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Search of human proteins with 187608777
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
(1378 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens] 2751 0.0
gi|56676397 ankyrin repeat domain 11 [Homo sapiens] 111 4e-24
gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens] 103 1e-21
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 103 1e-21
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 103 1e-21
gi|188219549 ankyrin repeat domain 32 [Homo sapiens] 94 9e-19
gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 90 1e-17
gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 90 1e-17
gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens] 90 1e-17
gi|223634006 hypothetical protein LOC441869 [Homo sapiens] 87 1e-16
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 86 2e-16
gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens] 82 3e-15
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 82 5e-15
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 82 5e-15
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 82 5e-15
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 80 1e-14
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 78 5e-14
gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens] 76 2e-13
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun... 75 3e-13
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit... 75 3e-13
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo... 75 3e-13
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 75 4e-13
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 75 4e-13
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 75 4e-13
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 75 4e-13
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 75 4e-13
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 73 2e-12
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ... 73 2e-12
gi|14195601 protein phosphatase 1, regulatory (inhibitor) subuni... 73 2e-12
gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit... 73 2e-12
>gi|187608777 NF-kappa-B inhibitor-like protein 2 [Homo sapiens]
Length = 1378
Score = 2751 bits (7132), Expect = 0.0
Identities = 1378/1378 (100%), Positives = 1378/1378 (100%)
Query: 1 MSLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERA 60
MSLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERA
Sbjct: 1 MSLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERA 60
Query: 61 DDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDI 120
DDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDI
Sbjct: 61 DDPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDI 120
Query: 121 YDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTAL 180
YDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTAL
Sbjct: 121 YDHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTAL 180
Query: 181 CNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFM 240
CNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFM
Sbjct: 181 CNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFM 240
Query: 241 ESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLE 300
ESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLE
Sbjct: 241 ESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLE 300
Query: 301 EAEGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAT 360
EAEGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAT
Sbjct: 301 EAEGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLAT 360
Query: 361 TLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC 420
TLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC
Sbjct: 361 TLGDMKDHHGAVRHYEEELRLRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSC 420
Query: 421 AQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAES 480
AQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAES
Sbjct: 421 AQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAES 480
Query: 481 EALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEG 540
EALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEG
Sbjct: 481 EALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEG 540
Query: 541 QLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGIT 600
QLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGIT
Sbjct: 541 QLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGIT 600
Query: 601 PLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKARAM 660
PLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKARAM
Sbjct: 601 PLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKARAM 660
Query: 661 EMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSP 720
EMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSP
Sbjct: 661 EMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEASQAHVRVSP 720
Query: 721 GQAAPAMARPRRSRHGPASSSSSSEGEDSAGPARPSQKRPRCSATAQRVAAWTPGPASNR 780
GQAAPAMARPRRSRHGPASSSSSSEGEDSAGPARPSQKRPRCSATAQRVAAWTPGPASNR
Sbjct: 721 GQAAPAMARPRRSRHGPASSSSSSEGEDSAGPARPSQKRPRCSATAQRVAAWTPGPASNR 780
Query: 781 EAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALAPQAALIPEEECLAGDWLELDM 840
EAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALAPQAALIPEEECLAGDWLELDM
Sbjct: 781 EAATASTSRAAYQAAIRGVGSAQSRLGPGPPRGHSKALAPQAALIPEEECLAGDWLELDM 840
Query: 841 PLTRSRRPRPRGTGDNRRPSSTSGSDSEESRPRARAKQVRLTCMQSCSAPVNAGPSSLAS 900
PLTRSRRPRPRGTGDNRRPSSTSGSDSEESRPRARAKQVRLTCMQSCSAPVNAGPSSLAS
Sbjct: 841 PLTRSRRPRPRGTGDNRRPSSTSGSDSEESRPRARAKQVRLTCMQSCSAPVNAGPSSLAS 900
Query: 901 EPPGSPSTPRVSEPSGDSSAAGQPLGPAPPPPIRVRVQVQDHLFLIPVPHSSDTHSVAWL 960
EPPGSPSTPRVSEPSGDSSAAGQPLGPAPPPPIRVRVQVQDHLFLIPVPHSSDTHSVAWL
Sbjct: 901 EPPGSPSTPRVSEPSGDSSAAGQPLGPAPPPPIRVRVQVQDHLFLIPVPHSSDTHSVAWL 960
Query: 961 AEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEVLAEVTSWDLPPLTDRYR 1020
AEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEVLAEVTSWDLPPLTDRYR
Sbjct: 961 AEQAAQRYYQTCGLLPRLTLRKEGALLAPQDLIPDVLQSNDEVLAEVTSWDLPPLTDRYR 1020
Query: 1021 RACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGN 1080
RACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGN
Sbjct: 1021 RACQSLGQGEHQQVLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGN 1080
Query: 1081 RLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNP 1140
RLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNP
Sbjct: 1081 RLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNP 1140
Query: 1141 LGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNA 1200
LGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNA
Sbjct: 1141 LGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNA 1200
Query: 1201 LGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHL 1260
LGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHL
Sbjct: 1201 LGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHL 1260
Query: 1261 GDKAVRDLCRCLSLCPSLISLDLSANPEISCASLEELLSTLQKRPQGLSFLGLSGCAVQG 1320
GDKAVRDLCRCLSLCPSLISLDLSANPEISCASLEELLSTLQKRPQGLSFLGLSGCAVQG
Sbjct: 1261 GDKAVRDLCRCLSLCPSLISLDLSANPEISCASLEELLSTLQKRPQGLSFLGLSGCAVQG 1320
Query: 1321 PLGLGLWDKIAAQLRELQLCSRRLCAEDRDALRQLQPSRPGPGECTLDHGSKLFFRRL 1378
PLGLGLWDKIAAQLRELQLCSRRLCAEDRDALRQLQPSRPGPGECTLDHGSKLFFRRL
Sbjct: 1321 PLGLGLWDKIAAQLRELQLCSRRLCAEDRDALRQLQPSRPGPGECTLDHGSKLFFRRL 1378
>gi|56676397 ankyrin repeat domain 11 [Homo sapiens]
Length = 2663
Score = 111 bits (278), Expect = 4e-24
Identities = 54/116 (46%), Positives = 77/116 (66%), Gaps = 3/116 (2%)
Query: 521 KWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRF 580
K N+RN+ GET LHRA I G RR+++L+ +G +N +D+ GWT LHEACN G+ ++ +
Sbjct: 160 KVNKRNERGETRLHRAAIRGDARRIKELISEGADVNVKDFAGWTALHEACNRGYYDVAKQ 219
Query: 581 LLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
LL GA V+ +G + TPLHDA N GH++V +LLL G + RKG +PL+
Sbjct: 220 LLAAGAEVNT---KGLDDDTPLHDAANNGHYKVVKLLLRYGGNPQQSNRKGETPLK 272
>gi|157266328 BRCA1 associated RING domain 1 [Homo sapiens]
Length = 777
Score = 103 bits (256), Expect = 1e-21
Identities = 53/113 (46%), Positives = 71/113 (62%), Gaps = 3/113 (2%)
Query: 524 RRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 583
+RN GETLLH A I+G + V+ L++ G N +D+ GWTPLHEACN+GHL++V LL
Sbjct: 423 KRNHRGETLLHIASIKGDIPSVEYLLQNGSDPNVKDHAGWTPLHEACNHGHLKVVELLLQ 482
Query: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
H A V+ G Q +PLHDA GH ++ +LLL GAS GL P++
Sbjct: 483 HKALVNTTGYQ---NDSPLHDAAKNGHVDIVKLLLSYGASRNAVNIFGLRPVD 532
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 103 bits (256), Expect = 1e-21
Identities = 48/123 (39%), Positives = 76/123 (61%), Gaps = 3/123 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R+ K N+RN+ GET LH A I G +++V++L+ G +N +D+ GWTPLHEACN G+ +
Sbjct: 150 RQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYD 209
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+ + L+ GA D QG + TPLHD+ + GH ++ +LLL G + + G P++
Sbjct: 210 VAKILIAAGA---DVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVD 266
Query: 637 TLQ 639
+
Sbjct: 267 VAE 269
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 103 bits (256), Expect = 1e-21
Identities = 48/123 (39%), Positives = 76/123 (61%), Gaps = 3/123 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R+ K N+RN+ GET LH A I G +++V++L+ G +N +D+ GWTPLHEACN G+ +
Sbjct: 173 RQKDKVNKRNERGETPLHMAAIRGDVKQVKELISLGANVNVKDFAGWTPLHEACNVGYYD 232
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+ + L+ GA D QG + TPLHD+ + GH ++ +LLL G + + G P++
Sbjct: 233 VAKILIAAGA---DVNTQGLDDDTPLHDSASSGHRDIVKLLLRHGGNPFQANKHGERPVD 289
Query: 637 TLQ 639
+
Sbjct: 290 VAE 292
>gi|188219549 ankyrin repeat domain 32 [Homo sapiens]
Length = 1058
Score = 94.0 bits (232), Expect = 9e-19
Identities = 54/122 (44%), Positives = 74/122 (60%), Gaps = 5/122 (4%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVR-QGHPLNPRDYCGWTPLHEACNYGHLE 576
K +++ N GET LHRACI Q+ ++ L+ G +N +D GWTPLHEACNYG+
Sbjct: 796 KKMNFHKTNLKGETALHRACINNQVEKLILLLSLPGIDINVKDNAGWTPLHEACNYGNTV 855
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTR--KGLSP 634
V+ +L VD +G+TPLHDAL+ GH E+ +LLL+ G V L+ R KG P
Sbjct: 856 CVQEILQRCPEVDLL--TQVDGVTPLHDALSNGHVEIGKLLLQHGGPVLLQQRNAKGELP 913
Query: 635 LE 636
L+
Sbjct: 914 LD 915
>gi|239754054 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 90.1 bits (222), Expect = 1e-17
Identities = 77/261 (29%), Positives = 119/261 (45%), Gaps = 47/261 (18%)
Query: 415 QKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQE----AP-----ETETRLRELSVAEDE 465
Q +L+C R L + + + V+L +PQ+ AP +T+T + E +A++
Sbjct: 1007 QNSLAC----MRTLLTHEASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVE-KMAKNC 1061
Query: 466 DEEEEA-----------EEAAATAESEALEAGEVELSE------------GEDDTDGLTP 502
D E E + A S+ +E +VE TD ++
Sbjct: 1062 DTERNYIDRDQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSK 1121
Query: 503 QLEEDEELQ-------GHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555
+L +L H K + N+RN GE+ LH A G L V+ L+ G +
Sbjct: 1122 ELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADV 1181
Query: 556 NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615
N D GWTPLHEA N G ++I+ LL GA V+ + +GI PLHDA+ H + AE
Sbjct: 1182 NLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN---CENIDGILPLHDAVANNHLKAAE 1238
Query: 616 LLLERGASVTLRTRKGLSPLE 636
+LL+ GA+ + +K S L+
Sbjct: 1239 ILLQNGANPNQKDQKQKSALD 1259
Score = 79.7 bits (195), Expect = 2e-14
Identities = 51/139 (36%), Positives = 70/139 (50%), Gaps = 8/139 (5%)
Query: 503 QLEEDEELQGHLGRRKGSKW-----NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNP 557
Q+ ++E+ G + K +K NRRN GE L+++A + V +++G +N
Sbjct: 458 QIRKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQ 517
Query: 558 RDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELL 617
Y GWT LHEA G LL GA D +G ITPLHDA+ GH++VAELL
Sbjct: 518 PSYAGWTALHEASVGGFYRTASELLKGGA---DVNIKGLYQITPLHDAVMNGHYKVAELL 574
Query: 618 LERGASVTLRTRKGLSPLE 636
L GA R G L+
Sbjct: 575 LLNGADPLFRNDDGKCALD 593
>gi|239748581 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 90.1 bits (222), Expect = 1e-17
Identities = 77/261 (29%), Positives = 119/261 (45%), Gaps = 47/261 (18%)
Query: 415 QKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQE----AP-----ETETRLRELSVAEDE 465
Q +L+C R L + + + V+L +PQ+ AP +T+T + E +A++
Sbjct: 1007 QNSLAC----MRTLLTHEASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVE-KMAKNC 1061
Query: 466 DEEEEA-----------EEAAATAESEALEAGEVELSE------------GEDDTDGLTP 502
D E E + A S+ +E +VE TD ++
Sbjct: 1062 DTERNYIDRDQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSK 1121
Query: 503 QLEEDEELQ-------GHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555
+L +L H K + N+RN GE+ LH A G L V+ L+ G +
Sbjct: 1122 ELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADV 1181
Query: 556 NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615
N D GWTPLHEA N G ++I+ LL GA V+ + +GI PLHDA+ H + AE
Sbjct: 1182 NLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN---CENIDGILPLHDAVANNHLKAAE 1238
Query: 616 LLLERGASVTLRTRKGLSPLE 636
+LL+ GA+ + +K S L+
Sbjct: 1239 ILLQNGANPNQKDQKQKSALD 1259
Score = 79.7 bits (195), Expect = 2e-14
Identities = 51/139 (36%), Positives = 70/139 (50%), Gaps = 8/139 (5%)
Query: 503 QLEEDEELQGHLGRRKGSKW-----NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNP 557
Q+ ++E+ G + K +K NRRN GE L+++A + V +++G +N
Sbjct: 458 QIRKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQ 517
Query: 558 RDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELL 617
Y GWT LHEA G LL GA D +G ITPLHDA+ GH++VAELL
Sbjct: 518 PSYAGWTALHEASVGGFYRTASELLKGGA---DVNIKGLYQITPLHDAVMNGHYKVAELL 574
Query: 618 LERGASVTLRTRKGLSPLE 636
L GA R G L+
Sbjct: 575 LLNGADPLFRNDDGKCALD 593
>gi|239742600 PREDICTED: ankyrin repeat domain 31 [Homo sapiens]
Length = 1873
Score = 90.1 bits (222), Expect = 1e-17
Identities = 77/261 (29%), Positives = 119/261 (45%), Gaps = 47/261 (18%)
Query: 415 QKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQE----AP-----ETETRLRELSVAEDE 465
Q +L+C R L + + + V+L +PQ+ AP +T+T + E +A++
Sbjct: 1007 QNSLAC----MRTLLTHEASKLTNHVELFKKPQDYIPRAPTFLMNQTDTHIVE-KMAKNC 1061
Query: 466 DEEEEA-----------EEAAATAESEALEAGEVELSE------------GEDDTDGLTP 502
D E E + A S+ +E +VE TD ++
Sbjct: 1062 DTERNYIDRDQKIIYSNEPLSIVAHSQVIETTKVEKRRQNHLESETIHNIDSHSTDNMSK 1121
Query: 503 QLEEDEELQ-------GHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555
+L +L H K + N+RN GE+ LH A G L V+ L+ G +
Sbjct: 1122 ELANISKLSQREKKEISHKPGMKAGRINKRNARGESQLHLAVRRGNLPLVKALIESGADV 1181
Query: 556 NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615
N D GWTPLHEA N G ++I+ LL GA V+ + +GI PLHDA+ H + AE
Sbjct: 1182 NLNDNAGWTPLHEASNEGSIDIIVELLKAGAKVN---CENIDGILPLHDAVANNHLKAAE 1238
Query: 616 LLLERGASVTLRTRKGLSPLE 636
+LL+ GA+ + +K S L+
Sbjct: 1239 ILLQNGANPNQKDQKQKSALD 1259
Score = 79.7 bits (195), Expect = 2e-14
Identities = 51/139 (36%), Positives = 70/139 (50%), Gaps = 8/139 (5%)
Query: 503 QLEEDEELQGHLGRRKGSKW-----NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNP 557
Q+ ++E+ G + K +K NRRN GE L+++A + V +++G +N
Sbjct: 458 QIRKNEQFSGKKEKMKVNKISLHSINRRNIFGENLVYKAALHDDADLVHHCIKKGGNVNQ 517
Query: 558 RDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELL 617
Y GWT LHEA G LL GA D +G ITPLHDA+ GH++VAELL
Sbjct: 518 PSYAGWTALHEASVGGFYRTASELLKGGA---DVNIKGLYQITPLHDAVMNGHYKVAELL 574
Query: 618 LERGASVTLRTRKGLSPLE 636
L GA R G L+
Sbjct: 575 LLNGADPLFRNDDGKCALD 593
>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
Length = 399
Score = 86.7 bits (213), Expect = 1e-16
Identities = 65/162 (40%), Positives = 79/162 (48%), Gaps = 11/162 (6%)
Query: 474 AAATAESEALE-----AGEVELSEGEDDTD-GLTPQLEEDEELQGHLGRRKGSKWNRRND 527
AAA AL V+ +G T GL L ++++ LG G+ R+
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGH--GADPGIRDR 267
Query: 528 MGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAA 587
G + LHRA G L VQ LV QG ++ RD G TPLH A GH+E+ LLD GA
Sbjct: 268 HGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQ 327
Query: 588 VDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTR 629
VD G TPLH A GH LLL RGAS TLRT+
Sbjct: 328 VD---ATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQ 366
Score = 76.3 bits (186), Expect = 2e-13
Identities = 48/103 (46%), Positives = 57/103 (55%), Gaps = 3/103 (2%)
Query: 533 LHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPG 592
L +A G V L+RQG + RD+ G TPLH A GH +VR LL GA V G
Sbjct: 45 LLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPV---G 101
Query: 593 GQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
G T LH+A GH VAELLL+RGAS R+ GL+PL
Sbjct: 102 AVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPL 144
Score = 65.9 bits (159), Expect = 3e-10
Identities = 58/179 (32%), Positives = 80/179 (44%), Gaps = 24/179 (13%)
Query: 443 RLQPQEAPETETRLRELSVAEDEDEEEEAEEAAAT-AESEALEAGEVELSEGE-DDTDGL 500
R +P+E E E LR + E ++EEA T E ++ G L + GL
Sbjct: 5 RPEPREEEEEEQELRWM--------ELDSEEALGTRTEGPSVVQGWGHLLQAVWRGPAGL 56
Query: 501 TPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDY 560
QL R+G+ R+ G T LH A + G V+ L+++G P+ D
Sbjct: 57 VTQL-----------LRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDR 105
Query: 561 CGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLE 619
G T LHEA +GH + LL GA+ G G+TPLH A GH +A LLE
Sbjct: 106 AGRTALHEAAWHGHSRVAELLLQRGASAAARSG---TGLTPLHWAAALGHTLLAARLLE 161
Score = 51.2 bits (121), Expect = 7e-06
Identities = 35/100 (35%), Positives = 50/100 (50%), Gaps = 3/100 (3%)
Query: 536 ACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQG 595
A G+ ++ L+ +G ++ RD G T L A G + + LL HGA DPG +
Sbjct: 210 AAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGA---DPGIRD 266
Query: 596 CEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
G + LH A GH +LL+ +GA V R GL+PL
Sbjct: 267 RHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPL 306
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 85.9 bits (211), Expect = 2e-16
Identities = 84/274 (30%), Positives = 119/274 (43%), Gaps = 30/274 (10%)
Query: 1034 VLQAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAA 1093
+++A+E + + L L+ + L L L T L+ LRL N +GD L A
Sbjct: 1542 LMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEA 1601
Query: 1094 LGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLL 1153
L SL LDLS N +G G++ LA LPG L L ++DLS N + G LA L
Sbjct: 1602 LRAATSLEELDLSHNQIGDAGVQHLATILPG---LPELRKIDLSGNSISSAGGVQLAESL 1658
Query: 1154 HACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNAL---GAPALARTL 1210
C L L L G TALG A + +HL+ L L ++ L GA +LA+ L
Sbjct: 1659 VLCRRLEELMLGCNALG------DPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQAL 1712
Query: 1211 QSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKEGC------------------ALAH 1252
P + L +++A G + P+ R + C AL
Sbjct: 1713 DGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEV 1772
Query: 1253 LTLSANHLGDKAVRDLCRCLSLCPSLISLDLSAN 1286
+ LS N LGD+A +L + L L +DL N
Sbjct: 1773 ILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKN 1806
Score = 55.5 bits (132), Expect = 4e-07
Identities = 77/296 (26%), Positives = 111/296 (37%), Gaps = 69/296 (23%)
Query: 1045 LSFSACSLALDQAQLTPLLRALKLHTA-LRELRLAGNRLGDKCVAELVAALGTMPSLALL 1103
LS S +L D + LL++L L + L+ RL + + + +A L + LG L L
Sbjct: 1468 LSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEEL 1527
Query: 1104 DLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLLHACPLLSTLR 1163
DLS+N EG + L L G+ L+ L+ L +N +LA L H
Sbjct: 1528 DLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLN------SSTLALLTHR-------- 1573
Query: 1164 LQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLEL 1223
LS T L S L L+ N++G ++L A T
Sbjct: 1574 -----------LSQMTCLQS----------LRLNRNSIGDVGCCHLSEALRAAT------ 1606
Query: 1224 SSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDL 1283
+L L LS N +GD V+ L L P L +DL
Sbjct: 1607 -------------------------SLEELDLSHNQIGDAGVQHLATILPGLPELRKIDL 1641
Query: 1284 SANPEISCASLEELLSTLQKRPQGLSFLGLSGCAVQGPLGLGLWDKIAAQLRELQL 1339
S N S ++ S + R LG + A+ P LGL ++ LR L L
Sbjct: 1642 SGNSISSAGGVQLAESLVLCRRLEELMLGCN--ALGDPTALGLAQELPQHLRVLHL 1695
Score = 49.7 bits (117), Expect = 2e-05
Identities = 66/217 (30%), Positives = 83/217 (38%), Gaps = 26/217 (11%)
Query: 1075 LRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEEL 1134
LRL +L L+A L P L +DLS N L EG R +A + L +L
Sbjct: 847 LRLQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQLEDEGCRLMA---EAASQLHIARKL 903
Query: 1135 DLSMNPLGDGCGQSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTL 1194
DLS N L + + AC L+ L + L H+T + Q+ E K
Sbjct: 904 DLSDNGLSVAGVHCVLRAVSACWTLAELHIS---------LQHKTVIFMFAQEPEEQK-- 952
Query: 1195 SLSYNALGAPALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFRYLAKE---GCALA 1251
G A L SL L LSS L E L K C L
Sbjct: 953 -------GPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQLCKALGGSCHLG 1005
Query: 1252 HLTL--SANHLGDKAVRDLCRCLSLCPSLISLDLSAN 1286
HL L S N LGD+ L + L +L SL+LS N
Sbjct: 1006 HLHLDFSGNALGDEGAARLAQLLPGLGALQSLNLSEN 1042
Score = 48.9 bits (115), Expect = 3e-05
Identities = 91/350 (26%), Positives = 133/350 (38%), Gaps = 49/350 (14%)
Query: 1039 ELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMP 1098
+++ L C A +A L R+L L+ L LAG+++ + ++ LV AL P
Sbjct: 687 QIENLSFKSRKCGDAFAEA----LSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCP 742
Query: 1099 SLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLLHACPL 1158
L + N L + + + LP L L +LDLS N + C +L L
Sbjct: 743 QLKEVSFRDNQLSDQVVLNIVEVLP---HLPRLRKLDLSSNSI---CVSTLLCLARVAVT 796
Query: 1159 LSTLR-LQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGT 1217
T+R LQA F LS T + Q A L+ GA + + TL+
Sbjct: 797 CPTVRMLQAREADLIFLLSPPTETTAELQRAPDLQ--ESDGQRKGAQSRSLTLRLQKCQL 854
Query: 1218 LLHLELSSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPS 1277
+H + +A L +EG L + LS N L D+ R + S
Sbjct: 855 QVHDAEALIA---------------LLQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHI 899
Query: 1278 LISLDLSAN------------PEISCASLEELLSTLQKRPQGLSFLGLSGCAVQGPLGLG 1325
LDLS N +C +L EL +LQ + F +GP
Sbjct: 900 ARKLDLSDNGLSVAGVHCVLRAVSACWTLAELHISLQHKTVIFMF-AQEPEEQKGPQERA 958
Query: 1326 LW-DKIAAQL-RELQLCSRRL----CAEDRDALRQLQPSRPGPGECTLDH 1369
+ D + Q+ EL L SRR+ C L QL + G C L H
Sbjct: 959 AFLDSLMLQMPSELPLSSRRMRLTHCGLQEKHLEQL--CKALGGSCHLGH 1006
Score = 46.2 bits (108), Expect = 2e-04
Identities = 97/374 (25%), Positives = 137/374 (36%), Gaps = 79/374 (21%)
Query: 1036 QAVELQGLGLSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALG 1095
+ + + L L C L + A+ L+ L+ L E+ L+GN+L D+ + A
Sbjct: 838 KGAQSRSLTLRLQKCQLQVHDAEA--LIALLQEGPHLEEVDLSGNQLEDEGCRLMAEAAS 895
Query: 1096 TMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQSLEELDLSMN-----------PLGDG 1144
+ LDLS N L G+ + L + +L EL +S+ P
Sbjct: 896 QLHIARKLDLSDNGLSVAGVHCV---LRAVSACWTLAELHISLQHKTVIFMFAQEPEEQK 952
Query: 1145 CGQSLASLLHAC--------PLLST-LRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLS 1195
Q A+ L + PL S +RL CG H L A + HL L
Sbjct: 953 GPQERAAFLDSLMLQMPSELPLSSRRMRLTHCGLQEK----HLEQLCKALGGSCHLGHLH 1008
Query: 1196 LSY--NALGAPALARTLQSLPA-GTLLHLELSSVAAG----------------------- 1229
L + NALG AR Q LP G L L LS
Sbjct: 1009 LDFSGNALGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDIS 1068
Query: 1230 --------KGDSDLME-------PVFRYLAK-----EGCALAHLTLSANHLGDKAVRDLC 1269
+GD + P F AK + C L LS L ++ LC
Sbjct: 1069 FESQHILLRGDKTSRDMWATGSLPDFPAAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLC 1128
Query: 1270 RCLSLCPSLISLDLSANPEISCASLEELLSTLQKRPQGLSFLGLS--GCAVQGPLGLGLW 1327
L CP + L LS +S SLE LL L + PQ LS L LS G + + P L
Sbjct: 1129 ATLKDCPGPLELQLSCE-FLSDQSLETLLDCLPQLPQ-LSLLQLSQTGLSPKSPFLLANT 1186
Query: 1328 DKIAAQLRELQLCS 1341
+ +++++ L S
Sbjct: 1187 LSLCPRVKKVDLRS 1200
Score = 43.5 bits (101), Expect = 0.001
Identities = 75/307 (24%), Positives = 116/307 (37%), Gaps = 54/307 (17%)
Query: 1047 FSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPSLALLDLS 1106
F+ CSL+ Q + L L L ++ L+ N LGD + L+ L +P LLDLS
Sbjct: 1222 FTGCSLS--QEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLLDLS 1279
Query: 1107 SNHLGPEGLRQLAMGLPGQATLQSLEELDLSMNPLGDGCGQSLASLLHAC---PLLSTLR 1163
N + E L LP ++ + S+N G + +H TLR
Sbjct: 1280 HNSISQESALYLLETLPSCPRVR-----EASVN-----LGSEQSFRIHFSREDQAGKTLR 1329
Query: 1164 LQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGAPALARTLQSLPAGTLLHLEL 1223
L C F P H + L + + L L+L+ LG LA + L L
Sbjct: 1330 LSECSFRP----EHVSRLATGLSKSLQLTELTLTQCCLGQKQLA-----------ILLSL 1374
Query: 1224 SSVAAGKGDSDLMEPVFRYLAKEGCALAHLTLSANHLGDKAVRDLCRCLSLCPSLISLDL 1283
AG + EP A L+ L + A G S+ + +
Sbjct: 1375 VGRPAGLFSLRVQEP----WADRARVLSLLEVCAQASG---------------SVTEISI 1415
Query: 1284 SANPEISCASLEELLSTLQKRPQGLSFLGLSGC--AVQGPLGLGLWDKIAAQLRELQLCS 1341
S + C LE ++ P+ ++ L L+ C L +G + A+L++L L
Sbjct: 1416 SETQQQLCVQLE--FPRQEENPEAVA-LRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQ 1472
Query: 1342 RRLCAED 1348
LC +D
Sbjct: 1473 VNLCEDD 1479
Score = 38.9 bits (89), Expect = 0.034
Identities = 89/322 (27%), Positives = 124/322 (38%), Gaps = 52/322 (16%)
Query: 1045 LSFSACSLALDQAQLTPLLRALKLHTALRELRLAGNRLGDKCVAELVAALGTMPSLALLD 1104
L S C L + LT L LK EL+L+ L D+ + L+ L +P L+LL
Sbjct: 1112 LCLSECPL--EPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQ 1169
Query: 1105 LSSNHLGPEGLRQLAMGLP-----GQATLQSLEE--LDLSMNPLGDG--CG--------- 1146
LS L P+ LA L + L+SL L N +G CG
Sbjct: 1170 LSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEEEGVCCGRFTGCSLSQ 1229
Query: 1147 ---QSLASLLHACPLLSTLRLQACGFGPSFFLSHQTALGSAFQDAEHLKTLSLSYNALGA 1203
+SL LL C LS + L A G S L L LS+N++
Sbjct: 1230 EHVESLCWLLSKCKDLSQVDLSANLLGDSGL----RCLLECLPQVPISGLLDLSHNSISQ 1285
Query: 1204 PALARTLQSLPAGTLLHLELSSVAAGKGDSDLMEPVFR-YLAKEGCALAHLTLSANHLGD 1262
+ L++LP + + +SV G E FR + ++E A L LS
Sbjct: 1286 ESALYLLETLP--SCPRVREASVNLGS------EQSFRIHFSREDQAGKTLRLSECSFRP 1337
Query: 1263 KAVRDLCRCLSLCPSLISLDLSANPEISCASLEEL--LSTLQKRPQGLSFLGLSGCAVQG 1320
+ V L LS L L L+ C ++L L +L RP GL L VQ
Sbjct: 1338 EHVSRLATGLSKSLQLTELTLTQ----CCLGQKQLAILLSLVGRPAGLFSL-----RVQE 1388
Query: 1321 PLGLGLWDKIAAQLRELQLCSR 1342
P W A L L++C++
Sbjct: 1389 P-----WADRARVLSLLEVCAQ 1405
Score = 37.0 bits (84), Expect = 0.13
Identities = 29/81 (35%), Positives = 38/81 (46%), Gaps = 3/81 (3%)
Query: 1071 ALRELRLAGNRLGDKCVAELVAALGTMPSLALLDLSSNHLGPEGLRQLAMGLPGQATLQS 1130
AL + L+ N LGD+ AEL L M L +DL N + G LA GL A S
Sbjct: 1769 ALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGL---AQGSS 1825
Query: 1131 LEELDLSMNPLGDGCGQSLAS 1151
++ + L NP+ Q L S
Sbjct: 1826 IQVIRLWNNPIPCDMAQHLKS 1846
>gi|224028289 tetratricopeptide repeat domain 28 [Homo sapiens]
Length = 2481
Score = 82.4 bits (202), Expect = 3e-15
Identities = 111/499 (22%), Positives = 206/499 (41%), Gaps = 36/499 (7%)
Query: 17 AQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGER 76
A + RR EA+ LG +Y +AL H QEL++ + D G AH +
Sbjct: 744 AHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAHGHLAAV 803
Query: 77 LAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAA 136
+ Y A + + L+L L++ + + + +G T +++ + + +A
Sbjct: 804 YMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNMGITKMNM-------NVMEEAIGY 856
Query: 137 FEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNH 196
FE+ LA++ + L+ E R R Y NLG +E+L Y+ + + +A+ +
Sbjct: 857 FEQQLAMLQQ-----LSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYYEQYLSVAQSLN 911
Query: 197 LYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQVLQDLG 256
+D +A LG H G QA+ C E AH + + F +++ + + LG
Sbjct: 912 RMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLG 971
Query: 257 DFLAAKRALKKAYRLG---SQKPVQRAAIC-------QNLQHVLAVVRLQQQLEEA-EGR 305
++ A L++ + + ++ A C Q ++ A+ Q L+ A E
Sbjct: 972 NYEQAISCLERQLNIARDMKDRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETN 1031
Query: 306 DPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDM 365
+P LG + G F RA ++ L A ++ A + + + SL T +
Sbjct: 1032 NPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAA-KTVSYSSLGRTHHAL 1090
Query: 366 KDHHGAVRHYEEELRL--RSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQ 423
+++ AV + +E LRL + G +EAK + LS +G+ E ++ S +
Sbjct: 1091 QNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYR--ASALFE 1148
Query: 424 AQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEAL 483
R + Q L L+ +A + +S+ ++ AE A ++ L
Sbjct: 1149 TIRHEAQLSTDYKLSLFDLQTSSYQALQRVL----VSLGHHDEALAVAERGRTRAFADLL 1204
Query: 484 EAGEVELSEGEDDTDGLTP 502
VE G+ D+D +P
Sbjct: 1205 ----VERQTGQQDSDPYSP 1219
Score = 79.7 bits (195), Expect = 2e-14
Identities = 105/445 (23%), Positives = 175/445 (39%), Gaps = 81/445 (18%)
Query: 33 LGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPAALQHQHQ 92
+G G Y +A++ H QELQ+ +D A H + + + ALQH
Sbjct: 520 MGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNLAVAYQALGAHDRALQHYQN 579
Query: 93 YLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIV----DEEL 148
+L +A LR+ RA + +G H SR +QA +E+ L + D E
Sbjct: 580 HLNIARELRDIQSEARALSNLGNFHC-------SRGEYVQAAPYYEQYLRLAPDLQDMEG 632
Query: 149 EGTLAQ---------GELNE-------------------MRTRLYLNLGLTFESLQQTAL 180
EG + G E + + Y NLGL F++L +
Sbjct: 633 EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSK 692
Query: 181 CNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFM 240
+ + + LA+ + + FRA NLG I + A++ E AH ++ R +
Sbjct: 693 AEECQKYLLSLAQSLNNSQAKFRALGNLGDIFICKKDINGAIKFYEQQLGLAHQVKDRRL 752
Query: 241 ESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLE 300
E+ +A AL AYR+ + Q L+ + Q+L
Sbjct: 753 EA-----------------SAYAALGTAYRMIQKYDKALGYHTQELE-------VYQELS 788
Query: 301 EAEGRDPQGAMVICEQLGDL---FSKAGDFPRAAEAYQKQLRFAELLDRPGAERAIIHVS 357
+ G C G L + G + A + Y++QL + L P E A ++ +
Sbjct: 789 DLPGE--------CRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLE-AQVYGN 839
Query: 358 LATTLGDMKDHHGAVRHYEEELRL---RSGN--VLEEAKTWLNIALSREEAGDAYELLAP 412
+ T +M A+ ++E++L + SGN VL+ + + N+ E GD YE
Sbjct: 840 MGITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGD-YEEAIK 898
Query: 413 CFQKALSCAQQAQRPQLQRQVLQHL 437
+++ LS AQ R Q Q + + L
Sbjct: 899 YYEQYLSVAQSLNRMQDQAKAYRGL 923
Score = 69.3 bits (168), Expect = 2e-11
Identities = 105/462 (22%), Positives = 177/462 (38%), Gaps = 46/462 (9%)
Query: 17 AQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGER 76
A+ G + E LG G Y EAL H +L L + D + A +G
Sbjct: 264 AKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQLVLAMKLKDREAASSALSSLGHV 323
Query: 77 LAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYD-----HCQSRDALL 131
+ DYP AL Q + LA ++ R +G ++ + D C + +
Sbjct: 324 YTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNMGAVYIAMGDFENAVQCHEQHLKI 383
Query: 132 ---------QAQA------------AFEKSLAIVDEELEGTLAQGELNE--MRTRLYLNL 168
+A+A F+K+++ + LE LAQ EL E + R Y L
Sbjct: 384 AKDLGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYVLE--LAQ-ELMEKAIEMRAYAGL 440
Query: 169 GLTFESLQQTALCNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGA 228
G +Q Y + + +AE RA NLG IH G + A++ +
Sbjct: 441 GHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNLGIIHQMKGDYDTALKLHKTH 500
Query: 229 RECAHTMRKRFMESECCVVIAQVLQDLGDFLAAKRALKKAYRLGSQ--KPVQRAAICQNL 286
A + + + LG + A + ++ ++ + +A+ NL
Sbjct: 501 LCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQELQISMEVNDRASQASTHGNL 560
Query: 287 --------QHVLAVVRLQQQLEEA-EGRDPQGAMVICEQLGDLFSKAGDFPRAAEAYQKQ 337
H A+ Q L A E RD Q LG+ G++ +AA Y++
Sbjct: 561 AVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNLGNFHCSRGEYVQAAPYYEQY 620
Query: 338 LRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRLRSG--NVLEEAKTWLN 395
LR A L E + H +L + ++ AV++YE++L L + L +AK + N
Sbjct: 621 LRLAPDLQDMEGEGKVCH-NLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCN 679
Query: 396 IALSREEAGDAYELLAPCFQKALSCAQQAQRPQLQRQVLQHL 437
+ L+ + + + C + LS AQ Q + + L +L
Sbjct: 680 LGLAFKALLN-FSKAEECQKYLLSLAQSLNNSQAKFRALGNL 720
Score = 63.5 bits (153), Expect = 1e-09
Identities = 58/235 (24%), Positives = 99/235 (42%), Gaps = 15/235 (6%)
Query: 2 SLERELRQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERAD 61
SL++ L K A G+ +A +LG L + G Y +A+ ++L +
Sbjct: 932 SLQQALVCFEKRLVVAHELGEAFNKAQAYGELGSLHSQLGNYEQAISCLERQLNIARDMK 991
Query: 62 DPLGCAVAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIY 121
D + A +G +M +Y ALQ+ L++A N T RA+ +G T+
Sbjct: 992 DRALESDAACGLGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQGRAYGNLGLTY---- 1047
Query: 122 DHCQSRDALLQAQAAFEKSLAIVDEELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALC 181
++ FE+++ ++ L +L +T Y +LG T +LQ +
Sbjct: 1048 ----------ESLGTFERAVVYQEQHLSIAAQMNDL-AAKTVSYSSLGRTHHALQNYSQA 1096
Query: 182 NDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGARECAHTMR 236
Y ++ + LAEQ ED + R+ LG W +G +A L A T+R
Sbjct: 1097 VMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASALFETIR 1151
Score = 62.0 bits (149), Expect = 4e-09
Identities = 92/445 (20%), Positives = 174/445 (39%), Gaps = 54/445 (12%)
Query: 26 EAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCAVAHRKIGERLAEMEDYPA 85
E +CH LG G Y EA++ + Q+L L + D L A A+ +G + ++
Sbjct: 633 EGKVCHNLGYAHYCLGNYQEAVKYYEQDLALAKDLHDKLSQAKAYCNLGLAFKALLNFSK 692
Query: 86 ALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSRDALLQAQAAFEKSLAIVD 145
A + Q L LA SL N RA +G DI+ + ++ +
Sbjct: 693 AEECQKYLLSLAQSLNNSQAKFRALGNLG----DIF----------ICKKDINGAIKFYE 738
Query: 146 EELEGTLAQGELNEMRTRLYLNLGLTFESLQQTALCNDYFRKSIFLAEQNHLYEDLFRAR 205
++L G Q + + Y LG + +Q+ Y + + + ++ RA
Sbjct: 739 QQL-GLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQELEVYQELSDLPGECRAH 797
Query: 206 YNLGTIHWRAGQHSQAMRCLEGARECAHTMRKRFMESECCVVIAQVLQDLGDFLAAKRAL 265
+L ++ G+++ A +C E + ++ +E AQV ++G +
Sbjct: 798 GHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLE-------AQVYGNMGITKMNMNVM 850
Query: 266 KKAYRLGSQKPVQRAAICQNLQHVLAVVRLQQQLEEAEGRDPQGAMVICEQLGDLFSKAG 325
++A Q+ + + QQL E +G LGD + G
Sbjct: 851 EEAIGYFEQQ-----------------LAMLQQLSGNESVLDRGRAY--GNLGDCYEALG 891
Query: 326 DFPRAAEAYQKQLRFAELLDRPGAERAIIHVSLATTLGDMKDHHGAVRHYEEELRL--RS 383
D+ A + Y++ L A+ L+R ++A + L M A+ +E+ L +
Sbjct: 892 DYEEAIKYYEQYLSVAQSLNRM-QDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHEL 950
Query: 384 GNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQAQRPQLQRQVLQHLHTVQLR 443
G +A+ + + + G+ YE C ++ L+ A+ + L+ L V
Sbjct: 951 GEAFNKAQAYGELGSLHSQLGN-YEQAISCLERQLNIARDMKDRALESDAACGLGGVY-- 1007
Query: 444 LQPQEAPETETRLR----ELSVAED 464
Q+ E +T L+ +L +AE+
Sbjct: 1008 ---QQMGEYDTALQYHQLDLQIAEE 1029
Score = 55.8 bits (133), Expect = 3e-07
Identities = 58/229 (25%), Positives = 102/229 (44%), Gaps = 21/229 (9%)
Query: 8 RQLSKAKAKAQRAGQRREEAALCHQLGELLAGHGRYAEALEQHWQELQLRERADDPLGCA 67
RQL+ A+ RA E A C LG + G Y AL+ H +LQ+ E ++P
Sbjct: 982 RQLNIARDMKDRA---LESDAACG-LGGVYQQMGEYDTALQYHQLDLQIAEETNNPTCQG 1037
Query: 68 VAHRKIGERLAEMEDYPAALQHQHQYLELAHSLRNHTELQRAWATIGRTHLDIYDHCQSR 127
A+ +G + + A+ +Q Q+L +A + + +++++GRTH + ++ Q+
Sbjct: 1038 RAYGNLGLTYESLGTFERAVVYQEQHLSIAAQMNDLAAKTVSYSSLGRTHHALQNYSQA- 1096
Query: 128 DALLQAQAAFEKSLAIVDEELE-------GTLAQGELNEMRTRLYLNLGLTFESLQQTAL 180
LQ + L ++E + A G L E + +LY L FE+++ A
Sbjct: 1097 VMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQLYRASAL-FETIRHEAQ 1155
Query: 181 CNDYFRKSIFLAEQNHLYEDLFRARYNLGTIHWRAGQHSQAMRCLEGAR 229
+ ++ S+F Q Y+ L R +L G H +A+ E R
Sbjct: 1156 LSTDYKLSLF-DLQTSSYQALQRVLVSL-------GHHDEALAVAERGR 1196
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 81.6 bits (200), Expect = 5e-15
Identities = 71/265 (26%), Positives = 111/265 (41%), Gaps = 12/265 (4%)
Query: 381 LRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQAQR---PQLQRQVLQHL 437
L G+ ++ A N AL E++ ++ + Q+Q P H+
Sbjct: 63 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 122
Query: 438 HTVQLRLQ--PQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGED 495
V+ L+ ++ TE L+VA + + + + ++ +D
Sbjct: 123 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 182
Query: 496 DTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555
DT L+ D + NR + G T LH A G + L+ +G +
Sbjct: 183 DTKSAALLLQNDHNADV----QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 238
Query: 556 NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615
+ G TPLH A G+ +V+ LLD G +D + +G+TPLH A GH +V E
Sbjct: 239 DFTARNGITPLHVASKRGNTNMVKLLLDRGGQID---AKTRDGLTPLHCAARSGHDQVVE 295
Query: 616 LLLERGASVTLRTRKGLSPLETLQQ 640
LLLERGA + RT+ GLSPL Q
Sbjct: 296 LLLERGAPLLARTKNGLSPLHMAAQ 320
Score = 77.4 bits (189), Expect = 9e-14
Identities = 60/164 (36%), Positives = 79/164 (48%), Gaps = 10/164 (6%)
Query: 499 GLTPQLEEDEELQGHLG-----RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
GLTP GHL + G+ + N GET LH A GQ+ V+ L+R G
Sbjct: 410 GLTPI--HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 467
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEV 613
++ R TPLH A G EIV+ LL H A P G TPLH + G +V
Sbjct: 468 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMA---HPDAATTNGYTPLHISAREGQVDV 524
Query: 614 AELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKA 657
A +LLE GA+ +L T+KG +PL ++ L L L+ R A
Sbjct: 525 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Score = 73.2 bits (178), Expect = 2e-12
Identities = 50/154 (32%), Positives = 77/154 (50%), Gaps = 16/154 (10%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
+G + + + G T LH A G + V+ L+ +G PL R G +PLH A H+E
Sbjct: 267 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 326
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLET 637
V+ LL H A VDD + +T LH A +CGH+ V +LLL++ A+ R G +PL
Sbjct: 327 VKHLLQHKAPVDD---VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 383
Query: 638 LQQWVKLYRRDLDLETRQKARAMEMLLQAAASGQ 671
+ + + + ME+L++ AS Q
Sbjct: 384 ACK-------------KNRIKVMELLVKYGASIQ 404
Score = 68.2 bits (165), Expect = 5e-11
Identities = 63/212 (29%), Positives = 88/212 (41%), Gaps = 33/212 (15%)
Query: 436 HLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGED 495
HL+ V L LQ +P+ T +R TA A AG+VE+
Sbjct: 422 HLNIVLLLLQNGASPDV-TNIR-----------------GETALHMAARAGQVEVVRCLL 463
Query: 496 DTDGLTPQLEEDEELQGHLGRRKGSKW------------NRRNDMGETLLHRACIEGQLR 543
L +E+ H+ R G + G T LH + EGQ+
Sbjct: 464 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVD 523
Query: 544 RVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLH 603
L+ G + G+TPLH A YG L++ + LL AA D G G+TPLH
Sbjct: 524 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK---NGLTPLH 580
Query: 604 DALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
A + + +VA LLLE+GAS + G +PL
Sbjct: 581 VAAHYDNQKVALLLLEKGASPHATAKNGYTPL 612
Score = 65.9 bits (159), Expect = 3e-10
Identities = 40/118 (33%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
KG+ + G T LH A E ++ L + G + G+TPL AC+YG++++
Sbjct: 663 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 722
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
V FLL GA V+ + G TPLH A GH + +LL+ GA T G + L
Sbjct: 723 VNFLLKQGANVN---AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 777
Score = 65.5 bits (158), Expect = 3e-10
Identities = 49/154 (31%), Positives = 69/154 (44%), Gaps = 3/154 (1%)
Query: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
N N G LH A EG + VQ+L+ +G ++ G T LH A G E+V+ L+
Sbjct: 37 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 96
Query: 583 DHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWV 642
GA ++ Q G TPL+ A H +V + LLE GA+ + T G +PL Q
Sbjct: 97 KEGANIN---AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 153
Query: 643 KLYRRDLDLETRQKARAMEMLLQAAASGQDPHSS 676
+ LE K + L AA D S+
Sbjct: 154 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 187
Score = 65.5 bits (158), Expect = 3e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 8/122 (6%)
Query: 511 QGHLGR-----RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTP 565
+GH+G +GS + G T LH A + GQ V+ LV++G +N + G+TP
Sbjct: 53 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTP 112
Query: 566 LHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVT 625
L+ A H+++V++LL++GA + +G TPL AL GH + +LLE
Sbjct: 113 LYMAAQENHIDVVKYLLENGA---NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 169
Query: 626 LR 627
+R
Sbjct: 170 VR 171
Score = 65.5 bits (158), Expect = 3e-10
Identities = 43/113 (38%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
N R G T LH AC + +++ ++ LV+ G + G TP+H A GHL IV LL
Sbjct: 371 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 430
Query: 583 DHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+GA+ P G T LH A G EV LL GA V R R+ +PL
Sbjct: 431 QNGAS---PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 480
Score = 59.7 bits (143), Expect = 2e-08
Identities = 39/124 (31%), Positives = 57/124 (45%), Gaps = 3/124 (2%)
Query: 505 EEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWT 564
+ED+ + + G+ + +G T L AC G ++ V L++QG +N + G+T
Sbjct: 683 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 742
Query: 565 PLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASV 624
PLH+A GH I+ LL HGA P G T L A G+ V + L V
Sbjct: 743 PLHQAAQQGHTHIINVLLQHGA---KPNATTANGNTALAIAKRLGYISVVDTLKVVTEEV 799
Query: 625 TLRT 628
T T
Sbjct: 800 TTTT 803
Score = 56.6 bits (135), Expect = 2e-07
Identities = 39/121 (32%), Positives = 61/121 (50%), Gaps = 3/121 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH A + L+ +G + G+TPLH A ++I LL++GA
Sbjct: 575 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 634
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRD 648
+ QG +TPLH A GH ++ LLL++GA++ + T+ GL+ L Q K+ D
Sbjct: 635 NIVTKQG---VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 691
Query: 649 L 649
+
Sbjct: 692 I 692
Score = 55.5 bits (132), Expect = 4e-07
Identities = 45/141 (31%), Positives = 62/141 (43%), Gaps = 6/141 (4%)
Query: 498 DGLTP---QLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHP 554
+GLTP D + L KG+ + G T LH A + Q++ L+ G
Sbjct: 574 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 633
Query: 555 LNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVA 614
N G TPLH A GH ++V LLD GA + G+T LH A VA
Sbjct: 634 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH---MSTKSGLTSLHLAAQEDKVNVA 690
Query: 615 ELLLERGASVTLRTRKGLSPL 635
++L + GA T+ G +PL
Sbjct: 691 DILTKHGADQDAHTKLGYTPL 711
Score = 55.1 bits (131), Expect = 5e-07
Identities = 35/112 (31%), Positives = 61/112 (54%), Gaps = 4/112 (3%)
Query: 524 RRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 583
+++D + L RA G L +V + ++ G +N + G LH A GH+ +V+ LL
Sbjct: 6 QKSDSNASFL-RAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLG 64
Query: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
G++VD +G T LH A G EV ++L++ GA++ +++ G +PL
Sbjct: 65 RGSSVDSATK---KGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPL 113
Score = 53.5 bits (127), Expect = 1e-06
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G++ N G T LH A EG V L+ +G ++ G T LH A + +
Sbjct: 631 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 690
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L HGA D G TPL A + G+ ++ LL++GA+V +T+ G +PL
Sbjct: 691 DILTKHGA---DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 747
Query: 639 QQ 640
Q
Sbjct: 748 AQ 749
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 81.6 bits (200), Expect = 5e-15
Identities = 71/265 (26%), Positives = 111/265 (41%), Gaps = 12/265 (4%)
Query: 381 LRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQAQR---PQLQRQVLQHL 437
L G+ ++ A N AL E++ ++ + Q+Q P H+
Sbjct: 84 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Query: 438 HTVQLRLQ--PQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGED 495
V+ L+ ++ TE L+VA + + + + ++ +D
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
Query: 496 DTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555
DT L+ D + NR + G T LH A G + L+ +G +
Sbjct: 204 DTKSAALLLQNDHNADV----QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Query: 556 NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615
+ G TPLH A G+ +V+ LLD G +D + +G+TPLH A GH +V E
Sbjct: 260 DFTARNGITPLHVASKRGNTNMVKLLLDRGGQID---AKTRDGLTPLHCAARSGHDQVVE 316
Query: 616 LLLERGASVTLRTRKGLSPLETLQQ 640
LLLERGA + RT+ GLSPL Q
Sbjct: 317 LLLERGAPLLARTKNGLSPLHMAAQ 341
Score = 77.4 bits (189), Expect = 9e-14
Identities = 60/164 (36%), Positives = 79/164 (48%), Gaps = 10/164 (6%)
Query: 499 GLTPQLEEDEELQGHLG-----RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
GLTP GHL + G+ + N GET LH A GQ+ V+ L+R G
Sbjct: 431 GLTPI--HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEV 613
++ R TPLH A G EIV+ LL H A P G TPLH + G +V
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMA---HPDAATTNGYTPLHISAREGQVDV 545
Query: 614 AELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKA 657
A +LLE GA+ +L T+KG +PL ++ L L L+ R A
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Score = 73.2 bits (178), Expect = 2e-12
Identities = 50/154 (32%), Positives = 77/154 (50%), Gaps = 16/154 (10%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
+G + + + G T LH A G + V+ L+ +G PL R G +PLH A H+E
Sbjct: 288 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLET 637
V+ LL H A VDD + +T LH A +CGH+ V +LLL++ A+ R G +PL
Sbjct: 348 VKHLLQHKAPVDD---VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
Query: 638 LQQWVKLYRRDLDLETRQKARAMEMLLQAAASGQ 671
+ + + + ME+L++ AS Q
Sbjct: 405 ACK-------------KNRIKVMELLVKYGASIQ 425
Score = 68.2 bits (165), Expect = 5e-11
Identities = 63/212 (29%), Positives = 88/212 (41%), Gaps = 33/212 (15%)
Query: 436 HLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGED 495
HL+ V L LQ +P+ T +R TA A AG+VE+
Sbjct: 443 HLNIVLLLLQNGASPDV-TNIR-----------------GETALHMAARAGQVEVVRCLL 484
Query: 496 DTDGLTPQLEEDEELQGHLGRRKGSKW------------NRRNDMGETLLHRACIEGQLR 543
L +E+ H+ R G + G T LH + EGQ+
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVD 544
Query: 544 RVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLH 603
L+ G + G+TPLH A YG L++ + LL AA D G G+TPLH
Sbjct: 545 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK---NGLTPLH 601
Query: 604 DALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
A + + +VA LLLE+GAS + G +PL
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPL 633
Score = 65.9 bits (159), Expect = 3e-10
Identities = 40/118 (33%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
KG+ + G T LH A E ++ L + G + G+TPL AC+YG++++
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
V FLL GA V+ + G TPLH A GH + +LL+ GA T G + L
Sbjct: 744 VNFLLKQGANVN---AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 65.5 bits (158), Expect = 3e-10
Identities = 49/154 (31%), Positives = 69/154 (44%), Gaps = 3/154 (1%)
Query: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
N N G LH A EG + VQ+L+ +G ++ G T LH A G E+V+ L+
Sbjct: 58 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
Query: 583 DHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWV 642
GA ++ Q G TPL+ A H +V + LLE GA+ + T G +PL Q
Sbjct: 118 KEGANIN---AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 643 KLYRRDLDLETRQKARAMEMLLQAAASGQDPHSS 676
+ LE K + L AA D S+
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Score = 65.5 bits (158), Expect = 3e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 8/122 (6%)
Query: 511 QGHLGR-----RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTP 565
+GH+G +GS + G T LH A + GQ V+ LV++G +N + G+TP
Sbjct: 74 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTP 133
Query: 566 LHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVT 625
L+ A H+++V++LL++GA + +G TPL AL GH + +LLE
Sbjct: 134 LYMAAQENHIDVVKYLLENGA---NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 626 LR 627
+R
Sbjct: 191 VR 192
Score = 65.5 bits (158), Expect = 3e-10
Identities = 43/113 (38%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
N R G T LH AC + +++ ++ LV+ G + G TP+H A GHL IV LL
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 583 DHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+GA+ P G T LH A G EV LL GA V R R+ +PL
Sbjct: 452 QNGAS---PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Score = 59.7 bits (143), Expect = 2e-08
Identities = 39/124 (31%), Positives = 57/124 (45%), Gaps = 3/124 (2%)
Query: 505 EEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWT 564
+ED+ + + G+ + +G T L AC G ++ V L++QG +N + G+T
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763
Query: 565 PLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASV 624
PLH+A GH I+ LL HGA P G T L A G+ V + L V
Sbjct: 764 PLHQAAQQGHTHIINVLLQHGA---KPNATTANGNTALAIAKRLGYISVVDTLKVVTEEV 820
Query: 625 TLRT 628
T T
Sbjct: 821 TTTT 824
Score = 58.9 bits (141), Expect = 3e-08
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 7/131 (5%)
Query: 505 EEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWT 564
+ E+ G RRK K ++D + L RA G L +V + ++ G +N + G
Sbjct: 11 DSGEKFNGSSQRRKRPK---KSDSNASFL-RAARAGNLDKVVEYLKGGIDINTCNQNGLN 66
Query: 565 PLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASV 624
LH A GH+ +V+ LL G++VD +G T LH A G EV ++L++ GA++
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSATK---KGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 625 TLRTRKGLSPL 635
+++ G +PL
Sbjct: 124 NAQSQNGFTPL 134
Score = 56.6 bits (135), Expect = 2e-07
Identities = 39/121 (32%), Positives = 61/121 (50%), Gaps = 3/121 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH A + L+ +G + G+TPLH A ++I LL++GA
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRD 648
+ QG +TPLH A GH ++ LLL++GA++ + T+ GL+ L Q K+ D
Sbjct: 656 NIVTKQG---VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 712
Query: 649 L 649
+
Sbjct: 713 I 713
Score = 55.5 bits (132), Expect = 4e-07
Identities = 45/141 (31%), Positives = 62/141 (43%), Gaps = 6/141 (4%)
Query: 498 DGLTP---QLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHP 554
+GLTP D + L KG+ + G T LH A + Q++ L+ G
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Query: 555 LNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVA 614
N G TPLH A GH ++V LLD GA + G+T LH A VA
Sbjct: 655 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH---MSTKSGLTSLHLAAQEDKVNVA 711
Query: 615 ELLLERGASVTLRTRKGLSPL 635
++L + GA T+ G +PL
Sbjct: 712 DILTKHGADQDAHTKLGYTPL 732
Score = 53.5 bits (127), Expect = 1e-06
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G++ N G T LH A EG V L+ +G ++ G T LH A + +
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L HGA D G TPL A + G+ ++ LL++GA+V +T+ G +PL
Sbjct: 712 DILTKHGA---DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 639 QQ 640
Q
Sbjct: 769 AQ 770
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 81.6 bits (200), Expect = 5e-15
Identities = 71/265 (26%), Positives = 111/265 (41%), Gaps = 12/265 (4%)
Query: 381 LRSGNVLEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQAQR---PQLQRQVLQHL 437
L G+ ++ A N AL E++ ++ + Q+Q P H+
Sbjct: 84 LGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHI 143
Query: 438 HTVQLRLQ--PQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGED 495
V+ L+ ++ TE L+VA + + + + ++ +D
Sbjct: 144 DVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKD 203
Query: 496 DTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555
DT L+ D + NR + G T LH A G + L+ +G +
Sbjct: 204 DTKSAALLLQNDHNADV----QSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAV 259
Query: 556 NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615
+ G TPLH A G+ +V+ LLD G +D + +G+TPLH A GH +V E
Sbjct: 260 DFTARNGITPLHVASKRGNTNMVKLLLDRGGQID---AKTRDGLTPLHCAARSGHDQVVE 316
Query: 616 LLLERGASVTLRTRKGLSPLETLQQ 640
LLLERGA + RT+ GLSPL Q
Sbjct: 317 LLLERGAPLLARTKNGLSPLHMAAQ 341
Score = 77.4 bits (189), Expect = 9e-14
Identities = 60/164 (36%), Positives = 79/164 (48%), Gaps = 10/164 (6%)
Query: 499 GLTPQLEEDEELQGHLG-----RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
GLTP GHL + G+ + N GET LH A GQ+ V+ L+R G
Sbjct: 431 GLTPI--HVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEV 613
++ R TPLH A G EIV+ LL H A P G TPLH + G +V
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMA---HPDAATTNGYTPLHISAREGQVDV 545
Query: 614 AELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKA 657
A +LLE GA+ +L T+KG +PL ++ L L L+ R A
Sbjct: 546 ASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Score = 73.2 bits (178), Expect = 2e-12
Identities = 50/154 (32%), Positives = 77/154 (50%), Gaps = 16/154 (10%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
+G + + + G T LH A G + V+ L+ +G PL R G +PLH A H+E
Sbjct: 288 RGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVEC 347
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLET 637
V+ LL H A VDD + +T LH A +CGH+ V +LLL++ A+ R G +PL
Sbjct: 348 VKHLLQHKAPVDD---VTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHI 404
Query: 638 LQQWVKLYRRDLDLETRQKARAMEMLLQAAASGQ 671
+ + + + ME+L++ AS Q
Sbjct: 405 ACK-------------KNRIKVMELLVKYGASIQ 425
Score = 68.2 bits (165), Expect = 5e-11
Identities = 63/212 (29%), Positives = 88/212 (41%), Gaps = 33/212 (15%)
Query: 436 HLHTVQLRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGED 495
HL+ V L LQ +P+ T +R TA A AG+VE+
Sbjct: 443 HLNIVLLLLQNGASPDV-TNIR-----------------GETALHMAARAGQVEVVRCLL 484
Query: 496 DTDGLTPQLEEDEELQGHLGRRKGSKW------------NRRNDMGETLLHRACIEGQLR 543
L +E+ H+ R G + G T LH + EGQ+
Sbjct: 485 RNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVD 544
Query: 544 RVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLH 603
L+ G + G+TPLH A YG L++ + LL AA D G G+TPLH
Sbjct: 545 VASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGK---NGLTPLH 601
Query: 604 DALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
A + + +VA LLLE+GAS + G +PL
Sbjct: 602 VAAHYDNQKVALLLLEKGASPHATAKNGYTPL 633
Score = 65.9 bits (159), Expect = 3e-10
Identities = 40/118 (33%), Positives = 58/118 (49%), Gaps = 3/118 (2%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
KG+ + G T LH A E ++ L + G + G+TPL AC+YG++++
Sbjct: 684 KGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKM 743
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
V FLL GA V+ + G TPLH A GH + +LL+ GA T G + L
Sbjct: 744 VNFLLKQGANVN---AKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTAL 798
Score = 65.5 bits (158), Expect = 3e-10
Identities = 49/154 (31%), Positives = 69/154 (44%), Gaps = 3/154 (1%)
Query: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
N N G LH A EG + VQ+L+ +G ++ G T LH A G E+V+ L+
Sbjct: 58 NTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLV 117
Query: 583 DHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWV 642
GA ++ Q G TPL+ A H +V + LLE GA+ + T G +PL Q
Sbjct: 118 KEGANIN---AQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQG 174
Query: 643 KLYRRDLDLETRQKARAMEMLLQAAASGQDPHSS 676
+ LE K + L AA D S+
Sbjct: 175 HNQAVAILLENDTKGKVRLPALHIAARKDDTKSA 208
Score = 65.5 bits (158), Expect = 3e-10
Identities = 40/122 (32%), Positives = 64/122 (52%), Gaps = 8/122 (6%)
Query: 511 QGHLGR-----RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTP 565
+GH+G +GS + G T LH A + GQ V+ LV++G +N + G+TP
Sbjct: 74 EGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTP 133
Query: 566 LHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVT 625
L+ A H+++V++LL++GA + +G TPL AL GH + +LLE
Sbjct: 134 LYMAAQENHIDVVKYLLENGA---NQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGK 190
Query: 626 LR 627
+R
Sbjct: 191 VR 192
Score = 65.5 bits (158), Expect = 3e-10
Identities = 43/113 (38%), Positives = 56/113 (49%), Gaps = 3/113 (2%)
Query: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
N R G T LH AC + +++ ++ LV+ G + G TP+H A GHL IV LL
Sbjct: 392 NARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLL 451
Query: 583 DHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+GA+ P G T LH A G EV LL GA V R R+ +PL
Sbjct: 452 QNGAS---PDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPL 501
Score = 59.7 bits (143), Expect = 2e-08
Identities = 39/124 (31%), Positives = 57/124 (45%), Gaps = 3/124 (2%)
Query: 505 EEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWT 564
+ED+ + + G+ + +G T L AC G ++ V L++QG +N + G+T
Sbjct: 704 QEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYT 763
Query: 565 PLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASV 624
PLH+A GH I+ LL HGA P G T L A G+ V + L V
Sbjct: 764 PLHQAAQQGHTHIINVLLQHGA---KPNATTANGNTALAIAKRLGYISVVDTLKVVTEEV 820
Query: 625 TLRT 628
T T
Sbjct: 821 TTTT 824
Score = 58.9 bits (141), Expect = 3e-08
Identities = 41/131 (31%), Positives = 68/131 (51%), Gaps = 7/131 (5%)
Query: 505 EEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWT 564
+ E+ G RRK K ++D + L RA G L +V + ++ G +N + G
Sbjct: 11 DSGEKFNGSSQRRKRPK---KSDSNASFL-RAARAGNLDKVVEYLKGGIDINTCNQNGLN 66
Query: 565 PLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASV 624
LH A GH+ +V+ LL G++VD +G T LH A G EV ++L++ GA++
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSSVDSATK---KGNTALHIASLAGQAEVVKVLVKEGANI 123
Query: 625 TLRTRKGLSPL 635
+++ G +PL
Sbjct: 124 NAQSQNGFTPL 134
Score = 56.6 bits (135), Expect = 2e-07
Identities = 39/121 (32%), Positives = 61/121 (50%), Gaps = 3/121 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH A + L+ +G + G+TPLH A ++I LL++GA
Sbjct: 596 GLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAET 655
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRD 648
+ QG +TPLH A GH ++ LLL++GA++ + T+ GL+ L Q K+ D
Sbjct: 656 NIVTKQG---VTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 712
Query: 649 L 649
+
Sbjct: 713 I 713
Score = 55.5 bits (132), Expect = 4e-07
Identities = 45/141 (31%), Positives = 62/141 (43%), Gaps = 6/141 (4%)
Query: 498 DGLTP---QLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHP 554
+GLTP D + L KG+ + G T LH A + Q++ L+ G
Sbjct: 595 NGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAE 654
Query: 555 LNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVA 614
N G TPLH A GH ++V LLD GA + G+T LH A VA
Sbjct: 655 TNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIH---MSTKSGLTSLHLAAQEDKVNVA 711
Query: 615 ELLLERGASVTLRTRKGLSPL 635
++L + GA T+ G +PL
Sbjct: 712 DILTKHGADQDAHTKLGYTPL 732
Score = 53.5 bits (127), Expect = 1e-06
Identities = 38/122 (31%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G++ N G T LH A EG V L+ +G ++ G T LH A + +
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVA 711
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L HGA D G TPL A + G+ ++ LL++GA+V +T+ G +PL
Sbjct: 712 DILTKHGA---DQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQA 768
Query: 639 QQ 640
Q
Sbjct: 769 AQ 770
Score = 44.7 bits (104), Expect = 6e-04
Identities = 47/197 (23%), Positives = 81/197 (41%), Gaps = 16/197 (8%)
Query: 633 SPLETLQQWVKLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTP---SSLLFDP 689
+P+ +++ VK ++ + E QK R+ L G++ + H P +S
Sbjct: 1761 TPIGSIKDKVKALQKRV--EDEQKGRSK---LPIRVKGKEDVPKKTTHRPHPAASPSLKS 1815
Query: 690 ETSPPLSPCPEPPSNSTRLPEA-SQAHVRVSPGQA----APAMARPRRSRHGPASSSSSS 744
E P SP P+ +ST A ++ H VSP +P + RH PASSSS +
Sbjct: 1816 ERHAPGSPSPKTERHSTLSSSAKTERHPPVSPSSKTEKHSPVSPSAKTERHSPASSSSKT 1875
Query: 745 EGEDSAGPARPSQKR-PRCSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQ 803
E P+ +++ P S +R +P +++ + + R + G +
Sbjct: 1876 EKHSPVSPSTKTERHSPVSSTKTERHPPVSPSGKTDKRPPVSPSGRTEKHPPV-SPGRTE 1934
Query: 804 SRLGPGPPRGHSKALAP 820
RL P P G + P
Sbjct: 1935 KRL-PVSPSGRTDKHQP 1950
Score = 36.6 bits (83), Expect = 0.17
Identities = 26/99 (26%), Positives = 43/99 (43%), Gaps = 5/99 (5%)
Query: 673 PHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTRLPEA-SQAHVRVSPGQAA---PAMA 728
P + H+P S E PP+SP + P ++ H VSPG+ P
Sbjct: 1883 PSTKTERHSPVSST-KTERHPPVSPSGKTDKRPPVSPSGRTEKHPPVSPGRTEKRLPVSP 1941
Query: 729 RPRRSRHGPASSSSSSEGEDSAGPARPSQKRPRCSATAQ 767
R +H P S++ +E P+ ++K+P S T++
Sbjct: 1942 SGRTDKHQPVSTAGKTEKHLPVSPSGKTEKQPPVSPTSK 1980
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 80.5 bits (197), Expect = 1e-14
Identities = 61/178 (34%), Positives = 83/178 (46%), Gaps = 12/178 (6%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ N N GET LH A GQ V+ LV+ G + + TPLH + G +IV
Sbjct: 456 GASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIV 515
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
+ LL GA+ P G TPLH + GH +VA LL+ GAS+++ T+KG +PL
Sbjct: 516 QQLLQQGAS---PNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572
Query: 639 QQWVKLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPSS---LLFDPETSP 693
++ KL +L L+ A A SG P A + LL D SP
Sbjct: 573 AKYGKLEVANLLLQKSASPDA------AGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Score = 73.6 bits (179), Expect = 1e-12
Identities = 43/113 (38%), Positives = 60/113 (53%), Gaps = 3/113 (2%)
Query: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
N N G T LH A E ++ + LV QG ++ + G+TPLH C+YG+++IV FLL
Sbjct: 691 NLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLL 750
Query: 583 DHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
H A V+ + G TPLH A GH + +LL+ AS T G + L
Sbjct: 751 QHSAKVN---AKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTAL 800
Score = 68.6 bits (166), Expect = 4e-11
Identities = 46/154 (29%), Positives = 76/154 (49%), Gaps = 16/154 (10%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
+G+K + + G T LH G + V+ L+ + P+ + G +PLH A HL
Sbjct: 290 RGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNC 349
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLET 637
V+ LL H VDD + +T LH A +CGH++VA++LL++ A+ + G +PL
Sbjct: 350 VQLLLQHNVPVDDVTN---DYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHI 406
Query: 638 LQQWVKLYRRDLDLETRQKARAMEMLLQAAASGQ 671
+ + + + ME+LL+ AS Q
Sbjct: 407 ACK-------------KNRIKVMELLLKHGASIQ 427
Score = 68.2 bits (165), Expect = 5e-11
Identities = 67/268 (25%), Positives = 109/268 (40%), Gaps = 21/268 (7%)
Query: 378 ELRLRSGNV---LEEAKTWLNIALSREEAGDAYELLAPCFQKALSCAQQAQRPQLQRQVL 434
EL R NV ++ T L+IA +A + ++L + +Q P
Sbjct: 92 ELLQREANVDAATKKGNTALHIASLAGQA-EVVKVLVTNGANVNAQSQNGFTPLYMAAQE 150
Query: 435 QHLHTVQLRLQ--PQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSE 492
HL V+ L ++ TE L+VA + ++ + + ++
Sbjct: 151 NHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAA 210
Query: 493 GEDDTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQG 552
+DDT L+ D + + G T LH A G + L+ +
Sbjct: 211 RKDDTKAAALLLQNDNNA------------DVESKSGFTPLHIAAHYGNINVATLLLNRA 258
Query: 553 HPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFE 612
++ TPLH A G+ +V+ LLD GA +D + +G+TPLH GH +
Sbjct: 259 AAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKID---AKTRDGLTPLHCGARSGHEQ 315
Query: 613 VAELLLERGASVTLRTRKGLSPLETLQQ 640
V E+LL+R A + +T+ GLSPL Q
Sbjct: 316 VVEMLLDRAAPILSKTKNGLSPLHMATQ 343
Score = 67.8 bits (164), Expect = 7e-11
Identities = 62/198 (31%), Positives = 90/198 (45%), Gaps = 21/198 (10%)
Query: 442 LRLQPQEAPETETRLRELSVAEDEDEEEEAEEAAATAESEALEAGEVELSEGED----DT 497
L + +E PE + + R+ S + + A A A + LE + G D +
Sbjct: 14 LEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRA-ARAGHLEKALDYIKNGVDINICNQ 72
Query: 498 DGLTP----QLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
+GL E E+ L +R+ + + G T LH A + GQ V+ LV G
Sbjct: 73 NGLNALHLASKEGHVEVVSELLQREANV-DAATKKGNTALHIASLAGQAEVVKVLVTNGA 131
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA----AVDDPGGQGCEGITPLHDALNCG 609
+N + G+TPL+ A HLE+V+FLLD+GA A +D G TPL AL G
Sbjct: 132 NVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATED-------GFTPLAVALQQG 184
Query: 610 HFEVAELLLERGASVTLR 627
H +V LLLE +R
Sbjct: 185 HDQVVSLLLENDTKGKVR 202
Score = 67.8 bits (164), Expect = 7e-11
Identities = 59/206 (28%), Positives = 96/206 (46%), Gaps = 19/206 (9%)
Query: 474 AAATAESEAL-----EAGEVELSEGEDDTD-GLTPQLEEDEELQGHLGRRKGSKWNRRND 527
AA + ++E + + +VE +D T ++ +L + + +Q L ++G+ N
Sbjct: 473 AARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLL--QQGASPNAATT 530
Query: 528 MGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAA 587
G T LH + EG L+ G L+ G+TPLH A YG LE+ LL A+
Sbjct: 531 SGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSAS 590
Query: 588 VDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKL--- 644
P G G+TPLH A + + +VA LLL++GAS + G +PL + ++
Sbjct: 591 ---PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA 647
Query: 645 -----YRRDLDLETRQKARAMEMLLQ 665
Y D + TRQ ++ + Q
Sbjct: 648 TTLLEYGADANAVTRQGIASVHLAAQ 673
Score = 60.5 bits (145), Expect = 1e-08
Identities = 36/107 (33%), Positives = 54/107 (50%), Gaps = 3/107 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH AC + +++ ++ L++ G + G TP+H A GH+ IV L+ HGA+
Sbjct: 400 GFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGAS- 458
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
P G T LH A G EV L++ GA V + + +PL
Sbjct: 459 --PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPL 503
Score = 58.2 bits (139), Expect = 5e-08
Identities = 37/122 (30%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ N G +H A EG + V L+ + +N + G TPLH A + +
Sbjct: 654 GADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVA 713
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L++ GA VD Q G TPLH + G+ ++ LL+ A V +T+ G +PL
Sbjct: 714 EVLVNQGAHVD---AQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQA 770
Query: 639 QQ 640
Q
Sbjct: 771 AQ 772
Score = 57.4 bits (137), Expect = 9e-08
Identities = 48/172 (27%), Positives = 78/172 (45%), Gaps = 15/172 (8%)
Query: 499 GLTP---QLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPL 555
GLTP +ED + +G+ + + MG T LH C G ++ V L++ +
Sbjct: 697 GLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKV 756
Query: 556 NPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAE 615
N + G+TPLH+A GH I+ LL + A+ P G T L A G+ V +
Sbjct: 757 NAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS---PNELTVNGNTALGIARRLGYISVVD 813
Query: 616 LLL----ERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLETRQKARAMEML 663
L E + T+ + ++ ET+ + + D+ + +KA A EML
Sbjct: 814 TLKIVTEETMTTTTVTEKHKMNVPETMNEVL-----DMSDDEVRKANAPEML 860
Score = 55.1 bits (131), Expect = 5e-07
Identities = 59/246 (23%), Positives = 101/246 (41%), Gaps = 26/246 (10%)
Query: 415 QKALSCAQQAQRPQLQRQVLQHLHTVQLRLQPQEAP-ETETRLRELSVAEDEDEEEEAEE 473
+ AL A ++ + ++ R ++Q V+ + + + P RL + + + ++ +
Sbjct: 467 ETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPN 526
Query: 474 AAATAESEALEAGEVELSEGEDDT----------------DGLTP---QLEEDEELQGHL 514
AA T+ L + EG +D G TP + + +L
Sbjct: 527 AATTSGYTPLH---LSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANL 583
Query: 515 GRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGH 574
+K + + G T LH A + L+ QG + G+TPLH A
Sbjct: 584 LLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQ 643
Query: 575 LEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSP 634
++I LL++GA D +GI +H A GH ++ LLL R A+V L + GL+P
Sbjct: 644 MDIATTLLEYGA---DANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTP 700
Query: 635 LETLQQ 640
L Q
Sbjct: 701 LHLAAQ 706
Score = 33.1 bits (74), Expect = 1.9
Identities = 23/67 (34%), Positives = 32/67 (47%), Gaps = 3/67 (4%)
Query: 569 ACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRT 628
A GHLE + +G ++ G + LH A GH EV LL+R A+V T
Sbjct: 48 AARAGHLEKALDYIKNGVDINICNQNG---LNALHLASKEGHVEVVSELLQREANVDAAT 104
Query: 629 RKGLSPL 635
+KG + L
Sbjct: 105 KKGNTAL 111
>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase 2 [Homo sapiens]
Length = 1166
Score = 78.2 bits (191), Expect = 5e-14
Identities = 66/210 (31%), Positives = 97/210 (46%), Gaps = 21/210 (10%)
Query: 474 AAATAESEALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRKGSKWNRRNDMGE--T 531
A A+A +EA+E EL E + D +E + L K N R+ G T
Sbjct: 12 ACASAAAEAVEPAARELFEACRNGD-----VERVKRLV------TPEKVNSRDTAGRKST 60
Query: 532 LLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDP 591
LH A G+ V+ L++ G + RD G PLH AC++GH E+V LL HGA DP
Sbjct: 61 PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGA---DP 117
Query: 592 GGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKL-----YR 646
+ TPLH+A G +V +LL+ GA T+R G + L+ K Y+
Sbjct: 118 NARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYK 177
Query: 647 RDLDLETRQKARAMEMLLQAAASGQDPHSS 676
+D LE+ + +M+ + H+S
Sbjct: 178 KDELLESARSGNEEKMMALLTPLNVNCHAS 207
Score = 77.4 bits (189), Expect = 9e-14
Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 11/140 (7%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A ++ V+ L++ G ++ +D G PLH AC+YGH E+ L+ HGA V+
Sbjct: 528 TPLHFAAGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN- 586
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLD 650
TPLH+A G +E+ +LLL+ GA T + R G +PL+ + +D D
Sbjct: 587 --VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLV--------KDGD 636
Query: 651 LETRQKARAMEMLLQAAASG 670
+ + R LL AA G
Sbjct: 637 TDIQDLLRGDAALLDAAKKG 656
Score = 70.5 bits (171), Expect = 1e-11
Identities = 68/218 (31%), Positives = 93/218 (42%), Gaps = 28/218 (12%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGW--TPLHEACNYGHLEIVRFLLDHGA 586
G+ L A +G L RV+ L + +N RD G TPLH A Y +LE+ +LL HGA
Sbjct: 645 GDAALLDAAKKGCLARVKKLSSPDN-VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGA 703
Query: 587 AVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYR 646
D Q G+ PLH+A + GH +VA LL++ A V + +PL
Sbjct: 704 ---DVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLH---------- 750
Query: 647 RDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNST 706
E QK R L A +Q TP L+ + S L+ PPS
Sbjct: 751 -----EAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLT-AAMPPSALP 804
Query: 707 RLPEASQAHVRVSPGQAAPAMARPRRSRHGPASSSSSS 744
+ + SPG A A++ GP+S SS S
Sbjct: 805 SCYKPQVLNGVRSPGATADALS------SGPSSPSSLS 836
Score = 65.1 bits (157), Expect = 4e-10
Identities = 39/116 (33%), Positives = 60/116 (51%), Gaps = 5/116 (4%)
Query: 523 NRRNDMGE--TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRF 580
N R+ G T LH A L + L++ G +N +D G PLH A +YGH+++
Sbjct: 671 NCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAAL 730
Query: 581 LLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
L+ + A V+ TPLH+A G ++ LLL GA TL+ ++G +PL+
Sbjct: 731 LIKYNACVN---ATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLD 783
Score = 64.3 bits (155), Expect = 8e-10
Identities = 37/96 (38%), Positives = 51/96 (53%), Gaps = 3/96 (3%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A +++ VQ L++ G ++ +D PLH AC+YGH E+ L+ HGA V+
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNACSYGHYEVTELLVKHGACVN- 271
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTL 626
TPLH+A + EV LLL GA TL
Sbjct: 272 --AMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTL 305
Score = 55.1 bits (131), Expect = 5e-07
Identities = 32/74 (43%), Positives = 42/74 (56%), Gaps = 7/74 (9%)
Query: 564 TPLHEACNYGHLEIVRFLLDHGAAVD--DPGGQGCEGITPLHDALNCGHFEVAELLLERG 621
TPLH A Y ++IV+ LL HGA V D G + PLH+A + GH+EV ELL++ G
Sbjct: 213 TPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD-----LVPLHNACSYGHYEVTELLVKHG 267
Query: 622 ASVTLRTRKGLSPL 635
A V +PL
Sbjct: 268 ACVNAMDLWQFTPL 281
Score = 52.0 bits (123), Expect = 4e-06
Identities = 43/143 (30%), Positives = 65/143 (45%), Gaps = 18/143 (12%)
Query: 530 ETLLHRACIEGQLRRVQD---LVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA 586
ET LH A +R Q L+R+G +N + TPLH A H ++V ++ H A
Sbjct: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEA 424
Query: 587 AVD--DPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL--------E 636
V+ D GQ T LH A CGH + LLL G + + +G + L +
Sbjct: 425 KVNALDNLGQ-----TSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQ 479
Query: 637 TLQQWVKLYRRDLDLETRQKARA 659
LQ+ + L + D + + A+A
Sbjct: 480 LLQEGISLGNSEADRQLLEAAKA 502
Score = 44.7 bits (104), Expect = 6e-04
Identities = 35/103 (33%), Positives = 47/103 (45%), Gaps = 7/103 (6%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
RKG+ N + T LH A + V+ +V+ +N D G T LH A GHL+
Sbjct: 388 RKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQ 447
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLE 619
R LL +G DP +G T AL G+ V +LL E
Sbjct: 448 TCRLLLSYGC---DPNIISLQGFT----ALQMGNENVQQLLQE 483
Score = 43.9 bits (102), Expect = 0.001
Identities = 29/84 (34%), Positives = 40/84 (47%), Gaps = 3/84 (3%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ N ++ G LH A G + L++ +N D +TPLHEA G ++
Sbjct: 702 GADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLC 761
Query: 579 RFLLDHGAAVDDPGGQGCEGITPL 602
LL HGA DP + EG TPL
Sbjct: 762 ALLLAHGA---DPTLKNQEGQTPL 782
>gi|194018403 ankyrin repeat domain 2 isoform b [Homo sapiens]
Length = 327
Score = 76.3 bits (186), Expect = 2e-13
Identities = 40/111 (36%), Positives = 62/111 (55%), Gaps = 3/111 (2%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LHRA +EG + ++ L+ G ++ +D T +H AC GHLE+V+ L HGA D
Sbjct: 183 TALHRASLEGHMEILEKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGA---D 239
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQW 641
+ EG T LHDA+ +++ +LLL GA + + G +P + +Q W
Sbjct: 240 TNVRDKEGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTPTDLVQLW 290
Score = 60.8 bits (146), Expect = 8e-09
Identities = 37/102 (36%), Positives = 54/102 (52%), Gaps = 4/102 (3%)
Query: 530 ETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVD 589
ET L +A +EG+++ ++ + G + D T LH A GH+EI+ LLD+GA VD
Sbjct: 150 ETFL-KAAVEGKMKVIEKFLADGGSADTCDQFRRTALHRASLEGHMEILEKLLDNGATVD 208
Query: 590 DPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKG 631
C T +H A GH EV +LL GA +R ++G
Sbjct: 209 FQDRLDC---TAMHWACRGGHLEVVKLLQSHGADTNVRDKEG 247
>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 75.5 bits (184), Expect = 3e-13
Identities = 51/173 (29%), Positives = 85/173 (49%), Gaps = 11/173 (6%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
K K + D G L AC G V L+ +G +N + G T LH+AC ++++
Sbjct: 30 KRQKTKVKFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDM 88
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLET 637
V+FL+++GA ++ P EG PLH A +CG+ ++AE L+ +GA V +G +PL+
Sbjct: 89 VKFLVENGANINQPDN---EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDI 145
Query: 638 LQQWV-------KLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPS 683
++ ++ R+ +D+E +K ML A H + H S
Sbjct: 146 AEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKS 198
Score = 60.8 bits (146), Expect = 8e-09
Identities = 79/347 (22%), Positives = 136/347 (39%), Gaps = 69/347 (19%)
Query: 470 EAEEAAATAESEALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRKGSKW---NRRN 526
E + AE EA+E EL + E + G+ + EE + L R +W N
Sbjct: 138 EGDTPLDIAEEEAME----ELLQNEVNRQGVDIEAARKEEERIML--RDARQWLNSGHIN 191
Query: 527 DM-----GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFL 581
D+ G T LH A +G ++ L++ G+ +N +DY GWTPLH A ++G E R L
Sbjct: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251
Query: 582 LDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQW 641
+D+ ++ + + + F+VA+ L LE LQ+
Sbjct: 252 VDNLCDME------------MVNKVGQTAFDVAD-------------EDILGYLEELQKK 286
Query: 642 VKLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEP 701
L L E R K L+++ A+ + S + F +L+ +PE
Sbjct: 287 QNL----LHSEKRDK---KSPLIESTANMDNNQSQKTFKNKETLIIEPE----------- 328
Query: 702 PSNSTRLPEASQAHVRVSPGQAAPAMARPRRSRHGPASSSSSSEGEDSAGPARPSQKRPR 761
N++R+ Q V + + SS E +DS A + +P
Sbjct: 329 -KNASRIESLEQEKVD----------EEEEGKKDESSCSSEEDEEDDSESEAETDKTKPL 377
Query: 762 CSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGP 808
S T ++ P + T S+ +A + I+ + +++ P
Sbjct: 378 ASVTNANTSSTQAAPVA-VTTPTVSSGQATPTSPIKKFPTTATKISP 423
>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
12A isoform a [Homo sapiens]
Length = 1030
Score = 75.5 bits (184), Expect = 3e-13
Identities = 51/173 (29%), Positives = 85/173 (49%), Gaps = 11/173 (6%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
K K + D G L AC G V L+ +G +N + G T LH+AC ++++
Sbjct: 30 KRQKTKVKFDDGAVFL-AACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDM 88
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLET 637
V+FL+++GA ++ P EG PLH A +CG+ ++AE L+ +GA V +G +PL+
Sbjct: 89 VKFLVENGANINQPDN---EGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDI 145
Query: 638 LQQWV-------KLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPS 683
++ ++ R+ +D+E +K ML A H + H S
Sbjct: 146 AEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKS 198
Score = 60.8 bits (146), Expect = 8e-09
Identities = 79/347 (22%), Positives = 136/347 (39%), Gaps = 69/347 (19%)
Query: 470 EAEEAAATAESEALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRKGSKW---NRRN 526
E + AE EA+E EL + E + G+ + EE + L R +W N
Sbjct: 138 EGDTPLDIAEEEAME----ELLQNEVNRQGVDIEAARKEEERIML--RDARQWLNSGHIN 191
Query: 527 DM-----GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFL 581
D+ G T LH A +G ++ L++ G+ +N +DY GWTPLH A ++G E R L
Sbjct: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251
Query: 582 LDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQW 641
+D+ ++ + + + F+VA+ L LE LQ+
Sbjct: 252 VDNLCDME------------MVNKVGQTAFDVAD-------------EDILGYLEELQKK 286
Query: 642 VKLYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEP 701
L L E R K L+++ A+ + S + F +L+ +PE
Sbjct: 287 QNL----LHSEKRDK---KSPLIESTANMDNNQSQKTFKNKETLIIEPE----------- 328
Query: 702 PSNSTRLPEASQAHVRVSPGQAAPAMARPRRSRHGPASSSSSSEGEDSAGPARPSQKRPR 761
N++R+ Q V + + SS E +DS A + +P
Sbjct: 329 -KNASRIESLEQEKVD----------EEEEGKKDESSCSSEEDEEDDSESEAETDKTKPL 377
Query: 762 CSATAQRVAAWTPGPASNREAATASTSRAAYQAAIRGVGSAQSRLGP 808
S T ++ P + T S+ +A + I+ + +++ P
Sbjct: 378 ASVTNANTSSTQAAPVA-VTTPTVSSGQATPTSPIKKFPTTATKISP 423
>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
polymerase [Homo sapiens]
Length = 1327
Score = 75.5 bits (184), Expect = 3e-13
Identities = 47/140 (33%), Positives = 72/140 (51%), Gaps = 11/140 (7%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A ++ V+ L+ G ++ +D G PLH AC+YGH E+ L+ HGA+V+
Sbjct: 686 TPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVN- 744
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLD 650
TPLH+A G +E+ +LLL+ GA T + R G +PL+ +++ D
Sbjct: 745 --VADLWKFTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDLVKEG--------D 794
Query: 651 LETRQKARAMEMLLQAAASG 670
+ + R LL AA G
Sbjct: 795 TDIQDLLRGDAALLDAAKKG 814
Score = 71.2 bits (173), Expect = 6e-12
Identities = 42/106 (39%), Positives = 56/106 (52%), Gaps = 3/106 (2%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A ++R VQ L++ G ++ +D G PLH AC+YGH E+ LL HGA V+
Sbjct: 371 TPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVN- 429
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
TPLH+A + EV LLL GA TL G S ++
Sbjct: 430 --AMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVD 473
Score = 70.1 bits (170), Expect = 1e-11
Identities = 62/218 (28%), Positives = 95/218 (43%), Gaps = 15/218 (6%)
Query: 470 EAEEAAATAESEALEAGEVELSEGEDDTDGLTPQLEEDEELQGHLGRRK----GSKWNRR 525
E+ EAA + + L G G G +L E G + R K + N +
Sbjct: 152 ESPEAAGVSSTAPLGPGAAGPGTGVPAVSGALRELLEACR-NGDVSRVKRLVDAANVNAK 210
Query: 526 NDMGE--TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 583
+ G + LH A G+ V+ L++ G ++ RD G PLH AC++GH E+V LL
Sbjct: 211 DMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDDGGLIPLHNACSFGHAEVVSLLLC 270
Query: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVK 643
GA DP + TPLH+A G +V +LL+ GA +R G S L+ K
Sbjct: 271 QGA---DPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGADPNIRNTDGKSALDLADPSAK 327
Query: 644 L-----YRRDLDLETRQKARAMEMLLQAAASGQDPHSS 676
Y++D LE + +++ + H+S
Sbjct: 328 AVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHAS 365
Score = 65.1 bits (157), Expect = 4e-10
Identities = 83/302 (27%), Positives = 117/302 (38%), Gaps = 58/302 (19%)
Query: 473 EAAATAESEALEAGEVELSEGEDDT----DGLTPQ---LEEDEELQGHLGRRKGSKWNRR 525
EAAA + E + + L G D T DG TP E D ++Q L
Sbjct: 756 EAAAKGKYEICK---LLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLL----------- 801
Query: 526 NDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGW--TPLHEACNYGHLEIVRFLLD 583
G+ L A +G L RVQ L + +N RD G TPLH A Y +LE+ +LL+
Sbjct: 802 --RGDAALLDAAKKGCLARVQKLCTPEN-INCRDTQGRNSTPLHLAAGYNNLEVAEYLLE 858
Query: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVK 643
HGA D Q G+ PLH+A + GH ++A LL++ V + +PL
Sbjct: 859 HGA---DVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLH------- 908
Query: 644 LYRRDLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTP---------SSLLFDPETSPP 694
E QK R L A +Q TP +LL D
Sbjct: 909 --------EAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEA 960
Query: 695 LSPCPEPPSN--STRLPEASQAHVRVSPGQAAPAMARPRRSRHGPASSSSSSEGEDSAGP 752
L C +P + S L + +S + + P A +S+ G+ +AG
Sbjct: 961 LPTCFKPQATVVSASLISPASTPSCLSAASSIDNLTGPLAEL---AVGGASNAGDGAAGT 1017
Query: 753 AR 754
R
Sbjct: 1018 ER 1019
Score = 59.3 bits (142), Expect = 2e-08
Identities = 50/168 (29%), Positives = 63/168 (37%), Gaps = 51/168 (30%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ + ++ G LH AC G + LVR G +N D +TPLHEA G EI
Sbjct: 707 GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEIC 766
Query: 579 RFLLDHG-------------------------------AAVDDPGGQGC----------- 596
+ LL HG AA+ D +GC
Sbjct: 767 KLLLKHGADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPE 826
Query: 597 ---------EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
TPLH A + EVAE LLE GA V + + GL PL
Sbjct: 827 NINCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPL 874
Score = 46.6 bits (109), Expect = 2e-04
Identities = 27/80 (33%), Positives = 39/80 (48%), Gaps = 3/80 (3%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ + ++ G LH AC G + L++ G +N D +TPLHEA + +E+
Sbjct: 392 GADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVC 451
Query: 579 RFLLDHGAAVDDPGGQGCEG 598
LL HGA DP C G
Sbjct: 452 SLLLSHGA---DPTLVNCHG 468
Score = 45.8 bits (107), Expect = 3e-04
Identities = 35/109 (32%), Positives = 53/109 (48%), Gaps = 10/109 (9%)
Query: 530 ETLLHRACIEGQLRRVQD---LVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA 586
ET LH A +R Q L+R+G +N ++ TPLH A H +++ L HGA
Sbjct: 523 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGA 582
Query: 587 AVD--DPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLS 633
++ D GQ T LH A GH + LLL G+ ++ + +G +
Sbjct: 583 KMNALDTLGQ-----TALHRAALAGHLQTCRLLLSYGSDPSIISLQGFT 626
Score = 45.1 bits (105), Expect = 5e-04
Identities = 37/112 (33%), Positives = 51/112 (45%), Gaps = 10/112 (8%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
RKG+ N +N T LH A ++ L + G +N D G T LH A GHL+
Sbjct: 546 RKGANVNEKNKDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQ 605
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRT 628
R LL +G+ DP +G T A G+ V ++L E S +RT
Sbjct: 606 TCRLLLSYGS---DPSIISLQGFT----AAQMGNEAVQQILSE---STPIRT 647
Score = 31.2 bits (69), Expect = 7.2
Identities = 21/85 (24%), Positives = 28/85 (32%), Gaps = 30/85 (35%)
Query: 848 PRPRGTGDNRRPSSTSGSDSEESRPRARAKQVRLTCMQSCSAPVNAGPSSLASEPPGSPS 907
P P G+G N PSS+S P+S +S P SP
Sbjct: 118 PNPAGSGSNNSPSSSS------------------------------SPTSSSSSSPSSPG 147
Query: 908 TPRVSEPSGDSSAAGQPLGPAPPPP 932
+ P ++ PLGP P
Sbjct: 148 SSLAESPEAAGVSSTAPLGPGAAGP 172
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 75.1 bits (183), Expect = 4e-13
Identities = 47/139 (33%), Positives = 69/139 (49%), Gaps = 16/139 (11%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G +R + L+ G P+ + G +P+H A HL+ VR LL + A +DD
Sbjct: 307 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 366
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLD 650
+ +TPLH A +CGH VA++LL++GA R G +PL +
Sbjct: 367 ---ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK---------- 413
Query: 651 LETRQKARAMEMLLQAAAS 669
+ R ME+LL+ AS
Sbjct: 414 ---KNHVRVMELLLKTGAS 429
Score = 71.6 bits (174), Expect = 5e-12
Identities = 46/118 (38%), Positives = 63/118 (53%), Gaps = 3/118 (2%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
KG+K N R G T LH AC + +R ++ L++ G ++ G TPLH A GHL I
Sbjct: 393 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 452
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
V+ LL GA+ P + TPLH A GH EVA+ LL+ A V + + +PL
Sbjct: 453 VKNLLQRGAS---PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 507
Score = 71.2 bits (173), Expect = 6e-12
Identities = 50/150 (33%), Positives = 73/150 (48%), Gaps = 10/150 (6%)
Query: 491 SEGEDDTDGLTPQLEEDEELQGH-----LGRRKGSKWNRRNDMGETLLHRACIEGQLRRV 545
S + G+TP +E GH L K + N N G T LH EG +
Sbjct: 660 SANAESVQGVTPLHLAAQE--GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717
Query: 546 QDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDA 605
L++ G ++ G+TPLH A +YG++++V+FLL H A D + G +PLH A
Sbjct: 718 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA---DVNAKTKLGYSPLHQA 774
Query: 606 LNCGHFEVAELLLERGASVTLRTRKGLSPL 635
GH ++ LLL+ GAS + G +PL
Sbjct: 775 AQQGHTDIVTLLLKNGASPNEVSSDGTTPL 804
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/112 (37%), Positives = 61/112 (54%), Gaps = 3/112 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH A L Q L+ +G +N G TPLH A G++ +VR LLD GA +
Sbjct: 239 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 298
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQ 640
+ + + +TPLH A GH ++E+LL+ GA + +T+ GLSP+ Q
Sbjct: 299 ET---KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 347
Score = 66.6 bits (161), Expect = 2e-10
Identities = 53/159 (33%), Positives = 73/159 (45%), Gaps = 10/159 (6%)
Query: 499 GLTPQLEEDEELQGHLG-----RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
GLTP GHL ++G+ N N ET LH A G + L++
Sbjct: 437 GLTPL--HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 494
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEV 613
+N + TPLH A GH +V+ LL++ A +P G TPLH A GH E
Sbjct: 495 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA---NPNLATTAGHTPLHIAAREGHVET 551
Query: 614 AELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLE 652
LLE+ AS T+KG +PL ++ K+ +L LE
Sbjct: 552 VLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 590
Score = 64.3 bits (155), Expect = 8e-10
Identities = 41/119 (34%), Positives = 62/119 (52%), Gaps = 3/119 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
+ G+ + + G T LH A G L V++L+++G N + TPLH A GH E
Sbjct: 425 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 484
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+ ++LL + A V+ + + TPLH A GH + +LLLE A+ L T G +PL
Sbjct: 485 VAKYLLQNKAKVN---AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 540
Score = 63.9 bits (154), Expect = 1e-09
Identities = 45/124 (36%), Positives = 61/124 (49%), Gaps = 3/124 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R G N N G LH A EG ++ V +L+ + L G T LH A G E
Sbjct: 66 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 125
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+VR L+++GA V+ Q +G TPL+ A H EV + LLE GA+ + T G +PL
Sbjct: 126 VVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 182
Query: 637 TLQQ 640
Q
Sbjct: 183 VALQ 186
Score = 63.9 bits (154), Expect = 1e-09
Identities = 72/254 (28%), Positives = 102/254 (40%), Gaps = 42/254 (16%)
Query: 421 AQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRE--LSVAEDEDE--------EEE 470
A+ Q P + H + V+L L+ P T L +A E E+E
Sbjct: 500 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 559
Query: 471 AEEAAATAES-----EALEAGEVELSEGEDDTD---------GLTP--------QLEEDE 508
A +A T + A + G+V ++E + D GLTP L+ +
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 619
Query: 509 ELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHE 568
L G WN G T LH A + Q+ + L++ G N G TPLH
Sbjct: 620 LLLPRGGSPHSPAWN-----GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 674
Query: 569 ACNYGHLEIVRFLLDHGAAVDDPGGQGCE-GITPLHDALNCGHFEVAELLLERGASVTLR 627
A GH E+V LL A G G + G+TPLH GH VA++L++ G V
Sbjct: 675 AAQEGHAEMVALLLSKQAN----GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 730
Query: 628 TRKGLSPLETLQQW 641
TR G +PL +
Sbjct: 731 TRMGYTPLHVASHY 744
Score = 62.4 bits (150), Expect = 3e-09
Identities = 40/105 (38%), Positives = 55/105 (52%), Gaps = 3/105 (2%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G R + L+ +G N R G+TPLH AC H+ ++ LL GA++D
Sbjct: 373 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID- 431
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
G+TPLH A GH + + LL+RGAS + K +PL
Sbjct: 432 --AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 474
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/122 (33%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G N + G T LH A EG V L+ + N + G TPLH GH+ +
Sbjct: 658 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 717
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L+ HG VD G TPLH A + G+ ++ + LL+ A V +T+ G SPL
Sbjct: 718 DVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 774
Query: 639 QQ 640
Q
Sbjct: 775 AQ 776
Score = 62.0 bits (149), Expect = 4e-09
Identities = 40/103 (38%), Positives = 54/103 (52%), Gaps = 11/103 (10%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA-- 586
G T LH A + GQ V++LV G +N + G+TPL+ A HLE+V+FLL++GA
Sbjct: 111 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 170
Query: 587 --AVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLR 627
A +D G TPL AL GH V L+ G +R
Sbjct: 171 NVATED-------GFTPLAVALQQGHENVVAHLINYGTKGKVR 206
Score = 61.6 bits (148), Expect = 5e-09
Identities = 48/135 (35%), Positives = 63/135 (46%), Gaps = 14/135 (10%)
Query: 520 SKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVR 579
+K N + +T LH A G V+ L+ N G TPLH A GH+E V
Sbjct: 494 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 553
Query: 580 FLLDHGAAVDDPGGQGC---EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
LL+ A+ Q C +G TPLH A G VAELLLER A + GL+PL
Sbjct: 554 ALLEKEAS------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 607
Query: 637 TLQQWVKLYRRDLDL 651
V ++ +LD+
Sbjct: 608 -----VAVHHNNLDI 617
Score = 57.0 bits (136), Expect = 1e-07
Identities = 45/143 (31%), Positives = 63/143 (44%), Gaps = 26/143 (18%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ N ++ G T L+ A E L V+ L+ G N G+TPL A GH +V
Sbjct: 134 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 193
Query: 579 RFLLDHG---------------------AAV-----DDPGGQGCEGITPLHDALNCGHFE 612
L+++G AAV +P G TPLH A + +
Sbjct: 194 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 253
Query: 613 VAELLLERGASVTLRTRKGLSPL 635
VA+LLL RGASV + G++PL
Sbjct: 254 VAQLLLNRGASVNFTPQNGITPL 276
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 75.1 bits (183), Expect = 4e-13
Identities = 47/139 (33%), Positives = 69/139 (49%), Gaps = 16/139 (11%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G +R + L+ G P+ + G +P+H A HL+ VR LL + A +DD
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLD 650
+ +TPLH A +CGH VA++LL++GA R G +PL +
Sbjct: 334 ---ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK---------- 380
Query: 651 LETRQKARAMEMLLQAAAS 669
+ R ME+LL+ AS
Sbjct: 381 ---KNHVRVMELLLKTGAS 396
Score = 71.6 bits (174), Expect = 5e-12
Identities = 46/118 (38%), Positives = 63/118 (53%), Gaps = 3/118 (2%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
KG+K N R G T LH AC + +R ++ L++ G ++ G TPLH A GHL I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
V+ LL GA+ P + TPLH A GH EVA+ LL+ A V + + +PL
Sbjct: 420 VKNLLQRGAS---PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Score = 71.2 bits (173), Expect = 6e-12
Identities = 50/150 (33%), Positives = 73/150 (48%), Gaps = 10/150 (6%)
Query: 491 SEGEDDTDGLTPQLEEDEELQGH-----LGRRKGSKWNRRNDMGETLLHRACIEGQLRRV 545
S + G+TP +E GH L K + N N G T LH EG +
Sbjct: 627 SANAESVQGVTPLHLAAQE--GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 546 QDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDA 605
L++ G ++ G+TPLH A +YG++++V+FLL H A D + G +PLH A
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA---DVNAKTKLGYSPLHQA 741
Query: 606 LNCGHFEVAELLLERGASVTLRTRKGLSPL 635
GH ++ LLL+ GAS + G +PL
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/112 (37%), Positives = 61/112 (54%), Gaps = 3/112 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH A L Q L+ +G +N G TPLH A G++ +VR LLD GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQ 640
+ + + +TPLH A GH ++E+LL+ GA + +T+ GLSP+ Q
Sbjct: 266 ET---KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Score = 66.6 bits (161), Expect = 2e-10
Identities = 53/159 (33%), Positives = 73/159 (45%), Gaps = 10/159 (6%)
Query: 499 GLTPQLEEDEELQGHLG-----RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
GLTP GHL ++G+ N N ET LH A G + L++
Sbjct: 404 GLTPL--HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEV 613
+N + TPLH A GH +V+ LL++ A +P G TPLH A GH E
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA---NPNLATTAGHTPLHIAAREGHVET 518
Query: 614 AELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLE 652
LLE+ AS T+KG +PL ++ K+ +L LE
Sbjct: 519 VLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Score = 64.3 bits (155), Expect = 8e-10
Identities = 41/119 (34%), Positives = 62/119 (52%), Gaps = 3/119 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
+ G+ + + G T LH A G L V++L+++G N + TPLH A GH E
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+ ++LL + A V+ + + TPLH A GH + +LLLE A+ L T G +PL
Sbjct: 452 VAKYLLQNKAKVN---AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Score = 63.9 bits (154), Expect = 1e-09
Identities = 45/124 (36%), Positives = 61/124 (49%), Gaps = 3/124 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R G N N G LH A EG ++ V +L+ + L G T LH A G E
Sbjct: 33 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 92
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+VR L+++GA V+ Q +G TPL+ A H EV + LLE GA+ + T G +PL
Sbjct: 93 VVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 637 TLQQ 640
Q
Sbjct: 150 VALQ 153
Score = 63.9 bits (154), Expect = 1e-09
Identities = 72/254 (28%), Positives = 102/254 (40%), Gaps = 42/254 (16%)
Query: 421 AQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRE--LSVAEDEDE--------EEE 470
A+ Q P + H + V+L L+ P T L +A E E+E
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 471 AEEAAATAES-----EALEAGEVELSEGEDDTD---------GLTP--------QLEEDE 508
A +A T + A + G+V ++E + D GLTP L+ +
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 509 ELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHE 568
L G WN G T LH A + Q+ + L++ G N G TPLH
Sbjct: 587 LLLPRGGSPHSPAWN-----GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Query: 569 ACNYGHLEIVRFLLDHGAAVDDPGGQGCE-GITPLHDALNCGHFEVAELLLERGASVTLR 627
A GH E+V LL A G G + G+TPLH GH VA++L++ G V
Sbjct: 642 AAQEGHAEMVALLLSKQAN----GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 628 TRKGLSPLETLQQW 641
TR G +PL +
Sbjct: 698 TRMGYTPLHVASHY 711
Score = 62.4 bits (150), Expect = 3e-09
Identities = 40/105 (38%), Positives = 55/105 (52%), Gaps = 3/105 (2%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G R + L+ +G N R G+TPLH AC H+ ++ LL GA++D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID- 398
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
G+TPLH A GH + + LL+RGAS + K +PL
Sbjct: 399 --AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/122 (33%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G N + G T LH A EG V L+ + N + G TPLH GH+ +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L+ HG VD G TPLH A + G+ ++ + LL+ A V +T+ G SPL
Sbjct: 685 DVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 639 QQ 640
Q
Sbjct: 742 AQ 743
Score = 62.0 bits (149), Expect = 4e-09
Identities = 40/103 (38%), Positives = 54/103 (52%), Gaps = 11/103 (10%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA-- 586
G T LH A + GQ V++LV G +N + G+TPL+ A HLE+V+FLL++GA
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 587 --AVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLR 627
A +D G TPL AL GH V L+ G +R
Sbjct: 138 NVATED-------GFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 61.6 bits (148), Expect = 5e-09
Identities = 48/135 (35%), Positives = 63/135 (46%), Gaps = 14/135 (10%)
Query: 520 SKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVR 579
+K N + +T LH A G V+ L+ N G TPLH A GH+E V
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 520
Query: 580 FLLDHGAAVDDPGGQGC---EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
LL+ A+ Q C +G TPLH A G VAELLLER A + GL+PL
Sbjct: 521 ALLEKEAS------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 637 TLQQWVKLYRRDLDL 651
V ++ +LD+
Sbjct: 575 -----VAVHHNNLDI 584
Score = 57.0 bits (136), Expect = 1e-07
Identities = 45/143 (31%), Positives = 63/143 (44%), Gaps = 26/143 (18%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ N ++ G T L+ A E L V+ L+ G N G+TPL A GH +V
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 579 RFLLDHG---------------------AAV-----DDPGGQGCEGITPLHDALNCGHFE 612
L+++G AAV +P G TPLH A + +
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 613 VAELLLERGASVTLRTRKGLSPL 635
VA+LLL RGASV + G++PL
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPL 243
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 75.1 bits (183), Expect = 4e-13
Identities = 47/139 (33%), Positives = 69/139 (49%), Gaps = 16/139 (11%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G +R + L+ G P+ + G +P+H A HL+ VR LL + A +DD
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLD 650
+ +TPLH A +CGH VA++LL++GA R G +PL +
Sbjct: 334 ---ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK---------- 380
Query: 651 LETRQKARAMEMLLQAAAS 669
+ R ME+LL+ AS
Sbjct: 381 ---KNHVRVMELLLKTGAS 396
Score = 71.6 bits (174), Expect = 5e-12
Identities = 46/118 (38%), Positives = 63/118 (53%), Gaps = 3/118 (2%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
KG+K N R G T LH AC + +R ++ L++ G ++ G TPLH A GHL I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
V+ LL GA+ P + TPLH A GH EVA+ LL+ A V + + +PL
Sbjct: 420 VKNLLQRGAS---PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Score = 71.2 bits (173), Expect = 6e-12
Identities = 50/150 (33%), Positives = 73/150 (48%), Gaps = 10/150 (6%)
Query: 491 SEGEDDTDGLTPQLEEDEELQGH-----LGRRKGSKWNRRNDMGETLLHRACIEGQLRRV 545
S + G+TP +E GH L K + N N G T LH EG +
Sbjct: 627 SANAESVQGVTPLHLAAQE--GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 546 QDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDA 605
L++ G ++ G+TPLH A +YG++++V+FLL H A D + G +PLH A
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA---DVNAKTKLGYSPLHQA 741
Query: 606 LNCGHFEVAELLLERGASVTLRTRKGLSPL 635
GH ++ LLL+ GAS + G +PL
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/112 (37%), Positives = 61/112 (54%), Gaps = 3/112 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH A L Q L+ +G +N G TPLH A G++ +VR LLD GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQ 640
+ + + +TPLH A GH ++E+LL+ GA + +T+ GLSP+ Q
Sbjct: 266 ET---KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Score = 66.6 bits (161), Expect = 2e-10
Identities = 53/159 (33%), Positives = 73/159 (45%), Gaps = 10/159 (6%)
Query: 499 GLTPQLEEDEELQGHLG-----RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
GLTP GHL ++G+ N N ET LH A G + L++
Sbjct: 404 GLTPL--HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEV 613
+N + TPLH A GH +V+ LL++ A +P G TPLH A GH E
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA---NPNLATTAGHTPLHIAAREGHVET 518
Query: 614 AELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLE 652
LLE+ AS T+KG +PL ++ K+ +L LE
Sbjct: 519 VLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Score = 64.3 bits (155), Expect = 8e-10
Identities = 41/119 (34%), Positives = 62/119 (52%), Gaps = 3/119 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
+ G+ + + G T LH A G L V++L+++G N + TPLH A GH E
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+ ++LL + A V+ + + TPLH A GH + +LLLE A+ L T G +PL
Sbjct: 452 VAKYLLQNKAKVN---AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Score = 63.9 bits (154), Expect = 1e-09
Identities = 45/124 (36%), Positives = 61/124 (49%), Gaps = 3/124 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R G N N G LH A EG ++ V +L+ + L G T LH A G E
Sbjct: 33 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 92
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+VR L+++GA V+ Q +G TPL+ A H EV + LLE GA+ + T G +PL
Sbjct: 93 VVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 637 TLQQ 640
Q
Sbjct: 150 VALQ 153
Score = 63.9 bits (154), Expect = 1e-09
Identities = 72/254 (28%), Positives = 102/254 (40%), Gaps = 42/254 (16%)
Query: 421 AQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRE--LSVAEDEDE--------EEE 470
A+ Q P + H + V+L L+ P T L +A E E+E
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 471 AEEAAATAES-----EALEAGEVELSEGEDDTD---------GLTP--------QLEEDE 508
A +A T + A + G+V ++E + D GLTP L+ +
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 509 ELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHE 568
L G WN G T LH A + Q+ + L++ G N G TPLH
Sbjct: 587 LLLPRGGSPHSPAWN-----GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Query: 569 ACNYGHLEIVRFLLDHGAAVDDPGGQGCE-GITPLHDALNCGHFEVAELLLERGASVTLR 627
A GH E+V LL A G G + G+TPLH GH VA++L++ G V
Sbjct: 642 AAQEGHAEMVALLLSKQAN----GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 628 TRKGLSPLETLQQW 641
TR G +PL +
Sbjct: 698 TRMGYTPLHVASHY 711
Score = 62.4 bits (150), Expect = 3e-09
Identities = 40/105 (38%), Positives = 55/105 (52%), Gaps = 3/105 (2%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G R + L+ +G N R G+TPLH AC H+ ++ LL GA++D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID- 398
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
G+TPLH A GH + + LL+RGAS + K +PL
Sbjct: 399 --AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/122 (33%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G N + G T LH A EG V L+ + N + G TPLH GH+ +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L+ HG VD G TPLH A + G+ ++ + LL+ A V +T+ G SPL
Sbjct: 685 DVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 639 QQ 640
Q
Sbjct: 742 AQ 743
Score = 62.0 bits (149), Expect = 4e-09
Identities = 40/103 (38%), Positives = 54/103 (52%), Gaps = 11/103 (10%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA-- 586
G T LH A + GQ V++LV G +N + G+TPL+ A HLE+V+FLL++GA
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 587 --AVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLR 627
A +D G TPL AL GH V L+ G +R
Sbjct: 138 NVATED-------GFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 61.6 bits (148), Expect = 5e-09
Identities = 48/135 (35%), Positives = 63/135 (46%), Gaps = 14/135 (10%)
Query: 520 SKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVR 579
+K N + +T LH A G V+ L+ N G TPLH A GH+E V
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 520
Query: 580 FLLDHGAAVDDPGGQGC---EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
LL+ A+ Q C +G TPLH A G VAELLLER A + GL+PL
Sbjct: 521 ALLEKEAS------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 637 TLQQWVKLYRRDLDL 651
V ++ +LD+
Sbjct: 575 -----VAVHHNNLDI 584
Score = 57.0 bits (136), Expect = 1e-07
Identities = 45/143 (31%), Positives = 63/143 (44%), Gaps = 26/143 (18%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ N ++ G T L+ A E L V+ L+ G N G+TPL A GH +V
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 579 RFLLDHG---------------------AAV-----DDPGGQGCEGITPLHDALNCGHFE 612
L+++G AAV +P G TPLH A + +
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 613 VAELLLERGASVTLRTRKGLSPL 635
VA+LLL RGASV + G++PL
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPL 243
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 75.1 bits (183), Expect = 4e-13
Identities = 47/139 (33%), Positives = 69/139 (49%), Gaps = 16/139 (11%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G +R + L+ G P+ + G +P+H A HL+ VR LL + A +DD
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLD 650
+ +TPLH A +CGH VA++LL++GA R G +PL +
Sbjct: 334 ---ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK---------- 380
Query: 651 LETRQKARAMEMLLQAAAS 669
+ R ME+LL+ AS
Sbjct: 381 ---KNHVRVMELLLKTGAS 396
Score = 71.6 bits (174), Expect = 5e-12
Identities = 46/118 (38%), Positives = 63/118 (53%), Gaps = 3/118 (2%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
KG+K N R G T LH AC + +R ++ L++ G ++ G TPLH A GHL I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
V+ LL GA+ P + TPLH A GH EVA+ LL+ A V + + +PL
Sbjct: 420 VKNLLQRGAS---PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Score = 71.2 bits (173), Expect = 6e-12
Identities = 50/150 (33%), Positives = 73/150 (48%), Gaps = 10/150 (6%)
Query: 491 SEGEDDTDGLTPQLEEDEELQGH-----LGRRKGSKWNRRNDMGETLLHRACIEGQLRRV 545
S + G+TP +E GH L K + N N G T LH EG +
Sbjct: 627 SANAESVQGVTPLHLAAQE--GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 546 QDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDA 605
L++ G ++ G+TPLH A +YG++++V+FLL H A D + G +PLH A
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA---DVNAKTKLGYSPLHQA 741
Query: 606 LNCGHFEVAELLLERGASVTLRTRKGLSPL 635
GH ++ LLL+ GAS + G +PL
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/112 (37%), Positives = 61/112 (54%), Gaps = 3/112 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH A L Q L+ +G +N G TPLH A G++ +VR LLD GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQ 640
+ + + +TPLH A GH ++E+LL+ GA + +T+ GLSP+ Q
Sbjct: 266 ET---KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Score = 66.6 bits (161), Expect = 2e-10
Identities = 53/159 (33%), Positives = 73/159 (45%), Gaps = 10/159 (6%)
Query: 499 GLTPQLEEDEELQGHLG-----RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
GLTP GHL ++G+ N N ET LH A G + L++
Sbjct: 404 GLTPL--HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEV 613
+N + TPLH A GH +V+ LL++ A +P G TPLH A GH E
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA---NPNLATTAGHTPLHIAAREGHVET 518
Query: 614 AELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLE 652
LLE+ AS T+KG +PL ++ K+ +L LE
Sbjct: 519 VLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Score = 64.3 bits (155), Expect = 8e-10
Identities = 41/119 (34%), Positives = 62/119 (52%), Gaps = 3/119 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
+ G+ + + G T LH A G L V++L+++G N + TPLH A GH E
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+ ++LL + A V+ + + TPLH A GH + +LLLE A+ L T G +PL
Sbjct: 452 VAKYLLQNKAKVN---AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Score = 63.9 bits (154), Expect = 1e-09
Identities = 45/124 (36%), Positives = 61/124 (49%), Gaps = 3/124 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R G N N G LH A EG ++ V +L+ + L G T LH A G E
Sbjct: 33 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 92
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+VR L+++GA V+ Q +G TPL+ A H EV + LLE GA+ + T G +PL
Sbjct: 93 VVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 637 TLQQ 640
Q
Sbjct: 150 VALQ 153
Score = 63.9 bits (154), Expect = 1e-09
Identities = 72/254 (28%), Positives = 102/254 (40%), Gaps = 42/254 (16%)
Query: 421 AQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRE--LSVAEDEDE--------EEE 470
A+ Q P + H + V+L L+ P T L +A E E+E
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 471 AEEAAATAES-----EALEAGEVELSEGEDDTD---------GLTP--------QLEEDE 508
A +A T + A + G+V ++E + D GLTP L+ +
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 509 ELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHE 568
L G WN G T LH A + Q+ + L++ G N G TPLH
Sbjct: 587 LLLPRGGSPHSPAWN-----GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Query: 569 ACNYGHLEIVRFLLDHGAAVDDPGGQGCE-GITPLHDALNCGHFEVAELLLERGASVTLR 627
A GH E+V LL A G G + G+TPLH GH VA++L++ G V
Sbjct: 642 AAQEGHAEMVALLLSKQAN----GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 628 TRKGLSPLETLQQW 641
TR G +PL +
Sbjct: 698 TRMGYTPLHVASHY 711
Score = 62.4 bits (150), Expect = 3e-09
Identities = 40/105 (38%), Positives = 55/105 (52%), Gaps = 3/105 (2%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G R + L+ +G N R G+TPLH AC H+ ++ LL GA++D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID- 398
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
G+TPLH A GH + + LL+RGAS + K +PL
Sbjct: 399 --AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/122 (33%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G N + G T LH A EG V L+ + N + G TPLH GH+ +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L+ HG VD G TPLH A + G+ ++ + LL+ A V +T+ G SPL
Sbjct: 685 DVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 639 QQ 640
Q
Sbjct: 742 AQ 743
Score = 62.0 bits (149), Expect = 4e-09
Identities = 40/103 (38%), Positives = 54/103 (52%), Gaps = 11/103 (10%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA-- 586
G T LH A + GQ V++LV G +N + G+TPL+ A HLE+V+FLL++GA
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 587 --AVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLR 627
A +D G TPL AL GH V L+ G +R
Sbjct: 138 NVATED-------GFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 61.6 bits (148), Expect = 5e-09
Identities = 48/135 (35%), Positives = 63/135 (46%), Gaps = 14/135 (10%)
Query: 520 SKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVR 579
+K N + +T LH A G V+ L+ N G TPLH A GH+E V
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 520
Query: 580 FLLDHGAAVDDPGGQGC---EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
LL+ A+ Q C +G TPLH A G VAELLLER A + GL+PL
Sbjct: 521 ALLEKEAS------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 637 TLQQWVKLYRRDLDL 651
V ++ +LD+
Sbjct: 575 -----VAVHHNNLDI 584
Score = 57.0 bits (136), Expect = 1e-07
Identities = 45/143 (31%), Positives = 63/143 (44%), Gaps = 26/143 (18%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ N ++ G T L+ A E L V+ L+ G N G+TPL A GH +V
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 579 RFLLDHG---------------------AAV-----DDPGGQGCEGITPLHDALNCGHFE 612
L+++G AAV +P G TPLH A + +
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 613 VAELLLERGASVTLRTRKGLSPL 635
VA+LLL RGASV + G++PL
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPL 243
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 75.1 bits (183), Expect = 4e-13
Identities = 47/139 (33%), Positives = 69/139 (49%), Gaps = 16/139 (11%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G +R + L+ G P+ + G +P+H A HL+ VR LL + A +DD
Sbjct: 274 TPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDD 333
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLD 650
+ +TPLH A +CGH VA++LL++GA R G +PL +
Sbjct: 334 ---ITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACK---------- 380
Query: 651 LETRQKARAMEMLLQAAAS 669
+ R ME+LL+ AS
Sbjct: 381 ---KNHVRVMELLLKTGAS 396
Score = 71.6 bits (174), Expect = 5e-12
Identities = 46/118 (38%), Positives = 63/118 (53%), Gaps = 3/118 (2%)
Query: 518 KGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEI 577
KG+K N R G T LH AC + +R ++ L++ G ++ G TPLH A GHL I
Sbjct: 360 KGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPI 419
Query: 578 VRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
V+ LL GA+ P + TPLH A GH EVA+ LL+ A V + + +PL
Sbjct: 420 VKNLLQRGAS---PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPL 474
Score = 71.2 bits (173), Expect = 6e-12
Identities = 50/150 (33%), Positives = 73/150 (48%), Gaps = 10/150 (6%)
Query: 491 SEGEDDTDGLTPQLEEDEELQGH-----LGRRKGSKWNRRNDMGETLLHRACIEGQLRRV 545
S + G+TP +E GH L K + N N G T LH EG +
Sbjct: 627 SANAESVQGVTPLHLAAQE--GHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 546 QDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDA 605
L++ G ++ G+TPLH A +YG++++V+FLL H A D + G +PLH A
Sbjct: 685 DVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQA---DVNAKTKLGYSPLHQA 741
Query: 606 LNCGHFEVAELLLERGASVTLRTRKGLSPL 635
GH ++ LLL+ GAS + G +PL
Sbjct: 742 AQQGHTDIVTLLLKNGASPNEVSSDGTTPL 771
Score = 69.7 bits (169), Expect = 2e-11
Identities = 42/112 (37%), Positives = 61/112 (54%), Gaps = 3/112 (2%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAV 588
G T LH A L Q L+ +G +N G TPLH A G++ +VR LLD GA +
Sbjct: 206 GFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQI 265
Query: 589 DDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQ 640
+ + + +TPLH A GH ++E+LL+ GA + +T+ GLSP+ Q
Sbjct: 266 ET---KTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQ 314
Score = 66.6 bits (161), Expect = 2e-10
Identities = 53/159 (33%), Positives = 73/159 (45%), Gaps = 10/159 (6%)
Query: 499 GLTPQLEEDEELQGHLG-----RRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGH 553
GLTP GHL ++G+ N N ET LH A G + L++
Sbjct: 404 GLTPL--HVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKA 461
Query: 554 PLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEV 613
+N + TPLH A GH +V+ LL++ A +P G TPLH A GH E
Sbjct: 462 KVNAKAKDDQTPLHCAARIGHTNMVKLLLENNA---NPNLATTAGHTPLHIAAREGHVET 518
Query: 614 AELLLERGASVTLRTRKGLSPLETLQQWVKLYRRDLDLE 652
LLE+ AS T+KG +PL ++ K+ +L LE
Sbjct: 519 VLALLEKEASQACMTKKGFTPLHVAAKYGKVRVAELLLE 557
Score = 64.3 bits (155), Expect = 8e-10
Identities = 41/119 (34%), Positives = 62/119 (52%), Gaps = 3/119 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
+ G+ + + G T LH A G L V++L+++G N + TPLH A GH E
Sbjct: 392 KTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTE 451
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+ ++LL + A V+ + + TPLH A GH + +LLLE A+ L T G +PL
Sbjct: 452 VAKYLLQNKAKVN---AKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPL 507
Score = 63.9 bits (154), Expect = 1e-09
Identities = 45/124 (36%), Positives = 61/124 (49%), Gaps = 3/124 (2%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R G N N G LH A EG ++ V +L+ + L G T LH A G E
Sbjct: 33 RNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDE 92
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+VR L+++GA V+ Q +G TPL+ A H EV + LLE GA+ + T G +PL
Sbjct: 93 VVRELVNYGANVN---AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLA 149
Query: 637 TLQQ 640
Q
Sbjct: 150 VALQ 153
Score = 63.9 bits (154), Expect = 1e-09
Identities = 72/254 (28%), Positives = 102/254 (40%), Gaps = 42/254 (16%)
Query: 421 AQQAQRPQLQRQVLQHLHTVQLRLQPQEAPETETRLRE--LSVAEDEDE--------EEE 470
A+ Q P + H + V+L L+ P T L +A E E+E
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 471 AEEAAATAES-----EALEAGEVELSEGEDDTD---------GLTP--------QLEEDE 508
A +A T + A + G+V ++E + D GLTP L+ +
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVK 586
Query: 509 ELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHE 568
L G WN G T LH A + Q+ + L++ G N G TPLH
Sbjct: 587 LLLPRGGSPHSPAWN-----GYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHL 641
Query: 569 ACNYGHLEIVRFLLDHGAAVDDPGGQGCE-GITPLHDALNCGHFEVAELLLERGASVTLR 627
A GH E+V LL A G G + G+TPLH GH VA++L++ G V
Sbjct: 642 AAQEGHAEMVALLLSKQAN----GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 628 TRKGLSPLETLQQW 641
TR G +PL +
Sbjct: 698 TRMGYTPLHVASHY 711
Score = 62.4 bits (150), Expect = 3e-09
Identities = 40/105 (38%), Positives = 55/105 (52%), Gaps = 3/105 (2%)
Query: 531 TLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGAAVDD 590
T LH A G R + L+ +G N R G+TPLH AC H+ ++ LL GA++D
Sbjct: 340 TPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASID- 398
Query: 591 PGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
G+TPLH A GH + + LL+RGAS + K +PL
Sbjct: 399 --AVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPL 441
Score = 62.4 bits (150), Expect = 3e-09
Identities = 41/122 (33%), Positives = 56/122 (45%), Gaps = 3/122 (2%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G N + G T LH A EG V L+ + N + G TPLH GH+ +
Sbjct: 625 GGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVA 684
Query: 579 RFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETL 638
L+ HG VD G TPLH A + G+ ++ + LL+ A V +T+ G SPL
Sbjct: 685 DVLIKHGVMVDATTRM---GYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQA 741
Query: 639 QQ 640
Q
Sbjct: 742 AQ 743
Score = 62.0 bits (149), Expect = 4e-09
Identities = 40/103 (38%), Positives = 54/103 (52%), Gaps = 11/103 (10%)
Query: 529 GETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLDHGA-- 586
G T LH A + GQ V++LV G +N + G+TPL+ A HLE+V+FLL++GA
Sbjct: 78 GNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQ 137
Query: 587 --AVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLR 627
A +D G TPL AL GH V L+ G +R
Sbjct: 138 NVATED-------GFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Score = 61.6 bits (148), Expect = 5e-09
Identities = 48/135 (35%), Positives = 63/135 (46%), Gaps = 14/135 (10%)
Query: 520 SKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVR 579
+K N + +T LH A G V+ L+ N G TPLH A GH+E V
Sbjct: 461 AKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVL 520
Query: 580 FLLDHGAAVDDPGGQGC---EGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
LL+ A+ Q C +G TPLH A G VAELLLER A + GL+PL
Sbjct: 521 ALLEKEAS------QACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLH 574
Query: 637 TLQQWVKLYRRDLDL 651
V ++ +LD+
Sbjct: 575 -----VAVHHNNLDI 584
Score = 57.0 bits (136), Expect = 1e-07
Identities = 45/143 (31%), Positives = 63/143 (44%), Gaps = 26/143 (18%)
Query: 519 GSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIV 578
G+ N ++ G T L+ A E L V+ L+ G N G+TPL A GH +V
Sbjct: 101 GANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVV 160
Query: 579 RFLLDHG---------------------AAV-----DDPGGQGCEGITPLHDALNCGHFE 612
L+++G AAV +P G TPLH A + +
Sbjct: 161 AHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLN 220
Query: 613 VAELLLERGASVTLRTRKGLSPL 635
VA+LLL RGASV + G++PL
Sbjct: 221 VAQLLLNRGASVNFTPQNGITPL 243
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 72.8 bits (177), Expect = 2e-12
Identities = 42/100 (42%), Positives = 56/100 (56%), Gaps = 3/100 (3%)
Query: 524 RRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 583
R + T LH AC G V+ L++ G P+N +D GW+PLH A + G EIV+ LL
Sbjct: 35 RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
Query: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGAS 623
GA V+ GC TPLH A + E+A +LLE GA+
Sbjct: 95 KGAQVNAVNQNGC---TPLHYAASKNRHEIAVMLLEGGAN 131
Score = 60.5 bits (145), Expect = 1e-08
Identities = 56/198 (28%), Positives = 93/198 (46%), Gaps = 21/198 (10%)
Query: 455 RLREL--SVAEDEDEEEEAEEAAATAESEALEAGEVELSE---------GEDDTDGLTP- 502
+L EL S+ D+ ++ + TA A AG E+ E + D G +P
Sbjct: 18 KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77
Query: 503 ----QLEEDEELQGHLGRRKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPR 558
DE ++ LG KG++ N N G T LH A + + L+ G + +
Sbjct: 78 HIAASAGRDEIVKALLG--KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
Query: 559 DYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLL 618
D+ T +H A G+L+++ LL + A+ + Q EG TPLH A + E A+LL+
Sbjct: 136 DHYEATAMHRAAAKGNLKMIHILLYYKASTNI---QDTEGNTPLHLACDEERVEEAKLLV 192
Query: 619 ERGASVTLRTRKGLSPLE 636
+GAS+ + ++ +PL+
Sbjct: 193 SQGASIYIENKEEKTPLQ 210
>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
sapiens]
Length = 151
Score = 72.8 bits (177), Expect = 2e-12
Identities = 42/100 (42%), Positives = 56/100 (56%), Gaps = 3/100 (3%)
Query: 524 RRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 583
R + T LH AC G V+ L++ G P+N +D GW+PLH A + G EIV+ LL
Sbjct: 35 RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
Query: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGAS 623
GA V+ GC TPLH A + E+A +LLE GA+
Sbjct: 95 KGAQVNAVNQNGC---TPLHYAASKNRHEIAVMLLEGGAN 131
Score = 56.6 bits (135), Expect = 2e-07
Identities = 36/97 (37%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 540 GQLRRVQDLVRQGHPLNPR-DYCGWTPLHEACNYGHLEIVRFLLDHGAAVDDPGGQGCEG 598
G+L +++ + L R D T LH AC+ GH EIV FLL G V+D G
Sbjct: 17 GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW-- 74
Query: 599 ITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPL 635
+PLH A + G E+ + LL +GA V + G +PL
Sbjct: 75 -SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPL 110
Score = 37.4 bits (85), Expect = 0.10
Identities = 24/67 (35%), Positives = 35/67 (52%)
Query: 523 NRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLL 582
N ++D G + LH A G+ V+ L+ +G +N + G TPLH A + EI LL
Sbjct: 67 NDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126
Query: 583 DHGAAVD 589
+ GA D
Sbjct: 127 EGGANPD 133
>gi|14195601 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform b [Homo sapiens]
Length = 998
Score = 72.8 bits (177), Expect = 2e-12
Identities = 51/157 (32%), Positives = 82/157 (52%), Gaps = 12/157 (7%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R+GS R D G L AC G V+ L+ +G +N + G T LH+AC +L+
Sbjct: 48 RRGSPRVRFED-GAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLD 105
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+V+FL+++ A V+ Q EG TPLH A +CG+ +AE + GASV + +G P +
Sbjct: 106 MVKFLVENRANVNQ---QDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSD 162
Query: 637 TLQQ-------WVKLYRRDLDLETRQKARAMEMLLQA 666
++ ++ ++ +DLE +K +ML A
Sbjct: 163 LAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDA 199
Score = 48.1 bits (113), Expect = 6e-05
Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 524 RRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 583
R+ G T LH A +G ++ L++ G+ LN +DY GWTPLH A ++G E L +
Sbjct: 212 RQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAE 271
Query: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLER 620
A+ D + G TP D + G E ELL ++
Sbjct: 272 ---ALCDMDIRNKLGQTPF-DVADEGLVEHLELLQKK 304
Score = 35.8 bits (81), Expect = 0.29
Identities = 49/209 (23%), Positives = 79/209 (37%), Gaps = 21/209 (10%)
Query: 594 QGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQW-VK-----LYRR 647
Q G T LH A G+ EV LL++ G + ++ G +PL W VK L
Sbjct: 213 QARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEA 272
Query: 648 DLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTR 707
D++ R K + A G H + L + ET L E NS
Sbjct: 273 LCDMDIRNKLG--QTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLI---ESDLNSKI 327
Query: 708 LPEASQAHVRVSPGQAAP-AMARPRRSRHGPASSSSSSEGEDSAGPA---RPSQKRPRC- 762
+ ++ + P + ++ +SSS EGED A + + + K+P
Sbjct: 328 QSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAF 387
Query: 763 -----SATAQRVAAWTPGPASNREAATAS 786
S + + P PA N +A+++
Sbjct: 388 VNHSNSESKSSITEQIPAPAQNTFSASSA 416
>gi|4505319 protein phosphatase 1, regulatory (inhibitor) subunit
12B isoform a [Homo sapiens]
Length = 982
Score = 72.8 bits (177), Expect = 2e-12
Identities = 51/157 (32%), Positives = 82/157 (52%), Gaps = 12/157 (7%)
Query: 517 RKGSKWNRRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLE 576
R+GS R D G L AC G V+ L+ +G +N + G T LH+AC +L+
Sbjct: 48 RRGSPRVRFED-GAVFL-AACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLD 105
Query: 577 IVRFLLDHGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLE 636
+V+FL+++ A V+ Q EG TPLH A +CG+ +AE + GASV + +G P +
Sbjct: 106 MVKFLVENRANVNQ---QDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSD 162
Query: 637 TLQQ-------WVKLYRRDLDLETRQKARAMEMLLQA 666
++ ++ ++ +DLE +K +ML A
Sbjct: 163 LAEEPAMKDLLLEQVKKQGIDLEQSRKEEEQQMLQDA 199
Score = 48.1 bits (113), Expect = 6e-05
Identities = 34/97 (35%), Positives = 50/97 (51%), Gaps = 4/97 (4%)
Query: 524 RRNDMGETLLHRACIEGQLRRVQDLVRQGHPLNPRDYCGWTPLHEACNYGHLEIVRFLLD 583
R+ G T LH A +G ++ L++ G+ LN +DY GWTPLH A ++G E L +
Sbjct: 212 RQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAE 271
Query: 584 HGAAVDDPGGQGCEGITPLHDALNCGHFEVAELLLER 620
A+ D + G TP D + G E ELL ++
Sbjct: 272 ---ALCDMDIRNKLGQTPF-DVADEGLVEHLELLQKK 304
Score = 35.8 bits (81), Expect = 0.29
Identities = 49/209 (23%), Positives = 79/209 (37%), Gaps = 21/209 (10%)
Query: 594 QGCEGITPLHDALNCGHFEVAELLLERGASVTLRTRKGLSPLETLQQW-VK-----LYRR 647
Q G T LH A G+ EV LL++ G + ++ G +PL W VK L
Sbjct: 213 QARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEA 272
Query: 648 DLDLETRQKARAMEMLLQAAASGQDPHSSQAFHTPSSLLFDPETSPPLSPCPEPPSNSTR 707
D++ R K + A G H + L + ET L E NS
Sbjct: 273 LCDMDIRNKLG--QTPFDVADEGLVEHLELLQKKQNVLRSEKETRNKLI---ESDLNSKI 327
Query: 708 LPEASQAHVRVSPGQAAP-AMARPRRSRHGPASSSSSSEGEDSAGPA---RPSQKRPRC- 762
+ ++ + P + ++ +SSS EGED A + + + K+P
Sbjct: 328 QSGFFKNKEKMLYEEETPKSQEMEEENKESSSSSSEEEEGEDEASESETEKEADKKPEAF 387
Query: 763 -----SATAQRVAAWTPGPASNREAATAS 786
S + + P PA N +A+++
Sbjct: 388 VNHSNSESKSSITEQIPAPAQNTFSASSA 416
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.390
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,445,774
Number of Sequences: 37866
Number of extensions: 3070083
Number of successful extensions: 33168
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 439
Number of HSP's successfully gapped in prelim test: 1295
Number of HSP's that attempted gapping in prelim test: 21944
Number of HSP's gapped (non-prelim): 8917
length of query: 1378
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1263
effective length of database: 13,892,928
effective search space: 17546768064
effective search space used: 17546768064
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.