Search of human proteins with 187960069

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|187960069 glutamate receptor, metabotropic 8 isoform b
precursor [Homo sapiens]
         (908 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|187960069 glutamate receptor, metabotropic 8 isoform b precur...  1841   0.0  
gi|187960067 glutamate receptor, metabotropic 8 isoform a precur...  1814   0.0  
gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]         1392   0.0  
gi|4504147 glutamate receptor, metabotropic 7 isoform a precurso...  1379   0.0  
gi|32528268 glutamate receptor, metabotropic 7 isoform b precurs...  1378   0.0  
gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo ...  1251   0.0  
gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo s...   746   0.0  
gi|66529100 glutamate receptor, metabotropic 2 isoform a precurs...   714   0.0  
gi|219842343 glutamate receptor, metabotropic 5 isoform a precur...   654   0.0  
gi|4504143 glutamate receptor, metabotropic 5 isoform b precurso...   654   0.0  
gi|166999223 glutamate receptor, metabotropic 1 isoform beta pre...   642   0.0  
gi|166999098 glutamate receptor, metabotropic 1 isoform alpha pr...   642   0.0  
gi|37577159 calcium-sensing receptor [Homo sapiens]                   402   e-112
gi|112807234 G protein-coupled receptor, family C, group 6, memb...   249   8e-66
gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]          219   7e-57
gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]         218   2e-56
gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo ...   213   8e-55
gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]           201   3e-51
gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]         117   5e-26
gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]         114   4e-25
gi|40255245 G protein-coupled receptor 51 [Homo sapiens]               69   3e-11
gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform...    60   1e-08
gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...    60   1e-08
gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform ...    60   1e-08
gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]     51   6e-06
gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]     51   6e-06
gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]     51   6e-06
gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]          50   1e-05
gi|7706451 G protein-coupled receptor, family C, group 5, member...    48   4e-05
gi|93204867 G protein-coupled receptor 158 [Homo sapiens]              43   0.001

>gi|187960069 glutamate receptor, metabotropic 8 isoform b precursor
           [Homo sapiens]
          Length = 908

 Score = 1841 bits (4769), Expect = 0.0
 Identities = 908/908 (100%), Positives = 908/908 (100%)

Query: 1   MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER 60
           MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
Sbjct: 1   MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER 60

Query: 61  GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120
           GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
Sbjct: 61  GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120

Query: 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA 180
           QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
Sbjct: 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA 180

Query: 181 PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR 240
           PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
Sbjct: 181 PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR 240

Query: 241 EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS 300
           EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
Sbjct: 241 EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS 300

Query: 301 GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360
           GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
Sbjct: 301 GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360

Query: 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH 420
           EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
Sbjct: 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH 420

Query: 421 KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN 480
           KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
Sbjct: 421 KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN 480

Query: 481 KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER 540
           KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
Sbjct: 481 KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER 540

Query: 541 CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF 600
           CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
Sbjct: 541 CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF 600

Query: 601 VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC 660
           VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
Sbjct: 601 VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC 660

Query: 661 FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH 720
           FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
Sbjct: 661 FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH 720

Query: 721 IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA 780
           IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
Sbjct: 721 IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA 780

Query: 781 KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI 840
           KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
Sbjct: 781 KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI 840

Query: 841 IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNSKSSVEFP 900
           IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNSKSSVEFP
Sbjct: 841 IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNSKSSVEFP 900

Query: 901 MVKSGSTS 908
           MVKSGSTS
Sbjct: 901 MVKSGSTS 908


>gi|187960067 glutamate receptor, metabotropic 8 isoform a precursor
           [Homo sapiens]
          Length = 908

 Score = 1814 bits (4699), Expect = 0.0
 Identities = 893/896 (99%), Positives = 895/896 (99%)

Query: 1   MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER 60
           MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
Sbjct: 1   MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER 60

Query: 61  GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120
           GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
Sbjct: 61  GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV 120

Query: 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA 180
           QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
Sbjct: 121 QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA 180

Query: 181 PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR 240
           PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
Sbjct: 181 PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR 240

Query: 241 EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS 300
           EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
Sbjct: 241 EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS 300

Query: 301 GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360
           GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
Sbjct: 301 GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360

Query: 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH 420
           EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
Sbjct: 361 EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH 420

Query: 421 KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN 480
           KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
Sbjct: 421 KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN 480

Query: 481 KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER 540
           KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
Sbjct: 481 KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER 540

Query: 541 CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF 600
           CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
Sbjct: 541 CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF 600

Query: 601 VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC 660
           VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
Sbjct: 601 VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC 660

Query: 661 FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH 720
           FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
Sbjct: 661 FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH 720

Query: 721 IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA 780
           IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
Sbjct: 721 IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA 780

Query: 781 KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI 840
           KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
Sbjct: 781 KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI 840

Query: 841 IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNSKSS 896
           IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETN+ S+
Sbjct: 841 IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSST 896


>gi|4504141 glutamate receptor, metabotropic 4 [Homo sapiens]
          Length = 912

 Score = 1392 bits (3604), Expect = 0.0
 Identities = 671/883 (75%), Positives = 761/883 (86%), Gaps = 1/883 (0%)

Query: 9   ASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK 68
           A  P   LL+    W+ + + +     + +SIR+DGDI LGGLFPVH +G  G PCGELK
Sbjct: 12  ARLPLCLLLSLYGPWMPSSLGKPKGHPHMNSIRIDGDITLGGLFPVHGRGSEGKPCGELK 71

Query: 69  KEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDA 128
           KEKGIHRLEAML+A+D+IN DPDLL NITLG RILDTCSRDT+ALEQSLTFVQALIEKD 
Sbjct: 72  KEKGIHRLEAMLFALDRINNDPDLLPNITLGARILDTCSRDTHALEQSLTFVQALIEKDG 131

Query: 129 SDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTR 188
           ++V+C +G PPI TKP+++ GVIGA+ SSVSIMVANILRLFKIPQISYASTAP+LSDN+R
Sbjct: 132 TEVRCGSGGPPIITKPERVVGVIGASGSSVSIMVANILRLFKIPQISYASTAPDLSDNSR 191

Query: 189 YDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIA 248
           YDFFSRVVP D+YQAQAMVDIV AL WNYVST+ASEG+YGESGVEAF Q SRE GGVCIA
Sbjct: 192 YDFFSRVVPSDTYQAQAMVDIVRALKWNYVSTVASEGSYGESGVEAFIQKSREDGGVCIA 251

Query: 249 QSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGS 308
           QS KIPREP+ GEF+KII+RLLET NARAVI+FANEDDIRR+LEAA++ NQ+GHF W+GS
Sbjct: 252 QSVKIPREPKAGEFDKIIRRLLETSNARAVIIFANEDDIRRVLEAARRANQTGHFFWMGS 311

Query: 309 DSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFG 368
           DSWGSKIAPV   EE+AEGAVTILPKR S+ GFDRYF SRTL NNRRN+WFAEFWE+NF 
Sbjct: 312 DSWGSKIAPVLHLEEVAEGAVTILPKRMSVRGFDRYFSSRTLDNNRRNIWFAEFWEDNFH 371

Query: 369 CKLGSHG-KRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGY 427
           CKL  H  K+ SH+KKCT  ERI +DS+YEQEGKVQFVIDAVY+M +ALH MH+DLCPG 
Sbjct: 372 CKLSRHALKKGSHVKKCTNRERIGQDSAYEQEGKVQFVIDAVYAMGHALHAMHRDLCPGR 431

Query: 428 IGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKV 487
           +GLCPRM  +DG +LL YIR VNF+G AG PVTFNENGDAPGRYDI+QYQ+ N S EYKV
Sbjct: 432 VGLCPRMDPVDGTQLLKYIRNVNFSGIAGNPVTFNENGDAPGRYDIYQYQLRNDSAEYKV 491

Query: 488 IGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQ 547
           IG WT+ LHL++E M W       P S+CSLPC+PGERKKTVKG+PCCWHCE C GY YQ
Sbjct: 492 IGSWTDHLHLRIERMHWPGSGQQLPRSICSLPCQPGERKKTVKGMPCCWHCEPCTGYQYQ 551

Query: 548 VDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVR 607
           VD  +C+ CP D RP  NRTGC+ IPIIKLEW SPWAV+P+F+A++GI AT FV++TFVR
Sbjct: 552 VDRYTCKTCPYDMRPTENRTGCRPIPIIKLEWGSPWAVLPLFLAVVGIAATLFVVITFVR 611

Query: 608 YNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALL 667
           YNDTPIV+ASGRELSYVLL GIFLCY+ TFLMIA PD   CS RR+FLGLGM  SYAALL
Sbjct: 612 YNDTPIVKASGRELSYVLLAGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALL 671

Query: 668 TKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGE 727
           TKTNRI+RIFEQGK+SV+AP+FISPASQL ITFSLIS+QLLG+ VWFVVDP H ++D+ +
Sbjct: 672 TKTNRIYRIFEQGKRSVSAPRFISPASQLAITFSLISLQLLGICVWFVVDPSHSVVDFQD 731

Query: 728 QRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTM 787
           QRTLDP  ARGVLKCDISDLSLIC LGYS+LLMVTCTVYAIKTRGVPETFNEAKPIGFTM
Sbjct: 732 QRTLDPRFARGVLKCDISDLSLICLLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTM 791

Query: 788 YTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQ 847
           YTTCI+WLAFIPIFFGT+QSA+K+YIQTTTLTVS+SLSASVSLGMLYMPKVYII+FHPEQ
Sbjct: 792 YTTCIVWLAFIPIFFGTSQSADKLYIQTTTLTVSVSLSASVSLGMLYMPKVYIILFHPEQ 851

Query: 848 NVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLE 890
           NV KRKRS KAVVTAATM +K  QKGN RPNGE KSELCE+LE
Sbjct: 852 NVPKRKRSLKAVVTAATMSNKFTQKGNFRPNGEAKSELCENLE 894


>gi|4504147 glutamate receptor, metabotropic 7 isoform a precursor
           [Homo sapiens]
          Length = 915

 Score = 1379 bits (3570), Expect = 0.0
 Identities = 662/863 (76%), Positives = 761/863 (88%), Gaps = 4/863 (0%)

Query: 38  HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNIT 97
           HSIR++GD+ LGGLFPVHAKG  GVPCG++K+E GIHRLEAMLYA+DQIN DP+LL N+T
Sbjct: 41  HSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVT 100

Query: 98  LGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS 157
           LG RILDTCSRDTYALEQSLTFVQALI+KD SDV+C NG+PP+F KP+K+ GVIGA+ SS
Sbjct: 101 LGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSS 160

Query: 158 VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNY 217
           VSIMVANILRLF+IPQISYASTAPELSD+ RYDFFSRVVPPDS+QAQAMVDIV ALGWNY
Sbjct: 161 VSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNY 220

Query: 218 VSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNA 275
           VSTLASEG+YGE GVE+FTQIS+E GG+CIAQS +IP+E   R  +F++IIK+LL+TPN+
Sbjct: 221 VSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNS 280

Query: 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKR 335
           RAV++FAN++DI++IL AAK+ +Q GHFLW+GSDSWGSKI P++Q E+IAEGA+TI PKR
Sbjct: 281 RAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKR 340

Query: 336 ASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHG-KRNSHIKKCTGLERIARDS 394
           A+++GFD YF SRTL NNRRNVWFAE+WEENF CKL   G K+    +KCTG ERI +DS
Sbjct: 341 ATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDS 400

Query: 395 SYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGS 454
           +YEQEGKVQFVIDAVY+MA+ALH+M+KDLC  Y G+CP M    GK+LL YIR VNFNGS
Sbjct: 401 NYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGS 460

Query: 455 AGTPVTFNENGDAPGRYDIFQYQITNKSTE-YKVIGHWTNQLHLKVEDMQWAHREHTHPA 513
           AGTPV FN+NGDAPGRYDIFQYQ TN S   Y++IG WT++L L +EDMQW       PA
Sbjct: 461 AGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPA 520

Query: 514 SVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIP 573
           SVC+LPCKPG+RKKT KG PCCW CE C+GY YQ DE++C+ CP DQRPN NRTGCQ IP
Sbjct: 521 SVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIP 580

Query: 574 IIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCY 633
           IIKLEWHSPWAV+PVF+A+LGIIAT FV+ TF+RYNDTPIVRASGRELSYVLLTGIFLCY
Sbjct: 581 IIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCY 640

Query: 634 SITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPA 693
            ITFLMIA PD  +CSFRRVFLGLGMC SYAALLTKTNRI+RIFEQGKKSVTAP+ ISP 
Sbjct: 641 IITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPT 700

Query: 694 SQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSL 753
           SQL IT SLISVQLLGVF+WF VDPP+IIIDY E +T++PE+ARGVLKCDI+DL +ICSL
Sbjct: 701 SQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSL 760

Query: 754 GYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813
           GYSILLMVTCTVYAIKTRGVPE FNEAKPIGFTMYTTCI+WLAFIPIFFGTAQSAEK+YI
Sbjct: 761 GYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYI 820

Query: 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKG 873
           QTTTLT+SM+LSASV+LGMLYMPKVYIIIFHPE NVQKRKRSFKAVVTAATM S+L  K 
Sbjct: 821 QTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKP 880

Query: 874 NDRPNGEVKSELCESLETNSKSS 896
           +DRPNGE K+ELCE+++ NS ++
Sbjct: 881 SDRPNGEAKTELCENVDPNSPAA 903


>gi|32528268 glutamate receptor, metabotropic 7 isoform b precursor
           [Homo sapiens]
          Length = 922

 Score = 1378 bits (3566), Expect = 0.0
 Identities = 661/860 (76%), Positives = 759/860 (88%), Gaps = 4/860 (0%)

Query: 38  HSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNIT 97
           HSIR++GD+ LGGLFPVHAKG  GVPCG++K+E GIHRLEAMLYA+DQIN DP+LL N+T
Sbjct: 41  HSIRIEGDVTLGGLFPVHAKGPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVT 100

Query: 98  LGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASS 157
           LG RILDTCSRDTYALEQSLTFVQALI+KD SDV+C NG+PP+F KP+K+ GVIGA+ SS
Sbjct: 101 LGARILDTCSRDTYALEQSLTFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSS 160

Query: 158 VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNY 217
           VSIMVANILRLF+IPQISYASTAPELSD+ RYDFFSRVVPPDS+QAQAMVDIV ALGWNY
Sbjct: 161 VSIMVANILRLFQIPQISYASTAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNY 220

Query: 218 VSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPRE--PRPGEFEKIIKRLLETPNA 275
           VSTLASEG+YGE GVE+FTQIS+E GG+CIAQS +IP+E   R  +F++IIK+LL+TPN+
Sbjct: 221 VSTLASEGSYGEKGVESFTQISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNS 280

Query: 276 RAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKR 335
           RAV++FAN++DI++IL AAK+ +Q GHFLW+GSDSWGSKI P++Q E+IAEGA+TI PKR
Sbjct: 281 RAVVIFANDEDIKQILAAAKRADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKR 340

Query: 336 ASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHG-KRNSHIKKCTGLERIARDS 394
           A+++GFD YF SRTL NNRRNVWFAE+WEENF CKL   G K+    +KCTG ERI +DS
Sbjct: 341 ATVEGFDAYFTSRTLENNRRNVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDS 400

Query: 395 SYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGS 454
           +YEQEGKVQFVIDAVY+MA+ALH+M+KDLC  Y G+CP M    GK+LL YIR VNFNGS
Sbjct: 401 NYEQEGKVQFVIDAVYAMAHALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRNVNFNGS 460

Query: 455 AGTPVTFNENGDAPGRYDIFQYQITNKSTE-YKVIGHWTNQLHLKVEDMQWAHREHTHPA 513
           AGTPV FN+NGDAPGRYDIFQYQ TN S   Y++IG WT++L L +EDMQW       PA
Sbjct: 461 AGTPVMFNKNGDAPGRYDIFQYQTTNTSNPGYRLIGQWTDELQLNIEDMQWGKGVREIPA 520

Query: 514 SVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGCQLIP 573
           SVC+LPCKPG+RKKT KG PCCW CE C+GY YQ DE++C+ CP DQRPN NRTGCQ IP
Sbjct: 521 SVCTLPCKPGQRKKTQKGTPCCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQDIP 580

Query: 574 IIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCY 633
           IIKLEWHSPWAV+PVF+A+LGIIAT FV+ TF+RYNDTPIVRASGRELSYVLLTGIFLCY
Sbjct: 581 IIKLEWHSPWAVIPVFLAMLGIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCY 640

Query: 634 SITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPA 693
            ITFLMIA PD  +CSFRRVFLGLGMC SYAALLTKTNRI+RIFEQGKKSVTAP+ ISP 
Sbjct: 641 IITFLMIAKPDVAVCSFRRVFLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPT 700

Query: 694 SQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSL 753
           SQL IT SLISVQLLGVF+WF VDPP+IIIDY E +T++PE+ARGVLKCDI+DL +ICSL
Sbjct: 701 SQLAITSSLISVQLLGVFIWFGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSL 760

Query: 754 GYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813
           GYSILLMVTCTVYAIKTRGVPE FNEAKPIGFTMYTTCI+WLAFIPIFFGTAQSAEK+YI
Sbjct: 761 GYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYI 820

Query: 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKG 873
           QTTTLT+SM+LSASV+LGMLYMPKVYIIIFHPE NVQKRKRSFKAVVTAATM S+L  K 
Sbjct: 821 QTTTLTISMNLSASVALGMLYMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKP 880

Query: 874 NDRPNGEVKSELCESLETNS 893
           +DRPNGE K+ELCE+++ N+
Sbjct: 881 SDRPNGEAKTELCENVDPNN 900


>gi|110611176 glutamate receptor, metabotropic 6 precursor [Homo
           sapiens]
          Length = 877

 Score = 1251 bits (3236), Expect = 0.0
 Identities = 602/836 (72%), Positives = 701/836 (83%), Gaps = 9/836 (1%)

Query: 37  AHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI 96
           A S+R+ G + LGGLFPVHA+G  G  CG+LKKE+G+HRLEAMLYA+D++N DP+LL  +
Sbjct: 30  AGSVRLAGGLTLGGLFPVHARGAAGRACGQLKKEQGVHRLEAMLYALDRVNADPELLPGV 89

Query: 97  TLGVRILDTCSRDTYALEQSLTFVQALI----EKDASDVKCANGDPPIF-TKPDKISGVI 151
            LG R+LDTCSRDTYALEQ+L+FVQALI    + D   V+C  G PP+    P+++  V+
Sbjct: 90  RLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEVGVRCPGGVPPLRPAPPERVVAVV 149

Query: 152 GAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVT 211
           GA+ASSVSIMVAN+LRLF IPQISYASTAPELSD+TRYDFFSRVVPPDSYQAQAMVDIV 
Sbjct: 150 GASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVR 209

Query: 212 ALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE 271
           ALGWNYVSTLASEGNYGESGVEAF QISRE GGVCIAQS KIPREP+PGEF K+I+RL+E
Sbjct: 210 ALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFSKVIRRLME 269

Query: 272 TPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTI 331
           TPNAR +I+FANEDDIRR+LEAA++ N +GHFLW+GSDSWG+K +P+   E++A GA+TI
Sbjct: 270 TPNARGIIIFANEDDIRRVLEAARQANLTGHFLWVGSDSWGAKTSPILSLEDVAVGAITI 329

Query: 332 LPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSH-IKKCTGLERI 390
           LPKRASIDGFD+YF +R+L NNRRN+WFAEFWEENF CKL S G ++    +KCTG ERI
Sbjct: 330 LPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGTQSDDSTRKCTGEERI 389

Query: 391 ARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVN 450
            RDS+YEQEGKVQFVIDAVY++A+ALH+MH+ LCPG+ GLCP M   DG+ LL YIRAV 
Sbjct: 390 GRDSTYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRMLLQYIRAVR 449

Query: 451 FNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTE---YKVIGHWTNQLHLKVEDMQWAHR 507
           FNGSAGTPV FNENGDAPGRYDIFQYQ TN S     Y+ +G W   L L VE +QW+  
Sbjct: 450 FNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAETLRLDVEALQWSGD 509

Query: 508 EHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRT 567
            H  P+S+CSLPC PGERKK VKGVPCCWHCE C+GY +QVDE +CE CP D RP  N T
Sbjct: 510 PHEVPSSLCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHT 569

Query: 568 GCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLT 627
           GC+  P+++L W SPWA  P+ +A+LGI+ATT V+ TFVRYN+TPIVRASGRELSYVLLT
Sbjct: 570 GCRPTPVVRLSWSSPWAAPPLLLAVLGIVATTTVVATFVRYNNTPIVRASGRELSYVLLT 629

Query: 628 GIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAP 687
           GIFL Y+ITFLM+A P   +C+ RR+FLGLG   SY+ALLTKTNRI+RIFEQGK+SVT P
Sbjct: 630 GIFLIYAITFLMVAEPGAAVCAARRLFLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPP 689

Query: 688 KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDL 747
            FISP SQLVITFSL S+Q++G+  W    PPH +IDY EQRT+DPE+ARGVLKCD+SDL
Sbjct: 690 PFISPTSQLVITFSLTSLQVVGMIAWLGARPPHSVIDYEEQRTVDPEQARGVLKCDMSDL 749

Query: 748 SLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807
           SLI  LGYS+LLMVTCTVYAIK RGVPETFNEAKPIGFTMYTTCIIWLAF+PIFFGTAQS
Sbjct: 750 SLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQS 809

Query: 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAA 863
           AEK+YIQTTTLTVS+SLSASVSLGMLY+PK Y+I+FHPEQNVQKRKRS KA  T A
Sbjct: 810 AEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKATSTVA 865


>gi|46358417 glutamate receptor, metabotropic 3 precursor [Homo
           sapiens]
          Length = 879

 Score =  746 bits (1926), Expect = 0.0
 Identities = 391/821 (47%), Positives = 530/821 (64%), Gaps = 30/821 (3%)

Query: 40  IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLG 99
           I+++GD++LGGLFP++ KG     CG + +++GI RLEAML+AID+INKD  LL  + LG
Sbjct: 33  IKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLG 92

Query: 100 VRILDTCSRDTYALEQSLTFVQALIEK-DASDVKCANGDPPIFTK-PDKISGVIGAAASS 157
           V ILDTCSRDTYALEQSL FV+A + K D ++  C +G   I    P  I+GVIG + SS
Sbjct: 93  VHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSS 152

Query: 158 VSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNY 217
           VSI VAN+LRLF+IPQISYAST+ +LSD +RYD+F+R VPPD YQA+AM +I+    W Y
Sbjct: 153 VSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTY 212

Query: 218 VSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARA 277
           VST+ASEG+YGE+G+EAF Q +R +  +CIA ++K+ R      ++ +I+ LL+ PNAR 
Sbjct: 213 VSTVASEGDYGETGIEAFEQEAR-LRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARV 271

Query: 278 VIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRAS 337
           V++F   DD R ++ AA + N S  F W+ SD WG++ + +   E +A GA+T+      
Sbjct: 272 VVLFMRSDDSRELIAAASRANAS--FTWVASDGWGAQESIIKGSEHVAYGAITLELASQP 329

Query: 338 IDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSS-Y 396
           +  FDRYF+S    NN RN WF +FWE+ F C L    KRN H + C   + +A DSS Y
Sbjct: 330 VRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSL--QNKRN-HRRVCD--KHLAIDSSNY 384

Query: 397 EQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL-GYIRAVNF---- 451
           EQE K+ FV++AVY+MA+ALH M + LCP    LC  M  +DGK+L   Y+  +NF    
Sbjct: 385 EQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPF 444

Query: 452 --NGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQWAHREH 509
             N  A + V F+  GD  GRY++F +Q       Y  +GHW   L L V  + W+   +
Sbjct: 445 NPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSR--N 502

Query: 510 THPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGC 569
           + P S CS PC P E K    G  CCW C  CE Y Y  DE +C  C   Q P  + TGC
Sbjct: 503 SVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGC 562

Query: 570 QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGI 629
             +P   + W   WA+ PV +A LG + T  V+  F+++N+TP+V+ASGREL Y+LL G+
Sbjct: 563 YDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGV 622

Query: 630 FLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKF 689
            L Y +TF  IA P  +IC+ RR+ LG      Y+ALLTKTN I RIF+  K     PKF
Sbjct: 623 GLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKF 682

Query: 690 ISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQR-TLDPEKARGVLKCDISDLS 748
           ISP+SQ+ I   LI VQ++ V VW +++ P      G +R TL  ++   +LKC++ D S
Sbjct: 683 ISPSSQVFICLGLILVQIVMVSVWLILEAP------GTRRYTLAEKRETVILKCNVKDSS 736

Query: 749 LICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSA 808
           ++ SL Y ++L++ CTVYA KTR  PE FNEAK IGFTMYTTCIIWLAF+PIF+ T+   
Sbjct: 737 MLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDY 796

Query: 809 EKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNV 849
               +QTTT+ +S+SLS  V LG L+ PKV+II+F P++NV
Sbjct: 797 R---VQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNV 834


>gi|66529100 glutamate receptor, metabotropic 2 isoform a precursor
           [Homo sapiens]
          Length = 872

 Score =  714 bits (1843), Expect = 0.0
 Identities = 384/847 (45%), Positives = 521/847 (61%), Gaps = 34/847 (4%)

Query: 40  IRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLG 99
           + ++GD++LGGLFPVH KG     CG + + +GI RLEAML+A+D+IN+DP LL  + LG
Sbjct: 26  LTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLG 85

Query: 100 VRILDTCSRDTYALEQSLTFVQALIEKDASDVK--CANGDPPIF-TKPDKISGVIGAAAS 156
             ILD+CS+DT+ALEQ+L FV+A + + A   +  C +G        P  I+GVIG + S
Sbjct: 86  AHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYS 145

Query: 157 SVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWN 216
            VSI VAN+LRLF+IPQISYAST+ +LSD +RYD+F+R VPPD +QA+AM +I+    W 
Sbjct: 146 DVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWT 205

Query: 217 YVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNAR 276
           YVST+ASEG+YGE+G+EAF ++      +C+A S+K+ R      FE +++ LL+ P+AR
Sbjct: 206 YVSTVASEGDYGETGIEAF-ELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSAR 264

Query: 277 AVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRA 336
             ++F   +D R +L A+++LN S  F W+ SD WG+  + V   E  AEGA+TI     
Sbjct: 265 VAVLFTRSEDARELLAASQRLNAS--FTWVASDGWGALESVVAGSEGAAEGAITIELASY 322

Query: 337 SIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSY 396
            I  F  YF+S    NN RN WF EFWE+ F C            + C       R   +
Sbjct: 323 PISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQ--------RDCAA--HSLRAVPF 372

Query: 397 EQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL-GYIRAVNFNG-- 453
           EQE K+ FV++AVY+MA+ALHNMH+ LCP    LC  M  ++G+ L   ++  V F+   
Sbjct: 373 EQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPF 432

Query: 454 ---SAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAHREH 509
                   V F+  GD  GRY+IF Y         Y+ +G+W   L L    + WA    
Sbjct: 433 RPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSA 492

Query: 510 TH-PASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTG 568
              PAS CS PC   E K    G  CCW C  C+ Y Y++DE +C  C L   PN + TG
Sbjct: 493 GPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTG 552

Query: 569 CQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTG 628
           C  +P   + W   WAV PV +A LG +AT FV+  FVR+N TP+V+ASGREL Y+LL G
Sbjct: 553 CFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGG 612

Query: 629 IFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPK 688
           +FLCY +TF+ IA P T +C+ RR+ LG      Y+ALLTKTNRI RIF   ++    P+
Sbjct: 613 VFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPR 672

Query: 689 FISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGV-LKCDISDL 747
           FISPASQ+ I  +LIS QLL V  W VV+ P      G  +   PE+   V L+C+  D 
Sbjct: 673 FISPASQVAICLALISGQLLIVVAWLVVEAP------GTGKETAPERREVVTLRCNHRDA 726

Query: 748 SLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807
           S++ SL Y++LL+  CT+YA KTR  PE FNEAK IGFTMYTTCIIWLAF+PIF+ T+  
Sbjct: 727 SMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSD 786

Query: 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQS 867
                +QTTT+ VS+SLS SV LG L+ PK++II+F P++NV   +       +AA   S
Sbjct: 787 YR---VQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARAS 843

Query: 868 KLIQKGN 874
             + +G+
Sbjct: 844 SSLGQGS 850


>gi|219842343 glutamate receptor, metabotropic 5 isoform a precursor
           [Homo sapiens]
          Length = 1212

 Score =  654 bits (1688), Expect = 0.0
 Identities = 360/823 (43%), Positives = 499/823 (60%), Gaps = 37/823 (4%)

Query: 44  GDIILGGLFPVHAKG------ERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNIT 97
           GDII+G LF VH +       ER   CG ++++ GI R+EAML+ +++IN DP LL NIT
Sbjct: 33  GDIIIGALFSVHHQPTVDKVHER--KCGAVREQYGIQRVEAMLHTLERINSDPTLLPNIT 90

Query: 98  LGVRILDTCSRDTYALEQSLTFVQALI---EKDASDVKCANGDPPIFTKPDKISGVIGAA 154
           LG  I D+C     ALEQS+ F++  +   E++   V+C +G    F     I GVIG  
Sbjct: 91  LGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPG 150

Query: 155 ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALG 214
           +SSV+I V N+L+LF IPQI+Y++T+ +LSD T + +F RVVP D+ QA+AMVDIV    
Sbjct: 151 SSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYN 210

Query: 215 WNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TP 273
           W YVS + +EGNYGESG+EAF  +S +  G+CIA S KI        F+K++K+L    P
Sbjct: 211 WTYVSAVHTEGNYGESGMEAFKDMSAK-EGICIAHSYKIYSNAGEQSFDKLLKKLTSHLP 269

Query: 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSK--IAPVYQQEEIAEGAVTI 331
            AR V  F     +R +L A ++L  +G FL +GSD W  +  +   YQ+E +  G +TI
Sbjct: 270 KARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAV--GGITI 327

Query: 332 LPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIA 391
             +   +  FD Y+       N RN WF EFW+  F C+L    + NS   K T    + 
Sbjct: 328 KLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNK-TCNSSLT 386

Query: 392 RDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNF 451
             + + Q+ K+ FVI+A+YSMAY LHNM   LCPGY GLC  M  IDG++LL  +   NF
Sbjct: 387 LKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNF 446

Query: 452 NGSAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAHREHT 510
            G +G  + F+ENGD+PGRY+I  ++   K   +Y  +G W N   LK++D +   ++  
Sbjct: 447 TGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNG-ELKMDDDEVWSKKSN 505

Query: 511 HPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGC 569
              SVCS PC+ G+ K   KG V CCW C  C+   Y  DE +C+ C L   P  + TGC
Sbjct: 506 IIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGC 565

Query: 570 QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGI 629
            LIP+  L W  P  +  V  A LG++AT FV V F+ Y DTP+V++S REL Y++L GI
Sbjct: 566 DLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGI 625

Query: 630 FLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTA--P 687
            L Y  TF +IA P  I C  +R+ +GL    SY+AL+TKTNRI RI    KK +    P
Sbjct: 626 CLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKP 685

Query: 688 KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDL 747
           +F+S  +QLVI F LI +QL  +   F+++PP I+ DY       P      L C+ ++L
Sbjct: 686 RFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDY-------PSIREVYLICNTTNL 738

Query: 748 SLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807
            ++  LGY+ LL+++CT YA KTR VP  FNEAK I FTMYTTCIIWLAF+PI+FG+   
Sbjct: 739 GVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGS--- 795

Query: 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
                 +  T+  S+SLSA+V+LG +++PKVYII+  PE+NV+
Sbjct: 796 ----NYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVR 834


>gi|4504143 glutamate receptor, metabotropic 5 isoform b precursor
           [Homo sapiens]
          Length = 1180

 Score =  654 bits (1688), Expect = 0.0
 Identities = 360/823 (43%), Positives = 499/823 (60%), Gaps = 37/823 (4%)

Query: 44  GDIILGGLFPVHAKG------ERGVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNIT 97
           GDII+G LF VH +       ER   CG ++++ GI R+EAML+ +++IN DP LL NIT
Sbjct: 33  GDIIIGALFSVHHQPTVDKVHER--KCGAVREQYGIQRVEAMLHTLERINSDPTLLPNIT 90

Query: 98  LGVRILDTCSRDTYALEQSLTFVQALI---EKDASDVKCANGDPPIFTKPDKISGVIGAA 154
           LG  I D+C     ALEQS+ F++  +   E++   V+C +G    F     I GVIG  
Sbjct: 91  LGCEIRDSCWHSAVALEQSIEFIRDSLISSEEEEGLVRCVDGSSSSFRSKKPIVGVIGPG 150

Query: 155 ASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALG 214
           +SSV+I V N+L+LF IPQI+Y++T+ +LSD T + +F RVVP D+ QA+AMVDIV    
Sbjct: 151 SSSVAIQVQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYN 210

Query: 215 WNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRLLE-TP 273
           W YVS + +EGNYGESG+EAF  +S +  G+CIA S KI        F+K++K+L    P
Sbjct: 211 WTYVSAVHTEGNYGESGMEAFKDMSAK-EGICIAHSYKIYSNAGEQSFDKLLKKLTSHLP 269

Query: 274 NARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSK--IAPVYQQEEIAEGAVTI 331
            AR V  F     +R +L A ++L  +G FL +GSD W  +  +   YQ+E +  G +TI
Sbjct: 270 KARVVACFCEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAV--GGITI 327

Query: 332 LPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKKCTGLERIA 391
             +   +  FD Y+       N RN WF EFW+  F C+L    + NS   K T    + 
Sbjct: 328 KLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNK-TCNSSLT 386

Query: 392 RDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNF 451
             + + Q+ K+ FVI+A+YSMAY LHNM   LCPGY GLC  M  IDG++LL  +   NF
Sbjct: 387 LKTHHVQDSKMGFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNF 446

Query: 452 NGSAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAHREHT 510
            G +G  + F+ENGD+PGRY+I  ++   K   +Y  +G W N   LK++D +   ++  
Sbjct: 447 TGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNG-ELKMDDDEVWSKKSN 505

Query: 511 HPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMNRTGC 569
              SVCS PC+ G+ K   KG V CCW C  C+   Y  DE +C+ C L   P  + TGC
Sbjct: 506 IIRSVCSEPCEKGQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGC 565

Query: 570 QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGI 629
            LIP+  L W  P  +  V  A LG++AT FV V F+ Y DTP+V++S REL Y++L GI
Sbjct: 566 DLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGI 625

Query: 630 FLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTA--P 687
            L Y  TF +IA P  I C  +R+ +GL    SY+AL+TKTNRI RI    KK +    P
Sbjct: 626 CLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIARILAGSKKKICTKKP 685

Query: 688 KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDL 747
           +F+S  +QLVI F LI +QL  +   F+++PP I+ DY       P      L C+ ++L
Sbjct: 686 RFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDY-------PSIREVYLICNTTNL 738

Query: 748 SLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQS 807
            ++  LGY+ LL+++CT YA KTR VP  FNEAK I FTMYTTCIIWLAF+PI+FG+   
Sbjct: 739 GVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGS--- 795

Query: 808 AEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
                 +  T+  S+SLSA+V+LG +++PKVYII+  PE+NV+
Sbjct: 796 ----NYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERNVR 834


>gi|166999223 glutamate receptor, metabotropic 1 isoform beta
           precursor [Homo sapiens]
          Length = 906

 Score =  642 bits (1656), Expect = 0.0
 Identities = 358/827 (43%), Positives = 503/827 (60%), Gaps = 36/827 (4%)

Query: 41  RVDGDIILGGLFPVHAKGE-RGVP---CGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI 96
           R+DGD+I+G LF VH +     VP   CGE++++ GI R+EAM + +D+IN DP LL NI
Sbjct: 40  RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNI 99

Query: 97  TLGVRILDTCSRDTYALEQSLTFVQALI-----EKDASDVKCANGD--PPIFTKPDKISG 149
           TLG  I D+C   + ALEQS+ F++  +     EKD  +    +G   PP  TK   I+G
Sbjct: 100 TLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKP-IAG 158

Query: 150 VIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI 209
           VIG  +SSV+I V N+L+LF IPQI+Y++T+ +LSD T Y +F RVVP D+ QA+AM+DI
Sbjct: 159 VIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI 218

Query: 210 VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269
           V    W YVS + +EGNYGESG++AF +++ +  G+CIA S KI        F++++++L
Sbjct: 219 VKRYNWTYVSAVHTEGNYGESGMDAFKELAAQ-EGLCIAHSDKIYSNAGEKSFDRLLRKL 277

Query: 270 LET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGA 328
            E  P AR V+ F     +R +L A ++L   G F  IGSD W  +   +   E  A G 
Sbjct: 278 RERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGG 337

Query: 329 VTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKK-CTGL 387
           +TI  +   +  FD YF    L  N RN WF EFW+  F C+L  H   N + K+ CTG 
Sbjct: 338 ITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGN 397

Query: 388 ERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIR 447
           E +  + +Y Q+ K+ FVI+A+Y+MA+ L NMH  LCPG++GLC  M  IDG +LL ++ 
Sbjct: 398 ESL--EENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLI 455

Query: 448 AVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAH 506
             +F G +G  V F+E GDAPGRYDI   Q T  +  +Y  +G W   + L ++D +   
Sbjct: 456 KSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQM 514

Query: 507 REHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMN 565
            +     SVCS PC  G+ K   KG V CCW C  C+   Y  DE +C+ C L   PN +
Sbjct: 515 NKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNAD 574

Query: 566 RTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVL 625
            TGC+ IP+  LEW +  +++ +  + LGI+ T FV + FV Y DTP+V++S REL Y++
Sbjct: 575 LTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYII 634

Query: 626 LTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVT 685
           L GIFL Y   F +IA P T  C  +R+ +GL     Y+AL+TKTNRI RI    KK + 
Sbjct: 635 LAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKIC 694

Query: 686 A--PKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCD 743
              P+F+S  +Q++I   LISVQL  V    +++PP  I+ Y       P      L C+
Sbjct: 695 TRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSY-------PSIKEVYLICN 747

Query: 744 ISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFG 803
            S+L ++  LGY+ LL+++CT YA KTR VP  FNEAK I FTMYTTCIIWLAF+PI+FG
Sbjct: 748 TSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG 807

Query: 804 TAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
           +         +  T   ++SLS +V+LG ++ PK+YIII  PE+NV+
Sbjct: 808 S-------NYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVR 847


>gi|166999098 glutamate receptor, metabotropic 1 isoform alpha
           precursor [Homo sapiens]
          Length = 1194

 Score =  642 bits (1656), Expect = 0.0
 Identities = 358/827 (43%), Positives = 503/827 (60%), Gaps = 36/827 (4%)

Query: 41  RVDGDIILGGLFPVHAKGE-RGVP---CGELKKEKGIHRLEAMLYAIDQINKDPDLLSNI 96
           R+DGD+I+G LF VH +     VP   CGE++++ GI R+EAM + +D+IN DP LL NI
Sbjct: 40  RMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNI 99

Query: 97  TLGVRILDTCSRDTYALEQSLTFVQALI-----EKDASDVKCANGD--PPIFTKPDKISG 149
           TLG  I D+C   + ALEQS+ F++  +     EKD  +    +G   PP  TK   I+G
Sbjct: 100 TLGSEIRDSCWHSSVALEQSIEFIRDSLISIRDEKDGINRCLPDGQSLPPGRTKKP-IAG 158

Query: 150 VIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI 209
           VIG  +SSV+I V N+L+LF IPQI+Y++T+ +LSD T Y +F RVVP D+ QA+AM+DI
Sbjct: 159 VIGPGSSSVAIQVQNLLQLFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDI 218

Query: 210 VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEKIIKRL 269
           V    W YVS + +EGNYGESG++AF +++ +  G+CIA S KI        F++++++L
Sbjct: 219 VKRYNWTYVSAVHTEGNYGESGMDAFKELAAQ-EGLCIAHSDKIYSNAGEKSFDRLLRKL 277

Query: 270 LET-PNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGA 328
            E  P AR V+ F     +R +L A ++L   G F  IGSD W  +   +   E  A G 
Sbjct: 278 RERLPKARVVVCFCEGMTVRGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGG 337

Query: 329 VTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKK-CTGL 387
           +TI  +   +  FD YF    L  N RN WF EFW+  F C+L  H   N + K+ CTG 
Sbjct: 338 ITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKRICTGN 397

Query: 388 ERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIR 447
           E +  + +Y Q+ K+ FVI+A+Y+MA+ L NMH  LCPG++GLC  M  IDG +LL ++ 
Sbjct: 398 ESL--EENYVQDSKMGFVINAIYAMAHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLI 455

Query: 448 AVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKST-EYKVIGHWTNQLHLKVEDMQWAH 506
             +F G +G  V F+E GDAPGRYDI   Q T  +  +Y  +G W   + L ++D +   
Sbjct: 456 KSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGV-LNIDDYKIQM 514

Query: 507 REHTHPASVCSLPCKPGERKKTVKG-VPCCWHCERCEGYNYQVDELSCELCPLDQRPNMN 565
            +     SVCS PC  G+ K   KG V CCW C  C+   Y  DE +C+ C L   PN +
Sbjct: 515 NKSGVVRSVCSEPCLKGQIKVIRKGEVSCCWICTACKENEYVQDEFTCKACDLGWWPNAD 574

Query: 566 RTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVL 625
            TGC+ IP+  LEW +  +++ +  + LGI+ T FV + FV Y DTP+V++S REL Y++
Sbjct: 575 LTGCEPIPVRYLEWSNIESIIAIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYII 634

Query: 626 LTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVT 685
           L GIFL Y   F +IA P T  C  +R+ +GL     Y+AL+TKTNRI RI    KK + 
Sbjct: 635 LAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSALVTKTNRIARILAGSKKKIC 694

Query: 686 A--PKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCD 743
              P+F+S  +Q++I   LISVQL  V    +++PP  I+ Y       P      L C+
Sbjct: 695 TRKPRFMSAWAQVIIASILISVQLTLVVTLIIMEPPMPILSY-------PSIKEVYLICN 747

Query: 744 ISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFG 803
            S+L ++  LGY+ LL+++CT YA KTR VP  FNEAK I FTMYTTCIIWLAF+PI+FG
Sbjct: 748 TSNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFG 807

Query: 804 TAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
           +         +  T   ++SLS +V+LG ++ PK+YIII  PE+NV+
Sbjct: 808 S-------NYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPERNVR 847


>gi|37577159 calcium-sensing receptor [Homo sapiens]
          Length = 1078

 Score =  402 bits (1034), Expect = e-112
 Identities = 289/940 (30%), Positives = 455/940 (48%), Gaps = 84/940 (8%)

Query: 23  WILTMMQRTHSQEYAHSIRVD--GDIILGGLFPVH----AKGE------RGVPCGELKKE 70
           W+L  +   H+  Y    R    GDIILGGLFP+H    AK +        V C      
Sbjct: 8   WVLLALT-WHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVECIRYNF- 65

Query: 71  KGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV-QALIEKDAS 129
           +G   L+AM++AI++IN  P LL N+TLG RI DTC+  + ALE +L+FV Q  I+    
Sbjct: 66  RGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKIDSLNL 125

Query: 130 DVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRY 189
           D  C N    I   P  I+ V+GA  S VS  VAN+L LF IPQ+SYAS++  LS+  ++
Sbjct: 126 DEFC-NCSEHI---PSTIA-VVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF 180

Query: 190 DFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQ 249
             F R +P D +QA AM DI+    WN+V T+A++ +YG  G+E F + + E   +CI  
Sbjct: 181 KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEE-RDICIDF 239

Query: 250 SQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSD 309
           S+ I +     E + +++ +++   A+ +++F++  D+  +++   + N +G  +W+ S+
Sbjct: 240 SELISQYSDEEEIQHVVE-VIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGK-IWLASE 297

Query: 310 SWGSK-IAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFG 368
           +W S  +  + Q   +  G +    K   I GF  + +      +  N +  EFWEE F 
Sbjct: 298 AWASSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFN 357

Query: 369 CKLGS-----------------HGKRNSHIKK-----CTGLERIAR-DSSYEQEGKVQF- 404
           C L                    G R S+        CTG E I+  ++ Y     ++  
Sbjct: 358 CHLQEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRIS 417

Query: 405 --VIDAVYSMAYALHNMHKDLCPGY----IGLCPRMSTIDGKELLGYIRAVNFNGSAGTP 458
             V  AVYS+A+AL +++  L PG      G C  +  ++  ++L ++R +NF  + G  
Sbjct: 418 YNVYLAVYSIAHALQDIYTCL-PGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQ 476

Query: 459 VTFNENGDAPGRYDIFQYQITNK--STEYKVIGHWT------NQLHLKVEDMQWAHREHT 510
           VTF+E GD  G Y I  + ++ +  S  +K +G++        +L +  E + W+     
Sbjct: 477 VTFDECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSRE 536

Query: 511 HPASVCSLPCKPGERKKTVKGVP-CCWHCERCEG--YNYQVDELSCELCPLDQRPNMNRT 567
            P S CS  C  G RK  ++G P CC+ C  C    Y+ + D  +C  CP D   N N T
Sbjct: 537 VPFSNCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHT 596

Query: 568 GCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLT 627
            C    I  L W  P+ +     A+LGI  T FV+  F+++ +TPIV+A+ RELSY+LL 
Sbjct: 597 SCIAKEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLF 656

Query: 628 GIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAP 687
            +  C+S +   I  P    C  R+   G+      + +L KTNR+  +FE    +    
Sbjct: 657 SLLCCFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHR 716

Query: 688 KFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKC-DISD 746
           K+     Q ++ F    +Q++   +W    PP         R  + E     + C + S 
Sbjct: 717 KWWGLNLQFLLVFLCTFMQIVICVIWLYTAPP------SSYRNQELEDEIIFITCHEGSL 770

Query: 747 LSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQ 806
           ++L   +GY+ LL   C  +A K+R +PE FNEAK I F+M    I+W++FIP +  T  
Sbjct: 771 MALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYG 830

Query: 807 SAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKR------SFKAVV 860
                      L  S  L     L  ++  K+YII+F P +N  +  R      +FK   
Sbjct: 831 KFVSAVEVIAILAASFGL-----LACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAA 885

Query: 861 TAATMQSKLIQKGNDRPNGEVKSELCESLETNSKSSVEFP 900
            A   +S + +K +    G   S    S+ + S S   FP
Sbjct: 886 RATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFP 925


>gi|112807234 G protein-coupled receptor, family C, group 6, member
           A [Homo sapiens]
          Length = 926

 Score =  249 bits (636), Expect = 8e-66
 Identities = 221/875 (25%), Positives = 388/875 (44%), Gaps = 74/875 (8%)

Query: 16  LLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAK---GERGVPCGELKKEKG 72
           +L   F  IL   Q   + +   +    G II+GGLF +H K    E      ++++  G
Sbjct: 6   ILITCFVIILATSQPCQTPDDFVAATSPGHIIIGGLFAIHEKMLSSEDSPRRPQIQECVG 65

Query: 73  IH-----RLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQAL-IEK 126
                  +  AM+++I+ IN    LL  + LG  I DTC+  T A+  +L F+      +
Sbjct: 66  FEISVFLQTLAMIHSIEMINNST-LLPGVKLGYEIYDTCTEVTVAMAATLRFLSKFNCSR 124

Query: 127 DASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDN 186
           +  + KC        +   ++  VIG+  S +++ V+ +L L  +PQ+ Y STA  LSD 
Sbjct: 125 ETVEFKCDYS-----SYMPRVKAVIGSGYSEITMAVSRMLNLQLMPQVGYESTAEILSDK 179

Query: 187 TRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVC 246
            R+  F R VP D +Q +AM  ++   GWN++  + ++ +YG   +  F  I  E   VC
Sbjct: 180 IRFPSFLRTVPSDFHQIKAMAHLIQKSGWNWIGIITTDDDYGRLALNTFI-IQAEANNVC 238

Query: 247 IAQSQKIPREPRPGEFE----KIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGH 302
           IA  + +P        E    + +K+++       +++F  +  +  +   A ++N +  
Sbjct: 239 IAFKEVLPAFLSDNTIEVRINRTLKKIILEAQVNVIVVFLRQFHVFDLFNKAIEMNINK- 297

Query: 303 FLWIGSDSW--GSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA 360
            +WI SD+W   +KI  +   ++I +  V    +R +I  F  + ++  L  +  +    
Sbjct: 298 -MWIASDNWSTATKITTIPNVKKIGK-VVGFAFRRGNISSFHSFLQNLHLLPSDSHKLLH 355

Query: 361 EFWEENFGCK----------LGSHGKRNSHIKKCTGLER--IARDS---SYEQEGKVQFV 405
           E+      C           + +H +R    K    +ER  + R+     Y + G +  +
Sbjct: 356 EYAMHLSACAYVKDTDLSQCIFNHSQRTLAYKANKAIERNFVMRNDFLWDYAEPGLIHSI 415

Query: 406 IDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENG 465
             AV+++ YA+    +DLC      C   +     ELLG ++ V F         F+ +G
Sbjct: 416 QLAVFALGYAI----RDLCQARD--CQNPNAFQPWELLGVLKNVTFT-DGWNSFHFDAHG 468

Query: 466 DAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKV---EDMQWAHREHTHPASVCSLPCKP 522
           D    YD+  ++  N       +  +  Q  + +   ++ +   R      S CS  C P
Sbjct: 469 DLNTGYDVVLWKEINGHMTVTKMAEYDLQNDVFIIPDQETKNEFRNLKQIQSKCSKECSP 528

Query: 523 GERKKTVKGVP-CCWHCERC--EGYNYQVDELSCELCPLDQR-PNMNRTGCQLIPIIKLE 578
           G+ KKT +    CC+ C+ C    Y  Q D   C LC        +  T C    +  L 
Sbjct: 529 GQMKKTTRSQHICCYECQNCPENHYTNQTDMPHCLLCNNKTHWAPVRSTMCFEKEVEYLN 588

Query: 579 WHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRAS-GRELSYVLLTGIFLCYSITF 637
           W+   A++ + +++LGII    V + F R  +TP+V++S G  + YV+L   FL ++ T 
Sbjct: 589 WNDSLAILLLILSLLGIIFVLVVGIIFTRNLNTPVVKSSGGLRVCYVILLCHFLNFASTS 648

Query: 638 LMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQ-L 696
             I  P    C  R+   G+      + +LTK+ +I   F    K     KF+    + +
Sbjct: 649 FFIGEPQDFTCKTRQTMFGVSFTLCISCILTKSLKILLAFSFDPK---LQKFLKCLYRPI 705

Query: 697 VITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDI-SDLSLICSLGY 755
           +I F+   +Q++   +W +   P + ++    R +       +L+C+  S L+    LGY
Sbjct: 706 LIIFTCTGIQVVICTLWLIFAAPTVEVNVSLPRVI-------ILECEEGSILAFGTMLGY 758

Query: 756 SILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQT 815
             +L   C ++A K  G  E +NEAK I F M    I W+ FIPI+  T       Y+  
Sbjct: 759 IAILAFICFIFAFK--GKYENYNEAKFITFGMLIYFIAWITFIPIYATTFGK----YVPA 812

Query: 816 TTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQ 850
             + V +  +  + L   ++PK Y+II   E N +
Sbjct: 813 VEIIVILISNYGI-LYCTFIPKCYVIICKQEINTK 846


>gi|112789566 taste receptor, type 1, member 2 [Homo sapiens]
          Length = 839

 Score =  219 bits (559), Expect = 7e-57
 Identities = 213/860 (24%), Positives = 376/860 (43%), Gaps = 90/860 (10%)

Query: 44  GDIILGGLFPVHAKGERGVPCGELK---------KEKGIHRLEAMLYAIDQINKDPDLLS 94
           GD +LGGLF +HA  +  V    L+         K  G + ++AM +A+++IN D  LL 
Sbjct: 31  GDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLP 90

Query: 95  NITLGVRILDTC--SRDTYALEQSLTFVQAL--IEKDASDVKCANGDPPIFTKPDKISGV 150
            + LG  I+D C  S +   +   L     L  I++D S+               ++  V
Sbjct: 91  GVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYI------------SRVVAV 138

Query: 151 IGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIV 210
           IG   S   + VAN L LF +PQI+Y++ + EL D  R+    R  P   +  +AMV ++
Sbjct: 139 IGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLM 198

Query: 211 TALGWNYVSTLASEGNYG-ESGVEAFTQISREIGGVCIAQSQKIPR-EPRPGEFEKIIKR 268
               WN++  L S   YG ++G     +++R    +CIA  + +P  +P      +  +R
Sbjct: 199 LHFRWNWIIVLVSSDTYGRDNGQLLGERVARR--DICIAFQETLPTLQPNQNMTSEERQR 256

Query: 269 L------LETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQE 322
           L      L+   AR V++F+ +  +        + N +G  +WI S+SW   I PV    
Sbjct: 257 LVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGA-VWIASESWA--IDPVLHNL 313

Query: 323 EIAEGAVTILP---KRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNS 379
                  T L    +   I GF  +      A        ++ +  N  C        ++
Sbjct: 314 TELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQEC--------DN 365

Query: 380 HIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNM---HKDLCPGYIGLCPRMST 436
            +        I R S    E  V  V  AVY++A+ALH++    K  C   +        
Sbjct: 366 CLNATLSFNTILRLSG---ERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRV-------- 414

Query: 437 IDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYK-VIGHWTNQL 495
           +   +LL  I  VNF       + F+  GD     +I Q+Q       ++ V  ++  Q 
Sbjct: 415 VYPWQLLEEIWKVNFT-LLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQR 473

Query: 496 HLK-VEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERC---EGYNYQVDEL 551
            LK ++D+ W    +T P S+CS  C+ G++KK V    CC+ C  C      N+  DE 
Sbjct: 474 QLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEY 533

Query: 552 SCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDT 611
            C+ CP ++    + T C    ++ LEWH    +    +A LG ++T  ++V F R+  T
Sbjct: 534 ECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQT 593

Query: 612 PIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTN 671
           PIVR++G  + +++LT + + Y +  + +  P    C  R+    L      + +  ++ 
Sbjct: 594 PIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSF 653

Query: 672 RIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTL 731
           +I   F+   +   A  +        ++ + I+V  + + V  +     +          
Sbjct: 654 QIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGM-----LATGLSPTTRT 708

Query: 732 DPEKAR-GVLKCDIS-DLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTM-- 787
           DP+  +  ++ C+ +   SL+ +    +LL V    +A   + +P  +NEAK I  +M  
Sbjct: 709 DPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTF 768

Query: 788 -YTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPE 846
            +T+ +    F+  + G       + +    L V++    ++SLG  + PK Y+I+F+PE
Sbjct: 769 YFTSSVSLCTFMSAYSG-------VLVTIVDLLVTVLNLLAISLG-YFGPKCYMILFYPE 820

Query: 847 QNVQKRKRSFKAVVTAATMQ 866
           +N       F +++   TM+
Sbjct: 821 RNT---PAYFNSMIQGYTMR 837


>gi|29294615 sweet taste receptor T1r isoform b [Homo sapiens]
          Length = 841

 Score =  218 bits (556), Expect = 2e-56
 Identities = 216/852 (25%), Positives = 363/852 (42%), Gaps = 88/852 (10%)

Query: 32  HSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK--------KEKGIHRLEAMLYAI 83
           HS E +    + GD +L GLFP+H+   +     E+          E G H  +AM   +
Sbjct: 24  HSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGV 83

Query: 84  DQINKDPDLLSNITLGVRILDTCS--RDTYALEQSLTFV-QALIEKDASDVKCANGDPPI 140
           ++IN    LL NITLG ++ D CS   + YA  + L+   Q  IE          GD  +
Sbjct: 84  EEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE--------LQGD--L 133

Query: 141 FTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200
                 +  VIG  +++ +   A +L  F +P ISYA+++  LS   +Y  F R +P D 
Sbjct: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193

Query: 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPG 260
           YQ + MV ++   GW ++S + S  +YG+ GV+A    +    G+CIA    +P   + G
Sbjct: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATG-QGICIAFKDIMPFSAQVG 252

Query: 261 -EFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW--GSKIAP 317
            E  + + R L    A  V++F++    R   E+    N +G  +W+ S++W     I  
Sbjct: 253 DERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAWALSRHITG 311

Query: 318 VYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKR 377
           V   + I       + KRA + G   +  +   A+ +              C  GS    
Sbjct: 312 VPGIQRIGMVLGVAIQKRA-VPGLKAFEEAYARADKK----------APRPCHKGSWCSS 360

Query: 378 NSHIKKCTG--------LERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIG 429
           N   ++C          L+  +  S+Y           AVY++A+ LH     L     G
Sbjct: 361 NQLCRECQAFMAHTMPKLKAFSMSSAYN-------AYRAVYAVAHGLH----QLLGCASG 409

Query: 430 LCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIG 489
            C R   +   +LL  I  V+F     T V FN+N D    Y+I  +        + V+G
Sbjct: 410 ACSR-GRVYPWQLLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWDWNGPKWTFTVLG 467

Query: 490 HWT---NQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNY 546
             T    QL++    +QW  +++  P SVCS  C  G ++       CC+ C  C    +
Sbjct: 468 SSTWSPVQLNINETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTF 527

Query: 547 --QVDELSCELCPLDQRPNMNRTGC--QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVI 602
             + D   C+ C  ++        C  + +  + L  H+ W ++     +L ++  T  +
Sbjct: 528 LNKSDLYRCQPCGKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGL 587

Query: 603 VTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFS 662
             F  + DTP+VR++G  L +++L  +       +     P    C  R+    LG    
Sbjct: 588 --FAWHLDTPVVRSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIF 645

Query: 663 YAALLTKTNRIHRIFEQGKKSVTAPKFI-----SPASQLVITFSLISVQLLGVFVWFVVD 717
            + L  ++ ++  IF   K S   P F      +  + L +  S  + QLL    W VV 
Sbjct: 646 LSCLTVRSFQLIIIF---KFSTKVPTFYHAWVQNHGAGLFVMIS-SAAQLLICLTWLVVW 701

Query: 718 PPHIIIDYGEQRTLDPEKARGVLKC-DISDLSLICSLGYSILLMVTCTVYAIKTRGVPET 776
            P    +Y     L       +L+C + + L  I +  Y+ LL ++    +   + +PE 
Sbjct: 702 TPLPAREYQRFPHL------VMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPEN 755

Query: 777 FNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMP 836
           +NEAK + F++    + W+A    FF TA   +  Y+    +   +S S S   G  ++P
Sbjct: 756 YNEAKCVTFSLLFNFVSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLP 810

Query: 837 KVYIIIFHPEQN 848
           K Y+I+  P+ N
Sbjct: 811 KCYVILCRPDLN 822


>gi|194248052 glutamate receptor, metabotropic 2 isoform b [Homo
           sapiens]
          Length = 254

 Score =  213 bits (541), Expect = 8e-55
 Identities = 116/241 (48%), Positives = 155/241 (64%), Gaps = 10/241 (4%)

Query: 635 ITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPAS 694
           +TF+ IA P T +C+ RR+ LG      Y+ALLTKTNRI RIF   ++    P+FISPAS
Sbjct: 1   MTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPAS 60

Query: 695 QLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGV-LKCDISDLSLICSL 753
           Q+ I  +LIS QLL V  W VV+ P      G  +   PE+   V L+C+  D S++ SL
Sbjct: 61  QVAICLALISGQLLIVVAWLVVEAP------GTGKETAPERREVVTLRCNHRDASMLGSL 114

Query: 754 GYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYI 813
            Y++LL+  CT+YA KTR  PE FNEAK IGFTMYTTCIIWLAF+PIF+ T+       +
Sbjct: 115 AYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYR---V 171

Query: 814 QTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKG 873
           QTTT+ VS+SLS SV LG L+ PK++II+F P++NV   +       +AA   S  + +G
Sbjct: 172 QTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQG 231

Query: 874 N 874
           +
Sbjct: 232 S 232


>gi|91206396 taste receptor, type 1, member 3 [Homo sapiens]
          Length = 852

 Score =  201 bits (511), Expect = 3e-51
 Identities = 187/834 (22%), Positives = 351/834 (42%), Gaps = 57/834 (6%)

Query: 37  AHSIRVDGDIILGGLFPVHAKGERGV--------PCGELKKEKGIHRLEAMLYAIDQINK 88
           +  +R+ GD +LGGLFP+    E G+        P        G+    AM  A+++IN 
Sbjct: 26  SQQLRMKGDYVLGGLFPLGEAEEAGLRSRTRPSSPVCTRFSSNGLLWALAMKMAVEEINN 85

Query: 89  DPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPPIFTKPDKIS 148
             DLL  + LG  + DTCS    A++ SL F+     +D +         P      ++ 
Sbjct: 86  KSDLLPGLRLGYDLFDTCSEPVVAMKPSLMFLAKAGSRDIAAYCNYTQYQP------RVL 139

Query: 149 GVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVD 208
            VIG  +S ++++       F +PQ+SY ++   LS    +  F R VP D  Q  A  +
Sbjct: 140 AVIGPHSSELAMVTGKFFSFFLMPQVSYGASMELLSARETFPSFFRTVPSDRVQLTAAAE 199

Query: 209 IVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIP----REPRPGEFEK 264
           ++   GWN+V+ L S+  YG  G+  F+ ++    G+CIA    +P     + R G+ + 
Sbjct: 200 LLQEFGWNWVAALGSDDEYGRQGLSIFSALA-AARGICIAHEGLVPLPRADDSRLGKVQD 258

Query: 265 IIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEI 324
           ++ ++ ++ + + V++FA+      +   +     S   +W+ S++W +    +      
Sbjct: 259 VLHQVNQS-SVQVVLLFASVHAAHALFNYSISSRLSPK-VWVASEAWLTSDLVMGLPGMA 316

Query: 325 AEGAVT-ILPKRASIDGFDRYFRSRTLANNRRNVWFAEFWEENFGCKLGSHGKRNSHIKK 383
             G V   L + A +  F +Y ++  LA      + +   E   G +    G+R      
Sbjct: 317 QMGTVLGFLQRGAQLHEFPQYVKTH-LALATDPAFCSALGEREQGLEEDVVGQRCPQC-D 374

Query: 384 CTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMHKDLCPGYIGLCPRMSTIDGKELL 443
           C  L+ ++   ++ Q      V  AVYS+A ALHN  +    G    CP    +   +LL
Sbjct: 375 CITLQNVSAGLNHHQTFS---VYAAVYSVAQALHNTLQCNASG----CPAQDPVKPWQLL 427

Query: 444 GYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWTNQLHLKVEDMQ 503
             +  + F+   G P+ F+ +G+    YD+  +           +G +   L  +   ++
Sbjct: 428 ENMYNLTFH-VGGLPLRFDSSGNVDMEYDLKLWVWQGSVPRLHDVGRFNGSLRTERLKIR 486

Query: 504 WAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCE--GYNYQVDELSCELCPLDQR 561
           W   ++  P S CS  C+ G+ ++      CC+ C  CE   Y    D+++C  C  D+ 
Sbjct: 487 WHTSDNQKPVSRCSRQCQEGQVRRVKGFHSCCYDCVDCEAGSYRQNPDDIACTFCGQDEW 546

Query: 562 PNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIVRASGREL 621
                T C       L W  P  ++ + +  L +      +  FV + D+P+V+ASG  L
Sbjct: 547 SPERSTRCFRRRSRFLAWGEPAVLLLLLLLSLALGLVLAALGLFVHHRDSPLVQASGGPL 606

Query: 622 SYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGK 681
           +   L  + L      L    P    C  ++    L +      L T   +   IF + +
Sbjct: 607 ACFGLVCLGLVCLSVLLFPGQPSPARCLAQQPLSHLPLT---GCLSTLFLQAAEIFVESE 663

Query: 682 KSVTAPKFIS-----PASQLVITFSLISVQLLGVFVWFVVD-PPHIIIDYGEQRTLDPEK 735
             ++    +S     P + LV+  +++    + +  W++V  PP ++ D+    T     
Sbjct: 664 LPLSWADRLSGCLRGPWAWLVVLLAMLVE--VALCTWYLVAFPPEVVTDWHMLPT----- 716

Query: 736 ARGVLKCDI-SDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIW 794
              ++ C   S +S   +   +  L   C +     R  P  +N A+ + F M    I W
Sbjct: 717 -EALVHCRTRSWVSFGLAHATNATLAFLCFLGTFLVRSQPGRYNRARGLTFAMLAYFITW 775

Query: 795 LAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQN 848
           ++F+P+         ++ ++      ++ L     L   ++P+ Y+++  P  N
Sbjct: 776 VSFVPLLANV-----QVVLRPAVQMGALLLCVLGILAAFHLPRCYLLMRQPGLN 824


>gi|29294617 sweet taste receptor T1r isoform a [Homo sapiens]
          Length = 480

 Score =  117 bits (293), Expect = 5e-26
 Identities = 87/292 (29%), Positives = 141/292 (48%), Gaps = 24/292 (8%)

Query: 32  HSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK--------KEKGIHRLEAMLYAI 83
           HS E +    + GD +L GLFP+H+   +     E+          E G H  +AM   +
Sbjct: 24  HSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGV 83

Query: 84  DQINKDPDLLSNITLGVRILDTCS--RDTYALEQSLTFV-QALIEKDASDVKCANGDPPI 140
           ++IN    LL NITLG ++ D CS   + YA  + L+   Q  IE          GD  +
Sbjct: 84  EEINNSTALLPNITLGYQLYDVCSDSANVYATLRVLSLPGQHHIE--------LQGD--L 133

Query: 141 FTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDS 200
                 +  VIG  +++ +   A +L  F +P ISYA+++  LS   +Y  F R +P D 
Sbjct: 134 LHYSPTVLAVIGPDSTNRAATTAALLSPFLVPMISYAASSETLSVKRQYPSFLRTIPNDK 193

Query: 201 YQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPG 260
           YQ + MV ++   GW ++S + S  +YG+ GV+A    +    G+CIA    +P   + G
Sbjct: 194 YQVETMVLLLQKFGWTWISLVGSSDDYGQLGVQALENQATG-QGICIAFKDIMPFSAQVG 252

Query: 261 -EFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQSGHFLWIGSDSW 311
            E  + + R L    A  V++F++    R   E+    N +G  +W+ S++W
Sbjct: 253 DERMQCLMRHLAQAGATVVVVFSSRQLARVFFESVVLTNLTGK-VWVASEAW 303


>gi|29294619 sweet taste receptor T1r isoform c [Homo sapiens]
          Length = 587

 Score =  114 bits (285), Expect = 4e-25
 Identities = 103/420 (24%), Positives = 179/420 (42%), Gaps = 31/420 (7%)

Query: 442 LLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWT---NQLHLK 498
           LL  I  V+F     T V FN+N D    Y+I  +        + V+G  T    QL++ 
Sbjct: 167 LLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNIN 225

Query: 499 VEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERCEGYNY--QVDELSCELC 556
              +QW  +++  P SVCS  C  G ++       CC+ C  C    +  + D   C+ C
Sbjct: 226 ETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPCGAGTFLNKSDLYRCQPC 285

Query: 557 PLDQRPNMNRTGC--QLIPIIKLEWHSPWAVVPVFVAILGIIATTFVIVTFVRYNDTPIV 614
             ++        C  + +  + L  H+ W ++     +L ++  T  +  F  + DTP+V
Sbjct: 286 GKEEWAPEGSQTCFPRTVVFLALREHTSWVLLAANTLLLLLLLGTAGL--FAWHLDTPVV 343

Query: 615 RASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIH 674
           R++G  L +++L  +       +     P    C  R+    LG     + L  ++ ++ 
Sbjct: 344 RSAGGRLCFLMLGSLAAGSGSLYGFFGEPTRPACLLRQALFALGFTIFLSCLTVRSFQLI 403

Query: 675 RIFEQGKKSVTAPKFI-----SPASQLVITFSLISVQLLGVFVWFVVDPPHIIIDYGEQR 729
            IF   K S   P F      +  + L +  S  + QLL    W VV  P    +Y    
Sbjct: 404 IIF---KFSTKVPTFYHAWVQNHGAGLFVMIS-SAAQLLICLTWLVVWTPLPAREYQRFP 459

Query: 730 TLDPEKARGVLKC-DISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMY 788
            L       +L+C + + L  I +  Y+ LL ++    +   + +PE +NEAK + F++ 
Sbjct: 460 HL------VMLECTETNSLGFILAFLYNGLLSISAFACSYLGKDLPENYNEAKCVTFSLL 513

Query: 789 TTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQN 848
              + W+A    FF TA   +  Y+    +   +S S S   G  ++PK Y+I+  P+ N
Sbjct: 514 FNFVSWIA----FFTTASVYDGKYLPAANMMAGLS-SLSSGFGGYFLPKCYVILCRPDLN 568



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 8/84 (9%)

Query: 32  HSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK--------KEKGIHRLEAMLYAI 83
           HS E +    + GD +L GLFP+H+   +     E+          E G H  +AM   +
Sbjct: 24  HSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGV 83

Query: 84  DQINKDPDLLSNITLGVRILDTCS 107
           ++IN    LL NITLG ++ D CS
Sbjct: 84  EEINNSTALLPNITLGYQLYDVCS 107


>gi|40255245 G protein-coupled receptor 51 [Homo sapiens]
          Length = 941

 Score = 68.6 bits (166), Expect = 3e-11
 Identities = 63/284 (22%), Positives = 135/284 (47%), Gaps = 26/284 (9%)

Query: 590 VAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLM-----IAAPD 644
           + ILG+I  +  +   ++  +  +++ S   ++ +++ G  L Y+  FL        +  
Sbjct: 488 LTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEK 547

Query: 645 TI--ICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSL 702
           T   +C+ R   L +G   ++ A+  KT R+H IF+  K      K I     LVI   +
Sbjct: 548 TFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMK---KKIIKDQKLLVIVGGM 604

Query: 703 ISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKA------RGVLK-CDISDLSLICSLGY 755
           + + L  +  W  VDP    +   E+ +++P+ A      R +L+ C+ + +++   + Y
Sbjct: 605 LLIDLCILICWQAVDPLRRTV---EKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVY 661

Query: 756 SI--LLMVTCTVYAIKTRGVP-ETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMY 812
           +   LLM+     A +TR V     N++K IG ++Y   I+ +    + F T    ++  
Sbjct: 662 AYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLT---RDQPN 718

Query: 813 IQTTTLTVSMSLSASVSLGMLYMPKVYIIIFHPEQNVQKRKRSF 856
           +Q   + + +   ++++L ++++PK+  +  +P+   Q R+  F
Sbjct: 719 VQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQF 762



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 29/104 (27%), Positives = 55/104 (52%), Gaps = 7/104 (6%)

Query: 150 VIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDI 209
           V G    SV+ ++A  L+ + + Q+S+A+T P L+D  +Y +F R VP D+    A++ +
Sbjct: 130 VFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKL 189

Query: 210 VTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKI 253
           +    W  V TL  +       V+ F+++  ++ GV   +  +I
Sbjct: 190 LKHYQWKRVGTLTQD-------VQRFSEVRNDLTGVLYGEDIEI 226


>gi|167000400 gamma-aminobutyric acid (GABA) B receptor 1 isoform c
           precursor [Homo sapiens]
          Length = 899

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 51/242 (21%), Positives = 103/242 (42%), Gaps = 22/242 (9%)

Query: 647 ICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQ 706
           +C  R   LGLG    Y ++ TK   +H +F + ++     K + P         L+ + 
Sbjct: 600 VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD 659

Query: 707 LLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICS-----------LGY 755
           +L + +W +VDP H  I+     T   E+ +  +   I      CS            GY
Sbjct: 660 VLTLAIWQIVDPLHRTIE-----TFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 714

Query: 756 SILLMVTCTVYAIKTRGV-PETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQ 814
             LL++     A +T+ V  E  N+ + +G  +Y   ++ L   P+    +   +  +  
Sbjct: 715 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF-- 772

Query: 815 TTTLTVSMSLSASVSLGMLYMPKVYIIIFHPE--QNVQKRKRSFKAVVTAATMQSKLIQK 872
               ++++  S+ ++L +L++PK+  +I   E     Q   ++  +       +S+L++K
Sbjct: 773 -AFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEK 831

Query: 873 GN 874
            N
Sbjct: 832 EN 833



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 47/196 (23%), Positives = 85/196 (43%), Gaps = 17/196 (8%)

Query: 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204
           D I  ++    SSVS +VA   R++ +  +SY S++P LS+  R+  F R  P  +    
Sbjct: 174 DPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNP 233

Query: 205 AMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEK 264
             V +    GW  ++T+        S ++   +  +E  G+ I   Q    +P       
Sbjct: 234 TRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKE-AGIEITFRQSFFSDP------A 286

Query: 265 IIKRLLETPNARAVIMFANEDDIRRIL-EAAKKLNQSGHFLW--IG--SDSWGSKIAP-- 317
           +  + L+  +AR ++    E + R++  E  K+      ++W  IG  +D+W     P  
Sbjct: 287 VPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSI 346

Query: 318 ---VYQQEEIAEGAVT 330
              V +  E  EG +T
Sbjct: 347 NCTVDEMTEAVEGHIT 362


>gi|11497612 gamma-aminobutyric acid (GABA) B receptor 1 isoform b
           precursor [Homo sapiens]
          Length = 844

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 51/242 (21%), Positives = 103/242 (42%), Gaps = 22/242 (9%)

Query: 647 ICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQ 706
           +C  R   LGLG    Y ++ TK   +H +F + ++     K + P         L+ + 
Sbjct: 545 VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD 604

Query: 707 LLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICS-----------LGY 755
           +L + +W +VDP H  I+     T   E+ +  +   I      CS            GY
Sbjct: 605 VLTLAIWQIVDPLHRTIE-----TFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 659

Query: 756 SILLMVTCTVYAIKTRGV-PETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQ 814
             LL++     A +T+ V  E  N+ + +G  +Y   ++ L   P+    +   +  +  
Sbjct: 660 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF-- 717

Query: 815 TTTLTVSMSLSASVSLGMLYMPKVYIIIFHPE--QNVQKRKRSFKAVVTAATMQSKLIQK 872
               ++++  S+ ++L +L++PK+  +I   E     Q   ++  +       +S+L++K
Sbjct: 718 -AFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEK 776

Query: 873 GN 874
            N
Sbjct: 777 EN 778



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 70/319 (21%), Positives = 122/319 (38%), Gaps = 62/319 (19%)

Query: 28  MQRTHSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELKKEKGIHRLEAMLYAIDQIN 87
           + R HS+   H       + +G LFP+      G  C             A+  A++ +N
Sbjct: 35  LPRPHSRVPPHPSSERRAVYIGALFPMSGGWPGGQACQP-----------AVEMALEDVN 83

Query: 88  KDPDLLSNITLGVRILDTCSRDTYALEQSLTFVQALIEKDASDVKCANGDPP------IF 141
              D+L +  L                        LI  D+   KC  G         ++
Sbjct: 84  SRRDILPDYEL-----------------------KLIHHDS---KCDPGQATKYLYELLY 117

Query: 142 TKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSY 201
             P KI  ++    SSVS +VA   R++ +  +SY S++P LS+  R+  F R  P  + 
Sbjct: 118 NDPIKI--ILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATL 175

Query: 202 QAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGE 261
                V +    GW  ++T+        S ++   +  +E  G+ I   Q    +P    
Sbjct: 176 HNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKE-AGIEITFRQSFFSDP---- 230

Query: 262 FEKIIKRLLETPNARAVIMFANEDDIRRIL-EAAKKLNQSGHFLW--IG--SDSWGSKIA 316
              +  + L+  +AR ++    E + R++  E  K+      ++W  IG  +D+W     
Sbjct: 231 --AVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYD 288

Query: 317 P-----VYQQEEIAEGAVT 330
           P     V +  E  EG +T
Sbjct: 289 PSINCTVDEMTEAVEGHIT 307


>gi|10835015 gamma-aminobutyric acid (GABA) B receptor 1 isoform a
           precursor [Homo sapiens]
          Length = 961

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 51/242 (21%), Positives = 103/242 (42%), Gaps = 22/242 (9%)

Query: 647 ICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQ 706
           +C  R   LGLG    Y ++ TK   +H +F + ++     K + P         L+ + 
Sbjct: 662 VCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMD 721

Query: 707 LLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICS-----------LGY 755
           +L + +W +VDP H  I+     T   E+ +  +   I      CS            GY
Sbjct: 722 VLTLAIWQIVDPLHRTIE-----TFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGY 776

Query: 756 SILLMVTCTVYAIKTRGV-PETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQ 814
             LL++     A +T+ V  E  N+ + +G  +Y   ++ L   P+    +   +  +  
Sbjct: 777 KGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAF-- 834

Query: 815 TTTLTVSMSLSASVSLGMLYMPKVYIIIFHPE--QNVQKRKRSFKAVVTAATMQSKLIQK 872
               ++++  S+ ++L +L++PK+  +I   E     Q   ++  +       +S+L++K
Sbjct: 835 -AFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEK 893

Query: 873 GN 874
            N
Sbjct: 894 EN 895



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 47/196 (23%), Positives = 85/196 (43%), Gaps = 17/196 (8%)

Query: 145 DKISGVIGAAASSVSIMVANILRLFKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQ 204
           D I  ++    SSVS +VA   R++ +  +SY S++P LS+  R+  F R  P  +    
Sbjct: 236 DPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNP 295

Query: 205 AMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISREIGGVCIAQSQKIPREPRPGEFEK 264
             V +    GW  ++T+        S ++   +  +E  G+ I   Q    +P       
Sbjct: 296 TRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKE-AGIEITFRQSFFSDP------A 348

Query: 265 IIKRLLETPNARAVIMFANEDDIRRIL-EAAKKLNQSGHFLW--IG--SDSWGSKIAP-- 317
           +  + L+  +AR ++    E + R++  E  K+      ++W  IG  +D+W     P  
Sbjct: 349 VPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSI 408

Query: 318 ---VYQQEEIAEGAVT 330
              V +  E  EG +T
Sbjct: 409 NCTVDEMTEAVEGHIT 424


>gi|11496971 NMDA receptor 1 isoform NR1-1 precursor [Homo sapiens]
          Length = 885

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 33/140 (23%), Positives = 68/140 (48%), Gaps = 7/140 (5%)

Query: 169 FKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYG 228
           ++IP +   +     SD + +  F R VPP S+Q+    +++    WN++  L S+ + G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173

Query: 229 ESGVEAFTQISREIGGVCIAQSQKIPR-EPRPGEFEKIIKRLLETPNARAVIMFANEDDI 287
            +  +    +  E      ++++K+ + +P       ++    E   AR +I+ A+EDD 
Sbjct: 174 RAAQKRLETLLEERE----SKAEKVLQFDPGTKNVTALLMEAKEL-EARVIILSASEDDA 228

Query: 288 RRILEAAKKLNQSGH-FLWI 306
             +  AA  LN +G  ++W+
Sbjct: 229 ATVYRAAAMLNMTGSGYVWL 248


>gi|11038637 NMDA receptor 1 isoform NR1-3 precursor [Homo sapiens]
          Length = 938

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 33/140 (23%), Positives = 68/140 (48%), Gaps = 7/140 (5%)

Query: 169 FKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYG 228
           ++IP +   +     SD + +  F R VPP S+Q+    +++    WN++  L S+ + G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173

Query: 229 ESGVEAFTQISREIGGVCIAQSQKIPR-EPRPGEFEKIIKRLLETPNARAVIMFANEDDI 287
            +  +    +  E      ++++K+ + +P       ++    E   AR +I+ A+EDD 
Sbjct: 174 RAAQKRLETLLEERE----SKAEKVLQFDPGTKNVTALLMEAKEL-EARVIILSASEDDA 228

Query: 288 RRILEAAKKLNQSGH-FLWI 306
             +  AA  LN +G  ++W+
Sbjct: 229 ATVYRAAAMLNMTGSGYVWL 248


>gi|11038635 NMDA receptor 1 isoform NR1-2 precursor [Homo sapiens]
          Length = 901

 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 33/140 (23%), Positives = 68/140 (48%), Gaps = 7/140 (5%)

Query: 169 FKIPQISYASTAPELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYG 228
           ++IP +   +     SD + +  F R VPP S+Q+    +++    WN++  L S+ + G
Sbjct: 114 YRIPVLGLTTRMSIYSDKSIHLSFLRTVPPYSHQSSVWFEMMRVYSWNHIILLVSDDHEG 173

Query: 229 ESGVEAFTQISREIGGVCIAQSQKIPR-EPRPGEFEKIIKRLLETPNARAVIMFANEDDI 287
            +  +    +  E      ++++K+ + +P       ++    E   AR +I+ A+EDD 
Sbjct: 174 RAAQKRLETLLEERE----SKAEKVLQFDPGTKNVTALLMEAKEL-EARVIILSASEDDA 228

Query: 288 RRILEAAKKLNQSGH-FLWI 306
             +  AA  LN +G  ++W+
Sbjct: 229 ATVYRAAAMLNMTGSGYVWL 248


>gi|29294621 sweet taste receptor T1r isoform d [Homo sapiens]
          Length = 324

 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 29/84 (34%), Positives = 42/84 (50%), Gaps = 8/84 (9%)

Query: 32  HSQEYAHSIRVDGDIILGGLFPVHAKGERGVPCGELK--------KEKGIHRLEAMLYAI 83
           HS E +    + GD +L GLFP+H+   +     E+          E G H  +AM   +
Sbjct: 24  HSTESSPDFTLPGDYLLAGLFPLHSGCLQVRHRPEVTLCDRSCSFNEHGYHLFQAMRLGV 83

Query: 84  DQINKDPDLLSNITLGVRILDTCS 107
           ++IN    LL NITLG ++ D CS
Sbjct: 84  EEINNSTALLPNITLGYQLYDVCS 107



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 31/103 (30%), Positives = 46/103 (44%), Gaps = 4/103 (3%)

Query: 442 LLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITNKSTEYKVIGHWT---NQLHLK 498
           LL  I  V+F     T V FN+N D    Y+I  +        + V+G  T    QL++ 
Sbjct: 167 LLEQIHKVHFLLHKDT-VAFNDNRDPLSSYNIIAWDWNGPKWTFTVLGSSTWSPVQLNIN 225

Query: 499 VEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCERC 541
              +QW  +++  P SVCS  C  G ++       CC+ C  C
Sbjct: 226 ETKIQWHGKDNQVPKSVCSSDCLEGHQRVVTGFHHCCFECVPC 268


>gi|7706451 G protein-coupled receptor, family C, group 5, member B
           precursor [Homo sapiens]
          Length = 403

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 60/268 (22%), Positives = 112/268 (41%), Gaps = 40/268 (14%)

Query: 583 WAVVPVFVAILGIIATTFV-IVTFVRYNDTPIVRASGRE----LSYVLLTGIFLCYSITF 637
           W +V   VA  G + T  + ++  VR    P ++   ++    L ++ L G    + +TF
Sbjct: 55  WGIVVEAVAGAGALITLLLMLILLVRL---PFIKEKEKKSPVGLHFLFLLGTLGLFGLTF 111

Query: 638 LMIAAPDTIICSFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLV 697
             I   D  ICS RR   G+     ++ LL++  R+ R+   G    T P       QLV
Sbjct: 112 AFIIQEDETICSVRRFLWGVLFALCFSCLLSQAWRVRRLVRHG----TGP----AGWQLV 163

Query: 698 -ITFSLISVQLLGVFVWFVVDPPHIIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYS 756
            +   L+ VQ++    W V+            R   P        C    +  + +L Y 
Sbjct: 164 GLALCLMLVQVIIAVEWLVLT---------VLRDTRP-------ACAYEPMDFVMALIYD 207

Query: 757 ILLMVTCTVYAIKTRGVPETFNEAKPIG----FTMYTTCIIWLAFIPIF-FGTAQSAEKM 811
           ++L+V     A+ T  +   F   K  G     T + + +IW+A++ ++ FG  +  +  
Sbjct: 208 MVLLVVTLGLALFT--LCGKFKRWKLNGAFLLITAFLSVLIWVAWMTMYLFGNVKLQQGD 265

Query: 812 YIQTTTLTVSMSLSASVSLGMLYMPKVY 839
                TL ++++ S  V +    +P+++
Sbjct: 266 AWNDPTLAITLAASGWVFVIFHAIPEIH 293


>gi|93204867 G protein-coupled receptor 158 [Homo sapiens]
          Length = 1215

 Score = 43.1 bits (100), Expect = 0.001
 Identities = 63/260 (24%), Positives = 108/260 (41%), Gaps = 27/260 (10%)

Query: 589 FVAILGIIATTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIIC 648
           F A+  ++    ++V +  +     +RASG  L   +L G  L Y    ++   P T  C
Sbjct: 423 FQALCMLLDFVSMLVVY-HFRKAKSIRASGLILLETILFGSLLLYFPVVILYFEPSTFRC 481

Query: 649 SFRRVFLGLGMCFSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLL 708
              R    LG    Y  +  K +R+ ++F     S TA +        V+   +++V LL
Sbjct: 482 ILLRWARLLGFATVYGTVTLKLHRVLKVF----LSRTAQRIPYMTGGRVM--RMLAVILL 535

Query: 709 GVFVWFVVDPPHIIIDYGEQR--TLDPEKARGVL---KCDISDLSLICSLG-YSILLMVT 762
            VF WF++     +    E++   +   K    L    C I     + ++  +  LL   
Sbjct: 536 VVF-WFLIGWTSSVCQNLEKQISLIGQGKTSDHLIFNMCLIDRWDYMTAVAEFLFLLWGV 594

Query: 763 CTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAEK-----MYIQTTT 817
              YA++T  VP  F+E + +   ++   II   F  I F  A   +      +Y   T 
Sbjct: 595 YLCYAVRT--VPSAFHEPRYMAVAVHNELIISAIFHTIRFVLASRLQSDWMLMLYFAHTH 652

Query: 818 LTVSMSLSASVSLGMLYMPK 837
           LTV      +V++G+L +PK
Sbjct: 653 LTV------TVTIGLLLIPK 666


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,624,122
Number of Sequences: 37866
Number of extensions: 1454277
Number of successful extensions: 3258
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 33
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 3101
Number of HSP's gapped (non-prelim): 48
length of query: 908
length of database: 18,247,518
effective HSP length: 111
effective length of query: 797
effective length of database: 14,044,392
effective search space: 11193380424
effective search space used: 11193380424
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.