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Search of human proteins with 188497618
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188497618 connector enhancer of kinase suppressor of Ras 1
[Homo sapiens]
(713 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188497618 connector enhancer of kinase suppressor of Ras 1 [H... 1459 0.0
gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Ho... 199 7e-51
gi|74316006 CNKSR family member 3 [Homo sapiens] 181 2e-45
gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1 [... 142 1e-33
gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1 [... 142 1e-33
gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [H... 142 1e-33
gi|238859653 pleckstrin homology domain containing family A memb... 67 7e-11
gi|238859651 pleckstrin homology domain containing family A memb... 67 7e-11
gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [H... 57 6e-08
gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [H... 55 2e-07
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens] 55 3e-07
gi|50980301 myosin phosphatase-Rho interacting protein isoform 2... 54 7e-07
gi|50980307 myosin phosphatase-Rho interacting protein isoform 1... 54 7e-07
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens] 53 1e-06
gi|219689123 pleckstrin homology domain containing, family A mem... 52 2e-06
gi|19923493 pleckstrin homology domain containing, family A memb... 52 2e-06
gi|4758968 cytohesin 3 [Homo sapiens] 52 2e-06
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens] 52 2e-06
gi|7019505 cytohesin 4 [Homo sapiens] 50 6e-06
gi|195972859 cytohesin 2 isoform 2 [Homo sapiens] 50 7e-06
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 49 2e-05
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 49 2e-05
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 49 2e-05
gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens] 48 4e-05
gi|239047795 pleckstrin homology domain containing, family A mem... 47 5e-05
gi|47132519 Ras association and pleckstrin homology domains 1 is... 47 5e-05
gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [... 47 6e-05
gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo ... 47 8e-05
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 46 1e-04
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens] 45 3e-04
>gi|188497618 connector enhancer of kinase suppressor of Ras 1 [Homo
sapiens]
Length = 713
Score = 1459 bits (3777), Expect = 0.0
Identities = 713/713 (100%), Positives = 713/713 (100%)
Query: 1 MEPVETWTPGKVATWLRGLDDSLQDYPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELI 60
MEPVETWTPGKVATWLRGLDDSLQDYPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELI
Sbjct: 1 MEPVETWTPGKVATWLRGLDDSLQDYPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELI 60
Query: 61 LGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCAKTPIDVLCAAVELLH 120
LGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCAKTPIDVLCAAVELLH
Sbjct: 61 LGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCAKTPIDVLCAAVELLH 120
Query: 121 EADALLFWLSRYLFSHLNDFSACQEIRDLLEELSQVLHEDGPAAEKEGTVLRICSHVAGI 180
EADALLFWLSRYLFSHLNDFSACQEIRDLLEELSQVLHEDGPAAEKEGTVLRICSHVAGI
Sbjct: 121 EADALLFWLSRYLFSHLNDFSACQEIRDLLEELSQVLHEDGPAAEKEGTVLRICSHVAGI 180
Query: 181 CHNILVCCPKELLEQKAVLEQVQLDSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPG 240
CHNILVCCPKELLEQKAVLEQVQLDSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPG
Sbjct: 181 CHNILVCCPKELLEQKAVLEQVQLDSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPG 240
Query: 241 DEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPS 300
DEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPS
Sbjct: 241 DEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPS 300
Query: 301 LSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGT 360
LSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGT
Sbjct: 301 LSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGT 360
Query: 361 PGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRR 420
PGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRR
Sbjct: 361 PGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRR 420
Query: 421 WFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTL 480
WFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTL
Sbjct: 421 WFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTL 480
Query: 481 TDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPL 540
TDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPL
Sbjct: 481 TDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPL 540
Query: 541 HGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSF 600
HGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSF
Sbjct: 541 HGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSF 600
Query: 601 MRRNRDPQLNERVHRVRALQSTLKAKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSE 660
MRRNRDPQLNERVHRVRALQSTLKAKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSE
Sbjct: 601 MRRNRDPQLNERVHRVRALQSTLKAKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSE 660
Query: 661 GLGAWGVAQAEGSSHILTSDSTEQSPHSLPSDPEEHSHLCPLTSESSLRPPDL 713
GLGAWGVAQAEGSSHILTSDSTEQSPHSLPSDPEEHSHLCPLTSESSLRPPDL
Sbjct: 661 GLGAWGVAQAEGSSHILTSDSTEQSPHSLPSDPEEHSHLCPLTSESSLRPPDL 713
>gi|41393057 connector enhancer of kinase suppressor of Ras 2 [Homo
sapiens]
Length = 1034
Score = 199 bits (506), Expect = 7e-51
Identities = 129/367 (35%), Positives = 196/367 (53%), Gaps = 24/367 (6%)
Query: 1 MEPVETWTPGKVATWLRGLDDSLQDY--PFEDWQLPGKNLLQLCPQSLEALAVRSLGHQE 58
MEPV W+P +V W++GLDD LQ Y FE ++ G LL++ Q LE L V +GHQE
Sbjct: 5 MEPVSKWSPSQVVDWMKGLDDCLQQYIKNFEREKISGDQLLRITHQELEDLGVSRIGHQE 64
Query: 59 LILGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGD-------CAKTPIDV 111
LIL V+ L AL+ L+TENL++L+ L + + Q+ + G K P D
Sbjct: 65 LILEAVDLLCALNYGLETENLKTLSHKLNASAKNLQNFITGRRRSGHYDGRTSRKLPNDF 124
Query: 112 LCAAVELLHEADALLFWLSRYLFSHLNDFSACQE-IRDLLEELSQVLHEDGPAAEKEGTV 170
L + V+L+ A +LL WL R F+ + D+S + + L EL+ ++ +D E E +
Sbjct: 125 LTSVVDLIGAAKSLLAWLDRSPFAAVTDYSVTRNNVIQLCLELTTIVQQDCTVYETENKI 184
Query: 171 LRICSHVAGICHNILVCCPKELLEQKAVLEQVQL-----DSPLGLEIHTTSNCQHFVSQV 225
L +C ++G+C +I+ L+ Q A LE +QL LG+ I +T + H ++
Sbjct: 185 LHVCKTLSGVCDHIISLSSDPLVSQSAHLEVIQLANIKPSEGLGMYIKSTYDGLHVITGT 244
Query: 226 DTQVPTDSRLQIQPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQ 285
P D +I GDEV+Q+N Q VVGW KN+V L +P+G+ L LKK P++
Sbjct: 245 TENSPADRCKKIHAGDEVIQVNHQTVVGWQLKNLVNALREDPSGVILTLKK--RPQSMLT 302
Query: 286 TPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPI 345
+ P +L + R L+L PL PR+P+ V ++ S +P DS++L +P
Sbjct: 303 SAPALL--KNMRWKPLALQPLIPRSPTSSV-----ATPSSTISTPTKRDSSALQDLYIPP 355
Query: 346 PPEPPAI 352
PP P I
Sbjct: 356 PPAEPYI 362
Score = 128 bits (321), Expect = 2e-29
Identities = 59/160 (36%), Positives = 94/160 (58%), Gaps = 2/160 (1%)
Query: 374 RKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYR 433
+KK+KG S+RR+SC++LGR DC+GWL +K + +W++ WFVLK +LYWY
Sbjct: 548 KKKNKGPIAGKSKRRISCKDLGRGDCEGWLWKKKDAKSYFSQKWKKYWFVLKDASLYWYI 607
Query: 434 QPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITC 493
+DEKAEG I++ + ++ + +KKY F+ H K F FAA+ L D++ W+ +
Sbjct: 608 NEEDEKAEGFISLPEFKIDRASECRKKYAFKACHPKIKSFYFAAEHLDDMNRWLNRINML 667
Query: 494 ISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSP 533
+ Y R +E+D +SE++ E+ D + SP P
Sbjct: 668 TAGYAERERI--KQEQDYWSESDKEEADTPSTPKQDSPPP 705
Score = 84.7 bits (208), Expect = 3e-16
Identities = 47/151 (31%), Positives = 84/151 (55%), Gaps = 13/151 (8%)
Query: 520 PDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRT--------SFGSLTDSSEE--- 568
P D +H +P A P D P + + G ++S EE
Sbjct: 848 PRDSGFNHCCLNAPVSACDP-QDDVQPPEVEEEEEEEEEEGEAAGENIGEKSESREEKLG 906
Query: 569 -ALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKAKL 627
+L+ + R L Q +S LG+ + T+ +++ SF++R DP +NE++HR+R L+STLKA+
Sbjct: 907 DSLQDLYRALEQASLSPLGEHRISTKMEYKLSFIKRCNDPVMNEKLHRLRILKSTLKARE 966
Query: 628 QELQVLEEVLGDPELTGEKFRQWKEQNRELY 658
E+ ++++VL +P+LT ++F+QWK+ +L+
Sbjct: 967 GEVAIIDKVLDNPDLTSKEFQQWKQMYLDLF 997
>gi|74316006 CNKSR family member 3 [Homo sapiens]
Length = 555
Score = 181 bits (459), Expect = 2e-45
Identities = 129/391 (32%), Positives = 196/391 (50%), Gaps = 50/391 (12%)
Query: 1 MEPVETWTPGKVATWLRGLDDSLQDY--PFEDWQLPGKNLLQLCPQSLEALAVRSLGHQE 58
MEPV W+P +V W RGLDD LQ Y FE ++ G+ LLQ+ Q LE L V +GHQE
Sbjct: 1 MEPVTKWSPKQVVDWTRGLDDCLQQYVHKFEREKINGEQLLQISHQDLEELGVTRIGHQE 60
Query: 59 LILGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCA-------KTPIDV 111
L+L V+ L AL+ L+T+N+++L L ++H+ Q+ + A K P +
Sbjct: 61 LVLEAVDLLCALNYGLETDNMKNLVLKLRASSHNLQNYISSRRKSPAYDGNTSRKAPNEF 120
Query: 112 LCAAVELLHEADALLFWLSRYLFSHLNDFSACQ-EIRDLLEELSQVLHEDGPAAEKEGTV 170
L + VEL+ A ALL WL R F+ + DFS + +I L +L+ + +D AE E V
Sbjct: 121 LTSVVELIGAAKALLAWLDRAPFTGITDFSVTKNKIIQLCLDLTTTVQKDCFVAEMEDKV 180
Query: 171 LRICSHVAGICHNILVCCPKELLEQKAVLEQVQLDS-----PLGLEIHTTSNCQHFVSQV 225
L + + GIC + ++ Q A LE+V L + LG+ I +T + H ++
Sbjct: 181 LTVVKVLNGICDKTIRSTTDPVMSQCACLEEVHLPNIKPGEGLGMYIKSTYDGLHVITGT 240
Query: 226 DTQVPTDSRLQIQPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIP------- 278
P D +I GDEV+Q+N+Q VVGW KN+V++L P G+ L+LKK P
Sbjct: 241 TENSPADRSQKIHAGDEVIQVNQQTVVGWQLKNLVKKLRENPTGVVLLLKKRPTGSFNFT 300
Query: 279 -------------IPETPP----QTPPQVLDSPHQRSPSLSL------APLSPRAPSED- 314
+ +PP Q+P +D+ ++ S L P P +P ++
Sbjct: 301 PAPLKNLRWKPPLVQTSPPPATTQSPESTMDTSLKKEKSAILDLYIPPPPAVPYSPRDEN 360
Query: 315 -VFAFDLSS---NPSPGPSPAWTDSASLGPE 341
F + SS P PGP + + ++ L E
Sbjct: 361 GSFVYGGSSKCKQPLPGPKGSESPNSFLDQE 391
>gi|194733753 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 142 bits (357), Expect = 1e-33
Identities = 66/192 (34%), Positives = 115/192 (59%), Gaps = 8/192 (4%)
Query: 374 RKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYR 433
R+K++G T +SRRR+SC++LG DC GWL +K G F+ +W++ W +LKG +LYWY
Sbjct: 21 RRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYS 79
Query: 434 QPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITC 493
EKA+G +N+ ++++E + KKK+ F+++H K F FAA+ + ++++W+ L +
Sbjct: 80 NQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSA 139
Query: 494 ISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQR 553
+ +S ++E+CYSE+E EDP E + + P A L + +++P+
Sbjct: 140 VIHQES-----TTKDEECYSESEQEDP--EIAAETPPPPHASQTQSLTAQQASSSSPSLS 192
Query: 554 SPRTSFGSLTDS 565
SF SL ++
Sbjct: 193 GTSYSFSSLENT 204
Score = 88.6 bits (218), Expect = 2e-17
Identities = 44/133 (33%), Positives = 77/133 (57%), Gaps = 8/133 (6%)
Query: 565 SSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLK 624
S ++ +E + + L Q +S LG +P T+++ R SF++R ++P +NE++H++R L STLK
Sbjct: 309 SEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLK 368
Query: 625 AKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQAEGSSHILTSDSTEQ 684
K +L ++ ++L DP+LT K+R+WK N L + + Q + +S D T+
Sbjct: 369 CKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQD------IYQQQRASP--APDDTDD 420
Query: 685 SPHSLPSDPEEHS 697
+P L P S
Sbjct: 421 TPQELKKSPSSPS 433
>gi|194733747 phosphoinositide-binding protein PIP3-E isoform 1
[Homo sapiens]
Length = 438
Score = 142 bits (357), Expect = 1e-33
Identities = 66/192 (34%), Positives = 115/192 (59%), Gaps = 8/192 (4%)
Query: 374 RKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYR 433
R+K++G T +SRRR+SC++LG DC GWL +K G F+ +W++ W +LKG +LYWY
Sbjct: 21 RRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYS 79
Query: 434 QPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITC 493
EKA+G +N+ ++++E + KKK+ F+++H K F FAA+ + ++++W+ L +
Sbjct: 80 NQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSA 139
Query: 494 ISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQR 553
+ +S ++E+CYSE+E EDP E + + P A L + +++P+
Sbjct: 140 VIHQES-----TTKDEECYSESEQEDP--EIAAETPPPPHASQTQSLTAQQASSSSPSLS 192
Query: 554 SPRTSFGSLTDS 565
SF SL ++
Sbjct: 193 GTSYSFSSLENT 204
Score = 88.6 bits (218), Expect = 2e-17
Identities = 44/133 (33%), Positives = 77/133 (57%), Gaps = 8/133 (6%)
Query: 565 SSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLK 624
S ++ +E + + L Q +S LG +P T+++ R SF++R ++P +NE++H++R L STLK
Sbjct: 309 SEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLK 368
Query: 625 AKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQAEGSSHILTSDSTEQ 684
K +L ++ ++L DP+LT K+R+WK N L + + Q + +S D T+
Sbjct: 369 CKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQD------IYQQQRASP--APDDTDD 420
Query: 685 SPHSLPSDPEEHS 697
+P L P S
Sbjct: 421 TPQELKKSPSSPS 433
>gi|40354212 phosphoinositide-binding protein PIP3-E isoform 2 [Homo
sapiens]
Length = 437
Score = 142 bits (357), Expect = 1e-33
Identities = 66/192 (34%), Positives = 115/192 (59%), Gaps = 8/192 (4%)
Query: 374 RKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYR 433
R+K++G T +SRRR+SC++LG DC GWL +K G F+ +W++ W +LKG +LYWY
Sbjct: 20 RRKTQGFLT-MSRRRISCKDLGHADCQGWLYKKKEKGSFLSNKWKKFWVILKGSSLYWYS 78
Query: 434 QPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITC 493
EKA+G +N+ ++++E + KKK+ F+++H K F FAA+ + ++++W+ L +
Sbjct: 79 NQMAEKADGFVNLPDFTVERASECKKKHAFKISHPQIKTFYFAAENVQEMNVWLNKLGSA 138
Query: 494 ISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQR 553
+ +S ++E+CYSE+E EDP E + + P A L + +++P+
Sbjct: 139 VIHQES-----TTKDEECYSESEQEDP--EIAAETPPPPHASQTQSLTAQQASSSSPSLS 191
Query: 554 SPRTSFGSLTDS 565
SF SL ++
Sbjct: 192 GTSYSFSSLENT 203
Score = 88.6 bits (218), Expect = 2e-17
Identities = 44/133 (33%), Positives = 77/133 (57%), Gaps = 8/133 (6%)
Query: 565 SSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLK 624
S ++ +E + + L Q +S LG +P T+++ R SF++R ++P +NE++H++R L STLK
Sbjct: 308 SEDDEMEKLYKSLEQASLSPLGDRRPSTKKELRKSFVKRCKNPSINEKLHKIRTLNSTLK 367
Query: 625 AKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQAEGSSHILTSDSTEQ 684
K +L ++ ++L DP+LT K+R+WK N L + + Q + +S D T+
Sbjct: 368 CKEHDLAMINQLLDDPKLTARKYREWKVMNTLLIQD------IYQQQRASP--APDDTDD 419
Query: 685 SPHSLPSDPEEHS 697
+P L P S
Sbjct: 420 TPQELKKSPSSPS 432
>gi|238859653 pleckstrin homology domain containing family A member
4 isoform 2 [Homo sapiens]
Length = 583
Score = 66.6 bits (161), Expect = 7e-11
Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 41/212 (19%)
Query: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLE---SGHDQ 457
GWL + + G + W+RRWFVL GH L++Y+ ++E G + + +Y++ G +
Sbjct: 59 GWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPR 115
Query: 458 KKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEA 517
+++ F H + ++ AADTL DL W+R L GRA S E
Sbjct: 116 GRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL----------GRA---------SRAEG 156
Query: 518 EDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGL 577
+D + SPA+ P G P P R G +++S E + R
Sbjct: 157 DD-------YGQPRSPARP-QPGEGPGGPGGPP--EVSRGEEGRISESPE-----VTRLS 201
Query: 578 RQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQL 609
R G L P P T + MRR R P L
Sbjct: 202 RGRGRPRLLTPSP-TTDLHSGLQMRRARSPDL 232
>gi|238859651 pleckstrin homology domain containing family A member
4 isoform 1 [Homo sapiens]
Length = 779
Score = 66.6 bits (161), Expect = 7e-11
Identities = 61/212 (28%), Positives = 91/212 (42%), Gaps = 41/212 (19%)
Query: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLE---SGHDQ 457
GWL + + G + W+RRWFVL GH L++Y+ ++E G + + +Y++ G +
Sbjct: 59 GWLHKQDSSGLRL---WKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPR 115
Query: 458 KKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEA 517
+++ F H + ++ AADTL DL W+R L GRA S E
Sbjct: 116 GRRFTFTAEHPGMRTYVLAADTLEDLRGWLRAL----------GRA---------SRAEG 156
Query: 518 EDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGL 577
+D + SPA+ P G P P R G +++S E + R
Sbjct: 157 DD-------YGQPRSPARP-QPGEGPGGPGGPP--EVSRGEEGRISESPE-----VTRLS 201
Query: 578 RQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQL 609
R G L P P T + MRR R P L
Sbjct: 202 RGRGRPRLLTPSP-TTDLHSGLQMRRARSPDL 232
>gi|115527074 src kinase associated phosphoprotein 1 isoform 1 [Homo
sapiens]
Length = 359
Score = 57.0 bits (136), Expect = 6e-08
Identities = 55/238 (23%), Positives = 88/238 (36%), Gaps = 12/238 (5%)
Query: 358 AGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRW 417
+GT GL + D + + +G+ + +EL G+L + F G W
Sbjct: 73 SGTLGLSLTSDAPFLSDYQDEGMEDIVK----GAQELDNVIKQGYLEKKSKDHSFFGSEW 128
Query: 418 RRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESG----HDQKKKYVFQLTHDVYKPF 473
++RW V+ Y+Y + ++ +G + Y + D KK+ F+LT + +
Sbjct: 129 QKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSY 188
Query: 474 IFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSP 533
F A + + WV + + S P EED E + E DD G S S
Sbjct: 189 EFTATSPAEARDWVDQISFLLKDLSS---LTIPYEEDEEEEEKEETYDDIDGFDSPSCGS 245
Query: 534 AQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGGVSLLGQPQPL 591
+ L G PT+ + E LE G R+ GV Q L
Sbjct: 246 QCRPTILPGSVG-IKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGL 302
>gi|115527076 src kinase associated phosphoprotein 1 isoform 2 [Homo
sapiens]
Length = 358
Score = 55.1 bits (131), Expect = 2e-07
Identities = 52/228 (22%), Positives = 85/228 (37%), Gaps = 12/228 (5%)
Query: 358 AGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRW 417
+GT GL + D + + +G+ + +EL G+L + F G W
Sbjct: 73 SGTLGLSLTSDAPFLSDYQDEGMEDIVK----GAQELDNVIKQGYLEKKSKDHSFFGSEW 128
Query: 418 RRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESG----HDQKKKYVFQLTHDVYKPF 473
++RW V+ Y+Y + ++ +G + Y + D KK+ F+LT + +
Sbjct: 129 QKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSY 188
Query: 474 IFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSP 533
F A + + WV + + S P EED E + E DD G S S
Sbjct: 189 EFTATSPAEARDWVDQISFLLKDLSS---LTIPYEEDEEEEEKEETYDDIDGFDSPSCGS 245
Query: 534 AQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGG 581
+ L G PT+ + E LE G R+ G
Sbjct: 246 QCRPTILPGSVG-IKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKG 292
>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
Length = 398
Score = 54.7 bits (130), Expect = 3e-07
Identities = 26/69 (37%), Positives = 38/69 (55%), Gaps = 3/69 (4%)
Query: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456
PD +GWLL GG W+RRWF+L + LY++ D++ G+I + N S+ D
Sbjct: 261 PDREGWLLKL---GGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVED 317
Query: 457 QKKKYVFQL 465
KK F+L
Sbjct: 318 SKKPNCFEL 326
>gi|50980301 myosin phosphatase-Rho interacting protein isoform 2
[Homo sapiens]
Length = 1025
Score = 53.5 bits (127), Expect = 7e-07
Identities = 101/437 (23%), Positives = 166/437 (37%), Gaps = 55/437 (12%)
Query: 223 SQVDTQVPTDSRLQIQPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPET 282
S +Q P S L+ +PG E + E+ + R + R++ E SL K +
Sbjct: 224 SPSQSQPPAASSLR-EPGLESKE--EESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAE 280
Query: 283 PPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEP 342
Q PP L P +P+ + + + + D+ + + GPSP+ +D+ E
Sbjct: 281 EQQLPPP-LSPPSPSTPNHRRSQVIEKFEALDIEKAEHMETNAVGPSPS-SDTRQGRSEK 338
Query: 343 LPIPPE-------PPAILPAGVAGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELG 395
P + PPA LP A P SP +++K L R + V+
Sbjct: 339 RAFPRKRDFTNEAPPAPLPDASAS----PLSP------HRRAKSLDRRSTEPSVT----- 383
Query: 396 RPDC----DGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKA---EGLINVSN 448
PD GWL + G +W++ WFVL +L +YR E+A +G I++S
Sbjct: 384 -PDLLNFKKGWLTKQYEDG-----QWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSA 437
Query: 449 YSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPRE 508
+ + ++ Y FQ+ H F +A T W++ I K+ P AP
Sbjct: 438 CYDVTEYPVQRNYGFQI-HTKEGEFTLSAMTSGIRRNWIQ----TIMKHVHPTTAPD--- 489
Query: 509 EDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEE 568
+ + E+ + + S P P + G+ P ++ R G
Sbjct: 490 ---VTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWA 546
Query: 569 ALEGMVRGLRQ---GGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKA 625
+ + L Q GGV +PL E + R R + ER R L +T
Sbjct: 547 EFRPIQQALAQERVGGVGPADTHEPLRPEA-EPGELERERARRREERRKRFGMLDATDGP 605
Query: 626 KLQELQVLEEVLGDPEL 642
++ + EV P L
Sbjct: 606 GTEDAALRMEVDRSPGL 622
Score = 32.0 bits (71), Expect = 2.0
Identities = 49/206 (23%), Positives = 78/206 (37%), Gaps = 33/206 (16%)
Query: 396 RPDCDGWLLLRKAPGGFMGP-----RWRRRWFVLKGHTLYWYR--QPQDEKAEGLINVSN 448
+P GWLLL F P +W+RR+F+L H L Y + +G IN++
Sbjct: 43 KPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQ 102
Query: 449 YS---LESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLIT---CISKYQSPGR 502
+ G +K + LT + K A+T +S W+ L+ + Q R
Sbjct: 103 CTDVVDGEGRTGQKFSLCILTPE--KEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKR 160
Query: 503 --APPPREEDCYSETEAEDPDDEAGSHSASPSPAQA---------------GSPLHGDTS 545
PP +E ++ + S S+ PS + P S
Sbjct: 161 KVEPPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLS 220
Query: 546 PAATPTQRSPRTSFGSLTDSSEEALE 571
PA +P+Q P + SL + E+ E
Sbjct: 221 PAQSPSQSQPPAA-SSLREPGLESKE 245
>gi|50980307 myosin phosphatase-Rho interacting protein isoform 1
[Homo sapiens]
Length = 1038
Score = 53.5 bits (127), Expect = 7e-07
Identities = 101/437 (23%), Positives = 166/437 (37%), Gaps = 55/437 (12%)
Query: 223 SQVDTQVPTDSRLQIQPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPET 282
S +Q P S L+ +PG E + E+ + R + R++ E SL K +
Sbjct: 224 SPSQSQPPAASSLR-EPGLESKE--EESAMSSDRMDCGRKVRVESGYFSLEKTKQDLKAE 280
Query: 283 PPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEP 342
Q PP L P +P+ + + + + D+ + + GPSP+ +D+ E
Sbjct: 281 EQQLPPP-LSPPSPSTPNHRRSQVIEKFEALDIEKAEHMETNAVGPSPS-SDTRQGRSEK 338
Query: 343 LPIPPE-------PPAILPAGVAGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELG 395
P + PPA LP A P SP +++K L R + V+
Sbjct: 339 RAFPRKRDFTNEAPPAPLPDASAS----PLSP------HRRAKSLDRRSTEPSVT----- 383
Query: 396 RPDC----DGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKA---EGLINVSN 448
PD GWL + G +W++ WFVL +L +YR E+A +G I++S
Sbjct: 384 -PDLLNFKKGWLTKQYEDG-----QWKKHWFVLADQSLRYYRDSVAEEAADLDGEIDLSA 437
Query: 449 YSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPRE 508
+ + ++ Y FQ+ H F +A T W++ I K+ P AP
Sbjct: 438 CYDVTEYPVQRNYGFQI-HTKEGEFTLSAMTSGIRRNWIQ----TIMKHVHPTTAPD--- 489
Query: 509 EDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEE 568
+ + E+ + + S P P + G+ P ++ R G
Sbjct: 490 ---VTSSLPEEKNKSSCSFETCPRPTEKQEAELGEPDPEQKRSRARERRREGRSKTFDWA 546
Query: 569 ALEGMVRGLRQ---GGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKA 625
+ + L Q GGV +PL E + R R + ER R L +T
Sbjct: 547 EFRPIQQALAQERVGGVGPADTHEPLRPEA-EPGELERERARRREERRKRFGMLDATDGP 605
Query: 626 KLQELQVLEEVLGDPEL 642
++ + EV P L
Sbjct: 606 GTEDAALRMEVDRSPGL 622
Score = 32.0 bits (71), Expect = 2.0
Identities = 49/206 (23%), Positives = 78/206 (37%), Gaps = 33/206 (16%)
Query: 396 RPDCDGWLLLRKAPGGFMGP-----RWRRRWFVLKGHTLYWYR--QPQDEKAEGLINVSN 448
+P GWLLL F P +W+RR+F+L H L Y + +G IN++
Sbjct: 43 KPIYGGWLLLAPDGTDFDNPVHRSRKWQRRFFILYEHGLLRYALDEMPTTLPQGTINMNQ 102
Query: 449 YS---LESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLIT---CISKYQSPGR 502
+ G +K + LT + K A+T +S W+ L+ + Q R
Sbjct: 103 CTDVVDGEGRTGQKFSLCILTPE--KEHFIRAETKEIVSGWLEMLMVYPRTNKQNQKKKR 160
Query: 503 --APPPREEDCYSETEAEDPDDEAGSHSASPSPAQA---------------GSPLHGDTS 545
PP +E ++ + S S+ PS + P S
Sbjct: 161 KVEPPTPQEPGPAKVAVTSSSSSSSSSSSIPSAEKVPTTKSTLWQEEMRTKDQPDGSSLS 220
Query: 546 PAATPTQRSPRTSFGSLTDSSEEALE 571
PA +P+Q P + SL + E+ E
Sbjct: 221 PAQSPSQSQPPAA-SSLREPGLESKE 245
>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
Length = 400
Score = 52.8 bits (125), Expect = 1e-06
Identities = 25/69 (36%), Positives = 38/69 (55%), Gaps = 3/69 (4%)
Query: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456
PD +GWLL GG W+RRWF+L + LY++ D++ G+I + N S+ D
Sbjct: 260 PDREGWLLKL---GGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDD 316
Query: 457 QKKKYVFQL 465
+K F+L
Sbjct: 317 PRKPNCFEL 325
>gi|219689123 pleckstrin homology domain containing, family A member
5 isoform 2 [Homo sapiens]
Length = 1105
Score = 52.0 bits (123), Expect = 2e-06
Identities = 26/94 (27%), Positives = 49/94 (52%), Gaps = 6/94 (6%)
Query: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYS---LESGHDQ 457
GWL + + G + W++RWFVL L++YR ++E G I + ++ L S
Sbjct: 66 GWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHI 122
Query: 458 KKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLI 491
+KY F+ H + + F DT ++ +W++ ++
Sbjct: 123 NRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAML 156
>gi|19923493 pleckstrin homology domain containing, family A member
5 isoform 1 [Homo sapiens]
Length = 1116
Score = 52.0 bits (123), Expect = 2e-06
Identities = 26/94 (27%), Positives = 49/94 (52%), Gaps = 6/94 (6%)
Query: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYS---LESGHDQ 457
GWL + + G + W++RWFVL L++YR ++E G I + ++ L S
Sbjct: 174 GWLYKQDSTGMKL---WKKRWFVLSDLCLFYYRDEKEEGILGSILLPSFQIALLTSEDHI 230
Query: 458 KKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLI 491
+KY F+ H + + F DT ++ +W++ ++
Sbjct: 231 NRKYAFKAAHPNMRTYYFCTDTGKEMELWMKAML 264
>gi|4758968 cytohesin 3 [Homo sapiens]
Length = 399
Score = 52.0 bits (123), Expect = 2e-06
Identities = 26/81 (32%), Positives = 42/81 (51%), Gaps = 4/81 (4%)
Query: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456
PD +GWLL G W+RRWF+L + LY++ D++ G+I + N S+ D
Sbjct: 265 PDREGWLLKL----GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVED 320
Query: 457 QKKKYVFQLTHDVYKPFIFAA 477
+K F+L + +K + A
Sbjct: 321 PRKPNCFELYNPSHKGQVIKA 341
>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
Length = 397
Score = 52.0 bits (123), Expect = 2e-06
Identities = 25/69 (36%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456
PD +GWLL G W+RRWF+L + LY++ D++ G+I + N S+ D
Sbjct: 261 PDREGWLLKL----GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVED 316
Query: 457 QKKKYVFQL 465
KK F+L
Sbjct: 317 SKKPNCFEL 325
>gi|7019505 cytohesin 4 [Homo sapiens]
Length = 394
Score = 50.4 bits (119), Expect = 6e-06
Identities = 24/69 (34%), Positives = 38/69 (55%), Gaps = 4/69 (5%)
Query: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456
PD +GWLL G W+RRWF+L + LY++ D++ G+I + N S++ D
Sbjct: 260 PDREGWLLKL----GGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLENLSVQKVDD 315
Query: 457 QKKKYVFQL 465
KK + +L
Sbjct: 316 PKKPFCLEL 324
>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
Length = 399
Score = 50.1 bits (118), Expect = 7e-06
Identities = 24/69 (34%), Positives = 37/69 (53%), Gaps = 4/69 (5%)
Query: 397 PDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHD 456
PD +GWLL G W+RRWF+L + LY++ D++ G+I + N S+ D
Sbjct: 260 PDREGWLLKL----GGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDD 315
Query: 457 QKKKYVFQL 465
+K F+L
Sbjct: 316 PRKPNCFEL 324
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 855
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/105 (33%), Positives = 50/105 (47%), Gaps = 9/105 (8%)
Query: 271 SLVLKKIPIPETPPQTPP-QVLDSPHQRSPS-----LSLAPLSP--RAPSEDVFAFDLSS 322
+L L + P +PP +PP L +P ++P+ L AP SP P + F+ S
Sbjct: 399 ALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 458
Query: 323 NPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGTPGLPESP 367
SP +P SL PL +PP PPA P + TP P++P
Sbjct: 459 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP-PQAP 502
Score = 46.6 bits (109), Expect = 8e-05
Identities = 45/152 (29%), Positives = 58/152 (38%), Gaps = 19/152 (12%)
Query: 238 QPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQR 297
QP + +Q V PRK+ L P S + P Q PP + +PH
Sbjct: 271 QPKPKGLQALRPPQVTPPRKDAAPAL--GPLSSSPLATPSPSAALQSQAPPTLPATPHSS 328
Query: 298 SPSLSLA---PLSPRAPSEDVFAFDLSSNPSPGPSPAWTD--------------SASLGP 340
S + LA PL+P +PS L S P+ PS A T S L P
Sbjct: 329 SLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 388
Query: 341 EPLPIPPEPPAILPAGVAGTPGLPESPDKSPV 372
P P PPA+ + P P SP SP+
Sbjct: 389 LATPPPQAPPALALPPLQAPPSPPASPPLSPL 420
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/134 (30%), Positives = 59/134 (44%), Gaps = 16/134 (11%)
Query: 271 SLVLKKIPIPETPPQTPPQVLDS--PHQRSPSLSLAPLS-----PRAPSEDVFAFDLSSN 323
SL + +P +PP +PP + P Q P L+ PL P+AP + L +
Sbjct: 473 SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA-LATPPLQAL 531
Query: 324 PSP-----GPSPAWTDSASLGPEPL--PIPPEPPAILPAGVAGTPGLPESPDKSPVGRKK 376
PSP G +P ++ SASL PL P P PP + + P P SP R
Sbjct: 532 PSPPASFPGQAP-FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPP 590
Query: 377 SKGLATRLSRRRVS 390
+ G T +S R++
Sbjct: 591 TPGPDTSVSGPRLT 604
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 9/110 (8%)
Query: 271 SLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSP 330
+L + + P +PP +PP SP +S + P + A L PSP SP
Sbjct: 430 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 489
Query: 331 AWTDSAS---LGPEPLPIPP----EPPAILPAGVAGTP--GLPESPDKSP 371
+ SA+ P PL PP +PP P +A P LP P P
Sbjct: 490 PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 539
Score = 35.0 bits (79), Expect = 0.24
Identities = 31/103 (30%), Positives = 40/103 (38%), Gaps = 23/103 (22%)
Query: 267 PAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPL--SPRAPSEDVFAFDLSSNP 324
P S L P+ PPQ PP + Q PS +P +PR P P
Sbjct: 543 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP------------P 590
Query: 325 SPGPSPAWTDSASLGPE----PLPIPPEPPAILPAGVAGTPGL 363
+PGP D++ GP P PP PP+ P+ P L
Sbjct: 591 TPGP-----DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDL 628
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/105 (33%), Positives = 50/105 (47%), Gaps = 9/105 (8%)
Query: 271 SLVLKKIPIPETPPQTPP-QVLDSPHQRSPS-----LSLAPLSP--RAPSEDVFAFDLSS 322
+L L + P +PP +PP L +P ++P+ L AP SP P + F+ S
Sbjct: 360 ALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASP 419
Query: 323 NPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGTPGLPESP 367
SP +P SL PL +PP PPA P + TP P++P
Sbjct: 420 PVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP-PQAP 463
Score = 42.0 bits (97), Expect = 0.002
Identities = 41/134 (30%), Positives = 59/134 (44%), Gaps = 16/134 (11%)
Query: 271 SLVLKKIPIPETPPQTPPQVLDS--PHQRSPSLSLAPLS-----PRAPSEDVFAFDLSSN 323
SL + +P +PP +PP + P Q P L+ PL P+AP + L +
Sbjct: 434 SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPA-LATPPLQAL 492
Query: 324 PSP-----GPSPAWTDSASLGPEPL--PIPPEPPAILPAGVAGTPGLPESPDKSPVGRKK 376
PSP G +P ++ SASL PL P P PP + + P P SP R
Sbjct: 493 PSPPASFPGQAP-FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPP 551
Query: 377 SKGLATRLSRRRVS 390
+ G T +S R++
Sbjct: 552 TPGPDTSVSGPRLT 565
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/110 (30%), Positives = 45/110 (40%), Gaps = 9/110 (8%)
Query: 271 SLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSP 330
+L + + P +PP +PP SP +S + P + A L PSP SP
Sbjct: 391 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 450
Query: 331 AWTDSAS---LGPEPLPIPP----EPPAILPAGVAGTP--GLPESPDKSP 371
+ SA+ P PL PP +PP P +A P LP P P
Sbjct: 451 PMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP 500
Score = 40.8 bits (94), Expect = 0.004
Identities = 35/121 (28%), Positives = 46/121 (38%), Gaps = 17/121 (14%)
Query: 266 EPAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPS 325
+P GL + P TPP+ P SP + +P +P +PS L S P+
Sbjct: 264 KPKGLQALR---PPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPA 320
Query: 326 PGPSPAWTD--------------SASLGPEPLPIPPEPPAILPAGVAGTPGLPESPDKSP 371
PS A T S L P P P PPA+ + P P SP SP
Sbjct: 321 TPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSP 380
Query: 372 V 372
+
Sbjct: 381 L 381
Score = 38.9 bits (89), Expect = 0.017
Identities = 43/138 (31%), Positives = 52/138 (37%), Gaps = 16/138 (11%)
Query: 238 QPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPP--QVLDSPH 295
QP + +Q V PRK+ L P S + P P PP Q L SP
Sbjct: 262 QPKPKGLQALRPPQVTPPRKDAAPAL--GPLSSSPLATPSPSAPPSPSAPPSLQTLPSPP 319
Query: 296 QRSPSLSLAPL-SPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPE----PLPIPPEPP 350
PS + L SP + F PSP SP T P PL PP PP
Sbjct: 320 ATPPSQATTSLGSPTLQATHSFL------PSPPLSPLATPPPQAPPALALPPLQAPPSPP 373
Query: 351 AILPAGVAGTPGLPESPD 368
A P TP P++P+
Sbjct: 374 ASPPLSPLATPS-PQAPN 390
Score = 35.0 bits (79), Expect = 0.24
Identities = 31/103 (30%), Positives = 40/103 (38%), Gaps = 23/103 (22%)
Query: 267 PAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPL--SPRAPSEDVFAFDLSSNP 324
P S L P+ PPQ PP + Q PS +P +PR P P
Sbjct: 504 PFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRP------------P 551
Query: 325 SPGPSPAWTDSASLGPE----PLPIPPEPPAILPAGVAGTPGL 363
+PGP D++ GP P PP PP+ P+ P L
Sbjct: 552 TPGP-----DTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDL 589
>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
containing 2 [Homo sapiens]
Length = 1455
Score = 48.5 bits (114), Expect = 2e-05
Identities = 37/139 (26%), Positives = 63/139 (45%), Gaps = 22/139 (15%)
Query: 211 EIHTTSNCQHFVSQVDTQVPTDSRLQIQPGDEVVQINEQVVVGWPRKNMVRELLREPAGL 270
E +T H + ++ P D +++ GD ++ +N Q ++ P ++V+ L + AGL
Sbjct: 943 ESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVK--LIKDAGL 1000
Query: 271 SLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSP 330
S+ L+ IP E P S ++SP +PL+ ++P PSP
Sbjct: 1001 SVTLRIIPQEEL---NSPTSAPSSEKQSPMAQQSPLAQQSPLAQ-------------PSP 1044
Query: 331 AWTDSASLGPEPLPIPPEP 349
A +S P P PP+P
Sbjct: 1045 ATPNS----PIAQPAPPQP 1059
>gi|16753212 src kinase associated phosphoprotein 2 [Homo sapiens]
Length = 359
Score = 47.8 bits (112), Expect = 4e-05
Identities = 33/144 (22%), Positives = 59/144 (40%), Gaps = 18/144 (12%)
Query: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGH----D 456
G+L R+ F+G W++RW L Y+Y +D++ +G + YS+ + D
Sbjct: 121 GYLEKRRKDHSFLGFEWQKRWCALSKTVFYYYGSDKDKQQKGEFAIDGYSVRMNNTLRKD 180
Query: 457 QKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETE 516
KK F+++ + + F A + D WV+ L + +D S+
Sbjct: 181 GKKDCCFEISAPDKRIYQFTAASPKDAEEWVQQLKFVL--------------QDMESDII 226
Query: 517 AEDPDDEAGSHSASPSPAQAGSPL 540
ED D+ + P +PL
Sbjct: 227 PEDYDERGELYDDVDHPLPISNPL 250
>gi|239047795 pleckstrin homology domain containing, family A member
7 [Homo sapiens]
Length = 1121
Score = 47.4 bits (111), Expect = 5e-05
Identities = 30/110 (27%), Positives = 52/110 (47%), Gaps = 25/110 (22%)
Query: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHDQ--- 457
GWL + + G + W+RRWFVL + L++Y+ ++E G I + +Y + +
Sbjct: 169 GWLHKQDSSGMRL---WKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRI 225
Query: 458 KKKYVFQLTHD-----VY--------------KPFIFAADTLTDLSMWVR 488
+KY F+ H +Y + + F+ADT D++ WVR
Sbjct: 226 SRKYSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVR 275
>gi|47132519 Ras association and pleckstrin homology domains 1
isoform 1 [Homo sapiens]
Length = 1250
Score = 47.4 bits (111), Expect = 5e-05
Identities = 38/111 (34%), Positives = 47/111 (42%), Gaps = 18/111 (16%)
Query: 267 PAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSL-APLSPRAPSEDVFAFDLSSNPS 325
PA S LK +P PQ+PP V P + S+ + +P P P E F P
Sbjct: 876 PAMESQPLKPVPA-NVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSLVF-----PP 929
Query: 326 PGPSPAWTDSASLGPEPLPIPPEPPAILPA-GVAGTPGLPESPDKSPVGRK 375
P PSP P P PP PP P +G+PG S SP G+K
Sbjct: 930 PPPSPV----------PAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKK 970
Score = 36.2 bits (82), Expect = 0.11
Identities = 34/97 (35%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 278 PIPETPP-QTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSA 336
P P TPP PP L P Q+S + P SP +P V S P P P+P +S
Sbjct: 826 PSPPTPPVPVPPPTL--PKQQS-FCAKPPPSPLSPVPSVVKQIASQFPPP-PTPPAMESQ 881
Query: 337 SLGPEPLPIPPEPPAILPAGVAGTP-GLP-ESPDKSP 371
L P P + P+ P + A P +P SPD P
Sbjct: 882 PLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPP 918
Score = 33.1 bits (74), Expect = 0.92
Identities = 29/97 (29%), Positives = 36/97 (37%), Gaps = 27/97 (27%)
Query: 280 PETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLG 339
P TPP PP APL P+AP + L + P+P + +
Sbjct: 760 PPTPPPPPP-------------IPAPLPPQAPPK-----PLVTIPAPTSTKTVAPVVTQA 801
Query: 340 PEPLPIPPEPPA----ILPAGVAGTPGLPESPDKSPV 372
P P PP PPA PA +P SP PV
Sbjct: 802 APPTPTPPVPPAKKQPAFPASY-----IPPSPPTPPV 833
Score = 31.2 bits (69), Expect = 3.5
Identities = 20/58 (34%), Positives = 24/58 (41%), Gaps = 7/58 (12%)
Query: 305 PLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGTPG 362
PLSP+ + S P P P P P P P PP PP LP+ A + G
Sbjct: 608 PLSPQPKIVTPYTASQPSPPLPPPPPP-------PPPPPPPPPPPPPPLPSQSAPSAG 658
>gi|24308073 protein tyrosine phosphatase, non-receptor type 23 [Homo
sapiens]
Length = 1636
Score = 47.0 bits (110), Expect = 6e-05
Identities = 43/125 (34%), Positives = 49/125 (39%), Gaps = 14/125 (11%)
Query: 278 PIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPG--PSPAWTDS 335
P P PP P +P R APL+ R PS S PSP PSPA
Sbjct: 1039 PGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAG-----QSTPSPHLVPSPA---- 1089
Query: 336 ASLGPEPLPIPP---EPPAILPAGVAGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCR 392
S GP P+P P EPP L G A L SP+ G + G L +V
Sbjct: 1090 PSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPLLQPTKVDAA 1149
Query: 393 ELGRP 397
E RP
Sbjct: 1150 EGRRP 1154
Score = 32.3 bits (72), Expect = 1.6
Identities = 30/112 (26%), Positives = 42/112 (37%), Gaps = 19/112 (16%)
Query: 229 VPTDSRLQIQPGDEVVQINEQVVVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPP 288
+P DS+ + GD V + + + + +R P GL + +P P PP PP
Sbjct: 1480 LPQDSQDLVLGGD--------VPISSIQATIAKLSIRPPGGLESPVASLPGPAEPPGLPP 1531
Query: 289 QVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGP 340
L PS S PLS P P P P ++ S GP
Sbjct: 1532 ASLPE-STPIPSSSPPPLSSPLPEA----------PQPKEEPPVPEAPSSGP 1572
Score = 31.6 bits (70), Expect = 2.7
Identities = 27/95 (28%), Positives = 39/95 (41%), Gaps = 19/95 (20%)
Query: 277 IPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSA 336
+P P T P Q + + H S + +PR + P P P P S
Sbjct: 918 LPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPR----------IGPQPQPHPQP--HPSQ 965
Query: 337 SLGPEP--LPIPPEPPAILPAGVAGTPGL--PESP 367
+ GP+P P+P + P + P PGL P+SP
Sbjct: 966 AFGPQPPQQPLPLQHPHLFP---PQAPGLLPPQSP 997
Score = 31.2 bits (69), Expect = 3.5
Identities = 22/79 (27%), Positives = 31/79 (39%), Gaps = 7/79 (8%)
Query: 278 PIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSAS 337
P+ P PPQ P L++A + P + D + S+ +P P+P
Sbjct: 856 PVAGLPSAPPPQF------SGPELAMA-VRPATTTVDSIQAPIPSHTAPRPNPTPAPPPP 908
Query: 338 LGPEPLPIPPEPPAILPAG 356
P P P P P PAG
Sbjct: 909 CFPVPPPQPLPTPYTYPAG 927
>gi|37595548 phosphoinositol 3-phosphate-binding protein-3 [Homo
sapiens]
Length = 1048
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/141 (20%), Positives = 62/141 (43%), Gaps = 11/141 (7%)
Query: 401 GWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNY---SLESGHDQ 457
GWL + + G +W +RWFVL L++Y+ ++E G I + ++ +++ +
Sbjct: 64 GWLFKQASSGV---KQWNKRWFVLVDRCLFYYKDEKEESILGSIPLLSFRVAAVQPSDNI 120
Query: 458 KKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPR-----EEDCY 512
+K+ F+ H + + F+A++ + W++ + P + P+ E
Sbjct: 121 SRKHTFKAEHAGVRTYFFSAESPEEQEAWIQAMGEAARVQIPPAQKSVPQAVRHSHEKPD 180
Query: 513 SETEAEDPDDEAGSHSASPSP 533
SE + H++ P P
Sbjct: 181 SENVPPSKHHQQPPHNSLPKP 201
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/99 (30%), Positives = 43/99 (43%), Gaps = 8/99 (8%)
Query: 271 SLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSP 330
+L + + P +PP +PP SP +S + P + A L PSP SP
Sbjct: 655 ALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASP 714
Query: 331 AWTDSASLGPE--------PLPIPPEPPAILPAGVAGTP 361
+ SA+ P+ PL +PP PPA P + TP
Sbjct: 715 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATP 753
Score = 45.4 bits (106), Expect = 2e-04
Identities = 38/125 (30%), Positives = 50/125 (40%), Gaps = 25/125 (20%)
Query: 272 LVLKKIPIPETPPQTPP-QVLDSPHQRSPS-----LSLAPLSP--RAPSEDVFAFDLSSN 323
L L + P +PP +PP L +P ++P+ L AP SP P + F+ S
Sbjct: 625 LALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPP 684
Query: 324 PSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGTP-----------------GLPES 366
SP +P SL PL +PP PPA P + TP P S
Sbjct: 685 VSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPAS 744
Query: 367 PDKSP 371
P SP
Sbjct: 745 PPMSP 749
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/106 (31%), Positives = 41/106 (38%), Gaps = 19/106 (17%)
Query: 267 PAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSP 326
PA L P+ PP+TP + P Q P+L+ P L PSP
Sbjct: 564 PAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPP--------------LQGLPSP 609
Query: 327 GPSPAWTDSASLGP----EPLPIPPEPPAILPAGVAGTPGLPESPD 368
SP T P PL PP PPA P TP P++P+
Sbjct: 610 PLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPS-PQAPN 654
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/105 (32%), Positives = 46/105 (43%), Gaps = 21/105 (20%)
Query: 271 SLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSP 330
SL + +P +PP +PP SPS + P +P + A L PSP SP
Sbjct: 698 SLAAPPLQVPPSPPASPPM--------SPSATPPPQAP----PPLAAPPLQVPPSPPASP 745
Query: 331 AWTDSAS--------LGPEPLPIPPEPPAILPAGVAGTPGLPESP 367
+ SA+ L PL +PP PPA LP P P++P
Sbjct: 746 PMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPP-PQAP 789
Score = 41.6 bits (96), Expect = 0.003
Identities = 33/116 (28%), Positives = 45/116 (38%), Gaps = 27/116 (23%)
Query: 278 PIPETPPQTPPQVLDSPHQRSPS----------LSLAPLSPRA----------------P 311
P+ PPQ PP + P Q PS + +P +P A P
Sbjct: 613 PLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPP 672
Query: 312 SEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGTPGLPESP 367
+ F+ S SP +P SL PL +PP PPA P + TP P++P
Sbjct: 673 VQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPP-PQAP 727
Score = 40.8 bits (94), Expect = 0.004
Identities = 40/146 (27%), Positives = 53/146 (36%), Gaps = 15/146 (10%)
Query: 264 LREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQR--SPSLSLAPLSPRAPSEDVFAFDLS 321
L+ P L P+ + PPQ PP + P Q SP S +P +PS + L+
Sbjct: 766 LQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLA 825
Query: 322 SNPSPGPSPAWTDSASLGPEP-----LPIPPEPPAILP-AGVAG-------TPGLPESPD 368
+ P P + P P L P PP P V+G PG P P
Sbjct: 826 TPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPS 885
Query: 369 KSPVGRKKSKGLATRLSRRRVSCREL 394
+SP LA S + EL
Sbjct: 886 RSPSSTLSGPDLAGHSSSATSTPEEL 911
Score = 39.7 bits (91), Expect = 0.010
Identities = 42/134 (31%), Positives = 55/134 (41%), Gaps = 12/134 (8%)
Query: 267 PAGLSLVLKKIPIPETPP---QTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSN 323
PA + P P PP P QV SP P LA P+AP + L +
Sbjct: 742 PASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPA-LATPPLQAL 800
Query: 324 PS-----PGPSPAWTDSASLGPEPLPIPP--EPPAILPAGVAGTPGLPESPDKSPVGRKK 376
PS PG +P ++ SASL PL PP PP + + P P SP R
Sbjct: 801 PSPPASFPGQAP-FSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPP 859
Query: 377 SKGLATRLSRRRVS 390
+ G T +S R++
Sbjct: 860 TPGPDTSVSGPRLT 873
Score = 36.2 bits (82), Expect = 0.11
Identities = 37/125 (29%), Positives = 51/125 (40%), Gaps = 23/125 (18%)
Query: 264 LREPAGLSLVLKKIPIPETPPQTPPQVLDSP----HQRSPS----LSLAPLSPRAPSEDV 315
L+ PA SL P+ +P ++ P +P H P +L P P +D
Sbjct: 234 LQRPASRSLSSSATPL-SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDA 292
Query: 316 FAF--DLSSNPSPGPSPAWTDSASLGP-----EPLP--IPPEPPAILPAGVAGTPGLPES 366
LSS+P PSP+ T + + P PLP +PP PP P +A P S
Sbjct: 293 APALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLA-----PPS 347
Query: 367 PDKSP 371
P P
Sbjct: 348 PSAPP 352
Score = 35.8 bits (81), Expect = 0.14
Identities = 31/94 (32%), Positives = 41/94 (43%), Gaps = 19/94 (20%)
Query: 278 PIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSAS 337
P+P T P +PP L +P L LAP SP AP L + PSP +P S
Sbjct: 326 PLPATLPPSPP--LATP------LPLAPPSPSAPPS------LQTLPSPPATPPSQAPPS 371
Query: 338 LGPEPLPIPPE----PPAILPAGVAGTPGLPESP 367
+ P+ PP PP +P + +P L P
Sbjct: 372 MTTPPMQAPPSLQTIPPIQVPHSLT-SPSLQAPP 404
Score = 35.8 bits (81), Expect = 0.14
Identities = 33/99 (33%), Positives = 41/99 (41%), Gaps = 18/99 (18%)
Query: 284 PQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASL----- 338
PQ P L P + S SLAP S + P + L + PS P P T SA L
Sbjct: 500 PQAPLSSLIMPPLETQS-SLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHL 558
Query: 339 ------GPEPLPIPPE----PPAILPAGVAGTPGLPESP 367
P PL PP PP P+ +A P P++P
Sbjct: 559 ETPPCPAPCPLQAPPSPLTTPPPETPSSIATPP--PQAP 595
Score = 34.3 bits (77), Expect = 0.41
Identities = 34/103 (33%), Positives = 41/103 (39%), Gaps = 12/103 (11%)
Query: 278 PIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSED--------VFAFDLSSNPSPGPS 329
P PPQ PP + P Q PS +P P +PS + A L PSP S
Sbjct: 718 PSATPPPQAPPPLAAPPLQVPPSPPASP--PMSPSATPPPRVPPLLAAPPLQVPPSPPAS 775
Query: 330 PAWTDSASLGPEPLPIPPEPP-AILPAGVAGTPG-LPESPDKS 370
+ A P+ P PP LP+ A PG P SP S
Sbjct: 776 LPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSAS 818
Score = 32.0 bits (71), Expect = 2.0
Identities = 33/106 (31%), Positives = 41/106 (38%), Gaps = 11/106 (10%)
Query: 277 IPIPETPP---QTPPQV--LDSP---HQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGP 328
+ +P +PP P V L SP H SLA SP+AP + L + S P
Sbjct: 461 LSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAP 520
Query: 329 SPAWTDSASLGPEP---LPIPPEPPAILPAGVAGTPGLPESPDKSP 371
T ASL P LP PP + TP L P +P
Sbjct: 521 PSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAP 566
>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
Length = 1263
Score = 44.7 bits (104), Expect = 3e-04
Identities = 58/238 (24%), Positives = 102/238 (42%), Gaps = 22/238 (9%)
Query: 138 NDFSACQEIRDLLEE-LSQ-VLHEDGPAAEKEGTVLRICSHVAGICHNILVCCPKELLEQ 195
ND+ A + L+EE +SQ VLH++G + + L+I + G+ ++ E E
Sbjct: 413 NDYEARPQYYKLIEECISQIVLHKNGADPDFKCRHLQI--EIEGLIDQMIDKTKVEKSEA 470
Query: 196 KAVLEQVQLDSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPGDEVVQINEQVVVGWP 255
KA + +LDS L T+ + V + + +LQ G++ +E+ +
Sbjct: 471 KAAELEKKLDSEL------TARHELQVEMKKMESDFEQKLQDLQGEKDALHSEKQQIATE 524
Query: 256 RKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDV 315
++++ E+ + ++ + K++ + + + PS + P +P P +
Sbjct: 525 KQDLEAEVSQLTGEVAKLTKELEDAKKEMASLSAAAITVPPSVPSRAPVPPAPPLPGD-- 582
Query: 316 FAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGV--AGTPGLPESPDKSP 371
S P PA DS + P P P PP PP LP GV + P LP SP
Sbjct: 583 ------SGTIIPPPPAPGDSTTPPPPPPPPPPPPP--LPGGVCISSPPSLPGGTAISP 632
Score = 32.3 bits (72), Expect = 1.6
Identities = 26/95 (27%), Positives = 33/95 (34%), Gaps = 9/95 (9%)
Query: 279 IPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPG------PSPAW 332
IP PP + SP ++ P P S + P PG P P
Sbjct: 642 IPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARI---PPPPPPLPGSAGIPPPPPPL 698
Query: 333 TDSASLGPEPLPIPPEPPAILPAGVAGTPGLPESP 367
A + P P P+P P P G PG+P P
Sbjct: 699 PGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPP 733
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,264,194
Number of Sequences: 37866
Number of extensions: 2032321
Number of successful extensions: 14637
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 140
Number of HSP's successfully gapped in prelim test: 761
Number of HSP's that attempted gapping in prelim test: 10709
Number of HSP's gapped (non-prelim): 3848
length of query: 713
length of database: 18,247,518
effective HSP length: 109
effective length of query: 604
effective length of database: 14,120,124
effective search space: 8528554896
effective search space used: 8528554896
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.