Search of human proteins with 189491763

Search of human proteins with 189491763

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189491763 cytochrome P450, family 1, subfamily B,
polypeptide 1 [Homo sapiens]
         (543 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide...  1094   0.0  
gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1...   367   e-101
gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide ...   349   4e-96
gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide ...   271   1e-72
gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide ...   246   3e-65
gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide ...   243   2e-64
gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18 ...   243   4e-64
gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6...   241   1e-63
gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide ...   238   1e-62
gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 1...   230   2e-60
gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide ...   229   5e-60
gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide ...   225   9e-59
gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide ...   224   1e-58
gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide ...   220   2e-57
gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide ...   214   2e-55
gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide...   211   1e-54
gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide ...   210   2e-54
gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide ...   208   9e-54
gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide ...   207   3e-53
gi|4503195 cytochrome P450, family 17 [Homo sapiens]                  206   3e-53
gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide ...   202   6e-52
gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18...   199   7e-51
gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide ...   160   3e-39
gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide...   151   1e-36
gi|190570174 cytochrome P450, family 21, subfamily A, polypeptid...   122   8e-28
gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1 ...    99   8e-21
gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5...    92   9e-19
gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide ...    89   1e-17
gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7...    85   1e-16
gi|167466231 cytochrome P450, family 27, subfamily C, polypeptid...    85   1e-16

>gi|189491763 cytochrome P450, family 1, subfamily B, polypeptide 1
           [Homo sapiens]
          Length = 543

 Score = 1094 bits (2830), Expect = 0.0
 Identities = 543/543 (100%), Positives = 543/543 (100%)

Query: 1   MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60
           MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI
Sbjct: 1   MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLI 60

Query: 61  GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120
           GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF
Sbjct: 61  GNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAF 120

Query: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180
           ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL
Sbjct: 121 ASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVAL 180

Query: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240
           LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL
Sbjct: 181 LVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSL 240

Query: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA 300
           VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA
Sbjct: 241 VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSA 300

Query: 301 EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL 360
           EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL
Sbjct: 301 EKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAEL 360

Query: 361 DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV 420
           DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV
Sbjct: 361 DQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVV 420

Query: 421 FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL 480
           FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL
Sbjct: 421 FVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQL 480

Query: 481 FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE 540
           FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE
Sbjct: 481 FLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKE 540

Query: 541 TCQ 543
           TCQ
Sbjct: 541 TCQ 543


>gi|4503199 cytochrome P450, family 1, subfamily A, polypeptide 1
           [Homo sapiens]
          Length = 512

 Score =  367 bits (941), Expect = e-101
 Identities = 202/504 (40%), Positives = 294/504 (58%), Gaps = 10/504 (1%)

Query: 13  LNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHL 72
           L P+S+  T  LL   +   V    R  R +  +    PPGP+ WPLIG+   +G+  HL
Sbjct: 2   LFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHL 61

Query: 73  SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSM 132
           + +R++++YGDV QIR+GS P+VVL+G   I QALV+QG  F  RP   +F ++S G+SM
Sbjct: 62  ALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSM 121

Query: 133 AFGHYSEH-WKVQRRAAHSMMRNF-FTRQPRSRQ--VLEGHVLSEARELVALLVRGSADG 188
           +F   S   W  +RR A + +++F     P S     LE HV  EA  L++ L    A  
Sbjct: 122 SFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGP 181

Query: 189 AFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQ 248
              +P    VV+V NV+ A+CFG RY H+  E   L++ N  FG  VG+G+  D +P L+
Sbjct: 182 GHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILR 241

Query: 249 YFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDS 308
           Y PNP    F++   LN  F +F+      H ++   G   RD+ D+ I   ++K   ++
Sbjct: 242 YLPNPSLNAFKD---LNEKFYSFMQKMVKEHYKTFEKGHI-RDITDSLIEHCQEKQLDEN 297

Query: 309 HGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDR 368
                +L  E +   + D+FGA  DT++TA+ W L+     P VQ ++Q ELD V+GR R
Sbjct: 298 --ANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSR 355

Query: 369 LPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVN 428
            P + D+ +LPY+ AF+ E  R SSFVP TIPH+TT +TS+ G++IPK   VFVNQW +N
Sbjct: 356 RPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQIN 415

Query: 429 HDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILA 488
           HD   W NP  F P RFL  DG I+K L+ +V+IF +GKR+CIGE +++ ++FLF++IL 
Sbjct: 416 HDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILL 475

Query: 489 HQCDFRANPNEPAKMNFSYGLTIK 512
            + +F         M   YGLT+K
Sbjct: 476 QRVEFSVPLGVKVDMTPIYGLTMK 499


>gi|73915100 cytochrome P450, family 1, subfamily A, polypeptide 2
           [Homo sapiens]
          Length = 516

 Score =  349 bits (895), Expect = 4e-96
 Identities = 194/497 (39%), Positives = 282/497 (56%), Gaps = 13/497 (2%)

Query: 21  TTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARR 80
           T LLL  ++   V    + LR R  +   +PP P+ WPL+G+   +G+  HL+ +R+++R
Sbjct: 12  TELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQR 71

Query: 81  YGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH 140
           YGDV QIR+GS P++VL+    I QALV+QG  F  RP   +  +++ G+S+ F   S  
Sbjct: 72  YGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGP 131

Query: 141 -WKVQRRAAHSMMRNF-FTRQPRSRQ--VLEGHVLSEARELVALLVRGSADGAFLDPRPL 196
            W  +RR A + +  F     P S     LE HV  EA+ L++ L    A     DP   
Sbjct: 132 VWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQ 191

Query: 197 TVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRT 256
            VV+VANV+ A+CFG  +     E   L+ +  EF  T  +G+ +D  P L+Y PNP   
Sbjct: 192 VVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQ 251

Query: 257 VFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLD 316
            F+ F   N+ F  F+      H +     +  RD+  A    ++K         G  + 
Sbjct: 252 RFKAF---NQRFLWFLQKTVQEHYQDFDKNSV-RDITGALFKHSKK----GPRASGNLIP 303

Query: 317 LENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQP 376
            E +   + DIFGA  DT++TA+ W L+     P++Q ++Q ELD V+GR+R P + D+P
Sbjct: 304 QEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRP 363

Query: 377 NLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPN 436
            LPY+ AF+ E  R SSF+P TIPH+TT +T++ G++IPK   VFVNQW VNHDP  W +
Sbjct: 364 QLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWED 423

Query: 437 PENFDPARFLDKDG-LINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRA 495
           P  F P RFL  DG  INK L+ ++M+F +GKRRCIGE L+K ++FLF++IL  Q +F  
Sbjct: 424 PSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSV 483

Query: 496 NPNEPAKMNFSYGLTIK 512
            P     +   YGLT+K
Sbjct: 484 PPGVKVDLTPIYGLTMK 500


>gi|34098959 cytochrome P450, family 2, subfamily U, polypeptide 1
           [Homo sapiens]
          Length = 544

 Score =  271 bits (692), Expect = 1e-72
 Identities = 167/510 (32%), Positives = 267/510 (52%), Gaps = 46/510 (9%)

Query: 43  RRRQLRSAPPGPFAWPLIGN---------------------AAAVGQAA---HLSFARLA 78
           RRR+ R  PPGP  WPL+GN                     AA +  +     +  A LA
Sbjct: 52  RRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLA 111

Query: 79  RRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYS 138
           R YG +F   +G   +VVL+   ++ +ALVQQ   F+DRP      +V+  + + F HY 
Sbjct: 112 RVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYG 171

Query: 139 EHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTV 198
             W+ QR+ +HS +R+F       +  LE  ++ E + + A + +   D     P  +  
Sbjct: 172 PVWRQQRKFSHSTLRHFGL----GKLSLEPKIIEEFKYVKAEMQKHGEDP--FCPFSIIS 225

Query: 199 VAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGS---LVDVMPWLQYFP-NPV 254
            AV+N++ ++CFG R+ + + EF+++L      G  +   S   LV++ PWL Y P  P 
Sbjct: 226 NAVSNIICSLCFGQRFDYTNSEFKKMLGFMSR-GLEICLNSQVLLVNICPWLYYLPFGP- 283

Query: 255 RTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGAR 314
              F+E  Q+ ++ ++F+      H ESL     P+D +D ++L  E++   +S+     
Sbjct: 284 ---FKELRQIEKDITSFLKKIIKDHQESL-DRENPQDFIDMYLLHMEEERKNNSNSS--- 336

Query: 315 LDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGD 374
            D E +   I D+F A  DT + +L W LL  +  PDVQ +V  E+++V+G +R P + D
Sbjct: 337 FDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTD 396

Query: 375 QPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKW 434
           +  +PY  A + E  R +  VP+ IPH T+ NT + GY IPK T++  N WSV+ DP  W
Sbjct: 397 KAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIW 456

Query: 435 PNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFL-FISILAHQCDF 493
             PE+F P RFLD  G + K  T   + F +GKR C+GE+L+KM+LFL F+S++      
Sbjct: 457 EKPEDFYPNRFLDDQGQLIKKET--FIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFA 514

Query: 494 RANPNEPAKMNFSYGLTIKPKSFKVNVTLR 523
               ++   +   +GLT+ P  F + ++ R
Sbjct: 515 LPEDSKKPLLTGRFGLTLAPHPFNITISRR 544


>gi|18491008 cytochrome P450, family 2, subfamily J, polypeptide 2
           [Homo sapiens]
          Length = 502

 Score =  246 bits (629), Expect = 3e-65
 Identities = 149/482 (30%), Positives = 256/482 (53%), Gaps = 27/482 (5%)

Query: 43  RRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGER 101
           +RR+ ++ PPGP+  P +GN   V  + +HL      ++YG++F + LG    V++ G  
Sbjct: 36  KRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLP 95

Query: 102 AIHQALVQQGSAFADRPAFASFRVV--SGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQ 159
            I +AL+     F +RP       +    G  M+ G   + WK QRR   + +RNF    
Sbjct: 96  LIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSG---QAWKEQRRFTLTALRNFGL-- 150

Query: 160 PRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDP 219
              ++ LE  +  EA+ L   +     +G   DP      AV+N++ ++ FG R+ + D 
Sbjct: 151 --GKKSLEERIQEEAQHLTEAIKE--ENGQPFDPHFKINNAVSNIICSITFGERFEYQDS 206

Query: 220 EFRELLSHNEEFGRTVGAGS--LVDVMPWLQYF-PNPVRTVFREFEQLNRNFSNFILDKF 276
            F++LL   +E      + +  L +V PW+  F P P +T+F  +++L + F + ++DK 
Sbjct: 207 WFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKL-KLFVSHMIDK- 264

Query: 277 LRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLS 336
             H +   P A  RD +DA++    K     +    +    EN+  +  D+F A  +T S
Sbjct: 265 --HRKDWNP-AETRDFIDAYLKEMSKHTGNPT----SSFHEENLICSTLDLFFAGTETTS 317

Query: 337 TALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVP 396
           T L+W LL    YP++Q +VQAE+D+V+G+ + P    + ++PY  A ++E  R  + +P
Sbjct: 318 TTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIP 377

Query: 397 VTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDL 456
           + +P   T +T++ GYH+PK T++  N  +++ DP +W  P+ F+P  FL+ +G   K  
Sbjct: 378 LNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLE-NGQFKK-- 434

Query: 457 TSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSF 516
               M FS+GKR C+GE+L++ +LF+F + L  +  FR   NE   + F  G+TI P S 
Sbjct: 435 REAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSH 494

Query: 517 KV 518
           ++
Sbjct: 495 RL 496


>gi|40805836 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 1 [Homo sapiens]
          Length = 497

 Score =  243 bits (621), Expect = 2e-64
 Identities = 171/495 (34%), Positives = 241/495 (48%), Gaps = 34/495 (6%)

Query: 13  LNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAH 71
           L PL++     LLL+           L+ +R+R     PPGP   P +GN   V  Q   
Sbjct: 6   LVPLAVIVAIFLLLVD----------LMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTP 55

Query: 72  LSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGG-- 129
             F +L RR+GDVF ++L   P+VVLNG  A+ +ALV  G   ADRP     +++  G  
Sbjct: 56  YCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPR 115

Query: 130 -RSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADG 188
            + +    Y   W+ QRR + S +RN        ++ LE  V  EA  L A     S  G
Sbjct: 116 SQGVFLARYGPAWREQRRFSVSTLRNLGL----GKKSLEQWVTEEAACLCAAFANHS--G 169

Query: 189 AFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVM---P 245
               P  L   AV+NV++++  G R+ +DDP F  LL   +E G    +G L +V+   P
Sbjct: 170 RPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVP 228

Query: 246 WLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAA 305
            L + P     V R      + F   + +    H  +  P   PRD+ +AF+   EK A 
Sbjct: 229 VLLHIPALAGKVLR----FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK-AK 283

Query: 306 GDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVG 365
           G+        + EN+   + D+F A   T ST L W LLL   +PDVQ RVQ E+D V+G
Sbjct: 284 GNPESS---FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIG 340

Query: 366 RDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQW 425
           + R P MGDQ ++PY  A ++E  RF   VP+ + H T+ +  V G+ IPK T +  N  
Sbjct: 341 QVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLS 400

Query: 426 SVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFIS 485
           SV  D   W  P  F P  FLD  G   K      + FS G+R C+GE L++M+LFLF +
Sbjct: 401 SVLKDEAVWEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFT 458

Query: 486 ILAHQCDFRANPNEP 500
            L     F     +P
Sbjct: 459 SLLQHFSFSVPTGQP 473


>gi|13699816 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 1 [Homo sapiens]
          Length = 490

 Score =  243 bits (619), Expect = 4e-64
 Identities = 153/452 (33%), Positives = 240/452 (53%), Gaps = 28/452 (6%)

Query: 51  PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109
           P GP   P+IGN   +  +    S    ++ YG VF +  G  PIVVL+G  A+ +AL+ 
Sbjct: 30  PSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALID 89

Query: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH 169
            G  F+ R +F     V+ G  + F +  + WK  RR     +RNF       ++ +E  
Sbjct: 90  HGEEFSGRGSFPVAEKVNKGLGILFSN-GKRWKEIRRFCLMTLRNF----GMGKRSIEDR 144

Query: 170 VLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNE 229
           V  EAR LV  L + +A     DP  +   A  NV+ +V F  R+ + D  F  L+    
Sbjct: 145 VQEEARCLVEELRKTNASPC--DPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFN 202

Query: 230 EFGRTVGAGSLVDVMPWLQY---FPNPVRTVFREFEQLNRNFS---NFILDKFLRHCESL 283
           E  R + +       PW+Q    FP  +  +     ++  NF+   +++L++   H ESL
Sbjct: 203 ENLRILSS-------PWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESL 255

Query: 284 RPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLL 343
              +A RD +D F++  E+    + H   +   +E++ AT+TD+FGA  +T ST L++ L
Sbjct: 256 DMNSA-RDFIDCFLIKMEQ----EKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGL 310

Query: 344 LLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHAT 403
           LL  +YP+V  +VQ E++ VVGR+R PCM D+ ++PY  A ++E  R+   +P  +PHA 
Sbjct: 311 LLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAV 370

Query: 404 TANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIF 463
           T +     Y IPK T +  +  SV H+  ++PNPE FDP  FLDK G   K  +   M F
Sbjct: 371 TCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKK--SDYFMPF 428

Query: 464 SVGKRRCIGEELSKMQLFLFISILAHQCDFRA 495
           S GKR C+GE L++M+LFLF++ +    + ++
Sbjct: 429 SAGKRMCMGEGLARMELFLFLTTILQNFNLKS 460


>gi|7949031 cytochrome P450, family 2, subfamily B, polypeptide 6
           [Homo sapiens]
          Length = 491

 Score =  241 bits (615), Expect = 1e-63
 Identities = 162/492 (32%), Positives = 265/492 (53%), Gaps = 27/492 (5%)

Query: 20  QTTLLLLLSVLATVHVGQRLLRQRRRQLRSA-PPGPFAWPLIGNAAAVGQAAHL-SFARL 77
           + ++LL L++L  + +   LL QR        PPGP   PL+GN   + +   L SF R 
Sbjct: 2   ELSVLLFLALLTGLLL---LLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRF 58

Query: 78  ARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY 137
             +YGDVF + LG  P+V+L G  AI +ALV +  AF+ R   A       G  + F + 
Sbjct: 59  REKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFAN- 117

Query: 138 SEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLT 197
              WKV RR + + MR+F       ++ +E  +  EA+ L+  L +    GA +DP  L 
Sbjct: 118 GNRWKVLRRFSVTTMRDF----GMGKRSVEERIQEEAQCLIEELRKSK--GALMDPTFLF 171

Query: 198 VVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGA--GSLVDVMP-WLQYFPNPV 254
               AN++ ++ FG R+ + D EF ++L+   +    + +  G L ++   +L+YFP   
Sbjct: 172 QSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAH 231

Query: 255 RTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGAR 314
           R V++  +++N     +I     +H E+L P +AP+D++D ++L  EK+ + ++H   + 
Sbjct: 232 RQVYKNLQEINA----YIGHSVEKHRETLDP-SAPKDLIDTYLLHMEKEKS-NAH---SE 282

Query: 315 LDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGD 374
              +N+      +F A  +T ST L++  LL  +YP V  RV  E++QV+G  R P + D
Sbjct: 283 FSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHD 342

Query: 375 QPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKW 434
           +  +PY  A +YE  RFS  +P+ +PH  T +TS  GY IPKDT VF+   +  HDP  +
Sbjct: 343 RAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYF 402

Query: 435 PNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFR 494
             P+ F+P  FLD +G + K  T   + FS+GKR C+GE +++ +LFLF + +       
Sbjct: 403 EKPDAFNPDHFLDANGALKK--TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSM- 459

Query: 495 ANPNEPAKMNFS 506
           A+P  P  ++ +
Sbjct: 460 ASPVAPEDIDLT 471


>gi|13699818 cytochrome P450, family 2, subfamily C, polypeptide 9
           [Homo sapiens]
          Length = 490

 Score =  238 bits (607), Expect = 1e-62
 Identities = 147/449 (32%), Positives = 237/449 (52%), Gaps = 22/449 (4%)

Query: 51  PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109
           PPGP   P+IGN   +G +    S   L++ YG VF +  G  PIVVL+G  A+ +AL+ 
Sbjct: 30  PPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALID 89

Query: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH 169
            G  F+ R  F      + G  + F +  + WK  RR +   +RNF       ++ +E  
Sbjct: 90  LGEEFSGRGIFPLAERANRGFGIVFSN-GKKWKEIRRFSLMTLRNF----GMGKRSIEDR 144

Query: 170 VLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNE 229
           V  EAR LV  L +  A     DP  +   A  NV+ ++ F  R+ + D +F  L+    
Sbjct: 145 VQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLN 202

Query: 230 EFGRTVGAGSLV---DVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPG 286
           E  + + +  +    +  P + YFP     + +    +     ++IL+K   H ES+   
Sbjct: 203 ENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMK----SYILEKVKEHQESMDMN 258

Query: 287 AAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLF 346
             P+D +D F++  EK    + H   +   +E++  T  D+FGA  +T ST L++ LLL 
Sbjct: 259 N-PQDFIDCFLMKMEK----EKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLL 313

Query: 347 TRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTAN 406
            ++P+V  +VQ E+++V+GR+R PCM D+ ++PY  A ++E  R+   +P ++PHA T +
Sbjct: 314 LKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCD 373

Query: 407 TSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVG 466
                Y IPK T + ++  SV HD  ++PNPE FDP  FLD+ G   K  +   M FS G
Sbjct: 374 IKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKK--SKYFMPFSAG 431

Query: 467 KRRCIGEELSKMQLFLFISILAHQCDFRA 495
           KR C+GE L+ M+LFLF++ +    + ++
Sbjct: 432 KRICVGEALAGMELFLFLTSILQNFNLKS 460


>gi|4503219 cytochrome P450, family 2, subfamily C, polypeptide 19
           [Homo sapiens]
          Length = 490

 Score =  230 bits (587), Expect = 2e-60
 Identities = 148/452 (32%), Positives = 233/452 (51%), Gaps = 28/452 (6%)

Query: 51  PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109
           PPGP   P+IGN   +  +    S   L++ YG VF +  G   +VVL+G   + +AL+ 
Sbjct: 30  PPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALID 89

Query: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH 169
            G  F+ R  F      + G  + F +  + WK  RR +   +RNF       ++ +E  
Sbjct: 90  LGEEFSGRGHFPLAERANRGFGIVFSN-GKRWKEIRRFSLMTLRNF----GMGKRSIEDR 144

Query: 170 VLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNE 229
           V  EAR LV  L +  A     DP  +   A  NV+ ++ F  R+ + D +F  L+    
Sbjct: 145 VQEEARCLVEELRKTKASPC--DPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLN 202

Query: 230 EFGRTVGAGSLVDVMPWLQY---FPNPVRTVFREFEQLNRNFS---NFILDKFLRHCESL 283
           E  R V         PW+Q    FP  +        +L +N +   + IL+K   H ES+
Sbjct: 203 ENIRIVST-------PWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESM 255

Query: 284 RPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLL 343
                PRD +D F++  EK+         +   +EN+  T  D+ GA  +T ST L++ L
Sbjct: 256 DINN-PRDFIDCFLIKMEKEKQNQQ----SEFTIENLVITAADLLGAGTETTSTTLRYAL 310

Query: 344 LLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHAT 403
           LL  ++P+V  +VQ E+++V+GR+R PCM D+ ++PY  A ++E  R+   +P ++PHA 
Sbjct: 311 LLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAV 370

Query: 404 TANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIF 463
           T +     Y IPK T +  +  SV HD  ++PNPE FDP  FLD+ G   K  ++  M F
Sbjct: 371 TCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKK--SNYFMPF 428

Query: 464 SVGKRRCIGEELSKMQLFLFISILAHQCDFRA 495
           S GKR C+GE L++M+LFLF++ +    + ++
Sbjct: 429 SAGKRICVGEGLARMELFLFLTFILQNFNLKS 460


>gi|98991773 cytochrome P450, family 2, subfamily C, polypeptide 8
           [Homo sapiens]
          Length = 490

 Score =  229 bits (584), Expect = 5e-60
 Identities = 154/480 (32%), Positives = 244/480 (50%), Gaps = 33/480 (6%)

Query: 23  LLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARRY 81
           L+L LS +    + ++  R+R+      PPGP   P+IGN   +  +    SF   ++ Y
Sbjct: 7   LVLCLSFMLLFSLWRQSCRRRK-----LPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVY 61

Query: 82  GDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHW 141
           G VF +  G  PIVV +G  A+ +AL+  G  F+ R      + ++ G  +   +  + W
Sbjct: 62  GPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSN-GKRW 120

Query: 142 KVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAV 201
           K  RR + + +RNF       ++ +E  V  EA  LV  L +  A     DP  +   A 
Sbjct: 121 KEIRRFSLTTLRNF----GMGKRSIEDRVQEEAHCLVEELRKTKASPC--DPTFILGCAP 174

Query: 202 ANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQY---FPNPVRTVF 258
            NV+ +V F  R+ + D  F  L+    E  R + +       PW+Q    FP  +    
Sbjct: 175 CNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNS-------PWIQVCNNFPLLIDCFP 227

Query: 259 REFEQLNRNFS---NFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARL 315
               ++ +N +   ++I +K   H  SL     PRD +D F++  E++         +  
Sbjct: 228 GTHNKVLKNVALTRSYIREKVKEHQASLDVNN-PRDFIDCFLIKMEQEKDNQK----SEF 282

Query: 316 DLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQ 375
           ++EN+  T+ D+F A  +T ST L++ LLL  ++P+V  +VQ E+D V+GR R PCM D+
Sbjct: 283 NIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDR 342

Query: 376 PNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWP 435
            ++PY  A ++E  R+S  VP  +PHA T +T    Y IPK T +     SV HD  ++P
Sbjct: 343 SHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFP 402

Query: 436 NPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRA 495
           NP  FDP  FLDK+G   K  +   M FS GKR C GE L++M+LFLF++ +    + ++
Sbjct: 403 NPNIFDPGHFLDKNGNFKK--SDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKS 460


>gi|13699809 cytochrome P450, family 2, subfamily A, polypeptide 13
           [Homo sapiens]
          Length = 494

 Score =  225 bits (573), Expect = 9e-59
 Identities = 161/506 (31%), Positives = 269/506 (53%), Gaps = 31/506 (6%)

Query: 24  LLLLSVLA--TVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARR 80
           LLL+++LA  TV V   + RQR+ + +  PPGP   P IGN   +  +  + S  +++ R
Sbjct: 6   LLLVTLLACLTVMVLMSVWRQRKSRGK-LPPGPTPLPFIGNYLQLNTEQMYNSLMKISER 64

Query: 81  YGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH 140
           YG VF I LG   +VVL G  A+ +ALV Q   F+ R   A+F  +  G  +AF +  E 
Sbjct: 65  YGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSN-GER 123

Query: 141 WKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVA 200
            K  RR + + +R F       ++ +E  +  EA  L+  L RG+  GA +DP       
Sbjct: 124 AKQLRRFSIATLRGFGV----GKRGIEERIQEEAGFLIDAL-RGT-HGANIDPTFFLSRT 177

Query: 201 VANVMSAVCFGCRYSHDDPEFRELLSH---NEEFGRTVGAGSLVDVMPW-LQYFPNPVRT 256
           V+NV+S++ FG R+ ++D EF  LL     + +F  T   G L ++    +++ P P + 
Sbjct: 178 VSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTAT-STGQLYEMFSSVMKHLPGPQQQ 236

Query: 257 VFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLD 316
            F+E + L     +FI  K   +  +L P + PRD +D+F++  +++    +        
Sbjct: 237 AFKELQGLE----DFIAKKVEHNQRTLDPNS-PRDFIDSFLIRMQEEEKNPN----TEFY 287

Query: 317 LENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQP 376
           L+N+  T  ++F A  +T+ST L++  LL  ++P+V+ +V  E+D+V+G++R P   D+ 
Sbjct: 288 LKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRA 347

Query: 377 NLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPN 436
            +PY  A ++E  RF   +P+ + H    +T    + +PK T VF    SV  DP  + N
Sbjct: 348 KMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSN 407

Query: 437 PENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRAN 496
           P +F+P  FLDK G   K  +   + FS+GKR C GE L++M+LFLF + +     F+ +
Sbjct: 408 PRDFNPQHFLDKKGQFKK--SDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFK-S 464

Query: 497 PNEPAKMNFS---YGLTIKPKSFKVN 519
           P  P  ++ S    G    P+++ ++
Sbjct: 465 PQSPKDIDVSPKHVGFATIPRNYTMS 490


>gi|19743565 cytochrome P450, family 2, subfamily F, polypeptide 1
           [Homo sapiens]
          Length = 491

 Score =  224 bits (572), Expect = 1e-58
 Identities = 156/509 (30%), Positives = 260/509 (51%), Gaps = 32/509 (6%)

Query: 17  SIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAV-GQAAHLSFA 75
           SI    LLLLL+++        LL    R     PPGP    ++GN   +  Q    S  
Sbjct: 3   SISTAILLLLLALVCL------LLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLT 56

Query: 76  RLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFG 135
           +L++ YG ++ + LG   +VVL+G +A+ +ALV QG  F+ R  + +F   + G  +AF 
Sbjct: 57  KLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFS 116

Query: 136 HYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRP 195
              + WKV R+ +  ++RNF       ++ +E  +L E   L+A L +   +G   DP  
Sbjct: 117 S-GDRWKVLRQFSIQILRNF----GMGKRSIEERILEEGSFLLAELRK--TEGEPFDPTF 169

Query: 196 LTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGA--GSLVDVMP-WLQYFPN 252
           +   +V+N++ +V FG R+ +DD     ++    +  + + +  G L D+ P  L + P 
Sbjct: 170 VLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPG 229

Query: 253 PVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILS-AEKKAAGDSHGG 311
           P + +F+ F+ L    ++ + D    H  SL P  +PRD +  F+   AE+K    SH  
Sbjct: 230 PHQRIFQNFKCLRDLIAHSVHD----HQASLDP-RSPRDFIQCFLTKMAEEKEDPLSH-- 282

Query: 312 GARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPC 371
                ++ +  T  ++      T+ST L    L   +YP VQ RVQ E+D VVGR RLP 
Sbjct: 283 ---FHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPA 339

Query: 372 MGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDP 431
           + D+  +PY  A ++E  RF+  +P+ +PH  T +T+  G+ IPK T V     +V++DP
Sbjct: 340 LKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDP 399

Query: 432 LKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQC 491
            ++  P+ F+P  FLD +    K  +   M FS G+R C+GE L++M+LFL+++ +    
Sbjct: 400 SQFLTPQEFNPEHFLDANQSFKK--SPAFMPFSAGRRLCLGESLARMELFLYLTAILQSF 457

Query: 492 DFR--ANPNEPAKMNFSYGLTIKPKSFKV 518
             +    P +      S GL   P+ F++
Sbjct: 458 SLQPLGAPEDIDLTPLSSGLGNLPRPFQL 486


>gi|45267826 cytochrome P450, family 2, subfamily R, polypeptide 1
           [Homo sapiens]
          Length = 501

 Score =  220 bits (561), Expect = 2e-57
 Identities = 151/504 (29%), Positives = 244/504 (48%), Gaps = 33/504 (6%)

Query: 23  LLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNA---AAVGQAAHLSFARLAR 79
           L LLL  L      ++LL+QRR      PPGP   P IGN    AA  +  H+   + ++
Sbjct: 18  LFLLLFALGV----RQLLKQRRPM--GFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQ 71

Query: 80  RYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSE 139
            YG++F + LG    VVLNG   + + LV Q   FADRP    F  ++    +    Y  
Sbjct: 72  VYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGR 131

Query: 140 HWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVV 199
            W   RR A +  R F   Q    +  E  +L E +     +   +  G   D + L   
Sbjct: 132 GWVDHRRLAVNSFRYFGYGQ----KSFESKILEETKFFNDAIE--TYKGRPFDFKQLITN 185

Query: 200 AVANVMSAVCFGCRYSHDDPEFR---ELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRT 256
           AV+N+ + + FG R++++D +F+   EL S N E   +     L +  PW+   P     
Sbjct: 186 AVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASV-FLYNAFPWIGILP----- 239

Query: 257 VFREFEQLNRNFSNF--ILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGAR 314
            F + +QL RN +     L + +      R    P+  +DA++   ++     S    + 
Sbjct: 240 -FGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPS----ST 294

Query: 315 LDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGD 374
              EN+  ++ ++  A  +T +  L+W +L    YP++Q +VQ E+D ++G +  P   D
Sbjct: 295 FSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDD 354

Query: 375 QPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKW 434
           +  +PY  A L+E +RF + VP+ I HAT+ +  V GY IPK T V  N +SV+ D   W
Sbjct: 355 KCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYW 414

Query: 435 PNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFR 494
            +PE F P RFLD  G   K     ++ FS+G+R C+GE L++M++FLF + L  +    
Sbjct: 415 RDPEVFHPERFLDSSGYFAK--KEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLH 472

Query: 495 ANPNEPAKMNFSYGLTIKPKSFKV 518
                   +    G+T++P+ + +
Sbjct: 473 FPHELVPDLKPRLGMTLQPQPYLI 496


>gi|68509921 cytochrome P450, family 2, subfamily D, polypeptide 6
           isoform 2 [Homo sapiens]
          Length = 446

 Score =  214 bits (545), Expect = 2e-55
 Identities = 158/492 (32%), Positives = 222/492 (45%), Gaps = 79/492 (16%)

Query: 13  LNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAH 71
           L PL++     LLL+           L+ +R+R     PPGP   P +GN   V  Q   
Sbjct: 6   LVPLAVIVAIFLLLVD----------LMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTP 55

Query: 72  LSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRS 131
             F +L RR+GDVF ++L   P+VVLNG  A+ +ALV  G   ADRP     +++  G  
Sbjct: 56  YCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFG-- 113

Query: 132 MAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFL 191
                                       PRS+                        G   
Sbjct: 114 ----------------------------PRSQ------------------------GRPF 121

Query: 192 DPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVM---PWLQ 248
            P  L   AV+NV++++  G R+ +DDP F  LL   +E G    +G L +V+   P L 
Sbjct: 122 RPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQE-GLKEESGFLREVLNAVPVLL 180

Query: 249 YFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDS 308
           + P     V R      + F   + +    H  +  P   PRD+ +AF+   EK A G+ 
Sbjct: 181 HIPALAGKVLR----FQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEK-AKGNP 235

Query: 309 HGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDR 368
                  + EN+   + D+F A   T ST L W LLL   +PDVQ RVQ E+D V+G+ R
Sbjct: 236 ESS---FNDENLCIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVR 292

Query: 369 LPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVN 428
            P MGDQ ++PY  A ++E  RF   VP+ + H T+ +  V G+ IPK T +  N  SV 
Sbjct: 293 RPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVL 352

Query: 429 HDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILA 488
            D   W  P  F P  FLD  G   K      + FS G+R C+GE L++M+LFLF + L 
Sbjct: 353 KDEAVWEKPFRFHPEHFLDAQGHFVK--PEAFLPFSAGRRACLGEPLARMELFLFFTSLL 410

Query: 489 HQCDFRANPNEP 500
               F     +P
Sbjct: 411 QHFSFSVPTGQP 422


>gi|189339233 cytochrome P450, family 2, subfamily A, polypeptide 6
           [Homo sapiens]
          Length = 494

 Score =  211 bits (537), Expect = 1e-54
 Identities = 149/484 (30%), Positives = 254/484 (52%), Gaps = 25/484 (5%)

Query: 23  LLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARRY 81
           LL+ L V  TV V   + +QR+ + +  PPGP   P IGN   +  +  + S  +++ RY
Sbjct: 7   LLVALLVCLTVMVLMSVWQQRKSKGK-LPPGPTPLPFIGNYLQLNTEQMYNSLMKISERY 65

Query: 82  GDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHW 141
           G VF I LG   +VVL G  A+ +ALV Q   F+ R   A+F  V  G  + F +  E  
Sbjct: 66  GPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSN-GERA 124

Query: 142 KVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAV 201
           K  RR + + +R+F       ++ +E  +  EA  L+  L RG+  GA +DP       V
Sbjct: 125 KQLRRFSIATLRDFGV----GKRGIEERIQEEAGFLIDAL-RGTG-GANIDPTFFLSRTV 178

Query: 202 ANVMSAVCFGCRYSHDDPEFRELLSHNEEFGR--TVGAGSLVDVMPW-LQYFPNPVRTVF 258
           +NV+S++ FG R+ + D EF  LL       +  +   G L ++    +++ P P +  F
Sbjct: 179 SNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF 238

Query: 259 REFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLE 318
               QL +   +FI  K   +  +L P + PRD +D+F++  +++    +        L+
Sbjct: 239 ----QLLQGLEDFIAKKVEHNQRTLDPNS-PRDFIDSFLIRMQEEEKNPN----TEFYLK 289

Query: 319 NVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNL 378
           N+  T  ++F    +T+ST L++  LL  ++P+V+ +V  E+D+V+G++R P   D+  +
Sbjct: 290 NLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKM 349

Query: 379 PYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPE 438
           PY+ A ++E  RF   +P+++      +T    + +PK T V+    SV  DP  + NP+
Sbjct: 350 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQ 409

Query: 439 NFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPN 498
           +F+P  FL++ G   K  +   + FS+GKR C GE L++M+LFLF + +    +FR   +
Sbjct: 410 DFNPQHFLNEKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ--NFRLKSS 465

Query: 499 EPAK 502
           +  K
Sbjct: 466 QSPK 469


>gi|10834998 cytochrome P450, family 2, subfamily E, polypeptide 1
           [Homo sapiens]
          Length = 493

 Score =  210 bits (535), Expect = 2e-54
 Identities = 153/482 (31%), Positives = 243/482 (50%), Gaps = 57/482 (11%)

Query: 24  LLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVG-QAAHLSFARLARRYG 82
           LLL+S+   VH    L           PPGPF  P+IGN   +  +    SF RLA+R+G
Sbjct: 17  LLLVSMWRQVHSSWNL-----------PPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFG 65

Query: 83  DVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADR---PAFASFRVVSGGRSMAFGHYSE 139
            VF + +GS  +VV++G +A+ +AL+     F+ R   PAF + R     R + F +   
Sbjct: 66  PVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHR----DRGIIFNN-GP 120

Query: 140 HWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVV 199
            WK  RR + + +RN+       +Q  E  +  EA  L+  L +    G   DP  L   
Sbjct: 121 TWKDIRRFSLTTLRNY----GMGKQGNESRIQREAHFLLEALRK--TQGQPFDPTFLIGC 174

Query: 200 AVANVMSAVCFGCRYSHDDPEFRELLS-HNEEFGRTVGAGSLVDVMPWLQ---------- 248
           A  NV++ + F   + ++D +F  L+   NE F        L+   PWLQ          
Sbjct: 175 APCNVIADILFRKHFDYNDEKFLRLMYLFNENF-------HLLST-PWLQLYNNFPSFLH 226

Query: 249 YFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDS 308
           Y P   R V +   ++      ++ ++   H +SL P   PRD+ D  ++  EK    + 
Sbjct: 227 YLPGSHRKVIKNVAEVKE----YVSERVKEHHQSLDPNC-PRDLTDCLLVEMEK----EK 277

Query: 309 HGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDR 368
           H       ++ +  T+ D+F A  +T ST L++ LL+  +YP+++ ++  E+D+V+G  R
Sbjct: 278 HSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSR 337

Query: 369 LPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVN 428
           +P + D+  +PY+ A ++E  RF + VP  +PH  T +T   GY IPK TVV     SV 
Sbjct: 338 IPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVL 397

Query: 429 HDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFI-SIL 487
           +D  ++P+PE F P  FL+++G      +     FS GKR C GE L++M+LFL + +IL
Sbjct: 398 YDNQEFPDPEKFKPEHFLNENGKFK--YSDYFKPFSTGKRVCAGEGLARMELFLLLCAIL 455

Query: 488 AH 489
            H
Sbjct: 456 QH 457


>gi|13449277 cytochrome P450, family 2, subfamily S, polypeptide 1
           [Homo sapiens]
          Length = 504

 Score =  208 bits (530), Expect = 9e-54
 Identities = 150/470 (31%), Positives = 234/470 (49%), Gaps = 26/470 (5%)

Query: 23  LLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLS-FARLARRY 81
           LLL L++L  + +     R R       PPGP   PL+GN   +   A  S   RL+++Y
Sbjct: 9   LLLALALLLLLTLALSGTRARGH----LPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKY 64

Query: 82  GDVFQIRLGSC-PIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH 140
           G VF I LG   P+VVL G+ A+ +AL  Q   F+ R   A       G  + F +  E 
Sbjct: 65  GPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSN-GER 123

Query: 141 WKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVA 200
           W+  R+     +R+    +    ++++    +EAR LV        +G   DP  L   A
Sbjct: 124 WRQLRKFTMLALRDLGMGKREGEELIQ----AEARCLVETFQ--GTEGRPFDPSLLLAQA 177

Query: 201 VANVMSAVCFGCRYSHDDPEFRELL--SHNEEFGRTVGAGSLVDVMPW-LQYFPNPVRTV 257
            +NV+ ++ FG R+S++D EF+ ++  +     G +   G   ++  W L+  P P + +
Sbjct: 178 TSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQL 237

Query: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317
                 L    + F + +  +H  +L      RD++DAF+L    K A +    G     
Sbjct: 238 LHHVSTL----AAFTVRQVQQHQGNLDASGPARDLVDAFLL----KMAQEEQNPGTEFTN 289

Query: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377
           +N+  T+  +  A   T+ST + + LLL  +YP VQ  V+ EL++ +G  + P +GD+  
Sbjct: 290 KNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTR 349

Query: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNP 437
           LPY  A L+EA R  + VP+ IP      T   GY +P+ T VF    S+ HDP  + +P
Sbjct: 350 LPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHP 409

Query: 438 ENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISIL 487
           E F+P RFLD DG   K      + FS+GKR C+GE L+K +LFLF + +
Sbjct: 410 EEFNPDRFLDADGRFRKH--EAFLPFSLGKRVCLGEGLAKAELFLFFTTI 457


>gi|15147330 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 1 [Homo sapiens]
          Length = 494

 Score =  207 bits (526), Expect = 3e-53
 Identities = 147/485 (30%), Positives = 253/485 (52%), Gaps = 27/485 (5%)

Query: 24  LLLLSVLATVHVGQRL-LRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHL--SFARLARR 80
           LLL+++LA + V   + + Q+R+     PPGP   P IGN   +    H+  S  + +  
Sbjct: 6   LLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLN-TEHICDSIMKFSEC 64

Query: 81  YGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEH 140
           YG VF I LG   +VVL G  A+ +ALV Q   F+ R   A+F  V  G  +AF +  E 
Sbjct: 65  YGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSN-GER 123

Query: 141 WKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVA 200
            K   R A + +R+F       ++ +E  +  E+  L+  +   S  GA +DP       
Sbjct: 124 AKQLLRFAIATLRDFGV----GKRGIEERIQEESGFLIEAI--RSTHGANIDPTFFLSRT 177

Query: 201 VANVMSAVCFGCRYSHDDPEFRELLSHNEEFGR--TVGAGSLVDVMPW-LQYFPNPVRTV 257
           V+NV+S++ FG R+ ++D EF  LLS      +  +   G L ++    +++ P P +  
Sbjct: 178 VSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQA 237

Query: 258 FREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDL 317
           F+    L +   +FI  K   +  +L P + P+D +D+F++  +++    +        L
Sbjct: 238 FK----LLQGLEDFIAKKVEHNQRTLDPNS-PQDFIDSFLIHMQEEEKNPN----TEFYL 288

Query: 318 ENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPN 377
           +N+  +  ++F A  +T+ST L++  LL  ++P+V+ +V  E+D+V+G++R P   D+  
Sbjct: 289 KNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTK 348

Query: 378 LPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNP 437
           +PY+ A ++E  RF   +P+++      +T    + +PK T VF    SV  DP  + NP
Sbjct: 349 MPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNP 408

Query: 438 ENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANP 497
           ++F+P  FLD  G   K  +   + FS+GKR C GE L++M+LFLF + +    +FR   
Sbjct: 409 QDFNPQHFLDDKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ--NFRLKS 464

Query: 498 NEPAK 502
           ++  K
Sbjct: 465 SQSPK 469


>gi|4503195 cytochrome P450, family 17 [Homo sapiens]
          Length = 508

 Score =  206 bits (525), Expect = 3e-53
 Identities = 132/484 (27%), Positives = 234/484 (48%), Gaps = 22/484 (4%)

Query: 51  PPGPFAWPLIGNAAAVGQAAHL--SFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALV 108
           P    + PL+G+   + +  H+  +F +L ++YG ++ +R+G+   V++   +   + L+
Sbjct: 28  PKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLI 87

Query: 109 QQGSAFADRPAFASFRVVSGGRS-MAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLE 167
           ++G  F+ RP  A+  + S  R  +AF     HW++ RR A +    F        Q LE
Sbjct: 88  KKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALF----KDGDQKLE 143

Query: 168 GHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSH 227
             +  E   L  +L   + +G  +D      VAV NV+S +CF   Y + DPE   + ++
Sbjct: 144 KIICQEISTLCDMLA--THNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNY 201

Query: 228 NEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGA 287
           NE     +   SLVD++PWL+ FPN      +   ++  +  N IL+ +     S     
Sbjct: 202 NEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRS----D 257

Query: 288 APRDMMDAFILSAEKKAAGDSHGGGARLDLE-----NVPATITDIFGASQDTLSTALQWL 342
           +  +M+D  +   + K   D+   G   D E     ++  TI DIFGA  +T ++ ++W 
Sbjct: 258 SITNMLDTLM---QAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWT 314

Query: 343 LLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHA 402
           L      P V+ ++  E+DQ VG  R P + D+  L  + A + E +R     P+ IPH 
Sbjct: 315 LAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHK 374

Query: 403 TTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMI 462
              ++S+  + + K T V +N W+++H+  +W  P+ F P RFL+  G      +   + 
Sbjct: 375 ANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLP 434

Query: 463 FSVGKRRCIGEELSKMQLFLFISILAHQCDFRA-NPNEPAKMNFSYGLTIKPKSFKVNVT 521
           F  G R CIGE L++ +LFL ++ L  + D    +  +   +     +     SFKV + 
Sbjct: 435 FGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIK 494

Query: 522 LRES 525
           +R++
Sbjct: 495 VRQA 498


>gi|64368472 cytochrome P450, family 2, subfamily W, polypeptide 1
           [Homo sapiens]
          Length = 490

 Score =  202 bits (514), Expect = 6e-52
 Identities = 158/478 (33%), Positives = 231/478 (48%), Gaps = 41/478 (8%)

Query: 51  PPGPFAWPLIGNAAAVGQAAH-LSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109
           PPGP   PL+GN   +  +    S   L+ RYG VF + LG    VVL G  A+ +AL  
Sbjct: 32  PPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAG 91

Query: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQR----RAAHSMMRNFFTRQPRSRQV 165
            G   ADRP  A F+++  G  + F      W+  R    RA HS+      R+P + ++
Sbjct: 92  PGQELADRPPIAIFQLIQRGGGIFFSS-GARWRAARQFTVRALHSLGVG---REPVADKI 147

Query: 166 LEGHVLSEARELVALLVRGSADGAFLDPRPLTVV--AVANVMSAVCFGCRYSHDDPEFRE 223
           L+        EL  L   G  DG    P PL ++  A +N+  A+ FG R+ + DP F  
Sbjct: 148 LQ--------ELKCL--SGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVS 197

Query: 224 LLSHNEEFGRTVGAGSL--VDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCE 281
           LL   +E    +G+  L   +V PWL       R V R+ E++       +        E
Sbjct: 198 LLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLL--------E 249

Query: 282 SLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLE-NVPATITDIFGASQDTLSTALQ 340
           + RP   P D + +++ +  ++  GD   G   L  E N  A   D+  A  +T S  LQ
Sbjct: 250 ARRPHVCPGDPVCSYVDALIQQGQGDDPEG---LFAEANAVACTLDMVMAGTETTSATLQ 306

Query: 341 WLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIP 400
           W  LL  R+PDVQ RVQ ELD+V+G  R P + DQ  LPY  A L+E  RF + +P  +P
Sbjct: 307 WAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLP-HVP 365

Query: 401 HATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRV 460
             T A+T + G+ +PK T V     SV  D  +W  P  F+P  FLD +G   K      
Sbjct: 366 RCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVK--REAF 423

Query: 461 MIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPN-EPAKMNF--SYGLTIKPKS 515
           + FS G+R C+GE L++ +LFL  + L  +      P   PA ++   +   T++P++
Sbjct: 424 LPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRA 481


>gi|193083148 cytochrome P450 family 2 subfamily C polypeptide 18
           isoform 2 [Homo sapiens]
          Length = 431

 Score =  199 bits (505), Expect = 7e-51
 Identities = 140/446 (31%), Positives = 215/446 (48%), Gaps = 75/446 (16%)

Query: 51  PPGPFAWPLIGNAAAVG-QAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQ 109
           P GP   P+IGN   +  +    S    ++ YG VF +  G  PIVVL+G  A+ +AL+ 
Sbjct: 30  PSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALID 89

Query: 110 QGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGH 169
            G  F+ R +F     V+ G  + F +  + WK  RR     +RNF       ++ +E  
Sbjct: 90  HGEEFSGRGSFPVAEKVNKGLGILFSN-GKRWKEIRRFCLMTLRNF----GMGKRSIEDR 144

Query: 170 VLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNE 229
           V  EAR LV  L + +A     DP  +   A  NV+ +V F     HD            
Sbjct: 145 VQEEARCLVEELRKTNASPC--DPTFILGCAPCNVICSVIF-----HD------------ 185

Query: 230 EFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAP 289
                                          F+  ++ F N +++KF    E+LR  ++P
Sbjct: 186 ------------------------------RFDYKDQRFLN-LMEKFN---ENLRILSSP 211

Query: 290 RDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRY 349
                            + H   +   +E++ AT+TD+FGA  +T ST L++ LLL  +Y
Sbjct: 212 WIQ--------------EKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKY 257

Query: 350 PDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSV 409
           P+V  +VQ E++ VVGR+R PCM D+ ++PY  A ++E  R+   +P  +PHA T +   
Sbjct: 258 PEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKF 317

Query: 410 LGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRR 469
             Y IPK T +  +  SV H+  ++PNPE FDP  FLDK G   K  +   M FS GKR 
Sbjct: 318 KNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKK--SDYFMPFSAGKRM 375

Query: 470 CIGEELSKMQLFLFISILAHQCDFRA 495
           C+GE L++M+LFLF++ +    + ++
Sbjct: 376 CMGEGLARMELFLFLTTILQNFNLKS 401


>gi|15147328 cytochrome P450, family 2, subfamily A, polypeptide 7
           isoform 2 [Homo sapiens]
          Length = 443

 Score =  160 bits (405), Expect = 3e-39
 Identities = 129/484 (26%), Positives = 228/484 (47%), Gaps = 76/484 (15%)

Query: 24  LLLLSVLATVHVGQRL-LRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYG 82
           LLL+++LA + V   + + Q+R+     PPGP   P IGN                    
Sbjct: 6   LLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGN-------------------- 45

Query: 83  DVFQIRLGSCPIVVLNGERAIHQAL-VQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHW 141
                       + LN E      + V QG AF++                      E  
Sbjct: 46  -----------YLQLNTEHICDSIMKVSQGVAFSN---------------------GERA 73

Query: 142 KVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAV 201
           K   R A + +R+F       ++ +E  +  E+  L+  +   S  GA +DP       V
Sbjct: 74  KQLLRFAIATLRDFGV----GKRGIEERIQEESGFLIEAI--RSTHGANIDPTFFLSRTV 127

Query: 202 ANVMSAVCFGCRYSHDDPEFRELLSHNEEFGR--TVGAGSLVDVMPW-LQYFPNPVRTVF 258
           +NV+S++ FG R+ ++D EF  LLS      +  +   G L ++    +++ P P +  F
Sbjct: 128 SNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAF 187

Query: 259 REFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLE 318
           +    L +   +FI  K   +  +L P + P+D +D+F++  +++    +        L+
Sbjct: 188 K----LLQGLEDFIAKKVEHNQRTLDPNS-PQDFIDSFLIHMQEEEKNPN----TEFYLK 238

Query: 319 NVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNL 378
           N+  +  ++F A  +T+ST L++  LL  ++P+V+ +V  E+D+V+G++R P   D+  +
Sbjct: 239 NLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKM 298

Query: 379 PYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPE 438
           PY+ A ++E  RF   +P+++      +T    + +PK T VF    SV  DP  + NP+
Sbjct: 299 PYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQ 358

Query: 439 NFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPN 498
           +F+P  FLD  G   K  +   + FS+GKR C GE L++M+LFLF + +    +FR   +
Sbjct: 359 DFNPQHFLDDKGQFKK--SDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQ--NFRLKSS 414

Query: 499 EPAK 502
           +  K
Sbjct: 415 QSPK 418


>gi|14550409 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform a [Homo sapiens]
          Length = 495

 Score =  151 bits (382), Expect = 1e-36
 Identities = 137/484 (28%), Positives = 228/484 (47%), Gaps = 62/484 (12%)

Query: 23  LLLLLSVLATVHVGQRLLRQ--RRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARR 80
           LLLLL +LA    G RLL    + R L   P  P      G    +     +    L ++
Sbjct: 6   LLLLLPLLA----GARLLWNWWKLRSLHLPPLAP------GFLHLLQPDLPIYLLGLTQK 55

Query: 81  YGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGR-SMAFGHYSE 139
           +G ++++ LG   +VVLN +R I +A+V++ + FA RP   ++++VS     ++ G YS 
Sbjct: 56  FGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSRNYPDLSLGDYSL 115

Query: 140 HWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVV 199
            WK  ++   S +             L G +      +V  L +   +   +  +P T V
Sbjct: 116 LWKAHKKLTRSAL-------------LLG-IRDSMEPVVEQLTQEFCER--MRAQPGTPV 159

Query: 200 AVAN-----VMSAVC---FGCRYSHDD--PEFRELLSHNEEFGRTVGAGSL--VDVMPWL 247
           A+         S +C   FG +   D+  P + + +   +E  +T    S+  VDV+P+L
Sbjct: 160 AIEEEFSLLTCSIICYLTFGDKIKDDNLMPAYYKCI---QEVLKTWSHWSIQIVDVIPFL 216

Query: 248 QYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGD 307
           ++FPNP     R  +Q      + +  +  +H ESL  G   RDMMD  +    + +  +
Sbjct: 217 RFFPNPG---LRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQGVAQPSMEE 272

Query: 308 SHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVG-- 365
             G G  L+     A +  + G ++ T +T L W ++    +P++Q R+Q ELD  +G  
Sbjct: 273 --GSGQLLEGHVHMAAVDLLIGGTETTANT-LSWAVVFLLHHPEIQQRLQEELDHELGPG 329

Query: 366 --RDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVN 423
               R+P   D+  LP + A + E +R    VP+ +PH TT  +S+ GY IP+ TV+  N
Sbjct: 330 ASSSRVPYK-DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIPEGTVIIPN 388

Query: 424 QWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLF 483
               + D   W  P  F P RFL+          SR + F  G R C+GE L++++LF+ 
Sbjct: 389 LQGAHLDETVWERPHEFWPDRFLE------PGKNSRALAFGCGARVCLGEPLARLELFVV 442

Query: 484 ISIL 487
           ++ L
Sbjct: 443 LTRL 446


>gi|190570174 cytochrome P450, family 21, subfamily A, polypeptide 2
           isoform b [Homo sapiens]
          Length = 465

 Score =  122 bits (306), Expect = 8e-28
 Identities = 80/252 (31%), Positives = 129/252 (51%), Gaps = 18/252 (7%)

Query: 240 LVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILS 299
           +VDV+P+L++FPNP     R  +Q      + +  +  +H ESL  G   RDMMD  +  
Sbjct: 179 IVDVIPFLRFFPNPG---LRRLKQAIEKRDHIVEMQLRQHKESLVAGQW-RDMMDYMLQG 234

Query: 300 AEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAE 359
             + +  +  G G  L+     A +  + G ++ T +T L W ++    +P++Q R+Q E
Sbjct: 235 VAQPSMEE--GSGQLLEGHVHMAAVDLLIGGTETTANT-LSWAVVFLLHHPEIQQRLQEE 291

Query: 360 LDQVVG----RDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIP 415
           LD  +G      R+P   D+  LP + A + E +R    VP+ +PH TT  +S+ GY IP
Sbjct: 292 LDHELGPGASSSRVPYK-DRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISGYDIP 350

Query: 416 KDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEEL 475
           + TV+  N    + D   W  P  F P RFL+          SR + F  G R C+GE L
Sbjct: 351 EGTVIIPNLQGAHLDETVWERPHEFWPDRFLE------PGKNSRALAFGCGARVCLGEPL 404

Query: 476 SKMQLFLFISIL 487
           ++++LF+ ++ L
Sbjct: 405 ARLELFVVLTRL 416


>gi|55770850 cytochrome P450 family 24 subfamily A polypeptide 1
           isoform 1 precursor [Homo sapiens]
          Length = 514

 Score = 99.4 bits (246), Expect = 8e-21
 Identities = 62/191 (32%), Positives = 102/191 (53%), Gaps = 6/191 (3%)

Query: 314 RLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMG 373
           RL  + + A +T++  A+ +T + +L W+L   +R P VQ ++  E+  V+  +++P   
Sbjct: 310 RLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAE 369

Query: 374 DQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLG-YHIPKDTVVFVNQWSVNHDPL 432
           D  N+PY+ A L E+MR +  VP T    T    +VLG Y +PK TV+ +N   +     
Sbjct: 370 DLRNMPYLKACLKESMRLTPSVPFTT--RTLDKATVLGEYALPKGTVLMLNTQVLGSSED 427

Query: 433 KWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCD 492
            + +   F P R+L +   IN       + F VGKR CIG  L+++QL L +  +  + D
Sbjct: 428 NFEDSSQFRPERWLQEKEKIN---PFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYD 484

Query: 493 FRANPNEPAKM 503
            +A  NEP +M
Sbjct: 485 IQATDNEPVEM 495



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 30/110 (27%), Positives = 51/110 (46%), Gaps = 9/110 (8%)

Query: 46  QLRSAPPGPFAWPLIGNAAAV-----GQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGE 100
           Q  +A PGP +WPL+G+   +      +  H +     ++YG +F+++LGS   V L G 
Sbjct: 53  QNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHL-GS 111

Query: 101 RAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHY---SEHWKVQRRA 147
             + +AL +  SA+  R     ++     R   +G      E W+  R A
Sbjct: 112 PCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSA 161


>gi|4503231 cytochrome P450, family 3, subfamily A, polypeptide 5
           [Homo sapiens]
          Length = 502

 Score = 92.4 bits (228), Expect = 9e-19
 Identities = 114/489 (23%), Positives = 202/489 (41%), Gaps = 47/489 (9%)

Query: 20  QTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLAR 79
           +T LLL +S++     G R     +R      PGP   PL+GN  +  Q          +
Sbjct: 10  ETWLLLAVSLVLLYLYGTRTHGLFKRL---GIPGPTPLPLLGNVLSYRQGLWKFDTECYK 66

Query: 80  RYGDVFQIRLGSCPIVVLNGERAIHQALVQQG-SAFADRPAFASFRVVSGGRSMAFGHYS 138
           +YG ++    G  P++ +     I   LV++  S F +R +      +    S+A     
Sbjct: 67  KYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISLA---ED 123

Query: 139 EHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTV 198
           E WK  R    S++   FT            ++++  +++   +R  A+      +P+T+
Sbjct: 124 EEWKRIR----SLLSPTFTSGKLKEMF---PIIAQYGDVLVRNLRREAEKG----KPVTL 172

Query: 199 VAV-----ANVMSAVCFGCRY-SHDDPE--FRELLSHNEEFGRTVGAGSLVDVMPWLQYF 250
             +      +V++   FG    S ++P+  F E      +FG        + + P+L   
Sbjct: 173 KDIFGAYSMDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFL--- 229

Query: 251 PNPVRTVFREFEQLN-----RNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAA 305
             PV      FE LN     ++  NF L K +   +  R     +  +D   L  + + +
Sbjct: 230 -TPV------FEALNVSLFPKDTINF-LSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNS 281

Query: 306 GDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVG 365
            ++    A  DLE    +I  IF A  +T S+ L + L     +PDVQ ++Q E+D V+ 
Sbjct: 282 KETESHKALSDLELAAQSIIFIF-AGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLP 340

Query: 366 RDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQW 425
               P       + Y+   + E +R    V + +      +  + G  IPK ++V +  +
Sbjct: 341 NKAPPTYDAVVQMEYLDMVVNETLRLFP-VAIRLERTCKKDVEINGVFIPKGSMVVIPTY 399

Query: 426 SVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFIS 485
           +++HDP  W  PE F P RF  K   I+  + +    F  G R CIG   + M + L + 
Sbjct: 400 ALHHDPKYWTEPEEFRPERFSKKKDSIDPYIYTP---FGTGPRNCIGMRFALMNMKLALI 456

Query: 486 ILAHQCDFR 494
            +     F+
Sbjct: 457 RVLQNFSFK 465


>gi|13435386 cytochrome P450, family 3, subfamily A, polypeptide 4
           [Homo sapiens]
          Length = 503

 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 109/474 (22%), Positives = 194/474 (40%), Gaps = 37/474 (7%)

Query: 52  PGPFAWPLIGNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQG 111
           PGP   P +GN  +  +   +      ++YG V+    G  P++ +     I   LV++ 
Sbjct: 39  PGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKEC 98

Query: 112 -SAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHV 170
            S F +R  F     +    S+A     E WK  R    S++   FT       V    +
Sbjct: 99  YSVFTNRRPFGPVGFMKSAISIA---EDEEWKRLR----SLLSPTFTSGKLKEMV---PI 148

Query: 171 LSEARELVALLVRGSADGAFLDPRPLTVVAV-----ANVMSAVCFGCRY-SHDDPE--FR 222
           +++  +++   +R  A+      +P+T+  V      +V+++  FG    S ++P+  F 
Sbjct: 149 IAQYGDVLVRNLRREAETG----KPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFV 204

Query: 223 ELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCES 282
           E       F         + V P+L     P+  V        R  +NF L K ++  + 
Sbjct: 205 ENTKKLLRFDFLDPFFLSITVFPFLI----PILEVLN-ICVFPREVTNF-LRKSVKRMKE 258

Query: 283 LRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWL 342
            R     +  +D   L  + + + ++    A  DLE V  +I  IF A  +T S+ L ++
Sbjct: 259 SRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIF-AGYETTSSVLSFI 317

Query: 343 LLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHA 402
           +     +PDVQ ++Q E+D V+     P       + Y+   + E +R    + + +   
Sbjct: 318 MYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFP-IAMRLERV 376

Query: 403 TTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMI 462
              +  + G  IPK  VV +  ++++ DP  W  PE F P RF  K    NKD     + 
Sbjct: 377 CKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKK----NKDNIDPYIY 432

Query: 463 --FSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPK 514
             F  G R CIG   + M + L +  +     F+        +  S G  ++P+
Sbjct: 433 TPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPE 486


>gi|4503233 cytochrome P450, family 3, subfamily A, polypeptide 7
           [Homo sapiens]
          Length = 503

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 122/509 (23%), Positives = 206/509 (40%), Gaps = 45/509 (8%)

Query: 20  QTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLAR 79
           +T LLL +S++     G R     ++      PGP   P +GNA +  +          +
Sbjct: 10  ETWLLLAVSLILLYLYGTRTHGLFKKL---GIPGPTPLPFLGNALSFRKGYWTFDMECYK 66

Query: 80  RYGDVFQIRLGSCPIVVLNGERAIHQALVQQG-SAFADRPAFASFRVVSGGRSMAFGHYS 138
           +Y  V+ I     P++ +     I   LV++  S F +R  F     +    S+A     
Sbjct: 67  KYRKVWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKNAISIA---ED 123

Query: 139 EHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTV 198
           E WK  R    S++   FT       V    ++++  +++   +R  A+      +P+T+
Sbjct: 124 EEWKRIR----SLLSPTFTSGKLKEMV---PIIAQYGDVLVRNLRREAETG----KPVTL 172

Query: 199 VAV-----ANVMSAVCFGCRY-SHDDPE--FRELLSHNEEFGRTVGAGSLVDVMPWLQYF 250
             V      +V+++  FG    S ++P+  F E       F         + V P+L   
Sbjct: 173 KHVFGAYSMDVITSTSFGVSIDSLNNPQDPFVENTKKLLRFNPLDPFVLSIKVFPFLTPI 232

Query: 251 PNPVR-TVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSH 309
              +  TVF       R   +F L K ++  +  R     +  +D   L  + + + DS 
Sbjct: 233 LEALNITVFP------RKVISF-LTKSVKQIKEGRLKETQKHRVDFLQLMIDSQNSKDSE 285

Query: 310 GGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRL 369
              A  DLE +  +I  IF A  +T S+ L +++     +PDVQ +VQ E+D V+     
Sbjct: 286 THKALSDLELMAQSIIFIF-AGYETTSSVLSFIIYELATHPDVQQKVQKEIDTVLPNKAP 344

Query: 370 PCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNH 429
           P       L Y+   + E +R    V + +      +  + G  IPK  VV +  + ++H
Sbjct: 345 PTYDTVLQLEYLDMVVNETLRLFP-VAMRLERVCKKDVEINGMFIPKGVVVMIPSYVLHH 403

Query: 430 DPLKWPNPENFDPARFLDKDGLINKDLTSRVMI--FSVGKRRCIGEELSKMQLFLFISIL 487
           DP  W  PE F P RF  K    NKD     +   F  G R CIG   + + + L +  +
Sbjct: 404 DPKYWTEPEKFLPERFSKK----NKDNIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRV 459

Query: 488 AHQCDFRANPNEPAKMNFSYG---LTIKP 513
                F+        +   +G   LT KP
Sbjct: 460 LQNFSFKPCKETQIPLKLRFGGLLLTEKP 488


>gi|167466231 cytochrome P450, family 27, subfamily C, polypeptide 1
           [Homo sapiens]
          Length = 372

 Score = 85.1 bits (209), Expect = 1e-16
 Identities = 54/195 (27%), Positives = 93/195 (47%), Gaps = 2/195 (1%)

Query: 315 LDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGD 374
           L L+ + A +T++  A  DT S  L W + L  R+P+VQ  V  E+ + +G   +P   D
Sbjct: 165 LTLQEIYANVTEMLLAGVDTTSFTLSWTVYLLARHPEVQQTVYREIVKNLGERHVPTAAD 224

Query: 375 QPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKW 434
            P +P V A L E +R    +P      T  +  + GY IPK T + +  ++ ++    +
Sbjct: 225 VPKVPLVRALLKETLRLFPVLPGN-GRVTQEDLVIGGYLIPKGTQLALCHYATSYQDENF 283

Query: 435 PNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFR 494
           P  + F P R+L K  L   D    +  F  G R CIG  ++++++ L +  L    + +
Sbjct: 284 PRAKEFRPERWLRKGDLDRVDNFGSIP-FGHGVRSCIGRRIAELEIHLVVIQLLQHFEIK 342

Query: 495 ANPNEPAKMNFSYGL 509
            +    A    ++GL
Sbjct: 343 TSSQTNAVHAKTHGL 357


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.417 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,341,516
Number of Sequences: 37866
Number of extensions: 883973
Number of successful extensions: 2565
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 8
Number of HSP's that attempted gapping in prelim test: 2319
Number of HSP's gapped (non-prelim): 97
length of query: 543
length of database: 18,247,518
effective HSP length: 107
effective length of query: 436
effective length of database: 14,195,856
effective search space: 6189393216
effective search space used: 6189393216
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.