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Search of human proteins with 188497714
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188497714 transmembrane and coiled-coil domain family 3
[Homo sapiens]
(477 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188497714 transmembrane and coiled-coil domain family 3 [Homo... 942 0.0
gi|54792740 transmembrane and coiled-coil domain family 2 [Homo ... 474 e-134
gi|190014612 transmembrane and coiled-coil domain family 1 isofo... 427 e-119
gi|190014610 transmembrane and coiled-coil domain family 1 isofo... 427 e-119
gi|39930343 transmembrane and coiled-coil domain family 1 isofor... 286 4e-77
gi|4503177 testis expressed 28 [Homo sapiens] 84 3e-16
gi|190341068 forkhead-associated (FHA) phosphopeptide binding do... 50 3e-06
gi|56550047 uveal autoantigen with coiled-coil domains and ankyr... 47 3e-05
gi|59850762 uveal autoantigen with coiled-coil domains and ankyr... 47 3e-05
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 45 1e-04
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 44 3e-04
gi|81295809 pericentrin [Homo sapiens] 43 7e-04
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens] 42 0.001
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens] 42 0.001
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 41 0.002
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 41 0.002
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 40 0.004
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 40 0.004
gi|224451082 cytospin A [Homo sapiens] 40 0.005
gi|224451080 cytospin A [Homo sapiens] 40 0.005
gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo... 40 0.005
gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo... 40 0.005
gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo... 40 0.006
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 39 0.010
gi|4758650 kinesin family member 5C [Homo sapiens] 39 0.010
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 39 0.014
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 39 0.014
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 39 0.014
gi|7661788 mediator complex subunit 4 [Homo sapiens] 39 0.014
gi|4503593 epidermal growth factor receptor pathway substrate 15... 38 0.018
>gi|188497714 transmembrane and coiled-coil domain family 3 [Homo
sapiens]
Length = 477
Score = 942 bits (2435), Expect = 0.0
Identities = 477/477 (100%), Positives = 477/477 (100%)
Query: 1 MPGSDTALTVDRTYSDPGRHHRCKSRVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILD 60
MPGSDTALTVDRTYSDPGRHHRCKSRVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILD
Sbjct: 1 MPGSDTALTVDRTYSDPGRHHRCKSRVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILD 60
Query: 61 FHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQ 120
FHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQ
Sbjct: 61 FHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQ 120
Query: 121 KSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPHC 180
KSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPHC
Sbjct: 121 KSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPHC 180
Query: 181 MESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYG 240
MESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYG
Sbjct: 181 MESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYG 240
Query: 241 GSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDT 300
GSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDT
Sbjct: 241 GSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDT 300
Query: 301 QAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELAS 360
QAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELAS
Sbjct: 301 QAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELAS 360
Query: 361 IEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVLLGRCINVILA 420
IEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVLLGRCINVILA
Sbjct: 361 IEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVLLGRCINVILA 420
Query: 421 FMTVILVCVSTIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIERMIIPR 477
FMTVILVCVSTIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIERMIIPR
Sbjct: 421 FMTVILVCVSTIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIERMIIPR 477
>gi|54792740 transmembrane and coiled-coil domain family 2 [Homo
sapiens]
Length = 709
Score = 474 bits (1220), Expect = e-134
Identities = 257/466 (55%), Positives = 327/466 (70%), Gaps = 21/466 (4%)
Query: 26 RVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTADSLKQKILKVTEQIKIE 85
+V++ D+ LSLP G +D ++ DVPDG D + K D L QKILK+TEQIKIE
Sbjct: 249 KVDKGDLVALSLPAG--HGDTDGPISLDVPDGAPDPQRTKAAIDHLHQKILKITEQIKIE 306
Query: 86 QTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQ 145
Q +RD NVAEYLKL NNADKQQ RIKQVFEKKNQKSA +IAQL KKLE Y R+L+EIEQ
Sbjct: 307 QEARDDNVAEYLKLANNADKQQVSRIKQVFEKKNQKSAQTIAQLHKKLEHYRRRLKEIEQ 366
Query: 146 NGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPH-----CMESSKSGMPGVSLTPPVFVF 200
NG SR KD+ L+D+ + LKD R +E K + G+S V
Sbjct: 367 NGPSRQPKDV----LRDMQQGLKDVGANVRAGISGFGGGVVEGVKGSLSGLSQATHTAVV 422
Query: 201 NKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSG 260
+K REFA+LIRNKFGSADNIAHLK+ LE+ PE +ARA GSAT+V+ PKYGSDDECSS
Sbjct: 423 SKPREFASLIRNKFGSADNIAHLKDPLEDGPPEEAARALSGSATLVSSPKYGSDDECSSA 482
Query: 261 TSGSADSNGNQSFGAGGA-------STLDSQGKLAVILEELREIKDTQAQLAEDIEALKV 313
++ SA + N G GGA + + G L +LEELREIK+ Q+ L + +E LK
Sbjct: 483 SASSAGAGSNSGAGPGGALGSPKSNALYGAPGNLDALLEELREIKEGQSHLEDSMEDLKT 542
Query: 314 QFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERS 373
Q +R+Y +++Q LQEERYRYERLE+QL+DLT+LHQ+E NLKQELAS+EEKVAYQ+YER+
Sbjct: 543 QLQRDYTYMTQCLQEERYRYERLEEQLNDLTELHQNEMTNLKQELASMEEKVAYQSYERA 602
Query: 374 RDIQEALESCQTRISKLELHQQEQQALQTDTV---NAKVLLGRCINVILAFMTVILVCVS 430
RDIQEA+ESC TR++KLEL QQ+QQ +Q + V NA+ LLG+ INVILA M V+LV VS
Sbjct: 603 RDIQEAVESCLTRVTKLELQQQQQQVVQLEGVENANARALLGKFINVILALMAVLLVFVS 662
Query: 431 TIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIERMIIP 476
TIA F++P+MK+R I T V +L + K+WD + +E +++P
Sbjct: 663 TIANFITPLMKTRLRITSTTLLVLVLFLLWKHWDSLTYLLEHVLLP 708
>gi|190014612 transmembrane and coiled-coil domain family 1 isoform
c [Homo sapiens]
Length = 539
Score = 427 bits (1098), Expect = e-119
Identities = 239/460 (51%), Positives = 314/460 (68%), Gaps = 17/460 (3%)
Query: 26 RVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTADSLKQKILKVTEQIKIE 85
R+ER ++++L+ + +D +++ D DG D + K L+QKILK+TEQIKI
Sbjct: 78 RIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIA 137
Query: 86 QTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQ 145
QT+RD NVAEYLKL N+ADKQQA RIKQVFEKKNQKSA +I QLQKKLE YHRKLRE+EQ
Sbjct: 138 QTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQ 197
Query: 146 NGASRSSKDISKDHLKDIHRSLKDAHVK-SRTAPHCMESSKSGMPGVSL---TPPVFVFN 201
NG R KD+ +D+H+ LKD K + + ++S K G S + V +
Sbjct: 198 NGIPRQPKDV----FRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVS 253
Query: 202 KSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSGT 261
K RE A+LIRNKFGSADNI +LK+SLEE + + + +A G + + PKYGS+++CSS T
Sbjct: 254 KPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSAT 313
Query: 262 SGSADSNGNQSFGAGGAS-----TLDSQGK-LAVILEELREIKDTQAQLAEDIEALKVQF 315
SGS +N A GAS TLD Q +L E++EI++TQA+L E E LK +
Sbjct: 314 SGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHY 373
Query: 316 KREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRD 375
+R+Y I QTLQEERYR ERLE+QL+DLT+LHQ+E NLKQELAS+EEK+AYQ+YER+RD
Sbjct: 374 QRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARD 433
Query: 376 IQEALESCQTRISKLELHQQEQQALQ---TDTVNAKVLLGRCINVILAFMTVILVCVSTI 432
IQEALE+CQTRISK+EL QQ+QQ +Q + A+ LLG+ IN++LA M V+LV VST+
Sbjct: 434 IQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTV 493
Query: 433 AKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIER 472
A V P+MK+R T F V +A K+WD + +ER
Sbjct: 494 ANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVER 533
>gi|190014610 transmembrane and coiled-coil domain family 1 isoform
a [Homo sapiens]
Length = 653
Score = 427 bits (1098), Expect = e-119
Identities = 239/460 (51%), Positives = 314/460 (68%), Gaps = 17/460 (3%)
Query: 26 RVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTADSLKQKILKVTEQIKIE 85
R+ER ++++L+ + +D +++ D DG D + K L+QKILK+TEQIKI
Sbjct: 192 RIERLEVSSLAQTSSAVASSTDGSIHTDSVDGTPDPQRTKAAIAHLQQKILKLTEQIKIA 251
Query: 86 QTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREIEQ 145
QT+RD NVAEYLKL N+ADKQQA RIKQVFEKKNQKSA +I QLQKKLE YHRKLRE+EQ
Sbjct: 252 QTARDDNVAEYLKLANSADKQQAARIKQVFEKKNQKSAQTILQLQKKLEHYHRKLREVEQ 311
Query: 146 NGASRSSKDISKDHLKDIHRSLKDAHVK-SRTAPHCMESSKSGMPGVSL---TPPVFVFN 201
NG R KD+ +D+H+ LKD K + + ++S K G S + V +
Sbjct: 312 NGIPRQPKDV----FRDMHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVS 367
Query: 202 KSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSGT 261
K RE A+LIRNKFGSADNI +LK+SLEE + + + +A G + + PKYGS+++CSS T
Sbjct: 368 KPREIASLIRNKFGSADNIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSAT 427
Query: 262 SGSADSNGNQSFGAGGAS-----TLDSQGK-LAVILEELREIKDTQAQLAEDIEALKVQF 315
SGS +N A GAS TLD Q +L E++EI++TQA+L E E LK +
Sbjct: 428 SGSVGANSTTGGIAVGASSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHY 487
Query: 316 KREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRD 375
+R+Y I QTLQEERYR ERLE+QL+DLT+LHQ+E NLKQELAS+EEK+AYQ+YER+RD
Sbjct: 488 QRDYSLIMQTLQEERYRCERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARD 547
Query: 376 IQEALESCQTRISKLELHQQEQQALQ---TDTVNAKVLLGRCINVILAFMTVILVCVSTI 432
IQEALE+CQTRISK+EL QQ+QQ +Q + A+ LLG+ IN++LA M V+LV VST+
Sbjct: 548 IQEALEACQTRISKMELQQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTV 607
Query: 433 AKFVSPMMKSRCHILGTFFAVTLLAIFCKNWDHILCAIER 472
A V P+MK+R T F V +A K+WD + +ER
Sbjct: 608 ANCVVPLMKTRNRTFSTLFLVVFIAFLWKHWDALFSYVER 647
>gi|39930343 transmembrane and coiled-coil domain family 1 isoform b
[Homo sapiens]
Length = 329
Score = 286 bits (731), Expect = 4e-77
Identities = 161/323 (49%), Positives = 216/323 (66%), Gaps = 13/323 (4%)
Query: 163 IHRSLKDAHVK-SRTAPHCMESSKSGMPGVSL---TPPVFVFNKSREFANLIRNKFGSAD 218
+H+ LKD K + + ++S K G S + V +K RE A+LIRNKFGSAD
Sbjct: 1 MHQGLKDVGAKVTGFSEGVVDSVKGGFSSFSQATHSAAGAVVSKPREIASLIRNKFGSAD 60
Query: 219 NIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGA 278
NI +LK+SLEE + + + +A G + + PKYGS+++CSS TSGS +N A GA
Sbjct: 61 NIPNLKDSLEEGQVDDAGKALGVISNFQSSPKYGSEEDCSSATSGSVGANSTTGGIAVGA 120
Query: 279 S-----TLDSQGK-LAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYR 332
S TLD Q +L E++EI++TQA+L E E LK ++R+Y I QTLQEERYR
Sbjct: 121 SSSKTNTLDMQSSGFDALLHEIQEIRETQARLEESFETLKEHYQRDYSLIMQTLQEERYR 180
Query: 333 YERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLEL 392
ERLE+QL+DLT+LHQ+E NLKQELAS+EEK+AYQ+YER+RDIQEALE+CQTRISK+EL
Sbjct: 181 CERLEEQLNDLTELHQNEILNLKQELASMEEKIAYQSYERARDIQEALEACQTRISKMEL 240
Query: 393 HQQEQQALQ---TDTVNAKVLLGRCINVILAFMTVILVCVSTIAKFVSPMMKSRCHILGT 449
QQ+QQ +Q + A+ LLG+ IN++LA M V+LV VST+A V P+MK+R T
Sbjct: 241 QQQQQQVVQLEGLENATARNLLGKLINILLAVMAVLLVFVSTVANCVVPLMKTRNRTFST 300
Query: 450 FFAVTLLAIFCKNWDHILCAIER 472
F V +A K+WD + +ER
Sbjct: 301 LFLVVFIAFLWKHWDALFSYVER 323
>gi|4503177 testis expressed 28 [Homo sapiens]
Length = 410
Score = 84.0 bits (206), Expect = 3e-16
Identities = 38/91 (41%), Positives = 63/91 (69%)
Query: 55 PDGILDFHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQV 114
P + D DS++ +IL ++EQ+++E+ SRDGN YLKLV+ AD+ Q I+Q
Sbjct: 35 PSSLADGGLAHNLQDSVRHRILYLSEQLRVEKASRDGNTVSYLKLVSKADRHQVPHIQQA 94
Query: 115 FEKKNQKSAHSIAQLQKKLEQYHRKLREIEQ 145
FEK NQ+++ +IAQ++ +L Q H++L+E+E+
Sbjct: 95 FEKVNQRASATIAQIEHRLHQCHQQLQELEE 125
Score = 82.4 bits (202), Expect = 8e-16
Identities = 55/179 (30%), Positives = 94/179 (52%), Gaps = 2/179 (1%)
Query: 287 LAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDL 346
L + EL E K L E +LK + + + ++LQEE+ R +E+Q++
Sbjct: 202 LQKVKAELEEAKRFHISLQESYHSLKERSLTDLQLLLESLQEEKCRQALMEEQVNGRLQG 261
Query: 347 HQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVN 406
+E NLK LA EE++AY +YER+++I E E+ ++RISKLE+ QQ Q + +
Sbjct: 262 QLNEIYNLKHNLACSEERMAYLSYERAKEIWEITETFKSRISKLEMLQQVTQLEAAEHLQ 321
Query: 407 AK--VLLGRCINVILAFMTVILVCVSTIAKFVSPMMKSRCHILGTFFAVTLLAIFCKNW 463
++ +L + ++ L+ TV+LV VST+ S ++ SR + L + + W
Sbjct: 322 SRPPQMLFKFLSPRLSLATVLLVFVSTLCACPSSLISSRLCTCTMLMLIGLGVLAWQRW 380
>gi|190341068 forkhead-associated (FHA) phosphopeptide binding
domain 1 [Homo sapiens]
Length = 1412
Score = 50.4 bits (119), Expect = 3e-06
Identities = 82/414 (19%), Positives = 176/414 (42%), Gaps = 60/414 (14%)
Query: 23 CKSRVERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKV--KLTADSLKQKILKVTE 80
CK++++ + L +R+ ++ ++ + + + KV KL DS ++K+L++ E
Sbjct: 418 CKTQIQDMEKEMKKLRAELRKSCTEQSV---ISRTLREKSKVEEKLQEDS-RRKLLQLQE 473
Query: 81 Q------IKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKK--NQKSAHSIAQLQKK 132
IKI G + + V A GR K +K +Q+ I Q+ +
Sbjct: 474 MGNRESVIKINLERAVGQLEHFRSQVIKATY---GRAKPFRDKPVTDQQLIEKITQVTED 530
Query: 133 LEQYHRKLREIE-QNGASRSSKDISKDHLKDIHRSLKD--AHVKSRTAPHCMESSKSGMP 189
+ +K ++ + S S ++ + ++++ + SL A +K H ++ +
Sbjct: 531 NINFQQKKWTLQKETQLSNSKQEETTENIEKLRTSLDSCQACMKISCCSHDLKKEVDLLQ 590
Query: 190 GVSLTPPVFVFNKSREFANLIRNKFGSADNIAHL------------KNSLEEFRPEASAR 237
+ ++PPV K +++R+ + + L K+ +++F ++
Sbjct: 591 HLQVSPPVSGLQKV--VLDVLRHALSWLEEVEQLLRDLGILPSSPNKDQVQQFSGNSAVF 648
Query: 238 AYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDS-----QGKLAVILE 292
G +A + G + + G A S + G G L+ + + LE
Sbjct: 649 TAGKAAGASGRE--GEAERGEARARGEAQSQNQATDGREGGKALEEYITQERNRAKETLE 706
Query: 293 ELRE-IKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHET 351
E R+ +++ ++ LA+ +AL +E + + L+EE+ R + LE++L
Sbjct: 707 EERKRMQELESLLAQQKKALAKSITQEKNRVKEALEEEQTRVQELEERL----------- 755
Query: 352 ANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTV 405
A K+ L E +A++ R +EALES + ++ LE H +Q+ + +
Sbjct: 756 ARQKEVL---ESSIAHE----KRKAKEALESEKRKVQDLENHLTQQKEISESNI 802
Score = 29.6 bits (65), Expect = 6.3
Identities = 45/210 (21%), Positives = 82/210 (39%), Gaps = 35/210 (16%)
Query: 65 KLTADSLKQKILKVT------EQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKK 118
K+ +L ++ ++T E +K + G V+ K + D+Q ++V K
Sbjct: 315 KVLCQTLSERNSEITSLKNEGENLKRDNAITSGMVSSLQKDILAKDEQVQQLKEEVSHLK 374
Query: 119 NQK-----------SAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSL 167
+Q S S+ + + K E HR+LRE A + K ++D+ + +
Sbjct: 375 SQNKDKDHQLEALGSRCSVLKEELKQEDAHRELRE-----AQEKELKLCKTQIQDMEKEM 429
Query: 168 KDAHVKSRTAPHCMESSKSGMPGVSLTPPVFVFNKSREFAN---LIRNKFGSAD-----N 219
K + R + C E S + +L V K +E + L + G+ + N
Sbjct: 430 KKLRAELRKS--CTEQS---VISRTLREKSKVEEKLQEDSRRKLLQLQEMGNRESVIKIN 484
Query: 220 IAHLKNSLEEFRPEASARAYGGSATIVNKP 249
+ LE FR + YG + +KP
Sbjct: 485 LERAVGQLEHFRSQVIKATYGRAKPFRDKP 514
Score = 29.3 bits (64), Expect = 8.2
Identities = 15/51 (29%), Positives = 29/51 (56%), Gaps = 1/51 (1%)
Query: 352 ANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQT 402
ANL+ E+A + +KV+ R + +E + CQ ++ Q+E Q+L++
Sbjct: 255 ANLQNEVAELSQKVSETTTSRQNE-KEISQKCQVLDEDIDAKQKEIQSLKS 304
>gi|56550047 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 2 [Homo sapiens]
Length = 1403
Score = 47.4 bits (111), Expect = 3e-05
Identities = 85/366 (23%), Positives = 143/366 (39%), Gaps = 46/366 (12%)
Query: 73 QKILKVTEQIKIEQTSRDGNVAEYLK-----LVNNADKQQAGRI-KQVFEK--KNQKSAH 124
+K L Q+K E + +A+++K V + +Q++G + K++ E KNQ
Sbjct: 645 EKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQK 704
Query: 125 SIAQ--LQKKL--EQYHRKLREIEQNGAS-RSSKDISKDH---LKDIHRSLKDAHVKSRT 176
I + L KL EQ H E++ + + S+D+ K H + D++R L D K
Sbjct: 705 EIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTE 764
Query: 177 APHCMES----SKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRP 232
ME + S VS VFV + E + NI LK L E +
Sbjct: 765 KKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE-----KEIIALKSNIVELKKQLSELKK 819
Query: 233 ---EASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAV 289
E + + ++ N K S+ T N + LD + K
Sbjct: 820 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFED 879
Query: 290 ILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQH 349
I +E +IKD L ++E + Q K EY +L E + L + + D +
Sbjct: 880 INQEFVKIKDKNEILKRNLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE 935
Query: 350 ETANLK---QELASIEEKVAYQAYERSRDIQEAL----------ESCQTRISKLELHQQE 396
AN + +E+ ++ ++ Q E IQE + E C+ + E ++
Sbjct: 936 ILANYRKGQEEIVTLHAEIKAQKKELD-TIQECIKVKYAPIVSFEECERKFKATEKELKD 994
Query: 397 QQALQT 402
Q + QT
Sbjct: 995 QLSEQT 1000
>gi|59850762 uveal autoantigen with coiled-coil domains and ankyrin
repeats isoform 1 [Homo sapiens]
Length = 1416
Score = 47.4 bits (111), Expect = 3e-05
Identities = 85/366 (23%), Positives = 143/366 (39%), Gaps = 46/366 (12%)
Query: 73 QKILKVTEQIKIEQTSRDGNVAEYLK-----LVNNADKQQAGRI-KQVFEK--KNQKSAH 124
+K L Q+K E + +A+++K V + +Q++G + K++ E KNQ
Sbjct: 658 EKSLSEIRQLKRELENVKAKLAQHVKPEEHEQVKSRLEQKSGELGKKITELTLKNQTLQK 717
Query: 125 SIAQ--LQKKL--EQYHRKLREIEQNGAS-RSSKDISKDH---LKDIHRSLKDAHVKSRT 176
I + L KL EQ H E++ + + S+D+ K H + D++R L D K
Sbjct: 718 EIEKVYLDNKLLKEQAHNLTIEMKNHYVPLKVSEDMKKSHDAIIDDLNRKLLDVTQKYTE 777
Query: 177 APHCMES----SKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRP 232
ME + S VS VFV + E + NI LK L E +
Sbjct: 778 KKLEMEKLLLENDSLSKDVSRLETVFVPPEKHE-----KEIIALKSNIVELKKQLSELKK 832
Query: 233 ---EASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAV 289
E + + ++ N K S+ T N + LD + K
Sbjct: 833 KCGEDQEKIHALTSENTNLKKMMSNQYVPVKTHEEVKMTLNDTLAKTNRELLDVKKKFED 892
Query: 290 ILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQH 349
I +E +IKD L ++E + Q K EY +L E + L + + D +
Sbjct: 893 INQEFVKIKDKNEILKRNLENTQNQIKAEY----ISLAEHEAKMSSLSQSMRKVQDSNAE 948
Query: 350 ETANLK---QELASIEEKVAYQAYERSRDIQEAL----------ESCQTRISKLELHQQE 396
AN + +E+ ++ ++ Q E IQE + E C+ + E ++
Sbjct: 949 ILANYRKGQEEIVTLHAEIKAQKKELD-TIQECIKVKYAPIVSFEECERKFKATEKELKD 1007
Query: 397 QQALQT 402
Q + QT
Sbjct: 1008 QLSEQT 1013
>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
transmembrane signal), 1 [Homo sapiens]
Length = 3259
Score = 45.4 bits (106), Expect = 1e-04
Identities = 38/137 (27%), Positives = 65/137 (47%), Gaps = 13/137 (9%)
Query: 283 SQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQ---TLQEERYRYERLEDQ 339
SQ +LA + EL+ +KD L+ +E K Q G I Q +Q ++ YE+LE
Sbjct: 2303 SQNELAKLESELKSLKDQLTDLSNSLEKCKEQKGNLEGIIRQQEADIQNSKFSYEQLETD 2362
Query: 340 LHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTR----ISKLE--LH 393
L +L T+ L +E+ E+K+ + IQ A+ + + I +LE L
Sbjct: 2363 LQASREL----TSRLHEEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLS 2418
Query: 394 QQEQQALQTDTVNAKVL 410
Q+E++ + + N K +
Sbjct: 2419 QEEEENIVLEEENKKAV 2435
Score = 35.0 bits (79), Expect = 0.15
Identities = 72/385 (18%), Positives = 153/385 (39%), Gaps = 64/385 (16%)
Query: 63 KVKLTADSLKQKILKVTEQ---IKIEQTSRDGNVAEYLKLV---NNADKQQAGRIKQVFE 116
K++ A S +QKIL++ E+ ++ E E ++ + N + K++ R+K +E
Sbjct: 1677 KMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSNASMKEELERVKMEYE 1736
Query: 117 KKNQKSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRT 176
++K +++ E+ +IE N + +++ + ++ H D ++ + +S
Sbjct: 1737 TLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKH--DNQTNVTEEGTQSIP 1794
Query: 177 APHCMESSKSGMPGVSLTPPVFVFNKSREFAN-LIRNKFGSADNIAHLKNSLEEFRPEAS 235
E+ + +S P S + AN + F S D I + +++ + +
Sbjct: 1795 G----ETEEQDSLSMSTRPTCSESVPSAKSANPAVSKDFSSHDEINNYLQQIDQLKERIA 1850
Query: 236 ARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELR 295
G ++E S ++ ST D G+L ++ EE+
Sbjct: 1851 ----------------GLEEEKQKNKEFSQTLENEKNTLLSQISTKD--GELKMLQEEVT 1892
Query: 296 EIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRY-ERLEDQL-----------HDL 343
++ Q+ E++ + + +T +EE+ ERL +QL D+
Sbjct: 1893 KMNLLNQQIQEELSRVTK--------LKETAEEEKDDLEERLMNQLAELNGSIGNYCQDV 1944
Query: 344 TD------LHQHETANLKQELASIEEKVAYQAYERS-------RDIQEALESCQTRISKL 390
TD L + E NLK+ ++ +EE+ E++ ++ E ++ Q
Sbjct: 1945 TDAQIKNELLESEMKNLKKCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKEPGNK 2004
Query: 391 ELHQQEQQALQTDTVNAKVLLGRCI 415
++ Q+ L+ K L CI
Sbjct: 2005 SHAKELQELLKEKQQEVKQLQKDCI 2029
Score = 32.7 bits (73), Expect = 0.74
Identities = 34/131 (25%), Positives = 65/131 (49%), Gaps = 19/131 (14%)
Query: 282 DSQGKLAVILEELR---EIKDTQAQLAEDIEALKVQFKREYGFISQTLQ-EERYRYERLE 337
D ++++ +EEL+ + Q+ E +VQ +++ + TLQ E + +LE
Sbjct: 2238 DQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQK---VCDTLQGENKELLSQLE 2294
Query: 338 DQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQ 397
+ H L Q+E A L+ EL S+++++ D+ +LE C+ + LE ++Q
Sbjct: 2295 ETRH-LYHSSQNELAKLESELKSLKDQLT--------DLSNSLEKCKEQKGNLEGIIRQQ 2345
Query: 398 QALQTDTVNAK 408
+A D N+K
Sbjct: 2346 EA---DIQNSK 2353
Score = 30.0 bits (66), Expect = 4.8
Identities = 56/277 (20%), Positives = 112/277 (40%), Gaps = 27/277 (9%)
Query: 128 QLQKKLEQYHRKLREIEQNGASRSS-KDISKDHL-------KDIHRSLKDAHVKSRTAPH 179
++Q+KL RKL E E++ R+ D+ + L + + + L+ + T +
Sbjct: 249 EMQQKLRVLQRKLEEHEESLVGRAQVVDLLQQELTAAEQRNQILSQQLQQMEAEHNTLRN 308
Query: 180 CMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAY 239
+E+ + + + V + F NL + + HL LE+F A+A
Sbjct: 309 TVETEREESKILLEKMELEVAERKLSFHNL-------QEEMHHL---LEQFEQAGQAQAE 358
Query: 240 GGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKD 299
S + K+ ++ E + S G + A A D KL L++ +
Sbjct: 359 LESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDA-LKDQNSKL------LQDKNE 411
Query: 300 TQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQE-L 358
Q A+ I+ L+ Q +++ ISQ L + Q D++ T + +E +
Sbjct: 412 QAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHETASQT-SFPDVYNEGTQAVTEENI 470
Query: 359 ASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQ 395
AS++++V E+ + ++E + + +L Q
Sbjct: 471 ASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQ 507
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 43.9 bits (102), Expect = 3e-04
Identities = 29/113 (25%), Positives = 61/113 (53%), Gaps = 5/113 (4%)
Query: 286 KLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTD 345
+L L++ +++K ++Q+ I Q E G +S L+E ++L+D L++LT+
Sbjct: 291 RLHETLKQCQDLKTEKSQMDRKIN----QLSEENGDLSFKLREFASHLQQLQDALNELTE 346
Query: 346 LHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQ 398
H T ++ A +E++++ A + + ++E E Q ++S+LE H + Q
Sbjct: 347 EHSKATQEWLEKQAQLEKELS-AALQDKKCLEEKNEILQGKLSQLEEHLSQLQ 398
Score = 43.5 bits (101), Expect = 4e-04
Identities = 82/358 (22%), Positives = 150/358 (41%), Gaps = 44/358 (12%)
Query: 62 HKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQK 121
H +LTA ++ +T ++ + E L A ++QA ++ Q +++ Q
Sbjct: 492 HGARLTA-----QVASLTSELTTLNATIQQQDQELAGLKQQAKEKQA-QLAQTLQQQEQA 545
Query: 122 SA---HSIAQLQKKLEQYHRKLREI-EQNGASRSSKDISKDHLKDIHRSL--KDAHVKSR 175
S H + QL L+Q ++L+E+ E+ A+R +DH + + + ++A ++ R
Sbjct: 546 SQGLRHQVEQLSSSLKQKEQQLKEVAEKQEATR------QDHAQQLATAAEEREASLRER 599
Query: 176 TAP----HCMESSKSGMPGVSLTPPVFVFNKSREFANLI-----RNKFGSADNIAHLKNS 226
A +E K+ + L + V N++R+ A R K + + L+
Sbjct: 600 DAALKQLEALEKEKAAKLEI-LQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQAC 658
Query: 227 LEEFRP---EASARAYGGSATIVNKPKYGSDDECSSGTSGSADSN---GNQSFGAGGAST 280
+E R EA A+ + ++ + ++ E + +S S
Sbjct: 659 VETARQEQHEAQAQVAELELQLRSEQQKATEKERVAQEKDQLQEQLQALKESLKVTKGSL 718
Query: 281 LDSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQL 340
+ + + A LEE + ++L + +L Q KRE + L+EER + LE +L
Sbjct: 719 EEEKRRAADALEEQQR---CISELKAETRSLVEQHKRE----RKELEEERAGRKGLEARL 771
Query: 341 HDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQ 398
L + HQ ET L++ELA E +A Q S Q E R + Q+E Q
Sbjct: 772 QQLGEAHQAETEVLRRELA---EAMAAQHTAESECEQLVKEVAAWRERYEDSQQEEAQ 826
Score = 29.6 bits (65), Expect = 6.3
Identities = 23/90 (25%), Positives = 44/90 (48%), Gaps = 8/90 (8%)
Query: 72 KQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQK 131
+QK+ EQ+++ Q + V E K + AD QA +++Q K Q + Q+
Sbjct: 1530 RQKLTAQVEQLEVFQREQTKQVEELSKKL--ADSDQASKVQQQKLKAVQAQG---GESQQ 1584
Query: 132 KLEQYHRKLREIEQNGASRSSKDISKDHLK 161
+ ++ +L E++ A S K+ + +H K
Sbjct: 1585 EAQRLQAQLNELQ---AQLSQKEQAAEHYK 1611
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 42.7 bits (99), Expect = 7e-04
Identities = 40/129 (31%), Positives = 62/129 (48%), Gaps = 24/129 (18%)
Query: 301 QAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELAS 360
Q +L E+IE LK++ + YG LQ E + LE H+L + HQ E N KQ+
Sbjct: 685 QTELKEEIELLKIENRNLYG----KLQHETRLKDDLEKVKHNLIEDHQKELNNAKQKTEL 740
Query: 361 IEE---------KVAYQAYERSR---------DIQEALES-CQTRISKLELHQQEQQALQ 401
+++ KV + +R +++E ES QT I+K EL + E + LQ
Sbjct: 741 MKQEFQRKETDWKVMKEELQREAEEKLTLMLLELREKAESEKQTIINKFELREAEMRQLQ 800
Query: 402 TDTVNAKVL 410
D A++L
Sbjct: 801 -DQQAAQIL 808
Score = 34.7 bits (78), Expect = 0.20
Identities = 30/120 (25%), Positives = 55/120 (45%), Gaps = 6/120 (5%)
Query: 282 DSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLH 341
D + + + LE LR K+ A+ ++E L+ QF++E L++ + E L
Sbjct: 349 DWESEKDLCLENLR--KELSAKHQSEMEDLQNQFQKELAEQRAELEKIFQDKNQAERALR 406
Query: 342 DLTDLHQHETANLKQELASIE----EKVAYQAYERSRDIQEALESCQTRISKLELHQQEQ 397
+L HQ L+++L S E + ++ E ++ Q LE+ Q L+ QE+
Sbjct: 407 NLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELENLQASYEDLKAQSQEE 466
Score = 32.0 bits (71), Expect = 1.3
Identities = 25/82 (30%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 73 QKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKK 132
Q+ L+ Q E R+ V+ LK A Q ++ E++ +K A LQ +
Sbjct: 2819 QQQLEAEAQKHCEALRREKEVSATLKSTVEALHTQKRELRCSLEREREKPAW----LQAE 2874
Query: 133 LEQYHRKLREIEQNGASRSSKD 154
LEQ H +L+E E A+R S +
Sbjct: 2875 LEQSHPRLKEQEGRKAARRSAE 2896
>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
Length = 709
Score = 42.0 bits (97), Expect = 0.001
Identities = 63/294 (21%), Positives = 118/294 (40%), Gaps = 38/294 (12%)
Query: 66 LTADSLKQKI--LKVTEQIKIEQTSRDGNV----AEYLKLVNNADKQQAGRIKQVFEKKN 119
+ ADS ++K L V + I E +D + +E K K+++ R++ K+
Sbjct: 1 MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQ 60
Query: 120 QKSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPH 179
+ S HS + K L + I +++ ++++ + DA K R
Sbjct: 61 KPSVHSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIR---- 116
Query: 180 CMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAY 239
+ SS S P + V + E R K + D + ++ ++R+
Sbjct: 117 -LSSSASREPYKNQPEKTCVRKRDPER----RAKSPTPDGSERIGLEVDR----RASRSS 167
Query: 240 GGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKD 299
S VN +YGSD E +G+SGS+D GN +++ + + E++ E ++
Sbjct: 168 QSSKEEVNSEEYGSDHE--TGSSGSSDEQGN-----------NTENEEEGVEEDVEEDEE 214
Query: 300 TQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETAN 353
+ ED E E G + +EE E E++ ++ + Q E N
Sbjct: 215 VEEDAEEDEEV------DEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGN 262
>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
Length = 727
Score = 42.0 bits (97), Expect = 0.001
Identities = 63/294 (21%), Positives = 118/294 (40%), Gaps = 38/294 (12%)
Query: 66 LTADSLKQKI--LKVTEQIKIEQTSRDGNV----AEYLKLVNNADKQQAGRIKQVFEKKN 119
+ ADS ++K L V + I E +D + +E K K+++ R++ K+
Sbjct: 1 MAADSREEKDGELNVLDDILTEVPEQDDELYNPESEQDKNEKKGSKRKSDRMESTDTKRQ 60
Query: 120 QKSAHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPH 179
+ S HS + K L + I +++ ++++ + DA K R
Sbjct: 61 KPSVHSRQLVSKPLSSSVSNNKRIVSTKGKSATEYKNEEYQRSERNKRLDADRKIR---- 116
Query: 180 CMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEASARAY 239
+ SS S P + V + E R K + D + ++ ++R+
Sbjct: 117 -LSSSASREPYKNQPEKTCVRKRDPER----RAKSPTPDGSERIGLEVDR----RASRSS 167
Query: 240 GGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKD 299
S VN +YGSD E +G+SGS+D GN +++ + + E++ E ++
Sbjct: 168 QSSKEEVNSEEYGSDHE--TGSSGSSDEQGN-----------NTENEEEGVEEDVEEDEE 214
Query: 300 TQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETAN 353
+ ED E E G + +EE E E++ ++ + Q E N
Sbjct: 215 VEEDAEEDEEV------DEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGN 262
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 41.2 bits (95), Expect = 0.002
Identities = 73/360 (20%), Positives = 141/360 (39%), Gaps = 34/360 (9%)
Query: 66 LTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHS 125
L + Q++ K E ++ E ++ L + K++A ++++ E + S
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA-QLEKTIETLRENSERQ 552
Query: 126 IAQLQKKLEQYHR---KLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVK-------SR 175
I L+++ E ++ LR+ Q A KDI K++ K +H S+K+ K R
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN-KILHESIKETSSKLSKIEFEKR 611
Query: 176 TAPHCMESSKS-GMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEA 234
+E K G L + K E L++ K + +LE+ E
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENE---LLQKKITNLKITCEKIEALEQENSEL 668
Query: 235 SARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEEL 294
T+ + E + D N S + K+A + E
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLEN 727
Query: 295 REIKDTQAQLAEDIEALKVQFKR-------------EYGFISQTLQEERYRYERLEDQLH 341
+E++ + QL + +E LK FK+ E + +TL+ + ++LE +L
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 342 DLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQ 401
DL +Q NL++ I K Q + ++ +++ E+ Q K +L ++ ++ Q
Sbjct: 788 DLEMENQTLQKNLEE--LKISSKRLEQLEKENKSLEQ--ETSQLEKDKKQLEKENKRLRQ 843
Score = 31.6 bits (70), Expect = 1.7
Identities = 28/136 (20%), Positives = 71/136 (52%), Gaps = 22/136 (16%)
Query: 279 STLDS-QGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFI------SQTLQEERY 331
+T+DS +G + IL+ +E +L++ +E L+ + +E + S+ L +E+
Sbjct: 481 TTVDSVEGNASKILKMEKE----NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 332 RYERLEDQLHDLTD----LHQHETANLKQELASIEEKVAYQAYERSRDIQ-------EAL 380
+ E+ + L + ++ + + E +L Q ++S+ ++ A R +DI+ E++
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 381 ESCQTRISKLELHQQE 396
+ +++SK+E +++
Sbjct: 597 KETSSKLSKIEFEKRQ 612
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 41.2 bits (95), Expect = 0.002
Identities = 73/360 (20%), Positives = 141/360 (39%), Gaps = 34/360 (9%)
Query: 66 LTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHS 125
L + Q++ K E ++ E ++ L + K++A ++++ E + S
Sbjct: 494 LKMEKENQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA-QLEKTIETLRENSERQ 552
Query: 126 IAQLQKKLEQYHR---KLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVK-------SR 175
I L+++ E ++ LR+ Q A KDI K++ K +H S+K+ K R
Sbjct: 553 IKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKEN-KILHESIKETSSKLSKIEFEKR 611
Query: 176 TAPHCMESSKS-GMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLKNSLEEFRPEA 234
+E K G L + K E L++ K + +LE+ E
Sbjct: 612 QIKKELEHYKEKGERAEELENELHHLEKENE---LLQKKITNLKITCEKIEALEQENSEL 668
Query: 235 SARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEEL 294
T+ + E + D N S + K+A + E
Sbjct: 669 ERENRKLKKTLDSFKNLTFQLESLEKENSQLDEE-NLELRRNVESLKCASMKMAQLQLEN 727
Query: 295 REIKDTQAQLAEDIEALKVQFKR-------------EYGFISQTLQEERYRYERLEDQLH 341
+E++ + QL + +E LK FK+ E + +TL+ + ++LE +L
Sbjct: 728 KELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESELQ 787
Query: 342 DLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQ 401
DL +Q NL++ I K Q + ++ +++ E+ Q K +L ++ ++ Q
Sbjct: 788 DLEMENQTLQKNLEE--LKISSKRLEQLEKENKSLEQ--ETSQLEKDKKQLEKENKRLRQ 843
Score = 31.6 bits (70), Expect = 1.7
Identities = 28/136 (20%), Positives = 71/136 (52%), Gaps = 22/136 (16%)
Query: 279 STLDS-QGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFI------SQTLQEERY 331
+T+DS +G + IL+ +E +L++ +E L+ + +E + S+ L +E+
Sbjct: 481 TTVDSVEGNASKILKMEKE----NQRLSKKVEILENEIVQEKQSLQNCQNLSKDLMKEKA 536
Query: 332 RYERLEDQLHDLTD----LHQHETANLKQELASIEEKVAYQAYERSRDIQ-------EAL 380
+ E+ + L + ++ + + E +L Q ++S+ ++ A R +DI+ E++
Sbjct: 537 QLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESI 596
Query: 381 ESCQTRISKLELHQQE 396
+ +++SK+E +++
Sbjct: 597 KETSSKLSKIEFEKRQ 612
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 40.4 bits (93), Expect = 0.004
Identities = 76/388 (19%), Positives = 158/388 (40%), Gaps = 47/388 (12%)
Query: 56 DGILDFHKVKLTADSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVF 115
+G L+ K KL AD L++ K+ +K+ Q S ++ + + K++ + Q+
Sbjct: 1039 EGSLEQEK-KLRAD-LERAKRKLEGDLKMSQESIM-DLENDKQQIEEKLKKKEFELSQLQ 1095
Query: 116 EKKNQKSAHSIAQLQKKLEQYHRKLREIEQN---------GASRSSKDISKDHLKDIHRS 166
K + + HS+ Q QKK+++ ++ E+E+ + D++++ L++I
Sbjct: 1096 AKIDDEQVHSL-QFQKKIKELQARIEELEEEIEAEHTLRAKIEKQRSDLARE-LEEISER 1153
Query: 167 LKDAH---------VKSRTAPHCMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSA 217
L++A K R A + + + +L ++ A+ +
Sbjct: 1154 LEEASGATSAQIEMNKKREAE--FQKMRRDLEEATLQHEATAATLRKKQADSVAELGEQI 1211
Query: 218 DNIAHLKNSLEEFRPEASARAYGGSATI--VNKPKYGSDDECSSGTSGSADSNGNQSFGA 275
DN+ +K LE+ + E ++ I ++K K + C + ++
Sbjct: 1212 DNLQRVKQKLEKEKSELKMEIDDMASNIEALSKSKSNIERTCRTVEDQFSEIKAKDEQQT 1271
Query: 276 GGASTLDSQ--------GKLAVILEE----LREIKDTQAQLAEDIEALKVQFKRE---YG 320
L+ Q G+L+ +EE + ++ ++ L + +E LK Q + E
Sbjct: 1272 QLIHDLNMQKARLQTQNGELSHRVEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKN 1331
Query: 321 FISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEAL 380
++ LQ R+ + L +Q + Q A L++ L+ +VA + D +
Sbjct: 1332 AMAHALQSSRHDCDLLREQYEE----EQEAKAELQRALSKANSEVAQWRTKYETDAIQRT 1387
Query: 381 ESCQTRISKLELHQQEQQALQTDTVNAK 408
E + KL QE + T+T N+K
Sbjct: 1388 EELEEAKKKLAQRLQEAEE-NTETANSK 1414
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 40.4 bits (93), Expect = 0.004
Identities = 37/138 (26%), Positives = 59/138 (42%), Gaps = 21/138 (15%)
Query: 292 EELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYER---------------- 335
EEL + T + E LK + + I +T +EER ++
Sbjct: 414 EELEKALSTAQKTEEARRKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKS 473
Query: 336 LEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKL--ELH 393
E+Q+ L LH+ E A +QEL +K+ + E ++ ALE Q+ K+ E
Sbjct: 474 SEEQIAKLQKLHEKELARKEQELT---KKLQTREREFQEQMKVALEKSQSEYLKISQEKE 530
Query: 394 QQEQQALQTDTVNAKVLL 411
QQE AL+ + K +L
Sbjct: 531 QQESLALEELELQKKAIL 548
Score = 37.0 bits (84), Expect = 0.039
Identities = 73/379 (19%), Positives = 152/379 (40%), Gaps = 48/379 (12%)
Query: 80 EQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQ---KSAHSIAQLQKKLEQY 136
EQ+K+ + + + +EYLK+ ++Q++ ++++ +K +S + + LQ++ E Y
Sbjct: 509 EQMKV---ALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDLQQEAETY 565
Query: 137 HRKLREIEQNGASRSSKDISKDHLKDIHRSLKDAHVKSRTAPHCMESSKSGMPGVSLTPP 196
++ E+E + S +K+ KD+ H+++ H E +
Sbjct: 566 RTRILELE--SSLEKSLQENKNQSKDL-----AVHLEAEKNKHNKEIT------------ 606
Query: 197 VFVFNKSREFANLIRNKFGS-ADNIAHLKNSLEEFRPEASARAYGGSATIVNKPK---YG 252
V V E +L + + + LK + + + T++ +
Sbjct: 607 VMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQA 666
Query: 253 SDDECSSGTSGSADSNGN--QSFGAGGASTLDSQGKLAVILEELREIKDTQAQLAEDIEA 310
+E + T D +S + + L ++ KL EEL +KD ++ +++EA
Sbjct: 667 HIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLE---EELSVLKDQTDKMKQELEA 723
Query: 311 -LKVQFKREYGFISQTLQEERYRYER----LEDQLHDLTDLHQHETANLKQELASIEEKV 365
+ Q + ++E +R L+DQ++ L L + +LK+ A +E
Sbjct: 724 KMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLE 783
Query: 366 AYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVLLGRCINVILAFMTVI 425
A DI+ + Q +KL++ Q Q A T + L + +L T
Sbjct: 784 A--------DIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETER 835
Query: 426 LVCVSTIAKFVSPMMKSRC 444
++ +A+ V K C
Sbjct: 836 ILLTKQVAE-VEAQKKDVC 853
Score = 29.6 bits (65), Expect = 6.3
Identities = 23/116 (19%), Positives = 55/116 (47%), Gaps = 12/116 (10%)
Query: 295 REIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANL 354
+E+ + +L + ++ + +F+ + + Q E + + ++Q L
Sbjct: 487 KELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLA---------- 536
Query: 355 KQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQALQTDTVNAKVL 410
+EL ++ + ++ + RD+Q+ E+ +TRI LEL +++LQ + +K L
Sbjct: 537 LEELELQKKAILTESENKLRDLQQEAETYRTRI--LELESSLEKSLQENKNQSKDL 590
>gi|224451082 cytospin A [Homo sapiens]
Length = 1117
Score = 40.0 bits (92), Expect = 0.005
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 23/233 (9%)
Query: 116 EKKNQKS---AHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDA-H 171
++K++K AH ++ L Q EQN A R + LK+ +R LKD +
Sbjct: 223 DEKSEKETIMAHQPTDVESTLLQLQ------EQNTAIREELN----QLKNENRMLKDRLN 272
Query: 172 VKSRTAPHCMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSA-----DNIAHLKNS 226
+ +++S+ SL+P + N+S L + GSA D ++ +N+
Sbjct: 273 ALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENT 332
Query: 227 LEEFRPEASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGK 286
L + + S + V +P SDD + +S ++ + G+S S+
Sbjct: 333 LMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVS 392
Query: 287 LAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQ 339
+A + E + ++++ Q +E+++A +E + Q QE ERL ++
Sbjct: 393 VACLTERIHQMEENQHSTSEELQAT----LQELADLQQITQELNSENERLGEE 441
>gi|224451080 cytospin A [Homo sapiens]
Length = 1117
Score = 40.0 bits (92), Expect = 0.005
Identities = 52/233 (22%), Positives = 101/233 (43%), Gaps = 23/233 (9%)
Query: 116 EKKNQKS---AHSIAQLQKKLEQYHRKLREIEQNGASRSSKDISKDHLKDIHRSLKDA-H 171
++K++K AH ++ L Q EQN A R + LK+ +R LKD +
Sbjct: 223 DEKSEKETIMAHQPTDVESTLLQLQ------EQNTAIREELN----QLKNENRMLKDRLN 272
Query: 172 VKSRTAPHCMESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSA-----DNIAHLKNS 226
+ +++S+ SL+P + N+S L + GSA D ++ +N+
Sbjct: 273 ALGFSLEQRLDNSEKLFGYQSLSPEITPDNQSDGGGTLTSSVEGSAPGSVEDLLSQDENT 332
Query: 227 LEEFRPEASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLDSQGK 286
L + + S + V +P SDD + +S ++ + G+S S+
Sbjct: 333 LMDHQHSNSMDNLDSECSEVYQPLTSSDDALDAPSSSESEGIPSIERSRKGSSGNASEVS 392
Query: 287 LAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQ 339
+A + E + ++++ Q +E+++A +E + Q QE ERL ++
Sbjct: 393 VACLTERIHQMEENQHSTSEELQAT----LQELADLQQITQELNSENERLGEE 441
>gi|153791586 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 40.0 bits (92), Expect = 0.005
Identities = 73/388 (18%), Positives = 153/388 (39%), Gaps = 62/388 (15%)
Query: 63 KVKLTADSLKQKI---LKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKN 119
K+++ + K+K+ LK+ ++ ++ + + E LK ++ I + K
Sbjct: 1049 KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK-------KKEFEISNLQSKIE 1101
Query: 120 QKSAHSIAQLQKKLEQYHRKLREIEQN-GASRSSKDISKDHLKDIHRSLKDAHVKSRTAP 178
+ A I QLQKK+++ ++ E+E+ A R+S+ ++ D+ R L++ + A
Sbjct: 1102 DEQALGI-QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1160
Query: 179 HC--------------MESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLK 224
+ + + +L ++ A+ + DN+ +K
Sbjct: 1161 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 225 NSLEEFRPEASARA--YGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLD 282
LE+ + E + V+K K + C + ++ + + L
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
Query: 283 SQ-GKLAVILEEL-REIKDTQAQLA----------EDIEALKVQFKREY---GFISQTLQ 327
+Q G+L E R++ + +A ++ + IE LK Q + E ++ LQ
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 328 EERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAY-------QAYERSRDIQEAL 380
R+ + L +Q + Q A L++ L+ +VA A +R+ +++EA
Sbjct: 1341 SSRHDCDLLREQYEE----EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 381 ESCQTRISKLELHQQEQQALQTDTVNAK 408
+ R+ E H + VNAK
Sbjct: 1397 KKLAQRLQAAEEH--------VEAVNAK 1416
>gi|153792663 myosin, heavy chain 2, skeletal muscle, adult [Homo
sapiens]
Length = 1941
Score = 40.0 bits (92), Expect = 0.005
Identities = 73/388 (18%), Positives = 153/388 (39%), Gaps = 62/388 (15%)
Query: 63 KVKLTADSLKQKI---LKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKN 119
K+++ + K+K+ LK+ ++ ++ + + E LK ++ I + K
Sbjct: 1049 KLRMDLERAKRKLEGDLKLAQESIMDIENEKQQLDEKLK-------KKEFEISNLQSKIE 1101
Query: 120 QKSAHSIAQLQKKLEQYHRKLREIEQN-GASRSSKDISKDHLKDIHRSLKDAHVKSRTAP 178
+ A I QLQKK+++ ++ E+E+ A R+S+ ++ D+ R L++ + A
Sbjct: 1102 DEQALGI-QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1160
Query: 179 HC--------------MESSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIAHLK 224
+ + + +L ++ A+ + DN+ +K
Sbjct: 1161 GATSAQIEMNKKREAEFQKMRRDLEEATLQHEATAATLRKKHADSVAELGEQIDNLQRVK 1220
Query: 225 NSLEEFRPEASARA--YGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLD 282
LE+ + E + V+K K + C + ++ + + L
Sbjct: 1221 QKLEKEKSEMKMEIDDLASNVETVSKAKGNLEKMCRTLEDQLSELKSKEEEQQRLINDLT 1280
Query: 283 SQ-GKLAVILEEL-REIKDTQAQLA----------EDIEALKVQFKREY---GFISQTLQ 327
+Q G+L E R++ + +A ++ + IE LK Q + E ++ LQ
Sbjct: 1281 AQRGRLQTESGEFSRQLDEKEALVSQLSRGKQAFTQQIEELKRQLEEEIKAKNALAHALQ 1340
Query: 328 EERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAY-------QAYERSRDIQEAL 380
R+ + L +Q + Q A L++ L+ +VA A +R+ +++EA
Sbjct: 1341 SSRHDCDLLREQYEE----EQESKAELQRALSKANTEVAQWRTKYETDAIQRTEELEEAK 1396
Query: 381 ESCQTRISKLELHQQEQQALQTDTVNAK 408
+ R+ E H + VNAK
Sbjct: 1397 KKLAQRLQAAEEH--------VEAVNAK 1416
>gi|109715852 chromosome 6 open reading frame 204 isoform a [Homo
sapiens]
Length = 805
Score = 39.7 bits (91), Expect = 0.006
Identities = 28/131 (21%), Positives = 69/131 (52%), Gaps = 5/131 (3%)
Query: 286 KLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDLTD 345
+L++ EE +++++ I +LK + ++E S+ +E++ R E LE L DL
Sbjct: 465 RLSLFSEEKKKLEEKLKTRDRYISSLKKKCQKE----SEQNKEKQRRIETLEKYLADLPT 520
Query: 346 LHQHETANLKQELASIEEKVAYQAY-ERSRDIQEALESCQTRISKLELHQQEQQALQTDT 404
L ++ +L+ ++ + K +A + + ++E + CQ + ++L +++++ L T
Sbjct: 521 LDDVQSQSLQLQILEEKNKNLQEALIDTEKKLEEIKKQCQDKETQLICQKKKEKELVTTV 580
Query: 405 VNAKVLLGRCI 415
+ + + RC+
Sbjct: 581 QSLQQKVERCL 591
Score = 35.0 bits (79), Expect = 0.15
Identities = 24/86 (27%), Positives = 46/86 (53%), Gaps = 2/86 (2%)
Query: 70 SLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIK-QVFEKKNQKSAHSIAQ 128
SLK+K K +EQ K E+ R + +YL + D Q+ ++ Q+ E+KN+ ++
Sbjct: 489 SLKKKCQKESEQNK-EKQRRIETLEKYLADLPTLDDVQSQSLQLQILEEKNKNLQEALID 547
Query: 129 LQKKLEQYHRKLREIEQNGASRSSKD 154
+KKLE+ ++ ++ E + K+
Sbjct: 548 TEKKLEEIKKQCQDKETQLICQKKKE 573
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 38.9 bits (89), Expect = 0.010
Identities = 84/446 (18%), Positives = 173/446 (38%), Gaps = 67/446 (15%)
Query: 7 ALTVDRTYSDPGRHHRCKSRVERHDMNTLSLPLNIRRGGSDTNL--NFDVPDG----ILD 60
A ++R D RH + R++ H TLS GSD N D P G +
Sbjct: 464 AFQLERAIVDAARHCDLQVRID-HTSRTLSF-------GSDLNYATREDAPIGPHLQSMP 515
Query: 61 FHKVK--LTA-DSLKQKILKVTEQIKIEQTSRDGN---VAEYLKLVNNADKQQAGRIKQV 114
+++ LTA S+ K L+V + I Q + + V YLK ++ R + +
Sbjct: 516 SEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTI 575
Query: 115 FEKKNQKSAHSIAQLQKKLEQYH---RKLREIEQNGASRSSKDISKDHLKDIHRSLKDAH 171
E+K + + +I + +++LEQ +K+R+ E+ + +K+ K+ + H +K
Sbjct: 576 EERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKT 635
Query: 172 VKSRTAPHCMESSKSGMPGVSLTPPVFV---------FNKSREFANLIRNKFGSADNIAH 222
V+ R +E K G + + F +++ L + K + + +
Sbjct: 636 VRER-----LEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKN 690
Query: 223 LKNSLEEFRPEASARAYGGSATIVNKPKYGSDDECSSGTSGSADSNGNQSFGAGGASTLD 282
+ ++ F RA + K Y + + L+
Sbjct: 691 QEKKIDYFE-----RAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALE 745
Query: 283 SQGKLAVILEEL----------------REIKDTQAQLAED----IEALKVQFKREYGFI 322
+ +++ +LE+ ++K + +LAE+ +E K Q K E
Sbjct: 746 HKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRIT 805
Query: 323 SQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALES 382
+EE + E L + + + E A ++EL +E+V ++ +++
Sbjct: 806 YYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERV-----KKLEEVERKKRQ 860
Query: 383 CQTRISKLELHQQEQQALQTDTVNAK 408
+ I + E ++E++ L +++ K
Sbjct: 861 RELEIEERERRREEERRLGDSSLSRK 886
>gi|4758650 kinesin family member 5C [Homo sapiens]
Length = 957
Score = 38.9 bits (89), Expect = 0.010
Identities = 31/118 (26%), Positives = 61/118 (51%), Gaps = 16/118 (13%)
Query: 292 EELREIKDTQAQLAEDIEALKVQFK-REYGFISQT------LQEERYRYERLEDQLHDLT 344
++ R+++++Q L+E++ L+ Q K E F + LQ+ + LE Q+
Sbjct: 652 QKRRQLEESQDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHR 711
Query: 345 DLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRIS----KLELHQQEQQ 398
+ HQ + + L+ E IEEK + + RD+ + L+ Q ++S KL++ QE++
Sbjct: 712 EAHQKQLSRLRDE---IEEK--QKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQERE 764
Score = 33.9 bits (76), Expect = 0.33
Identities = 23/106 (21%), Positives = 52/106 (49%), Gaps = 7/106 (6%)
Query: 69 DSLKQKILKVTEQIKIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQ 128
DSL +++ K+ Q K+ + S E+L + +A++ + ++Q E + +++
Sbjct: 662 DSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKA-LEQQMESHREAHQKQLSR 720
Query: 129 LQKKLEQYHRKLREIE------QNGASRSSKDISKDHLKDIHRSLK 168
L+ ++E+ + + EI Q + S D +K ++D R +K
Sbjct: 721 LRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMK 766
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 38.5 bits (88), Expect = 0.014
Identities = 78/369 (21%), Positives = 150/369 (40%), Gaps = 45/369 (12%)
Query: 27 VERHDMNTLSLPLNIRRGGSDTNLNFDVPDGILDFHKVKLTA----DSLKQKILKVTEQI 82
VE+H+ SL ++ S+ N F + D K KLT LK++ + +Q
Sbjct: 419 VEQHNREVQSLKEQHQKEISELNETF-----LSDSEKEKLTLMFEIQGLKEQCENL-QQE 472
Query: 83 KIEQTSRDGNVAEYLKLVNNADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRK--- 139
K E ++ E ++++ + AG+I Q FE Q+ A + +LQ+KL +
Sbjct: 473 KQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDA 532
Query: 140 LREIEQNGASRSSKDISKDHL-KDIHRSLKDAHVKSRTAPHCMESSKSGMPGVSLTPPVF 198
L E + K +S+ L ++ ++K +++ + + + S+ L +
Sbjct: 533 LLETVNRLQGENEKLLSQQELVPELENTIK--NLQEKNGVYLLSLSQRDTMLKELEGKIN 590
Query: 199 VFNKSR-EFANLIRNKFGSADNIAHLKNSLEEFRPEASARAYGGSATIVNKPKYGSDDEC 257
+ + +F N ++N DN H K EE I+ + G E
Sbjct: 591 SLTEEKDDFINKLKNSHEEMDNF-HKKCEREE-------------RLIL---ELGKKVEQ 633
Query: 258 SSGTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKR 317
+ + + N+ G G TL + + ++L ++ L+ED E L + K
Sbjct: 634 TIQYNSELEQKVNELTG-GLEETLKEKDQND---QKLEKLMVQMKVLSEDKEVLSAEVKS 689
Query: 318 EYGFISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQ 377
Y ++ E++ LE L Q E LK+ + +E+K+ E+ ++
Sbjct: 690 LYEENNKLSSEKKQLSRDLE------VFLSQKEDVILKEHITQLEKKLQLMVEEQD-NLN 742
Query: 378 EALESCQTR 386
+ LE+ Q +
Sbjct: 743 KLLENEQVQ 751
Score = 30.0 bits (66), Expect = 4.8
Identities = 69/327 (21%), Positives = 122/327 (37%), Gaps = 56/327 (17%)
Query: 115 FEKKNQKSAHSIAQLQKKLEQYHRKLREIEQN--------GASRSSKDISKDHLKDIHRS 166
F KK ++ I +L KK+EQ + E+EQ + KD + L+ +
Sbjct: 613 FHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQ 672
Query: 167 LK----DAHVKSRTAPHCME-SSKSGMPGVSLTPPVFVFNKSREFANLIRNKFGSADNIA 221
+K D V S E ++K L+ + VF +E L ++I
Sbjct: 673 MKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVIL-------KEHIT 725
Query: 222 HLKNSLEEFRPEAS-----ARAYGGSATIVNKPKYGSDDECSSGTSGSADS----NGNQS 272
L+ L+ E V YG E S S ++ N Q+
Sbjct: 726 QLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQA 785
Query: 273 FGAGGASTLDSQGKLAV-----ILEELREIKDTQAQLA---EDIEALKVQFKREYGFISQ 324
G A + + LA +LE +EIK Q + E++++L +++E + +
Sbjct: 786 VGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRK 845
Query: 325 TLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQ 384
L+E + E L+ L E+ + EK + ++E ++C
Sbjct: 846 ELEEIQSEKEALQSDL---------------LEMKNANEKTRLENQNLLIQVEEVSQTC- 889
Query: 385 TRISKLELHQQEQQALQTDTVNAKVLL 411
SK E+H ++++ + N K LL
Sbjct: 890 ---SKSEIHNEKEKCFIKEHENLKPLL 913
Score = 29.6 bits (65), Expect = 6.3
Identities = 33/156 (21%), Positives = 62/156 (39%), Gaps = 21/156 (13%)
Query: 266 DSNGNQSFGAGGASTLDSQGKLAVILEE----LREIKDTQAQLAE---DIEALKVQFKRE 318
DS N TL S+ +LE L+E +A+L E I++ + K E
Sbjct: 1367 DSQNNLQINVSELQTLQSEHD--TLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSE 1424
Query: 319 YG-FISQTLQEERYRYERLEDQLHDLTDLHQHETANLKQELASIE--------EKVAYQA 369
+ +SQ + DQ+ L + H+ L+Q+L+ +E E
Sbjct: 1425 HTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSP 1484
Query: 370 YERSRDIQEALESCQTRISKLELH---QQEQQALQT 402
+ ++ E T + L++H ++E + ++T
Sbjct: 1485 VSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMET 1520
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 38.5 bits (88), Expect = 0.014
Identities = 30/130 (23%), Positives = 63/130 (48%), Gaps = 4/130 (3%)
Query: 278 ASTLDSQGKLAVILEELREIKDTQAQLAED--IEALKVQFKREYGFISQTLQE-ERYRYE 334
+STLD + +L L+ ++ L + ++ L+ Q + ++ I + L E E+Y+ +
Sbjct: 3313 SSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLD 3372
Query: 335 RLEDQLHDLTDLHQH-ETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELH 393
L+ + D H +T +QE + +K ++ + D+Q LE + ++ KL+L
Sbjct: 3373 SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE 3432
Query: 394 QQEQQALQTD 403
Q Q + +
Sbjct: 3433 GQRLQGIMQE 3442
Score = 30.4 bits (67), Expect = 3.7
Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 6/86 (6%)
Query: 286 KLAVILEELREIKDTQAQLAEDIEALKVQF---KREYGFISQTLQEERYRYERLEDQLHD 342
++ +++EE ++K QL E+IE + F ++ + Q LQEE +++D D
Sbjct: 821 EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD---D 877
Query: 343 LTDLHQHETANLKQELASIEEKVAYQ 368
L D + K +L ++ E++ Q
Sbjct: 878 LEDSKNKQELEYKSKLKALNEELHLQ 903
Score = 29.3 bits (64), Expect = 8.2
Identities = 24/114 (21%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 284 QGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDL 343
Q ++ + EL +KD +L E + + K+ ++QT E + L +L
Sbjct: 3130 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL 3189
Query: 344 TDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQ 397
+ + E + E+ + + +A + ++SR++Q ALE + ++ + E +E+
Sbjct: 3190 -EAFRLEVKDKTDEVHLLNDTLASEQ-KKSRELQWALEKEKAKLGRSEERDKEE 3241
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 38.5 bits (88), Expect = 0.014
Identities = 30/130 (23%), Positives = 63/130 (48%), Gaps = 4/130 (3%)
Query: 278 ASTLDSQGKLAVILEELREIKDTQAQLAED--IEALKVQFKREYGFISQTLQE-ERYRYE 334
+STLD + +L L+ ++ L + ++ L+ Q + ++ I + L E E+Y+ +
Sbjct: 3305 SSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEKHSRIVELLNETEKYKLD 3364
Query: 335 RLEDQLHDLTDLHQH-ETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELH 393
L+ + D H +T +QE + +K ++ + D+Q LE + ++ KL+L
Sbjct: 3365 SLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLE 3424
Query: 394 QQEQQALQTD 403
Q Q + +
Sbjct: 3425 GQRLQGIMQE 3434
Score = 30.4 bits (67), Expect = 3.7
Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 6/86 (6%)
Query: 286 KLAVILEELREIKDTQAQLAEDIEALKVQF---KREYGFISQTLQEERYRYERLEDQLHD 342
++ +++EE ++K QL E+IE + F ++ + Q LQEE +++D D
Sbjct: 821 EIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKD---D 877
Query: 343 LTDLHQHETANLKQELASIEEKVAYQ 368
L D + K +L ++ E++ Q
Sbjct: 878 LEDSKNKQELEYKSKLKALNEELHLQ 903
Score = 29.3 bits (64), Expect = 8.2
Identities = 24/114 (21%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 284 QGKLAVILEELREIKDTQAQLAEDIEALKVQFKREYGFISQTLQEERYRYERLEDQLHDL 343
Q ++ + EL +KD +L E + + K+ ++QT E + L +L
Sbjct: 3122 QSQMLEMQVELSSMKDRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKEL 3181
Query: 344 TDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQ 397
+ + E + E+ + + +A + ++SR++Q ALE + ++ + E +E+
Sbjct: 3182 -EAFRLEVKDKTDEVHLLNDTLASEQ-KKSRELQWALEKEKAKLGRSEERDKEE 3233
>gi|7661788 mediator complex subunit 4 [Homo sapiens]
Length = 270
Score = 38.5 bits (88), Expect = 0.014
Identities = 36/121 (29%), Positives = 57/121 (47%), Gaps = 18/121 (14%)
Query: 58 ILDFHKVKLTADSLKQKILKVTEQIKIEQT--SRDGNVAEYLKLVNNADKQQAGRIKQVF 115
+L +++ A S QK+L+ E+ ++ + RDG E +KL N K QV
Sbjct: 39 VLSRELIEMLAISRNQKLLQAGEENQVLELLIHRDGEFQELMKLALNQGKIH--HEMQVL 96
Query: 116 EKKNQKSAHSIAQLQKKLE-----------QYHRKLREIEQNGASRSSKDISKDHLKDIH 164
EK+ +K I QLQK+L+ Q KL+ IE+ +R S++ +K H
Sbjct: 97 EKEVEKRDSDIQQLQKQLKEAEQILATAVYQAKEKLKSIEK---ARKGAISSEEIIKYAH 153
Query: 165 R 165
R
Sbjct: 154 R 154
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 38.1 bits (87), Expect = 0.018
Identities = 35/166 (21%), Positives = 77/166 (46%), Gaps = 28/166 (16%)
Query: 260 GTSGSADSNGNQSFGAGGASTLDSQGKLAVILEELREIKDTQAQLAEDIEALKVQFKREY 319
G+S AD + + +D Q + + ++L+E +DT Q +++ L+ + +RE
Sbjct: 322 GSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQREN 381
Query: 320 GFISQTLQEERYRYERLEDQLHD---------------------LTDLHQHETANLKQEL 358
+ Q LQ ++ + + L D+L + L + E + + ++
Sbjct: 382 TNL-QKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQI 440
Query: 359 ASIEEKVAYQAYERSR------DIQEALESCQTRISKLELHQQEQQ 398
++ EE++A E SR +++E++ES + ++ L+ H Q+ Q
Sbjct: 441 STYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQ 486
Score = 30.8 bits (68), Expect = 2.8
Identities = 20/78 (25%), Positives = 41/78 (52%), Gaps = 2/78 (2%)
Query: 334 ERLEDQLHDLTDLHQHETANLKQELASIEEKVAYQAYERSRDIQEALESCQTRISKLELH 393
+ L+ +++ DL Q E N++Q+L E+ + + E +D+Q+ ++ T + KL+
Sbjct: 333 KELDTLNNEIVDL-QREKNNVEQDLKEKEDTIKQRTSE-VQDLQDEVQRENTNLQKLQAQ 390
Query: 394 QQEQQALQTDTVNAKVLL 411
+Q+ Q L + K L
Sbjct: 391 KQQVQELLDELDEQKAQL 408
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.366
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,640,814
Number of Sequences: 37866
Number of extensions: 701236
Number of successful extensions: 4949
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 357
Number of HSP's that attempted gapping in prelim test: 4057
Number of HSP's gapped (non-prelim): 1246
length of query: 477
length of database: 18,247,518
effective HSP length: 106
effective length of query: 371
effective length of database: 14,233,722
effective search space: 5280710862
effective search space used: 5280710862
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.