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Search of human proteins with 187475373
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187475373 c-src tyrosine kinase [Homo sapiens]
(450 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187475373 c-src tyrosine kinase [Homo sapiens] 920 0.0
gi|4758078 c-src tyrosine kinase [Homo sapiens] 920 0.0
gi|21450844 megakaryocyte-associated tyrosine kinase isoform c [... 483 e-136
gi|21450842 megakaryocyte-associated tyrosine kinase isoform b [... 483 e-136
gi|21450846 megakaryocyte-associated tyrosine kinase isoform a [... 483 e-136
gi|153266778 arg tyrosine kinase isoform c [Homo sapiens] 316 2e-86
gi|6382062 arg tyrosine kinase isoform b [Homo sapiens] 316 2e-86
gi|209862778 arg tyrosine kinase isoform e [Homo sapiens] 316 2e-86
gi|209862772 arg tyrosine kinase isoform d [Homo sapiens] 316 2e-86
gi|153266757 arg tyrosine kinase isoform a [Homo sapiens] 316 2e-86
gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a... 312 5e-85
gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b... 312 5e-85
gi|112789548 lymphocyte-specific protein tyrosine kinase precurs... 297 1e-80
gi|112789546 lymphocyte-specific protein tyrosine kinase precurs... 297 1e-80
gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo sap... 294 1e-79
gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo sapi... 294 1e-79
gi|33469982 B lymphoid tyrosine kinase [Homo sapiens] 293 3e-79
gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens] 293 3e-79
gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog ... 291 1e-78
gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog is... 291 1e-78
gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens] 286 3e-77
gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 285 5e-77
gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo sa... 285 5e-77
gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo sapi... 285 5e-77
gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens] 285 6e-77
gi|148596974 TXK tyrosine kinase [Homo sapiens] 285 6e-77
gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens] 278 7e-75
gi|4503787 fyn-related kinase [Homo sapiens] 276 3e-74
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 274 1e-73
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 271 1e-72
>gi|187475373 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 920 bits (2379), Expect = 0.0
Identities = 450/450 (100%), Positives = 450/450 (100%)
Query: 1 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
Sbjct: 1 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60
Query: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
Sbjct: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120
Query: 121 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ 180
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
Sbjct: 121 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ 180
Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM 240
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
Sbjct: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM 240
Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300
Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE 360
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE 360
Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 420
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
Sbjct: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 420
Query: 421 NCWHLDAAMRPSFLQLREQLEHIKTHELHL 450
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
Sbjct: 421 NCWHLDAAMRPSFLQLREQLEHIKTHELHL 450
>gi|4758078 c-src tyrosine kinase [Homo sapiens]
Length = 450
Score = 920 bits (2379), Expect = 0.0
Identities = 450/450 (100%), Positives = 450/450 (100%)
Query: 1 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII
Sbjct: 1 MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGII 60
Query: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120
PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV
Sbjct: 61 PANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCV 120
Query: 121 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ 180
SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ
Sbjct: 121 SCDGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ 180
Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM 240
DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM
Sbjct: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVM 240
Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300
TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE
Sbjct: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300
Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE 360
AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE
Sbjct: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALRE 360
Query: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 420
KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK
Sbjct: 361 KKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMK 420
Query: 421 NCWHLDAAMRPSFLQLREQLEHIKTHELHL 450
NCWHLDAAMRPSFLQLREQLEHIKTHELHL
Sbjct: 421 NCWHLDAAMRPSFLQLREQLEHIKTHELHL 450
>gi|21450844 megakaryocyte-associated tyrosine kinase isoform c
[Homo sapiens]
Length = 466
Score = 483 bits (1242), Expect = e-136
Identities = 235/434 (54%), Positives = 316/434 (72%), Gaps = 3/434 (0%)
Query: 8 WPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQ 66
W GT+CI K +L F KGDV+TI+ ++ +WY+ K+ G+EG++ A ++
Sbjct: 6 WAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR 65
Query: 67 KREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKV 126
+RE + A KLSLMPWFHGKI+ ++A + L PPE GLFLVRES +PGDY LCVS V
Sbjct: 66 EREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDV 125
Query: 127 EHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186
HYR+++ L+IDE V+F NLM +VEHY+ D +CT+L++PK GT +A++E R+
Sbjct: 126 IHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA 185
Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHS 246
GW LN++ L L IG+GEFG V+ G+Y G KVAVK IK D TAQAFL E +VMT+++H
Sbjct: 186 GWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHE 245
Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306
NLV+LLGVI+ + GLYIV E+++KG+LV++LR+RGR+++ LL+FSL V E MEYLE
Sbjct: 246 NLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE 303
Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366
VHRDLAARN+LVSED VAKVSDFGL K D+ +LPVKWTAPEAL+ KF++K
Sbjct: 304 SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSK 363
Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 426
SDVWSFG+LLWE++S+GR PYP++ LK+V VEKGY+M+ P+GCP V+ +M +CW +
Sbjct: 364 SDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAE 423
Query: 427 AAMRPSFLQLREQL 440
A RP F +L E+L
Sbjct: 424 PARRPPFRKLAEKL 437
>gi|21450842 megakaryocyte-associated tyrosine kinase isoform b
[Homo sapiens]
Length = 508
Score = 483 bits (1242), Expect = e-136
Identities = 235/434 (54%), Positives = 316/434 (72%), Gaps = 3/434 (0%)
Query: 8 WPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQ 66
W GT+CI K +L F KGDV+TI+ ++ +WY+ K+ G+EG++ A ++
Sbjct: 48 WAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR 107
Query: 67 KREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKV 126
+RE + A KLSLMPWFHGKI+ ++A + L PPE GLFLVRES +PGDY LCVS V
Sbjct: 108 EREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDV 167
Query: 127 EHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186
HYR+++ L+IDE V+F NLM +VEHY+ D +CT+L++PK GT +A++E R+
Sbjct: 168 IHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA 227
Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHS 246
GW LN++ L L IG+GEFG V+ G+Y G KVAVK IK D TAQAFL E +VMT+++H
Sbjct: 228 GWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHE 287
Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306
NLV+LLGVI+ + GLYIV E+++KG+LV++LR+RGR+++ LL+FSL V E MEYLE
Sbjct: 288 NLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE 345
Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366
VHRDLAARN+LVSED VAKVSDFGL K D+ +LPVKWTAPEAL+ KF++K
Sbjct: 346 SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSK 405
Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 426
SDVWSFG+LLWE++S+GR PYP++ LK+V VEKGY+M+ P+GCP V+ +M +CW +
Sbjct: 406 SDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAE 465
Query: 427 AAMRPSFLQLREQL 440
A RP F +L E+L
Sbjct: 466 PARRPPFRKLAEKL 479
>gi|21450846 megakaryocyte-associated tyrosine kinase isoform a
[Homo sapiens]
Length = 507
Score = 483 bits (1242), Expect = e-136
Identities = 235/434 (54%), Positives = 316/434 (72%), Gaps = 3/434 (0%)
Query: 8 WPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQ 66
W GT+CI K +L F KGDV+TI+ ++ +WY+ K+ G+EG++ A ++
Sbjct: 47 WAPGTQCITKCEHTRPKPGELAFRKGDVVTILEACENKSWYRVKHHTSGQEGLLAAGALR 106
Query: 67 KREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKV 126
+RE + A KLSLMPWFHGKI+ ++A + L PPE GLFLVRES +PGDY LCVS V
Sbjct: 107 EREALSADPKLSLMPWFHGKISGQEAVQQLQPPEDGLFLVRESARHPGDYVLCVSFGRDV 166
Query: 127 EHYRIMYHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186
HYR+++ L+IDE V+F NLM +VEHY+ D +CT+L++PK GT +A++E R+
Sbjct: 167 IHYRVLHRDGHLTIDEAVFFCNLMDMVEHYSKDKGAICTKLVRPKRKHGTKSAEEELARA 226
Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHS 246
GW LN++ L L IG+GEFG V+ G+Y G KVAVK IK D TAQAFL E +VMT+++H
Sbjct: 227 GWLLNLQHLTLGAQIGEGEFGAVLQGEYLGQKVAVKNIKCDVTAQAFLDETAVMTKMQHE 286
Query: 247 NLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLE 306
NLV+LLGVI+ + GLYIV E+++KG+LV++LR+RGR+++ LL+FSL V E MEYLE
Sbjct: 287 NLVRLLGVILHQ--GLYIVMEHVSKGNLVNFLRTRGRALVNTAQLLQFSLHVAEGMEYLE 344
Query: 307 GNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTK 366
VHRDLAARN+LVSED VAKVSDFGL K D+ +LPVKWTAPEAL+ KF++K
Sbjct: 345 SKKLVHRDLAARNILVSEDLVAKVSDFGLAKAERKGLDSSRLPVKWTAPEALKHGKFTSK 404
Query: 367 SDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLD 426
SDVWSFG+LLWE++S+GR PYP++ LK+V VEKGY+M+ P+GCP V+ +M +CW +
Sbjct: 405 SDVWSFGVLLWEVFSYGRAPYPKMSLKEVSEAVEKGYRMEPPEGCPGPVHVLMSSCWEAE 464
Query: 427 AAMRPSFLQLREQL 440
A RP F +L E+L
Sbjct: 465 PARRPPFRKLAEKL 478
>gi|153266778 arg tyrosine kinase isoform c [Homo sapiens]
Length = 1167
Score = 316 bits (810), Expect = 2e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 156
Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 157 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Query: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 211 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 269
Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 270 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 329
Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 330 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
Query: 425 LDAAMRPSFLQLREQLE 441
A RPSF + + E
Sbjct: 509 WSPADRPSFAETHQAFE 525
>gi|6382062 arg tyrosine kinase isoform b [Homo sapiens]
Length = 1182
Score = 316 bits (810), Expect = 2e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 113 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 171
Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 172 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 225
Query: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 226 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 284
Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 285 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 344
Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 345 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 403
Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 404 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 463
Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 464 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 523
Query: 425 LDAAMRPSFLQLREQLE 441
A RPSF + + E
Sbjct: 524 WSPADRPSFAETHQAFE 540
>gi|209862778 arg tyrosine kinase isoform e [Homo sapiens]
Length = 542
Score = 316 bits (810), Expect = 2e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 92 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 150
Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 151 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 204
Query: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 205 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 263
Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 264 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 323
Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 324 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 382
Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 383 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 442
Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 443 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 502
Query: 425 LDAAMRPSFLQLREQLE 441
A RPSF + + E
Sbjct: 503 WSPADRPSFAETHQAFE 519
>gi|209862772 arg tyrosine kinase isoform d [Homo sapiens]
Length = 1064
Score = 316 bits (810), Expect = 2e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 98 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 156
Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 157 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 210
Query: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 211 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 269
Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 270 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 329
Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 330 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 388
Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 389 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 448
Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 449 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 508
Query: 425 LDAAMRPSFLQLREQLE 441
A RPSF + + E
Sbjct: 509 WSPADRPSFAETHQAFE 525
>gi|153266757 arg tyrosine kinase isoform a [Homo sapiens]
Length = 1146
Score = 316 bits (810), Expect = 2e-86
Identities = 178/437 (40%), Positives = 257/437 (58%), Gaps = 19/437 (4%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y+F + + L KG+ L ++ ++ W + ++K G +G +P+NY+ ++
Sbjct: 77 VALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG-QGWVPSNYITPVNSLEKH 135
Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 136 S------WYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTT 189
Query: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
A K+ + E F L +LV H+++ ADGL T L PK + TV + W +
Sbjct: 190 ADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDK-WEME 248
Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
++ + +G G++G+V +G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 249 RTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 308
Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
VQLLGV E YIVTEYM G+L+DYLR R + LL + + AMEYLE
Sbjct: 309 VQLLGVCTLEPP-FYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKK 367
Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
NF+HRDLAARN LV E++V KV+DFGL++ + T K P+KWTAPE+L FS
Sbjct: 368 NFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFS 427
Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
KSDVW+FG+LLWEI ++G PYP I L V +EKGY+M+ P+GCPP VYE+M+ CW
Sbjct: 428 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWK 487
Query: 425 LDAAMRPSFLQLREQLE 441
A RPSF + + E
Sbjct: 488 WSPADRPSFAETHQAFE 504
>gi|62362414 c-abl oncogene 1, receptor tyrosine kinase isoform a
[Homo sapiens]
Length = 1130
Score = 312 bits (799), Expect = 5e-85
Identities = 175/437 (40%), Positives = 256/437 (58%), Gaps = 19/437 (4%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ ++
Sbjct: 67 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVNSLEKH 125
Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 126 S------WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 179
Query: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
+ KL + E F L +LV H+++ ADGL T L PK + TV Y W +
Sbjct: 180 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK-WEME 238
Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
++ + +G G++G+V G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 239 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 298
Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
VQLLGV E YI+TE+M G+L+DYLR R + LL + + AMEYLE
Sbjct: 299 VQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 357
Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
NF+HRDLAARN LV E+++ KV+DFGL++ + T K P+KWTAPE+L KFS
Sbjct: 358 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 417
Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
KSDVW+FG+LLWEI ++G PYP I L V +EK Y+M+ P+GCP VYE+M+ CW
Sbjct: 418 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 477
Query: 425 LDAAMRPSFLQLREQLE 441
+ + RPSF ++ + E
Sbjct: 478 WNPSDRPSFAEIHQAFE 494
>gi|62362412 c-abl oncogene 1, receptor tyrosine kinase isoform b
[Homo sapiens]
Length = 1149
Score = 312 bits (799), Expect = 5e-85
Identities = 175/437 (40%), Positives = 256/437 (58%), Gaps = 19/437 (4%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y+F + + L KG+ L ++ + W +A+ K G +G +P+NY+ ++
Sbjct: 86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNG-QGWVPSNYITPVNSLEKH 144
Query: 75 TKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCDGKVEHYRIMYH 134
+ W+HG ++R AE LL G FLVRES + PG ++ + +G+V HYRI
Sbjct: 145 S------WYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTA 198
Query: 135 AS-KLSIDEEVYFENLMQLVEHYTSDADGLCTRLI--KPKVMEGTVAAQDEFYRSGWALN 191
+ KL + E F L +LV H+++ ADGL T L PK + TV Y W +
Sbjct: 199 SDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDK-WEME 257
Query: 192 MKELKLLQTIGKGEFGDVMLGDYRGNK--VAVKCIKNDAT-AQAFLAEASVMTQLRHSNL 248
++ + +G G++G+V G ++ VAVK +K D + FL EA+VM +++H NL
Sbjct: 258 RTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNL 317
Query: 249 VQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGN 308
VQLLGV E YI+TE+M G+L+DYLR R + LL + + AMEYLE
Sbjct: 318 VQLLGVCTREPP-FYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKK 376
Query: 309 NFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALREKKFS 364
NF+HRDLAARN LV E+++ KV+DFGL++ + T K P+KWTAPE+L KFS
Sbjct: 377 NFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFS 436
Query: 365 TKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWH 424
KSDVW+FG+LLWEI ++G PYP I L V +EK Y+M+ P+GCP VYE+M+ CW
Sbjct: 437 IKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACWQ 496
Query: 425 LDAAMRPSFLQLREQLE 441
+ + RPSF ++ + E
Sbjct: 497 WNPSDRPSFAEIHQAFE 513
>gi|112789548 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 297 bits (761), Expect = 1e-80
Identities = 177/446 (39%), Positives = 260/446 (58%), Gaps = 28/446 (6%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73
IA +++ + + DL F KG+ L I+ + + W+KA++ G+EG IP N+V K
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGE--WWKAQSLTTGQEGFIPFNFVAK------ 118
Query: 74 GTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGK-----V 126
L PWF ++R+ AER L P G FL+RES + G ++L V + V
Sbjct: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178
Query: 127 EHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYR 185
+HY+I I + F L +LV HYT+ +DGLCTRL +P T Q ++
Sbjct: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ---TQKPQKPWWE 235
Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMTQL 243
W + + LKL++ +G G+FG+V +G Y G+ KVAVK +K + + AFLAEA++M QL
Sbjct: 236 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL 295
Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303
+H LV+L V+ +E +YI+TEYM GSLVD+L++ L + LL + + E M
Sbjct: 296 QHQRLVRLYAVVTQEP--IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359
++E N++HRDL A N+LVS+ K++DFGL + + T K P+KWTAPEA+
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
F+ KSDVWSFGILL EI + GR+PYP + +V+ +E+GY+M PD CP +Y++M
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
Query: 420 KNCWHLDAAMRPSFLQLREQLEHIKT 445
+ CW RP+F LR LE T
Sbjct: 474 RLCWKERPEDRPTFDYLRSVLEDFFT 499
>gi|112789546 lymphocyte-specific protein tyrosine kinase precursor
[Homo sapiens]
Length = 509
Score = 297 bits (761), Expect = 1e-80
Identities = 177/446 (39%), Positives = 260/446 (58%), Gaps = 28/446 (6%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73
IA +++ + + DL F KG+ L I+ + + W+KA++ G+EG IP N+V K
Sbjct: 67 IALHSYEPSHDGDLGFEKGEQLRILEQSGE--WWKAQSLTTGQEGFIPFNFVAK------ 118
Query: 74 GTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSCDGK-----V 126
L PWF ++R+ AER L P G FL+RES + G ++L V + V
Sbjct: 119 ANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVV 178
Query: 127 EHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYR 185
+HY+I I + F L +LV HYT+ +DGLCTRL +P T Q ++
Sbjct: 179 KHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQ---TQKPQKPWWE 235
Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMTQL 243
W + + LKL++ +G G+FG+V +G Y G+ KVAVK +K + + AFLAEA++M QL
Sbjct: 236 DEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQL 295
Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303
+H LV+L V+ +E +YI+TEYM GSLVD+L++ L + LL + + E M
Sbjct: 296 QHQRLVRLYAVVTQEP--IYIITEYMENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMA 353
Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359
++E N++HRDL A N+LVS+ K++DFGL + + T K P+KWTAPEA+
Sbjct: 354 FIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAIN 413
Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
F+ KSDVWSFGILL EI + GR+PYP + +V+ +E+GY+M PD CP +Y++M
Sbjct: 414 YGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLERGYRMVRPDNCPEELYQLM 473
Query: 420 KNCWHLDAAMRPSFLQLREQLEHIKT 445
+ CW RP+F LR LE T
Sbjct: 474 RLCWKERPEDRPTFDYLRSVLEDFFT 499
>gi|38202217 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 294 bits (753), Expect = 1e-79
Identities = 179/444 (40%), Positives = 250/444 (56%), Gaps = 24/444 (5%)
Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71
T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + +
Sbjct: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146
Query: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS----CDG- 124
+A W+ GKITR ++ERLL E G FLVRES G Y L VS G
Sbjct: 147 QAEE------WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 200
Query: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEF 183
V+HY+I + I F +L QLV +Y+ ADGLC RL V +
Sbjct: 201 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 258
Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMT 241
+ W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM
Sbjct: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301
+LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + +
Sbjct: 319 KLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357
M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 417
+F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP ++++
Sbjct: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496
Query: 418 VMKNCWHLDAAMRPSFLQLREQLE 441
+M CW + RP+F L+ LE
Sbjct: 497 LMCQCWRKEPEERPTFEYLQAFLE 520
>gi|4885609 proto-oncogene tyrosine-protein kinase SRC [Homo
sapiens]
Length = 536
Score = 294 bits (753), Expect = 1e-79
Identities = 179/444 (40%), Positives = 250/444 (56%), Gaps = 24/444 (5%)
Query: 12 TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGV 71
T +A Y++ E DL F KG+ L IV T+ W G+ G IP+NYV + +
Sbjct: 87 TTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSI 146
Query: 72 KAGTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVS----CDG- 124
+A W+ GKITR ++ERLL E G FLVRES G Y L VS G
Sbjct: 147 QAEE------WYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGL 200
Query: 125 KVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEF 183
V+HY+I + I F +L QLV +Y+ ADGLC RL V +
Sbjct: 201 NVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPTSKPQTQGL 258
Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMT 241
+ W + + L+L +G+G FG+V +G + G +VA+K +K + +AFL EA VM
Sbjct: 259 AKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMK 318
Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301
+LRH LVQL V+ EE +YIVTEYM+KGSL+D+L+ L L+ + +
Sbjct: 319 KLRHEKLVQLYAVVSEEP--IYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASG 376
Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357
M Y+E N+VHRDL A N+LV E+ V KV+DFGL + + T K P+KWTAPEA
Sbjct: 377 MAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEA 436
Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 417
+F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP ++++
Sbjct: 437 ALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHD 496
Query: 418 VMKNCWHLDAAMRPSFLQLREQLE 441
+M CW + RP+F L+ LE
Sbjct: 497 LMCQCWRKEPEERPTFEYLQAFLE 520
>gi|33469982 B lymphoid tyrosine kinase [Homo sapiens]
Length = 505
Score = 293 bits (749), Expect = 3e-79
Identities = 174/445 (39%), Positives = 260/445 (58%), Gaps = 27/445 (6%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKV-GREGIIPANYVQKREGVKA 73
+A Y++ ++DL KG+ L ++ T D W+ A++ V GREG +P+N+V + E
Sbjct: 64 VALYDYTAMNDRDLQMLKGEKLQVLKGTGD--WWLARSLVTGREGYVPSNFVARVES--- 118
Query: 74 GTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCV---SCDGK-VE 127
L + WF R++AER L P + G FL+RES G ++L V + G+ ++
Sbjct: 119 ---LEMERWFFRSQGRKEAERQLLAPINKAGSFLIRESETNKGAFSLSVKDVTTQGELIK 175
Query: 128 HYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186
HY+I I + F +L LV+HY+ DGLC RL P V A Q+ + +
Sbjct: 176 HYKIRCLDEGGYYISPRITFPSLQALVQHYSKKGDGLCQRLTLPCVRP---APQNPWAQD 232
Query: 187 GWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATA-QAFLAEASVMTQLR 244
W + + L+L++ +G G+FG+V +G Y+ N KVA+K +K + +AFL EA+VM L+
Sbjct: 233 EWEIPRQSLRLVRKLGSGQFGEVWMGYYKNNMKVAIKTLKEGTMSPEAFLGEANVMKALQ 292
Query: 245 HSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEY 304
H LV+L V+ +E +YIVTEYMA+G L+D+L++ S L L+ S + E M Y
Sbjct: 293 HERLVRLYAVVTKEP--IYIVTEYMARGCLLDFLKTDEGSRLSLPRLIDMSAQIAEGMAY 350
Query: 305 LEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASS---TQDTGKLPVKWTAPEALREK 361
+E N +HRDL A N+LVSE K++DFGL + S Q+ K P+KWTAPEA+
Sbjct: 351 IERMNSIHRDLRAANILVSEALCCKIADFGLARIIDSEYTAQEGAKFPIKWTAPEAIHFG 410
Query: 362 KFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE-VMK 420
F+ K+DVWSFG+LL E+ ++GRVPYP + +V+ +E+GY+M PD CPP +Y V+
Sbjct: 411 VFTIKADVWSFGVLLMEVVTYGRVPYPGMSNPEVIRNLERGYRMPRPDTCPPELYRGVIA 470
Query: 421 NCWHLDAAMRPSFLQLREQLEHIKT 445
CW RP+F L+ LE T
Sbjct: 471 ECWRSRPEERPTFEFLQSVLEDFYT 495
>gi|4885661 viral oncogene yes-1 homolog 1 [Homo sapiens]
Length = 543
Score = 293 bits (749), Expect = 3e-79
Identities = 174/460 (37%), Positives = 259/460 (56%), Gaps = 31/460 (6%)
Query: 2 SAIQAAWPSG-----TECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR 56
S + +++P+G T +A Y++ +DL F KG+ I+ T+ W G+
Sbjct: 79 SVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGK 138
Query: 57 EGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPG 114
G IP+NYV + ++A W+ GK+ R+ AERLL P + G+FLVRES G
Sbjct: 139 NGYIPSNYVAPADSIQAEE------WYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKG 192
Query: 115 DYTLCVSC-----DGKVEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLI 168
Y+L + V+HY+I I F+ L +LV+HYT ADGLC +L
Sbjct: 193 AYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLT 252
Query: 169 KPKVMEGTVAAQDE-FYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK- 225
+ TV Q + + W + + L+L +G+G FG+V +G + G KVA+K +K
Sbjct: 253 ---TVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKP 309
Query: 226 NDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSV 285
+AFL EA +M +LRH LV L V+ EE +YIVTE+M+KGSL+D+L+
Sbjct: 310 GTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEP--IYIVTEFMSKGSLLDFLKEGDGKY 367
Query: 286 LGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDT 345
L L+ + + + M Y+E N++HRDL A N+LV E+ V K++DFGL + + T
Sbjct: 368 LKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYT 427
Query: 346 G----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEK 401
K P+KWTAPEA +F+ KSDVWSFGIL E+ + GRVPYP + ++V+ +VE+
Sbjct: 428 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVER 487
Query: 402 GYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLE 441
GY+M P GCP +++E+M CW D RP+F ++ LE
Sbjct: 488 GYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLE 527
>gi|162287326 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform B [Homo sapiens]
Length = 491
Score = 291 bits (744), Expect = 1e-78
Identities = 174/451 (38%), Positives = 254/451 (56%), Gaps = 29/451 (6%)
Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKRE 69
G +A Y + G DL F KG+ + ++ + W+KAK+ + + EG IP+NYV K
Sbjct: 44 GDIVVALYPYDGIHPDDLSFKKGEKMKVLE--EHGEWWKAKSLLTKKEGFIPSNYVAKLN 101
Query: 70 GVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVE 127
L WF ITR+ AER L P G FL+RES G ++L V D
Sbjct: 102 ------TLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVR-DFDPV 154
Query: 128 HYRIMYHASKLSIDEEVY-------FENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ 180
H ++ H S+D Y F + +++HY ADGLC RL K + + Q
Sbjct: 155 HGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACI---SPKPQ 211
Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEAS 238
+ + W + + +KL++ +G G+FG+V +G Y + KVAVK +K + QAFL EA+
Sbjct: 212 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEAN 271
Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298
+M L+H LV+L V+ E+ +YI+TEYMAKGSL+D+L+S + L+ FS +
Sbjct: 272 LMKTLQHDKLVRLYAVVTREEP-IYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 330
Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTA 354
E M Y+E N++HRDL A NVLVSE + K++DFGL + + T K P+KWTA
Sbjct: 331 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 390
Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414
PEA+ F+ KSDVWSFGILL+EI ++G++PYP DV+ + +GY+M + CP
Sbjct: 391 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 450
Query: 415 VYEVMKNCWHLDAAMRPSFLQLREQLEHIKT 445
+Y++MK CW A RP+F L+ L+ T
Sbjct: 451 LYDIMKMCWKEKAEERPTFDYLQSVLDDFYT 481
>gi|4505055 Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
isoform A [Homo sapiens]
Length = 512
Score = 291 bits (744), Expect = 1e-78
Identities = 174/451 (38%), Positives = 254/451 (56%), Gaps = 29/451 (6%)
Query: 11 GTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKRE 69
G +A Y + G DL F KG+ + ++ + W+KAK+ + + EG IP+NYV K
Sbjct: 65 GDIVVALYPYDGIHPDDLSFKKGEKMKVLE--EHGEWWKAKSLLTKKEGFIPSNYVAKLN 122
Query: 70 GVKAGTKLSLMPWFHGKITREQAERLLYPP--ETGLFLVRESTNYPGDYTLCVSCDGKVE 127
L WF ITR+ AER L P G FL+RES G ++L V D
Sbjct: 123 ------TLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVR-DFDPV 175
Query: 128 HYRIMYHASKLSIDEEVY-------FENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQ 180
H ++ H S+D Y F + +++HY ADGLC RL K + + Q
Sbjct: 176 HGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACI---SPKPQ 232
Query: 181 DEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEAS 238
+ + W + + +KL++ +G G+FG+V +G Y + KVAVK +K + QAFL EA+
Sbjct: 233 KPWDKDAWEIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEAN 292
Query: 239 VMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDV 298
+M L+H LV+L V+ E+ +YI+TEYMAKGSL+D+L+S + L+ FS +
Sbjct: 293 LMKTLQHDKLVRLYAVVTREEP-IYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQI 351
Query: 299 CEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTA 354
E M Y+E N++HRDL A NVLVSE + K++DFGL + + T K P+KWTA
Sbjct: 352 AEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTA 411
Query: 355 PEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPA 414
PEA+ F+ KSDVWSFGILL+EI ++G++PYP DV+ + +GY+M + CP
Sbjct: 412 PEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDE 471
Query: 415 VYEVMKNCWHLDAAMRPSFLQLREQLEHIKT 445
+Y++MK CW A RP+F L+ L+ T
Sbjct: 472 LYDIMKMCWKEKAEERPTFDYLQSVLDDFYT 502
>gi|4503823 protein-tyrosine kinase fyn isoform a [Homo sapiens]
Length = 537
Score = 286 bits (731), Expect = 3e-77
Identities = 171/449 (38%), Positives = 258/449 (57%), Gaps = 37/449 (8%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73
+A Y++ E DL F KG+ I+ + + +W++A++ G G IP+NYV + ++A
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSIQA 146
Query: 74 GTKLSLMPWFHGKITREQAERLL--YPPETGLFLVRESTNYPGDYTLCVSC--DGKVEHY 129
W+ GK+ R+ AER L + G FL+RES G Y+L + D K +H
Sbjct: 147 EE------WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV 200
Query: 130 RIMYHASKLS-----IDEEVYFENLMQLVEHYTSDADGLCTRLI------KPKVMEGTVA 178
+ Y KL I FE L QLV+HY+ A GLC RL+ P++ + +V
Sbjct: 201 K-HYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVK 259
Query: 179 AQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAE 236
+D W + + L+L++ +G G+FG+V +G + GN KVA+K +K + ++FL E
Sbjct: 260 TKDV-----WEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEE 314
Query: 237 ASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSL 296
A +M +L+H LVQL V+ EE +YIVTEYM KGSL+D+L+ L L+ +
Sbjct: 315 AQIMKKLKHDKLVQLYAVVSEEP--IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAA 372
Query: 297 DVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKW 352
V M Y+E N++HRDL + N+LV + K++DFGL + + T K P+KW
Sbjct: 373 QVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKW 432
Query: 353 TAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCP 412
TAPEA +F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP
Sbjct: 433 TAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP 492
Query: 413 PAVYEVMKNCWHLDAAMRPSFLQLREQLE 441
+++E+M +CW D RP+F L+ LE
Sbjct: 493 ISLHELMIHCWKKDPEERPTFEYLQSFLE 521
>gi|112382244 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 285 bits (730), Expect = 5e-77
Identities = 174/442 (39%), Positives = 243/442 (54%), Gaps = 26/442 (5%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
IA Y++ E DL F KG+ I+ T+ W G+ G IP+NYV + ++A
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 75 TKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCV-----SCDGKVE 127
W+ GKI R+ AER L P G FL+RES G Y+L + + V+
Sbjct: 143 E------WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVK 196
Query: 128 HYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP-KVMEGTVAAQDEFYR 185
HY+I I V F ++ +LV+HY DGLC LI P +M+ +
Sbjct: 197 HYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLG---LAK 253
Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQL 243
W ++ + L + +G G FGDV LG + G+ KVAVK +K + +AFL EA VM L
Sbjct: 254 DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLL 313
Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303
RH LVQL V+ EE +YIVTE+M GSL+D+L++ L L+ + V E M
Sbjct: 314 RHDKLVQLYAVVSEEP--IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371
Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAPEALR 359
Y+E N++HRDL A N+LV E K++DFGL + + K P+KWTAPEA
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
+F+ KSDVWSFGILL E+ + GR+PYP + ++V+ +VE+GY M P GCP ++YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491
Query: 420 KNCWHLDAAMRPSFLQLREQLE 441
+ W LD RP+F L+ LE
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLE 513
>gi|112382241 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 285 bits (730), Expect = 5e-77
Identities = 174/442 (39%), Positives = 243/442 (54%), Gaps = 26/442 (5%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
IA Y++ E DL F KG+ I+ T+ W G+ G IP+NYV + ++A
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 75 TKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCV-----SCDGKVE 127
W+ GKI R+ AER L P G FL+RES G Y+L + + V+
Sbjct: 143 E------WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVK 196
Query: 128 HYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP-KVMEGTVAAQDEFYR 185
HY+I I V F ++ +LV+HY DGLC LI P +M+ +
Sbjct: 197 HYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLG---LAK 253
Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQL 243
W ++ + L + +G G FGDV LG + G+ KVAVK +K + +AFL EA VM L
Sbjct: 254 DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLL 313
Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303
RH LVQL V+ EE +YIVTE+M GSL+D+L++ L L+ + V E M
Sbjct: 314 RHDKLVQLYAVVSEEP--IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371
Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAPEALR 359
Y+E N++HRDL A N+LV E K++DFGL + + K P+KWTAPEA
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
+F+ KSDVWSFGILL E+ + GR+PYP + ++V+ +VE+GY M P GCP ++YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491
Query: 420 KNCWHLDAAMRPSFLQLREQLE 441
+ W LD RP+F L+ LE
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLE 513
>gi|4885235 proto-oncogene tyrosine-protein kinase FGR [Homo
sapiens]
Length = 529
Score = 285 bits (730), Expect = 5e-77
Identities = 174/442 (39%), Positives = 243/442 (54%), Gaps = 26/442 (5%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
IA Y++ E DL F KG+ I+ T+ W G+ G IP+NYV + ++A
Sbjct: 83 IALYDYEARTEDDLTFTKGEKFHILNNTEGDWWEARSLSSGKTGCIPSNYVAPVDSIQAE 142
Query: 75 TKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCV-----SCDGKVE 127
W+ GKI R+ AER L P G FL+RES G Y+L + + V+
Sbjct: 143 E------WYFGKIGRKDAERQLLSPGNPQGAFLIRESETTKGAYSLSIRDWDQTRGDHVK 196
Query: 128 HYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKP-KVMEGTVAAQDEFYR 185
HY+I I V F ++ +LV+HY DGLC LI P +M+ +
Sbjct: 197 HYKIRKLDMGGYYITTRVQFNSVQELVQHYMEVNDGLCNLLIAPCTIMKPQTLG---LAK 253
Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQL 243
W ++ + L + +G G FGDV LG + G+ KVAVK +K + +AFL EA VM L
Sbjct: 254 DAWEISRSSITLERRLGTGCFGDVWLGTWNGSTKVAVKTLKPGTMSPKAFLEEAQVMKLL 313
Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303
RH LVQL V+ EE +YIVTE+M GSL+D+L++ L L+ + V E M
Sbjct: 314 RHDKLVQLYAVVSEEP--IYIVTEFMCHGSLLDFLKNPEGQDLRLPQLVDMAAQVAEGMA 371
Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQ----DTGKLPVKWTAPEALR 359
Y+E N++HRDL A N+LV E K++DFGL + + K P+KWTAPEA
Sbjct: 372 YMERMNYIHRDLRAANILVGERLACKIADFGLARLIKDDEYNPCQGSKFPIKWTAPEAAL 431
Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
+F+ KSDVWSFGILL E+ + GR+PYP + ++V+ +VE+GY M P GCP ++YE M
Sbjct: 432 FGRFTIKSDVWSFGILLTELITKGRIPYPGMNKREVLEQVEQGYHMPCPPGCPASLYEAM 491
Query: 420 KNCWHLDAAMRPSFLQLREQLE 441
+ W LD RP+F L+ LE
Sbjct: 492 EQTWRLDPEERPTFEYLQSFLE 513
>gi|30795229 hemopoietic cell kinase isoform p61HCK [Homo sapiens]
Length = 526
Score = 285 bits (729), Expect = 6e-77
Identities = 169/446 (37%), Positives = 248/446 (55%), Gaps = 28/446 (6%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGR-EGIIPANYVQKREGVKA 73
+A Y++ +DL F KGD + V + + W+KA++ R EG IP+NYV + +
Sbjct: 84 VALYDYEAIHHEDLSFQKGDQM--VVLEESGEWWKARSLATRKEGYIPSNYVARVDS--- 138
Query: 74 GTKLSLMPWFHGKITREQAERLLYPPET--GLFLVRESTNYPGDYTLCVSC-----DGKV 126
L WF I+R+ AER L P G F++R+S G Y+L V V
Sbjct: 139 ---LETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSYSLSVRDYDPRQGDTV 195
Query: 127 EHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYR 185
+HY+I I F L +LV+HY DGLC +L P + Q + +
Sbjct: 196 KHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVPCMSS---KPQKPWEK 252
Query: 186 SGWALNMKELKLLQTIGKGEFGDVMLGDY-RGNKVAVKCIK-NDATAQAFLAEASVMTQL 243
W + + LKL + +G G+FG+V + Y + KVAVK +K + +AFLAEA+VM L
Sbjct: 253 DAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANVMKTL 312
Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303
+H LV+L V+ +E +YI+TE+MAKGSL+D+L+S S L+ FS + E M
Sbjct: 313 QHDKLVKLHAVVTKEP--IYIITEFMAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMA 370
Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359
++E N++HRDL A N+LVS V K++DFGL + + T K P+KWTAPEA+
Sbjct: 371 FIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAIN 430
Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
F+ KSDVWSFGILL EI ++GR+PYP + +V+ +E+GY+M P+ CP +Y +M
Sbjct: 431 FGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIM 490
Query: 420 KNCWHLDAAMRPSFLQLREQLEHIKT 445
CW RP+F ++ L+ T
Sbjct: 491 MRCWKNRPEERPTFEYIQSVLDDFYT 516
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 285 bits (729), Expect = 6e-77
Identities = 161/415 (38%), Positives = 250/415 (60%), Gaps = 22/415 (5%)
Query: 44 DPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLL-YPPETG 102
+P+W+KA++++G EG+IP+NYV + + T L + W+H ITR QAE LL + G
Sbjct: 116 NPHWWKARDRLGNEGLIPSNYVTENKI----TNLEIYEWYHRNITRNQAEHLLRQESKEG 171
Query: 103 LFLVRESTNYPGDYTLCV------SCDGKVEHYRIMYHAS-KLSIDEEVYFENLMQLVEH 155
F+VR+S + G YT+ V S + ++HY+I + S + + E F+++ +L+ +
Sbjct: 172 AFIVRDSRHL-GSYTISVFMGARRSTEAAIKHYQIKKNDSGQWYVAERHAFQSIPELIWY 230
Query: 156 YTSDADGLCTRLIKPKVMEGT-VAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDY 214
+ +A GL TRL P + G+ + A F W ++ EL ++ IG G+FG V LG++
Sbjct: 231 HQHNAAGLMTRLRYPVGLMGSCLPATAGFSYEKWEIDPSELAFIKEIGSGQFGVVHLGEW 290
Query: 215 RGN-KVAVKCIKNDATAQA-FLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKG 272
R + +VA+K I + ++ F+ EA VM +L HS LVQL GV ++ K LYIVTE+M G
Sbjct: 291 RSHIQVAIKAINEGSMSEEDFIEEAKVMMKLSHSKLVQLYGVCIQRKP-LYIVTEFMENG 349
Query: 273 SLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSD 332
L++YLR + L + LL D+CE MEYLE N ++HRDLAARN LVS + K+SD
Sbjct: 350 CLLNYLREN-KGKLRKEMLLSVCQDICEGMEYLERNGYIHRDLAARNCLVSSTCIVKISD 408
Query: 333 FGLTKEASSTQDTG----KLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYP 388
FG+T+ + K P+KW+ PE K+S+KSDVWSFG+L+WE+++ G++P+
Sbjct: 409 FGMTRYVLDDEYVSSFGAKFPIKWSPPEVFLFNKYSSKSDVWSFGVLMWEVFTEGKMPFE 468
Query: 389 RIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443
VV + +G+++ P P ++YEVM +CWH RP+F +L + I
Sbjct: 469 NKSNLQVVEAISEGFRLYRPHLAPMSIYEVMYSCWHEKPEGRPTFAELLRAVTEI 523
>gi|23510362 protein-tyrosine kinase fyn isoform b [Homo sapiens]
Length = 534
Score = 278 bits (711), Expect = 7e-75
Identities = 168/443 (37%), Positives = 248/443 (55%), Gaps = 28/443 (6%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKN-KVGREGIIPANYVQKREGVKA 73
+A Y++ E DL F KG+ I+ + + +W++A++ G G IP+NYV + ++A
Sbjct: 88 VALYDYEARTEDDLSFHKGEKFQILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSIQA 146
Query: 74 GTKLSLMPWFHGKITREQAERLL--YPPETGLFLVRESTNYPGDYTLCVSC--DGKVEHY 129
W+ GK+ R+ AER L + G FL+RES G Y+L + D K +H
Sbjct: 147 EE------WYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHV 200
Query: 130 RIMYHASKLS-----IDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFY 184
+ Y KL I FE L QLV+HY+ ADGLC L +
Sbjct: 201 K-HYKIRKLDNGGYYITTRAQFETLQQLVQHYSEKADGLCFNLTV--IASSCTPQTSGLA 257
Query: 185 RSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIK-NDATAQAFLAEASVMTQ 242
+ W + + L L + +G+G F +V LG + GN KVA+K +K + ++FL EA +M +
Sbjct: 258 KDAWEVARRSLCLEKKLGQGCFAEVWLGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKK 317
Query: 243 LRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAM 302
L+H LVQL V+ EE +YIVTEYM KGSL+D+L+ L L+ + V M
Sbjct: 318 LKHDKLVQLYAVVSEEP--IYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGM 375
Query: 303 EYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEAL 358
Y+E N++HRDL + N+LV + K++DFGL + + T K P+KWTAPEA
Sbjct: 376 AYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAA 435
Query: 359 REKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEV 418
+F+ KSDVWSFGILL E+ + GRVPYP + ++V+ +VE+GY+M P CP +++E+
Sbjct: 436 LYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHEL 495
Query: 419 MKNCWHLDAAMRPSFLQLREQLE 441
M +CW D RP+F L+ LE
Sbjct: 496 MIHCWKKDPEERPTFEYLQSFLE 518
>gi|4503787 fyn-related kinase [Homo sapiens]
Length = 505
Score = 276 bits (706), Expect = 3e-74
Identities = 168/448 (37%), Positives = 243/448 (54%), Gaps = 28/448 (6%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREG-------IIPANYVQK 67
+A +++ +DL F GD L ++ + W+ + R+G IP+NYV +
Sbjct: 48 VALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAE 107
Query: 68 REGVKAGTKLSLMPWFHGKITREQAER-LLYPP-ETGLFLVRESTNYPGDYTLCVSCDGK 125
++A PWF G I R AE+ LLY +TG FL+RES + G+++L V
Sbjct: 108 DRSLQAE------PWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAV 161
Query: 126 VEHYRIM-YHASKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFY 184
V+HYRI + F L + V HYT +DGLC +L KP + A D Y
Sbjct: 162 VKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSY 221
Query: 185 RS--GWALNMKELKLLQTIGKGEFGDVMLGDYRGNK-VAVKCIK-NDATAQAFLAEASVM 240
++ W ++ ++LL+ +G G+FG+V G + VAVK +K FL EA +M
Sbjct: 222 KTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIM 281
Query: 241 TQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCE 300
LRH L+QL V E +YI+TE M GSL +YL++ S + + + V
Sbjct: 282 KNLRHPKLIQLYAVCTLEDP-IYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVAS 340
Query: 301 AMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-------EASSTQDTGKLPVKWT 353
M YLE N++HRDLAARNVLV E N+ KV+DFGL + + ++ KLPVKWT
Sbjct: 341 GMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWT 400
Query: 354 APEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP 413
APEA+R KFS KSDVWSFGILL+EI ++G++PY + V+ + + Y++ P CP
Sbjct: 401 APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQ 460
Query: 414 AVYEVMKNCWHLDAAMRPSFLQLREQLE 441
Y +M CW+ + RP+F LR +LE
Sbjct: 461 QFYNIMLECWNAEPKERPTFETLRWKLE 488
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 274 bits (701), Expect = 1e-73
Identities = 171/446 (38%), Positives = 245/446 (54%), Gaps = 25/446 (5%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y+F DL +G I+ D +W++A++K G EG IP+NYV K
Sbjct: 185 VAMYDFQAAEGHDLRLERGQEYLILE-KNDVHWWRARDKYGNEGYIPSNYVTG----KKS 239
Query: 75 TKLSLMPWFHGKITREQAERLLYPPET-GLFLVRESTNYPGDYTLCVSC------DGKVE 127
L W+ + R +AE+LL + G F+VR+S+ PG YT+ +
Sbjct: 240 NNLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQ-PGLYTVSLYTKFGGEGSSGFR 298
Query: 128 HYRIMYHAS---KLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDE-F 183
HY I + K + E+ F ++ +++E++ +A GL TRL P ++G A F
Sbjct: 299 HYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGF 358
Query: 184 YRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQA-FLAEASVMT 241
W +N EL ++ +G G FG V LG +R KVA+K I+ A + F+ EA VM
Sbjct: 359 SYEKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMM 418
Query: 242 QLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEA 301
+L H LVQL GV ++K +YIVTE+M +G L+++LR R + D LL DVCE
Sbjct: 419 KLTHPKLVQLYGVCTQQKP-IYIVTEFMERGCLLNFLRQR-QGHFSRDVLLSMCQDVCEG 476
Query: 302 MEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEA 357
MEYLE N+F+HRDLAARN LVSE V KVSDFG+ + Q T K PVKW PE
Sbjct: 477 MEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEV 536
Query: 358 LREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYE 417
+FS+KSDVWSFG+L+WE+++ GR+P+ + +VV V +G+++ P VYE
Sbjct: 537 FNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYE 596
Query: 418 VMKNCWHLDAAMRPSFLQLREQLEHI 443
VM CW RPSF L ++ +
Sbjct: 597 VMLRCWQEKPEGRPSFEDLLRTIDEL 622
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 271 bits (692), Expect = 1e-72
Identities = 166/448 (37%), Positives = 248/448 (55%), Gaps = 24/448 (5%)
Query: 15 IAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAG 74
+A Y++ DL KGD I+ + P W++A++K G+EG IP+NYV + E
Sbjct: 220 VALYDYMPMNANDLQLRKGDEYFILEESNLP-WWRARDKNGQEGYIPSNYVTEAED---- 274
Query: 75 TKLSLMPWFHGKITREQAERLLYPP-ETGLFLVRESTNYPGDYTLCVSC------DGKVE 127
+ + W+ +TR QAE+LL + G F+VR+S+ G YT+ V G +
Sbjct: 275 -SIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSK-AGKYTVSVFAKSTGDPQGVIR 332
Query: 128 HYRIMYHA-SKLSIDEEVYFENLMQLVEHYTSDADGLCTRLIKPKVMEGTVAAQDEFYRS 186
HY + S+ + E+ F + +L+ ++ ++ GL +RL P + A
Sbjct: 333 HYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSQQNKNAPSTAGLGY 392
Query: 187 G-WALNMKELKLLQTIGKGEFGDVMLGDYRGN-KVAVKCIKNDATAQ-AFLAEASVMTQL 243
G W ++ K+L L+ +G G+FG V G +RG VA+K IK + ++ F+ EA VM L
Sbjct: 393 GSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNL 452
Query: 244 RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAME 303
H LVQL GV +++ ++I+TEYMA G L++YLR R LL+ DVCEAME
Sbjct: 453 SHEKLVQLYGVCTKQRP-IFIITEYMANGCLLNYLREM-RHRFQTQQLLEMCKDVCEAME 510
Query: 304 YLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTG----KLPVKWTAPEALR 359
YLE F+HRDLAARN LV++ V KVSDFGL++ + T K PV+W+ PE L
Sbjct: 511 YLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLM 570
Query: 360 EKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVM 419
KFS+KSD+W+FG+L+WEIYS G++PY R + + +G ++ P VY +M
Sbjct: 571 YSKFSSKSDIWAFGVLMWEIYSLGKMPYERFTNSETAEHIAQGLRLYRPHLASEKVYTIM 630
Query: 420 KNCWHLDAAMRPSFLQLREQLEHIKTHE 447
+CWH A RP+F L + + E
Sbjct: 631 YSCWHEKADERPTFKILLSNILDVMDEE 658
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.413
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,196,612
Number of Sequences: 37866
Number of extensions: 757163
Number of successful extensions: 4226
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 736
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 1684
Number of HSP's gapped (non-prelim): 1210
length of query: 450
length of database: 18,247,518
effective HSP length: 106
effective length of query: 344
effective length of database: 14,233,722
effective search space: 4896400368
effective search space used: 4896400368
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.