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Search of human proteins with 187607323
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187607323 eukaryotic translation initiation factor 2B,
subunit 4 delta isoform 1 [Homo sapiens]
(543 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187607323 eukaryotic translation initiation factor 2B, subuni... 1065 0.0
gi|78000156 eukaryotic translation initiation factor 2B, subunit... 1004 0.0
gi|78000158 eukaryotic translation initiation factor 2B, subunit... 1000 0.0
gi|4503503 eukaryotic translation initiation factor 2B, subunit ... 104 2e-22
gi|7657058 eukaryotic translation initiation factor 2B, subunit ... 87 4e-17
gi|72534748 translation initiation factor eIF-2B subunit alpha/b... 69 1e-11
gi|23943880 translation initiation factor eIF-2B subunit alpha/b... 65 2e-10
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 47 4e-05
gi|157785645 SPEG complex locus [Homo sapiens] 42 0.001
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 41 0.002
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 41 0.003
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 41 0.003
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 41 0.003
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 41 0.003
gi|11067749 bromodomain containing protein 3 [Homo sapiens] 41 0.003
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 40 0.004
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 40 0.004
gi|24308289 leukocyte receptor cluster (LRC) member 1 [Homo sapi... 40 0.005
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 40 0.007
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 40 0.007
gi|217035154 RCSD domain containing 1 [Homo sapiens] 39 0.009
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 39 0.016
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 38 0.021
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 38 0.021
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 38 0.021
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 38 0.021
gi|125656165 THO complex 2 [Homo sapiens] 38 0.027
gi|21361517 UBX domain protein 1 [Homo sapiens] 38 0.027
gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens] 37 0.035
gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo... 37 0.035
>gi|187607323 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 1 [Homo sapiens]
Length = 543
Score = 1065 bits (2755), Expect = 0.0
Identities = 543/543 (100%), Positives = 543/543 (100%)
Query: 1 MPTQQPAAPSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQL 60
MPTQQPAAPSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQL
Sbjct: 1 MPTQQPAAPSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQL 60
Query: 61 RKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAEL 120
RKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAEL
Sbjct: 61 RKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAEL 120
Query: 121 RAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVK 180
RAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVK
Sbjct: 121 RAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVK 180
Query: 181 KPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVS 240
KPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVS
Sbjct: 181 KPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHPAMVRLGLQYSQGLVS 240
Query: 241 GSNARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFL 300
GSNARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFL
Sbjct: 241 GSNARCIALLRALQQVIQDYTTPPNEELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFL 300
Query: 301 NKEITSVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSS 360
NKEITSVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSS
Sbjct: 301 NKEITSVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQKISNGDVILVYGCSS 360
Query: 361 LVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSK 420
LVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSK
Sbjct: 361 LVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSK 420
Query: 421 VLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDP 480
VLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDP
Sbjct: 421 VLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDP 480
Query: 481 DDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKS 540
DDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKS
Sbjct: 481 DDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELGMIPCSSVPVVLRVKS 540
Query: 541 SDQ 543
SDQ
Sbjct: 541 SDQ 543
>gi|78000156 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 3 [Homo sapiens]
Length = 522
Score = 1004 bits (2597), Expect = 0.0
Identities = 512/512 (100%), Positives = 512/512 (100%)
Query: 32 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ 91
DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ
Sbjct: 11 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ 70
Query: 92 GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP 151
GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP
Sbjct: 71 GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP 130
Query: 152 STAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNS 211
STAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNS
Sbjct: 131 STAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNS 190
Query: 212 LTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRD 271
LTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRD
Sbjct: 191 LTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSRD 250
Query: 272 LVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEK 331
LVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEK
Sbjct: 251 LVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEK 310
Query: 332 IVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRH 391
IVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRH
Sbjct: 311 IVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRH 370
Query: 392 TLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHN 451
TLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHN
Sbjct: 371 TLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHN 430
Query: 452 VPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDV 511
VPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDV
Sbjct: 431 VPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDV 490
Query: 512 TPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 543
TPPELVDLVITELGMIPCSSVPVVLRVKSSDQ
Sbjct: 491 TPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 522
>gi|78000158 eukaryotic translation initiation factor 2B, subunit 4
delta isoform 2 [Homo sapiens]
Length = 523
Score = 1000 bits (2585), Expect = 0.0
Identities = 512/513 (99%), Positives = 512/513 (99%), Gaps = 1/513 (0%)
Query: 32 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ 91
DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ
Sbjct: 11 DSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ 70
Query: 92 -GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKAS 150
GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKAS
Sbjct: 71 VGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKAS 130
Query: 151 PSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQN 210
PSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQN
Sbjct: 131 PSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQN 190
Query: 211 SLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSR 270
SLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSR
Sbjct: 191 SLTQFMSIPSSVIHPAMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPNEELSR 250
Query: 271 DLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQE 330
DLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQE
Sbjct: 251 DLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQE 310
Query: 331 KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGR 390
KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGR
Sbjct: 311 KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGR 370
Query: 391 HTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAH 450
HTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAH
Sbjct: 371 HTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAH 430
Query: 451 NVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYD 510
NVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYD
Sbjct: 431 NVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYD 490
Query: 511 VTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 543
VTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ
Sbjct: 491 VTPPELVDLVITELGMIPCSSVPVVLRVKSSDQ 523
>gi|4503503 eukaryotic translation initiation factor 2B, subunit 1
alpha, 26kDa [Homo sapiens]
Length = 305
Score = 104 bits (259), Expect = 2e-22
Identities = 63/202 (31%), Positives = 107/202 (52%), Gaps = 8/202 (3%)
Query: 331 KIVLAAQAISRFAYQKISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGR 390
+I L+ I+ + I +G IL + S +V R+L+ A +RF V V +S+P L G+
Sbjct: 103 RISLSRNKIADLCHTFIKDGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLSGK 162
Query: 391 HTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAH 450
++L H VP + +L A Y++ + V++GA ++ NG +++++GT Q+A+ A+A
Sbjct: 163 KMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGVVENGGIINKIGTNQMAVCAKAQ 222
Query: 451 NVPVLVCCETYKFCERVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYD 510
N P V E++KF F N+ D PD + K L Q L+ + D
Sbjct: 223 NKPFYVVAESFKFVR-----LFPLNQQDVPDKFKYKAD---TLKVAQTGQDLKEEHPWVD 274
Query: 511 VTPPELVDLVITELGMIPCSSV 532
T P L+ L+ T+LG++ S+V
Sbjct: 275 YTAPSLITLLFTDLGVLTPSAV 296
>gi|7657058 eukaryotic translation initiation factor 2B, subunit 2
beta, 39kDa [Homo sapiens]
Length = 351
Score = 87.0 bits (214), Expect = 4e-17
Identities = 64/230 (27%), Positives = 114/230 (49%), Gaps = 13/230 (5%)
Query: 300 LNKEITSVGSSKREEEAKSELRAAIDRYVQEKIVL---AAQAISRFAYQKISNGDVILVY 356
L+K +TS G ++ ++L++ I + E +V + I+ A + I + +VI+
Sbjct: 109 LHKLLTSGGLNEDFSFHYAQLQSNIIEAINELLVELEGTMENIAAQALEHIHSNEVIMTI 168
Query: 357 GCSSLVSRILQEAWTEGRRFRVVVVDSRPWLEGRHTLRSLVHAGVPASYLLIPAASYVLP 416
G S V L+EA R+F V+V + P+ +G +L AG+ + + A V+
Sbjct: 169 GFSRTVEAFLKEA-ARKRKFHVIVAECAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMS 227
Query: 417 EVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNE 476
V+KV++G +LANG++ + GT LAL A+ H+ P++VC +K + + ++
Sbjct: 228 RVNKVIIGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKLSPQFPNEEDSFHK 287
Query: 477 LDDPDD-LQCKRGEHVALANWQNHASLRLLNLVYDVTPPELVDLVITELG 525
P++ L G+ L H V+D PPEL+ L I+ +G
Sbjct: 288 FVAPEEVLPFTEGD--ILEKVSVHCP------VFDYVPPELITLFISNIG 329
>gi|72534748 translation initiation factor eIF-2B subunit
alpha/beta/delta-like protein isoform 1 [Homo sapiens]
Length = 369
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/285 (24%), Positives = 130/285 (45%), Gaps = 46/285 (16%)
Query: 272 LVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEITSVGSSKREEEAKSELRAAIDRYVQEK 331
LV ++ +SFL RP + +M A + ++ V + + E E +E V+E+
Sbjct: 75 LVAFVRDKLSFLVTARPTAVNMARAAR----DLADVAAREAEREGATE------EAVRER 124
Query: 332 IVLAAQAI---------------SRFAYQKI--SNGDVILVYGCSS---------LVSRI 365
++ + + +R +++ S G V ++ C++ +
Sbjct: 125 VICCTEDMLEKDLRDNRSIGDLGARHLLERVAPSGGKVTVLTHCNTGALATAGYGTALGV 184
Query: 366 LQEAWTEGRRFRVVVVDSRPWLEG-RHTLRSLVHAGVPASYLL--IPAASYVLPEVSKVL 422
++ + GR ++RP+ +G R T LV+ +PA+ + + AA+ VS V+
Sbjct: 185 IRSLHSLGRLEHAFCTETRPYNQGARLTAFELVYEQIPATLITDSMVAAAMAHRGVSAVV 244
Query: 423 LGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFVSNELDDPDD 482
+GA ++ANG ++VGT QLA+VA+ H +P V + R++T + E +
Sbjct: 245 VGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEIIIEERPGQE 304
Query: 483 LQCKRGEHVALANWQNHASLRLLNLVYDVTPPELV-DLVITELGM 526
L G +A + + N +DVTP +L+ +ITELG+
Sbjct: 305 LTDVNGVRIAA------PGIGVWNPAFDVTPHDLITGGIITELGV 343
>gi|23943880 translation initiation factor eIF-2B subunit
alpha/beta/delta-like protein isoform 2 [Homo sapiens]
Length = 322
Score = 64.7 bits (156), Expect = 2e-10
Identities = 54/174 (31%), Positives = 88/174 (50%), Gaps = 19/174 (10%)
Query: 366 LQEAWTEGRRFRVV---------VVDSRPWLEG-RHTLRSLVHAGVPASYLL--IPAASY 413
L E W E R R + V+++RP+ +G R T LV+ +PA+ + + AA+
Sbjct: 129 LCEHWEEHTRQRELPLRGPLGGTVLETRPYNQGARLTAFELVYEQIPATLITDSMVAAAM 188
Query: 414 VLPEVSKVLLGAHALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCERVQTDAFV 473
VS V++GA ++ANG ++VGT QLA+VA+ H +P V + R++T +
Sbjct: 189 AHRGVSAVVVGADRVVANGDTANKVGTYQLAIVAKHHGIPFYVAAPSSSCDLRLETGKEI 248
Query: 474 SNELDDPDDLQCKRGEHVALANWQNHASLRLLNLVYDVTPPELV-DLVITELGM 526
E +L G +A + + N +DVTP +L+ +ITELG+
Sbjct: 249 IIEERPGQELTDVNGVRIAA------PGIGVWNPAFDVTPHDLITGGIITELGV 296
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 47.0 bits (110), Expect = 4e-05
Identities = 47/213 (22%), Positives = 89/213 (41%), Gaps = 24/213 (11%)
Query: 2 PTQQPAAPSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEE----- 56
P ++ A A P + + S + S + S K E P A E KEE
Sbjct: 519 PVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPE--KEEAKSPA 576
Query: 57 --------KLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPR 108
K ++E K + + EK P A S A+ + P +E +S ++ +P
Sbjct: 577 EVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPE 636
Query: 109 E-KVPAG-------RSKAELRAERRAKQEAERALK-QARKGEQGGPPPKASPSTAGETPS 159
+ K P ++K+ + E ++ ++A+ +K +A+ E+ P KA + + S
Sbjct: 637 KAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKS 696
Query: 160 GVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKD 192
VK + P+ ++ K PE+ + P +++
Sbjct: 697 PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729
Score = 42.0 bits (97), Expect = 0.001
Identities = 43/198 (21%), Positives = 81/198 (40%), Gaps = 18/198 (9%)
Query: 2 PTQQPAAPSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQLR 61
P ++ A P ++ S + S A++ S KA+ P A + E K ++
Sbjct: 567 PEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEA---KSPAEAKSPVK 623
Query: 62 KEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTP---------REKVP 112
+E K + + EK P A S + + P +E +S + +P + K P
Sbjct: 624 EEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSP 683
Query: 113 AGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDD 172
KAE ++ +AK + ++A+ E+ P K + + S VK + P+
Sbjct: 684 V---KAEAKSPEKAKSPVK---EEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAK 737
Query: 173 LLLRRLVKKPERQQVPTR 190
++ K PE+ + P +
Sbjct: 738 SPVKEEAKSPEKAKSPEK 755
Score = 38.5 bits (88), Expect = 0.016
Identities = 45/194 (23%), Positives = 77/194 (39%), Gaps = 63/194 (32%)
Query: 48 VGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETG------------------------- 82
V E+T+EE EK+ ++++ KEE+G E E
Sbjct: 466 VTEEVTEEE------EKEAKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP 519
Query: 83 ---SAVSAAQCQGPTRELPESGIQLGTP-REKVPA-----------------GRSKAELR 121
A S A+ + P +E +S ++ +P + K PA +S AE++
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK 579
Query: 122 AERRAKQEAERALK---QARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRL 178
+ +AK A+ K +A+ E+ P K + E S VK + P
Sbjct: 580 SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE-------- 631
Query: 179 VKKPERQQVPTRKD 192
VK PE+ + PT+++
Sbjct: 632 VKSPEKAKSPTKEE 645
Score = 37.0 bits (84), Expect = 0.046
Identities = 42/162 (25%), Positives = 67/162 (41%), Gaps = 22/162 (13%)
Query: 38 KAELPPGPGAVGREMTKEEKLQLRKEKKQQKKK--RKEEKGAEPETGSAVSAAQCQGPTR 95
KAE P E K+ K + +K+ K K K+E E S V A +
Sbjct: 841 KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEA------KK 894
Query: 96 ELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQ---ARKGEQGGPPPK--AS 150
E E ++ TP ++ PA K E++ + + K++ E A K+ A+ E P K A+
Sbjct: 895 EEAEDKKKVPTPEKEAPA---KVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAA 951
Query: 151 PSTAGETPSGVKRLPEYPQV------DDLLLRRLVKKPERQQ 186
P K+ E P+ DD L + KP+ ++
Sbjct: 952 PEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEK 993
>gi|157785645 SPEG complex locus [Homo sapiens]
Length = 3267
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/138 (28%), Positives = 61/138 (44%), Gaps = 21/138 (15%)
Query: 46 GAVGREMTKEEKLQLRKEKKQ--QKKKRKEEKG--------AEPETGSAVSAAQCQGPTR 95
G + R ++EE ++ + + Q+ E G + P+T AVS A Q P+
Sbjct: 499 GRIRRSTSREELVRSHESLRATLQRAPSPREPGEPPLFSRPSTPKTSRAVSPAAAQPPSP 558
Query: 96 ELPES-GIQLGTPREKVPAGRS------KAELRAERRAKQEAERALKQARKGEQGGPPPK 148
E G + G PR + PAGR+ + E+R + RA+++ R PPP
Sbjct: 559 SSAEKPGDEPGRPRSRGPAGRTEPGEGPQQEVRRRDQFPLTRSRAIQECRSPV---PPPA 615
Query: 149 ASPSTA-GETPSGVKRLP 165
A P A + P G KR P
Sbjct: 616 ADPPEARTKAPPGRKREP 633
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
sapiens]
Length = 816
Score = 41.2 bits (95), Expect = 0.002
Identities = 54/247 (21%), Positives = 84/247 (34%), Gaps = 29/247 (11%)
Query: 1 MPTQQPAAPSTRAPKPSRSLSGSLCALFSDADSG-----SGMKAELPPGP-GAVGREMTK 54
+P P A TR +P S G + G PGP G G ++
Sbjct: 70 IPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISA 129
Query: 55 EEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAG 114
EE + R + + K+ GA +T R +G ++G PR P+
Sbjct: 130 EETVA-RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRP-APSA 187
Query: 115 RSKAELRAERRAKQEA------ERALKQARKGEQGG-------------PPPKASPSTAG 155
R + R++ A E + R+ GG P +SP+ +G
Sbjct: 188 RPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSG 247
Query: 156 ETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQF 215
+ G R P +P + ++ P Q P RKD + S P + S
Sbjct: 248 PSARGTPRAPAHPSQPKPKGLQALRPP--QVTPPRKDAAPALGPLSSSPLATPSPSAPPS 305
Query: 216 MSIPSSV 222
S P S+
Sbjct: 306 PSAPPSL 312
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/153 (24%), Positives = 56/153 (36%), Gaps = 19/153 (12%)
Query: 9 PSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQK 68
P+ RA KP S + GS + E P G R K + L+
Sbjct: 259 PAKRAKKPEEESESS--------EEGSESEEEAPAGT----RSQVKASEKILQVRAASAP 306
Query: 69 KKRKEEKGAEP----ETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAER 124
K KGA P + G+ S + P + S + E+ PA ++ + +A
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
Query: 125 RAKQ---EAERALKQARKGEQGGPPPKASPSTA 154
+ Q + A + RKG PP K P+ A
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 399
Score = 38.1 bits (87), Expect = 0.021
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 35 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 91
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 92 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 142
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 441 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 143 GGPPPKASPSTAGETPSG 160
G P ST G P G
Sbjct: 501 GKSPQVKPASTMGMGPLG 518
Score = 29.3 bits (64), Expect = 9.6
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 40 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 89
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1383 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1437
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/153 (24%), Positives = 56/153 (36%), Gaps = 19/153 (12%)
Query: 9 PSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQK 68
P+ RA KP S + GS + E P G R K + L+
Sbjct: 259 PAKRAKKPEEESESS--------EEGSESEEEAPAGT----RSQVKASEKILQVRAASAP 306
Query: 69 KKRKEEKGAEP----ETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAER 124
K KGA P + G+ S + P + S + E+ PA ++ + +A
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
Query: 125 RAKQ---EAERALKQARKGEQGGPPPKASPSTA 154
+ Q + A + RKG PP K P+ A
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 399
Score = 38.1 bits (87), Expect = 0.021
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 35 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 91
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 92 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 142
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 441 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 143 GGPPPKASPSTAGETPSG 160
G P ST G P G
Sbjct: 501 GKSPQVKPASTMGMGPLG 518
Score = 29.3 bits (64), Expect = 9.6
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 40 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 89
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1420 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1474
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/153 (24%), Positives = 56/153 (36%), Gaps = 19/153 (12%)
Query: 9 PSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQK 68
P+ RA KP S + GS + E P G R K + L+
Sbjct: 259 PAKRAKKPEEESESS--------EEGSESEEEAPAGT----RSQVKASEKILQVRAASAP 306
Query: 69 KKRKEEKGAEP----ETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAER 124
K KGA P + G+ S + P + S + E+ PA ++ + +A
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
Query: 125 RAKQ---EAERALKQARKGEQGGPPPKASPSTA 154
+ Q + A + RKG PP K P+ A
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 399
Score = 38.1 bits (87), Expect = 0.021
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 35 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 91
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 92 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 142
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 441 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 143 GGPPPKASPSTAGETPSG 160
G P ST G P G
Sbjct: 501 GKSPQVKPASTMGMGPLG 518
Score = 29.3 bits (64), Expect = 9.6
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 40 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 89
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1382 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1436
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 40.8 bits (94), Expect = 0.003
Identities = 37/153 (24%), Positives = 56/153 (36%), Gaps = 19/153 (12%)
Query: 9 PSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQK 68
P+ RA KP S + GS + E P G R K + L+
Sbjct: 259 PAKRAKKPEEESESS--------EEGSESEEEAPAGT----RSQVKASEKILQVRAASAP 306
Query: 69 KKRKEEKGAEP----ETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAER 124
K KGA P + G+ S + P + S + E+ PA ++ + +A
Sbjct: 307 AKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASG 366
Query: 125 RAKQ---EAERALKQARKGEQGGPPPKASPSTA 154
+ Q + A + RKG PP K P+ A
Sbjct: 367 KTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 399
Score = 38.1 bits (87), Expect = 0.021
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 35 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 91
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 381 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 440
Query: 92 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 142
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 441 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 500
Query: 143 GGPPPKASPSTAGETPSG 160
G P ST G P G
Sbjct: 501 GKSPQVKPASTMGMGPLG 518
>gi|11067749 bromodomain containing protein 3 [Homo sapiens]
Length = 726
Score = 40.8 bits (94), Expect = 0.003
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 25/148 (16%)
Query: 2 PTQQPAAPSTRAPKPSRSLSGSLCALFSDADSGSGMK--------AELPPGPGAVGREMT 53
P + PA P+ AP S+ S + S +DSGS AEL AV ++
Sbjct: 419 PVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLA 478
Query: 54 --------KEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLG 105
K +K + +KEK+++KK +++EK A+ P ++
Sbjct: 479 ALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQ--------- 529
Query: 106 TPREKVPAGRSKAELRAERRAKQEAERA 133
++K PA ++ + A R+ K+ ++A
Sbjct: 530 AQQKKAPAKKANSTTTAGRQLKKGGKQA 557
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 40.4 bits (93), Expect = 0.004
Identities = 37/136 (27%), Positives = 57/136 (41%), Gaps = 26/136 (19%)
Query: 33 SGSGMKAELP-PGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQ 91
+ G+ LP P + +KE + Q ++ +KQ+K+++K+EK E E
Sbjct: 697 TAEGLHPSLPSPTGNSTPLGSSKETRKQEKERQKQEKERQKQEKEREKE----------- 745
Query: 92 GPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP 151
R+ E REK R K E +++ K+ R L RK + GPP P
Sbjct: 746 ---RQKQEK------EREKQEKEREKQEKERQKQEKKAQGRKLSLRRKAD--GPP---GP 791
Query: 152 STAGETPSGVKRLPEY 167
G+ PS R Y
Sbjct: 792 HDGGDRPSAEARQDAY 807
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 40.4 bits (93), Expect = 0.004
Identities = 37/153 (24%), Positives = 62/153 (40%), Gaps = 17/153 (11%)
Query: 6 PAAPSTRAPKPSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGRE-----MTKEEKLQL 60
P + + K S S + SD+DS S ++ E K+ +
Sbjct: 179 PKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNS 238
Query: 61 RKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAEL 120
RK KK++KK++K +K A E+ + AQ Q R P E P ++ +
Sbjct: 239 RKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVR-----------PEEIPPIPENRFLM 287
Query: 121 RAERRAKQEAERALKQARKGEQGGPPPKASPST 153
R E ER ++ R+ E+ PP + P++
Sbjct: 288 RKSPPKADEKERKNRE-RERERECNPPNSQPAS 319
Score = 30.4 bits (67), Expect = 4.3
Identities = 27/156 (17%), Positives = 65/156 (41%), Gaps = 12/156 (7%)
Query: 38 KAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTREL 97
K + P A R ++ E + K KK++KK+ K + + + S++ Q +
Sbjct: 158 KTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSD-- 215
Query: 98 PESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGET 157
+ E +SK + R+ ++ ++ K+ +K ++ + + +
Sbjct: 216 -------SSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQP 268
Query: 158 PSGVK--RLPEYPQVDDLLLRRLVKKPERQQVPTRK 191
S V+ +P P+ + L+R+ K + ++ R+
Sbjct: 269 QSTVRPEEIPPIPE-NRFLMRKSPPKADEKERKNRE 303
>gi|24308289 leukocyte receptor cluster (LRC) member 1 [Homo
sapiens]
Length = 264
Score = 40.0 bits (92), Expect = 0.005
Identities = 38/144 (26%), Positives = 64/144 (44%), Gaps = 18/144 (12%)
Query: 43 PGPGAVG--REMTKEEKLQLR------KEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPT 94
PG G V RE+ +E K +R +EK+Q+K+++++ G G + + AQ Q P
Sbjct: 71 PGSGPVDLFRELLEEGKGVIRGNKEYEEEKRQEKERQEKALGILTYLGQSAAEAQTQPPW 130
Query: 95 RELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTA 154
+LP + G P P + K+ L R ++ + K+ G++G K +
Sbjct: 131 YQLPPG--RGGPPPGPAPDEKIKSRLDPLREMQKHLGK--KRQHGGDEGSRSRKEKEGSE 186
Query: 155 GETPSGVKRLPEYPQVDDLLLRRL 178
+ P E P +D L RL
Sbjct: 187 KQRPK------EPPSLDQLRAERL 204
Score = 30.4 bits (67), Expect = 4.3
Identities = 26/106 (24%), Positives = 49/106 (46%), Gaps = 6/106 (5%)
Query: 40 ELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPE 99
+LPPG G +EK++ R + ++ +K +K + S + +G ++ P+
Sbjct: 132 QLPPGRGGPPPGPAPDEKIKSRLDPLREMQKHLGKKRQHGGDEGSRSRKEKEGSEKQRPK 191
Query: 100 SGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGP 145
L +++ A R + E A R++ EA A Q R ++G P
Sbjct: 192 EPPSL----DQLRAERLRRE--AAERSRAEALLARVQGRALQEGQP 231
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 39.7 bits (91), Expect = 0.007
Identities = 48/200 (24%), Positives = 73/200 (36%), Gaps = 33/200 (16%)
Query: 2 PTQQPAA-PSTRAPKPSRSLSGSLCALFSDADSGSGMK-AELPPGPGAVGREMTKEEKLQ 59
P ++P P R PKP R S S SD+DS + +E A RE+ + +
Sbjct: 279 PAEKPLPKPRGRKPKPERPPSSSS----SDSDSDEVDRISEWKRRDEARRRELEARRRRE 334
Query: 60 LRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAE 119
+E ++ +++ KEEK E A + G G S E
Sbjct: 335 QEEELRRLREQEKEEKERRRERADRGEAERGSG---------------------GSSGDE 373
Query: 120 LRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLV 179
LR ++ E K+ RKG GPP + E K+ + PQ R
Sbjct: 374 LR------EDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKP 427
Query: 180 KKPERQQVPTRKDYGSKVSL 199
+ E++ P K V +
Sbjct: 428 GQKEKRVRPEEKQQAKPVKV 447
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 39.7 bits (91), Expect = 0.007
Identities = 48/200 (24%), Positives = 73/200 (36%), Gaps = 33/200 (16%)
Query: 2 PTQQPAA-PSTRAPKPSRSLSGSLCALFSDADSGSGMK-AELPPGPGAVGREMTKEEKLQ 59
P ++P P R PKP R S S SD+DS + +E A RE+ + +
Sbjct: 279 PAEKPLPKPRGRKPKPERPPSSSS----SDSDSDEVDRISEWKRRDEARRRELEARRRRE 334
Query: 60 LRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAE 119
+E ++ +++ KEEK E A + G G S E
Sbjct: 335 QEEELRRLREQEKEEKERRRERADRGEAERGSG---------------------GSSGDE 373
Query: 120 LRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLV 179
LR ++ E K+ RKG GPP + E K+ + PQ R
Sbjct: 374 LR------EDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARKP 427
Query: 180 KKPERQQVPTRKDYGSKVSL 199
+ E++ P K V +
Sbjct: 428 GQKEKRVRPEEKQQAKPVKV 447
>gi|217035154 RCSD domain containing 1 [Homo sapiens]
Length = 416
Score = 39.3 bits (90), Expect = 0.009
Identities = 30/102 (29%), Positives = 50/102 (49%), Gaps = 14/102 (13%)
Query: 73 EEKGAEPETGSAVSAAQCQGPTRELPESG-----IQLGTPREKVPAGRSKAELRAERRAK 127
++ GA+ E G V ++ + P L G ++ P EK P RS + R K
Sbjct: 194 QQNGAKEEDGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPS-----RTEK 248
Query: 128 QEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQ 169
QE +RA ++A+ GE+ ++S G+ P+ + +PE PQ
Sbjct: 249 QEEDRATEEAKNGEKA---RRSSEEVDGQHPA-QEEVPESPQ 286
Score = 38.1 bits (87), Expect = 0.021
Identities = 41/159 (25%), Positives = 64/159 (40%), Gaps = 28/159 (17%)
Query: 30 DADSGSGMKAELPPGP----GAVG---REMTKEEKLQLRK-----EKKQQKKKRKEEKGA 77
D D K++ P P GA G R + EK LR+ EK+++ + +E K
Sbjct: 202 DGDEVLPSKSKAPGSPLSSEGAAGEGVRTLGPAEKPPLRRSPSRTEKQEEDRATEEAKNG 261
Query: 78 EPETGSA--------VSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQE 129
E S+ + P PE+ + G+PRE+ PAG E E+ + +
Sbjct: 262 EKARRSSEEVDGQHPAQEEVPESPQTSGPEAENRCGSPREEKPAGE---EAEMEKATEVK 318
Query: 130 AERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYP 168
ER + E+ GP + + E + VK P P
Sbjct: 319 GERV-----QNEEVGPEHDSQETKKLEEGAAVKETPHSP 352
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 38.5 bits (88), Expect = 0.016
Identities = 53/225 (23%), Positives = 88/225 (39%), Gaps = 30/225 (13%)
Query: 17 SRSLSGSLCALFSDADSGSG---------MKAELP-PGPGAVGRE----MTKEEKLQLRK 62
SRSLS S + S A S S M A+L P A R T++EK + +K
Sbjct: 702 SRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKK 761
Query: 63 EKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQL--GTPREKVPAGRSKAEL 120
E +++KRK + +P + A G + + P + Q G P++ + +L
Sbjct: 762 EDGVKEEKRKRDSSTQPPKSAKPPAG---GKSSQQPSTPQQAPPGQPQQGTFVAHKEIKL 818
Query: 121 RAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVK 180
+A + R + ++ PPP P+T+ + S ++ R
Sbjct: 819 TLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDRKSGG---------RLGSP 869
Query: 181 KPERQQVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHP 225
KPERQ+ K + L S+ +S + S+P P
Sbjct: 870 KPERQRGQNSKAPAAPADRKRQLSPQSKSSS--KVTSVPGKASDP 912
Score = 32.0 bits (71), Expect = 1.5
Identities = 26/95 (27%), Positives = 41/95 (43%), Gaps = 11/95 (11%)
Query: 50 REMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPRE 109
RE K ++ + + ++K+R++EKG + Q + P +E +G Q+ E
Sbjct: 455 RERAKRDEKDRQHRDRDREKEREKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADE 514
Query: 110 -KVPAGRSK----------AELRAERRAKQEAERA 133
K P RSK + RA RR K A A
Sbjct: 515 WKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSA 549
Score = 30.8 bits (68), Expect = 3.3
Identities = 36/169 (21%), Positives = 69/169 (40%), Gaps = 19/169 (11%)
Query: 54 KEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPA 113
+E + + +E +Q++++R+ E+ E E + Q E R K
Sbjct: 402 RERERERERENRQRERERERERDRERE--------RRQREREREREHERDKERQRRKEEW 453
Query: 114 GRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASPSTAGETPSGVKRLPEYPQVDDL 173
R +A + + + +Q +R ++ R+ E+G P P+ +P R E P+ +
Sbjct: 454 ERERA--KRDEKDRQHRDRDREKEREKEKGKPKPR--------SPQPPSRQAEPPKKEAA 503
Query: 174 LLRRLVKKPERQQVPTRKDYGSKVSL-FSHLPQYSRQNSLTQFMSIPSS 221
VK+ + + P R+ K L S P +R+ T S +S
Sbjct: 504 TTGPQVKRADEWKDPWRRSKSPKKKLGVSVSPSRARRRRKTSASSASAS 552
>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
sapiens]
Length = 1124
Score = 38.1 bits (87), Expect = 0.021
Identities = 44/197 (22%), Positives = 72/197 (36%), Gaps = 24/197 (12%)
Query: 43 PGP-GAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESG 101
PGP G G ++ EE + R + + K+ GA +T R +G
Sbjct: 126 PGPLGQKGLRISAEETVA-RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAG 184
Query: 102 IQLGTPREKVPAGRSKAELRAERRAKQEA------ERALKQARKGEQGG----------- 144
++G PR P+ R + R++ A E + R+ GG
Sbjct: 185 TEVGLPRP-APSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 243
Query: 145 --PPPKASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQVPTRKDYGSKVSLFSH 202
P +SP+ +G + G R P +P + ++ P Q P RKD + S
Sbjct: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPP--QVTPPRKDAAPALGPLSS 301
Query: 203 LPQYSRQNSLTQFMSIP 219
P + S T+ +P
Sbjct: 302 SPLATPSPSGTKARPVP 318
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 38.1 bits (87), Expect = 0.021
Identities = 25/90 (27%), Positives = 44/90 (48%), Gaps = 13/90 (14%)
Query: 50 REMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPRE 109
++ TKE + + KE++++K+KRK +K E E RE E + E
Sbjct: 43 KKKTKETEKRKEKEEEEKKRKRKRKKKKEEEE-------------REEEEEEEEEEKEEE 89
Query: 110 KVPAGRSKAELRAERRAKQEAERALKQARK 139
+ GR + + + RR ++E E+ K+ RK
Sbjct: 90 EKEEGRRRKKKKKRRRKEEEEEKKKKRRRK 119
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 38.1 bits (87), Expect = 0.021
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 35 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 91
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 304 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 363
Query: 92 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 142
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 364 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 143 GGPPPKASPSTAGETPSG 160
G P ST G P G
Sbjct: 424 GKSPQVKPASTMGMGPLG 441
Score = 34.7 bits (78), Expect = 0.23
Identities = 35/170 (20%), Positives = 62/170 (36%), Gaps = 25/170 (14%)
Query: 10 STRAPKPSRSLSGSLCALFSDADSGS--GMKAELPPGPGAVGREMTKEEKLQLRKEKKQQ 67
S ++P+ S S + + + GS A PG + G+ + E ++
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDV 212
Query: 68 KKKRKEE----------------KGAEP----ETGSAVSAAQCQGPTRELPESGIQLGTP 107
+ K E+ KGA P + G+ S + P + S +
Sbjct: 213 EVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 272
Query: 108 REKVPAGRSKAELRAERRAKQ---EAERALKQARKGEQGGPPPKASPSTA 154
E+ PA ++ + +A + Q + A + RKG PP K P+ A
Sbjct: 273 EEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322
Score = 29.3 bits (64), Expect = 9.6
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 40 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 89
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1344 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1398
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 38.1 bits (87), Expect = 0.021
Identities = 33/138 (23%), Positives = 54/138 (39%), Gaps = 12/138 (8%)
Query: 35 SGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPE---TGSAVSAAQCQ 91
S K P PG G + K + + ++ + ++ E+ A + +G A
Sbjct: 304 SPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAAS 363
Query: 92 GPTRELPESGIQLGTPREKVPA------GRSKAELRA---ERRAKQEAERALKQARKGEQ 142
P +E P G PR+ PA G+ + + R+ E + +EA A+ A+
Sbjct: 364 APAKESPRKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNAAQVKPL 423
Query: 143 GGPPPKASPSTAGETPSG 160
G P ST G P G
Sbjct: 424 GKSPQVKPASTMGMGPLG 441
Score = 34.7 bits (78), Expect = 0.23
Identities = 35/170 (20%), Positives = 62/170 (36%), Gaps = 25/170 (14%)
Query: 10 STRAPKPSRSLSGSLCALFSDADSGS--GMKAELPPGPGAVGREMTKEEKLQLRKEKKQQ 67
S ++P+ S S + + + GS A PG + G+ + E ++
Sbjct: 153 SGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQADSSSEDTSSSSDETDV 212
Query: 68 KKKRKEE----------------KGAEP----ETGSAVSAAQCQGPTRELPESGIQLGTP 107
+ K E+ KGA P + G+ S + P + S +
Sbjct: 213 EVKASEKILQVRAASAPAKGTPGKGATPAPPGKAGAVASQTKAGKPEEDSESSSEESSDS 272
Query: 108 REKVPAGRSKAELRAERRAKQ---EAERALKQARKGEQGGPPPKASPSTA 154
E+ PA ++ + +A + Q + A + RKG PP K P+ A
Sbjct: 273 EEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAPAPPGKTGPAVA 322
Score = 29.3 bits (64), Expect = 9.6
Identities = 18/55 (32%), Positives = 28/55 (50%), Gaps = 5/55 (9%)
Query: 40 ELPPGPGAV-----GREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQ 89
EL G G V +K+EK + K KK ++KK K++K + T + S +Q
Sbjct: 1343 ELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKEKKKKAKKASTKDSESPSQ 1397
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 37.7 bits (86), Expect = 0.027
Identities = 37/159 (23%), Positives = 63/159 (39%), Gaps = 14/159 (8%)
Query: 42 PPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQG---PTRELP 98
P G + G + K +K++ K+K KE+K P T G P E P
Sbjct: 1249 PKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPATTPEARVLGKDGKEKPKEERP 1308
Query: 99 ESGIQLGTPREKVP-AGRSKAELRAERRAKQE--------AERALKQARKGEQGGPPPK- 148
+ +E+ P + + K + + E +AK E AE Q R+ E+ +
Sbjct: 1309 NKDEKARETKERTPKSDKEKEKFKKEEKAKDEKFKTTVPNAESKSTQEREREKEPSRERD 1368
Query: 149 -ASPSTAGETPSGVKRLPEYPQVDDLLLRRLVKKPERQQ 186
A + E G ++ P + + R + +PER+Q
Sbjct: 1369 IAKEMKSKENVKGGEKTPVSGSLKSPVPRSDIPEPEREQ 1407
>gi|21361517 UBX domain protein 1 [Homo sapiens]
Length = 312
Score = 37.7 bits (86), Expect = 0.027
Identities = 40/146 (27%), Positives = 65/146 (44%), Gaps = 16/146 (10%)
Query: 34 GSGMKA-ELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEKGAEPET-----GSAVSA 87
GSG A E P R+ + L+L +K++++++R+E + E E G +SA
Sbjct: 74 GSGSAAGEGKPALSEEERQEQTKRMLELVAQKQREREEREEREALERERQRRRQGQELSA 133
Query: 88 AQCQGPTRELPESGIQLGTPREKVPAGRSKAELRAERRAKQEAERALKQARKGEQGGPPP 147
A+ + E+ + + + + A R + + ER +AERA K G G PP
Sbjct: 134 ARQRLQEDEMRRAAEERRREKAEELAARQRVREKIER---DKAERAKKYG--GSVGSQPP 188
Query: 148 KASPSTAGETPSGVKRLP----EYPQ 169
+P G PS + P EY Q
Sbjct: 189 PVAPE-PGPVPSSPSQEPPTKREYDQ 213
>gi|22538461 nuclear receptor co-repressor 1 [Homo sapiens]
Length = 2440
Score = 37.4 bits (85), Expect = 0.035
Identities = 23/65 (35%), Positives = 32/65 (49%)
Query: 16 PSRSLSGSLCALFSDADSGSGMKAELPPGPGAVGREMTKEEKLQLRKEKKQQKKKRKEEK 75
PS +SG C +A K EL V RE+ K E+ L+ +KKQQ+ + + K
Sbjct: 156 PSSPISGQPCGDDQNASPSKLSKEELIQSMDRVDREIAKVEQQILKLKKKQQQLEEEAAK 215
Query: 76 GAEPE 80
EPE
Sbjct: 216 PPEPE 220
Score = 34.7 bits (78), Expect = 0.23
Identities = 29/99 (29%), Positives = 41/99 (41%), Gaps = 2/99 (2%)
Query: 54 KEEKLQLRKEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPR-EKVP 112
KEE + EKK+++KK +EEK + ++ T E E Q TPR K
Sbjct: 517 KEEDKAEKTEKKEEEKKDEEEKDEKEDSKENTKEKDKIDGTAEETEEREQ-ATPRGRKTA 575
Query: 113 AGRSKAELRAERRAKQEAERALKQARKGEQGGPPPKASP 151
+ + + R R EA A A + PPP P
Sbjct: 576 NSQGRRKGRITRSMTNEAAAASAAAAAATEEPPPPLPPP 614
>gi|53692189 adipocyte enhancer binding protein 1 precursor [Homo
sapiens]
Length = 1158
Score = 37.4 bits (85), Expect = 0.035
Identities = 25/97 (25%), Positives = 43/97 (44%), Gaps = 2/97 (2%)
Query: 62 KEKKQQKKKRKEEKGAEPETGSAVSAAQCQGPTRELPESGIQLGTPREKVPAGRSKAELR 121
++ K + KK K++KG + S + + +E P + P+EK P K + +
Sbjct: 88 EKTKDKGKKGKKDKGPKVPKESLEGSPRPPKKGKEKPPKATK--KPKEKPPKATKKPKEK 145
Query: 122 AERRAKQEAERALKQARKGEQGGPPPKASPSTAGETP 158
+ K+ E+ K +K G PP +PS E P
Sbjct: 146 PPKATKKPKEKPPKATKKPPSGKRPPILAPSETLEWP 182
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.370
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,481,690
Number of Sequences: 37866
Number of extensions: 1138775
Number of successful extensions: 10632
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 424
Number of HSP's that attempted gapping in prelim test: 8660
Number of HSP's gapped (non-prelim): 1799
length of query: 543
length of database: 18,247,518
effective HSP length: 107
effective length of query: 436
effective length of database: 14,195,856
effective search space: 6189393216
effective search space used: 6189393216
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.