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Search of human proteins with 187608545
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187608545 centrosomal protein 55kDa [Homo sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187608545 centrosomal protein 55kDa [Homo sapiens] 902 0.0
gi|187608537 centrosomal protein 55kDa [Homo sapiens] 902 0.0
gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens] 89 8e-18
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 74 2e-13
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 73 6e-13
gi|118498356 kinectin 1 isoform a [Homo sapiens] 71 2e-12
gi|118498368 kinectin 1 isoform c [Homo sapiens] 71 2e-12
gi|33620775 kinectin 1 isoform a [Homo sapiens] 71 2e-12
gi|156104908 myosin heavy chain 6 [Homo sapiens] 71 2e-12
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 70 4e-12
gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens] 70 5e-12
gi|55770834 centromere protein F [Homo sapiens] 70 5e-12
gi|118498362 kinectin 1 isoform b [Homo sapiens] 69 7e-12
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 69 7e-12
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 69 7e-12
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 69 7e-12
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 69 7e-12
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 69 7e-12
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 69 7e-12
gi|71061468 centromere protein E [Homo sapiens] 69 7e-12
gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo ... 69 9e-12
gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo... 69 1e-11
gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo... 69 1e-11
gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo s... 68 2e-11
gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo... 68 2e-11
gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [H... 68 2e-11
gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo... 68 2e-11
gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens] 67 3e-11
gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens] 67 3e-11
gi|64085252 hypothetical protein LOC145508 [Homo sapiens] 67 3e-11
>gi|187608545 centrosomal protein 55kDa [Homo sapiens]
Length = 464
Score = 902 bits (2330), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL 60
MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL
Sbjct: 1 MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL 60
Query: 61 EKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKA 120
EKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKA
Sbjct: 61 EKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKA 120
Query: 121 LSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK 180
LSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK
Sbjct: 121 LSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK 180
Query: 181 NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDL 240
NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDL
Sbjct: 181 NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDL 240
Query: 241 LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHK 300
LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHK
Sbjct: 241 LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHK 300
Query: 301 TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACT 360
TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACT
Sbjct: 301 TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACT 360
Query: 361 LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENRE 420
LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENRE
Sbjct: 361 LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENRE 420
Query: 421 KVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK 464
KVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK
Sbjct: 421 KVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK 464
>gi|187608537 centrosomal protein 55kDa [Homo sapiens]
Length = 464
Score = 902 bits (2330), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL 60
MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL
Sbjct: 1 MSSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL 60
Query: 61 EKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKA 120
EKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKA
Sbjct: 61 EKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKA 120
Query: 121 LSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK 180
LSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK
Sbjct: 121 LSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK 180
Query: 181 NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDL 240
NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDL
Sbjct: 181 NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDL 240
Query: 241 LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHK 300
LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHK
Sbjct: 241 LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHK 300
Query: 301 TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACT 360
TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACT
Sbjct: 301 TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACT 360
Query: 361 LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENRE 420
LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENRE
Sbjct: 361 LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENRE 420
Query: 421 KVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK 464
KVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK
Sbjct: 421 KVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVEYCSK 464
>gi|62243484 sarcoma antigen NY-SAR-41 [Homo sapiens]
Length = 1417
Score = 89.0 bits (219), Expect = 8e-18
Identities = 100/476 (21%), Positives = 208/476 (43%), Gaps = 61/476 (12%)
Query: 20 NSKSETTLEKLKGEIAHLKTSVDE------ITSGKGKLTDKERHRLLEK-IRVLEAEKEK 72
N++ E L + +I L+T+++ + K K E+H+ +EK I LEA+ EK
Sbjct: 720 NAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIERLEAQLEK 779
Query: 73 NAYQLTEKDKEIQRLRDQLKARYSTTALLEQL-----EETTREGERREQVLKAL----SE 123
Q E++K + L+ + + L++L E +E ++++ LKAL SE
Sbjct: 780 KDQQFKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKENMKKDEALKALQNQVSE 839
Query: 124 EK----------DVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCF-------NSSINN 166
E ++ K++L +++ + K ++ C N S+
Sbjct: 840 ETIKVRQLDSALEICKEELVLHLNQLEGNKEKFEKQLKKKSEEVYCLQKELKIKNHSLQE 899
Query: 167 IHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIF--------ELEKKTETAAHSLPQ 218
E + L+ L++ QQ L + R ++ K+ EL+K+ E++A L +
Sbjct: 900 TSEQNVILQHTLQQQQQMLQQETIRNGELEDTQTKLEKQVSKLEQELQKQRESSAEKLRK 959
Query: 219 QTKKPESEGYLQEEKQKCYNDLLASAKK---DLEVERQTITQLSFELSEFRRKYEETQKE 275
+K ES + + K++ +L +A++ +++ ++ ++++ E+ +R E
Sbjct: 960 MEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEELSKMEKEIMHLKRDGENKAMH 1019
Query: 276 VHNLNQLL------YSQRRADVQHLEDDRHKTE--------KIQKLREENDIARGKLEEE 321
+ L+ +L ++ V+ LE +H TE K + L E A G+L+
Sbjct: 1020 LSQLDMILDQTKTELEKKTNAVKELEKLQHSTETELTEALQKREVLETELQNAHGELKST 1079
Query: 322 KKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
++ +EL +Q SL +E+ T + L +++ C ++ E++K + + L
Sbjct: 1080 LRQLQELRDVLQKAQLSL---EEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERN 1136
Query: 382 KELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESL 437
EL++ Q+T L+ + H + + ++ +G E E +LN+ L
Sbjct: 1137 WELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKECNKQIESLNDKL 1192
Score = 65.1 bits (157), Expect = 1e-10
Identities = 95/458 (20%), Positives = 194/458 (42%), Gaps = 45/458 (9%)
Query: 3 SRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLT------DKER 56
S+ ++L K + S K E E E + V E+T ++ +E
Sbjct: 940 SKLEQELQKQRESSAEKLRKMEEKCESAAHEADLKRQKVIELTGTARQVKIEMDQYKEEL 999
Query: 57 HRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQ 116
++ ++I L+ + E A L++ D + + + +L+ + + LE+L+ +T E E E
Sbjct: 1000 SKMEKEIMHLKRDGENKAMHLSQLDMILDQTKTELEKKTNAVKELEKLQHST-ETELTEA 1058
Query: 117 VLK--ALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQL 174
+ K L E +L + ++ EL +LS + E ++++
Sbjct: 1059 LQKREVLETELQNAHGELKSTLRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEI 1118
Query: 175 KDALEKNQQWLVYDQ----------QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPE 224
+D K Q+ L DQ QR V L I E + E L +K E
Sbjct: 1119 ED---KKQELLEMDQALKERNWELKQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSE 1175
Query: 225 SEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLY 284
E ++ + ND L +AK+ L + + Q E+S+ +++ E TQ+ + + ++
Sbjct: 1176 LELKECNKQIESLNDKLQNAKEQLREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMK 1235
Query: 285 SQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSL--LKQ 342
Q + ++ ++++ RE+ + +L E + + + +++ L + L +KQ
Sbjct: 1236 EQEQYIATQYKEAIDLGQELRLTREQVQNSHTELAEARHQQVQAQREIERLSSELEDMKQ 1295
Query: 343 --QEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQL 400
+E+ L +++ A K+ H++ ++ +K+L ++ESLK+
Sbjct: 1296 LSKEKDAHGNHLAEELGA-------SKVREAHLEARMQAEIKKLS------AEVESLKEA 1342
Query: 401 HEFAITEPLVTFQGETENREKVAA-SPKSPTAALNESL 437
+ +++ Q E + K++A S KS LNE L
Sbjct: 1343 YHM----EMISHQ-ENHAKWKISADSQKSSVQQLNEQL 1375
Score = 55.8 bits (133), Expect = 8e-08
Identities = 73/316 (23%), Positives = 128/316 (40%), Gaps = 40/316 (12%)
Query: 125 KDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDA------L 178
+D + + I L K N LR +S + + +L + L
Sbjct: 217 RDKMFSSSAPVDQEIKSLREKLNKLRQQNACLVTQNHSLMTKFESIHFELTQSRAKVSML 276
Query: 179 EKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKP-ESEGYLQEEKQKCY 237
E QQ E + L A++ +K A + L Q K E E LQE K++C
Sbjct: 277 ESAQQQAASVPILEEQIINLEAEVSAQDKVLREAENKLEQSQKMVIEKEQSLQESKEECI 336
Query: 238 N---DLLASAKKDLEVERQ------TITQLSFELSEFRRKYEETQKEVHNLNQLLYS--- 285
DLL K+ ERQ +LS ++++K E ++V ++L
Sbjct: 337 KLKVDLLEQTKQGKRAERQRNEALYNAEELSKAFQQYKKKVAEKLEKVQAEEEILERNLT 396
Query: 286 ---------QRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLY 336
Q R + E + K EK+++L+EEN+ + KL ++ E+++Q+
Sbjct: 397 NCEKENKRLQERCGLYKSELEILK-EKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESR 455
Query: 337 TSLLKQQEE--------QTRVALLEQQMQ-ACTLDFENEKLDRQHVQHQLHVILKELRKA 387
S+LK + E + + +L+ + + + +NE+LD Q ++ ELR
Sbjct: 456 QSILKLESELENKDEILRDKFSLMNENRELKVRVAAQNERLDL--CQQEIESSRVELRSL 513
Query: 388 RNQITQLESLKQLHEF 403
I+QL ++L F
Sbjct: 514 EKIISQLPLKRELFGF 529
Score = 51.6 bits (122), Expect = 1e-06
Identities = 80/380 (21%), Positives = 155/380 (40%), Gaps = 70/380 (18%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEK 80
S+ + L++ K E+ +V E+ + T+ E L+K VLE E + +L
Sbjct: 1021 SQLDMILDQTKTELEKKTNAVKELEKLQHS-TETELTEALQKREVLETELQNAHGELKST 1079
Query: 81 DKEIQRLRD-------QLKARYSTTA-LLEQLEETTREGERREQVL----KALSEEKDVL 128
+++Q LRD L+ +Y+T L +L E E E ++Q L +AL E L
Sbjct: 1080 LRQLQELRDVLQKAQLSLEEKYTTIKDLTAELRECKMEIEDKKQELLEMDQALKERNWEL 1139
Query: 129 KQQLSAAT-------SRIAELESKT----NTLRLSQTVAPNCFNSSINNIHEMEIQLKDA 177
KQ+ + T E+E K TL S+ C N I ++++ K+
Sbjct: 1140 KQRAAQVTHLDMTIREHRGEMEQKIIKLEGTLEKSELELKEC-NKQIESLNDKLQNAKEQ 1198
Query: 178 LEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGY--------L 229
L + + ++ ++Q +K + + + K+ E+ Q E
Sbjct: 1199 LREKEFIMLQNEQEISQLKKEIERTQQRMKEMESVMKEQEQYIATQYKEAIDLGQELRLT 1258
Query: 230 QEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQR-- 287
+E+ Q + +L + + ++ +R+ I +LS EL + ++ +E ++L + L + +
Sbjct: 1259 REQVQNSHTELAEARHQQVQAQRE-IERLSSELEDMKQLSKEKDAHGNHLAEELGASKVR 1317
Query: 288 ---------------RADVQHLEDDRH-------------------KTEKIQKLREENDI 313
A+V+ L++ H + +Q+L E+ +
Sbjct: 1318 EAHLEARMQAEIKKLSAEVESLKEAYHMEMISHQENHAKWKISADSQKSSVQQLNEQLEK 1377
Query: 314 ARGKLEEEKKRSEELLSQVQ 333
A+ +LEE + L QVQ
Sbjct: 1378 AKLELEEAQDTVSNLHQQVQ 1397
Score = 49.7 bits (117), Expect = 6e-06
Identities = 88/439 (20%), Positives = 187/439 (42%), Gaps = 53/439 (12%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL------------------EKI 63
+ E +L++ K E LK + E T +GK +++R+ L EK+
Sbjct: 323 EKEQSLQESKEECIKLKVDLLEQTK-QGKRAERQRNEALYNAEELSKAFQQYKKKVAEKL 381
Query: 64 RVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALL-EQLEETTREGERREQVLKALS 122
++AE+E LT +KE +RL+++ S +L E+L + E ++ L+ ++
Sbjct: 382 EKVQAEEEILERNLTNCEKENKRLQERCGLYKSELEILKEKLRQLKEENNNGKEKLRIMA 441
Query: 123 EEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQ 182
+ + QL+ + I +LES+ L + + F S +N E+++++ +N+
Sbjct: 442 VKNSEVMAQLTESRQSILKLESE---LENKDEILRDKF-SLMNENRELKVRV---AAQNE 494
Query: 183 QWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLA 242
+ + Q+ ++ ++ LEK LP + + + YL + + +
Sbjct: 495 RLDLCQQE----IESSRVELRSLEK----IISQLPLKRELFGFKSYLSKYQMSSF----- 541
Query: 243 SAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTE 302
S K+D + +L +SE R K + E+ L+ L + + + +D ++
Sbjct: 542 SNKEDRCIGCCEANKL--VISELRIKLAIKEAEIQKLHANLTANQLSQSLITCNDSQESS 599
Query: 303 KIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLD 362
K+ L E G + +E + Q Q +++ ++ + E + + ++
Sbjct: 600 KLSSLETEPVKLGG-----HQVAESVKDQNQHTMNKQYEKERQRLVTGIEELRTKLIQIE 654
Query: 363 FENE--KLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENRE 420
EN K++ H Q +I +EL + + ++LES L+T + + E +
Sbjct: 655 AENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLES----EMTKKCSQLLTLEKQLEEKI 710
Query: 421 KVAASPKSPTAALNESLVE 439
+S + A L + L+E
Sbjct: 711 VAYSSIAAKNAELEQELME 729
Score = 40.8 bits (94), Expect = 0.003
Identities = 82/423 (19%), Positives = 169/423 (39%), Gaps = 57/423 (13%)
Query: 43 EITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLE 102
EI K + +E + EK+R++ + + QLTE + I +L +L+ + +L
Sbjct: 417 EILKEKLRQLKEENNNGKEKLRIMAVKNSEVMAQLTESRQSILKLESELE---NKDEILR 473
Query: 103 QLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTV------- 155
E + + A +E D+ +Q++ ++ + LE + L L + +
Sbjct: 474 DKFSLMNENRELKVRVAAQNERLDLCQQEIESSRVELRSLEKIISQLPLKRELFGFKSYL 533
Query: 156 --------------APNCFNSSINNIHEMEIQL--KDA-LEKNQQWLVYDQQREVYV--- 195
C ++ I E+ I+L K+A ++K L +Q + +
Sbjct: 534 SKYQMSSFSNKEDRCIGCCEANKLVISELRIKLAIKEAEIQKLHANLTANQLSQSLITCN 593
Query: 196 -KGLLAKIFELEKKT-----ETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
+K+ LE + A S+ Q + ++ Y ++E+Q+ + K ++
Sbjct: 594 DSQESSKLSSLETEPVKLGGHQVAESVKDQNQHTMNKQY-EKERQRLVTGIEELRTKLIQ 652
Query: 250 VERQTI---TQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKI-- 304
+E + ++ S+F+ EE ++ N ++L + Q L ++ EKI
Sbjct: 653 IEAENSDLKVNMAHRTSQFQLIQEELLEKASNSSKLESEMTKKCSQLLTLEKQLEEKIVA 712
Query: 305 -QKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVAL---LEQQMQACT 360
+ +N +L E+ ++ L + + + + E+ ++ L E + Q
Sbjct: 713 YSSIAAKNAELEQELMEKNEKIRSLETNINTEHEKICLAFEKAKKIHLEQHKEMEKQIER 772
Query: 361 LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGE--TEN 418
L+ + EK D+Q KE K + + Q KQ H ++ L +GE EN
Sbjct: 773 LEAQLEKKDQQ---------FKEQEKTMSMLQQDIICKQHHLESLDRLLTESKGEMKKEN 823
Query: 419 REK 421
+K
Sbjct: 824 MKK 826
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 74.3 bits (181), Expect = 2e-13
Identities = 100/441 (22%), Positives = 192/441 (43%), Gaps = 46/441 (10%)
Query: 28 EKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRL 87
+KL+ E + LK D+++S ++ K + L + R LE + +L K++E QRL
Sbjct: 1218 QKLEKEKSELKMETDDLSSNAEAIS-KAKGNLEKMCRSLEDQVS----ELKTKEEEQQRL 1272
Query: 88 RDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTN 147
+ L A+ + L + E +R+ + ++ ++ LS K QQ+ ++ E N
Sbjct: 1273 INDLTAQRAR--LQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKN 1330
Query: 148 TLRLS-QTVAPNC--FNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFE 204
L + Q+ +C E + +L+ AL K + Q R Y + + E
Sbjct: 1331 ALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVA--QWRTKYETDAIQRTEE 1388
Query: 205 LEKKTETAAHSLPQQTKKPESEGY----LQEEKQKCYNDLLASAKKDLEVERQTIT---- 256
LE+ + A L + + E+ L++ KQ+ N++ L+VER
Sbjct: 1389 LEEAKKKLAQRLQEAEEHVEAVNAKCASLEKTKQRLQNEV---EDLMLDVERSNAACAAL 1445
Query: 257 ---QLSFE--LSEFRRKYEET-------QKEVHNLNQLLYSQRRADVQHLEDDRHKTEKI 304
Q +F+ LSE+++KYEET QKE +L+ L+ + + L +++
Sbjct: 1446 DKKQRNFDKVLSEWKQKYEETQAELEASQKESRSLSTELFKVKNVYEESL-------DQL 1498
Query: 305 QKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFE 364
+ LR EN + ++ + ++ E Q+ L +K+Q EQ + ++ ++ E
Sbjct: 1499 ETLRRENKNLQQEISDLTEQIAEGGKQIHEL--EKIKKQVEQEKCE-IQAALEEAEASLE 1555
Query: 365 NEKLDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVA 423
+E+ +Q +L+ + E+ RK + +++ LK+ H + T E +R
Sbjct: 1556 HEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDAL 1615
Query: 424 ASPKSPTAALNESLVECPKCN 444
K LNE ++ N
Sbjct: 1616 RVKKKMEGDLNEMEIQLNHAN 1636
Score = 50.4 bits (119), Expect = 3e-06
Identities = 84/413 (20%), Positives = 163/413 (39%), Gaps = 51/413 (12%)
Query: 27 LEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQR 86
LEK+K ++ K + + E ++L L K + ++ EKD+EI
Sbjct: 1529 LEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEI-- 1586
Query: 87 LRDQLKARYSTTALLEQLEETT----REGERREQVLKALSEEKDVLKQQLSAATSRIAE- 141
DQLK + T ++E ++ T R +V K + + + ++ QL+ A AE
Sbjct: 1587 --DQLKRNH--TRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHANRLAAES 1642
Query: 142 LESKTNT---LRLSQTVAPNCFNSSINNIHEMEIQLKDA----LEKNQQWLVYDQ---QR 191
L + NT L+ +Q + + ++ I + A E + W +Q R
Sbjct: 1643 LRNYRNTQGILKETQLHLDDALRGQEDLKEQLAIVERRANLLQAEIEELWATLEQTERSR 1702
Query: 192 EVYVKGLL-------------AKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYN 238
++ + LL + +KK E L + ++ E EEK K
Sbjct: 1703 KIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRNAEEKAKKAI 1762
Query: 239 DLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDR 298
A ++L+ E+ T S L ++ E+T K++ Q R D +
Sbjct: 1763 TDAAMMAEELKKEQDT----SAHLERMKKNLEQTVKDL---------QHRLDEAEQLALK 1809
Query: 299 HKTEKIQKLREENDIARGKLEEEKKRSEE----LLSQVQFLYTSLLKQQEEQTRVALLEQ 354
++IQKL G++E E+KR+ E L + + + +E++ V L+
Sbjct: 1810 GGKKQIQKLEARVRELEGEVENEQKRNAEAVKGLRKHERRVKELTYQTEEDRKNVLRLQD 1869
Query: 355 QMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITE 407
+ ++ K + + Q + L + RK ++++ + E + E + +
Sbjct: 1870 LVDKLQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIAESQVNK 1922
Score = 48.5 bits (114), Expect = 1e-05
Identities = 71/282 (25%), Positives = 118/282 (41%), Gaps = 26/282 (9%)
Query: 115 EQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQL 174
E+ + + EE K +L+ + ++ ELE K TL + N + L
Sbjct: 849 EKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEK-------NDLQLQVQSEADSL 901
Query: 175 KDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQ 234
DA E+ +Q + Q E +K ++ E ++ E L + +K E E E +
Sbjct: 902 ADAEERCEQLIKNKIQLEAKIK----EVTERAEEEEEINAELTAKKRKLEDEC---SELK 954
Query: 235 KCYNDL---LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADV 291
K +DL LA +K+ + L+ E++ + KE L + + Q D+
Sbjct: 955 KDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQET-HQQTLDDL 1013
Query: 292 QHLEDDRHKTEKIQ-KLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVA 350
Q ED + K + KL ++ D G LE+EKK +L + L L QE +
Sbjct: 1014 QAEEDKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDME 1073
Query: 351 LLEQQM--QACTLDFENEKL-----DRQHVQHQLHVILKELR 385
+QQ+ + +FE L D Q V+ QL +KEL+
Sbjct: 1074 NDKQQLDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQ 1115
Score = 48.1 bits (113), Expect = 2e-05
Identities = 107/502 (21%), Positives = 204/502 (40%), Gaps = 69/502 (13%)
Query: 4 RSTKD-LIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTD--KERHRLL 60
+ TKD L KS+ K K T L++ +++ D + + + K + +L
Sbjct: 860 QKTKDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLE 919
Query: 61 EKIRVL----EAEKEKNAYQLTEKDKEIQRLRDQLKARYS----TTALLEQ--------L 104
KI+ + E E+E NA +LT K ++++ +LK T A +E+ +
Sbjct: 920 AKIKEVTERAEEEEEINA-ELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKV 978
Query: 105 EETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSI 164
+ T E ++ + LS+EK L++ + E K N L ++T +
Sbjct: 979 KNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLE 1038
Query: 165 NNIHEMEIQLKDALEKNQQWLVYD-QQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKP 223
++ E E +L+ LE+ ++ L D + + + +L++K E + K
Sbjct: 1039 GSL-EQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEKLEKKEFEISNLISKI 1097
Query: 224 ESEGYLQEEKQKCYNDLLASAK---KDLEVERQTITQLSFELSEFRRKYEETQKEVHNLN 280
E E ++ + QK +L A + +++E ER + + + S+ R+ EE + +
Sbjct: 1098 EDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQRSDLSRELEEISERLEEAG 1157
Query: 281 QL------LYSQRRADVQHLEDD----------------RHKTEKIQKLREEND-IARGK 317
L +R A+ Q L D + + + +L E+ D + R K
Sbjct: 1158 GATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVK 1217
Query: 318 LEEEKKRSE------ELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKL--- 368
+ EK++SE +L S + + S K E+ +L +Q + T + E ++L
Sbjct: 1218 QKLEKEKSELKMETDDLSSNAEAI--SKAKGNLEKMCRSLEDQVSELKTKEEEQQRLIND 1275
Query: 369 ---DRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAAS 425
R +Q + ++L + ++QL KQ I E + ET+ + +A
Sbjct: 1276 LTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALA-- 1333
Query: 426 PKSPTAALNESLVECPKCNIQY 447
AL S +C QY
Sbjct: 1334 -----HALQSSRHDCDLLREQY 1350
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 72.8 bits (177), Expect = 6e-13
Identities = 93/403 (23%), Positives = 169/403 (41%), Gaps = 65/403 (16%)
Query: 70 KEKNAYQLTEKDKEIQRLRDQL-KARYSTTALLEQLEETTREGERREQVLKALSEEKDVL 128
K K Q+T +++E+Q ++L K + T + +LEE R+ ++ L EEK++L
Sbjct: 840 KVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQ-------LLEEKNIL 892
Query: 129 KQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYD 188
+QL A T AE E L + +H++E ++++ E+NQ
Sbjct: 893 AEQLQAETELFAEAEEMRARLAAKKQELEEI-------LHDLESRVEEEEERNQILQNEK 945
Query: 189 QQREVYVKGLLAKIFELE---KKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAK 245
++ + +++ L ++ E E +K + + + KK E E L E++ N K
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQ----NSKFIKEK 1001
Query: 246 KDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQ 305
K +E I + S +L+E K + K + N +++ S D + +K +
Sbjct: 1002 KLME---DRIAECSSQLAEEEEKAKNLAK-IRNKQEVMIS----------DLEERLKKEE 1047
Query: 306 KLREENDIARGKLEEE----KKRSEELLSQVQFLYTSLLKQQEEQTR------------- 348
K R+E + A+ KL+ E + + EL +Q+ L L K++EE
Sbjct: 1048 KTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKN 1107
Query: 349 -----VALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQL-------ES 396
V L+ Q+ DFE+EK R + Q + +EL + ++ +
Sbjct: 1108 NALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQE 1167
Query: 397 LKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVE 439
L+ E + E + ET+N E + A E L E
Sbjct: 1168 LRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSE 1210
Score = 60.8 bits (146), Expect = 2e-09
Identities = 104/459 (22%), Positives = 188/459 (40%), Gaps = 71/459 (15%)
Query: 2 SSRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLE 61
SS+ ++ K+K +K N K E + L+ + + + E+ K KL D E L +
Sbjct: 1012 SSQLAEEEEKAKNLAKIRN-KQEVMISDLEERLKKEEKTRQELEKAKRKL-DGETTDLQD 1069
Query: 62 KIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKAL 121
+I L+A+ ++ QL +K++E+Q AL +ET + LK +
Sbjct: 1070 QIAELQAQIDELKLQLAKKEEELQG------------ALARGDDETLH----KNNALKVV 1113
Query: 122 SEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKN 181
E + ++IAEL+ + + S+ A + ++ +L+D L+
Sbjct: 1114 RELQ-----------AQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTT 1162
Query: 182 --QQWLVYDQQREV---------YVKGLLAKIFELEKKTETAAHSLPQQTKKPES-EGYL 229
QQ L +++EV K A+I ++ ++ TA L +Q ++ + + L
Sbjct: 1163 AAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANL 1222
Query: 230 QEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRA 289
++ KQ D K+L E + + Q+ E R+K + +E+H
Sbjct: 1223 EKNKQGLETD-----NKELACEVKVLQQVKAESEHKRKKLDAQVQELH------------ 1265
Query: 290 DVQHLEDDRHK---TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQE-- 344
+ E DR + EK KL+ E D LEE +K+ + L + L QE
Sbjct: 1266 -AKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELL 1324
Query: 345 -EQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEF 403
E+TR L + + E EK Q Q + K L K Q+ L+S +
Sbjct: 1325 QEETRQKL---NLSSRIRQLEEEKNSLQEQQEEEEEARKNLEK---QVLALQSQLADTKK 1378
Query: 404 AITEPLVTFQGETENREKVAASPKSPTAALNESLVECPK 442
+ + L T + E ++K+ ++ + L E + K
Sbjct: 1379 KVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDK 1417
Score = 60.8 bits (146), Expect = 2e-09
Identities = 86/375 (22%), Positives = 155/375 (41%), Gaps = 56/375 (14%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K E T +L+ E+ L +D L K++ + ++L EK +A E+D
Sbjct: 1417 KLEKTKNRLQQELDDLTVDLDHQRQVASNLEKKQK----KFDQLLAEEKSISARYAEERD 1472
Query: 82 KEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKA------------------LSE 123
+ R++ S LE+ E E ER+ + L+A L +
Sbjct: 1473 RAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEK 1532
Query: 124 EKDVLKQQLSAATSRIAELESK---TNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK 180
K L+QQ+ +++ ELE + T +L V + E ++Q +D +
Sbjct: 1533 SKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQF----ERDLQTRDEQNE 1588
Query: 181 NQQWLVYDQQREVYV-----KGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQK 235
++ L+ Q RE+ + A +KK E L Q E+ ++E K
Sbjct: 1589 EKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQI---EAANKARDEVIK 1645
Query: 236 CYNDLLASAK---KDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQ 292
L A K ++LE R + ++ + E +K + + E+ L + L S RA
Sbjct: 1646 QLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERA--- 1702
Query: 293 HLEDDRHKTEKIQKLREE-NDIARGK--LEEEKKRSEELLSQVQFLYTSLLKQQEEQTRV 349
RH ++ +L +E + A GK L +EK+R E ++Q++ + +EEQ+ +
Sbjct: 1703 ----RRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLE------EELEEEQSNM 1752
Query: 350 ALLEQQMQACTLDFE 364
LL + + TL +
Sbjct: 1753 ELLNDRFRKTTLQVD 1767
Score = 43.1 bits (100), Expect = 5e-04
Identities = 58/254 (22%), Positives = 110/254 (43%), Gaps = 49/254 (19%)
Query: 182 QQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLL 241
Q W V+ + VK LL + E+ L + K+ + EG L+E ++K + L
Sbjct: 833 QWWRVFTK-----VKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERK--HQQL 885
Query: 242 ASAKKDLEVERQTITQLSFELSEFRR----KYEETQKEVHNL----------NQLLYSQR 287
K L + Q T+L E E R K +E ++ +H+L NQ+L +++
Sbjct: 886 LEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
Query: 288 R---ADVQHLEDDRHKTE---------------KIQKLREE---NDIARGKLEEEKKRSE 326
+ A +Q LE+ + E KI+K+ EE + K +EKK E
Sbjct: 946 KKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005
Query: 327 ELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFE----NEKLDRQHVQHQLHVILK 382
+ +++ + L +++E+ +A + + + D E E+ RQ ++ +
Sbjct: 1006 DRIAECS---SQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDG 1062
Query: 383 ELRKARNQITQLES 396
E ++QI +L++
Sbjct: 1063 ETTDLQDQIAELQA 1076
>gi|118498356 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 71.2 bits (173), Expect = 2e-12
Identities = 106/463 (22%), Positives = 201/463 (43%), Gaps = 71/463 (15%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K + E+++ EIAHLK + T++ + ++ L + + +LTEK
Sbjct: 407 KFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKT 466
Query: 82 KEIQRLRDQLK-ARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLS----AAT 136
++Q+ Q K A + T L QL+E R E + ++ + E + +Q L A
Sbjct: 467 GKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE 526
Query: 137 SRIAELESK-TNTLRLSQTVAPNCF------NSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
+ + L SK T+TL Q + +N +++Q++D LE+N+ Q
Sbjct: 527 NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQ 586
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
Q F + +T+A L ++ K +E ++++ K D LAS
Sbjct: 587 Q------------FHSQIAAQTSASVLAEELHKVIAE---KDKQIKQTEDSLAS------ 625
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRH----KTEKIQ 305
ER +T EL + + + EV L Q L +++ A LE + K +KI+
Sbjct: 626 -ERDRLTSKEEELKDIQNMNFLLKAEVQKL-QALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 306 KLRE--ENDIARGKLEEEK---KRSEELLSQVQFLYTSLLKQ-------------QEEQT 347
L E +++I+ K+EE K +++ L S+VQ L T + +Q QE+
Sbjct: 684 LLEEQLQHEIS-NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDE 742
Query: 348 RVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELR----KARNQI---TQLESLKQ- 399
++ +E+ ++ + ++ + ++ + + KE++ K +Q+ + +E LK+
Sbjct: 743 KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV 802
Query: 400 LHE-----FAITEPLVTFQGETENREKVAASPKSPTAALNESL 437
+HE ++ E L + N+EK K AL E +
Sbjct: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
Score = 62.4 bits (150), Expect = 8e-10
Identities = 104/486 (21%), Positives = 208/486 (42%), Gaps = 83/486 (17%)
Query: 15 GSKPSNSKSETTLEKLKGEIAH----LKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEK 70
G + + + LE+ + ++A+ L+ +E S K + + +H L E + E+
Sbjct: 871 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 930
Query: 71 EKNAYQLTEKDKEIQRLRDQLKARYST----TALLE-----------QLEETTREGERR- 114
+ L EK+ E++RL LK R S T LL+ Q+E+ ++ ++
Sbjct: 931 LEIV--LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 988
Query: 115 ------EQVLKALSE-EKDV--LKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSIN 165
E++LK +SE EK++ L +L + + K N LR A S+
Sbjct: 989 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 166 NIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKI--------------FELEKKTET 211
+ + K + E+ QQ + + + +K L K+ FE + K
Sbjct: 1049 MLQDKVN--KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1106
Query: 212 AAHSLPQQTK--------KPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELS 263
A S ++ K E LQ E +K Y +LA + L+ ++++ Q E +
Sbjct: 1107 AGTSGSEEVKVLEHKLKEADEMHTLLQLECEK-YKSVLAETEGILQKLQRSVEQ---EEN 1162
Query: 264 EFRRKYEETQKEVHNLNQLLYSQR------RADVQHLEDDRHKTEKIQKLREENDIARGK 317
+++ K +E+ K + + S R++ + +E+ R + E ++ E+ ++ R
Sbjct: 1163 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERST 1222
Query: 318 LEEEKKRSEELLSQVQFL----YTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHV 373
E + ++LL+++Q Y+ ++Q EE + LL+ Q+ E+ +RQ V
Sbjct: 1223 YVTEVRELKDLLTELQKKLDDSYSEAVRQNEE---LNLLKAQLNETLTKLRTEQNERQKV 1279
Query: 374 QHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAAL 433
LH + L +++I + + E + P ETE+ EK ++ + +L
Sbjct: 1280 AGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSP------ETESSEK-----ETMSVSL 1328
Query: 434 NESLVE 439
N+++ +
Sbjct: 1329 NQTVTQ 1334
Score = 61.6 bits (148), Expect = 1e-09
Identities = 102/472 (21%), Positives = 188/472 (39%), Gaps = 85/472 (18%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEITSGKGK---LTDK--ERHRLL----EKIRVLEA--- 68
+ E T++ LK EI LK + + K + +T K E LL E++ ++A
Sbjct: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
Query: 69 EKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVL 128
EKEK+ + +++Q + LKA A L+E + + E + L E+++ L
Sbjct: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQ-HNLKEASSASQFEELEI-VLKEKENEL 942
Query: 129 KQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYD 188
K+ + R ++L SKT L+ Q F S I + + Q + +++ L
Sbjct: 943 KRLEAMLKERESDLSSKTQLLQDVQD-ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI 1001
Query: 189 QQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDL 248
+RE + GL EL+ + H + E E L K
Sbjct: 1002 SEREKEISGLWN---ELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTS 1058
Query: 249 EVERQTITQLSFELSEFRRK-------------------YEETQKEV-------HNLNQL 282
+ +Q + + E E +K +E+ KE + L
Sbjct: 1059 KERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL 1118
Query: 283 LYSQRRADVQH----LEDDRHK-----TEKI-QKLREENDIARGKLEEEKKRSEELLSQV 332
+ + AD H LE +++K TE I QKL+ + K + + S + + Q+
Sbjct: 1119 EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM 1178
Query: 333 QFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLH-------VILKELR 385
Q +TS ++ E ++++ D EN + +R+H++ +L + E+R
Sbjct: 1179 QSSFTSSEQELE----------RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228
Query: 386 KARNQITQL---------ESLKQLHEF-----AITEPLVTFQGETENREKVA 423
+ ++ +T+L E+++Q E + E L + E R+KVA
Sbjct: 1229 ELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVA 1280
Score = 55.1 bits (131), Expect = 1e-07
Identities = 94/447 (21%), Positives = 198/447 (44%), Gaps = 87/447 (19%)
Query: 30 LKGEIAHLKTSVDEITSGKGKLTDKERHRLL--EKIRVLEAEKEKNAYQLTEKDKEIQRL 87
LK E+ L+ +E + +L ++ + +KIR+LE E+ ++++ K +E + L
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE---EQLQHEISNKMEEFKIL 703
Query: 88 RDQLKARYSTTA-------------LLEQLEETTREGERREQVLKAL-----------SE 123
DQ KA S ++EQ+E+ +E + + + ++ L E
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
Query: 124 EKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALE---- 179
E + ++ + S+ T + +L++K N Q + IHE + ++K E
Sbjct: 764 ELNAIRTENSSLTKEVQDLKAKQN----DQVSFASLVEELKKVIHEKDGKIKSVEELLEA 819
Query: 180 -----KNQQWLVYDQQREVYVKGLLAKI--FELEKKTETAAHSLPQQTK-----KPESEG 227
N++ V D ++E +K L +I +LEK + + S Q+ + K E
Sbjct: 820 ELLKVANKEKTVQDLKQE--IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMN 877
Query: 228 YLQ---EEKQKCYNDLLASAK--KDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQL 282
++ EEK+K DL + K +DL+ E +++ E+++ K + + L ++
Sbjct: 878 TMKAVLEEKEK---DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEEL-EI 933
Query: 283 LYSQRRADVQHLE--------DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQF 334
+ ++ +++ LE D KT+ +Q +++EN + + ++E+ L Q +
Sbjct: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ--------LKQQNY 985
Query: 335 LYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQL 394
S EE +V + E++ + L E + L + V+HQ RK N + +
Sbjct: 986 QQASSFPPHEELLKV-ISEREKEISGLWNELDSL-KDAVEHQ--------RKKNNDLRE- 1034
Query: 395 ESLKQLHEFAITEPLVTFQGETENREK 421
++ + + A TE ++ + ++E+
Sbjct: 1035 KNWEAMEALASTEKMLQDKVNKTSKER 1061
Score = 33.9 bits (76), Expect = 0.32
Identities = 49/243 (20%), Positives = 96/243 (39%), Gaps = 39/243 (16%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K ++ L + +G + L+ SV++ K K+ E H+ +++++ E+ +L ++
Sbjct: 1138 KYKSVLAETEGILQKLQRSVEQ-EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1196
Query: 82 KEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAE 141
K+I+ LR RE E E L+ E+ ++ + E
Sbjct: 1197 KDIENLR--------------------REREHLEMELEKAEMERSTYVTEVRELKDLLTE 1236
Query: 142 LESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAK 201
L+ K + S+ V N ++ ++ QL + L K L +Q V G L K
Sbjct: 1237 LQKKLDD-SYSEAVRQN------EELNLLKAQLNETLTK----LRTEQNERQKVAGDLHK 1285
Query: 202 IFE----LEKKTETAAHS---LPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQT 254
+ ++ K AA + PE+E +E N + ++ L+ Q
Sbjct: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345
Query: 255 ITQ 257
+T+
Sbjct: 1346 LTK 1348
>gi|118498368 kinectin 1 isoform c [Homo sapiens]
Length = 1300
Score = 71.2 bits (173), Expect = 2e-12
Identities = 106/463 (22%), Positives = 201/463 (43%), Gaps = 71/463 (15%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K + E+++ EIAHLK + T++ + ++ L + + +LTEK
Sbjct: 407 KFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKT 466
Query: 82 KEIQRLRDQLK-ARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLS----AAT 136
++Q+ Q K A + T L QL+E R E + ++ + E + +Q L A
Sbjct: 467 GKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE 526
Query: 137 SRIAELESK-TNTLRLSQTVAPNCF------NSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
+ + L SK T+TL Q + +N +++Q++D LE+N+ Q
Sbjct: 527 NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQ 586
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
Q F + +T+A L ++ K +E ++++ K D LAS
Sbjct: 587 Q------------FHSQIAAQTSASVLAEELHKVIAE---KDKQIKQTEDSLAS------ 625
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRH----KTEKIQ 305
ER +T EL + + + EV L Q L +++ A LE + K +KI+
Sbjct: 626 -ERDRLTSKEEELKDIQNMNFLLKAEVQKL-QALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 306 KLRE--ENDIARGKLEEEK---KRSEELLSQVQFLYTSLLKQ-------------QEEQT 347
L E +++I+ K+EE K +++ L S+VQ L T + +Q QE+
Sbjct: 684 LLEEQLQHEIS-NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDE 742
Query: 348 RVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELR----KARNQI---TQLESLKQ- 399
++ +E+ ++ + ++ + ++ + + KE++ K +Q+ + +E LK+
Sbjct: 743 KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV 802
Query: 400 LHE-----FAITEPLVTFQGETENREKVAASPKSPTAALNESL 437
+HE ++ E L + N+EK K AL E +
Sbjct: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
Score = 59.7 bits (143), Expect = 5e-09
Identities = 105/469 (22%), Positives = 191/469 (40%), Gaps = 66/469 (14%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEITSGKGK---LTDK--ERHRLL----EKIRVLEA--- 68
+ E T++ LK EI LK + + K + +T K E LL E++ ++A
Sbjct: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
Query: 69 EKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVL 128
EKEK+ + +++Q + LKA A L+E + + E + L E+++ L
Sbjct: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQ-HNLKEASSASQFEELEI-VLKEKENEL 942
Query: 129 KQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYD 188
K+ + R ++L SKT L+ Q F S I + + Q + +++ L
Sbjct: 943 KRLEAMLKERESDLSSKTQLLQDVQD-ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI 1001
Query: 189 QQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQK------------C 236
+RE + GL ++ L+ E ++ ++ E+ +E K
Sbjct: 1002 SEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1061
Query: 237 YNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQL-------LYSQRRA 289
Y + L +K + E T S E+ K +E E+H L QL + ++
Sbjct: 1062 YGEWLHGFEKKAK-ECMAGTSGSEEVKVLEHKLKEAD-EMHTLLQLECEKYKSVLAETEG 1119
Query: 290 DVQHLE--------------DDRHKTEK-IQKLREENDIARGKLEEEKKRSEELLSQVQF 334
+Q L+ D+ HKT K +Q ++ +L E K E L + +
Sbjct: 1120 ILQKLQRSVEQEENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREH 1179
Query: 335 LYTSLLKQQEEQ----TRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQ 390
L L K + E+ T V L+ Q+ E+ +RQ V LH + L +++
Sbjct: 1180 LEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQSLELIQSK 1239
Query: 391 ITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVE 439
I + + E + P ETE+ EK ++ + +LN+++ +
Sbjct: 1240 IVKAAGDTTVIENSDVSP------ETESSEK-----ETMSVSLNQTVTQ 1277
Score = 56.2 bits (134), Expect = 6e-08
Identities = 83/417 (19%), Positives = 185/417 (44%), Gaps = 68/417 (16%)
Query: 30 LKGEIAHLKTSVDEITSGKGKLTDKERHRLL--EKIRVLEAEKEKNAYQLTEKDKEIQRL 87
LK E+ L+ +E + +L ++ + +KIR+LE E+ ++++ K +E + L
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE---EQLQHEISNKMEEFKIL 703
Query: 88 RDQLKARYSTTA-------------LLEQLEETTREGERREQVLKAL-----------SE 123
DQ KA S ++EQ+E+ +E + + + ++ L E
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
Query: 124 EKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALE---- 179
E + ++ + S+ T + +L++K N Q + IHE + ++K E
Sbjct: 764 ELNAIRTENSSLTKEVQDLKAKQN----DQVSFASLVEELKKVIHEKDGKIKSVEELLEA 819
Query: 180 -----KNQQWLVYDQQREVYVKGLLAKI--FELEKKTETAAHSLPQQTK-----KPESEG 227
N++ V D ++E +K L +I +LEK + + S Q+ + K E
Sbjct: 820 ELLKVANKEKTVQDLKQE--IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMN 877
Query: 228 YLQ---EEKQKCYNDLLASAK--KDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQL 282
++ EEK+K DL + K +DL+ E +++ E+++ K + + L ++
Sbjct: 878 TMKAVLEEKEK---DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEEL-EI 933
Query: 283 LYSQRRADVQHLE--------DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQF 334
+ ++ +++ LE D KT+ +Q +++EN + + ++E+ K+++ + S
Sbjct: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQASSFPP 993
Query: 335 LYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQI 391
L E + ++ L ++ + E+++ Q Q+ + E ++ ++
Sbjct: 994 HEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNERQQQVEAVELEAKEVLKKL 1050
Score = 32.3 bits (72), Expect = 0.94
Identities = 37/179 (20%), Positives = 76/179 (42%), Gaps = 20/179 (11%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K ++ L + +G + L+ SV++ K K+ E H+ +++++ E+ +L ++
Sbjct: 1109 KYKSVLAETEGILQKLQRSVEQ-EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1167
Query: 82 KEIQRLR-------------DQLKARYSTTA--LLEQLEETTREGERREQVLKALSEEKD 126
K+I+ LR + ++ Y T L QL ET + + + ++ +
Sbjct: 1168 KDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLH 1227
Query: 127 VLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWL 185
+Q L S+I + T + S V+P +S M + L + + QQ L
Sbjct: 1228 KAQQSLELIQSKIVKAAGDTTVIENSD-VSPETESSEKET---MSVSLNQTVTQLQQLL 1282
>gi|33620775 kinectin 1 isoform a [Homo sapiens]
Length = 1357
Score = 71.2 bits (173), Expect = 2e-12
Identities = 106/463 (22%), Positives = 201/463 (43%), Gaps = 71/463 (15%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K + E+++ EIAHLK + T++ + ++ L + + +LTEK
Sbjct: 407 KFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKT 466
Query: 82 KEIQRLRDQLK-ARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLS----AAT 136
++Q+ Q K A + T L QL+E R E + ++ + E + +Q L A
Sbjct: 467 GKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE 526
Query: 137 SRIAELESK-TNTLRLSQTVAPNCF------NSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
+ + L SK T+TL Q + +N +++Q++D LE+N+ Q
Sbjct: 527 NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQ 586
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
Q F + +T+A L ++ K +E ++++ K D LAS
Sbjct: 587 Q------------FHSQIAAQTSASVLAEELHKVIAE---KDKQIKQTEDSLAS------ 625
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRH----KTEKIQ 305
ER +T EL + + + EV L Q L +++ A LE + K +KI+
Sbjct: 626 -ERDRLTSKEEELKDIQNMNFLLKAEVQKL-QALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 306 KLRE--ENDIARGKLEEEK---KRSEELLSQVQFLYTSLLKQ-------------QEEQT 347
L E +++I+ K+EE K +++ L S+VQ L T + +Q QE+
Sbjct: 684 LLEEQLQHEIS-NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDE 742
Query: 348 RVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELR----KARNQI---TQLESLKQ- 399
++ +E+ ++ + ++ + ++ + + KE++ K +Q+ + +E LK+
Sbjct: 743 KLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKV 802
Query: 400 LHE-----FAITEPLVTFQGETENREKVAASPKSPTAALNESL 437
+HE ++ E L + N+EK K AL E +
Sbjct: 803 IHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEI 845
Score = 62.4 bits (150), Expect = 8e-10
Identities = 104/486 (21%), Positives = 208/486 (42%), Gaps = 83/486 (17%)
Query: 15 GSKPSNSKSETTLEKLKGEIAH----LKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEK 70
G + + + LE+ + ++A+ L+ +E S K + + +H L E + E+
Sbjct: 871 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 930
Query: 71 EKNAYQLTEKDKEIQRLRDQLKARYST----TALLE-----------QLEETTREGERR- 114
+ L EK+ E++RL LK R S T LL+ Q+E+ ++ ++
Sbjct: 931 LEIV--LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 988
Query: 115 ------EQVLKALSE-EKDV--LKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSIN 165
E++LK +SE EK++ L +L + + K N LR A S+
Sbjct: 989 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1048
Query: 166 NIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKI--------------FELEKKTET 211
+ + K + E+ QQ + + + +K L K+ FE + K
Sbjct: 1049 MLQDKVN--KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1106
Query: 212 AAHSLPQQTK--------KPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELS 263
A S ++ K E LQ E +K Y +LA + L+ ++++ Q E +
Sbjct: 1107 AGTSGSEEVKVLEHKLKEADEMHTLLQLECEK-YKSVLAETEGILQKLQRSVEQ---EEN 1162
Query: 264 EFRRKYEETQKEVHNLNQLLYSQR------RADVQHLEDDRHKTEKIQKLREENDIARGK 317
+++ K +E+ K + + S R++ + +E+ R + E ++ E+ ++ R
Sbjct: 1163 KWKVKVDESHKTIKQMQSSFTSSEQELERLRSENKDIENLRREREHLEMELEKAEMERST 1222
Query: 318 LEEEKKRSEELLSQVQFL----YTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHV 373
E + ++LL+++Q Y+ ++Q EE + LL+ Q+ E+ +RQ V
Sbjct: 1223 YVTEVRELKDLLTELQKKLDDSYSEAVRQNEE---LNLLKAQLNETLTKLRTEQNERQKV 1279
Query: 374 QHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAAL 433
LH + L +++I + + E + P ETE+ EK ++ + +L
Sbjct: 1280 AGDLHKAQQSLELIQSKIVKAAGDTTVIENSDVSP------ETESSEK-----ETMSVSL 1328
Query: 434 NESLVE 439
N+++ +
Sbjct: 1329 NQTVTQ 1334
Score = 61.6 bits (148), Expect = 1e-09
Identities = 102/472 (21%), Positives = 188/472 (39%), Gaps = 85/472 (18%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEITSGKGK---LTDK--ERHRLL----EKIRVLEA--- 68
+ E T++ LK EI LK + + K + +T K E LL E++ ++A
Sbjct: 825 ANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLE 884
Query: 69 EKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVL 128
EKEK+ + +++Q + LKA A L+E + + E + L E+++ L
Sbjct: 885 EKEKDLANTGKWLQDLQEENESLKAHVQEVAQ-HNLKEASSASQFEELEI-VLKEKENEL 942
Query: 129 KQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYD 188
K+ + R ++L SKT L+ Q F S I + + Q + +++ L
Sbjct: 943 KRLEAMLKERESDLSSKTQLLQDVQD-ENKLFKSQIEQLKQQNYQQASSFPPHEELLKVI 1001
Query: 189 QQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDL 248
+RE + GL EL+ + H + E E L K
Sbjct: 1002 SEREKEISGLWN---ELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTS 1058
Query: 249 EVERQTITQLSFELSEFRRK-------------------YEETQKEV-------HNLNQL 282
+ +Q + + E E +K +E+ KE + L
Sbjct: 1059 KERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECMAGTSGSEEVKVL 1118
Query: 283 LYSQRRADVQH----LEDDRHK-----TEKI-QKLREENDIARGKLEEEKKRSEELLSQV 332
+ + AD H LE +++K TE I QKL+ + K + + S + + Q+
Sbjct: 1119 EHKLKEADEMHTLLQLECEKYKSVLAETEGILQKLQRSVEQEENKWKVKVDESHKTIKQM 1178
Query: 333 QFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLH-------VILKELR 385
Q +TS ++ E ++++ D EN + +R+H++ +L + E+R
Sbjct: 1179 QSSFTSSEQELE----------RLRSENKDIENLRREREHLEMELEKAEMERSTYVTEVR 1228
Query: 386 KARNQITQL---------ESLKQLHEF-----AITEPLVTFQGETENREKVA 423
+ ++ +T+L E+++Q E + E L + E R+KVA
Sbjct: 1229 ELKDLLTELQKKLDDSYSEAVRQNEELNLLKAQLNETLTKLRTEQNERQKVA 1280
Score = 55.1 bits (131), Expect = 1e-07
Identities = 94/447 (21%), Positives = 198/447 (44%), Gaps = 87/447 (19%)
Query: 30 LKGEIAHLKTSVDEITSGKGKLTDKERHRLL--EKIRVLEAEKEKNAYQLTEKDKEIQRL 87
LK E+ L+ +E + +L ++ + +KIR+LE E+ ++++ K +E + L
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE---EQLQHEISNKMEEFKIL 703
Query: 88 RDQLKARYSTTA-------------LLEQLEETTREGERREQVLKAL-----------SE 123
DQ KA S ++EQ+E+ +E + + + ++ L E
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
Query: 124 EKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALE---- 179
E + ++ + S+ T + +L++K N Q + IHE + ++K E
Sbjct: 764 ELNAIRTENSSLTKEVQDLKAKQN----DQVSFASLVEELKKVIHEKDGKIKSVEELLEA 819
Query: 180 -----KNQQWLVYDQQREVYVKGLLAKI--FELEKKTETAAHSLPQQTK-----KPESEG 227
N++ V D ++E +K L +I +LEK + + S Q+ + K E
Sbjct: 820 ELLKVANKEKTVQDLKQE--IKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMN 877
Query: 228 YLQ---EEKQKCYNDLLASAK--KDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQL 282
++ EEK+K DL + K +DL+ E +++ E+++ K + + L ++
Sbjct: 878 TMKAVLEEKEK---DLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEEL-EI 933
Query: 283 LYSQRRADVQHLE--------DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQF 334
+ ++ +++ LE D KT+ +Q +++EN + + ++E+ L Q +
Sbjct: 934 VLKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQ--------LKQQNY 985
Query: 335 LYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQL 394
S EE +V + E++ + L E + L + V+HQ RK N + +
Sbjct: 986 QQASSFPPHEELLKV-ISEREKEISGLWNELDSL-KDAVEHQ--------RKKNNDLRE- 1034
Query: 395 ESLKQLHEFAITEPLVTFQGETENREK 421
++ + + A TE ++ + ++E+
Sbjct: 1035 KNWEAMEALASTEKMLQDKVNKTSKER 1061
Score = 33.9 bits (76), Expect = 0.32
Identities = 49/243 (20%), Positives = 96/243 (39%), Gaps = 39/243 (16%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K ++ L + +G + L+ SV++ K K+ E H+ +++++ E+ +L ++
Sbjct: 1138 KYKSVLAETEGILQKLQRSVEQ-EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1196
Query: 82 KEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAE 141
K+I+ LR RE E E L+ E+ ++ + E
Sbjct: 1197 KDIENLR--------------------REREHLEMELEKAEMERSTYVTEVRELKDLLTE 1236
Query: 142 LESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAK 201
L+ K + S+ V N ++ ++ QL + L K L +Q V G L K
Sbjct: 1237 LQKKLDD-SYSEAVRQN------EELNLLKAQLNETLTK----LRTEQNERQKVAGDLHK 1285
Query: 202 IFE----LEKKTETAAHS---LPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQT 254
+ ++ K AA + PE+E +E N + ++ L+ Q
Sbjct: 1286 AQQSLELIQSKIVKAAGDTTVIENSDVSPETESSEKETMSVSLNQTVTQLQQLLQAVNQQ 1345
Query: 255 ITQ 257
+T+
Sbjct: 1346 LTK 1348
>gi|156104908 myosin heavy chain 6 [Homo sapiens]
Length = 1939
Score = 70.9 bits (172), Expect = 2e-12
Identities = 104/454 (22%), Positives = 189/454 (41%), Gaps = 72/454 (15%)
Query: 28 EKLKGEIAHLKTSVDEITSG-----KGKLTDKERHRLLE------KIRVLEAEKEKN--- 73
+KL+ E + K +D++TS K K ++ R LE ++++ EA++ N
Sbjct: 1217 QKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFT 1276
Query: 74 -------------AYQLTEKDKEIQRL-RDQLKARYSTTALLEQLEETTREGERREQVLK 119
A QL EK+ I +L R +L L QLEE + L+
Sbjct: 1277 TQRAKLQTENGELARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQ 1336
Query: 120 ALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALE 179
+ + D+L++Q T AEL+ + + + VA + I E +L++A +
Sbjct: 1337 SARHDCDLLREQYEEETEAKAELQRVLS--KANSEVAQWRTKYETDAIQRTE-ELEEAKK 1393
Query: 180 KNQQWLVYDQQREVYVKGLLAKIFELEK---KTETAAHSLPQQTKKPESEGYLQEEKQKC 236
K Q L Q E V+ + AK LEK + + L ++ + ++KQ+
Sbjct: 1394 KLAQRL---QDAEEAVEAVNAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRN 1450
Query: 237 YNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRA---DVQH 293
++ +LA K+ E E + + E +QKE +L+ L+ + A ++H
Sbjct: 1451 FDKILAEWKQKYE--------------ESQSELESSQKEARSLSTELFKLKNAYEESLEH 1496
Query: 294 LEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLE 353
LE + + + +Q+ E +D+ +L E K E L++ +Q V LE
Sbjct: 1497 LETFKRENKNLQE--EISDLTE-QLGEGGKNVHE------------LEKVRKQLEVEKLE 1541
Query: 354 QQ--MQACTLDFENEKLDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAITEPLV 410
Q ++ E+E+ Q + + I E+ RK + ++E K+ H+ +
Sbjct: 1542 LQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKDEEMEQAKRNHQRVVDSLQT 1601
Query: 411 TFQGETENREKVAASPKSPTAALNESLVECPKCN 444
+ ET +R +V K LNE ++ N
Sbjct: 1602 SLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHAN 1635
Score = 53.9 bits (128), Expect = 3e-07
Identities = 94/445 (21%), Positives = 184/445 (41%), Gaps = 90/445 (20%)
Query: 20 NSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRV---LEAEKE----- 71
++++E + +K E +K ++++ + + +L +K L EK + ++AE++
Sbjct: 844 SAETEKEMATMKEEFGRIKETLEKSEARRKELEEKMVSLLQEKNDLQLQVQAEQDNLNDA 903
Query: 72 --------KNAYQLTEKDKEI-QRLRDQLKARYSTTALLEQLEETTREGERR----EQVL 118
KN QL K KE+ +RL D+ + TA +LE+ E ++ E L
Sbjct: 904 EERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKKDIDDLELTL 963
Query: 119 KALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDAL 178
+ +EK + ++ T +A L+ I ++ + K
Sbjct: 964 AKVEKEKHATENKVKNLTEEMAGLDEI---------------------IAKLTKEKKALQ 1002
Query: 179 EKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYN 238
E +QQ L Q E V L +LE++ + + EG L++EK K
Sbjct: 1003 EAHQQALDDLQVEEDKVNSLSKSKVKLEQQVD-------------DLEGSLEQEK-KVRM 1048
Query: 239 DLLASAKK---DLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLE 295
DL + +K DL++ +++I L + + K ++ + +++ N +E
Sbjct: 1049 DLERAKRKLEGDLKLTQESIMDLENDKLQLEEKLKKKEFDINQQNS-----------KIE 1097
Query: 296 DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQ 355
D++ ++QK +EN +LEEE + ++V+ L + L ++ EE + LE+
Sbjct: 1098 DEQVLALQLQKKLKENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISE--RLEEA 1155
Query: 356 MQACTLDFENEK------------LDRQHVQHQLHVILKELRKARN------QITQLESL 397
A ++ E K L+ +QH+ + A + QI L+ +
Sbjct: 1156 GGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRV 1215
Query: 398 KQLHEFAITEPLVTFQGETENREKV 422
KQ E +E + T N E++
Sbjct: 1216 KQKLEKEKSEFKLELDDVTSNMEQI 1240
Score = 53.5 bits (127), Expect = 4e-07
Identities = 112/517 (21%), Positives = 211/517 (40%), Gaps = 92/517 (17%)
Query: 20 NSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAE---------- 69
N++ KL+ E + LK +D++ K+ +KE+H K++ L E
Sbjct: 935 NAELTAKKRKLEDECSELKKDIDDLELTLAKV-EKEKHATENKVKNLTEEMAGLDEIIAK 993
Query: 70 --KEKNAYQLTEKDK--EIQRLRDQLKARYSTTALLEQ-LEETTREGERREQVLKALSEE 124
KEK A Q + ++Q D++ + + LEQ +++ E+ ++V L
Sbjct: 994 LTKEKKALQEAHQQALDDLQVEEDKVNSLSKSKVKLEQQVDDLEGSLEQEKKVRMDLERA 1053
Query: 125 KDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCF-----NSSINNIHEMEIQLKDALE 179
K L+ L I +LE+ + L+L + + F NS I + + +QL+ L+
Sbjct: 1054 KRKLEGDLKLTQESIMDLEN--DKLQLEEKLKKKEFDINQQNSKIEDEQVLALQLQKKLK 1111
Query: 180 KNQQWLV-----YDQQREVYVK------GLLAKIFELEKKTETAAHSLPQQ---TKKPES 225
+NQ + + +R K L ++ E+ ++ E A + Q KK E+
Sbjct: 1112 ENQARIEELEEELEAERTARAKVEKLRSDLSRELEEISERLEEAGGATSVQIEMNKKREA 1171
Query: 226 E----------GYLQEEK-----QKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYE 270
E LQ E +K + D +A + ++ ++ +L E SEF+ + +
Sbjct: 1172 EFQKMRRDLEEATLQHEATAAALRKKHADSVAELGEQIDNLQRVKQKLEKEKSEFKLELD 1231
Query: 271 ETQKEVHNLNQLLYSQRRADV--QHLEDD----RHKTEKIQKLREENDIARGKLEEEK-- 322
+ N+ Q++ ++ + + LED R K E+ Q+ + R KL+ E
Sbjct: 1232 DVTS---NMEQIIKAKANLEKVSRTLEDQANEYRVKLEEAQRSLNDFTTQRAKLQTENGE 1288
Query: 323 -----KRSEELLSQV---QFLYT----SLLKQQEEQTRVA-LLEQQMQACTLDFENEKLD 369
+ E L+SQ+ + YT L +Q EE+ + L +Q+ D + +
Sbjct: 1289 LARQLEEKEALISQLTRGKLSYTQQMEDLKRQLEEEGKAKNALAHALQSARHDCDLLREQ 1348
Query: 370 RQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSP 429
+ + + L KA +++ Q + + TE L E ++K+A +
Sbjct: 1349 YEEETEAKAELQRVLSKANSEVAQWRTKYETDAIQRTEEL------EEAKKKLAQRLQDA 1402
Query: 430 TAALNESLVECPKCNIQYPATEHR------DLLVHVE 460
A+ +C T+HR DL+V VE
Sbjct: 1403 EEAVEAVNAKCSSLE----KTKHRLQNEIEDLMVDVE 1435
Score = 51.6 bits (122), Expect = 1e-06
Identities = 74/414 (17%), Positives = 161/414 (38%), Gaps = 43/414 (10%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K+ LEK++ ++ K + + E ++L K + +L EKD
Sbjct: 1523 KNVHELEKVRKQLEVEKLELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLAEKD 1582
Query: 82 KEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAE 141
+E+++ + + +L L+ TR +V K + + + ++ QLS A AE
Sbjct: 1583 EEMEQAKRNHQR--VVDSLQTSLDAETRSRNEVLRVKKKMEGDLNEMEIQLSHANRMAAE 1640
Query: 142 LESKTNTLR-------------------LSQTVA-----PNCFNSSINNIHEMEIQLKDA 177
+ + +L+ L + +A N + + + + Q + +
Sbjct: 1641 AQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQTERS 1700
Query: 178 LEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCY 237
+ +Q L+ +R + + +KK E+ L + ++ E EEK K
Sbjct: 1701 RKLAEQELIETSERVQLLHSQNTSLINQKKKMESDLTQLQSEVEEAVQECRNAEEKAKKA 1760
Query: 238 NDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDD 297
A ++L+ E+ T S L ++ E+T K++ Q R D
Sbjct: 1761 ITDAAMMAEELKKEQDT----SAHLERMKKNMEQTIKDL---------QHRLDEAEQIAL 1807
Query: 298 RHKTEKIQKLREENDIARGKLEEEKKRSEE----LLSQVQFLYTSLLKQQEEQTRVALLE 353
+ +++QKL G+LE E+KR+ E + + + + +E++ + L+
Sbjct: 1808 KGGKKQLQKLEARVRELEGELEAEQKRNAESVKGMRKSERRIKELTYQTEEDKKNLLRLQ 1867
Query: 354 QQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITE 407
+ L + K + + Q + L + RK ++++ + E + E + +
Sbjct: 1868 DLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1921
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 70.1 bits (170), Expect = 4e-12
Identities = 88/406 (21%), Positives = 183/406 (45%), Gaps = 39/406 (9%)
Query: 26 TLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQ 85
TLE + EIA L++ + ++T+ +L +E+ E+ E EK + Q TE+ + +
Sbjct: 376 TLEMKEEEIAQLRSRIKQMTTQGEEL--REQKEKSERAAFEELEKALSTAQKTEEAR--R 431
Query: 86 RLRDQLKARYSTTALLEQLEETTREGER---REQVLKALSEEKDVLKQQLSAATSRIAEL 142
+L+ ++ + T E T E ER ++++ + E DV+K+ +++ +L
Sbjct: 432 KLKAEMDEQIKTI-------EKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKL 484
Query: 143 ESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKI 202
K R Q + E + Q+K ALEK+Q + Q + + L +
Sbjct: 485 HEK-ELARKEQELTKKLQTRE----REFQEQMKVALEKSQSEYLKISQEKEQQESLALEE 539
Query: 203 FELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFEL 262
EL+KK + + E+E Y + +L +S +K L+ + L+ L
Sbjct: 540 LELQKKAILTESENKLRDLQQEAETY-----RTRILELESSLEKSLQENKNQSKDLAVHL 594
Query: 263 SEFRRKYEETQKEVHNLN-QLLYSQRRADVQHL--EDDRHKTEKIQKLREENDIARGKLE 319
E +K HN ++ + + +++ L + D TEK+Q L+++ KL
Sbjct: 595 --------EAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLR 646
Query: 320 EE-KKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFE-NEKLDRQH-VQHQ 376
E+ ++ E LL + ++ + +++ E+T L +Q + +L E +E L +H ++ +
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 377 LHVILKELRKARNQI-TQLESLKQLHEFAITEPLVTFQGETENREK 421
L V+ + K + ++ +++ K H+ + + + + EK
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEK 752
Score = 65.1 bits (157), Expect = 1e-10
Identities = 105/473 (22%), Positives = 198/473 (41%), Gaps = 92/473 (19%)
Query: 2 SSRSTKDLIKSKWGSKPSNSKSETTL-EKLKGEIAHLKTSVDEITSGKGKLTDKERHRLL 60
+ +KDL K ++K T + EK K E+ LK D + + K ++ ++ +
Sbjct: 583 NKNQSKDLAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLKQQYQTEM 642
Query: 61 EKIRVLEAEKEKNAYQLTEKDKEI----------QRLRDQLKARYSTT-ALLEQLEETTR 109
EK+R + E+EK KDKEI ++ ++L + + +L +L E +
Sbjct: 643 EKLRE-KCEQEKETLL---KDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLK 698
Query: 110 EGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHE 169
+ E+ L L ++ D +KQ+L A +++ + N Q V SI HE
Sbjct: 699 ARHKLEEELSVLKDQTDKMKQELEA------KMDEQKN--HHQQQV------DSIIKEHE 744
Query: 170 MEIQLKDALEKNQ--QWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPE--- 224
+ IQ + K+Q Q + ++R+ ++K A + LE + + L Q + K +
Sbjct: 745 VSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASAKLDVFQ 804
Query: 225 SEGYLQEEKQKCYNDLLASAKK---DLEVERQTITQLSFELSEFRRKY------------ 269
S E+ K Y + LA ++ DLE ER +T+ E+ ++
Sbjct: 805 SYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTELDAHKIQVQ 864
Query: 270 ---EETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSE 326
++ +K+ + Q + S + LED + E+ +++ E + ++ E +K+
Sbjct: 865 DLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEI 924
Query: 327 ELLSQ--------VQFL---YTSLLKQQE--------------EQTRVALLEQQMQACTL 361
E+L+Q + L Y + K QE E + LL+Q+ +
Sbjct: 925 EILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAK-LKK 983
Query: 362 DFENEKLDRQHVQHQLHVILKELRKAR-------------NQITQLESLKQLH 401
+ EN L+ + Q + + E+ +A NQ Q+ESL ++H
Sbjct: 984 ELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQIESLTEVH 1036
Score = 58.9 bits (141), Expect = 9e-09
Identities = 78/367 (21%), Positives = 168/367 (45%), Gaps = 38/367 (10%)
Query: 61 EKIRVLE---AEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQV 117
EKI VL+ EKEK ++ ++ +E +++ +Y + +LE + + +
Sbjct: 1736 EKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLI--KLEHAEAKQHEDQSM 1793
Query: 118 LKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQ---L 174
+ L EE + ++ S ++ E E N ++ Q + N F+ + E E+ L
Sbjct: 1794 IGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLE-NVFDDVQKTLQEKELTCQIL 1852
Query: 175 KDALEKNQQWLVYDQQREVY---VKGLLAKIFELE---------KKTETAAHSLPQQTKK 222
+ +++ LV +Q+EV+ ++ L +K +L+ K TE + +++K
Sbjct: 1853 EQKIKELDSCLV--RQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKS 1910
Query: 223 PESEGYLQEEKQKCYNDL---LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNL 279
+ L + +NDL LA A+++ + + I +L +L R+++ Q+E+ L
Sbjct: 1911 HLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEH---QQELEIL 1967
Query: 280 NQLLYSQRRADVQHLEDD---RHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLY 336
+ +R ++ ++D +H + Q +RE N K +E + +E +++ Q +
Sbjct: 1968 KKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVE 2027
Query: 337 TSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKEL-RKARNQITQLE 395
LL+ +E+T Q ++ ++ K + + L +E+ K R+ TQLE
Sbjct: 2028 AELLESHQEET-----NQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLE 2082
Query: 396 SLKQLHE 402
L++ ++
Sbjct: 2083 ELQKKYQ 2089
Score = 54.7 bits (130), Expect = 2e-07
Identities = 80/335 (23%), Positives = 147/335 (43%), Gaps = 50/335 (14%)
Query: 101 LEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCF 160
++ LE + +R+E +LK E K+Q + TS L+ + + RL +
Sbjct: 278 VKTLETLQQRVKRQENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDE-RLQEL------ 330
Query: 161 NSSINNIHEME-----IQLKDA------LEKNQQWLVYDQQREVYV-----KGLLAKIFE 204
I ++H E QL+DA LE+++ ++ + +R+++ + +A++
Sbjct: 331 -EKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRS 389
Query: 205 LEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSE 264
K+ T L +Q +K E + + EK L++A+K E R+ L E+ E
Sbjct: 390 RIKQMTTQGEELREQKEKSERAAFEELEKA------LSTAQKTEEARRK----LKAEMDE 439
Query: 265 FRRKYEETQKEVHNLNQLLYSQRRADVQHL--EDDRHKTEKIQKLREENDIARGKLEEEK 322
+ E+T +E Q S+ + +V + + + K+QKL E+ ++AR + E K
Sbjct: 440 QIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEK-ELARKEQELTK 498
Query: 323 K---RSEELL---------SQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDR 370
K R E SQ ++L S K+Q+E + LE Q +A + EN+ D
Sbjct: 499 KLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTESENKLRDL 558
Query: 371 QHVQHQLHVILKELRKARNQITQLESLKQLHEFAI 405
Q + EL + + Q E+ Q + A+
Sbjct: 559 QQEAETYRTRILELESSLEKSLQ-ENKNQSKDLAV 592
Score = 53.1 bits (126), Expect = 5e-07
Identities = 101/489 (20%), Positives = 195/489 (39%), Gaps = 62/489 (12%)
Query: 17 KPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRV-LEAEKEKNAY 75
K K +TTL +L+ ++ V+ + + KL + H LEK+ V L ++N +
Sbjct: 1098 KEEGVKQDTTLNELQEQLKQKSAHVNSLAQDETKL---KAH--LEKLEVDLNKSLKENTF 1152
Query: 76 ---------QLTEKDKEIQRLRDQLKARYSTT-----ALLEQLEETTREGERREQVLKAL 121
L E+DK R +L ++ TT +L E++ + E + K L
Sbjct: 1153 LQEQLVELKMLAEEDK---RKVSELTSKLKTTDEEFQSLKSSHEKSNKSLEDKSLEFKKL 1209
Query: 122 SEEKDVLKQQLSAATSRI-AELESKTNTLRLSQTVAPNCFNSSINN-------------- 166
SEE L QL + A LE+KTN L + N S I++
Sbjct: 1210 SEE---LAIQLDICCKKTEALLEAKTNELINISSSKTNAILSRISHCQHRTTKVKEALLI 1266
Query: 167 ----IHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKK 222
+ E+E QL+ E+ + QQ ++ +I ++ E+ K+
Sbjct: 1267 KTCTVSELEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEALQKE 1326
Query: 223 PESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNL--- 279
++ EK+ C L KK+L +T + EL E + + K++ +L
Sbjct: 1327 GGNQQQAASEKESCITQL----KKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQ 1382
Query: 280 --NQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYT 337
N + S++ A + L ++ EK + L + D++ K++ K L QV
Sbjct: 1383 LQNSISLSEKEAAISSLR-KQYDEEKCELLDQVQDLS-FKVDTLSKEKISALEQVDDWSN 1440
Query: 338 SLLK-QQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQIT---- 392
+ +++ Q+R + ++ + E + + Q++++ +EL + +
Sbjct: 1441 KFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKG 1500
Query: 393 QLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPATEH 452
++E K E + + +T ++ T + ESL E K Q EH
Sbjct: 1501 EMEDDKSKMEKKESNLETELKSQTARIMELEDHITQKTIEI-ESLNEVLKNYNQQKDIEH 1559
Query: 453 RDLLVHVEY 461
++L+ +++
Sbjct: 1560 KELVQKLQH 1568
Score = 52.0 bits (123), Expect = 1e-06
Identities = 108/497 (21%), Positives = 197/497 (39%), Gaps = 105/497 (21%)
Query: 11 KSKWGSKPSNSKSETTLEKLKGEIAHLKT----------SVDEITSGKGKLTDKERHRLL 60
KSK K SN ET L+ I L+ S++E+ + D E L+
Sbjct: 1506 KSKMEKKESNL--ETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELV 1563
Query: 61 EKI------------RVLEAEK-----EKNAY----QLTEKDKEIQRLRDQLKARYSTTA 99
+K+ RV EAE+ E Y +L K KE++ + +K++
Sbjct: 1564 QKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSKEEELK 1623
Query: 100 LLE---------QLEETTREGER-----REQVLKALSEEKDVLKQ----QLSAATSRIAE 141
LE +L E R+ E+ ++Q+L + E+++ K+ LS +++ E
Sbjct: 1624 ALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQE 1683
Query: 142 -------LESKTNTLRLSQT---VAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQR 191
LE K ++ SQ+ + P + + E + ++K + + QR
Sbjct: 1684 REREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKISVLQR 1743
Query: 192 EVYVKGLLAKIFELEKKTETAA----------------HSLPQQTKKPESEGYLQ---EE 232
+ K L + EK+ ++ H+ +Q + G+LQ EE
Sbjct: 1744 NLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEELEE 1803
Query: 233 KQKCYNDLLA------------SAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLN 280
K K Y+ ++A AK++LE + L E + ++++ L+
Sbjct: 1804 KNKKYSLIVAQHVEKEGGKNNIQAKQNLE---NVFDDVQKTLQEKELTCQILEQKIKELD 1860
Query: 281 QLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLL 340
L Q+ +E+ K EK+Q L++ + R K E + + E S+ + LL
Sbjct: 1861 SCLVRQKEVHRVEMEELTSKYEKLQALQQMD--GRNKPTELLEENTEEKSKSHLVQPKLL 1918
Query: 341 KQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQL 400
E Q + + + + E +KL ++ V +L L+ LRK Q +LE LK+
Sbjct: 1919 SNMEAQHN----DLEFKLAGAEREKQKLGKEIV--RLQKDLRMLRKEHQQ--ELEILKKE 1970
Query: 401 HEFAITEPLVTFQGETE 417
++ E + Q + E
Sbjct: 1971 YDQEREEKIKQEQEDLE 1987
Score = 48.9 bits (115), Expect = 1e-05
Identities = 84/393 (21%), Positives = 166/393 (42%), Gaps = 54/393 (13%)
Query: 30 LKGEIAHLKTSVDEITSG--KGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEI-QR 86
+K E A K D+ G + +L +K + L + +E E KN Q + + +
Sbjct: 1778 IKLEHAEAKQHEDQSMIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDD 1837
Query: 87 LRDQLKARYSTTALLEQ-LEET----TREGERREQVLKALSEEKDVLK--QQLSAATSRI 139
++ L+ + T +LEQ ++E R+ E ++ L+ + + L+ QQ+
Sbjct: 1838 VQKTLQEKELTCQILEQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPT 1897
Query: 140 AELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLL 199
LE T S V P ++ +++E +L A + Q+ L
Sbjct: 1898 ELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQK--------------LG 1943
Query: 200 AKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQ-TITQL 258
+I L+K Q+ + + E Y QE ++K + ++DLE++ T+ QL
Sbjct: 1944 KEIVRLQKDLRMLRKEHQQELEILKKE-YDQEREEK-----IKQEQEDLELKHNSTLKQL 1997
Query: 259 SFELSEFRRKYEETQKEVH-NLNQLLYSQRRADVQHLEDDRHKTEKIQK--LREENDIAR 315
+ EF + + ++E+ + + + + + + LE + +T ++ K +++D+ R
Sbjct: 1998 ---MREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEETNQLLKKIAEKDDDLKR 2054
Query: 316 GKLEEEK---KRSEELLSQVQFLYTSL----------LKQQEE--QTRVALLEQQMQAC- 359
E+ R EE+ ++V+ L T L L+Q+E V ++E Q Q
Sbjct: 2055 TAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPGNDNVTIMELQTQLAQ 2114
Query: 360 -TLDFENEKLDRQHVQHQLHVILKELRKARNQI 391
T + KL Q + Q+H + L+K +
Sbjct: 2115 KTTLISDSKLKEQEFREQIHNLEDRLKKYEKNV 2147
>gi|150010558 myosin, heavy polypeptide 15 [Homo sapiens]
Length = 1946
Score = 69.7 bits (169), Expect = 5e-12
Identities = 85/416 (20%), Positives = 177/416 (42%), Gaps = 45/416 (10%)
Query: 21 SKSETTLEKLKGEIAHLKTSVD-EITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTE 79
+K+ T +EK+K I KT V + +G L E L ++ +LEA+ E +L+E
Sbjct: 1532 TKNLTEMEKVKKLIEEEKTEVQVTLEETEGALERNESKILHFQLELLEAKAELER-KLSE 1590
Query: 80 KDKEIQRLR-------DQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQL 132
KD+EI+ R D L++ + A + E TR ++ E+ L + + +Q+
Sbjct: 1591 KDEEIENFRRKQQCTIDSLQSSLDSEA--KSRIEVTRLKKKMEEDLNEMELQLSCANRQV 1648
Query: 133 SAATSRIAELESKTNTLR------------LSQTVAP-----NCFNSSINNIHEMEIQLK 175
S AT + +L+ + L+ L + VA + S + ++ ++ Q +
Sbjct: 1649 SEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKEQVAVAERRNSLLQSELEDLRSLQEQTE 1708
Query: 176 DALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQK 235
+++ L+ +R + +KK E + ++ ++ E EEK K
Sbjct: 1709 RGRRLSEEELLEATERINLFYTQNTSLLSQKKKLEADVARMQKEAEEVVQECQNAEEKAK 1768
Query: 236 CYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLE 295
A+ ++L+ ++ TI L + + QK + Q+ R +Q LE
Sbjct: 1769 KAAIEAANLSEELKKKQDTIAHLERTRENMEQTITDLQKRLAEAEQMALMGSRKQIQKLE 1828
Query: 296 DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSL----LKQQEEQTRVAL 351
++RE G+LE E +RS E + L + + +E++ ++
Sbjct: 1829 ---------SRVRE----LEGELEGEIRRSAEAQRGARRLERCIKELTYQAEEDKKNLSR 1875
Query: 352 LEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITE 407
++ QM L +N K + + Q + L + +K ++++ +++ ++ E + +
Sbjct: 1876 MQTQMDKLQLKVQNYKQQVEVAETQANQYLSKYKKQQHELNEVKERAEVAESQVNK 1931
Score = 58.9 bits (141), Expect = 9e-09
Identities = 101/457 (22%), Positives = 199/457 (43%), Gaps = 63/457 (13%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRV-LEAEKEKNAY-QLTEKD 81
E L KL+G + + S++ + S + L ++ R + LE ++ + E EK QL +
Sbjct: 1061 ERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSKVENEKGLVAQLQKTV 1120
Query: 82 KEIQR----LRDQLKARYSTTALLEQ-----LEETTREGERREQVLKALSEEKDVLKQQL 132
KE+Q L+++L+A +T A +E+ ++ ER E+V + + ++ K+Q
Sbjct: 1121 KELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEVGGSSLAQLEITKKQE 1180
Query: 133 SAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQRE 192
+ ++E T +T + + +++ E+E Q+++ + Q+ +
Sbjct: 1181 TKFQKLHRDMEEATLHF---ETTSASLKKRHADSLAELEGQVENLQQVKQKLEKDKSDLQ 1237
Query: 193 VYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVER 252
+ V LL ++ E+ T A++ T E L E K D + DL ++
Sbjct: 1238 LEVDDLLTRV---EQMTRAKANAEKLCTLYEER---LHEATAKL--DKVTQLANDLAAQK 1289
Query: 253 QTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEK--------- 303
T+L E EF R+ EE + ++ L++ ++ + +ED R + EK
Sbjct: 1290 ---TKLWSESGEFLRRLEEKEALINQLSR----EKSNFTRQIEDLRGQLEKETKSQSALA 1342
Query: 304 --IQKLREENDIARGKLEEEKKRSEEL---LSQVQ--------------FLYTSLLKQQE 344
+QK + + D+ R + EEE++ EL LS+V T L+ +
Sbjct: 1343 HALQKAQRDCDLLREQYEEEQEVKAELHRTLSKVNAEMVQWRMKYENNVIQRTEDLEDAK 1402
Query: 345 EQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHV--ILKELRKARNQITQLESLKQLHE 402
++ + L E + N L+R Q QL + L +L K R+ +L+ KQL
Sbjct: 1403 KELAIRLQEAAEAMGVANARNASLERARHQLQLELGDALSDLGKVRSAAARLDQ-KQLQS 1461
Query: 403 FAITEPLVTFQGETENREKVAASPKSPTAALNESLVE 439
+ L ++ + E + + + + AL+ L++
Sbjct: 1462 ---GKALADWKQKHEESQALLDASQKEVQALSTELLK 1495
Score = 58.5 bits (140), Expect = 1e-08
Identities = 91/423 (21%), Positives = 171/423 (40%), Gaps = 76/423 (17%)
Query: 20 NSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQ--- 76
N+ E +L+ E+ + + ++ S +L K+ L+ + L K+K+
Sbjct: 1423 NASLERARHQLQLELGDALSDLGKVRSAAARLDQKQ----LQSGKALADWKQKHEESQAL 1478
Query: 77 LTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAAT 136
L KE+Q L +L +T EE+ E + K L EE L Q+ T
Sbjct: 1479 LDASQKEVQALSTELLKLKNT------YEESIVGQETLRRENKNLQEEISNLTNQVREGT 1532
Query: 137 SRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKD---ALEKNQQWLVYDQQREV 193
+ E+E + +T E+++ L++ ALE+N+ +++ Q +
Sbjct: 1533 KNLTEMEKVKKLIEEEKT--------------EVQVTLEETEGALERNESKILHFQLELL 1578
Query: 194 YVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLAS-----AKKDL 248
K ELE+K K E E + KQ+C D L S AK +
Sbjct: 1579 EAKA------ELERKLSE---------KDEEIENF--RRKQQCTIDSLQSSLDSEAKSRI 1621
Query: 249 EVER------QTITQLSFELSEFRRKYEETQKEVHNLNQLL--YSQRRADVQHLEDD--- 297
EV R + + ++ +LS R+ E K + L + + D L D
Sbjct: 1622 EVTRLKKKMEEDLNEMELQLSCANRQVSEATKSLGQLQIQIKDLQMQLDDSTQLNSDLKE 1681
Query: 298 ------------RHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEE 345
+ + E ++ L+E+ + R EEE + E ++ TSLL Q+++
Sbjct: 1682 QVAVAERRNSLLQSELEDLRSLQEQTERGRRLSEEELLEATERINLFYTQNTSLLSQKKK 1741
Query: 346 -QTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFA 404
+ VA ++++ + + +N + + + + +EL+K ++ I LE ++ E
Sbjct: 1742 LEADVARMQKEAEEVVQECQNAEEKAKKAAIEAANLSEELKKKQDTIAHLERTRENMEQT 1801
Query: 405 ITE 407
IT+
Sbjct: 1802 ITD 1804
Score = 56.6 bits (135), Expect = 5e-08
Identities = 85/364 (23%), Positives = 154/364 (42%), Gaps = 52/364 (14%)
Query: 103 QLEETTREGERREQVLKA----LSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPN 158
QL++ + E + + LKA L++EK+ L QL A +A +E + L S+
Sbjct: 870 QLQKALEKSEFQREELKAKQVSLTQEKNDLILQLQAEQETLANVEEQCEWLIKSKIQLEA 929
Query: 159 CFNSSINNIHEMEIQLKDALEKNQQWL---VYDQQREVYVKGLLAKIFELEKKTETAAHS 215
+ E E ++ L + L ++ ++E+ L + + EK+ T H
Sbjct: 930 RVKELSERVEEEE-EINSELTARGRKLEDECFELKKEI--DDLETMLVKSEKEKRTTEHK 986
Query: 216 LPQQTKKPE-----------SEGYLQEEKQKCYNDL------LAS-AKKDLEVERQTITQ 257
+ T++ E + +QE Q+ +DL L+S +K +L++E+Q + +
Sbjct: 987 VKNLTEEVEFLNEDISKLNRAAKVVQEAHQQTLDDLHMEEEKLSSLSKANLKLEQQ-VDE 1045
Query: 258 LSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGK 317
L L + R+ ++E+H L L R + RH E+++K E K
Sbjct: 1046 LEGALEQERKARMNCERELHKLEGNLKLNRESMENLESSQRHLAEELRKKELELSQMNSK 1105
Query: 318 LEEEKKRSEELLSQVQFLYTSLL----KQQEEQTRVALLEQQMQACTLDFE--NEKLDRQ 371
+E EK +L V+ L T + K + E+T A +E++ T D NE+L+
Sbjct: 1106 VENEKGLVAQLQKTVKELQTQIKDLKEKLEAERTTRAKMERERADLTQDLADLNERLEEV 1165
Query: 372 HVQH--QLHVILKELRKARNQITQLE-----------SLKQLHEFAITEPLVTFQGETEN 418
QL + K+ K + +E SLK+ H + L +G+ EN
Sbjct: 1166 GGSSLAQLEITKKQETKFQKLHRDMEEATLHFETTSASLKKRH----ADSLAELEGQVEN 1221
Query: 419 REKV 422
++V
Sbjct: 1222 LQQV 1225
>gi|55770834 centromere protein F [Homo sapiens]
Length = 3114
Score = 69.7 bits (169), Expect = 5e-12
Identities = 97/405 (23%), Positives = 171/405 (42%), Gaps = 32/405 (7%)
Query: 3 SRSTKDLIKSKWGSKP-SNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLE 61
SRST + K S NS S L++LK + L+ ++E+ + + +KE +
Sbjct: 255 SRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNKINELEL-RLQGHEKEMKGQVN 313
Query: 62 KIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKAL 121
K + L+ + EK +L EK+K + + RD+L TTA Q ++ + + EQ LK L
Sbjct: 314 KFQELQLQLEKAKVELIEKEKVLNKCRDEL---VRTTA---QYDQASTKYTALEQKLKKL 367
Query: 122 SEEKDVLKQQL-SAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEK 180
+E+ +Q SA S +++ K + + F + +M+ +L L++
Sbjct: 368 TEDLSCQRQNAESARCSLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARLTQELQQ 427
Query: 181 NQQW---LVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCY 237
+ L + + VK L E K+ A Q ++ E+E E+ K
Sbjct: 428 AKNMHNVLQAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKE 487
Query: 238 NDLLASAKKD-------LEVERQTITQLSFELSEF--RRKYEETQKEV----------HN 278
N+LL S + LE E + I Q + F K + T +E
Sbjct: 488 NNLLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQ 547
Query: 279 LNQLLYSQRRADVQHLEDDRHKTEKIQKLREEN-DIARGKLEEEKKRSEELLSQVQFLYT 337
N L + + V LE R ++ + K RE + + KL + +K S+ LLS ++
Sbjct: 548 ENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKK 607
Query: 338 SLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILK 382
+ +EE+T + + + + E+EK + Q + L LK
Sbjct: 608 EYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLK 652
Score = 63.2 bits (152), Expect = 5e-10
Identities = 89/407 (21%), Positives = 161/407 (39%), Gaps = 77/407 (18%)
Query: 52 TDKERHRL---LEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLK---------------- 92
T +E H+L +EK+RV EK + EK KE +R D LK
Sbjct: 2110 TQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLERELQMSEEN 2169
Query: 93 ----------ARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAEL 142
++ L Q+EE R + E L L EK+ L +Q+ +++EL
Sbjct: 2170 QELVILDAENSKAEVETLKTQIEEMARSLKVFELDLVTLRSEKENLTKQIQEKQGQLSEL 2229
Query: 143 ESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREV-YVKGLLAK 201
+ ++ F S + + EIQ+K+ K ++ +Q +E+ L
Sbjct: 2230 DKLLSS-----------FKSLLEEKEQAEIQIKEE-SKTAVEMLQNQLKELNEAVAALCG 2277
Query: 202 IFELEKKTETA-------AHSLPQQTKKPESEGYLQEEKQKC----------YNDLL--- 241
E+ K TE + H L +K + E+KQ C + DLL
Sbjct: 2278 DQEIMKATEQSLDPPIEEEHQLRNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGR 2337
Query: 242 -ASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHK 300
+ +++LE+ R + E + + E + ++ + Q L V + +
Sbjct: 2338 VENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENL 2397
Query: 301 TEKIQKLREE-----------NDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRV 349
T ++QK +E +I + K +E+ + E+ + ++ L T L +E RV
Sbjct: 2398 TNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQL---KELNERV 2454
Query: 350 ALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLES 396
A L +AC +N + ++ + +L+ L +A+N L+S
Sbjct: 2455 AALHNDQEACKAKEQNLSSQVECLELEKAQLLQGLDEAKNNYIVLQS 2501
Score = 59.7 bits (143), Expect = 5e-09
Identities = 103/510 (20%), Positives = 200/510 (39%), Gaps = 95/510 (18%)
Query: 7 KDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVL 66
++ ++ K S + +T L++L +A L + + + L+ + LEK ++L
Sbjct: 2427 QEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLELEKAQLL 2486
Query: 67 EA-EKEKNAY-------------------QLTEKDKEIQRLRDQLKARYSTTALLEQLEE 106
+ ++ KN Y +L +KD+EI RL++Q++ + + L Q+E
Sbjct: 2487 QGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEISRLKNQIQDQEQLVSKLSQVEG 2546
Query: 107 TTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPN-------- 158
+ + + L+ L+ E L+Q++ S+ A L+ L+ S N
Sbjct: 2547 EHQLWKEQNLELRNLTVE---LEQKIQVLQSKNASLQDTLEVLQSSYKNLENELELTKMD 2603
Query: 159 --CFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLA---------------K 201
F +N + E +L+ + + Q Q+ K LA +
Sbjct: 2604 KMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQ 2663
Query: 202 IFELEKKTETAAHSLPQQTK-KPESEGYLQE----------EKQKCYNDLLASAKKDLEV 250
+ EL + SL K + E EG ++E E +K + LL K EV
Sbjct: 2664 LKELTLENSELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEV 2723
Query: 251 ERQT-----------ITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRH 299
E QT ++ E+ + EE + Q+L ++ + +L
Sbjct: 2724 EIQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNL----- 2778
Query: 300 KTEKIQKLREENDIARGK----------LEEEKKRSEELLSQVQFLYTSLLKQQEEQTRV 349
+ + +L++EN+ A+GK LEEEK+ ++ LSQ+Q QE+Q
Sbjct: 2779 --KYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQ-------AAQEKQKTG 2829
Query: 350 ALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPL 409
+++ ++ T + + K + + L + +LE K++ E + L
Sbjct: 2830 TVMDTKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQVAH-L 2888
Query: 410 VTFQGETENREKVAASPKSPTAALNESLVE 439
+ Q + ++R P P + S+ E
Sbjct: 2889 CSQQSKQDSRGSPLLGPVVPGPSPIPSVTE 2918
Score = 55.8 bits (133), Expect = 8e-08
Identities = 97/446 (21%), Positives = 182/446 (40%), Gaps = 84/446 (18%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIR--VLEAEKEKNAYQ-- 76
++S+ E++K + +T + ++ K+ +E LEK++ V + EK+++ Q
Sbjct: 517 NQSQNFAEEMKAKNTSQETMLRDLQE---KINQQENSLTLEKLKLAVADLEKQRDCSQDL 573
Query: 77 LTEKDKEIQRLRDQL-KARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAA 135
L +++ I++L D+L K + ALL LE +E E ++ S K ++ L+
Sbjct: 574 LKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSCWKSENEKLLTQM 633
Query: 136 TSRIAELESKTNTLRL---SQTVAPNCFNS--------------SINNIH--------EM 170
S L+SK N L +Q + + +N I N+H E+
Sbjct: 634 ESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRNLHNVLDSKSVEV 693
Query: 171 EIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQ 230
E Q +E Q+ DQ+ + ++ + K +L + E H L + +
Sbjct: 694 ETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQLLSNE-------I 746
Query: 231 EEKQKCYNDLLAS--------AKKD-------------LEVERQTITQLSF--------- 260
+K +CY DL A KD L ++Q SF
Sbjct: 747 MDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANIIGEQGS 806
Query: 261 ---ELSEFRRKYEETQKEVHNLNQLLYSQRRADVQ-HLEDDRHKTEKIQKLREENDIARG 316
E SE R + +++ K N + R ++ LE + +QK EE +G
Sbjct: 807 MPSERSECRLEADQSPK-----NSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQIKG 861
Query: 317 KLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLD-FENEKLDRQHVQH 375
++EE ++E++ + + + +E T Q + A TL EN++ + Q +
Sbjct: 862 EIEENLMKAEQMHQSFVAETSQRISKLQEDTSA---HQNVVAETLSALENKEKELQLLND 918
Query: 376 QLHVILKELRKARNQITQLE-SLKQL 400
++ E+++ + LE SLK+L
Sbjct: 919 KVETEQAEIQELKKSNHLLEDSLKEL 944
Score = 50.8 bits (120), Expect = 3e-06
Identities = 89/429 (20%), Positives = 171/429 (39%), Gaps = 56/429 (13%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E L+K K ++ + KT +G +E RL+E LE K+K +++L K+ +
Sbjct: 45 EAALQKQKQKVENEKT--------EGTNLKRENQRLMEICESLEKTKQKISHELQVKESQ 96
Query: 84 IQRLRDQLKARYSTTALLEQ-LEETTREGERREQVLKAL--------------------- 121
+ QL + LEQ L+ E ER +Q ++
Sbjct: 97 VNFQEGQLNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPS 156
Query: 122 ----SEEKDVLKQQLSAATSRIAELESKTNTL---RLSQTVAPNCFNSSINNIHEMEIQL 174
+ + LK++ + LE++ L + SQT+ N H+ +
Sbjct: 157 QYYSGSKYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSV 216
Query: 175 KD-ALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEK 233
EK L + QR + A F E++ T + S Q K+ + +
Sbjct: 217 FSWQQEKTPSHLSSNSQRTPIRRDFSASYFSGEQEV-TPSRSTLQIGKRDANSSFFDNSS 275
Query: 234 QKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQH 293
D L + ++L R I +L L + E + +V+ +L +A V+
Sbjct: 276 SPHLLDQLKAQNQEL---RNKINELELRLQGHEK---EMKGQVNKFQELQLQLEKAKVEL 329
Query: 294 LEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSL-LKQQEEQTRVALL 352
+E K + + K R+E + ++ + L +++ L L ++Q ++ L
Sbjct: 330 IE----KEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSL 385
Query: 353 EQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQ-LESLKQLHEF--AITEPL 409
EQ+++ +F+ E+L RQ Q + +E + + ++TQ L+ K +H A + L
Sbjct: 386 EQKIKEKEKEFQ-EELSRQ--QRSFQTLDQECIQMKARLTQELQQAKNMHNVLQAELDKL 442
Query: 410 VTFQGETEN 418
+ + + EN
Sbjct: 443 TSVKQQLEN 451
Score = 48.9 bits (115), Expect = 1e-05
Identities = 97/459 (21%), Positives = 192/459 (41%), Gaps = 79/459 (17%)
Query: 7 KDLIKSKWGSKPSNSKSETTLEKLKGEI-AHLKTSVDEITSGKGKLTDKERHRLLEKIRV 65
++L+K++ + +++ + KL+ + AH + +++ + K +KE L +K+
Sbjct: 865 ENLMKAEQMHQSFVAETSQRISKLQEDTSAHQNVVAETLSALENK--EKELQLLNDKVET 922
Query: 66 LEAEKE---KNAYQLTEKDKEIQRLRDQL---KARYSTTALLE--QLEETTREGERREQV 117
+AE + K+ + L + KE+Q L + L K S+ L ++EE T+E +++
Sbjct: 923 EQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEI 982
Query: 118 LKALSEEKDVLKQQLSAATSRIAELESKTNTLR-----------------------LSQ- 153
+L++EK L Q+ + + I E E + L LSQ
Sbjct: 983 NASLNQEKMNLIQKSESFANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQK 1042
Query: 154 ------------TVAPNCFNSSINNIHEMEIQLKDALEKNQQ----WLVYDQQR------ 191
+ C + N +E+E QLK+A K Q L + ++R
Sbjct: 1043 YKAAQEKNSKLECLLNECTSLCENRKNELE-QLKEAFAKEHQEFLTKLAFAEERNQNLML 1101
Query: 192 --EVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
E + L +++ + + +++ A L Q+ + E Q + QK NDLL ++ ++
Sbjct: 1102 ELETVQQALRSEMTDNQNNSKSEAGGLKQEIMTLKEE---QNKMQKEVNDLLQENEQLMK 1158
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLRE 309
V + + E R +E + E + N Q +V+ + D + + +Q L
Sbjct: 1159 VMKTKHECQNLESEPIRNSVKERESERNQCN--FKPQMDLEVKEISLDSYNAQLVQ-LEA 1215
Query: 310 ENDIARGKLEEEKKRSEELLSQVQF----LYTSLLKQQEEQTRVALLEQQMQACTLDFEN 365
KL+E +K E L ++Q L TS L+ + Q L + C +D E
Sbjct: 1216 MLRNKELKLQESEKEKECLQHELQTIRGDLETSNLQDMQSQEISGLKD-----CEIDAEE 1270
Query: 366 EKLDRQH----VQHQLHVILKELRKARNQITQLESLKQL 400
+ + H Q+ + L+ N++ +LE + ++
Sbjct: 1271 KYISGPHELSTSQNDNAHLQCSLQTTMNKLNELEKICEI 1309
Score = 46.6 bits (109), Expect = 5e-05
Identities = 83/404 (20%), Positives = 169/404 (41%), Gaps = 55/404 (13%)
Query: 57 HRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLE-QLEETTREGERRE 115
H L +++ E + + + ++D++++ L +++K S L E QL E
Sbjct: 1770 HNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIELE 1829
Query: 116 QVLKALSEEKDVLKQQLSAATSRIAELESKTNTLR-LSQTVAPNCFNSSINNIHEMEIQL 174
+++ L +E L ++L + EL + T L+ + + SS +I +
Sbjct: 1830 KIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGD----- 1884
Query: 175 KDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYL----Q 230
+ + N W ++R + V+ L++I + E A L + ++E
Sbjct: 1885 -NVAKVNDSW----KERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKLCLEKDN 1939
Query: 231 EEKQK---CYNDLLA---SAKKDLEVERQTITQLSFELSEFRRKYEE------------- 271
E KQK C + L+ S + L E T+++ + L + K +E
Sbjct: 1940 ENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECL 1999
Query: 272 -----TQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREEN---DIARGKLEEE-- 321
+ EV +LL + + L+D H EK+Q L +++ + + +LE +
Sbjct: 2000 HCIQVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDSQALSLTKCELENQIA 2059
Query: 322 --KKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHV 379
K E L+ + + L L + E+ V+ + ++A ++ L Q ++H
Sbjct: 2060 QLNKEKELLVKESESLQARLSESDYEKLNVS---KALEAALVEKGEFALRLSSTQEEVHQ 2116
Query: 380 ILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETEN-REKV 422
+ + + K R +I + + KQLH I E L + E ++ ++KV
Sbjct: 2117 LRRGIEKLRVRI-EADEKKQLH---IAEKLKERERENDSLKDKV 2156
Score = 35.0 bits (79), Expect = 0.14
Identities = 48/248 (19%), Positives = 104/248 (41%), Gaps = 17/248 (6%)
Query: 155 VAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAH 214
+ P F + +IH +++++K+ +N + L + R+ V+ LL ++ EL+ K
Sbjct: 1757 LVPMDFLGNQEDIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLH---- 1812
Query: 215 SLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQK 274
L + + E ++ EK ++ KK+ + + S + E ++ E ++
Sbjct: 1813 -LQEVQLMTKIEACIELEK------IVGELKKENSDLSEKLEYFSCDHQELLQRVETSEG 1865
Query: 275 EVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIAR-----GKLEEEKKRSEELL 329
+L R D+ + + K + L EN+++R +E E E L
Sbjct: 1866 LNSDLEMHADKSSREDIGDNVAKVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADL 1925
Query: 330 SQVQFLYTSLLKQQEEQTRVAL-LEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKAR 388
VQ L K E + +V + LE+++ T + + + + + + + K +
Sbjct: 1926 EVVQTEKLCLEKDNENKQKVIVCLEEELSVVTSERNQLRGELDTMSKKTTALDQLSEKMK 1985
Query: 389 NQITQLES 396
+ +LES
Sbjct: 1986 EKTQELES 1993
Score = 33.1 bits (74), Expect = 0.55
Identities = 70/368 (19%), Positives = 133/368 (36%), Gaps = 61/368 (16%)
Query: 120 ALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALE 179
AL E K+ L + A +I ELE + + L+ + +S L+ AL+
Sbjct: 4 ALEEWKEGLPTR---ALQKIQELEGQLDKLKKEKQQRQFQLDS-----------LEAALQ 49
Query: 180 KNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYND 239
K +Q + ++ +K ++ E+ + E + + + ES+ QE +
Sbjct: 50 KQKQKVENEKTEGTNLKRENQRLMEICESLEKTKQKISHELQVKESQVNFQEGQ------ 103
Query: 240 LLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLN--QLLYSQRRADVQHLEDD 297
L S KK +E Q + + EL ++ + ++ N Q +++ Q+
Sbjct: 104 -LNSGKKQIEKLEQELKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGS 162
Query: 298 RHKT--EKIQKLREENDIARGKLEE-EKKRSEELLSQVQFLY---------TSLLKQQEE 345
+++ EK K EE +++ + K++ + L Q + +S+ Q+E
Sbjct: 163 KYEDLKEKYNKEVEERKRLEAEVKALQAKKASQTLPQATMNHRDIARHQASSSVFSWQQE 222
Query: 346 QT--------------------------RVALLEQQMQACTLDFENEKLDRQHVQHQLHV 379
+T V +Q D + D H L
Sbjct: 223 KTPSHLSSNSQRTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQ 282
Query: 380 ILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVE 439
+ + ++ RN+I +LE Q HE + + FQ EK LN+ E
Sbjct: 283 LKAQNQELRNKINELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDE 342
Query: 440 CPKCNIQY 447
+ QY
Sbjct: 343 LVRTTAQY 350
>gi|118498362 kinectin 1 isoform b [Homo sapiens]
Length = 1306
Score = 69.3 bits (168), Expect = 7e-12
Identities = 91/368 (24%), Positives = 165/368 (44%), Gaps = 51/368 (13%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K + E+++ EIAHLK + T++ + ++ L + + +LTEK
Sbjct: 407 KFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNKLRQDYARLVNELTEKT 466
Query: 82 KEIQRLRDQLK-ARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLS----AAT 136
++Q+ Q K A + T L QL+E R E + ++ + E + +Q L A
Sbjct: 467 GKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKE 526
Query: 137 SRIAELESK-TNTLRLSQTVAPNCF------NSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
+ + L SK T+TL Q + +N +++Q++D LE+N+ Q
Sbjct: 527 NEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQ 586
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
Q F + +T+A L ++ K +E ++++ K D LAS
Sbjct: 587 Q------------FHSQIAAQTSASVLAEELHKVIAE---KDKQIKQTEDSLAS------ 625
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRH----KTEKIQ 305
ER +T EL + + + EV L Q L +++ A LE + K +KI+
Sbjct: 626 -ERDRLTSKEEELKDIQNMNFLLKAEVQKL-QALANEQAAAAHELEKMQQSVYVKDDKIR 683
Query: 306 KLRE--ENDIARGKLEEEK---KRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACT 360
L E +++I+ K+EE K +++ L S+VQ L T + +Q + + +QM+ C
Sbjct: 684 LLEEQLQHEIS-NKMEEFKILNDQNKALKSEVQKLQTLVSEQPNKD-----VVEQMEKC- 736
Query: 361 LDFENEKL 368
+ ++EKL
Sbjct: 737 IQEKDEKL 744
Score = 57.0 bits (136), Expect = 4e-08
Identities = 86/424 (20%), Positives = 190/424 (44%), Gaps = 64/424 (15%)
Query: 30 LKGEIAHLKTSVDEITSGKGKLTDKERHRLL--EKIRVLEAEKEKNAYQLTEKDKEIQRL 87
LK E+ L+ +E + +L ++ + +KIR+LE E+ ++++ K +E + L
Sbjct: 647 LKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLE---EQLQHEISNKMEEFKIL 703
Query: 88 RDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLK---QQLSAATSRIAELES 144
DQ KA S L+ L + EQ+ K + E+ + LK + L ++A E
Sbjct: 704 NDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEE 763
Query: 145 KTNTLRLSQTVAPNCFNSSI-NNIHEMEIQLKD-----ALEKNQQWLVYDQQREV-YVKG 197
+ N +R NSS+ + +++ + D +L + + +++++ ++ V+
Sbjct: 764 ELNAIRTE--------NSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEE 815
Query: 198 LL-AKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTIT 256
LL A++ ++ K +T S+ + ++ ++ +EE+ +L +KDL + +
Sbjct: 816 LLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ 875
Query: 257 QLSFELSEFRRKYEETQKEVHNLN-----------QLLYSQRRADVQHLE--------DD 297
L E + +E + HNL +++ ++ +++ LE D
Sbjct: 876 DLQEENESLKAHVQEVAQ--HNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDL 933
Query: 298 RHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQ 357
KT+ +Q +++EN + + ++E+ L Q + S EE +V + E++ +
Sbjct: 934 SSKTQLLQDVQDENKLFKSQIEQ--------LKQQNYQQASSFPPHEELLKV-ISEREKE 984
Query: 358 ACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETE 417
L E + L + V+HQ RK N + + ++ + + A TE ++ +
Sbjct: 985 ISGLWNELDSL-KDAVEHQ--------RKKNNDLRE-KNWEAMEALASTEKMLQDKVNKT 1034
Query: 418 NREK 421
++E+
Sbjct: 1035 SKER 1038
Score = 55.5 bits (132), Expect = 1e-07
Identities = 104/476 (21%), Positives = 196/476 (41%), Gaps = 91/476 (19%)
Query: 15 GSKPSNSKSETTLEKLKGEIAH----LKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEK 70
G + + + LE+ + ++A+ L+ +E S K + + +H L E + E+
Sbjct: 848 GKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEE 907
Query: 71 EKNAYQLTEKDKEIQRLRDQLKARYST----TALLE-----------QLEETTREGERR- 114
+ L EK+ E++RL LK R S T LL+ Q+E+ ++ ++
Sbjct: 908 LEIV--LKEKENELKRLEAMLKERESDLSSKTQLLQDVQDENKLFKSQIEQLKQQNYQQA 965
Query: 115 ------EQVLKALSE-EKDV--LKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSIN 165
E++LK +SE EK++ L +L + + K N LR A S+
Sbjct: 966 SSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEK 1025
Query: 166 NIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKI--------------FELEKKTET 211
+ + K + E+ QQ + + + +K L K+ FE + K
Sbjct: 1026 MLQDKVN--KTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLSYGEWLHGFEKKAKECM 1083
Query: 212 AAHSLPQQTK--------KPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELS 263
A S ++ K E LQ E +K Y +LA + L+ ++++ Q E +
Sbjct: 1084 AGTSGSEEVKVLEHKLKEADEMHTLLQLECEK-YKSVLAETEGILQKLQRSVEQ---EEN 1139
Query: 264 EFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKK 323
+++ K +E+ K + + S Q LE R + + I+ LR E R LE E +
Sbjct: 1140 KWKVKVDESHKTIKQMQSSFTSSE----QELERLRSENKDIENLRRE----REHLEMELE 1191
Query: 324 RSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKE 383
++E +++ T V L+ Q+ E+ +RQ V LH +
Sbjct: 1192 KAE-------------MERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLHKAQQS 1238
Query: 384 LRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVE 439
L +++I + + E + P ETE+ EK ++ + +LN+++ +
Sbjct: 1239 LELIQSKIVKAAGDTTVIENSDVSP------ETESSEK-----ETMSVSLNQTVTQ 1283
Score = 32.3 bits (72), Expect = 0.94
Identities = 37/179 (20%), Positives = 76/179 (42%), Gaps = 20/179 (11%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKD 81
K ++ L + +G + L+ SV++ K K+ E H+ +++++ E+ +L ++
Sbjct: 1115 KYKSVLAETEGILQKLQRSVEQ-EENKWKVKVDESHKTIKQMQSSFTSSEQELERLRSEN 1173
Query: 82 KEIQRLR-------------DQLKARYSTTA--LLEQLEETTREGERREQVLKALSEEKD 126
K+I+ LR + ++ Y T L QL ET + + + ++ +
Sbjct: 1174 KDIENLRREREHLEMELEKAEMERSTYVTEVRELKAQLNETLTKLRTEQNERQKVAGDLH 1233
Query: 127 VLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWL 185
+Q L S+I + T + S V+P +S M + L + + QQ L
Sbjct: 1234 KAQQSLELIQSKIVKAAGDTTVIENSD-VSPETESSEKET---MSVSLNQTVTQLQQLL 1288
>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
sapiens]
Length = 1843
Score = 69.3 bits (168), Expect = 7e-12
Identities = 94/413 (22%), Positives = 179/413 (43%), Gaps = 38/413 (9%)
Query: 6 TKDLIKSKWGSKPS----NSKSETTLEKLKGEIAHLKTSVDEIT-----SGKGKLTD--K 54
+KDL+K K + + SE ++ L+ E HL +V + S + ++ D K
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 55 ERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERR 114
E L E I+ ++ K ++ + KE++ +++ + L LE+ +++
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 115 EQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQL 174
LK E+ + L+Q+ S +L+ ++ + + T + + E ++L
Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDEENLEL 706
Query: 175 KDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQ 234
+ +E + + Q ++ K L ++ +L+K E S + + S L E Q
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 235 KCYNDLLASAKK---------DLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYS 285
+ L S KK DLE+E QT+ + EL ++ E+ +KE +L Q S
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET-S 825
Query: 286 QRRADVQHLEDDRHKTEKIQKLR----EENDIARGKLEEEKKRSEELLSQVQFLYTS--- 338
Q D + LE + + + +++ EEN++ G LE+E K LS+ +Y
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK----TLSKEIGIYKESCV 881
Query: 339 LLKQQEEQTRVALLEQQMQACTL-----DFENEKLDRQHVQHQLHVILKELRK 386
LK+ E++ + + + TL D +EKL Q + + L + EL K
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Score = 58.9 bits (141), Expect = 9e-09
Identities = 98/451 (21%), Positives = 192/451 (42%), Gaps = 61/451 (13%)
Query: 23 SETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDK 82
S LE+L+ E L+ ++ K +L +KE RL ++ + + E+N ++ +K
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQL-EKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
Query: 83 EIQRLRDQLKARYSTTALLEQLEETTREGERREQV----LKALSEE---KDVLKQQLSAA 135
E + L ++ + L++LE+ +E +R + L L E+ + + QQ++
Sbjct: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
Query: 136 TSRIA-ELE----SKTNTLRLSQTVAPNCF---NSSINNIHEMEIQLKD----ALE-KNQ 182
++ ELE +K L Q+ + + S + + + +++K+ ALE + +
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLE 984
Query: 183 QWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLA 242
+ Y+QQ +K + K +E K+ + + + + E Q+ +LL
Sbjct: 985 ESTNYNQQLRQELK-TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLK 1043
Query: 243 SAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTE 302
+ +EVER T L E + + ++ + + +NL + + +R V E +
Sbjct: 1044 VKDRLIEVERNNAT-LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQT 1102
Query: 303 KIQKLREEND-----------------IARGKLEEEKKRSEELLSQVQFLYTSLLKQQEE 345
+ KL+ EN I + LE E + + ++ LY SL+K E
Sbjct: 1103 QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE- 1161
Query: 346 QTRVALLEQQMQACTLDFENEKLDRQH-----VQHQLHVILKELRKARNQIT----QLES 396
++ LL ++ + E E L +H L V ++L NQ+ QLE
Sbjct: 1162 --KLELLHERQAS-----EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLED 1214
Query: 397 LKQLHEFAITEPLVTFQGETENREKVAASPK 427
L+++ + + L+ E +N E VAA K
Sbjct: 1215 LEKMLKVEQEKMLL----ENKNHETVAAEYK 1241
Score = 58.9 bits (141), Expect = 9e-09
Identities = 100/445 (22%), Positives = 196/445 (44%), Gaps = 73/445 (16%)
Query: 7 KDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLE----- 61
+DL+ K ++ N+ LEKL E+ + + + + + + TD R++LLE
Sbjct: 909 EDLVSEKLKTQQMNND----LEKLTHELEKIGLNKERLLHDE-QSTDDSRYKLLESKLES 963
Query: 62 -----------KIRVLEAEKEKNA---YQLTEKDKEIQRLRDQLKARYSTTALLE----- 102
KI LEA E++ QL ++ K +++ + LK R +++
Sbjct: 964 TLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPI 1023
Query: 103 ---------QLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLS- 152
+ +ETTRE + + L + L+ + A +++ +LE++ N L+
Sbjct: 1024 SGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQI 1083
Query: 153 -----QTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVK--GLLAKIFEL 205
QTV+ N+++ ++Q++++ +Q + +Q ++ ++ L + +
Sbjct: 1084 LALQRQTVSLQEQNTTLQT-QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESV 1142
Query: 206 EKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLA------SAKKDLEVERQTITQLS 259
K+ E K E L E + Y L++ SA K+LEVE + +
Sbjct: 1143 IKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRY 1202
Query: 260 FELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKT--EKIQKLREENDIARGK 317
+L + + + E+ +K L Q + LE+ H+T + +KL END
Sbjct: 1203 NQLLKQKGQLEDLEK------MLKVEQEK---MLLENKNHETVAAEYKKLCGENDRLNHT 1253
Query: 318 LEEEKKRSEELLSQVQFLYTSLLKQQEEQTRV----ALLEQQMQACTLDFENEKLDRQ-H 372
+ K +E L + + L + L + EQTR+ + L++Q Q LD + KL+ Q
Sbjct: 1254 YSQLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQ--QLDITSTKLNNQCE 1311
Query: 373 VQHQLHVILKELRKARNQITQLESL 397
+ QL L+E + R+ + Q+++L
Sbjct: 1312 LLSQLKGNLEE--ENRHLLDQIQTL 1334
Score = 49.7 bits (117), Expect = 6e-06
Identities = 96/439 (21%), Positives = 181/439 (41%), Gaps = 88/439 (20%)
Query: 21 SKSETTLEK---LKGE-IAHLKTSVDEITSGKGKLTDK---------------ERHRLLE 61
SK E+TL+K +K E IA L+ ++E T+ +L + + R+++
Sbjct: 959 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1018
Query: 62 KIRVLEAEKEKNAYQLTEKDKEIQRLRDQL--------KARYSTTALLEQLEETTREGER 113
+ E K + E +E+ +++D+L + AL QL++ +
Sbjct: 1019 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1078
Query: 114 REQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPN------CFNSSINNI 167
+ + AL + L++Q + ++ A+L+ + +TL T N SS+ N
Sbjct: 1079 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1138
Query: 168 HEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFEL---EKKTETAAHSLPQQTKKPE 224
+E I+ ++ L+ L+ D ++ + A +E + T +AH + +
Sbjct: 1139 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL 1198
Query: 225 SEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFEL--SEFRRKYEETQKEVHNLNQL 282
+ Y Q KQK + L K +E E+ + + E +E+++ E + H +QL
Sbjct: 1199 EDRYNQLLKQKGQLEDLEKMLK-VEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1257
Query: 283 LYSQRRADVQH-----------LEDDRHKTE--KIQKLREENDIA--------------R 315
L H LE R + E K+++ ++ DI +
Sbjct: 1258 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1317
Query: 316 GKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQH 375
G LEEE + LL Q+Q T +L+ + LLEQ M E D HV+
Sbjct: 1318 GNLEEENR---HLLDQIQ---TLMLQNR------TLLEQNM---------ESKDLFHVEQ 1356
Query: 376 QLHV-ILKELRKARNQITQ 393
+ ++ L ELR+ + ++ +
Sbjct: 1357 RQYIDKLNELRRQKEKLEE 1375
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/432 (18%), Positives = 175/432 (40%), Gaps = 73/432 (16%)
Query: 34 IAHLKTSVDEITSGKG-KLTDKERHRLLE------KIRVLEAEKEKNAYQLTEKDKEIQR 86
+ H +S G K T+ +H +E KIR L E E+ QL + +E+++
Sbjct: 224 LPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQ 283
Query: 87 LRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELES-- 144
+ +LK L + R L+ + D L+ ++S R+ ++E
Sbjct: 284 MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYK 343
Query: 145 --------------KTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQ 190
+T T+ Q + ++ + + +QLK L + D++
Sbjct: 344 ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK 403
Query: 191 REVYVKGLLAKIFELE---KKTETAAHSLPQQTKKPESEGYLQEEKQKCY----NDLLAS 243
+ ++ L+ + LE K++ + L + ++ L E QK N+L +S
Sbjct: 404 K---IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 244 AKKDLEVERQTITQLSFELS--------------EFRRKYEETQKEVHNLNQLLYSQRRA 289
LE+E Q++T+ EL + ++ + K+V L + ++++
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 290 --DVQHLEDDRHKTEK-----IQKLREENDIARGKLEEEKKRSEELLSQV----QFLYTS 338
+ Q+L D K + I+ LRE ++ LE+E + + +S + Q +
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 339 LLKQQEEQTRV---ALLEQQMQACTLDFENEKLDR------------QHVQHQLHVILKE 383
+K E++ ++ ++ E + ++FE ++ + + ++++LH + KE
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 384 LRKARNQITQLE 395
+ +IT L+
Sbjct: 641 NELLQKKITNLK 652
Score = 39.3 bits (90), Expect = 0.008
Identities = 52/243 (21%), Positives = 107/243 (44%), Gaps = 29/243 (11%)
Query: 204 ELEKKTETAAHSLPQQTKKPESE-GYLQEEKQKCYNDLLASA--KKDLEVERQT---ITQ 257
ELE+KTE Q+ ++ E E LQ+E +D ++ + +L+ R+ + +
Sbjct: 266 ELEEKTEQLL-DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324
Query: 258 LSFELSEFRRK------YEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREEN 311
L E+S ++ + Y+ +E+ NQ+L + LE R +++K+ +L +EN
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
Query: 312 DIARGKLEE-------EKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFE 364
+ KL + ++K+ EEL+ + L + + +E L +++ + E
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLH---LGWELEQISRTSE 441
Query: 365 NEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAA 424
+ ++ + H+++ EL +R + +LE Q + E T N K+
Sbjct: 442 LSEAPQKSLGHEVN----ELTSSR--LLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495
Query: 425 SPK 427
K
Sbjct: 496 MEK 498
>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
sapiens]
Length = 1870
Score = 69.3 bits (168), Expect = 7e-12
Identities = 94/413 (22%), Positives = 179/413 (43%), Gaps = 38/413 (9%)
Query: 6 TKDLIKSKWGSKPS----NSKSETTLEKLKGEIAHLKTSVDEIT-----SGKGKLTD--K 54
+KDL+K K + + SE ++ L+ E HL +V + S + ++ D K
Sbjct: 528 SKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEK 587
Query: 55 ERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERR 114
E L E I+ ++ K ++ + KE++ +++ + L LE+ +++
Sbjct: 588 ENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKENELLQKK 647
Query: 115 EQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQL 174
LK E+ + L+Q+ S +L+ ++ + + T + + E ++L
Sbjct: 648 ITNLKITCEKIEALEQENSELERENRKLKKTLDSFK-NLTFQLESLEKENSQLDEENLEL 706
Query: 175 KDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQ 234
+ +E + + Q ++ K L ++ +L+K E S + + S L E Q
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELLKASFKKTERLEVSYQGLDIENQ 766
Query: 235 KCYNDLLASAKK---------DLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYS 285
+ L S KK DLE+E QT+ + EL ++ E+ +KE +L Q S
Sbjct: 767 RLQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQET-S 825
Query: 286 QRRADVQHLEDDRHKTEKIQKLR----EENDIARGKLEEEKKRSEELLSQVQFLYTS--- 338
Q D + LE + + + +++ EEN++ G LE+E K LS+ +Y
Sbjct: 826 QLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENK----TLSKEIGIYKESCV 881
Query: 339 LLKQQEEQTRVALLEQQMQACTL-----DFENEKLDRQHVQHQLHVILKELRK 386
LK+ E++ + + + TL D +EKL Q + + L + EL K
Sbjct: 882 RLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEK 934
Score = 59.7 bits (143), Expect = 5e-09
Identities = 93/450 (20%), Positives = 185/450 (41%), Gaps = 60/450 (13%)
Query: 23 SETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDK 82
S LE+L+ E L+ ++ K +L +KE RL ++ + + E+N ++ +K
Sbjct: 806 SSKRLEQLEKENKSLEQETSQLEKDKKQL-EKENKRLRQQAEIKDTTLEENNVKIGNLEK 864
Query: 83 EIQRLRDQLKARYSTTALLEQLEETTREGERREQV----LKALSEEKDVLKQQLSAATSR 138
E + L ++ + L++LE+ +E +R + L L E+ K + +
Sbjct: 865 ENKTLSKEIGIYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNND 924
Query: 139 IAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKN---------------QQ 183
+ +L + + L++ + S+ + +E +L+ L+K+ ++
Sbjct: 925 LEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIAALEARLEE 984
Query: 184 WLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLAS 243
Y+QQ +K + K +E K+ + + + + E Q+ +LL
Sbjct: 985 STNYNQQLRQELK-TVKKNYEALKQRQDEERMVQSSPPISGEDNKWERESQETTRELLKV 1043
Query: 244 AKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEK 303
+ +EVER T L E + + ++ + + +NL + + +R V E + +
Sbjct: 1044 KDRLIEVERNNAT-LQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQ 1102
Query: 304 IQKLREEND-----------------IARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQ 346
KL+ EN I + LE E + + ++ LY SL+K E
Sbjct: 1103 NAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHE-- 1160
Query: 347 TRVALLEQQMQACTLDFENEKLDRQH-----VQHQLHVILKELRKARNQIT----QLESL 397
++ LL ++ + E E L +H L V ++L NQ+ QLE L
Sbjct: 1161 -KLELLHERQAS-----EYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDL 1214
Query: 398 KQLHEFAITEPLVTFQGETENREKVAASPK 427
+++ + + L+ E +N E VAA K
Sbjct: 1215 EKMLKVEQEKMLL----ENKNHETVAAEYK 1240
Score = 57.0 bits (136), Expect = 4e-08
Identities = 101/439 (23%), Positives = 196/439 (44%), Gaps = 62/439 (14%)
Query: 7 KDLIKSKWGSKPSNSKSETT---LEKL---KGEIAHLKTSVDE---ITSGKGKLTDKERH 57
+DL+ K ++ N+ E LEK+ K + H + S D+ + K + T K+
Sbjct: 909 EDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSL 968
Query: 58 RLLE-KIRVLEAEKEKNA---YQLTEKDKEIQRLRDQLKARYSTTALLE----------- 102
+ E KI LEA E++ QL ++ K +++ + LK R +++
Sbjct: 969 EIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQSSPPISGEDNK 1028
Query: 103 ---QLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLS------Q 153
+ +ETTRE + + L + L+ + A +++ +LE++ N L+ Q
Sbjct: 1029 WERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQ 1088
Query: 154 TVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVK--GLLAKIFELEKKTET 211
TV+ N+++ ++Q++++ +Q + +Q ++ ++ L + + K+ E
Sbjct: 1089 TVSLQEQNTTLQT-QNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESVIKERED 1147
Query: 212 AAHSLPQQTKKPESEGYLQEEKQKCYNDLLA------SAKKDLEVERQTITQLSFELSEF 265
K E L E + Y L++ SA K+LEVE + + +L +
Sbjct: 1148 LKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQ 1207
Query: 266 RRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKT--EKIQKLREENDIARGKLEEEKK 323
+ + E+ +K L Q + LE+ H+T + +KL END + K
Sbjct: 1208 KGQLEDLEK------MLKVEQEK---MLLENKNHETVAAEYKKLCGENDRLNHTYSQLLK 1258
Query: 324 RSEELLSQVQFLYTSLLKQQEEQTRV----ALLEQQMQACTLDFENEKLDRQ-HVQHQLH 378
+E L + + L + L + EQTR+ + L++Q Q LD + KL+ Q + QL
Sbjct: 1259 ETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQ--QLDITSTKLNNQCELLSQLK 1316
Query: 379 VILKELRKARNQITQLESL 397
L+E + R+ + Q+++L
Sbjct: 1317 GNLEE--ENRHLLDQIQTL 1333
Score = 49.7 bits (117), Expect = 6e-06
Identities = 96/439 (21%), Positives = 181/439 (41%), Gaps = 88/439 (20%)
Query: 21 SKSETTLEK---LKGE-IAHLKTSVDEITSGKGKLTDK---------------ERHRLLE 61
SK E+TL+K +K E IA L+ ++E T+ +L + + R+++
Sbjct: 958 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1017
Query: 62 KIRVLEAEKEKNAYQLTEKDKEIQRLRDQL--------KARYSTTALLEQLEETTREGER 113
+ E K + E +E+ +++D+L + AL QL++ +
Sbjct: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNN 1077
Query: 114 REQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPN------CFNSSINNI 167
+ + AL + L++Q + ++ A+L+ + +TL T N SS+ N
Sbjct: 1078 LQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENE 1137
Query: 168 HEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFEL---EKKTETAAHSLPQQTKKPE 224
+E I+ ++ L+ L+ D ++ + A +E + T +AH + +
Sbjct: 1138 NESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRDL 1197
Query: 225 SEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFEL--SEFRRKYEETQKEVHNLNQL 282
+ Y Q KQK + L K +E E+ + + E +E+++ E + H +QL
Sbjct: 1198 EDRYNQLLKQKGQLEDLEKMLK-VEQEKMLLENKNHETVAAEYKKLCGENDRLNHTYSQL 1256
Query: 283 LYSQRRADVQH-----------LEDDRHKTE--KIQKLREENDIA--------------R 315
L H LE R + E K+++ ++ DI +
Sbjct: 1257 LKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLK 1316
Query: 316 GKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQH 375
G LEEE + LL Q+Q T +L+ + LLEQ M E D HV+
Sbjct: 1317 GNLEEENR---HLLDQIQ---TLMLQNR------TLLEQNM---------ESKDLFHVEQ 1355
Query: 376 QLHV-ILKELRKARNQITQ 393
+ ++ L ELR+ + ++ +
Sbjct: 1356 RQYIDKLNELRRQKEKLEE 1374
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/432 (18%), Positives = 175/432 (40%), Gaps = 73/432 (16%)
Query: 34 IAHLKTSVDEITSGKG-KLTDKERHRLLE------KIRVLEAEKEKNAYQLTEKDKEIQR 86
+ H +S G K T+ +H +E KIR L E E+ QL + +E+++
Sbjct: 224 LPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQ 283
Query: 87 LRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELES-- 144
+ +LK L + R L+ + D L+ ++S R+ ++E
Sbjct: 284 MEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEFYK 343
Query: 145 --------------KTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQ 190
+T T+ Q + ++ + + +QLK L + D++
Sbjct: 344 ARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRK 403
Query: 191 REVYVKGLLAKIFELE---KKTETAAHSLPQQTKKPESEGYLQEEKQKCY----NDLLAS 243
+ ++ L+ + LE K++ + L + ++ L E QK N+L +S
Sbjct: 404 K---IEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS 460
Query: 244 AKKDLEVERQTITQLSFELS--------------EFRRKYEETQKEVHNLNQLLYSQRRA 289
LE+E Q++T+ EL + ++ + K+V L + ++++
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520
Query: 290 --DVQHLEDDRHKTEK-----IQKLREENDIARGKLEEEKKRSEELLSQV----QFLYTS 338
+ Q+L D K + I+ LRE ++ LE+E + + +S + Q +
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580
Query: 339 LLKQQEEQTRV---ALLEQQMQACTLDFENEKLDR------------QHVQHQLHVILKE 383
+K E++ ++ ++ E + ++FE ++ + + ++++LH + KE
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640
Query: 384 LRKARNQITQLE 395
+ +IT L+
Sbjct: 641 NELLQKKITNLK 652
Score = 39.3 bits (90), Expect = 0.008
Identities = 52/243 (21%), Positives = 107/243 (44%), Gaps = 29/243 (11%)
Query: 204 ELEKKTETAAHSLPQQTKKPESE-GYLQEEKQKCYNDLLASA--KKDLEVERQT---ITQ 257
ELE+KTE Q+ ++ E E LQ+E +D ++ + +L+ R+ + +
Sbjct: 266 ELEEKTEQLL-DCKQELEQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDK 324
Query: 258 LSFELSEFRRK------YEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREEN 311
L E+S ++ + Y+ +E+ NQ+L + LE R +++K+ +L +EN
Sbjct: 325 LESEVSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKEN 384
Query: 312 DIARGKLEE-------EKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFE 364
+ KL + ++K+ EEL+ + L + + +E L +++ + E
Sbjct: 385 LQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLH---LGWELEQISRTSE 441
Query: 365 NEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAA 424
+ ++ + H+++ EL +R + +LE Q + E T N K+
Sbjct: 442 LSEAPQKSLGHEVN----ELTSSR--LLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495
Query: 425 SPK 427
K
Sbjct: 496 MEK 498
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 69.3 bits (168), Expect = 7e-12
Identities = 95/435 (21%), Positives = 182/435 (41%), Gaps = 73/435 (16%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E T + LK E+ L +S D++ K H L + R LE + E+ QL E + E
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDV--------GKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 84 IQRLRD-QLKARYSTTALLEQLEETTR-----EGERREQVLKAL----SEEKDVLKQQLS 133
+Q D +L+ + AL Q E + E+R Q+ + L +E +D KQ+
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 134 AATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKD-------ALEKNQQWLV 186
AA ++ +LE L L A +I + +++ Q+KD A +
Sbjct: 1615 AAAAK-KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 187 YDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPES-----------EGYLQEEKQK 235
++ E K L A + +L++ A + Q + E LQ+EK++
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 236 CYNDLLASAKKDLEVER--------------QTITQLSFELS--------------EFRR 267
+A +++LE E+ Q QLS EL+ + R
Sbjct: 1734 L-EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 268 KYEETQKEVHNLNQLLYSQRRADVQHLEDD-RHKTEKIQKLREENDIARGKLEEEKKRSE 326
+ +E + ++H + + S+ ++ + LE E++++ E A L+++ K+ +
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 327 ELLSQVQFLYTSLLKQQEEQ-----TRVALLEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
E+L QV+ + +Q +EQ RV L++Q++ + + +R+ +Q +L
Sbjct: 1853 EILLQVED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 382 KELRKARNQITQLES 396
+ ++ L+S
Sbjct: 1912 ESNEAMGREVNALKS 1926
Score = 68.2 bits (165), Expect = 2e-11
Identities = 101/410 (24%), Positives = 171/410 (41%), Gaps = 51/410 (12%)
Query: 16 SKPSNSKSETTLEK----LKGEIAHLKTSVDEITSGKGKL-----------TDKERHR-- 58
+K + K++ TLEK L GE+ L + E+ K KL +D ER R
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 59 LLEKIRVLEAEKEKNAYQLTEKD-KEIQRLRDQLKARYSTTALLEQLEETTREGERREQV 117
L +K+ L+ E E L E + K I+ +D E L+E TR+
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 118 LKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAP---NCFNSSINNIHEMEIQL 174
L+ L EE++ L+ QL LE +TL + + + F S++ + E + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 175 KDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYL---QE 231
+ +E Q Y+++ Y K LEK L +++ L E
Sbjct: 1398 QKEIENLTQ--QYEEKAAAYDK--------LEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1447
Query: 232 EKQKCYNDLLASAKK----------DLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQ 281
+KQ+ ++ LLA K E E + + L+ + E ++E+ N+
Sbjct: 1448 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 282 LLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLK 341
+L ++ D+ +DD K + +L + ++EE K + EEL ++Q + L+
Sbjct: 1508 MLKAEME-DLVSSKDDVGK--NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 342 -QQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQ 390
+ Q E+ +QA D +NE+ RQ +Q QLH EL R Q
Sbjct: 1565 LEVNMQALKGQFERDLQA--RDEQNEEKRRQ-LQRQLHEYETELEDERKQ 1611
Score = 67.4 bits (163), Expect = 3e-11
Identities = 84/390 (21%), Positives = 161/390 (41%), Gaps = 39/390 (10%)
Query: 70 KEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLK 129
K K Q+T +++E+Q D+L+ E+ ++ E + EQ L+EEK++L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTK------ERQQKAENELKELEQKHSQLTEEKNLLQ 893
Query: 130 QQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
+QL A T AE E L + +HEME +L++ ++ QQ
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEI-------LHEMEARLEEEEDRGQQ---LQA 943
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
+R+ + +L +LE++ E A L + E++ E++ +D K+ +
Sbjct: 944 ERKKMAQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLRE 309
+ + I+ L+ L+E K + K + N ++ + S+ ++ E R + EK+++ E
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 310 -------------ENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQM 356
+ IA K++ KK EEL + + L + ++ ++ LE +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKK-EEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 357 QACTLDFENEKLDRQHVQHQ-------LHVILKELRKARNQITQLESLKQLHEFAITEPL 409
D ++E+ R + Q L + EL + + L+ E +T
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 410 VTFQGETENREKVAASPKSPTAALNESLVE 439
ET + E + A E L E
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Score = 64.7 bits (156), Expect = 2e-10
Identities = 113/471 (23%), Positives = 198/471 (42%), Gaps = 82/471 (17%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEIT--SGKGKLTDKERHRLLEKIRVL------EAEKEK 72
++ + LEK+ E A +K DEI + KER L E+I L E EK K
Sbjct: 965 ARQKLQLEKVTAE-AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 73 NAYQLTEKDKEI-----QRLRDQLKARYSTTALLEQLE------------------ETTR 109
N +L K + + RL+ + K+R L +LE E
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 110 EGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRL---SQTVAPNCFNSSINN 166
+ ++E+ L+A D Q + A +I ELE + L+ S+ A N +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 167 IHE----MEIQLKDALEK--NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQT 220
+ E ++ +L+D L+ QQ L +++EV V L K + ET +H Q
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTV---LKKALD----EETRSHEAQVQE 1196
Query: 221 KKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLN 280
+ + ++E ++ + AK +L+ +QT+ + + +L+ R + ++EV +
Sbjct: 1197 MRQKHAQAVEELTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 281 QLLYSQRRADVQHLED-----DRHKTE---KIQKLREENDIARGKLEEEKKRSEELLSQV 332
+ L A VQ L+ +R + E K+ KL+ E + G L E + ++ +L V
Sbjct: 1255 KKL----EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 333 QFLYTSLLKQQE---EQTRVAL--------LEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
L + L QE E+TR L LE++ + + E +Q+++ + +
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 382 KELRKARNQITQLESLKQLHEFAITEPLVTFQGETEN-----REKVAASPK 427
+L ++ ++ S + A+ E FQ E EN EK AA K
Sbjct: 1371 IQLSDSKKKLQDFASTVE----ALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Score = 47.0 bits (110), Expect = 4e-05
Identities = 99/418 (23%), Positives = 178/418 (42%), Gaps = 71/418 (16%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E L+K K + + E+ +LT+ E++ L E+ L+AE E A E
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQ---LQAETELYA--------E 905
Query: 84 IQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIA--- 140
+ +R +L A+ ++LEE E E R L EE+D QQL A ++A
Sbjct: 906 AEEMRVRLAAKK------QELEEILHEMEAR------LEEEED-RGQQLQAERKKMAQQM 952
Query: 141 --------ELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWL---VYDQ 189
E E+ L+L + A + I M+ Q + L K ++ L + D
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDL 1011
Query: 190 QREVYVKGLLAK-IFELEKKTETAAHSLPQQTKKPE-SEGYLQEEKQKCYNDLLASAKKD 247
+ + AK + +L+ K E+ L + KK E S L++ K+K D ++
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 248 LEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKL 307
+++ Q I +L +L+ +K EE Q + L+ + + A L+ R I L
Sbjct: 1072 ADLQAQ-IAELKMQLA---KKEEELQAALARLDDEIAQKNNA----LKKIRELEGHISDL 1123
Query: 308 REENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEK 367
+E+ D R + +K+ +L +++ L T L E+ +Q+++A
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTEL----EDTLDSTATQQELRA--------- 1170
Query: 368 LDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAI---TEPLVTFQGETENREK 421
+ ++ V+ K L + R+ Q++ ++Q H A+ TE L F+ N +K
Sbjct: 1171 ----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 69.3 bits (168), Expect = 7e-12
Identities = 95/435 (21%), Positives = 182/435 (41%), Gaps = 73/435 (16%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E T + LK E+ L +S D++ K H L + R LE + E+ QL E + E
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDV--------GKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 84 IQRLRD-QLKARYSTTALLEQLEETTR-----EGERREQVLKAL----SEEKDVLKQQLS 133
+Q D +L+ + AL Q E + E+R Q+ + L +E +D KQ+
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 134 AATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKD-------ALEKNQQWLV 186
AA ++ +LE L L A +I + +++ Q+KD A +
Sbjct: 1622 AAAAK-KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 187 YDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPES-----------EGYLQEEKQK 235
++ E K L A + +L++ A + Q + E LQ+EK++
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 236 CYNDLLASAKKDLEVER--------------QTITQLSFELS--------------EFRR 267
+A +++LE E+ Q QLS EL+ + R
Sbjct: 1741 L-EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 268 KYEETQKEVHNLNQLLYSQRRADVQHLEDD-RHKTEKIQKLREENDIARGKLEEEKKRSE 326
+ +E + ++H + + S+ ++ + LE E++++ E A L+++ K+ +
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 327 ELLSQVQFLYTSLLKQQEEQ-----TRVALLEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
E+L QV+ + +Q +EQ RV L++Q++ + + +R+ +Q +L
Sbjct: 1860 EILLQVED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918
Query: 382 KELRKARNQITQLES 396
+ ++ L+S
Sbjct: 1919 ESNEAMGREVNALKS 1933
Score = 68.2 bits (165), Expect = 2e-11
Identities = 101/410 (24%), Positives = 171/410 (41%), Gaps = 51/410 (12%)
Query: 16 SKPSNSKSETTLEK----LKGEIAHLKTSVDEITSGKGKL-----------TDKERHR-- 58
+K + K++ TLEK L GE+ L + E+ K KL +D ER R
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 59 LLEKIRVLEAEKEKNAYQLTEKD-KEIQRLRDQLKARYSTTALLEQLEETTREGERREQV 117
L +K+ L+ E E L E + K I+ +D E L+E TR+
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 118 LKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAP---NCFNSSINNIHEMEIQL 174
L+ L EE++ L+ QL LE +TL + + + F S++ + E + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 175 KDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYL---QE 231
+ +E Q Y+++ Y K LEK L +++ L E
Sbjct: 1405 QKEIENLTQ--QYEEKAAAYDK--------LEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454
Query: 232 EKQKCYNDLLASAKK----------DLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQ 281
+KQ+ ++ LLA K E E + + L+ + E ++E+ N+
Sbjct: 1455 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 282 LLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLK 341
+L ++ D+ +DD K + +L + ++EE K + EEL ++Q + L+
Sbjct: 1515 MLKAEME-DLVSSKDDVGK--NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 342 -QQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQ 390
+ Q E+ +QA D +NE+ RQ +Q QLH EL R Q
Sbjct: 1572 LEVNMQALKGQFERDLQA--RDEQNEEKRRQ-LQRQLHEYETELEDERKQ 1618
Score = 67.4 bits (163), Expect = 3e-11
Identities = 84/390 (21%), Positives = 161/390 (41%), Gaps = 39/390 (10%)
Query: 70 KEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLK 129
K K Q+T +++E+Q D+L+ E+ ++ E + EQ L+EEK++L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTK------ERQQKAENELKELEQKHSQLTEEKNLLQ 900
Query: 130 QQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
+QL A T AE E L + +HEME +L++ ++ QQ
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEI-------LHEMEARLEEEEDRGQQ---LQA 950
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
+R+ + +L +LE++ E A L + E++ E++ +D K+ +
Sbjct: 951 ERKKMAQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLRE 309
+ + I+ L+ L+E K + K + N ++ + S+ ++ E R + EK+++ E
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 310 -------------ENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQM 356
+ IA K++ KK EEL + + L + ++ ++ LE +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKK-EEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 357 QACTLDFENEKLDRQHVQHQ-------LHVILKELRKARNQITQLESLKQLHEFAITEPL 409
D ++E+ R + Q L + EL + + L+ E +T
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 410 VTFQGETENREKVAASPKSPTAALNESLVE 439
ET + E + A E L E
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Score = 64.7 bits (156), Expect = 2e-10
Identities = 113/471 (23%), Positives = 198/471 (42%), Gaps = 82/471 (17%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEIT--SGKGKLTDKERHRLLEKIRVL------EAEKEK 72
++ + LEK+ E A +K DEI + KER L E+I L E EK K
Sbjct: 972 ARQKLQLEKVTAE-AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 73 NAYQLTEKDKEI-----QRLRDQLKARYSTTALLEQLE------------------ETTR 109
N +L K + + RL+ + K+R L +LE E
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 110 EGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRL---SQTVAPNCFNSSINN 166
+ ++E+ L+A D Q + A +I ELE + L+ S+ A N +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 167 IHE----MEIQLKDALEK--NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQT 220
+ E ++ +L+D L+ QQ L +++EV V L K + ET +H Q
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTV---LKKALD----EETRSHEAQVQE 1203
Query: 221 KKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLN 280
+ + ++E ++ + AK +L+ +QT+ + + +L+ R + ++EV +
Sbjct: 1204 MRQKHAQAVEELTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 281 QLLYSQRRADVQHLED-----DRHKTE---KIQKLREENDIARGKLEEEKKRSEELLSQV 332
+ L A VQ L+ +R + E K+ KL+ E + G L E + ++ +L V
Sbjct: 1262 KKL----EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 333 QFLYTSLLKQQE---EQTRVAL--------LEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
L + L QE E+TR L LE++ + + E +Q+++ + +
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 382 KELRKARNQITQLESLKQLHEFAITEPLVTFQGETEN-----REKVAASPK 427
+L ++ ++ S + A+ E FQ E EN EK AA K
Sbjct: 1378 IQLSDSKKKLQDFASTVE----ALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Score = 47.0 bits (110), Expect = 4e-05
Identities = 99/418 (23%), Positives = 178/418 (42%), Gaps = 71/418 (16%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E L+K K + + E+ +LT+ E++ L E+ L+AE E A E
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQ---LQAETELYA--------E 912
Query: 84 IQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIA--- 140
+ +R +L A+ ++LEE E E R L EE+D QQL A ++A
Sbjct: 913 AEEMRVRLAAKK------QELEEILHEMEAR------LEEEED-RGQQLQAERKKMAQQM 959
Query: 141 --------ELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWL---VYDQ 189
E E+ L+L + A + I M+ Q + L K ++ L + D
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDL 1018
Query: 190 QREVYVKGLLAK-IFELEKKTETAAHSLPQQTKKPE-SEGYLQEEKQKCYNDLLASAKKD 247
+ + AK + +L+ K E+ L + KK E S L++ K+K D ++
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 248 LEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKL 307
+++ Q I +L +L+ +K EE Q + L+ + + A L+ R I L
Sbjct: 1079 ADLQAQ-IAELKMQLA---KKEEELQAALARLDDEIAQKNNA----LKKIRELEGHISDL 1130
Query: 308 REENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEK 367
+E+ D R + +K+ +L +++ L T L E+ +Q+++A
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTEL----EDTLDSTATQQELRA--------- 1177
Query: 368 LDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAI---TEPLVTFQGETENREK 421
+ ++ V+ K L + R+ Q++ ++Q H A+ TE L F+ N +K
Sbjct: 1178 ----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 69.3 bits (168), Expect = 7e-12
Identities = 95/435 (21%), Positives = 182/435 (41%), Gaps = 73/435 (16%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E T + LK E+ L +S D++ K H L + R LE + E+ QL E + E
Sbjct: 1510 ERTNKMLKAEMEDLVSSKDDV--------GKNVHELEKSKRALETQMEEMKTQLEELEDE 1561
Query: 84 IQRLRD-QLKARYSTTALLEQLEETTR-----EGERREQVLKAL----SEEKDVLKQQLS 133
+Q D +L+ + AL Q E + E+R Q+ + L +E +D KQ+
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1621
Query: 134 AATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKD-------ALEKNQQWLV 186
AA ++ +LE L L A +I + +++ Q+KD A +
Sbjct: 1622 AAAAK-KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1680
Query: 187 YDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPES-----------EGYLQEEKQK 235
++ E K L A + +L++ A + Q + E LQ+EK++
Sbjct: 1681 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1740
Query: 236 CYNDLLASAKKDLEVER--------------QTITQLSFELS--------------EFRR 267
+A +++LE E+ Q QLS EL+ + R
Sbjct: 1741 L-EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1799
Query: 268 KYEETQKEVHNLNQLLYSQRRADVQHLEDD-RHKTEKIQKLREENDIARGKLEEEKKRSE 326
+ +E + ++H + + S+ ++ + LE E++++ E A L+++ K+ +
Sbjct: 1800 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1859
Query: 327 ELLSQVQFLYTSLLKQQEEQ-----TRVALLEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
E+L QV+ + +Q +EQ RV L++Q++ + + +R+ +Q +L
Sbjct: 1860 EILLQVED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1918
Query: 382 KELRKARNQITQLES 396
+ ++ L+S
Sbjct: 1919 ESNEAMGREVNALKS 1933
Score = 68.2 bits (165), Expect = 2e-11
Identities = 101/410 (24%), Positives = 171/410 (41%), Gaps = 51/410 (12%)
Query: 16 SKPSNSKSETTLEK----LKGEIAHLKTSVDEITSGKGKL-----------TDKERHR-- 58
+K + K++ TLEK L GE+ L + E+ K KL +D ER R
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284
Query: 59 LLEKIRVLEAEKEKNAYQLTEKD-KEIQRLRDQLKARYSTTALLEQLEETTREGERREQV 117
L +K+ L+ E E L E + K I+ +D E L+E TR+
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344
Query: 118 LKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAP---NCFNSSINNIHEMEIQL 174
L+ L EE++ L+ QL LE +TL + + + F S++ + E + +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1404
Query: 175 KDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYL---QE 231
+ +E Q Y+++ Y K LEK L +++ L E
Sbjct: 1405 QKEIENLTQ--QYEEKAAAYDK--------LEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1454
Query: 232 EKQKCYNDLLASAKK----------DLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQ 281
+KQ+ ++ LLA K E E + + L+ + E ++E+ N+
Sbjct: 1455 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1514
Query: 282 LLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLK 341
+L ++ D+ +DD K + +L + ++EE K + EEL ++Q + L+
Sbjct: 1515 MLKAEME-DLVSSKDDVGK--NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571
Query: 342 -QQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQ 390
+ Q E+ +QA D +NE+ RQ +Q QLH EL R Q
Sbjct: 1572 LEVNMQALKGQFERDLQA--RDEQNEEKRRQ-LQRQLHEYETELEDERKQ 1618
Score = 67.4 bits (163), Expect = 3e-11
Identities = 84/390 (21%), Positives = 161/390 (41%), Gaps = 39/390 (10%)
Query: 70 KEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLK 129
K K Q+T +++E+Q D+L+ E+ ++ E + EQ L+EEK++L+
Sbjct: 847 KVKPLLQVTRQEEEMQAKEDELQKTK------ERQQKAENELKELEQKHSQLTEEKNLLQ 900
Query: 130 QQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
+QL A T AE E L + +HEME +L++ ++ QQ
Sbjct: 901 EQLQAETELYAEAEEMRVRLAAKKQELEEI-------LHEMEARLEEEEDRGQQ---LQA 950
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
+R+ + +L +LE++ E A L + E++ E++ +D K+ +
Sbjct: 951 ERKKMAQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1009
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLRE 309
+ + I+ L+ L+E K + K + N ++ + S+ ++ E R + EK+++ E
Sbjct: 1010 LLEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1068
Query: 310 -------------ENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQM 356
+ IA K++ KK EEL + + L + ++ ++ LE +
Sbjct: 1069 GDASDFHEQIADLQAQIAELKMQLAKK-EEELQAALARLDDEIAQKNNALKKIRELEGHI 1127
Query: 357 QACTLDFENEKLDRQHVQHQ-------LHVILKELRKARNQITQLESLKQLHEFAITEPL 409
D ++E+ R + Q L + EL + + L+ E +T
Sbjct: 1128 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1187
Query: 410 VTFQGETENREKVAASPKSPTAALNESLVE 439
ET + E + A E L E
Sbjct: 1188 KALDEETRSHEAQVQEMRQKHAQAVEELTE 1217
Score = 64.7 bits (156), Expect = 2e-10
Identities = 113/471 (23%), Positives = 198/471 (42%), Gaps = 82/471 (17%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEIT--SGKGKLTDKERHRLLEKIRVL------EAEKEK 72
++ + LEK+ E A +K DEI + KER L E+I L E EK K
Sbjct: 972 ARQKLQLEKVTAE-AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1030
Query: 73 NAYQLTEKDKEI-----QRLRDQLKARYSTTALLEQLE------------------ETTR 109
N +L K + + RL+ + K+R L +LE E
Sbjct: 1031 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1090
Query: 110 EGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRL---SQTVAPNCFNSSINN 166
+ ++E+ L+A D Q + A +I ELE + L+ S+ A N +
Sbjct: 1091 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1150
Query: 167 IHE----MEIQLKDALEK--NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQT 220
+ E ++ +L+D L+ QQ L +++EV V L K + ET +H Q
Sbjct: 1151 LGEELEALKTELEDTLDSTATQQELRAKREQEVTV---LKKALD----EETRSHEAQVQE 1203
Query: 221 KKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLN 280
+ + ++E ++ + AK +L+ +QT+ + + +L+ R + ++EV +
Sbjct: 1204 MRQKHAQAVEELTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1261
Query: 281 QLLYSQRRADVQHLED-----DRHKTE---KIQKLREENDIARGKLEEEKKRSEELLSQV 332
+ L A VQ L+ +R + E K+ KL+ E + G L E + ++ +L V
Sbjct: 1262 KKL----EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1317
Query: 333 QFLYTSLLKQQE---EQTRVAL--------LEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
L + L QE E+TR L LE++ + + E +Q+++ + +
Sbjct: 1318 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1377
Query: 382 KELRKARNQITQLESLKQLHEFAITEPLVTFQGETEN-----REKVAASPK 427
+L ++ ++ S + A+ E FQ E EN EK AA K
Sbjct: 1378 IQLSDSKKKLQDFASTVE----ALEEGKKRFQKEIENLTQQYEEKAAAYDK 1424
Score = 47.0 bits (110), Expect = 4e-05
Identities = 99/418 (23%), Positives = 178/418 (42%), Gaps = 71/418 (16%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E L+K K + + E+ +LT+ E++ L E+ L+AE E A E
Sbjct: 865 EDELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQ---LQAETELYA--------E 912
Query: 84 IQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIA--- 140
+ +R +L A+ ++LEE E E R L EE+D QQL A ++A
Sbjct: 913 AEEMRVRLAAKK------QELEEILHEMEAR------LEEEED-RGQQLQAERKKMAQQM 959
Query: 141 --------ELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWL---VYDQ 189
E E+ L+L + A + I M+ Q + L K ++ L + D
Sbjct: 960 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDL 1018
Query: 190 QREVYVKGLLAK-IFELEKKTETAAHSLPQQTKKPE-SEGYLQEEKQKCYNDLLASAKKD 247
+ + AK + +L+ K E+ L + KK E S L++ K+K D ++
Sbjct: 1019 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1078
Query: 248 LEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKL 307
+++ Q I +L +L+ +K EE Q + L+ + + A L+ R I L
Sbjct: 1079 ADLQAQ-IAELKMQLA---KKEEELQAALARLDDEIAQKNNA----LKKIRELEGHISDL 1130
Query: 308 REENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEK 367
+E+ D R + +K+ +L +++ L T L E+ +Q+++A
Sbjct: 1131 QEDLDSERAARNKAEKQKRDLGEELEALKTEL----EDTLDSTATQQELRA--------- 1177
Query: 368 LDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAI---TEPLVTFQGETENREK 421
+ ++ V+ K L + R+ Q++ ++Q H A+ TE L F+ N +K
Sbjct: 1178 ----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1231
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 69.3 bits (168), Expect = 7e-12
Identities = 95/435 (21%), Positives = 182/435 (41%), Gaps = 73/435 (16%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E T + LK E+ L +S D++ K H L + R LE + E+ QL E + E
Sbjct: 1503 ERTNKMLKAEMEDLVSSKDDV--------GKNVHELEKSKRALETQMEEMKTQLEELEDE 1554
Query: 84 IQRLRD-QLKARYSTTALLEQLEETTR-----EGERREQVLKAL----SEEKDVLKQQLS 133
+Q D +L+ + AL Q E + E+R Q+ + L +E +D KQ+
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRAL 1614
Query: 134 AATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKD-------ALEKNQQWLV 186
AA ++ +LE L L A +I + +++ Q+KD A +
Sbjct: 1615 AAAAK-KKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFA 1673
Query: 187 YDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPES-----------EGYLQEEKQK 235
++ E K L A + +L++ A + Q + E LQ+EK++
Sbjct: 1674 TAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRR 1733
Query: 236 CYNDLLASAKKDLEVER--------------QTITQLSFELS--------------EFRR 267
+A +++LE E+ Q QLS EL+ + R
Sbjct: 1734 L-EARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLER 1792
Query: 268 KYEETQKEVHNLNQLLYSQRRADVQHLEDD-RHKTEKIQKLREENDIARGKLEEEKKRSE 326
+ +E + ++H + + S+ ++ + LE E++++ E A L+++ K+ +
Sbjct: 1793 QNKELRSKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAATKSLKQKDKKLK 1852
Query: 327 ELLSQVQFLYTSLLKQQEEQ-----TRVALLEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
E+L QV+ + +Q +EQ RV L++Q++ + + +R+ +Q +L
Sbjct: 1853 EILLQVED-ERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRRKLQRELDEAT 1911
Query: 382 KELRKARNQITQLES 396
+ ++ L+S
Sbjct: 1912 ESNEAMGREVNALKS 1926
Score = 68.2 bits (165), Expect = 2e-11
Identities = 101/410 (24%), Positives = 171/410 (41%), Gaps = 51/410 (12%)
Query: 16 SKPSNSKSETTLEK----LKGEIAHLKTSVDEITSGKGKL-----------TDKERHR-- 58
+K + K++ TLEK L GE+ L + E+ K KL +D ER R
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277
Query: 59 LLEKIRVLEAEKEKNAYQLTEKD-KEIQRLRDQLKARYSTTALLEQLEETTREGERREQV 117
L +K+ L+ E E L E + K I+ +D E L+E TR+
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337
Query: 118 LKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAP---NCFNSSINNIHEMEIQL 174
L+ L EE++ L+ QL LE +TL + + + F S++ + E + +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRF 1397
Query: 175 KDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYL---QE 231
+ +E Q Y+++ Y K LEK L +++ L E
Sbjct: 1398 QKEIENLTQ--QYEEKAAAYDK--------LEKTKNRLQQELDDLVVDLDNQRQLVSNLE 1447
Query: 232 EKQKCYNDLLASAKK----------DLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQ 281
+KQ+ ++ LLA K E E + + L+ + E ++E+ N+
Sbjct: 1448 KKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELERTNK 1507
Query: 282 LLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLK 341
+L ++ D+ +DD K + +L + ++EE K + EEL ++Q + L+
Sbjct: 1508 MLKAEME-DLVSSKDDVGK--NVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564
Query: 342 -QQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQ 390
+ Q E+ +QA D +NE+ RQ +Q QLH EL R Q
Sbjct: 1565 LEVNMQALKGQFERDLQA--RDEQNEEKRRQ-LQRQLHEYETELEDERKQ 1611
Score = 67.4 bits (163), Expect = 3e-11
Identities = 84/390 (21%), Positives = 161/390 (41%), Gaps = 39/390 (10%)
Query: 70 KEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLK 129
K K Q+T +++E+Q D+L+ E+ ++ E + EQ L+EEK++L+
Sbjct: 840 KVKPLLQVTRQEEEMQAKEDELQKTK------ERQQKAENELKELEQKHSQLTEEKNLLQ 893
Query: 130 QQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
+QL A T AE E L + +HEME +L++ ++ QQ
Sbjct: 894 EQLQAETELYAEAEEMRVRLAAKKQELEEI-------LHEMEARLEEEEDRGQQ---LQA 943
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
+R+ + +L +LE++ E A L + E++ E++ +D K+ +
Sbjct: 944 ERKKMAQQMLDLEEQLEEE-EAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERK 1002
Query: 250 VERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLRE 309
+ + I+ L+ L+E K + K + N ++ + S+ ++ E R + EK+++ E
Sbjct: 1003 LLEERISDLTTNLAEEEEKAKNLTK-LKNKHESMISELEVRLKKEEKSRQELEKLKRKLE 1061
Query: 310 -------------ENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQM 356
+ IA K++ KK EEL + + L + ++ ++ LE +
Sbjct: 1062 GDASDFHEQIADLQAQIAELKMQLAKK-EEELQAALARLDDEIAQKNNALKKIRELEGHI 1120
Query: 357 QACTLDFENEKLDRQHVQHQ-------LHVILKELRKARNQITQLESLKQLHEFAITEPL 409
D ++E+ R + Q L + EL + + L+ E +T
Sbjct: 1121 SDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLK 1180
Query: 410 VTFQGETENREKVAASPKSPTAALNESLVE 439
ET + E + A E L E
Sbjct: 1181 KALDEETRSHEAQVQEMRQKHAQAVEELTE 1210
Score = 64.7 bits (156), Expect = 2e-10
Identities = 113/471 (23%), Positives = 198/471 (42%), Gaps = 82/471 (17%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEIT--SGKGKLTDKERHRLLEKIRVL------EAEKEK 72
++ + LEK+ E A +K DEI + KER L E+I L E EK K
Sbjct: 965 ARQKLQLEKVTAE-AKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEEKAK 1023
Query: 73 NAYQLTEKDKEI-----QRLRDQLKARYSTTALLEQLE------------------ETTR 109
N +L K + + RL+ + K+R L +LE E
Sbjct: 1024 NLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKM 1083
Query: 110 EGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRL---SQTVAPNCFNSSINN 166
+ ++E+ L+A D Q + A +I ELE + L+ S+ A N +
Sbjct: 1084 QLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRD 1143
Query: 167 IHE----MEIQLKDALEK--NQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQT 220
+ E ++ +L+D L+ QQ L +++EV V L K + ET +H Q
Sbjct: 1144 LGEELEALKTELEDTLDSTATQQELRAKREQEVTV---LKKALD----EETRSHEAQVQE 1196
Query: 221 KKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLN 280
+ + ++E ++ + AK +L+ +QT+ + + +L+ R + ++EV +
Sbjct: 1197 MRQKHAQAVEELTEQL--EQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKK 1254
Query: 281 QLLYSQRRADVQHLED-----DRHKTE---KIQKLREENDIARGKLEEEKKRSEELLSQV 332
+ L A VQ L+ +R + E K+ KL+ E + G L E + ++ +L V
Sbjct: 1255 KKL----EAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDV 1310
Query: 333 QFLYTSLLKQQE---EQTRVAL--------LEQQMQACTLDFENEKLDRQHVQHQLHVIL 381
L + L QE E+TR L LE++ + + E +Q+++ + +
Sbjct: 1311 ASLSSQLQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLN 1370
Query: 382 KELRKARNQITQLESLKQLHEFAITEPLVTFQGETEN-----REKVAASPK 427
+L ++ ++ S + A+ E FQ E EN EK AA K
Sbjct: 1371 IQLSDSKKKLQDFASTVE----ALEEGKKRFQKEIENLTQQYEEKAAAYDK 1417
Score = 47.0 bits (110), Expect = 4e-05
Identities = 99/418 (23%), Positives = 178/418 (42%), Gaps = 71/418 (16%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E L+K K + + E+ +LT+ E++ L E+ L+AE E A E
Sbjct: 858 EDELQKTKERQQKAENELKELEQKHSQLTE-EKNLLQEQ---LQAETELYA--------E 905
Query: 84 IQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIA--- 140
+ +R +L A+ ++LEE E E R L EE+D QQL A ++A
Sbjct: 906 AEEMRVRLAAKK------QELEEILHEMEAR------LEEEED-RGQQLQAERKKMAQQM 952
Query: 141 --------ELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWL---VYDQ 189
E E+ L+L + A + I M+ Q + L K ++ L + D
Sbjct: 953 LDLEEQLEEEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQ-NNKLSKERKLLEERISDL 1011
Query: 190 QREVYVKGLLAK-IFELEKKTETAAHSLPQQTKKPE-SEGYLQEEKQKCYNDLLASAKKD 247
+ + AK + +L+ K E+ L + KK E S L++ K+K D ++
Sbjct: 1012 TTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQI 1071
Query: 248 LEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKL 307
+++ Q I +L +L+ +K EE Q + L+ + + A L+ R I L
Sbjct: 1072 ADLQAQ-IAELKMQLA---KKEEELQAALARLDDEIAQKNNA----LKKIRELEGHISDL 1123
Query: 308 REENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEK 367
+E+ D R + +K+ +L +++ L T L E+ +Q+++A
Sbjct: 1124 QEDLDSERAARNKAEKQKRDLGEELEALKTEL----EDTLDSTATQQELRA--------- 1170
Query: 368 LDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAI---TEPLVTFQGETENREK 421
+ ++ V+ K L + R+ Q++ ++Q H A+ TE L F+ N +K
Sbjct: 1171 ----KREQEVTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDK 1224
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 69.3 bits (168), Expect = 7e-12
Identities = 93/471 (19%), Positives = 202/471 (42%), Gaps = 62/471 (13%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTE-- 79
+ E T+ +L+ ++ +T + I + DK ++++ E + E E++ N Q++E
Sbjct: 1488 EQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQE---IYEKEEQFNIKQISEVQ 1544
Query: 80 -KDKEIQRLRDQLKARYSTTALLEQ--LEETTR-------------EGERREQVLKALSE 123
K E+++ ++ KA+ S +E LE T R E E ++V +AL
Sbjct: 1545 EKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMKRVQEALQI 1604
Query: 124 EKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQ 183
E+D LK+ +++ E + K Q + N + + E+E LK+ E +
Sbjct: 1605 ERDQLKENTKEIVAKMKESQEKEY-----QFLKMTAVNETQEKMCEIE-HLKEQFETQKL 1658
Query: 184 WLVYDQQREVYVKGLLAKIFELEKKTETAAHSLP--QQTKKPESEGYLQEEKQKCYNDL- 240
L + + + +L + E + L ++T K E + + ++ DL
Sbjct: 1659 NLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLE 1718
Query: 241 ----LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQR-------RA 289
L L+ ++TI +L +SE + QK++ + N L +Q R
Sbjct: 1719 KQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRI 1778
Query: 290 DVQHLEDDRH-----------KTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTS 338
HL++ + KT+K+ ++++ + + KL+E+ + + Q+ L
Sbjct: 1779 AHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKD 1838
Query: 339 LLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELR---KARNQITQLE 395
+ + Q++ + + L++Q++ +L +++ ++ +LH L+E++ K R+ + ++E
Sbjct: 1839 VNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDNLRRVE 1898
Query: 396 SLKQLHEFAITEPL-------VTFQGETENREKVAASPKSPTAALNESLVE 439
+L + E L + Q E + ++ K L E + E
Sbjct: 1899 ETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISE 1949
Score = 63.2 bits (152), Expect = 5e-10
Identities = 95/465 (20%), Positives = 200/465 (43%), Gaps = 92/465 (19%)
Query: 26 TLEKLKGEIAHLKT---SVDEITSGKGKLT---------DKERHRLLEKIRVLEAEKE-- 71
T E+LK HLK ++DE+ + T +K +L E+I VL E+E
Sbjct: 1233 TKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELL 1292
Query: 72 ---KNAYQLTEKDKEIQRLRDQLKARYSTTALL----------------EQLEETTREGE 112
K + E E++ L +Q + STT E+++ T+E +
Sbjct: 1293 PNVKEVSETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERD 1352
Query: 113 RREQVLKALSEEKDVLKQQLSAATSRIAELESK-TNTLRLSQ--------TVAPNCFNSS 163
+ + +AL + D LK+ + ++I E +SK +L + + F
Sbjct: 1353 NLKTIKEALEVKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPK 1412
Query: 164 INNIHEMEIQL--------------------KDALEKNQQWLVYD-QQREVYVKGLLAKI 202
+ + +EI++ KD L++ Q+ L + Q + +K ++AK
Sbjct: 1413 DSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKH 1472
Query: 203 FELEKKTETAAHSLPQQTK----------KPESEGYLQEEKQKCYNDLLASA-----KKD 247
E E++ + A L +Q + + E+E +++ + ND L + +K+
Sbjct: 1473 LETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKE 1532
Query: 248 LEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRH-------K 300
+ + I+++ +++E ++++E +K + Q + S+ L++ + +
Sbjct: 1533 EQFNIKQISEVQEKVNEL-KQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKE 1591
Query: 301 TEKIQKLREENDIARGKLEEEKKR-----SEELLSQVQFL-YTSLLKQQEEQTRVALLEQ 354
E++++++E I R +L+E K E + QFL T++ + QE+ + L++
Sbjct: 1592 KEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKE 1651
Query: 355 QMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQ 399
Q + L+ EN + + + LH L+E+R + L S+++
Sbjct: 1652 QFETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEE 1696
Score = 57.8 bits (138), Expect = 2e-08
Identities = 71/353 (20%), Positives = 162/353 (45%), Gaps = 39/353 (11%)
Query: 54 KERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGER 113
KE ++K+R + +EK +++ K+++ D LKA+ + E+L +
Sbjct: 1731 KEHQETIDKLRGIVSEKTN---EISNMQKDLEHSNDALKAQ--DLKIQEELRIAHMHLKE 1785
Query: 114 REQVLKAL----SEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHE 169
+++ + L SE+ D L + A+L+ K L+ ++ H+
Sbjct: 1786 QQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANE--------------HQ 1831
Query: 170 MEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYL 229
+ I LK + + Q+ + +Q + +K + +LE + A L + ++ +S +
Sbjct: 1832 L-ITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKS---V 1887
Query: 230 QEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRA 289
+E+ D L ++ L++ER QL L E + + E Q+E+ L +
Sbjct: 1888 MKER-----DNLRRVEETLKLERD---QLKESLQETKARDLEIQQELKTARMLSKEHKET 1939
Query: 290 DVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRV 349
+ E KT +I ++++ D ++ +L+++ + ++ Q+ + + ++ +
Sbjct: 1940 VDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Query: 350 ALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELR---KARNQITQL-ESLK 398
L++Q +A L ++ ++D + +LH L+E+R K R+++ ++ ESLK
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK 2052
Score = 54.7 bits (130), Expect = 2e-07
Identities = 94/447 (21%), Positives = 181/447 (40%), Gaps = 96/447 (21%)
Query: 27 LEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQR 86
+E+LK ++ + +++ + K +T+K + + LE+++ L EK+ L + + +Q
Sbjct: 889 MEQLKEQLENRDSTLQTVEREKTLITEKLQ-QTLEEVKTLTQEKD----DLKQLQESLQI 943
Query: 87 LRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKT 146
RDQLK+ T + +T + + LK E + LK ++S SR +E T
Sbjct: 944 ERDQLKSDIHDTVNMNI--DTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENT 1001
Query: 147 -----------------------NTLRLSQTVAPN-------CFNSSINNIHEMEIQLKD 176
NT L+ V N S I +E++ L+
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLES 1061
Query: 177 ALEKNQQW---------LVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEG 227
+ + +Q + + Q E+ + G EL+K+ E A KK EG
Sbjct: 1062 VIAEKEQLKTDLKENIEMTIENQEELRLLG-----DELKKQQEIVAQEKNHAIKK---EG 1113
Query: 228 YLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQR 287
L + C D LA ++ L+ + Q + + +L + + E QK+++ + L +
Sbjct: 1114 ELS---RTC--DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELK 1168
Query: 288 RADV--QHLEDDRHKTEKIQKLRE------------------------ENDIARGKLEEE 321
++ +H+E +R E QKL E E D RG + E
Sbjct: 1169 NKELTLEHMETER--LELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREI 1226
Query: 322 KKRSEELLSQVQFLYTSLLKQQE--EQTRVALLEQQMQAC-TLDFE------NEKLDRQH 372
+ + +++ + L + QE ++ R ++ E+ Q T D E E++ H
Sbjct: 1227 EATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLH 1286
Query: 373 VQHQLHVILKELRKARNQITQLESLKQ 399
+ +L +KE+ + + + +LE L +
Sbjct: 1287 EEQELLPNVKEVSETQETMNELELLTE 1313
Score = 45.8 bits (107), Expect = 8e-05
Identities = 86/408 (21%), Positives = 168/408 (41%), Gaps = 74/408 (18%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEK 80
S E L++ + EI LK ++E++ + R + +EK ++ + +EK+ Q +
Sbjct: 339 STDEALLKRYRKEIMDLKKQLEEVSL-------ETRAQAMEKDQLAQLLEEKDLLQKVQN 391
Query: 81 DKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIA 140
+K I+ L L S T L ++L+ +R+ +V L + + + +
Sbjct: 392 EK-IENLTRMLVTSSSLT-LQQELK-----AKRKRRVTWCLGKINKMKNSNYADQFNIPT 444
Query: 141 ELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQR-EVYVKGLL 199
+ +KT+ L ++ + S +++ + +E N + +Q+ E + L
Sbjct: 445 NITTKTHKLSINLLREIDESVCSESDVFSNTLDTLSEIEWNPATKLLNQENIESELNSLR 504
Query: 200 AKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLS 259
A L E +T+K E E L+E K DL+
Sbjct: 505 ADYDNLVLDYEQL------RTEKEEMELKLKE-------------KNDLD---------E 536
Query: 260 FELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLE 319
FE E + K ++ + +H ++ L + A+V + + + + K++ LRE+ D + KL+
Sbjct: 537 FEALERKTKKDQEMQLIHEISNLKNLVKHAEVYNQDLENELSSKVELLREKEDQIK-KLQ 595
Query: 320 E--EKKRSEELLSQVQFLYTSL-----LKQQEEQTRVALLEQQMQACTLDFENEKL---- 368
E + ++ E + + + S+ +KQ L+ + ++ L EN +L
Sbjct: 596 EYIDSQKLENIKMDLSYSLESIEDPKQMKQTLFDAETVALDAKRESAFLRSENLELKEKM 655
Query: 369 ------------DRQHVQHQLHV-------ILKELRKARNQITQLESL 397
D Q Q QL + KEL+ A N+IT+L SL
Sbjct: 656 KELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSL 703
Score = 44.3 bits (103), Expect = 2e-04
Identities = 59/304 (19%), Positives = 122/304 (40%), Gaps = 27/304 (8%)
Query: 76 QLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAA 135
++T+ KE+ + ++ +A LL +L+ E ER + ++ SEE ++ +
Sbjct: 721 KITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKL 780
Query: 136 TSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYV 195
S + ES+ L + E+ D + DQ+ + +
Sbjct: 781 FSEVVHKESRVQGL-----------------LEEIGKTKDDLATTQSNYKSTDQEFQNFK 823
Query: 196 KGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTI 255
L FE + K L + + + L +E QK ++ L + K +L + Q +
Sbjct: 824 T--LHMDFEQKYKMV-----LEENERMNQEIVNLSKEAQK-FDSSLGALKTELSYKTQEL 875
Query: 256 TQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIAR 315
+ + E+ E + E+ ++++ N + L + R E + E+++ L +E D +
Sbjct: 876 QEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLK 935
Query: 316 GKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQH 375
E + ++L S + + Q EQ R AL + T++ K+ + V
Sbjct: 936 QLQESLQIERDQLKSDIHDTVNMNIDTQ-EQLRNALESLKQHQETINTLKSKIS-EEVSR 993
Query: 376 QLHV 379
LH+
Sbjct: 994 NLHM 997
Score = 40.8 bits (94), Expect = 0.003
Identities = 83/404 (20%), Positives = 167/404 (41%), Gaps = 56/404 (13%)
Query: 27 LEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQR 86
LE +K ++++ S+++ K L D E L+A++E +A+ L ++ E++
Sbjct: 603 LENIKMDLSYSLESIEDPKQMKQTLFDAETV-------ALDAKRE-SAF-LRSENLELKE 653
Query: 87 LRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKT 146
+L Y QL ++ E +++ QV L+++L +A + I +L S
Sbjct: 654 KMKELATTYKQMENDIQLYQSQLEAKKKMQV---------DLEKELQSAFNEITKLTSLI 704
Query: 147 NTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYV----KGLLAKI 202
+ + C I +++ +L +E+N+ + EV + K L +++
Sbjct: 705 DGKVPKDLL---CNLELEGKITDLQKELNKEVEENEAL-----REEVILLSELKSLPSEV 756
Query: 203 FELEKKTETAA---HSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLS 259
L K+ + + H + + K SE +E + + + + K DL +
Sbjct: 757 ERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTD 816
Query: 260 FELSEFR-------RKYEETQKEVHNLNQLLYSQRRADVQHLEDDRH--KTEKIQKLREE 310
E F+ +KY+ +E +NQ + + + + Q + KTE K +E
Sbjct: 817 QEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSK-EAQKFDSSLGALKTELSYKTQEL 875
Query: 311 NDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDR 370
+ R +++E E+L Q++ ++L + E+T + QQ EK D
Sbjct: 876 QEKTR-EVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934
Query: 371 QHVQHQLHVILKELRK-----------ARNQI-TQLESLKQLHE 402
+ +Q L + +L+ + Q+ LESLKQ E
Sbjct: 935 KQLQESLQIERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQE 978
Score = 39.3 bits (90), Expect = 0.008
Identities = 93/456 (20%), Positives = 177/456 (38%), Gaps = 67/456 (14%)
Query: 54 KERHRLLEKIR---VLEAEKEKNAY---QLTEKDKEI--QRLRDQLKARYSTTALLEQLE 105
+E+H + K + E EK+K Q ++D ++ + LRD LK + +E++
Sbjct: 2185 EEQHESINKFEMDFIDEVEKQKELLIKIQHLQQDCDVPSRELRD-LKLNQNMDLHIEEIL 2243
Query: 106 ETTREGE-------------RREQVLKALSE------EKDVLKQQLSAATSRIAELESKT 146
+ E E R+++ + L E + + LK + RI ++ +
Sbjct: 2244 KDFSESEFPSIKTEFQQVLSNRKEMTQFLEEWLNTRFDIEKLKNGIQKENDRICQVNNFF 2303
Query: 147 NTLRLSQTVAPNCFNSSINNIH-EMEIQLKDALEKNQQWLV-YDQQREVYVKGLLAKIFE 204
N ++ F I E E LK EKN++ Y + G
Sbjct: 2304 NNRIIAIMNESTEFEERSATISKEWEQDLKSLKEKNEKLFKNYQTLKTSLASGAQVNPTT 2363
Query: 205 LEKKTETAAHSLPQQT--KKPESEGYLQEEKQKCYN--DLLASAKKDLEVERQTITQLSF 260
+ K Q T K E E L E K+ + + +K+LEV I +L
Sbjct: 2364 QDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQKELEVTNDIIAKLQA 2423
Query: 261 ELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKI--QKLREENDIARGKL 318
++ E + E+T++ + L + + + +ED + K KI +K++ + + ++
Sbjct: 2424 KVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKIDLEKMKNAKEFEK-EI 2482
Query: 319 EEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLE--------------------QQMQA 358
K E ++ L +L + Q+ Q + E Q +A
Sbjct: 2483 SATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKPLTCGGGSGIVQNTKA 2542
Query: 359 CTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETEN 418
L E+ +L+++ +L ++L K +N++ L + + L T T + E
Sbjct: 2543 LILKSEHIRLEKE--ISKLKQQNEQLIKQKNEL--LSNNQHLSNEVKTWKERTLKREAHK 2598
Query: 419 REKVAASPKSP----TAALNESLV--ECPKCNIQYP 448
+ SPKSP TA+ + + +C + N+Q P
Sbjct: 2599 QVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDP 2634
>gi|110611903 myosin, heavy polypeptide 4, skeletal muscle [Homo
sapiens]
Length = 1939
Score = 68.9 bits (167), Expect = 9e-12
Identities = 97/448 (21%), Positives = 195/448 (43%), Gaps = 56/448 (12%)
Query: 28 EKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRL 87
+KL+ E + LK ++++ S + K + + R LE + ++ K++E QRL
Sbjct: 1219 QKLEKEKSELKMEINDLASNM-ETVSKAKANFEKMCRTLEDQLS----EIKTKEEEQQRL 1273
Query: 88 RDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAE-LESKT 146
++L A+ + L + E +R+ + ++ ++ LS K QQ+ ++ E ++K+
Sbjct: 1274 INELSAQKAR--LHTESGEFSRQLDEKDAMVSQLSRGKQAFTQQIEELKRQLEEETKAKS 1331
Query: 147 NTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYD--QQREVYVKGLLAKIFE 204
Q+ +C + +E E + K L++ + Q R Y + + E
Sbjct: 1332 TLAHALQSARHDC--DLLREQYEEEQEAKAELQRGMSKANSEVAQWRTKYETDAIQRTEE 1389
Query: 205 LEKKTETAAHSLPQQTKKPESEGY----LQEEKQKCYNDLLASAKKDL--EVERQTITQL 258
LE+ + A L + E+ L++ KQ+ N++ +DL +VER +
Sbjct: 1390 LEEAKKKLAQRLQDAEEHVEAVNSKCASLEKTKQRLQNEV-----EDLMIDVERSNAACI 1444
Query: 259 SFE---------LSEFRRKYEET-------QKEVHNLNQLLYSQRRA---DVQHLEDDRH 299
+ + L+E+++KYEET QKE +L+ L+ + A + HLE +
Sbjct: 1445 ALDKKQRNFDKVLAEWKQKYEETQAELEASQKESRSLSTELFKVKNAYEESLDHLETLKR 1504
Query: 300 KTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQAC 359
+ + +Q +E +D+ ++ E K EL +K+Q + + + L+ ++
Sbjct: 1505 ENKNLQ--QEISDLTE-QIAEGGKHIHEL---------EKVKKQLDHEK-SELQTSLEEA 1551
Query: 360 TLDFENEKLDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAITEPLVTFQGETEN 418
E+E+ +Q +L+ + E+ RK + +L+ LK+ H + T E +
Sbjct: 1552 EASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELDQLKRNHLRVVESMQSTLDAEIRS 1611
Query: 419 REKVAASPKSPTAALNESLVECPKCNIQ 446
R K LNE ++ N Q
Sbjct: 1612 RNDALRIKKKMEGDLNEMEIQLNHANRQ 1639
Score = 51.2 bits (121), Expect = 2e-06
Identities = 77/412 (18%), Positives = 162/412 (39%), Gaps = 14/412 (3%)
Query: 8 DLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLE 67
+L K K S+ +T+LE+ + + H + + I ++ + ++ EK L+
Sbjct: 1529 ELEKVKKQLDHEKSELQTSLEEAEASLEHEEGKILRIQLELNQVKSEIDRKIAEKDEELD 1588
Query: 68 AEKEKNAYQLTEK-----DKEIQRLRDQLKARYSTTALLEQLEETTREGERRE-QVLKAL 121
K +N ++ E D EI+ D L+ + L ++E R+ + L+ L
Sbjct: 1589 QLK-RNHLRVVESMQSTLDAEIRSRNDALRIKKKMEGDLNEMEIQLNHANRQAAEALRNL 1647
Query: 122 SEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKN 181
+ +LK I + L + + A N + + + + + +
Sbjct: 1648 RNTQGILKDTQLHLDDAIRGQDDLKEQLAMVERRA-NLMQAEVEELRASLERTERGRKMA 1706
Query: 182 QQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLL 241
+Q L+ +R + + +KK ET + + + E EEK K
Sbjct: 1707 EQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDIVQEARNAEEKAKKAITDA 1766
Query: 242 ASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDD-RHK 300
A ++L+ E+ T L + ++ Q + QL + +Q LE R
Sbjct: 1767 AMMAEELKKEQDTSAHLERMKKNMEQTVKDLQLRLDEAEQLALKGGKKQIQKLEARVREL 1826
Query: 301 TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQE----EQTRVALLEQQM 356
+++ ++ N A L + ++R +EL Q + ++L+ Q+ QT+V ++Q
Sbjct: 1827 ESEVESEQKHNVEAVKGLRKHERRVKELTYQTEEDRKNILRLQDLVDKLQTKVKAYKRQA 1886
Query: 357 QACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLE-SLKQLHEFAITE 407
+ + +QH+L + A +Q+ +L +++H I+E
Sbjct: 1887 EEAEEQSNVNLAKFRKLQHELEEAKERADIAESQVNKLRVKSREVHTKVISE 1938
Score = 50.8 bits (120), Expect = 3e-06
Identities = 86/410 (20%), Positives = 157/410 (38%), Gaps = 56/410 (13%)
Query: 17 KPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQ 76
KP +ET + E+A++K ++ K T+ +R L EK+ L EK Q
Sbjct: 841 KPLLKSAET-----EKEMANMKEEFEKTKEELAK-TEAKRKELEEKMVTLMQEKNDLQLQ 894
Query: 77 LTEKDKEIQRLRDQLKARYSTTALLE-QLEETTREGERREQVLKALSEEKDVLKQQLSAA 135
+ + + ++ T LE +++E T E E++ L+ +K L+ + S
Sbjct: 895 VQAEADALADAEERCDQLIKTKIQLEAKIKEVTERAEDEEEINAELTAKKRKLEDECSEL 954
Query: 136 TSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYV 195
I +LE + + N + N+ E L + + K
Sbjct: 955 KKDIDDLELTLAKVEKEKHATEN----KVKNLTEEMAGLDETIAK--------------- 995
Query: 196 KGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTI 255
L K EKK AH QQT LQ E+ K + L AK LE Q +
Sbjct: 996 ---LTK----EKKALQEAH---QQTLDD-----LQMEEDKV--NTLTKAKTKLE---QQV 1035
Query: 256 TQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIAR 315
L L + ++ + ++ L L + + + D + EK++K E +
Sbjct: 1036 DDLEGSLEQEKKLCMDLERAKRKLEGDLKLAQESTMDTENDKQQLNEKLKKKEFEMSNLQ 1095
Query: 316 GKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQH 375
GK+E+E+ + +L ++ +E Q R+ LE++++A + R +
Sbjct: 1096 GKIEDEQALAIQLQKKI----------KELQARIEELEEEIEAERASRAKAEKQRSDLSR 1145
Query: 376 QLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAAS 425
+L I + L +A + + + E + + T E AA+
Sbjct: 1146 ELEEISERLEEAGGATSAQIEMNKKREAEFQKMRRDLEESTLQHEATAAA 1195
>gi|134304846 Rb1-inducible coiled coil protein 1 isoform 2 [Homo
sapiens]
Length = 1591
Score = 68.6 bits (166), Expect = 1e-11
Identities = 97/409 (23%), Positives = 181/409 (44%), Gaps = 56/409 (13%)
Query: 33 EIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLK 92
++ H++ +T + L + ++ E +++ +E +A + EK+K++Q L+ ++
Sbjct: 996 QVRHIQEFEKVMTDHRVSLEELKK----ENQQIINQIQESHAEIIQEKEKQLQELKLKVS 1051
Query: 93 ARYSTTALLEQLEETTREGERREQVLKALSEE-----KDVLKQQLSAATSRIAELESKTN 147
T LE +E +E E E +K L EE K+ LK L T + SK N
Sbjct: 1052 DLSDTRCKLE-VELALKEAETDE--IKILLEESRAQQKETLKSLLEQETENLRTEISKLN 1108
Query: 148 T---------------LRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQRE 192
LR T+ + S + + HE E + A E N+ +++Q E
Sbjct: 1109 QKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKA-ELNKVTSLHNQAFE 1167
Query: 193 VYVKGLLAKIFELEKKTETAAHSLPQQ-----TKKPESEGYLQEEKQKCYNDLLASAKKD 247
+ K L +I EL+ K ++ +L +Q T++ E + + +K L++S ++D
Sbjct: 1168 IE-KNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQD 1226
Query: 248 LEVERQTITQLSFE--------LSEFRRKYEETQKE----VHNLNQLLYSQRRADVQHLE 295
E Q I +L+ E L EF+ + E +KE V +L + D +
Sbjct: 1227 RE---QLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGD 1283
Query: 296 DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQ 355
E +KL+EE +LEE++KR E ++Q + TSL+ +Q+ L ++
Sbjct: 1284 SSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE---EMQNVRTSLIAEQQTNFNTVLTREK 1340
Query: 356 MQACTL--DFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHE 402
M+ + D ++ Q + +++ L + R ++ LE K+L E
Sbjct: 1341 MRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARL--LEEKKKLEE 1387
Score = 46.6 bits (109), Expect = 5e-05
Identities = 58/248 (23%), Positives = 113/248 (45%), Gaps = 29/248 (11%)
Query: 168 HEMEI-QLKDALEKNQQWLVYD-QQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPES 225
H+ E+ LK+ E L+ + ++ E +K L ++ LE+ + + + E+
Sbjct: 863 HQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEA 922
Query: 226 EGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYE---ETQKEVHNLNQL 282
LQ EK + K LE+E +Q + E+ E ++ E E K++H N
Sbjct: 923 VICLQNEKDQ----------KLLEMENIMHSQ-NCEIKELKQSREIVLEDLKKLHVENDE 971
Query: 283 LYSQRRADVQHLE-------DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFL 335
RA++Q LE +D + IQ+ + R LEE KK ++++++Q+Q
Sbjct: 972 KLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQES 1031
Query: 336 YTSLLKQQEEQTR-VALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQL 394
+ +++++E+Q + + L + E E ++ ++ ++L+E R Q
Sbjct: 1032 HAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESR-----AQQK 1086
Query: 395 ESLKQLHE 402
E+LK L E
Sbjct: 1087 ETLKSLLE 1094
Score = 31.6 bits (70), Expect = 1.6
Identities = 25/102 (24%), Positives = 48/102 (47%), Gaps = 21/102 (20%)
Query: 66 LEAEKEKNAYQLTEKDK----EIQRLRDQLKARYSTTA-----------------LLEQL 104
L+ EK K QL E++K E+Q +R L A T L ++L
Sbjct: 1295 LQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKL 1354
Query: 105 EETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKT 146
+ T ++ ER + ++++LSE++ L ++ +++L S +
Sbjct: 1355 KSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSS 1396
>gi|134304842 Rb1-inducible coiled coil protein 1 isoform 1 [Homo
sapiens]
Length = 1594
Score = 68.6 bits (166), Expect = 1e-11
Identities = 97/409 (23%), Positives = 181/409 (44%), Gaps = 56/409 (13%)
Query: 33 EIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLK 92
++ H++ +T + L + ++ E +++ +E +A + EK+K++Q L+ ++
Sbjct: 996 QVRHIQEFEKVMTDHRVSLEELKK----ENQQIINQIQESHAEIIQEKEKQLQELKLKVS 1051
Query: 93 ARYSTTALLEQLEETTREGERREQVLKALSEE-----KDVLKQQLSAATSRIAELESKTN 147
T LE +E +E E E +K L EE K+ LK L T + SK N
Sbjct: 1052 DLSDTRCKLE-VELALKEAETDE--IKILLEESRAQQKETLKSLLEQETENLRTEISKLN 1108
Query: 148 T---------------LRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQRE 192
LR T+ + S + + HE E + A E N+ +++Q E
Sbjct: 1109 QKIQDNNENYQVGLAELRTLMTIEKDQCISELISRHEEESNILKA-ELNKVTSLHNQAFE 1167
Query: 193 VYVKGLLAKIFELEKKTETAAHSLPQQ-----TKKPESEGYLQEEKQKCYNDLLASAKKD 247
+ K L +I EL+ K ++ +L +Q T++ E + + +K L++S ++D
Sbjct: 1168 IE-KNLKEQIIELQSKLDSELSALERQKDEKITQQEEKYEAIIQNLEKDRQKLVSSQEQD 1226
Query: 248 LEVERQTITQLSFE--------LSEFRRKYEETQKE----VHNLNQLLYSQRRADVQHLE 295
E Q I +L+ E L EF+ + E +KE V +L + D +
Sbjct: 1227 RE---QLIQKLNCEKDEAIQTALKEFKLEREVVEKELLEKVKHLENQIAKSPAIDSTRGD 1283
Query: 296 DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQ 355
E +KL+EE +LEE++KR E ++Q + TSL+ +Q+ L ++
Sbjct: 1284 SSSLVAELQEKLQEEKAKFLEQLEEQEKRKNE---EMQNVRTSLIAEQQTNFNTVLTREK 1340
Query: 356 MQACTL--DFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHE 402
M+ + D ++ Q + +++ L + R ++ LE K+L E
Sbjct: 1341 MRKENIINDLSDKLKSTMQQQERDKDLIESLSEDRARL--LEEKKKLEE 1387
Score = 46.6 bits (109), Expect = 5e-05
Identities = 58/248 (23%), Positives = 113/248 (45%), Gaps = 29/248 (11%)
Query: 168 HEMEI-QLKDALEKNQQWLVYD-QQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPES 225
H+ E+ LK+ E L+ + ++ E +K L ++ LE+ + + + E+
Sbjct: 863 HQKELLSLKNEYEGKLDGLIKETEENENKIKKLKGELVCLEEVLQNKDNEFALVKHEKEA 922
Query: 226 EGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYE---ETQKEVHNLNQL 282
LQ EK + K LE+E +Q + E+ E ++ E E K++H N
Sbjct: 923 VICLQNEKDQ----------KLLEMENIMHSQ-NCEIKELKQSREIVLEDLKKLHVENDE 971
Query: 283 LYSQRRADVQHLE-------DDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFL 335
RA++Q LE +D + IQ+ + R LEE KK ++++++Q+Q
Sbjct: 972 KLQLLRAELQSLEQSHLKELEDTLQVRHIQEFEKVMTDHRVSLEELKKENQQIINQIQES 1031
Query: 336 YTSLLKQQEEQTR-VALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQL 394
+ +++++E+Q + + L + E E ++ ++ ++L+E R Q
Sbjct: 1032 HAEIIQEKEKQLQELKLKVSDLSDTRCKLEVELALKEAETDEIKILLEESR-----AQQK 1086
Query: 395 ESLKQLHE 402
E+LK L E
Sbjct: 1087 ETLKSLLE 1094
Score = 31.6 bits (70), Expect = 1.6
Identities = 25/102 (24%), Positives = 48/102 (47%), Gaps = 21/102 (20%)
Query: 66 LEAEKEKNAYQLTEKDK----EIQRLRDQLKARYSTTA-----------------LLEQL 104
L+ EK K QL E++K E+Q +R L A T L ++L
Sbjct: 1295 LQEEKAKFLEQLEEQEKRKNEEMQNVRTSLIAEQQTNFNTVLTREKMRKENIINDLSDKL 1354
Query: 105 EETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKT 146
+ T ++ ER + ++++LSE++ L ++ +++L S +
Sbjct: 1355 KSTMQQQERDKDLIESLSEDRARLLEEKKKLEEEVSKLRSSS 1396
>gi|115496169 myosin, heavy chain 7, cardiac muscle, beta [Homo
sapiens]
Length = 1935
Score = 68.2 bits (165), Expect = 2e-11
Identities = 92/433 (21%), Positives = 180/433 (41%), Gaps = 49/433 (11%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKER--HRLLEKIRVLEAEKEKNAYQLTE 79
K++ LEK+ +T D++ + K + +R + L + L+ E + + QL E
Sbjct: 1240 KAKANLEKM------CRTLEDQMNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQLDE 1293
Query: 80 KDKEIQRL-RDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSR 138
K+ I +L R +L L QLEE + L++ + D+L++Q T
Sbjct: 1294 KEALISQLTRGKLTYTQQLEDLKRQLEEEVKAKNALAHALQSARHDCDLLREQYEEETEA 1353
Query: 139 IAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGL 198
AEL+ + + + VA + I E +L++A +K Q L Q+ E V+ +
Sbjct: 1354 KAELQRVLS--KANSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRL---QEAEEAVEAV 1407
Query: 199 LAKIFELEK---KTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTI 255
AK LEK + + L ++ + ++KQ+ ++ +LA K+ E
Sbjct: 1408 NAKCSSLEKTKHRLQNEIEDLMVDVERSNAAAAALDKKQRNFDKILAEWKQKYE------ 1461
Query: 256 TQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRA---DVQHLEDDRHKTEKIQKLREEND 312
E + + E +QKE +L+ L+ + A ++HLE + + + +Q
Sbjct: 1462 --------ESQSELESSQKEARSLSTELFKLKNAYEESLEHLETFKRENKNLQ------- 1506
Query: 313 IARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQH 372
EE +E+L S + ++ +++ + L+ ++ E+E+
Sbjct: 1507 ------EEISDLTEQLGSSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILR 1560
Query: 373 VQHQLHVILKEL-RKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSPTA 431
Q + + I E+ RK + ++E K+ H + + ET +R + K
Sbjct: 1561 AQLEFNQIKAEIERKLAEKDEEMEQAKRNHLRVVDSLQTSLDAETRSRNEALRVKKKMEG 1620
Query: 432 ALNESLVECPKCN 444
LNE ++ N
Sbjct: 1621 DLNEMEIQLSHAN 1633
Score = 53.1 bits (126), Expect = 5e-07
Identities = 89/428 (20%), Positives = 172/428 (40%), Gaps = 63/428 (14%)
Query: 34 IAHLKTSVDEITSGKGKLTDK--ERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQL 91
+A + D++ K +L K E + LE + AE +L ++ E++R D L
Sbjct: 898 LADAEERCDQLIKNKIQLEAKVKEMNERLEDEEEMNAELTAKKRKLEDECSELKRDIDDL 957
Query: 92 -----KARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKT 146
K A +++ T E ++++ L++EK L++ A + E K
Sbjct: 958 ELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKALQEAHQQALDDLQAEEDKV 1017
Query: 147 NTL-----RLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAK 201
NTL +L Q V + S+ ++ + L+ A K + L Q+ + ++ +
Sbjct: 1018 NTLTKAKVKLEQQV--DDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDLENDKQQ 1075
Query: 202 IFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVER-------QT 254
+ E KK + ++L + + ++ G ++K K + +++LE ER +
Sbjct: 1076 LDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQARIEELEEELEAERTARAKVEKL 1135
Query: 255 ITQLSFELSEFRRKYEE------TQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLR 308
+ LS EL E + EE Q E++ + + + R D++ T + +
Sbjct: 1136 RSDLSRELEEISERLEEAGGATSVQIEMNKKREAEFQKMRRDLEEATLQHEATAAALRKK 1195
Query: 309 EENDIA------------RGKLEEEKKRSEELLSQVQFLYTSLLK--------------- 341
+ +A + KLE+EK + L V ++K
Sbjct: 1196 HADSVAELGEQIDNLQRVKQKLEKEKSEFKLELDDVTSNMEQIIKAKANLEKMCRTLEDQ 1255
Query: 342 -----QQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQIT-QLE 395
+ E+T+ ++ + Q L EN +L RQ + ++ +L + + T QLE
Sbjct: 1256 MNEHRSKAEETQRSVNDLTSQRAKLQTENGELSRQ--LDEKEALISQLTRGKLTYTQQLE 1313
Query: 396 SLK-QLHE 402
LK QL E
Sbjct: 1314 DLKRQLEE 1321
Score = 53.1 bits (126), Expect = 5e-07
Identities = 80/418 (19%), Positives = 164/418 (39%), Gaps = 45/418 (10%)
Query: 19 SNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLT 78
S+ K+ LEK++ ++ K + + E ++L K + +L
Sbjct: 1518 SSGKTIHELEKVRKQLEAEKMELQSALEEAEASLEHEEGKILRAQLEFNQIKAEIERKLA 1577
Query: 79 EKDKEIQRL-RDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATS 137
EKD+E+++ R+ L+ +L L+ TR +V K + + + ++ QLS A
Sbjct: 1578 EKDEEMEQAKRNHLRV---VDSLQTSLDAETRSRNEALRVKKKMEGDLNEMEIQLSHANR 1634
Query: 138 RIAELESKTNTLR-------------------LSQTVA-----PNCFNSSINNIHEMEIQ 173
AE + + +L+ L + +A N + + + + Q
Sbjct: 1635 MAAEAQKQVKSLQSLLKDTQIQLDDAVRANDDLKENIAIVERRNNLLQAELEELRAVVEQ 1694
Query: 174 LKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEK 233
+ + + +Q L+ +R + + +KK + L + ++ E EEK
Sbjct: 1695 TERSRKLAEQELIETSERVQLLHSQNTSLINQKKKMDADLSQLQTEVEEAVQECRNAEEK 1754
Query: 234 QKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQH 293
K A ++L+ E+ T S L ++ E+T K++ Q R D
Sbjct: 1755 AKKAITDAAMMAEELKKEQDT----SAHLERMKKNMEQTIKDL---------QHRLDEAE 1801
Query: 294 LEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSL--LKQQEEQTRVAL 351
+ +++QKL +LE E+KR+ E + ++ + L Q E+ R L
Sbjct: 1802 QIALKGGKKQLQKLEARVRELENELEAEQKRNAESVKGMRKSERRIKELTYQTEEDRKNL 1861
Query: 352 LEQQ--MQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITE 407
L Q + L + K + + Q + L + RK ++++ + E + E + +
Sbjct: 1862 LRLQDLVDKLQLKVKAYKRQAEEAEEQANTNLSKFRKVQHELDEAEERADIAESQVNK 1919
Score = 47.8 bits (112), Expect = 2e-05
Identities = 77/283 (27%), Positives = 120/283 (42%), Gaps = 26/283 (9%)
Query: 114 REQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQ 173
RE+ + ++ EE LK+ L + +R ELE K +L + N + +
Sbjct: 845 REKEMASMKEEFTRLKEALEKSEARRKELEEKMVSLLQEK-------NDLQLQVQAEQDN 897
Query: 174 LKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEK 233
L DA E+ Q + Q E VK + + LE + E A L + +K E E E
Sbjct: 898 LADAEERCDQLIKNKIQLEAKVKEMNER---LEDEEEMNA-ELTAKKRKLEDE---CSEL 950
Query: 234 QKCYNDL---LASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRAD 290
++ +DL LA +K+ + L+ E++ + KE L Q + Q D
Sbjct: 951 KRDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDEIIAKLTKEKKAL-QEAHQQALDD 1009
Query: 291 VQHLEDDRHKTEKIQ-KLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRV 349
+Q ED + K + KL ++ D G LE+EKK +L + L L QE +
Sbjct: 1010 LQAEEDKVNTLTKAKVKLEQQVDDLEGSLEQEKKVRMDLERAKRKLEGDLKLTQESIMDL 1069
Query: 350 ALLEQQM--QACTLDFENEKL-----DRQHVQHQLHVILKELR 385
+QQ+ + DFE L D Q + QL LKEL+
Sbjct: 1070 ENDKQQLDERLKKKDFELNALNARIEDEQALGSQLQKKLKELQ 1112
>gi|110624781 myosin, heavy polypeptide 13, skeletal muscle [Homo
sapiens]
Length = 1938
Score = 68.2 bits (165), Expect = 2e-11
Identities = 95/444 (21%), Positives = 191/444 (43%), Gaps = 55/444 (12%)
Query: 21 SKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEK 80
SKS++ +E+ +T D+ + K K D+++ +L+ + + +A + +L+ +
Sbjct: 1243 SKSKSNIERT------CRTVEDQFSEIKAK--DEQQTQLIHDLNMQKARLQTQNGELSHR 1294
Query: 81 DKEIQRLRDQL-KARYSTTALLE----QLEETTREGERREQVLKALSEEKDVLKQQLSAA 135
+E + L QL K++ + T LE Q+EE T+ L++ + D+L++Q
Sbjct: 1295 VEEKESLISQLTKSKQALTQQLEELKRQMEEETKAKNAMAHALQSSRHDCDLLREQYEEE 1354
Query: 136 TSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYV 195
AEL+ + + + VA + I E +L++A +K Q L ++
Sbjct: 1355 QEAKAELQRALS--KANSEVAQWRTKYETDAIQRTE-ELEEAKKKLAQRLQEAEENTETA 1411
Query: 196 KGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKK-------DL 248
A + + +++ + L + ++ + ++KQ+ ++ +LA K+ +L
Sbjct: 1412 NSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEWKQKLDESQAEL 1471
Query: 249 EVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLR 308
E ++ LS EL + R YEE ++ L + ++++ E+I L
Sbjct: 1472 EAAQKESRSLSTELFKMRNAYEEVVDQLETLRR--------------ENKNLQEEISDLT 1517
Query: 309 EENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKL 368
E+ L+E +K + L++Q++ +VAL E + +L+ E K+
Sbjct: 1518 EQIAETGKNLQEAEKTKK------------LVEQEKSDLQVALEEVE---GSLEHEESKI 1562
Query: 369 DRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPK 427
R VQ +L + EL RK + ++E LK+ + A E +R K
Sbjct: 1563 LR--VQLELSQVKSELDRKVIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRNDALRLKK 1620
Query: 428 SPTAALNESLVECPKCNIQYPATE 451
LNE ++ N Q T+
Sbjct: 1621 KMEGDLNEMEIQLGHSNRQMAETQ 1644
Score = 65.9 bits (159), Expect = 8e-11
Identities = 102/414 (24%), Positives = 173/414 (41%), Gaps = 60/414 (14%)
Query: 7 KDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVL 66
K L+KS K + E E+ K E+A ++ R L EK+ L
Sbjct: 841 KPLLKSAEAEKEMATMKED-FERTKEELAR---------------SEARRKELEEKMVSL 884
Query: 67 EAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLE-QLEETTREGERREQVLKALSEEK 125
EK Q+ + + + ++ + + LLE +++E T E E++ L +K
Sbjct: 885 LQEKNDLQLQVQSETENLMDAEERCEGLIKSKILLEAKVKELTERLEEEEEMNSELVAKK 944
Query: 126 DVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSIN-------NIHEMEIQLKDAL 178
L+ + S+ I +LE + + N + NI ++ + K
Sbjct: 945 RNLEDKCSSLKRDIDDLELTLTKVEKEKHATENKVKNLSEEMTALEENISKLTKEKKSLQ 1004
Query: 179 EKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYN 238
E +QQ L Q E V GL+ +LE++T+ SL Q+ K L+ K+K
Sbjct: 1005 EAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKK---LRADLERAKRKLEG 1061
Query: 239 DLLASAKK--DLEVERQTITQ----LSFELSEFRRKYEETQKEVHNLN-QLLYSQRRADV 291
DL S + DLE ++Q I + FELS+ + K ++ Q VH+L Q + +A +
Sbjct: 1062 DLKMSQESIMDLENDKQQIEEKLKKKEFELSQLQAKIDDEQ--VHSLQFQKKIKELQARI 1119
Query: 292 QHLEDD-------RHKTEK------------IQKLREENDIARGKLEEEKKRSEELLSQV 332
+ LE++ R K EK ++L E + ++E KKR E
Sbjct: 1120 EELEEEIEAEHTLRAKIEKQRSDLARELEEISERLEEASGATSAQIEMNKKREAEFQKMR 1179
Query: 333 QFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDR-QHVQHQLHVILKELR 385
+ L + L Q E T L ++ QA ++ E++D Q V+ +L EL+
Sbjct: 1180 RDLEEATL--QHEATAATL--RKKQADSVAELGEQIDNLQRVKQKLEKEKSELK 1229
Score = 53.5 bits (127), Expect = 4e-07
Identities = 98/475 (20%), Positives = 196/475 (41%), Gaps = 76/475 (16%)
Query: 9 LIKSKWGSKPSNSKS---ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERH-------- 57
L +++ ++ +NSK E T ++L+GE+ L ++ + L K+R+
Sbjct: 1401 LQEAEENTETANSKCASLEKTKQRLQGEVEDLMRDLERSHTACATLDKKQRNFDKVLAEW 1460
Query: 58 --RLLEKIRVLEAE------------KEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQ 103
+L E LEA K +NAY+ E R R+ + + L EQ
Sbjct: 1461 KQKLDESQAELEAAQKESRSLSTELFKMRNAYEEVVDQLETLR-RENKNLQEEISDLTEQ 1519
Query: 104 LEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSS 163
+ ET + + E+ K + +EK L+ L + ESK ++L + + +
Sbjct: 1520 IAETGKNLQEAEKTKKLVEQEKSDLQVALEEVEGSLEHEESKILRVQLELSQVKSELDRK 1579
Query: 164 INNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQ---- 219
+ E QLK ++ + L E+ + L+KK E + + Q
Sbjct: 1580 VIEKDEEIEQLKRNSQRAAEALQSVLDAEIRSRN---DALRLKKKMEGDLNEMEIQLGHS 1636
Query: 220 -TKKPESEGYLQ------EEKQKCYNDLLAS---AKKDLEVERQTITQLSFELSEFRRKY 269
+ E++ +L+ ++ Q +D L S K+ L + + L EL E +
Sbjct: 1637 NRQMAETQKHLRTVQGQLKDSQLHLDDALRSNEDLKEQLAIVERRNGLLLEELEEMKVAL 1696
Query: 270 EETQK----------EVHNLNQLLYSQRRADV---QHLEDDRHKTEKIQKLREENDIARG 316
E+T++ + + QLL+SQ + + + LE D + + EN I
Sbjct: 1697 EQTERTRRLSEQELLDASDRVQLLHSQNTSLINTKKKLEADIAQCQ----AEVENSIQES 1752
Query: 317 KLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQ 376
+ EEK +++ ++ + L K+Q+ + +++ ++ D ++ +LD Q
Sbjct: 1753 RNAEEK--AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQH-RLDEAE-QLA 1808
Query: 377 LHVILKELRKARNQITQL------------ESLKQLHEFAITEPLVTFQGETENR 419
L K+++K N++ +L E+LK H++ +T+Q E +++
Sbjct: 1809 LKGGKKQIQKLENRVRELENELDVEQKRGAEALKGAHKYERKVKEMTYQAEEDHK 1863
>gi|98986453 myosin, heavy chain 3, skeletal muscle, embryonic [Homo
sapiens]
Length = 1940
Score = 67.8 bits (164), Expect = 2e-11
Identities = 97/465 (20%), Positives = 193/465 (41%), Gaps = 74/465 (15%)
Query: 3 SRSTKDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDK--ERHRLL 60
S S + + KSK + E L + +G+ ++ S+ E+T+ K +L + E R L
Sbjct: 1233 SSSMESVSKSKANLEKICRTLEDQLSEARGKNEEIQRSLSELTTQKSRLQTEAGELSRQL 1292
Query: 61 EKIRVLEAEKEKNAYQLTEKDKEIQR-LRDQLKARYSTTALLEQLEETTREGERREQVLK 119
E+ + ++ ++ T++ +E++R L ++ KA+ AL L+ + + + + +
Sbjct: 1293 EEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAK---NALAHALQSSRHDCDLLREQYE 1349
Query: 120 ALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALE 179
E K L++ LS A S +A+ +K T + +T +L++A +
Sbjct: 1350 EEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTE-----------------ELEEAKK 1392
Query: 180 KNQQWLVYDQQREVYVKGLLAKIFELEK---KTETAAHSLPQQTKKPESEGYLQEEKQKC 236
K Q L Q E V+ + AK LEK + + L ++ S ++KQ+
Sbjct: 1393 KLAQRL---QDSEEQVEAVNAKCASLEKTKQRLQGEVEDLMVDVERANSLAAALDKKQRN 1449
Query: 237 YNDLLA-------SAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRA 289
++ +LA ++ +LE + LS EL + + YEE ++ + +
Sbjct: 1450 FDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKR-------- 1501
Query: 290 DVQHLEDDRHKTEKIQKLRE---ENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQ 346
++++ ++I L E EN +LE+ +K+ E + +Q E+
Sbjct: 1502 ------ENKNLEQEIADLTEQIAENGKTIHELEKSRKQIELEKADIQLAL--------EE 1547
Query: 347 TRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAI 405
AL E+E+ +Q +L + E+ RK + ++E LK+ ++ +
Sbjct: 1548 AEAAL------------EHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTV 1595
Query: 406 TEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQYPAT 450
E +R + K LNE ++ N Q T
Sbjct: 1596 ETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANRQAAET 1640
Score = 57.0 bits (136), Expect = 4e-08
Identities = 81/404 (20%), Positives = 173/404 (42%), Gaps = 62/404 (15%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKE 83
E T ++L+GE+ L V+ S L DK++ + + + + E++ +L KE
Sbjct: 1416 EKTKQRLQGEVEDLMVDVERANSLAAAL-DKKQRNFDKVLAEWKTKCEESQAELEASLKE 1474
Query: 84 IQRLRDQL-KARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAEL 142
+ L +L K + + L+QLE RE + EQ + L+E Q++ I EL
Sbjct: 1475 SRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTE-------QIAENGKTIHEL 1527
Query: 143 ESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKI 202
E + L + +IQL ALE+ + L +++ + + ++ L ++
Sbjct: 1528 EKSRKQIELEKA----------------DIQL--ALEEAEAALEHEEAKILRIQLELTQV 1569
Query: 203 -FELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQ---TITQL 258
E+++K + Q + + E Q + + S + + ++++ + ++
Sbjct: 1570 KSEIDRKIAEKDEEIEQLKRNYQR---TVETMQSALDAEVRSRNEAIRLKKKMEGDLNEI 1626
Query: 259 SFELSEFRRKYEETQKEVHNL----------------------NQLLYSQRRADVQHLED 296
+LS R+ ET K + ++ QL +RRA++ E
Sbjct: 1627 EIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAE- 1685
Query: 297 DRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEE-QTRVALLEQQ 355
E+++ E+ + AR E+E S E + + TSL+ +++ +T + L+ +
Sbjct: 1686 ----VEELRATLEQTERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSE 1741
Query: 356 MQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQ 399
++ + D N + + ++ +EL+K ++ LE +K+
Sbjct: 1742 VEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1785
Score = 54.7 bits (130), Expect = 2e-07
Identities = 82/433 (18%), Positives = 162/433 (37%), Gaps = 41/433 (9%)
Query: 20 NSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTE 79
N K+ LEK + +I K + + E ++L L K + ++ E
Sbjct: 1520 NGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAE 1579
Query: 80 KDKEIQRLRDQLKARYSTTALLEQ--LEETTREGERREQVLKALSEEKDVLKQQLSAATS 137
KD+EI+ QLK Y T Q L+ R ++ K + + + ++ QLS A
Sbjct: 1580 KDEEIE----QLKRNYQRTVETMQSALDAEVRSRNEAIRLKKKMEGDLNEIEIQLSHANR 1635
Query: 138 RIAEL---------ESKTNTLRLSQTVA---------------PNCFNSSINNIHEMEIQ 173
+ AE + K L L + N + + + Q
Sbjct: 1636 QAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQ 1695
Query: 174 LKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEK 233
+ A + +Q L+ +R + + +KK ET L + + + EEK
Sbjct: 1696 TERARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEK 1755
Query: 234 QKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQH 293
K A ++L+ E+ T L + ++ Q + QL + +Q
Sbjct: 1756 AKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDEAEQLALKGGKKQIQK 1815
Query: 294 LEDDRHKTE-KIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALL 352
LE + E +++ +++N + L + ++R +EL Q +E++ V L
Sbjct: 1816 LETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQ----------SEEDRKNVLRL 1865
Query: 353 EQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTF 412
+ + + ++ K + Q + L + RKA++++ + E + E + +
Sbjct: 1866 QDLVDKLQVKVKSYKRQAEEADEQANAHLTKFRKAQHELEEAEERADIAESQVNKLRAKT 1925
Query: 413 QGETENREKVAAS 425
+ T +R V S
Sbjct: 1926 RDFTSSRMVVHES 1938
Score = 45.1 bits (105), Expect = 1e-04
Identities = 64/320 (20%), Positives = 137/320 (42%), Gaps = 46/320 (14%)
Query: 70 KEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLK 129
K K + E +KE+ ++++ + ++L ++ + + E+ L L +EK+ L+
Sbjct: 836 KIKPLLKSAETEKEMATMKEEFQKTK------DELAKSEAKRKELEEKLVTLVQEKNDLQ 889
Query: 130 QQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
Q+ A + + + E + + L I ++E ++K+ E+ + +
Sbjct: 890 LQVQAESENLLDAEERCDQL--------------IKAKFQLEAKIKEVTERAEDEEEINA 935
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
+ + L + EL+K + +L K E E + E K K + L+
Sbjct: 936 ELTAKKRKLEDECSELKKDIDDLELTLA----KVEKEKHATENKVKNLTEELSGLD---- 987
Query: 250 VERQTITQLSFELSEFRRKYEET----QKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQ 305
+TI +L+ E + +++ Q E +N L ++ + + Q +ED E+ +
Sbjct: 988 ---ETIAKLTREKKALQEAHQQALDDLQAEEDKVNSLNKTKSKLE-QQVEDLESSLEQEK 1043
Query: 306 KLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFEN 365
KLR + + + KLE + K ++E + L+ ++Q L ++ + C L +
Sbjct: 1044 KLRVDLERNKRKLEGDLKLAQESILD--------LENDKQQLDERLKKKDFEYCQLQSKV 1095
Query: 366 EKLDRQHVQHQLHVILKELR 385
E D Q + Q +KEL+
Sbjct: 1096 E--DEQTLGLQFQKKIKELQ 1113
>gi|115527082 myosin, heavy chain 1, skeletal muscle, adult [Homo
sapiens]
Length = 1939
Score = 67.8 bits (164), Expect = 2e-11
Identities = 97/452 (21%), Positives = 187/452 (41%), Gaps = 48/452 (10%)
Query: 10 IKSKWGSKPSNSKSET--------TLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLE 61
+K K + S K E T+ K KG + + ++++ S + K ++E+ RL+
Sbjct: 1217 VKQKLEKEKSEMKMEIDDLASNMETVSKAKGNLEKMCRALEDQLS-EIKTKEEEQQRLIN 1275
Query: 62 KIRV----LEAEKEKNAYQLTEKDKEIQRL-RDQLKARYSTTALLEQLEETTREGERREQ 116
+ L+ E + + QL EKD + +L R + L QLEE +
Sbjct: 1276 DLTAQRARLQTESGEYSRQLDEKDTLVSQLSRGKQAFTQQIEELKRQLEEEIKAKSALAH 1335
Query: 117 VLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKD 176
L++ + D+L++Q AEL+ + + + VA + I E +L++
Sbjct: 1336 ALQSSRHDCDLLREQYEEEQEAKAELQRAMS--KANSEVAQWRTKYETDAIQRTE-ELEE 1392
Query: 177 ALEKNQQWLVYDQQREVYVKGLLAKIFELEK---KTETAAHSLPQQTKKPESEGYLQEEK 233
A +K Q L Q E +V+ + AK LEK + + L ++ + ++K
Sbjct: 1393 AKKKLAQRL---QDAEEHVEAVNAKCASLEKTKQRLQNEVEDLMIDVERTNAACAALDKK 1449
Query: 234 QKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQH 293
Q+ ++ +LA K+ E E + E +QKE +L+ L+ + A +
Sbjct: 1450 QRNFDKILAEWKQKCE--------------ETHAELEASQKESRSLSTELFKIKNAYEES 1495
Query: 294 LEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLE 353
L+ + + L++E ++ E KR EL +K+Q EQ + + L+
Sbjct: 1496 LDQLETLKRENKNLQQEISDLTEQIAEGGKRIHEL---------EKIKKQVEQEK-SELQ 1545
Query: 354 QQMQACTLDFENEKLDRQHVQHQLHVILKEL-RKARNQITQLESLKQLHEFAITEPLVTF 412
++ E+E+ +Q +L+ + E+ RK + +++ +K+ H + T
Sbjct: 1546 AALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEIDQMKRNHIRIVESMQSTL 1605
Query: 413 QGETENREKVAASPKSPTAALNESLVECPKCN 444
E +R K LNE ++ N
Sbjct: 1606 DAEIRSRNDAIRLKKKMEGDLNEMEIQLNHAN 1637
Score = 50.8 bits (120), Expect = 3e-06
Identities = 88/430 (20%), Positives = 170/430 (39%), Gaps = 65/430 (15%)
Query: 8 DLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLE 67
+L K K + S+ + LE+ + + H + + I ++ + ++ EK ++
Sbjct: 1529 ELEKIKKQVEQEKSELQAALEEAEASLEHEEGKILRIQLELNQVKSEVDRKIAEKDEEID 1588
Query: 68 AEKEKNAYQLTEK-----DKEIQRLRDQLKARYSTTALLEQLE-----------ETTREG 111
K +N ++ E D EI+ D ++ + L ++E E R
Sbjct: 1589 QMK-RNHIRIVESMQSTLDAEIRSRNDAIRLKKKMEGDLNEMEIQLNHANRMAAEALRNY 1647
Query: 112 ERREQVLK--------ALSEEKDVLKQQLSAATSRIAELESKTNTLR--LSQTVAPNCFN 161
+ +LK AL ++D LK+QL+ R L+++ LR L QT
Sbjct: 1648 RNTQAILKDTQLHLDDALRSQED-LKEQLAMVERRANLLQAEIEELRATLEQT------- 1699
Query: 162 SSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTK 221
I E E L DA E+ Q L++ Q + +KK ET + + +
Sbjct: 1700 ERSRKIAEQE--LLDASERVQ--LLHTQN---------TSLINTKKKLETDISQIQGEME 1746
Query: 222 KPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQ 281
E EEK K A ++L+ E+ T S L ++ E+T K++
Sbjct: 1747 DIIQEARNAEEKAKKAITDAAMMAEELKKEQDT----SAHLERMKKNLEQTVKDL----- 1797
Query: 282 LLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEE----LLSQVQFLYT 337
Q R D + ++IQKL G++E E+KR+ E L + +
Sbjct: 1798 ----QHRLDEAEQLALKGGKKQIQKLEARVRELEGEVESEQKRNVEAVKGLRKHERKVKE 1853
Query: 338 SLLKQQEEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESL 397
+ +E++ + L+ + ++ K + + Q +V L + R+ ++++ + E
Sbjct: 1854 LTYQTEEDRKNILRLQDLVDKLQAKVKSYKRQAEEAEEQSNVNLSKFRRIQHELEEAEER 1913
Query: 398 KQLHEFAITE 407
+ E + +
Sbjct: 1914 ADIAESQVNK 1923
Score = 50.1 bits (118), Expect = 4e-06
Identities = 66/350 (18%), Positives = 148/350 (42%), Gaps = 58/350 (16%)
Query: 70 KEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLK 129
K K + E +KE+ ++++ + E+L +T + + E+ + L +EK+ L+
Sbjct: 839 KIKPLLKSAETEKEMANMKEEFEKTK------EELAKTEAKRKELEEKMVTLMQEKNDLQ 892
Query: 130 QQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWLVYDQ 189
Q+ A +A+ E + + L I ++E ++K+ E+ + +
Sbjct: 893 LQVQAEADSLADAEERCDQL--------------IKTKIQLEAKIKEVTERAEDEEEINA 938
Query: 190 QREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLE 249
+ + L + EL+K + L K E E + E K K + +A
Sbjct: 939 ELTAKKRKLEDECSELKKDID----DLELTLAKVEKEKHATENKVKNLTEEMAGLD---- 990
Query: 250 VERQTITQLSFELSEFRRKYEET----QKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQ 305
+TI +L+ E + +++T Q E +N L ++ + + Q ++D E+ +
Sbjct: 991 ---ETIAKLTKEKKALQEAHQQTLDDLQAEEDKVNTLTKAKIKLE-QQVDDLEGSLEQEK 1046
Query: 306 KLREENDIARGKL--------------EEEKKRSEELLSQVQFLYTSLLKQQEE------ 345
K+R + + A+ KL E +K++ +E L + +F + L + E+
Sbjct: 1047 KIRMDLERAKRKLEGDLKLAQESTMDIENDKQQLDEKLKKKEFEMSGLQSKIEDEQALGM 1106
Query: 346 --QTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQ 393
Q ++ L+ +++ + E E+ R + Q + +EL + ++ +
Sbjct: 1107 QLQKKIKELQARIEELEEEIEAERASRAKAEKQRSDLSRELEEISERLEE 1156
Score = 50.1 bits (118), Expect = 4e-06
Identities = 79/399 (19%), Positives = 169/399 (42%), Gaps = 52/399 (13%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKGKLTDKER----------------HRLLE----KI 63
E T ++L+ E+ L V+ + L K+R H LE +
Sbjct: 1419 EKTKQRLQNEVEDLMIDVERTNAACAALDKKQRNFDKILAEWKQKCEETHAELEASQKES 1478
Query: 64 RVLEAE--KEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKAL 121
R L E K KNAY+ + E + R+ + + L EQ+ E + E++ K +
Sbjct: 1479 RSLSTELFKIKNAYEESLDQLETLK-RENKNLQQEISDLTEQIAEGGKRIHELEKIKKQV 1537
Query: 122 SEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKN 181
+EK L+ L A + + E K ++L +N + + E+ K A EK+
Sbjct: 1538 EQEKSELQAALEEAEASLEHEEGKILRIQL-----------ELNQV-KSEVDRKIA-EKD 1584
Query: 182 QQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLL 241
++ DQ + +++ + + L+ + + ++ + KK E + E + N +
Sbjct: 1585 EE---IDQMKRNHIRIVESMQSTLDAEIRSRNDAI-RLKKKMEGDLNEMEIQLNHANRMA 1640
Query: 242 ASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKT 301
A A ++ + + L + R E+ ++ QL +RRA++ E
Sbjct: 1641 AEALRNYRNTQAILKDTQLHLDDALRSQEDLKE------QLAMVERRANLLQAE-----I 1689
Query: 302 EKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEE-QTRVALLEQQMQACT 360
E+++ E+ + +R E+E + E + + TSL+ +++ +T ++ ++ +M+
Sbjct: 1690 EELRATLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLETDISQIQGEMEDII 1749
Query: 361 LDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQ 399
+ N + + ++ +EL+K ++ LE +K+
Sbjct: 1750 QEARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKK 1788
>gi|31563507 GRIP and coiled-coil domain-containing 2 [Homo sapiens]
Length = 1684
Score = 67.4 bits (163), Expect = 3e-11
Identities = 106/472 (22%), Positives = 198/472 (41%), Gaps = 64/472 (13%)
Query: 27 LEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTE---KDKE 83
+EKLK E+A L K E+H +++ L+ + +K +L E D E
Sbjct: 401 IEKLKSELAGLN---------KQFCYTVEQHN--REVQSLKEQHQKEISELNETFLSDSE 449
Query: 84 IQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIA--- 140
+++L + L EQ E +E + ++L E ++L+ +L + +I+
Sbjct: 450 ----KEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEF 505
Query: 141 ------------ELESKTNTLRLSQTVAPNCFN----------SSINNIHEMEIQLKDAL 178
EL+ K T + N S + E+E +K+
Sbjct: 506 ESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQ 565
Query: 179 EKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYN 238
EKN +L+ QR+ +K L KI L ++ + + L ++ ++ E +++
Sbjct: 566 EKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREER--- 622
Query: 239 DLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDR 298
L+ K +E Q ++L +++E EET KE +Q L + ++ L +D+
Sbjct: 623 -LILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKL-EKLMVQMKVLSEDK 680
Query: 299 H-KTEKIQKLREENDIARGKLEEEKKR----SEELLSQVQFLYTSLLKQQEEQTRVALLE 353
+ +++ L EEN+ KL EKK+ E LSQ + + Q E+ ++E
Sbjct: 681 EVLSAEVKSLYEENN----KLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVE 736
Query: 354 QQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQ 413
+Q L ENE++ + V+ QL+ LKE+ ++ ++ + + + + A+ E L
Sbjct: 737 EQDNLNKL-LENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQ-AVGESLAKIN 794
Query: 414 GET-----ENREKVAASPKSPTAALNESLVECPKCNIQYPATEHRDLLVHVE 460
E + EKV K ES+V+C + E +L+ E
Sbjct: 795 EEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKE 846
Score = 63.5 bits (153), Expect = 4e-10
Identities = 82/361 (22%), Positives = 166/361 (45%), Gaps = 40/361 (11%)
Query: 61 EKIRVLEAEKEKNAYQLTEK----DKEIQRLRDQLKARYSTTALLEQLEETTREGERREQ 116
E + + EK A+Q EK +KEI+ L+++ + E+L+ R+ E+ +
Sbjct: 788 ESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEE------SVVQCEELKSLLRDYEQEKV 841
Query: 117 VLKALSEEKDVLKQQLSAATSRIAELESKT-----NTLRLSQTVAPNCFNSSINN----- 166
+L+ EE K+ L + + KT N L + V+ C S I+N
Sbjct: 842 LLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKC 901
Query: 167 -IHEMEIQLKDALEKNQQWLVYDQQRE-VYVKGLLAKIFELEKKTETAAHSLPQQTKKPE 224
I E E LK LE+ + + D++ E + +K LAK ++ ++ L ++ + E
Sbjct: 902 FIKEHE-NLKPLLEQKE---LRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLE 957
Query: 225 SEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNL----- 279
E +EEK + AKK+L+ R+ + EL R + ++ + +L
Sbjct: 958 KECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAE 1017
Query: 280 ---NQLLYSQRRADVQHLEDDRHKT--EKIQKLREENDIARGKLEEEKKRSEELLSQVQF 334
N LL +++++ +E +R +I+ L + + + E +E+LL++++
Sbjct: 1018 SYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIET 1077
Query: 335 LYTS--LLKQQ--EEQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQ 390
L ++ LL+ Q E Q A+++++++A L E + + ++L + +L+K + Q
Sbjct: 1078 LQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKEKKQ 1137
Query: 391 I 391
+
Sbjct: 1138 L 1138
Score = 51.6 bits (122), Expect = 1e-06
Identities = 86/378 (22%), Positives = 161/378 (42%), Gaps = 57/378 (15%)
Query: 46 SGKGKLTDKERHRLLE--KIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYS---TTAL 100
+GK KL + L++ K +++ +K K+ + TE +KEI+ LR + + AL
Sbjct: 17 TGKSKLETLPKEDLIKFAKKQMMLIQKAKS--RCTELEKEIEELRSKPVTEGTGDIIKAL 74
Query: 101 LEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCF 160
E+L+ E EQ +L +E +KQ++ + +++ + +
Sbjct: 75 TERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELE------------- 121
Query: 161 NSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTE-TAAHSLPQQ 219
S IN + E+E KN+ V + E K L K E T+ + L Q
Sbjct: 122 QSHINYVKEIENL------KNELMAVRSKYSE--DKANLQKQLEEAMNTQLELSEQLKFQ 173
Query: 220 TKKPESEGYLQEEKQKC---YNDLLASAKKDLEV----ERQTITQLSFELSEFRRKYEET 272
++ LQEE +K + + + +K L+ +++T+TQL + + Y++
Sbjct: 174 NNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQK- 232
Query: 273 QKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQKLREENDIARGKLEEEK----KRSEEL 328
N+N L + H E+ + +I+ +E++ KL E K K+ E
Sbjct: 233 -----NINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEAS 287
Query: 329 LSQVQFLYTSLLKQQEEQTRVALLEQQMQACTLDFEN----EKLDRQHVQHQLHVILKEL 384
+Q Y L+ + T A Q Q C++ + E++ + V+H L LKEL
Sbjct: 288 EKNIQKKYECELENLRKATSNA--NQDNQICSILLQENTFVEQVVNEKVKH-LEDTLKEL 344
Query: 385 RK----ARNQITQLESLK 398
++++T + +LK
Sbjct: 345 ESQHSILKDEVTYMNNLK 362
Score = 50.8 bits (120), Expect = 3e-06
Identities = 101/487 (20%), Positives = 199/487 (40%), Gaps = 62/487 (12%)
Query: 22 KSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRL--LEKIRVLEAEKEKNAYQL-T 78
K++ L+ + E +K ++ + S K +L+ R + E + L E EK + QL
Sbjct: 976 KAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDV 1035
Query: 79 EKDKEIQ---RLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAA 135
EK++ R+ D + ++T E + + R + L++ ++ +V ++ A
Sbjct: 1036 EKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRA 1095
Query: 136 TSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQL---KDALEKNQQWLVY---DQ 189
+ + + E + L+ Q + + +++N + E+++QL K L+K Q L D
Sbjct: 1096 KAMV-DKELEAEKLQKEQKIKEHA--TTVNELEELQVQLQKEKKQLQKTMQELELVKKDA 1152
Query: 190 QR-----------EVYVKGLLAKIFELEKKTETAAHSLPQQTKKPE----------SEGY 228
Q+ E +K L K+ K E + Q +K E S
Sbjct: 1153 QQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQ 1212
Query: 229 LQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLN-QL--LYS 285
EEK LL KK+L +Q T + + + E +Q++V QL + S
Sbjct: 1213 QYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITS 1272
Query: 286 QRRADVQHLED--DRHK------TEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYT 337
++ +HL+ ++H+ +++ L+EE A+ + E +V
Sbjct: 1273 EKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVH---- 1328
Query: 338 SLLKQQE----EQTRVALLEQQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQ-IT 392
++LKQQ+ Q +Q+ + + + K+ Q Q+ L + + EL+ +++ T
Sbjct: 1329 NVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDT 1388
Query: 393 QLESLKQL------HEFAITEPLVTFQGETENREKVAASPKSPTAALNESLVECPKCNIQ 446
LE ++ E + E L + Q E + S + NE L + ++
Sbjct: 1389 LLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVR 1448
Query: 447 YPATEHR 453
+ EHR
Sbjct: 1449 HLQEEHR 1455
>gi|116256481 TNFAIP3 interacting protein 1 [Homo sapiens]
Length = 636
Score = 67.0 bits (162), Expect = 3e-11
Identities = 82/349 (23%), Positives = 144/349 (41%), Gaps = 59/349 (16%)
Query: 83 EIQRLRDQLKARYSTTALLEQLEETTREG------------ERREQVLKALSEEKDVLKQ 130
E RL ++ T++L+ L E R+ E+R+Q + L EE LK+
Sbjct: 190 EFNRLASKVHKNEQRTSILQTLCEQLRKENEALKAKLDKGLEQRDQAAERLREENLELKK 249
Query: 131 QLSA-----------------ATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQ 173
L + T + A + ++ + ++ + +E Q
Sbjct: 250 LLMSNGNKEGASGRPGSPKMEGTGKKAVAGQQQASVTAGKVPEVVALGAAEKKVKMLEQQ 309
Query: 174 LKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEK 233
+ LE N+QW DQ + KI EL +K L +Q E+E +E+K
Sbjct: 310 RSELLEVNKQW---DQHFRSMKQQYEQKITELRQKLA----DLQKQVTDLEAE---REQK 359
Query: 234 QKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQH 293
Q+ ++ L AK +E+E QL+ E E R+K + Q ++ L + Q + ++Q
Sbjct: 360 QRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVKYLQDQLSPLTRQREYQEK-EIQR 418
Query: 294 LEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTRVALLE 353
L + IQ A G E +LL++QE T+ LL+
Sbjct: 419 LNKALEEALSIQTPPSSPPTAFGSPEGAG---------------ALLRKQELVTQNELLK 463
Query: 354 QQMQACTLDFENEKLDRQHVQHQLHVILKELRKARNQIT----QLESLK 398
QQ++ DF+ E+ DR+ + + + K++ K + Q+T QL++ K
Sbjct: 464 QQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFK 512
Score = 38.9 bits (89), Expect = 0.010
Identities = 55/217 (25%), Positives = 100/217 (46%), Gaps = 29/217 (13%)
Query: 24 ETTLEKLKGEIAHLKTSVDEITSGKG-KLTDKERHRLL--EKIRVLEAEKEKNAYQLTEK 80
E + +L+ ++A L+ V ++ + + K D +R LL KI + E +KE QLT +
Sbjct: 332 EQKITELRQKLADLQKQVTDLEAEREQKQRDFDRKLLLAKSKIEMEETDKE----QLTAE 387
Query: 81 DKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALS---EEKDVLKQQLSAATS 137
KE+++ K +Y L +QL TR+ E +E+ ++ L+ EE ++ S+ +
Sbjct: 388 AKELRQ-----KVKY----LQDQLSPLTRQREYQEKEIQRLNKALEEALSIQTPPSSPPT 438
Query: 138 RIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQL----KDALEKNQQWL---VYDQQ 190
E LR + V N I E + Q ++ + + ++ L V Q
Sbjct: 439 AFGSPEGAGALLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQ 498
Query: 191 REVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEG 227
+V + K F+ E+K A +L QQ +K ++ G
Sbjct: 499 AQVTLSNAQLKAFKDEEK---AREALRQQKRKAKASG 532
Score = 29.3 bits (64), Expect = 7.9
Identities = 18/59 (30%), Positives = 32/59 (54%), Gaps = 3/59 (5%)
Query: 55 ERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGER 113
+R R+ E+ L+ + EK Q+T + +++ +D+ KAR AL +Q + GER
Sbjct: 479 DRERMNEEKEELKKQVEKLQAQVTLSNAQLKAFKDEEKAR---EALRQQKRKAKASGER 534
>gi|64085252 hypothetical protein LOC145508 [Homo sapiens]
Length = 1094
Score = 67.0 bits (162), Expect = 3e-11
Identities = 99/432 (22%), Positives = 176/432 (40%), Gaps = 69/432 (15%)
Query: 31 KGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEIQRLRDQ 90
+ E H + E+T T K+ R L +++ EA KE+ EK +E +L+ Q
Sbjct: 434 EAERKHADLQISELTRHAEDAT-KQAERYLSELQQSEALKEE-----AEKRREDLKLKAQ 487
Query: 91 -------LKARYSTTALLEQLEETTREGERREQVLKALSEEKDVLKQQLSAATSRIAELE 143
LK + AL +Q E + Q+LK EKD LK QL AA +I L
Sbjct: 488 ESIRQWKLKHKKLERALEKQSETVDELTGKNNQILK----EKDELKTQLYAALQQIENLR 543
Query: 144 SKTNTLRLSQTVAPNCFNS---------------------SINNIHEMEIQLKDALEKNQ 182
+ N + + + +S S++ IH +E +LK +
Sbjct: 544 KELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSKIQS 603
Query: 183 QWLVYDQQREVYVKGLL-------AKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQK 235
Q V E + L AK+ E+++ + + K E ++ K
Sbjct: 604 QMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKAVLK 663
Query: 236 CYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLE 295
+DL A AK E ITQL E +R+ ++ + ++ + ++H +
Sbjct: 664 DLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHFK 723
Query: 296 DDRHKTE------KIQKLREEN--DIARGKLEEEKKRSEELLSQ----------VQFLYT 337
++ + E K + L E+N I RG+LE+ K + + L + ++ Y
Sbjct: 724 KEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKYQ 783
Query: 338 SLLKQQEEQTRVALLEQQ----MQACTLDFENEKLDRQHVQHQ-LHVILKELRKARNQIT 392
L Q EE+ + +E++ M+ L +++ L + Q L VI KE+ A +
Sbjct: 784 CLKDQLEEREKHISIEEEHLRRMEEARLQLKDQLLCLETEQESILGVIGKEIDAACKTFS 843
Query: 393 QLESLKQLHEFA 404
+ +S+++L F+
Sbjct: 844 K-DSVEKLKVFS 854
Score = 53.5 bits (127), Expect = 4e-07
Identities = 93/435 (21%), Positives = 187/435 (42%), Gaps = 57/435 (13%)
Query: 25 TTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVLEAEKEKNAYQLTEKDKEI 84
T L K +G+ L+ V +I+ + D++ + R +E EK+ + +K++
Sbjct: 314 TQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFR-RGVEREKQ-------DLEKQM 365
Query: 85 QRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEKDVL--------KQQLSAAT 136
LR QL + +A+ +LEE R ER+++ L+ + + L KQQL
Sbjct: 366 SDLRVQL----NFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENGEKQQLQ-ML 420
Query: 137 SRIAELESKTNT---------LRLSQTV--APNCFNSSINNIHEMEIQ--LKDALEKNQQ 183
R+ E+++ +T L++S+ A + + + E++ LK+ EK ++
Sbjct: 421 DRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQSEALKEEAEKRRE 480
Query: 184 WLVYDQQREVYVKGLLAKIFE--LEKKTETAAHSLPQQTKKPESEGYLQ----------E 231
L Q + L K E LEK++ET + + + + L+ E
Sbjct: 481 DLKLKAQESIRQWKLKHKKLERALEKQSETVDELTGKNNQILKEKDELKTQLYAALQQIE 540
Query: 232 EKQKCYNDLL---ASAKKDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRR 288
+K ND+L A +++L + + + + ++ + + + +H L L Q +
Sbjct: 541 NLRKELNDVLTKRALQEEELHSKEEKLRDIKSHQADLELEVKNSLDTIHRLESELKKQSK 600
Query: 289 ADVQHLEDDRHKTEKIQKLREENDIARGKLEEEKKRSEELLSQVQFLYTSLLKQQEEQTR 348
Q + H E+I +L++ + KL E ++ ++L + L L +++ +
Sbjct: 601 IQSQMKVEKAHLEEEIAELKKSQAQDKAKLLEMQESIKDLSAIRADLANKLAEEERAKKA 660
Query: 349 VA--LLEQQMQACTLDFENEKLDRQ-HVQHQLHVILKELRKARNQITQLESLKQLHEFAI 405
V L + QA + D E + Q ++ +H R+ ++ + L+S+K HE I
Sbjct: 661 VLKDLSDLTAQAKSRDEETATIITQLKLERDVH-----QRELKDLTSSLQSVKTKHEQNI 715
Query: 406 TEPLVTFQGETENRE 420
E + F+ E E
Sbjct: 716 QELMKHFKKEKSEAE 730
Score = 40.0 bits (92), Expect = 0.004
Identities = 64/307 (20%), Positives = 127/307 (41%), Gaps = 43/307 (14%)
Query: 160 FNSSINNIHEMEIQLKDALEKNQQWLVYDQQREVYVKGLLAKIFELEKKTETAAH----- 214
FN ++ + + K ALE+ + L Q++EV + ++ ELE++ T
Sbjct: 182 FNRELSRRSRSDAETKRALEELTEKLNEAQKQEVVSDRVERRLQELEREMRTERELVERR 241
Query: 215 --SLPQQTKKPESEGYLQEEKQKCYNDLLASAKKDLEVERQTITQLSFELSEFRRKYEET 272
L + + + QE K + + + + E E+ + Q ELS E
Sbjct: 242 QDQLGLMSLQLQEALKKQEAKADEHEGAIKNKLRQTETEKNQLEQ-ELELSRRLLNQSEG 300
Query: 273 QKE--VHNLNQLLYSQRRADVQHLEDDR----HKTEKIQKLREENDIARGK-------LE 319
+E +H + +L R + E DR H+ +I K + +G+ +E
Sbjct: 301 SRETLLHQVEEL-----RTQLTKAEGDRKGLQHQVSQISKQQSNYQDEQGEDWRFRRGVE 355
Query: 320 EEKKRSEELLS--QVQFLYTSLLKQQEEQTRV--------ALLEQQMQACTLDFENEKLD 369
EK+ E+ +S +VQ ++++ + EE R A L Q++ T + EN +
Sbjct: 356 REKQDLEKQMSDLRVQLNFSAMASELEEVKRCMERKDKEKAHLASQVENLTRELENG--E 413
Query: 370 RQHVQHQLHVILKELRKARNQITQLESLKQLHEFAITEPLVTFQGETENREKVAASPKSP 429
+Q +Q +L L++ +N E+ ++ + I+E + T+ E+ + +
Sbjct: 414 KQQLQ-----MLDRLKEIQNHFDTCEAERKHADLQISELTRHAEDATKQAERYLSELQQS 468
Query: 430 TAALNES 436
A E+
Sbjct: 469 EALKEEA 475
Score = 36.2 bits (82), Expect = 0.065
Identities = 64/323 (19%), Positives = 127/323 (39%), Gaps = 38/323 (11%)
Query: 7 KDLIKSKWGSKPSNSKSETTLEKLKGEIAHLKTSVDEITSGKGKLTDKERHRLLEKIRVL 66
KDL +K + ++ T + +LK E + + ++TS + K + E ++
Sbjct: 663 KDLSDLTAQAKSRDEETATIITQLKLERDVHQRELKDLTSSLQSVKTKHEQNIQELMKHF 722
Query: 67 EAEK-EKNAYQLTEKDKEIQRLRDQLKARYSTTALLEQLEETTREGERREQVLKALSEEK 125
+ EK E + T K + ++ R L Q + T E + E K L +
Sbjct: 723 KKEKSEAENHIRTLKAESLEEKNMAKIHRGQLEKLKSQCDRLTEELTQNENENKKLKLKY 782
Query: 126 DVLKQQLSAATSRIAELESKTNTLRLSQTVAPNCFNSSINNIHEMEIQLKDALEKNQQWL 185
LK QL I+ E + + E +QLKD Q L
Sbjct: 783 QCLKDQLEEREKHISIEE------------------EHLRRMEEARLQLKD------QLL 818
Query: 186 VYDQQREVYVKGLLAKIFELEKKTETAAHSLPQQTKKPESEGYLQEEKQKCYNDLLASAK 245
+ ++E + G++ K E++ +T + ++ K S + + + LA +K
Sbjct: 819 CLETEQE-SILGVIGK--EIDAACKTFSKDSVEKLKVFSSGPDIHYDPHR----WLAESK 871
Query: 246 KDLEVERQTITQLSFELSEFRRKYEETQKEVHNLNQLLYSQRRADVQHLEDDRHKTEKIQ 305
L+ + + + R + ++++ NL + S+ + Q +E ++I
Sbjct: 872 TKLQWLCEELKERENREKNLRHQLMLCRQQLRNLTENKESELQCLFQQIERQEQLLDEIH 931
Query: 306 KLREENDIARGKLEEEKKRSEEL 328
RE+ D+ LEE +++ EE+
Sbjct: 932 --REKRDL----LEETQRKDEEM 948
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.329
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,951,192
Number of Sequences: 37866
Number of extensions: 713506
Number of successful extensions: 9380
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 234
Number of HSP's successfully gapped in prelim test: 955
Number of HSP's that attempted gapping in prelim test: 4450
Number of HSP's gapped (non-prelim): 3356
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.