLA 4290
Query: 386 TLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCAR 445
+ E + + L + AP P+ T G + LRC+A G P P++ +
Sbjct: 4291 ----ENEMGVAKKVVILVLQSAPVFQVE--PQDMTVRSGDDVALRCQATGEPTPTIEWLQ 4344
Query: 446 SDGGAVLALGL---------LGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAP 491
+ + L L V +GTY C A N G A L V P
Sbjct: 4345 AGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 142 bits (359), Expect = 1e-33
Identities = 180/667 (26%), Positives = 270/667 (40%), Gaps = 87/667 (13%)
Query: 226 LSPDAPRLAAPRLLEVGSERP--VSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFV 283
++P AP ++ + +P VSC++ P R+ L G+ L + +
Sbjct: 306 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPF---RLQLRRGEARLGEERHFQESGNS 362
Query: 284 ATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVT 343
+ AS +EG + V+ G R + + + P L+ +VS G+ ++
Sbjct: 363 SWEILRASKAEEGTYECTA-VSRAGTGR-AKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 420
Query: 344 CAAGAQALVTLEGV------PAAVPGQPAQL-----QLNATENDDRRSFFCDATLDVDGE 392
C +A L V PA+ G+ AQL +++ D + C A+ + +G
Sbjct: 421 CRVLGEAPYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVAS-NANGV 478
Query: 393 TLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGA-- 450
T S L V AP++ S S + +G E + C A G P P + +R
Sbjct: 479 T---RASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE 533
Query: 451 -----VLALG--LLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERIT 503
V A G ++ V +G Y C+A N+ G + VTL P++ +V +
Sbjct: 534 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA 593
Query: 504 WLEGTEASLSCVAHGVPPPDVICVRSGELGAVI------EGLLRV--AREH-AGTYRCEA 554
G EA L C A GVPPP VI R G L ++ G LR+ A+E AGTY C A
Sbjct: 594 --VGEEAVLVCEASGVPPPRVIWYRGG-LEMILAPEGSSSGKLRIPAAQERDAGTYTCRA 650
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
N G A+ + + V + P+ E P + T G L +C G+P P+V G
Sbjct: 651 VNELGDASAEIQLAVGHAPQLTE--LPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
Query: 615 TEGVLLPLAPPDPSPRAPR--------IPRVLAPGIYVCNATNRHGSVAKT--VVVSAES 664
G+ L S + P AP YVC A N G V ++V+ +
Sbjct: 709 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAP--YVCEARNVFGKVQAEARLIVTGHA 766
Query: 665 PPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVS-------- 716
PP++ S+ P+ + LEG S GRP P ++G P P R S
Sbjct: 767 PPQI-ASSAPTVRV-LEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH 824
Query: 717 -----REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRA 771
+E AG Y CVATN G+ R V + V+ P + A G +L C A
Sbjct: 825 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHI--TNEGVPASLPCVA 882
Query: 772 EAWPPAQISWRAPPGAL-------NIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
P I+W AL N+ S TL +A G Y C ATN G +
Sbjct: 883 SGVPAPTITWTKETNALTSRGPHYNV---SKEGTLLIAQPSAQDAGAYVCTATNTVGFSS 939
Query: 825 RRITVRV 831
+ + + V
Sbjct: 940 QEMRLSV 946
Score = 120 bits (302), Expect = 4e-27
Identities = 169/602 (28%), Positives = 234/602 (38%), Gaps = 101/602 (16%)
Query: 310 NRETRENVTIYSFPAPLLTL--SEPSVSEGQMVTVTCAAG------------AQALVTLE 355
N TR +V + AP +++ S S+G V V+C+A +QAL
Sbjct: 476 NGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDS 535
Query: 356 GVPAAVPGQPAQLQLNATENDDRRSFFCDATLDV--DGETLIKNRSAELRVLYAPRLDDS 413
+ G L + +D ++ C AT +V D ET+ + Y S
Sbjct: 536 RIHVDAQGT---LIIQGVAPEDAGNYSCQATNEVGTDQETVT--------LYYTDPPSVS 584
Query: 414 DCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRAL--------- 464
G E L CEA G P P V R GG + L G + L
Sbjct: 585 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERD 642
Query: 465 SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDV 524
+GTY C+A N+ G+A ++ L V +AP L + P +T G A L+C A G PPP V
Sbjct: 643 AGTYTCRAVNELGDASAEIQLAVGHAPQLTEL--PRDVTVELGRSALLACRATGRPPPTV 700
Query: 525 ICVRSG------ELGA--------VIEGLL---RVAREHAGTYRCEATNPRGSAAKNVAV 567
R LGA G+L VA E Y CEA N G +
Sbjct: 701 TWRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARL 760
Query: 568 TVE-YGPRFEEPSCPSNWTWVEGSGRLFSCEV-DGKPQPSVKCVGSGGATEGVLLPLAPP 625
V + P S P+ +EG C V G+P P + G PL P
Sbjct: 761 IVTGHAPPQIASSAPTVRV-LEGQPVSLPCIVLAGRPLPERHWLKDGR-------PLPPG 812
Query: 626 DP-SPRAP---RIPRVLAP--GIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTW 679
S RA + R L G Y C ATN GS + V + + PP + + +H
Sbjct: 813 SRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTA--THHIT 870
Query: 680 LEGAEASALACAARGRPSPGVRCSREGIPWPEQ--------------QRVSREDAGTYHC 725
EG AS L C A G P+P + ++E + + S +DAG Y C
Sbjct: 871 NEGVPAS-LPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVC 929
Query: 726 VATNAHGTDSRTVTVGVEYRPVV---AELAASPPGGV--RPGGNFTLTCRAEAWPPAQIS 780
ATN G S+ + + V +P + A+ P V + G TL C A+ PP ++
Sbjct: 930 TATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPPPLVT 989
Query: 781 WR-----APPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPW 835
W PP GL + S L +A G YEC A+N G + R + V G
Sbjct: 990 WTKDSRPVPPITNRYGLLPSGS-LRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRT 1048
Query: 836 LW 837
W
Sbjct: 1049 SW 1050
Score = 107 bits (268), Expect = 4e-23
Identities = 194/777 (24%), Positives = 288/777 (37%), Gaps = 138/777 (17%)
Query: 51 LWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCAR----R 106
L ++CS + P R L R G +R + +I + C
Sbjct: 327 LLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAG 386
Query: 107 TLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIR 166
T +A+ I P ++ P P GE LSCRV G P LT +R + L
Sbjct: 387 TGRAKAQIVVTDPPPQLVPAPNVTVSP-GETAVLSCRVLGEAP---YNLTWVRDWRVLP- 441
Query: 167 RSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSL 226
A A+ A L+ + G + C A N++ + L
Sbjct: 442 ---ASTGRVAQLADLSLEISGIIPTDGGRYQCVAS------------NANGVTRASVWLL 486
Query: 227 SPDAPRLA---APRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFV 283
+AP+++ + + G E VSC+ G +P + + Q L D + DA
Sbjct: 487 VREAPQVSIHTSSQHFSQGVEVKVSCSASG-YPTPH--ISWSRESQALQEDSRIHVDAQG 543
Query: 284 ATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVT 343
+ E G C T E +E VT+Y PSVS V V
Sbjct: 544 TLIIQGVAPEDAG--NYSCQAT--NEVGTDQETVTLYY-------TDPPSVSAVNAV-VL 591
Query: 344 CAAGAQALVTLE--GVP---------------AAVPGQPAQLQLNATENDDRRSFFCDAT 386
A G +A++ E GVP A +L++ A + D ++ C A
Sbjct: 592 VAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV 651
Query: 387 LDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARS 446
++ + +L V +AP+L ++ PR T G L C A G P P+V R
Sbjct: 652 NELGDASA----EIQLAVGHAPQL--TELPRDVTVELGRSALLACRATGRPPPTVTWRRG 705
Query: 447 DG---GAVLALGLLGPVTRALSGT-------------YRCKAANDQGEAVKDVTLTVE-Y 489
DG G L G + SG Y C+A N G+ + L V +
Sbjct: 706 DGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGH 765
Query: 490 APALDSVGCPERITWLEGTEASLSCVA-HGVPPPDVICVRSGEL-------GAVIEGLL- 540
AP + P + LEG SL C+ G P P+ ++ G +G L
Sbjct: 766 APPQIASSAPT-VRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLH 824
Query: 541 --RVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEV 598
R +EHAG Y C ATN GS ++V + V+ PR P+ + T EG C
Sbjct: 825 LDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRI-HPTATHHIT-NEGVPASLPCVA 882
Query: 599 DGKPQPSV------KCVGSGG-----ATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNA 647
G P P++ + S G + EG LL +A P G YVC A
Sbjct: 883 SGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQD----------AGAYVCTA 931
Query: 648 TNRHGSVAKTVVVSAESPPEMD-----ESTCPSHQTWLEGAEASALACAARGRPSPGVRC 702
TN G ++ + +S + P + + P T G E + L C A+G P P V
Sbjct: 932 TNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVT-LDCEAKGSPPPLVTW 990
Query: 703 SREGIPWP--------------EQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYR 745
+++ P P +V D+G Y C A+N G+ S +GV+ R
Sbjct: 991 TKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGR 1047
Score = 74.3 bits (181), Expect = 5e-13
Identities = 78/283 (27%), Positives = 107/283 (37%), Gaps = 27/283 (9%)
Query: 425 PEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVT 484
PE+ + R P S H R+DG L L + +G Y C A N G +DV
Sbjct: 798 PERHWLKDGRPLPPGSRHSIRADGSLHLDRAL-----QEHAGRYSCVATNTAGSQHRDVE 852
Query: 485 LTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDV--------ICVRSGELGAVI 536
L V+ P + IT EG ASL CVA GVP P + + R
Sbjct: 853 LVVQVPPRIHPTAT-HHIT-NEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSK 910
Query: 537 EGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFE-----EPSCPSNWTWVE 588
EG L +A+ + AG Y C ATN G +++ + ++V PR + P T
Sbjct: 911 EGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKA 970
Query: 589 GSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAP-PDPSPRAPRIPRVLAPGIYVCNA 647
G CE G P P V + P S R ++ +V G Y C A
Sbjct: 971 GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQV-QVGDSGHYECTA 1029
Query: 648 TNRHGSVAKTVVVSAESPPEMDEST--CPSHQTWLEGAEASAL 688
+N GS + V+ + + P H L G L
Sbjct: 1030 SNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSVPLL 1072
Score = 67.4 bits (163), Expect = 6e-11
Identities = 116/499 (23%), Positives = 183/499 (36%), Gaps = 87/499 (17%)
Query: 134 VGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHG 193
VGE L C G P + RG E+I + R + A +E
Sbjct: 594 VGEEAVLVCEASGVPPPRVIWY---RGGLEMILAPEGSSSGKLR-------IPAAQERDA 643
Query: 194 ANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPRLLEVGSERPVSCTLDG 253
++CRA +L ++SA +L +P L +E+G ++C G
Sbjct: 644 GTYTCRAVNELG--------DASAEIQLAV-GHAPQLTELPRDVTVELGRSALLACRATG 694
Query: 254 LFPASEA-----------RVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVC 302
P + R+ G ++ PD G F S E VC
Sbjct: 695 RPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPD---SGVLFFE------SVAPEDQAPYVC 745
Query: 303 NV--TLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVT-----LE 355
G E R VT ++ P + V EGQ V++ C A + +
Sbjct: 746 EARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 805
Query: 356 GVPAAVPGQPAQLQLNATENDDRR------SFFCDATLDVDGETLIKNRSAELRVLYAPR 409
G P PG ++ + + + DR + C AT + +R EL V PR
Sbjct: 806 GRPLP-PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQ----HRDVELVVQVPPR 860
Query: 410 LDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALG-----------LLG 458
+ + EG +L C A G P P++ + + A+ + G L+
Sbjct: 861 IHPTATHHITN--EGVPASLPCVASGVPAPTITWTK-ETNALTSRGPHYNVSKEGTLLIA 917
Query: 459 PVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGC-----PERITWLEGTEASLS 513
+ +G Y C A N G + +++ L+V P + G P ++T G E +L
Sbjct: 918 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLD 977
Query: 514 CVAHGVPPPDVICVR--------SGELGAVIEGLLRVAREHAGT---YRCEATNPRGSAA 562
C A G PPP V + + G + G LR+A+ G Y C A+NP GSA+
Sbjct: 978 CEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSAS 1037
Query: 563 KNVAVTVEYGPRFEEPSCP 581
+ V+ ++ S P
Sbjct: 1038 HRYVLGVQGRTSWQPQSLP 1056
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 134 bits (337), Expect = 4e-31
Identities = 152/540 (28%), Positives = 214/540 (39%), Gaps = 69/540 (12%)
Query: 341 TVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSA 400
TVT Q LV + A GQ +L++ + D+ + C + +V GE + R+
Sbjct: 1872 TVTWYKDGQPLVLAQRTQALRGGQ--RLEIQEAQVSDKGLYSCKVS-NVAGEAV---RTF 1925
Query: 401 ELRVLYAPRLDDSDCPRSWTWPE--GPEQTLRCEARGNPEPSV--------------HCA 444
L V P ++ P++ T + G L C+ G P P+V H
Sbjct: 1926 TLTVQVPPTFEN---PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGV 1982
Query: 445 RSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITW 504
S GG L L L P A +GTY C A N Q EA KD + V AP + S G
Sbjct: 1983 VSRGGR-LQLSRLQP---AQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHV 2038
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG---------ELGAVIEG----LLRVAREHAGTYR 551
LEG E L C A G PPPDV ++ G L ++G L + AG Y
Sbjct: 2039 LEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 2098
Query: 552 CEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFS--CEVDGKPQPSVKCV 609
C A NP G A+ V V P ++ + T V G L + C V G P V +
Sbjct: 2099 CVAHNPAGEDARLHTVNVLVPPTIKQ-GADGSGTLVSRPGELVTMVCPVRGSPPIHVSWL 2157
Query: 610 GSGGATEGVLLPLAPP---DPSPRAPRIPRV--LAPGIYVCNATNRHGSVAKTVVVSAES 664
+G+ LPL+ S RI +V GI+ C A + G + + +
Sbjct: 2158 -----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV 2212
Query: 665 PPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQ----------QR 714
PP ++ + + G+ L C ARG P P V ++G P Q +
Sbjct: 2213 PPVLEPVEFQNDVVVVRGSLVE-LPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEA 2271
Query: 715 VSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAW 774
V D+GTY CVA + G R + V P + + + PG L C A+
Sbjct: 2272 VGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGT 2331
Query: 775 PPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
P I+W AL L +N+ V + G Y C A + G + VRV P
Sbjct: 2332 PQPNITWHKDGQALT-RLENNSRATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAP 2388
Score = 123 bits (308), Expect = 9e-28
Identities = 165/656 (25%), Positives = 248/656 (37%), Gaps = 94/656 (14%)
Query: 242 GSERPVSCTLDGLFPASEARVYLALGD---QNLSPDVT--LEGDAFVATATATASAEQEG 296
G E + C DG P A +L G Q++ P + L+G + V + A G
Sbjct: 2041 GQEVRLDCEADGQPPPDVA--WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA---G 2095
Query: 297 ARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSE-GQMVTVTCAAGAQALVTLE 355
A V + G + R NV + S VS G++VT+ C + +
Sbjct: 2096 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 2155
Query: 356 GVPAAVP----------GQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVL 405
+ +P G L+++ + D F C A + +R+ L+V
Sbjct: 2156 WLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG----VADRNFTLQVQ 2211
Query: 406 YAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGL-------LG 458
P L+ + G L CEARG P P V + DG +L+ L L
Sbjct: 2212 VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLEQGPSLQLE 2270
Query: 459 PVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHG 518
V SGTY C A ++ GEA + LTV P ++ G P ++ G L C A G
Sbjct: 2271 AVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQG 2330
Query: 519 VPPPDVICVRSGELGAVIEGLLRVAR----EHAGTYRCEATNPRGSAAKNVAVTVEYGPR 574
P P++ + G+ +E R R AG Y C A +P G+ K+ V V+ P
Sbjct: 2331 TPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPN 2390
Query: 575 FEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRI 634
P P + + C V+ +P P + +G++L P R
Sbjct: 2391 IVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT-----WHRDGIVLQEDAHTQFPERGRF 2445
Query: 635 PRVLA-----PGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALA 689
++ A G Y C A N GS + V + P + S P+ + + + L
Sbjct: 2446 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTI-RSGPPAVNVSVN--QTALLP 2502
Query: 690 CAARGRPSPGVRCSREGIPWPEQ--------------QRVSREDAGTYHCVATNAHGTDS 735
C A G P+P V ++ +P + Q V +DAG Y C+A+N+ G+D
Sbjct: 2503 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 2562
Query: 736 RTVTVGVEYRPVVAELAASPPGGVRPGGNFTLT--------CRAEAWPPAQISW------ 781
+ + V P + A SP N TLT C A P + W
Sbjct: 2563 QGRDLRVLEPPAI---APSP-------SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQK 2612
Query: 782 ---RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
R GA + L SN L+ G S ++EC +N G R V V P
Sbjct: 2613 LDFRLQQGAYRL-LPSNALLLTAPGPQDS--AQFECVVSNEVGEAHRLYQVTVHVP 2665
Score = 118 bits (296), Expect = 2e-26
Identities = 136/467 (29%), Positives = 184/467 (39%), Gaps = 63/467 (13%)
Query: 401 ELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHC--------ARSDGGA-- 450
+LRVL P + S P + T L CEA G+P+P V R GA
Sbjct: 2566 DLRVLEPPAIAPS--PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYR 2623
Query: 451 -----VLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWL 505
L L GP S + C +N+ GEA + +TV P + +T +
Sbjct: 2624 LLPSNALLLTAPGPQD---SAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMM 2680
Query: 506 EGTEASLSCVAHGVPPPDVICVRSG-ELGA-------VIEGLLRVARE---HAGTYRCEA 554
L+C + G+P P V ++G +LGA G L + + HAG Y C A
Sbjct: 2681 --APVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSA 2738
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSG-G 613
N G A K+V +TV+ P + PS V L CE G P+P++ G
Sbjct: 2739 RNSAGVAHKHVFLTVQASPVVK--PLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLN 2796
Query: 614 ATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTC 673
GV + P A P G Y+C A N GS + + PP + E+
Sbjct: 2797 VATGVSTQVLPGGQLRIAHASPE--DAGNYLCIAKNSAGSAMGKTRLVVQVPPVI-ENGL 2853
Query: 674 PSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQ--------------RVSRED 719
P T EG+ A L C ARG P P + ++G P + + +D
Sbjct: 2854 PDLST-TEGSHA-FLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQD 2911
Query: 720 AGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPG--GVRPGGNFTLTCRAEAWPPA 777
AGTY C A NA G R V + + PV L PG +R G L C A P
Sbjct: 2912 AGTYTCTAENAVGRARRRVHLTILVLPVFTTL----PGDRSLRLGDRLWLRCAARGSPTP 2967
Query: 778 QISWRAPPGALNIGLSSNN--STLSVAGAMGSHGGEYECAATNAHGR 822
+I W + G+S + STL A G Y C A N GR
Sbjct: 2968 RIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGR 3014
Score = 111 bits (277), Expect = 4e-24
Identities = 159/639 (24%), Positives = 231/639 (36%), Gaps = 111/639 (17%)
Query: 297 ARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEPSVSEGQMVTVTCAAGAQALVTL- 354
A C E N+ ++ P PL +V EG +++C +
Sbjct: 945 AGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKIS 1004
Query: 355 ---EGVPAAVPGQPAQLQ----------LNATENDDRRSFFCDATLDVDGETLIKNRSAE 401
+G P +PG+ A LQ L + ++ C+ + +V G + ++ +
Sbjct: 1005 WRKDGQP--LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS-NVVGNS---SQDLQ 1058
Query: 402 LRVLYAPRL-DDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDG---GAVLALGLL 457
L V P++ + P + + TL C A G P P+V R DG GA L L L
Sbjct: 1059 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAELGLQLQ 1117
Query: 458 GP--------VTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCP-ERITWLEGT 508
A +G Y C A N G A + L+V P L P IT +
Sbjct: 1118 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHS 1177
Query: 509 EASLSCVAHGVPPPDVICVRSGE-----------LGAVIEGLLRVAREHAGTYRCEATNP 557
+L C A G+PPP + R E G + + + + +G Y C A+N
Sbjct: 1178 PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE 1237
Query: 558 RGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEG 617
G A +N +V V P E ++G C V G PQP + G
Sbjct: 1238 AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR---- 1293
Query: 618 VLLPLAPPDPSPRAPR--IPRVL-----APGIYVCNATNRHGSVAKTVVVSAESPPEMDE 670
PLA D +P + +VL + G Y C A N G K +S P
Sbjct: 1294 ---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAP---- 1346
Query: 671 STCPSHQTWLEGAEASA-------------LACAARGRPSPGVRCSREGIPWPEQQRVS- 716
T L GAE SA L C A PSP + ++G P+ + +
Sbjct: 1347 -------TILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 1399
Query: 717 -------------REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAE---LAASPPGGVR 760
+EDAG Y CV TN G + V V P +++ L V+
Sbjct: 1400 LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVK 1459
Query: 761 PGGNFTLTCRAEAW--PPAQISWR------APPGALNIGLSSNNSTLSVAGAMGSHGGEY 812
N TLT E+W PP I W P L + L + S G Y
Sbjct: 1460 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV--LGEGRLLQIQPTQVSDSGRY 1517
Query: 813 ECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLA 851
C ATN G + V + P ++ VG + +L+
Sbjct: 1518 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS 1556
Score = 110 bits (275), Expect = 6e-24
Identities = 156/619 (25%), Positives = 228/619 (36%), Gaps = 68/619 (10%)
Query: 254 LFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGA--RQLVCNVTLGGENR 311
L P S L G + P + + ++ A+ +A ++++G R L +
Sbjct: 2522 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN 2581
Query: 312 ETRENVTIYSFPAPLLTLSEPSV---SEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQL 368
T T P +P V +GQ + GA L+ + PG
Sbjct: 2582 LTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP---- 2637
Query: 369 QLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQT 428
D F C + +V GE +R ++ V P + D +T
Sbjct: 2638 -------QDSAQFECVVSNEV-GEA---HRLYQVTVHVPPTIADDQT--DFTVTMMAPVV 2684
Query: 429 LRCEARGNPEPSVHC--------ARSDGGAVLALGLL--GPVTRALSGTYRCKAANDQGE 478
L C + G P P+V AR G V G L G +G Y C A N G
Sbjct: 2685 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 2744
Query: 479 AVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSG-------E 531
A K V LTV+ +P + + P + + E L C A G+P P + + G
Sbjct: 2745 AHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2802
Query: 532 LGAVIEGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVE 588
+ G LR+A E AG Y C A N GSA + V+ P E + T E
Sbjct: 2803 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT--E 2860
Query: 589 GSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNAT 648
GS C+ G P+P++ G G + G Y C A
Sbjct: 2861 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE 2920
Query: 649 NRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGV------RC 702
N G + V ++ P +T P ++ L + L CAARG P+P + R
Sbjct: 2921 NAVGRARRRVHLTILVLPVF--TTLPGDRS-LRLGDRLWLRCAARGSPTPRIGWTVNDRP 2977
Query: 703 SREGIPWPE------QQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPP 756
EG+ + + VSRED+GTY C A N G V V+ PV+ A S
Sbjct: 2978 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 3037
Query: 757 GGVRP-GGNFTLTCRAEAWPPAQISW---RAPPGALNIGLSSNNSTLSVAGAMGSHGGEY 812
V P GG+ L C P I W P ++ N +L++ G Y
Sbjct: 3038 --VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRY 3095
Query: 813 ECAATNAHGRHARRITVRV 831
+C A N G A+++ + V
Sbjct: 3096 QCLAENEMG-VAKKVVILV 3113
Score = 106 bits (265), Expect = 9e-23
Identities = 145/572 (25%), Positives = 208/572 (36%), Gaps = 82/572 (14%)
Query: 321 SFPAPLLTLSEPSVSEG-------QMVTVTCAAGAQALVTLEGVPAAVP---GQPAQLQL 370
SFPA +P V G +V C+ G+ L G P +P P LQ+
Sbjct: 611 SFPAAC----DPPVHRGWGAHPKPPLVEGWCSPGS-----LWGEPTGIPVAYSLPPPLQI 661
Query: 371 NATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLR 430
+ D + C AT ++ GE+ R L+VL P ++ P + E TL
Sbjct: 662 EKVDLRDEGIYTCAAT-NLAGES---KREVALKVLVPPNIEPG--PVNKAVLENASVTLE 715
Query: 431 CEARGNPEPSVHCARSDGGAVLALGLL----GPVTR------ALSGTYRCKAANDQGEAV 480
C A G P P V + +G+ G V R + +G+YRC A+N G
Sbjct: 716 CLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 775
Query: 481 KDVTLTVEYAPALD-SVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGEL------- 532
L V P + P + L T L+C A G P P ++ ++ G
Sbjct: 776 LRYGLRVNVPPRITLPPSLPGPV--LVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP 833
Query: 533 ------GAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTW 586
G + L +G Y C A + G ++V + V P N +
Sbjct: 834 GLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEEL--NVSV 891
Query: 587 VEGSGRLFSCEVDGKPQPSVKCVGSGGATE---GVLLPLAPPDPSPRAPRIPRVLAPGIY 643
V C+ P P + G E GV L D + V G Y
Sbjct: 892 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA---DKALLQVDRADVWDAGHY 948
Query: 644 VCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCS 703
C A N+ G K ++ P SH + ++L+C RG P P +
Sbjct: 949 TCEALNQAGRSEKHYNLNVWVAPVFPLRE--SHTLTVREGHPTSLSCECRGVPFPKISWR 1006
Query: 704 REGIPWPEQ----QRVSR------------EDAGTYHCVATNAHGTDSRTVTVGVEYRPV 747
++G P P + Q VS GTY C +N G S+ + + V P
Sbjct: 1007 KDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ 1066
Query: 748 VAELAASPPG-GVRPGGNFTLTCRAEAWPPAQISWRA---PPGA-LNIGLSSNNSTLSVA 802
+A P V G TL C A PP ++W P GA L + L + +L V
Sbjct: 1067 IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVE 1126
Query: 803 GAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
A +H G Y C A N GR R+ + V P
Sbjct: 1127 RAQAAHTGRYSCVAENLAGRAERKFELSVLVP 1158
Score = 104 bits (260), Expect = 3e-22
Identities = 119/463 (25%), Positives = 173/463 (37%), Gaps = 56/463 (12%)
Query: 426 EQTLRCEARGNPEPSVHCARSDGGAVLALGL-----------LGPVTRALSGTYRCKAAN 474
E L CEA G P P++ + G +A G+ + + +G Y C A N
Sbjct: 2773 EVLLPCEASGIPRPTITWQKE--GLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 2830
Query: 475 DQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGA 534
G A+ L V+ P +++ G P+ T EG+ A L C A G P P++ + G+ +
Sbjct: 2831 SAGSAMGKTRLVVQVPPVIEN-GLPDLST-TEGSHAFLPCKARGSPEPNITWDKDGQPVS 2888
Query: 535 VIEGLLRVAR-----------EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSN 583
EG + + AGTY C A N G A + V +T+ P F + P +
Sbjct: 2889 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFT--TLPGD 2946
Query: 584 WTWVEGSGRLFSCEVDGKPQPSVK-CVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAP-G 641
+ G C G P P + V TEGV + D R G
Sbjct: 2947 RSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV----SEQDGGSTLQRAAVSREDSG 3002
Query: 642 IYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVR 701
YVC A NR G V + P + + S+ G L C RG P P +
Sbjct: 3003 TYVCWAENRVGRTQAVSFVHVKEAPVL-QGEAFSYLVEPVGGSIQ-LDCVVRGDPVPDIH 3060
Query: 702 CSREGIPWPEQQ-------------RVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVV 748
++G+P R R+DAG Y C+A N G + V + ++ PV
Sbjct: 3061 WIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3120
Query: 749 AELAASPPGGVRPGGNFTLTCRAEAWPPAQISW---RAPPGALNIGLSSNNSTLSVAGAM 805
VR G + L C+A P I W P A + + +L +
Sbjct: 3121 Q--VEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVE 3178
Query: 806 GSHGGEYECAATNAHGRHARR--ITVRVAGPWLWVAVGGAAGG 846
G Y+C A N G R + VR W ++ G G
Sbjct: 3179 TGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVING 3221
Score = 102 bits (255), Expect = 1e-21
Identities = 130/559 (23%), Positives = 192/559 (34%), Gaps = 90/559 (16%)
Query: 354 LEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDS 413
L G P + L L + D + C AT +V G T +R A+L V P + +
Sbjct: 45 LHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEV-GST---SRRAKLVVYVPPSIRED 100
Query: 414 DCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLG--------------- 458
+ + G TL C+A G P P + + + LG G
Sbjct: 101 GRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRL 160
Query: 459 -------PVTRALSGTYRCKAANDQGEAVKDVTLTVEYA----------------PALDS 495
R G + A G A A P++
Sbjct: 161 LDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLG 220
Query: 496 VGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEG-----------LLRVAR 544
G + + L G + L C GVP P V + + V+ G +LR+
Sbjct: 221 AGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQ--PVLPGGPHLQVQEDGQVLRITG 278
Query: 545 EHAGT---YRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGK 601
H G Y+C A +P G A++ + V P + +E CE G
Sbjct: 279 SHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGV 338
Query: 602 PQPSVKCVGSGGATEGVLLPLAPPDPSPRAPR---IPRVLAP--GIYVCNATNRHGSVAK 656
P P++ +G LLP + R R + R + G+Y C A+N G+ K
Sbjct: 339 PTPNITWF-----KDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEK 393
Query: 657 TVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVS 716
+ PP ++ + + AL C ARG PSP + EG+P E
Sbjct: 394 ATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESR 453
Query: 717 RE--------------DAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRP- 761
E +G Y CVA++ G +V V+ P + L A G V
Sbjct: 454 LETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQL--LVAEGLGQVTTI 511
Query: 762 -GGNFTLTCRAEAWPPAQISW----RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAA 816
G L C+A P I W R + ++S +TL + H G + C A
Sbjct: 512 VGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQA 571
Query: 817 TNAHGRHARRITVRVAGPW 835
TN G + V V G W
Sbjct: 572 TNEAGTAGAEVEVSVHGEW 590
Score = 100 bits (250), Expect = 5e-21
Identities = 142/610 (23%), Positives = 223/610 (36%), Gaps = 84/610 (13%)
Query: 290 ASAEQEGARQLVCNVTLGGENRETRENVTIY-SFPAPLLTLSEPSVSEGQMVTVTCAAGA 348
A QEG C+ +G +++ + V + P ++ SV + + T+ C A
Sbjct: 1034 AQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATG 1093
Query: 349 QALVTL----EGVPAA------VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNR 398
+ T+ +G P + Q L + + + C A ++ G R
Sbjct: 1094 KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRA---ER 1149
Query: 399 SAELRVLYAPRL-DDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGA------- 450
EL VL P L D D + T TL CEA G P P++ R +
Sbjct: 1150 KFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 1209
Query: 451 VLALGLLGPVTRAL---SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEG 507
+LA G + +T+ SG Y C A+N+ GEA ++ ++ V P++++ E I L+G
Sbjct: 1210 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG 1269
Query: 508 TEASLSCVAHGVPPPDVICVRSGELGA-----------VIEGLLRVAREHAGTYRCEATN 556
A L C G P P + + G A V+ +L+ AG Y C A N
Sbjct: 1270 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1329
Query: 557 PRGSAAKNVAVTVEYGPRF---EEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGG 613
G K+ ++V P E S T + CE P P++ + G
Sbjct: 1330 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1389
Query: 614 ATEGVL-LPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDEST 672
E + L P + + A G Y C TN G K V PP + +
Sbjct: 1390 PFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLIPPSISKDD 1448
Query: 673 CPSHQTWLEGAEAS-----ALACAARGRPSPGVRCSREGIPWPEQQRV------------ 715
P + ++ + L C + P P +R ++G P R+
Sbjct: 1449 -PLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ 1507
Query: 716 --SREDAGTYHCVATNAHGTDSRTVTVGVEYRPV---VAELAAS---------PPGGVRP 761
D+G Y CVATN G D + V ++ P+ V + +A+ GGV
Sbjct: 1508 PTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTE 1567
Query: 762 GGNFT------LTCRAEAWPPAQISWRAPPGALNIG----LSSNNSTLSVAGAMGSHGGE 811
L C A PP ++W L+ G + L + + G
Sbjct: 1568 YREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR 1627
Query: 812 YECAATNAHG 821
Y C A+N G
Sbjct: 1628 YSCKASNEVG 1637
Score = 93.2 bits (230), Expect = 1e-18
Identities = 128/544 (23%), Positives = 194/544 (35%), Gaps = 94/544 (17%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
LQ+ + +D + C T ++ GE +KN E VL P + D E +
Sbjct: 1406 LQILNAQKEDAGQYTCVVTNEL-GEA-VKNYHVE--VLIPPSISKDDPLGEVGVKEVKTK 1461
Query: 428 -----TLRCEARGNPEPSVHCARSDGGAVLA---LGLLG--------PVTRALSGTYRCK 471
TL CE+ P P++ + DG V L +LG P + SG Y C
Sbjct: 1462 VNSTLTLECESWAVPPPTIRWYK-DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1520
Query: 472 AANDQGEAVKDVTLTVEYAPALDSVG------------------CPERITWLEGTEASLS 513
A N GE +D + ++ P VG E +E A L
Sbjct: 1521 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1580
Query: 514 CVAHGVPPPDVICVR------SGELGAVIEG-----LLRVAREHAGTYRCEATNPRGSAA 562
C + +PPPD+ R +G+ +V++G + V E+AG Y C+A+N G
Sbjct: 1581 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDW 1640
Query: 563 KNVAVTVEYGPRF--EEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLL 620
+ + V P + T S C G P P++ + +G
Sbjct: 1641 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-------- 1692
Query: 621 PLAPPDPSPRAPRIP----------RVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDE 670
P PSPR + V Y+C A N+ GS K + + PP +
Sbjct: 1693 --LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG 1750
Query: 671 STCPSHQTWLEGAEASALACAARGRPSPGVRCSREG-----------IPWPEQQRVSR-- 717
L + + L C P+P V ++ +P ++ R
Sbjct: 1751 LDLEQVTAILNSSVS--LPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRAR 1808
Query: 718 -EDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGG--VRPGGNFTLTCRAEAW 774
D+G Y C A NA G D + V + V P + P VR G L+C +A
Sbjct: 1809 LSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 1868
Query: 775 PPAQISWRAPPGALNIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVR 830
P ++W L + + L + A S G Y C +N G R T+
Sbjct: 1869 PEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLT 1928
Query: 831 VAGP 834
V P
Sbjct: 1929 VQVP 1932
Score = 92.0 bits (227), Expect = 2e-18
Identities = 117/467 (25%), Positives = 160/467 (34%), Gaps = 60/467 (12%)
Query: 424 GPEQTLRCEARGNPEPSVHCARS-----DGGAVLALGLLGPVTRALS------GTYRCKA 472
G + L+C G P P V + GG L + G V R G Y+C A
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVA 291
Query: 473 ANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGEL 532
+ G+ +D L V P + + +E L C A GVP P++ + G L
Sbjct: 292 FSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGAL 351
Query: 533 -----------GAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFE-EPSC 580
G L R AG Y C+A+N G+A K + V P E
Sbjct: 352 LPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGR 411
Query: 581 PSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAP 640
P V G C G P P++ G D S P +
Sbjct: 412 PYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASS 471
Query: 641 GIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGV 700
G+Y C A++ G V + PP++ + T + G + L C A G P P +
Sbjct: 472 GLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVG-QPLELPCQASGSPVPTI 530
Query: 701 RCSREGIPWPEQ--------------QRVSREDAGTYHCVATNAHGTDSRTVTVGV--EY 744
+ + G P E V + +G + C ATN GT V V V E+
Sbjct: 531 QWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 590
Query: 745 RPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRA-PPGALNIGLSSNNS------ 797
P V E+ P G G + A PP W A P L G S S
Sbjct: 591 APGVLEV---PIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPT 647
Query: 798 ----------TLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
L + G Y CAATN G R + ++V P
Sbjct: 648 GIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP 694
Score = 82.4 bits (202), Expect = 2e-15
Identities = 119/490 (24%), Positives = 173/490 (35%), Gaps = 88/490 (17%)
Query: 431 CEARGNPEPSVHCARSD---------GGAVLALG--LLGPVTRALSGTYRCKAANDQGEA 479
C G P+P V + G AVL G L V+ A SG Y C+A N+ G
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 480 VKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGL 539
+ L V P++ G ++ + G +L C A+G P P+++ ++ +L V G
Sbjct: 84 SRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGW 143
Query: 540 L--------------RVARE----HAGTYRCEATNPRGSAAKNVAVT----------VEY 571
R+ E H + + RG+ A A T E
Sbjct: 144 AGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQ 203
Query: 572 GP---RFEEPSCPS--------NWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLL 620
P F P+ PS + G+ C G P P V+
Sbjct: 204 FPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKD-------RQ 256
Query: 621 PLAPPDPSPRAPRIPRVLA--------PGIYVCNATNRHGSVAKTVVVSAESPPEMDEST 672
P+ P P + +VL G Y C A + G A+ + +PP + S
Sbjct: 257 PVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSN 316
Query: 673 CPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRV--------------SRE 718
+E L C ARG P+P + ++G P +V
Sbjct: 317 ETGEVAVMED-HLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSS 375
Query: 719 DAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVR--PGGNFTLTCRAEAWPP 776
DAG Y C A+NA G + + V Y P E A P V+ G L C A P
Sbjct: 376 DAGVYTCKASNAVGAAEKATRLDV-YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPS 434
Query: 777 AQISWR---APPGALNIG-LSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRV- 831
+SW P N L ++ S L + + G Y C A++ G + +V V
Sbjct: 435 PTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ 494
Query: 832 AGPWLWVAVG 841
P L VA G
Sbjct: 495 VPPQLLVAEG 504
Score = 64.3 bits (155), Expect = 5e-10
Identities = 114/506 (22%), Positives = 168/506 (33%), Gaps = 93/506 (18%)
Query: 482 DVTLTVEYAPALDSVGC------PERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAV 535
DV LTV L++ GC ++TW +G + HG P V+ E G++
Sbjct: 12 DVALTV----GLEAGGCGTHGTPKPQVTWRKGPSSE---PLHGQPGVAVL-----EEGSL 59
Query: 536 IEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFS 595
L V+ +G Y C+ATN GS ++ + V P E +N + + G
Sbjct: 60 F--LASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLE 117
Query: 596 CEVDGKPQPSV------KCVG--SGGATEGVLL--------PLAPPDPSPRAPRIPRVLA 639
C+ +G P P + + VG G A G L L S PRI
Sbjct: 118 CDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRI----Q 173
Query: 640 PGIYVCNATNRHGSVAKTV----------------VVSAESPPEMDESTCPSHQTWLEGA 683
PG GS S +PP + + L GA
Sbjct: 174 PGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGA 233
Query: 684 EASALACAARGRPSPGVRCSREGIP---------WPEQQRVSR------EDAGTYHCVAT 728
+ L C G P+P V +++ P E +V R D G Y CVA
Sbjct: 234 DVE-LQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAF 292
Query: 729 NAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISW----RAP 784
+ G +R + V P + + V L C A P I+W
Sbjct: 293 SPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL 352
Query: 785 PGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAA 844
P + + + L + A S G Y C A+NA G + + V P + GA
Sbjct: 353 PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP---PTIEGAG 409
Query: 845 GGAALLAAGAGLAFYVQSTA--------------CKKGEYNVQEAESSGEAVCLNGAGGG 890
G ++ A AG ++ A E N E+ G + L G
Sbjct: 410 GRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEA 469
Query: 891 AGGAAGAEGGPEAAGGAAESPAEGEV 916
+ G A + E +V
Sbjct: 470 SSGLYSCVASSPAGEAVLQYSVEVQV 495
Score = 35.8 bits (81), Expect = 0.19
Identities = 68/295 (23%), Positives = 103/295 (34%), Gaps = 45/295 (15%)
Query: 223 TFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAF 282
T + P L R L +G + C G + R+ + D+ ++ V+ E D
Sbjct: 2933 TILVLPVFTTLPGDRSLRLGDRLWLRCAARG---SPTPRIGWTVNDRPVTEGVS-EQDGG 2988
Query: 283 VATATATASAEQEGARQLVCNVTLGGENRETRENVT--IYSFPAPLLT------LSEPSV 334
A S E G VC ENR R ++ AP+L L EP
Sbjct: 2989 STLQRAAVSREDSGT--YVC----WAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV- 3041
Query: 335 SEGQMVTVTCAAGAQALVTLEGVPAAVPG---------QPAQLQLNATENDDRRSFFCDA 385
G + + C + + + +P Q L ++ TE DD + C A
Sbjct: 3042 --GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLA 3099
Query: 386 TLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCAR 445
+ E + + L + AP P+ T G + LRC+A G P P++ +
Sbjct: 3100 ----ENEMGVAKKVVILVLQSAPVFQVE--PQDMTVRSGDDVALRCQATGEPTPTIEWLQ 3153
Query: 446 SDGGAVLALGL---------LGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAP 491
+ + L L V +GTY C A N G A L V P
Sbjct: 3154 AGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 134 bits (337), Expect = 4e-31
Identities = 152/540 (28%), Positives = 214/540 (39%), Gaps = 69/540 (12%)
Query: 341 TVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSA 400
TVT Q LV + A GQ +L++ + D+ + C + +V GE + R+
Sbjct: 1781 TVTWYKDGQPLVLAQRTQALRGGQ--RLEIQEAQVSDKGLYSCKVS-NVAGEAV---RTF 1834
Query: 401 ELRVLYAPRLDDSDCPRSWTWPE--GPEQTLRCEARGNPEPSV--------------HCA 444
L V P ++ P++ T + G L C+ G P P+V H
Sbjct: 1835 TLTVQVPPTFEN---PKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGV 1891
Query: 445 RSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITW 504
S GG L L L P A +GTY C A N Q EA KD + V AP + S G
Sbjct: 1892 VSRGGR-LQLSRLQP---AQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHV 1947
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG---------ELGAVIEG----LLRVAREHAGTYR 551
LEG E L C A G PPPDV ++ G L ++G L + AG Y
Sbjct: 1948 LEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYT 2007
Query: 552 CEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFS--CEVDGKPQPSVKCV 609
C A NP G A+ V V P ++ + T V G L + C V G P V +
Sbjct: 2008 CVAHNPAGEDARLHTVNVLVPPTIKQ-GADGSGTLVSRPGELVTMVCPVRGSPPIHVSWL 2066
Query: 610 GSGGATEGVLLPLAPP---DPSPRAPRIPRV--LAPGIYVCNATNRHGSVAKTVVVSAES 664
+G+ LPL+ S RI +V GI+ C A + G + + +
Sbjct: 2067 -----KDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV 2121
Query: 665 PPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQ----------QR 714
PP ++ + + G+ L C ARG P P V ++G P Q +
Sbjct: 2122 PPVLEPVEFQNDVVVVRGSLVE-LPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEA 2180
Query: 715 VSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAW 774
V D+GTY CVA + G R + V P + + + PG L C A+
Sbjct: 2181 VGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGT 2240
Query: 775 PPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
P I+W AL L +N+ V + G Y C A + G + VRV P
Sbjct: 2241 PQPNITWHKDGQALT-RLENNSRATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAP 2297
Score = 123 bits (308), Expect = 9e-28
Identities = 165/656 (25%), Positives = 248/656 (37%), Gaps = 94/656 (14%)
Query: 242 GSERPVSCTLDGLFPASEARVYLALGD---QNLSPDVT--LEGDAFVATATATASAEQEG 296
G E + C DG P A +L G Q++ P + L+G + V + A G
Sbjct: 1950 GQEVRLDCEADGQPPPDVA--WLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDA---G 2004
Query: 297 ARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSE-GQMVTVTCAAGAQALVTLE 355
A V + G + R NV + S VS G++VT+ C + +
Sbjct: 2005 AYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVS 2064
Query: 356 GVPAAVP----------GQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVL 405
+ +P G L+++ + D F C A + +R+ L+V
Sbjct: 2065 WLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAG----VADRNFTLQVQ 2120
Query: 406 YAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGL-------LG 458
P L+ + G L CEARG P P V + DG +L+ L L
Sbjct: 2121 VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMK-DGEPLLSQSLEQGPSLQLE 2179
Query: 459 PVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHG 518
V SGTY C A ++ GEA + LTV P ++ G P ++ G L C A G
Sbjct: 2180 AVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQG 2239
Query: 519 VPPPDVICVRSGELGAVIEGLLRVAR----EHAGTYRCEATNPRGSAAKNVAVTVEYGPR 574
P P++ + G+ +E R R AG Y C A +P G+ K+ V V+ P
Sbjct: 2240 TPQPNITWHKDGQALTRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFRVRVQAPPN 2299
Query: 575 FEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRI 634
P P + + C V+ +P P + +G++L P R
Sbjct: 2300 IVGPRGPRFVVGLAPGQLVLECSVEAEPAPKIT-----WHRDGIVLQEDAHTQFPERGRF 2354
Query: 635 PRVLA-----PGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALA 689
++ A G Y C A N GS + V + P + S P+ + + + L
Sbjct: 2355 LQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTI-RSGPPAVNVSVN--QTALLP 2411
Query: 690 CAARGRPSPGVRCSREGIPWPEQ--------------QRVSREDAGTYHCVATNAHGTDS 735
C A G P+P V ++ +P + Q V +DAG Y C+A+N+ G+D
Sbjct: 2412 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 2471
Query: 736 RTVTVGVEYRPVVAELAASPPGGVRPGGNFTLT--------CRAEAWPPAQISW------ 781
+ + V P + A SP N TLT C A P + W
Sbjct: 2472 QGRDLRVLEPPAI---APSP-------SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQK 2521
Query: 782 ---RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
R GA + L SN L+ G S ++EC +N G R V V P
Sbjct: 2522 LDFRLQQGAYRL-LPSNALLLTAPGPQDS--AQFECVVSNEVGEAHRLYQVTVHVP 2574
Score = 118 bits (296), Expect = 2e-26
Identities = 136/467 (29%), Positives = 184/467 (39%), Gaps = 63/467 (13%)
Query: 401 ELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHC--------ARSDGGA-- 450
+LRVL P + S P + T L CEA G+P+P V R GA
Sbjct: 2475 DLRVLEPPAIAPS--PSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYR 2532
Query: 451 -----VLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWL 505
L L GP S + C +N+ GEA + +TV P + +T +
Sbjct: 2533 LLPSNALLLTAPGPQD---SAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMM 2589
Query: 506 EGTEASLSCVAHGVPPPDVICVRSG-ELGA-------VIEGLLRVARE---HAGTYRCEA 554
L+C + G+P P V ++G +LGA G L + + HAG Y C A
Sbjct: 2590 --APVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSA 2647
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSG-G 613
N G A K+V +TV+ P + PS V L CE G P+P++ G
Sbjct: 2648 RNSAGVAHKHVFLTVQASPVVK--PLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLN 2705
Query: 614 ATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTC 673
GV + P A P G Y+C A N GS + + PP + E+
Sbjct: 2706 VATGVSTQVLPGGQLRIAHASPE--DAGNYLCIAKNSAGSAMGKTRLVVQVPPVI-ENGL 2762
Query: 674 PSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQ--------------RVSRED 719
P T EG+ A L C ARG P P + ++G P + + +D
Sbjct: 2763 PDLST-TEGSHA-FLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQD 2820
Query: 720 AGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPG--GVRPGGNFTLTCRAEAWPPA 777
AGTY C A NA G R V + + PV L PG +R G L C A P
Sbjct: 2821 AGTYTCTAENAVGRARRRVHLTILVLPVFTTL----PGDRSLRLGDRLWLRCAARGSPTP 2876
Query: 778 QISWRAPPGALNIGLSSNN--STLSVAGAMGSHGGEYECAATNAHGR 822
+I W + G+S + STL A G Y C A N GR
Sbjct: 2877 RIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGR 2923
Score = 118 bits (295), Expect = 3e-26
Identities = 118/476 (24%), Positives = 172/476 (36%), Gaps = 73/476 (15%)
Query: 424 GPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLG------------------------- 458
G TL C+A G P P + + + LG G
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92
Query: 459 PVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHG 518
+ SG Y C+A N G A +D L V P++ G + + L G + L C G
Sbjct: 93 RIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSG 152
Query: 519 VPPPDVICVRSGELGAVIEG-----------LLRVAREHA---GTYRCEATNPRGSAAKN 564
VP P V + + V+ G +LR+ H G Y+C A +P G A++
Sbjct: 153 VPTPQVEWTKDRQ--PVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARD 210
Query: 565 VAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAP 624
+ V P + +E CE G P P++ +G LLP +
Sbjct: 211 FQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWF-----KDGALLPTST 265
Query: 625 PDPSPRAPR---IPRVLA--PGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTW 679
R R + R + G+Y C A+N G+ K + PP ++ + +
Sbjct: 266 KVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVK 325
Query: 680 LEGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSRE--------------DAGTYHC 725
AL C ARG PSP + EG+P E E +G Y C
Sbjct: 326 AVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSC 385
Query: 726 VATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRP--GGNFTLTCRAEAWPPAQISW-- 781
VA++ G +V V+ P + L A G V G L C+A P I W
Sbjct: 386 VASSPAGEAVLQYSVEVQVPPQL--LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQ 443
Query: 782 --RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPW 835
R + ++S +TL + H G + C ATN G + V V G W
Sbjct: 444 NGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEW 499
Score = 112 bits (280), Expect = 2e-24
Identities = 160/639 (25%), Positives = 232/639 (36%), Gaps = 111/639 (17%)
Query: 297 ARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEPSVSEGQMVTVTCAAGAQALVTL- 354
A C + E N+ ++ P PL +V EG ++C +
Sbjct: 854 AGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKIS 913
Query: 355 ---EGVPAAVPGQPAQLQ----------LNATENDDRRSFFCDATLDVDGETLIKNRSAE 401
+G P +PG+ A LQ L + ++ C+ + +V G + ++ +
Sbjct: 914 WRKDGQP--LPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECS-NVVGNS---SQDLQ 967
Query: 402 LRVLYAPRL-DDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDG---GAVLALGLL 457
L V P++ + P + + TL C A G P P+V R DG GA L L L
Sbjct: 968 LEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAELGLQLQ 1026
Query: 458 GP--------VTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCP-ERITWLEGT 508
A +G Y C A N G A + L+V P L P IT +
Sbjct: 1027 NQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHS 1086
Query: 509 EASLSCVAHGVPPPDVICVRSGE-----------LGAVIEGLLRVAREHAGTYRCEATNP 557
+L C A G+PPP + R E G + + + + +G Y C A+N
Sbjct: 1087 PLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNE 1146
Query: 558 RGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEG 617
G A +N +V V P E ++G C V G PQP + G
Sbjct: 1147 AGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGR---- 1202
Query: 618 VLLPLAPPDPSPRAPR--IPRVL-----APGIYVCNATNRHGSVAKTVVVSAESPPEMDE 670
PLA D +P + +VL + G Y C A N G K +S P
Sbjct: 1203 ---PLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAP---- 1255
Query: 671 STCPSHQTWLEGAEASA-------------LACAARGRPSPGVRCSREGIPWPEQQRVS- 716
T L GAE SA L C A PSP + ++G P+ + +
Sbjct: 1256 -------TILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 1308
Query: 717 -------------REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAE---LAASPPGGVR 760
+EDAG Y CV TN G + V V P +++ LA V+
Sbjct: 1309 LPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVK 1368
Query: 761 PGGNFTLTCRAEAW--PPAQISWR------APPGALNIGLSSNNSTLSVAGAMGSHGGEY 812
N TLT E+W PP I W P L + L + S G Y
Sbjct: 1369 TKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV--LGEGRLLQIQPTQVSDSGRY 1426
Query: 813 ECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLA 851
C ATN G + V + P ++ VG + +L+
Sbjct: 1427 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILS 1465
Score = 110 bits (276), Expect = 5e-24
Identities = 156/619 (25%), Positives = 228/619 (36%), Gaps = 68/619 (10%)
Query: 254 LFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGA--RQLVCNVTLGGENR 311
L P S L G + P + + ++ A+ +A ++++G R L +
Sbjct: 2431 LDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSN 2490
Query: 312 ETRENVTIYSFPAPLLTLSEPSV---SEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQL 368
T T P +P V +GQ + GA L+ + PG
Sbjct: 2491 LTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGP---- 2546
Query: 369 QLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQT 428
D F C + +V GE +R ++ V P + D +T
Sbjct: 2547 -------QDSAQFECVVSNEV-GEA---HRLYQVTVHVPPTIADDQT--DFTVTMMAPVV 2593
Query: 429 LRCEARGNPEPSVHC--------ARSDGGAVLALGLL--GPVTRALSGTYRCKAANDQGE 478
L C + G P P+V AR G V G L G +G Y C A N G
Sbjct: 2594 LTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGV 2653
Query: 479 AVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSG-------E 531
A K V LTV+ +P + + P + + E L C A G+P P + + G
Sbjct: 2654 AHKHVFLTVQASPVVKPL--PSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVS 2711
Query: 532 LGAVIEGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVE 588
+ G LR+A E AG Y C A N GSA + V+ P E + T E
Sbjct: 2712 TQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTT--E 2769
Query: 589 GSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNAT 648
GS C+ G P+P++ G G + G Y C A
Sbjct: 2770 GSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE 2829
Query: 649 NRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGV------RC 702
N G + V ++ P +T P ++ L + L CAARG P+P + R
Sbjct: 2830 NAVGRARRRVHLTILVLPVF--TTLPGDRS-LRLGDRLWLRCAARGSPTPRIGWTVNDRP 2886
Query: 703 SREGIPWPE------QQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPP 756
EG+ + + VSRED+GTY C A N G V V+ PV+ A S
Sbjct: 2887 VTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYL 2946
Query: 757 GGVRP-GGNFTLTCRAEAWPPAQISW---RAPPGALNIGLSSNNSTLSVAGAMGSHGGEY 812
V P GG+ L C P I W P ++ N +L++ G Y
Sbjct: 2947 --VEPVGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRY 3004
Query: 813 ECAATNAHGRHARRITVRV 831
+C A N G A+++ + V
Sbjct: 3005 QCLAENEMG-VAKKVVILV 3022
Score = 107 bits (268), Expect = 4e-23
Identities = 123/491 (25%), Positives = 182/491 (37%), Gaps = 59/491 (12%)
Query: 398 RSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGL- 456
R +LRV P + S+ E L CEARG P P++ + GA+L
Sbjct: 209 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKD--GALLPTSTK 266
Query: 457 -----------LGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSV-GCPERITW 504
LG + +G Y CKA+N G A K L V P ++ G P +
Sbjct: 267 VVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKA 326
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG-----------ELGAVIEGLLRVAREHAGTYRCE 553
+ G +L CVA G P P + G E + L +G Y C
Sbjct: 327 VAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCV 386
Query: 554 ATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGG 613
A++P G A +V V+ P+ T + G C+ G P P+++ + +G
Sbjct: 387 ASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGR 446
Query: 614 ATEGVL-LPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVS--AESPPEMDE 670
E + + +A + + + G++ C ATN G+ V VS E P + E
Sbjct: 447 PAEELAGVQVASQGTTLHIDHV-ELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLE 505
Query: 671 STCPSHQTWLEGAEASALAC--------AARGRP-------SPGVRCSRE-------GIP 708
+ E + AC A +P SPG +P
Sbjct: 506 VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 565
Query: 709 WPEQ-QRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTL 767
P Q ++V D G Y C ATN G R V + V P + + V + TL
Sbjct: 566 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNK--AVLENASVTL 623
Query: 768 TCRAEAWPPAQISW----RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRH 823
C A PP +SW + + + +S + L + A S G Y C A+N G
Sbjct: 624 ECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 683
Query: 824 ARRITVRVAGP 834
R +RV P
Sbjct: 684 ELRYGLRVNVP 694
Score = 105 bits (263), Expect = 1e-22
Identities = 145/572 (25%), Positives = 207/572 (36%), Gaps = 82/572 (14%)
Query: 321 SFPAPLLTLSEPSVSEG-------QMVTVTCAAGAQALVTLEGVPAAVP---GQPAQLQL 370
SFPA +P V G +V C+ G+ L G P +P P LQ+
Sbjct: 520 SFPAAC----DPPVHRGWGAHPKPPLVEGWCSPGS-----LWGEPTGIPVAYSLPPPLQI 570
Query: 371 NATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLR 430
+ D + C AT ++ GE+ R L+VL P ++ P + E TL
Sbjct: 571 EKVDLRDEGIYTCAAT-NLAGES---KREVALKVLVPPNIEPG--PVNKAVLENASVTLE 624
Query: 431 CEARGNPEPSVHCARSDGGAVLALGLL----GPVTR------ALSGTYRCKAANDQGEAV 480
C A G P P V + +G+ G V R + +G+YRC A+N G
Sbjct: 625 CLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 684
Query: 481 KDVTLTVEYAPALD-SVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGEL------- 532
L V P + P + L T L+C A G P P ++ ++ G
Sbjct: 685 LRYGLRVNVPPRITLPPSLPGPV--LVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTP 742
Query: 533 ------GAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTW 586
G + L +G Y C A + G ++V + V P N +
Sbjct: 743 GLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEEL--NVSV 800
Query: 587 VEGSGRLFSCEVDGKPQPSVKCVGSGGATE---GVLLPLAPPDPSPRAPRIPRVLAPGIY 643
V C+ P P + G E GV L D + V G Y
Sbjct: 801 VANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSA---DKALLQVDRADVWDAGHY 857
Query: 644 VCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCS 703
C A N+ G K ++ P SH + + L+C RG P P +
Sbjct: 858 TCEALNQAGHSEKHYNLNVWVAPVFPLRE--SHTLTVREGHPTRLSCECRGVPFPKISWR 915
Query: 704 REGIPWPEQ----QRVSR------------EDAGTYHCVATNAHGTDSRTVTVGVEYRPV 747
++G P P + Q VS GTY C +N G S+ + + V P
Sbjct: 916 KDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ 975
Query: 748 VAELAASPPG-GVRPGGNFTLTCRAEAWPPAQISWRA---PPGA-LNIGLSSNNSTLSVA 802
+A P V G TL C A PP ++W P GA L + L + +L V
Sbjct: 976 IAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVE 1035
Query: 803 GAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
A +H G Y C A N GR R+ + V P
Sbjct: 1036 RAQAAHTGRYSCVAENLAGRAERKFELSVLVP 1067
Score = 105 bits (261), Expect = 3e-22
Identities = 119/463 (25%), Positives = 174/463 (37%), Gaps = 56/463 (12%)
Query: 426 EQTLRCEARGNPEPSVHCARSDGGAVLALGL-----------LGPVTRALSGTYRCKAAN 474
E L CEA G P P++ + G +A G+ + + +G Y C A N
Sbjct: 2682 EVLLPCEASGIPRPTITWQKE--GLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKN 2739
Query: 475 DQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGA 534
G A+ L V+ P +++ G P+ T EG+ A L C A G P P++ + G+ +
Sbjct: 2740 SAGSAMGKTRLVVQVPPVIEN-GLPDLST-TEGSHAFLPCKARGSPEPNITWDKDGQPVS 2797
Query: 535 VIEGLLRVAR-----------EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSN 583
EG + + AGTY C A N G A + V +T+ P F + P +
Sbjct: 2798 GAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFT--TLPGD 2855
Query: 584 WTWVEGSGRLFSCEVDGKPQPSVK-CVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAP-G 641
+ G C G P P + V TEGV + D R G
Sbjct: 2856 RSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV----SEQDGGSTLQRAAVSREDSG 2911
Query: 642 IYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVR 701
YVC A NR G V + P + + S+ G L C RG P P +
Sbjct: 2912 TYVCWAENRVGRTQAVSFVHVKEAPVL-QGEAFSYLVEPVGGSIQ-LDCVVRGDPVPDIH 2969
Query: 702 CSREGIPWPEQ-------------QRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVV 748
++G+P +R R+DAG Y C+A N G + V + ++ PV
Sbjct: 2970 WIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVF 3029
Query: 749 AELAASPPGGVRPGGNFTLTCRAEAWPPAQISW---RAPPGALNIGLSSNNSTLSVAGAM 805
VR G + L C+A P I W P A + + +L +
Sbjct: 3030 Q--VEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVE 3087
Query: 806 GSHGGEYECAATNAHGRHARR--ITVRVAGPWLWVAVGGAAGG 846
G Y+C A N G R + VR W ++ G G
Sbjct: 3088 TGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSMTGVING 3130
Score = 100 bits (250), Expect = 5e-21
Identities = 142/610 (23%), Positives = 223/610 (36%), Gaps = 84/610 (13%)
Query: 290 ASAEQEGARQLVCNVTLGGENRETRENVTIY-SFPAPLLTLSEPSVSEGQMVTVTCAAGA 348
A QEG C+ +G +++ + V + P ++ SV + + T+ C A
Sbjct: 943 AQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATG 1002
Query: 349 QALVTL----EGVPAA------VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNR 398
+ T+ +G P + Q L + + + C A ++ G R
Sbjct: 1003 KPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAE-NLAGRA---ER 1058
Query: 399 SAELRVLYAPRL-DDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGA------- 450
EL VL P L D D + T TL CEA G P P++ R +
Sbjct: 1059 KFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTY 1118
Query: 451 VLALGLLGPVTRAL---SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEG 507
+LA G + +T+ SG Y C A+N+ GEA ++ ++ V P++++ E I L+G
Sbjct: 1119 LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDG 1178
Query: 508 TEASLSCVAHGVPPPDVICVRSGELGA-----------VIEGLLRVAREHAGTYRCEATN 556
A L C G P P + + G A V+ +L+ AG Y C A N
Sbjct: 1179 QTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAAN 1238
Query: 557 PRGSAAKNVAVTVEYGPRF---EEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGG 613
G K+ ++V P E S T + CE P P++ + G
Sbjct: 1239 AVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA 1298
Query: 614 ATEGVL-LPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDEST 672
E + L P + + A G Y C TN G K V PP + +
Sbjct: 1299 PFEASRNIQLLPGTHGLQILNAQKEDA-GQYTCVVTNELGEAVKNYHVEVLIPPSISKDD 1357
Query: 673 CPSHQTWLEGAEAS-----ALACAARGRPSPGVRCSREGIPWPEQQRV------------ 715
P + ++ + L C + P P +R ++G P R+
Sbjct: 1358 -PLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQ 1416
Query: 716 --SREDAGTYHCVATNAHGTDSRTVTVGVEYRPV---VAELAAS---------PPGGVRP 761
D+G Y CVATN G D + V ++ P+ V + +A+ GGV
Sbjct: 1417 PTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTE 1476
Query: 762 GGNFT------LTCRAEAWPPAQISWRAPPGALNIG----LSSNNSTLSVAGAMGSHGGE 811
L C A PP ++W L+ G + L + + G
Sbjct: 1477 YREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGR 1536
Query: 812 YECAATNAHG 821
Y C A+N G
Sbjct: 1537 YSCKASNEVG 1546
Score = 93.6 bits (231), Expect = 8e-19
Identities = 128/544 (23%), Positives = 194/544 (35%), Gaps = 94/544 (17%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
LQ+ + +D + C T ++ GE +KN E VL P + D E +
Sbjct: 1315 LQILNAQKEDAGQYTCVVTNEL-GEA-VKNYHVE--VLIPPSISKDDPLAEVGVKEVKTK 1370
Query: 428 -----TLRCEARGNPEPSVHCARSDGGAVLA---LGLLG--------PVTRALSGTYRCK 471
TL CE+ P P++ + DG V L +LG P + SG Y C
Sbjct: 1371 VNSTLTLECESWAVPPPTIRWYK-DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCV 1429
Query: 472 AANDQGEAVKDVTLTVEYAPALDSVG------------------CPERITWLEGTEASLS 513
A N GE +D + ++ P VG E +E A L
Sbjct: 1430 ATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLY 1489
Query: 514 CVAHGVPPPDVICVR------SGELGAVIEG-----LLRVAREHAGTYRCEATNPRGSAA 562
C + +PPPD+ R +G+ +V++G + V E+AG Y C+A+N G
Sbjct: 1490 CDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDW 1549
Query: 563 KNVAVTVEYGPRF--EEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLL 620
+ + V P + T S C G P P++ + +G
Sbjct: 1550 LHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-------- 1601
Query: 621 PLAPPDPSPRAPRIP----------RVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDE 670
P PSPR + V Y+C A N+ GS K + + PP +
Sbjct: 1602 --LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAG 1659
Query: 671 STCPSHQTWLEGAEASALACAARGRPSPGVRCSREG-----------IPWPEQQRVSR-- 717
L + + L C P+P V ++ +P ++ R
Sbjct: 1660 LDLEQVTAILNSSVS--LPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRAR 1717
Query: 718 -EDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGG--VRPGGNFTLTCRAEAW 774
D+G Y C A NA G D + V + V P + P VR G L+C +A
Sbjct: 1718 LSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDAL 1777
Query: 775 PPAQISWRAPPGALNIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVR 830
P ++W L + + L + A S G Y C +N G R T+
Sbjct: 1778 PEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLT 1837
Query: 831 VAGP 834
V P
Sbjct: 1838 VQVP 1841
Score = 76.3 bits (186), Expect = 1e-13
Identities = 93/406 (22%), Positives = 142/406 (34%), Gaps = 64/406 (15%)
Query: 491 PALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIEGLL---------- 540
P++ G ++ + G +L C A+G P P+++ ++ +L V G
Sbjct: 17 PSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ 76
Query: 541 ----------------RVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNW 584
R+ +G Y C A N G+A ++ + V P
Sbjct: 77 VGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEV 136
Query: 585 TWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLA----- 639
+ G+ C G P P V+ P+ P P + +VL
Sbjct: 137 LGLAGADVELQCWTSGVPTPQVEWTKD-------RQPVLPGGPHLQVQEDGQVLRITGSH 189
Query: 640 ---PGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRP 696
G Y C A + G A+ + +PP + S +E L C ARG P
Sbjct: 190 VGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMED-HLVQLLCEARGVP 248
Query: 697 SPGVRCSREGIPWPEQQRV--------------SREDAGTYHCVATNAHGTDSRTVTVGV 742
+P + ++G P +V DAG Y C A+NA G + + V
Sbjct: 249 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 308
Query: 743 EYRPVVAELAASPPGGVR--PGGNFTLTCRAEAWPPAQISWR---APPGALNIG-LSSNN 796
Y P E A P V+ G L C A P +SW P N L ++
Sbjct: 309 -YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG 367
Query: 797 STLSVAGAMGSHGGEYECAATNAHGRHARRITVRV-AGPWLWVAVG 841
S L + + G Y C A++ G + +V V P L VA G
Sbjct: 368 SVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEG 413
Score = 56.6 bits (135), Expect = 1e-07
Identities = 87/393 (22%), Positives = 132/393 (33%), Gaps = 54/393 (13%)
Query: 573 PRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSV------KCVGS--GGATEGVLLP--- 621
P E +N + + G C+ +G P P + + VG G A G L
Sbjct: 17 PSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQ 76
Query: 622 -----LAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSH 676
L S PRI + G+Y C A N+ G+ + + +PP + +
Sbjct: 77 VGGHRLLDEGQSLHFPRIQEGDS-GLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQE 135
Query: 677 QTWLEGAEASALACAARGRPSPGVRCSREGIPW---------PEQQRVSR------EDAG 721
L GA+ L C G P+P V +++ P E +V R D G
Sbjct: 136 VLGLAGADVE-LQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 194
Query: 722 TYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISW 781
Y CVA + G +R + V P + + V L C A P I+W
Sbjct: 195 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 254
Query: 782 RAP----PGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLW 837
P + + + L + A S G Y C A+NA G + + V P
Sbjct: 255 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVP--- 311
Query: 838 VAVGGAAGGAALLAAGAGLAFYVQSTA--------------CKKGEYNVQEAESSGEAVC 883
+ GA G ++ A AG ++ A E N E+ G +
Sbjct: 312 PTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLR 371
Query: 884 LNGAGGGAGGAAGAEGGPEAAGGAAESPAEGEV 916
L G + G A + E +V
Sbjct: 372 LESPGEASSGLYSCVASSPAGEAVLQYSVEVQV 404
Score = 35.4 bits (80), Expect = 0.25
Identities = 68/295 (23%), Positives = 102/295 (34%), Gaps = 45/295 (15%)
Query: 223 TFSLSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAF 282
T + P L R L +G + C G + R+ + D+ ++ V+ E D
Sbjct: 2842 TILVLPVFTTLPGDRSLRLGDRLWLRCAARG---SPTPRIGWTVNDRPVTEGVS-EQDGG 2897
Query: 283 VATATATASAEQEGARQLVCNVTLGGENRETRENVT--IYSFPAPLLT------LSEPSV 334
A S E G VC ENR R ++ AP+L L EP
Sbjct: 2898 STLQRAAVSREDSGT--YVC----WAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPV- 2950
Query: 335 SEGQMVTVTCAAGAQALVTLEGVPAAVPG---------QPAQLQLNATENDDRRSFFCDA 385
G + + C + + + +P Q L + TE DD + C A
Sbjct: 2951 --GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLA 3008
Query: 386 TLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCAR 445
+ E + + L + AP P+ T G + LRC+A G P P++ +
Sbjct: 3009 ----ENEMGVAKKVVILVLQSAPVFQVE--PQDMTVRSGDDVALRCQATGEPTPTIEWLQ 3062
Query: 446 SDGGAVLALGL---------LGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAP 491
+ + L L V +GTY C A N G A L V P
Sbjct: 3063 AGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 130 bits (326), Expect = 7e-30
Identities = 143/610 (23%), Positives = 229/610 (37%), Gaps = 75/610 (12%)
Query: 292 AEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEP---SVSEGQMVTVTCAAGA 348
A+ + C+V E +V +Y P L+ P V +T+ C A
Sbjct: 1608 AQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAG 1667
Query: 349 QALVTL----EGVPAA------VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNR 398
L +GVP + +L++ + + DR + C AT V GE IK
Sbjct: 1668 NPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVAT-SVAGEKEIKY- 1725
Query: 399 SAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARS-------DGGAV 451
E+ VL P ++ D + L C G+P P++ + DG +
Sbjct: 1726 --EVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKI 1783
Query: 452 LALGLLGPVTRAL---SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGT 508
L G + +A +G YRC AAN G+ K+ +TV P + S G ER+ ++
Sbjct: 1784 LLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVV-VKYK 1842
Query: 509 EASLSCVAHGVPPPDVICVRSGELGAVIEGLLRVAR------------EHAGTYRCEATN 556
+L C+A+G+P P + ++ + +G L++ E AG Y C ATN
Sbjct: 1843 PVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATN 1902
Query: 557 PRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSG---- 612
G +++ + V P E+ N T + + C+ G P P +
Sbjct: 1903 AAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS 1962
Query: 613 GATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDEST 672
G+T L A ++ GIY C A N G+ + P + S
Sbjct: 1963 GSTSMTFLNRGQIIDIESA----QISDAGIYKCVAINSAGATELFYSLQVHVAPSISGS- 2017
Query: 673 CPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQR---------------VSR 717
++ + L C ARG P+P + ++G P
Sbjct: 2018 --NNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQI 2075
Query: 718 EDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPA 777
D G Y CVA NA G R + + V P + + V L C+++A PP
Sbjct: 2076 SDTGRYTCVAVNAAGEKQRDIDLRVYVPPNI--MGEEQNVSVLISQAVELLCQSDAIPPP 2133
Query: 778 QISWRAPPGAL----NIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAG 833
++W L + +S N S L + A G Y C ATN G+ + V +
Sbjct: 2134 TLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNI-- 2191
Query: 834 PWLWVAVGGA 843
W+ +GG+
Sbjct: 2192 -WVPPNIGGS 2200
Score = 128 bits (321), Expect = 3e-29
Identities = 133/485 (27%), Positives = 192/485 (39%), Gaps = 57/485 (11%)
Query: 376 DDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARG 435
DD ++ C T + R+ +L V P + D P + + + C A G
Sbjct: 3869 DDTATYECTVTNGAGDD----KRTVDLTVQVPPSIADE--PTDFLVTKHAPAVITCTASG 3922
Query: 436 NPEPSVHCA--------RSDGGAVLALGLLGPVTRALS--GTYRCKAANDQGEAVKDVTL 485
P PS+H R DG +L+ G + + L+ G Y C A N G A + VTL
Sbjct: 3923 VPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTL 3982
Query: 486 TVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVR-------SGELGAVIEG 538
V P + P + + L C A G P P + + SG AV+
Sbjct: 3983 HVHEPPVIQPQ--PSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPS 4040
Query: 539 ----LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLF 594
+ R RE AGTY C A NP G+A + + V+ P P V+ L
Sbjct: 4041 GGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVIS-PHLKEYVIAVDKPITL- 4098
Query: 595 SCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSV 654
SCE DG P P + G A + S + + A G Y C A N GS
Sbjct: 4099 SCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDA-GHYTCMAANVAGSS 4157
Query: 655 AKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGI------- 707
+ + ++ PP + + H T E ++A L C A G P+P + ++ +
Sbjct: 4158 STSTKLTVHVPPRIRSTE--GHYTVNENSQA-ILPCVADGIPTPAINWKKDNVLLANLLG 4214
Query: 708 -----PWPEQ--QRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGV- 759
P+ E + V ED+G Y CVA NA G D+ TV++ V P EL PG V
Sbjct: 4215 KYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTEL----PGDVS 4270
Query: 760 -RPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNN--STLSVAGAMGSHGGEYECAA 816
G L+C+A P +++W + S N S L + G Y C A
Sbjct: 4271 LNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTA 4330
Query: 817 TNAHG 821
N+ G
Sbjct: 4331 ENSVG 4335
Score = 125 bits (314), Expect = 2e-28
Identities = 125/446 (28%), Positives = 186/446 (41%), Gaps = 58/446 (13%)
Query: 428 TLRCEARGNPEPSVHCARSDGGA--------VLALGLL--GPVTRALSGTYRCKAANDQG 477
TL CEA G P P + + DG A VL+ G L V +G Y C AAN G
Sbjct: 4097 TLSCEADGLPPPDITWHK-DGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAG 4155
Query: 478 EAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIE 537
+ LTV P + S T E ++A L CVA G+P P + + L A +
Sbjct: 4156 SSSTSTKLTVHVPPRIRST--EGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLL 4213
Query: 538 G-----------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTW 586
G L V E +G Y C A N G V++TV P F E P + +
Sbjct: 4214 GKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTE--LPGDVSL 4271
Query: 587 VEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAP---GIY 643
+G SC+ G P P + + ++P + + + ++ G Y
Sbjct: 4272 NKGEQLRLSCKATGIPLPKLTWTFNNN-----IIPAHFDSVNGHSELVIERVSKEDSGTY 4326
Query: 644 VCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASA-LACAARGRPSPGVRC 702
VC A N G V V + PP + PS+ W+E +A L C +G P+P ++
Sbjct: 4327 VCTAENSVGFVKAIGFVYVKEPPVF-KGDYPSN--WIEPLGGNAILNCEVKGDPTPTIQW 4383
Query: 703 SREGIPWPEQQRVSR-------------EDAGTYHCVATNAHGTDSRTVTVGVEYRPVVA 749
+R+G+ R+ + EDAG Y CVATN G R++++ ++ P++
Sbjct: 4384 NRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIIT 4443
Query: 750 ELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALN----IGLSSNNSTLSVAGAM 805
+ GG L C+A P I+W +++ + + SNNS L +A A
Sbjct: 4444 LEPVETV--INAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNS-LYIADAQ 4500
Query: 806 GSHGGEYECAATNAHGRHARRITVRV 831
E+EC A N G R+ V V
Sbjct: 4501 KEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 122 bits (305), Expect = 2e-27
Identities = 163/672 (24%), Positives = 254/672 (37%), Gaps = 99/672 (14%)
Query: 226 LSPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVAT 285
L +A + AP L + PVS +GL S R+ LAL +S + +
Sbjct: 2031 LECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRI-LALTSAQIS-----DTGRYTCV 2084
Query: 286 ATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCA 345
A A +Q R + V + +NV++ A L ++ T+T
Sbjct: 2085 AVNAAGEKQ---RDIDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPP---TLTWL 2138
Query: 346 AGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVL 405
L+ G+ ++ + L++ + D + C+AT +V G+T ++ + +
Sbjct: 2139 KDGHPLLKKPGL--SISENRSVLKIEDAQVQDTGRYTCEAT-NVAGKT---EKNYNVNIW 2192
Query: 406 YAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALS 465
P + SD T EG +L CE+ G P P++ + G+ + +G V R LS
Sbjct: 2193 VPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKK--GSPVLTDSMGRV-RILS 2249
Query: 466 G---------------TYRCKAANDQGEAVKDVTLTVEYAPALDSVGC-PERITWLEGTE 509
G Y C A+N G A K+ L V P + + G P I G
Sbjct: 2250 GGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKS 2309
Query: 510 ASLSCVAHGVPPPDVICVRSGELGAVIEG--------LLRVAREHA---GTYRCEATNPR 558
SL C G+PPP V ++ G +G +L++ H G Y C A N
Sbjct: 2310 ISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVA 2369
Query: 559 GSAAKNVAVTVEYGPRF-EEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEG 617
G K ++V P P N + VE + +CE G P PS+ G
Sbjct: 2370 GMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVS- 2428
Query: 618 VLLPLAPPDPSPRAPRIPRVLAP-----GIYVCNATNRHGSVAKTVVVSAESPPEM-DES 671
L+ R+ R++ G Y C N G K +S PP + E+
Sbjct: 2429 ----LSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGEN 2484
Query: 672 TCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQ--------------RVSR 717
T + ++ ++ L C G P P + ++G P E + V
Sbjct: 2485 TLEDVK--VKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQV 2542
Query: 718 EDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGN-----------FT 766
G Y C+A++ G SR+ ++ V P +A GV GN +
Sbjct: 2543 PHTGRYTCLASSPAGHKSRSFSLNVFVSPTIA--------GVGSDGNPEDVTVILNSPTS 2594
Query: 767 LTCRAEAWPPAQISWRAPPGAL----NIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGR 822
L C A ++PPA I+W L NI + TL + A + G Y C ATN G
Sbjct: 2595 LVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGE 2654
Query: 823 HARRITVRVAGP 834
+ V+V P
Sbjct: 2655 MIKHYEVKVYIP 2666
Score = 121 bits (303), Expect = 3e-27
Identities = 128/450 (28%), Positives = 184/450 (40%), Gaps = 61/450 (13%)
Query: 429 LRCEARGNPEPSVHCARSD--------GGAVLALGLLGPVTRAL---SGTYRCKAANDQG 477
L CEA G P P + + AVL G L ++RA+ +GTY C A N G
Sbjct: 4007 LPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGL-QISRAVREDAGTYMCVAQNPAG 4065
Query: 478 EAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIE 537
A+ + L V+ P + S E + ++ +LSC A G+PPPD+ + G A++E
Sbjct: 4066 TALGKIKLNVQVPPVI-SPHLKEYVIAVD-KPITLSCEADGLPPPDITWHKDGR--AIVE 4121
Query: 538 ---------GLLRVAREH---AGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWT 585
G L++A AG Y C A N GS++ + +TV PR S ++T
Sbjct: 4122 SIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIR--STEGHYT 4179
Query: 586 WVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLP--LAPPDPSPRAPRIPRVLA---P 640
E S + C DG P P++ + VLL L P I +
Sbjct: 4180 VNENSQAILPCVADGIPTPAINW-----KKDNVLLANLLGKYTAEPYGELILENVVLEDS 4234
Query: 641 GIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGV 700
G Y C A N G TV ++ P E P + +G E L+C A G P P +
Sbjct: 4235 GFYTCVANNAAGEDTHTVSLTVHVLPTFTE--LPGDVSLNKG-EQLRLSCKATGIPLPKL 4291
Query: 701 RCSREGIPWPEQ------------QRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVV 748
+ P +RVS+ED+GTY C A N+ G V V+ PV
Sbjct: 4292 TWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVF 4351
Query: 749 AELAASPPGGVRP-GGNFTLTCRAEAWPPAQISWRAPPGALNIG---LSSNNSTLSVAGA 804
P + P GGN L C + P I W + I N +L++ G
Sbjct: 4352 K--GDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGT 4409
Query: 805 MGSHGGEYECAATNAHGRHARRITVRVAGP 834
+ G+Y C ATN G R +++ + P
Sbjct: 4410 VNEDAGDYTCVATNEAGVVERSMSLTLQSP 4439
Score = 117 bits (294), Expect = 4e-26
Identities = 145/615 (23%), Positives = 233/615 (37%), Gaps = 99/615 (16%)
Query: 295 EGARQLVCNVTLGGENRETRENVTIYSFPA----PLLTLSEPSVSEGQMVTVTCAAGA-- 348
+G + GE+++ + ++T+Y P+ +LS +V EG V++ C + A
Sbjct: 3029 DGGEYTCIAINQAGESKK-KFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVP 3087
Query: 349 --------QALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSA 400
+ E + L + E D + C A ++V G +++
Sbjct: 3088 PPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRA-INVAGRD---DKNF 3143
Query: 401 ELRVLYAPRLDDSDCPRSWTWPEGPEQ-----------TLRCEARGNPEPSV-------H 442
L V P + EGPE+ TL C+A G P P++
Sbjct: 3144 HLNVYVPPSI------------EGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKR 3191
Query: 443 CARSDGGAVLAL--GLLGPVTRAL---SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVG 497
SD V L G + R+ SG Y C A+N +G+A K L+++ P++
Sbjct: 3192 IENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAE 3251
Query: 498 CPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAVIE-------------GLLRVAR 544
P ++ L G L C A+G+P P + ++ G+ A E +
Sbjct: 3252 IPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALT 3311
Query: 545 EHAGTYRCEATNPRGSAAK--NVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKP 602
G Y C ATNP G + N+ V V R + T V+ S + C G P
Sbjct: 3312 SDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINI-ECRATGTP 3370
Query: 603 QPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAP-----GIYVCNATNRHGSVAKT 657
P + + G+ LPL+ A ++ R++ +Y C A+NR G K
Sbjct: 3371 PPQINWL-----KNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKH 3425
Query: 658 VVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWP------- 710
+ +PP MD S T L+G+ S +AC G P+P + R+G P
Sbjct: 3426 YNLQVFAPPNMDNSMGTEEITVLKGSSTS-MACITDGTPAPSMAWLRDGQPLGLDAHLTV 3484
Query: 711 -------EQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGG 763
+ + ED+G Y C+A+N G S+ + V P + V
Sbjct: 3485 STHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNN 3544
Query: 764 NFTLTCRAEAWPPAQISW----RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNA 819
LTC A P +++W R P + L ++ A G Y C A++
Sbjct: 3545 PLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSP 3604
Query: 820 HGRHARRITVRVAGP 834
G + VRV P
Sbjct: 3605 AGDDDKEYLVRVHVP 3619
Score = 112 bits (281), Expect = 1e-24
Identities = 126/473 (26%), Positives = 178/473 (37%), Gaps = 78/473 (16%)
Query: 423 EGPEQTLRCEA-RGNPEPSVH--------------CARSDGGAVLALGLLGPVTRALSGT 467
EG + TL C GNP P RSDG + L G
Sbjct: 903 EGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQD-----GGE 957
Query: 468 YRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICV 527
Y C A+N G K ++ V P + + ++ +EG +L C A G P P VI
Sbjct: 958 YTCVASNVAGTNNKTTSVVVHVLPTIQHG--QQILSTIEGIPVTLPCKASGNPKPSVIWS 1015
Query: 528 RSGEL--------GAVIEGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFE 576
+ GEL A +G L V E +G Y C ATN G A + V +TV PR
Sbjct: 1016 KKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVF 1075
Query: 577 ------EPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAP-----P 625
P + + G CEV P P + + ++ P +P P
Sbjct: 1076 GDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPII----TWAKETQLISPFSPRHTFLP 1131
Query: 626 DPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEA 685
S + R G+Y+C ATN G+V + V ++ PP++ P H G
Sbjct: 1132 SGSMKITET-RTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQRG--PKHLKVQVGQRV 1188
Query: 686 SALACAARGRPSPGVRCSREG----------IPWPEQ----QRVSREDAGTYHCVATNAH 731
+ C A+G P P + S+ G + P+ + + DAG Y CVATN
Sbjct: 1189 D-IPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIA 1247
Query: 732 GTDSRTVTVGVEYRPVVAELAASPPGGVR-----PGGNFTLTCRAEAWPPAQISWRAPPG 786
GTD +T+ V+ P V +L PP C A+ P I W
Sbjct: 1248 GTDETEITLHVQEPPTVEDL--EPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGR 1305
Query: 787 AL-----NIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
L I + + + L +A GEY C A N G R+ ++V P
Sbjct: 1306 ELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVP 1358
Score = 111 bits (278), Expect = 3e-24
Identities = 163/676 (24%), Positives = 262/676 (38%), Gaps = 101/676 (14%)
Query: 225 SLSPDAPRLAAPRLLEVGSERP--VSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAF 282
S+ PDAP++ P +P + C++D L P + + V + L D L+ A
Sbjct: 425 SIVPDAPKVTMPEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGV---TLGVDQYLKESAS 481
Query: 283 VATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTL-SEPSVSEGQMVT 341
V A + EG + + + G +T +V S P P++ + + +V+ G+
Sbjct: 482 VNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDV---SEPPPVIQVPNNVTVTPGERAV 538
Query: 342 VTCAAGAQALVTL------EGVPAAVPGQ-----PAQLQLNATENDDRRSFFCDATLDVD 390
+TC + L V A P + L+L + + +D + C V
Sbjct: 539 LTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCM----VS 594
Query: 391 GETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSV--------- 441
E S L V P++ + P++ ++ G E ++ C A G P+P +
Sbjct: 595 SEGGSSAASVFLTVQEPPKV--TVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFI 652
Query: 442 ---HCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGC 498
H R L + P +G Y C A+N G ++ TL AP L V
Sbjct: 653 VGSHRYRMTSDGTLFIKNAAPKD---AGIYGCLASNSAGTDKQNSTLRYIEAPKLMVV-- 707
Query: 499 PERITWLEGTEASLSCVAHGVPPPDVICVRSGELG------AVIE---GLLRVAREH--- 546
+ G + C G+PPP V + G+L +I+ GLL++
Sbjct: 708 QSELLVALGDITVMECKTSGIPPPQVKWFK-GDLELRPSTFLIIDPLLGLLKIQETQDLD 766
Query: 547 AGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSV 606
AG Y C A N G A + + V P F + P++ + GS C V G P+P++
Sbjct: 767 AGDYTCVAINEAGRATGKITLDVGSPPVFIQE--PADVSMEIGSNVTLPCYVQGYPEPTI 824
Query: 607 KCVGSGGATEGVLLPLAPPDPSPRAPRIPRVL--------APGIYVCNATNRHGSVAK-- 656
K + + + P S + L G Y+C A N+ G +
Sbjct: 825 K----WRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSET 880
Query: 657 TVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQ---- 712
TV V+ P + S PS +EG + + G P P R + +
Sbjct: 881 TVTVTGLVAPLIGIS--PSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYIT 938
Query: 713 ---------QRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVV--AELAASPPGGVRP 761
+RV +D G Y CVA+N GT+++T +V V P + + S G+
Sbjct: 939 VRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQILSTIEGI-- 996
Query: 762 GGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAM------GSHGGEYECA 815
TL C+A P + W + G L I SS + G++ G GEY C
Sbjct: 997 --PVTLPCKASGNPKPSVIW-SKKGEL-ISTSSAKFSAGADGSLYVVSPGGEESGEYVCT 1052
Query: 816 ATNAHGRHARRITVRV 831
ATN G R++ + V
Sbjct: 1053 ATNTAGYAKRKVQLTV 1068
Score = 111 bits (278), Expect = 3e-24
Identities = 123/512 (24%), Positives = 196/512 (38%), Gaps = 60/512 (11%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
LQL E +D + C A+ + GE ++ L+VL P ++ S+ +
Sbjct: 3491 LQLLKAETEDSGKYTCIASNEA-GEV---SKHFILKVLEPPHINGSEEHEEISVIVNNPL 3546
Query: 428 TLRCEARGNPEPSVHCARSD-------------GGAVLALGLLGPVTRALSGTYRCKAAN 474
L C A G P P + + GG VL + +G Y C A++
Sbjct: 3547 ELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVED---TGRYTCLASS 3603
Query: 475 DQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGE-LG 533
G+ K+ + V P + P IT L + +L C + VPPP + +R+GE L
Sbjct: 3604 PAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQ 3663
Query: 534 A-----VIEG--LLRVAREHAG---TYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSN 583
A ++ G L++ G Y C A+N G + +TV P + P +
Sbjct: 3664 ATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIK--GGPQS 3721
Query: 584 WTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIY 643
+ + C +G P P + G G + + + V G Y
Sbjct: 3722 LVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRY 3781
Query: 644 VCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCS 703
+C ATN G+ + + + PP + + P++ T + + + LAC A G P P +
Sbjct: 3782 LCMATNAAGTDRRRIDLQVHVPPSI--APGPTNMTVIVNVQ-TTLACEATGIPKPSINWR 3838
Query: 704 REG--IPWPEQQRVSR--------------EDAGTYHCVATNAHGTDSRTVTVGVEYRPV 747
+ G + + Q R +D TY C TN G D RTV + V+ P
Sbjct: 3839 KNGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPS 3898
Query: 748 VAELAASPPGGVRPGGNFTLTCRAEAWPPAQISW-----RAPPGALNIGLSSNNSTLSVA 802
+A+ V +TC A P I W R P + S+ + + +
Sbjct: 3899 IAD--EPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGA-IEIL 3955
Query: 803 GAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
+H G Y C A NA G R +T+ V P
Sbjct: 3956 ATQLNHAGRYTCVARNAAGSAHRHVTLHVHEP 3987
Score = 103 bits (256), Expect = 1e-21
Identities = 132/563 (23%), Positives = 200/563 (35%), Gaps = 74/563 (13%)
Query: 334 VSEGQMVTVTCAAGAQALVTLE----GVPAAVPGQ------PAQLQLNATENDDRRSFFC 383
V GQ V + C A L + G V G+ L ++ D + C
Sbjct: 1182 VQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTC 1241
Query: 384 DATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPE---GPEQTLRCEARGNPEPS 440
AT ++ G L V P ++D + P + T+ E C A+G P+P+
Sbjct: 1242 VAT-NIAGTD---ETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPT 1297
Query: 441 VH--------CARSDGGAVLALGLL---GPVTRALSGTYRCKAANDQGEAVKDVTLTVEY 489
+ R G ++L G L VT +G Y C A N+ G + L V
Sbjct: 1298 IKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHV 1357
Query: 490 APALDSVGCPERITWLEGTEASLSCVAHGVPPP-------DVICVRSGELGAVIEG---- 538
P + ++ L +L C G P P +V S + V G
Sbjct: 1358 PPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILK 1417
Query: 539 LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEV 598
L R E AG Y C+A N G++ K + V P + P+ + V C+V
Sbjct: 1418 LFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQV 1477
Query: 599 DGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVL--------APGIYVCNATNR 650
G P P + G PL DP+ +VL G Y C +N
Sbjct: 1478 KGTPFPDIHWFKDG-------KPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 651 HGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIP-- 708
G AK + ++ PP + + + L + L C RG P P + ++G P
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINS-LIKLECETRGLPMPAITWYKDGQPIM 1589
Query: 709 ------------WPEQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPP 756
+ R D+ TY C N GT ++ V V P++ A+P
Sbjct: 1590 SSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPL 1649
Query: 757 G-GVRPGGNFTLTCRAEAWPPAQISWRAPPGAL----NIGLSSNNSTLSVAGAMGSHGGE 811
V + TL C+A P ++W + NI + + L + A G+
Sbjct: 1650 NKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQ 1709
Query: 812 YECAATNAHGRHARRITVRVAGP 834
Y C AT+ G + V V P
Sbjct: 1710 YICVATSVAGEKEIKYEVDVLVP 1732
Score = 97.1 bits (240), Expect = 7e-20
Identities = 116/469 (24%), Positives = 180/469 (38%), Gaps = 72/469 (15%)
Query: 424 GPEQTLRCEARGNPEPSVHCARSDG------------------GAVLALGLLGPVTRALS 465
G TL C +G PEP++ R D GA+ L L +
Sbjct: 807 GSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWA----SDK 862
Query: 466 GTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSC-VAHGVPPPD- 523
GTY C+A N G+ + T+TV A P +EG + +L C + G P P+
Sbjct: 863 GTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPER 922
Query: 524 ------VICVRSGELGAVIEGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVEYGPR 574
+ +++ + +G L + R + G Y C A+N G+ K +V V P
Sbjct: 923 RWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPT 982
Query: 575 FEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRI 634
+ + +EG C+ G P+PSV + +G L+ + S A
Sbjct: 983 IQHGQ--QILSTIEGIPVTLPCKASGNPKPSVI-----WSKKGELISTSSAKFSAGADGS 1035
Query: 635 PRVLAP-----GIYVCNATNRHGSVAKTVVVSAESPPEMD------ESTCPSHQTWLEGA 683
V++P G YVC ATN G + V ++ P + P + L G
Sbjct: 1036 LYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGE 1095
Query: 684 EASALACAARGRPSPGVRCSREG---IPWPEQQ-----------RVSREDAGTYHCVATN 729
E + L C + P P + ++E P+ + D+G Y CVATN
Sbjct: 1096 EVT-LPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN 1154
Query: 730 AHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALN 789
G ++ V + V P + V+ G + C A+ P I+W +
Sbjct: 1155 IAGNVTQAVKLNVHVPPKIQR--GPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTML 1212
Query: 790 IG----LSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
+ +S+ + TLS+ A S G Y C ATN G IT+ V P
Sbjct: 1213 VDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEP 1261
Score = 90.9 bits (224), Expect = 5e-18
Identities = 114/517 (22%), Positives = 182/517 (35%), Gaps = 64/517 (12%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L+L +D + C A +++ G + + + VL P + ++ P + +
Sbjct: 1416 LKLFRATPEDAGRYSCKA-INIAGTS---QKYFNIDVLVPPTIIGTNFPNEVSVVLNRDV 1471
Query: 428 TLRCEARGNPEPSVHCARS--------------DGGAVLALGLLGPVTRALSGTYRCKAA 473
L C+ +G P P +H + D G VL L R G Y+C +
Sbjct: 1472 ALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLK---NARRNDKGRYQCTVS 1528
Query: 474 NDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSG--- 530
N G+ KD+ LT+ P++ I+ L + L C G+P P + + G
Sbjct: 1529 NAAGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPI 1588
Query: 531 ---------ELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFE-EPSC 580
+ G + + R + TY C N G+A K+ V V P E +
Sbjct: 1589 MSSSQALYIDKGQYLH-IPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLAT 1647
Query: 581 PSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSG---GATEGVLLPLAPPD-PSPRAPRIPR 636
P N V C+ G P P + + G A + + + A I R
Sbjct: 1648 PLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDR 1707
Query: 637 VLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRP 696
G Y+C AT+ G V PP ++ S+ + L C G P
Sbjct: 1708 ----GQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVN-NLLELDCHVTGSP 1762
Query: 697 SPGVRCSREGIPWPEQQ--------------RVSREDAGTYHCVATNAHGTDSRTVTVGV 742
P + ++G E+ + + G Y C+A N G + V V
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 743 EYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGAL-----NIGLSSNNS 797
P + S V+ L C A P I+W + N+ + S+
Sbjct: 1823 HVPPTIKSSGLSERVVVK-YKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGR 1881
Query: 798 TLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
L +A + G Y C ATNA G + I + V P
Sbjct: 1882 VLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEP 1918
Score = 87.8 bits (216), Expect = 4e-17
Identities = 142/592 (23%), Positives = 203/592 (34%), Gaps = 106/592 (17%)
Query: 328 TLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAV---PGQPAQ-------------LQLN 371
TL + V E Q VT+TC VT VP GQP Q LQ+
Sbjct: 2485 TLEDVKVKEKQSVTLTCE------VTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQIT 2538
Query: 372 ATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRL---DDSDCPRSWTWPEGPEQT 428
+ + C A+ K+RS L V +P + P T +
Sbjct: 2539 NVQVPHTGRYTCLASSPAGH----KSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS 2594
Query: 429 LRCEARGNPEPSVHCARSDGGA--------VLALGLLGPVTRAL---SGTYRCKAANDQG 477
L CEA P ++ + DG +L G + A +G Y C A N+ G
Sbjct: 2595 LVCEAYSYPPATITWFK-DGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAG 2653
Query: 478 EAVKDVTLTVEYAPALDSVG-------CPERITWLEGTEASLSCVAHGVPPPDVICVRSG 530
E +K + V Y P + + G P+ + +L C A+ +P + + G
Sbjct: 2654 EMIKHYEVKV-YIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDG 2712
Query: 531 ELGAVIEGLLRVAREHA-----------GTYRCEATNPRGSAAKNVAVTVEYGPRFEEPS 579
+ + + A H G Y C A+N G + V ++ P F++
Sbjct: 2713 QPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLW 2772
Query: 580 CPSNWTWVEGSGRL----------FSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPD--- 626
N +G CE + P P++ G PL D
Sbjct: 2773 EIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGH-------PLTSSDKVL 2825
Query: 627 --PSPRAPRIPR--VLAPGIYVCNATNRHGSVAKTVVVSAESPPEMD--ESTCPSHQTWL 680
P R +IPR V G Y C A N G + V PP + S P T L
Sbjct: 2826 ILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVL 2885
Query: 681 EGAEASALACAARGRPSPGVRCSREGIPWPEQQR--------------VSREDAGTYHCV 726
A + C + G P+P ++G P E D G Y CV
Sbjct: 2886 VNKSA-LIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCV 2944
Query: 727 ATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISW--RAP 784
A N G+ + + V P V S V +LTC +PP +SW
Sbjct: 2945 AENTAGSAKKYFNLNVHVPPSVIG-PKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQ 3003
Query: 785 PGALNIG--LSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
P LN + TL + A S GGEY C A N G ++ ++ V P
Sbjct: 3004 PIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVP 3055
Score = 81.3 bits (199), Expect = 4e-15
Identities = 104/456 (22%), Positives = 162/456 (35%), Gaps = 68/456 (14%)
Query: 429 LRCEARGNPEPSVHCARSDGGAVLALGLLG--------PVTRAL---SGTYRCKAANDQG 477
L+C A G P PS+ + D A G L + + L +G Y C A N G
Sbjct: 1846 LQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAG 1905
Query: 478 EAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGEL----- 532
E + + L V P+L+ G T L L C A G P P + + L
Sbjct: 1906 ETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGST 1965
Query: 533 -------GAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWT 585
G +I+ + AG Y+C A N G+ ++ V P S +N
Sbjct: 1966 SMTFLNRGQIID-IESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSI---SGSNNMV 2021
Query: 586 WVEGSGRL-FSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLA----- 639
V + + CE G P PS+ + G P++ + R+LA
Sbjct: 2022 AVVVNNPVRLECEARGIPAPSLTWLKDGS-------PVSSFSNGLQVLSGGRILALTSAQ 2074
Query: 640 ---PGIYVCNATNRHGSVAKTVVVSAESPPE-MDESTCPSHQTWLEGAEASALACAARGR 695
G Y C A N G + + + PP M E S + ++A L C +
Sbjct: 2075 ISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVS----VLISQAVELLCQSDAI 2130
Query: 696 PSPGVRCSREGIPWPEQQRVS--------------REDAGTYHCVATNAHGTDSRTVTVG 741
P P + ++G P ++ +S +D G Y C ATN G + V
Sbjct: 2131 PPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVN 2190
Query: 742 VEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGAL------NIGLSSN 795
+ P + V G +L C + PP + W+ + + + S
Sbjct: 2191 IWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSG 2250
Query: 796 NSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRV 831
L ++ A S Y C A+N G + ++V
Sbjct: 2251 GRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQV 2286
Score = 79.3 bits (194), Expect = 1e-14
Identities = 125/540 (23%), Positives = 190/540 (35%), Gaps = 80/540 (14%)
Query: 361 VPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDC----- 415
+PG LNA E++ R + C AT + GE + + E++V P ++ D
Sbjct: 2625 LPGGRTLQILNAQEDNAGR-YSCVATNEA-GEMI---KHYEVKVYIPPIINKGDLWGPGL 2679
Query: 416 -PRSWTWPEGPEQTLRCEARGNPEPSVHCARS-------DGGAVLALGLLGPVTRAL--- 464
P+ TL CEA P S+ + D + A G + A
Sbjct: 2680 SPKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISD 2739
Query: 465 SGTYRCKAANDQGEAVKDVTLTVEYAPA----------LDSVGCPERITWLEGTEASLSC 514
+G Y C A+N GE D + ++ P+ LD+ E + SL C
Sbjct: 2740 TGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYC 2799
Query: 515 VAHGVPPPDVICVRSGEL-----------GAVIEGLLRVAREHAGTYRCEATNPRGSAAK 563
+ PPP + + G G + + R E AG Y C A N G +
Sbjct: 2800 ETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSL 2859
Query: 564 NVAVTVEYGPRFE--EPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLP 621
V V P + P T + L C G P P G P
Sbjct: 2860 QYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQ-------P 2912
Query: 622 LAPPDPSPRAP--RIPRVLAP-----GIYVCNATNRHGSVAKTVVVSAESPPEMDESTCP 674
L D RI ++L G YVC A N GS K ++ PP +
Sbjct: 2913 LLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPK-- 2970
Query: 675 SHQTWLEGAEASALACAARGRPSPGVRCSREG-----------IPWPEQQRVSR---EDA 720
S + +L C G P P + + +P ++ R D
Sbjct: 2971 SENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDG 3030
Query: 721 GTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPG--GVRPGGNFTLTCRAEAWPPAQ 778
G Y C+A N G + ++ V P + + + VR G + +L C + A PP
Sbjct: 3031 GEYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPV 3090
Query: 779 ISW----RAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
I+W R + ++ + ++ L + A S G+Y C A N GR + + V P
Sbjct: 3091 ITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVP 3150
Score = 76.3 bits (186), Expect = 1e-13
Identities = 97/423 (22%), Positives = 148/423 (34%), Gaps = 68/423 (16%)
Query: 457 LGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVA 516
+ VT + G Y C A + G V P + V P +T G A L+C+
Sbjct: 486 IAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQV--PNNVTVTPGERAVLTCLI 543
Query: 517 HGVPPPDVICVRSGE------------LGAVIEGLLRVAREHAGTYRCEATNPRGSAAKN 564
++ R+ L + L V AG Y C ++ GS+A +
Sbjct: 544 ISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAAS 603
Query: 565 VAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVK-------CVGSGG---A 614
V +TV+ P+ P N ++ GS C G P+P + VGS
Sbjct: 604 VFLTVQEPPKV--TVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMT 661
Query: 615 TEGVLL--PLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDEST 672
++G L AP D GIY C A+N G+ + + P++
Sbjct: 662 SDGTLFIKNAAPKD-------------AGIYGCLASNSAGTDKQNSTLRYIEAPKL---M 705
Query: 673 CPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQ--------------QRVSRE 718
+ + + + + C G P P V+ + + Q
Sbjct: 706 VVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDL 765
Query: 719 DAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQ 778
DAG Y CVA N G + +T+ V PV + A + G N TL C + +P
Sbjct: 766 DAGDYTCVAINEAGRATGKITLDVGSPPVFIQEPADV--SMEIGSNVTLPCYVQGYPEPT 823
Query: 779 ISWR--------APPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVR 830
I WR + P +++ L + S G Y C A N G+ TV
Sbjct: 824 IKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVT 883
Query: 831 VAG 833
V G
Sbjct: 884 VTG 886
Score = 67.0 bits (162), Expect = 8e-11
Identities = 57/222 (25%), Positives = 96/222 (43%), Gaps = 36/222 (16%)
Query: 641 GIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGV 700
G Y C ++ GS A +V ++ + PP++ + P +Q++ G+E S + C+A G P P +
Sbjct: 587 GEYHCMVSSEGGSSAASVFLTVQEPPKV--TVMPKNQSFTGGSEVSIM-CSATGYPKPKI 643
Query: 701 ---------------RCSREGIPWPEQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYR 745
R + +G + + + +DAG Y C+A+N+ GTD + T+
Sbjct: 644 AWTVNDMFIVGSHRYRMTSDGTLFIKN--AAPKDAGIYGCLASNSAGTDKQNSTLRYIEA 701
Query: 746 P----VVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISW-----RAPPGALNIGLSSNN 796
P V +EL V G + C+ PP Q+ W P I +
Sbjct: 702 PKLMVVQSELL------VALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLI-IDPLL 754
Query: 797 STLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWV 838
L + G+Y C A N GR +IT+ V P +++
Sbjct: 755 GLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFI 796
Score = 61.2 bits (147), Expect = 4e-09
Identities = 75/316 (23%), Positives = 122/316 (38%), Gaps = 44/316 (13%)
Query: 293 EQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALV 352
E G V N GE+ T ++T++ P + S+++G+ + ++C A L
Sbjct: 4232 EDSGFYTCVAN-NAAGEDTHT-VSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLP 4289
Query: 353 TLEG------VPA---AVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELR 403
L +PA +V G ++L + +D ++ C A V I
Sbjct: 4290 KLTWTFNNNIIPAHFDSVNGH-SELVIERVSKEDSGTYVCTAENSVGFVKAIG-----FV 4343
Query: 404 VLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSV------------HCARSDGGAV 451
+ P + D P +W P G L CE +G+P P++ H R G
Sbjct: 4344 YVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS 4403
Query: 452 LALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEAS 511
LA + G V +G Y C A N+ G + ++LT++ P + P G +
Sbjct: 4404 LA--IYGTVNED-AGDYTCVATNEAGVVERSMSLTLQSPPIITLE--PVETVINAGGKII 4458
Query: 512 LSCVAHGVPPPDVICVRSG-------ELGAVIEGLLRVA---REHAGTYRCEATNPRGSA 561
L+C A G P P + R G + + L +A +E + C A N GS
Sbjct: 4459 LNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSV 4518
Query: 562 AKNVAVTVEYGPRFEE 577
V V V+ F +
Sbjct: 4519 LVRVPVIVQVHGGFSQ 4534
Score = 60.8 bits (146), Expect = 5e-09
Identities = 97/436 (22%), Positives = 158/436 (36%), Gaps = 82/436 (18%)
Query: 221 LRTFSLSPDAPRLAAPRLLE--VGSERPV--SCTLDGLFPASEARVYLALGDQNLSPDVT 276
L L+ P + +P L E + ++P+ SC DGL P PD+T
Sbjct: 4068 LGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEADGLPP----------------PDIT 4111
Query: 277 LEGDAFVATATATASAEQEGARQLV-----------CNVTLGGENRETRENVTIYSFPAP 325
D + G+ Q+ C + T +T++ P
Sbjct: 4112 WHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRI 4171
Query: 326 LLTLSEPSVSEGQMVTVTCAAGA---------QALVTLEGVPAAVPGQP-AQLQLNATEN 375
T +V+E + C A + V L + +P +L L
Sbjct: 4172 RSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVL 4231
Query: 376 DDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARG 435
+D + C A +T + L V P ++ P + +G + L C+A G
Sbjct: 4232 EDSGFYTCVANNAAGEDT----HTVSLTVHVLPTF--TELPGDVSLNKGEQLRLSCKATG 4285
Query: 436 NPEPSV-----------HCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVT 484
P P + H +G + L ++ V++ SGTY C A N G VK +
Sbjct: 4286 IPLPKLTWTFNNNIIPAHFDSVNGHSEL---VIERVSKEDSGTYVCTAENSVG-FVKAIG 4341
Query: 485 LTVEYAPALDSVGCPERITWLE--GTEASLSCVAHGVPPPDVICVRSG----------EL 532
P + P W+E G A L+C G P P + R G +L
Sbjct: 4342 FVYVKEPPVFKGDYPSN--WIEPLGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQL 4399
Query: 533 GAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFE-EPSCPSNWTWVEGSG 591
G + E AG Y C ATN G +++++T++ P EP T + G
Sbjct: 4400 GNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPV----ETVINAGG 4455
Query: 592 RLF-SCEVDGKPQPSV 606
++ +C+ G+PQP++
Sbjct: 4456 KIILNCQATGEPQPTI 4471
Score = 48.1 bits (113), Expect = 4e-05
Identities = 35/133 (26%), Positives = 61/133 (45%), Gaps = 8/133 (6%)
Query: 711 EQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCR 770
E + V DAG YHC+ ++ G+ + +V + V+ P V + + G ++ C
Sbjct: 577 ELKSVKFNDAGEYHCMVSSEGGSSAASVFLTVQEPPKVTVMPKNQ--SFTGGSEVSIMCS 634
Query: 771 AEAWPPAQISWRAPP----GALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARR 826
A +P +I+W G+ ++S + TL + A G Y C A+N+ G +
Sbjct: 635 ATGYPKPKIAWTVNDMFIVGSHRYRMTS-DGTLFIKNAAPKDAGIYGCLASNSAGTDKQN 693
Query: 827 ITVR-VAGPWLWV 838
T+R + P L V
Sbjct: 694 STLRYIEAPKLMV 706
Score = 37.7 bits (86), Expect = 0.050
Identities = 28/126 (22%), Positives = 50/126 (39%), Gaps = 7/126 (5%)
Query: 714 RVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEA 773
+V+ D G Y C+A ++ GT V P V ++ + V PG LTC +
Sbjct: 488 KVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVT--VTPGERAVLTCLIIS 545
Query: 774 WPPAQISWRAPPGALNIGLSSN-----NSTLSVAGAMGSHGGEYECAATNAHGRHARRIT 828
++W+ + + + N +L + + GEY C ++ G A +
Sbjct: 546 AVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASVF 605
Query: 829 VRVAGP 834
+ V P
Sbjct: 606 LTVQEP 611
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 118 bits (295), Expect = 3e-26
Identities = 184/760 (24%), Positives = 281/760 (36%), Gaps = 121/760 (15%)
Query: 135 GENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGA 194
G+ L+C VPG A +T RG R G R L D G
Sbjct: 2939 GQTLDLNCVVPGQA-HAQVTW-YKRGGSLPARHQTHGSQLRLH--------LVSPADSG- 2987
Query: 195 NFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLAAPR-LLEVGSERPVSCTL-D 252
+ CRA P F + P E ++ L + P ++ G + C + D
Sbjct: 2988 EYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHD 3047
Query: 253 GLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRE 312
G P S + +Q L +V + + + T T + G + V + G +
Sbjct: 3048 GAAPIS---LEWKTRNQELEDNVHISPNGSIITIVGTRPSNH-GTYRCVASNAYGVA--Q 3101
Query: 313 TRENVTIYSFPAPLLTLSEPS-VSEGQMVTVTCAAGAQALVT-----LEGVPAAVPGQP- 365
+ N++++ P + P V G+ VT+ C + + + + PA + +
Sbjct: 3102 SVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTY 3161
Query: 366 ------AQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLY--------APRLD 411
A LQ+++ + D ++ C A + + ++ V+ AP++
Sbjct: 3162 GLMDSHAVLQISSAKPSDAGTYVCLA------QNALGTAQKQVEVIVDTGAMAPGAPQVQ 3215
Query: 412 DSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCA----------RSDGGAVLALGLLGPVT 461
+ T G TLRC A G+P P++H + R +G ++ + V
Sbjct: 3216 AEEA--ELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLI----IPRVA 3269
Query: 462 RALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPP 521
+ SG Y C A + G A + L VE P +V PE + G L C+AHG PP
Sbjct: 3270 QQDSGQYICNATSPAGHAEATIILHVESPPYATTV--PEHASVQAGETVQLQCLAHGTPP 3327
Query: 522 PDVICVRSGELGAVIEGLL----------RVAREHAGTYRCEATNPRGSAAKNVAVTVEY 571
+ + +G+ + G R A E +G YRC TN GSA + V+
Sbjct: 3328 ---LTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQ- 3383
Query: 572 GPRFEEPSC-------------PSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGV 618
GP P+ P T G+ F C V ++ GG
Sbjct: 3384 GPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQL--- 3440
Query: 619 LLPLAPPDPSPR--APRIPRV--LAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCP 674
PP S + RI + G Y+C A G + + ++ P + +
Sbjct: 3441 -----PPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRT 3495
Query: 675 SHQTWLEGAEASALACAARGRPSPGVRCSREG---IPWPEQQ-------RVSREDAGTYH 724
S QT + G A C A G P P V S+ G P Q V DAG Y
Sbjct: 3496 SVQTVVVG-HAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYR 3554
Query: 725 CVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVR-PGGNFTL-TCRAEAWPPAQISWR 782
C ATNA GT V + V+ P + S P VR P G+ + C A +P ISW
Sbjct: 3555 CTATNAAGTTQSHVLLLVQALPQI-----SMPQEVRVPAGSAAVFPCIASGYPTPDISWS 3609
Query: 783 APPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGR 822
G+L N+ L + G Y C ATN G+
Sbjct: 3610 KLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
Score = 103 bits (256), Expect = 1e-21
Identities = 141/568 (24%), Positives = 206/568 (36%), Gaps = 78/568 (13%)
Query: 331 EPS---VSEGQMVTVTCAAGAQALVTLE------GVPAAVPGQPAQLQLNATENDDRRSF 381
EPS V+EGQ + + C QA + +PA L+LN D +
Sbjct: 2832 EPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEY 2891
Query: 382 FCDATLD---VDGETLIKNRSAELRVLYAPRLDDSDC--PRSWTWPEGPEQTLRCEARGN 436
C T ++ L+ + + AP L S EG L C G
Sbjct: 2892 SCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQ 2951
Query: 437 PEPSVHCARSDG---------GAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTV 487
V + G G+ L L L+ P A SG Y C+AA+ G ++ + TV
Sbjct: 2952 AHAQVTWYKRGGSLPARHQTHGSQLRLHLVSP---ADSGEYVCRAASGPGPE-QEASFTV 3007
Query: 488 EYAPALDSVGC---------PERITWLEGTEASLSCVAHGVPPPDVI--CVRSGEL---- 532
P+ S P T +G +AS C+ H P + R+ EL
Sbjct: 3008 TVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNV 3067
Query: 533 -----GAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWV 587
G++I ++ + GTYRC A+N G A V ++V P P WV
Sbjct: 3068 HISPNGSIIT-IVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV--LPEGPVWV 3124
Query: 588 E-GSGRLFSCEVDGKPQPSVKCVGSGGA-------TEGVLLPLAPPDPSPRAPRIPRVLA 639
+ G C G+P+ S + T G++ A S P
Sbjct: 3125 KVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPS-----D 3179
Query: 640 PGIYVCNATNRHGSVAKTVVVSAES---PPEMDESTCPSHQTWLEGAEASALACAARGRP 696
G YVC A N G+ K V V ++ P + + +E + L C+A G P
Sbjct: 3180 AGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSP 3239
Query: 697 SPGVRCS--REGIPWPEQ--------QRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRP 746
+P + S R +PW + RV+++D+G Y C AT+ G T+ + VE P
Sbjct: 3240 APTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPP 3299
Query: 747 VVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMG 806
+ V+ G L C A PP W +L ++ N L A
Sbjct: 3300 YATTVPEH--ASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAP 3357
Query: 807 SHGGEYECAATNAHGRHARRITVRVAGP 834
G Y C TN G + V GP
Sbjct: 3358 EDSGRYRCRVTNKVGSAEAFAQLLVQGP 3385
Score = 90.5 bits (223), Expect = 6e-18
Identities = 155/632 (24%), Positives = 221/632 (34%), Gaps = 125/632 (19%)
Query: 299 QLVCNVTLGGENRETRENVTIYS---------FPAPLLTLSEPSVSEGQMVTVTC--AAG 347
+ VC+V+ G +RET VTI P + S P+V EGQ + + C A
Sbjct: 2597 EYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQ 2656
Query: 348 AQALVTLEGVPAAVPGQ----PAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELR 403
QA++T ++P + + L+L+ D + C A ++D A +
Sbjct: 2657 PQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDA------LEASIV 2710
Query: 404 VLYAPRLDDSDCPRSWTWP-----------EGPEQTLRC------------EARGNPEPS 440
+ +P P S + P EG L C RG PS
Sbjct: 2711 ISVSPSAGSPSAPGS-SMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS 2769
Query: 441 VHCARSDGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEY----------- 489
H R G+ L L + P A SG Y C+ G V +T+E
Sbjct: 2770 HHQTR---GSRLRLHHVSP---ADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAP 2823
Query: 490 --APALDSVGCPERITWLEGTEASLSCVAHGVPPPDVIC-VRSGELGA---VIEGLLR-- 541
AP + R+ EG L CV G V R G L A V LLR
Sbjct: 2824 GGAPPIRIEPSSSRVA--EGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLN 2881
Query: 542 -VAREHAGTYRCEATNPRGSAAKNVAVTVE-------YGPRFEEPSC--PSNWTWVEGSG 591
V+ +G Y C+ T G+ +V VT+E P +P S+ EG
Sbjct: 2882 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2941
Query: 592 RLFSCEVDGKPQPSVKCVGSGGA------TEGVLLPLAPPDPSPRAPRIPRVLAPGIYVC 645
+C V G+ V GG+ T G L L P+ G YVC
Sbjct: 2942 LDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPAD----------SGEYVC 2991
Query: 646 NATNRHGSVAKTVVVSAESPPEMDE--------STCPSHQTWLEGAEASALACAARGRPS 697
A + G + P E S P T +G +AS G
Sbjct: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
Query: 698 PGVRCSREGIPWPEQQRVSREDA------------GTYHCVATNAHGTDSRTVTVGVEYR 745
+ + +S + GTY CVA+NA+G V + V
Sbjct: 3052 ISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
Query: 746 PVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISW---RAPPGAL---NIGLSSNNSTL 799
P V+ L P V+ G TL C + P + W + P L GL +++ L
Sbjct: 3112 PTVSVLPEGPV-WVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVL 3170
Query: 800 SVAGAMGSHGGEYECAATNAHGRHARRITVRV 831
++ A S G Y C A NA G +++ V V
Sbjct: 3171 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIV 3202
Score = 86.7 bits (213), Expect = 9e-17
Identities = 136/567 (23%), Positives = 208/567 (36%), Gaps = 100/567 (17%)
Query: 324 APLLTLSEP--SVSEGQMVTVTCAAGAQALVTLEG-------VPAAVPGQPAQLQLNATE 374
AP++++ P +V GQ+ C+A TLE +PA L+L A E
Sbjct: 1865 APVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVE 1924
Query: 375 NDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEAR 434
D+ + C A + + + PR+ S P G L C A
Sbjct: 1925 PTDQAQYLCRAHSSAGQQ--VARAVLHVHGGGGPRVQVS--PERTQVHAGRTVRLYCRAA 1980
Query: 435 GNPEPSVHCARSDGGAV----------LALGLLGPVTRALSGTYRCKAANDQGEAVKDVT 484
G P ++ R +GG++ +A L+ +T A +G Y C A + G A +
Sbjct: 1981 GVPSATITW-RKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQ 2039
Query: 485 LTVEYAPALDSVGCPERI-----TWLEGTEASLSCVAHGVPPPDVICVRSGELGAV---- 535
+ V A D+ P +I + EG L+CV G V R G G++
Sbjct: 2040 VVV--LSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRG--GSLPPHT 2095
Query: 536 -IEG----LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSC---------- 580
+ G L +V+ +G Y C N G ++ V+V +G PS
Sbjct: 2096 QVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTH-SGPSYTPVPGSTRPI 2154
Query: 581 ---PSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA------TEGVLLPLAPPDPSPRA 631
PS+ EG +C V G+ V GG+ T G LL L P+
Sbjct: 2155 RIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADS- 2213
Query: 632 PRIPRVLAPGIYVCNATNRHGSVAKTVVVSAES-------PPEMDESTCPSHQTWLEGAE 684
G YVC+ G + +V+V+ E+ PP ES S T EG +
Sbjct: 2214 ---------GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIES---SSSTVAEG-Q 2260
Query: 685 ASALACAARGRPSPGVRCSREGIPWPEQQRV----------SREDAGTYHCVATNAHGTD 734
L+C G+ V + G P + +V S DAG Y C A+N
Sbjct: 2261 TLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEAS 2320
Query: 735 SRTVTVGVEYRPVVAELAASPPGGVRP-------GGNFTLTCRAEAWPPAQISWRAPPGA 787
G + + ++ P + P G L C AQ++W G+
Sbjct: 2321 ITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGS 2380
Query: 788 LNIGLSSNNSTLSVAGAMGSHGGEYEC 814
L + ++ S L + A + GEY C
Sbjct: 2381 LPVRHQTHGSLLRLYQASPADSGEYVC 2407
Score = 85.1 bits (209), Expect = 3e-16
Identities = 114/468 (24%), Positives = 164/468 (35%), Gaps = 80/468 (17%)
Query: 422 PEGPEQTLRCEARGNPEPSVHCARSDG------------GAVLALGLLGPVTRALSGTYR 469
P+G +LRC+ G+P + +R DG G+ L + P +G Y
Sbjct: 1689 PQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSD---AGVYI 1745
Query: 470 CKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLE--------GTEASLSCVAHGVPP 521
C N L V AP+ P +T E G + + C A P
Sbjct: 1746 CTCRNLHQSNTSRAELLVTEAPSK-----PITVTVEEQRSQSVRPGADVTFICTAKSKSP 1800
Query: 522 PDVIC---VRSGEL---GAVIEGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVEYG 572
+ + +G+L G+L + AGTY C +N + V+
Sbjct: 1801 AYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS 1860
Query: 573 PRFEEPSC---PSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGAT-------EGVLLPL 622
P P T G F C G P P+++ G G G +L L
Sbjct: 1861 GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRL 1920
Query: 623 APPDPSPRAPRIPRVLAPGIYVCNATNRHGS-VAKTVV-VSAESPPEMDESTCPSHQTWL 680
+P+ +A Y+C A + G VA+ V+ V P + S +T +
Sbjct: 1921 PAVEPTDQAQ----------YLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP---ERTQV 1967
Query: 681 EGAEASALACAARGRPSPGVRCSREGIPWPEQQRVSRED-------------AGTYHCVA 727
L C A G PS + +EG P Q R R D AG Y CVA
Sbjct: 1968 HAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVA 2027
Query: 728 TNAHGTDSRTVTVGV----EYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRA 783
T+ GT + V V + P ++ +S P V G L C AQ++W
Sbjct: 2028 TSPAGTAQARIQVVVLSASDASPPPVKIESSSPS-VTEGQTLDLNCVVAGSAHAQVTWYR 2086
Query: 784 PPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRV 831
G+L + S L + + GEY C N G ITV V
Sbjct: 2087 RGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
Score = 85.1 bits (209), Expect = 3e-16
Identities = 140/576 (24%), Positives = 214/576 (37%), Gaps = 77/576 (13%)
Query: 120 PDRVELMPLPP-WQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEPPRARG 178
P V ++P P W VG+ TL C V PR+S T + + + R G
Sbjct: 3111 PPTVSVLPEGPVWVKVGKAVTLEC-VSAGEPRSSARWTRISSTPAKLEQ-------RTYG 3162
Query: 179 AVLTATVL----ARREDHGANFSCRAELDLRPHGLGLFENSSAPRELRTFSLSPDAPRLA 234
+ + VL A+ D G + C A+ + LG + + T +++P AP++
Sbjct: 3163 LMDSHAVLQISSAKPSDAGT-YVCLAQ-----NALGTAQKQ-VEVIVDTGAMAPGAPQVQ 3215
Query: 235 APRL---LEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATAS 291
A +E G + C+ G + ++ + L LEGD + A
Sbjct: 3216 AEEAELTVEAGHTATLRCSATG---SPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVA--- 3269
Query: 292 AEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQAL 351
Q+ + Q +CN T + E + + S P SV G+ V + C A
Sbjct: 3270 --QQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPP 3327
Query: 352 VTLEG--VPAAVPGQPAQ----LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVL 405
+T + V +++PG+ L +D + C T V A+L V
Sbjct: 3328 LTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAF----AQLLVQ 3383
Query: 406 YAP-RLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCA-RSDGGAVLAL----GLLGP 459
P L + P T L ++ G HCA SD G L G L P
Sbjct: 3384 GPPGSLPATSIPAGSTPTVQVTPQLETKSIG-ASVEFHCAVPSDRGTQLRWFKEGGQLPP 3442
Query: 460 -------------VTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLE 506
+ ++ GTY C+A G+A L ++ P++ T +
Sbjct: 3443 GHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV 3502
Query: 507 GTEASLSCVAHGVPPPDVICVRSG--------ELGAVIEGLLRVAREHAGTYRCEATNPR 558
G C+A G P P V + G + G V+ + V AG YRC ATN
Sbjct: 3503 GHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVR-IAHVELADAGQYRCTATNAA 3561
Query: 559 GSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGV 618
G+ +V + V+ P+ S P GS +F C G P P + S +G
Sbjct: 3562 GTTQSHVLLLVQALPQI---SMPQEVRVPAGSAAVFPCIASGYPTPDI----SWSKLDGS 3614
Query: 619 LLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSV 654
L P + + + R G YVC ATNR G V
Sbjct: 3615 LPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKV 3650
Score = 78.2 bits (191), Expect = 3e-14
Identities = 147/611 (24%), Positives = 208/611 (34%), Gaps = 93/611 (15%)
Query: 301 VCNVTLGGENRETRENVTIYSF----PAPL-LTLSEPSVSEGQMVTVTC--AAGAQALVT 353
+C T + R V + S P P+ + S PSV+EGQ + + C A A A VT
Sbjct: 2024 LCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2083
Query: 354 LEGVPAAVPGQP----AQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPR 409
++P ++L+L D + C V+ + K S + VL+
Sbjct: 2084 WYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCR----VENGSGPKEASITVSVLHGTH 2139
Query: 410 LDDSDCP------------RSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVL----- 452
S P S EG L C G V + G
Sbjct: 2140 SGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH 2199
Query: 453 -ALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERI-----TWLE 506
+L L VT A SG Y C G V +T+E A + P RI T E
Sbjct: 2200 GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIE-ASVIPGPIPPVRIESSSSTVAE 2258
Query: 507 GTEASLSCVAHGVPPPDVICV-RSGELGA--VIEG----LLRVAREHAGTYRCEATNPRG 559
G LSCV G V R G L A + G + + + AG Y C A+N
Sbjct: 2259 GQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGM- 2317
Query: 560 SAAKNVAVTVEYGPRFEEPSC--------PSNWTWVEGSGRLFSCEVDGKPQPSVKCVGS 611
A+ V VT G P+ PS+ EG +C V G+ V
Sbjct: 2318 EASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR 2377
Query: 612 GGA------TEGVLLPLAPPDPSPRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESP 665
GG+ T G LL L P+ + RVL + + SV T+ + P
Sbjct: 2378 GGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPL------EASVLVTIEPAGSVP 2431
Query: 666 PEMDESTCPSHQTWLEGAEASALA--CAARGRPSPGVRCSREGIPWPEQQRV-------- 715
T + + AE L C G+ V + G P + +V
Sbjct: 2432 ALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLL 2491
Query: 716 --SREDAGTYHCVATNAHGTDSRTVTVGVEYR-----------PVVAELAASPPGGVRPG 762
+ D+G Y C + GT +V V ++ R PV E S + G
Sbjct: 2492 QVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIE---SSSASLANG 2548
Query: 763 GNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGR 822
L C + P I+W G+L S L + + GEY C +N G
Sbjct: 2549 HTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGS 2608
Query: 823 HARRITVRVAG 833
+ V + G
Sbjct: 2609 RETSLIVTIQG 2619
Score = 77.4 bits (189), Expect = 6e-14
Identities = 116/473 (24%), Positives = 161/473 (34%), Gaps = 72/473 (15%)
Query: 416 PRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGG----------AVLALGLLGPVTRALS 465
P T G RC A G+P P++ GG +L L + P +A
Sbjct: 1872 PPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQA-- 1929
Query: 466 GTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVP----- 520
Y C+A + G+ V L V PER G L C A GVP
Sbjct: 1930 -QYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATIT 1988
Query: 521 --------PPDVICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYG 572
PP R+ +I + AG Y C AT+P G+A + V V
Sbjct: 1989 WRKEGGSLPPQARSERTDIATLLIPA---ITTADAGFYLCVATSPAGTAQARIQVVVLSA 2045
Query: 573 PRFEEPSCP---SNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSP 629
P S+ + EG +C V G V GG+ PP
Sbjct: 2046 SDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL--------PPHTQV 2097
Query: 630 RAPRI--PRVLAP--GIYVCNATNRHG----SVAKTVVVSAESPPE---MDESTCPSH-- 676
R+ P+V G YVC N G S+ +V+ S P + ST P
Sbjct: 2098 HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIE 2157
Query: 677 --QTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQR----------VSREDAGTYH 724
+ + + L C G+ V + G P + + V+ D+G Y
Sbjct: 2158 PSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYV 2217
Query: 725 CVATNAHGTDSRTVTVGVEYR----PVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQIS 780
C G +V V +E P+ S V G L+C AQ++
Sbjct: 2218 CHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVT 2277
Query: 781 WRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAG 833
W G+L S L + A + G+Y C A+N G A ITV V G
Sbjct: 2278 WYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEA-SITVTVTG 2327
Score = 72.8 bits (177), Expect = 1e-12
Identities = 136/609 (22%), Positives = 210/609 (34%), Gaps = 115/609 (18%)
Query: 330 SEPSVSEGQMVTVTCAAGAQALVTLEG-------------------VPAAVPGQPAQLQL 370
S S++ G + + C +QA T+ +P P +
Sbjct: 2541 SSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVC 2600
Query: 371 NATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLR 430
+ + R T+ G + + + S +R+ +S P T EG L
Sbjct: 2601 HVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRI-------ESSSP---TVVEGQTLDLN 2650
Query: 431 CEARGNPEPSVHCARSDGGAVLALGLLGPVTR------ALSGTYRCKAANDQGEAVKDVT 484
C P+ + + G G R A SG Y C+A N+ +
Sbjct: 2651 CVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIV 2710
Query: 485 LTVEYA---PALDSVGCPERITW-----LEGTEASLSCVAHGVPPPDVIC-VRSGELGAV 535
++V + P+ P RI EG L+CV G V R G L +
Sbjct: 2711 ISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSH 2770
Query: 536 IEG------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYG---------PRFEEPSC 580
+ L V+ +G Y C G +V VT+E P P
Sbjct: 2771 HQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIR 2830
Query: 581 --PSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGG------ATEGVLLPLAPPDPSPRAP 632
PS+ EG C V G+ V GG G LL L P+
Sbjct: 2831 IEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADS-- 2888
Query: 633 RIPRVLAPGIYVCNATNRHGSVAKTVVVSAE-SPPEMDESTCPSHQTWLEGAEASA---- 687
G Y C T G++ +V+V+ E S P + + ++E + +
Sbjct: 2889 --------GEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ 2940
Query: 688 ---LACAARGRPSPGVRCSREGIPWPEQQR----------VSREDAGTYHCVATNAHGTD 734
L C G+ V + G P + + VS D+G Y C A + G +
Sbjct: 2941 TLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE 3000
Query: 735 ---SRTVTV----GVEYRPVVAELAASPPGG-VRPGGNFTLTCRA-EAWPPAQISWRAPP 785
S TVTV G YR ++ PP V+ G + + C + P + W+
Sbjct: 3001 QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN 3060
Query: 786 GAL--NIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP--------- 834
L N+ +S N S +++ G S+ G Y C A+NA+G + + V GP
Sbjct: 3061 QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG 3120
Query: 835 WLWVAVGGA 843
+WV VG A
Sbjct: 3121 PVWVKVGKA 3129
Score = 61.6 bits (148), Expect = 3e-09
Identities = 141/621 (22%), Positives = 200/621 (32%), Gaps = 102/621 (16%)
Query: 291 SAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLS--EPSVSEGQMVTVTCAAGA 348
+ E Q +C + R + ++ P + +S V G+ V + C A
Sbjct: 1922 AVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAG 1981
Query: 349 --QALVTLEGVPAAVPGQP-------AQLQLNATENDDRRSFFCDATLDVDGETLIKNRS 399
A +T ++P Q A L + A D + C AT
Sbjct: 1982 VPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAG------TAQ 2035
Query: 400 AELRVLYAPRLDDSDCP-----RSWTWPEGPEQTLRCEARGNPEPSVHCARSDG------ 448
A ++V+ D S P S + EG L C G+ V R G
Sbjct: 2036 ARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHT 2095
Query: 449 ---GAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTV--------EYAPALDSVG 497
G+ L L + P A SG Y C+ N G +T++V Y P S
Sbjct: 2096 QVHGSRLRLPQVSP---ADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTR 2152
Query: 498 C----PERITWLEGTEASLSCVAHGVPPPDVIC-VRSGELGAVIE---GLLR---VAREH 546
P EG L+CV G V R G L A + LLR V
Sbjct: 2153 PIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPAD 2212
Query: 547 AGTYRCEATNPRGSAAKNVAVTVEY----GPRFEEPSCPSNWTWVEGSGRLFSCEVDGKP 602
+G Y C G +V VT+E GP S+ T EG SC V G+
Sbjct: 2213 SGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQA 2272
Query: 603 QPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAP----GIYVCNATN-RHGSVAKT 657
V GG+ P R R+ A G YVC A+N S+ T
Sbjct: 2273 HAQVTWYKRGGSL--------PARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVT 2324
Query: 658 VV----------VSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGI 707
V + P ++ PS EG + L C G+ V + G
Sbjct: 2325 VTGTQGANLAYPAGSTQPIRIE----PSSSQVAEG-QTLDLNCVVPGQSHAQVTWHKRGG 2379
Query: 708 PWPEQQRV----------SREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPP- 756
P + + S D+G Y C + +V V +E V L +P
Sbjct: 2380 SLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTV 2439
Query: 757 ------GGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGG 810
V G L C AQ++W G+L + S L + + G
Sbjct: 2440 RIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSG 2499
Query: 811 EYECAATNAHGRHARRITVRV 831
EY C + G + V +
Sbjct: 2500 EYVCRVVGSSGTQEASVLVTI 2520
Score = 31.6 bits (70), Expect = 3.6
Identities = 30/112 (26%), Positives = 38/112 (33%), Gaps = 19/112 (16%)
Query: 500 ERITWLEGTEASLSCVAHGVPPP---------------DVICVRSGELGAVIEGLLRVAR 544
E I G + +CVA GVP P V G G +I + V
Sbjct: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI--IRDVKE 471
Query: 545 EHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSC 596
G Y CEA N RG +E P + CP ++E S C
Sbjct: 472 SDQGAYTCEAMNARGMVFGIPDGVLELVP--QRGPCPDGHFYLEHSAACLPC 521
Score = 30.8 bits (68), Expect = 6.1
Identities = 25/87 (28%), Positives = 29/87 (33%), Gaps = 15/87 (17%)
Query: 750 ELAASPPGGVRP---------GGNFTLTCRAEAWPPAQISWRAPPGAL------NIGLSS 794
E PP V P G T TC A P I+WR G + +
Sbjct: 400 EFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG 459
Query: 795 NNSTLSVAGAMGSHGGEYECAATNAHG 821
TL + S G Y C A NA G
Sbjct: 460 GRGTLIIRDVKESDQGAYTCEAMNARG 486
>gi|153082722 intercellular adhesion molecule 2 precursor [Homo
sapiens]
Length = 275
Score = 114 bits (285), Expect = 4e-25
Identities = 73/200 (36%), Positives = 98/200 (49%), Gaps = 1/200 (0%)
Query: 31 QEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDI 90
++ F ++P+ VE GSL +NCST C +PE GGLETSL + +W LV
Sbjct: 24 EKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQW-KHYLVSN 82
Query: 91 REPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPR 150
+T C F C+ + + +Q P +V L P VG++FT+ CRVP P
Sbjct: 83 ISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPL 142
Query: 151 ASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLG 210
SLTL L RG + L +F P + A T A RED NFSC A LDL G
Sbjct: 143 DSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGN 202
Query: 211 LFENSSAPRELRTFSLSPDA 230
+F SAP+ L + D+
Sbjct: 203 IFHKHSAPKMLEIYEPVSDS 222
Score = 36.2 bits (82), Expect = 0.14
Identities = 35/133 (26%), Positives = 52/133 (39%), Gaps = 21/133 (15%)
Query: 300 LVCNVTLGGENRETRENVTIYSFPAP-LLTLSEPSVSEGQMVTVTCAA------------ 346
L C+ T G+ NV++Y P +LTL V+ G+ T+ C
Sbjct: 89 LQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLF 148
Query: 347 ---GAQALVTLEGVPAAVPGQPAQLQLNAT--ENDDRRSFFCDATLDV---DGETLIKNR 398
G + L AA Q A N+T D R+F C A LD+ G K+
Sbjct: 149 LFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHS 208
Query: 399 SAELRVLYAPRLD 411
+ ++ +Y P D
Sbjct: 209 APKMLEIYEPVSD 221
>gi|153082719 intercellular adhesion molecule 2 precursor [Homo
sapiens]
Length = 275
Score = 114 bits (285), Expect = 4e-25
Identities = 73/200 (36%), Positives = 98/200 (49%), Gaps = 1/200 (0%)
Query: 31 QEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDI 90
++ F ++P+ VE GSL +NCST C +PE GGLETSL + +W LV
Sbjct: 24 EKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQW-KHYLVSN 82
Query: 91 REPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPR 150
+T C F C+ + + +Q P +V L P VG++FT+ CRVP P
Sbjct: 83 ISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPL 142
Query: 151 ASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLG 210
SLTL L RG + L +F P + A T A RED NFSC A LDL G
Sbjct: 143 DSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGN 202
Query: 211 LFENSSAPRELRTFSLSPDA 230
+F SAP+ L + D+
Sbjct: 203 IFHKHSAPKMLEIYEPVSDS 222
Score = 36.2 bits (82), Expect = 0.14
Identities = 35/133 (26%), Positives = 52/133 (39%), Gaps = 21/133 (15%)
Query: 300 LVCNVTLGGENRETRENVTIYSFPAP-LLTLSEPSVSEGQMVTVTCAA------------ 346
L C+ T G+ NV++Y P +LTL V+ G+ T+ C
Sbjct: 89 LQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLF 148
Query: 347 ---GAQALVTLEGVPAAVPGQPAQLQLNAT--ENDDRRSFFCDATLDV---DGETLIKNR 398
G + L AA Q A N+T D R+F C A LD+ G K+
Sbjct: 149 LFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHS 208
Query: 399 SAELRVLYAPRLD 411
+ ++ +Y P D
Sbjct: 209 APKMLEIYEPVSD 221
>gi|153082699 intercellular adhesion molecule 2 precursor [Homo
sapiens]
Length = 275
Score = 114 bits (285), Expect = 4e-25
Identities = 73/200 (36%), Positives = 98/200 (49%), Gaps = 1/200 (0%)
Query: 31 QEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDI 90
++ F ++P+ VE GSL +NCST C +PE GGLETSL + +W LV
Sbjct: 24 EKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQW-KHYLVSN 82
Query: 91 REPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPR 150
+T C F C+ + + +Q P +V L P VG++FT+ CRVP P
Sbjct: 83 ISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPL 142
Query: 151 ASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLG 210
SLTL L RG + L +F P + A T A RED NFSC A LDL G
Sbjct: 143 DSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGN 202
Query: 211 LFENSSAPRELRTFSLSPDA 230
+F SAP+ L + D+
Sbjct: 203 IFHKHSAPKMLEIYEPVSDS 222
Score = 36.2 bits (82), Expect = 0.14
Identities = 35/133 (26%), Positives = 52/133 (39%), Gaps = 21/133 (15%)
Query: 300 LVCNVTLGGENRETRENVTIYSFPAP-LLTLSEPSVSEGQMVTVTCAA------------ 346
L C+ T G+ NV++Y P +LTL V+ G+ T+ C
Sbjct: 89 LQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLF 148
Query: 347 ---GAQALVTLEGVPAAVPGQPAQLQLNAT--ENDDRRSFFCDATLDV---DGETLIKNR 398
G + L AA Q A N+T D R+F C A LD+ G K+
Sbjct: 149 LFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHS 208
Query: 399 SAELRVLYAPRLD 411
+ ++ +Y P D
Sbjct: 209 APKMLEIYEPVSD 221
>gi|153082686 intercellular adhesion molecule 2 precursor [Homo
sapiens]
Length = 275
Score = 114 bits (285), Expect = 4e-25
Identities = 73/200 (36%), Positives = 98/200 (49%), Gaps = 1/200 (0%)
Query: 31 QEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDI 90
++ F ++P+ VE GSL +NCST C +PE GGLETSL + +W LV
Sbjct: 24 EKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQW-KHYLVSN 82
Query: 91 REPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPR 150
+T C F C+ + + +Q P +V L P VG++FT+ CRVP P
Sbjct: 83 ISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPL 142
Query: 151 ASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLG 210
SLTL L RG + L +F P + A T A RED NFSC A LDL G
Sbjct: 143 DSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGN 202
Query: 211 LFENSSAPRELRTFSLSPDA 230
+F SAP+ L + D+
Sbjct: 203 IFHKHSAPKMLEIYEPVSDS 222
Score = 36.2 bits (82), Expect = 0.14
Identities = 35/133 (26%), Positives = 52/133 (39%), Gaps = 21/133 (15%)
Query: 300 LVCNVTLGGENRETRENVTIYSFPAP-LLTLSEPSVSEGQMVTVTCAA------------ 346
L C+ T G+ NV++Y P +LTL V+ G+ T+ C
Sbjct: 89 LQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLF 148
Query: 347 ---GAQALVTLEGVPAAVPGQPAQLQLNAT--ENDDRRSFFCDATLDV---DGETLIKNR 398
G + L AA Q A N+T D R+F C A LD+ G K+
Sbjct: 149 LFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHS 208
Query: 399 SAELRVLYAPRLD 411
+ ++ +Y P D
Sbjct: 209 APKMLEIYEPVSD 221
>gi|153082696 intercellular adhesion molecule 2 precursor [Homo
sapiens]
Length = 275
Score = 114 bits (285), Expect = 4e-25
Identities = 73/200 (36%), Positives = 98/200 (49%), Gaps = 1/200 (0%)
Query: 31 QEPFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDI 90
++ F ++P+ VE GSL +NCST C +PE GGLETSL + +W LV
Sbjct: 24 EKVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQW-KHYLVSN 82
Query: 91 REPETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPR 150
+T C F C+ + + +Q P +V L P VG++FT+ CRVP P
Sbjct: 83 ISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPL 142
Query: 151 ASLTLTLLRGAQELIRRSFAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPHGLG 210
SLTL L RG + L +F P + A T A RED NFSC A LDL G
Sbjct: 143 DSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGN 202
Query: 211 LFENSSAPRELRTFSLSPDA 230
+F SAP+ L + D+
Sbjct: 203 IFHKHSAPKMLEIYEPVSDS 222
Score = 36.2 bits (82), Expect = 0.14
Identities = 35/133 (26%), Positives = 52/133 (39%), Gaps = 21/133 (15%)
Query: 300 LVCNVTLGGENRETRENVTIYSFPAP-LLTLSEPSVSEGQMVTVTCAA------------ 346
L C+ T G+ NV++Y P +LTL V+ G+ T+ C
Sbjct: 89 LQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLF 148
Query: 347 ---GAQALVTLEGVPAAVPGQPAQLQLNAT--ENDDRRSFFCDATLDV---DGETLIKNR 398
G + L AA Q A N+T D R+F C A LD+ G K+
Sbjct: 149 LFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHS 208
Query: 399 SAELRVLYAPRLD 411
+ ++ +Y P D
Sbjct: 209 APKMLEIYEPVSD 221
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 101 bits (252), Expect = 3e-21
Identities = 129/492 (26%), Positives = 185/492 (37%), Gaps = 82/492 (16%)
Query: 418 SWTWPEGPEQTLRCEARGNPEPSVHCARSDGG------------AVLALGLLG--PVTRA 463
S+T P + L CEA GNP P++H R G VL G L V
Sbjct: 1657 SFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQ 1716
Query: 464 LSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPD 523
G Y C A+N G VTL+V P + IT G+ L C A G P P
Sbjct: 1717 DRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAEGRPSPT 1776
Query: 524 VICV------------RSGELGAVIEGLL---RVAREHAGTYRCEATNPRGSAAKNVAVT 568
V + S + ++G L ++ G Y+C A+NP G + V +
Sbjct: 1777 VTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDSLLVKIQ 1836
Query: 569 VEYGPR--FEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPD 626
V P E+ TW G C G PQPSV V S G + PL +
Sbjct: 1837 VIAAPPVILEQRRQVIVGTW--GESLKLPCTAKGTPQPSVYWVLSDGTE---VKPLQFTN 1891
Query: 627 PS----PRAPRIPRVLAP---GIYVCNATNRHGSVAKTVVVSAE---SPPEMDESTCPSH 676
R LA G Y C AT+ GS + V+++ E + P ++ ++
Sbjct: 1892 SKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERVTSPRIEAAS--QK 1949
Query: 677 QTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQR------------------VSRE 718
+T + + L C+A G P P + +QQ V+ +
Sbjct: 1950 RTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIHVYPNGSLFIGSVTEK 2009
Query: 719 DAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQ 778
D+G Y CVA N G D + V + +P + V G +F + C+A P +
Sbjct: 2010 DSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPE 2069
Query: 779 ISWRAPPGA-LNIGLSS-------------NNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
ISW P G +N + + NN TL + G+Y C A N G+
Sbjct: 2070 ISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDE 2129
Query: 825 RRI--TVRVAGP 834
++ TV A P
Sbjct: 2130 MKVHLTVITAAP 2141
Score = 70.9 bits (172), Expect = 5e-12
Identities = 132/591 (22%), Positives = 214/591 (36%), Gaps = 115/591 (19%)
Query: 323 PAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFF 382
P+P +T ++ +V+ + QA+VT++G L L+ DR +
Sbjct: 1773 PSPTVTWI---LANQTVVSESSQGSRQAVVTVDGT----------LVLHNLSIYDRGFYK 1819
Query: 383 CDATLDVDGETLIKNRSAELRVLYAPR--LDDSDCPRSWTWPEGPEQTLRCEARGNPEPS 440
C A+ ++L+ +++V+ AP L+ TW G L C A+G P+PS
Sbjct: 1820 CVASNPGGQDSLL----VKIQVIAAPPVILEQRRQVIVGTW--GESLKLPCTAKGTPQPS 1873
Query: 441 VHCARSDGGAVLALGLLGPVTRALS--------------GTYRCKAANDQGEAVKDVTLT 486
V+ SDG V L S GTY C A + G + V LT
Sbjct: 1874 VYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLT 1933
Query: 487 VE---YAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDV--------ICVRSGELGAV 535
+E +P +++ +R G + L+C A G P P + + + +G+
Sbjct: 1934 MEERVTSPRIEAAS-QKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSW 1992
Query: 536 I----EGLL---RVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVE 588
I G L V + +G Y C A N G + V++ P + +
Sbjct: 1993 IHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLH 2052
Query: 589 GSGRLFSCEVDGKPQPSVKCVGSGGATEGVLL--PLAPPDPSPRAPRIP----------- 635
G C+ G P P + S +G ++ + D R R
Sbjct: 2053 GKDFQVDCKASGSPVPEI----SWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNK 2108
Query: 636 -RVLAPGIYVCNATNRHG----SVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALAC 690
V G Y C A N G V TV+ +A P + +S + + ++ + + L C
Sbjct: 2109 VGVAEEGDYTCYAQNTLGKDEMKVHLTVITAA---PRIRQSNKTNKR--IKAGDTAVLDC 2163
Query: 691 AARGRPSPGV---RCSREGIPWPEQQ------------RVSREDAGTYHCVATNAHGTDS 735
G P P + S + I + + +V D+G Y CVA N G D+
Sbjct: 2164 EVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDT 2223
Query: 736 RTVTVGVEYRP-----VVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGALNI 790
+ + V +P + VR CRAE P ++ W P NI
Sbjct: 2224 KMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH-FDCRAEGTPSPEVMWIMPD---NI 2279
Query: 791 GLSS----------NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRV 831
L++ N TL + S ++ C A N G + + V
Sbjct: 2280 FLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV 2330
Score = 67.0 bits (162), Expect = 8e-11
Identities = 113/482 (23%), Positives = 165/482 (34%), Gaps = 85/482 (17%)
Query: 424 GPEQTLRCEARGNPEPSVHCARSDGGAV---LALGLLGPVTR-----------------A 463
G + + C+A G+P P + + DG + + G TR A
Sbjct: 2053 GKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVA 2112
Query: 464 LSGTYRCKAANDQGEAVKDVTLTV-EYAPAL-DSVGCPERITWLEGTEASLSCVAHGVPP 521
G Y C A N G+ V LTV AP + S +RI G A L C G P
Sbjct: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIK--AGDTAVLDCEVTGDPK 2170
Query: 522 P---------DVICVRSGELGAVIEGLLRVAREH---AGTYRCEATNPRGSAAKNVAVTV 569
P D+I G L + + +G Y C A NP G K + V
Sbjct: 2171 PKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGDDTKMYKLDV 2230
Query: 570 EYGPRFEEPSCPSNW----TWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPP 625
P + T V S + F C +G P P V + + L P
Sbjct: 2231 VSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDN------IFLTAP 2284
Query: 626 DPSPRAP---------RIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSH 676
R R R+ ++C A N G V + P +
Sbjct: 2285 YYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRNPFN 2344
Query: 677 QTWL-EGAEASALACAARGRPSP--------GVRCSREGIPWPEQ-----------QRVS 716
+ + + +++AL C+ G P P G R S P Q + +
Sbjct: 2345 EKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNG--PQSYQYLIASNGSFIISKTT 2402
Query: 717 REDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPP 776
REDAG Y C A N G + V + + +PV+ A G+ G + +L C ++ P
Sbjct: 2403 REDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGI-SGESLSLHCVSDGIPK 2461
Query: 777 AQISWRAPPGAL-------NIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITV 829
I W P G + + +N TL + A G Y C A N+ G + V
Sbjct: 2462 PNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPV 2521
Query: 830 RV 831
+
Sbjct: 2522 MI 2523
Score = 65.1 bits (157), Expect = 3e-10
Identities = 90/356 (25%), Positives = 124/356 (34%), Gaps = 54/356 (15%)
Query: 431 CEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSGT-------------YRCKAANDQG 477
C A G P P V D + A +T +GT + C A N+ G
Sbjct: 2261 CRAEGTPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGG 2320
Query: 478 EAVKDVTLTVEYAPALDSVGCP--ERITWLEGTEASLSCVAHGVPPPDVICV-------- 527
E+V V L V + P E+I G +L+C G PPP++I +
Sbjct: 2321 ESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFS 2380
Query: 528 ---RSGELGAVIEG---LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCP 581
+S + G + + RE AG YRC A N G K V + + P P
Sbjct: 2381 NGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVI-LTYAP 2439
Query: 582 SNWTWVEGSGRLFSCEVDGKPQPSVK-CVGSGGATEGVLL--PLAPPDPSPRAPRIPRVL 638
+ G C DG P+P++K + SG + + D +
Sbjct: 2440 GTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAY 2499
Query: 639 APGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSP 698
G Y+C A N G TV V + P + P GA A L C A G P P
Sbjct: 2500 DRGNYICKAQNSVGHTLITVPVMIVAYPPRITNRPPRSIVTRTGA-AFQLHCVALGVPKP 2558
Query: 699 GV-----------RCSREGIPWPEQ---------QRVSREDAGTYHCVATNAHGTD 734
+ S+E EQ Q D+G Y C A N G+D
Sbjct: 2559 EITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSD 2614
Score = 63.5 bits (153), Expect = 8e-10
Identities = 108/462 (23%), Positives = 161/462 (34%), Gaps = 69/462 (14%)
Query: 424 GPEQTLRCEARGNPEPSVHCARSDGGAVL---------ALGLL--GPVTRALSGTYRCKA 472
G L CE G+P+P + + A G L V SG Y C A
Sbjct: 2156 GDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVA 2215
Query: 473 ANDQGEAVKDVTLTVEYAPALDSVGCPERI----TWLEGTEASLSCVAHGVPPPDVICVR 528
N G+ K L V P L + R T + ++ C A G P P+V+ +
Sbjct: 2216 RNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIM 2275
Query: 529 SGEL-------GAVI----EGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTVEYGPR 574
+ G+ I G L + + + C A N G + V + V R
Sbjct: 2276 PDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLR 2335
Query: 575 FEEPSCPSNWTWVE--GSGRLFSCEVDGKPQPSVKCVGSGGATEG----VLLPLAPPDPS 628
P N V G +C VDG P P + + G L + S
Sbjct: 2336 RPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGS 2395
Query: 629 PRAPRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASAL 688
+ R A G Y C A N+ G + K V++ P + + P + G E+ +L
Sbjct: 2396 FIISKTTREDA-GKYRCAARNKVGYIEKLVILEIGQKPVI-LTYAPGTVKGISG-ESLSL 2452
Query: 689 ACAARGRPSPGVRCSREGIPWPEQQRVSRE-----------------DAGTYHCVATNAH 731
C + G P P ++ + ++ +++ + D G Y C A N+
Sbjct: 2453 HCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSV 2512
Query: 732 GTDSRTVTVGVEYRPVVAELAASPPGGV--RPGGNFTLTCRAEAWPPAQISWRAPPGALN 789
G TV V + P + PP + R G F L C A P +I+W P +L
Sbjct: 2513 GHTLITVPVMIVAYP--PRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLL 2570
Query: 790 IGLSSNNS----------TLSVAGAMGSHGGEYECAATNAHG 821
S + TL + S G Y+C A N G
Sbjct: 2571 STASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
Score = 60.8 bits (146), Expect = 5e-09
Identities = 81/307 (26%), Positives = 116/307 (37%), Gaps = 57/307 (18%)
Query: 575 FEEPSC----PSNWTWVEGSGRLFSCEVDGKPQPSVKC--VGSGGATEGVLLPLAPPDPS 628
FE+P +++T S CE G P P++ V SG L L+ +
Sbjct: 1645 FEKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSG-------LDLSKRKQN 1697
Query: 629 PRAPRIPR---------VLAPGIYVCNATNRHGSVAKTVVVSAES-PPEMDESTCPSHQT 678
R +P + G Y+C+A+N G+ V +S S PP + E + +
Sbjct: 1698 SRVQVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERR--TKEI 1755
Query: 679 WLEGAEASALACAARGRPSPGV--------------RCSREGIPWPE----QQRVSREDA 720
+ L C A GRPSP V + SR+ + + +S D
Sbjct: 1756 TVHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDR 1815
Query: 721 GTYHCVATNAHGTDSRTVTVGV-EYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQI 779
G Y CVA+N G DS V + V PV+ E G G + L C A+ P +
Sbjct: 1816 GFYKCVASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTW-GESLKLPCTAKGTPQPSV 1874
Query: 780 SWRAPPGALNIGLSSNNS--------TLSVAGAMGSHGGEYECAATNAHGRHARRITV-- 829
W G L NS TL + S G YEC AT++ G R + +
Sbjct: 1875 YWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTM 1934
Query: 830 --RVAGP 834
RV P
Sbjct: 1935 EERVTSP 1941
Score = 52.4 bits (124), Expect = 2e-06
Identities = 67/268 (25%), Positives = 96/268 (35%), Gaps = 44/268 (16%)
Query: 424 GPEQTLRCEARGNPEPSVHCARSDGG-------------AVLALGLLGPVTRALSGTYRC 470
G L C GNP P + +G A ++ TR +G YRC
Sbjct: 2352 GKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRC 2411
Query: 471 KAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDV------ 524
A N G K V L + P + + P + + G SL CV+ G+P P++
Sbjct: 2412 AARNKVGYIEKLVILEIGQKPVILTY-APGTVKGISGESLSLHCVSDGIPKPNIKWTMPS 2470
Query: 525 --ICVRSGELGAVI---EGLLRVAREHA---GTYRCEATNPRGSAAKNVAV-TVEYGPRF 575
+ R G I G L + A G Y C+A N G V V V Y PR
Sbjct: 2471 GYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMIVAYPPRI 2530
Query: 576 EEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRI- 634
P + G+ C G P+P + + + LL A + + + ++
Sbjct: 2531 TNRP-PRSIVTRTGAAFQLHCVALGVPKPEI----TWEMPDHSLLSTASKERTHGSEQLH 2585
Query: 635 ---------PRVLAPGIYVCNATNRHGS 653
P+ GIY C A N GS
Sbjct: 2586 LQGTLVIQNPQTSDSGIYKCTAKNPLGS 2613
Score = 44.3 bits (103), Expect = 5e-04
Identities = 34/116 (29%), Positives = 41/116 (35%), Gaps = 5/116 (4%)
Query: 711 EQQRVSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCR 770
E Q D G YHC+++N D T + V V A V G L C
Sbjct: 537 ELQMADSFDTGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCH 596
Query: 771 AEAWPPAQISWRAPPGALNIGLSS-----NNSTLSVAGAMGSHGGEYECAATNAHG 821
+ P A ISW P + S NN TL + G Y C A N G
Sbjct: 597 STGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 31.6 bits (70), Expect = 3.6
Identities = 37/160 (23%), Positives = 58/160 (36%), Gaps = 31/160 (19%)
Query: 429 LRCEARGNPEPSVHCARSDGGAVLA----------LGLLGPVTRALS-----GTYRCKAA 473
L C +G+P P V +DG V A + G + ++ G Y C ++
Sbjct: 495 LNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVYHCISS 554
Query: 474 N--DQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVP--------PPD 523
N D +T+ A G + G L C + G+P P +
Sbjct: 555 NYDDADILTYRITVVEPLVEAYQENGIHHTV--FIGETLDLPCHSTGIPDASISWVIPGN 612
Query: 524 VICVRSGELGAVIEG----LLRVAREHAGTYRCEATNPRG 559
+ +S V+ +L+V + G YRC A NP G
Sbjct: 613 NVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
>gi|157168355 CD22 molecule [Homo sapiens]
Length = 847
Score = 98.2 bits (243), Expect = 3e-20
Identities = 156/620 (25%), Positives = 238/620 (38%), Gaps = 79/620 (12%)
Query: 250 TLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEGARQLVCNVTLGGE 309
T DG P+ + RV LGD+N + +++ + QL + E
Sbjct: 80 TKDGKVPSEQKRVQF-LGDKNKNCTLSIH------------PVHLNDSGQLGLRMESKTE 126
Query: 310 NRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAG-------AQALVTLEGVP---A 359
R ++ + P P P + E Q VT+TC Q LEGVP A
Sbjct: 127 KWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQA 186
Query: 360 AVPGQPAQLQLNATENDDRRS---------FFCDATLDVDGETLIKNRSAELRVLYAPRL 410
AV ++ T ++ + S C D DG+ L N + +L V + P+L
Sbjct: 187 AVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQ-DADGKFL-SNDTVQLNVKHTPKL 244
Query: 411 DDSDCPRSWTWPEGPEQTLRCE-ARGNPEPSVHCARSDGGAVLALGL----LGPVTRALS 465
+ P EG T+ CE + NPE + DG ++ L VT+ S
Sbjct: 245 EIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQS 304
Query: 466 GTYRCKAANDQGEA-VKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVP-PPD 523
G Y C+ +ND G ++V L V+YAP +V +EG++ C++ P P +
Sbjct: 305 GKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPA-VEGSQVEFLCMSLANPLPTN 363
Query: 524 VICVRSG-ELGAVIEGLLRVAR---EHAGTYRCEATNPRGSAAK--NVAVTVEYGPRFEE 577
+G E+ E + + + HAGTY C A N G+ + + V+Y P+
Sbjct: 364 YTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVT 423
Query: 578 PSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCV--GSGGATEGVLLPLAPPDPSPRAPRIP 635
+ EG SC + PSV GA E +PS +I
Sbjct: 424 TVIQNPMPIREGDTVTLSCNYNSS-NPSVTRYEWKPHGAWE---------EPSLGVLKIQ 473
Query: 636 RVLAPGIYV-CNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARG 694
V + C A N S A V ++ + P + + + +L C
Sbjct: 474 NVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSS 533
Query: 695 RPSPGVRCSRE---GIPWPEQQ----RVSREDAGTYHCVATNAHG-TDSRTVTVGVEYRP 746
V+ E + E Q +S EDAG+Y C N+ G T S+ T+ V Y P
Sbjct: 534 SHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAP 593
Query: 747 VVAELAASPPGGVRPGGNFTLTCRAEAWPPAQ----ISWRAPPGALNIGLSSNNSTLSVA 802
++ SP V G + TLTC ++A PP W N L ++ L +
Sbjct: 594 RRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWN------NQSLPYHSQKLRLE 647
Query: 803 GAMGSHGGEYECAATNAHGR 822
H G Y C TN+ G+
Sbjct: 648 PVKVQHSGAYWCQGTNSVGK 667
>gi|4507875 vascular cell adhesion molecule 1 isoform a precursor
[Homo sapiens]
Length = 739
Score = 95.9 bits (237), Expect = 2e-19
Identities = 163/723 (22%), Positives = 260/723 (35%), Gaps = 103/723 (14%)
Query: 238 LLEVGSERPVSCTLDGL-FPASEARVYLALGDQNLSPDVTLEGDAFVATATATASAEQEG 296
L ++G ++C+ G P R + D L+ VT EG T+T T + G
Sbjct: 36 LAQIGDSVSLTCSTTGCESPFFSWRTQI---DSPLNGKVTNEG----TTSTLTMNPVSFG 88
Query: 297 -ARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEPSVSEGQMVTVTCAA-------- 346
+C T E V IYSFP P + LS P + G+ +TV C+
Sbjct: 89 NEHSYLCTATCESRKLEKGIQVEIYSFPKDPEIHLSGP-LEAGKPITVKCSVADVYPFDR 147
Query: 347 -------GAQALVTLEGVPAA----VPGQPAQLQLNATENDDRRSFFCDATL---DVDGE 392
G + + E + A + + ++ D + C A L ++D
Sbjct: 148 LEIDLLKGDHLMKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHIDEMDSV 207
Query: 393 TLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARS-DGGAV 451
++ EL+V +P+ S EG T+ C + G P P + ++ D G +
Sbjct: 208 PTVRQAVKELQVYISPKNTVISVNPSTKLQEGGSVTMTCSSEGLPAPEIFWSKKLDNGNL 267
Query: 452 LALGLLGPVTRAL-------SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITW 504
L G T L SG Y C+ N G+ K+V L V+ P + RI
Sbjct: 268 QHLS--GNATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIAA 325
Query: 505 LEGTEASLSCVAHGVPPPDVIC-----------VRSGELGAVIEGLLRVAREHAGTYRCE 553
G L+C G P VRS + + L V+ E+ +Y C
Sbjct: 326 QIGDSVMLTCSVMGCESPSFSWRTQIDSPLSGKVRSEGTNSTLT-LSPVSFENEHSYLCT 384
Query: 554 ATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGK---PQPSVKCVG 610
T K + V + PR +P + V GS SC+V + ++ +
Sbjct: 385 VTCGHKKLEKGIQVELYSFPR--DPEIEMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLK 442
Query: 611 SGGATEGVLLPLAPPDPSPRAPRIPRVLAPGI------YVCNAT---------NRHGSVA 655
E + S + P I VC A +
Sbjct: 443 GETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQST 502
Query: 656 KTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQRV 715
+T+ V+ D + S + LE + + C ++G P+P + SR+ +P E Q +
Sbjct: 503 QTLYVNVAP---RDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQ-LPNGELQPL 558
Query: 716 SR-----------EDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGN 764
S ED+G Y C N G + V + ++ P +L A P V+ G
Sbjct: 559 SENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPSESVKEGDT 618
Query: 765 FTLTCRAEAWPPAQISWRAPPGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
++C P I + + L S + ++ A G YEC + N G
Sbjct: 619 VIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIRKAQLKDAGVYECESKNKVGSQL 678
Query: 825 RRITVRVAG---------PWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEA 875
R +T+ V G P L V ++L+ G+ Y A KG Y++ EA
Sbjct: 679 RSLTLDVQGRENNKDYFSPELLVLY----FASSLIIPAIGMIIYFARKANMKGSYSLVEA 734
Query: 876 ESS 878
+ S
Sbjct: 735 QKS 737
Score = 75.1 bits (183), Expect = 3e-13
Identities = 94/390 (24%), Positives = 152/390 (38%), Gaps = 59/390 (15%)
Query: 223 TFSLSPDAPRLAAPRLLEVGSERPVSCTLDGL-FPASEARVYLALGDQNLSPDVTLEGDA 281
T +SP PR+AA ++G ++C++ G P+ R + D LS V EG
Sbjct: 314 TVEISP-GPRIAA----QIGDSVMLTCSVMGCESPSFSWRTQI---DSPLSGKVRSEGTN 365
Query: 282 FVATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPA-PLLTLSEPSVSEGQMV 340
T + + E +C VT G + E V +YSFP P + +S V+ G V
Sbjct: 366 STLTLSPVSF---ENEHSYLCTVTCGHKKLEKGIQVELYSFPRDPEIEMSGGLVN-GSSV 421
Query: 341 TVTCAA---------------GAQALVTLEGVP----AAVPGQPAQLQLNATENDDRRSF 381
TV+C G L +E + ++ + ++ T D ++
Sbjct: 422 TVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTFIPTIEDTGKAL 481
Query: 382 FCDATLDVDGETLIKNRSAELRVLY---APRLDDSDCPRSWTWPEGPEQTLRCEARGNPE 438
C A L +D + + LY APR S EG + C ++G P
Sbjct: 482 VCQAKLHIDDMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPA 541
Query: 439 PSVHCARSDGGAVLALGLLGPVTRAL-----------SGTYRCKAANDQGEAVKDVTLTV 487
P + +R L G L P++ SG Y C+ N G + K+V L +
Sbjct: 542 PKILWSRQ-----LPNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELII 596
Query: 488 EYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGAV----IEGLLRVA 543
+ P + + EG +SC VP +I + E G I+G +
Sbjct: 597 QVTPKDIKLTAFPSESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSIDGAYTIR 656
Query: 544 R---EHAGTYRCEATNPRGSAAKNVAVTVE 570
+ + AG Y CE+ N GS +++ + V+
Sbjct: 657 KAQLKDAGVYECESKNKVGSQLRSLTLDVQ 686
Score = 61.2 bits (147), Expect = 4e-09
Identities = 144/680 (21%), Positives = 246/680 (36%), Gaps = 97/680 (14%)
Query: 48 GGSLWLNCSTN-CPRPE---RGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRC 103
G S+ L CST C P R +++ L T G E +C C
Sbjct: 40 GDSVSLTCSTTGCESPFFSWRTQIDSPLNGKVTNEGTTSTLTMNPVSFGNEHSYLCTATC 99
Query: 104 ARRTLQARGLIRTFQRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQE 163
R L+ + + P E+ P + G+ T+ C V P L + LL+G
Sbjct: 100 ESRKLEKGIQVEIYSFPKDPEIHLSGPLE-AGKPITVKCSVADVYPFDRLEIDLLKGDHL 158
Query: 164 LIRRSFAGEPPR--ARGAVLTATVLARREDHGANFSCRAELDLRPHGLGLFENSSAP--- 218
+ + F + R L T ED G CRA+L + E S P
Sbjct: 159 MKSQEFLEDADRKSLETKSLEVTFTPVIEDIGKVLVCRAKLHID-------EMDSVPTVR 211
Query: 219 ---RELRTFSLSPDAPRLAA--PRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSP 273
+EL+ + +SP ++ L+ G ++C+ +GL PA E L + NL
Sbjct: 212 QAVKELQVY-ISPKNTVISVNPSTKLQEGGSVTMTCSSEGL-PAPEIFWSKKLDNGNLQ- 268
Query: 274 DVTLEGDAFVATATATASAEQEGARQLVCNVTLGGENRETRENV------TIYSFPAPLL 327
L G+ AT T A ++ + V L G+NR+ E + T+ P P +
Sbjct: 269 --HLSGN---ATLTLIAMRMEDSGIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRI 323
Query: 328 TLSEPSVSEGQMVTVTCAA----------GAQALVTLEGVPAAVPGQPAQLQLNATENDD 377
+ G V +TC+ Q L G G + L L+ ++
Sbjct: 324 -----AAQIGDSVMLTCSVMGCESPSFSWRTQIDSPLSG-KVRSEGTNSTLTLSPVSFEN 377
Query: 378 RRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARG-N 436
S+ C T G ++ + ++ + PR D + S G T+ C+
Sbjct: 378 EHSYLCTVTC---GHKKLE-KGIQVELYSFPR--DPEIEMSGGLVNGSSVTVSCKVPSVY 431
Query: 437 PEPSVHCARSDGGAVLA-------LGLLGPVTRALSGTYRCKAANDQGEAV--------- 480
P + G +L + ++L T+ D G+A+
Sbjct: 432 PLDRLEIELLKGETILENIEFLEDTDMKSLENKSLEMTF-IPTIEDTGKALVCQAKLHID 490
Query: 481 ----------KDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVR-- 528
TL V AP +V EG+ +++C++ G P P ++ R
Sbjct: 491 DMEFEPKQRQSTQTLYVNVAPRDTTVLVSPSSILEEGSSVNMTCLSQGFPAPKILWSRQL 550
Query: 529 -SGELGAVIEG----LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSN 583
+GEL + E L+ E +G Y CE N G + K V + ++ P+ + + +
Sbjct: 551 PNGELQPLSENATLTLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS 610
Query: 584 WTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIY 643
+ EG + SC P+ + + VL + R ++ G+Y
Sbjct: 611 ESVKEGDTVIISCTCGNVPETWIILKKKAETGDTVLKSI----DGAYTIRKAQLKDAGVY 666
Query: 644 VCNATNRHGSVAKTVVVSAE 663
C + N+ GS +++ + +
Sbjct: 667 ECESKNKVGSQLRSLTLDVQ 686
Score = 52.8 bits (125), Expect = 1e-06
Identities = 88/369 (23%), Positives = 144/369 (39%), Gaps = 64/369 (17%)
Query: 14 GLWAALGLGLFGLSA------VSQEPFWADLQP--RVAFVERGGSLWLNCST-NCPRPE- 63
G++ G+ L G + V ++PF ++ P R+A + G S+ L CS C P
Sbjct: 287 GIYVCEGVNLIGKNRKEVELIVQEKPFTVEISPGPRIA-AQIGDSVMLTCSVMGCESPSF 345
Query: 64 ------RGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTF 117
L +R GT L E E +C C + L+ + +
Sbjct: 346 SWRTQIDSPLSGKVRSEGTNSTLTLSPVSF----ENEHSYLCTVTCGHKKLEKGIQVELY 401
Query: 118 QRPDRVELMPLPPWQPVGENFTLSCRVPGAGPRASLTLTLLRGAQELIRRSFAGEP--PR 175
P E+ + G + T+SC+VP P L + LL+G L F +
Sbjct: 402 SFPRDPEI-EMSGGLVNGSSVTVSCKVPSVYPLDRLEIELLKGETILENIEFLEDTDMKS 460
Query: 176 ARGAVLTATVLARREDHGANFSCRAELDL---------RPHGLGLFENSSAPRELRTFSL 226
L T + ED G C+A+L + R L+ N APR+ T +
Sbjct: 461 LENKSLEMTFIPTIEDTGKALVCQAKLHIDDMEFEPKQRQSTQTLYVN-VAPRD-TTVLV 518
Query: 227 SPDAPRLAAPRLLEVGSERPVSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFVATA 286
SP + +LE GS ++C G FPA + L + L P+ L+ + AT
Sbjct: 519 SPSS-------ILEEGSSVNMTCLSQG-FPAPK-----ILWSRQL-PNGELQPLSENATL 564
Query: 287 TATASAEQEGARQLVCNVTLGGENRE--------TRENVTIYSFPAPLLTLSEPSVSEGQ 338
T ++ ++ L + G +R+ T +++ + +FP+ SV EG
Sbjct: 565 TLISTKMEDSGVYLCEGINQAGRSRKEVELIIQVTPKDIKLTAFPS-------ESVKEGD 617
Query: 339 MVTVTCAAG 347
V ++C G
Sbjct: 618 TVIISCTCG 626
>gi|237858682 neurofascin isoform 6 precursor [Homo sapiens]
Length = 613
Score = 91.7 bits (226), Expect = 3e-18
Identities = 97/377 (25%), Positives = 148/377 (39%), Gaps = 63/377 (16%)
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG----ELGAVIEG------LLRVAREHAGTYRCEA 554
L G + L C+A GVP PD+ + G A E + V+ E +G Y C A
Sbjct: 253 LRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLA 312
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
+N GS ++V V+ P + + P N G C +G P+P+V+ +
Sbjct: 313 SNKMGSIRHTISVRVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWM----- 365
Query: 615 TEGVLLPLAPPDPSPRAP------RIPRVLAPGIYVCNATNRHGSVAKTVVVSA-ESPPE 667
G L APP+P+ R ++ + +Y CN +N HG + VS + PP
Sbjct: 366 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 425
Query: 668 MDESTCPSHQ-TWLEGAEASALACAARGRPSPGVRCSREGIPWP--------------EQ 712
M P +Q + + L C G P P +R + G E
Sbjct: 426 M---LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 482
Query: 713 QRVSREDAGTYHCVATNAHGTDSRTVTVGVE-----YRPVVAELAASPPGGVRPGGNFTL 767
+ + +ED G Y CVATN G V + V+ YR ++A R G L
Sbjct: 483 KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA-------RRGTTVQL 535
Query: 768 TCRAEAWPPAQ--ISWRAPPGALNIG--LSSNNSTLSVAGAMGSHGGEYECAATNAHGRH 823
CR + P + +SW L IG + + +L++ G G Y C A+ +
Sbjct: 536 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 595
Query: 824 ARRITVRVAG-----PW 835
+ + V G PW
Sbjct: 596 LAKAYLTVLGNCPCSPW 612
Score = 62.8 bits (151), Expect = 1e-09
Identities = 110/470 (23%), Positives = 154/470 (32%), Gaps = 73/470 (15%)
Query: 429 LRCEARGNPEPSVHCARSD----------------GGAVLALGLLGPVTRALSGTYRCKA 472
+ CEA+GNP PS H R+ G ++ G G Y+C A
Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
Query: 473 ANDQGEAVKD-VTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGE 531
N G A+ + + L V +P + + EG +L C P VI S
Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 173
Query: 532 LGAVIEGLLRVAREHAG--------------TYRCEA----------TNPRGSAAKNVAV 567
+ + + RV++ H G Y C A NP
Sbjct: 174 MEPITQD-KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 232
Query: 568 TVEYGPRFEEP-SCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPD 626
E P F P S+ + G L C G P P + GG A +
Sbjct: 233 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS---DKAKFE 289
Query: 627 PSPRAPRIPRVLA--PGIYVCNATNRHGSVAKTVVVSAESPPE-MDESTCPSHQTWLEGA 683
+A RI V G Y C A+N+ GS+ T+ V ++ P +DE P + G
Sbjct: 290 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE---PKNLILAPG- 345
Query: 684 EASALACAARGRPSPGVRCSREGIPWPE-QQRVSREDAG--------------TYHCVAT 728
E L C A G P P V+ G P +RE AG Y C +
Sbjct: 346 EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 405
Query: 729 NAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGAL 788
N HG V V P + V L C P + W
Sbjct: 406 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGS 465
Query: 789 NIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
N+ + N +L + G Y C ATN G+ ++ + V P
Sbjct: 466 NLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 515
Score = 42.4 bits (98), Expect = 0.002
Identities = 60/266 (22%), Positives = 100/266 (37%), Gaps = 40/266 (15%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L++ +D +FC A+ + + +RV AP D P++ G +
Sbjct: 295 LRITNVSEEDSGEYFCLASNKMGSI----RHTISVRVKAAPYWLDE--PKNLILAPGEDG 348
Query: 428 TLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSG--------------TYRCKAA 473
L C A GNP+P+V + G L P R ++G Y+C +
Sbjct: 349 RLVCRANGNPKPTVQWMVN--GEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTS 405
Query: 474 NDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELG 533
N+ G + + ++V P + I + L C G P P + ++G+ G
Sbjct: 406 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-G 464
Query: 534 AVIEG------------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCP 581
+ ++G + + +E G Y C ATN G A V + V+ R P
Sbjct: 465 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR--MP 522
Query: 582 SNWTWVEGSGRLFSCEVDGKPQPSVK 607
+ G+ C V K PS+K
Sbjct: 523 EDQVARRGTTVQLECRV--KHDPSLK 546
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/80 (30%), Positives = 31/80 (38%), Gaps = 5/80 (6%)
Query: 762 GGNFTLTCRAEAWPPAQISWRAPPGAL---NIGLSSNNSTLSVAGAMGSHGGEYECAATN 818
G + L C A P I+W G L + N L + GEY C A+N
Sbjct: 255 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 314
Query: 819 AHG--RHARRITVRVAGPWL 836
G RH + V+ A WL
Sbjct: 315 KMGSIRHTISVRVKAAPYWL 334
Score = 30.4 bits (67), Expect = 7.9
Identities = 24/90 (26%), Positives = 35/90 (38%), Gaps = 11/90 (12%)
Query: 759 VRPGGNFTLTCRAEAWPPAQISWRAPPGALNIG------LSSNNSTLSV----AGAMGSH 808
V P N + C A+ P W NI + + TL + G +
Sbjct: 47 VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEY 106
Query: 809 GGEYECAATNAHGRH-ARRITVRVAGPWLW 837
GEY+C A N G + RI ++V+ LW
Sbjct: 107 EGEYQCFARNKFGTALSNRIRLQVSKSPLW 136
>gi|237858680 neurofascin isoform 5 precursor [Homo sapiens]
Length = 619
Score = 91.7 bits (226), Expect = 3e-18
Identities = 97/377 (25%), Positives = 148/377 (39%), Gaps = 63/377 (16%)
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG----ELGAVIEG------LLRVAREHAGTYRCEA 554
L G + L C+A GVP PD+ + G A E + V+ E +G Y C A
Sbjct: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLA 318
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
+N GS ++V V+ P + + P N G C +G P+P+V+ +
Sbjct: 319 SNKMGSIRHTISVRVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWM----- 371
Query: 615 TEGVLLPLAPPDPSPRAP------RIPRVLAPGIYVCNATNRHGSVAKTVVVSA-ESPPE 667
G L APP+P+ R ++ + +Y CN +N HG + VS + PP
Sbjct: 372 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
Query: 668 MDESTCPSHQ-TWLEGAEASALACAARGRPSPGVRCSREGIPWP--------------EQ 712
M P +Q + + L C G P P +R + G E
Sbjct: 432 M---LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 488
Query: 713 QRVSREDAGTYHCVATNAHGTDSRTVTVGVE-----YRPVVAELAASPPGGVRPGGNFTL 767
+ + +ED G Y CVATN G V + V+ YR ++A R G L
Sbjct: 489 KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA-------RRGTTVQL 541
Query: 768 TCRAEAWPPAQ--ISWRAPPGALNIG--LSSNNSTLSVAGAMGSHGGEYECAATNAHGRH 823
CR + P + +SW L IG + + +L++ G G Y C A+ +
Sbjct: 542 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 601
Query: 824 ARRITVRVAG-----PW 835
+ + V G PW
Sbjct: 602 LAKAYLTVLGNCPCSPW 618
Score = 62.8 bits (151), Expect = 1e-09
Identities = 110/470 (23%), Positives = 154/470 (32%), Gaps = 73/470 (15%)
Query: 429 LRCEARGNPEPSVHCARSD----------------GGAVLALGLLGPVTRALSGTYRCKA 472
+ CEA+GNP PS H R+ G ++ G G Y+C A
Sbjct: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
Query: 473 ANDQGEAVKD-VTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGE 531
N G A+ + + L V +P + + EG +L C P VI S
Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 179
Query: 532 LGAVIEGLLRVAREHAG--------------TYRCEA----------TNPRGSAAKNVAV 567
+ + + RV++ H G Y C A NP
Sbjct: 180 MEPITQD-KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238
Query: 568 TVEYGPRFEEP-SCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPD 626
E P F P S+ + G L C G P P + GG A +
Sbjct: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS---DKAKFE 295
Query: 627 PSPRAPRIPRVLA--PGIYVCNATNRHGSVAKTVVVSAESPPE-MDESTCPSHQTWLEGA 683
+A RI V G Y C A+N+ GS+ T+ V ++ P +DE P + G
Sbjct: 296 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE---PKNLILAPG- 351
Query: 684 EASALACAARGRPSPGVRCSREGIPWPE-QQRVSREDAG--------------TYHCVAT 728
E L C A G P P V+ G P +RE AG Y C +
Sbjct: 352 EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 411
Query: 729 NAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGAL 788
N HG V V P + V L C P + W
Sbjct: 412 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGS 471
Query: 789 NIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
N+ + N +L + G Y C ATN G+ ++ + V P
Sbjct: 472 NLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
Score = 42.4 bits (98), Expect = 0.002
Identities = 60/266 (22%), Positives = 100/266 (37%), Gaps = 40/266 (15%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L++ +D +FC A+ + + +RV AP D P++ G +
Sbjct: 301 LRITNVSEEDSGEYFCLASNKMGSI----RHTISVRVKAAPYWLDE--PKNLILAPGEDG 354
Query: 428 TLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSG--------------TYRCKAA 473
L C A GNP+P+V + G L P R ++G Y+C +
Sbjct: 355 RLVCRANGNPKPTVQWMVN--GEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTS 411
Query: 474 NDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELG 533
N+ G + + ++V P + I + L C G P P + ++G+ G
Sbjct: 412 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-G 470
Query: 534 AVIEG------------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCP 581
+ ++G + + +E G Y C ATN G A V + V+ R P
Sbjct: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR--MP 528
Query: 582 SNWTWVEGSGRLFSCEVDGKPQPSVK 607
+ G+ C V K PS+K
Sbjct: 529 EDQVARRGTTVQLECRV--KHDPSLK 552
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/80 (30%), Positives = 31/80 (38%), Gaps = 5/80 (6%)
Query: 762 GGNFTLTCRAEAWPPAQISWRAPPGAL---NIGLSSNNSTLSVAGAMGSHGGEYECAATN 818
G + L C A P I+W G L + N L + GEY C A+N
Sbjct: 261 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 320
Query: 819 AHG--RHARRITVRVAGPWL 836
G RH + V+ A WL
Sbjct: 321 KMGSIRHTISVRVKAAPYWL 340
Score = 30.4 bits (67), Expect = 7.9
Identities = 24/90 (26%), Positives = 35/90 (38%), Gaps = 11/90 (12%)
Query: 759 VRPGGNFTLTCRAEAWPPAQISWRAPPGALNIG------LSSNNSTLSV----AGAMGSH 808
V P N + C A+ P W NI + + TL + G +
Sbjct: 53 VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEY 112
Query: 809 GGEYECAATNAHGRH-ARRITVRVAGPWLW 837
GEY+C A N G + RI ++V+ LW
Sbjct: 113 EGEYQCFARNKFGTALSNRIRLQVSKSPLW 142
>gi|237858679 neurofascin isoform 3 precursor [Homo sapiens]
Length = 1174
Score = 90.9 bits (224), Expect = 5e-18
Identities = 95/370 (25%), Positives = 146/370 (39%), Gaps = 58/370 (15%)
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG----ELGAVIEG------LLRVAREHAGTYRCEA 554
L G + L C+A GVP PD+ + G A E + V+ E +G Y C A
Sbjct: 270 LRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLA 329
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
+N GS ++V V+ P + + P N G C +G P+P+V+ +
Sbjct: 330 SNKMGSIRHTISVRVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWM----- 382
Query: 615 TEGVLLPLAPPDPSPRAP------RIPRVLAPGIYVCNATNRHGSVAKTVVVSA-ESPPE 667
G L APP+P+ R ++ + +Y CN +N HG + VS + PP
Sbjct: 383 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 442
Query: 668 MDESTCPSHQ-TWLEGAEASALACAARGRPSPGVRCSREGIPWP--------------EQ 712
M P +Q + + L C G P P +R + G E
Sbjct: 443 M---LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 499
Query: 713 QRVSREDAGTYHCVATNAHGTDSRTVTVGVE-----YRPVVAELAASPPGGVRPGGNFTL 767
+ + +ED G Y CVATN G V + V+ YR ++A R G L
Sbjct: 500 KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA-------RRGTTVQL 552
Query: 768 TCRAEAWPPAQ--ISWRAPPGALNIG--LSSNNSTLSVAGAMGSHGGEYECAATNAHGRH 823
CR + P + +SW L IG + + +L++ G G Y C A+ +
Sbjct: 553 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 612
Query: 824 ARRITVRVAG 833
+ + V G
Sbjct: 613 LAKAYLTVLG 622
Score = 56.6 bits (135), Expect = 1e-07
Identities = 112/490 (22%), Positives = 159/490 (32%), Gaps = 96/490 (19%)
Query: 429 LRCEARGNPEPSVHCARSD----------------GGAVLALGLLGPVTRALSGTYRCKA 472
+ CEA+GNP PS H R+ G ++ G G Y+C A
Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
Query: 473 ANDQGEAVKD-VTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGE 531
N G A+ + + L V +P + + EG +L C P VI S
Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 173
Query: 532 LGAVIEGLLRVAREHAG--------------TYRCEA----------------------- 554
+ + + RV++ H G Y C A
Sbjct: 174 MEPITQD-KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHP 232
Query: 555 -------TNPRGSAAKNVAVTVEYGPRFEEP-SCPSNWTWVEGSGRLFSCEVDGKPQPSV 606
+P +A+ VA E P F P S+ + G L C G P P +
Sbjct: 233 YNDSSLRNHPDMYSARGVA---ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 289
Query: 607 KCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLA--PGIYVCNATNRHGSVAKTVVVSAES 664
GG A + +A RI V G Y C A+N+ GS+ T+ V ++
Sbjct: 290 AWYKKGGDLPS---DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
Query: 665 PPE-MDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPE-QQRVSREDAG- 721
P +DE P + G E L C A G P P V+ G P +RE AG
Sbjct: 347 APYWLDE---PKNLILAPG-EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD 402
Query: 722 -------------TYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLT 768
Y C +N HG V V P + V L
Sbjct: 403 TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLD 462
Query: 769 CRAEAWPPAQISWRAPPGALNIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
C P + W N+ + N +L + G Y C ATN G+
Sbjct: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAE 522
Query: 825 RRITVRVAGP 834
++ + V P
Sbjct: 523 NQVRLEVKDP 532
Score = 51.2 bits (121), Expect = 4e-06
Identities = 86/362 (23%), Positives = 129/362 (35%), Gaps = 48/362 (13%)
Query: 424 GPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRAL---------SGTYRCKAAN 474
G + L C A G P P + + G +AL SG Y C A+N
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 331
Query: 475 DQGEAVKDVTLTVEYAPA-LDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGEL- 532
G +++ V+ AP LD P+ + G + L C A+G P P V + +GE
Sbjct: 332 KMGSIRHTISVRVKAAPYWLDE---PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPL 388
Query: 533 -------GAVIEGLLRVARE----HAGTYRCEATNPRGSAAKNVAVTV-EYGPRFEEPSC 580
+ G + R+ Y+C +N G N V+V + PR P
Sbjct: 389 QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 448
Query: 581 PSNWTWVEGSGRLFSCEVDGKPQPSVKCV--GSGGATEGVLLPLAPPDPSPRAPRIPRVL 638
+ RL C G P P+++ G G +G + + ++ R
Sbjct: 449 QLIRVILYNRTRL-DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVY--ENGSLEIKMIRKE 505
Query: 639 APGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSP 698
GIY C ATN G V + + P + P Q G L C + PS
Sbjct: 506 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRM--PEDQVARRGTTVQ-LECRVKHDPSL 562
Query: 699 GVRCS--REGIPWPEQQRVSRED------------AGTYHCVATNAHGTDSRTVTVGVEY 744
+ S ++ P R+ +ED G+Y CVA+ D + V
Sbjct: 563 KLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 622
Query: 745 RP 746
RP
Sbjct: 623 RP 624
Score = 42.4 bits (98), Expect = 0.002
Identities = 60/266 (22%), Positives = 100/266 (37%), Gaps = 40/266 (15%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L++ +D +FC A+ + + +RV AP D P++ G +
Sbjct: 312 LRITNVSEEDSGEYFCLASNKMGSI----RHTISVRVKAAPYWLDE--PKNLILAPGEDG 365
Query: 428 TLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSG--------------TYRCKAA 473
L C A GNP+P+V + G L P R ++G Y+C +
Sbjct: 366 RLVCRANGNPKPTVQWMVN--GEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTS 422
Query: 474 NDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELG 533
N+ G + + ++V P + I + L C G P P + ++G+ G
Sbjct: 423 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-G 481
Query: 534 AVIEG------------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCP 581
+ ++G + + +E G Y C ATN G A V + V+ R P
Sbjct: 482 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR--MP 539
Query: 582 SNWTWVEGSGRLFSCEVDGKPQPSVK 607
+ G+ C V K PS+K
Sbjct: 540 EDQVARRGTTVQLECRV--KHDPSLK 563
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/80 (30%), Positives = 31/80 (38%), Gaps = 5/80 (6%)
Query: 762 GGNFTLTCRAEAWPPAQISWRAPPGAL---NIGLSSNNSTLSVAGAMGSHGGEYECAATN 818
G + L C A P I+W G L + N L + GEY C A+N
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 331
Query: 819 AHG--RHARRITVRVAGPWL 836
G RH + V+ A WL
Sbjct: 332 KMGSIRHTISVRVKAAPYWL 351
Score = 30.4 bits (67), Expect = 7.9
Identities = 24/90 (26%), Positives = 35/90 (38%), Gaps = 11/90 (12%)
Query: 759 VRPGGNFTLTCRAEAWPPAQISWRAPPGALNIG------LSSNNSTLSV----AGAMGSH 808
V P N + C A+ P W NI + + TL + G +
Sbjct: 47 VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEY 106
Query: 809 GGEYECAATNAHGRH-ARRITVRVAGPWLW 837
GEY+C A N G + RI ++V+ LW
Sbjct: 107 EGEYQCFARNKFGTALSNRIRLQVSKSPLW 136
>gi|89903008 neurofascin isoform 4 precursor [Homo sapiens]
Length = 1169
Score = 90.9 bits (224), Expect = 5e-18
Identities = 95/370 (25%), Positives = 146/370 (39%), Gaps = 58/370 (15%)
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG----ELGAVIEG------LLRVAREHAGTYRCEA 554
L G + L C+A GVP PD+ + G A E + V+ E +G Y C A
Sbjct: 270 LRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLA 329
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
+N GS ++V V+ P + + P N G C +G P+P+V+ +
Sbjct: 330 SNKMGSIRHTISVRVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWM----- 382
Query: 615 TEGVLLPLAPPDPSPRAP------RIPRVLAPGIYVCNATNRHGSVAKTVVVSA-ESPPE 667
G L APP+P+ R ++ + +Y CN +N HG + VS + PP
Sbjct: 383 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 442
Query: 668 MDESTCPSHQ-TWLEGAEASALACAARGRPSPGVRCSREGIPWP--------------EQ 712
M P +Q + + L C G P P +R + G E
Sbjct: 443 M---LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 499
Query: 713 QRVSREDAGTYHCVATNAHGTDSRTVTVGVE-----YRPVVAELAASPPGGVRPGGNFTL 767
+ + +ED G Y CVATN G V + V+ YR ++A R G L
Sbjct: 500 KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA-------RRGTTVQL 552
Query: 768 TCRAEAWPPAQ--ISWRAPPGALNIG--LSSNNSTLSVAGAMGSHGGEYECAATNAHGRH 823
CR + P + +SW L IG + + +L++ G G Y C A+ +
Sbjct: 553 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQD 612
Query: 824 ARRITVRVAG 833
+ + V G
Sbjct: 613 LAKAYLTVLG 622
Score = 56.6 bits (135), Expect = 1e-07
Identities = 112/490 (22%), Positives = 159/490 (32%), Gaps = 96/490 (19%)
Query: 429 LRCEARGNPEPSVHCARSD----------------GGAVLALGLLGPVTRALSGTYRCKA 472
+ CEA+GNP PS H R+ G ++ G G Y+C A
Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
Query: 473 ANDQGEAVKD-VTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGE 531
N G A+ + + L V +P + + EG +L C P VI S
Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 173
Query: 532 LGAVIEGLLRVAREHAG--------------TYRCEA----------------------- 554
+ + + RV++ H G Y C A
Sbjct: 174 MEPITQD-KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHP 232
Query: 555 -------TNPRGSAAKNVAVTVEYGPRFEEP-SCPSNWTWVEGSGRLFSCEVDGKPQPSV 606
+P +A+ VA E P F P S+ + G L C G P P +
Sbjct: 233 YNDSSLRNHPDMYSARGVA---ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 289
Query: 607 KCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLA--PGIYVCNATNRHGSVAKTVVVSAES 664
GG A + +A RI V G Y C A+N+ GS+ T+ V ++
Sbjct: 290 AWYKKGGDLPS---DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
Query: 665 PPE-MDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPE-QQRVSREDAG- 721
P +DE P + G E L C A G P P V+ G P +RE AG
Sbjct: 347 APYWLDE---PKNLILAPG-EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD 402
Query: 722 -------------TYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLT 768
Y C +N HG V V P + V L
Sbjct: 403 TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLD 462
Query: 769 CRAEAWPPAQISWRAPPGALNIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
C P + W N+ + N +L + G Y C ATN G+
Sbjct: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAE 522
Query: 825 RRITVRVAGP 834
++ + V P
Sbjct: 523 NQVRLEVKDP 532
Score = 51.2 bits (121), Expect = 4e-06
Identities = 86/362 (23%), Positives = 129/362 (35%), Gaps = 48/362 (13%)
Query: 424 GPEQTLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRAL---------SGTYRCKAAN 474
G + L C A G P P + + G +AL SG Y C A+N
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 331
Query: 475 DQGEAVKDVTLTVEYAPA-LDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGEL- 532
G +++ V+ AP LD P+ + G + L C A+G P P V + +GE
Sbjct: 332 KMGSIRHTISVRVKAAPYWLDE---PKNLILAPGEDGRLVCRANGNPKPTVQWMVNGEPL 388
Query: 533 -------GAVIEGLLRVARE----HAGTYRCEATNPRGSAAKNVAVTV-EYGPRFEEPSC 580
+ G + R+ Y+C +N G N V+V + PR P
Sbjct: 389 QSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRN 448
Query: 581 PSNWTWVEGSGRLFSCEVDGKPQPSVKCV--GSGGATEGVLLPLAPPDPSPRAPRIPRVL 638
+ RL C G P P+++ G G +G + + ++ R
Sbjct: 449 QLIRVILYNRTRL-DCPFFGSPIPTLRWFKNGQGSNLDGGNYHVY--ENGSLEIKMIRKE 505
Query: 639 APGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSP 698
GIY C ATN G V + + P + P Q G L C + PS
Sbjct: 506 DQGIYTCVATNILGKAENQVRLEVKDPTRIYRM--PEDQVARRGTTVQ-LECRVKHDPSL 562
Query: 699 GVRCS--REGIPWPEQQRVSRED------------AGTYHCVATNAHGTDSRTVTVGVEY 744
+ S ++ P R+ +ED G+Y CVA+ D + V
Sbjct: 563 KLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVASTELDQDLAKAYLTVLG 622
Query: 745 RP 746
RP
Sbjct: 623 RP 624
Score = 42.4 bits (98), Expect = 0.002
Identities = 60/266 (22%), Positives = 100/266 (37%), Gaps = 40/266 (15%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L++ +D +FC A+ + + +RV AP D P++ G +
Sbjct: 312 LRITNVSEEDSGEYFCLASNKMGSI----RHTISVRVKAAPYWLDE--PKNLILAPGEDG 365
Query: 428 TLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSG--------------TYRCKAA 473
L C A GNP+P+V + G L P R ++G Y+C +
Sbjct: 366 RLVCRANGNPKPTVQWMVN--GEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTS 422
Query: 474 NDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELG 533
N+ G + + ++V P + I + L C G P P + ++G+ G
Sbjct: 423 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-G 481
Query: 534 AVIEG------------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCP 581
+ ++G + + +E G Y C ATN G A V + V+ R P
Sbjct: 482 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR--MP 539
Query: 582 SNWTWVEGSGRLFSCEVDGKPQPSVK 607
+ G+ C V K PS+K
Sbjct: 540 EDQVARRGTTVQLECRV--KHDPSLK 563
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/80 (30%), Positives = 31/80 (38%), Gaps = 5/80 (6%)
Query: 762 GGNFTLTCRAEAWPPAQISWRAPPGAL---NIGLSSNNSTLSVAGAMGSHGGEYECAATN 818
G + L C A P I+W G L + N L + GEY C A+N
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 331
Query: 819 AHG--RHARRITVRVAGPWL 836
G RH + V+ A WL
Sbjct: 332 KMGSIRHTISVRVKAAPYWL 351
Score = 30.4 bits (67), Expect = 7.9
Identities = 24/90 (26%), Positives = 35/90 (38%), Gaps = 11/90 (12%)
Query: 759 VRPGGNFTLTCRAEAWPPAQISWRAPPGALNIG------LSSNNSTLSV----AGAMGSH 808
V P N + C A+ P W NI + + TL + G +
Sbjct: 47 VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEY 106
Query: 809 GGEYECAATNAHGRH-ARRITVRVAGPWLW 837
GEY+C A N G + RI ++V+ LW
Sbjct: 107 EGEYQCFARNKFGTALSNRIRLQVSKSPLW 136
>gi|237858677 neurofascin isoform 2 precursor [Homo sapiens]
Length = 1189
Score = 90.5 bits (223), Expect = 6e-18
Identities = 93/354 (26%), Positives = 141/354 (39%), Gaps = 58/354 (16%)
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG----ELGAVIEG------LLRVAREHAGTYRCEA 554
L G + L C+A GVP PD+ + G A E + V+ E +G Y C A
Sbjct: 270 LRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLA 329
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
+N GS ++V V+ P + + P N G C +G P+P+V+ +
Sbjct: 330 SNKMGSIRHTISVRVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWM----- 382
Query: 615 TEGVLLPLAPPDPSPRAP------RIPRVLAPGIYVCNATNRHGSVAKTVVVSA-ESPPE 667
G L APP+P+ R ++ + +Y CN +N HG + VS + PP
Sbjct: 383 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 442
Query: 668 MDESTCPSHQ-TWLEGAEASALACAARGRPSPGVRCSREGIPWP--------------EQ 712
M P +Q + + L C G P P +R + G E
Sbjct: 443 M---LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 499
Query: 713 QRVSREDAGTYHCVATNAHGTDSRTVTVGVE-----YRPVVAELAASPPGGVRPGGNFTL 767
+ + +ED G Y CVATN G V + V+ YR ++A R G L
Sbjct: 500 KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA-------RRGTTVQL 552
Query: 768 TCRAEAWPPAQ--ISWRAPPGALNIG--LSSNNSTLSVAGAMGSHGGEYECAAT 817
CR + P + +SW L IG + + +L++ G G Y C A+
Sbjct: 553 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 606
Score = 56.6 bits (135), Expect = 1e-07
Identities = 112/490 (22%), Positives = 159/490 (32%), Gaps = 96/490 (19%)
Query: 429 LRCEARGNPEPSVHCARSD----------------GGAVLALGLLGPVTRALSGTYRCKA 472
+ CEA+GNP PS H R+ G ++ G G Y+C A
Sbjct: 55 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 114
Query: 473 ANDQGEAVKD-VTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGE 531
N G A+ + + L V +P + + EG +L C P VI S
Sbjct: 115 RNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 173
Query: 532 LGAVIEGLLRVAREHAG--------------TYRCEA----------------------- 554
+ + + RV++ H G Y C A
Sbjct: 174 MEPITQD-KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTNHP 232
Query: 555 -------TNPRGSAAKNVAVTVEYGPRFEEP-SCPSNWTWVEGSGRLFSCEVDGKPQPSV 606
+P +A+ VA E P F P S+ + G L C G P P +
Sbjct: 233 YNDSSLRNHPDMYSARGVA---ERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDI 289
Query: 607 KCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLA--PGIYVCNATNRHGSVAKTVVVSAES 664
GG A + +A RI V G Y C A+N+ GS+ T+ V ++
Sbjct: 290 AWYKKGGDLPS---DKAKFENFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKA 346
Query: 665 PPE-MDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPE-QQRVSREDAG- 721
P +DE P + G E L C A G P P V+ G P +RE AG
Sbjct: 347 APYWLDE---PKNLILAPG-EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGD 402
Query: 722 -------------TYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLT 768
Y C +N HG V V P + V L
Sbjct: 403 TIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLD 462
Query: 769 CRAEAWPPAQISWRAPPGALNIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHA 824
C P + W N+ + N +L + G Y C ATN G+
Sbjct: 463 CPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAE 522
Query: 825 RRITVRVAGP 834
++ + V P
Sbjct: 523 NQVRLEVKDP 532
Score = 42.4 bits (98), Expect = 0.002
Identities = 60/266 (22%), Positives = 100/266 (37%), Gaps = 40/266 (15%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L++ +D +FC A+ + + +RV AP D P++ G +
Sbjct: 312 LRITNVSEEDSGEYFCLASNKMGSI----RHTISVRVKAAPYWLDE--PKNLILAPGEDG 365
Query: 428 TLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSG--------------TYRCKAA 473
L C A GNP+P+V + G L P R ++G Y+C +
Sbjct: 366 RLVCRANGNPKPTVQWMVN--GEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTS 422
Query: 474 NDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELG 533
N+ G + + ++V P + I + L C G P P + ++G+ G
Sbjct: 423 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-G 481
Query: 534 AVIEG------------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCP 581
+ ++G + + +E G Y C ATN G A V + V+ R P
Sbjct: 482 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR--MP 539
Query: 582 SNWTWVEGSGRLFSCEVDGKPQPSVK 607
+ G+ C V K PS+K
Sbjct: 540 EDQVARRGTTVQLECRV--KHDPSLK 563
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/80 (30%), Positives = 31/80 (38%), Gaps = 5/80 (6%)
Query: 762 GGNFTLTCRAEAWPPAQISWRAPPGAL---NIGLSSNNSTLSVAGAMGSHGGEYECAATN 818
G + L C A P I+W G L + N L + GEY C A+N
Sbjct: 272 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 331
Query: 819 AHG--RHARRITVRVAGPWL 836
G RH + V+ A WL
Sbjct: 332 KMGSIRHTISVRVKAAPYWL 351
Score = 30.4 bits (67), Expect = 7.9
Identities = 24/90 (26%), Positives = 35/90 (38%), Gaps = 11/90 (12%)
Query: 759 VRPGGNFTLTCRAEAWPPAQISWRAPPGALNIG------LSSNNSTLSV----AGAMGSH 808
V P N + C A+ P W NI + + TL + G +
Sbjct: 47 VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEY 106
Query: 809 GGEYECAATNAHGRH-ARRITVRVAGPWLW 837
GEY+C A N G + RI ++V+ LW
Sbjct: 107 EGEYQCFARNKFGTALSNRIRLQVSKSPLW 136
>gi|237858675 neurofascin isoform 1 precursor [Homo sapiens]
Length = 1240
Score = 90.5 bits (223), Expect = 6e-18
Identities = 93/354 (26%), Positives = 141/354 (39%), Gaps = 58/354 (16%)
Query: 505 LEGTEASLSCVAHGVPPPDVICVRSG----ELGAVIEG------LLRVAREHAGTYRCEA 554
L G + L C+A GVP PD+ + G A E + V+ E +G Y C A
Sbjct: 259 LRGMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLA 318
Query: 555 TNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGA 614
+N GS ++V V+ P + + P N G C +G P+P+V+ +
Sbjct: 319 SNKMGSIRHTISVRVKAAPYWLDE--PKNLILAPGEDGRLVCRANGNPKPTVQWM----- 371
Query: 615 TEGVLLPLAPPDPSPRAP------RIPRVLAPGIYVCNATNRHGSVAKTVVVSA-ESPPE 667
G L APP+P+ R ++ + +Y CN +N HG + VS + PP
Sbjct: 372 VNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTSNEHGYLLANAFVSVLDVPPR 431
Query: 668 MDESTCPSHQ-TWLEGAEASALACAARGRPSPGVRCSREGIPWP--------------EQ 712
M P +Q + + L C G P P +R + G E
Sbjct: 432 M---LSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGSNLDGGNYHVYENGSLEI 488
Query: 713 QRVSREDAGTYHCVATNAHGTDSRTVTVGVE-----YRPVVAELAASPPGGVRPGGNFTL 767
+ + +ED G Y CVATN G V + V+ YR ++A R G L
Sbjct: 489 KMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYRMPEDQVA-------RRGTTVQL 541
Query: 768 TCRAEAWPPAQ--ISWRAPPGALNIG--LSSNNSTLSVAGAMGSHGGEYECAAT 817
CR + P + +SW L IG + + +L++ G G Y C A+
Sbjct: 542 ECRVKHDPSLKLTVSWLKDDEPLYIGNRMKKEDDSLTIFGVAERDQGSYTCVAS 595
Score = 62.8 bits (151), Expect = 1e-09
Identities = 110/470 (23%), Positives = 154/470 (32%), Gaps = 73/470 (15%)
Query: 429 LRCEARGNPEPSVHCARSD----------------GGAVLALGLLGPVTRALSGTYRCKA 472
+ CEA+GNP PS H R+ G ++ G G Y+C A
Sbjct: 61 IECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEYEGEYQCFA 120
Query: 473 ANDQGEAVKD-VTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGE 531
N G A+ + + L V +P + + EG +L C P VI S
Sbjct: 121 RNKFGTALSNRIRLQVSKSPLWPKENL-DPVVVQEGAPLTLQCNPPPGLPSPVIFWMSSS 179
Query: 532 LGAVIEGLLRVAREHAG--------------TYRCEA----------TNPRGSAAKNVAV 567
+ + + RV++ H G Y C A NP
Sbjct: 180 MEPITQD-KRVSQGHNGDLYFSNVMLQDMQTDYSCNARFHFTHTIQQKNPFTLKVLTTRG 238
Query: 568 TVEYGPRFEEP-SCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPD 626
E P F P S+ + G L C G P P + GG A +
Sbjct: 239 VAERTPSFMYPQGTASSQMVLRGMDLLLECIASGVPTPDIAWYKKGGDLPS---DKAKFE 295
Query: 627 PSPRAPRIPRVLA--PGIYVCNATNRHGSVAKTVVVSAESPPE-MDESTCPSHQTWLEGA 683
+A RI V G Y C A+N+ GS+ T+ V ++ P +DE P + G
Sbjct: 296 NFNKALRITNVSEEDSGEYFCLASNKMGSIRHTISVRVKAAPYWLDE---PKNLILAPG- 351
Query: 684 EASALACAARGRPSPGVRCSREGIPWPE-QQRVSREDAG--------------TYHCVAT 728
E L C A G P P V+ G P +RE AG Y C +
Sbjct: 352 EDGRLVCRANGNPKPTVQWMVNGEPLQSAPPNPNREVAGDTIIFRDTQISSRAVYQCNTS 411
Query: 729 NAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGAL 788
N HG V V P + V L C P + W
Sbjct: 412 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQGS 471
Query: 789 NIGLSS----NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGP 834
N+ + N +L + G Y C ATN G+ ++ + V P
Sbjct: 472 NLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDP 521
Score = 42.4 bits (98), Expect = 0.002
Identities = 60/266 (22%), Positives = 100/266 (37%), Gaps = 40/266 (15%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L++ +D +FC A+ + + +RV AP D P++ G +
Sbjct: 301 LRITNVSEEDSGEYFCLASNKMGSI----RHTISVRVKAAPYWLDE--PKNLILAPGEDG 354
Query: 428 TLRCEARGNPEPSVHCARSDGGAVLALGLLGPVTRALSG--------------TYRCKAA 473
L C A GNP+P+V + G L P R ++G Y+C +
Sbjct: 355 RLVCRANGNPKPTVQWMVN--GEPLQSAPPNP-NREVAGDTIIFRDTQISSRAVYQCNTS 411
Query: 474 NDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELG 533
N+ G + + ++V P + I + L C G P P + ++G+ G
Sbjct: 412 NEHGYLLANAFVSVLDVPPRMLSPRNQLIRVILYNRTRLDCPFFGSPIPTLRWFKNGQ-G 470
Query: 534 AVIEG------------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCP 581
+ ++G + + +E G Y C ATN G A V + V+ R P
Sbjct: 471 SNLDGGNYHVYENGSLEIKMIRKEDQGIYTCVATNILGKAENQVRLEVKDPTRIYR--MP 528
Query: 582 SNWTWVEGSGRLFSCEVDGKPQPSVK 607
+ G+ C V K PS+K
Sbjct: 529 EDQVARRGTTVQLECRV--KHDPSLK 552
Score = 35.4 bits (80), Expect = 0.25
Identities = 24/80 (30%), Positives = 31/80 (38%), Gaps = 5/80 (6%)
Query: 762 GGNFTLTCRAEAWPPAQISWRAPPGAL---NIGLSSNNSTLSVAGAMGSHGGEYECAATN 818
G + L C A P I+W G L + N L + GEY C A+N
Sbjct: 261 GMDLLLECIASGVPTPDIAWYKKGGDLPSDKAKFENFNKALRITNVSEEDSGEYFCLASN 320
Query: 819 AHG--RHARRITVRVAGPWL 836
G RH + V+ A WL
Sbjct: 321 KMGSIRHTISVRVKAAPYWL 340
Score = 30.4 bits (67), Expect = 7.9
Identities = 24/90 (26%), Positives = 35/90 (38%), Gaps = 11/90 (12%)
Query: 759 VRPGGNFTLTCRAEAWPPAQISWRAPPGALNIG------LSSNNSTLSV----AGAMGSH 808
V P N + C A+ P W NI + + TL + G +
Sbjct: 53 VDPRDNILIECEAKGNPAPSFHWTRNSRFFNIAKDPRVSMRRRSGTLVIDFRSGGRPEEY 112
Query: 809 GGEYECAATNAHGRH-ARRITVRVAGPWLW 837
GEY+C A N G + RI ++V+ LW
Sbjct: 113 EGEYQCFARNKFGTALSNRIRLQVSKSPLW 142
>gi|4504561 intercellular adhesion molecule 4 isoform 1 precursor
[Homo sapiens]
Length = 271
Score = 90.5 bits (223), Expect = 6e-18
Identities = 71/208 (34%), Positives = 95/208 (45%), Gaps = 16/208 (7%)
Query: 33 PFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIRE 92
PFW + P V+ G S+ LNCS +CP+P+ L T LR+ T RG W++ QL+D+R
Sbjct: 47 PFWVRMSPEFVAVQPGKSVQLNCSNSCPQPQNSSLRTPLRQGKTLRGPGWVSYQLLDVRA 106
Query: 93 PETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPV--GENFTLSCRVPGAGPR 150
+ C CA +T A I ++ P V L P PV G +TL C V P
Sbjct: 107 WSSLAHCLVTCAGKTRWATSRITAYKPPHSVILEP-----PVLKGRKYTLRCHVTQVFPV 161
Query: 151 ASLTLTLLRGAQELIRRS---FAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPH 207
L +TL G++ + S F G LT A D C A L+L
Sbjct: 162 GYLVVTLRHGSRVIYSESLERFTGLD--LANVTLTYEFAAGPRDFWQPVICHARLNL--D 217
Query: 208 GLGLFENSSAPRELRTFSLSPDAPRLAA 235
GL + NSSAP L + SP LA+
Sbjct: 218 GL-VVRNSSAPITL-MLAWSPAPTALAS 243
>gi|12545402 intercellular adhesion molecule 4 isoform 2 precursor
[Homo sapiens]
Length = 237
Score = 90.1 bits (222), Expect = 8e-18
Identities = 66/191 (34%), Positives = 88/191 (46%), Gaps = 15/191 (7%)
Query: 33 PFWADLQPRVAFVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIRE 92
PFW + P V+ G S+ LNCS +CP+P+ L T LR+ T RG W++ QL+D+R
Sbjct: 47 PFWVRMSPEFVAVQPGKSVQLNCSNSCPQPQNSSLRTPLRQGKTLRGPGWVSYQLLDVRA 106
Query: 93 PETQPVCFFRCARRTLQARGLIRTFQRPDRVELMPLPPWQPV--GENFTLSCRVPGAGPR 150
+ C CA +T A I ++ P V L P PV G +TL C V P
Sbjct: 107 WSSLAHCLVTCAGKTRWATSRITAYKPPHSVILEP-----PVLKGRKYTLRCHVTQVFPV 161
Query: 151 ASLTLTLLRGAQELIRRS---FAGEPPRARGAVLTATVLARREDHGANFSCRAELDLRPH 207
L +TL G++ + S F G LT A D C A L+L
Sbjct: 162 GYLVVTLRHGSRVIYSESLERFTGLD--LANVTLTYEFAAGPRDFWQPVICHARLNL--D 217
Query: 208 GLGLFENSSAP 218
GL + NSSAP
Sbjct: 218 GL-VVRNSSAP 227
>gi|239743951 PREDICTED: hypothetical protein XP_002342997 [Homo
sapiens]
Length = 790
Score = 87.8 bits (216), Expect = 4e-17
Identities = 90/323 (27%), Positives = 133/323 (41%), Gaps = 37/323 (11%)
Query: 539 LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEV 598
+LR ++ GTY C A + G+ + V P P+ N T G + SC V
Sbjct: 482 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPA--PNVTVSPGETAVLSCRV 539
Query: 599 DGKPQPSVKCVGSGG---ATEGVLLPLAPPDPSPRAPRIPRVLAP--GIYVCNATNRHGS 653
G+ ++ V A+ G + LA + I ++ G Y C A+N +G
Sbjct: 540 LGEAPYNLTWVRDWRVLPASTGRVAQLAD-----LSLEISGIIPTDGGRYQCVASNANGV 594
Query: 654 VAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQ 713
+V + P++ T H + +G E ++C+A G P+P + SRE E
Sbjct: 595 TRASVWLLVREAPQVSIHTSSQH--FSQGVEVK-VSCSASGYPTPHISWSRESQALQEDS 651
Query: 714 R-------------VSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVR 760
R V+ EDAG Y C ATN GTD TVT+ P V+ A + V
Sbjct: 652 RIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS--AVNAVVLVA 709
Query: 761 PGGNFTLTCRAEAWPPAQISWRAPPGALNIGLS---SNNSTLSVAGAMGSHGGEYECAAT 817
G L C A PP ++ W G L + L+ S++ L + A G Y C A
Sbjct: 710 VGEEAVLVCEASGVPPPRVIWYR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAV 767
Query: 818 NAHGRHARRITVRV--AGPWLWV 838
N G + I + V G + WV
Sbjct: 768 NELGDASAEIQLAVGRGGGYPWV 790
Score = 75.1 bits (183), Expect = 3e-13
Identities = 101/378 (26%), Positives = 159/378 (42%), Gaps = 46/378 (12%)
Query: 226 LSPDAPRLAAPRLLEVGSERP--VSCTLDGLFPASEARVYLALGDQNLSPDVTLEGDAFV 283
++P AP ++ + +P VSC++ P R+ L G+ L + +
Sbjct: 422 VAPGAPLVSMAPRIHGYLHQPLLVSCSVHSALPF---RLQLRRGEARLGEERHFQESGNS 478
Query: 284 ATATATASAEQEGARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVT 343
+ AS +EG + V+ G R + + + P L+ +VS G+ ++
Sbjct: 479 SWEILRASKAEEGTYECTA-VSRAGTGR-AKAQIVVTDPPPQLVPAPNVTVSPGETAVLS 536
Query: 344 CAAGAQALVTLEGV------PAAVPGQPAQL-----QLNATENDDRRSFFCDATLDVDGE 392
C +A L V PA+ G+ AQL +++ D + C A+ + +G
Sbjct: 537 CRVLGEAPYNLTWVRDWRVLPAST-GRVAQLADLSLEISGIIPTDGGRYQCVAS-NANGV 594
Query: 393 TLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGA-- 450
T S L V AP++ S S + +G E + C A G P P + +R
Sbjct: 595 T---RASVWLLVREAPQV--SIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQE 649
Query: 451 -----VLALG--LLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERIT 503
V A G ++ V +G Y C+A N+ G + VTL P++ +V +
Sbjct: 650 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVVLVA 709
Query: 504 WLEGTEASLSCVAHGVPPPDVICVRSGELGAVI------EGLLRV--AREH-AGTYRCEA 554
G EA L C A GVPPP VI R G L ++ G LR+ A+E AGTY C A
Sbjct: 710 --VGEEAVLVCEASGVPPPRVIWYRGG-LEMILAPEGSSSGKLRIPAAQERDAGTYTCRA 766
Query: 555 TNPRGSAAKNVAVTVEYG 572
N G A+ + + V G
Sbjct: 767 VNELGDASAEIQLAVGRG 784
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 87.4 bits (215), Expect = 5e-17
Identities = 99/412 (24%), Positives = 155/412 (37%), Gaps = 44/412 (10%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L+ A + + + C+ + G ++ EL PR+ P+ G
Sbjct: 207 LKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNC-ERPRITSE--PQDADVTSGNTV 263
Query: 428 TLRCEARGNPEPSVHCARSDGGAVL----ALGLLGPVTRAL-------SGTYRCKAANDQ 476
C A GNP+P + R++ + L LL T + G Y+C A N
Sbjct: 264 YFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVA 323
Query: 477 GEA-VKDVTLTVEYAPALDS-VGCPERITWLEGTEASLSCVAHGVPPPDVICVRSGELGA 534
GE ++VTL +PA + V P+ L G +L C A G PPP + R
Sbjct: 324 GEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPL 383
Query: 535 VIEG-----------LLRVAREHAGTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSN 583
++ + V + +G Y C ATN S + V+ P+F P +
Sbjct: 384 PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQF--TVTPQD 441
Query: 584 WTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIY 643
+EG F CE G P P + G L + R + + G Y
Sbjct: 442 RVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGV-ALHDQGQY 500
Query: 644 VCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCS 703
C A N GS ++ + ++ PS T GA L C+++G P P + +
Sbjct: 501 ECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQ-LPCSSQGEPEPAITWN 559
Query: 704 REGIPWPEQQR-------------VSREDAGTYHCVATNAHGTDSRTVTVGV 742
++G+ E + V DAG Y CVA N G+ S ++ + V
Sbjct: 560 KDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
Score = 80.5 bits (197), Expect = 7e-15
Identities = 93/384 (24%), Positives = 139/384 (36%), Gaps = 69/384 (17%)
Query: 499 PERITWLEGTEASLSCVAHGVPPPDVICVRSGE---------LGAVIEGLLRVAREHA-- 547
P+ G +C A G P P++I +R+ L + +G L +
Sbjct: 252 PQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETD 311
Query: 548 -GTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSC---PSNWTWVEGSGRLFSCEVDGKPQ 603
G Y+C A N G K VT+ Y P+ P N + G C G P
Sbjct: 312 QGIYQCMAKNVAGEV-KTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPP 370
Query: 604 PSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVLAPGIYV------------CNATNRH 651
P + T G PL P PR+ + G+Y+ C+ATN
Sbjct: 371 PRISW------TRGDRTPL------PVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNI 418
Query: 652 GSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPE 711
SV T + ++ P+ + P + +EG C A+G P P + ++ G
Sbjct: 419 DSVHATAFIIVQALPQF--TVTPQDRVVIEGQTVD-FQCEAKGNPPPVIAWTKGGSQLSV 475
Query: 712 QQR-------------VSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGG 758
+R V+ D G Y C A N G S+ V + +P V + AS P
Sbjct: 476 DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIG--SQKVVAHLTVQPRVTPVFASIPSD 533
Query: 759 --VRPGGNFTLTCRAEAWPPAQISWR------APPGALNIGLSSNNSTLSVAGAMGSHGG 810
V G N L C ++ P I+W G +I S L++ + G
Sbjct: 534 TTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHI---SPEGFLTINDVGPADAG 590
Query: 811 EYECAATNAHGRHARRITVRVAGP 834
YEC A N G + + + V P
Sbjct: 591 RYECVARNTIGSASVSMVLSVNVP 614
Score = 58.2 bits (139), Expect = 4e-08
Identities = 74/300 (24%), Positives = 118/300 (39%), Gaps = 46/300 (15%)
Query: 306 LGGENRETRENVTIYSFPAPLLTLSEPSVSE---GQMVTVTCAAGAQALVTLEGVPAAVP 362
+ GE + + + PA + +P +E G+ VT+ C+A +
Sbjct: 322 VAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRT 381
Query: 363 GQPAQLQLNATEND----------DRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDD 412
P ++N T + D + C AT ++D + +A + V P+
Sbjct: 382 PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSV----HATAFIIVQALPQFTV 437
Query: 413 SDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALG----LLGPVTRALSGT- 467
+ P+ EG +CEA+GNP P + A + GG+ L++ +L T +SG
Sbjct: 438 T--PQDRVVIEGQTVDFQCEAKGNPPPVI--AWTKGGSQLSVDRRHLVLSSGTLRISGVA 493
Query: 468 ------YRCKAANDQG--EAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGV 519
Y C+A N G + V +T+ P S+ P T G L C + G
Sbjct: 494 LHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASI--PSDTTVEVGANVQLPCSSQGE 551
Query: 520 PPP-------DVICVRSGELGAVIEGLLR---VAREHAGTYRCEATNPRGSAAKNVAVTV 569
P P V SG+ EG L V AG Y C A N GSA+ ++ ++V
Sbjct: 552 PEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
Score = 37.7 bits (86), Expect = 0.050
Identities = 57/275 (20%), Positives = 97/275 (35%), Gaps = 46/275 (16%)
Query: 241 VGSERPVSCTLDGLFPASEARVYLALGDQNLSP-----DVTLEGDAFVATATATASAEQE 295
VG + C+ G P R+ GD+ P ++T G ++ S E
Sbjct: 355 VGESVTLECSATGHPPP---RISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEY- 410
Query: 296 GARQLVCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAA--------- 346
C+ T ++ + + + P +T + V EGQ V C A
Sbjct: 411 -----ACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIA 465
Query: 347 ----GAQALVTLEGVPAAVPGQPAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAEL 402
G+Q V + + L+++ D+ + C A + + ++ + + +
Sbjct: 466 WTKGGSQLSVDRRHLVLS----SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQP 521
Query: 403 RVLYAPRLDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARSDGGAVLALG------- 455
RV + P T G L C ++G PEP++ DG V G
Sbjct: 522 RVTPV----FASIPSDTTVEVGANVQLPCSSQGEPEPAI-TWNKDGVQVTESGKFHISPE 576
Query: 456 ---LLGPVTRALSGTYRCKAANDQGEAVKDVTLTV 487
+ V A +G Y C A N G A + L+V
Sbjct: 577 GFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
>gi|33519481 neural cell adhesion molecule 2 precursor [Homo
sapiens]
Length = 837
Score = 85.1 bits (209), Expect = 3e-16
Identities = 93/413 (22%), Positives = 151/413 (36%), Gaps = 52/413 (12%)
Query: 465 SGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDV 524
+G YRC+A + +G+ ++ T+ +E L + +G +A + C P P V
Sbjct: 88 AGIYRCQATDAKGQT-QEATVVLEIYQKLTFREVVSPQEFKQGEDAEVVCRVSSSPAPAV 146
Query: 525 ICVRSGELGAVIEG------------LLRVAREHAGTYRCEA-TNPRGSAA-KNVAVTVE 570
+ E I +L + + G YRCE RG +++ V V
Sbjct: 147 SWLYHNEEVTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFRDIIVIVN 206
Query: 571 YGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPR 630
P P N T G FSC G P+P++ +G E + +
Sbjct: 207 VPPAISMPQKSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTEL 266
Query: 631 APRIPRVLAPGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEGAEASALAC 690
R G YVC ATN+ G K + P + + ++T E + + L C
Sbjct: 267 TVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQL---KNETTYENGQVT-LVC 322
Query: 691 AARGRPSPGVRCSR--EGIPWPEQQR---------------------VSREDAGTYHCVA 727
A G P P + R +G + E + V D+G Y C A
Sbjct: 323 DAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEA 382
Query: 728 TNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPAQISWRAPPGA 787
+ G +++ + +EY P ++ G ++C ++ PPA I WR
Sbjct: 383 ASRIGGHQKSMYLDIEYAPKF--ISNQTIYYSWEGNPINISCDVKSNPPASIHWRRDKLV 440
Query: 788 LNIGLSSNNST--------LSVAGAMGSHGGEYECAATNAHGRHARRITVRVA 832
L ++N T L +A + G Y C ATN G + + +A
Sbjct: 441 LPAKNTTNLKTYSTGRKMILEIAPTSDNDFGRYNCTATNHIGTRFQEYILALA 493
Score = 65.5 bits (158), Expect = 2e-10
Identities = 72/316 (22%), Positives = 113/316 (35%), Gaps = 45/316 (14%)
Query: 545 EHAGTYRCEATNPRGSAAKNVAVTVEYGP-RFEEPSCPSNWTWVEGSGRLFSCEVDGKPQ 603
E AG YRC+AT+ +G + V Y F E P + +G C V P
Sbjct: 86 EDAGIYRCQATDAKGQTQEATVVLEIYQKLTFREVVSPQEFK--QGEDAEVVCRVSSSPA 143
Query: 604 PSVKCVGSGGATEGVLLPLAPPDPSPRAPRIPRVL-----APGIYVCNA-TNRHGSV-AK 656
P+V + + ++ + A ++L GIY C G + +
Sbjct: 144 PAVSWLYHNEE----VTTISDNRFAMLANNNLQILNINKSDEGIYRCEGRVEARGEIDFR 199
Query: 657 TVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPSPGVRCSREGIPWPEQQR-- 714
++V PP + S E E +C A G P P + R G E ++
Sbjct: 200 DIIVIVNVPPAISMPQ-KSFNATAERGEEMTFSCRASGSPEPAISWFRNGKLIEENEKYI 258
Query: 715 ------------VSREDAGTYHCVATNAHGTDSRTVTVGVEYRPVVAELAASPPGGVRPG 762
+ D G Y C ATN G D + + V +P + +L
Sbjct: 259 LKGSNTELTVRNIINSDGGPYVCRATNKAGEDEKQAFLQVFVQPHIIQLKNET---TYEN 315
Query: 763 GNFTLTCRAEAWPPAQISW-------------RAPPGALNIGLSSNNSTLSVAGAMGSHG 809
G TL C AE P +I+W ++ G + + +S+L + S
Sbjct: 316 GQVTLVCDAEGEPIPEITWKRAVDGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDS 375
Query: 810 GEYECAATNAHGRHAR 825
G Y+C A + G H +
Sbjct: 376 GRYDCEAASRIGGHQK 391
Score = 63.9 bits (154), Expect = 6e-10
Identities = 65/270 (24%), Positives = 107/270 (39%), Gaps = 39/270 (14%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
LQ+ D + C+ ++ GE I R + V P + + T G E
Sbjct: 171 LQILNINKSDEGIYRCEGRVEARGE--IDFRDIIVIVNVPPAISMPQKSFNATAERGEEM 228
Query: 428 TLRCEARGNPEPSVHCARS-----DGGAVLALG-----LLGPVTRALSGTYRCKAANDQG 477
T C A G+PEP++ R+ + + G + + + G Y C+A N G
Sbjct: 229 TFSCRASGSPEPAISWFRNGKLIEENEKYILKGSNTELTVRNIINSDGGPYVCRATNKAG 288
Query: 478 EAVKDVTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRS------GE 531
E K L V P + + + T E + +L C A G P P++ R+ E
Sbjct: 289 EDEKQAFLQVFVQPHIIQL---KNETTYENGQVTLVCDAEGEPIPEITWKRAVDGFTFTE 345
Query: 532 LGAVIEGLLRVAREH--------------AGTYRCEATNPRGSAAKNVAVTVEYGPRF-E 576
++G + V +H +G Y CEA + G K++ + +EY P+F
Sbjct: 346 GDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGHQKSMYLDIEYAPKFIS 405
Query: 577 EPSCPSNWTWVEGSGRLFSCEVDGKPQPSV 606
+ +W EG+ SC+V P S+
Sbjct: 406 NQTIYYSW---EGNPINISCDVKSNPPASI 432
Score = 33.5 bits (75), Expect = 0.94
Identities = 47/227 (20%), Positives = 80/227 (35%), Gaps = 44/227 (19%)
Query: 301 VCNVTLGGENRETRENVTIYSFPAPLLTLSEPSVSEGQMVTVTCAAGAQALVTLEGVPAA 360
VC T E + + ++ P + +E + GQ VT+ C A + + + A
Sbjct: 280 VCRATNKAGEDEKQAFLQVFVQPHIIQLKNETTYENGQ-VTLVCDAEGEPIPEITWKRAV 338
Query: 361 -----------------VPGQ--PAQLQLNATENDDRRSFFCDATLDVDGETLIKNRSAE 401
V GQ + L + + D + C+A + G +S
Sbjct: 339 DGFTFTEGDKSLDGRIEVKGQHGSSSLHIKDVKLSDSGRYDCEAASRIGGH----QKSMY 394
Query: 402 LRVLYAPR-LDDSDCPRSWTWPEGPEQTLRCEARGNPEPSVHCARS-------------- 446
L + YAP+ + + SW EG + C+ + NP S+H R
Sbjct: 395 LDIEYAPKFISNQTIYYSW---EGNPINISCDVKSNPPASIHWRRDKLVLPAKNTTNLKT 451
Query: 447 -DGGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKDVTLTVEYAPA 492
G + L + P + G Y C A N G ++ L + P+
Sbjct: 452 YSTGRKMILE-IAPTSDNDFGRYNCTATNHIGTRFQEYILALADVPS 497
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 84.3 bits (207), Expect = 5e-16
Identities = 107/419 (25%), Positives = 160/419 (38%), Gaps = 70/419 (16%)
Query: 377 DRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEA-RG 435
D S+ C A + GE + +N S E+ +L R D P G L C+ RG
Sbjct: 120 DEGSYVCVAR-NYLGEAVSRNASLEVALL---RDDFRQNPTDVVVAAGEPAILECQPPRG 175
Query: 436 NPEPSVHCARSD-------------GGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKD 482
+PEP+++ + GG ++ + ++ +G Y C N GE D
Sbjct: 176 HPEPTIYWKKDKVRIDDKEERISIRGGKLM----ISNTRKSDAGMYTCVGTNMVGERDSD 231
Query: 483 -VTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRS------GELGAV 535
LTV P + P LE C G P P V + G
Sbjct: 232 PAELTVFERPTF--LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK 289
Query: 536 IEGLLRVAREHA---GTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGR 592
+ LR+ + + GTY C A N G + +TV P+F P + +G
Sbjct: 290 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR--PRDQIVAQGRTV 347
Query: 593 LFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIP---------RVLAPGIY 643
F CE G PQP+V G ++ +L P P P+ R P + G Y
Sbjct: 348 TFPCETKGNPQPAVFWQKEG--SQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 405
Query: 644 VCNATNRHGSVAK------TVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPS 697
+C A GS+ T V++ PP + + P++QT A L C A G P
Sbjct: 406 ICQALTVAGSILAKAQLEVTDVLTDRPPPIILQG--PANQTLAVDGTA-LLKCKATGDPL 462
Query: 698 PGVRCSREGIPWPEQ--------------QRVSREDAGTYHCVATNAHGTDSRTVTVGV 742
P + +EG +P + + + D GTY CVAT++ G S + + V
Sbjct: 463 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 521
Score = 82.0 bits (201), Expect = 2e-15
Identities = 117/468 (25%), Positives = 168/468 (35%), Gaps = 85/468 (18%)
Query: 423 EGPEQTLRCEARGNPEPSV------------------HCARSDGGAVLALGLL-GPVTRA 463
+G TL C+A G P P++ H G++ L ++ G ++
Sbjct: 60 KGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP 119
Query: 464 LSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGC-PERITWLEGTEASLSCVA-HGVPP 521
G+Y C A N GEAV ++E A D P + G A L C G P
Sbjct: 120 DEGSYVCVARNYLGEAVSR-NASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPE 178
Query: 522 PDV---------------ICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVA 566
P + I +R G+L + + AG Y C TN G + A
Sbjct: 179 PTIYWKKDKVRIDDKEERISIRGGKLM-----ISNTRKSDAGMYTCVGTNMVGERDSDPA 233
Query: 567 -VTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPP 625
+TV P F P N +E F C+V G PQP+V+ + LP
Sbjct: 234 ELTVFERPTFLRR--PINQVVLEEEAVEFRCQVQGDPQPTVR-----WKKDDADLPRGRY 286
Query: 626 D-PSPRAPRIPRVLA--PGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEG 682
D RI + ++ G Y+C A NR G + + ++ +PP+ P Q +G
Sbjct: 287 DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF--VVRPRDQIVAQG 344
Query: 683 AEASALACAARGRPSPGVRCSREG---IPWPEQQR------------------VSREDAG 721
+ C +G P P V +EG + +P Q + + R DAG
Sbjct: 345 RTVT-FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 403
Query: 722 TYHCVATNAHGT----DSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPA 777
Y C A G+ VT + RP L + G L C+A P
Sbjct: 404 YYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP 463
Query: 778 QISWRAP----PGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHG 821
ISW PG TL + S G Y C AT++ G
Sbjct: 464 VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 511
Score = 48.9 bits (115), Expect = 2e-05
Identities = 69/301 (22%), Positives = 106/301 (35%), Gaps = 51/301 (16%)
Query: 570 EYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSP 629
++ PR E PS+ +G +C+ +G+P P+++ G E
Sbjct: 44 DFPPRIVEH--PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE----------TDK 91
Query: 630 RAPRIPRVLAP-------------------GIYVCNATNRHGSVAKTVVVSAESPPEMDE 670
PR R+L P G YVC A N G A + S E D+
Sbjct: 92 DDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGE-AVSRNASLEVALLRDD 150
Query: 671 STCPSHQTWLEGAEASALACAA-RGRPSPGVRCSREGIPWPE-QQRVS------------ 716
+ E + L C RG P P + ++ + + ++R+S
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTR 210
Query: 717 REDAGTYHCVATNAHGT-DSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWP 775
+ DAG Y CV TN G DS + V RP + F C+ + P
Sbjct: 211 KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFR--CQVQGDP 268
Query: 776 PAQISWRAPPGALNIGLSS--NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAG 833
+ W+ L G ++ TL + M + G Y C A N G+ T+ V
Sbjct: 269 QPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA 328
Query: 834 P 834
P
Sbjct: 329 P 329
Score = 40.4 bits (93), Expect = 0.008
Identities = 57/235 (24%), Positives = 92/235 (39%), Gaps = 40/235 (17%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L++ T + D ++ C A V SA L V P+ PR +G
Sbjct: 294 LRIKKTMSTDEGTYMCIAENRVGK----MEASATLTVRAPPQFVVR--PRDQIVAQGRTV 347
Query: 428 TLRCEARGNPEPSVHCARSDGGAVL------------ALGLLGPVT-----RALSGTYRC 470
T CE +GNP+P+V + +L ++ G +T R+ +G Y C
Sbjct: 348 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYIC 407
Query: 471 KAANDQGEAVKDVTLTV-----EYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVI 525
+A G + L V + P + G + ++GT A L C A G P P +
Sbjct: 408 QALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT-ALLKCKATGDPLPVIS 466
Query: 526 CVRSG------ELGAVI--EGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTV 569
++ G + A I +G L++ GTY C AT+ G + + + V
Sbjct: 467 WLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 521
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 84.3 bits (207), Expect = 5e-16
Identities = 107/419 (25%), Positives = 160/419 (38%), Gaps = 70/419 (16%)
Query: 377 DRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQTLRCEA-RG 435
D S+ C A + GE + +N S E+ +L R D P G L C+ RG
Sbjct: 104 DEGSYVCVAR-NYLGEAVSRNASLEVALL---RDDFRQNPTDVVVAAGEPAILECQPPRG 159
Query: 436 NPEPSVHCARSD-------------GGAVLALGLLGPVTRALSGTYRCKAANDQGEAVKD 482
+PEP+++ + GG ++ + ++ +G Y C N GE D
Sbjct: 160 HPEPTIYWKKDKVRIDDKEERISIRGGKLM----ISNTRKSDAGMYTCVGTNMVGERDSD 215
Query: 483 -VTLTVEYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVICVRS------GELGAV 535
LTV P + P LE C G P P V + G
Sbjct: 216 PAELTVFERPTF--LRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIK 273
Query: 536 IEGLLRVAREHA---GTYRCEATNPRGSAAKNVAVTVEYGPRFEEPSCPSNWTWVEGSGR 592
+ LR+ + + GTY C A N G + +TV P+F P + +G
Sbjct: 274 DDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVR--PRDQIVAQGRTV 331
Query: 593 LFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSPRAPRIP---------RVLAPGIY 643
F CE G PQP+V G ++ +L P P P+ R P + G Y
Sbjct: 332 TFPCETKGNPQPAVFWQKEG--SQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYY 389
Query: 644 VCNATNRHGSVAK------TVVVSAESPPEMDESTCPSHQTWLEGAEASALACAARGRPS 697
+C A GS+ T V++ PP + + P++QT A L C A G P
Sbjct: 390 ICQALTVAGSILAKAQLEVTDVLTDRPPPIILQG--PANQTLAVDGTA-LLKCKATGDPL 446
Query: 698 PGVRCSREGIPWPEQ--------------QRVSREDAGTYHCVATNAHGTDSRTVTVGV 742
P + +EG +P + + + D GTY CVAT++ G S + + V
Sbjct: 447 PVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
Score = 82.0 bits (201), Expect = 2e-15
Identities = 117/468 (25%), Positives = 168/468 (35%), Gaps = 85/468 (18%)
Query: 423 EGPEQTLRCEARGNPEPSV------------------HCARSDGGAVLALGLL-GPVTRA 463
+G TL C+A G P P++ H G++ L ++ G ++
Sbjct: 44 KGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKP 103
Query: 464 LSGTYRCKAANDQGEAVKDVTLTVEYAPALDSVGC-PERITWLEGTEASLSCVA-HGVPP 521
G+Y C A N GEAV ++E A D P + G A L C G P
Sbjct: 104 DEGSYVCVARNYLGEAVSR-NASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPE 162
Query: 522 PDV---------------ICVRSGELGAVIEGLLRVAREHAGTYRCEATNPRGSAAKNVA 566
P + I +R G+L + + AG Y C TN G + A
Sbjct: 163 PTIYWKKDKVRIDDKEERISIRGGKLM-----ISNTRKSDAGMYTCVGTNMVGERDSDPA 217
Query: 567 -VTVEYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPP 625
+TV P F P N +E F C+V G PQP+V+ + LP
Sbjct: 218 ELTVFERPTFLRR--PINQVVLEEEAVEFRCQVQGDPQPTVR-----WKKDDADLPRGRY 270
Query: 626 D-PSPRAPRIPRVLA--PGIYVCNATNRHGSVAKTVVVSAESPPEMDESTCPSHQTWLEG 682
D RI + ++ G Y+C A NR G + + ++ +PP+ P Q +G
Sbjct: 271 DIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQF--VVRPRDQIVAQG 328
Query: 683 AEASALACAARGRPSPGVRCSREG---IPWPEQQR------------------VSREDAG 721
+ C +G P P V +EG + +P Q + + R DAG
Sbjct: 329 RTVT-FPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAG 387
Query: 722 TYHCVATNAHGT----DSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWPPA 777
Y C A G+ VT + RP L + G L C+A P
Sbjct: 388 YYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLP 447
Query: 778 QISWRAP----PGALNIGLSSNNSTLSVAGAMGSHGGEYECAATNAHG 821
ISW PG TL + S G Y C AT++ G
Sbjct: 448 VISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSG 495
Score = 48.9 bits (115), Expect = 2e-05
Identities = 69/301 (22%), Positives = 106/301 (35%), Gaps = 51/301 (16%)
Query: 570 EYGPRFEEPSCPSNWTWVEGSGRLFSCEVDGKPQPSVKCVGSGGATEGVLLPLAPPDPSP 629
++ PR E PS+ +G +C+ +G+P P+++ G E
Sbjct: 28 DFPPRIVEH--PSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVE----------TDK 75
Query: 630 RAPRIPRVLAP-------------------GIYVCNATNRHGSVAKTVVVSAESPPEMDE 670
PR R+L P G YVC A N G A + S E D+
Sbjct: 76 DDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGE-AVSRNASLEVALLRDD 134
Query: 671 STCPSHQTWLEGAEASALACAA-RGRPSPGVRCSREGIPWPE-QQRVS------------ 716
+ E + L C RG P P + ++ + + ++R+S
Sbjct: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTR 194
Query: 717 REDAGTYHCVATNAHGT-DSRTVTVGVEYRPVVAELAASPPGGVRPGGNFTLTCRAEAWP 775
+ DAG Y CV TN G DS + V RP + F C+ + P
Sbjct: 195 KSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFR--CQVQGDP 252
Query: 776 PAQISWRAPPGALNIGLSS--NNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAG 833
+ W+ L G ++ TL + M + G Y C A N G+ T+ V
Sbjct: 253 QPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRA 312
Query: 834 P 834
P
Sbjct: 313 P 313
Score = 40.4 bits (93), Expect = 0.008
Identities = 57/235 (24%), Positives = 92/235 (39%), Gaps = 40/235 (17%)
Query: 368 LQLNATENDDRRSFFCDATLDVDGETLIKNRSAELRVLYAPRLDDSDCPRSWTWPEGPEQ 427
L++ T + D ++ C A V SA L V P+ PR +G
Sbjct: 278 LRIKKTMSTDEGTYMCIAENRVGK----MEASATLTVRAPPQFVVR--PRDQIVAQGRTV 331
Query: 428 TLRCEARGNPEPSVHCARSDGGAVL------------ALGLLGPVT-----RALSGTYRC 470
T CE +GNP+P+V + +L ++ G +T R+ +G Y C
Sbjct: 332 TFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYIC 391
Query: 471 KAANDQGEAVKDVTLTV-----EYAPALDSVGCPERITWLEGTEASLSCVAHGVPPPDVI 525
+A G + L V + P + G + ++GT A L C A G P P +
Sbjct: 392 QALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGT-ALLKCKATGDPLPVIS 450
Query: 526 CVRSG------ELGAVI--EGLLRVAR---EHAGTYRCEATNPRGSAAKNVAVTV 569
++ G + A I +G L++ GTY C AT+ G + + + V
Sbjct: 451 WLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDV 505
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 42,353,578
Number of Sequences: 37866
Number of extensions: 2266348
Number of successful extensions: 18392
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 178
Number of HSP's successfully gapped in prelim test: 339
Number of HSP's that attempted gapping in prelim test: 11660
Number of HSP's gapped (non-prelim): 3719
length of query: 924
length of database: 18,247,518
effective HSP length: 112
effective length of query: 812
effective length of database: 14,006,526
effective search space: 11373299112
effective search space used: 11373299112
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.